                         SEQUENCE LISTING

<110>  MARS, INCORPORATED
 
<120>  COMPOUNDS THAT MODULATE CALCIUM-SENSING RECEPTOR ACTIVITY FOR 
       MODULATING KOKUMI TASTE AND PET FOOD PRODUCTS CONTAINING THE SAME

<130>  069269.0214

<150>  US 62/322,641
<151>  2016-04-14

<160>  2     

<170>  PatentIn version 3.5

<210>  1
<211>  1081
<212>  PRT
<213>  Felis catus

<400>  1

Met Ala Phe Tyr Ser Cys Cys Leu Ile Leu Leu Ala Ile Thr Trp Cys 
1               5                   10                  15      


Thr Ser Ala Tyr Gly Pro Asp Gln Arg Ala Gln Lys Lys Gly Asp Ile 
            20                  25                  30          


Ile Leu Gly Gly Leu Phe Pro Ile His Phe Gly Val Ala Ala Lys Asp 
        35                  40                  45              


Gln Asp Leu Lys Ser Arg Pro Glu Ser Val Glu Cys Ile Arg Tyr Asn 
    50                  55                  60                  


Phe Arg Gly Phe Arg Trp Leu Gln Ala Met Ile Phe Ala Ile Glu Glu 
65                  70                  75                  80  


Ile Asn Ser Ser Pro Val Leu Leu Pro Asn Met Thr Leu Gly Tyr Arg 
                85                  90                  95      


Ile Phe Asp Thr Cys Asn Thr Val Ser Lys Ala Leu Glu Ala Thr Leu 
            100                 105                 110         


Ser Phe Val Ala Gln Asn Lys Ile Asp Ser Leu Asn Leu Asp Glu Phe 
        115                 120                 125             


Cys Asn Cys Ser Glu His Ile Pro Ser Thr Ile Ala Val Val Gly Ala 
    130                 135                 140                 


Thr Gly Ser Gly Ile Ser Thr Ala Val Ala Asn Leu Leu Gly Leu Phe 
145                 150                 155                 160 


Tyr Ile Pro Gln Val Ser Tyr Ala Ser Ser Ser Arg Leu Leu Ser Asn 
                165                 170                 175     


Lys Asn Gln Phe Lys Ser Phe Leu Arg Thr Ile Pro Asn Asp Glu His 
            180                 185                 190         


Gln Ala Thr Ala Met Ala Asp Ile Ile Glu Tyr Phe Arg Trp Asn Trp 
        195                 200                 205             


Val Gly Thr Ile Ala Ala Asp Asp Asp Tyr Gly Arg Pro Gly Ile Glu 
    210                 215                 220                 


Lys Phe Arg Glu Glu Ala Glu Glu Arg Asp Ile Cys Ile Asp Phe Ser 
225                 230                 235                 240 


Glu Leu Ile Ser Gln Tyr Ser Asp Glu Glu Glu Ile Gln Gln Val Val 
                245                 250                 255     


Glu Val Ile Gln Asn Ser Thr Ala Lys Val Ile Val Val Phe Ser Ser 
            260                 265                 270         


Gly Pro Asp Leu Glu Pro Leu Ile Lys Glu Ile Val Arg Arg Asn Ile 
        275                 280                 285             


Thr Gly Arg Ile Trp Leu Ala Ser Glu Ala Trp Ala Ser Ser Ser Leu 
    290                 295                 300                 


Ile Ala Met Pro Glu Tyr Phe His Val Val Gly Gly Thr Ile Gly Phe 
305                 310                 315                 320 


Ala Leu Lys Ala Gly Gln Ile Pro Gly Phe Arg Glu Phe Leu Gln Lys 
                325                 330                 335     


Val His Pro Arg Lys Ser Val His Asn Gly Phe Ala Lys Glu Phe Trp 
            340                 345                 350         


Glu Glu Thr Phe Asn Cys His Leu Gln Glu Gly Ala Lys Gly Pro Leu 
        355                 360                 365             


Ala Leu Asp Thr Phe Leu Arg Gly His Glu Glu Gly Gly Gly Arg Ile 
    370                 375                 380                 


Ser Asn Ser Ser Thr Ala Leu Arg Pro Leu Cys Thr Gly Asp Glu Asn 
385                 390                 395                 400 


