                         SEQUENCE LISTING

<110>  University of Vermont and State Agricultural College
       Botten, Jason
       Klaus, Joseph
       Mason, Anne
 
<120>  METHODS AND COMPOSITIONS FOR REDUCING VIRUS INFECTIVITY

<130>  UVM70123WO

<150>  US 62/321928
<151>  2016-04-13

<160>  16    

<170>  PatentIn version 3.5

<210>  1
<211>  146
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Thr Met Arg Ser Leu Leu Arg Thr Pro Phe Leu Cys Gly Leu Leu 
1               5                   10                  15      


Trp Ala Phe Cys Ala Pro Gly Ala Arg Ala Glu Glu Pro Ala Ala Ser 
            20                  25                  30          


Phe Ser Gln Pro Gly Ser Met Gly Leu Asp Lys Asn Thr Val His Asp 
        35                  40                  45              


Gln Glu His Ile Met Glu His Leu Glu Gly Val Ile Asn Lys Pro Glu 
    50                  55                  60                  


Ala Glu Met Ser Pro Gln Glu Leu Gln Leu His Tyr Phe Lys Met His 
65                  70                  75                  80  


Asp Tyr Asp Gly Asn Asn Leu Leu Asp Gly Leu Glu Leu Ser Thr Ala 
                85                  90                  95      


Ile Thr His Val His Lys Glu Glu Gly Ser Glu Gln Ala Pro Leu Met 
            100                 105                 110         


Ser Glu Asp Glu Leu Ile Asn Ile Ile Asp Gly Val Leu Arg Asp Asp 
        115                 120                 125             


Asp Lys Asn Asn Asp Gly Tyr Ile Asp Tyr Ala Glu Phe Ala Lys Ser 
    130                 135                 140                 


Leu Gln 
145     


<210>  2
<211>  4115
<212>  DNA
<213>  Homo sapiens

<400>  2
gaagccgagg aagagcgttt tggggacggg ggctggtgag gctcacgttg gagggcttcg       60

