                         SEQUENCE LISTING

<110>  Alder Biopharmaceuticals, Inc.
 
<120>  Anti-PACAP Antibodies and Uses Thereof

<130>  43257.6213

<140>  TBD
<141>  2017-04-14

<150>  62/322,939 
<151>  2016-04-15

<150>  62/322,957 
<151>  2016-04-15

<150>  62/323,495 
<151>  2016-04-15

<150>  62/323,573 
<151>  2016-04-15

<150>  62/366,902 
<151>  2016-07-26

<150>  62/408,347 
<151>  2016-10-14

<160>  1246

<170>  PatentIn version 3.5

<210>  1
<211>  443
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Ser Ala Val 
            20                  25                  30          


Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Ser Ile Val Ala Ser Gly Thr Thr Tyr Tyr Ala Ser Trp Ala Asn Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr Met Asp Leu Lys Met 
65                  70                  75                  80  


Thr Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Gly 
                85                  90                  95      


Gly Gly Glu Phe Phe Ile Trp Gly Pro Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
        115                 120                 125             


Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
    130                 135                 140                 


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
145                 150                 155                 160 


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
                165                 170                 175     


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
            180                 185                 190         


Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
        195                 200                 205             


Ala Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
    210                 215                 220                 


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
225                 230                 235                 240 


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
                245                 250                 255     


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
            260                 265                 270         


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
        275                 280                 285             


Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
    290                 295                 300                 


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
305                 310                 315                 320 


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
                325                 330                 335     


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
            340                 345                 350         


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
        355                 360                 365             


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
    370                 375                 380                 


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
385                 390                 395                 400 


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
                405                 410                 415     


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
            420                 425                 430         


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440             


<210>  2
<211>  113
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  2

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Ser Ala Val 
            20                  25                  30          


Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Ser Ile Val Ala Ser Gly Thr Thr Tyr Tyr Ala Ser Trp Ala Asn Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr Met Asp Leu Lys Met 
65                  70                  75                  80  


Thr Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Gly 
                85                  90                  95      


Gly Gly Glu Phe Phe Ile Trp Gly Pro Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  3
<211>  29
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  3

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser 
            20                  25                  


<210>  4
<211>  5
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  4

Ser Ala Val Met Asn 
1               5   


<210>  5
<211>  14
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  5

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
1               5                   10                  


<210>  6
<211>  16
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  6

Ser Ile Val Ala Ser Gly Thr Thr Tyr Tyr Ala Ser Trp Ala Asn Gly 
1               5                   10                  15      


<210>  7
<211>  31
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  7

Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr Met Asp Leu Lys Met 
1               5                   10                  15      


Thr Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg 
            20                  25                  30      


<210>  8
<211>  7
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  8

Gly Gly Gly Glu Phe Phe Ile 
1               5           


<210>  9
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  9

Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  10
<211>  330
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  10

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Ala 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  11
<211>  1329
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  11
cagtcggtgg aggagtccgg gggtcgcctg gtcacgcctg ggacacccct gacactcacc       60

tgcaccgtct ctggattctc cctcagtagc gctgtaatga attgggtccg ccaggctcca      120

gggaaggggc tggaatggat cggaagtatt gttgctagtg gtaccacata ctacgcgagc      180

tgggcgaacg gccgattcac catctccaaa acctcgtcga ccacgatgga tctgaaaatg      240

accagtccga caaccgagga cacggccacc tatttctgtg ccagaggggg aggggaattt      300

ttcatctggg gcccggggac cctcgtcacc gtctcgagcg cctccaccaa gggcccatcg      360

gtcttccccc tggcaccctc ctccaagagc acctctgggg gcacagcggc cctgggctgc      420

ctggtcaagg actacttccc cgaaccggtg acggtgtcgt ggaactcagg cgccctgacc      480

agcggcgtgc acaccttccc ggctgtccta cagtcctcag gactctactc cctcagcagc      540

gtggtgaccg tgccctccag cagcttgggc acccagacct acatctgcaa cgtgaatcac      600

aagcccagca acaccaaggt ggacgcgaga gttgagccca aatcttgtga caaaactcac      660

acatgcccac cgtgcccagc acctgaactc ctggggggac cgtcagtctt cctcttcccc      720

ccaaaaccca aggacaccct catgatctcc cggacccctg aggtcacatg cgtggtggtg      780

gacgtgagcc acgaagaccc tgaggtcaag ttcaactggt acgtggacgg cgtggaggtg      840

cataatgcca agacaaagcc gcgggaggag cagtacgcca gcacgtaccg tgtggtcagc      900

gtcctcaccg tcctgcacca ggactggctg aatggcaagg agtacaagtg caaggtctcc      960

aacaaagccc tcccagcccc catcgagaaa accatctcca aagccaaagg gcagccccga     1020

gaaccacagg tgtacaccct gcccccatcc cgggaggaga tgaccaagaa ccaggtcagc     1080

ctgacctgcc tggtcaaagg cttctatccc agcgacatcg ccgtggagtg ggagagcaat     1140

gggcagccgg agaacaacta caagaccacg cctcccgtgc tggactccga cggctccttc     1200

ttcctctaca gcaagctcac cgtggacaag agcaggtggc agcaggggaa cgtcttctca     1260

tgctccgtga tgcatgaggc tctgcacaac cactacacgc agaagagcct ctccctgtct     1320

ccgggtaaa                                                             1329


<210>  12
<211>  339
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  12
cagtcggtgg aggagtccgg gggtcgcctg gtcacgcctg ggacacccct gacactcacc       60

tgcaccgtct ctggattctc cctcagtagc gctgtaatga attgggtccg ccaggctcca      120

gggaaggggc tggaatggat cggaagtatt gttgctagtg gtaccacata ctacgcgagc      180

tgggcgaacg gccgattcac catctccaaa acctcgtcga ccacgatgga tctgaaaatg      240

accagtccga caaccgagga cacggccacc tatttctgtg ccagaggggg aggggaattt      300

ttcatctggg gcccggggac cctcgtcacc gtctcgagc                             339


<210>  13
<211>  87
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  13
cagtcggtgg aggagtccgg gggtcgcctg gtcacgcctg ggacacccct gacactcacc       60

tgcaccgtct ctggattctc cctcagt                                           87


<210>  14
<211>  15
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  14
agcgctgtaa tgaat                                                        15


<210>  15
<211>  42
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  15
tgggtccgcc aggctccagg gaaggggctg gaatggatcg ga                          42


<210>  16
<211>  48
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  16
agtattgttg ctagtggtac cacatactac gcgagctggg cgaacggc                    48


<210>  17
<211>  93
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  17
cgattcacca tctccaaaac ctcgtcgacc acgatggatc tgaaaatgac cagtccgaca       60

accgaggaca cggccaccta tttctgtgcc aga                                    93


<210>  18
<211>  21
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  18
gggggagggg aatttttcat c                                                 21


<210>  19
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  19
tggggcccgg ggaccctcgt caccgtctcg agc                                    33


<210>  20
<211>  990
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  20
gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg       60

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      240

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacgcgag agttgagccc      300

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      360

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      420

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      480

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacgcc      540

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      600

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc      660

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggaggag      720

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc      780

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg      840

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg      900

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg      960

cagaagagcc tctccctgtc tccgggtaaa                                       990


<210>  21
<211>  216
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  21

Asp Pro Val Met Thr Gln Thr Pro Ser Ser Thr Ser Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Ser Cys Gln Ser Ser Glu Ser Val Tyr Ser Asn 
            20                  25                  30          


Tyr Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Asn Phe Leu 
        35                  40                  45              


Ile Tyr Gln Ala Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Lys 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Thr Asp Leu Glu 
65                  70                  75                  80  


Cys Asp Asp Ala Ala Thr Tyr Tyr Cys Ala Gly Gly Tyr Ser Glu Asn 
                85                  90                  95      


Ile Val Gly Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg Thr Val 
            100                 105                 110         


Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys 
        115                 120                 125             


Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg 
    130                 135                 140                 


Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn 
145                 150                 155                 160 


Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser 
                165                 170                 175     


Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys 
            180                 185                 190         


Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr 
        195                 200                 205             


Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215     


<210>  22
<211>  110
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  22

Asp Pro Val Met Thr Gln Thr Pro Ser Ser Thr Ser Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Ser Cys Gln Ser Ser Glu Ser Val Tyr Ser Asn 
            20                  25                  30          


Tyr Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Asn Phe Leu 
        35                  40                  45              


Ile Tyr Gln Ala Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Lys 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Thr Asp Leu Glu 
65                  70                  75                  80  


Cys Asp Asp Ala Ala Thr Tyr Tyr Cys Ala Gly Gly Tyr Ser Glu Asn 
                85                  90                  95      


Ile Val Gly Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg 
            100                 105                 110 


<210>  23
<211>  23
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  23

Asp Pro Val Met Thr Gln Thr Pro Ser Ser Thr Ser Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Ser Cys 
            20              


<210>  24
<211>  12
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  24

Gln Ser Ser Glu Ser Val Tyr Ser Asn Tyr Leu Ser 
1               5                   10          


<210>  25
<211>  15
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  25

Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Asn Phe Leu Ile Tyr 
1               5                   10                  15  


<210>  26
<211>  7
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  26

Gln Ala Ser Asn Leu Ala Ser 
1               5           


<210>  27
<211>  32
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  27

Gly Val Pro Ser Arg Phe Lys Gly Ser Gly Ser Gly Thr Gln Phe Thr 
1               5                   10                  15      


Leu Thr Ile Thr Asp Leu Glu Cys Asp Asp Ala Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  28
<211>  10
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  28

Ala Gly Gly Tyr Ser Glu Asn Ile Val Gly 
1               5                   10  


<210>  29
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  29

Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg 
1               5                   10      


<210>  30
<211>  106
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  30

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105     


<210>  31
<211>  648
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  31
gaccctgtga tgacccagac tccatcttcc acgtctgcgg ctgtgggagg cacagtcacc       60

atcagttgcc agtccagtga gagtgtttat agtaactact tatcctggta tcagcagaaa      120

ccagggcagc ctcccaactt cctgatctac caggcatcca atttggcatc tggggtccca      180

tcgcggttca aaggcagtgg atctgggaca cagttcactc tcaccatcac cgacctggag      240

tgtgacgatg ccgccactta ttactgtgca ggcggttata gtgaaaacat tgttggtttc      300

ggcggaggga ccgaggtggt ggtcaaacgt acggtagcgg ccccatctgt cttcatcttc      360

ccgccatctg atgagcagtt gaaatctgga actgcctctg ttgtgtgcct gctgaataac      420

ttctatccca gagaggccaa agtacagtgg aaggtggata acgccctcca atcgggtaac      480

tcccaggaga gtgtcacaga gcaggacagc aaggacagca cctacagcct cagcagcacc      540

ctgacgctga gcaaagcaga ctacgagaaa cacaaagtct acgcctgcga agtcacccat      600

cagggcctga gctcgcccgt cacaaagagc ttcaacaggg gagagtgt                   648


<210>  32
<211>  330
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  32
gaccctgtga tgacccagac tccatcttcc acgtctgcgg ctgtgggagg cacagtcacc       60

atcagttgcc agtccagtga gagtgtttat agtaactact tatcctggta tcagcagaaa      120

ccagggcagc ctcccaactt cctgatctac caggcatcca atttggcatc tggggtccca      180

tcgcggttca aaggcagtgg atctgggaca cagttcactc tcaccatcac cgacctggag      240

tgtgacgatg ccgccactta ttactgtgca ggcggttata gtgaaaacat tgttggtttc      300

ggcggaggga ccgaggtggt ggtcaaacgt                                       330


<210>  33
<211>  69
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  33
gaccctgtga tgacccagac tccatcttcc acgtctgcgg ctgtgggagg cacagtcacc       60

atcagttgc                                                               69


<210>  34
<211>  36
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  34
cagtccagtg agagtgttta tagtaactac ttatcc                                 36


<210>  35
<211>  45
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  35
tggtatcagc agaaaccagg gcagcctccc aacttcctga tctac                       45


<210>  36
<211>  21
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  36
caggcatcca atttggcatc t                                                 21


<210>  37
<211>  96
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  37
ggggtcccat cgcggttcaa aggcagtgga tctgggacac agttcactct caccatcacc       60

gacctggagt gtgacgatgc cgccacttat tactgt                                 96


<210>  38
<211>  30
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  38
gcaggcggtt atagtgaaaa cattgttggt                                        30


<210>  39
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  39
ttcggcggag ggaccgaggt ggtggtcaaa cgt                                    33


<210>  40
<211>  318
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  40
acggtagcgg ccccatctgt cttcatcttc ccgccatctg atgagcagtt gaaatctgga       60

actgcctctg ttgtgtgcct gctgaataac ttctatccca gagaggccaa agtacagtgg      120

aaggtggata acgccctcca atcgggtaac tcccaggaga gtgtcacaga gcaggacagc      180

aaggacagca cctacagcct cagcagcacc ctgacgctga gcaaagcaga ctacgagaaa      240

cacaaagtct acgcctgcga agtcacccat cagggcctga gctcgcccgt cacaaagagc      300

ttcaacaggg gagagtgt                                                    318


<210>  41
<211>  445
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  41

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Ala 
            20                  25                  30          


Val Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ser Ile Val Ala Ser Gly Thr Thr Tyr Tyr Ala Ser Ser Ala Asn 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Gly Gly Glu Phe Phe Ile Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
        115                 120                 125             


Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val 
    130                 135                 140                 


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
145                 150                 155                 160 


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
                165                 170                 175     


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
            180                 185                 190         


Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys 
        195                 200                 205             


Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys 
    210                 215                 220                 


Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
225                 230                 235                 240 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                245                 250                 255     


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            260                 265                 270         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        275                 280                 285             


Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu 
    290                 295                 300                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
305                 310                 315                 320 


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                325                 330                 335     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            340                 345                 350         


Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        355                 360                 365             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    370                 375                 380                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
385                 390                 395                 400 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                405                 410                 415     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            420                 425                 430         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445 


<210>  42
<211>  115
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  42

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Ala 
            20                  25                  30          


Val Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ser Ile Val Ala Ser Gly Thr Thr Tyr Tyr Ala Ser Ser Ala Asn 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Gly Gly Glu Phe Phe Ile Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  43
<211>  30
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  43

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser 
            20                  25                  30  


<210>  44
<211>  5
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  44

Ser Ala Val Met Asn 
1               5   


<210>  45
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  45

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
1               5                   10                  


<210>  46
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  46

Ser Ile Val Ala Ser Gly Thr Thr Tyr Tyr Ala Ser Ser Ala Asn Gly 
1               5                   10                  15      


<210>  47
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  47

Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  48
<211>  7
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  48

Gly Gly Gly Glu Phe Phe Ile 
1               5           


<210>  49
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  49

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  50
<211>  330
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  50

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  51
<211>  1335
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  51
gaggtgcagc ttgtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccgtcagt agcgctgtaa tgaattgggt ccgtcaggct      120

ccagggaagg ggctggagtg gatcggaagt attgttgcta gtggtaccac atactacgct      180

agctctgcta acggccgatt caccatctcc agagacaatt ccaagaacac cctgtatctt      240

caaatgaaca gcctgagagc tgaggacact gctgtgtatt actgtgctag agggggaggg      300

gaatttttca tctggggcca agggaccctc gtcaccgtct cgagcgcctc caccaagggc      360

ccatcggtct tccccctggc accctcctcc aagagcacct ctgggggcac agcggccctg      420

ggctgcctgg tcaaggacta cttccccgaa ccggtgacgg tgtcgtggaa ctcaggcgcc      480

ctgaccagcg gcgtgcacac cttcccggct gtcctacagt cctcaggact ctactccctc      540

agcagcgtgg tgaccgtgcc ctccagcagc ttgggcaccc agacctacat ctgcaacgtg      600

aatcacaagc ccagcaacac caaggtggac aagaaagttg agcccaaatc ttgtgacaaa      660

actcacacat gcccaccgtg cccagcacct gaactcctgg ggggaccgtc agtcttcctc      720

ttccccccaa aacccaagga caccctcatg atctcccgga cccctgaggt cacatgcgtg      780

gtggtggacg tgagccacga agaccctgag gtcaagttca actggtacgt ggacggcgtg      840

gaggtgcata atgccaagac aaagccgcgg gaggagcagt acgccagcac gtaccgtgtg      900

gtcagcgtcc tcaccgtcct gcaccaggac tggctgaatg gcaaggagta caagtgcaag      960

gtctccaaca aagccctccc agcccccatc gagaaaacca tctccaaagc caaagggcag     1020

ccccgagaac cacaggtgta caccctgccc ccatcccggg aggagatgac caagaaccag     1080

gtcagcctga cctgcctggt caaaggcttc tatcccagcg acatcgccgt ggagtgggag     1140

agcaatgggc agccggagaa caactacaag accacgcctc ccgtgctgga ctccgacggc     1200

tccttcttcc tctacagcaa gctcaccgtg gacaagagca ggtggcagca ggggaacgtc     1260

ttctcatgct ccgtgatgca tgaggctctg cacaaccact acacgcagaa gagcctctcc     1320

ctgtctccgg gtaaa                                                      1335


<210>  52
<211>  345
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  52
gaggtgcagc ttgtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccgtcagt agcgctgtaa tgaattgggt ccgtcaggct      120

ccagggaagg ggctggagtg gatcggaagt attgttgcta gtggtaccac atactacgct      180

agctctgcta acggccgatt caccatctcc agagacaatt ccaagaacac cctgtatctt      240

caaatgaaca gcctgagagc tgaggacact gctgtgtatt actgtgctag agggggaggg      300

gaatttttca tctggggcca agggaccctc gtcaccgtct cgagc                      345


<210>  53
<211>  90
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  53
gaggtgcagc ttgtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccgtcagt                                        90


<210>  54
<211>  15
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  54
agcgctgtaa tgaat                                                        15


<210>  55
<211>  42
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  55
tgggtccgtc aggctccagg gaaggggctg gagtggatcg ga                          42


<210>  56
<211>  48
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  56
agtattgttg ctagtggtac cacatactac gctagctctg ctaacggc                    48


<210>  57
<211>  96
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  57
cgattcacca tctccagaga caattccaag aacaccctgt atcttcaaat gaacagcctg       60

agagctgagg acactgctgt gtattactgt gctaga                                 96


<210>  58
<211>  21
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  58
gggggagggg aatttttcat c                                                 21


<210>  59
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  59
tggggccaag ggaccctcgt caccgtctcg agc                                    33


<210>  60
<211>  990
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  60
gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg       60

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      240

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttgagccc      300

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      360

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      420

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      480

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacgcc      540

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      600

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc      660

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggaggag      720

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc      780

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg      840

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg      900

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg      960

cagaagagcc tctccctgtc tccgggtaaa                                       990


<210>  61
<211>  216
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  61

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ser Ser Glu Ser Val Tyr Ser Asn 
            20                  25                  30          


Tyr Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Phe Leu 
        35                  40                  45              


Ile Tyr Gln Ala Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Ala Gly Gly Tyr Ser Glu Asn 
                85                  90                  95      


Ile Val Gly Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val 
            100                 105                 110         


Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys 
        115                 120                 125             


Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg 
    130                 135                 140                 


Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn 
145                 150                 155                 160 


Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser 
                165                 170                 175     


Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys 
            180                 185                 190         


Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr 
        195                 200                 205             


Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215     


<210>  62
<211>  110
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  62

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ser Ser Glu Ser Val Tyr Ser Asn 
            20                  25                  30          


Tyr Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Phe Leu 
        35                  40                  45              


Ile Tyr Gln Ala Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Ala Gly Gly Tyr Ser Glu Asn 
                85                  90                  95      


Ile Val Gly Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110 


<210>  63
<211>  23
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  63

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys 
            20              


<210>  64
<211>  12
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  64

Gln Ser Ser Glu Ser Val Tyr Ser Asn Tyr Leu Ser 
1               5                   10          


<210>  65
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  65

Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Phe Leu Ile Tyr 
1               5                   10                  15  


<210>  66
<211>  7
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  66

Gln Ala Ser Asn Leu Ala Ser 
1               5           


<210>  67
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  67

Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  68
<211>  10
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  68

Ala Gly Gly Tyr Ser Glu Asn Ile Val Gly 
1               5                   10  


<210>  69
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  69

Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
1               5                   10      


<210>  70
<211>  106
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  70

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105     


<210>  71
<211>  648
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  71
gacatccaga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgtc agtccagtga gagtgtttat agtaactact tatcctggta tcagcagaaa      120

ccaggaaaag cccctaagtt cctgatctat caggcatcca atttggcatc tggagtccca      180

tcaaggttca gcggcagtgg atctggaaca gaattcactc tcaccatcag cagcctgcag      240

cctgatgatt ttgcaactta ctactgtgca ggcggttata gtgaaaacat tgttggtttc      300

ggcggaggaa ccaaggtgga aatcaaacgt acggtagcgg ccccatctgt cttcatcttc      360

ccgccatctg atgagcagtt gaaatctgga actgcctctg ttgtgtgcct gctgaataac      420

ttctatccca gagaggccaa agtacagtgg aaggtggata acgccctcca atcgggtaac      480

tcccaggaga gtgtcacaga gcaggacagc aaggacagca cctacagcct cagcagcacc      540

ctgacgctga gcaaagcaga ctacgagaaa cacaaagtct acgcctgcga agtcacccat      600

cagggcctga gctcgcccgt cacaaagagc ttcaacaggg gagagtgt                   648


<210>  72
<211>  330
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  72
gacatccaga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgtc agtccagtga gagtgtttat agtaactact tatcctggta tcagcagaaa      120

ccaggaaaag cccctaagtt cctgatctat caggcatcca atttggcatc tggagtccca      180

tcaaggttca gcggcagtgg atctggaaca gaattcactc tcaccatcag cagcctgcag      240

cctgatgatt ttgcaactta ctactgtgca ggcggttata gtgaaaacat tgttggtttc      300

ggcggaggaa ccaaggtgga aatcaaacgt                                       330


<210>  73
<211>  69
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  73
gacatccaga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgt                                                               69


<210>  74
<211>  36
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  74
cagtccagtg agagtgttta tagtaactac ttatcc                                 36


<210>  75
<211>  45
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  75
tggtatcagc agaaaccagg aaaagcccct aagttcctga tctat                       45


<210>  76
<211>  21
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  76
caggcatcca atttggcatc t                                                 21


<210>  77
<211>  96
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  77
ggagtcccat caaggttcag cggcagtgga tctggaacag aattcactct caccatcagc       60

agcctgcagc ctgatgattt tgcaacttac tactgt                                 96


<210>  78
<211>  30
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  78
gcaggcggtt atagtgaaaa cattgttggt                                        30


<210>  79
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  79
ttcggcggag gaaccaaggt ggaaatcaaa cgt                                    33


<210>  80
<211>  318
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  80
acggtagcgg ccccatctgt cttcatcttc ccgccatctg atgagcagtt gaaatctgga       60

actgcctctg ttgtgtgcct gctgaataac ttctatccca gagaggccaa agtacagtgg      120

aaggtggata acgccctcca atcgggtaac tcccaggaga gtgtcacaga gcaggacagc      180

aaggacagca cctacagcct cagcagcacc ctgacgctga gcaaagcaga ctacgagaaa      240

cacaaagtct acgcctgcga agtcacccat cagggcctga gctcgcccgt cacaaagagc      300

ttcaacaggg gagagtgt                                                    318


<210>  81
<211>  443
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  81

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Gly Ala Ala 
            20                  25                  30          


Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Val Ile Gly Asn Ser Gly Ser Thr Tyr Tyr Ala Ser Trp Ala Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr Val Asp Leu Lys Met 
65                  70                  75                  80  


Thr Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Gly 
                85                  90                  95      


Gly Gly Glu Phe Phe Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
        115                 120                 125             


Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
    130                 135                 140                 


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
145                 150                 155                 160 


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
                165                 170                 175     


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
            180                 185                 190         


Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
        195                 200                 205             


Ala Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
    210                 215                 220                 


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
225                 230                 235                 240 


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
                245                 250                 255     


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
            260                 265                 270         


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
        275                 280                 285             


Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
    290                 295                 300                 


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
305                 310                 315                 320 


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
                325                 330                 335     


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
            340                 345                 350         


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
        355                 360                 365             


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
    370                 375                 380                 


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
385                 390                 395                 400 


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
                405                 410                 415     


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
            420                 425                 430         


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440             


<210>  82
<211>  113
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  82

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Gly Ala Ala 
            20                  25                  30          


Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Val Ile Gly Asn Ser Gly Ser Thr Tyr Tyr Ala Ser Trp Ala Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr Val Asp Leu Lys Met 
65                  70                  75                  80  


Thr Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Gly 
                85                  90                  95      


Gly Gly Glu Phe Phe Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  83
<211>  29
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  83

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser 
            20                  25                  


<210>  84
<211>  5
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  84

Gly Ala Ala Met Asn 
1               5   


<210>  85
<211>  14
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  85

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
1               5                   10                  


<210>  86
<211>  16
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  86

Val Ile Gly Asn Ser Gly Ser Thr Tyr Tyr Ala Ser Trp Ala Lys Gly 
1               5                   10                  15      


<210>  87
<211>  31
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  87

Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr Val Asp Leu Lys Met 
1               5                   10                  15      


Thr Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg 
            20                  25                  30      


<210>  88
<211>  7
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  88

Gly Gly Gly Glu Phe Phe Ile 
1               5           


<210>  89
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  89

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  90
<211>  330
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  90

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Ala 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  91
<211>  1329
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  91
cagtcggtgg aggagtccgg gggtcgcctg gtcacgcctg ggacacccct gacactcacc       60

tgcaccgtct ctggattctc cctcagtggc gctgcgatga actgggtccg ccaggctcca      120

gggaaggggc tggaatggat cggagttatt ggtaatagtg gtagcacata ctacgcgtcc      180

tgggcgaaag gccgattcac catctccaaa acctcgtcga ccacggtgga tctgaaaatg      240

accagtccga caaccgagga cacggccacc tatttctgtg ccagaggggg aggggaattt      300

ttcatctggg gccaagggac cctggtcacc gtctcgagcg cctccaccaa gggcccatcg      360

gtcttccccc tggcaccctc ctccaagagc acctctgggg gcacagcggc cctgggctgc      420

ctggtcaagg actacttccc cgaaccggtg acggtgtcgt ggaactcagg cgccctgacc      480

agcggcgtgc acaccttccc ggctgtccta cagtcctcag gactctactc cctcagcagc      540

gtggtgaccg tgccctccag cagcttgggc acccagacct acatctgcaa cgtgaatcac      600

aagcccagca acaccaaggt ggacgcgaga gttgagccca aatcttgtga caaaactcac      660

acatgcccac cgtgcccagc acctgaactc ctggggggac cgtcagtctt cctcttcccc      720

ccaaaaccca aggacaccct catgatctcc cggacccctg aggtcacatg cgtggtggtg      780

gacgtgagcc acgaagaccc tgaggtcaag ttcaactggt acgtggacgg cgtggaggtg      840

cataatgcca agacaaagcc gcgggaggag cagtacgcca gcacgtaccg tgtggtcagc      900

gtcctcaccg tcctgcacca ggactggctg aatggcaagg agtacaagtg caaggtctcc      960

aacaaagccc tcccagcccc catcgagaaa accatctcca aagccaaagg gcagccccga     1020

gaaccacagg tgtacaccct gcccccatcc cgggaggaga tgaccaagaa ccaggtcagc     1080

ctgacctgcc tggtcaaagg cttctatccc agcgacatcg ccgtggagtg ggagagcaat     1140

gggcagccgg agaacaacta caagaccacg cctcccgtgc tggactccga cggctccttc     1200

ttcctctaca gcaagctcac cgtggacaag agcaggtggc agcaggggaa cgtcttctca     1260

tgctccgtga tgcatgaggc tctgcacaac cactacacgc agaagagcct ctccctgtct     1320

ccgggtaaa                                                             1329


<210>  92
<211>  339
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  92
cagtcggtgg aggagtccgg gggtcgcctg gtcacgcctg ggacacccct gacactcacc       60

tgcaccgtct ctggattctc cctcagtggc gctgcgatga actgggtccg ccaggctcca      120

gggaaggggc tggaatggat cggagttatt ggtaatagtg gtagcacata ctacgcgtcc      180

tgggcgaaag gccgattcac catctccaaa acctcgtcga ccacggtgga tctgaaaatg      240

accagtccga caaccgagga cacggccacc tatttctgtg ccagaggggg aggggaattt      300

ttcatctggg gccaagggac cctggtcacc gtctcgagc                             339


<210>  93
<211>  87
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  93
cagtcggtgg aggagtccgg gggtcgcctg gtcacgcctg ggacacccct gacactcacc       60

tgcaccgtct ctggattctc cctcagt                                           87


<210>  94
<211>  15
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  94
ggcgctgcga tgaac                                                        15


<210>  95
<211>  42
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  95
tgggtccgcc aggctccagg gaaggggctg gaatggatcg ga                          42


<210>  96
<211>  48
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  96
gttattggta atagtggtag cacatactac gcgtcctggg cgaaaggc                    48


<210>  97
<211>  93
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  97
cgattcacca tctccaaaac ctcgtcgacc acggtggatc tgaaaatgac cagtccgaca       60

accgaggaca cggccaccta tttctgtgcc aga                                    93


<210>  98
<211>  21
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  98
gggggagggg aatttttcat c                                                 21


<210>  99
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  99
tggggccaag ggaccctggt caccgtctcg agc                                    33


<210>  100
<211>  990
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  100
gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg       60

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      240

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacgcgag agttgagccc      300

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      360

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      420

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      480

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacgcc      540

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      600

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc      660

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggaggag      720

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc      780

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg      840

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg      900

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg      960

cagaagagcc tctccctgtc tccgggtaaa                                       990


<210>  101
<211>  217
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  101

Ala Gln Val Leu Thr Gln Thr Pro Ser Pro Val Ser Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Asn Cys Gln Ser Ser Glu Ser Val Tyr Lys Asn 
            20                  25                  30          


Asn Tyr Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Phe 
        35                  40                  45              


Leu Ile Tyr Gln Ala Ser Asn Leu Ala Asp Gly Val Pro Ser Arg Phe 
    50                  55                  60                  


Lys Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Asp Leu 
65                  70                  75                  80  


Glu Cys Asp Asp Ala Ala Thr Tyr Tyr Cys Ala Gly Gly Tyr Ser Thr 
                85                  90                  95      


Tyr Met Ser Gly Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg Thr 
            100                 105                 110         


Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
        115                 120                 125             


Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
    130                 135                 140                 


Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
145                 150                 155                 160 


Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
                165                 170                 175     


Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
            180                 185                 190         


Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
        195                 200                 205             


Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215         


<210>  102
<211>  111
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  102

Ala Gln Val Leu Thr Gln Thr Pro Ser Pro Val Ser Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Asn Cys Gln Ser Ser Glu Ser Val Tyr Lys Asn 
            20                  25                  30          


Asn Tyr Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Phe 
        35                  40                  45              


Leu Ile Tyr Gln Ala Ser Asn Leu Ala Asp Gly Val Pro Ser Arg Phe 
    50                  55                  60                  


Lys Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Asp Leu 
65                  70                  75                  80  


Glu Cys Asp Asp Ala Ala Thr Tyr Tyr Cys Ala Gly Gly Tyr Ser Thr 
                85                  90                  95      


Tyr Met Ser Gly Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg 
            100                 105                 110     


<210>  103
<211>  23
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  103

Ala Gln Val Leu Thr Gln Thr Pro Ser Pro Val Ser Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Asn Cys 
            20              


<210>  104
<211>  13
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  104

Gln Ser Ser Glu Ser Val Tyr Lys Asn Asn Tyr Leu Ser 
1               5                   10              


<210>  105
<211>  15
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  105

Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Phe Leu Ile Tyr 
1               5                   10                  15  


<210>  106
<211>  7
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  106

Gln Ala Ser Asn Leu Ala Asp 
1               5           


<210>  107
<211>  32
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  107

Gly Val Pro Ser Arg Phe Lys Gly Ser Gly Ser Gly Thr Gln Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Asp Leu Glu Cys Asp Asp Ala Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  108
<211>  10
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  108

Ala Gly Gly Tyr Ser Thr Tyr Met Ser Gly 
1               5                   10  


<210>  109
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  109

Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg 
1               5                   10      


<210>  110
<211>  106
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  110

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105     


<210>  111
<211>  651
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  111
gcccaagtgc tgacccagac tccatcccca gtgtctgcag ctgtgggagg caccgtcacc       60

atcaattgcc agtccagtga gagtgtttat aagaacaact acttatcctg gtatcagcag      120

aaaccagggc agcctcccaa gttcctgatc taccaggcat ccaatttggc agatggggtc      180

ccatcgcggt tcaaaggcag tggatctggg acacagttca ctctcaccat cagcgacctg      240

gagtgtgacg atgccgccac ttattactgt gcaggcggtt atagtactta tatgtctggt      300

ttcggcggag ggaccgaggt ggtggtcaaa cgtacggtag cggccccatc tgtcttcatc      360

ttcccgccat ctgatgagca gttgaaatct ggaactgcct ctgttgtgtg cctgctgaat      420

aacttctatc ccagagaggc caaagtacag tggaaggtgg ataacgccct ccaatcgggt      480

aactcccagg agagtgtcac agagcaggac agcaaggaca gcacctacag cctcagcagc      540

accctgacgc tgagcaaagc agactacgag aaacacaaag tctacgcctg cgaagtcacc      600

catcagggcc tgagctcgcc cgtcacaaag agcttcaaca ggggagagtg t               651


<210>  112
<211>  333
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  112
gcccaagtgc tgacccagac tccatcccca gtgtctgcag ctgtgggagg caccgtcacc       60

atcaattgcc agtccagtga gagtgtttat aagaacaact acttatcctg gtatcagcag      120

aaaccagggc agcctcccaa gttcctgatc taccaggcat ccaatttggc agatggggtc      180

ccatcgcggt tcaaaggcag tggatctggg acacagttca ctctcaccat cagcgacctg      240

gagtgtgacg atgccgccac ttattactgt gcaggcggtt atagtactta tatgtctggt      300

ttcggcggag ggaccgaggt ggtggtcaaa cgt                                   333


<210>  113
<211>  69
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  113
gcccaagtgc tgacccagac tccatcccca gtgtctgcag ctgtgggagg caccgtcacc       60

atcaattgc                                                               69


<210>  114
<211>  39
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  114
cagtccagtg agagtgttta taagaacaac tacttatcc                              39


<210>  115
<211>  45
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  115
tggtatcagc agaaaccagg gcagcctccc aagttcctga tctac                       45


<210>  116
<211>  21
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  116
caggcatcca atttggcaga t                                                 21


<210>  117
<211>  96
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  117
ggggtcccat cgcggttcaa aggcagtgga tctgggacac agttcactct caccatcagc       60

gacctggagt gtgacgatgc cgccacttat tactgt                                 96


<210>  118
<211>  30
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  118
gcaggcggtt atagtactta tatgtctggt                                        30


<210>  119
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  119
ttcggcggag ggaccgaggt ggtggtcaaa cgt                                    33


<210>  120
<211>  318
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  120
acggtagcgg ccccatctgt cttcatcttc ccgccatctg atgagcagtt gaaatctgga       60

actgcctctg ttgtgtgcct gctgaataac ttctatccca gagaggccaa agtacagtgg      120

aaggtggata acgccctcca atcgggtaac tcccaggaga gtgtcacaga gcaggacagc      180

aaggacagca cctacagcct cagcagcacc ctgacgctga gcaaagcaga ctacgagaaa      240

cacaaagtct acgcctgcga agtcacccat cagggcctga gctcgcccgt cacaaagagc      300

ttcaacaggg gagagtgt                                                    318


<210>  121
<211>  443
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  121

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Ser Ala Ala 
            20                  25                  30          


Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Ile Ile Asp Asn Thr Ala Gly Thr Tyr Tyr Ala Pro Trp Ala Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr Val Asp Leu Lys Met 
65                  70                  75                  80  


Thr Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Gly 
                85                  90                  95      


Gly Gly Glu Phe Phe Ile Trp Gly Pro Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
        115                 120                 125             


Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
    130                 135                 140                 


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
145                 150                 155                 160 


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
                165                 170                 175     


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
            180                 185                 190         


Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
        195                 200                 205             


Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
    210                 215                 220                 


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
225                 230                 235                 240 


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
                245                 250                 255     


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
            260                 265                 270         


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
        275                 280                 285             


Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
    290                 295                 300                 


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
305                 310                 315                 320 


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
                325                 330                 335     


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
            340                 345                 350         


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
        355                 360                 365             


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
    370                 375                 380                 


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
385                 390                 395                 400 


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
                405                 410                 415     


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
            420                 425                 430         


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440             


<210>  122
<211>  113
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  122

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Ser Ala Ala 
            20                  25                  30          


Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Ile Ile Asp Asn Thr Ala Gly Thr Tyr Tyr Ala Pro Trp Ala Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr Val Asp Leu Lys Met 
65                  70                  75                  80  


Thr Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Gly 
                85                  90                  95      


Gly Gly Glu Phe Phe Ile Trp Gly Pro Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  123
<211>  29
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  123

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser 
            20                  25                  


<210>  124
<211>  5
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  124

Ser Ala Ala Met Asn 
1               5   


<210>  125
<211>  14
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  125

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
1               5                   10                  


<210>  126
<211>  16
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  126

Ile Ile Asp Asn Thr Ala Gly Thr Tyr Tyr Ala Pro Trp Ala Lys Gly 
1               5                   10                  15      


<210>  127
<211>  31
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  127

Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr Val Asp Leu Lys Met 
1               5                   10                  15      


Thr Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg 
            20                  25                  30      


<210>  128
<211>  7
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  128

Gly Gly Gly Glu Phe Phe Ile 
1               5           


<210>  129
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  129

Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  130
<211>  330
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  130

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  131
<211>  1329
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  131
cagtcggtgg aggagtccgg gggtcgcctg gtcacgcctg ggacacccct gacactcacc       60

tgcaccgtct ctggattctc cctcagtagc gctgcaatga actgggtccg ccaggctcca      120

gggaaggggc tggaatggat cggaattatt gataatactg ctggcacata ttacgcgccc      180

tgggcgaaag gccgattcac catctccaaa acctcgtcga ccacggtgga tctgaaaatg      240

accagtccga caaccgagga cacggccacc tatttctgtg ccagaggggg aggggaattt      300

ttcatctggg gcccgggcac cctcgtcacc gtctcgagcg cctccaccaa gggcccatcg      360

gtcttccccc tggcaccctc ctccaagagc acctctgggg gcacagcggc cctgggctgc      420

ctggtcaagg actacttccc cgaaccggtg acggtgtcgt ggaactcagg cgccctgacc      480

agcggcgtgc acaccttccc ggctgtccta cagtcctcag gactctactc cctcagcagc      540

gtggtgaccg tgccctccag cagcttgggc acccagacct acatctgcaa cgtgaatcac      600

aagcccagca acaccaaggt ggacaagaaa gttgagccca aatcttgtga caaaactcac      660

acatgcccac cgtgcccagc acctgaactc ctggggggac cgtcagtctt cctcttcccc      720

ccaaaaccca aggacaccct catgatctcc cggacccctg aggtcacatg cgtggtggtg      780

gacgtgagcc acgaagaccc tgaggtcaag ttcaactggt acgtggacgg cgtggaggtg      840

cataatgcca agacaaagcc gcgggaggag cagtacgcca gcacgtaccg tgtggtcagc      900

gtcctcaccg tcctgcacca ggactggctg aatggcaagg agtacaagtg caaggtctcc      960

aacaaagccc tcccagcccc catcgagaaa accatctcca aagccaaagg gcagccccga     1020

gaaccacagg tgtacaccct gcccccatcc cgggaggaga tgaccaagaa ccaggtcagc     1080

ctgacctgcc tggtcaaagg cttctatccc agcgacatcg ccgtggagtg ggagagcaat     1140

gggcagccgg agaacaacta caagaccacg cctcccgtgc tggactccga cggctccttc     1200

ttcctctaca gcaagctcac cgtggacaag agcaggtggc agcaggggaa cgtcttctca     1260

tgctccgtga tgcatgaggc tctgcacaac cactacacgc agaagagcct ctccctgtct     1320

ccgggtaaa                                                             1329


<210>  132
<211>  339
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  132
cagtcggtgg aggagtccgg gggtcgcctg gtcacgcctg ggacacccct gacactcacc       60

tgcaccgtct ctggattctc cctcagtagc gctgcaatga actgggtccg ccaggctcca      120

gggaaggggc tggaatggat cggaattatt gataatactg ctggcacata ttacgcgccc      180

tgggcgaaag gccgattcac catctccaaa acctcgtcga ccacggtgga tctgaaaatg      240

accagtccga caaccgagga cacggccacc tatttctgtg ccagaggggg aggggaattt      300

ttcatctggg gcccgggcac cctcgtcacc gtctcgagc                             339


<210>  133
<211>  87
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  133
cagtcggtgg aggagtccgg gggtcgcctg gtcacgcctg ggacacccct gacactcacc       60

tgcaccgtct ctggattctc cctcagt                                           87


<210>  134
<211>  15
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  134
agcgctgcaa tgaac                                                        15


