                         SEQUENCE LISTING

<110>  BAYLOR COLLEGE OF MEDICINE
 
<120>  ASPROSIN, A FAST-INDUCED GLUCOGENIC PROTEIN HORMONE

<130>  BAYM.P0189WO

<150>  62322043
<151>  2016-04-13

<150>  62373565
<151>  2016-08-11

<160>  24    

<170>  PatentIn version 3.5

<210>  1
<211>  140
<212>  PRT
<213>  Homo sapiens

<400>  1

Ser Thr Asn Glu Thr Asp Ala Ser Asn Ile Glu Asp Gln Ser Glu Thr 
1               5                   10                  15      


Glu Ala Asn Val Ser Leu Ala Ser Trp Asp Val Glu Lys Thr Ala Ile 
            20                  25                  30          


Phe Ala Phe Asn Ile Ser His Val Ser Asn Lys Val Arg Ile Leu Glu 
        35                  40                  45              


Leu Leu Pro Ala Leu Thr Thr Leu Thr Asn His Asn Arg Tyr Leu Ile 
    50                  55                  60                  


Glu Ser Gly Asn Glu Asp Gly Phe Phe Lys Ile Asn Gln Lys Glu Gly 
65                  70                  75                  80  


Ile Ser Tyr Leu His Phe Thr Lys Lys Lys Pro Val Ala Gly Thr Tyr 
                85                  90                  95      


Ser Leu Gln Ile Ser Ser Thr Pro Leu Tyr Lys Lys Lys Glu Leu Asn 
            100                 105                 110         


Gln Leu Glu Asp Lys Tyr Asp Lys Asp Tyr Leu Ser Gly Glu Leu Gly 
        115                 120                 125             


Asp Asn Leu Lys Met Lys Ile Gln Val Leu Leu His 
    130                 135                 140 


<210>  2
<211>  147
<212>  PRT
<213>  Homo sapiens

<400>  2

Met His His His His His His Ser Thr Asn Glu Thr Asp Ala Ser Asn 
1               5                   10                  15      


Ile Glu Asp Gln Ser Glu Thr Glu Ala Asn Val Ser Leu Ala Ser Trp 
            20                  25                  30          


Asp Val Glu Lys Thr Ala Ile Phe Ala Phe Asn Ile Ser His Val Ser 
        35                  40                  45              


Asn Lys Val Arg Ile Leu Glu Leu Leu Pro Ala Leu Thr Thr Leu Thr 
    50                  55                  60                  


Asn His Asn Arg Tyr Leu Ile Glu Ser Gly Asn Glu Asp Gly Phe Phe 
65                  70                  75                  80  


Lys Ile Asn Gln Lys Glu Gly Ile Ser Tyr Leu His Phe Thr Lys Lys 
                85                  90                  95      


Lys Pro Val Ala Gly Thr Tyr Ser Leu Gln Ile Ser Ser Thr Pro Leu 
            100                 105                 110         


Tyr Lys Lys Lys Glu Leu Asn Gln Leu Glu Asp Lys Tyr Asp Lys Asp 
        115                 120                 125             


Tyr Leu Ser Gly Glu Leu Gly Asp Asn Leu Lys Met Lys Ile Gln Val 
    130                 135                 140                 


Leu Leu His 
145         


<210>  3
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  3

Glu Thr Glu Ala Asn Val Ser Leu Ala Ser Trp Asp Val Glu Lys Thr 
1               5                   10                  15      


Ala Ile Phe Ala Phe Asn Ile Ser His 
            20                  25  


<210>  4
<211>  28
<212>  PRT
<213>  Homo sapiens

<400>  4

Lys Lys Lys Glu Leu Asn Gln Leu Glu Asp Lys Tyr Asp Lys Asp Tyr 
1               5                   10                  15      


Leu Ser Gly Glu Leu Gly Asp Asn Leu Lys Met Lys 
            20                  25              


<210>  5
<211>  28
<212>  PRT
<213>  Mus musculus

<400>  5

Lys Lys Lys Glu Leu Asn Gln Leu Glu Asp Lys Tyr Asp Lys Asp Tyr 
1               5                   10                  15      


