                         SEQUENCE LISTING

<110>  RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL
       RODINO-KLAPAC, et al.
 
<120>  ADENO-ASSOCIATED VIRUS VECTOR DELIVERY OF MICRORNA-29 AND 
       MICRO-DYSTROPHIN TO TREAT MUSCULAR DYSTROPHY

<130>  28335/50575B

<150>  US 62/323,163
<151>  2016-04-15

<150>  US 62/473,253
<151>  2017-03-17

<160>  13    

<170>  PatentIn version 3.5

<210>  1
<211>  5910
<212>  DNA
<213>  Adeno-associated virus


<220>
<221>  promoter
<222>  (120)..(526)
<223>  CMV promotor

<220>
<221>  Intron
<222>  (927)..(1087)
<223>  EF1a intron

<220>
<221>  misc_feature
<222>  (1088)..(1375)
<223>  shRNA-miR29-c

<220>
<221>  misc_feature
<222>  (1257)..(1284)
<223>  miR-29c

<220>
<221>  Intron
<222>  (1380)..(1854)
<223>  EF1a intron

<220>
<221>  misc_feature
<222>  (1896)..(2091)
<223>  polyA

<400>  1
cagcagctgc gcgctcgctc gctcactgag gccgcccggg caaagcccgg gcgtcgggcg       60