<210>  135
<211>  42
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  135
tgggtccgcc aggctccagg gaaggggctg gaatggatcg ga                          42


<210>  136
<211>  48
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  136
attattgata atactgctgg cacatattac gcgccctggg cgaaaggc                    48


<210>  137
<211>  93
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  137
cgattcacca tctccaaaac ctcgtcgacc acggtggatc tgaaaatgac cagtccgaca       60

accgaggaca cggccaccta tttctgtgcc aga                                    93


<210>  138
<211>  21
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  138
gggggagggg aatttttcat c                                                 21


<210>  139
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  139
tggggcccgg gcaccctcgt caccgtctcg agc                                    33


<210>  140
<211>  990
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  140
gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg       60

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      240

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttgagccc      300

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      360

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      420

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      480

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacgcc      540

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      600

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc      660

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggaggag      720

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc      780

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg      840

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg      900

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg      960

cagaagagcc tctccctgtc tccgggtaaa                                       990


<210>  141
<211>  217
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  141

Ala Gln Val Leu Thr Gln Thr Pro Ser Ser Val Ser Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Asn Cys Gln Ser Ser Gln Ser Val His Asp Gly 
            20                  25                  30          


Ser Tyr Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Asn Phe 
        35                  40                  45              


Leu Ile Tyr Gln Ala Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe 
    50                  55                  60                  


Lys Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Asp Leu 
65                  70                  75                  80  


Glu Cys Asp Asp Ala Ala Thr Tyr Tyr Cys Ala Gly Gly Tyr Ser Ser 
                85                  90                  95      


Asn Ile Cys Gly Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg Thr 
            100                 105                 110         


Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
        115                 120                 125             


Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
    130                 135                 140                 


Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
145                 150                 155                 160 


Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
                165                 170                 175     


Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
            180                 185                 190         


Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
        195                 200                 205             


Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215         


<210>  142
<211>  111
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  142

Ala Gln Val Leu Thr Gln Thr Pro Ser Ser Val Ser Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Asn Cys Gln Ser Ser Gln Ser Val His Asp Gly 
            20                  25                  30          


Ser Tyr Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Asn Phe 
        35                  40                  45              


Leu Ile Tyr Gln Ala Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe 
    50                  55                  60                  


Lys Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Asp Leu 
65                  70                  75                  80  


Glu Cys Asp Asp Ala Ala Thr Tyr Tyr Cys Ala Gly Gly Tyr Ser Ser 
                85                  90                  95      


Asn Ile Cys Gly Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg 
            100                 105                 110     


<210>  143
<211>  23
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  143

Ala Gln Val Leu Thr Gln Thr Pro Ser Ser Val Ser Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Asn Cys 
            20              


<210>  144
<211>  13
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  144

Gln Ser Ser Gln Ser Val His Asp Gly Ser Tyr Leu Ser 
1               5                   10              


<210>  145
<211>  15
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  145

Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Asn Phe Leu Ile Tyr 
1               5                   10                  15  


<210>  146
<211>  7
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  146

Gln Ala Ser Asn Leu Ala Ser 
1               5           


<210>  147
<211>  32
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  147

Gly Val Pro Ser Arg Phe Lys Gly Ser Gly Ser Gly Thr Gln Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Asp Leu Glu Cys Asp Asp Ala Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  148
<211>  10
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  148

Ala Gly Gly Tyr Ser Ser Asn Ile Cys Gly 
1               5                   10  


<210>  149
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  149

Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg 
1               5                   10      


<210>  150
<211>  106
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  150

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105     


<210>  151
<211>  651
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  151
gcgcaagtgc tgacccagac tccatcgtcc gtgtctgcag ctgtgggagg cacagtcacc       60

atcaattgcc agtccagtca gagtgttcat gatggcagct acttatcctg gtatcagcag      120

aaaccagggc agcctcccaa cttcctgatc taccaggcat ccaatttggc atctggggtc      180

ccatcgcggt tcaaaggcag tggatctggg acacagttca ctctcaccat cagcgacctg      240

gagtgtgacg atgccgccac ttattactgt gcaggcggtt atagtagtaa tatttgtggt      300

ttcggcggag ggaccgaggt ggtggtcaaa cgtacggtag cggccccatc tgtcttcatc      360

ttcccgccat ctgatgagca gttgaaatct ggaactgcct ctgttgtgtg cctgctgaat      420

aacttctatc ccagagaggc caaagtacag tggaaggtgg ataacgccct ccaatcgggt      480

aactcccagg agagtgtcac agagcaggac agcaaggaca gcacctacag cctcagcagc      540

accctgacgc tgagcaaagc agactacgag aaacacaaag tctacgcctg cgaagtcacc      600

catcagggcc tgagctcgcc cgtcacaaag agcttcaaca ggggagagtg t               651


<210>  152
<211>  333
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  152
gcgcaagtgc tgacccagac tccatcgtcc gtgtctgcag ctgtgggagg cacagtcacc       60

atcaattgcc agtccagtca gagtgttcat gatggcagct acttatcctg gtatcagcag      120

aaaccagggc agcctcccaa cttcctgatc taccaggcat ccaatttggc atctggggtc      180

ccatcgcggt tcaaaggcag tggatctggg acacagttca ctctcaccat cagcgacctg      240

gagtgtgacg atgccgccac ttattactgt gcaggcggtt atagtagtaa tatttgtggt      300

ttcggcggag ggaccgaggt ggtggtcaaa cgt                                   333


<210>  153
<211>  69
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  153
gcgcaagtgc tgacccagac tccatcgtcc gtgtctgcag ctgtgggagg cacagtcacc       60

atcaattgc                                                               69


<210>  154
<211>  39
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  154
cagtccagtc agagtgttca tgatggcagc tacttatcc                              39


<210>  155
<211>  45
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  155
tggtatcagc agaaaccagg gcagcctccc aacttcctga tctac                       45


<210>  156
<211>  21
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  156
caggcatcca atttggcatc t                                                 21


<210>  157
<211>  96
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  157
ggggtcccat cgcggttcaa aggcagtgga tctgggacac agttcactct caccatcagc       60

gacctggagt gtgacgatgc cgccacttat tactgt                                 96


<210>  158
<211>  30
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  158
gcaggcggtt atagtagtaa tatttgtggt                                        30


<210>  159
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  159
ttcggcggag ggaccgaggt ggtggtcaaa cgt                                    33


<210>  160
<211>  318
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  160
acggtagcgg ccccatctgt cttcatcttc ccgccatctg atgagcagtt gaaatctgga       60

actgcctctg ttgtgtgcct gctgaataac ttctatccca gagaggccaa agtacagtgg      120

aaggtggata acgccctcca atcgggtaac tcccaggaga gtgtcacaga gcaggacagc      180

aaggacagca cctacagcct cagcagcacc ctgacgctga gcaaagcaga ctacgagaaa      240

cacaaagtct acgcctgcga agtcacccat cagggcctga gctcgcccgt cacaaagagc      300

ttcaacaggg gagagtgt                                                    318


<210>  161
<211>  443
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  161

Gln Ser Val Glu Ala Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Ser Ala Ala 
            20                  25                  30          


Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Phe Ile Glu Tyr Ser Lys Asn Ile Val Tyr Ala Ser Trp Ala Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Lys Val Ser Ser Thr Thr Val Asp Leu Lys Met 
65                  70                  75                  80  


Thr Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Gly 
                85                  90                  95      


Gly Gly Glu Phe Phe Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
        115                 120                 125             


Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
    130                 135                 140                 


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
145                 150                 155                 160 


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
                165                 170                 175     


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
            180                 185                 190         


Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
        195                 200                 205             


Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
    210                 215                 220                 


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
225                 230                 235                 240 


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
                245                 250                 255     


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
            260                 265                 270         


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
        275                 280                 285             


Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
    290                 295                 300                 


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
305                 310                 315                 320 


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
                325                 330                 335     


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
            340                 345                 350         


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
        355                 360                 365             


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
    370                 375                 380                 


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
385                 390                 395                 400 


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
                405                 410                 415     


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
            420                 425                 430         


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440             


<210>  162
<211>  113
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  162

Gln Ser Val Glu Ala Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Ser Ala Ala 
            20                  25                  30          


Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Phe Ile Glu Tyr Ser Lys Asn Ile Val Tyr Ala Ser Trp Ala Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Lys Val Ser Ser Thr Thr Val Asp Leu Lys Met 
65                  70                  75                  80  


Thr Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Gly 
                85                  90                  95      


Gly Gly Glu Phe Phe Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  163
<211>  29
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  163

Gln Ser Val Glu Ala Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser 
            20                  25                  


<210>  164
<211>  5
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  164

Ser Ala Ala Met Asn 
1               5   


<210>  165
<211>  14
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  165

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
1               5                   10                  


<210>  166
<211>  16
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  166

Phe Ile Glu Tyr Ser Lys Asn Ile Val Tyr Ala Ser Trp Ala Lys Gly 
1               5                   10                  15      


<210>  167
<211>  31
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  167

Arg Phe Thr Ile Ser Lys Val Ser Ser Thr Thr Val Asp Leu Lys Met 
1               5                   10                  15      


Thr Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg 
            20                  25                  30      


<210>  168
<211>  7
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  168

Gly Gly Gly Glu Phe Phe Ile 
1               5           


<210>  169
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  169

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  170
<211>  330
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  170

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  171
<211>  1329
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  171
cagtcggtgg aggcgtccgg gggtcgcctg gtcacgcctg ggacacccct gacactcacc       60

tgcaccgtct ctggattctc cctcagtagc gctgcaatga actgggtccg ccaggctcca      120

gggaaggggc tggaatggat cggatttatt gagtatagta agaatatagt ttacgcgtcc      180

tgggcgaaag gccgattcac catctccaaa gtctcgtcga ccacggtgga tctgaaaatg      240

accagtccga caaccgagga cacggccacc tatttctgtg ccaggggggg aggggaattt      300

ttcatctggg gccaaggcac cctggtcacc gtctcgagcg cctccaccaa gggcccatcg      360

gtcttccccc tggcaccctc ctccaagagc acctctgggg gcacagcggc cctgggctgc      420

ctggtcaagg actacttccc cgaaccggtg acggtgtcgt ggaactcagg cgccctgacc      480

agcggcgtgc acaccttccc ggctgtccta cagtcctcag gactctactc cctcagcagc      540

gtggtgaccg tgccctccag cagcttgggc acccagacct acatctgcaa cgtgaatcac      600

aagcccagca acaccaaggt ggacaagaaa gttgagccca aatcttgtga caaaactcac      660

acatgcccac cgtgcccagc acctgaactc ctggggggac cgtcagtctt cctcttcccc      720

ccaaaaccca aggacaccct catgatctcc cggacccctg aggtcacatg cgtggtggtg      780

gacgtgagcc acgaagaccc tgaggtcaag ttcaactggt acgtggacgg cgtggaggtg      840

cataatgcca agacaaagcc gcgggaggag cagtacgcca gcacgtaccg tgtggtcagc      900

gtcctcaccg tcctgcacca ggactggctg aatggcaagg agtacaagtg caaggtctcc      960

aacaaagccc tcccagcccc catcgagaaa accatctcca aagccaaagg gcagccccga     1020

gaaccacagg tgtacaccct gcccccatcc cgggaggaga tgaccaagaa ccaggtcagc     1080

ctgacctgcc tggtcaaagg cttctatccc agcgacatcg ccgtggagtg ggagagcaat     1140

gggcagccgg agaacaacta caagaccacg cctcccgtgc tggactccga cggctccttc     1200

ttcctctaca gcaagctcac cgtggacaag agcaggtggc agcaggggaa cgtcttctca     1260

tgctccgtga tgcatgaggc tctgcacaac cactacacgc agaagagcct ctccctgtct     1320

ccgggtaaa                                                             1329


<210>  172
<211>  339
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  172
cagtcggtgg aggcgtccgg gggtcgcctg gtcacgcctg ggacacccct gacactcacc       60

tgcaccgtct ctggattctc cctcagtagc gctgcaatga actgggtccg ccaggctcca      120

gggaaggggc tggaatggat cggatttatt gagtatagta agaatatagt ttacgcgtcc      180

tgggcgaaag gccgattcac catctccaaa gtctcgtcga ccacggtgga tctgaaaatg      240

accagtccga caaccgagga cacggccacc tatttctgtg ccaggggggg aggggaattt      300

ttcatctggg gccaaggcac cctggtcacc gtctcgagc                             339


<210>  173
<211>  87
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  173
cagtcggtgg aggcgtccgg gggtcgcctg gtcacgcctg ggacacccct gacactcacc       60

tgcaccgtct ctggattctc cctcagt                                           87


<210>  174
<211>  15
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  174
agcgctgcaa tgaac                                                        15


<210>  175
<211>  42
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  175
tgggtccgcc aggctccagg gaaggggctg gaatggatcg ga                          42


<210>  176
<211>  48
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  176
tttattgagt atagtaagaa tatagtttac gcgtcctggg cgaaaggc                    48


<210>  177
<211>  93
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  177
cgattcacca tctccaaagt ctcgtcgacc acggtggatc tgaaaatgac cagtccgaca       60

accgaggaca cggccaccta tttctgtgcc agg                                    93


<210>  178
<211>  21
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  178
gggggagggg aatttttcat c                                                 21


<210>  179
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  179
tggggccaag gcaccctggt caccgtctcg agc                                    33


<210>  180
<211>  990
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  180
gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg       60

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      240

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttgagccc      300

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      360

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      420

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      480

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacgcc      540

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      600

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc      660

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggaggag      720

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc      780

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg      840

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg      900

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg      960

cagaagagcc tctccctgtc tccgggtaaa                                       990


<210>  181
<211>  217
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  181

Ala Gln Val Leu Thr Gln Thr Pro Ser Ser Val Ser Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Asn Cys Gln Ser Ser Gln Ser Val Tyr Ser Asn 
            20                  25                  30          


Asn Arg Leu Ser Tyr Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Glu Ala Ser Ser Leu Ala Tyr Gly Val Pro Ser Arg Phe 
    50                  55                  60                  


Lys Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Asp Leu 
65                  70                  75                  80  


Glu Cys Asp Asp Ala Ala Thr Tyr Tyr Cys Ala Gly Ala Tyr Ser Asn 
                85                  90                  95      


Ser Ile Tyr Ser Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg Thr 
            100                 105                 110         


Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
        115                 120                 125             


Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
    130                 135                 140                 


Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
145                 150                 155                 160 


Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
                165                 170                 175     


Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
            180                 185                 190         


Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
        195                 200                 205             


Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215         


<210>  182
<211>  111
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  182

Ala Gln Val Leu Thr Gln Thr Pro Ser Ser Val Ser Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Asn Cys Gln Ser Ser Gln Ser Val Tyr Ser Asn 
            20                  25                  30          


Asn Arg Leu Ser Tyr Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Glu Ala Ser Ser Leu Ala Tyr Gly Val Pro Ser Arg Phe 
    50                  55                  60                  


Lys Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Asp Leu 
65                  70                  75                  80  


Glu Cys Asp Asp Ala Ala Thr Tyr Tyr Cys Ala Gly Ala Tyr Ser Asn 
                85                  90                  95      


Ser Ile Tyr Ser Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg 
            100                 105                 110     


<210>  183
<211>  23
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  183

Ala Gln Val Leu Thr Gln Thr Pro Ser Ser Val Ser Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Asn Cys 
            20              


<210>  184
<211>  13
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  184

Gln Ser Ser Gln Ser Val Tyr Ser Asn Asn Arg Leu Ser 
1               5                   10              


<210>  185
<211>  15
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  185

Tyr Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  186
<211>  7
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  186

Glu Ala Ser Ser Leu Ala Tyr 
1               5           


<210>  187
<211>  32
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  187

Gly Val Pro Ser Arg Phe Lys Gly Ser Gly Ser Gly Thr Gln Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Asp Leu Glu Cys Asp Asp Ala Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  188
<211>  10
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  188

Ala Gly Ala Tyr Ser Asn Ser Ile Tyr Ser 
1               5                   10  


<210>  189
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  189

Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg 
1               5                   10      


<210>  190
<211>  106
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  190

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105     


<210>  191
<211>  651
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  191
gcgcaagtgc tgacccagac tccatcgtcc gtgtctgcag ctgtgggagg cacagtcacc       60

atcaattgcc agtccagtca gagtgtttat agtaacaacc ggttatcgta ctatcagcag      120

aaaccagggc agcctcccaa gctcctgatc tacgaagcat ccagtctggc atatggggtc      180

ccatcgcggt tcaaaggcag tggatctggg acacagttca ctctcaccat cagcgacctg      240

gagtgtgacg atgccgccac ttattactgt gcaggtgcct atagtaatag tatttatagt      300

ttcggcggag ggaccgaggt ggtggtcaaa cgtacggtag cggccccatc tgtcttcatc      360

ttcccgccat ctgatgagca gttgaaatct ggaactgcct ctgttgtgtg cctgctgaat      420

aacttctatc ccagagaggc caaagtacag tggaaggtgg ataacgccct ccaatcgggt      480

aactcccagg agagtgtcac agagcaggac agcaaggaca gcacctacag cctcagcagc      540

accctgacgc tgagcaaagc agactacgag aaacacaaag tctacgcctg cgaagtcacc      600

catcagggcc tgagctcgcc cgtcacaaag agcttcaaca ggggagagtg t               651


<210>  192
<211>  333
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  192
gcgcaagtgc tgacccagac tccatcgtcc gtgtctgcag ctgtgggagg cacagtcacc       60

atcaattgcc agtccagtca gagtgtttat agtaacaacc ggttatcgta ctatcagcag      120

aaaccagggc agcctcccaa gctcctgatc tacgaagcat ccagtctggc atatggggtc      180

ccatcgcggt tcaaaggcag tggatctggg acacagttca ctctcaccat cagcgacctg      240

gagtgtgacg atgccgccac ttattactgt gcaggtgcct atagtaatag tatttatagt      300

ttcggcggag ggaccgaggt ggtggtcaaa cgt                                   333


<210>  193
<211>  69
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  193
gcgcaagtgc tgacccagac tccatcgtcc gtgtctgcag ctgtgggagg cacagtcacc       60

atcaattgc                                                               69


<210>  194
<211>  39
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  194
cagtccagtc agagtgttta tagtaacaac cggttatcg                              39


<210>  195
<211>  45
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  195
tactatcagc agaaaccagg gcagcctccc aagctcctga tctac                       45


<210>  196
<211>  21
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  196
gaagcatcca gtctggcata t                                                 21


<210>  197
<211>  96
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  197
ggggtcccat cgcggttcaa aggcagtgga tctgggacac agttcactct caccatcagc       60

gacctggagt gtgacgatgc cgccacttat tactgt                                 96


<210>  198
<211>  30
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  198
gcaggtgcct atagtaatag tatttatagt                                        30


<210>  199
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  199
ttcggcggag ggaccgaggt ggtggtcaaa cgt                                    33


<210>  200
<211>  318
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  200
acggtagcgg ccccatctgt cttcatcttc ccgccatctg atgagcagtt gaaatctgga       60

actgcctctg ttgtgtgcct gctgaataac ttctatccca gagaggccaa agtacagtgg      120

aaggtggata acgccctcca atcgggtaac tcccaggaga gtgtcacaga gcaggacagc      180

aaggacagca cctacagcct cagcagcacc ctgacgctga gcaaagcaga ctacgagaaa      240

cacaaagtct acgcctgcga agtcacccat cagggcctga gctcgcccgt cacaaagagc      300

ttcaacaggg gagagtgt                                                    318


<210>  201
<211>  443
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  201

Gln Ser Val Glu Ala Ser Gly Gly His Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Ser Ala Ala 
            20                  25                  30          


Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Ser Val Asp Glu Arg Gln Asn Lys Tyr Tyr Ala Ser Trp Ala Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Arg Thr Ser Ser Thr Thr Val Asn Leu Lys Met 
65                  70                  75                  80  


Thr Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Gly 
                85                  90                  95      


Gly Gly Glu Phe Phe Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
        115                 120                 125             


Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
    130                 135                 140                 


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
145                 150                 155                 160 


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
                165                 170                 175     


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
            180                 185                 190         


Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
        195                 200                 205             


Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
    210                 215                 220                 


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
225                 230                 235                 240 


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
                245                 250                 255     


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
            260                 265                 270         


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
        275                 280                 285             


Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
    290                 295                 300                 


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
305                 310                 315                 320 


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
                325                 330                 335     


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
            340                 345                 350         


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
        355                 360                 365             


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
    370                 375                 380                 


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
385                 390                 395                 400 


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
                405                 410                 415     


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
            420                 425                 430         


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440             


<210>  202
<211>  113
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  202

Gln Ser Val Glu Ala Ser Gly Gly His Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Ser Ala Ala 
            20                  25                  30          


Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Ser Val Asp Glu Arg Gln Asn Lys Tyr Tyr Ala Ser Trp Ala Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Arg Thr Ser Ser Thr Thr Val Asn Leu Lys Met 
65                  70                  75                  80  


Thr Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Gly 
                85                  90                  95      


Gly Gly Glu Phe Phe Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  203
<211>  29
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  203

Gln Ser Val Glu Ala Ser Gly Gly His Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser 
            20                  25                  


<210>  204
<211>  5
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  204

Ser Ala Ala Met Asn 
1               5   


<210>  205
<211>  14
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  205

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
1               5                   10                  


<210>  206
<211>  16
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  206

Ser Val Asp Glu Arg Gln Asn Lys Tyr Tyr Ala Ser Trp Ala Lys Gly 
1               5                   10                  15      


<210>  207
<211>  31
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  207

Arg Phe Thr Ile Ser Arg Thr Ser Ser Thr Thr Val Asn Leu Lys Met 
1               5                   10                  15      


Thr Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg 
            20                  25                  30      


<210>  208
<211>  7
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  208

Gly Gly Gly Glu Phe Phe Ile 
1               5           


<210>  209
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  209

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  210
<211>  330
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  210

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  211
<211>  1329
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  211
cagtcggtgg aggcgtccgg gggtcaccta gtcacgcctg ggacacccct gacactcacc       60

tgcaccgtct ctggattctc cctcagtagc gctgcaatga actgggtccg ccaggctcca      120

gggaaggggc tggaatggat cggatcggtt gatgagcgtc agaataaata ttacgcgtcc      180

tgggcgaaag gccgattcac catctccaga acctcgtcga ccacggtgaa tctgaaaatg      240

accagtccga caaccgagga cacggccacc tatttctgtg ccagaggggg aggggaattt      300

ttcatctggg gccagggcac cctcgtcacc gtctcgagcg cctccaccaa gggcccatcg      360

gtcttccccc tggcaccctc ctccaagagc acctctgggg gcacagcggc cctgggctgc      420

ctggtcaagg actacttccc cgaaccggtg acggtgtcgt ggaactcagg cgccctgacc      480

agcggcgtgc acaccttccc ggctgtccta cagtcctcag gactctactc cctcagcagc      540

gtggtgaccg tgccctccag cagcttgggc acccagacct acatctgcaa cgtgaatcac      600

aagcccagca acaccaaggt ggacaagaaa gttgagccca aatcttgtga caaaactcac      660

acatgcccac cgtgcccagc acctgaactc ctggggggac cgtcagtctt cctcttcccc      720

ccaaaaccca aggacaccct catgatctcc cggacccctg aggtcacatg cgtggtggtg      780

gacgtgagcc acgaagaccc tgaggtcaag ttcaactggt acgtggacgg cgtggaggtg      840

cataatgcca agacaaagcc gcgggaggag cagtacgcca gcacgtaccg tgtggtcagc      900

gtcctcaccg tcctgcacca ggactggctg aatggcaagg agtacaagtg caaggtctcc      960

aacaaagccc tcccagcccc catcgagaaa accatctcca aagccaaagg gcagccccga     1020

gaaccacagg tgtacaccct gcccccatcc cgggaggaga tgaccaagaa ccaggtcagc     1080

ctgacctgcc tggtcaaagg cttctatccc agcgacatcg ccgtggagtg ggagagcaat     1140

gggcagccgg agaacaacta caagaccacg cctcccgtgc tggactccga cggctccttc     1200

ttcctctaca gcaagctcac cgtggacaag agcaggtggc agcaggggaa cgtcttctca     1260

tgctccgtga tgcatgaggc tctgcacaac cactacacgc agaagagcct ctccctgtct     1320

ccgggtaaa                                                             1329


<210>  212
<211>  339
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  212
cagtcggtgg aggcgtccgg gggtcaccta gtcacgcctg ggacacccct gacactcacc       60

tgcaccgtct ctggattctc cctcagtagc gctgcaatga actgggtccg ccaggctcca      120

gggaaggggc tggaatggat cggatcggtt gatgagcgtc agaataaata ttacgcgtcc      180

tgggcgaaag gccgattcac catctccaga acctcgtcga ccacggtgaa tctgaaaatg      240

accagtccga caaccgagga cacggccacc tatttctgtg ccagaggggg aggggaattt      300

ttcatctggg gccagggcac cctcgtcacc gtctcgagc                             339


<210>  213
<211>  87
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  213
cagtcggtgg aggcgtccgg gggtcaccta gtcacgcctg ggacacccct gacactcacc       60

tgcaccgtct ctggattctc cctcagt                                           87


<210>  214
<211>  15
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  214
agcgctgcaa tgaac                                                        15


<210>  215
<211>  42
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  215
tgggtccgcc aggctccagg gaaggggctg gaatggatcg ga                          42


<210>  216
<211>  48
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  216
tcggttgatg agcgtcagaa taaatattac gcgtcctggg cgaaaggc                    48


<210>  217
<211>  93
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  217
cgattcacca tctccagaac ctcgtcgacc acggtgaatc tgaaaatgac cagtccgaca       60

accgaggaca cggccaccta tttctgtgcc aga                                    93


<210>  218
<211>  21
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  218
gggggagggg aatttttcat c                                                 21


<210>  219
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  219
tggggccagg gcaccctcgt caccgtctcg agc                                    33


<210>  220
<211>  990
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  220
gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg       60

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      240

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttgagccc      300

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      360

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      420

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      480

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacgcc      540

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      600

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc      660

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggaggag      720

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc      780

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg      840

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg      900

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg      960

cagaagagcc tctccctgtc tccgggtaaa                                       990


<210>  221
<211>  217
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  221

Ala Gln Val Leu Thr Gln Thr Pro Ser Ser Val Ser Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Asn Cys Gln Ser Ser Gln Ser Val Tyr Ser Asn 
            20                  25                  30          


Asn Arg Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Asn Leu 
        35                  40                  45              


Leu Ile Tyr Glu Ala Ser Ser Leu Ala Ser Gly Val Pro Ser Arg Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Asp Leu 
65                  70                  75                  80  


Glu Cys Asp Asp Ala Ala Thr Tyr Tyr Cys Ala Gly Ala Tyr Asn Thr 
                85                  90                  95      


Gly Ile Tyr Gly Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg Thr 
            100                 105                 110         


Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
        115                 120                 125             


Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
    130                 135                 140                 


Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
145                 150                 155                 160 


Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
                165                 170                 175     


Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
            180                 185                 190         


Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
        195                 200                 205             


Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215         


<210>  222
<211>  111
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  222

Ala Gln Val Leu Thr Gln Thr Pro Ser Ser Val Ser Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Asn Cys Gln Ser Ser Gln Ser Val Tyr Ser Asn 
            20                  25                  30          


Asn Arg Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Asn Leu 
        35                  40                  45              


Leu Ile Tyr Glu Ala Ser Ser Leu Ala Ser Gly Val Pro Ser Arg Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Asp Leu 
65                  70                  75                  80  


Glu Cys Asp Asp Ala Ala Thr Tyr Tyr Cys Ala Gly Ala Tyr Asn Thr 
                85                  90                  95      


Gly Ile Tyr Gly Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg 
            100                 105                 110     


<210>  223
<211>  23
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  223

Ala Gln Val Leu Thr Gln Thr Pro Ser Ser Val Ser Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Asn Cys 
            20              


<210>  224
<211>  13
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  224

Gln Ser Ser Gln Ser Val Tyr Ser Asn Asn Arg Leu Ser 
1               5                   10              


<210>  225
<211>  15
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  225

Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Asn Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  226
<211>  7
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  226

Glu Ala Ser Ser Leu Ala Ser 
1               5           


<210>  227
<211>  32
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  227

Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Gln Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Asp Leu Glu Cys Asp Asp Ala Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  228
<211>  10
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  228

Ala Gly Ala Tyr Asn Thr Gly Ile Tyr Gly 
1               5                   10  


<210>  229
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  229

Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg 
1               5                   10      


<210>  230
<211>  106
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  230

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105     


<210>  231
<211>  651
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  231
gcgcaagtgc tgacccagac tccatcgtcc gtgtctgcag ctgtgggagg cacagtcacc       60

atcaattgcc agtccagtca gagtgtttat agtaacaacc gcttatcctg gtatcagcag      120

aaaccagggc agcctcccaa tctcctgatc tacgaagcat ccagtctggc atctggggtc      180

ccatcgcggt tcagcggcag tggatctggg acacagttca ctctcaccat cagcgacctg      240

gagtgtgacg atgccgccac ttattactgt gcaggcgctt ataatactgg gatttatggt      300

ttcggcggag ggaccgaggt ggtggtcaaa cgtacggtag cggccccatc tgtcttcatc      360

ttcccgccat ctgatgagca gttgaaatct ggaactgcct ctgttgtgtg cctgctgaat      420

aacttctatc ccagagaggc caaagtacag tggaaggtgg ataacgccct ccaatcgggt      480

aactcccagg agagtgtcac agagcaggac agcaaggaca gcacctacag cctcagcagc      540

accctgacgc tgagcaaagc agactacgag aaacacaaag tctacgcctg cgaagtcacc      600

catcagggcc tgagctcgcc cgtcacaaag agcttcaaca ggggagagtg t               651


<210>  232
<211>  333
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  232
gcgcaagtgc tgacccagac tccatcgtcc gtgtctgcag ctgtgggagg cacagtcacc       60

atcaattgcc agtccagtca gagtgtttat agtaacaacc gcttatcctg gtatcagcag      120

aaaccagggc agcctcccaa tctcctgatc tacgaagcat ccagtctggc atctggggtc      180

ccatcgcggt tcagcggcag tggatctggg acacagttca ctctcaccat cagcgacctg      240

gagtgtgacg atgccgccac ttattactgt gcaggcgctt ataatactgg gatttatggt      300

ttcggcggag ggaccgaggt ggtggtcaaa cgt                                   333


<210>  233
<211>  69
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  233
gcgcaagtgc tgacccagac tccatcgtcc gtgtctgcag ctgtgggagg cacagtcacc       60

atcaattgc                                                               69


<210>  234
<211>  39
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  234
cagtccagtc agagtgttta tagtaacaac cgcttatcc                              39


<210>  235
<211>  45
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  235
tggtatcagc agaaaccagg gcagcctccc aatctcctga tctac                       45


<210>  236
<211>  21
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  236
gaagcatcca gtctggcatc t                                                 21


<210>  237
<211>  96
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  237
ggggtcccat cgcggttcag cggcagtgga tctgggacac agttcactct caccatcagc       60

gacctggagt gtgacgatgc cgccacttat tactgt                                 96


<210>  238
<211>  30
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  238
gcaggcgctt ataatactgg gatttatggt                                        30


<210>  239
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  239
ttcggcggag ggaccgaggt ggtggtcaaa cgt                                    33


<210>  240
<211>  318
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  240
acggtagcgg ccccatctgt cttcatcttc ccgccatctg atgagcagtt gaaatctgga       60

actgcctctg ttgtgtgcct gctgaataac ttctatccca gagaggccaa agtacagtgg      120

aaggtggata acgccctcca atcgggtaac tcccaggaga gtgtcacaga gcaggacagc      180

aaggacagca cctacagcct cagcagcacc ctgacgctga gcaaagcaga ctacgagaaa      240

cacaaagtct acgcctgcga agtcacccat cagggcctga gctcgcccgt cacaaagagc      300

ttcaacaggg gagagtgt                                                    318


<210>  241
<211>  443
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  241

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Ser Ala Ala 
            20                  25                  30          


Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Ile Ile Asp Asp Ser Gly Asn Thr Tyr Tyr Ala Ser Trp Ala Lys Ala 
    50                  55                  60                  


Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr Val Asp Leu Lys Met 
65                  70                  75                  80  


Thr Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Gly 
                85                  90                  95      


Gly Gly Glu Phe Phe Ile Trp Gly Pro Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
        115                 120                 125             


Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
    130                 135                 140                 


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
145                 150                 155                 160 


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
                165                 170                 175     


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
            180                 185                 190         


Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
        195                 200                 205             


Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
    210                 215                 220                 


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
225                 230                 235                 240 


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
                245                 250                 255     


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
            260                 265                 270         


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
        275                 280                 285             


Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
    290                 295                 300                 


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
305                 310                 315                 320 


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
                325                 330                 335     


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
            340                 345                 350         


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
        355                 360                 365             


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
    370                 375                 380                 


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
385                 390                 395                 400 


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
                405                 410                 415     


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
            420                 425                 430         


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440             


<210>  242
<211>  113
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  242

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Ser Ala Ala 
            20                  25                  30          


Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Ile Ile Asp Asp Ser Gly Asn Thr Tyr Tyr Ala Ser Trp Ala Lys Ala 
    50                  55                  60                  


Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr Val Asp Leu Lys Met 
65                  70                  75                  80  


Thr Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Gly 
                85                  90                  95      


Gly Gly Glu Phe Phe Ile Trp Gly Pro Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  243
<211>  29
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  243

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser 
            20                  25                  


<210>  244
<211>  5
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  244

Ser Ala Ala Met Ser 
1               5   


<210>  245
<211>  14
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  245

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
1               5                   10                  


<210>  246
<211>  16
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  246

Ile Ile Asp Asp Ser Gly Asn Thr Tyr Tyr Ala Ser Trp Ala Lys Ala 
1               5                   10                  15      


<210>  247
<211>  31
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  247

Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr Val Asp Leu Lys Met 
1               5                   10                  15      


Thr Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg 
            20                  25                  30      


<210>  248
<211>  7
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  248

Gly Gly Gly Glu Phe Phe Ile 
1               5           


<210>  249
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  249

Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  250
<211>  330
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  250

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  251
<211>  1329
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  251
cagtcggtgg aggagtccgg gggtcgcctg gtcacgcctg ggacacccct gacactcacc       60

tgcaccgtct ctggattctc cctcagtagc gctgcaatga gctgggtccg ccaggctcca      120

gggaaggggc tggaatggat cggaattatt gatgatagtg gtaacacata ctacgcgtcc      180

tgggcgaaag cccgattcac catctccaaa acctcgtcga ccacggtgga tctgaaaatg      240

accagtccga caaccgagga cacggccacc tatttctgtg ccagaggggg aggggagttt      300

ttcatctggg gcccgggcac cctcgtcacc gtctcgagcg cctccaccaa gggcccatcg      360

gtcttccccc tggcaccctc ctccaagagc acctctgggg gcacagcggc cctgggctgc      420

ctggtcaagg actacttccc cgaaccggtg acggtgtcgt ggaactcagg cgccctgacc      480

agcggcgtgc acaccttccc ggctgtccta cagtcctcag gactctactc cctcagcagc      540

gtggtgaccg tgccctccag cagcttgggc acccagacct acatctgcaa cgtgaatcac      600

aagcccagca acaccaaggt ggacaagaaa gttgagccca aatcttgtga caaaactcac      660

acatgcccac cgtgcccagc acctgaactc ctggggggac cgtcagtctt cctcttcccc      720

ccaaaaccca aggacaccct catgatctcc cggacccctg aggtcacatg cgtggtggtg      780

gacgtgagcc acgaagaccc tgaggtcaag ttcaactggt acgtggacgg cgtggaggtg      840

cataatgcca agacaaagcc gcgggaggag cagtacgcca gcacgtaccg tgtggtcagc      900

gtcctcaccg tcctgcacca ggactggctg aatggcaagg agtacaagtg caaggtctcc      960

aacaaagccc tcccagcccc catcgagaaa accatctcca aagccaaagg gcagccccga     1020

gaaccacagg tgtacaccct gcccccatcc cgggaggaga tgaccaagaa ccaggtcagc     1080

ctgacctgcc tggtcaaagg cttctatccc agcgacatcg ccgtggagtg ggagagcaat     1140

gggcagccgg agaacaacta caagaccacg cctcccgtgc tggactccga cggctccttc     1200

ttcctctaca gcaagctcac cgtggacaag agcaggtggc agcaggggaa cgtcttctca     1260

tgctccgtga tgcatgaggc tctgcacaac cactacacgc agaagagcct ctccctgtct     1320

ccgggtaaa                                                             1329


<210>  252
<211>  339
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  252
cagtcggtgg aggagtccgg gggtcgcctg gtcacgcctg ggacacccct gacactcacc       60

tgcaccgtct ctggattctc cctcagtagc gctgcaatga gctgggtccg ccaggctcca      120

gggaaggggc tggaatggat cggaattatt gatgatagtg gtaacacata ctacgcgtcc      180

tgggcgaaag cccgattcac catctccaaa acctcgtcga ccacggtgga tctgaaaatg      240

accagtccga caaccgagga cacggccacc tatttctgtg ccagaggggg aggggagttt      300

ttcatctggg gcccgggcac cctcgtcacc gtctcgagc                             339


<210>  253
<211>  87
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  253
cagtcggtgg aggagtccgg gggtcgcctg gtcacgcctg ggacacccct gacactcacc       60

tgcaccgtct ctggattctc cctcagt                                           87


<210>  254
<211>  15
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  254
agcgctgcaa tgagc                                                        15


<210>  255
<211>  42
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  255
tgggtccgcc aggctccagg gaaggggctg gaatggatcg ga                          42


<210>  256
<211>  48
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  256
attattgatg atagtggtaa cacatactac gcgtcctggg cgaaagcc                    48


<210>  257
<211>  93
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  257
cgattcacca tctccaaaac ctcgtcgacc acggtggatc tgaaaatgac cagtccgaca       60

accgaggaca cggccaccta tttctgtgcc aga                                    93


<210>  258
<211>  21
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  258
gggggagggg agtttttcat c                                                 21


