                         SEQUENCE LISTING

<110>  Warp Drive Bio, Inc.
 
<120>  COMPOSITIONS AND METHODS FOR THE PRODUCTION OF COMPOUNDS

<130>  50869-009WO2

<140>  PCT/US17/27215
<141>  2017-04-12

<150>  US 62/321,439
<151>  2016-04-12

<160>  112   

<170>  PatentIn version 3.5

<210>  1
<211>  914
<212>  PRT
<213>  Streptomyces hygroscopicus

<400>  1

Met Pro Ala Val Glu Ser Tyr Glu Leu Asp Ala Arg Asp Asp Glu Leu 
1               5                   10                  15      


Arg Arg Leu Glu Glu Ala Val Gly Gln Ala Gly Asn Gly Arg Gly Val 
            20                  25                  30          


Val Val Thr Ile Thr Gly Pro Ile Ala Cys Gly Lys Thr Glu Leu Leu 
        35                  40                  45              


Asp Ala Ala Ala Ala Lys Ser Asp Ala Ile Thr Leu Arg Ala Val Cys 
    50                  55                  60                  


Ser Glu Glu Glu Arg Ala Leu Pro Tyr Ala Leu Ile Gly Gln Leu Ile 
65                  70                  75                  80  


Asp Asn Pro Ala Val Ala Ser Gln Leu Pro Asp Pro Val Ser Met Ala 
                85                  90                  95      


Leu Pro Gly Glu His Leu Ser Pro Glu Ala Glu Asn Arg Leu Arg Gly 
            100                 105                 110         


Asp Leu Thr Arg Thr Leu Leu Ala Leu Ala Ala Glu Arg Pro Val Leu 
        115                 120                 125             


Ile Gly Ile Asp Asp Met His His Ala Asp Thr Ala Ser Leu Asn Cys 
    130                 135                 140                 


Leu Leu His Leu Ala Arg Arg Val Gly Pro Ala Arg Ile Ala Met Val 
145                 150                 155                 160 


Leu Thr Glu Leu Arg Arg Leu Thr Pro Ala His Ser Gln Phe His Ala 
                165                 170                 175     


Glu Leu Leu Ser Leu Gly His His Arg Glu Ile Ala Leu Arg Pro Leu 
            180                 185                 190         


Gly Pro Lys His Ile Ala Glu Leu Ala Arg Ala Gly Leu Gly Pro Asp 
        195                 200                 205             


Val Asp Glu Asp Val Leu Thr Gly Leu Tyr Arg Ala Thr Gly Gly Asn 
    210                 215                 220                 


Leu Asn Leu Gly His Gly Leu Ile Lys Asp Val Arg Glu Ala Trp Ala 
225                 230                 235                 240 


Thr Gly Gly Thr Gly Ile Asn Ala Gly Arg Ala Tyr Arg Leu Ala Tyr 
                245                 250                 255     


Leu Gly Ser Leu Tyr Arg Cys Gly Pro Val Pro Leu Arg Val Ala Arg 
            260                 265                 270         


Val Ala Ala Val Leu Gly Gln Ser Ala Asn Thr Thr Leu Val Arg Trp 
        275                 280                 285             


Ile Ser Gly Leu Asn Ala Asp Ala Val Gly Glu Ala Thr Glu Ile Leu 
    290                 295                 300                 


Thr Glu Gly Gly Leu Leu His Asp Leu Arg Phe Pro His Pro Ala Ala 
305                 310                 315                 320 


Arg Ser Val Val Leu Asn Asp Leu Ser Ala Arg Glu Arg Arg Arg Leu 
                325                 330                 335     


His Arg Ser Ala Leu Glu Val Leu Asp Asp Val Pro Val Glu Val Val 
            340                 345                 350         


Ala His His Gln Ala Gly Ala Gly Phe Ile His Gly Pro Lys Ala Ala 
        355                 360                 365             


Glu Ile Phe Ala Lys Ala Gly Gln Glu Leu His Val Arg Gly Glu Leu 
    370                 375                 380                 


Asp Ala Ala Ser Asp Tyr Leu Gln Leu Ala His His Ala Ser Asp Asp 
385                 390                 395                 400 


Ala Val Thr Arg Ala Ala Leu Arg Val Glu Ala Val Ala Ile Glu Arg 
                405                 410                 415     


Arg Arg Asn Pro Leu Ala Ser Ser Arg His Leu Asp Glu Leu Thr Val 
            420                 425                 430         


Ala Ala Arg Ala Gly Leu Leu Ser Leu Glu His Ala Ala Leu Met Ile 
        435                 440                 445             


Arg Trp Leu Ala Leu Gly Gly Arg Ser Gly Glu Ala Ala Glu Val Leu 
    450                 455                 460                 


Ala Ala Gln Arg Pro Arg Ala Val Thr Asp Gln Asp Arg Ala His Leu 
465                 470                 475                 480 


Arg Ala Ala Glu Val Ser Leu Ala Leu Val Ser Pro Gly Ala Ser Gly 
                485                 490                 495     