acctttggtc gcccggcctc agtgagcgag cgagcgcgca gagagggagt ggggttaaac      120

tcgttacata acttacggta aatggcccgc ctggctgacc gcccaacgac ccccgcccat      180

tgacgtcaat aatgacgtat gttcccatag taacgccaat agggactttc cattgacgtc      240

aatgggtgga gtatttacgg taaactgccc acttggcagt acatcaagtg tatcatatgc      300

caagtacgcc ccctattgac gtcaatgacg gtaaatggcc cgcctggcat tatgcccagt      360

acatgacctt atgggacttt cctacttggc agtacatcta cgtattagtc atcgctatta      420

ccatggtgat gcggttttgg cagtacatca atgggcgtgg atagcggttt gactcacggg      480

gatttccaag tctccacccc attgacgtca atgggagttt gttttggcac caaaatcaac      540

gggactttcc aaaatgtcgt aacaactccg ccccattgac gcaaatgggc ggtaggcgtg      600

tacggtggga ggtctatata agcagagctc gtttagtgaa ccgtcagatc gcctggagac      660

gccatccacg ctgttttgac ctccatagaa gacaccggga ccgatccagc ctccggactc      720

tagaggatcc ggtactcgag gaactgaaaa accagaaagt taactggtaa gtttagtctt      780

tttgtctttt atttcaggtc ccggatccgg tggtggtgca aatcaaagaa ctgctcctca      840

gtggatgttg cctttacttc taggcctgta cggaagtgtt acttctgctc taaaagctgc      900

ggaattgtac ccggggccga tccaccggtc tttttcgcaa cgggtttgcc gccagaacac      960

aggtaagtgc cgtgtgtggt tcccgcgggc ggcgacgggg cccgtgcgtc ccagcgcaca     1020

tgttcggcga ggcggggcct gcgagcgcgg ccaccgagaa tcggacgggg gtagtctcaa     1080

gctggccggc ctgtttgaat gaggcttcag tactttacag aatcgttgcc tgcacatctt     1140

ggaaacactt gctgggatta cttcttcagg ttaacccaac agaaggctcg agaaggtata     1200

ttgctgttga cagtgagcgc aaccgatttc aaatggtgct agagtgaagc cacagatgtc     1260

tagcaccatt tgaaatcggt tatgcctact gcctcggaat tcaaggggct actttaggag     1320

caattatctt gtttactaaa actgaatacc ttgctatctc tttgatacat tggccggcct     1380

gctctggtgc ctggcctcgc gccgccgtgt atcgccccgc cctgggcggc aaggctggcc     1440

cggtcggcac cagttgcgtg agcggaaaga tggccgcttc ccggccctgc tgcagggagc     1500

tcaaaatgga ggacgcggcg ctcgggagag cgggcgggtg agtcacccac acaaaggaaa     1560

agggcctttc cgtcctcagc cgtcgcttca tgtgactcca cggagtaccg ggcgccgtcc     1620

aggcacctcg attagttctc gagcttttgg agtacgtcgt ctttaggttg gggggagggg     1680

ttttatgcga tggagtttcc ccacactgag tgggtggaga ctgaagttag gccagcttgg     1740

cacttgatgt aattctcctt ggaatttgcc ctttttgagt ttggatcttg gttcattctc     1800

aagcctcaga cagtggttca aagttttttt cttccatttc aggtgtcgtg aaaagctagc     1860

gctaccggac tcagatctcg agctcaagct gcggggatcc agacatgata agatacattg     1920

atgagtttgg acaaaccaca actagaatgc agtgaaaaaa atgctttatt tgtgaaattt     1980

gtgatgctat tgctttattt gtaaccatta taagctgcaa taaacaagtt aacaacaaca     2040

attgcattca ttttatgttt caggttcagg gggaggtgtg ggaggttttt tcactagtag     2100

catggctacg tagataagta gcatggcggg ttaatcatta actacaagga acccctagtg     2160

atggagttgg ccactccctc tctgcgcgct cgctcgctca ctgaggccgg gcgaccaaag     2220

gtcgcccgac gcccgggctt tgcccgggcg gcctcagtga gcgagcgagc gcgccagctg     2280

gcgtaatagc gaagaggccc gcaccgatcg cccttcccaa cagttgcgca gcctgaatgg     2340

cgaatggaat tccagacgat tgagcgtcaa aatgtaggta tttccatgag cgtttttcct     2400

gttgcaatgg ctggcggtaa tattgttctg gatattacca gcaaggccga tagtttgagt     2460

tcttctactc aggcaagtga tgttattact aatcaaagaa gtattgcgac aacggttaat     2520

ttgcgtgatg gacagactct tttactcggt ggcctcactg attataaaaa cacttctcag     2580

gattctggcg taccgttcct gtctaaaatc cctttaatcg gcctcctgtt tagctcccgc     2640

tctgattcta acgaggaaag cacgttatac gtgctcgtca aagcaaccat agtacgcgcc     2700

ctgtagcggc gcattaagcg cggcgggtgt ggtggttacg cgcagcgtga ccgctacact     2760

tgccagcgcc ctagcgcccg ctcctttcgc tttcttccct tcctttctcg ccacgttcgc     2820

cggctttccc cgtcaagctc taaatcgggg gctcccttta gggttccgat ttagtgcttt     2880

acggcacctc gaccccaaaa aacttgatta gggtgatggt tcacgtagtg ggccatcgcc     2940

ctgatagacg gtttttcgcc ctttgacgtt ggagtccacg ttctttaata gtggactctt     3000

gttccaaact ggaacaacac tcaaccctat ctcggtctat tcttttgatt tataagggat     3060

tttgccgatt tcggcctatt ggttaaaaaa tgagctgatt taacaaaaat ttaacgcgaa     3120

ttttaacaaa atattaacgt ttacaattta aatatttgct tatacaatct tcctgttttt     3180

ggggcttttc tgattatcaa ccggggtaca tatgattgac atgctagttt tacgattacc     3240

gttcatcgat tctcttgttt gctccagact ctcaggcaat gacctgatag cctttgtaga     3300

gacctctcaa aaatagctac cctctccggc atgaatttat cagctagaac ggttgaatat     3360

catattgatg gtgatttgac tgtctccggc ctttctcacc cgtttgaatc tttacctaca     3420

cattactcag gcattgcatt taaaatatat gagggttcta aaaattttta tccttgcgtt     3480

gaaataaagg cttctcccgc aaaagtatta cagggtcata atgtttttgg tacaaccgat     3540

ttagctttat gctctgaggc tttattgctt aattttgcta attctttgcc ttgcctgtat     3600

gatttattgg atgttggaat tcctgatgcg gtattttctc cttacgcatc tgtgcggtat     3660

ttcacaccgc atatggtgca ctctcagtac aatctgctct gatgccgcat agttaagcca     3720

gccccgacac ccgccaacac ccgctgacgc gccctgacgg gcttgtctgc tcccggcatc     3780

cgcttacaga caagctgtga ccgtctccgg gagctgcatg tgtcagaggt tttcaccgtc     3840

atcaccgaaa cgcgcgagac gaaagggcct cgtgatacgc ctatttttat aggttaatgt     3900

catgataata atggtttctt agacgtcagg tggcactttt cggggaaatg tgcgcggaac     3960

ccctatttgt ttatttttct aaatacattc aaatatgtat ccgctcatga gacaataacc     4020

ctgataaatg cttcaataat attgaaaaag gaagagtatg agtattcaac atttccgtgt     4080

cgcccttatt cccttttttg cggcattttg ccttcctgtt tttgctcacc cagaaacgct     4140

ggtgaaagta aaagatgctg aagatcagtt gggtgcacga gtgggttaca tcgaactgga     4200

tctcaacagc ggtaagatcc ttgagagttt tcgccccgaa gaacgttttc caatgatgag     4260

cacttttaaa gttctgctat gtggcgcggt attatcccgt attgacgccg ggcaagagca     4320

actcggtcgc cgcatacact attctcagaa tgacttggtt gagtactcac cagtcacaga     4380

aaagcatctt acggatggca tgacagtaag agaattatgc agtgctgcca taaccatgag     4440

tgataacact gcggccaact tacttctgac aacgatcgga ggaccgaagg agctaaccgc     4500

ttttttgcac aacatggggg atcatgtaac tcgccttgat cgttgggaac cggagctgaa     4560

tgaagccata ccaaacgacg agcgtgacac cacgatgcct gtagcaatgg caacaacgtt     4620

gcgcaaacta ttaactggcg aactacttac tctagcttcc cggcaacaat taatagactg     4680

gatggaggcg gataaagttg caggaccact tctgcgctcg gcccttccgg ctggctggtt     4740

tattgctgat aaatctggag ccggtgagcg tgggtctcgc ggtatcattg cagcactggg     4800

gccagatggt aagccctccc gtatcgtagt tatctacacg acggggagtc aggcaactat     4860

ggatgaacga aatagacaga tcgctgagat aggtgcctca ctgattaagc attggtaact     4920

gtcagaccaa gtttactcat atatacttta gattgattta aaacttcatt tttaatttaa     4980

aaggatctag gtgaagatcc tttttgataa tctcatgacc aaaatccctt aacgtgagtt     5040

ttcgttccac tgagcgtcag accccgtaga aaagatcaaa ggatcttctt gagatccttt     5100

ttttctgcgc gtaatctgct gcttgcaaac aaaaaaacca ccgctaccag cggtggtttg     5160

tttgccggat caagagctac caactctttt tccgaaggta actggcttca gcagagcgca     5220

gataccaaat actgtccttc tagtgtagcc gtagttaggc caccacttca agaactctgt     5280

agcaccgcct acatacctcg ctctgctaat cctgttacca gtggctgctg ccagtggcga     5340

taagtcgtgt cttaccgggt tggactcaag acgatagtta ccggataagg cgcagcggtc     5400

gggctgaacg gggggttcgt gcacacagcc cagcttggag cgaacgacct acaccgaact     5460

gagataccta cagcgtgagc tatgagaaag cgccacgctt cccgaaggga gaaaggcgga     5520

caggtatccg gtaagcggca gggtcggaac aggagagcgc acgagggagc ttccaggggg     5580

aaacgcctgg tatctttata gtcctgtcgg gtttcgccac ctctgacttg agcgtcgatt     5640

tttgtgatgc tcgtcagggg ggcggagcct atggaaaaac gccagcaacg cggccttttt     5700

acggttcctg gccttttgct ggccttttgc tcacatgttc tttcctgcgt tatcccctga     5760

ttctgtggat aaccgtatta ccgcctttga gtgagctgat accgctcgcc gcagccgaac     5820

gaccgagcgc agcgagtcag tgagcgagga agcggaagag cgcccaatac gcaaaccgcc     5880

tctccccgcg cgttggccga ttcattaatg                                      5910


<210>  2
<211>  296
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(8)
<223>  FSE-I cut site

<220>
<221>  misc_feature
<222>  (9)..(136)
<223>  miR-30 backbone

<220>
<221>  misc_feature
<222>  (139)..(160)
<223>  miR-29c target (sense) strand

<220>
<221>  misc_feature
<222>  (161)..(175)
<223>  miR-29c target (sense) strand

<220>
<221>  misc_feature
<222>  (176)..(199)
<223>  miR-30 stem loop

<220>
<221>  misc_feature
<222>  (200)..(288)
<223>  miR-29c guide (antisense) strand

<220>
<221>  misc_feature
<222>  (289)..(296)
<223>  miR-30 backbone

<400>  2
ggccggcctg tttgaatgag gcttcagtac tttacagaat cgttgcctgc acatcttgga       60

aacacttgct gggattactt cttcaggtta acccaacaga aggctcgaga aggtatattg      120

ctgttgacag tgagcgcaac cgatttcaaa tggtgctaga gtgaagccac agatgtctag      180

caccatttga aatcggttat gcctactgcc tcggaattca aggggctact ttaggagcaa      240

ttatcttgtt tactaaaact gaataccttg ctatctcttt gatacattgg ccggcc          296


<210>  3
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  3
accgatttca aatggtgcta ga                                                22


<210>  4
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  4
tctagcacca tttgaaatcg gtta                                              24


<210>  5
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  5
gtgaagccac agatg                                                        15


<210>  6
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  miR-30 backbone

<220>
<221>  misc_feature
<222>  (20)..(42)
<223>  miR-29c target (sense) strand

<220>
<221>  misc_feature
<222>  (43)..(57)
<223>  miR-30 stem loop

<220>
<221>  misc_feature
<222>  (58)..(81)
<223>  miR-29c guide (antisense) strand

<220>
<221>  misc_feature
<222>  (82)..(98)
<223>  miR-30 backbone

<400>  6
ugcuguugac agugagcgca accgauuuca aauggugcua gagugaagcc acagaugucu       60

agcaccauuu gaaaucgguu augccuacug ccucggaa                               98


<210>  7
<211>  3581
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(3579)

<400>  7
atg ctg tgg tgg gag gag gtg gag gat tgt tat gaa agg gag gac gtg         48
Met Leu Trp Trp Glu Glu Val Glu Asp Cys Tyr Glu Arg Glu Asp Val           
1               5                   10                  15                

cag aag aag act ttt acc aag tgg gtg aac gct cag ttc agc aaa ttt         96
Gln Lys Lys Thr Phe Thr Lys Trp Val Asn Ala Gln Phe Ser Lys Phe           
            20                  25                  30                    

ggg aag cag cac atc gag aat ctg ttt tcc gac ctg cag gat ggg aga        144
Gly Lys Gln His Ile Glu Asn Leu Phe Ser Asp Leu Gln Asp Gly Arg           
        35                  40                  45                        

cgg ctg ctg gat ctg ctg gaa gga ctg act ggc cag aag ctg ccc aaa        192
Arg Leu Leu Asp Leu Leu Glu Gly Leu Thr Gly Gln Lys Leu Pro Lys           
    50                  55                  60                            

gag aag ggg agc act agg gtg cac gcc ctg aac aac gtg aac aaa gct        240
Glu Lys Gly Ser Thr Arg Val His Ala Leu Asn Asn Val Asn Lys Ala           
65                  70                  75                  80            

ctg aga gtg ctg cag aac aac aac gtg gat ctg gtg aat att ggc agt        288
Leu Arg Val Leu Gln Asn Asn Asn Val Asp Leu Val Asn Ile Gly Ser           
                85                  90                  95                

act gat atc gtg gac ggg aac cac aaa ctg aca ctg ggc ctg atc tgg        336
Thr Asp Ile Val Asp Gly Asn His Lys Leu Thr Leu Gly Leu Ile Trp           
            100                 105                 110                   

aac att att ctg cac tgg cag gtg aaa aat gtg atg aag aac atc atg        384
Asn Ile Ile Leu His Trp Gln Val Lys Asn Val Met Lys Asn Ile Met           
        115                 120                 125                       

gcc ggg ctg cag cag acc aat tcc gag aag atc ctg ctg tct tgg gtg        432
Ala Gly Leu Gln Gln Thr Asn Ser Glu Lys Ile Leu Leu Ser Trp Val           
    130                 135                 140                           

cgg cag agc acc cgc aac tat ccc cag gtg aac gtg att aac ttc act        480
Arg Gln Ser Thr Arg Asn Tyr Pro Gln Val Asn Val Ile Asn Phe Thr           
145                 150                 155                 160           

aca tcc tgg agc gac ggg ctg gcc ctg aat gct ctg att cac agc cac        528
Thr Ser Trp Ser Asp Gly Leu Ala Leu Asn Ala Leu Ile His Ser His           
                165                 170                 175               

agg cct gat ctg ttc gac tgg aat agc gtg gtg tgc cag cag tct gcc        576
Arg Pro Asp Leu Phe Asp Trp Asn Ser Val Val Cys Gln Gln Ser Ala           
            180                 185                 190                   

aca cag cgc ctg gaa cat gcc ttc aat atc gct cgg tac cag ctg ggg        624
Thr Gln Arg Leu Glu His Ala Phe Asn Ile Ala Arg Tyr Gln Leu Gly           
        195                 200                 205                       

atc gaa aaa ctg ctg gac cca gag gat gtg gac act aca tac cca gat        672
Ile Glu Lys Leu Leu Asp Pro Glu Asp Val Asp Thr Thr Tyr Pro Asp           
    210                 215                 220                           

aaa aag tct att ctg atg tac att act agc ctg ttc cag gtg ctg cca        720
Lys Lys Ser Ile Leu Met Tyr Ile Thr Ser Leu Phe Gln Val Leu Pro           
225                 230                 235                 240           

cag cag gtg tct att gaa gcc att cag gag gtg gaa atg ctg ccc cgc        768
Gln Gln Val Ser Ile Glu Ala Ile Gln Glu Val Glu Met Leu Pro Arg           
                245                 250                 255               

ccc ccc aaa gtg act aaa gag gag cat ttt cag ctg cat cat cag atg        816
Pro Pro Lys Val Thr Lys Glu Glu His Phe Gln Leu His His Gln Met           
            260                 265                 270                   

cat tac agc cag cag att acc gtg agc ctg gct cag gga tat gag cgc        864
His Tyr Ser Gln Gln Ile Thr Val Ser Leu Ala Gln Gly Tyr Glu Arg           
        275                 280                 285                       

acc agt agt cca aaa cca cgg ttc aag tcc tac gct tat acc cag gct        912
Thr Ser Ser Pro Lys Pro Arg Phe Lys Ser Tyr Ala Tyr Thr Gln Ala           
    290                 295                 300                           