<210>  259
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  259
tggggcccgg gcaccctcgt caccgtctcg agc                                    33


<210>  260
<211>  990
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  260
gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg       60

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      240

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttgagccc      300

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      360

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      420

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      480

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacgcc      540

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      600

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc      660

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggaggag      720

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc      780

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg      840

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg      900

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg      960

cagaagagcc tctccctgtc tccgggtaaa                                       990


<210>  261
<211>  217
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  261

Asp Pro Val Leu Thr Gln Thr Pro Ser Ser Val Ser Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Asn Cys Gln Ser Ser Gln Ser Val Tyr Asn Asn 
            20                  25                  30          


Lys Trp Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Phe 
        35                  40                  45              


Leu Ile Tyr Gln Ala Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe 
    50                  55                  60                  


Lys Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Asp Leu 
65                  70                  75                  80  


Glu Cys Asp Asp Gly Ala Thr Tyr Tyr Cys Ala Gly Gly Tyr Arg Gly 
                85                  90                  95      


Asn Val Cys Gly Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg Thr 
            100                 105                 110         


Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
        115                 120                 125             


Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
    130                 135                 140                 


Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
145                 150                 155                 160 


Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
                165                 170                 175     


Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
            180                 185                 190         


Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
        195                 200                 205             


Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215         


<210>  262
<211>  111
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  262

Asp Pro Val Leu Thr Gln Thr Pro Ser Ser Val Ser Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Asn Cys Gln Ser Ser Gln Ser Val Tyr Asn Asn 
            20                  25                  30          


Lys Trp Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Phe 
        35                  40                  45              


Leu Ile Tyr Gln Ala Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe 
    50                  55                  60                  


Lys Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Asp Leu 
65                  70                  75                  80  


Glu Cys Asp Asp Gly Ala Thr Tyr Tyr Cys Ala Gly Gly Tyr Arg Gly 
                85                  90                  95      


Asn Val Cys Gly Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg 
            100                 105                 110     


<210>  263
<211>  23
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  263

Asp Pro Val Leu Thr Gln Thr Pro Ser Ser Val Ser Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Asn Cys 
            20              


<210>  264
<211>  13
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  264

Gln Ser Ser Gln Ser Val Tyr Asn Asn Lys Trp Leu Ser 
1               5                   10              


<210>  265
<211>  15
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  265

Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Phe Leu Ile Tyr 
1               5                   10                  15  


<210>  266
<211>  7
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  266

Gln Ala Ser Asn Leu Ala Ser 
1               5           


<210>  267
<211>  32
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  267

Gly Val Pro Ser Arg Phe Lys Gly Ser Gly Ser Gly Thr Gln Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Asp Leu Glu Cys Asp Asp Gly Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  268
<211>  10
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  268

Ala Gly Gly Tyr Arg Gly Asn Val Cys Gly 
1               5                   10  


<210>  269
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  269

Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg 
1               5                   10      


<210>  270
<211>  106
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  270

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105     


<210>  271
<211>  651
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  271
gaccctgtgc tgacccagac tccatcgtcc gtgtctgcag ctgtgggagg cacagtcacc       60

atcaattgcc agtccagtca gagtgtttat aataacaagt ggttatcctg gtatcagcag      120

aaaccaggac agtctcccaa gttcctgatt taccaggcat ccaatttggc atctggggtc      180

ccatcgcggt tcaaaggcag tggatctggg acacagttca ctctcaccat cagcgacctg      240

gagtgtgacg atggcgccac ttattactgt gcaggcggct accgtggtaa tgtttgtggt      300

ttcggcggag ggaccgaggt ggtggtcaaa cgtacggtag cggccccatc tgtcttcatc      360

ttcccgccat ctgatgagca gttgaaatct ggaactgcct ctgttgtgtg cctgctgaat      420

aacttctatc ccagagaggc caaagtacag tggaaggtgg ataacgccct ccaatcgggt      480

aactcccagg agagtgtcac agagcaggac agcaaggaca gcacctacag cctcagcagc      540

accctgacgc tgagcaaagc agactacgag aaacacaaag tctacgcctg cgaagtcacc      600

catcagggcc tgagctcgcc cgtcacaaag agcttcaaca ggggagagtg t               651


<210>  272
<211>  333
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  272
gaccctgtgc tgacccagac tccatcgtcc gtgtctgcag ctgtgggagg cacagtcacc       60

atcaattgcc agtccagtca gagtgtttat aataacaagt ggttatcctg gtatcagcag      120

aaaccaggac agtctcccaa gttcctgatt taccaggcat ccaatttggc atctggggtc      180

ccatcgcggt tcaaaggcag tggatctggg acacagttca ctctcaccat cagcgacctg      240

gagtgtgacg atggcgccac ttattactgt gcaggcggct accgtggtaa tgtttgtggt      300

ttcggcggag ggaccgaggt ggtggtcaaa cgt                                   333


<210>  273
<211>  69
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  273
gaccctgtgc tgacccagac tccatcgtcc gtgtctgcag ctgtgggagg cacagtcacc       60

atcaattgc                                                               69


<210>  274
<211>  39
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  274
cagtccagtc agagtgttta taataacaag tggttatcc                              39


<210>  275
<211>  45
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  275
tggtatcagc agaaaccagg acagtctccc aagttcctga tttac                       45


<210>  276
<211>  21
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  276
caggcatcca atttggcatc t                                                 21


<210>  277
<211>  96
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  277
ggggtcccat cgcggttcaa aggcagtgga tctgggacac agttcactct caccatcagc       60

gacctggagt gtgacgatgg cgccacttat tactgt                                 96


<210>  278
<211>  30
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  278
gcaggcggct accgtggtaa tgtttgtggt                                        30


<210>  279
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  279
ttcggcggag ggaccgaggt ggtggtcaaa cgt                                    33


<210>  280
<211>  318
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  280
acggtagcgg ccccatctgt cttcatcttc ccgccatctg atgagcagtt gaaatctgga       60

actgcctctg ttgtgtgcct gctgaataac ttctatccca gagaggccaa agtacagtgg      120

aaggtggata acgccctcca atcgggtaac tcccaggaga gtgtcacaga gcaggacagc      180

aaggacagca cctacagcct cagcagcacc ctgacgctga gcaaagcaga ctacgagaaa      240

cacaaagtct acgcctgcga agtcacccat cagggcctga gctcgcccgt cacaaagagc      300

ttcaacaggg gagagtgt                                                    318


<210>  281
<211>  443
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  281

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Ser Ala Ala 
            20                  25                  30          


Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Ile Phe Asp Pro Tyr Ser Ser Thr Tyr Tyr Ala Ser Trp Ala Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr Val Asp Leu Lys Met 
65                  70                  75                  80  


Thr Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Gly 
                85                  90                  95      


Gly Gly Glu Phe Phe Ile Trp Gly Pro Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
        115                 120                 125             


Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
    130                 135                 140                 


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
145                 150                 155                 160 


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
                165                 170                 175     


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
            180                 185                 190         


Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
        195                 200                 205             


Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
    210                 215                 220                 


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
225                 230                 235                 240 


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
                245                 250                 255     


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
            260                 265                 270         


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
        275                 280                 285             


Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
    290                 295                 300                 


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
305                 310                 315                 320 


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
                325                 330                 335     


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
            340                 345                 350         


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
        355                 360                 365             


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
    370                 375                 380                 


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
385                 390                 395                 400 


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
                405                 410                 415     


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
            420                 425                 430         


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440             


<210>  282
<211>  113
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  282

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Ser Ala Ala 
            20                  25                  30          


Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Ile Phe Asp Pro Tyr Ser Ser Thr Tyr Tyr Ala Ser Trp Ala Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr Val Asp Leu Lys Met 
65                  70                  75                  80  


Thr Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Gly 
                85                  90                  95      


Gly Gly Glu Phe Phe Ile Trp Gly Pro Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  283
<211>  29
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  283

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser 
            20                  25                  


<210>  284
<211>  5
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  284

Ser Ala Ala Met Asn 
1               5   


<210>  285
<211>  14
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  285

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
1               5                   10                  


<210>  286
<211>  16
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  286

Ile Phe Asp Pro Tyr Ser Ser Thr Tyr Tyr Ala Ser Trp Ala Lys Gly 
1               5                   10                  15      


<210>  287
<211>  31
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  287

Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr Val Asp Leu Lys Met 
1               5                   10                  15      


Thr Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg 
            20                  25                  30      


<210>  288
<211>  7
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  288

Gly Gly Gly Glu Phe Phe Ile 
1               5           


<210>  289
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  289

Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  290
<211>  330
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  290

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  291
<211>  1329
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  291
cagtcagtgg aggagtccgg gggtcgcctg gtcacgcctg ggacacccct aacactcacc       60

tgcaccgtct ctggattctc cctcagtagc gctgcaatga actgggtccg ccaggctcca      120

gggaaggggc tggaatggat cggtattttt gatccttata gtagtacata ctacgcgtcc      180

tgggcgaaag gccgattcac catctccaaa acctcgtcga ccacggtgga tctgaaaatg      240

accagtccga caaccgagga cacggccacc tatttctgtg ccagaggggg aggggaattt      300

ttcatctggg gcccaggcac cctcgtcacc gtctcgagcg cctccaccaa gggcccatcg      360

gtcttccccc tggcaccctc ctccaagagc acctctgggg gcacagcggc cctgggctgc      420

ctggtcaagg actacttccc cgaaccggtg acggtgtcgt ggaactcagg cgccctgacc      480

agcggcgtgc acaccttccc ggctgtccta cagtcctcag gactctactc cctcagcagc      540

gtggtgaccg tgccctccag cagcttgggc acccagacct acatctgcaa cgtgaatcac      600

aagcccagca acaccaaggt ggacaagaaa gttgagccca aatcttgtga caaaactcac      660

acatgcccac cgtgcccagc acctgaactc ctggggggac cgtcagtctt cctcttcccc      720

ccaaaaccca aggacaccct catgatctcc cggacccctg aggtcacatg cgtggtggtg      780

gacgtgagcc acgaagaccc tgaggtcaag ttcaactggt acgtggacgg cgtggaggtg      840

cataatgcca agacaaagcc gcgggaggag cagtacgcca gcacgtaccg tgtggtcagc      900

gtcctcaccg tcctgcacca ggactggctg aatggcaagg agtacaagtg caaggtctcc      960

aacaaagccc tcccagcccc catcgagaaa accatctcca aagccaaagg gcagccccga     1020

gaaccacagg tgtacaccct gcccccatcc cgggaggaga tgaccaagaa ccaggtcagc     1080

ctgacctgcc tggtcaaagg cttctatccc agcgacatcg ccgtggagtg ggagagcaat     1140

gggcagccgg agaacaacta caagaccacg cctcccgtgc tggactccga cggctccttc     1200

ttcctctaca gcaagctcac cgtggacaag agcaggtggc agcaggggaa cgtcttctca     1260

tgctccgtga tgcatgaggc tctgcacaac cactacacgc agaagagcct ctccctgtct     1320

ccgggtaaa                                                             1329


<210>  292
<211>  339
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  292
cagtcagtgg aggagtccgg gggtcgcctg gtcacgcctg ggacacccct aacactcacc       60

tgcaccgtct ctggattctc cctcagtagc gctgcaatga actgggtccg ccaggctcca      120

gggaaggggc tggaatggat cggtattttt gatccttata gtagtacata ctacgcgtcc      180

tgggcgaaag gccgattcac catctccaaa acctcgtcga ccacggtgga tctgaaaatg      240

accagtccga caaccgagga cacggccacc tatttctgtg ccagaggggg aggggaattt      300

ttcatctggg gcccaggcac cctcgtcacc gtctcgagc                             339


<210>  293
<211>  87
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  293
cagtcagtgg aggagtccgg gggtcgcctg gtcacgcctg ggacacccct aacactcacc       60

tgcaccgtct ctggattctc cctcagt                                           87


<210>  294
<211>  15
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  294
agcgctgcaa tgaac                                                        15


<210>  295
<211>  42
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  295
tgggtccgcc aggctccagg gaaggggctg gaatggatcg gt                          42


<210>  296
<211>  48
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  296
atttttgatc cttatagtag tacatactac gcgtcctggg cgaaaggc                    48


<210>  297
<211>  93
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  297
cgattcacca tctccaaaac ctcgtcgacc acggtggatc tgaaaatgac cagtccgaca       60

accgaggaca cggccaccta tttctgtgcc aga                                    93


<210>  298
<211>  21
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  298
gggggagggg aatttttcat c                                                 21


<210>  299
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  299
tggggcccag gcaccctcgt caccgtctcg agc                                    33


<210>  300
<211>  990
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  300
gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg       60

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      240

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttgagccc      300

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      360

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      420

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      480

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacgcc      540

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      600

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc      660

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggaggag      720

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc      780

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg      840

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg      900

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg      960

cagaagagcc tctccctgtc tccgggtaaa                                       990


<210>  301
<211>  217
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  301

Ala Gln Val Leu Thr Gln Thr Pro Ser Ser Val Ser Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Asn Cys Gln Ser Ser Gln Ser Val Tyr Lys Asn 
            20                  25                  30          


Lys Tyr Leu Ser Trp Tyr Gln Gln Lys Val Gly Gln Pro Pro Lys Phe 
        35                  40                  45              


Leu Ile Tyr Gln Ala Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe 
    50                  55                  60                  


Lys Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Asp Leu 
65                  70                  75                  80  


Glu Cys Asp Asp Ala Ala Thr Tyr Tyr Cys Ala Gly Gly Tyr Ser Gly 
                85                  90                  95      


Asn Met Val Asp Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg Thr 
            100                 105                 110         


Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
        115                 120                 125             


Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
    130                 135                 140                 


Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
145                 150                 155                 160 


Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
                165                 170                 175     


Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
            180                 185                 190         


Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
        195                 200                 205             


Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215         


<210>  302
<211>  111
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  302

Ala Gln Val Leu Thr Gln Thr Pro Ser Ser Val Ser Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Asn Cys Gln Ser Ser Gln Ser Val Tyr Lys Asn 
            20                  25                  30          


Lys Tyr Leu Ser Trp Tyr Gln Gln Lys Val Gly Gln Pro Pro Lys Phe 
        35                  40                  45              


Leu Ile Tyr Gln Ala Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe 
    50                  55                  60                  


Lys Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Asp Leu 
65                  70                  75                  80  


Glu Cys Asp Asp Ala Ala Thr Tyr Tyr Cys Ala Gly Gly Tyr Ser Gly 
                85                  90                  95      


Asn Met Val Asp Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg 
            100                 105                 110     


<210>  303
<211>  23
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  303

Ala Gln Val Leu Thr Gln Thr Pro Ser Ser Val Ser Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Asn Cys 
            20              


<210>  304
<211>  13
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  304

Gln Ser Ser Gln Ser Val Tyr Lys Asn Lys Tyr Leu Ser 
1               5                   10              


<210>  305
<211>  15
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  305

Trp Tyr Gln Gln Lys Val Gly Gln Pro Pro Lys Phe Leu Ile Tyr 
1               5                   10                  15  


<210>  306
<211>  7
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  306

Gln Ala Ser Asn Leu Ala Ser 
1               5           


<210>  307
<211>  32
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  307

Gly Val Pro Ser Arg Phe Lys Gly Ser Gly Ser Gly Thr Gln Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Asp Leu Glu Cys Asp Asp Ala Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  308
<211>  10
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  308

Ala Gly Gly Tyr Ser Gly Asn Met Val Asp 
1               5                   10  


<210>  309
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  309

Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg 
1               5                   10      


<210>  310
<211>  106
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  310

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105     


<210>  311
<211>  651
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  311
gcccaagtgc tgacccagac tccatcgtcc gtgtctgcag ctgtgggagg cacagtcacc       60

atcaattgcc agtccagtca gagtgtttat aagaataagt acttatcctg gtatcagcag      120

aaagtagggc agcctcccaa gttcctgatc taccaggcat ccaatttggc atctggggtc      180

ccatcgcggt tcaaaggcag tggatctggg acacagttca ctctcaccat cagcgacctg      240

gagtgtgacg atgccgccac ttattactgt gcaggcggtt atagtggtaa tatggttgat      300

ttcggcggag ggaccgaggt ggtggtcaaa cgtacggtag cggccccatc tgtcttcatc      360

ttcccgccat ctgatgagca gttgaaatct ggaactgcct ctgttgtgtg cctgctgaat      420

aacttctatc ccagagaggc caaagtacag tggaaggtgg ataacgccct ccaatcgggt      480

aactcccagg agagtgtcac agagcaggac agcaaggaca gcacctacag cctcagcagc      540

accctgacgc tgagcaaagc agactacgag aaacacaaag tctacgcctg cgaagtcacc      600

catcagggcc tgagctcgcc cgtcacaaag agcttcaaca ggggagagtg t               651


<210>  312
<211>  333
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  312
gcccaagtgc tgacccagac tccatcgtcc gtgtctgcag ctgtgggagg cacagtcacc       60

atcaattgcc agtccagtca gagtgtttat aagaataagt acttatcctg gtatcagcag      120

aaagtagggc agcctcccaa gttcctgatc taccaggcat ccaatttggc atctggggtc      180

ccatcgcggt tcaaaggcag tggatctggg acacagttca ctctcaccat cagcgacctg      240

gagtgtgacg atgccgccac ttattactgt gcaggcggtt atagtggtaa tatggttgat      300

ttcggcggag ggaccgaggt ggtggtcaaa cgt                                   333


<210>  313
<211>  69
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  313
gcccaagtgc tgacccagac tccatcgtcc gtgtctgcag ctgtgggagg cacagtcacc       60

atcaattgc                                                               69


<210>  314
<211>  39
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  314
cagtccagtc agagtgttta taagaataag tacttatcc                              39


<210>  315
<211>  45
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  315
tggtatcagc agaaagtagg gcagcctccc aagttcctga tctac                       45


<210>  316
<211>  21
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  316
caggcatcca atttggcatc t                                                 21


<210>  317
<211>  96
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  317
ggggtcccat cgcggttcaa aggcagtgga tctgggacac agttcactct caccatcagc       60

gacctggagt gtgacgatgc cgccacttat tactgt                                 96


<210>  318
<211>  30
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  318
gcaggcggtt atagtggtaa tatggttgat                                        30


<210>  319
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  319
ttcggcggag ggaccgaggt ggtggtcaaa cgt                                    33


<210>  320
<211>  318
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  320
acggtagcgg ccccatctgt cttcatcttc ccgccatctg atgagcagtt gaaatctgga       60

actgcctctg ttgtgtgcct gctgaataac ttctatccca gagaggccaa agtacagtgg      120

aaggtggata acgccctcca atcgggtaac tcccaggaga gtgtcacaga gcaggacagc      180

aaggacagca cctacagcct cagcagcacc ctgacgctga gcaaagcaga ctacgagaaa      240

cacaaagtct acgcctgcga agtcacccat cagggcctga gctcgcccgt cacaaagagc      300

ttcaacaggg gagagtgt                                                    318


<210>  321
<211>  443
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  321

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Ser Ala Ala 
            20                  25                  30          


Leu Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Ile Ile Asp Lys Gly Val Met Ser Tyr Tyr Ala Ser Trp Ala Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr Val Asp Leu Lys Val 
65                  70                  75                  80  


Thr Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Gly 
                85                  90                  95      


Gly Gly Glu Phe Phe Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
        115                 120                 125             


Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
    130                 135                 140                 


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
145                 150                 155                 160 


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
                165                 170                 175     


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
            180                 185                 190         


Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
        195                 200                 205             


Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
    210                 215                 220                 


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
225                 230                 235                 240 


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
                245                 250                 255     


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
            260                 265                 270         


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
        275                 280                 285             


Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
    290                 295                 300                 


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
305                 310                 315                 320 


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
                325                 330                 335     


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
            340                 345                 350         


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
        355                 360                 365             


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
    370                 375                 380                 


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
385                 390                 395                 400 


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
                405                 410                 415     


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
            420                 425                 430         


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440             


<210>  322
<211>  113
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  322

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Ser Ala Ala 
            20                  25                  30          


Leu Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Ile Ile Asp Lys Gly Val Met Ser Tyr Tyr Ala Ser Trp Ala Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr Val Asp Leu Lys Val 
65                  70                  75                  80  


Thr Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Gly 
                85                  90                  95      


Gly Gly Glu Phe Phe Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  323
<211>  29
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  323

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser 
            20                  25                  


<210>  324
<211>  5
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  324

Ser Ala Ala Leu Ser 
1               5   


<210>  325
<211>  14
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  325

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
1               5                   10                  


<210>  326
<211>  16
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  326

Ile Ile Asp Lys Gly Val Met Ser Tyr Tyr Ala Ser Trp Ala Lys Gly 
1               5                   10                  15      


<210>  327
<211>  31
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  327

Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr Val Asp Leu Lys Val 
1               5                   10                  15      


Thr Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg 
            20                  25                  30      


<210>  328
<211>  7
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  328

Gly Gly Gly Glu Phe Phe Ile 
1               5           


<210>  329
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  329

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  330
<211>  330
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  330

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  331
<211>  1329
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  331
cagtcggtgg aggagtccgg gggtcgcctg gtcacgcctg ggacacccct gacactcacc       60

tgcaccgtct ctggattctc cctcagtagc gctgcattga gctgggtccg ccaggctcca      120

gggaaggggc tggaatggat cggaattatt gataagggtg ttatgtctta ctacgcgtcc      180

tgggcgaaag gccgattcac catctccaaa acctcgtcga ccacggtgga tctaaaagtg      240

accagtccga caaccgagga cacggccacc tatttctgtg ccagaggggg gggggaattt      300

ttcatctggg gccagggcac cctcgtcacc gtctcgagcg cctccaccaa gggcccatcg      360

gtcttccccc tggcaccctc ctccaagagc acctctgggg gcacagcggc cctgggctgc      420

ctggtcaagg actacttccc cgaaccggtg acggtgtcgt ggaactcagg cgccctgacc      480

agcggcgtgc acaccttccc ggctgtccta cagtcctcag gactctactc cctcagcagc      540

gtggtgaccg tgccctccag cagcttgggc acccagacct acatctgcaa cgtgaatcac      600

aagcccagca acaccaaggt ggacaagaaa gttgagccca aatcttgtga caaaactcac      660

acatgcccac cgtgcccagc acctgaactc ctggggggac cgtcagtctt cctcttcccc      720

ccaaaaccca aggacaccct catgatctcc cggacccctg aggtcacatg cgtggtggtg      780

gacgtgagcc acgaagaccc tgaggtcaag ttcaactggt acgtggacgg cgtggaggtg      840

cataatgcca agacaaagcc gcgggaggag cagtacgcca gcacgtaccg tgtggtcagc      900

gtcctcaccg tcctgcacca ggactggctg aatggcaagg agtacaagtg caaggtctcc      960

aacaaagccc tcccagcccc catcgagaaa accatctcca aagccaaagg gcagccccga     1020

gaaccacagg tgtacaccct gcccccatcc cgggaggaga tgaccaagaa ccaggtcagc     1080

ctgacctgcc tggtcaaagg cttctatccc agcgacatcg ccgtggagtg ggagagcaat     1140

gggcagccgg agaacaacta caagaccacg cctcccgtgc tggactccga cggctccttc     1200

ttcctctaca gcaagctcac cgtggacaag agcaggtggc agcaggggaa cgtcttctca     1260

tgctccgtga tgcatgaggc tctgcacaac cactacacgc agaagagcct ctccctgtct     1320

ccgggtaaa                                                             1329


<210>  332
<211>  339
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  332
cagtcggtgg aggagtccgg gggtcgcctg gtcacgcctg ggacacccct gacactcacc       60

tgcaccgtct ctggattctc cctcagtagc gctgcattga gctgggtccg ccaggctcca      120

gggaaggggc tggaatggat cggaattatt gataagggtg ttatgtctta ctacgcgtcc      180

tgggcgaaag gccgattcac catctccaaa acctcgtcga ccacggtgga tctaaaagtg      240

accagtccga caaccgagga cacggccacc tatttctgtg ccagaggggg gggggaattt      300

ttcatctggg gccagggcac cctcgtcacc gtctcgagc                             339


<210>  333
<211>  87
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  333
cagtcggtgg aggagtccgg gggtcgcctg gtcacgcctg ggacacccct gacactcacc       60

tgcaccgtct ctggattctc cctcagt                                           87


<210>  334
<211>  15
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  334
agcgctgcat tgagc                                                        15


<210>  335
<211>  42
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  335
tgggtccgcc aggctccagg gaaggggctg gaatggatcg ga                          42


<210>  336
<211>  48
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  336
attattgata agggtgttat gtcttactac gcgtcctggg cgaaaggc                    48


<210>  337
<211>  93
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  337
cgattcacca tctccaaaac ctcgtcgacc acggtggatc taaaagtgac cagtccgaca       60

accgaggaca cggccaccta tttctgtgcc aga                                    93


<210>  338
<211>  21
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  338
gggggggggg aatttttcat c                                                 21


<210>  339
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  339
tggggccagg gcaccctcgt caccgtctcg agc                                    33


<210>  340
<211>  990
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  340
gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg       60

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      240

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttgagccc      300

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      360

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      420

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      480

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacgcc      540

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      600

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc      660

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggaggag      720

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc      780

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg      840

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg      900

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg      960

cagaagagcc tctccctgtc tccgggtaaa                                       990


<210>  341
<211>  217
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  341

Ala Gln Val Leu Thr Gln Thr Pro Ser Ser Val Ser Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Asn Cys Gln Ser Ser Lys Ser Val Tyr Asn Asn 
            20                  25                  30          


Asn Trp Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Phe 
        35                  40                  45              


Leu Ile Tyr Gln Ala Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe 
    50                  55                  60                  


Lys Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Asp Leu 
65                  70                  75                  80  


Glu Cys Asp Asp Ala Ala Thr Tyr Tyr Cys Ala Gly Gly Tyr Ser Gly 
                85                  90                  95      


Asn Ile Val Gly Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg Thr 
            100                 105                 110         


Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
        115                 120                 125             


Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
    130                 135                 140                 


Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
145                 150                 155                 160 


Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
                165                 170                 175     


Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
            180                 185                 190         


Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
        195                 200                 205             


Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215         


<210>  342
<211>  111
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  342

Ala Gln Val Leu Thr Gln Thr Pro Ser Ser Val Ser Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Asn Cys Gln Ser Ser Lys Ser Val Tyr Asn Asn 
            20                  25                  30          


Asn Trp Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Phe 
        35                  40                  45              


Leu Ile Tyr Gln Ala Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe 
    50                  55                  60                  


Lys Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Asp Leu 
65                  70                  75                  80  


Glu Cys Asp Asp Ala Ala Thr Tyr Tyr Cys Ala Gly Gly Tyr Ser Gly 
                85                  90                  95      


Asn Ile Val Gly Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg 
            100                 105                 110     


<210>  343
<211>  23
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  343

Ala Gln Val Leu Thr Gln Thr Pro Ser Ser Val Ser Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Asn Cys 
            20              


<210>  344
<211>  13
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  344

Gln Ser Ser Lys Ser Val Tyr Asn Asn Asn Trp Leu Ser 
1               5                   10              


<210>  345
<211>  15
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  345

Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Phe Leu Ile Tyr 
1               5                   10                  15  


<210>  346
<211>  7
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  346

Gln Ala Ser Asn Leu Ala Ser 
1               5           


<210>  347
<211>  32
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  347

Gly Val Pro Ser Arg Phe Lys Gly Ser Gly Ser Gly Thr Gln Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Asp Leu Glu Cys Asp Asp Ala Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  348
<211>  10
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  348

Ala Gly Gly Tyr Ser Gly Asn Ile Val Gly 
1               5                   10  


<210>  349
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  349

Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg 
1               5                   10      


<210>  350
<211>  106
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  350

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105     


<210>  351
<211>  651
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  351
gcgcaagtgc tgacccagac tccatcgtcc gtgtctgcag ctgtgggagg cacagtcacc       60

atcaattgcc agtccagtaa gagtgtttat aacaacaatt ggttatcctg gtatcaacag      120

aaaccagggc agcctcccaa gttcctgatc taccaggcat ccaatttggc atctggggtc      180

ccgtcgcggt tcaaaggcag tggatctggg acacagttca ctctcaccat cagcgacctc      240

gagtgtgacg atgccgccac ttattactgt gcaggcggtt atagtggtaa tattgttggt      300

ttcggcggag ggaccgaggt ggtggtcaaa cgtacggtag cggccccatc tgtcttcatc      360

ttcccgccat ctgatgagca gttgaaatct ggaactgcct ctgttgtgtg cctgctgaat      420

aacttctatc ccagagaggc caaagtacag tggaaggtgg ataacgccct ccaatcgggt      480

aactcccagg agagtgtcac agagcaggac agcaaggaca gcacctacag cctcagcagc      540

accctgacgc tgagcaaagc agactacgag aaacacaaag tctacgcctg cgaagtcacc      600

catcagggcc tgagctcgcc cgtcacaaag agcttcaaca ggggagagtg t               651


<210>  352
<211>  333
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  352
gcgcaagtgc tgacccagac tccatcgtcc gtgtctgcag ctgtgggagg cacagtcacc       60

atcaattgcc agtccagtaa gagtgtttat aacaacaatt ggttatcctg gtatcaacag      120

aaaccagggc agcctcccaa gttcctgatc taccaggcat ccaatttggc atctggggtc      180

ccgtcgcggt tcaaaggcag tggatctggg acacagttca ctctcaccat cagcgacctc      240

gagtgtgacg atgccgccac ttattactgt gcaggcggtt atagtggtaa tattgttggt      300

ttcggcggag ggaccgaggt ggtggtcaaa cgt                                   333


<210>  353
<211>  69
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  353
gcgcaagtgc tgacccagac tccatcgtcc gtgtctgcag ctgtgggagg cacagtcacc       60

atcaattgc                                                               69


<210>  354
<211>  39
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  354
cagtccagta agagtgttta taacaacaat tggttatcc                              39


<210>  355
<211>  45
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  355
tggtatcaac agaaaccagg gcagcctccc aagttcctga tctac                       45


<210>  356
<211>  21
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  356
caggcatcca atttggcatc t                                                 21


<210>  357
<211>  96
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  357
ggggtcccgt cgcggttcaa aggcagtgga tctgggacac agttcactct caccatcagc       60

gacctcgagt gtgacgatgc cgccacttat tactgt                                 96


<210>  358
<211>  30
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  358
gcaggcggtt atagtggtaa tattgttggt                                        30


<210>  359
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  359
ttcggcggag ggaccgaggt ggtggtcaaa cgt                                    33


<210>  360
<211>  318
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  360
acggtagcgg ccccatctgt cttcatcttc ccgccatctg atgagcagtt gaaatctgga       60

actgcctctg ttgtgtgcct gctgaataac ttctatccca gagaggccaa agtacagtgg      120

aaggtggata acgccctcca atcgggtaac tcccaggaga gtgtcacaga gcaggacagc      180

aaggacagca cctacagcct cagcagcacc ctgacgctga gcaaagcaga ctacgagaaa      240

cacaaagtct acgcctgcga agtcacccat cagggcctga gctcgcccgt cacaaagagc      300

ttcaacaggg gagagtgt                                                    318


<210>  361
<211>  443
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  361

Gln Ser Val Glu Ala Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Ser Ala Thr 
            20                  25                  30          


Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Leu Ile Gly Gly Asn Asp Glu Arg Tyr Tyr Ala Ser Trp Ala Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr Val Asp Leu Lys Met 
65                  70                  75                  80  


Thr Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Gly 
                85                  90                  95      


Gly Gly Glu Phe Phe Ile Trp Gly Pro Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
        115                 120                 125             


Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
    130                 135                 140                 


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
145                 150                 155                 160 


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
                165                 170                 175     


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
            180                 185                 190         


Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
        195                 200                 205             


Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
    210                 215                 220                 


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
225                 230                 235                 240 


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
                245                 250                 255     


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
            260                 265                 270         


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
        275                 280                 285             


Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
    290                 295                 300                 


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
305                 310                 315                 320 


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
                325                 330                 335     


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
            340                 345                 350         


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
        355                 360                 365             


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
    370                 375                 380                 


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
385                 390                 395                 400 


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
                405                 410                 415     


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
            420                 425                 430         


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440             


<210>  362
<211>  113
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  362

Gln Ser Val Glu Ala Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Ser Ala Thr 
            20                  25                  30          


Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Leu Ile Gly Gly Asn Asp Glu Arg Tyr Tyr Ala Ser Trp Ala Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr Val Asp Leu Lys Met 
65                  70                  75                  80  


Thr Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Gly 
                85                  90                  95      


Gly Gly Glu Phe Phe Ile Trp Gly Pro Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  363
<211>  29
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  363

Gln Ser Val Glu Ala Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser 
            20                  25                  


<210>  364
<211>  5
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  364

Ser Ala Thr Met Asn 
1               5   


<210>  365
<211>  14
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  365

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
1               5                   10                  


<210>  366
<211>  16
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  366

Leu Ile Gly Gly Asn Asp Glu Arg Tyr Tyr Ala Ser Trp Ala Lys Gly 
1               5                   10                  15      


<210>  367
<211>  31
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  367

Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr Val Asp Leu Lys Met 
1               5                   10                  15      


Thr Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg 
            20                  25                  30      


<210>  368
<211>  7
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  368

Gly Gly Gly Glu Phe Phe Ile 
1               5           


<210>  369
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  369

Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  370
<211>  330
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  370

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  371
<211>  1329
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  371
cagtcggtgg aggcgtccgg gggtcgcctg gtcacgcctg ggacacccct gacactcacc       60

tgcaccgtct ctggattctc cctcagtagc gctacaatga actgggtccg ccaggctcca      120

gggaaggggc tggaatggat cgggcttatt ggcggtaatg acgaaagata ctacgcgtcc      180

tgggcgaaag gccgattcac catctccaaa acctcgtcga ccacggtgga tctgaaaatg      240

accagtccga caaccgagga cacggccacc tatttctgtg ccagaggggg gggggaattt      300

ttcatctggg gcccgggcac cctggtcacc gtctcgagcg cctccaccaa gggcccatcg      360

gtcttccccc tggcaccctc ctccaagagc acctctgggg gcacagcggc cctgggctgc      420

ctggtcaagg actacttccc cgaaccggtg acggtgtcgt ggaactcagg cgccctgacc      480

agcggcgtgc acaccttccc ggctgtccta cagtcctcag gactctactc cctcagcagc      540

gtggtgaccg tgccctccag cagcttgggc acccagacct acatctgcaa cgtgaatcac      600

aagcccagca acaccaaggt ggacaagaaa gttgagccca aatcttgtga caaaactcac      660

acatgcccac cgtgcccagc acctgaactc ctggggggac cgtcagtctt cctcttcccc      720

ccaaaaccca aggacaccct catgatctcc cggacccctg aggtcacatg cgtggtggtg      780

gacgtgagcc acgaagaccc tgaggtcaag ttcaactggt acgtggacgg cgtggaggtg      840

cataatgcca agacaaagcc gcgggaggag cagtacgcca gcacgtaccg tgtggtcagc      900

gtcctcaccg tcctgcacca ggactggctg aatggcaagg agtacaagtg caaggtctcc      960

aacaaagccc tcccagcccc catcgagaaa accatctcca aagccaaagg gcagccccga     1020

gaaccacagg tgtacaccct gcccccatcc cgggaggaga tgaccaagaa ccaggtcagc     1080

ctgacctgcc tggtcaaagg cttctatccc agcgacatcg ccgtggagtg ggagagcaat     1140

gggcagccgg agaacaacta caagaccacg cctcccgtgc tggactccga cggctccttc     1200

ttcctctaca gcaagctcac cgtggacaag agcaggtggc agcaggggaa cgtcttctca     1260

tgctccgtga tgcatgaggc tctgcacaac cactacacgc agaagagcct ctccctgtct     1320

ccgggtaaa                                                             1329


<210>  372
<211>  339
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  372
cagtcggtgg aggcgtccgg gggtcgcctg gtcacgcctg ggacacccct gacactcacc       60

tgcaccgtct ctggattctc cctcagtagc gctacaatga actgggtccg ccaggctcca      120

gggaaggggc tggaatggat cgggcttatt ggcggtaatg acgaaagata ctacgcgtcc      180

tgggcgaaag gccgattcac catctccaaa acctcgtcga ccacggtgga tctgaaaatg      240

accagtccga caaccgagga cacggccacc tatttctgtg ccagaggggg gggggaattt      300

ttcatctggg gcccgggcac cctggtcacc gtctcgagc                             339


<210>  373
<211>  87
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  373
cagtcggtgg aggcgtccgg gggtcgcctg gtcacgcctg ggacacccct gacactcacc       60

tgcaccgtct ctggattctc cctcagt                                           87


<210>  374
<211>  15
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  374
agcgctacaa tgaac                                                        15


<210>  375
<211>  42
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  375
tgggtccgcc aggctccagg gaaggggctg gaatggatcg gg                          42


<210>  376
<211>  48
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  376
cttattggcg gtaatgacga aagatactac gcgtcctggg cgaaaggc                    48


<210>  377
<211>  93
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  377
cgattcacca tctccaaaac ctcgtcgacc acggtggatc tgaaaatgac cagtccgaca       60

accgaggaca cggccaccta tttctgtgcc aga                                    93


<210>  378
<211>  21
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  378
gggggggggg aatttttcat c                                                 21


<210>  379
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  379
tggggcccgg gcaccctggt caccgtctcg agc                                    33


<210>  380
<211>  990
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  380
gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg       60

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      240

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttgagccc      300

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      360

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      420

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      480

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacgcc      540

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      600

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc      660

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggaggag      720

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc      780

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg      840

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg      900

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg      960

cagaagagcc tctccctgtc tccgggtaaa                                       990


<210>  381
<211>  217
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  381

Ala Gln Val Leu Thr Gln Thr Pro Ser Ser Val Ser Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Asn Cys Gln Ser Ser Glu Ser Val Tyr Thr Asn 
            20                  25                  30          


Asp Arg Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Glu Ala Ser Lys Leu Ala Ser Gly Val Pro Pro Arg Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Asp Leu 
65                  70                  75                  80  


Glu Cys Asp Asp Ala Ala Thr Tyr Tyr Cys Ala Gly Ala Tyr Ser Thr 
                85                  90                  95      


Ser Ile His Gly Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg Thr 
            100                 105                 110         


Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
        115                 120                 125             


Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
    130                 135                 140                 


Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
145                 150                 155                 160 


Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
                165                 170                 175     


Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
            180                 185                 190         


Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
        195                 200                 205             


Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215         


<210>  382
<211>  111
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  382

Ala Gln Val Leu Thr Gln Thr Pro Ser Ser Val Ser Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Asn Cys Gln Ser Ser Glu Ser Val Tyr Thr Asn 
            20                  25                  30          


Asp Arg Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Glu Ala Ser Lys Leu Ala Ser Gly Val Pro Pro Arg Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Asp Leu 
65                  70                  75                  80  


Glu Cys Asp Asp Ala Ala Thr Tyr Tyr Cys Ala Gly Ala Tyr Ser Thr 
                85                  90                  95      


Ser Ile His Gly Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg 
            100                 105                 110     


<210>  383
<211>  23
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  383

Ala Gln Val Leu Thr Gln Thr Pro Ser Ser Val Ser Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Asn Cys 
            20              


<210>  384
<211>  13
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  384

Gln Ser Ser Glu Ser Val Tyr Thr Asn Asp Arg Leu Ser 
1               5                   10              


<210>  385
<211>  15
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  385

Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  386
<211>  7
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  386

Glu Ala Ser Lys Leu Ala Ser 
1               5           


<210>  387
<211>  32
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  387

Gly Val Pro Pro Arg Phe Ser Gly Ser Gly Ser Gly Thr Gln Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Asp Leu Glu Cys Asp Asp Ala Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  388
<211>  10
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  388