Ile Ser Ser Val Glu Thr Pro Tyr Met Asp Tyr Thr His Leu Arg Ile 
                405                 410                 415     


Ser Tyr Asn Val Tyr Leu Ala Val Tyr Ser Ile Ala His Ala Leu Gln 
            420                 425                 430         


Asp Ile Tyr Thr Cys Leu Pro Gly Arg Gly Leu Phe Thr Asn Gly Ser 
        435                 440                 445             


Cys Ala Asp Ile Lys Lys Val Glu Ala Trp Gln Val Leu Lys His Leu 
    450                 455                 460                 


Arg His Leu Asn Phe Thr Asn Asn Met Gly Glu Gln Val Thr Phe Asp 
465                 470                 475                 480 


Glu Cys Gly Asp Leu Val Gly Asn Tyr Ser Ile Ile Asn Trp His Leu 
                485                 490                 495     


Ser Pro Glu Asp Gly Ser Ile Val Phe Lys Glu Val Gly Tyr Tyr Asn 
            500                 505                 510         


Val Tyr Ala Lys Lys Gly Glu Arg Leu Phe Ile Asn Glu Glu Lys Ile 
        515                 520                 525             


Leu Trp Ser Gly Phe Ser Arg Glu Val Pro Phe Ser Asn Cys Ser Arg 
    530                 535                 540                 


Asp Cys Leu Ala Gly Thr Arg Lys Gly Ile Ile Glu Gly Glu Pro Thr 
545                 550                 555                 560 


Cys Cys Phe Glu Cys Val Glu Cys Pro Asp Gly Glu Tyr Ser Asp Glu 
                565                 570                 575     


Thr Asp Ala Ser Ala Cys Asp Lys Cys Pro Asp Asp Phe Trp Ser Asn 
            580                 585                 590         


Glu Asn His Thr Ser Cys Ile Ala Lys Glu Ile Glu Phe Leu Ser Trp 
        595                 600                 605             


Thr Glu Pro Phe Gly Ile Ala Leu Thr Leu Phe Ala Val Leu Gly Ile 
    610                 615                 620                 


Phe Leu Thr Ala Phe Val Leu Gly Val Phe Leu Lys Phe Arg Asn Thr 
625                 630                 635                 640 


Pro Ile Val Lys Ala Thr Asn Arg Glu Leu Ser Tyr Leu Leu Leu Phe 
                645                 650                 655     


Ser Leu Leu Cys Cys Phe Ser Ser Ser Leu Phe Phe Ile Gly Glu Pro 
            660                 665                 670         


Gln Asp Trp Thr Cys Arg Leu Arg Gln Pro Ala Phe Gly Ile Ser Phe 
        675                 680                 685             


Val Leu Cys Ile Ser Cys Ile Leu Val Lys Thr Asn Arg Val Leu Leu 
    690                 695                 700                 


Val Phe Glu Ala Lys Ile Pro Thr Ser Phe His Arg Lys Trp Trp Gly 
705                 710                 715                 720 


Leu Asn Leu Gln Phe Leu Leu Val Phe Leu Cys Thr Phe Met Gln Ile 
                725                 730                 735     


Val Ile Cys Val Ile Trp Leu Tyr Thr Ala Pro Pro Ser Ser Tyr Arg 
            740                 745                 750         


Asn His Glu Leu Glu Asp Glu Ile Ile Phe Ile Thr Cys His Glu Gly 
        755                 760                 765             


Ser Leu Met Ala Leu Gly Phe Leu Ile Gly Tyr Thr Cys Leu Leu Ala 
    770                 775                 780                 


Ala Ile Cys Phe Phe Phe Ala Phe Lys Ser Arg Lys Leu Pro Glu Asn 
785                 790                 795                 800 


Phe Asn Glu Ala Lys Phe Ile Thr Phe Ser Met Leu Ile Phe Phe Ile 
                805                 810                 815     


Val Trp Ile Ser Phe Ile Pro Ala Tyr Ala Ser Thr Tyr Gly Lys Phe 
            820                 825                 830         


Val Ser Ala Val Glu Val Ile Ala Ile Leu Ala Ala Ser Phe Gly Leu 
        835                 840                 845             