cgtctgcttc ggagaccgta aggatattga tgaccatgag atccctgctc agaaccccct      120

tcctgtgtgg cctgctctgg gccttttgtg ccccaggcgc cagggctgag gagcctgcag      180

ccagcttctc ccaacccggc agcatgggcc tggataagaa cacagtgcac gaccaagagc      240

atatcatgga gcatctagaa ggtgtcatca acaaaccaga ggcggagatg tcgccacaag      300

aattgcagct ccattacttc aaaatgcatg attatgatgg caataatttg cttgatggct      360

tagaactctc cacagccatc actcatgtcc ataaggagga agggagtgaa caggcaccac      420

taatgagtga agatgaactg attaacataa tagatggtgt tttgagagat gatgacaaga      480

acaatgatgg atacattgac tatgctgaat ttgcaaaatc actgcagtag atgttatttg      540

gccatctcct ggttatatac aaatgtgacc cgtgataatg tgattgaaca ctttagtaat      600

gcaaaataac tcatttccaa ctactgctgc agcattttgg taaaaacctg tagcgattcg      660

ttacactggg gtgagaagag ataagagaaa tgaaagagaa gagaaatggg acatctaata      720

gtccctaagt gctattaaat accttattgg acaagggctt gcttcaagca tctgtattag      780

tctgtattaa tgctgctgat aaagacgtac ccgagactgg gaagaaaaag aggtttactt      840

ggacttacag ttccacatgg ctggggaggc ctcagaatca tggcgggagg tgaaaggcac      900

ttcttacatg gcagcaagag aaaatgagga agaagcaaaa gtggaaaccc ctgataagcc      960

atcagatctt gtgaaactta ttcactatca caagaatagc atgggaaaga ctggccccca     1020

tgattcaatt acctcccctt gggtctctcc cacaacacgt gggaattctg gtagatacaa     1080

tttcaagttg agatttgggt ggggacatag ccaaaccata tcattctacc cctggcccct     1140

ccaaatctca tgtcctcact attcaaaacc aatcatgcct tcctaacagt cccccaaagt     1200

cttaactctt ttcagcatta acgcaaaaat ccacagtcca aagtctcatc tgagacaagg     1260

caagtccctt ccacctatga gcctgtaaaa tcaaaagcaa gctagttact tcctagatac     1320

caacaggggt acaggtattg attaaagacg gctgttccaa atgggagaaa ttggccaaaa     1380

taaaggggtt acagggccca tgcaagtccg aaatccagca gggctgtcaa attttaaagt     1440

tccagaataa tctcctttga ctccaggtct cacatccagg tcatactgat gcaagaagtg     1500

ggttcccatg gtcttgggca gctctgcccc tgtggctttg tagggtacag cctccctcct     1560

ggctgctttc acggctgttg ttcagtgcct gcggcttttc caggtgcacg gtgcaagctg     1620

ttggtggatc taccattctg gggtctggag gacggtggcc ctcttctcac agctccacta     1680

ggcagtgccc cagtagggac tctgtgtggg ggctcccaca ccacatttcc cttctgcact     1740

gccctagcag aggttctctc ccctgccgct gagagggcct ctcccctgca gcaaacgttt     1800

gcctgggcat tgaggcattt ccatacatct tctgaaaact aggcggaggt ttccaaatct     1860

caattcttga cttctgtgca cctgcaggct taacagcaca tagaagctgc caaggcttgg     1920

ggcttccact ctgaagccac agcccgagct gtatgttggc ccctttcagc catggctgga     1980

gtggctggga cacaagacac caagtcccta ggctgcacac acatgtcagg ggctgccctg     2040

acatggcctg gagacatttt ccccatggtg ttggggatta acattaggct ccttgctact     2100

tatgcaaatt tctgcagctg gcttgaattt ctccccagaa aatgggtttt tcttttctat     2160

tgcatagtca ggctgcaaat ttccaaactt ttatgctttg cttcccttat ttataaggga     2220

atgcctttaa aagcacccaa gtcacctgtt gaacactttg ctgcttagaa atttcttccg     2280

ctagttaacc taaatcatct ctctcaagtt caaagttcca caaatcccta tggaaggggc     2340

aaaatgctgc cagtctcttt gctaaaacat aacaagagtc acctttactc cagttcccaa     2400

caagttcctc atcttcatct gaggccacct cagcctggac tttgttgtcc atattgctat     2460

cagcatttgg ggcaaagcca ttcaacaagt ctgtaggaag ttccaaactt tcccacattt     2520

tcctgttttc ttctgagccc tccaaactgt tccagcctct gcctgttacc cagttccaaa     2580

gtcacttcca cattttgggt atttcttcag caggtcccaa tctactggta ccaatttact     2640

gtattagtcc gttttcacgc tgctgataaa gacatacccg agactgggaa gaaaaagtgg     2700

tttaattgga cttaaagttc cacatggctg gggaggcctc agaatcatgg tgggaggcaa     2760

aagacacttc ttacattgtg gcaagaaaaa atgaggaaga agcaaaagca gaaacccctg     2820

ataaactgat cagatctcat gagacttatt cactgtcacg agaatagcac gggaaagact     2880

ggcccccatg attcaattac ctccccctgg gtctgtccca caacacgtgg gaattctggg     2940

agatacaatt caagttgaga tttgtggggg gacacaacca aaccatatca gcatcctttc     3000

aagaatatta gataattgga gctgagtact caggaacttg actgtagtag aatactgcta     3060

gtttcttaat tttaattcac atcacctgaa aagtaaaaca acaggctttg ccaagtggat     3120

gcttttcagt aacagtgaag tggagtgaat accaaatgtt tgccctggtg gttcctatct     3180

cttcaggcaa acatggtcag tattctgtaa agttcccctg gcctaaatga ttacttgctc     3240

tgggcaagtg gatatttatt aggctatttc aaagccacag cataagaatg tcagcctagc     3300

cacagagtct gagattctga gttcagccta gccacagagt ctaagattct gtatcctctg     3360

acattttgga aatgatacac tactggctta agtgatgact ctttcagatt ttcagtattt     3420

tatacaacta ctgccacatc cttatacttt attgcttttc tgtcttcttc aacctgggag     3480

agaccctgaa tttgagtgtg ttctctaatc aatagtggtt tagctttctt ttctatttca     3540

ctcgtttcta gggtttttta tttgcagttt aggaactatt aggaatgtca ggactttatc     3600

agcaggggta aaactaccac ctggcctagc ctaagtagga agtgaaaaga taattcacca     3660

aacaatgatt aatcagatag aagttctagt caagagggat attgttgaag ttacctcttt     3720

tagcctagat acatggattc ttttcaaatc aggaaagatt agaaaaggaa cccaaaaaac     3780

cctttaacag tgtgaatctt tatagtattt gaaaatgaga agaagcagca gattgtaatt     3840

tggtttattg gatgtgatgg acgttctgta atagaaaacc tgaaacgatg attgaatggg     3900

aaaaagagac tacaaaattt gtcgtaggat gtatacagac ttattttctt tattacagta     3960

ttataagaaa acatatgtat ttgtaaaaat ggtttcctgt gtcaagtatt tgtgcagtca     4020

gagctgactt gtaaactatt cttgtaatag ctcattattt tgaaagattt atatatgatg     4080

aattctggat atatgaccaa taaaactgat gaagc                                4115


<210>  3
<211>  510
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Ala Gly Ser Arg Gln Arg Gly Leu Arg Ala Arg Val Arg Pro Leu 
1               5                   10                  15      