Leu Ser Gly Glu Leu Gly Asp Asn Leu Lys Met Lys 
            20                  25              


<210>  6
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  6

Arg Gly Arg Lys Arg Arg 
1               5       


<210>  7
<211>  171
<212>  PRT
<213>  Homo sapiens

<400>  7

Val Ser Gly Glu Met Asp Asp Asn Ser Leu Ser Pro Glu Ala Cys Tyr 
1               5                   10                  15      


Glu Cys Lys Ile Asn Gly Tyr Pro Lys Arg Gly Arg Lys Arg Arg Ser 
            20                  25                  30          


Thr Asn Glu Thr Asp Ala Ser Asn Ile Glu Asp Gln Ser Glu Thr Glu 
        35                  40                  45              


Ala Asn Val Ser Leu Ala Ser Trp Asp Val Glu Lys Thr Ala Ile Phe 
    50                  55                  60                  


Ala Phe Asn Ile Ser His Val Ser Asn Lys Val Arg Ile Leu Glu Leu 
65                  70                  75                  80  


Leu Pro Ala Leu Thr Thr Leu Thr Asn His Asn Arg Tyr Leu Ile Glu 
                85                  90                  95      


Ser Gly Asn Glu Asp Gly Phe Phe Lys Ile Asn Gln Lys Glu Gly Ile 
            100                 105                 110         


Ser Tyr Leu His Phe Thr Lys Lys Lys Pro Val Ala Gly Thr Tyr Ser 
        115                 120                 125             


Leu Gln Ile Ser Ser Thr Pro Leu Tyr Lys Lys Lys Glu Leu Asn Gln 
    130                 135                 140                 


Leu Glu Asp Lys Tyr Asp Lys Asp Tyr Leu Ser Gly Glu Leu Gly Asp 
145                 150                 155                 160 


Asn Leu Lys Met Lys Ile Gln Val Leu Leu His 
                165                 170     


<210>  8
<211>  36
<212>  PRT
<213>  Homo sapiens

<400>  8

Val Ser Gly Glu Met Asp Asp Asn Ser Leu Ser Pro Glu Ala Cys Tyr 
1               5                   10                  15      


Glu Cys Lys Ile Asn Gly Tyr Pro Lys Arg Gly Arg Lys Arg Arg Ser 
            20                  25                  30          


Thr Asn Glu Thr 
        35      


<210>  9
<211>  51
<212>  PRT
<213>  Homo sapiens

<400>  9

Val Ser Gly Glu Met Asp Asp Asn Ser Leu Ser Pro Glu Ala Cys Tyr 
1               5                   10                  15      


Glu Cys Lys Ile Asn Gly Tyr Pro Lys Arg Gly Arg Lys Arg Arg Ser 
            20                  25                  30          


Thr Asn Glu Thr Asp Ala Ser Asn Ile Glu Leu Gly Gln Lys Arg Gln 
        35                  40                  45              


Lys Pro Met 
    50      


<210>  10
<211>  35
<212>  PRT
<213>  Homo sapiens

<400>  10

Val Ser Gly Glu Met Asp Asp Asn Ser Leu Ser Pro Glu Ala Cys Tyr 
1               5                   10                  15      


Glu Cys Asp Gln Trp Leu Pro Gln Thr Gly Gln Glu Thr Glu Lys His 
            20                  25                  30          


Lys Arg Asn 
        35  


<210>  11
<211>  29
<212>  PRT
<213>  Homo sapiens

<400>  11

Val Ser Gly Glu Met Asp Asp Asn Ser Leu Ser Pro Glu Ala Cys Tyr 
1               5                   10                  15      


Glu Cys Thr Gly Gln Glu Thr Glu Lys His Lys Arg Asn 
            20                  25                  


<210>  12
<211>  51
<212>  PRT
<213>  Homo sapiens

<400>  12

Val Ser Gly Glu Met Asp Asp Asn Ser Leu Ser Pro Glu Ala Cys Tyr 
1               5                   10                  15      