Leu Ala Cys Ile Phe Phe Asn Lys Val Tyr Ile Ile Leu Phe Lys Pro 
    850                 855                 860                 


Ser Arg Asn Thr Ile Glu Glu Val Arg Cys Ser Thr Ala Ala His Ala 
865                 870                 875                 880 


Phe Lys Val Ala Ala Arg Ala Thr Leu Arg Arg Ser Asn Val Ser Arg 
                885                 890                 895     


Lys Arg Ser Ser Ser Leu Gly Gly Ser Thr Gly Ser Thr Pro Ser Ser 
            900                 905                 910         


Ser Ile Ser Ser Lys Ser Asn Ser Glu Asp Pro Phe Pro Gln Pro Glu 
        915                 920                 925             


Arg Gln Lys Gln Gln Gln Pro Leu Ala Leu Thr Gln Gln Glu Gln Gln 
    930                 935                 940                 


Pro Gln Pro Gln Gln Pro Ser Ser Leu Gln Gln Gln Pro Gln Pro Gln 
945                 950                 955                 960 


Pro Gln Pro Arg Cys Lys Gln Lys Val Ile Phe Gly Ser Gly Thr Val 
                965                 970                 975     


Thr Phe Ser Leu Ser Phe Asp Glu Pro Gln Lys Ser Ala Met Ala His 
            980                 985                 990         


Arg Asn Ser Met His Gln Asn Ser  Leu Glu Ala Gln Lys  Ser Asn Glu 
        995                 1000                 1005             


Thr Leu  Thr Arg His Gln Ala  Leu Leu Pro Leu Gln  Cys Gly Glu 
    1010                 1015                 1020             


Thr Asp  Ser Glu Leu Ser Ala  Gln Glu Arg Gly Leu  Gln Gly Pro 
    1025                 1030                 1035             


Val Asp  Gly Asp Phe Arg Pro  Glu Met Glu Asp Pro  Glu Glu Met 
    1040                 1045                 1050             


Ser Pro  Ala Leu Val Val Ser  Ser Ser Gln Ser Phe  Val Ile Ser 
    1055                 1060                 1065             


Gly Gly  Gly Ser Thr Val Thr  Glu Asn Ile Leu His  Ser 
    1070                 1075                 1080     


<210>  2
<211>  3243
<212>  DNA
<213>  Felis catus

<400>  2
atggcatttt atagctgctg tttgatcctc ttggcaatta cctggtgcac ttctgcctat       60