Phe Cys Ala Leu Leu Leu Ser Leu Gly Arg Phe Val Arg Gly Asp Gly 
            20                  25                  30          


Val Gly Gly Asp Pro Ala Val Ala Leu Pro His Arg Arg Phe Glu Tyr 
        35                  40                  45              


Lys Tyr Ser Phe Lys Gly Pro His Leu Val Gln Ser Asp Gly Thr Val 
    50                  55                  60                  


Pro Phe Trp Ala His Ala Gly Asn Ala Ile Pro Ser Ser Asp Gln Ile 
65                  70                  75                  80  


Arg Val Ala Pro Ser Leu Lys Ser Gln Arg Gly Ser Val Trp Thr Lys 
                85                  90                  95      


Thr Lys Ala Ala Phe Glu Asn Trp Glu Val Glu Val Thr Phe Arg Val 
            100                 105                 110         


Thr Gly Arg Gly Arg Ile Gly Ala Asp Gly Leu Ala Ile Trp Tyr Ala 
        115                 120                 125             


Glu Asn Gln Gly Leu Glu Gly Pro Val Phe Gly Ser Ala Asp Leu Trp 
    130                 135                 140                 


Asn Gly Val Gly Ile Phe Phe Asp Ser Phe Asp Asn Asp Gly Lys Lys 
145                 150                 155                 160 


Asn Asn Pro Ala Ile Val Ile Ile Gly Asn Asn Gly Gln Ile His Tyr 
                165                 170                 175     


Asp His Gln Asn Asp Gly Ala Ser Gln Ala Leu Ala Ser Cys Gln Arg 
            180                 185                 190         


Asp Phe Arg Asn Lys Pro Tyr Pro Val Arg Ala Lys Ile Thr Tyr Tyr 
        195                 200                 205             


Gln Asn Thr Leu Thr Val Met Ile Asn Asn Gly Phe Thr Pro Asp Lys 
    210                 215                 220                 


Asn Asp Tyr Glu Phe Cys Ala Lys Val Glu Asn Met Ile Ile Pro Ala 
225                 230                 235                 240 


Gln Gly His Phe Gly Ile Ser Ala Ala Thr Gly Gly Leu Ala Asp Asp 
                245                 250                 255     


His Asp Val Leu Ser Phe Leu Thr Phe Gln Leu Thr Glu Pro Gly Lys 
            260                 265                 270         


Glu Pro Pro Thr Pro Asp Lys Glu Ile Ser Glu Lys Glu Lys Glu Lys 
        275                 280                 285             


Tyr Gln Glu Glu Phe Glu His Phe Gln Gln Glu Leu Asp Lys Lys Lys 
    290                 295                 300                 


Glu Glu Phe Gln Lys Gly His Pro Asp Leu Gln Gly Gln Pro Ala Glu 
305                 310                 315                 320 


Glu Ile Phe Glu Ser Val Gly Asp Arg Glu Leu Arg Gln Val Phe Glu 
                325                 330                 335     


Gly Gln Asn Arg Ile His Leu Glu Ile Lys Gln Leu Asn Arg Gln Leu 
            340                 345                 350         


Asp Met Ile Leu Asp Glu Gln Arg Arg Tyr Val Ser Ser Leu Thr Glu 
        355                 360                 365             


Glu Ile Ser Lys Arg Gly Ala Gly Met Pro Gly Gln His Gly Gln Ile 
    370                 375                 380                 


Thr Gln Gln Glu Leu Asp Thr Val Val Lys Thr Gln His Glu Ile Leu 
385                 390                 395                 400 


Arg Gln Val Asn Glu Met Lys Asn Ser Met Ser Glu Thr Val Arg Leu 
                405                 410                 415     


Val Ser Gly Met Gln His Pro Gly Ser Ala Gly Gly Val Tyr Glu Thr 
            420                 425                 430         


Thr Gln His Phe Ile Asp Ile Lys Glu His Leu His Ile Val Lys Arg 
        435                 440                 445             


Asp Ile Asp Asn Leu Val Gln Arg Asn Met Pro Ser Asn Glu Lys Pro 
    450                 455                 460                 