Glu Cys Lys Ile Asn Gly Tyr Pro Lys Arg Gly Arg Lys Arg Arg Ser 
            20                  25                  30          


Thr Asn Glu Thr Asp Ala Ser Asn Ile Glu Leu Gly Gln Lys Arg Gln 
        35                  40                  45              


Lys Pro Met 
    50      


<210>  13
<211>  33
<212>  PRT
<213>  Homo sapiens

<400>  13

Val Ser Gly Glu Met Asp Asp Asn Ser Leu Ser Pro Glu Ala Cys Tyr 
1               5                   10                  15      


Glu Cys Lys Ile Asn Gly Tyr Pro Lys Glu Thr Glu Lys His Lys Arg 
            20                  25                  30          


Asn 
    


<210>  14
<211>  51
<212>  PRT
<213>  Homo sapiens

<400>  14

Val Ser Gly Glu Met Asp Asp Asn Ser Leu Ser Pro Glu Ala Cys Tyr 
1               5                   10                  15      


Glu Cys Lys Ile Asn Gly Tyr Pro Lys Arg Gly Arg Lys Arg Arg Ser 
            20                  25                  30          


Thr Asn Glu Thr Asp Ala Ser Asn Ile Glu Leu Gly Gln Lys Arg Gln 
        35                  40                  45              


Lys Pro Met 
    50      


<210>  15
<211>  231
<212>  PRT
<213>  Homo sapiens

<400>  15

Gln Phe Ser Gly Gly Cys Gln Asp Ile Asn Glu Cys Gly Ser Ala Gln 
1               5                   10                  15      


Ala Pro Cys Ser Tyr Gly Cys Ser Asn Thr Glu Gly Gly Tyr Leu Cys 
            20                  25                  30          


Gly Cys Pro Pro Gly Tyr Phe Arg Ile Gly Gln Gly His Cys Val Ser 
        35                  40                  45              


Gly Met Gly Met Gly Arg Gly Asn Pro Glu Pro Pro Val Ser Gly Glu 
    50                  55                  60                  


Met Asp Asp Asn Ser Leu Ser Pro Glu Ala Cys Tyr Glu Cys Lys Ile 
65                  70                  75                  80  


Asn Gly Tyr Pro Lys Arg Gly Arg Lys Arg Arg Ser Thr Asn Glu Thr 
                85                  90                  95      


Asp Ala Ser Asn Ile Glu Asp Gln Ser Glu Thr Glu Ala Asn Val Ser 
            100                 105                 110         


Leu Ala Ser Trp Asp Val Glu Lys Thr Ala Ile Phe Ala Phe Asn Ile 
        115                 120                 125             


Ser His Val Ser Asn Lys Val Arg Ile Leu Glu Leu Leu Pro Ala Leu 
    130                 135                 140                 


Thr Thr Leu Thr Asn His Asn Arg Tyr Leu Ile Glu Ser Gly Asn Glu 
145                 150                 155                 160 


Asp Gly Phe Phe Lys Ile Asn Gln Lys Glu Gly Ile Ser Tyr Leu His 
                165                 170                 175     


Phe Thr Lys Lys Lys Pro Val Ala Gly Thr Tyr Ser Leu Gln Ile Ser 
            180                 185                 190         


Ser Thr Pro Leu Tyr Lys Lys Lys Glu Leu Asn Gln Leu Glu Asp Lys 
        195                 200                 205             


Tyr Asp Lys Asp Tyr Leu Ser Gly Glu Leu Gly Asp Asn Leu Lys Met 
    210                 215                 220                 


Lys Ile Gln Val Leu Leu His 
225                 230     


<210>  16
<211>  96
<212>  PRT
<213>  Homo sapiens

<400>  16

Gln Phe Ser Gly Gly Cys Gln Asp Ile Asn Glu Cys Gly Ser Ala Gln 
1               5                   10                  15      


Ala Pro Cys Ser Tyr Gly Cys Ser Asn Thr Glu Gly Gly Tyr Leu Cys 
            20                  25                  30          