Ala Gly Ala Tyr Ser Thr Ser Ile His Gly 
1               5                   10  


<210>  389
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  389

Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg 
1               5                   10      


<210>  390
<211>  106
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  390

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105     


<210>  391
<211>  651
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  391
gcgcaagtgc tgacccagac tccatcgtcc gtgtctgcag ctgtgggagg cacagtcacc       60

atcaattgcc agtccagtga gagtgtttat actaacgacc gcttatcctg gtatcagcag      120

aaaccagggc agcctcccaa gctcctgatc tacgaagcat ccaagctggc atctggggtc      180

ccaccgcggt tcagcggcag tggatctggg acacagttca ctctcaccat cagcgacctg      240

gagtgtgacg atgccgccac ttattactgt gcaggcgctt atagtactag tatccatggt      300

ttcggcggag ggaccgaggt ggtggtcaaa cgtacggtag cggccccatc tgtcttcatc      360

ttcccgccat ctgatgagca gttgaaatct ggaactgcct ctgttgtgtg cctgctgaat      420

aacttctatc ccagagaggc caaagtacag tggaaggtgg ataacgccct ccaatcgggt      480

aactcccagg agagtgtcac agagcaggac agcaaggaca gcacctacag cctcagcagc      540

accctgacgc tgagcaaagc agactacgag aaacacaaag tctacgcctg cgaagtcacc      600

catcagggcc tgagctcgcc cgtcacaaag agcttcaaca ggggagagtg t               651


<210>  392
<211>  333
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  392
gcgcaagtgc tgacccagac tccatcgtcc gtgtctgcag ctgtgggagg cacagtcacc       60

atcaattgcc agtccagtga gagtgtttat actaacgacc gcttatcctg gtatcagcag      120

aaaccagggc agcctcccaa gctcctgatc tacgaagcat ccaagctggc atctggggtc      180

ccaccgcggt tcagcggcag tggatctggg acacagttca ctctcaccat cagcgacctg      240

gagtgtgacg atgccgccac ttattactgt gcaggcgctt atagtactag tatccatggt      300

ttcggcggag ggaccgaggt ggtggtcaaa cgt                                   333


<210>  393
<211>  69
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  393
gcgcaagtgc tgacccagac tccatcgtcc gtgtctgcag ctgtgggagg cacagtcacc       60

atcaattgc                                                               69


<210>  394
<211>  39
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  394
cagtccagtg agagtgttta tactaacgac cgcttatcc                              39


<210>  395
<211>  45
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  395
tggtatcagc agaaaccagg gcagcctccc aagctcctga tctac                       45


<210>  396
<211>  21
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  396
gaagcatcca agctggcatc t                                                 21


<210>  397
<211>  96
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  397
ggggtcccac cgcggttcag cggcagtgga tctgggacac agttcactct caccatcagc       60

gacctggagt gtgacgatgc cgccacttat tactgt                                 96


<210>  398
<211>  30
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  398
gcaggcgctt atagtactag tatccatggt                                        30


<210>  399
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  399
ttcggcggag ggaccgaggt ggtggtcaaa cgt                                    33


<210>  400
<211>  318
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  400
acggtagcgg ccccatctgt cttcatcttc ccgccatctg atgagcagtt gaaatctgga       60

actgcctctg ttgtgtgcct gctgaataac ttctatccca gagaggccaa agtacagtgg      120

aaggtggata acgccctcca atcgggtaac tcccaggaga gtgtcacaga gcaggacagc      180

aaggacagca cctacagcct cagcagcacc ctgacgctga gcaaagcaga ctacgagaaa      240

cacaaagtct acgcctgcga agtcacccat cagggcctga gctcgcccgt cacaaagagc      300

ttcaacaggg gagagtgt                                                    318

<210>  401

<400>  401
000

<210>  402

<400>  402
000

<210>  403

<400>  403
000

<210>  404

<400>  404
000

<210>  405

<400>  405
000

<210>  406

<400>  406
000

<210>  407

<400>  407
000

<210>  408

<400>  408
000

<210>  409

<400>  409
000

<210>  410

<400>  410
000

<210>  411

<400>  411
000

<210>  412

<400>  412
000

<210>  413

<400>  413
000

<210>  414

<400>  414
000

<210>  415

<400>  415
000

<210>  416

<400>  416
000

<210>  417

<400>  417
000

<210>  418

<400>  418
000

<210>  419

<400>  419
000

<210>  420

<400>  420
000

<210>  421

<400>  421
000

<210>  422

<400>  422
000

<210>  423

<400>  423
000

<210>  424

<400>  424
000

<210>  425

<400>  425
000

<210>  426

<400>  426
000

<210>  427

<400>  427
000

<210>  428

<400>  428
000

<210>  429

<400>  429
000

<210>  430

<400>  430
000

<210>  431

<400>  431
000

<210>  432

<400>  432
000

<210>  433

<400>  433
000

<210>  434

<400>  434
000

<210>  435

<400>  435
000

<210>  436

<400>  436
000

<210>  437

<400>  437
000

<210>  438

<400>  438
000

<210>  439

<400>  439
000

<210>  440

<400>  440
000

<210>  441

<400>  441
000

<210>  442

<400>  442
000

<210>  443

<400>  443
000

<210>  444

<400>  444
000

<210>  445

<400>  445
000

<210>  446

<400>  446
000

<210>  447

<400>  447
000

<210>  448

<400>  448
000

<210>  449

<400>  449
000

<210>  450

<400>  450
000

<210>  451

<400>  451
000

<210>  452

<400>  452
000

<210>  453

<400>  453
000

<210>  454

<400>  454
000

<210>  455

<400>  455
000

<210>  456

<400>  456
000

<210>  457

<400>  457
000

<210>  458

<400>  458
000

<210>  459

<400>  459
000

<210>  460

<400>  460
000

<210>  461

<400>  461
000

<210>  462

<400>  462
000

<210>  463

<400>  463
000

<210>  464

<400>  464
000

<210>  465

<400>  465
000

<210>  466

<400>  466
000

<210>  467

<400>  467
000

<210>  468

<400>  468
000

<210>  469

<400>  469
000

<210>  470

<400>  470
000

<210>  471

<400>  471
000

<210>  472

<400>  472
000

<210>  473

<400>  473
000

<210>  474

<400>  474
000

<210>  475

<400>  475
000

<210>  476

<400>  476
000

<210>  477

<400>  477
000

<210>  478

<400>  478
000

<210>  479

<400>  479
000

<210>  480

<400>  480
000

<210>  481
<211>  445
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  481

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Ser Tyr Ala 
            20                  25                  30          


Met Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Ile Ile Tyr Asp Asn Gly Asp Thr Tyr Tyr Ala Ser Trp Ala Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Tyr Leu Lys Ile Ala 
65                  70                  75                  80  


Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Glu Pro 
                85                  90                  95      


Gly Ser Thr Thr Gln Asn Asp Leu Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
        115                 120                 125             


Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val 
    130                 135                 140                 


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
145                 150                 155                 160 


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
                165                 170                 175     


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
            180                 185                 190         


Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys 
        195                 200                 205             


Val Asp Ala Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys 
    210                 215                 220                 


Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
225                 230                 235                 240 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                245                 250                 255     


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            260                 265                 270         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        275                 280                 285             


Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu 
    290                 295                 300                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
305                 310                 315                 320 


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                325                 330                 335     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            340                 345                 350         


Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        355                 360                 365             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    370                 375                 380                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
385                 390                 395                 400 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                405                 410                 415     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            420                 425                 430         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445 


<210>  482
<211>  115
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  482

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Ser Tyr Ala 
            20                  25                  30          


Met Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Ile Ile Tyr Asp Asn Gly Asp Thr Tyr Tyr Ala Ser Trp Ala Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Tyr Leu Lys Ile Ala 
65                  70                  75                  80  


Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Glu Pro 
                85                  90                  95      


Gly Ser Thr Thr Gln Asn Asp Leu Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  483
<211>  29
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  483

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser 
            20                  25                  


<210>  484
<211>  5
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  484

Ser Tyr Ala Met Ile 
1               5   


<210>  485
<211>  14
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  485

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
1               5                   10                  


<210>  486
<211>  16
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  486

Ile Ile Tyr Asp Asn Gly Asp Thr Tyr Tyr Ala Ser Trp Ala Lys Gly 
1               5                   10                  15      


<210>  487
<211>  30
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  487

Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Tyr Leu Lys Ile Ala 
1               5                   10                  15      


Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg 
            20                  25                  30  


<210>  488
<211>  10
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  488

Glu Pro Gly Ser Thr Thr Gln Asn Asp Leu 
1               5                   10  


<210>  489
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  489

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  490
<211>  330
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  490

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Ala 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  491
<211>  1335
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  491
cagtcggtgg aggagtccgg gggtcgcctg gtcacgcctg ggacacccct gacactcacc       60

tgcacagtct ctggattctc cctcagtagc tatgcgatga tctgggtccg ccaggctcca      120

gggaaggggc tggaatggat cggaatcatt tatgataatg gtgacacata ctacgcgagc      180

tgggcgaaag gccggttcac catctccaaa acctcgacca cggtgtatct gaagatcgcc      240

agtccgacaa ccgaggacac ggccacctac ttctgtgcca gagagcctgg tagtactact      300

cagaatgact tgtggggcca agggaccctg gtcaccgtct cgagcgcctc caccaagggc      360

ccatcggtct tccccctggc accctcctcc aagagcacct ctgggggcac agcggccctg      420

ggctgcctgg tcaaggacta cttccccgaa ccggtgacgg tgtcgtggaa ctcaggcgcc      480

ctgaccagcg gcgtgcacac cttcccggct gtcctacagt cctcaggact ctactccctc      540

agcagcgtgg tgaccgtgcc ctccagcagc ttgggcaccc agacctacat ctgcaacgtg      600

aatcacaagc ccagcaacac caaggtggac gcgagagttg agcccaaatc ttgtgacaaa      660

actcacacat gcccaccgtg cccagcacct gaactcctgg ggggaccgtc agtcttcctc      720

ttccccccaa aacccaagga caccctcatg atctcccgga cccctgaggt cacatgcgtg      780

gtggtggacg tgagccacga agaccctgag gtcaagttca actggtacgt ggacggcgtg      840

gaggtgcata atgccaagac aaagccgcgg gaggagcagt acgccagcac gtaccgtgtg      900

gtcagcgtcc tcaccgtcct gcaccaggac tggctgaatg gcaaggagta caagtgcaag      960

gtctccaaca aagccctccc agcccccatc gagaaaacca tctccaaagc caaagggcag     1020

ccccgagaac cacaggtgta caccctgccc ccatcccggg aggagatgac caagaaccag     1080

gtcagcctga cctgcctggt caaaggcttc tatcccagcg acatcgccgt ggagtgggag     1140

agcaatgggc agccggagaa caactacaag accacgcctc ccgtgctgga ctccgacggc     1200

tccttcttcc tctacagcaa gctcaccgtg gacaagagca ggtggcagca ggggaacgtc     1260

ttctcatgct ccgtgatgca tgaggctctg cacaaccact acacgcagaa gagcctctcc     1320

ctgtctccgg gtaaa                                                      1335


<210>  492
<211>  345
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  492
cagtcggtgg aggagtccgg gggtcgcctg gtcacgcctg ggacacccct gacactcacc       60

tgcacagtct ctggattctc cctcagtagc tatgcgatga tctgggtccg ccaggctcca      120

gggaaggggc tggaatggat cggaatcatt tatgataatg gtgacacata ctacgcgagc      180

tgggcgaaag gccggttcac catctccaaa acctcgacca cggtgtatct gaagatcgcc      240

agtccgacaa ccgaggacac ggccacctac ttctgtgcca gagagcctgg tagtactact      300

cagaatgact tgtggggcca agggaccctg gtcaccgtct cgagc                      345


<210>  493
<211>  87
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  493
cagtcggtgg aggagtccgg gggtcgcctg gtcacgcctg ggacacccct gacactcacc       60

tgcacagtct ctggattctc cctcagt                                           87


<210>  494
<211>  15
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  494
agctatgcga tgatc                                                        15


<210>  495
<211>  42
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  495
tgggtccgcc aggctccagg gaaggggctg gaatggatcg ga                          42


<210>  496
<211>  48
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  496
atcatttatg ataatggtga cacatactac gcgagctggg cgaaaggc                    48


<210>  497
<211>  90
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  497
cggttcacca tctccaaaac ctcgaccacg gtgtatctga agatcgccag tccgacaacc       60

gaggacacgg ccacctactt ctgtgccaga                                        90


<210>  498
<211>  30
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  498
gagcctggta gtactactca gaatgacttg                                        30


<210>  499
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  499
tggggccaag ggaccctggt caccgtctcg agc                                    33


<210>  500
<211>  990
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  500
gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg       60

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      240

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacgcgag agttgagccc      300

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      360

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      420

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      480

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacgcc      540

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      600

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc      660

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggaggag      720

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc      780

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg      840

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg      900

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg      960

cagaagagcc tctccctgtc tccgggtaaa                                       990


<210>  501
<211>  217
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  501

Asp Val Val Met Thr Gln Thr Pro Ala Ser Val Ser Glu Pro Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Glu Asn Ile Tyr Asn Ser 
            20                  25                  30          


Leu Leu Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Ser Thr Leu Ala Ser Gly Val Ser Ser Arg Phe Lys Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asp Leu Glu Cys 
65                  70                  75                  80  


Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Asn Tyr Tyr Asn Ile Trp Thr 
                85                  90                  95      


Asn Gly Ala Ala Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg Thr 
            100                 105                 110         


Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
        115                 120                 125             


Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
    130                 135                 140                 


Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
145                 150                 155                 160 


Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
                165                 170                 175     


Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
            180                 185                 190         


Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
        195                 200                 205             


Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215         


<210>  502
<211>  111
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  502

Asp Val Val Met Thr Gln Thr Pro Ala Ser Val Ser Glu Pro Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Glu Asn Ile Tyr Asn Ser 
            20                  25                  30          


Leu Leu Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Ser Thr Leu Ala Ser Gly Val Ser Ser Arg Phe Lys Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asp Leu Glu Cys 
65                  70                  75                  80  


Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Asn Tyr Tyr Asn Ile Trp Thr 
                85                  90                  95      


Asn Gly Ala Ala Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg 
            100                 105                 110     


<210>  503
<211>  23
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  503

Asp Val Val Met Thr Gln Thr Pro Ala Ser Val Ser Glu Pro Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Lys Cys 
            20              


<210>  504
<211>  11
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  504

Gln Ala Ser Glu Asn Ile Tyr Asn Ser Leu Leu 
1               5                   10      


<210>  505
<211>  15
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  505

Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  506
<211>  7
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  506

Arg Ala Ser Thr Leu Ala Ser 
1               5           


<210>  507
<211>  32
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  507

Gly Val Ser Ser Arg Phe Lys Gly Ser Gly Ser Gly Thr Glu Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Asp Leu Glu Cys Ala Asp Ala Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  508
<211>  12
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  508

Gln Asn Tyr Tyr Asn Ile Trp Thr Asn Gly Ala Ala 
1               5                   10          


<210>  509
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  509

Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg 
1               5                   10      


<210>  510
<211>  106
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  510

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105     


<210>  511
<211>  651
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  511
gatgttgtga tgacccagac tccagcctcc gtgtctgaac ctgtgggagg cacagtcacc       60

atcaagtgcc aggccagtga gaacatttac aactctttac tctggtatca gcagaaacca      120

gggcagcctc ccaagctcct gatctatagg gcatccactc tggcatctgg ggtctcatcg      180

cggttcaaag gcagtggatc tgggacagag ttcactctca ccatcagcga cctggagtgt      240

gccgatgctg ccacttacta ctgtcaaaac tattataata tatggactaa tggtgctgct      300

ttcggcggag ggaccgaggt ggtggtcaaa cgtacggtag cggccccatc tgtcttcatc      360

ttcccgccat ctgatgagca gttgaaatct ggaactgcct ctgttgtgtg cctgctgaat      420

aacttctatc ccagagaggc caaagtacag tggaaggtgg ataacgccct ccaatcgggt      480

aactcccagg agagtgtcac agagcaggac agcaaggaca gcacctacag cctcagcagc      540

accctgacgc tgagcaaagc agactacgag aaacacaaag tctacgcctg cgaagtcacc      600

catcagggcc tgagctcgcc cgtcacaaag agcttcaaca ggggagagtg t               651


<210>  512
<211>  333
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  512
gatgttgtga tgacccagac tccagcctcc gtgtctgaac ctgtgggagg cacagtcacc       60

atcaagtgcc aggccagtga gaacatttac aactctttac tctggtatca gcagaaacca      120

gggcagcctc ccaagctcct gatctatagg gcatccactc tggcatctgg ggtctcatcg      180

cggttcaaag gcagtggatc tgggacagag ttcactctca ccatcagcga cctggagtgt      240

gccgatgctg ccacttacta ctgtcaaaac tattataata tatggactaa tggtgctgct      300

ttcggcggag ggaccgaggt ggtggtcaaa cgt                                   333


<210>  513
<211>  69
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  513
gatgttgtga tgacccagac tccagcctcc gtgtctgaac ctgtgggagg cacagtcacc       60

atcaagtgc                                                               69


<210>  514
<211>  33
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  514
caggccagtg agaacattta caactcttta ctc                                    33


<210>  515
<211>  45
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  515
tggtatcagc agaaaccagg gcagcctccc aagctcctga tctat                       45


<210>  516
<211>  21
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  516
agggcatcca ctctggcatc t                                                 21


<210>  517
<211>  96
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  517
ggggtctcat cgcggttcaa aggcagtgga tctgggacag agttcactct caccatcagc       60

gacctggagt gtgccgatgc tgccacttac tactgt                                 96


<210>  518
<211>  36
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  518
caaaactatt ataatatatg gactaatggt gctgct                                 36


<210>  519
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  519
ttcggcggag ggaccgaggt ggtggtcaaa cgt                                    33


<210>  520
<211>  318
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  520
acggtagcgg ccccatctgt cttcatcttc ccgccatctg atgagcagtt gaaatctgga       60

actgcctctg ttgtgtgcct gctgaataac ttctatccca gagaggccaa agtacagtgg      120

aaggtggata acgccctcca atcgggtaac tcccaggaga gtgtcacaga gcaggacagc      180

aaggacagca cctacagcct cagcagcacc ctgacgctga gcaaagcaga ctacgagaaa      240

cacaaagtct acgcctgcga agtcacccat cagggcctga gctcgcccgt cacaaagagc      300

ttcaacaggg gagagtgt                                                    318


<210>  521
<211>  441
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  521

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Ala Ser Gly Ile Asp Leu Ser Gly Tyr Ala 
            20                  25                  30          


Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Asp Ile Ser Thr Tyr Gly Thr Thr Asp Tyr Ala Ser Trp Val Asn Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Arg Thr Ser Thr Thr Val Thr Leu Lys Met Thr 
65                  70                  75                  80  


Ser Leu Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Asp Tyr 
                85                  90                  95      


Trp Leu Ser Leu Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser Ala 
            100                 105                 110         


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
        115                 120                 125             


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
    130                 135                 140                 


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
145                 150                 155                 160 


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
                165                 170                 175     


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
            180                 185                 190         


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Ala Arg 
        195                 200                 205             


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
    210                 215                 220                 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
225                 230                 235                 240 


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
                245                 250                 255     


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
            260                 265                 270         


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
        275                 280                 285             


Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
    290                 295                 300                 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
305                 310                 315                 320 


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
                325                 330                 335     


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
            340                 345                 350         


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
        355                 360                 365             


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
    370                 375                 380                 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
385                 390                 395                 400 


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
                405                 410                 415     


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
            420                 425                 430         


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440     


<210>  522
<211>  111
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  522

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Ala Ser Gly Ile Asp Leu Ser Gly Tyr Ala 
            20                  25                  30          


Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Asp Ile Ser Thr Tyr Gly Thr Thr Asp Tyr Ala Ser Trp Val Asn Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Arg Thr Ser Thr Thr Val Thr Leu Lys Met Thr 
65                  70                  75                  80  


Ser Leu Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Asp Tyr 
                85                  90                  95      


Trp Leu Ser Leu Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 
            100                 105                 110     


<210>  523
<211>  29
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  523

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Ala Ser Gly Ile Asp Leu Ser 
            20                  25                  


<210>  524
<211>  5
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  524

Gly Tyr Ala Met Gly 
1               5   


<210>  525
<211>  14
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  525

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
1               5                   10                  


<210>  526
<211>  16
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  526

Asp Ile Ser Thr Tyr Gly Thr Thr Asp Tyr Ala Ser Trp Val Asn Gly 
1               5                   10                  15      


<210>  527
<211>  30
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  527

Arg Phe Thr Ile Ser Arg Thr Ser Thr Thr Val Thr Leu Lys Met Thr 
1               5                   10                  15      


Ser Leu Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg 
            20                  25                  30  


<210>  528
<211>  6
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  528

Asp Tyr Trp Leu Ser Leu 
1               5       


<210>  529
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  529

Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  530
<211>  330
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  530

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Ala 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  531
<211>  1323
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  531
cagtcggtgg aggagtccgg gggtcgcctg gtaacgcctg ggacacccct gacactcacc       60

tgcacagcct ctggaatcga cctcagtggc tatgcaatgg gctgggtccg ccaggctcca      120

gggaaggggc tggaatggat cggagacatt agtacctatg gtaccacaga ctacgcgagc      180

tgggtgaatg gccgattcac catctccaga acctcgacca cggtgactct gaaaatgacc      240

agtctgacaa ccgaggacac ggccacctat ttctgtgcca gagactattg gttgagcttg      300

tggggcccgg gcaccctcgt caccgtctcg agcgcctcca ccaagggccc atcggtcttc      360

cccctggcac cctcctccaa gagcacctct gggggcacag cggccctggg ctgcctggtc      420

aaggactact tccccgaacc ggtgacggtg tcgtggaact caggcgccct gaccagcggc      480

gtgcacacct tcccggctgt cctacagtcc tcaggactct actccctcag cagcgtggtg      540

accgtgccct ccagcagctt gggcacccag acctacatct gcaacgtgaa tcacaagccc      600

agcaacacca aggtggacgc gagagttgag cccaaatctt gtgacaaaac tcacacatgc      660

ccaccgtgcc cagcacctga actcctgggg ggaccgtcag tcttcctctt ccccccaaaa      720

cccaaggaca ccctcatgat ctcccggacc cctgaggtca catgcgtggt ggtggacgtg      780

agccacgaag accctgaggt caagttcaac tggtacgtgg acggcgtgga ggtgcataat      840

gccaagacaa agccgcggga ggagcagtac gccagcacgt accgtgtggt cagcgtcctc      900

accgtcctgc accaggactg gctgaatggc aaggagtaca agtgcaaggt ctccaacaaa      960

gccctcccag cccccatcga gaaaaccatc tccaaagcca aagggcagcc ccgagaacca     1020

caggtgtaca ccctgccccc atcccgggag gagatgacca agaaccaggt cagcctgacc     1080

tgcctggtca aaggcttcta tcccagcgac atcgccgtgg agtgggagag caatgggcag     1140

ccggagaaca actacaagac cacgcctccc gtgctggact ccgacggctc cttcttcctc     1200

tacagcaagc tcaccgtgga caagagcagg tggcagcagg ggaacgtctt ctcatgctcc     1260

gtgatgcatg aggctctgca caaccactac acgcagaaga gcctctccct gtctccgggt     1320

aaa                                                                   1323


<210>  532
<211>  333
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  532
cagtcggtgg aggagtccgg gggtcgcctg gtaacgcctg ggacacccct gacactcacc       60

tgcacagcct ctggaatcga cctcagtggc tatgcaatgg gctgggtccg ccaggctcca      120

gggaaggggc tggaatggat cggagacatt agtacctatg gtaccacaga ctacgcgagc      180

tgggtgaatg gccgattcac catctccaga acctcgacca cggtgactct gaaaatgacc      240

agtctgacaa ccgaggacac ggccacctat ttctgtgcca gagactattg gttgagcttg      300

tggggcccgg gcaccctcgt caccgtctcg agc                                   333


<210>  533
<211>  87
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  533
cagtcggtgg aggagtccgg gggtcgcctg gtaacgcctg ggacacccct gacactcacc       60

tgcacagcct ctggaatcga cctcagt                                           87


<210>  534
<211>  15
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  534
ggctatgcaa tgggc                                                        15


<210>  535
<211>  42
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  535
tgggtccgcc aggctccagg gaaggggctg gaatggatcg ga                          42


<210>  536
<211>  48
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  536
gacattagta cctatggtac cacagactac gcgagctggg tgaatggc                    48


<210>  537
<211>  90
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  537
cgattcacca tctccagaac ctcgaccacg gtgactctga aaatgaccag tctgacaacc       60

gaggacacgg ccacctattt ctgtgccaga                                        90


<210>  538
<211>  18
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  538
gactattggt tgagcttg                                                     18


<210>  539
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  539
tggggcccgg gcaccctcgt caccgtctcg agc                                    33


<210>  540
<211>  990
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  540
gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg       60

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      240

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacgcgag agttgagccc      300

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      360

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      420

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      480

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacgcc      540

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      600

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc      660

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggaggag      720

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc      780

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg      840

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg      900

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg      960

cagaagagcc tctccctgtc tccgggtaaa                                       990


<210>  541
<211>  218
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  541

Ala Ala Val Leu Thr Gln Thr Pro Ser Pro Val Ser Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Lys Cys Gln Ser Ser Gln Ser Val Tyr Asp Asn 
            20                  25                  30          


Asn Ala Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Ala Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe 
    50                  55                  60                  


Lys Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Asn Gly Val 
65                  70                  75                  80  


Gln Cys Asp Asp Ala Ala Thr Tyr Tyr Cys Leu Gly Gly Tyr Asp Asp 
                85                  90                  95      


Pro Ala Asp Asn Ala Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg 
            100                 105                 110         


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             


<210>  542
<211>  112
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  542

Ala Ala Val Leu Thr Gln Thr Pro Ser Pro Val Ser Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Lys Cys Gln Ser Ser Gln Ser Val Tyr Asp Asn 
            20                  25                  30          


Asn Ala Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Ala Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe 
    50                  55                  60                  


Lys Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Asn Gly Val 
65                  70                  75                  80  


Gln Cys Asp Asp Ala Ala Thr Tyr Tyr Cys Leu Gly Gly Tyr Asp Asp 
                85                  90                  95      


Pro Ala Asp Asn Ala Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg 
            100                 105                 110         


<210>  543
<211>  23
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  543

Ala Ala Val Leu Thr Gln Thr Pro Ser Pro Val Ser Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Lys Cys 
            20              


<210>  544
<211>  13
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  544

Gln Ser Ser Gln Ser Val Tyr Asp Asn Asn Ala Leu Ala 
1               5                   10              


<210>  545
<211>  15
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  545

Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  546
<211>  7
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  546

Ala Ala Ser Thr Leu Ala Ser 
1               5           


<210>  547
<211>  32
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  547

Gly Val Pro Ser Arg Phe Lys Gly Ser Gly Ser Gly Thr Gln Phe Thr 
1               5                   10                  15      


Leu Thr Ile Asn Gly Val Gln Cys Asp Asp Ala Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  548
<211>  11
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  548

Leu Gly Gly Tyr Asp Asp Pro Ala Asp Asn Ala 
1               5                   10      


<210>  549
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  549

Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg 
1               5                   10      


<210>  550
<211>  106
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  550

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105     


<210>  551
<211>  654
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  551
gcagccgtgc tgacccagac accatcgccc gtgtctgcag ctgtgggagg cacagtcacc       60

atcaagtgcc agtccagtca gagtgtttat gataacaatg ctttagcctg gtatcagcag      120

aaaccagggc agcctcccaa gctcctgatc tatgctgcat ccactctggc atctggggtc      180

ccatcgcggt tcaaaggcag tggatctggg acacagttca ctctcaccat caacggcgtg      240

cagtgtgacg atgctgccac ttactactgt ctaggcggtt atgatgatcc tgctgataat      300

gctttcggcg gagggaccga ggtggtggtc aaacgtacgg tagcggcccc atctgtcttc      360

atcttcccgc catctgatga gcagttgaaa tctggaactg cctctgttgt gtgcctgctg      420

aataacttct atcccagaga ggccaaagta cagtggaagg tggataacgc cctccaatcg      480

ggtaactccc aggagagtgt cacagagcag gacagcaagg acagcaccta cagcctcagc      540

agcaccctga cgctgagcaa agcagactac gagaaacaca aagtctacgc ctgcgaagtc      600

acccatcagg gcctgagctc gcccgtcaca aagagcttca acaggggaga gtgt            654


<210>  552
<211>  336
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  552
gcagccgtgc tgacccagac accatcgccc gtgtctgcag ctgtgggagg cacagtcacc       60

atcaagtgcc agtccagtca gagtgtttat gataacaatg ctttagcctg gtatcagcag      120

aaaccagggc agcctcccaa gctcctgatc tatgctgcat ccactctggc atctggggtc      180

ccatcgcggt tcaaaggcag tggatctggg acacagttca ctctcaccat caacggcgtg      240

cagtgtgacg atgctgccac ttactactgt ctaggcggtt atgatgatcc tgctgataat      300

gctttcggcg gagggaccga ggtggtggtc aaacgt                                336


<210>  553
<211>  69
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  553
gcagccgtgc tgacccagac accatcgccc gtgtctgcag ctgtgggagg cacagtcacc       60

atcaagtgc                                                               69


<210>  554
<211>  39
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  554
cagtccagtc agagtgttta tgataacaat gctttagcc                              39


<210>  555
<211>  45
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  555
tggtatcagc agaaaccagg gcagcctccc aagctcctga tctat                       45


<210>  556
<211>  21
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  556
gctgcatcca ctctggcatc t                                                 21


<210>  557
<211>  96
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  557
ggggtcccat cgcggttcaa aggcagtgga tctgggacac agttcactct caccatcaac       60

ggcgtgcagt gtgacgatgc tgccacttac tactgt                                 96


<210>  558
<211>  33
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  558
ctaggcggtt atgatgatcc tgctgataat gct                                    33


<210>  559
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  559
ttcggcggag ggaccgaggt ggtggtcaaa cgt                                    33


<210>  560
<211>  318
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  560
acggtagcgg ccccatctgt cttcatcttc ccgccatctg atgagcagtt gaaatctgga       60

actgcctctg ttgtgtgcct gctgaataac ttctatccca gagaggccaa agtacagtgg      120

aaggtggata acgccctcca atcgggtaac tcccaggaga gtgtcacaga gcaggacagc      180

aaggacagca cctacagcct cagcagcacc ctgacgctga gcaaagcaga ctacgagaaa      240

cacaaagtct acgcctgcga agtcacccat cagggcctga gctcgcccgt cacaaagagc      300

ttcaacaggg gagagtgt                                                    318


<210>  561
<211>  441
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  561

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Ser Leu Ser Arg Tyr Ala 
            20                  25                  30          


Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Asp Ile Ser Thr Tyr Gly Thr Thr Asp Tyr Ala Ser Trp Val Asn Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Arg Thr Ser Thr Thr Val Thr Leu Lys Met Thr 
65                  70                  75                  80  


Ser Leu Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Asp Tyr 
                85                  90                  95      


Trp Leu Ser Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala 
            100                 105                 110         


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
        115                 120                 125             


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
    130                 135                 140                 


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
145                 150                 155                 160 


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
                165                 170                 175     


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
            180                 185                 190         


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Ala Arg 
        195                 200                 205             


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
    210                 215                 220                 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
225                 230                 235                 240 


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
                245                 250                 255     


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
            260                 265                 270         


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
        275                 280                 285             


Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
    290                 295                 300                 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
305                 310                 315                 320 


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
                325                 330                 335     


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
            340                 345                 350         


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
        355                 360                 365             


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
    370                 375                 380                 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
385                 390                 395                 400 


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
                405                 410                 415     


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
            420                 425                 430         


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440     


<210>  562
<211>  111
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  562

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Ser Leu Ser Arg Tyr Ala 
            20                  25                  30          


Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Asp Ile Ser Thr Tyr Gly Thr Thr Asp Tyr Ala Ser Trp Val Asn Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Arg Thr Ser Thr Thr Val Thr Leu Lys Met Thr 
65                  70                  75                  80  


Ser Leu Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Asp Tyr 
                85                  90                  95      


Trp Leu Ser Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            100                 105                 110     


<210>  563
<211>  29
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  563

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Ser Leu Ser 
            20                  25                  


<210>  564
<211>  5
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  564

Arg Tyr Ala Met Gly 
1               5   


<210>  565
<211>  14
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  565

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
1               5                   10                  


<210>  566
<211>  16
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  566

Asp Ile Ser Thr Tyr Gly Thr Thr Asp Tyr Ala Ser Trp Val Asn Gly 
1               5                   10                  15      


<210>  567
<211>  30
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  567

Arg Phe Thr Ile Ser Arg Thr Ser Thr Thr Val Thr Leu Lys Met Thr 
1               5                   10                  15      


Ser Leu Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg 
            20                  25                  30  


<210>  568
<211>  6
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  568

Asp Tyr Trp Leu Ser Leu 
1               5       


<210>  569
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  569

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  570
<211>  330
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  570

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Ala 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  571
<211>  1323
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  571
cagtcggtgg aggagtctgg gggtcgcctg gtcacgcctg ggacacccct gacactcacc       60

tgcacagcct ctggattctc cctcagtaga tatgcaatgg gctgggtccg ccaggctcca      120

gggaaggggc tggaatggat cggagacatt agtacttatg gtaccacaga ctacgcgagc      180

tgggtgaatg gccgattcac catctccaga acctcgacca cggtgactct gaaaatgacc      240

agtctgacaa ccgaggacac ggccacctat ttctgtgcca gagactattg gttgagcttg      300

tggggccaag gcaccctcgt caccgtctcg agcgcctcca ccaagggccc atcggtcttc      360

cccctggcac cctcctccaa gagcacctct gggggcacag cggccctggg ctgcctggtc      420

aaggactact tccccgaacc ggtgacggtg tcgtggaact caggcgccct gaccagcggc      480

gtgcacacct tcccggctgt cctacagtcc tcaggactct actccctcag cagcgtggtg      540

accgtgccct ccagcagctt gggcacccag acctacatct gcaacgtgaa tcacaagccc      600

agcaacacca aggtggacgc gagagttgag cccaaatctt gtgacaaaac tcacacatgc      660

ccaccgtgcc cagcacctga actcctgggg ggaccgtcag tcttcctctt ccccccaaaa      720

cccaaggaca ccctcatgat ctcccggacc cctgaggtca catgcgtggt ggtggacgtg      780

agccacgaag accctgaggt caagttcaac tggtacgtgg acggcgtgga ggtgcataat      840

gccaagacaa agccgcggga ggagcagtac gccagcacgt accgtgtggt cagcgtcctc      900

accgtcctgc accaggactg gctgaatggc aaggagtaca agtgcaaggt ctccaacaaa      960

gccctcccag cccccatcga gaaaaccatc tccaaagcca aagggcagcc ccgagaacca     1020

caggtgtaca ccctgccccc atcccgggag gagatgacca agaaccaggt cagcctgacc     1080

tgcctggtca aaggcttcta tcccagcgac atcgccgtgg agtgggagag caatgggcag     1140

ccggagaaca actacaagac cacgcctccc gtgctggact ccgacggctc cttcttcctc     1200

tacagcaagc tcaccgtgga caagagcagg tggcagcagg ggaacgtctt ctcatgctcc     1260

gtgatgcatg aggctctgca caaccactac acgcagaaga gcctctccct gtctccgggt     1320

aaa                                                                   1323


<210>  572
<211>  333
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  572
cagtcggtgg aggagtctgg gggtcgcctg gtcacgcctg ggacacccct gacactcacc       60

tgcacagcct ctggattctc cctcagtaga tatgcaatgg gctgggtccg ccaggctcca      120

gggaaggggc tggaatggat cggagacatt agtacttatg gtaccacaga ctacgcgagc      180

tgggtgaatg gccgattcac catctccaga acctcgacca cggtgactct gaaaatgacc      240

agtctgacaa ccgaggacac ggccacctat ttctgtgcca gagactattg gttgagcttg      300

tggggccaag gcaccctcgt caccgtctcg agc                                   333


<210>  573
<211>  87
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  573
cagtcggtgg aggagtctgg gggtcgcctg gtcacgcctg ggacacccct gacactcacc       60

tgcacagcct ctggattctc cctcagt                                           87


<210>  574
<211>  15
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  574
agatatgcaa tgggc                                                        15


<210>  575
<211>  42
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  575
tgggtccgcc aggctccagg gaaggggctg gaatggatcg ga                          42


<210>  576
<211>  48
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  576
gacattagta cttatggtac cacagactac gcgagctggg tgaatggc                    48


<210>  577
<211>  90
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  577
cgattcacca tctccagaac ctcgaccacg gtgactctga aaatgaccag tctgacaacc       60

gaggacacgg ccacctattt ctgtgccaga                                        90


<210>  578
<211>  18
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  578
gactattggt tgagcttg                                                     18


<210>  579
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  579
tggggccaag gcaccctcgt caccgtctcg agc                                    33


<210>  580
<211>  990
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  580
gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg       60

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      240

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacgcgag agttgagccc      300

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      360

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      420

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      480

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacgcc      540

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      600

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc      660

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggaggag      720

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc      780

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg      840

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg      900

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg      960

cagaagagcc tctccctgtc tccgggtaaa                                       990


<210>  581
<211>  218
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  581

Ala Ala Val Leu Thr Gln Thr Pro Ser Pro Val Ser Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Lys Cys Gln Ser Ser Gln Ser Val Tyr Asp Asn 
            20                  25                  30          


Asn Ala Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Ala Ala Ser Asn Leu Ala Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Gly Val 
65                  70                  75                  80  


Gln Cys Asp Asp Ala Ala Thr Tyr Tyr Cys Leu Gly Gly Tyr Asp Asp 
                85                  90                  95      


Ala Ala Asp Asn Ala Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg 
            100                 105                 110         


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             


<210>  582
<211>  112
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  582

Ala Ala Val Leu Thr Gln Thr Pro Ser Pro Val Ser Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Lys Cys Gln Ser Ser Gln Ser Val Tyr Asp Asn 
            20                  25                  30          


Asn Ala Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Ala Ala Ser Asn Leu Ala Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Gly Val 
65                  70                  75                  80  


Gln Cys Asp Asp Ala Ala Thr Tyr Tyr Cys Leu Gly Gly Tyr Asp Asp 
                85                  90                  95      


Ala Ala Asp Asn Ala Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg 
            100                 105                 110         


<210>  583
<211>  23
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  583

Ala Ala Val Leu Thr Gln Thr Pro Ser Pro Val Ser Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Lys Cys 
            20              


<210>  584
<211>  13
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  584

Gln Ser Ser Gln Ser Val Tyr Asp Asn Asn Ala Leu Ala 
1               5                   10              


<210>  585
<211>  15
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  585

Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  586
<211>  7
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  586

Ala Ala Ser Asn Leu Ala Ser 
1               5           


<210>  587
<211>  32
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  587

Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Gln Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Gly Val Gln Cys Asp Asp Ala Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  588
<211>  11
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  588

Leu Gly Gly Tyr Asp Asp Ala Ala Asp Asn Ala 
1               5                   10      


<210>  589
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  589

Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg 
1               5                   10      