Val Ser Pro Gly Ala Ser Gly Pro Asp Arg Arg Pro Arg Pro Leu Pro 
            500                 505                 510         


Pro Asp Glu Leu Ala Asn Leu Pro Lys Ala Ala Arg Leu Cys Ala Ile 
        515                 520                 525             


Ala Asp Asn Ala Val Ile Ser Ala Leu His Gly Arg Pro Glu Leu Ala 
    530                 535                 540                 


Ser Ala Glu Ala Glu Asn Val Leu Lys Gln Ala Asp Ser Ala Ala Asp 
545                 550                 555                 560 


Gly Ala Thr Ala Leu Ser Ala Leu Thr Ala Leu Leu Tyr Ala Glu Asn 
                565                 570                 575     


Thr Asp Thr Ala Gln Leu Trp Ala Asp Lys Leu Val Ser Glu Thr Gly 
            580                 585                 590         


Ala Ser Asn Glu Glu Glu Gly Ala Gly Tyr Ala Gly Pro Arg Ala Glu 
        595                 600                 605             


Thr Ala Leu Arg Arg Gly Asp Leu Ala Ala Ala Val Glu Ala Gly Ser 
    610                 615                 620                 


Ala Ile Leu Asp His Arg Arg Gly Ser Leu Leu Gly Ile Thr Ala Ala 
625                 630                 635                 640 


Leu Pro Leu Ser Ser Ala Val Ala Ala Ala Ile Arg Leu Gly Glu Thr 
                645                 650                 655     


Glu Arg Ala Glu Lys Trp Leu Ala Glu Pro Leu Pro Glu Ala Ile Arg 
            660                 665                 670         


Asp Ser Leu Phe Gly Leu His Leu Leu Ser Ala Arg Gly Gln Tyr Cys 
        675                 680                 685             


Leu Ala Thr Gly Arg His Glu Ser Ala Tyr Thr Ala Phe Arg Thr Cys 
    690                 695                 700                 


Gly Glu Arg Met Arg Asn Trp Gly Val Asp Val Pro Gly Leu Ser Leu 
705                 710                 715                 720 


Trp Arg Val Asp Ala Ala Glu Ala Leu Leu His Gly Arg Asp Arg Asp 
                725                 730                 735     


Glu Gly Arg Arg Leu Ile Asp Glu Gln Leu Thr His Ala Met Gly Pro 
            740                 745                 750         


Arg Ser Arg Ala Leu Thr Leu Arg Val Gln Ala Ala Tyr Ser Pro Gln 
        755                 760                 765             


Ala Gln Arg Val Asp Leu Leu Glu Glu Ala Ala Asp Leu Leu Leu Ser 
    770                 775                 780                 


Cys Asn Asp Gln Tyr Glu Arg Ala Arg Val Leu Ala Asp Leu Ser Glu 
785                 790                 795                 800 


Ala Phe Ser Ala Leu Arg His His Ser Arg Ala Arg Gly Leu Leu Arg 
                805                 810                 815     


Gln Ala Arg His Leu Ala Ala Gln Cys Gly Ala Thr Pro Leu Leu Arg 
            820                 825                 830         


Arg Leu Gly Ala Lys Pro Gly Gly Pro Gly Trp Leu Glu Glu Ser Gly 
        835                 840                 845             


Leu Pro Gln Arg Ile Lys Ser Leu Thr Asp Ala Glu Arg Arg Val Ala 
    850                 855                 860                 


Ser Leu Ala Ala Gly Gly Gln Thr Asn Arg Val Ile Ala Asp Gln Leu 
865                 870                 875                 880 


Phe Val Thr Ala Ser Thr Val Glu Gln His Leu Thr Asn Val Phe Arg 
                885                 890                 895     


Lys Leu Gly Val Lys Gly Arg Gln His Leu Pro Ala Glu Leu Ala Asn 
            900                 905                 910         


Ala Glu 
        


<210>  2
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  2
ctagggggtt gc                                                           12


<210>  3
<211>  6
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  3
gggggt                                                                   6


<210>  4
<211>  2685
<212>  DNA
<213>  Streptomyces hygroscopicus

<400>  4
atgcctgccg tggagtgcta tgaactggac gcccgcgatg acgagctcag aaaactggag       60