Lys Cys Pro Glu Leu Pro Pro Phe Pro Ser Cys Leu Ser Thr Val His 
465                 470                 475                 480 


Phe Ile Ile Phe Val Val Val Gln Thr Val Leu Phe Ile Gly Tyr Ile 
                485                 490                 495     


Met Tyr Arg Ser Gln Gln Glu Ala Ala Ala Lys Lys Phe Phe 
            500                 505                 510 


<210>  4
<211>  4848
<212>  DNA
<213>  Homo sapiens

<400>  4
ctcccgccct cctccgcgtt ccagaatcca agatggcggg atccaggcaa aggggtctcc       60

gggccagagt tcggccgctg ttctgcgcct tgctgctgtc actcggtcgc ttcgtccggg      120

gcgacggcgt gggaggagac cccgcggtcg cgttgccaca tcgccgtttc gagtacaaat      180

acagcttcaa ggggccgcac ctggtgcaga gcgacgggac cgtgcccttc tgggcccacg      240

cggggaatgc tattccaagt tcagatcaaa ttcgagtagc accatcttta aaaagccaaa      300

gaggctcagt gtggacaaag acaaaagcgg cctttgagaa ctgggaagtt gaggtgacat      360

ttcgagtgac tggaagaggt cgaattggag ctgatggcct agcaatttgg tatgcagaaa      420

atcaaggctt ggagggccct gtgtttggat cagctgatct gtggaatggt gttggaatat      480

tttttgattc ttttgacaat gatggaaaga aaaataatcc tgctatagta attataggca      540

acaatggaca aatccattat gaccatcaaa atgacggggc tagtcaagct ttggcaagtt      600

gccagaggga cttccgcaac aaaccctatc ctgtccgagc aaagattacc tattaccaga      660

acacactgac agtaatgatc aataatggct ttacaccaga taaaaatgat tatgaatttt      720

gtgccaaagt ggaaaatatg attatccctg cacaagggca ttttggaata tctgctgcaa      780

ctggaggtct tgcagatgac catgatgtcc tttcttttct gactttccag ttgactgaac      840

ctggaaaaga gccgcccaca ccagataaag aaatttcgga aaaggaaaaa gaaaagtatc      900

aggaggaatt tgagcacttt caacaagaat tggataaaaa aaaagaggaa ttccagaagg      960

gccaccccga cctccaaggg cagcctgcgg aggaaatatt tgagagtgta ggagatcgag     1020

agctaagaca agtctttgaa ggacagaatc gtattcatct tgaaatcaag cagctgaacc     1080

ggcagttaga tatgattctt gatgaacaga gaagatatgt ctcttcctta acagaggaaa     1140

tctctaaaag aggagcagga atgcctgggc agcatgggca gattactcaa caagaactgg     1200

atactgttgt gaaaactcag catgagattc tgagacaagt aaatgaaatg aaaaattcca     1260

tgagtgaaac cgtcagactg gtcagtggaa tgcagcaccc tggctctgct ggaggcgtct     1320

atgagacaac acagcacttc attgacatca aagagcacct gcacatagta aagagggaca     1380

tagataactt agtgcagcga aatatgccat caaatgaaaa gccgaaatgc ccagaactac     1440

caccatttcc atcatgtttg tctacggtcc acttcattat atttgttgtg gtgcaaactg     1500

tattattcat tggttatatc atgtataggt ctcagcaaga agcagctgcc aaaaaattct     1560

tttgactacc attttcctgt gtacttcatc tatttgtgta caaaatgatg tcgttttgag     1620

ggaatttaag tatttaaatt gcttcatagt ctaaattatt aattttctta ataaaataac     1680

tgtttaaaca ttgatttgca gttaagaata aaccttaaag caaagacaac cacattttaa     1740

tttgttcaca gtatgtaaat ctgtctaaat ttcagtgaat ttctggtcag tatgatgcag     1800

cctctgagca gaatattgac cagtaagagg gtaaataaag tgggggcaac ccctggatat     1860

gaatgttacc ccctaagtct ccaatattgc aggtttccct gtataacgta aacacacttg     1920

ccctcatgcc tcccagaata tgaggtctaa ttaagaagtc ccatcaggtt tattttgtaa     1980

ccaaagtctt ttttagaggt cagacttcct aatcaaaggc ctgggcctgc agtcctttca     2040

tcttaatgca acttcctttg aaatcaaaga atattttgtc tgagagcttt aaggatctgg     2100

taatagactt caaaatgtta agtgaaattt ttttttcctc tatttatcaa tgatatattt     2160

cacttttaaa ggaaatttta gaggaaaatt aatagctgct ttttgcctaa aaaaccttgt     2220

gggtggaaac attcctctga gaatggcttt tataggtatt ttgcctggta atgtattcat     2280

tcatgattgc ccatattctt gaatgtcttc attccaatgg ggtcaggtca atattatgaa     2340