<210>  590
<211>  106
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  590

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105     


<210>  591
<211>  654
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  591
gcagccgtgc tgacccagac accatcgccc gtgtctgcag ctgtgggagg cacagtcacc       60

atcaagtgcc agtccagtca gagtgtttat gataacaatg ctttagcctg gtatcagcag      120

aaaccaggac agcctcccaa gctcctgatc tatgctgcat ccaatctggc atctggggtc      180

ccagataggt tcagcggcag tggatctggg acacagttca ctctcaccat cagcggcgtg      240

cagtgtgacg atgctgccac ttactactgt ctaggcggtt atgatgatgc tgctgataat      300

gctttcggcg gagggaccga ggtggtggtc aaacgtacgg tagcggcccc atctgtcttc      360

atcttcccgc catctgatga gcagttgaaa tctggaactg cctctgttgt gtgcctgctg      420

aataacttct atcccagaga ggccaaagta cagtggaagg tggataacgc cctccaatcg      480

ggtaactccc aggagagtgt cacagagcag gacagcaagg acagcaccta cagcctcagc      540

agcaccctga cgctgagcaa agcagactac gagaaacaca aagtctacgc ctgcgaagtc      600

acccatcagg gcctgagctc gcccgtcaca aagagcttca acaggggaga gtgt            654


<210>  592
<211>  336
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  592
gcagccgtgc tgacccagac accatcgccc gtgtctgcag ctgtgggagg cacagtcacc       60

atcaagtgcc agtccagtca gagtgtttat gataacaatg ctttagcctg gtatcagcag      120

aaaccaggac agcctcccaa gctcctgatc tatgctgcat ccaatctggc atctggggtc      180

ccagataggt tcagcggcag tggatctggg acacagttca ctctcaccat cagcggcgtg      240

cagtgtgacg atgctgccac ttactactgt ctaggcggtt atgatgatgc tgctgataat      300

gctttcggcg gagggaccga ggtggtggtc aaacgt                                336


<210>  593
<211>  69
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  593
gcagccgtgc tgacccagac accatcgccc gtgtctgcag ctgtgggagg cacagtcacc       60

atcaagtgc                                                               69


<210>  594
<211>  39
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  594
cagtccagtc agagtgttta tgataacaat gctttagcc                              39


<210>  595
<211>  45
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  595
tggtatcagc agaaaccagg acagcctccc aagctcctga tctat                       45


<210>  596
<211>  21
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  596
gctgcatcca atctggcatc t                                                 21


<210>  597
<211>  96
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  597
ggggtcccag ataggttcag cggcagtgga tctgggacac agttcactct caccatcagc       60

ggcgtgcagt gtgacgatgc tgccacttac tactgt                                 96


<210>  598
<211>  33
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  598
ctaggcggtt atgatgatgc tgctgataat gct                                    33


<210>  599
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  599
ttcggcggag ggaccgaggt ggtggtcaaa cgt                                    33


<210>  600
<211>  318
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  600
acggtagcgg ccccatctgt cttcatcttc ccgccatctg atgagcagtt gaaatctgga       60

actgcctctg ttgtgtgcct gctgaataac ttctatccca gagaggccaa agtacagtgg      120

aaggtggata acgccctcca atcgggtaac tcccaggaga gtgtcacaga gcaggacagc      180

aaggacagca cctacagcct cagcagcacc ctgacgctga gcaaagcaga ctacgagaaa      240

cacaaagtct acgcctgcga agtcacccat cagggcctga gctcgcccgt cacaaagagc      300

ttcaacaggg gagagtgt                                                    318


<210>  601
<211>  441
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  601

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Ser Leu Ser Ser Tyr Ala 
            20                  25                  30          


Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Asp Ile Ser Thr Tyr Gly Thr Thr Asp Tyr Ala Ser Trp Val Tyr Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Arg Thr Ser Thr Thr Val Thr Leu Lys Met Thr 
65                  70                  75                  80  


Ser Leu Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Asp Tyr 
                85                  90                  95      


Trp Leu Ser Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala 
            100                 105                 110         


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
        115                 120                 125             


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
    130                 135                 140                 


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
145                 150                 155                 160 


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
                165                 170                 175     


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
            180                 185                 190         


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Ala Arg 
        195                 200                 205             


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
    210                 215                 220                 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
225                 230                 235                 240 


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
                245                 250                 255     


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
            260                 265                 270         


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
        275                 280                 285             


Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
    290                 295                 300                 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
305                 310                 315                 320 


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
                325                 330                 335     


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
            340                 345                 350         


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
        355                 360                 365             


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
    370                 375                 380                 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
385                 390                 395                 400 


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
                405                 410                 415     


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
            420                 425                 430         


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440     


<210>  602
<211>  111
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  602

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Ser Leu Ser Ser Tyr Ala 
            20                  25                  30          


Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Asp Ile Ser Thr Tyr Gly Thr Thr Asp Tyr Ala Ser Trp Val Tyr Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Arg Thr Ser Thr Thr Val Thr Leu Lys Met Thr 
65                  70                  75                  80  


Ser Leu Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Asp Tyr 
                85                  90                  95      


Trp Leu Ser Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            100                 105                 110     


<210>  603
<211>  29
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  603

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Ser Leu Ser 
            20                  25                  


<210>  604
<211>  5
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  604

Ser Tyr Ala Met Gly 
1               5   


<210>  605
<211>  14
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  605

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
1               5                   10                  


<210>  606
<211>  16
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  606

Asp Ile Ser Thr Tyr Gly Thr Thr Asp Tyr Ala Ser Trp Val Tyr Gly 
1               5                   10                  15      


<210>  607
<211>  30
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  607

Arg Phe Thr Ile Ser Arg Thr Ser Thr Thr Val Thr Leu Lys Met Thr 
1               5                   10                  15      


Ser Leu Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg 
            20                  25                  30  


<210>  608
<211>  6
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  608

Asp Tyr Trp Leu Ser Leu 
1               5       


<210>  609
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  609

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  610
<211>  330
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  610

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Ala 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  611
<211>  1323
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  611
cagtcggtgg aggagtccgg gggtcgcctg gtcacgcctg ggacacccct gacactcacc       60

tgcacagcct ctggattctc cctcagtagc tatgcaatgg gctgggtccg ccaggctcca      120

gggaaggggc tggaatggat cggagacatt agtacttatg gtaccacaga ctacgcgagc      180

tgggtgtatg gccgattcac catctccaga acctcgacca cggtgactct gaaaatgacc      240

agtctgacaa ccgaggacac ggccacctat ttctgtgcca gagactattg gttgagcttg      300

tggggccaag gcaccctggt caccgtctcg agcgcctcca ccaagggccc atcggtcttc      360

cccctggcac cctcctccaa gagcacctct gggggcacag cggccctggg ctgcctggtc      420

aaggactact tccccgaacc ggtgacggtg tcgtggaact caggcgccct gaccagcggc      480

gtgcacacct tcccggctgt cctacagtcc tcaggactct actccctcag cagcgtggtg      540

accgtgccct ccagcagctt gggcacccag acctacatct gcaacgtgaa tcacaagccc      600

agcaacacca aggtggacgc gagagttgag cccaaatctt gtgacaaaac tcacacatgc      660

ccaccgtgcc cagcacctga actcctgggg ggaccgtcag tcttcctctt ccccccaaaa      720

cccaaggaca ccctcatgat ctcccggacc cctgaggtca catgcgtggt ggtggacgtg      780

agccacgaag accctgaggt caagttcaac tggtacgtgg acggcgtgga ggtgcataat      840

gccaagacaa agccgcggga ggagcagtac gccagcacgt accgtgtggt cagcgtcctc      900

accgtcctgc accaggactg gctgaatggc aaggagtaca agtgcaaggt ctccaacaaa      960

gccctcccag cccccatcga gaaaaccatc tccaaagcca aagggcagcc ccgagaacca     1020

caggtgtaca ccctgccccc atcccgggag gagatgacca agaaccaggt cagcctgacc     1080

tgcctggtca aaggcttcta tcccagcgac atcgccgtgg agtgggagag caatgggcag     1140

ccggagaaca actacaagac cacgcctccc gtgctggact ccgacggctc cttcttcctc     1200

tacagcaagc tcaccgtgga caagagcagg tggcagcagg ggaacgtctt ctcatgctcc     1260

gtgatgcatg aggctctgca caaccactac acgcagaaga gcctctccct gtctccgggt     1320

aaa                                                                   1323


<210>  612
<211>  333
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  612
cagtcggtgg aggagtccgg gggtcgcctg gtcacgcctg ggacacccct gacactcacc       60

tgcacagcct ctggattctc cctcagtagc tatgcaatgg gctgggtccg ccaggctcca      120

gggaaggggc tggaatggat cggagacatt agtacttatg gtaccacaga ctacgcgagc      180

tgggtgtatg gccgattcac catctccaga acctcgacca cggtgactct gaaaatgacc      240

agtctgacaa ccgaggacac ggccacctat ttctgtgcca gagactattg gttgagcttg      300

tggggccaag gcaccctggt caccgtctcg agc                                   333


<210>  613
<211>  87
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  613
cagtcggtgg aggagtccgg gggtcgcctg gtcacgcctg ggacacccct gacactcacc       60

tgcacagcct ctggattctc cctcagt                                           87


<210>  614
<211>  15
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  614
agctatgcaa tgggc                                                        15


<210>  615
<211>  42
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  615
tgggtccgcc aggctccagg gaaggggctg gaatggatcg ga                          42


<210>  616
<211>  48
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  616
gacattagta cttatggtac cacagactac gcgagctggg tgtatggc                    48


<210>  617
<211>  90
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  617
cgattcacca tctccagaac ctcgaccacg gtgactctga aaatgaccag tctgacaacc       60

gaggacacgg ccacctattt ctgtgccaga                                        90


<210>  618
<211>  18
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  618
gactattggt tgagcttg                                                     18


<210>  619
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  619
tggggccaag gcaccctggt caccgtctcg agc                                    33


<210>  620
<211>  990
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  620
gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg       60

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      240

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacgcgag agttgagccc      300

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      360

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      420

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      480

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacgcc      540

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      600

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc      660

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggaggag      720

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc      780

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg      840

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg      900

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg      960

cagaagagcc tctccctgtc tccgggtaaa                                       990


<210>  621
<211>  218
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  621

Ala Ala Val Leu Thr Gln Thr Pro Ser Pro Val Ser Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Lys Cys Gln Ser Ser Gln Ser Val Tyr Asp Asn 
            20                  25                  30          


Asn Ala Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Ala Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Val 
65                  70                  75                  80  


Gln Cys Asp Asp Ala Ala Thr Tyr Tyr Cys Leu Gly Gly Tyr Tyr Asp 
                85                  90                  95      


Pro Ala Asp Asn Ala Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg 
            100                 105                 110         


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             


<210>  622
<211>  112
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  622

Ala Ala Val Leu Thr Gln Thr Pro Ser Pro Val Ser Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Lys Cys Gln Ser Ser Gln Ser Val Tyr Asp Asn 
            20                  25                  30          


Asn Ala Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Ala Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Val 
65                  70                  75                  80  


Gln Cys Asp Asp Ala Ala Thr Tyr Tyr Cys Leu Gly Gly Tyr Tyr Asp 
                85                  90                  95      


Pro Ala Asp Asn Ala Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg 
            100                 105                 110         


<210>  623
<211>  23
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  623

Ala Ala Val Leu Thr Gln Thr Pro Ser Pro Val Ser Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Lys Cys 
            20              


<210>  624
<211>  13
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  624

Gln Ser Ser Gln Ser Val Tyr Asp Asn Asn Ala Leu Ala 
1               5                   10              


<210>  625
<211>  15
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  625

Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  626
<211>  7
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  626

Ala Ala Ser Thr Leu Ala Ser 
1               5           


<210>  627
<211>  32
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  627

Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Gly Val Gln Cys Asp Asp Ala Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  628
<211>  11
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  628

Leu Gly Gly Tyr Tyr Asp Pro Ala Asp Asn Ala 
1               5                   10      


<210>  629
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  629

Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg 
1               5                   10      


<210>  630
<211>  106
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  630

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105     


<210>  631
<211>  654
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  631
gcagccgtgc tgacccagac accatcgccc gtgtctgcag ctgtgggagg cacagtcacc       60

atcaagtgcc agtccagtca gagtgtttat gataacaatg ctttagcctg gtatcagcag      120

aaaccagggc agcctcccaa gctcctgatc tatgctgcat ccactctggc atctggggtc      180

ccatcgcggt tcagtggcag tggatctggg acagagttca ctctcaccat cagcggcgtg      240

cagtgtgacg atgctgccac ttactactgt ctaggcggtt attatgatcc tgctgataat      300

gctttcggcg gagggaccga ggtggtggtc aaacgtacgg tagcggcccc atctgtcttc      360

atcttcccgc catctgatga gcagttgaaa tctggaactg cctctgttgt gtgcctgctg      420

aataacttct atcccagaga ggccaaagta cagtggaagg tggataacgc cctccaatcg      480

ggtaactccc aggagagtgt cacagagcag gacagcaagg acagcaccta cagcctcagc      540

agcaccctga cgctgagcaa agcagactac gagaaacaca aagtctacgc ctgcgaagtc      600

acccatcagg gcctgagctc gcccgtcaca aagagcttca acaggggaga gtgt            654


<210>  632
<211>  336
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  632
gcagccgtgc tgacccagac accatcgccc gtgtctgcag ctgtgggagg cacagtcacc       60

atcaagtgcc agtccagtca gagtgtttat gataacaatg ctttagcctg gtatcagcag      120

aaaccagggc agcctcccaa gctcctgatc tatgctgcat ccactctggc atctggggtc      180

ccatcgcggt tcagtggcag tggatctggg acagagttca ctctcaccat cagcggcgtg      240

cagtgtgacg atgctgccac ttactactgt ctaggcggtt attatgatcc tgctgataat      300

gctttcggcg gagggaccga ggtggtggtc aaacgt                                336


<210>  633
<211>  69
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  633
gcagccgtgc tgacccagac accatcgccc gtgtctgcag ctgtgggagg cacagtcacc       60

atcaagtgc                                                               69


<210>  634
<211>  39
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  634
cagtccagtc agagtgttta tgataacaat gctttagcc                              39


<210>  635
<211>  45
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  635
tggtatcagc agaaaccagg gcagcctccc aagctcctga tctat                       45


<210>  636
<211>  21
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  636
gctgcatcca ctctggcatc t                                                 21


<210>  637
<211>  96
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  637
ggggtcccat cgcggttcag tggcagtgga tctgggacag agttcactct caccatcagc       60

ggcgtgcagt gtgacgatgc tgccacttac tactgt                                 96


<210>  638
<211>  33
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  638
ctaggcggtt attatgatcc tgctgataat gct                                    33


<210>  639
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  639
ttcggcggag ggaccgaggt ggtggtcaaa cgt                                    33


<210>  640
<211>  318
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  640
acggtagcgg ccccatctgt cttcatcttc ccgccatctg atgagcagtt gaaatctgga       60

actgcctctg ttgtgtgcct gctgaataac ttctatccca gagaggccaa agtacagtgg      120

aaggtggata acgccctcca atcgggtaac tcccaggaga gtgtcacaga gcaggacagc      180

aaggacagca cctacagcct cagcagcacc ctgacgctga gcaaagcaga ctacgagaaa      240

cacaaagtct acgcctgcga agtcacccat cagggcctga gctcgcccgt cacaaagagc      300

ttcaacaggg gagagtgt                                                    318


<210>  641
<211>  451
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  641

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Ser Tyr Asp 
            20                  25                  30          


Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Ile Gly 
        35                  40                  45              


Ile Ile Asn Thr Asn Asp Asp Thr Trp Tyr Ala Ser Trp Val Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr Val Asp Leu Lys Met 
65                  70                  75                  80  


Thr Ser Leu Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Ile 
                85                  90                  95      


Ser Asp Ala Tyr Val Phe Asp Tyr Ala Tyr Tyr Phe Thr Leu Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Ala Arg Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Pro Gly Lys 
    450     


<210>  642
<211>  121
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  642

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Ser Tyr Asp 
            20                  25                  30          


Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Ile Gly 
        35                  40                  45              


Ile Ile Asn Thr Asn Asp Asp Thr Trp Tyr Ala Ser Trp Val Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr Val Asp Leu Lys Met 
65                  70                  75                  80  


Thr Ser Leu Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Ile 
                85                  90                  95      


Ser Asp Ala Tyr Val Phe Asp Tyr Ala Tyr Tyr Phe Thr Leu Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  643
<211>  29
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  643

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser 
            20                  25                  


<210>  644
<211>  5
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  644

Ser Tyr Asp Met Ser 
1               5   


<210>  645
<211>  14
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  645

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Ile Gly 
1               5                   10                  


<210>  646
<211>  16
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  646

Ile Ile Asn Thr Asn Asp Asp Thr Trp Tyr Ala Ser Trp Val Lys Gly 
1               5                   10                  15      


<210>  647
<211>  31
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  647

Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr Val Asp Leu Lys Met 
1               5                   10                  15      


Thr Ser Leu Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg 
            20                  25                  30      


<210>  648
<211>  15
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  648

Ile Ser Asp Ala Tyr Val Phe Asp Tyr Ala Tyr Tyr Phe Thr Leu 
1               5                   10                  15  


<210>  649
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  649

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  650
<211>  330
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  650

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Ala 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  651
<211>  1353
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  651
cagtcggtgg aggagtccgg gggtcgcctg gtcacgcctg ggacacccct gacactcacc       60

tgcaccgtct ctggattctc cctcagcagc tacgacatga gctgggtccg ccaggctcca      120

ggaaaggggc tggaatacat cggcatcatt aatactaatg atgacacatg gtacgcgagc      180

tgggtgaaag gccgattcac catctccaaa acctcgtcga ccacggtgga tctgaaaatg      240

accagtctga caaccgagga cacggccacc tatttctgtg ccagaatatc cgatgcttat      300

gtttttgatt atgcgtatta ctttactttg tggggccagg ggaccctggt caccgtctcg      360

agcgcctcca ccaagggccc atcggtcttc cccctggcac cctcctccaa gagcacctct      420

gggggcacag cggccctggg ctgcctggtc aaggactact tccccgaacc ggtgacggtg      480

tcgtggaact caggcgccct gaccagcggc gtgcacacct tcccggctgt cctacagtcc      540

tcaggactct actccctcag cagcgtggtg accgtgccct ccagcagctt gggcacccag      600

acctacatct gcaacgtgaa tcacaagccc agcaacacca aggtggacgc gagagttgag      660

cccaaatctt gtgacaaaac tcacacatgc ccaccgtgcc cagcacctga actcctgggg      720

ggaccgtcag tcttcctctt ccccccaaaa cccaaggaca ccctcatgat ctcccggacc      780

cctgaggtca catgcgtggt ggtggacgtg agccacgaag accctgaggt caagttcaac      840

tggtacgtgg acggcgtgga ggtgcataat gccaagacaa agccgcggga ggagcagtac      900

gccagcacgt accgtgtggt cagcgtcctc accgtcctgc accaggactg gctgaatggc      960

aaggagtaca agtgcaaggt ctccaacaaa gccctcccag cccccatcga gaaaaccatc     1020

tccaaagcca aagggcagcc ccgagaacca caggtgtaca ccctgccccc atcccgggag     1080

gagatgacca agaaccaggt cagcctgacc tgcctggtca aaggcttcta tcccagcgac     1140

atcgccgtgg agtgggagag caatgggcag ccggagaaca actacaagac cacgcctccc     1200

gtgctggact ccgacggctc cttcttcctc tacagcaagc tcaccgtgga caagagcagg     1260

tggcagcagg ggaacgtctt ctcatgctcc gtgatgcatg aggctctgca caaccactac     1320

acgcagaaga gcctctccct gtctccgggt aaa                                  1353


<210>  652
<211>  363
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  652
cagtcggtgg aggagtccgg gggtcgcctg gtcacgcctg ggacacccct gacactcacc       60

tgcaccgtct ctggattctc cctcagcagc tacgacatga gctgggtccg ccaggctcca      120

ggaaaggggc tggaatacat cggcatcatt aatactaatg atgacacatg gtacgcgagc      180

tgggtgaaag gccgattcac catctccaaa acctcgtcga ccacggtgga tctgaaaatg      240

accagtctga caaccgagga cacggccacc tatttctgtg ccagaatatc cgatgcttat      300

gtttttgatt atgcgtatta ctttactttg tggggccagg ggaccctggt caccgtctcg      360

agc                                                                    363


<210>  653
<211>  87
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  653
cagtcggtgg aggagtccgg gggtcgcctg gtcacgcctg ggacacccct gacactcacc       60

tgcaccgtct ctggattctc cctcagc                                           87


<210>  654
<211>  15
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  654
agctacgaca tgagc                                                        15


<210>  655
<211>  42
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  655
tgggtccgcc aggctccagg aaaggggctg gaatacatcg gc                          42


<210>  656
<211>  48
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  656
atcattaata ctaatgatga cacatggtac gcgagctggg tgaaaggc                    48


<210>  657
<211>  93
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  657
cgattcacca tctccaaaac ctcgtcgacc acggtggatc tgaaaatgac cagtctgaca       60

accgaggaca cggccaccta tttctgtgcc aga                                    93


<210>  658
<211>  45
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  658
atatccgatg cttatgtttt tgattatgcg tattacttta ctttg                       45


<210>  659
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  659
tggggccagg ggaccctggt caccgtctcg agc                                    33


<210>  660
<211>  990
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  660
gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg       60

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      240

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacgcgag agttgagccc      300

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      360

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      420

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      480

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacgcc      540

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      600

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc      660

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggaggag      720

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc      780

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg      840

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg      900

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg      960

cagaagagcc tctccctgtc tccgggtaaa                                       990


<210>  661
<211>  217
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  661

Ala Leu Val Met Thr Gln Thr Pro Ser Ser Val Ser Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Asn Cys Leu Ala Ser Gln Asn Ile Tyr Asn Ser 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Ser Thr Leu Ala Ser Gly Val Ser Ser Arg Phe Lys Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Gly Val Glu Cys 
65                  70                  75                  80  


Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Gly Ala Gly Ala Asp Asn 
                85                  90                  95      


Ile Gly Asn Pro Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg Thr 
            100                 105                 110         


Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
        115                 120                 125             


Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
    130                 135                 140                 


Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
145                 150                 155                 160 


Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
                165                 170                 175     


Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
            180                 185                 190         


Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
        195                 200                 205             


Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215         


<210>  662
<211>  111
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  662

Ala Leu Val Met Thr Gln Thr Pro Ser Ser Val Ser Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Asn Cys Leu Ala Ser Gln Asn Ile Tyr Asn Ser 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Ser Thr Leu Ala Ser Gly Val Ser Ser Arg Phe Lys Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Gly Val Glu Cys 
65                  70                  75                  80  


Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Gly Ala Gly Ala Asp Asn 
                85                  90                  95      


Ile Gly Asn Pro Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg 
            100                 105                 110     


<210>  663
<211>  23
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  663

Ala Leu Val Met Thr Gln Thr Pro Ser Ser Val Ser Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Asn Cys 
            20              


<210>  664
<211>  11
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  664

Leu Ala Ser Gln Asn Ile Tyr Asn Ser Leu Ala 
1               5                   10      


<210>  665
<211>  15
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  665

Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  666
<211>  7
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  666

Arg Ala Ser Thr Leu Ala Ser 
1               5           


<210>  667
<211>  32
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  667

Gly Val Ser Ser Arg Phe Lys Gly Ser Gly Ser Gly Thr Gln Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Gly Val Glu Cys Ala Asp Ala Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  668
<211>  12
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  668

Gln Gln Gly Ala Gly Ala Asp Asn Ile Gly Asn Pro 
1               5                   10          


<210>  669
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  669

Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg 
1               5                   10      


<210>  670
<211>  106
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  670

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105     


<210>  671
<211>  651
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  671
gcccttgtga tgacccagac tccatcctcc gtgtctgcag ctgtgggagg cacagtcacc       60

atcaattgcc tggccagtca gaacatttac aattctttag cctggtatca gcagaaacca      120

gggcagcctc ccaagctcct gatctacagg gcatccactc tggcatctgg ggtctcatcg      180

cggttcaaag gcagtggatc tgggacacag ttcactctca ccatcagcgg cgtggagtgt      240

gccgatgctg ccacttacta ctgtcaacag ggtgctggtg ctgataatat tggtaatcct      300

ttcggcggag ggaccgaggt ggtggtcaaa cgtacggtag cggccccatc tgtcttcatc      360

ttcccgccat ctgatgagca gttgaaatct ggaactgcct ctgttgtgtg cctgctgaat      420

aacttctatc ccagagaggc caaagtacag tggaaggtgg ataacgccct ccaatcgggt      480

aactcccagg agagtgtcac agagcaggac agcaaggaca gcacctacag cctcagcagc      540

accctgacgc tgagcaaagc agactacgag aaacacaaag tctacgcctg cgaagtcacc      600

catcagggcc tgagctcgcc cgtcacaaag agcttcaaca ggggagagtg t               651


<210>  672
<211>  333
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  672
gcccttgtga tgacccagac tccatcctcc gtgtctgcag ctgtgggagg cacagtcacc       60

atcaattgcc tggccagtca gaacatttac aattctttag cctggtatca gcagaaacca      120

gggcagcctc ccaagctcct gatctacagg gcatccactc tggcatctgg ggtctcatcg      180

cggttcaaag gcagtggatc tgggacacag ttcactctca ccatcagcgg cgtggagtgt      240

gccgatgctg ccacttacta ctgtcaacag ggtgctggtg ctgataatat tggtaatcct      300

ttcggcggag ggaccgaggt ggtggtcaaa cgt                                   333


<210>  673
<211>  69
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  673
gcccttgtga tgacccagac tccatcctcc gtgtctgcag ctgtgggagg cacagtcacc       60

atcaattgc                                                               69


<210>  674
<211>  33
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  674
ctggccagtc agaacattta caattcttta gcc                                    33


<210>  675
<211>  45
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  675
tggtatcagc agaaaccagg gcagcctccc aagctcctga tctac                       45


<210>  676
<211>  21
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  676
agggcatcca ctctggcatc t                                                 21


<210>  677
<211>  96
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  677
ggggtctcat cgcggttcaa aggcagtgga tctgggacac agttcactct caccatcagc       60

ggcgtggagt gtgccgatgc tgccacttac tactgt                                 96


<210>  678
<211>  36
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  678
caacagggtg ctggtgctga taatattggt aatcct                                 36


<210>  679
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  679
ttcggcggag ggaccgaggt ggtggtcaaa cgt                                    33


<210>  680
<211>  318
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  680
acggtagcgg ccccatctgt cttcatcttc ccgccatctg atgagcagtt gaaatctgga       60

actgcctctg ttgtgtgcct gctgaataac ttctatccca gagaggccaa agtacagtgg      120

aaggtggata acgccctcca atcgggtaac tcccaggaga gtgtcacaga gcaggacagc      180

aaggacagca cctacagcct cagcagcacc ctgacgctga gcaaagcaga ctacgagaaa      240

cacaaagtct acgcctgcga agtcacccat cagggcctga gctcgcccgt cacaaagagc      300

ttcaacaggg gagagtgt                                                    318


<210>  681
<211>  452
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  681

Gln Glu Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Glu Gly 
1               5                   10                  15      


Ser Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Ser Phe Ser Ser Ser 
            20                  25                  30          


Asp Tyr Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Cys Ile Asp Ala Gly Ser Ser Gly Asp Thr Tyr Phe Ala Ser 
    50                  55                  60                  


Trp Ala Lys Gly Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr Val 
65                  70                  75                  80  


Thr Leu Gln Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe 
                85                  90                  95      


Cys Ala Arg His Leu Tyr Gly Ser Ile Thr Phe Ala Phe Gly Leu Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    130                 135                 140                 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        195                 200                 205             


His Lys Pro Ser Asn Thr Lys Val Asp Ala Arg Val Glu Pro Lys Ser 
    210                 215                 220                 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
225                 230                 235                 240 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                245                 250                 255     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            260                 265                 270         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        275                 280                 285             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr 
    290                 295                 300                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
305                 310                 315                 320 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                325                 330                 335     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            340                 345                 350         


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
        355                 360                 365             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    370                 375                 380                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
385                 390                 395                 400 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                405                 410                 415     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            420                 425                 430         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        435                 440                 445             


Ser Pro Gly Lys 
    450         


<210>  682
<211>  122
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  682

Gln Glu Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Glu Gly 
1               5                   10                  15      


Ser Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Ser Phe Ser Ser Ser 
            20                  25                  30          


Asp Tyr Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Cys Ile Asp Ala Gly Ser Ser Gly Asp Thr Tyr Phe Ala Ser 
    50                  55                  60                  


Trp Ala Lys Gly Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr Val 
65                  70                  75                  80  


Thr Leu Gln Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe 
                85                  90                  95      


Cys Ala Arg His Leu Tyr Gly Ser Ile Thr Phe Ala Phe Gly Leu Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  683
<211>  30
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  683

Gln Glu Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Glu Gly 
1               5                   10                  15      


Ser Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Ser Phe Ser 
            20                  25                  30  


<210>  684
<211>  6
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  684

Ser Ser Asp Tyr Met Cys 
1               5       


<210>  685
<211>  14
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  685

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
1               5                   10                  


<210>  686
<211>  18
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  686

Cys Ile Asp Ala Gly Ser Ser Gly Asp Thr Tyr Phe Ala Ser Trp Ala 
1               5                   10                  15      


Lys Gly 
        


<210>  687
<211>  31
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  687

Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr Val Thr Leu Gln Met 
1               5                   10                  15      


Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys Ala Arg 
            20                  25                  30      


<210>  688
<211>  12
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  688

His Leu Tyr Gly Ser Ile Thr Phe Ala Phe Gly Leu 
1               5                   10          


<210>  689
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  689

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  690
<211>  330
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  690

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Ala 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  691
<211>  1356
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  691
caggagcagc tggtggagtc cgggggaggc ctggtccagc ctgagggatc cctgacactc       60

acctgcacag cctctggatt ctccttcagt agcagcgact acatgtgctg ggtccgccag      120

gctccaggga aggggctgga gtggatcgga tgcattgatg ctggtagtag tggtgacact      180

tacttcgcga gctgggcgaa aggccgattc accatctcca aaacctcgtc gaccacggtg      240

actctgcaaa tgaccagtct gacagccgcg gacacggcca cctatttctg tgcgagacat      300

ctttatggta gtattacttt cgcctttggc ttgtggggcc agggcaccct ggtcaccgtc      360

tcgagcgcct ccaccaaggg cccatcggtc ttccccctgg caccctcctc caagagcacc      420

tctgggggca cagcggccct gggctgcctg gtcaaggact acttccccga accggtgacg      480

gtgtcgtgga actcaggcgc cctgaccagc ggcgtgcaca ccttcccggc tgtcctacag      540

tcctcaggac tctactccct cagcagcgtg gtgaccgtgc cctccagcag cttgggcacc      600

cagacctaca tctgcaacgt gaatcacaag cccagcaaca ccaaggtgga cgcgagagtt      660

gagcccaaat cttgtgacaa aactcacaca tgcccaccgt gcccagcacc tgaactcctg      720

gggggaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg      780

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc      840

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag      900

tacgccagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat      960

ggcaaggagt acaagtgcaa ggtctccaac aaagccctcc cagcccccat cgagaaaacc     1020

atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg     1080

gaggagatga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatcccagc     1140

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct     1200

cccgtgctgg actccgacgg ctccttcttc ctctacagca agctcaccgt ggacaagagc     1260

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac     1320

tacacgcaga agagcctctc cctgtctccg ggtaaa                               1356


<210>  692
<211>  366
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  692
caggagcagc tggtggagtc cgggggaggc ctggtccagc ctgagggatc cctgacactc       60

acctgcacag cctctggatt ctccttcagt agcagcgact acatgtgctg ggtccgccag      120

gctccaggga aggggctgga gtggatcgga tgcattgatg ctggtagtag tggtgacact      180

tacttcgcga gctgggcgaa aggccgattc accatctcca aaacctcgtc gaccacggtg      240

actctgcaaa tgaccagtct gacagccgcg gacacggcca cctatttctg tgcgagacat      300

ctttatggta gtattacttt cgcctttggc ttgtggggcc agggcaccct ggtcaccgtc      360

tcgagc                                                                 366


<210>  693
<211>  90
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  693
caggagcagc tggtggagtc cgggggaggc ctggtccagc ctgagggatc cctgacactc       60

acctgcacag cctctggatt ctccttcagt                                        90


<210>  694
<211>  18
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  694
agcagcgact acatgtgc                                                     18


<210>  695
<211>  42
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  695
tgggtccgcc aggctccagg gaaggggctg gagtggatcg ga                          42


<210>  696
<211>  54
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  696
tgcattgatg ctggtagtag tggtgacact tacttcgcga gctgggcgaa aggc             54


<210>  697
<211>  93
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  697
cgattcacca tctccaaaac ctcgtcgacc acggtgactc tgcaaatgac cagtctgaca       60

gccgcggaca cggccaccta tttctgtgcg aga                                    93


<210>  698
<211>  36
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  698
catctttatg gtagtattac tttcgccttt ggcttg                                 36


<210>  699
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  699
tggggccagg gcaccctggt caccgtctcg agc                                    33


<210>  700
<211>  990
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  700
gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg       60

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      240

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacgcgag agttgagccc      300

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      360

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      420

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      480

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacgcc      540

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      600

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc      660

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggaggag      720

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc      780

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg      840

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg      900

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg      960

cagaagagcc tctccctgtc tccgggtaaa                                       990


<210>  701
<211>  217
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  701

Ala Ala Val Leu Thr Gln Thr Pro Ser Pro Val Ser Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Asn Cys Gln Ala Ser Gln Ser Ile Gly Ser Asp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Gly Val Gln Cys 
65                  70                  75                  80  


Asp Asp Ala Ala Thr Tyr Tyr Cys Gln Gly Thr Tyr Tyr Ser Ser Gly 
                85                  90                  95      


Trp Tyr Thr Ala Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg Thr 
            100                 105                 110         


Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
        115                 120                 125             


Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
    130                 135                 140                 


Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
145                 150                 155                 160 


Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
                165                 170                 175     


Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
            180                 185                 190         


Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
        195                 200                 205             


Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215         


<210>  702
<211>  111
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  702

Ala Ala Val Leu Thr Gln Thr Pro Ser Pro Val Ser Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Asn Cys Gln Ala Ser Gln Ser Ile Gly Ser Asp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Gly Val Gln Cys 
65                  70                  75                  80  


Asp Asp Ala Ala Thr Tyr Tyr Cys Gln Gly Thr Tyr Tyr Ser Ser Gly 
                85                  90                  95      


Trp Tyr Thr Ala Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg 
            100                 105                 110     


<210>  703
<211>  23
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  703

Ala Ala Val Leu Thr Gln Thr Pro Ser Pro Val Ser Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Asn Cys 
            20              


<210>  704
<211>  11
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  704

Gln Ala Ser Gln Ser Ile Gly Ser Asp Leu Ala 
1               5                   10      


<210>  705
<211>  15
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  705

Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  706
<211>  7
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  706

Asp Ala Ser Thr Leu Ala Ser 
1               5           


<210>  707
<211>  32
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  707

Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Gln Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Gly Val Gln Cys Asp Asp Ala Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  708
<211>  12
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  708

Gln Gly Thr Tyr Tyr Ser Ser Gly Trp Tyr Thr Ala 
1               5                   10          


<210>  709
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  709

Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg 
1               5                   10      


<210>  710
<211>  106
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  710

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105     


<210>  711
<211>  651
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  711
gcagccgtgc tgacccagac accatcgccc gtgtctgcag ctgtgggagg cacagtcacc       60

atcaattgcc aggccagtca gagcattggt agcgacttag cctggtatca gcagaaacca      120

gggcagcctc ccaagctcct gatctatgat gcatccactc tggcatctgg ggtcccatcg      180

cggttcagcg gcagtggatc tgggacacag ttcactctca ccatcagcgg cgtgcagtgt      240

gacgatgctg ccacttacta ctgtcaaggc acttattata gtagtggttg gtacactgct      300

ttcggcggag ggaccgaggt ggtggtcaaa cgtacggtag cggccccatc tgtcttcatc      360

ttcccgccat ctgatgagca gttgaaatct ggaactgcct ctgttgtgtg cctgctgaat      420

aacttctatc ccagagaggc caaagtacag tggaaggtgg ataacgccct ccaatcgggt      480

aactcccagg agagtgtcac agagcaggac agcaaggaca gcacctacag cctcagcagc      540

accctgacgc tgagcaaagc agactacgag aaacacaaag tctacgcctg cgaagtcacc      600

catcagggcc tgagctcgcc cgtcacaaag agcttcaaca ggggagagtg t               651


<210>  712
<211>  333
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  712
gcagccgtgc tgacccagac accatcgccc gtgtctgcag ctgtgggagg cacagtcacc       60

atcaattgcc aggccagtca gagcattggt agcgacttag cctggtatca gcagaaacca      120

gggcagcctc ccaagctcct gatctatgat gcatccactc tggcatctgg ggtcccatcg      180

cggttcagcg gcagtggatc tgggacacag ttcactctca ccatcagcgg cgtgcagtgt      240

gacgatgctg ccacttacta ctgtcaaggc acttattata gtagtggttg gtacactgct      300

ttcggcggag ggaccgaggt ggtggtcaaa cgt                                   333


<210>  713
<211>  69
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  713
gcagccgtgc tgacccagac accatcgccc gtgtctgcag ctgtgggagg cacagtcacc       60

atcaattgc                                                               69


<210>  714
<211>  33
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  714
caggccagtc agagcattgg tagcgactta gcc                                    33


<210>  715
<211>  45
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  715
tggtatcagc agaaaccagg gcagcctccc aagctcctga tctat                       45


<210>  716
<211>  21
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  716
gatgcatcca ctctggcatc t                                                 21


<210>  717
<211>  96
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  717
ggggtcccat cgcggttcag cggcagtgga tctgggacac agttcactct caccatcagc       60

ggcgtgcagt gtgacgatgc tgccacttac tactgt                                 96


<210>  718
<211>  36
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  718
caaggcactt attatagtag tggttggtac actgct                                 36


<210>  719
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  719
ttcggcggag ggaccgaggt ggtggtcaaa cgt                                    33


<210>  720
<211>  318
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  720
acggtagcgg ccccatctgt cttcatcttc ccgccatctg atgagcagtt gaaatctgga       60

actgcctctg ttgtgtgcct gctgaataac ttctatccca gagaggccaa agtacagtgg      120

aaggtggata acgccctcca atcgggtaac tcccaggaga gtgtcacaga gcaggacagc      180

aaggacagca cctacagcct cagcagcacc ctgacgctga gcaaagcaga ctacgagaaa      240

cacaaagtct acgcctgcga agtcacccat cagggcctga gctcgcccgt cacaaagagc      300

ttcaacaggg gagagtgt                                                    318


<210>  721
<211>  447
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  721

Gln Gln Leu Glu Gln Ser Gly Gly Gly Ala Glu Gly Gly Leu Val Lys 
1               5                   10                  15      


Pro Gly Gly Ser Leu Glu Leu Cys Cys Lys Ala Ser Gly Phe Ser Leu 
            20                  25                  30          


Ser Ser Thr Tyr Trp Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly 
        35                  40                  45              


Leu Glu Trp Ile Gly Cys Ile Tyr Thr Gly Ser Gly Ser Thr Asp Tyr 
    50                  55                  60                  


Ala Ser Trp Val Asn Gly Gln Phe Thr Leu Ser Arg Asp Ile Asp Gln 
65                  70                  75                  80  


Ser Thr Gly Cys Leu Gln Leu Asn Ser Leu Thr Val Ala Asp Thr Ala 
                85                  90                  95      


Met Tyr Tyr Cys Thr Lys Asn Phe Asp Leu Trp Gly Pro Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Ala Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445         