gcc tac gtg aca act agc gac cct act aga tcc ccc ttt cca tcc cag        960
Ala Tyr Val Thr Thr Ser Asp Pro Thr Arg Ser Pro Phe Pro Ser Gln           
305                 310                 315                 320           

cac ctg gag gcc cca gag gac aag agc ttt ggg tcc agc ctg atg gaa       1008
His Leu Glu Ala Pro Glu Asp Lys Ser Phe Gly Ser Ser Leu Met Glu           
                325                 330                 335               

agc gag gtg aat ctg gat cgg tac cag aca gcc ctg gag gag gtg ctg       1056
Ser Glu Val Asn Leu Asp Arg Tyr Gln Thr Ala Leu Glu Glu Val Leu           
            340                 345                 350                   

agc tgg ctg ctg agt gct gaa gac aca ctg cag gcc cag ggc gaa att       1104
Ser Trp Leu Leu Ser Ala Glu Asp Thr Leu Gln Ala Gln Gly Glu Ile           
        355                 360                 365                       

tcc aat gac gtg gaa gtg gtg aag gat cag ttc cac aca cac gag ggc       1152
Ser Asn Asp Val Glu Val Val Lys Asp Gln Phe His Thr His Glu Gly           
    370                 375                 380                           

tat atg atg gac ctg aca gct cac cag ggg cgc gtg ggc aat atc ctg       1200
Tyr Met Met Asp Leu Thr Ala His Gln Gly Arg Val Gly Asn Ile Leu           
385                 390                 395                 400           

cag ctg ggc tct aaa ctg atc ggc acc ggg aaa ctg agt gag gac gag       1248
Gln Leu Gly Ser Lys Leu Ile Gly Thr Gly Lys Leu Ser Glu Asp Glu           
                405                 410                 415               

gaa aca gaa gtg cag gag cag atg aac ctg ctg aac agc cgc tgg gag       1296
Glu Thr Glu Val Gln Glu Gln Met Asn Leu Leu Asn Ser Arg Trp Glu           
            420                 425                 430                   

tgt ctg aga gtg gct agt atg gag aag cag tcc aac ctg cac cgg gtg       1344
Cys Leu Arg Val Ala Ser Met Glu Lys Gln Ser Asn Leu His Arg Val           
        435                 440                 445                       

ctg atg gac ctg cag aac cag aaa ctg aaa gag ctg aac gac tgg ctg       1392
Leu Met Asp Leu Gln Asn Gln Lys Leu Lys Glu Leu Asn Asp Trp Leu           
    450                 455                 460                           

aca aag act gag gaa cgc aca agg aag atg gag gag gag cca ctg gga       1440
Thr Lys Thr Glu Glu Arg Thr Arg Lys Met Glu Glu Glu Pro Leu Gly           
465                 470                 475                 480           

ccc gac ctg gag gat ctg aag aga cag gtg cag cag cat aag gtg ctg       1488
Pro Asp Leu Glu Asp Leu Lys Arg Gln Val Gln Gln His Lys Val Leu           
                485                 490                 495               

cag gag gat ctg gaa cag gag cag gtg cgg gtg aac tcc ctg aca cat       1536
Gln Glu Asp Leu Glu Gln Glu Gln Val Arg Val Asn Ser Leu Thr His           
            500                 505                 510                   

atg gtg gtg gtg gtg gac gaa tct agt gga gat cac gcc acc gcc gcc       1584
Met Val Val Val Val Asp Glu Ser Ser Gly Asp His Ala Thr Ala Ala           
        515                 520                 525                       

ctg gag gaa cag ctg aag gtg ctg ggg gac cgg tgg gcc aac att tgc       1632
Leu Glu Glu Gln Leu Lys Val Leu Gly Asp Arg Trp Ala Asn Ile Cys           
    530                 535                 540                           

cgg tgg acc gag gac agg tgg gtg ctg ctg cag gac atc ctg ctg aaa       1680
Arg Trp Thr Glu Asp Arg Trp Val Leu Leu Gln Asp Ile Leu Leu Lys           
545                 550                 555                 560           

tgg cag agg ctg acc gag gag cag tgt ctg ttt agt gct tgg ctg agc       1728
Trp Gln Arg Leu Thr Glu Glu Gln Cys Leu Phe Ser Ala Trp Leu Ser           
                565                 570                 575               

gag aaa gag gac gcc gtg aac aag atc cac aca acc ggc ttt aag gat       1776
Glu Lys Glu Asp Ala Val Asn Lys Ile His Thr Thr Gly Phe Lys Asp           
            580                 585                 590                   

cag aac gaa atg ctg tct agc ctg cag aaa ctg gct gtg ctg aag gcc       1824
Gln Asn Glu Met Leu Ser Ser Leu Gln Lys Leu Ala Val Leu Lys Ala           
        595                 600                 605                       

gat ctg gag aaa aag aag cag agc atg ggc aaa ctg tat agc ctg aaa       1872
Asp Leu Glu Lys Lys Lys Gln Ser Met Gly Lys Leu Tyr Ser Leu Lys           
    610                 615                 620                           

cag gac ctg ctg agc acc ctg aag aac aag agc gtg acc cag aag aca       1920
Gln Asp Leu Leu Ser Thr Leu Lys Asn Lys Ser Val Thr Gln Lys Thr           
625                 630                 635                 640           

gaa gcc tgg ctg gat aac ttt gcc cgc tgc tgg gac aac ctg gtg cag       1968
Glu Ala Trp Leu Asp Asn Phe Ala Arg Cys Trp Asp Asn Leu Val Gln           
                645                 650                 655               

aaa ctg gag aaa agt aca gct cag atc tct cag gct gtg acc aca acc       2016
Lys Leu Glu Lys Ser Thr Ala Gln Ile Ser Gln Ala Val Thr Thr Thr           
            660                 665                 670                   

cag cct agc ctg acc cag aca acc gtg atg gaa acc gtg acc acc gtg       2064
Gln Pro Ser Leu Thr Gln Thr Thr Val Met Glu Thr Val Thr Thr Val           
        675                 680                 685                       

aca acc cgc gaa cag atc ctg gtg aaa cat gcc cag gaa gag ctg cca       2112
Thr Thr Arg Glu Gln Ile Leu Val Lys His Ala Gln Glu Glu Leu Pro           
    690                 695                 700                           

cct cca cct ccc cag aag aag aga acc ctg gag cgg ctg cag gag ctg       2160
Pro Pro Pro Pro Gln Lys Lys Arg Thr Leu Glu Arg Leu Gln Glu Leu           
705                 710                 715                 720           

cag gaa gcc act gac gaa ctg gac ctg aag ctg agg cag gcc gaa gtg       2208
Gln Glu Ala Thr Asp Glu Leu Asp Leu Lys Leu Arg Gln Ala Glu Val           
                725                 730                 735               

att aag ggg tct tgg cag cct gtg ggc gat ctg ctg att gat tcc ctg       2256
Ile Lys Gly Ser Trp Gln Pro Val Gly Asp Leu Leu Ile Asp Ser Leu           
            740                 745                 750                   

cag gac cac ctg gaa aag gtg aag gct ctg aga ggc gaa att gct cca       2304
Gln Asp His Leu Glu Lys Val Lys Ala Leu Arg Gly Glu Ile Ala Pro           
        755                 760                 765                       

ctg aag gag aac gtg agt cat gtg aac gat ctg gct aga cag ctg aca       2352
Leu Lys Glu Asn Val Ser His Val Asn Asp Leu Ala Arg Gln Leu Thr           
    770                 775                 780                           

aca ctg ggc atc cag ctg agc cca tac aat ctg agc aca ctg gag gac       2400
Thr Leu Gly Ile Gln Leu Ser Pro Tyr Asn Leu Ser Thr Leu Glu Asp           
785                 790                 795                 800           

ctg aat acc agg tgg aag ctg ctg cag gtg gct gtg gaa gac cgg gtg       2448
Leu Asn Thr Arg Trp Lys Leu Leu Gln Val Ala Val Glu Asp Arg Val           
                805                 810                 815               

cgg cag ctg cat gag gcc cat cgc gac ttc gga cca gcc agc cag cac       2496
Arg Gln Leu His Glu Ala His Arg Asp Phe Gly Pro Ala Ser Gln His           
            820                 825                 830                   

ttt ctg agc aca tcc gtg cag ggg ccc tgg gag agg gcc att tct ccc       2544
Phe Leu Ser Thr Ser Val Gln Gly Pro Trp Glu Arg Ala Ile Ser Pro           
        835                 840                 845                       

aac aag gtg ccc tac tat att aat cac gag acc cag acc act tgt tgg       2592
Asn Lys Val Pro Tyr Tyr Ile Asn His Glu Thr Gln Thr Thr Cys Trp           
    850                 855                 860                           

gac cat ccc aag atg aca gaa ctg tac cag tcc ctg gcc gat ctg aac       2640
Asp His Pro Lys Met Thr Glu Leu Tyr Gln Ser Leu Ala Asp Leu Asn           
865                 870                 875                 880           

aac gtg agg ttt agc gct tac aga acc gct atg aag ctg aga cgg ctg       2688
Asn Val Arg Phe Ser Ala Tyr Arg Thr Ala Met Lys Leu Arg Arg Leu           
                885                 890                 895               