aataattttt atatttatat ttgtaactta aggaatttat ttctcccttt actacagcat     2400

gtaaattcag ctcaaattgc atgatctgag gatttaaatt cacaaaacct gccactacat     2460

tctggtttac attagttact tcatgctggc tggggttagt gaccatttgc atactctttt     2520

aaatcaagga ggctgtagta gaagcagttt taagattctt gaaggcaaaa tttgaaaaac     2580

agtgaatact tctaattgtt tccttttagt gccagaacta aggacattgt gaagcacttg     2640

ttagtaaact taaccttgaa atgtcagact ggaaggagtt tttatagtct ttgtgcatac     2700

ttctaggtat tacagaaaca gtctgtaaat gacattttaa gatgcaaatt taattctgtt     2760

cacagctgat ttatactgat ttttgctgcc ttcaaaatac tcttttactt cttttagcta     2820

aaatggttgt ctttcatttg ccatagaatt ccaaacaata ctatcttata aaatagtact     2880

gttgaattat tccaagcctc cctaggtttg ctctcaaatg tcatttacag attgggctaa     2940

cgacctaaaa tctatatata aagactttct gaagaactct gtattatagc aataccaaac     3000

gagtgctgtg tgtgcaaaca gtctggcgtt gctttttatg ttgatattta tcctagaaca     3060

ctgaaagaga atatgccagt gataactcac tttacttcag tcatttcaac acagaaaatg     3120

cttctctagc atttttcttt tgtagtgtta acattttgaa attcatgttt cagaggcttc     3180

atcatcacag aatttactct tgctccatga aaaaaaatta aataccttca gaggaatatt     3240

taagttgtaa actatgaaac ttgagaaatc ctcttgagat aaaaggctgc caaatccagt     3300

attataaagt ccatggtcat atgtgcctgt gcattaaagg aataccagat ctatgcagta     3360

tacatttttc aggctgaaat tcaaggggaa tcattctgat tattcttact acaaatggag     3420

atggctatta tgaaacagca tgagcatgag ccttttatct tttatactta gtgatatact     3480

ttgcttgaaa atcactcagc aaagtagttc acatgatgtg tatcatattt gaagtgtggt     3540

ttttctcaaa atcattgact ttaaggagct catttctgaa caaaaaggtt tgctctgtgg     3600

aaaaatcaat cactgccagg attctttcat ttctgtacta ttttgtataa ttgaatttgt     3660

tcacttctct cacaccagca agtgttttac aggtgccttg gattaaaaca aaattgattt     3720

taaaattttt atgtaagtca ttgtgtctat gatgccactt ttaaaaggaa aatgcaattg     3780

cgtaatggct tatatcctta tttaatgtac ctatttgtgt tctaataatt gtttgaatgt     3840

tttattcagc ttaaaacttt accatgaagt cataaacagt aaacaatgtt ttgttatgta     3900

ttaaggggat atcagtgttt ctcaaagtat gatccatgga ccatctgggt catggcgcct     3960

ggtttcagac aacctgaatc aaatcttagg ggtggggctt tgggatgtca ttgttcaata     4020

ggcacctcag gagattctga gcacaccaat gtttgagaac cactaaaatg aggagtggga     4080

aaaaaaaaat aggtgttttg ttaatttaga gctgagctga gaagataata tatttttatt     4140

gtcaatgaca ttaacagata tgcactgatt cttttatacc tacaatttac ttaatgttcc     4200

ttttattaaa acgcgtggtt catgagcaac tacagactga atccagatta ttacctgttg     4260

ctttcagtat tttcgtgatg gcttttaatc ttatgaaatc atcttgagat cattcatggt     4320

caagccatga aaactcccat cttcaagcct gcctgctaaa gcttctttgc cttcctgatt     4380

gtgattatgg taacaattta tatcagacag ttgtactttt tgataactta gggaaaacag     4440

aaatgacttg aacaagggat tgcctgcctc actgcattgc agagatacaa tttttgtaaa     4500

gaacacaaat agcagttgtg aatattaagg tgtgattatc tttccctgtc catgtgctta     4560

ttgaaagaag atagtgaaca aatgattata ttgaggattt ttttaattta taagatctaa     4620

tgtgaaatcc acacttggaa ctttttagat ctgtctgttg cttgtttaat atatttcttt     4680

tatgacatta cttaaagttt aaaagggttt tctatccact gtcaatttca attggataac     4740

attttgtcaa gttttttttt tcctgattat ttgatgctag ctggaattca agaaatggca     4800

ttgaccttat tcaaataaag aaatatttta gtaaaaaaaa aaaaaaaa                  4848


<210>  5
<211>  143
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Thr Met Arg Ser Leu Leu Arg Thr Pro Phe Leu Cys Gly Leu Leu 
1               5                   10                  15      