<210>  722
<211>  117
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  722

Gln Gln Leu Glu Gln Ser Gly Gly Gly Ala Glu Gly Gly Leu Val Lys 
1               5                   10                  15      


Pro Gly Gly Ser Leu Glu Leu Cys Cys Lys Ala Ser Gly Phe Ser Leu 
            20                  25                  30          


Ser Ser Thr Tyr Trp Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly 
        35                  40                  45              


Leu Glu Trp Ile Gly Cys Ile Tyr Thr Gly Ser Gly Ser Thr Asp Tyr 
    50                  55                  60                  


Ala Ser Trp Val Asn Gly Gln Phe Thr Leu Ser Arg Asp Ile Asp Gln 
65                  70                  75                  80  


Ser Thr Gly Cys Leu Gln Leu Asn Ser Leu Thr Val Ala Asp Thr Ala 
                85                  90                  95      


Met Tyr Tyr Cys Thr Lys Asn Phe Asp Leu Trp Gly Pro Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  723
<211>  33
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  723

Gln Gln Leu Glu Gln Ser Gly Gly Gly Ala Glu Gly Gly Leu Val Lys 
1               5                   10                  15      


Pro Gly Gly Ser Leu Glu Leu Cys Cys Lys Ala Ser Gly Phe Ser Leu 
            20                  25                  30          


Ser 
    


<210>  724
<211>  6
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  724

Ser Thr Tyr Trp Met Cys 
1               5       


<210>  725
<211>  14
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  725

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
1               5                   10                  


<210>  726
<211>  17
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  726

Cys Ile Tyr Thr Gly Ser Gly Ser Thr Asp Tyr Ala Ser Trp Val Asn 
1               5                   10                  15      


Gly 
    


<210>  727
<211>  32
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  727

Gln Phe Thr Leu Ser Arg Asp Ile Asp Gln Ser Thr Gly Cys Leu Gln 
1               5                   10                  15      


Leu Asn Ser Leu Thr Val Ala Asp Thr Ala Met Tyr Tyr Cys Thr Lys 
            20                  25                  30          


<210>  728
<211>  4
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  728

Asn Phe Asp Leu 
1               


<210>  729
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  729

Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  730
<211>  330
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  730

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Ala 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  731
<211>  1341
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  731
cagcagctgg agcagtccgg aggaggagcc gaaggaggcc tggtcaagcc tgggggatcc       60

ctggaactct gctgcaaggc ctctggattc tccctcagta gcacctactg gatgtgctgg      120

gtccgccagg ctccagggaa ggggctggag tggattggat gcatttatac tggtagtggt      180

agcacagact acgcgagctg ggtgaatggc caattcactc tctccagaga catcgaccag      240

agcacaggtt gcctacaact gaacagtctg acagtcgcgg acacggccat gtattactgt      300

acgaaaaatt ttgacttgtg gggcccgggc accctggtca ccgtctcgag cgcctccacc      360

aagggcccat cggtcttccc cctggcaccc tcctccaaga gcacctctgg gggcacagcg      420

gccctgggct gcctggtcaa ggactacttc cccgaaccgg tgacggtgtc gtggaactca      480

ggcgccctga ccagcggcgt gcacaccttc ccggctgtcc tacagtcctc aggactctac      540

tccctcagca gcgtggtgac cgtgccctcc agcagcttgg gcacccagac ctacatctgc      600

aacgtgaatc acaagcccag caacaccaag gtggacgcga gagttgagcc caaatcttgt      660

gacaaaactc acacatgccc accgtgccca gcacctgaac tcctgggggg accgtcagtc      720

ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcaca      780

tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca agttcaactg gtacgtggac      840

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacgc cagcacgtac      900

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa ggagtacaag      960

tgcaaggtct ccaacaaagc cctcccagcc cccatcgaga aaaccatctc caaagccaaa     1020

gggcagcccc gagaaccaca ggtgtacacc ctgcccccat cccgggagga gatgaccaag     1080

aaccaggtca gcctgacctg cctggtcaaa ggcttctatc ccagcgacat cgccgtggag     1140

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc     1200

gacggctcct tcttcctcta cagcaagctc accgtggaca agagcaggtg gcagcagggg     1260

aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc     1320

ctctccctgt ctccgggtaa a                                               1341


<210>  732
<211>  351
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  732
cagcagctgg agcagtccgg aggaggagcc gaaggaggcc tggtcaagcc tgggggatcc       60

ctggaactct gctgcaaggc ctctggattc tccctcagta gcacctactg gatgtgctgg      120

gtccgccagg ctccagggaa ggggctggag tggattggat gcatttatac tggtagtggt      180

agcacagact acgcgagctg ggtgaatggc caattcactc tctccagaga catcgaccag      240

agcacaggtt gcctacaact gaacagtctg acagtcgcgg acacggccat gtattactgt      300

acgaaaaatt ttgacttgtg gggcccgggc accctggtca ccgtctcgag c               351


<210>  733
<211>  99
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  733
cagcagctgg agcagtccgg aggaggagcc gaaggaggcc tggtcaagcc tgggggatcc       60

ctggaactct gctgcaaggc ctctggattc tccctcagt                              99


<210>  734
<211>  18
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  734
agcacctact ggatgtgc                                                     18


<210>  735
<211>  42
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  735
tgggtccgcc aggctccagg gaaggggctg gagtggattg ga                          42


<210>  736
<211>  51
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  736
tgcatttata ctggtagtgg tagcacagac tacgcgagct gggtgaatgg c                51


<210>  737
<211>  96
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  737
caattcactc tctccagaga catcgaccag agcacaggtt gcctacaact gaacagtctg       60

acagtcgcgg acacggccat gtattactgt acgaaa                                 96


<210>  738
<211>  12
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  738
aattttgact tg                                                           12


<210>  739
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  739
tggggcccgg gcaccctggt caccgtctcg agc                                    33


<210>  740
<211>  990
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  740
gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg       60

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      240

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacgcgag agttgagccc      300

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      360

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      420

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      480

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacgcc      540

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      600

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc      660

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggaggag      720

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc      780

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg      840

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg      900

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg      960

cagaagagcc tctccctgtc tccgggtaaa                                       990


<210>  741
<211>  220
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  741

Ala Gln Val Leu Thr Gln Thr Pro Ser Ser Val Ser Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Asn Cys Gln Ser Ser Pro Ser Val Tyr Ser Asn 
            20                  25                  30          


Asn Tyr Leu Ser Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro Lys Gly 
        35                  40                  45              


Leu Ile Ala Asp Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe 
    50                  55                  60                  


Lys Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Gly Val 
65                  70                  75                  80  


Gln Cys Asp Asp Ala Ala Ala Tyr Tyr Cys Leu Gly Tyr Tyr Asp Cys 
                85                  90                  95      


Gly Ser Thr Asp Cys His Ala Phe Gly Gly Gly Thr Glu Val Val Val 
            100                 105                 110         


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
        115                 120                 125             


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
    130                 135                 140                 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
145                 150                 155                 160 


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
                165                 170                 175     


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
            180                 185                 190         


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
        195                 200                 205             


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 220 


<210>  742
<211>  114
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  742

Ala Gln Val Leu Thr Gln Thr Pro Ser Ser Val Ser Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Asn Cys Gln Ser Ser Pro Ser Val Tyr Ser Asn 
            20                  25                  30          


Asn Tyr Leu Ser Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro Lys Gly 
        35                  40                  45              


Leu Ile Ala Asp Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe 
    50                  55                  60                  


Lys Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Gly Val 
65                  70                  75                  80  


Gln Cys Asp Asp Ala Ala Ala Tyr Tyr Cys Leu Gly Tyr Tyr Asp Cys 
                85                  90                  95      


Gly Ser Thr Asp Cys His Ala Phe Gly Gly Gly Thr Glu Val Val Val 
            100                 105                 110         


Lys Arg 
        


<210>  743
<211>  23
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  743

Ala Gln Val Leu Thr Gln Thr Pro Ser Ser Val Ser Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Asn Cys 
            20              


<210>  744
<211>  13
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  744

Gln Ser Ser Pro Ser Val Tyr Ser Asn Asn Tyr Leu Ser 
1               5                   10              


<210>  745
<211>  15
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  745

Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro Lys Gly Leu Ile Ala 
1               5                   10                  15  


<210>  746
<211>  7
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  746

Asp Ala Ser Thr Leu Ala Ser 
1               5           


<210>  747
<211>  32
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  747

Gly Val Pro Ser Arg Phe Lys Gly Ser Gly Ser Gly Thr Gln Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Gly Val Gln Cys Asp Asp Ala Ala Ala Tyr Tyr Cys 
            20                  25                  30          


<210>  748
<211>  13
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  748

Leu Gly Tyr Tyr Asp Cys Gly Ser Thr Asp Cys His Ala 
1               5                   10              


<210>  749
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  749

Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg 
1               5                   10      


<210>  750
<211>  106
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  750

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105     


<210>  751
<211>  660
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  751
gcccaagtgc tgacccagac tccatcctcc gtgtctgcag ctgtgggagg cacagtcacc       60

atcaattgcc agtccagtcc gagtgtttat agtaacaact acttatcctg gtttcagcag      120

aaaccagggc agcctcccaa aggcctgatc gctgatgcat ccactctggc atctggggtc      180

ccatcgcggt tcaaaggcag tggatctggg acacagttca ctctcaccat cagcggcgtg      240

cagtgtgacg atgctgccgc ttactactgt ctaggctatt atgattgtgg tagtactgat      300

tgtcatgctt tcggcggagg gaccgaggtg gtggtcaaac gtacggtagc ggccccatct      360

gtcttcatct tcccgccatc tgatgagcag ttgaaatctg gaactgcctc tgttgtgtgc      420

ctgctgaata acttctatcc cagagaggcc aaagtacagt ggaaggtgga taacgccctc      480

caatcgggta actcccagga gagtgtcaca gagcaggaca gcaaggacag cacctacagc      540

ctcagcagca ccctgacgct gagcaaagca gactacgaga aacacaaagt ctacgcctgc      600

gaagtcaccc atcagggcct gagctcgccc gtcacaaaga gcttcaacag gggagagtgt      660


<210>  752
<211>  342
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  752
gcccaagtgc tgacccagac tccatcctcc gtgtctgcag ctgtgggagg cacagtcacc       60

atcaattgcc agtccagtcc gagtgtttat agtaacaact acttatcctg gtttcagcag      120

aaaccagggc agcctcccaa aggcctgatc gctgatgcat ccactctggc atctggggtc      180

ccatcgcggt tcaaaggcag tggatctggg acacagttca ctctcaccat cagcggcgtg      240

cagtgtgacg atgctgccgc ttactactgt ctaggctatt atgattgtgg tagtactgat      300

tgtcatgctt tcggcggagg gaccgaggtg gtggtcaaac gt                         342


<210>  753
<211>  69
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  753
gcccaagtgc tgacccagac tccatcctcc gtgtctgcag ctgtgggagg cacagtcacc       60

atcaattgc                                                               69


<210>  754
<211>  39
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  754
cagtccagtc cgagtgttta tagtaacaac tacttatcc                              39


<210>  755
<211>  45
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  755
tggtttcagc agaaaccagg gcagcctccc aaaggcctga tcgct                       45


<210>  756
<211>  21
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  756
gatgcatcca ctctggcatc t                                                 21


<210>  757
<211>  96
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  757
ggggtcccat cgcggttcaa aggcagtgga tctgggacac agttcactct caccatcagc       60

ggcgtgcagt gtgacgatgc tgccgcttac tactgt                                 96


<210>  758
<211>  39
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  758
ctaggctatt atgattgtgg tagtactgat tgtcatgct                              39


<210>  759
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  759
ttcggcggag ggaccgaggt ggtggtcaaa cgt                                    33


<210>  760
<211>  318
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  760
acggtagcgg ccccatctgt cttcatcttc ccgccatctg atgagcagtt gaaatctgga       60

actgcctctg ttgtgtgcct gctgaataac ttctatccca gagaggccaa agtacagtgg      120

aaggtggata acgccctcca atcgggtaac tcccaggaga gtgtcacaga gcaggacagc      180

aaggacagca cctacagcct cagcagcacc ctgacgctga gcaaagcaga ctacgagaaa      240

cacaaagtct acgcctgcga agtcacccat cagggcctga gctcgcccgt cacaaagagc      300

ttcaacaggg gagagtgt                                                    318


<210>  761
<211>  447
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  761

Gln Gln Leu Glu Gln Ser Gly Gly Gly Ala Glu Gly Gly Leu Val Lys 
1               5                   10                  15      


Pro Gly Gly Ser Leu Glu Leu Cys Cys Lys Ala Ser Gly Phe Ser Leu 
            20                  25                  30          


Thr Thr Ser His Trp Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly 
        35                  40                  45              


Leu Asn Trp Ile Gly Cys Ile Ser Ala Gly Ser Gly Asp Ala Asp Tyr 
    50                  55                  60                  


Ala Thr Trp Val Asp Ala Gln Phe Thr Leu Ser Arg Asp Ile Asp Gln 
65                  70                  75                  80  


Asn Thr Gly Cys Leu Gln Leu Asn Ser Leu Thr Pro Ala Asp Thr Ala 
                85                  90                  95      


Met Tyr Tyr Cys Thr Ile Asn Phe Glu Leu Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Ala Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445         


<210>  762
<211>  117
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  762

Gln Gln Leu Glu Gln Ser Gly Gly Gly Ala Glu Gly Gly Leu Val Lys 
1               5                   10                  15      


Pro Gly Gly Ser Leu Glu Leu Cys Cys Lys Ala Ser Gly Phe Ser Leu 
            20                  25                  30          


Thr Thr Ser His Trp Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly 
        35                  40                  45              


Leu Asn Trp Ile Gly Cys Ile Ser Ala Gly Ser Gly Asp Ala Asp Tyr 
    50                  55                  60                  


Ala Thr Trp Val Asp Ala Gln Phe Thr Leu Ser Arg Asp Ile Asp Gln 
65                  70                  75                  80  


Asn Thr Gly Cys Leu Gln Leu Asn Ser Leu Thr Pro Ala Asp Thr Ala 
                85                  90                  95      


Met Tyr Tyr Cys Thr Ile Asn Phe Glu Leu Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  763
<211>  33
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  763

Gln Gln Leu Glu Gln Ser Gly Gly Gly Ala Glu Gly Gly Leu Val Lys 
1               5                   10                  15      


Pro Gly Gly Ser Leu Glu Leu Cys Cys Lys Ala Ser Gly Phe Ser Leu 
            20                  25                  30          


Thr 
    


<210>  764
<211>  6
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  764

Thr Ser His Trp Met Cys 
1               5       


<210>  765
<211>  14
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  765

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Asn Trp Ile Gly 
1               5                   10                  


<210>  766
<211>  17
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  766

Cys Ile Ser Ala Gly Ser Gly Asp Ala Asp Tyr Ala Thr Trp Val Asp 
1               5                   10                  15      


Ala 
    


<210>  767
<211>  32
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  767

Gln Phe Thr Leu Ser Arg Asp Ile Asp Gln Asn Thr Gly Cys Leu Gln 
1               5                   10                  15      


Leu Asn Ser Leu Thr Pro Ala Asp Thr Ala Met Tyr Tyr Cys Thr Ile 
            20                  25                  30          


<210>  768
<211>  4
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  768

Asn Phe Glu Leu 
1               


<210>  769
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  769

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  770
<211>  330
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  770

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Ala 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  771
<211>  1341
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  771
cagcagctgg agcagtccgg aggaggagcc gaaggaggcc tggtcaagcc tgggggatcc       60

ctggaactct gctgcaaagc ctctggattc tccctcacta cgagccactg gatgtgttgg      120

gtccgccagg ctccagggaa ggggctgaat tggattggat gcattagtgc cggtagtggt      180

gacgcagact acgcgacctg ggtggatgcc caattcactc tctccagaga catcgaccag      240

aacacaggtt gcctacaatt gaacagtctg acacccgcgg acacggccat gtattactgt      300

acgataaatt ttgagttgtg gggccaaggc accctggtca ccgtctcgag cgcctccacc      360

aagggcccat cggtcttccc cctggcaccc tcctccaaga gcacctctgg gggcacagcg      420

gccctgggct gcctggtcaa ggactacttc cccgaaccgg tgacggtgtc gtggaactca      480

ggcgccctga ccagcggcgt gcacaccttc ccggctgtcc tacagtcctc aggactctac      540

tccctcagca gcgtggtgac cgtgccctcc agcagcttgg gcacccagac ctacatctgc      600

aacgtgaatc acaagcccag caacaccaag gtggacgcga gagttgagcc caaatcttgt      660

gacaaaactc acacatgccc accgtgccca gcacctgaac tcctgggggg accgtcagtc      720

ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcaca      780

tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca agttcaactg gtacgtggac      840

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacgc cagcacgtac      900

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa ggagtacaag      960

tgcaaggtct ccaacaaagc cctcccagcc cccatcgaga aaaccatctc caaagccaaa     1020

gggcagcccc gagaaccaca ggtgtacacc ctgcccccat cccgggagga gatgaccaag     1080

aaccaggtca gcctgacctg cctggtcaaa ggcttctatc ccagcgacat cgccgtggag     1140

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc     1200

gacggctcct tcttcctcta cagcaagctc accgtggaca agagcaggtg gcagcagggg     1260

aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc     1320

ctctccctgt ctccgggtaa a                                               1341


<210>  772
<211>  351
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  772
cagcagctgg agcagtccgg aggaggagcc gaaggaggcc tggtcaagcc tgggggatcc       60

ctggaactct gctgcaaagc ctctggattc tccctcacta cgagccactg gatgtgttgg      120

gtccgccagg ctccagggaa ggggctgaat tggattggat gcattagtgc cggtagtggt      180

gacgcagact acgcgacctg ggtggatgcc caattcactc tctccagaga catcgaccag      240

aacacaggtt gcctacaatt gaacagtctg acacccgcgg acacggccat gtattactgt      300

acgataaatt ttgagttgtg gggccaaggc accctggtca ccgtctcgag c               351


<210>  773
<211>  99
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  773
cagcagctgg agcagtccgg aggaggagcc gaaggaggcc tggtcaagcc tgggggatcc       60

ctggaactct gctgcaaagc ctctggattc tccctcact                              99


<210>  774
<211>  18
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  774
acgagccact ggatgtgt                                                     18


<210>  775
<211>  42
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  775
tgggtccgcc aggctccagg gaaggggctg aattggattg ga                          42


<210>  776
<211>  51
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  776
tgcattagtg ccggtagtgg tgacgcagac tacgcgacct gggtggatgc c                51


<210>  777
<211>  96
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  777
caattcactc tctccagaga catcgaccag aacacaggtt gcctacaatt gaacagtctg       60

acacccgcgg acacggccat gtattactgt acgata                                 96


<210>  778
<211>  12
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  778
aattttgagt tg                                                           12


<210>  779
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  779
tggggccaag gcaccctggt caccgtctcg agc                                    33


<210>  780
<211>  990
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  780
gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg       60

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      240

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacgcgag agttgagccc      300

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      360

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      420

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      480

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacgcc      540

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      600

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc      660

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggaggag      720

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc      780

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg      840

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg      900

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg      960

cagaagagcc tctccctgtc tccgggtaaa                                       990


<210>  781
<211>  219
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  781

Ala Gln Val Leu Thr Gln Thr Pro Ser Ser Val Ser Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Asn Cys Gln Ser Ser Pro Ser Val Tyr Ser Ser 
            20                  25                  30          


Tyr Leu Ser Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro Lys Phe Leu 
        35                  40                  45              


Ile Tyr Glu Ala Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Gly Val Gln 
65                  70                  75                  80  


Cys Ser Asp Ala Ala Thr Tyr Tyr Cys Leu Gly Ala Tyr Asp Cys Gly 
                85                  90                  95      


Arg Thr Asp Cys His Ala Phe Gly Gly Gly Thr Glu Val Val Val Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  782
<211>  113
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  782

Ala Gln Val Leu Thr Gln Thr Pro Ser Ser Val Ser Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Asn Cys Gln Ser Ser Pro Ser Val Tyr Ser Ser 
            20                  25                  30          


Tyr Leu Ser Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro Lys Phe Leu 
        35                  40                  45              


Ile Tyr Glu Ala Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Gly Val Gln 
65                  70                  75                  80  


Cys Ser Asp Ala Ala Thr Tyr Tyr Cys Leu Gly Ala Tyr Asp Cys Gly 
                85                  90                  95      


Arg Thr Asp Cys His Ala Phe Gly Gly Gly Thr Glu Val Val Val Lys 
            100                 105                 110         


Arg 
    


<210>  783
<211>  23
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  783

Ala Gln Val Leu Thr Gln Thr Pro Ser Ser Val Ser Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Asn Cys 
            20              


<210>  784
<211>  12
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  784

Gln Ser Ser Pro Ser Val Tyr Ser Ser Tyr Leu Ser 
1               5                   10          


<210>  785
<211>  15
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  785

Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro Lys Phe Leu Ile Tyr 
1               5                   10                  15  


<210>  786
<211>  7
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  786

Glu Ala Ser Lys Leu Ala Ser 
1               5           


<210>  787
<211>  32
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  787

Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Gln Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Gly Val Gln Cys Ser Asp Ala Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  788
<211>  13
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  788

Leu Gly Ala Tyr Asp Cys Gly Arg Thr Asp Cys His Ala 
1               5                   10              


<210>  789
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  789

Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg 
1               5                   10      


<210>  790
<211>  106
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  790

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105     


<210>  791
<211>  657
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  791
gcccaagtgc tgacccagac tccatcctcc gtgtctgcag ctgtgggagg cacagtcacc       60

atcaattgcc agtccagtcc gagtgtttat agtagctact tatcctggtt tcagcagaaa      120

ccagggcagc ctcccaagtt cctgatctac gaagcatcca aactggcatc tggggtccca      180

tcgcggttca gcggcagtgg atctgggaca cagttcactc tcaccatcag cggcgtgcag      240

tgtagcgatg ctgccactta ctactgtctt ggcgcgtatg attgtggtcg tactgattgt      300

catgctttcg gcggagggac cgaggtggtg gtcaaacgta cggtagcggc cccatctgtc      360

ttcatcttcc cgccatctga tgagcagttg aaatctggaa ctgcctctgt tgtgtgcctg      420

ctgaataact tctatcccag agaggccaaa gtacagtgga aggtggataa cgccctccaa      480

tcgggtaact cccaggagag tgtcacagag caggacagca aggacagcac ctacagcctc      540

agcagcaccc tgacgctgag caaagcagac tacgagaaac acaaagtcta cgcctgcgaa      600

gtcacccatc agggcctgag ctcgcccgtc acaaagagct tcaacagggg agagtgt         657


<210>  792
<211>  339
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  792
gcccaagtgc tgacccagac tccatcctcc gtgtctgcag ctgtgggagg cacagtcacc       60

atcaattgcc agtccagtcc gagtgtttat agtagctact tatcctggtt tcagcagaaa      120

ccagggcagc ctcccaagtt cctgatctac gaagcatcca aactggcatc tggggtccca      180

tcgcggttca gcggcagtgg atctgggaca cagttcactc tcaccatcag cggcgtgcag      240

tgtagcgatg ctgccactta ctactgtctt ggcgcgtatg attgtggtcg tactgattgt      300

catgctttcg gcggagggac cgaggtggtg gtcaaacgt                             339


<210>  793
<211>  69
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  793
gcccaagtgc tgacccagac tccatcctcc gtgtctgcag ctgtgggagg cacagtcacc       60

atcaattgc                                                               69


<210>  794
<211>  36
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  794
cagtccagtc cgagtgttta tagtagctac ttatcc                                 36


<210>  795
<211>  45
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  795
tggtttcagc agaaaccagg gcagcctccc aagttcctga tctac                       45


<210>  796
<211>  21
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  796
gaagcatcca aactggcatc t                                                 21


<210>  797
<211>  96
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  797
ggggtcccat cgcggttcag cggcagtgga tctgggacac agttcactct caccatcagc       60

ggcgtgcagt gtagcgatgc tgccacttac tactgt                                 96


<210>  798
<211>  39
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  798
cttggcgcgt atgattgtgg tcgtactgat tgtcatgct                              39


<210>  799
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  799
ttcggcggag ggaccgaggt ggtggtcaaa cgt                                    33


<210>  800
<211>  318
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  800
acggtagcgg ccccatctgt cttcatcttc ccgccatctg atgagcagtt gaaatctgga       60

actgcctctg ttgtgtgcct gctgaataac ttctatccca gagaggccaa agtacagtgg      120

aaggtggata acgccctcca atcgggtaac tcccaggaga gtgtcacaga gcaggacagc      180

aaggacagca cctacagcct cagcagcacc ctgacgctga gcaaagcaga ctacgagaaa      240

cacaaagtct acgcctgcga agtcacccat cagggcctga gctcgcccgt cacaaagagc      300

ttcaacaggg gagagtgt                                                    318


<210>  801
<211>  447
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  801

Gln Gln Leu Glu Gln Ser Gly Gly Gly Ala Glu Gly Gly Leu Val Lys 
1               5                   10                  15      


Pro Gly Gly Ser Leu Lys Leu Ser Cys Lys Ala Ser Gly Phe Thr Ile 
            20                  25                  30          


Ser Arg Asp Tyr Trp Ile Cys Trp Val Arg Gln Ala Pro Gly Lys Gly 
        35                  40                  45              


Leu Glu Trp Ile Gly Cys Ile Ser Ala Gly Gly Gly Ser Thr Asp Tyr 
    50                  55                  60                  


Ala Asn Trp Val Asn Gly Arg Phe Thr Leu Ser Arg Asp Ile Asp Gln 
65                  70                  75                  80  


Ser Thr Gly Cys Leu Gln Leu Asn Ser Leu Thr Asp Ala Asp Thr Ala 
                85                  90                  95      


Met Tyr Tyr Cys Ala Gly Asn Leu Glu Ile Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Ala Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445         


<210>  802
<211>  117
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  802

Gln Gln Leu Glu Gln Ser Gly Gly Gly Ala Glu Gly Gly Leu Val Lys 
1               5                   10                  15      


Pro Gly Gly Ser Leu Lys Leu Ser Cys Lys Ala Ser Gly Phe Thr Ile 
            20                  25                  30          


Ser Arg Asp Tyr Trp Ile Cys Trp Val Arg Gln Ala Pro Gly Lys Gly 
        35                  40                  45              


Leu Glu Trp Ile Gly Cys Ile Ser Ala Gly Gly Gly Ser Thr Asp Tyr 
    50                  55                  60                  


Ala Asn Trp Val Asn Gly Arg Phe Thr Leu Ser Arg Asp Ile Asp Gln 
65                  70                  75                  80  


Ser Thr Gly Cys Leu Gln Leu Asn Ser Leu Thr Asp Ala Asp Thr Ala 
                85                  90                  95      


Met Tyr Tyr Cys Ala Gly Asn Leu Glu Ile Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  803
<211>  33
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  803

Gln Gln Leu Glu Gln Ser Gly Gly Gly Ala Glu Gly Gly Leu Val Lys 
1               5                   10                  15      


Pro Gly Gly Ser Leu Lys Leu Ser Cys Lys Ala Ser Gly Phe Thr Ile 
            20                  25                  30          


Ser 
    


<210>  804
<211>  6
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  804

Arg Asp Tyr Trp Ile Cys 
1               5       


<210>  805
<211>  14
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  805

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
1               5                   10                  


<210>  806
<211>  17
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  806

Cys Ile Ser Ala Gly Gly Gly Ser Thr Asp Tyr Ala Asn Trp Val Asn 
1               5                   10                  15      


Gly 
    


<210>  807
<211>  32
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  807

Arg Phe Thr Leu Ser Arg Asp Ile Asp Gln Ser Thr Gly Cys Leu Gln 
1               5                   10                  15      


Leu Asn Ser Leu Thr Asp Ala Asp Thr Ala Met Tyr Tyr Cys Ala Gly 
            20                  25                  30          


<210>  808
<211>  4
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  808

Asn Leu Glu Ile 
1               


<210>  809
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  809

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  810
<211>  330
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  810

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Ala 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  811
<211>  1341
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  811
cagcagctgg agcagtccgg aggaggagcc gaaggaggcc tggtcaagcc tgggggatcc       60

ctgaaactct cctgcaaagc ctctggattc accatcagta gggactactg gatatgttgg      120

gtccgccagg ctccagggaa ggggctggag tggattggat gcattagtgc tggtggtggt      180

agcacagact acgcgaactg ggtgaatggc cgattcactc tctccagaga catcgaccag      240

agcacaggtt gccttcaact gaacagtctg acagacgcgg acacggccat gtattactgt      300

gcgggaaatc tagagatctg gggccaaggg accctggtca ccgtctcgag cgcctccacc      360

aagggcccat cggtcttccc cctggcaccc tcctccaaga gcacctctgg gggcacagcg      420

gccctgggct gcctggtcaa ggactacttc cccgaaccgg tgacggtgtc gtggaactca      480

ggcgccctga ccagcggcgt gcacaccttc ccggctgtcc tacagtcctc aggactctac      540

tccctcagca gcgtggtgac cgtgccctcc agcagcttgg gcacccagac ctacatctgc      600

aacgtgaatc acaagcccag caacaccaag gtggacgcga gagttgagcc caaatcttgt      660

gacaaaactc acacatgccc accgtgccca gcacctgaac tcctgggggg accgtcagtc      720

ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcaca      780

tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca agttcaactg gtacgtggac      840

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacgc cagcacgtac      900

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa ggagtacaag      960

tgcaaggtct ccaacaaagc cctcccagcc cccatcgaga aaaccatctc caaagccaaa     1020

gggcagcccc gagaaccaca ggtgtacacc ctgcccccat cccgggagga gatgaccaag     1080

aaccaggtca gcctgacctg cctggtcaaa ggcttctatc ccagcgacat cgccgtggag     1140

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc     1200

gacggctcct tcttcctcta cagcaagctc accgtggaca agagcaggtg gcagcagggg     1260

aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc     1320

ctctccctgt ctccgggtaa a                                               1341


<210>  812
<211>  351
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  812
cagcagctgg agcagtccgg aggaggagcc gaaggaggcc tggtcaagcc tgggggatcc       60

ctgaaactct cctgcaaagc ctctggattc accatcagta gggactactg gatatgttgg      120

gtccgccagg ctccagggaa ggggctggag tggattggat gcattagtgc tggtggtggt      180

agcacagact acgcgaactg ggtgaatggc cgattcactc tctccagaga catcgaccag      240

agcacaggtt gccttcaact gaacagtctg acagacgcgg acacggccat gtattactgt      300

gcgggaaatc tagagatctg gggccaaggg accctggtca ccgtctcgag c               351


<210>  813
<211>  99
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  813
cagcagctgg agcagtccgg aggaggagcc gaaggaggcc tggtcaagcc tgggggatcc       60

ctgaaactct cctgcaaagc ctctggattc accatcagt                              99


<210>  814
<211>  18
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  814
agggactact ggatatgt                                                     18


<210>  815
<211>  42
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  815
tgggtccgcc aggctccagg gaaggggctg gagtggattg ga                          42


<210>  816
<211>  51
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  816
tgcattagtg ctggtggtgg tagcacagac tacgcgaact gggtgaatgg c                51


<210>  817
<211>  96
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  817
cgattcactc tctccagaga catcgaccag agcacaggtt gccttcaact gaacagtctg       60

acagacgcgg acacggccat gtattactgt gcggga                                 96


<210>  818
<211>  12
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  818
aatctagaga tc                                                           12


<210>  819
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  819
tggggccaag ggaccctggt caccgtctcg agc                                    33


<210>  820
<211>  990
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  820
gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg       60

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      240

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacgcgag agttgagccc      300

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      360

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      420

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      480

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacgcc      540

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      600

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc      660

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggaggag      720

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc      780

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg      840

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg      900

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg      960

cagaagagcc tctccctgtc tccgggtaaa                                       990


<210>  821
<211>  220
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  821

Ala Gln Val Leu Thr Gln Thr Pro Ser Ser Val Ser Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Asn Cys Gln Ser Ser Pro Ser Ile Tyr Ser Gly 
            20                  25                  30          


Ala Phe Leu Ser Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro Lys Phe 
        35                  40                  45              


Leu Ile Tyr Glu Ala Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Asp Val 
65                  70                  75                  80  


Gln Cys Asp Asp Ala Ala Thr Tyr Tyr Cys Leu Gly Phe Tyr Asp Cys 
                85                  90                  95      


Ser Ser Val Asp Cys His Ala Phe Gly Gly Gly Thr Glu Val Val Val 
            100                 105                 110         


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
        115                 120                 125             


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
    130                 135                 140                 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
145                 150                 155                 160 


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
                165                 170                 175     


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
            180                 185                 190         


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
        195                 200                 205             


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 220 


<210>  822
<211>  114
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  822

Ala Gln Val Leu Thr Gln Thr Pro Ser Ser Val Ser Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Asn Cys Gln Ser Ser Pro Ser Ile Tyr Ser Gly 
            20                  25                  30          


Ala Phe Leu Ser Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro Lys Phe 
        35                  40                  45              


Leu Ile Tyr Glu Ala Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Asp Val 
65                  70                  75                  80  


Gln Cys Asp Asp Ala Ala Thr Tyr Tyr Cys Leu Gly Phe Tyr Asp Cys 
                85                  90                  95      


Ser Ser Val Asp Cys His Ala Phe Gly Gly Gly Thr Glu Val Val Val 
            100                 105                 110         


Lys Arg 
        


<210>  823
<211>  23
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  823

Ala Gln Val Leu Thr Gln Thr Pro Ser Ser Val Ser Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Asn Cys 
            20              


<210>  824
<211>  13
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  824

Gln Ser Ser Pro Ser Ile Tyr Ser Gly Ala Phe Leu Ser 
1               5                   10              


<210>  825
<211>  15
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  825

Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro Lys Phe Leu Ile Tyr 
1               5                   10                  15  


<210>  826
<211>  7
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  826

Glu Ala Ser Lys Leu Ala Ser 
1               5           


<210>  827
<211>  32
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  827

Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Gln Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Asp Val Gln Cys Asp Asp Ala Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  828
<211>  13
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  828

Leu Gly Phe Tyr Asp Cys Ser Ser Val Asp Cys His Ala 
1               5                   10              


<210>  829
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  829

Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg 
1               5                   10      


<210>  830
<211>  106
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  830

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105     


<210>  831
<211>  660
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  831
gcccaagtgc tgacccagac tccatcctcc gtgtctgcag ctgtgggagg cacagtcacc       60

atcaattgcc agtccagtcc gagtatttat agtggcgcct ttttatcctg gtttcagcag      120

aaaccagggc agcctcccaa gttcctgatc tacgaagcct ccaaactggc atctggggtc      180

ccatcgcggt tcagtggcag tggatctggg acacagttca ctctcaccat cagcgacgta      240

cagtgtgacg atgctgccac ttactactgt ctaggctttt atgattgtag cagtgttgat      300

tgccatgctt tcggcggagg gaccgaggtg gtggtcaaac gtacggtagc ggccccatct      360

gtcttcatct tcccgccatc tgatgagcag ttgaaatctg gaactgcctc tgttgtgtgc      420

ctgctgaata acttctatcc cagagaggcc aaagtacagt ggaaggtgga taacgccctc      480

caatcgggta actcccagga gagtgtcaca gagcaggaca gcaaggacag cacctacagc      540

ctcagcagca ccctgacgct gagcaaagca gactacgaga aacacaaagt ctacgcctgc      600

gaagtcaccc atcagggcct gagctcgccc gtcacaaaga gcttcaacag gggagagtgt      660


<210>  832
<211>  342
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  832
gcccaagtgc tgacccagac tccatcctcc gtgtctgcag ctgtgggagg cacagtcacc       60

atcaattgcc agtccagtcc gagtatttat agtggcgcct ttttatcctg gtttcagcag      120

aaaccagggc agcctcccaa gttcctgatc tacgaagcct ccaaactggc atctggggtc      180

ccatcgcggt tcagtggcag tggatctggg acacagttca ctctcaccat cagcgacgta      240

cagtgtgacg atgctgccac ttactactgt ctaggctttt atgattgtag cagtgttgat      300

tgccatgctt tcggcggagg gaccgaggtg gtggtcaaac gt                         342


<210>  833
<211>  69
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  833
gcccaagtgc tgacccagac tccatcctcc gtgtctgcag ctgtgggagg cacagtcacc       60

atcaattgc                                                               69


<210>  834
<211>  39
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  834
cagtccagtc cgagtattta tagtggcgcc tttttatcc                              39


<210>  835
<211>  45
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  835
tggtttcagc agaaaccagg gcagcctccc aagttcctga tctac                       45


<210>  836
<211>  21
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  836
gaagcctcca aactggcatc t                                                 21


<210>  837
<211>  96
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  837
ggggtcccat cgcggttcag tggcagtgga tctgggacac agttcactct caccatcagc       60

gacgtacagt gtgacgatgc tgccacttac tactgt                                 96


<210>  838
<211>  39
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  838
ctaggctttt atgattgtag cagtgttgat tgccatgct                              39


<210>  839
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  839
ttcggcggag ggaccgaggt ggtggtcaaa cgt                                    33


<210>  840
<211>  318
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  840
acggtagcgg ccccatctgt cttcatcttc ccgccatctg atgagcagtt gaaatctgga       60

actgcctctg ttgtgtgcct gctgaataac ttctatccca gagaggccaa agtacagtgg      120

aaggtggata acgccctcca atcgggtaac tcccaggaga gtgtcacaga gcaggacagc      180

aaggacagca cctacagcct cagcagcacc ctgacgctga gcaaagcaga ctacgagaaa      240

cacaaagtct acgcctgcga agtcacccat cagggcctga gctcgcccgt cacaaagagc      300

ttcaacaggg gagagtgt                                                    318


<210>  841

<400>  841
000

<210>  842

<400>  842
000

<210>  843

<400>  843
000

<210>  844

<400>  844
000

<210>  845

<400>  845
000

<210>  846

<400>  846
000

<210>  847

<400>  847
000

<210>  848

<400>  848
000

<210>  849

<400>  849
000

<210>  850

<400>  850
000

<210>  851

<400>  851
000

<210>  852

<400>  852
000

<210>  853

<400>  853
000

<210>  854

<400>  854
000

<210>  855

<400>  855
000

<210>  856

<400>  856
000

<210>  857

<400>  857
000

<210>  858

<400>  858
000

<210>  859

<400>  859
000

<210>  860

<400>  860
000

<210>  861

<400>  861
000

<210>  862

<400>  862
000

<210>  863

<400>  863
000

<210>  864

<400>  864
000

<210>  865

<400>  865
000

<210>  866

<400>  866
000

<210>  867

<400>  867
000

<210>  868

<400>  868
000

<210>  869

<400>  869
000

<210>  870

<400>  870
000

<210>  871

<400>  871
000

<210>  872

<400>  872
000

<210>  873

<400>  873
000

<210>  874

<400>  874
000

<210>  875

<400>  875
000

<210>  876

<400>  876
000

<210>  877

<400>  877
000

<210>  878

<400>  878
000

<210>  879

<400>  879
000

<210>  880

<400>  880
000


<210>  881
<211>  442
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  881

Gln Glu Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Glu Gly 
1               5                   10                  15      


Ser Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Asp Phe Ser Ser Asn 
            20                  25                  30          


Ala Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ser Ile Tyr Asn Ala Asp Gly Lys Asn Tyr Tyr Ala Ile Trp Ala 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Thr Ser Ser Thr Thr Val Thr Leu 
65                  70                  75                  80  


Gln Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys Ala 
                85                  90                  95      