cag aag gcc ctg tgc ctg gat ctg ctg tcc ctg tcc gcc gcc tgc gat       2736
Gln Lys Ala Leu Cys Leu Asp Leu Leu Ser Leu Ser Ala Ala Cys Asp           
            900                 905                 910                   

gcc ctg gat cag cat aat ctg aag cag aac gat cag cca atg gat atc       2784
Ala Leu Asp Gln His Asn Leu Lys Gln Asn Asp Gln Pro Met Asp Ile           
        915                 920                 925                       

ctg cag atc atc aac tgc ctg acc act atc tac gac agg ctg gag cag       2832
Leu Gln Ile Ile Asn Cys Leu Thr Thr Ile Tyr Asp Arg Leu Glu Gln           
    930                 935                 940                           

gag cac aac aac ctg gtg aac gtg cct ctg tgc gtg gat atg tgc ctg       2880
Glu His Asn Asn Leu Val Asn Val Pro Leu Cys Val Asp Met Cys Leu           
945                 950                 955                 960           

aac tgg ctg ctg aac gtg tat gac act ggg cgc acc ggc cgg atc aga       2928
Asn Trp Leu Leu Asn Val Tyr Asp Thr Gly Arg Thr Gly Arg Ile Arg           
                965                 970                 975               

gtg ctg agt ttt aaa act ggg att atc tcc ctg tgt aag gcc cac ctg       2976
Val Leu Ser Phe Lys Thr Gly Ile Ile Ser Leu Cys Lys Ala His Leu           
            980                 985                 990                   

gag gac aag tac agg tac ctg ttc  aag cag gtg gct agt  agc act gga     3024
Glu Asp Lys Tyr Arg Tyr Leu Phe  Lys Gln Val Ala Ser  Ser Thr Gly         
        995                 1000                 1005                     

ttt tgt  gac cag cgc cgc ctg  gga ctg ctg ctg cat  gat agt atc        3069
Phe Cys  Asp Gln Arg Arg Leu  Gly Leu Leu Leu His  Asp Ser Ile            
    1010                 1015                 1020                        

cag att  cct aga cag ctg gga  gag gtg gct agt ttc  gga gga tct        3114
Gln Ile  Pro Arg Gln Leu Gly  Glu Val Ala Ser Phe  Gly Gly Ser            
    1025                 1030                 1035                        

aac atc  gaa ccc agc gtg cgc  agc tgt ttc cag ttt  gcc aat aac        3159
Asn Ile  Glu Pro Ser Val Arg  Ser Cys Phe Gln Phe  Ala Asn Asn            
    1040                 1045                 1050                        

aaa cct  gaa atc gag gct gct  ctg ttc ctg gat tgg  atg cgc ctg        3204
Lys Pro  Glu Ile Glu Ala Ala  Leu Phe Leu Asp Trp  Met Arg Leu            
    1055                 1060                 1065                        

gaa cca  cag agc atg gtg tgg  ctg cct gtg ctg cac  aga gtg gct        3249
Glu Pro  Gln Ser Met Val Trp  Leu Pro Val Leu His  Arg Val Ala            
    1070                 1075                 1080                        

gcc gcc  gaa act gcc aag cac  cag gct aaa tgc aac  atc tgc aag        3294
Ala Ala  Glu Thr Ala Lys His  Gln Ala Lys Cys Asn  Ile Cys Lys            
    1085                 1090                 1095                        

gaa tgt  ccc att atc ggc ttt  cgc tac agg agt ctg  aaa cat ttt        3339
Glu Cys  Pro Ile Ile Gly Phe  Arg Tyr Arg Ser Leu  Lys His Phe            
    1100                 1105                 1110                        

aac tac  gat att tgc cag agc  tgc ttc ttt tcc gga  aga gtg gcc        3384
Asn Tyr  Asp Ile Cys Gln Ser  Cys Phe Phe Ser Gly  Arg Val Ala            
    1115                 1120                 1125                        

aaa gga  cac aag atg cac tac  cct atg gtg gaa tat  tgc acc cca        3429
Lys Gly  His Lys Met His Tyr  Pro Met Val Glu Tyr  Cys Thr Pro            
    1130                 1135                 1140                        

act aca  tct ggc gaa gat gtg  cgc gat ttt gcc aag  gtg ctg aag        3474
Thr Thr  Ser Gly Glu Asp Val  Arg Asp Phe Ala Lys  Val Leu Lys            
    1145                 1150                 1155                        

aat aag  ttt cgg act aag agg  tac ttc gcc aag cac  ccc cgc atg        3519
Asn Lys  Phe Arg Thr Lys Arg  Tyr Phe Ala Lys His  Pro Arg Met            
    1160                 1165                 1170                        

ggg tat  ctg cca gtg cag aca  gtg ctg gaa gga gac  aat atg gag        3564
Gly Tyr  Leu Pro Val Gln Thr  Val Leu Glu Gly Asp  Asn Met Glu            
    1175                 1180                 1185                        

acc gat  aca atg tga gc                                               3581
Thr Asp  Thr Met                                                          
    1190                                                                  


<210>  8
<211>  1192
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Leu Trp Trp Glu Glu Val Glu Asp Cys Tyr Glu Arg Glu Asp Val 
1               5                   10                  15      


Gln Lys Lys Thr Phe Thr Lys Trp Val Asn Ala Gln Phe Ser Lys Phe 
            20                  25                  30          


Gly Lys Gln His Ile Glu Asn Leu Phe Ser Asp Leu Gln Asp Gly Arg 
        35                  40                  45              


Arg Leu Leu Asp Leu Leu Glu Gly Leu Thr Gly Gln Lys Leu Pro Lys 
    50                  55                  60                  


Glu Lys Gly Ser Thr Arg Val His Ala Leu Asn Asn Val Asn Lys Ala 
65                  70                  75                  80  


Leu Arg Val Leu Gln Asn Asn Asn Val Asp Leu Val Asn Ile Gly Ser 
                85                  90                  95      


Thr Asp Ile Val Asp Gly Asn His Lys Leu Thr Leu Gly Leu Ile Trp 
            100                 105                 110         


Asn Ile Ile Leu His Trp Gln Val Lys Asn Val Met Lys Asn Ile Met 
        115                 120                 125             


Ala Gly Leu Gln Gln Thr Asn Ser Glu Lys Ile Leu Leu Ser Trp Val 
    130                 135                 140                 


Arg Gln Ser Thr Arg Asn Tyr Pro Gln Val Asn Val Ile Asn Phe Thr 
145                 150                 155                 160 


Thr Ser Trp Ser Asp Gly Leu Ala Leu Asn Ala Leu Ile His Ser His 
                165                 170                 175     


Arg Pro Asp Leu Phe Asp Trp Asn Ser Val Val Cys Gln Gln Ser Ala 
            180                 185                 190         


Thr Gln Arg Leu Glu His Ala Phe Asn Ile Ala Arg Tyr Gln Leu Gly 
        195                 200                 205             


Ile Glu Lys Leu Leu Asp Pro Glu Asp Val Asp Thr Thr Tyr Pro Asp 
    210                 215                 220                 


Lys Lys Ser Ile Leu Met Tyr Ile Thr Ser Leu Phe Gln Val Leu Pro 
225                 230                 235                 240 


Gln Gln Val Ser Ile Glu Ala Ile Gln Glu Val Glu Met Leu Pro Arg 
                245                 250                 255     


Pro Pro Lys Val Thr Lys Glu Glu His Phe Gln Leu His His Gln Met 
            260                 265                 270         


His Tyr Ser Gln Gln Ile Thr Val Ser Leu Ala Gln Gly Tyr Glu Arg 
        275                 280                 285             


Thr Ser Ser Pro Lys Pro Arg Phe Lys Ser Tyr Ala Tyr Thr Gln Ala 
    290                 295                 300                 


Ala Tyr Val Thr Thr Ser Asp Pro Thr Arg Ser Pro Phe Pro Ser Gln 
305                 310                 315                 320 


His Leu Glu Ala Pro Glu Asp Lys Ser Phe Gly Ser Ser Leu Met Glu 
                325                 330                 335     


Ser Glu Val Asn Leu Asp Arg Tyr Gln Thr Ala Leu Glu Glu Val Leu 
            340                 345                 350         


Ser Trp Leu Leu Ser Ala Glu Asp Thr Leu Gln Ala Gln Gly Glu Ile 
        355                 360                 365             


Ser Asn Asp Val Glu Val Val Lys Asp Gln Phe His Thr His Glu Gly 
    370                 375                 380                 


Tyr Met Met Asp Leu Thr Ala His Gln Gly Arg Val Gly Asn Ile Leu 
385                 390                 395                 400 


Gln Leu Gly Ser Lys Leu Ile Gly Thr Gly Lys Leu Ser Glu Asp Glu 
                405                 410                 415     


Glu Thr Glu Val Gln Glu Gln Met Asn Leu Leu Asn Ser Arg Trp Glu 
            420                 425                 430         


Cys Leu Arg Val Ala Ser Met Glu Lys Gln Ser Asn Leu His Arg Val 
        435                 440                 445             


Leu Met Asp Leu Gln Asn Gln Lys Leu Lys Glu Leu Asn Asp Trp Leu 
    450                 455                 460                 


Thr Lys Thr Glu Glu Arg Thr Arg Lys Met Glu Glu Glu Pro Leu Gly 
465                 470                 475                 480 