Gly Cys Pro Pro Gly Tyr Phe Arg Ile Gly Gln Gly His Cys Val Ser 
        35                  40                  45              


Gly Met Gly Met Gly Arg Gly Asn Pro Glu Pro Pro Val Ser Gly Glu 
    50                  55                  60                  


Met Asp Asp Asn Ser Leu Ser Pro Glu Ala Cys Tyr Glu Cys Lys Ile 
65                  70                  75                  80  


Asn Gly Tyr Pro Lys Arg Gly Arg Lys Arg Arg Ser Thr Asn Glu Asn 
                85                  90                  95      


<210>  17
<211>  51
<212>  PRT
<213>  Homo sapiens

<400>  17

Gln Phe Ser Gly Gly Cys Gln Asp Ile Asn Glu Cys Gly Ser Ala Gln 
1               5                   10                  15      


Ala Pro Cys Ser Tyr Gly Cys Ser Asn Thr Glu Gly Gly Tyr Leu Cys 
            20                  25                  30          


Gly Cys Pro Pro Gly Tyr Phe Arg Ile Gly Gln Ile Ser Leu Arg Gln 
        35                  40                  45              


Lys Pro Met 
    50      


<210>  18
<211>  95
<212>  PRT
<213>  Homo sapiens

<400>  18

Gln Phe Ser Gly Gly Cys Gln Asp Ile Asn Glu Cys Gly Ser Ala Gln 
1               5                   10                  15      


Ala Pro Cys Ser Tyr Gly Cys Ser Asn Thr Glu Gly Gly Tyr Leu Cys 
            20                  25                  30          


Gly Cys Pro Pro Gly Tyr Phe Arg Ile Gly Gln Gly His Cys Val Ser 
        35                  40                  45              


Gly Met Gly Met Gly Arg Gly Asn Pro Glu Pro Pro Val Ser Gly Glu 
    50                  55                  60                  


Met Asp Asp Asn Ser Leu Ser Pro Glu Ala Cys Tyr Glu Cys Asp Gln 
65                  70                  75                  80  


Trp Leu Pro Gln Thr Gly Gln Glu Thr Glu Lys His Lys Arg Asn 
                85                  90                  95  


<210>  19
<211>  89
<212>  PRT
<213>  Homo sapiens

<400>  19

Gln Phe Ser Gly Gly Cys Gln Asp Ile Asn Glu Cys Gly Ser Ala Gln 
1               5                   10                  15      


Ala Pro Cys Ser Tyr Gly Cys Ser Asn Thr Glu Gly Gly Tyr Leu Cys 
            20                  25                  30          


Gly Cys Pro Pro Gly Tyr Phe Arg Ile Gly Gln Gly His Cys Val Ser 
        35                  40                  45              


Gly Met Gly Met Gly Arg Gly Asn Pro Glu Pro Pro Val Ser Gly Glu 
    50                  55                  60                  


Met Asp Asp Asn Ser Leu Ser Pro Glu Ala Cys Tyr Glu Cys Thr Gly 
65                  70                  75                  80  


Gln Glu Thr Glu Lys His Lys Arg Asn 
                85                  


<210>  20
<211>  51
<212>  PRT
<213>  Homo sapiens

<400>  20

Gln Phe Ser Gly Gly Cys Gln Asp Ile Asn Glu Cys Gly Ser Ala Gln 
1               5                   10                  15      


Ala Pro Cys Ser Tyr Gly Cys Ser Asn Thr Glu Gly Gly Tyr Leu Cys 
            20                  25                  30          


Gly Cys Pro Pro Gly Tyr Phe Arg Ile Gly Gln Ile Ser Leu Arg Gln 
        35                  40                  45              


Lys Pro Met 
    50      


<210>  21
<211>  93
<212>  PRT
<213>  Homo sapiens

<400>  21

Gln Phe Ser Gly Gly Cys Gln Asp Ile Asn Glu Cys Gly Ser Ala Gln 
1               5                   10                  15      


Ala Pro Cys Ser Tyr Gly Cys Ser Asn Thr Glu Gly Gly Tyr Leu Cys 
            20                  25                  30          