Arg Asp Phe Asp Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            100                 105                 110         


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
        115                 120                 125             


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
    130                 135                 140                 


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
145                 150                 155                 160 


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
                165                 170                 175     


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
            180                 185                 190         


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Ala 
        195                 200                 205             


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
    210                 215                 220                 


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
225                 230                 235                 240 


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
                245                 250                 255     


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
            260                 265                 270         


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
        275                 280                 285             


Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
    290                 295                 300                 


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
305                 310                 315                 320 


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
                325                 330                 335     


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
            340                 345                 350         


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
        355                 360                 365             


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
    370                 375                 380                 


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
385                 390                 395                 400 


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
                405                 410                 415     


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
            420                 425                 430         


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440         


<210>  882
<211>  112
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  882

Gln Glu Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Glu Gly 
1               5                   10                  15      


Ser Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Asp Phe Ser Ser Asn 
            20                  25                  30          


Ala Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ser Ile Tyr Asn Ala Asp Gly Lys Asn Tyr Tyr Ala Ile Trp Ala 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Thr Ser Ser Thr Thr Val Thr Leu 
65                  70                  75                  80  


Gln Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys Ala 
                85                  90                  95      


Arg Asp Phe Asp Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            100                 105                 110         


<210>  883
<211>  30
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  883

Gln Glu Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Glu Gly 
1               5                   10                  15      


Ser Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Asp Phe Ser 
            20                  25                  30  


<210>  884
<211>  5
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  884

Ser Asn Ala Met Cys 
1               5   


<210>  885
<211>  14
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  885

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
1               5                   10                  


<210>  886
<211>  17
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  886

Ser Ile Tyr Asn Ala Asp Gly Lys Asn Tyr Tyr Ala Ile Trp Ala Lys 
1               5                   10                  15      


Gly 
    


<210>  887
<211>  31
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  887

Arg Phe Thr Ile Ser Arg Thr Ser Ser Thr Thr Val Thr Leu Gln Met 
1               5                   10                  15      


Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys Ala Arg 
            20                  25                  30      


<210>  888
<211>  4
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  888

Asp Phe Asp Leu 
1               


<210>  889
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  889

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  890
<211>  330
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  890

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Ala 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  891
<211>  1326
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  891
caggagcagc tggtggagtc cgggggaggc ctggtccagc ctgagggatc cctgacactc       60

acctgcacag cctctggatt cgacttcagt agcaatgcaa tgtgctgggt ccgccaggct      120

ccagggaagg gcctggagtg gatcggatcc atttataatg ctgatggtaa gaattattac      180

gcgatttggg cgaaaggccg attcaccatc tccagaacct cgtcgaccac ggtgactctg      240

caaatgacca gtctgacagc cgcggacacg gccacctatt tctgtgcgag agactttgac      300

ttgtggggcc agggcaccct cgtcaccgtc tcgagcgcct ccaccaaggg cccatcggtc      360

ttccccctgg caccctcctc caagagcacc tctgggggca cagcggccct gggctgcctg      420

gtcaaggact acttccccga accggtgacg gtgtcgtgga actcaggcgc cctgaccagc      480

ggcgtgcaca ccttcccggc tgtcctacag tcctcaggac tctactccct cagcagcgtg      540

gtgaccgtgc cctccagcag cttgggcacc cagacctaca tctgcaacgt gaatcacaag      600

cccagcaaca ccaaggtgga cgcgagagtt gagcccaaat cttgtgacaa aactcacaca      660

tgcccaccgt gcccagcacc tgaactcctg gggggaccgt cagtcttcct cttcccccca      720

aaacccaagg acaccctcat gatctcccgg acccctgagg tcacatgcgt ggtggtggac      780

gtgagccacg aagaccctga ggtcaagttc aactggtacg tggacggcgt ggaggtgcat      840

aatgccaaga caaagccgcg ggaggagcag tacgccagca cgtaccgtgt ggtcagcgtc      900

ctcaccgtcc tgcaccagga ctggctgaat ggcaaggagt acaagtgcaa ggtctccaac      960

aaagccctcc cagcccccat cgagaaaacc atctccaaag ccaaagggca gccccgagaa     1020

ccacaggtgt acaccctgcc cccatcccgg gaggagatga ccaagaacca ggtcagcctg     1080

acctgcctgg tcaaaggctt ctatcccagc gacatcgccg tggagtggga gagcaatggg     1140

cagccggaga acaactacaa gaccacgcct cccgtgctgg actccgacgg ctccttcttc     1200

ctctacagca agctcaccgt ggacaagagc aggtggcagc aggggaacgt cttctcatgc     1260

tccgtgatgc atgaggctct gcacaaccac tacacgcaga agagcctctc cctgtctccg     1320

ggtaaa                                                                1326


<210>  892
<211>  336
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  892
caggagcagc tggtggagtc cgggggaggc ctggtccagc ctgagggatc cctgacactc       60

acctgcacag cctctggatt cgacttcagt agcaatgcaa tgtgctgggt ccgccaggct      120

ccagggaagg gcctggagtg gatcggatcc atttataatg ctgatggtaa gaattattac      180

gcgatttggg cgaaaggccg attcaccatc tccagaacct cgtcgaccac ggtgactctg      240

caaatgacca gtctgacagc cgcggacacg gccacctatt tctgtgcgag agactttgac      300

ttgtggggcc agggcaccct cgtcaccgtc tcgagc                                336


<210>  893
<211>  90
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  893
caggagcagc tggtggagtc cgggggaggc ctggtccagc ctgagggatc cctgacactc       60

acctgcacag cctctggatt cgacttcagt                                        90


<210>  894
<211>  15
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  894
agcaatgcaa tgtgc                                                        15


<210>  895
<211>  42
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  895
tgggtccgcc aggctccagg gaagggcctg gagtggatcg ga                          42


<210>  896
<211>  51
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  896
tccatttata atgctgatgg taagaattat tacgcgattt gggcgaaagg c                51


<210>  897
<211>  93
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  897
cgattcacca tctccagaac ctcgtcgacc acggtgactc tgcaaatgac cagtctgaca       60

gccgcggaca cggccaccta tttctgtgcg aga                                    93


<210>  898
<211>  12
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  898
gactttgact tg                                                           12


<210>  899
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  899
tggggccagg gcaccctcgt caccgtctcg agc                                    33


<210>  900
<211>  990
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  900
gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg       60

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      240

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacgcgag agttgagccc      300

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      360

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      420

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      480

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacgcc      540

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      600

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc      660

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggaggag      720

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc      780

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg      840

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg      900

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg      960

cagaagagcc tctccctgtc tccgggtaaa                                       990


<210>  901
<211>  219
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  901

Ala Ala Val Leu Thr Gln Thr Pro Ser Pro Val Ser Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Asn Cys Gln Ser Ser Gln Ser Val Tyr Asp Asn 
            20                  25                  30          


Asp Trp Leu Ala Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Leu Thr Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Gly Val 
65                  70                  75                  80  


Gln Cys Asp Asp Ala Ala Thr Tyr Tyr Cys Leu Gly Gly Tyr Asp Glu 
                85                  90                  95      


Asp Gly Asp Thr His Val Phe Gly Gly Gly Thr Glu Val Val Val Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  902
<211>  113
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  902

Ala Ala Val Leu Thr Gln Thr Pro Ser Pro Val Ser Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Asn Cys Gln Ser Ser Gln Ser Val Tyr Asp Asn 
            20                  25                  30          


Asp Trp Leu Ala Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Leu Thr Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Gly Val 
65                  70                  75                  80  


Gln Cys Asp Asp Ala Ala Thr Tyr Tyr Cys Leu Gly Gly Tyr Asp Glu 
                85                  90                  95      


Asp Gly Asp Thr His Val Phe Gly Gly Gly Thr Glu Val Val Val Lys 
            100                 105                 110         


Arg 
    


<210>  903
<211>  23
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  903

Ala Ala Val Leu Thr Gln Thr Pro Ser Pro Val Ser Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Asn Cys 
            20              


<210>  904
<211>  13
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  904

Gln Ser Ser Gln Ser Val Tyr Asp Asn Asp Trp Leu Ala 
1               5                   10              


<210>  905
<211>  15
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  905

Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  906
<211>  7
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  906

Leu Thr Ser Thr Leu Ala Ser 
1               5           


<210>  907
<211>  32
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  907

Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Gln Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Gly Val Gln Cys Asp Asp Ala Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  908
<211>  12
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  908

Leu Gly Gly Tyr Asp Glu Asp Gly Asp Thr His Val 
1               5                   10          


<210>  909
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  909

Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg 
1               5                   10      


<210>  910
<211>  106
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  910

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105     


<210>  911
<211>  657
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  911
gcagccgtgc tgacccagac accatcgccc gtgtctgcag ctgtgggagg cacagtcacc       60

atcaattgcc agtccagtca gagtgtttat gataacgact ggttagcctg gttccagcag      120

aaaccagggc agcctcccaa gctcctgatc tatctgacat ccactctggc atctggagtc      180

ccatcgcggt tcagcggcag tggatctggg acacagttca ctctcaccat cagtggtgtg      240

cagtgtgacg atgctgccac ttactactgt ctaggcggct atgatgaaga tggtgatacg      300

catgttttcg gcggagggac cgaggtggtg gtcaaacgta cggtagcggc cccatctgtc      360

ttcatcttcc cgccatctga tgagcagttg aaatctggaa ctgcctctgt tgtgtgcctg      420

ctgaataact tctatcccag agaggccaaa gtacagtgga aggtggataa cgccctccaa      480

tcgggtaact cccaggagag tgtcacagag caggacagca aggacagcac ctacagcctc      540

agcagcaccc tgacgctgag caaagcagac tacgagaaac acaaagtcta cgcctgcgaa      600

gtcacccatc agggcctgag ctcgcccgtc acaaagagct tcaacagggg agagtgt         657


<210>  912
<211>  339
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  912
gcagccgtgc tgacccagac accatcgccc gtgtctgcag ctgtgggagg cacagtcacc       60

atcaattgcc agtccagtca gagtgtttat gataacgact ggttagcctg gttccagcag      120

aaaccagggc agcctcccaa gctcctgatc tatctgacat ccactctggc atctggagtc      180

ccatcgcggt tcagcggcag tggatctggg acacagttca ctctcaccat cagtggtgtg      240

cagtgtgacg atgctgccac ttactactgt ctaggcggct atgatgaaga tggtgatacg      300

catgttttcg gcggagggac cgaggtggtg gtcaaacgt                             339


<210>  913
<211>  69
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  913
gcagccgtgc tgacccagac accatcgccc gtgtctgcag ctgtgggagg cacagtcacc       60

atcaattgc                                                               69


<210>  914
<211>  39
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  914
cagtccagtc agagtgttta tgataacgac tggttagcc                              39


<210>  915
<211>  45
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  915
tggttccagc agaaaccagg gcagcctccc aagctcctga tctat                       45


<210>  916
<211>  21
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  916
ctgacatcca ctctggcatc t                                                 21


<210>  917
<211>  96
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  917
ggagtcccat cgcggttcag cggcagtgga tctgggacac agttcactct caccatcagt       60

ggtgtgcagt gtgacgatgc tgccacttac tactgt                                 96


<210>  918
<211>  36
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  918
ctaggcggct atgatgaaga tggtgatacg catgtt                                 36


<210>  919
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  919
ttcggcggag ggaccgaggt ggtggtcaaa cgt                                    33


<210>  920
<211>  318
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  920
acggtagcgg ccccatctgt cttcatcttc ccgccatctg atgagcagtt gaaatctgga       60

actgcctctg ttgtgtgcct gctgaataac ttctatccca gagaggccaa agtacagtgg      120

aaggtggata acgccctcca atcgggtaac tcccaggaga gtgtcacaga gcaggacagc      180

aaggacagca cctacagcct cagcagcacc ctgacgctga gcaaagcaga ctacgagaaa      240

cacaaagtct acgcctgcga agtcacccat cagggcctga gctcgcccgt cacaaagagc      300

ttcaacaggg gagagtgt                                                    318


<210>  921
<211>  447
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  921

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Asn Asn Tyr Ala 
            20                  25                  30          


Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Ile Met Gly Val Asn Asp Ile Thr Tyr Tyr Ala Ser Trp Ala Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Met Thr 
65                  70                  75                  80  


Ser Leu Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Thr Arg Glu Ile 
                85                  90                  95      


Arg Asp Asp Gly Asp Ser Ser Asp Lys Leu Trp Gly Pro Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Ala Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445         


<210>  922
<211>  117
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  922

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Asn Asn Tyr Ala 
            20                  25                  30          


Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Ile Met Gly Val Asn Asp Ile Thr Tyr Tyr Ala Ser Trp Ala Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Met Thr 
65                  70                  75                  80  


Ser Leu Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Thr Arg Glu Ile 
                85                  90                  95      


Arg Asp Asp Gly Asp Ser Ser Asp Lys Leu Trp Gly Pro Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  923
<211>  29
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  923

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Asn 
            20                  25                  


<210>  924
<211>  5
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  924

Asn Tyr Ala Met Ser 
1               5   


<210>  925
<211>  14
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  925

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
1               5                   10                  


<210>  926
<211>  16
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  926

Ile Met Gly Val Asn Asp Ile Thr Tyr Tyr Ala Ser Trp Ala Lys Gly 
1               5                   10                  15      


<210>  927
<211>  30
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  927

Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Met Thr 
1               5                   10                  15      


Ser Leu Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Thr Arg 
            20                  25                  30  


<210>  928
<211>  12
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  928

Glu Ile Arg Asp Asp Gly Asp Ser Ser Asp Lys Leu 
1               5                   10          


<210>  929
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  929

Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  930
<211>  330
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  930

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Ala 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  931
<211>  1341
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  931
cagtcggtgg aggagtccgg gggtcgcctg gtcacgcctg ggacacccct gacactcacc       60

tgcaccgtct ctggattctc cctcaataac tatgcaatga gctgggtccg ccaggctcca      120

gggaaggggc tggaatggat cggaatcatg ggtgttaatg atatcacata ctacgcgagc      180

tgggcgaaag gccgattcac catctccaaa acctcgacca cggtggatct gaaaatgacc      240

agtctgacaa ccgaggacac ggccacctat ttctgtacta gagagatccg tgatgatggt      300

gatagttctg ataagttgtg gggcccgggc accctcgtca ccgtctcgag cgcctccacc      360

aagggcccat cggtcttccc cctggcaccc tcctccaaga gcacctctgg gggcacagcg      420

gccctgggct gcctggtcaa ggactacttc cccgaaccgg tgacggtgtc gtggaactca      480

ggcgccctga ccagcggcgt gcacaccttc ccggctgtcc tacagtcctc aggactctac      540

tccctcagca gcgtggtgac cgtgccctcc agcagcttgg gcacccagac ctacatctgc      600

aacgtgaatc acaagcccag caacaccaag gtggacgcga gagttgagcc caaatcttgt      660

gacaaaactc acacatgccc accgtgccca gcacctgaac tcctgggggg accgtcagtc      720

ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcaca      780

tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca agttcaactg gtacgtggac      840

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacgc cagcacgtac      900

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa ggagtacaag      960

tgcaaggtct ccaacaaagc cctcccagcc cccatcgaga aaaccatctc caaagccaaa     1020

gggcagcccc gagaaccaca ggtgtacacc ctgcccccat cccgggagga gatgaccaag     1080

aaccaggtca gcctgacctg cctggtcaaa ggcttctatc ccagcgacat cgccgtggag     1140

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc     1200

gacggctcct tcttcctcta cagcaagctc accgtggaca agagcaggtg gcagcagggg     1260

aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc     1320

ctctccctgt ctccgggtaa a                                               1341


<210>  932
<211>  351
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  932
cagtcggtgg aggagtccgg gggtcgcctg gtcacgcctg ggacacccct gacactcacc       60

tgcaccgtct ctggattctc cctcaataac tatgcaatga gctgggtccg ccaggctcca      120

gggaaggggc tggaatggat cggaatcatg ggtgttaatg atatcacata ctacgcgagc      180

tgggcgaaag gccgattcac catctccaaa acctcgacca cggtggatct gaaaatgacc      240

agtctgacaa ccgaggacac ggccacctat ttctgtacta gagagatccg tgatgatggt      300

gatagttctg ataagttgtg gggcccgggc accctcgtca ccgtctcgag c               351


<210>  933
<211>  87
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  933
cagtcggtgg aggagtccgg gggtcgcctg gtcacgcctg ggacacccct gacactcacc       60

tgcaccgtct ctggattctc cctcaat                                           87


<210>  934
<211>  15
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  934
aactatgcaa tgagc                                                        15


<210>  935
<211>  42
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  935
tgggtccgcc aggctccagg gaaggggctg gaatggatcg ga                          42


<210>  936
<211>  48
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  936
atcatgggtg ttaatgatat cacatactac gcgagctggg cgaaaggc                    48


<210>  937
<211>  90
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  937
cgattcacca tctccaaaac ctcgaccacg gtggatctga aaatgaccag tctgacaacc       60

gaggacacgg ccacctattt ctgtactaga                                        90


<210>  938
<211>  36
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  938
gagatccgtg atgatggtga tagttctgat aagttg                                 36


<210>  939
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  939
tggggcccgg gcaccctcgt caccgtctcg agc                                    33


<210>  940
<211>  990
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  940
gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg       60

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      240

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacgcgag agttgagccc      300

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      360

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      420

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      480

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacgcc      540

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      600

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc      660

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggaggag      720

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc      780

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg      840

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg      900

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg      960

cagaagagcc tctccctgtc tccgggtaaa                                       990


<210>  941
<211>  219
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  941

Ala Ile Lys Met Thr Gln Thr Pro Ser Ser Val Ser Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Asn Cys Gln Ala Ser Glu Asp Ile Tyr Thr Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Asn Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asp Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Asp Gly Thr Gln Phe Thr Leu Thr Ile Ser Ala Val Gln Cys 
65                  70                  75                  80  


Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gly Val Ala Trp Ser Ser Asn 
                85                  90                  95      


Thr Gly Tyr Gly Ser Ala Phe Gly Gly Gly Thr Glu Val Val Val Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  942
<211>  113
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  942

Ala Ile Lys Met Thr Gln Thr Pro Ser Ser Val Ser Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Asn Cys Gln Ala Ser Glu Asp Ile Tyr Thr Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Asn Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asp Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Asp Gly Thr Gln Phe Thr Leu Thr Ile Ser Ala Val Gln Cys 
65                  70                  75                  80  


Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gly Val Ala Trp Ser Ser Asn 
                85                  90                  95      


Thr Gly Tyr Gly Ser Ala Phe Gly Gly Gly Thr Glu Val Val Val Lys 
            100                 105                 110         


Arg 
    


<210>  943
<211>  23
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  943

Ala Ile Lys Met Thr Gln Thr Pro Ser Ser Val Ser Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Asn Cys 
            20              


<210>  944
<211>  11
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  944

Gln Ala Ser Glu Asp Ile Tyr Thr Asn Leu Ala 
1               5                   10      


<210>  945
<211>  15
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  945

Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Asn Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  946
<211>  7
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  946

Asp Ala Ser Asp Leu Ala Ser 
1               5           


<210>  947
<211>  32
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  947

Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Asp Gly Thr Gln Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ala Val Gln Cys Glu Asp Ala Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  948
<211>  14
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  948

Gln Gly Val Ala Trp Ser Ser Asn Thr Gly Tyr Gly Ser Ala 
1               5                   10                  


<210>  949
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  949

Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg 
1               5                   10      


<210>  950
<211>  106
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  950

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105     


<210>  951
<211>  657
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  951
gccatcaaaa tgacccagac tccatcctcc gtgtctgcag ctgtgggagg cacagtcacc       60

atcaattgcc aggccagtga ggacatttac accaatttag cctggtatca gcagaaacca      120

gggcagcctc ccaacctcct gatctatgat gcatccgatc tggcatctgg ggtcccgtcg      180

cggttcagcg gcagtggaga tgggacacag ttcactctca ccatcagcgc cgtgcagtgt      240

gaagatgctg ccacttacta ctgtcaaggt gttgcttgga gtagtaatac tggttatggt      300

tccgctttcg gcggagggac cgaggtggtg gtcaaacgta cggtagcggc cccatctgtc      360

ttcatcttcc cgccatctga tgagcagttg aaatctggaa ctgcctctgt tgtgtgcctg      420

ctgaataact tctatcccag agaggccaaa gtacagtgga aggtggataa cgccctccaa      480

tcgggtaact cccaggagag tgtcacagag caggacagca aggacagcac ctacagcctc      540

agcagcaccc tgacgctgag caaagcagac tacgagaaac acaaagtcta cgcctgcgaa      600

gtcacccatc agggcctgag ctcgcccgtc acaaagagct tcaacagggg agagtgt         657


<210>  952
<211>  339
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  952
gccatcaaaa tgacccagac tccatcctcc gtgtctgcag ctgtgggagg cacagtcacc       60

atcaattgcc aggccagtga ggacatttac accaatttag cctggtatca gcagaaacca      120

gggcagcctc ccaacctcct gatctatgat gcatccgatc tggcatctgg ggtcccgtcg      180

cggttcagcg gcagtggaga tgggacacag ttcactctca ccatcagcgc cgtgcagtgt      240

gaagatgctg ccacttacta ctgtcaaggt gttgcttgga gtagtaatac tggttatggt      300

tccgctttcg gcggagggac cgaggtggtg gtcaaacgt                             339


<210>  953
<211>  69
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  953
gccatcaaaa tgacccagac tccatcctcc gtgtctgcag ctgtgggagg cacagtcacc       60

atcaattgc                                                               69


<210>  954
<211>  33
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  954
caggccagtg aggacattta caccaattta gcc                                    33


<210>  955
<211>  45
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  955
tggtatcagc agaaaccagg gcagcctccc aacctcctga tctat                       45


<210>  956
<211>  21
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  956
gatgcatccg atctggcatc t                                                 21


<210>  957
<211>  96
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  957
ggggtcccgt cgcggttcag cggcagtgga gatgggacac agttcactct caccatcagc       60

gccgtgcagt gtgaagatgc tgccacttac tactgt                                 96


<210>  958
<211>  42
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  958
caaggtgttg cttggagtag taatactggt tatggttccg ct                          42


<210>  959
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  959
ttcggcggag ggaccgaggt ggtggtcaaa cgt                                    33


<210>  960
<211>  318
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  960
acggtagcgg ccccatctgt cttcatcttc ccgccatctg atgagcagtt gaaatctgga       60

actgcctctg ttgtgtgcct gctgaataac ttctatccca gagaggccaa agtacagtgg      120

aaggtggata acgccctcca atcgggtaac tcccaggaga gtgtcacaga gcaggacagc      180

aaggacagca cctacagcct cagcagcacc ctgacgctga gcaaagcaga ctacgagaaa      240

cacaaagtct acgcctgcga agtcacccat cagggcctga gctcgcccgt cacaaagagc      300

ttcaacaggg gagagtgt                                                    318


<210>  961

<400>  961
000

<210>  962

<400>  962
000

<210>  963

<400>  963
000

<210>  964

<400>  964
000

<210>  965

<400>  965
000

<210>  966

<400>  966
000

<210>  967

<400>  967
000

<210>  968

<400>  968
000

<210>  969

<400>  969
000

<210>  970

<400>  970
000

<210>  971

<400>  971
000

<210>  972

<400>  972
000

<210>  973

<400>  973
000

<210>  974

<400>  974
000

<210>  975

<400>  975
000

<210>  976

<400>  976
000

<210>  977

<400>  977
000

<210>  978

<400>  978
000

<210>  979

<400>  979
000

<210>  980

<400>  980
000

<210>  981

<400>  981
000

<210>  982

<400>  982
000

<210>  983

<400>  983
000

<210>  984

<400>  984
000

<210>  985

<400>  985
000

<210>  986

<400>  986
000

<210>  987

<400>  987
000

<210>  988

<400>  988
000

<210>  989

<400>  989
000

<210>  990

<400>  990
000

<210>  991

<400>  991
000

<210>  992

<400>  992
000

<210>  993

<400>  993
000

<210>  994

<400>  994
000

<210>  995

<400>  995
000

<210>  996

<400>  996
000

<210>  997

<400>  997
000

<210>  998

<400>  998
000

<210>  999

<400>  999
000

<210>  1000

<400>  1000
000

<210>  1001
<211>  448
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1001

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser Ser Tyr 
            20                  25                  30          


Ala Met Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Ile Ile Tyr Asp Asn Gly Asp Thr Tyr Tyr Ala Ser Ser Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys Ala 
                85                  90                  95      


Arg Glu Pro Gly Ser Thr Thr Gln Asn Asp Leu Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445             


<210>  1002
<211>  118
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1002

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser Ser Tyr 
            20                  25                  30          


Ala Met Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Ile Ile Tyr Asp Asn Gly Asp Thr Tyr Tyr Ala Ser Ser Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys Ala 
                85                  90                  95      


Arg Glu Pro Gly Ser Thr Thr Gln Asn Asp Leu Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  1003
<211>  30
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1003

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser 
            20                  25                  30  


<210>  1004
<211>  5
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  1004

Ser Tyr Ala Met Ile 
1               5   


<210>  1005
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1005

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Gly 
1               5                   10                  


<210>  1006
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1006

Ile Ile Tyr Asp Asn Gly Asp Thr Tyr Tyr Ala Ser Ser Ala Lys Gly 
1               5                   10                  15      


<210>  1007
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1007

Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys Ala Arg 
            20                  25                  30          


<210>  1008
<211>  10
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  1008

Glu Pro Gly Ser Thr Thr Gln Asn Asp Leu 
1               5                   10  


<210>  1009
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1009

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  1010
<211>  330
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1010

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  1011
<211>  1344
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1011
gaggtgcagc ttgtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt ctccctcagt agctatgcga tgatctgggt ccgtcaggct      120

ccagggaagg ggctggagtg ggtcggaatc atttatgata atggtgacac atactacgcg      180

agctctgcga aaggccgatt caccatctcc agagacaatt ccaagaacac cgtgtatctt      240

caaatgaaca gcctgagagc tgaggacact gctgtgtatt tctgtgctag agagcctggt      300

agtactactc agaatgactt gtggggccaa gggaccctcg tcaccgtctc gagcgcctcc      360

accaagggcc catcggtctt ccccctggca ccctcctcca agagcacctc tgggggcaca      420

gcggccctgg gctgcctggt caaggactac ttccccgaac cggtgacggt gtcgtggaac      480

tcaggcgccc tgaccagcgg cgtgcacacc ttcccggctg tcctacagtc ctcaggactc      540

tactccctca gcagcgtggt gaccgtgccc tccagcagct tgggcaccca gacctacatc      600

tgcaacgtga atcacaagcc cagcaacacc aaggtggaca agaaagttga gcccaaatct      660

tgtgacaaaa ctcacacatg cccaccgtgc ccagcacctg aactcctggg gggaccgtca      720

gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc      780

acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg      840

gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta cgccagcacg      900

taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg caaggagtac      960

aagtgcaagg tctccaacaa agccctccca gcccccatcg agaaaaccat ctccaaagcc     1020

aaagggcagc cccgagaacc acaggtgtac accctgcccc catcccggga ggagatgacc     1080

aagaaccagg tcagcctgac ctgcctggtc aaaggcttct atcccagcga catcgccgtg     1140

gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac     1200

tccgacggct ccttcttcct ctacagcaag ctcaccgtgg acaagagcag gtggcagcag     1260

gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag     1320

agcctctccc tgtctccggg taaa                                            1344


<210>  1012
<211>  354
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1012
gaggtgcagc ttgtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt ctccctcagt agctatgcga tgatctgggt ccgtcaggct      120

ccagggaagg ggctggagtg ggtcggaatc atttatgata atggtgacac atactacgcg      180

agctctgcga aaggccgatt caccatctcc agagacaatt ccaagaacac cgtgtatctt      240

caaatgaaca gcctgagagc tgaggacact gctgtgtatt tctgtgctag agagcctggt      300

agtactactc agaatgactt gtggggccaa gggaccctcg tcaccgtctc gagc            354


<210>  1013
<211>  90
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1013
gaggtgcagc ttgtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt ctccctcagt                                        90


<210>  1014
<211>  15
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  1014
agctatgcga tgatc                                                        15


<210>  1015
<211>  42
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1015
tgggtccgtc aggctccagg gaaggggctg gagtgggtcg ga                          42


<210>  1016
<211>  48
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1016
atcatttatg ataatggtga cacatactac gcgagctctg cgaaaggc                    48


<210>  1017
<211>  96
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1017
cgattcacca tctccagaga caattccaag aacaccgtgt atcttcaaat gaacagcctg       60

agagctgagg acactgctgt gtatttctgt gctaga                                 96


<210>  1018
<211>  30
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  1018
gagcctggta gtactactca gaatgacttg                                        30


<210>  1019
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1019
tggggccaag ggaccctcgt caccgtctcg agc                                    33


<210>  1020
<211>  990
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1020
gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg       60

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      240

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttgagccc      300

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      360

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      420

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      480

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacgcc      540

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      600

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc      660

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggaggag      720

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc      780

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg      840

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg      900

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg      960

cagaagagcc tctccctgtc tccgggtaaa                                       990


<210>  1021
<211>  217
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1021

Asp Val Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Glu Asn Ile Tyr Asn Ser 
            20                  25                  30          


Leu Leu Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Asn Tyr Tyr Asn Ile Trp Thr 
                85                  90                  95      


Asn Gly Ala Ala Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105                 110         


Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
        115                 120                 125             


Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
    130                 135                 140                 


Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
145                 150                 155                 160 


Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
                165                 170                 175     


Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
            180                 185                 190         


Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
        195                 200                 205             


Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215         


<210>  1022
<211>  111
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1022

Asp Val Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Glu Asn Ile Tyr Asn Ser 
            20                  25                  30          


Leu Leu Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Asn Tyr Tyr Asn Ile Trp Thr 
                85                  90                  95      


Asn Gly Ala Ala Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110     


<210>  1023
<211>  23
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1023

Asp Val Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys 
            20              


<210>  1024
<211>  11
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  1024

Gln Ala Ser Glu Asn Ile Tyr Asn Ser Leu Leu 
1               5                   10      


<210>  1025
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1025

Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  1026
<211>  7
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  1026

Arg Ala Ser Thr Leu Ala Ser 
1               5           


<210>  1027
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1027

Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  1028
<211>  12
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  1028

Gln Asn Tyr Tyr Asn Ile Trp Thr Asn Gly Ala Ala 
1               5                   10          


<210>  1029
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1029

Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
1               5                   10      


<210>  1030
<211>  106
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1030

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105     


<210>  1031
<211>  651
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1031
gacgttcaga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgtc aggccagtga gaacatttac aactctttac tctggtatca gcagaaacca      120

ggaaaagccc ctaagctcct gatctatagg gcatccactc tggcatctgg agtcccatca      180

aggttcagcg gcagtggatc tggaacagaa ttcactctca ccatcagcag cctgcagcct      240

gatgattttg caacttacta ctgtcaaaac tattataata tatggactaa tggtgctgct      300

ttcggcggag gaaccaaggt ggaaatcaaa cgtacggtag cggccccatc tgtcttcatc      360

ttcccgccat ctgatgagca gttgaaatct ggaactgcct ctgttgtgtg cctgctgaat      420

aacttctatc ccagagaggc caaagtacag tggaaggtgg ataacgccct ccaatcgggt      480

aactcccagg agagtgtcac agagcaggac agcaaggaca gcacctacag cctcagcagc      540

accctgacgc tgagcaaagc agactacgag aaacacaaag tctacgcctg cgaagtcacc      600

catcagggcc tgagctcgcc cgtcacaaag agcttcaaca ggggagagtg t               651


<210>  1032
<211>  333
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1032
gacgttcaga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgtc aggccagtga gaacatttac aactctttac tctggtatca gcagaaacca      120

ggaaaagccc ctaagctcct gatctatagg gcatccactc tggcatctgg agtcccatca      180

aggttcagcg gcagtggatc tggaacagaa ttcactctca ccatcagcag cctgcagcct      240

gatgattttg caacttacta ctgtcaaaac tattataata tatggactaa tggtgctgct      300

ttcggcggag gaaccaaggt ggaaatcaaa cgt                                   333


<210>  1033
<211>  69
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1033
gacgttcaga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgt                                                               69


<210>  1034
<211>  33
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  1034
caggccagtg agaacattta caactcttta ctc                                    33


<210>  1035
<211>  45
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1035
tggtatcagc agaaaccagg aaaagcccct aagctcctga tctat                       45


<210>  1036
<211>  21
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  1036
agggcatcca ctctggcatc t                                                 21


<210>  1037
<211>  96
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1037
ggagtcccat caaggttcag cggcagtgga tctggaacag aattcactct caccatcagc       60

agcctgcagc ctgatgattt tgcaacttac tactgt                                 96


<210>  1038
<211>  36
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  1038
caaaactatt ataatatatg gactaatggt gctgct                                 36


<210>  1039
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1039
ttcggcggag gaaccaaggt ggaaatcaaa cgt                                    33


<210>  1040
<211>  318
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1040
acggtagcgg ccccatctgt cttcatcttc ccgccatctg atgagcagtt gaaatctgga       60

actgcctctg ttgtgtgcct gctgaataac ttctatccca gagaggccaa agtacagtgg      120

aaggtggata acgccctcca atcgggtaac tcccaggaga gtgtcacaga gcaggacagc      180

aaggacagca cctacagcct cagcagcacc ctgacgctga gcaaagcaga ctacgagaaa      240

cacaaagtct acgcctgcga agtcacccat cagggcctga gctcgcccgt cacaaagagc      300

ttcaacaggg gagagtgt                                                    318


<210>  1041
<211>  444
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1041

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser Ser Tyr 
            20                  25                  30          


Ala Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Ile Ser Thr Tyr Gly Thr Thr Asp Tyr Ala Ser Trp Val Tyr 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys Ala 
                85                  90                  95      


Arg Asp Tyr Trp Leu Ser Leu Trp Gly Gln Gly Thr Leu Val Thr Val 
            100                 105                 110         


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
        115                 120                 125             


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
    130                 135                 140                 


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
145                 150                 155                 160 


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
                165                 170                 175     


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
            180                 185                 190         


Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
        195                 200                 205             


Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
    210                 215                 220                 


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
225                 230                 235                 240 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                245                 250                 255     


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
            260                 265                 270         


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        275                 280                 285             


Arg Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
    290                 295                 300                 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
305                 310                 315                 320 


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
                325                 330                 335     


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
            340                 345                 350         


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
        355                 360                 365             


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
    370                 375                 380                 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
385                 390                 395                 400 


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
                405                 410                 415     


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            420                 425                 430         


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 


<210>  1042
<211>  114
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1042

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser Ser Tyr 
            20                  25                  30          


Ala Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Ile Ser Thr Tyr Gly Thr Thr Asp Tyr Ala Ser Trp Val Tyr 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys Ala 
                85                  90                  95      


Arg Asp Tyr Trp Leu Ser Leu Trp Gly Gln Gly Thr Leu Val Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  1043
<211>  30
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1043

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser 
            20                  25                  30  


<210>  1044
<211>  5
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  1044

Ser Tyr Ala Met Gly 
1               5   


<210>  1045
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1045

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
1               5                   10                  


<210>  1046
<211>  16
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  1046

Asp Ile Ser Thr Tyr Gly Thr Thr Asp Tyr Ala Ser Trp Val Tyr Gly 
1               5                   10                  15      


<210>  1047
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1047

Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys Ala Arg 
            20                  25                  30          


<210>  1048
<211>  6
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  1048

Asp Tyr Trp Leu Ser Leu 
1               5       


<210>  1049
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1049

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  1050
<211>  330
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1050

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  1051
<211>  1332
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1051
gaggtgcagc ttgtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt ctccctcagt agctatgcaa tgggctgggt ccgtcaggct      120

ccagggaagg ggctggagtg gatcggagac attagtactt atggtaccac agactacgcg      180

agctgggtgt atggccgatt caccatctcc agagacaatt ccaagaacac cgtgtatctt      240

caaatgaaca gcctgagagc tgaggacact gctgtgtatt tctgtgctag agactattgg      300

ttgagcttgt ggggccaagg gaccctcgtc accgtctcga gcgcctccac caagggccca      360

tcggtcttcc ccctggcacc ctcctccaag agcacctctg ggggcacagc ggccctgggc      420

tgcctggtca aggactactt ccccgaaccg gtgacggtgt cgtggaactc aggcgccctg      480

accagcggcg tgcacacctt cccggctgtc ctacagtcct caggactcta ctccctcagc      540

agcgtggtga ccgtgccctc cagcagcttg ggcacccaga cctacatctg caacgtgaat      600

cacaagccca gcaacaccaa ggtggacaag aaagttgagc ccaaatcttg tgacaaaact      660

cacacatgcc caccgtgccc agcacctgaa ctcctggggg gaccgtcagt cttcctcttc      720

cccccaaaac ccaaggacac cctcatgatc tcccggaccc ctgaggtcac atgcgtggtg      780

gtggacgtga gccacgaaga ccctgaggtc aagttcaact ggtacgtgga cggcgtggag      840

gtgcataatg ccaagacaaa gccgcgggag gagcagtacg ccagcacgta ccgtgtggtc      900

agcgtcctca ccgtcctgca ccaggactgg ctgaatggca aggagtacaa gtgcaaggtc      960

tccaacaaag ccctcccagc ccccatcgag aaaaccatct ccaaagccaa agggcagccc     1020

cgagaaccac aggtgtacac cctgccccca tcccgggagg agatgaccaa gaaccaggtc     1080

agcctgacct gcctggtcaa aggcttctat cccagcgaca tcgccgtgga gtgggagagc     1140

aatgggcagc cggagaacaa ctacaagacc acgcctcccg tgctggactc cgacggctcc     1200

ttcttcctct acagcaagct caccgtggac aagagcaggt ggcagcaggg gaacgtcttc     1260

tcatgctccg tgatgcatga ggctctgcac aaccactaca cgcagaagag cctctccctg     1320

tctccgggta aa                                                         1332


<210>  1052
<211>  342
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1052
gaggtgcagc ttgtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt ctccctcagt agctatgcaa tgggctgggt ccgtcaggct      120

ccagggaagg ggctggagtg gatcggagac attagtactt atggtaccac agactacgcg      180

agctgggtgt atggccgatt caccatctcc agagacaatt ccaagaacac cgtgtatctt      240

caaatgaaca gcctgagagc tgaggacact gctgtgtatt tctgtgctag agactattgg      300

ttgagcttgt ggggccaagg gaccctcgtc accgtctcga gc                         342


<210>  1053
<211>  90
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1053
gaggtgcagc ttgtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt ctccctcagt                                        90


<210>  1054
<211>  15
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  1054
agctatgcaa tgggc                                                        15


<210>  1055
<211>  42
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1055
tgggtccgtc aggctccagg gaaggggctg gagtggatcg ga                          42


<210>  1056
<211>  48
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  1056
gacattagta cttatggtac cacagactac gcgagctggg tgtatggc                    48


<210>  1057
<211>  96
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1057
cgattcacca tctccagaga caattccaag aacaccgtgt atcttcaaat gaacagcctg       60

agagctgagg acactgctgt gtatttctgt gctaga                                 96


<210>  1058
<211>  18
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  1058
gactattggt tgagcttg                                                     18


<210>  1059
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1059
tggggccaag ggaccctcgt caccgtctcg agc                                    33


<210>  1060
<211>  990
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1060
gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg       60