Pro Asp Leu Glu Asp Leu Lys Arg Gln Val Gln Gln His Lys Val Leu 
                485                 490                 495     


Gln Glu Asp Leu Glu Gln Glu Gln Val Arg Val Asn Ser Leu Thr His 
            500                 505                 510         


Met Val Val Val Val Asp Glu Ser Ser Gly Asp His Ala Thr Ala Ala 
        515                 520                 525             


Leu Glu Glu Gln Leu Lys Val Leu Gly Asp Arg Trp Ala Asn Ile Cys 
    530                 535                 540                 


Arg Trp Thr Glu Asp Arg Trp Val Leu Leu Gln Asp Ile Leu Leu Lys 
545                 550                 555                 560 


Trp Gln Arg Leu Thr Glu Glu Gln Cys Leu Phe Ser Ala Trp Leu Ser 
                565                 570                 575     


Glu Lys Glu Asp Ala Val Asn Lys Ile His Thr Thr Gly Phe Lys Asp 
            580                 585                 590         


Gln Asn Glu Met Leu Ser Ser Leu Gln Lys Leu Ala Val Leu Lys Ala 
        595                 600                 605             


Asp Leu Glu Lys Lys Lys Gln Ser Met Gly Lys Leu Tyr Ser Leu Lys 
    610                 615                 620                 


Gln Asp Leu Leu Ser Thr Leu Lys Asn Lys Ser Val Thr Gln Lys Thr 
625                 630                 635                 640 


Glu Ala Trp Leu Asp Asn Phe Ala Arg Cys Trp Asp Asn Leu Val Gln 
                645                 650                 655     


Lys Leu Glu Lys Ser Thr Ala Gln Ile Ser Gln Ala Val Thr Thr Thr 
            660                 665                 670         


Gln Pro Ser Leu Thr Gln Thr Thr Val Met Glu Thr Val Thr Thr Val 
        675                 680                 685             


Thr Thr Arg Glu Gln Ile Leu Val Lys His Ala Gln Glu Glu Leu Pro 
    690                 695                 700                 


Pro Pro Pro Pro Gln Lys Lys Arg Thr Leu Glu Arg Leu Gln Glu Leu 
705                 710                 715                 720 


Gln Glu Ala Thr Asp Glu Leu Asp Leu Lys Leu Arg Gln Ala Glu Val 
                725                 730                 735     


Ile Lys Gly Ser Trp Gln Pro Val Gly Asp Leu Leu Ile Asp Ser Leu 
            740                 745                 750         


Gln Asp His Leu Glu Lys Val Lys Ala Leu Arg Gly Glu Ile Ala Pro 
        755                 760                 765             


Leu Lys Glu Asn Val Ser His Val Asn Asp Leu Ala Arg Gln Leu Thr 
    770                 775                 780                 


Thr Leu Gly Ile Gln Leu Ser Pro Tyr Asn Leu Ser Thr Leu Glu Asp 
785                 790                 795                 800 


Leu Asn Thr Arg Trp Lys Leu Leu Gln Val Ala Val Glu Asp Arg Val 
                805                 810                 815     


Arg Gln Leu His Glu Ala His Arg Asp Phe Gly Pro Ala Ser Gln His 
            820                 825                 830         


Phe Leu Ser Thr Ser Val Gln Gly Pro Trp Glu Arg Ala Ile Ser Pro 
        835                 840                 845             


Asn Lys Val Pro Tyr Tyr Ile Asn His Glu Thr Gln Thr Thr Cys Trp 
    850                 855                 860                 


Asp His Pro Lys Met Thr Glu Leu Tyr Gln Ser Leu Ala Asp Leu Asn 
865                 870                 875                 880 


Asn Val Arg Phe Ser Ala Tyr Arg Thr Ala Met Lys Leu Arg Arg Leu 
                885                 890                 895     


Gln Lys Ala Leu Cys Leu Asp Leu Leu Ser Leu Ser Ala Ala Cys Asp 
            900                 905                 910         


Ala Leu Asp Gln His Asn Leu Lys Gln Asn Asp Gln Pro Met Asp Ile 
        915                 920                 925             


Leu Gln Ile Ile Asn Cys Leu Thr Thr Ile Tyr Asp Arg Leu Glu Gln 
    930                 935                 940                 


Glu His Asn Asn Leu Val Asn Val Pro Leu Cys Val Asp Met Cys Leu 
945                 950                 955                 960 


Asn Trp Leu Leu Asn Val Tyr Asp Thr Gly Arg Thr Gly Arg Ile Arg 
                965                 970                 975     


Val Leu Ser Phe Lys Thr Gly Ile Ile Ser Leu Cys Lys Ala His Leu 
            980                 985                 990         


Glu Asp Lys Tyr Arg Tyr Leu Phe  Lys Gln Val Ala Ser  Ser Thr Gly 
        995                 1000                 1005             


Phe Cys  Asp Gln Arg Arg Leu  Gly Leu Leu Leu His  Asp Ser Ile 
    1010                 1015                 1020             


Gln Ile  Pro Arg Gln Leu Gly  Glu Val Ala Ser Phe  Gly Gly Ser 
    1025                 1030                 1035             


Asn Ile  Glu Pro Ser Val Arg  Ser Cys Phe Gln Phe  Ala Asn Asn 
    1040                 1045                 1050             


Lys Pro  Glu Ile Glu Ala Ala  Leu Phe Leu Asp Trp  Met Arg Leu 
    1055                 1060                 1065             


Glu Pro  Gln Ser Met Val Trp  Leu Pro Val Leu His  Arg Val Ala 
    1070                 1075                 1080             


Ala Ala  Glu Thr Ala Lys His  Gln Ala Lys Cys Asn  Ile Cys Lys 
    1085                 1090                 1095             


Glu Cys  Pro Ile Ile Gly Phe  Arg Tyr Arg Ser Leu  Lys His Phe 
    1100                 1105                 1110             


Asn Tyr  Asp Ile Cys Gln Ser  Cys Phe Phe Ser Gly  Arg Val Ala 
    1115                 1120                 1125             


Lys Gly  His Lys Met His Tyr  Pro Met Val Glu Tyr  Cys Thr Pro 
    1130                 1135                 1140             


Thr Thr  Ser Gly Glu Asp Val  Arg Asp Phe Ala Lys  Val Leu Lys 
    1145                 1150                 1155             


Asn Lys  Phe Arg Thr Lys Arg  Tyr Phe Ala Lys His  Pro Arg Met 
    1160                 1165                 1170             


Gly Tyr  Leu Pro Val Gln Thr  Val Leu Glu Gly Asp  Asn Met Glu 
    1175                 1180                 1185             


Thr Asp  Thr Met 
    1190         


<210>  9
<211>  8409
<212>  DNA
<213>  Adeno-associated virus


<220>
<221>  promoter
<222>  (236)..(799)
<223>  MCK promotor

<220>
<221>  Intron
<222>  (844)..(993)
<223>  Chimeric intron sequence

<220>
<221>  misc_feature
<222>  (1004)..(4584)
<223>  Human Dystrophin sequence

<220>
<221>  misc_feature
<222>  (4585)..(4640)
<223>  Poly A tail

<220>
<221>  misc_feature
<222>  (6606)..(7466)
<223>  Ampicillin resistance

<220>
<221>  misc_feature
<222>  (7621)..(8240)
<223>  pGEX plasmid backbone with pBR322 origin or replication

<400>  9
gcccaatacg caaaccgcct ctccccgcgc gttggccgat tcattaatgc agctggcgcg       60