Trp Ala Phe Cys Ala Pro Gly Ala Arg Ala Glu Glu Pro Ala Ala Ser 
            20                  25                  30          


Phe Ser Gln Pro Gly Ser Met Gly Leu Asp Lys Asn Thr Val His Asp 
        35                  40                  45              


Gln Glu His Ile Met Glu His Leu Glu Gly Val Ile Asn Lys Pro Glu 
    50                  55                  60                  


Ala Glu Met Ser Pro Gln Glu Leu Gln Leu His Tyr Phe Lys Met His 
65                  70                  75                  80  


Asp Tyr Asp Gly Asn Asn Leu Leu Asp Gly Leu Glu Leu Ser Thr Ala 
                85                  90                  95      


Ile Thr His Val His Lys Glu Glu Gly Ser Glu Gln Ala Pro Leu Met 
            100                 105                 110         


Ser Glu Asp Glu Leu Ile Asn Ile Ile Asp Gly Val Leu Arg Asp Asp 
        115                 120                 125             


Asp Lys Asn Asn Asp Gly Tyr Ile Asp Tyr Ala Glu Phe Ala Lys 
    130                 135                 140             


<210>  6
<211>  118
<212>  PRT
<213>  Homo sapiens

<400>  6

Pro Ala Ala Ser Phe Ser Gln Pro Gly Ser Met Gly Leu Asp Lys Asn 
1               5                   10                  15      


Thr Val His Asp Gln Glu His Ile Met Glu His Leu Glu Gly Val Ile 
            20                  25                  30          


Asn Lys Pro Glu Ala Glu Met Ser Pro Gln Glu Leu Gln Leu His Tyr 
        35                  40                  45              


Phe Lys Met His Asp Tyr Asp Gly Asn Asn Leu Leu Asp Gly Leu Glu 
    50                  55                  60                  


Leu Ser Thr Ala Ile Thr His Val His Lys Glu Glu Gly Ser Glu Gln 
65                  70                  75                  80  


Ala Pro Leu Met Ser Glu Asp Glu Leu Ile Asn Ile Ile Asp Gly Val 
                85                  90                  95      


Leu Arg Asp Asp Asp Lys Asn Asn Asp Gly Tyr Ile Asp Tyr Ala Glu 
            100                 105                 110         


Phe Ala Lys Ser Leu Gln 
        115             


<210>  7
<211>  69
<212>  PRT
<213>  Homo sapiens

<400>  7

Lys Met His Asp Tyr Asp Gly Asn Asn Leu Leu Asp Gly Leu Glu Leu 
1               5                   10                  15      


Ser Thr Ala Ile Thr His Val His Lys Glu Glu Gly Ser Glu Gln Ala 
            20                  25                  30          


Pro Leu Met Ser Glu Asp Glu Leu Ile Asn Ile Ile Asp Gly Val Leu 
        35                  40                  45              


Arg Asp Asp Asp Lys Asn Asn Asp Gly Tyr Ile Asp Tyr Ala Glu Phe 
    50                  55                  60                  


Ala Lys Ser Leu Gln 
65                  


<210>  8
<211>  51
<212>  PRT
<213>  Homo sapiens

<400>  8

Asn Asn Leu Leu Asp Gly Leu Glu Leu Ser Thr Ala Ile Thr His Val 
1               5                   10                  15      


His Lys Glu Glu Gly Ser Glu Gln Ala Pro Leu Met Ser Glu Asp Glu 
            20                  25                  30          


Leu Ile Asn Ile Ile Asp Gly Val Leu Arg Asp Asp Asp Lys Asn Asn 
        35                  40                  45              


Asp Gly Tyr 
    50      


<210>  9
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  9

Gln Gln Glu Ala Ala Ala Lys Lys Phe Phe 
1               5                   10  


<210>  10
<211>  33
<212>  PRT
<213>  Homo sapiens

<400>  10

Thr Val His Phe Ile Ile Phe Val Val Val Gln Thr Val Leu Phe Ile 
1               5                   10                  15      