gggcctgacc aacgagctca gaagaaaggg gacattatcc tcggggggct ctttcctatt      120

cattttggag tagcagccaa agatcaagat ctaaagtcaa ggccagagtc tgtggaatgt      180

atcaggtata atttccgtgg gtttcgctgg ttacaagcaa tgatatttgc catcgaggaa      240

ataaacagca gcccagtcct tcttcccaac atgacactgg gatacaggat atttgacact      300

tgcaacactg tttctaaagc cttggaggcc actctgagtt ttgtggcaca aaataaaatt      360

gattctctga acctcgacga gttctgcaac tgctcagagc atatcccctc tactatcgct      420

gtggtgggag caactggttc gggcatctcc acagcggtgg caaacctgct gggcctcttc      480

tatattcccc aggtcagcta tgcctcctcc agcagactcc tcagcaacaa aaatcagttc      540

aagtcctttc tccgtaccat ccccaatgat gaacaccagg ccactgccat ggcagacatt      600

atcgagtatt tccgctggaa ctgggtgggc acaattgctg ctgatgatga ctacggccgg      660

ccagggattg agaagtttcg agaggaagct gaggagaggg acatctgcat cgacttcagt      720

gaactcatct cccagtattc tgatgaagaa gagatccagc aagtggtgga ggtgatccag      780

aattccacag ccaaagtcat tgttgttttc tctagtggcc cagaccttga accccttatc      840

aaggagattg tccggcgtaa tatcacaggg aggatctggc tggccagcga ggcctgggcc      900

agctcttcct tgattgccat gcccgagtac ttccatgtgg ttggaggcac cattggattc      960

gctctgaagg ctggacagat cccaggtttc cgggaattcc tgcagaaagt ccatcccaga     1020

aagtctgtcc acaatggttt tgccaaggag ttttgggaag aaacctttaa ctgccacctc     1080

caagaaggtg ctaaaggacc tttagcactg gacactttcc tgagaggtca tgaagaaggt     1140

ggtggcagga taagcaatag ctccactgcc ttgcgacctc tctgtacagg ggacgagaac     1200

atcagcagcg tggagacccc ttacatggat tatacacatt tacggatatc ctacaatgtc     1260

tacttagcgg tctattccat tgctcatgcc ctgcaagata tatatacatg cttacctgga     1320

agagggctct tcaccaatgg ttcctgcgca gatatcaaga aggttgaggc ttggcaggtc     1380

ctgaagcacc tacggcacct aaactttacc aacaatatgg gggagcaggt gactttcgat     1440

gaatgtgggg acctggtggg gaactattcc atcatcaact ggcacctctc tccagaggat     1500

ggctccatag tgtttaagga agtcggatat tacaacgtct atgccaagaa aggagaaagg     1560

ctcttcatca atgaggagaa aatcctgtgg agtggattct ccagggaggt acctttctcc     1620

aactgcagtc gagactgcct ggcagggacc cggaaaggaa tcattgaggg ggagcccacc     1680

tgctgctttg agtgtgtgga atgtcctgat ggggagtaca gtgatgaaac agatgcaagt     1740

gcctgtgaca agtgccccga tgacttctgg tccaatgaga accacacttc ttgcattgcc     1800

aaggagattg agtttctgtc ctggacggag ccctttggga ttgcactcac tctctttgct     1860

gtgctgggca ttttcctgac agccttcgtg ctgggtgtct tcctcaagtt ccgtaacaca     1920

cccattgtca aggctaccaa tcgagagctc tcctacctcc tcctcttctc cttgctctgc     1980

tgcttctcca gctccctgtt cttcattggt gagccccagg actggacatg ccgcctgcgc     2040

cagccagcct ttggcatcag cttcgtgctc tgcatatcat gcatcctagt gaaaaccaac     2100

cgtgtcctcc tggtgtttga ggccaagatc cccacgagct tccaccgcaa gtggtggggg     2160

ctcaacctgc agttcctgct ggtcttcctc tgcaccttca tgcagattgt catctgtgtg     2220

atctggctct acactgcacc accctcaagc taccgcaacc acgagctgga ggatgagatc     2280

atctttatca catgccacga gggctcgctc atggccctgg gcttcttaat tggctacacc     2340

tgcctactgg ctgccatctg cttcttcttt gccttcaagt cccggaagct gccagagaat     2400

ttcaatgaag ccaagttcat caccttcagc atgctcatct tcttcatcgt ctggatctcc     2460

ttcatcccag cctatgccag cacctatggc aagtttgtct ctgccgtgga agtgatcgcc     2520

atcctggcag ccagctttgg cttgctggcc tgcatcttct tcaacaaggt ctacatcatc     2580

ctcttcaagc catcacgtaa caccatcgag gaggtgcgct gcagcactgc tgcccatgct     2640

ttcaaagtag cagcccgggc cacgctgcgc cgcagcaacg tctctcgcaa gcggtccagc     2700

agccttgggg gctccacggg atccacaccc tcttcctcca tcagcagtaa gagcaacagt     2760

gaagacccct tcccacagcc cgagaggcaa aagcagcagc agccactggc cctgacccaa     2820

caagagcagc agccgcagcc acagcagccc tcgtccctac agcagcagcc acagccacag     2880

ccacagccca gatgcaagca gaaagtcatt ttcggcagtg gcacagtcac cttctcactg     2940

agctttgatg agcctcagaa gagtgccatg gctcacagga attctatgca ccagaactcc     3000

ctggaggccc agaaaagcaa tgagaccctc accagacacc aggcattact cccactacag     3060

tgcggggaga cagactcaga actgagtgcc caggagagag gtcttcaagg gcctgtagat     3120

ggggacttcc gaccagagat ggaggaccct gaagagatgt ccccagcgct tgtagtgtcc     3180

agttcacaaa gctttgtcat cagtggtggt ggcagcactg tcacagaaaa tatactgcat     3240

tca                                                                   3243