ctcgctcgct cactgaggcc gcccgggcaa agcccgggcg tcgggcgacc tttggtcgcc      120

cggcctcagt gagcgagcga gcgcgcagag agggagtggc caactccatc actaggggtt      180

ccttgtagtt aatgattaac ccgccatgct aattatctac gtagccatgt ctagacagcc      240

actatgggtc taggctgccc atgtaaggag gcaaggcctg gggacacccg agatgcctgg      300

ttataattaa cccagacatg tggctgctcc ccccccccaa cacctgctgc ctgagcctca      360

cccccacccc ggtgcctggg tcttaggctc tgtacaccat ggaggagaag ctcgctctaa      420

aaataaccct gtccctggtg ggctgtgggg gactgagggc aggctgtaac aggcttgggg      480

gccagggctt atacgtgcct gggactccca aagtattact gttccatgtt cccggcgaag      540

ggccagctgt cccccgccag ctagactcag cacttagttt aggaaccagt gagcaagtca      600

gcccttgggg cagcccatac aaggccatgg ggctgggcaa gctgcacgcc tgggtccggg      660

gtgggcacgg tgcccgggca acgagctgaa agctcatctg ctctcagggg cccctccctg      720

gggacagccc ctcctggcta gtcacaccct gtaggctcct ctatataacc caggggcaca      780

ggggctgccc ccgggtcacc accacctcca cagcacagac agacactcag gagccagcca      840

gccaggtaag tttagtcttt ttgtctttta tttcaggtcc cggatccggt ggtggtgcaa      900

atcaaagaac tgctcctcag tggatgttgc ctttacttct aggcctgtac ggaagtgtta      960

cttctgctct aaaagctgcg gaattgtacc cgcggccgcc accatgctgt ggtgggagga     1020

ggtggaggat tgttatgaaa gggaggacgt gcagaagaag acttttacca agtgggtgaa     1080

cgctcagttc agcaaatttg ggaagcagca catcgagaat ctgttttccg acctgcagga     1140

tgggagacgg ctgctggatc tgctggaagg actgactggc cagaagctgc ccaaagagaa     1200

ggggagcact agggtgcacg ccctgaacaa cgtgaacaaa gctctgagag tgctgcagaa     1260

caacaacgtg gatctggtga atattggcag tactgatatc gtggacggga accacaaact     1320

gacactgggc ctgatctgga acattattct gcactggcag gtgaaaaatg tgatgaagaa     1380

catcatggcc gggctgcagc agaccaattc cgagaagatc ctgctgtctt gggtgcggca     1440

gagcacccgc aactatcccc aggtgaacgt gattaacttc actacatcct ggagcgacgg     1500

gctggccctg aatgctctga ttcacagcca caggcctgat ctgttcgact ggaatagcgt     1560

ggtgtgccag cagtctgcca cacagcgcct ggaacatgcc ttcaatatcg ctcggtacca     1620

gctggggatc gaaaaactgc tggacccaga ggatgtggac actacatacc cagataaaaa     1680

gtctattctg atgtacatta ctagcctgtt ccaggtgctg ccacagcagg tgtctattga     1740

agccattcag gaggtggaaa tgctgccccg cccccccaaa gtgactaaag aggagcattt     1800

tcagctgcat catcagatgc attacagcca gcagattacc gtgagcctgg ctcagggata     1860

tgagcgcacc agtagtccaa aaccacggtt caagtcctac gcttataccc aggctgccta     1920

cgtgacaact agcgacccta ctagatcccc ctttccatcc cagcacctgg aggccccaga     1980

ggacaagagc tttgggtcca gcctgatgga aagcgaggtg aatctggatc ggtaccagac     2040

agccctggag gaggtgctga gctggctgct gagtgctgaa gacacactgc aggcccaggg     2100

cgaaatttcc aatgacgtgg aagtggtgaa ggatcagttc cacacacacg agggctatat     2160

gatggacctg acagctcacc aggggcgcgt gggcaatatc ctgcagctgg gctctaaact     2220

gatcggcacc gggaaactga gtgaggacga ggaaacagaa gtgcaggagc agatgaacct     2280

gctgaacagc cgctgggagt gtctgagagt ggctagtatg gagaagcagt ccaacctgca     2340

ccgggtgctg atggacctgc agaaccagaa actgaaagag ctgaacgact ggctgacaaa     2400

gactgaggaa cgcacaagga agatggagga ggagccactg ggacccgacc tggaggatct     2460

gaagagacag gtgcagcagc ataaggtgct gcaggaggat ctggaacagg agcaggtgcg     2520

ggtgaactcc ctgacacata tggtggtggt ggtggacgaa tctagtggag atcacgccac     2580

cgccgccctg gaggaacagc tgaaggtgct gggggaccgg tgggccaaca tttgccggtg     2640

gaccgaggac aggtgggtgc tgctgcagga catcctgctg aaatggcaga ggctgaccga     2700

ggagcagtgt ctgtttagtg cttggctgag cgagaaagag gacgccgtga acaagatcca     2760

cacaaccggc tttaaggatc agaacgaaat gctgtctagc ctgcagaaac tggctgtgct     2820

gaaggccgat ctggagaaaa agaagcagag catgggcaaa ctgtatagcc tgaaacagga     2880

cctgctgagc accctgaaga acaagagcgt gacccagaag acagaagcct ggctggataa     2940

ctttgcccgc tgctgggaca acctggtgca gaaactggag aaaagtacag ctcagatctc     3000

tcaggctgtg accacaaccc agcctagcct gacccagaca accgtgatgg aaaccgtgac     3060

caccgtgaca acccgcgaac agatcctggt gaaacatgcc caggaagagc tgccacctcc     3120

acctccccag aagaagagaa ccctggagcg gctgcaggag ctgcaggaag ccactgacga     3180

actggacctg aagctgaggc aggccgaagt gattaagggg tcttggcagc ctgtgggcga     3240

tctgctgatt gattccctgc aggaccacct ggaaaaggtg aaggctctga gaggcgaaat     3300

tgctccactg aaggagaacg tgagtcatgt gaacgatctg gctagacagc tgacaacact     3360

gggcatccag ctgagcccat acaatctgag cacactggag gacctgaata ccaggtggaa     3420

gctgctgcag gtggctgtgg aagaccgggt gcggcagctg catgaggccc atcgcgactt     3480

cggaccagcc agccagcact ttctgagcac atccgtgcag gggccctggg agagggccat     3540

ttctcccaac aaggtgccct actatattaa tcacgagacc cagaccactt gttgggacca     3600

tcccaagatg acagaactgt accagtccct ggccgatctg aacaacgtga ggtttagcgc     3660

ttacagaacc gctatgaagc tgagacggct gcagaaggcc ctgtgcctgg atctgctgtc     3720

cctgtccgcc gcctgcgatg ccctggatca gcataatctg aagcagaacg atcagccaat     3780

ggatatcctg cagatcatca actgcctgac cactatctac gacaggctgg agcaggagca     3840

caacaacctg gtgaacgtgc ctctgtgcgt ggatatgtgc ctgaactggc tgctgaacgt     3900

gtatgacact gggcgcaccg gccggatcag agtgctgagt tttaaaactg ggattatctc     3960

cctgtgtaag gcccacctgg aggacaagta caggtacctg ttcaagcagg tggctagtag     4020

cactggattt tgtgaccagc gccgcctggg actgctgctg catgatagta tccagattcc     4080

tagacagctg ggagaggtgg ctagtttcgg aggatctaac atcgaaccca gcgtgcgcag     4140

ctgtttccag tttgccaata acaaacctga aatcgaggct gctctgttcc tggattggat     4200

gcgcctggaa ccacagagca tggtgtggct gcctgtgctg cacagagtgg ctgccgccga     4260

aactgccaag caccaggcta aatgcaacat ctgcaaggaa tgtcccatta tcggctttcg     4320

ctacaggagt ctgaaacatt ttaactacga tatttgccag agctgcttct tttccggaag     4380

agtggccaaa ggacacaaga tgcactaccc tatggtggaa tattgcaccc caactacatc     4440

tggcgaagat gtgcgcgatt ttgccaaggt gctgaagaat aagtttcgga ctaagaggta     4500

cttcgccaag cacccccgca tggggtatct gccagtgcag acagtgctgg aaggagacaa     4560

tatggagacc gatacaatgt gagcggccgc aataaaagat ctttattttc attagatctg     4620

tgtgttggtt ttttgtgtgt ctagagcatg gctacgtaga taagtagcat ggcgggttaa     4680

tcattaacta caaggaaccc ctagtgatgg agttggccac tccctctctg cgcgctcgct     4740

cgctcactga ggccgggcga ccaaaggtcg cccgacgccc gggctttgcc cgggcggcct     4800

cagtgagcga gcgagcgcgc cagctggcgt aatagcgaag aggcccgcac cgatcgccct     4860

tcccaacagt tgcgcagcct gaatggcgaa tggaagttcc agacgattga gcgtcaaaat     4920