Gly Tyr Ile Met Tyr Arg Ser Gln Gln Glu Ala Ala Ala Lys Lys Phe 
            20                  25                  30          


Phe 
    


<210>  11
<211>  477
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Ala Gly Ser Arg Gln Arg Gly Leu Arg Ala Arg Val Arg Pro Leu 
1               5                   10                  15      


Phe Cys Ala Leu Leu Leu Ser Leu Gly Arg Phe Val Arg Gly Asp Gly 
            20                  25                  30          


Val Gly Gly Asp Pro Ala Val Ala Leu Pro His Arg Arg Phe Glu Tyr 
        35                  40                  45              


Lys Tyr Ser Phe Lys Gly Pro His Leu Val Gln Ser Asp Gly Thr Val 
    50                  55                  60                  


Pro Phe Trp Ala His Ala Gly Asn Ala Ile Pro Ser Ser Asp Gln Ile 
65                  70                  75                  80  


Arg Val Ala Pro Ser Leu Lys Ser Gln Arg Gly Ser Val Trp Thr Lys 
                85                  90                  95      


Thr Lys Ala Ala Phe Glu Asn Trp Glu Val Glu Val Thr Phe Arg Val 
            100                 105                 110         


Thr Gly Arg Gly Arg Ile Gly Ala Asp Gly Leu Ala Ile Trp Tyr Ala 
        115                 120                 125             


Glu Asn Gln Gly Leu Glu Gly Pro Val Phe Gly Ser Ala Asp Leu Trp 
    130                 135                 140                 


Asn Gly Val Gly Ile Phe Phe Asp Ser Phe Asp Asn Asp Gly Lys Lys 
145                 150                 155                 160 


Asn Asn Pro Ala Ile Val Ile Ile Gly Asn Asn Gly Gln Ile His Tyr 
                165                 170                 175     


Asp His Gln Asn Asp Gly Ala Ser Gln Ala Leu Ala Ser Cys Gln Arg 
            180                 185                 190         


Asp Phe Arg Asn Lys Pro Tyr Pro Val Arg Ala Lys Ile Thr Tyr Tyr 
        195                 200                 205             


Gln Asn Thr Leu Thr Val Met Ile Asn Asn Gly Phe Thr Pro Asp Lys 
    210                 215                 220                 


Asn Asp Tyr Glu Phe Cys Ala Lys Val Glu Asn Met Ile Ile Pro Ala 
225                 230                 235                 240 


Gln Gly His Phe Gly Ile Ser Ala Ala Thr Gly Gly Leu Ala Asp Asp 
                245                 250                 255     


His Asp Val Leu Ser Phe Leu Thr Phe Gln Leu Thr Glu Pro Gly Lys 
            260                 265                 270         


Glu Pro Pro Thr Pro Asp Lys Glu Ile Ser Glu Lys Glu Lys Glu Lys 
        275                 280                 285             


Tyr Gln Glu Glu Phe Glu His Phe Gln Gln Glu Leu Asp Lys Lys Lys 
    290                 295                 300                 


Glu Glu Phe Gln Lys Gly His Pro Asp Leu Gln Gly Gln Pro Ala Glu 
305                 310                 315                 320 


Glu Ile Phe Glu Ser Val Gly Asp Arg Glu Leu Arg Gln Val Phe Glu 
                325                 330                 335     


Gly Gln Asn Arg Ile His Leu Glu Ile Lys Gln Leu Asn Arg Gln Leu 
            340                 345                 350         


Asp Met Ile Leu Asp Glu Gln Arg Arg Tyr Val Ser Ser Leu Thr Glu 
        355                 360                 365             


Glu Ile Ser Lys Arg Gly Ala Gly Met Pro Gly Gln His Gly Gln Ile 
    370                 375                 380                 


Thr Gln Gln Glu Leu Asp Thr Val Val Lys Thr Gln His Glu Ile Leu 
385                 390                 395                 400 


Arg Gln Val Asn Glu Met Lys Asn Ser Met Ser Glu Thr Val Arg Leu 
                405                 410                 415     


Val Ser Gly Met Gln His Pro Gly Ser Ala Gly Gly Val Tyr Glu Thr 
            420                 425                 430         


Thr Gln His Phe Ile Asp Ile Lys Glu His Leu His Ile Val Lys Arg 
        435                 440                 445             


Asp Ile Asp Asn Leu Val Gln Arg Asn Met Pro Ser Asn Glu Lys Pro 
    450                 455                 460                 


Lys Cys Pro Glu Leu Pro Pro Phe Pro Ser Cys Leu Ser 
465                 470                 475         