Gly Cys Pro Pro Gly Tyr Phe Arg Ile Gly Gln Gly His Cys Val Ser 
        35                  40                  45              


Gly Met Gly Met Gly Arg Gly Asn Pro Glu Pro Pro Val Ser Gly Glu 
    50                  55                  60                  


Met Asp Asp Asn Ser Leu Ser Pro Glu Ala Cys Tyr Glu Cys Lys Ile 
65                  70                  75                  80  


Asn Gly Tyr Pro Lys Glu Thr Glu Lys His Lys Arg Asn 
                85                  90              


<210>  22
<211>  51
<212>  PRT
<213>  Homo sapiens

<400>  22

Gln Phe Ser Gly Gly Cys Gln Asp Ile Asn Glu Cys Gly Ser Ala Gln 
1               5                   10                  15      


Ala Pro Cys Ser Tyr Gly Cys Ser Asn Thr Glu Gly Gly Tyr Leu Cys 
            20                  25                  30          


Gly Cys Pro Pro Gly Tyr Phe Arg Ile Gly Gln Ile Ser Leu Arg Gln 
        35                  40                  45              


Lys Pro Met 
    50      


<210>  23
<211>  140
<212>  PRT
<213>  Homo sapiens

<400>  23

Ser Thr Asn Glu Thr Asp Ala Ser Asn Ile Glu Asp Gln Ser Glu Thr 
1               5                   10                  15      


Glu Ala Asn Val Ser Leu Ala Ser Trp Asp Val Glu Lys Thr Ala Ile 
            20                  25                  30          


Phe Ala Phe Asn Ile Ser His Val Ser Asn Lys Val Arg Ile Leu Glu 
        35                  40                  45              


Leu Leu Pro Ala Leu Thr Thr Leu Thr Asn His Asn Arg Tyr Leu Ile 
    50                  55                  60                  


Glu Ser Gly Asn Glu Asp Gly Phe Phe Lys Ile Asn Gln Lys Glu Gly 
65                  70                  75                  80  


Ile Ser Tyr Leu His Phe Thr Lys Lys Lys Pro Val Ala Gly Thr Tyr 
                85                  90                  95      


Ser Leu Gln Ile Ser Ser Thr Pro Leu Tyr Lys Lys Lys Glu Leu Asn 
            100                 105                 110         


Gln Leu Glu Asp Lys Tyr Asp Lys Asp Tyr Leu Ser Gly Glu Leu Gly 
        115                 120                 125             


Asp Asn Leu Lys Met Lys Ile Gln Val Leu Leu His 
    130                 135                 140 


<210>  24
<211>  146
<212>  PRT
<213>  Homo sapiens

<400>  24

His His His His His His Ser Thr Asn Glu Thr Asp Ala Ser Asn Ile 
1               5                   10                  15      


Glu Asp Gln Ser Glu Thr Glu Ala Asn Val Ser Leu Ala Ser Trp Asp 
            20                  25                  30          


Val Glu Lys Thr Ala Ile Phe Ala Phe Asn Ile Ser His Val Ser Asn 
        35                  40                  45              


Lys Val Arg Ile Leu Glu Leu Leu Pro Ala Leu Thr Thr Leu Thr Asn 
    50                  55                  60                  


His Asn Arg Tyr Leu Ile Glu Ser Gly Asn Glu Asp Gly Phe Phe Lys 
65                  70                  75                  80  


Ile Asn Gln Lys Glu Gly Ile Ser Tyr Leu His Phe Thr Lys Lys Lys 
                85                  90                  95      


Pro Val Ala Gly Thr Tyr Ser Leu Gln Ile Ser Ser Thr Pro Leu Tyr 
            100                 105                 110         


Lys Lys Lys Glu Leu Asn Gln Leu Glu Asp Lys Tyr Asp Lys Asp Tyr 
        115                 120                 125             


Leu Ser Gly Glu Leu Gly Asp Asn Leu Lys Met Lys Ile Gln Val Leu 
    130                 135                 140                 


Leu His 
145     