gtaggtattt ccatgagcgt ttttcctgtt gcaatggctg gcggtaatat tgttctggat     4980

attaccagca aggccgatag tttgagttct tctactcagg caagtgatgt tattactaat     5040

caaagaagta ttgcgacaac ggttaatttg cgtgatggac agactctttt actcggtggc     5100

ctcactgatt ataaaaacac ttctcaggat tctggcgtac cgttcctgtc taaaatccct     5160

ttaatcggcc tcctgtttag ctcccgctct gattctaacg aggaaagcac gttatacgtg     5220

ctcgtcaaag caaccatagt acgcgccctg tagcggcgca ttaagcgcgg cgggtgtggt     5280

ggttacgcgc agcgtgaccg ctacacttgc cagcgcccta gcgcccgctc ctttcgcttt     5340

cttcccttcc tttctcgcca cgttcgccgg ctttccccgt caagctctaa atcgggggct     5400

ccctttaggg ttccgattta gtgatttacg gcacctcgac cccaaaaaac ttgattaggg     5460

tgatggttca cgtagtgggc catcgccctg atagacggtt tttcgccctt tgacgttgga     5520

gtccacgttc tttaatagtg gactcttgtt ccaaactgga acaacactca accctatctc     5580

ggtctattct tttgatttat aagggatttt gccgatttcg gcctattggt taaaaaatga     5640

gctgatttaa caaaaattta acgcgaattt taacaaaata ttaacgttta caatttaaat     5700

atttgcttat acaatcttcc tgtttttggg gcttttctga ttatcaaccg gggtacatat     5760

gattgacatg ctagttttac gattaccgtt catcgattct cttgtttgct ccagactctc     5820

aggcaatgac ctgatagcct ttgtagagac ctctcaaaaa tagctaccct ctccggcatg     5880

aatttatcag ctagaacggt tgaatatcat attgatggtg atttgactgt ctccggcctt     5940

tctcacccgt ttgaatcttt acctacacat tactcaggca ttgcatttaa aatatatgag     6000

ggttctaaaa atttttatcc ttgcgttgaa ataaaggctt ctcccgcaaa agtattacag     6060

ggtcataatg tttttggtac aaccgattta gctttatgct ctgaggcttt attgcttaat     6120

tttgctaatt ctttgccttg cctgtatgat ttattggatg ttggaagttc ctgatgcggt     6180

attttctcct tacgcatctg tgcggtattt cacaccgcat atggtgcact ctcagtacaa     6240

tctgctctga tgccgcatag ttaagccagc cccgacaccc gccaacaccc gctgacgcgc     6300

cctgacgggc ttgtctgctc ccggcatccg cttacagaca agctgtgacc gtctccggga     6360

gctgcatgtg tcagaggttt tcaccgtcat caccgaaacg cgcgagacga aagggcctcg     6420

tgatacgcct atttttatag gttaatgtca tgataataat ggtttcttag acgtcaggtg     6480

gcacttttcg gggaaatgtg cgcggaaccc ctatttgttt atttttctaa atacattcaa     6540

atatgtatcc gctcatgaga caataaccct gataaatgct tcaataatat tgaaaaagga     6600

agagtatgag tattcaacat ttccgtgtcg cccttattcc cttttttgcg gcattttgcc     6660

ttcctgtttt tgctcaccca gaaacgctgg tgaaagtaaa agatgctgaa gatcagttgg     6720

gtgcacgagt gggttacatc gaactggatc tcaacagcgg taagatcctt gagagttttc     6780

gccccgaaga acgttttcca atgatgagca cttttaaagt tctgctatgt ggcgcggtat     6840

tatcccgtat tgacgccggg caagagcaac tcggtcgccg catacactat tctcagaatg     6900

acttggttga gtactcacca gtcacagaaa agcatcttac ggatggcatg acagtaagag     6960

aattatgcag tgctgccata accatgagtg ataacactgc ggccaactta cttctgacaa     7020

cgatcggagg accgaaggag ctaaccgctt ttttgcacaa catgggggat catgtaactc     7080

gccttgatcg ttgggaaccg gagctgaatg aagccatacc aaacgacgag cgtgacacca     7140

cgatgcctgt agcaatggca acaacgttgc gcaaactatt aactggcgaa ctacttactc     7200

tagcttcccg gcaacaatta atagactgga tggaggcgga taaagttgca ggaccacttc     7260

tgcgctcggc ccttccggct ggctggttta ttgctgataa atctggagcc ggtgagcgtg     7320

ggtctcgcgg tatcattgca gcactggggc cagatggtaa gccctcccgt atcgtagtta     7380

tctacacgac ggggagtcag gcaactatgg atgaacgaaa tagacagatc gctgagatag     7440

gtgcctcact gattaagcat tggtaactgt cagaccaagt ttactcatat atactttaga     7500

ttgatttaaa acttcatttt taatttaaaa ggatctaggt gaagatcctt tttgataatc     7560

tcatgaccaa aatcccttaa cgtgagtttt cgttccactg agcgtcagac cccgtagaaa     7620

agatcaaagg atcttcttga gatccttttt ttctgcgcgt aatctgctgc ttgcaaacaa     7680

aaaaaccacc gctaccagcg gtggtttgtt tgccggatca agagctacca actctttttc     7740

cgaaggtaac tggcttcagc agagcgcaga taccaaatac tgtccttcta gtgtagccgt     7800

agttaggcca ccacttcaag aactctgtag caccgcgtac atacctcgct ctgctaatcc     7860

tgttaccagt ggctgctgcc agtggcgata agtcgtgtct taccgggttg gactcaagac     7920

gatagttacc ggataaggcg cagcggtcgg gctgaacggg gggttcgtgc acacagccca     7980

gcttggagcg aacgacctac accgaactga gatacctaca gcgtgagcta tgagaaagcg     8040

ccacgcttcc cgaagggaga aaggcggaca ggtatccggt aagcggcagg gtcggaacag     8100

gagagcgcac gagggagctt ccagggggaa acgcctggta tctttatagt cctgtcgggt     8160

ttcgccacct ctgacttgag cgtcgatttt tgtgatgctc gtcagggggg cggagcctat     8220

ggaaaaacgc cagcaacgcg gcctttttac ggttcctggc cttttgctgg ccttttgctc     8280

acatgttctt tcctgcgtta tcccctgatt ctgtggataa ccgtattacc gggtttgagt     8340

gagctgatac cgctcgccgc agccgaacga ccgagcgcag cgagtcagtg agcgaccaag     8400

cggaagagc                                                             8409


<210>  10
<211>  206
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  enhancer
<222>  (1)..(206)
<223>  MCK enhancer

<400>  10
cagccactat gggtctaggc tgcccatgta aggaggcaag gcctggggac acccgagatg       60

cctggttata attaacccag acatgtggct gctccccccc cccaacacct gctgcctgag      120

cctcaccccc accccggtgc ctgggtctta ggctctgtac accatggagg agaagctcgc      180

tctaaaaata accctgtccc tggtgg                                           206


<210>  11
<211>  358
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  promoter
<222>  (1)..(358)
<223>  MCK promoter

<400>  11
gctgtggggg actgagggca ggctgtaaca ggcttggggg ccagggctta tacgtgcctg       60

ggactcccaa agtattactg ttccatgttc ccggcgaagg gccagctgtc ccccgccagc      120

tagactcagc acttagttta ggaaccagtg agcaagtcag cccttggggc agcccataca      180

aggccatggg gctgggcaag ctgcacgcct gggtccgggg tgggcacggt gcccgggcaa      240

cgagctgaaa gctcatctgc tctcaggggc ccctccctgg ggacagcccc tcctggctag      300

tcacaccctg taggctcctc tatataaccc aggggcacag gggctgcccc cgggtcac        358


<210>  12
<211>  5920
<212>  DNA
<213>  Adeno-associated virus


<220>
<221>  misc_feature
<223>  pAAV.MCK.miR26C Sequence

<220>
<221>  misc_feature
<222>  (4)..(9)
<223>  n is a, c, g, t or u

<220>
<221>  enhancer
<222>  (190)..(395)
<223>  MCK enhancer

<220>
<221>  promoter
<222>  (396)..(753)
<223>  MCK promoter

<220>
<221>  misc_feature
<222>  (1316)..(1608)
<223>  shRNA-miR29-c with primary seed sequence

<220>
<221>  misc_feature
<222>  (1487)..(1512)
<223>  miR-29c

<220>
<221>  misc_feature
<222>  (2094)..(2146)
<223>  SV40 PolyA

<220>
<221>  misc_feature
<222>  (2326)..(2331)
<223>  n is a, c, g, t or u

<400>  12
ctgnnnnnng cgcgctcgct cgctcactga ggccgcccgg gcaaagcccg ggcgtcgggc       60