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      240

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttgagccc      300

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      360

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      420

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      480

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacgcc      540

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      600

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc      660

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggaggag      720

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc      780

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg      840

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg      900

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg      960

cagaagagcc tctccctgtc tccgggtaaa                                       990


<210>  1061
<211>  218
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1061

Ala Ala Gln Leu Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ser Ser Gln Ser Val Tyr Asp Asn 
            20                  25                  30          


Asn Ala Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Ala Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu 
65                  70                  75                  80  


Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Leu Gly Gly Tyr Tyr Asp 
                85                  90                  95      


Pro Ala Asp Asn Ala Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110         


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             


<210>  1062
<211>  112
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1062

Ala Ala Gln Leu Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ser Ser Gln Ser Val Tyr Asp Asn 
            20                  25                  30          


Asn Ala Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Ala Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu 
65                  70                  75                  80  


Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Leu Gly Gly Tyr Tyr Asp 
                85                  90                  95      


Pro Ala Asp Asn Ala Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110         


<210>  1063
<211>  23
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1063

Ala Ala Gln Leu Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys 
            20              


<210>  1064
<211>  13
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  1064

Gln Ser Ser Gln Ser Val Tyr Asp Asn Asn Ala Leu Ala 
1               5                   10              


<210>  1065
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1065

Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  1066
<211>  7
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  1066

Ala Ala Ser Thr Leu Ala Ser 
1               5           


<210>  1067
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1067

Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  1068
<211>  11
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  1068

Leu Gly Gly Tyr Tyr Asp Pro Ala Asp Asn Ala 
1               5                   10      


<210>  1069
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1069

Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
1               5                   10      


<210>  1070
<211>  106
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1070

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105     


<210>  1071
<211>  654
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1071
gcagcccagc tgacccagtc tccttccacc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgtc agtccagtca gagtgtttat gataacaatg ctttagcctg gtatcagcag      120

aaaccaggaa aagcccctaa gctcctgatc tatgctgcat ccactctggc atctggagtc      180

ccatcaaggt tcagcggcag tggatctgga acagaattca ctctcaccat cagcagcctg      240

cagcctgatg attttgcaac ttactactgt ctaggcggtt attatgatcc tgctgataat      300

gctttcggcg gaggaaccaa ggtggaaatc aaacgtacgg tagcggcccc atctgtcttc      360

atcttcccgc catctgatga gcagttgaaa tctggaactg cctctgttgt gtgcctgctg      420

aataacttct atcccagaga ggccaaagta cagtggaagg tggataacgc cctccaatcg      480

ggtaactccc aggagagtgt cacagagcag gacagcaagg acagcaccta cagcctcagc      540

agcaccctga cgctgagcaa agcagactac gagaaacaca aagtctacgc ctgcgaagtc      600

acccatcagg gcctgagctc gcccgtcaca aagagcttca acaggggaga gtgt            654


<210>  1072
<211>  336
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1072
gcagcccagc tgacccagtc tccttccacc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgtc agtccagtca gagtgtttat gataacaatg ctttagcctg gtatcagcag      120

aaaccaggaa aagcccctaa gctcctgatc tatgctgcat ccactctggc atctggagtc      180

ccatcaaggt tcagcggcag tggatctgga acagaattca ctctcaccat cagcagcctg      240

cagcctgatg attttgcaac ttactactgt ctaggcggtt attatgatcc tgctgataat      300

gctttcggcg gaggaaccaa ggtggaaatc aaacgt                                336


<210>  1073
<211>  69
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1073
gcagcccagc tgacccagtc tccttccacc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgt                                                               69


<210>  1074
<211>  39
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  1074
cagtccagtc agagtgttta tgataacaat gctttagcc                              39


<210>  1075
<211>  45
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1075
tggtatcagc agaaaccagg aaaagcccct aagctcctga tctat                       45


<210>  1076
<211>  21
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  1076
gctgcatcca ctctggcatc t                                                 21


<210>  1077
<211>  96
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1077
ggagtcccat caaggttcag cggcagtgga tctggaacag aattcactct caccatcagc       60

agcctgcagc ctgatgattt tgcaacttac tactgt                                 96


<210>  1078
<211>  33
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  1078
ctaggcggtt attatgatcc tgctgataat gct                                    33


<210>  1079
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1079
ttcggcggag gaaccaaggt ggaaatcaaa cgt                                    33


<210>  1080
<211>  318
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1080
acggtagcgg ccccatctgt cttcatcttc ccgccatctg atgagcagtt gaaatctgga       60

actgcctctg ttgtgtgcct gctgaataac ttctatccca gagaggccaa agtacagtgg      120

aaggtggata acgccctcca atcgggtaac tcccaggaga gtgtcacaga gcaggacagc      180

aaggacagca cctacagcct cagcagcacc ctgacgctga gcaaagcaga ctacgagaaa      240

cacaaagtct acgcctgcga agtcacccat cagggcctga gctcgcccgt cacaaagagc      300

ttcaacaggg gagagtgt                                                    318


<210>  1081
<211>  453
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1081

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser Ser Tyr 
            20                  25                  30          


Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ile Ile Asn Thr Asn Asp Asp Thr Trp Tyr Ala Ser Trp Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ile Ser Asp Ala Tyr Val Phe Asp Tyr Ala Tyr Tyr Phe Thr Leu 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
        195                 200                 205             


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
    210                 215                 220                 


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
225                 230                 235                 240 


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
                245                 250                 255     


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
            260                 265                 270         


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
        275                 280                 285             


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser 
    290                 295                 300                 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
305                 310                 315                 320 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
                325                 330                 335     


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
            340                 345                 350         


Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln 
        355                 360                 365             


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
    370                 375                 380                 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
385                 390                 395                 400 


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
                405                 410                 415     


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
            420                 425                 430         


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
        435                 440                 445             


Leu Ser Pro Gly Lys 
    450             


<210>  1082
<211>  123
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1082

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser Ser Tyr 
            20                  25                  30          


Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ile Ile Asn Thr Asn Asp Asp Thr Trp Tyr Ala Ser Trp Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ile Ser Asp Ala Tyr Val Phe Asp Tyr Ala Tyr Tyr Phe Thr Leu 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  1083
<211>  30
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1083

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser 
            20                  25                  30  


<210>  1084
<211>  5
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  1084

Ser Tyr Asp Met Ser 
1               5   


<210>  1085
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1085

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
1               5                   10                  


<210>  1086
<211>  16
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  1086

Ile Ile Asn Thr Asn Asp Asp Thr Trp Tyr Ala Ser Trp Val Lys Gly 
1               5                   10                  15      


<210>  1087
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1087

Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1088
<211>  15
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  1088

Ile Ser Asp Ala Tyr Val Phe Asp Tyr Ala Tyr Tyr Phe Thr Leu 
1               5                   10                  15  


<210>  1089
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1089

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  1090
<211>  330
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1090

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  1091
<211>  1359
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1091
gaggtgcagc ttgtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt ctccctcagt agctacgaca tgagctgggt ccgtcaggct      120

ccagggaagg ggctggagtg gatcggaatc attaatacta atgatgacac atggtacgcg      180

agctgggtga aaggccgatt caccatctcc agagacaatt ccaagaacac cctgtatctt      240

caaatgaaca gcctgagagc tgaggacact gctgtgtatt actgtgctag aatatccgat      300

gcttatgttt ttgattatgc gtattacttt actttgtggg gccaagggac cctcgtcacc      360

gtctcgagcg cctccaccaa gggcccatcg gtcttccccc tggcaccctc ctccaagagc      420

acctctgggg gcacagcggc cctgggctgc ctggtcaagg actacttccc cgaaccggtg      480

acggtgtcgt ggaactcagg cgccctgacc agcggcgtgc acaccttccc ggctgtccta      540

cagtcctcag gactctactc cctcagcagc gtggtgaccg tgccctccag cagcttgggc      600

acccagacct acatctgcaa cgtgaatcac aagcccagca acaccaaggt ggacaagaaa      660

gttgagccca aatcttgtga caaaactcac acatgcccac cgtgcccagc acctgaactc      720

ctggggggac cgtcagtctt cctcttcccc ccaaaaccca aggacaccct catgatctcc      780

cggacccctg aggtcacatg cgtggtggtg gacgtgagcc acgaagaccc tgaggtcaag      840

ttcaactggt acgtggacgg cgtggaggtg cataatgcca agacaaagcc gcgggaggag      900

cagtacgcca gcacgtaccg tgtggtcagc gtcctcaccg tcctgcacca ggactggctg      960

aatggcaagg agtacaagtg caaggtctcc aacaaagccc tcccagcccc catcgagaaa     1020

accatctcca aagccaaagg gcagccccga gaaccacagg tgtacaccct gcccccatcc     1080

cgggaggaga tgaccaagaa ccaggtcagc ctgacctgcc tggtcaaagg cttctatccc     1140

agcgacatcg ccgtggagtg ggagagcaat gggcagccgg agaacaacta caagaccacg     1200

cctcccgtgc tggactccga cggctccttc ttcctctaca gcaagctcac cgtggacaag     1260

agcaggtggc agcaggggaa cgtcttctca tgctccgtga tgcatgaggc tctgcacaac     1320

cactacacgc agaagagcct ctccctgtct ccgggtaaa                            1359


<210>  1092
<211>  369
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1092
gaggtgcagc ttgtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt ctccctcagt agctacgaca tgagctgggt ccgtcaggct      120

ccagggaagg ggctggagtg gatcggaatc attaatacta atgatgacac atggtacgcg      180

agctgggtga aaggccgatt caccatctcc agagacaatt ccaagaacac cctgtatctt      240

caaatgaaca gcctgagagc tgaggacact gctgtgtatt actgtgctag aatatccgat      300

gcttatgttt ttgattatgc gtattacttt actttgtggg gccaagggac cctcgtcacc      360

gtctcgagc                                                              369


<210>  1093
<211>  90
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1093
gaggtgcagc ttgtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt ctccctcagt                                        90


<210>  1094
<211>  15
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  1094
agctacgaca tgagc                                                        15


<210>  1095
<211>  42
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1095
tgggtccgtc aggctccagg gaaggggctg gagtggatcg ga                          42


<210>  1096
<211>  48
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  1096
atcattaata ctaatgatga cacatggtac gcgagctggg tgaaaggc                    48


<210>  1097
<211>  96
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1097
cgattcacca tctccagaga caattccaag aacaccctgt atcttcaaat gaacagcctg       60

agagctgagg acactgctgt gtattactgt gctaga                                 96


<210>  1098
<211>  45
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  1098
atatccgatg cttatgtttt tgattatgcg tattacttta ctttg                       45


<210>  1099
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1099
tggggccaag ggaccctcgt caccgtctcg agc                                    33


<210>  1100
<211>  990
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1100
gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg       60

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      240

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttgagccc      300

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      360

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      420

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      480

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacgcc      540

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      600

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc      660

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggaggag      720

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc      780

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg      840

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg      900

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg      960

cagaagagcc tctccctgtc tccgggtaaa                                       990


<210>  1101
<211>  217
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1101

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Leu Ala Ser Gln Asn Ile Tyr Asn Ser 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Ala Gly Ala Asp Asn 
                85                  90                  95      


Ile Gly Asn Pro Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105                 110         


Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
        115                 120                 125             


Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
    130                 135                 140                 


Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
145                 150                 155                 160 


Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
                165                 170                 175     


Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
            180                 185                 190         


Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
        195                 200                 205             


Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215         


<210>  1102
<211>  111
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1102

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Leu Ala Ser Gln Asn Ile Tyr Asn Ser 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Ala Gly Ala Asp Asn 
                85                  90                  95      


Ile Gly Asn Pro Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110     


<210>  1103
<211>  23
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1103

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys 
            20              


<210>  1104
<211>  11
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  1104

Leu Ala Ser Gln Asn Ile Tyr Asn Ser Leu Ala 
1               5                   10      


<210>  1105
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1105

Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  1106
<211>  7
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  1106

Arg Ala Ser Thr Leu Ala Ser 
1               5           


<210>  1107
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1107

Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  1108
<211>  12
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  1108

Gln Gln Gly Ala Gly Ala Asp Asn Ile Gly Asn Pro 
1               5                   10          


<210>  1109
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1109

Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
1               5                   10      


<210>  1110
<211>  106
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1110

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105     


<210>  1111
<211>  651
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1111
gacatccaga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgtc tggccagtca gaacatttac aattctttag cctggtatca gcagaaacca      120

ggaaaagccc ctaagctcct gatctatagg gcatccactc tggcatctgg agtcccatca      180

aggttcagcg gcagtggatc tggaacagaa ttcactctca ccatcagcag cctgcagcct      240

gatgattttg caacttacta ctgtcaacag ggtgctggtg ctgataatat tggtaatcct      300

ttcggcggag gaaccaaggt ggaaatcaaa cgtacggtag cggccccatc tgtcttcatc      360

ttcccgccat ctgatgagca gttgaaatct ggaactgcct ctgttgtgtg cctgctgaat      420

aacttctatc ccagagaggc caaagtacag tggaaggtgg ataacgccct ccaatcgggt      480

aactcccagg agagtgtcac agagcaggac agcaaggaca gcacctacag cctcagcagc      540

accctgacgc tgagcaaagc agactacgag aaacacaaag tctacgcctg cgaagtcacc      600

catcagggcc tgagctcgcc cgtcacaaag agcttcaaca ggggagagtg t               651


<210>  1112
<211>  333
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1112
gacatccaga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgtc tggccagtca gaacatttac aattctttag cctggtatca gcagaaacca      120

ggaaaagccc ctaagctcct gatctatagg gcatccactc tggcatctgg agtcccatca      180

aggttcagcg gcagtggatc tggaacagaa ttcactctca ccatcagcag cctgcagcct      240

gatgattttg caacttacta ctgtcaacag ggtgctggtg ctgataatat tggtaatcct      300

ttcggcggag gaaccaaggt ggaaatcaaa cgt                                   333


<210>  1113
<211>  69
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1113
gacatccaga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgt                                                               69


<210>  1114
<211>  33
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  1114
ctggccagtc agaacattta caattcttta gcc                                    33


<210>  1115
<211>  45
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1115
tggtatcagc agaaaccagg aaaagcccct aagctcctga tctat                       45


<210>  1116
<211>  21
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  1116
agggcatcca ctctggcatc t                                                 21


<210>  1117
<211>  96
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1117
ggagtcccat caaggttcag cggcagtgga tctggaacag aattcactct caccatcagc       60

agcctgcagc ctgatgattt tgcaacttac tactgt                                 96


<210>  1118
<211>  36
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  1118
caacagggtg ctggtgctga taatattggt aatcct                                 36


<210>  1119
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1119
ttcggcggag gaaccaaggt ggaaatcaaa cgt                                    33


<210>  1120
<211>  318
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1120
acggtagcgg ccccatctgt cttcatcttc ccgccatctg atgagcagtt gaaatctgga       60

actgcctctg ttgtgtgcct gctgaataac ttctatccca gagaggccaa agtacagtgg      120

aaggtggata acgccctcca atcgggtaac tcccaggaga gtgtcacaga gcaggacagc      180

aaggacagca cctacagcct cagcagcacc ctgacgctga gcaaagcaga ctacgagaaa      240

cacaaagtct acgcctgcga agtcacccat cagggcctga gctcgcccgt cacaaagagc      300

ttcaacaggg gagagtgt                                                    318


<210>  1121
<211>  452
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1121

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Ser Ser 
            20                  25                  30          


Asp Tyr Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Cys Ile Asp Ala Gly Ser Ser Gly Asp Thr Tyr Phe Ala Ser 
    50                  55                  60                  


Ser Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Phe Cys Ala Arg His Leu Tyr Gly Ser Ile Thr Phe Ala Phe Gly Leu 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
        195                 200                 205             


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
    210                 215                 220                 


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
225                 230                 235                 240 


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
                245                 250                 255     


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
            260                 265                 270         


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
        275                 280                 285             


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser 
    290                 295                 300                 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
305                 310                 315                 320 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
                325                 330                 335     


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
            340                 345                 350         


Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln 
        355                 360                 365             


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
    370                 375                 380                 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
385                 390                 395                 400 


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
                405                 410                 415     


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
            420                 425                 430         


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
        435                 440                 445             


Leu Ser Pro Gly 
    450         


<210>  1122
<211>  123
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1122

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Ser Ser 
            20                  25                  30          


Asp Tyr Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Cys Ile Asp Ala Gly Ser Ser Gly Asp Thr Tyr Phe Ala Ser 
    50                  55                  60                  


Ser Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Phe Cys Ala Arg His Leu Tyr Gly Ser Ile Thr Phe Ala Phe Gly Leu 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  1123
<211>  30
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1123

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser 
            20                  25                  30  


<210>  1124
<211>  6
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  1124

Ser Ser Asp Tyr Met Cys 
1               5       


<210>  1125
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1125

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
1               5                   10                  


<210>  1126
<211>  18
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1126

Cys Ile Asp Ala Gly Ser Ser Gly Asp Thr Tyr Phe Ala Ser Ser Ala 
1               5                   10                  15      


Lys Gly 
        


<210>  1127
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1127

Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys Ala Arg 
            20                  25                  30          


<210>  1128
<211>  12
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  1128

His Leu Tyr Gly Ser Ile Thr Phe Ala Phe Gly Leu 
1               5                   10          


<210>  1129
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1129

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  1130
<211>  329
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1130

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly 
                325                 


<210>  1131
<211>  1356
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1131
gaggtgcagc ttgtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt ctccttcagt agcagcgact acatgtgctg ggtccgtcag      120

gctccaggga aggggctgga gtggatcgga tgcattgatg ctggtagtag tggtgacact      180

tacttcgcga gctctgcgaa aggccgattc accatctcca gagacaattc caagaacacc      240

gtgtatcttc aaatgaacag cctgagagct gaggacactg ctgtgtattt ctgtgctaga      300

catctttatg gtagtattac tttcgccttt ggcttgtggg gccaagggac cctcgtcacc      360

gtctcgagcg cctccaccaa gggcccatcg gtcttccccc tggcaccctc ctccaagagc      420

acctctgggg gcacagcggc cctgggctgc ctggtcaagg actacttccc cgaaccggtg      480

acggtgtcgt ggaactcagg cgccctgacc agcggcgtgc acaccttccc ggctgtccta      540

cagtcctcag gactctactc cctcagcagc gtggtgaccg tgccctccag cagcttgggc      600

acccagacct acatctgcaa cgtgaatcac aagcccagca acaccaaggt ggacaagaaa      660

gttgagccca aatcttgtga caaaactcac acatgcccac cgtgcccagc acctgaactc      720

ctggggggac cgtcagtctt cctcttcccc ccaaaaccca aggacaccct catgatctcc      780

cggacccctg aggtcacatg cgtggtggtg gacgtgagcc acgaagaccc tgaggtcaag      840

ttcaactggt acgtggacgg cgtggaggtg cataatgcca agacaaagcc gcgggaggag      900

cagtacgcca gcacgtaccg tgtggtcagc gtcctcaccg tcctgcacca ggactggctg      960

aatggcaagg agtacaagtg caaggtctcc aacaaagccc tcccagcccc catcgagaaa     1020

accatctcca aagccaaagg gcagccccga gaaccacagg tgtacaccct gcccccatcc     1080

cgggaggaga tgaccaagaa ccaggtcagc ctgacctgcc tggtcaaagg cttctatccc     1140

agcgacatcg ccgtggagtg ggagagcaat gggcagccgg agaacaacta caagaccacg     1200

cctcccgtgc tggactccga cggctccttc ttcctctaca gcaagctcac cgtggacaag     1260

agcaggtggc agcaggggaa cgtcttctca tgctccgtga tgcatgaggc tctgcacaac     1320

cactacacgc agaagagcct ctccctgtct ccgggt                               1356


<210>  1132
<211>  369
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1132
gaggtgcagc ttgtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt ctccttcagt agcagcgact acatgtgctg ggtccgtcag      120

gctccaggga aggggctgga gtggatcgga tgcattgatg ctggtagtag tggtgacact      180

tacttcgcga gctctgcgaa aggccgattc accatctcca gagacaattc caagaacacc      240

gtgtatcttc aaatgaacag cctgagagct gaggacactg ctgtgtattt ctgtgctaga      300

catctttatg gtagtattac tttcgccttt ggcttgtggg gccaagggac cctcgtcacc      360

gtctcgagc                                                              369


<210>  1133
<211>  90
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1133
gaggtgcagc ttgtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt ctccttcagt                                        90


<210>  1134
<211>  18
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  1134
agcagcgact acatgtgc                                                     18


<210>  1135
<211>  42
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1135
tgggtccgtc aggctccagg gaaggggctg gagtggatcg ga                          42


<210>  1136
<211>  54
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1136
tgcattgatg ctggtagtag tggtgacact tacttcgcga gctctgcgaa aggc             54


<210>  1137
<211>  96
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1137
cgattcacca tctccagaga caattccaag aacaccgtgt atcttcaaat gaacagcctg       60

agagctgagg acactgctgt gtatttctgt gctaga                                 96


<210>  1138
<211>  36
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  1138
catctttatg gtagtattac tttcgccttt ggcttg                                 36


<210>  1139
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1139
tggggccaag ggaccctcgt caccgtctcg agc                                    33


<210>  1140
<211>  987
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1140
gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg       60

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      240

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttgagccc      300

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      360

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      420

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      480

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacgcc      540

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      600

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc      660

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggaggag      720

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc      780

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg      840

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg      900

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg      960

cagaagagcc tctccctgtc tccgggt                                          987


<210>  1141
<211>  217
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1141

Ala Ala Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Gly Ser Asp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gly Thr Tyr Tyr Ser Ser Gly 
                85                  90                  95      


Trp Tyr Thr Ala Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105                 110         


Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
        115                 120                 125             


Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
    130                 135                 140                 


Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
145                 150                 155                 160 


Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
                165                 170                 175     


Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
            180                 185                 190         


Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
        195                 200                 205             


Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215         


<210>  1142
<211>  111
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1142

Ala Ala Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Gly Ser Asp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gly Thr Tyr Tyr Ser Ser Gly 
                85                  90                  95      


Trp Tyr Thr Ala Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110     


<210>  1143
<211>  23
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1143

Ala Ala Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys 
            20              


<210>  1144
<211>  11
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  1144

Gln Ala Ser Gln Ser Ile Gly Ser Asp Leu Ala 
1               5                   10      


<210>  1145
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1145

Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  1146
<211>  7
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  1146

Asp Ala Ser Thr Leu Ala Ser 
1               5           


<210>  1147
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1147

Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  1148
<211>  12
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  1148

Gln Gly Thr Tyr Tyr Ser Ser Gly Trp Tyr Thr Ala 
1               5                   10          


<210>  1149
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1149

Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
1               5                   10      


<210>  1150
<211>  106
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1150

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105     


<210>  1151
<211>  651
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1151
gcagcccaga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgtc aggccagtca gagcattggt agcgacttag cctggtatca gcagaaacca      120

ggaaaagccc ctaagctcct gatctatgat gcatccactc tggcatctgg agtcccatca      180

aggttcagcg gcagtggatc tggaacagaa ttcactctca ccatcagcag cctgcagcct      240

gatgattttg caacttacta ctgtcaaggc acttattata gtagtggttg gtacactgct      300

ttcggcggag gaaccaaggt ggaaatcaaa cgtacggtag cggccccatc tgtcttcatc      360

ttcccgccat ctgatgagca gttgaaatct ggaactgcct ctgttgtgtg cctgctgaat      420

aacttctatc ccagagaggc caaagtacag tggaaggtgg ataacgccct ccaatcgggt      480

aactcccagg agagtgtcac agagcaggac agcaaggaca gcacctacag cctcagcagc      540

accctgacgc tgagcaaagc agactacgag aaacacaaag tctacgcctg cgaagtcacc      600

catcagggcc tgagctcgcc cgtcacaaag agcttcaaca ggggagagtg t               651


<210>  1152
<211>  333
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1152
gcagcccaga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgtc aggccagtca gagcattggt agcgacttag cctggtatca gcagaaacca      120

ggaaaagccc ctaagctcct gatctatgat gcatccactc tggcatctgg agtcccatca      180

aggttcagcg gcagtggatc tggaacagaa ttcactctca ccatcagcag cctgcagcct      240

gatgattttg caacttacta ctgtcaaggc acttattata gtagtggttg gtacactgct      300

ttcggcggag gaaccaaggt ggaaatcaaa cgt                                   333


<210>  1153
<211>  69
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1153
gcagcccaga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgt                                                               69


<210>  1154
<211>  33
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  1154
caggccagtc agagcattgg tagcgactta gcc                                    33


<210>  1155
<211>  45
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1155
tggtatcagc agaaaccagg aaaagcccct aagctcctga tctat                       45


<210>  1156
<211>  21
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  1156
gatgcatcca ctctggcatc t                                                 21


<210>  1157
<211>  96
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1157
ggagtcccat caaggttcag cggcagtgga tctggaacag aattcactct caccatcagc       60

agcctgcagc ctgatgattt tgcaacttac tactgt                                 96


<210>  1158
<211>  36
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  1158
caaggcactt attatagtag tggttggtac actgct                                 36


<210>  1159
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1159
ttcggcggag gaaccaaggt ggaaatcaaa cgt                                    33


<210>  1160
<211>  318
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1160
acggtagcgg ccccatctgt cttcatcttc ccgccatctg atgagcagtt gaaatctgga       60

actgcctctg ttgtgtgcct gctgaataac ttctatccca gagaggccaa agtacagtgg      120

aaggtggata acgccctcca atcgggtaac tcccaggaga gtgtcacaga gcaggacagc      180

aaggacagca cctacagcct cagcagcacc ctgacgctga gcaaagcaga ctacgagaaa      240

cacaaagtct acgcctgcga agtcacccat cagggcctga gctcgcccgt cacaaagagc      300

ttcaacaggg gagagtgt                                                    318


<210>  1161
<211>  444
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1161

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Arg Asp 
            20                  25                  30          


Tyr Trp Ile Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Cys Ile Ser Ala Gly Gly Gly Ser Thr Asp Tyr Ala Asn Trp 
    50                  55                  60                  


Val Asn Gly Arg Phe Thr Ile Ser Arg Asp Ile Ser Lys Asn Thr Gly 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Gly Asn Leu Glu Ile Trp Gly Gln Gly Thr Leu Val Thr Val 
            100                 105                 110         


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
        115                 120                 125             


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
    130                 135                 140                 


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
145                 150                 155                 160 


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
                165                 170                 175     


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
            180                 185                 190         


Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
        195                 200                 205             


Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
    210                 215                 220                 


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
225                 230                 235                 240 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                245                 250                 255     


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
            260                 265                 270         


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        275                 280                 285             


Arg Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
    290                 295                 300                 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
305                 310                 315                 320 


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
                325                 330                 335     


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
            340                 345                 350         


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
        355                 360                 365             


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
    370                 375                 380                 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
385                 390                 395                 400 


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
                405                 410                 415     


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            420                 425                 430         


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 


<210>  1162
<211>  114
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1162

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Arg Asp 
            20                  25                  30          


Tyr Trp Ile Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Cys Ile Ser Ala Gly Gly Gly Ser Thr Asp Tyr Ala Asn Trp 
    50                  55                  60                  


Val Asn Gly Arg Phe Thr Ile Ser Arg Asp Ile Ser Lys Asn Thr Gly 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Gly Asn Leu Glu Ile Trp Gly Gln Gly Thr Leu Val Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  1163
<211>  30
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1163

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser 
            20                  25                  30  


<210>  1164
<211>  6
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  1164

Arg Asp Tyr Trp Ile Cys 
1               5       


<210>  1165
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1165

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
1               5                   10                  


<210>  1166
<211>  17
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  1166

Cys Ile Ser Ala Gly Gly Gly Ser Thr Asp Tyr Ala Asn Trp Val Asn 
1               5                   10                  15      


Gly 
    


<210>  1167
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1167

Arg Phe Thr Ile Ser Arg Asp Ile Ser Lys Asn Thr Gly Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Gly 
            20                  25                  30          


<210>  1168
<211>  4
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  1168

Asn Leu Glu Ile 
1               


<210>  1169
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1169

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  1170
<211>  330
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1170

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  1171
<211>  1332
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1171
gaggtgcagc ttgtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccgtcagt agggactact ggatatgttg ggtccgtcag      120

gctccaggga aggggctgga gtggattgga tgcattagtg ctggtggtgg tagcacagac      180

tacgcgaact gggtgaatgg ccgattcacc atctccagag acatctccaa gaacaccggt      240

tatcttcaaa tgaacagcct gagagctgag gacactgctg tgtattactg tgcgggaaat      300

ctagagatct ggggccaagg gaccctcgtc accgtctcga gcgcctccac caagggccca      360

tcggtcttcc ccctggcacc ctcctccaag agcacctctg ggggcacagc ggccctgggc      420

tgcctggtca aggactactt ccccgaaccg gtgacggtgt cgtggaactc aggcgccctg      480

accagcggcg tgcacacctt cccggctgtc ctacagtcct caggactcta ctccctcagc      540

agcgtggtga ccgtgccctc cagcagcttg ggcacccaga cctacatctg caacgtgaat      600

cacaagccca gcaacaccaa ggtggacaag aaagttgagc ccaaatcttg tgacaaaact      660

cacacatgcc caccgtgccc agcacctgaa ctcctggggg gaccgtcagt cttcctcttc      720

cccccaaaac ccaaggacac cctcatgatc tcccggaccc ctgaggtcac atgcgtggtg      780

gtggacgtga gccacgaaga ccctgaggtc aagttcaact ggtacgtgga cggcgtggag      840

gtgcataatg ccaagacaaa gccgcgggag gagcagtacg ccagcacgta ccgtgtggtc      900

agcgtcctca ccgtcctgca ccaggactgg ctgaatggca aggagtacaa gtgcaaggtc      960

tccaacaaag ccctcccagc ccccatcgag aaaaccatct ccaaagccaa agggcagccc     1020

cgagaaccac aggtgtacac cctgccccca tcccgggagg agatgaccaa gaaccaggtc     1080

agcctgacct gcctggtcaa aggcttctat cccagcgaca tcgccgtgga gtgggagagc     1140

aatgggcagc cggagaacaa ctacaagacc acgcctcccg tgctggactc cgacggctcc     1200

ttcttcctct acagcaagct caccgtggac aagagcaggt ggcagcaggg gaacgtcttc     1260

tcatgctccg tgatgcatga ggctctgcac aaccactaca cgcagaagag cctctccctg     1320

tctccgggta aa                                                         1332


<210>  1172
<211>  342
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1172
gaggtgcagc ttgtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccgtcagt agggactact ggatatgttg ggtccgtcag      120

gctccaggga aggggctgga gtggattgga tgcattagtg ctggtggtgg tagcacagac      180

tacgcgaact gggtgaatgg ccgattcacc atctccagag acatctccaa gaacaccggt      240

tatcttcaaa tgaacagcct gagagctgag gacactgctg tgtattactg tgcgggaaat      300

ctagagatct ggggccaagg gaccctcgtc accgtctcga gc                         342


<210>  1173
<211>  90
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1173
gaggtgcagc ttgtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccgtcagt                                        90


<210>  1174
<211>  18
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  1174
agggactact ggatatgt                                                     18


<210>  1175
<211>  42
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1175
tgggtccgtc aggctccagg gaaggggctg gagtggattg ga                          42


<210>  1176
<211>  51
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  1176
tgcattagtg ctggtggtgg tagcacagac tacgcgaact gggtgaatgg c                51


<210>  1177
<211>  96
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1177
cgattcacca tctccagaga catctccaag aacaccggtt atcttcaaat gaacagcctg       60

agagctgagg acactgctgt gtattactgt gcggga                                 96


<210>  1178
<211>  12
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  1178
aatctagaga tc                                                           12


<210>  1179
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1179
tggggccaag ggaccctcgt caccgtctcg agc                                    33


<210>  1180
<211>  990
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1180
gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg       60

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      240

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttgagccc      300

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      360

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      420

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      480

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacgcc      540

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      600

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc      660

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggaggag      720

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc      780

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg      840

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg      900

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg      960

cagaagagcc tctccctgtc tccgggtaaa                                       990


<210>  1181
<211>  220
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1181

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ser Ser Pro Ser Ile Tyr Ser Gly 
            20                  25                  30          


Ala Phe Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Phe 
        35                  40                  45              


Leu Ile Tyr Glu Ala Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu 
65                  70                  75                  80  


Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Leu Gly Phe Tyr Asp Cys 
                85                  90                  95      


Ser Ser Val Asp Cys His Ala Phe Gly Gly Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
        115                 120                 125             


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
    130                 135                 140                 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
145                 150                 155                 160 


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
                165                 170                 175     


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
            180                 185                 190         


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
        195                 200                 205             


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 220 


<210>  1182
<211>  114
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1182

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ser Ser Pro Ser Ile Tyr Ser Gly 
            20                  25                  30          


Ala Phe Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Phe 
        35                  40                  45              


Leu Ile Tyr Glu Ala Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu 
65                  70                  75                  80  


Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Leu Gly Phe Tyr Asp Cys 
                85                  90                  95      


Ser Ser Val Asp Cys His Ala Phe Gly Gly Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys Arg 
        


<210>  1183
<211>  23
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1183

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys 
            20              


<210>  1184
<211>  13
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  1184

Gln Ser Ser Pro Ser Ile Tyr Ser Gly Ala Phe Leu Ser 
1               5                   10              


<210>  1185
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1185

Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Phe Leu Ile Tyr 
1               5                   10                  15  


<210>  1186
<211>  7
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  1186

Glu Ala Ser Lys Leu Ala Ser 
1               5           


<210>  1187
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1187

Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  1188
<211>  13
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  1188

Leu Gly Phe Tyr Asp Cys Ser Ser Val Asp Cys His Ala 
1               5                   10              


<210>  1189
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1189

Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
1               5                   10      


<210>  1190
<211>  106
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1190

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105     


<210>  1191
<211>  660
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1191
gacatccaga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgtc agtccagtcc gagtatctat agtggcgcct tcttatcctg gtatcagcag      120

aaaccaggaa aagcccctaa gttcctgatc tatgaagcct ccaaactggc atctggagtc      180

ccatcaaggt tcagcggcag tggatctgga acagaattca ctctcaccat cagcagcctg      240

cagcctgatg attttgcaac ttactactgt ctaggcttct atgattgtag cagtgttgat      300

tgccatgctt tcggcggagg aaccaaggtg gaaatcaaac gtacggtagc ggccccatct      360

gtcttcatct tcccgccatc tgatgagcag ttgaaatctg gaactgcctc tgttgtgtgc      420

ctgctgaata acttctatcc cagagaggcc aaagtacagt ggaaggtgga taacgccctc      480

caatcgggta actcccagga gagtgtcaca gagcaggaca gcaaggacag cacctacagc      540

ctcagcagca ccctgacgct gagcaaagca gactacgaga aacacaaagt ctacgcctgc      600

gaagtcaccc atcagggcct gagctcgccc gtcacaaaga gcttcaacag gggagagtgt      660


<210>  1192
<211>  342
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1192
gacatccaga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgtc agtccagtcc gagtatctat agtggcgcct tcttatcctg gtatcagcag      120

aaaccaggaa aagcccctaa gttcctgatc tatgaagcct ccaaactggc atctggagtc      180

ccatcaaggt tcagcggcag tggatctgga acagaattca ctctcaccat cagcagcctg      240

cagcctgatg attttgcaac ttactactgt ctaggcttct atgattgtag cagtgttgat      300

tgccatgctt tcggcggagg aaccaaggtg gaaatcaaac gt                         342


<210>  1193
<211>  69
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1193
gacatccaga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgt                                                               69


<210>  1194
<211>  39
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1194
cagtccagtc cgagtatcta tagtggcgcc ttcttatcc                              39


<210>  1195
<211>  45
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1195
tggtatcagc agaaaccagg aaaagcccct aagttcctga tctat                       45


<210>  1196
<211>  21
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  1196
gaagcctcca aactggcatc t                                                 21


<210>  1197
<211>  96
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1197
ggagtcccat caaggttcag cggcagtgga tctggaacag aattcactct caccatcagc       60

agcctgcagc ctgatgattt tgcaacttac tactgt                                 96


<210>  1198
<211>  39
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1198
ctaggcttct atgattgtag cagtgttgat tgccatgct                              39


<210>  1199
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1199
ttcggcggag gaaccaaggt ggaaatcaaa cgt                                    33


<210>  1200
<211>  318
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1200
acggtagcgg ccccatctgt cttcatcttc ccgccatctg atgagcagtt gaaatctgga       60

actgcctctg ttgtgtgcct gctgaataac ttctatccca gagaggccaa agtacagtgg      120

aaggtggata acgccctcca atcgggtaac tcccaggaga gtgtcacaga gcaggacagc      180

aaggacagca cctacagcct cagcagcacc ctgacgctga gcaaagcaga ctacgagaaa      240

cacaaagtct acgcctgcga agtcacccat cagggcctga gctcgcccgt cacaaagagc      300

ttcaacaggg gagagtgt                                                    318


<210>  1201

<400>  1201
000

<210>  1202

<400>  1202
000

<210>  1203

<400>  1203
000

<210>  1204

<400>  1204
000

<210>  1205

<400>  1205
000

<210>  1206

<400>  1206
000

<210>  1207

<400>  1207
000

<210>  1208

<400>  1208
000

<210>  1209

<400>  1209
000

<210>  1210

<400>  1210
000

<210>  1211

<400>  1211
000

<210>  1212

<400>  1212
000

<210>  1213

<400>  1213
000

<210>  1214

<400>  1214
000

<210>  1215

<400>  1215
000

<210>  1216

<400>  1216
000

<210>  1217

<400>  1217
000

<210>  1218

<400>  1218
000

<210>  1219

<400>  1219
000

<210>  1220

<400>  1220
000

<210>  1221

<400>  1221
000

<210>  1222

<400>  1222
000

<210>  1223

<400>  1223
000

<210>  1224

<400>  1224
000

<210>  1225

<400>  1225
000

<210>  1226

<400>  1226
000

<210>  1227

<400>  1227
000

<210>  1228

<400>  1228
000

<210>  1229

<400>  1229
000

<210>  1230

<400>  1230
000

<210>  1231

<400>  1231
000

<210>  1232

<400>  1232
000

<210>  1233

<400>  1233
000

<210>  1234

<400>  1234
000

<210>  1235

<400>  1235
000

<210>  1236

<400>  1236
000

<210>  1237

<400>  1237
000

<210>  1238

<400>  1238
000

<210>  1239

<400>  1239
000

<210>  1240

<400>  1240
000

<210>  1241
<211>  38
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES
<222>  (38)..(38)
<223>  AMIDATION

<400>  1241

His Ser Asp Gly Ile Phe Thr Asp Ser Tyr Ser Arg Tyr Arg Lys Gln 
1               5                   10                  15      


Met Ala Val Lys Lys Tyr Leu Ala Ala Val Leu Gly Lys Arg Tyr Lys 
            20                  25                  30          


Gln Arg Val Lys Asn Lys 
        35              


<210>  1242
<211>  27
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  AMIDATION

<400>  1242

His Ser Asp Gly Ile Phe Thr Asp Ser Tyr Ser Arg Tyr Arg Lys Gln 
1               5                   10                  15      


Met Ala Val Lys Lys Tyr Leu Ala Ala Val Leu 
            20                  25          


<210>  1243
<211>  28
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  AMIDATION

<400>  1243

His Ser Asp Ala Val Phe Thr Asp Asn Tyr Thr Arg Leu Arg Lys Gln 
1               5                   10                  15      


Met Ala Val Lys Lys Tyr Leu Asn Ser Ile Leu Asn 
            20                  25              


<210>  1244
<211>  330
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1244

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  1245
<211>  330
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1245

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Ala 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  1246
<211>  330
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1246

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 