<210>  12
<211>  225
<212>  PRT
<213>  Homo sapiens

<400>  12

Arg Arg Phe Glu Tyr Lys Tyr Ser Phe Lys Gly Pro His Leu Val Gln 
1               5                   10                  15      


Ser Asp Gly Thr Val Pro Phe Trp Ala His Ala Gly Asn Ala Ile Pro 
            20                  25                  30          


Ser Ser Asp Gln Ile Arg Val Ala Pro Ser Leu Lys Ser Gln Arg Gly 
        35                  40                  45              


Ser Val Trp Thr Lys Thr Lys Ala Ala Phe Glu Asn Trp Glu Val Glu 
    50                  55                  60                  


Val Thr Phe Arg Val Thr Gly Arg Gly Arg Ile Gly Ala Asp Gly Leu 
65                  70                  75                  80  


Ala Ile Trp Tyr Ala Glu Asn Gln Gly Leu Glu Gly Pro Val Phe Gly 
                85                  90                  95      


Ser Ala Asp Leu Trp Asn Gly Val Gly Ile Phe Phe Asp Ser Phe Asp 
            100                 105                 110         


Asn Asp Gly Lys Lys Asn Asn Pro Ala Ile Val Ile Ile Gly Asn Asn 
        115                 120                 125             


Gly Gln Ile His Tyr Asp His Gln Asn Asp Gly Ala Ser Gln Ala Leu 
    130                 135                 140                 


Ala Ser Cys Gln Arg Asp Phe Arg Asn Lys Pro Tyr Pro Val Arg Ala 
145                 150                 155                 160 


Lys Ile Thr Tyr Tyr Gln Asn Thr Leu Thr Val Met Ile Asn Asn Gly 
                165                 170                 175     


Phe Thr Pro Asp Lys Asn Asp Tyr Glu Phe Cys Ala Lys Val Glu Asn 
            180                 185                 190         


Met Ile Ile Pro Ala Gln Gly His Phe Gly Ile Ser Ala Ala Thr Gly 
        195                 200                 205             


Gly Leu Ala Asp Asp His Asp Val Leu Ser Phe Leu Thr Phe Gln Leu 
    210                 215                 220                 


Thr 
225 


<210>  13
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  13

Glu Tyr Lys Tyr Ser Phe Lys Gly Pro His Leu Val Gln Ser 
1               5                   10                  


<210>  14
<211>  36
<212>  PRT
<213>  Homo sapiens

<400>  14

Arg Arg Phe Glu Tyr Lys Tyr Ser Phe Lys Gly Pro His Leu Val Gln 
1               5                   10                  15      


Ser Asp Gly Thr Val Pro Phe Trp Ala His Ala Gly Asn Ala Ile Pro 
            20                  25                  30          


Ser Ser Asp Gln 
        35      


<210>  15
<211>  49
<212>  PRT
<213>  Homo sapiens

<400>  15

Glu Tyr Lys Tyr Ser Phe Lys Gly Pro His Leu Val Gln Ser Asp Gly 
1               5                   10                  15      


Thr Val Pro Phe Trp Ala His Ala Gly Asn Ala Ile Pro Ser Ser Asp 
            20                  25                  30          


Gln Ile Arg Val Ala Pro Ser Leu Lys Ser Gln Arg Gly Ser Val Trp 
        35                  40                  45              


Thr 
    


<210>  16
<211>  123
<212>  PRT
<213>  Homo sapiens

<400>  16

Pro Ala Val Ala Leu Pro His Arg Arg Phe Glu Tyr Lys Tyr Ser Phe 
1               5                   10                  15      


Lys Gly Pro His Leu Val Gln Ser Asp Gly Thr Val Pro Phe Trp Ala 
            20                  25                  30          


His Ala Gly Asn Ala Ile Pro Ser Ser Asp Gln Ile Arg Val Ala Pro 
        35                  40                  45              


Ser Leu Lys Ser Gln Arg Gly Ser Val Trp Thr Lys Thr Lys Ala Ala 
    50                  55                  60                  


Phe Glu Asn Trp Glu Val Glu Val Thr Phe Arg Val Thr Gly Arg Gly 
65                  70                  75                  80  


Arg Ile Gly Ala Asp Gly Leu Ala Ile Trp Tyr Ala Glu Asn Gln Gly 
                85                  90                  95      


Leu Glu Gly Pro Val Phe Gly Ser Ala Asp Leu Trp Asn Gly Val Gly 
            100                 105                 110         


Ile Phe Phe Asp Ser Phe Asp Asn Asp Gly Lys 
        115                 120             