gacctttggt cgcccggcct cagtgagcga gcgagcgcgc agagagggag tggccaactc      120

catcactagg ggttccttgt agttaatgat taacccgcca tgctaattat ctacgtagcc      180

atgtctagac agccactatg ggtctaggct gcccatgtaa ggaggcaagg cctggggaca      240

cccgagatgc ctggttataa ttaacccaga catgtggctg ctcccccccc ccaacacctg      300

ctgcctgagc ctcaccccca ccccggtgcc tgggtcttag gctctgtaca ccatggagga      360

gaagctcgct ctaaaaataa ccctgtccct ggtgggctgt gggggactga gggcaggctg      420

taacaggctt gggggccagg gcttatacgt gcctgggact cccaaagtat tactgttcca      480

tgttcccggc gaagggccag ctgtcccccg ccagctagac tcagcactta gtttaggaac      540

cagtgagcaa gtcagccctt ggggcagccc atacaaggcc atggggctgg gcaagctgca      600

cgcctgggtc cggggtgggc acggtgcccg ggcaacgagc tgaaagctca tctgctctca      660

ggggcccctc cctggggaca gcccctcctg gctagtcaca ccctgtaggc tcctctatat      720

aacccagggg cacaggggct gcccccgggt caccaccacc tccacagcac agacagacac      780

tcaggagcca gccagccagg taagtttagt ctttttgtct tttatttcag gtcccggatc      840

cggtggtggt gcaaatcaaa gaactgctcc tcagtggatg ttgcctttac ttctaggcct      900

gtacggaagt gttacttctg ctctaaaagc tgcggaattg tacccgccta gaggatccgg      960

tactcgagga actgaaaaac cagaaagtta actggtaagt ttagtctttt tgtcttttat     1020

ttcaggtccc ggatccggtg gtggtgcaaa tcaaagaact gctcctcagt ggatgttgcc     1080

tttacttcta ggcctgtacg gaagtgttac ttctgctcta aaagctgcgg aattgtaccc     1140

ggggccgatc caccggtctt tttcgcaacg ggtttgccgc cagaacacag gtaagtgccg     1200

tgtgtggttc ccgcgggcgg cgacggggcc cgtgcgtccc agcgcacatg ttcggcgagg     1260

cggggcctgc gagcgcggcc accgagaatc ggacgggggt agtctcaagc tggccggcct     1320

gtttgaatga ggcttcagta ctttacagaa tcgttgcctg cacatcttgg aaacacttgc     1380

tgggattact tcttcaggtt aacccaacag aaggctcgag aaggtatatt gctgttgaca     1440

gtgagcgcaa ccgatttcaa atggtgctag agtgaagcca cagatgtcta gcaccatttg     1500

aaatcggtta tgcctactgc ctcggaattc aaggggctac tttaggagca attatcttgt     1560

ttactaaaac tgaatacctt gctatctctt tgatacattg gccggcctgc tctggtgcct     1620

ggcctcgcgc cgccgtgtat cgccccgccc tgggcggcaa ggctggcccg gtcggcacca     1680

gttgcgtgag cggaaagatg gccgcttccc ggccctgctg cagggagctc aaaatggagg     1740

acgcggcgct cgggagagcg ggcgggtgag tcacccacac aaaggaaaag ggcctttccg     1800

tcctcagccg tcgcttcatg tgactccacg gagtaccggg cgccgtccag gcacctcgat     1860

tagttctcga gcttttggag tacgtcgtct ttaggttggg gggaggggtt ttatgcgatg     1920

gagtttcccc acactgagtg ggtggagact gaagttaggc cagcttggca cttgatgtaa     1980

ttctccttgg aatttgccct ttttgagttt ggatcttggt tcattctcaa gcctcagaca     2040

gtggttcaaa gtttttttct tccatttcag gtgtcgtgaa aagctagtgc ggccgcaata     2100

aaagatcttt attttcatta gatctgtgtg ttggtttttt gtgtgtctag acatggctac     2160

gtagataatt agcatggcgg gttaatcatt aactacaagg aacccctagt gatggagttg     2220

gccactccct ctctgcgcgc tcgctcgctc actgaggccg ggcgaccaaa ggtcgcccga     2280

cgcccgggct ttgcccgggc ggcctcagtg agcgagcgag cgcgcnnnnn ncagctggcg     2340

taatagcgaa gaggcccgca ccgatcgccc ttcccaacag ttgcgcagcc tgaatggcga     2400

atggaagttc cagacgattg agcgtcaaaa tgtaggtatt tccatgagcg tttttcctgt     2460

tgcaatggct ggcggtaata ttgttctgga tattaccagc aaggccgata gtttgagttc     2520

ttctactcag gcaagtgatg ttattactaa tcaaagaagt attgcgacaa cggttaattt     2580

gcgtgatgga cagactcttt tactcggtgg cctcactgat tataaaaaca cttctcagga     2640

ttctggcgta ccgttcctgt ctaaaatccc tttaatcggc ctcctgttta gctcccgctc     2700

tgattctaac gaggaaagca cgttatacgt gctcgtcaaa gcaaccatag tacgcgccct     2760

gtagcggcgc attaagcgcg gcgggtgtgg tggttacgcg cagcgtgacc gctacacttg     2820

ccagcgccct agcgcccgct cctttcgctt tcttcccttc ctttctcgcc acgttcgccg     2880

gctttccccg tcaagctcta aatcgggggc tccctttagg gttccgattt agtgatttac     2940

ggcacctcga ccccaaaaaa cttgattagg gtgatggttc acgtagtggg ccatcgccct     3000

gatagacggt ttttcgccct ttgacgttgg agtccacgtt ctttaatagt ggactcttgt     3060

tccaaactgg aacaacactc aaccctatct cggtctattc ttttgattta taagggattt     3120

tgccgatttc ggcctattgg ttaaaaaatg agctgattta acaaaaattt aacgcgaatt     3180

ttaacaaaat attaacgttt acaatttaaa tatttgctta tacaatcttc ctgtttttgg     3240

ggcttttctg attatcaacc ggggtacata tgattgacat gctagtttta cgattaccgt     3300

tcatcgattc tcttgtttgc tccagactct caggcaatga cctgatagcc tttgtagaga     3360

cctctcaaaa atagctaccc tctccggcat gaatttatca gctagaacgg ttgaatatca     3420

tattgatggt gatttgactg tctccggcct ttctcacccg tttgaatctt tacctacaca     3480

ttactcaggc attgcattta aaatatatga gggttctaaa aatttttatc cttgcgttga     3540

aataaaggct tctcccgcaa aagtattaca gggtcataat gtttttggta caaccgattt     3600

agctttatgc tctgaggctt tattgcttaa ttttgctaat tctttgcctt gcctgtatga     3660

tttattggat gttggaagtt cctgatgcgg tattttctcc ttacgcatct gtgcggtatt     3720

tcacaccgca tatggtgcac tctcagtaca atctgctctg atgccgcata gttaagccag     3780

ccccgacacc cgccaacacc cgctgacgcg ccctgacggg cttgtctgct cccggcatcc     3840

gcttacagac aagctgtgac cgtctccggg agctgcatgt gtcagaggtt ttcaccgtca     3900

tcaccgaaac gcgcgagacg aaagggcctc gtgatacgcc tatttttata ggttaatgtc     3960

atgataataa tggtttctta gacgtcaggt ggcacttttc ggggaaatgt gcgcggaacc     4020

cctatttgtt tatttttcta aatacattca aatatgtatc cgctcatgag acaataaccc     4080

tgataaatgc ttcaataata ttgaaaaagg aagagtatga gtattcaaca tttccgtgtc     4140

gcccttattc ccttttttgc ggcattttgc cttcctgttt ttgctcaccc agaaacgctg     4200

gtgaaagtaa aagatgctga agatcagttg ggtgcacgag tgggttacat cgaactggat     4260

ctcaacagcg gtaagatcct tgagagtttt cgccccgaag aacgttttcc aatgatgagc     4320

acttttaaag ttctgctatg tggcgcggta ttatcccgta ttgacgccgg gcaagagcaa     4380

ctcggtcgcc gcatacacta ttctcagaat gacttggttg agtactcacc agtcacagaa     4440

aagcatctta cggatggcat gacagtaaga gaattatgca gtgctgccat aaccatgagt     4500

gataacactg cggccaactt acttctgaca acgatcggag gaccgaagga gctaaccgct     4560

tttttgcaca acatggggga tcatgtaact cgccttgatc gttgggaacc ggagctgaat     4620

gaagccatac caaacgacga gcgtgacacc acgatgcctg tagcaatggc aacaacgttg     4680

cgcaaactat taactggcga actacttact ctagcttccc ggcaacaatt aatagactgg     4740

atggaggcgg ataaagttgc aggaccactt ctgcgctcgg cccttccggc tggctggttt     4800

attgctgata aatctggagc cggtgagcgt gggtctcgcg gtatcattgc agcactgggg     4860

ccagatggta agccctcccg tatcgtagtt atctacacga cggggagtca ggcaactatg     4920

gatgaacgaa atagacagat cgctgagata ggtgcctcac tgattaagca ttggtaactg     4980

tcagaccaag tttactcata tatactttag attgatttaa aacttcattt ttaatttaaa     5040

aggatctagg tgaagatcct ttttgataat ctcatgacca aaatccctta acgtgagttt     5100

tcgttccact gagcgtcaga ccccgtagaa aagatcaaag gatcttcttg agatcctttt     5160

tttctgcgcg taatctgctg cttgcaaaca aaaaaaccac cgctaccagc ggtggtttgt     5220

ttgccggatc aagagctacc aactcttttt ccgaaggtaa ctggcttcag cagagcgcag     5280

ataccaaata ctgtccttct agtgtagccg tagttaggcc accacttcaa gaactctgta     5340

gcaccgcgta catacctcgc tctgctaatc ctgttaccag tggctgctgc cagtggcgat     5400

aagtcgtgtc ttaccgggtt ggactcaaga cgatagttac cggataaggc gcagcggtcg     5460

ggctgaacgg ggggttcgtg cacacagccc agcttggagc gaacgaccta caccgaactg     5520

agatacctac agcgtgagct atgagaaagc gccacgcttc ccgaagggag aaaggcggac     5580

aggtatccgg taagcggcag ggtcggaaca ggagagcgca cgagggagct tccaggggga     5640

aacgcctggt atctttatag tcctgtcggg tttcgccacc tctgacttga gcgtcgattt     5700

ttgtgatgct cgtcaggggg gcggagccta tggaaaaacg ccagcaacgc ggccttttta     5760

cggttcctgg ccttttgctg gccttttgct cacatgttct ttcctgcgtt atcccctgat     5820

tctgtggata accgtattac cgggtttgag tgagctgata ccgctcgccg cagccgaacg     5880

accgagcgca gcgagtcagt gagcgaccaa gcggaagagc                           5920


<210>  13
<211>  810
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<223>  MHCK7 sequence

<400>  13
gtttaaacaa gcttgcatgt ctaagctaga cccttcagat taaaaataac tgaggtaagg       60

gcctgggtag gggaggtggt gtgagacgct cctgtctctc ctctatctgc ccatcggccc      120

tttggggagg aggaatgtgc ccaaggacta aaaaaaggcc atggagccag aggggcgagg      180

gcaacagacc tttcatgggc aaaccttggg gccctgctgt ctagcatgcc ccactacggg      240

tctaggctgc ccatgtaagg aggcaaggcc tggggacacc cgagatgcct ggttataatt      300

aacccagaca tgtggctgcc cccccccccc caacacctgc tgcctctaaa aataaccctg      360

tccctggtgg atcccctgca tgcgaagatc ttcgaacaag gctgtggggg actgagggca      420

ggctgtaaca ggcttggggg ccagggctta tacgtgcctg ggactcccaa agtattactg      480

ttccatgttc ccggcgaagg gccagctgtc ccccgccagc tagactcagc acttagttta      540

ggaaccagtg agcaagtcag cccttggggc agcccataca aggccatggg gctgggcaag      600

ctgcacgcct gggtccgggg tgggcacggt gcccgggcaa cgagctgaaa gctcatctgc      660

tctcaggggc ccctccctgg ggacagcccc tcctggctag tcacaccctg taggctcctc      720

tatataaccc aggggcacag gggctgccct cattctacca ccacctccac agcacagaca      780

gacactcagg agccagccag cggcgcgccc                                       810