gaggttgtga ccgggcgggc caacggccgg ggtgtggtgg tcaccatcac cggaccgatc      120

gcctgcggca agaccgaact gctcgacgca gccgccgcga aggccgacgc catcacgtta      180

cgagcggtct gctccgcgga ggaacaggca ctcccgtacg ccctgatcgg gcagctcatc      240

gacaacccgg cgctcgcctc ccacgcgctg gagccggcct gcccgaccct cccgggcgag      300

cacctgtcgc cggaggccga gaaccggctg cgcagcgacc tcacccgtac cctgctggcg      360

ctcgccgccg aacggccggt gctgatcggc atcgacgagt cacacgcgaa cgctttgtgt      420

ctgctccacc tggcccgaag ggtcggctcg gcccggatcg ccatggtcct caccgagttg      480

cgccggctca ccccggccca ctcacagttc caggccgagc tgctcagcct ggggcaccac      540

cgcgagatcg cgctgcgccc gctcagcccg aagcacaccg ccgagctggt ccgcgccggt      600

ctcggtcccg acgtcgacga ggacgtgctc acggggttgt accgggcgac cggcggcaac      660

ctgaacctca cccgcggact gatcaacgat gtgcgggagg cctgggagac gggagggacg      720

ggcatcagcg cgggccgcgc gtaccggctg gcatacctcg gttccctcta ccgctgcggc      780

ccggtcccgt tgcgggtcgc acgggtggcc gccgtgctgg gccagagcgc caacaccacc      840

ctggtgcgct ggatcagcgg gctcaacgcg gacgcggtgg gcgaggcaac cgagatcctc      900

accgaaggcg gcctgctgca cgacctgcgg ttcccgcacc cggcggcccg ttcggtggta      960

ctcaacgaca tgtccgccca ggaacgacgc cgcctgcacc ggtccgctct ggaagtgctg     1020

gacgacgtgc ccgtggaagt ggtcgcgcac caccaggtcg gcgccggtct cctgcacggc     1080

ccgaaggccg ccgagatatt cgccaaggcc ggccaggagc tgcatgtgcg cggcgagttg     1140

gacaccgcgt ccgactatct gcaactggcc caccaggcct ccgacgacgc cgtcaccggg     1200

atgcgggccg aggccgtggc gatcgagcgc cgccgcaacc cgctggcctc gagccggcac     1260

ctcgacgagc tgaccgtcgt cgcccgtgcc gggctgctct tccccgagca cacggcgctg     1320

atgatccgct ggctgggcgt cggcgggcgg tccggcgagg cagccgggct gctggcctcg     1380

cagcgccccc gtgcggtcac cgaccaggac agggcccata tgcgggccgc cgaggtatcg     1440

ctcgcgctgg tcagccccgg cacgtccggc ccggaccggc ggccgcgtcc gctcacgccg     1500

gatgagctcg cgaacctgcc gaaggcggcc cggctctgcg cgatcgccga caatgccgtc     1560

atgtcggccc tgcgcggtcg tcccgagctc gccgcggccg aggcggagaa cgtcctgcag     1620

cacgccgact cggcggcggc cggcaccacc gccctcgccg cgctgaccgc cttgctgtac     1680

gcggagaaca ccgacaccgc tcagctctgg gccgacaagc tggtctccga gaccggggcg     1740

tcgaacgagg aggaggcggg ctacgcgggg ccgcgcgccg aagccgcgtt gcgtcgcggc     1800

gacctggccg cggcggtcga ggcaggcagc accgttctgg accaccggcg gctctcgacg     1860

ctcggcatca ccgccgcgct accgctgagc agcgcggtgg ccgccgccat ccggctgggc     1920

gagaccgagc gggcggagaa gtggctcgcc cagccgctgc cgcaggccat ccaggacggc     1980

ctgttcggcc tgcacctgct ctcggcgcgc ggccagtaca gcctcgccac gggccagcac     2040

gagtcggcgt acacggcgtt tcgcacctgc ggggaacgta tgcggaactg gggcgttgac     2100

gtgccgggtc tgtccctgtg gcgcgtcgac gccgccgagg cgctgctgca cggccgcgac     2160

cgggacgagg gccgacggct cgtcgacgag caactcaccc gtgcgatggg accccgttcc     2220

cgcgccttga cgctgcgggt gcaggcggcg tacagcccgc cggcgaagcg ggtcgacctg     2280

ctcgatgaag cggccgacct gctgctctcc tgcaacgacc agtacgagcg ggcacgggtg     2340

ctcgccgacc tgagcgagac gttcagcgcg ctccggcacc acagccgggc gcggggactg     2400

cttcggcagg cccggcacct ggccgcccag cgcggcgcga taccgctgct gcgccgactc     2460

ggggccaagc ccggaggccc cggctggctg gaggaatccg gcctgccgca gcggatcaag     2520

tcgctgaccg acgcggagcg gcgggtggcg tcgctggccg ccggcggaca gaccaaccgc     2580

gtgatcgccg accagctctt cgtcacggcc agcacggtgg agcagcacct cacggacgtc     2640

tccactgggt caaggccgcc agcacctgcc gccgaactcg tctag                     2685


<210>  5
<211>  2685
<212>  DNA
<213>  Streptomyces hygroscopicus

<400>  5
atgcctgccg tggagtgcta tgaactggac gcccgcgatg acgagctcag aaaactggag       60

gaggttgtga ccgggcgggc caacggccgg ggtgtggtgg tcaccatcac cggaccgatc      120

gcctgcggca agaccgaact gctcgacgca gccgccgcga aggccgacgc catcacgctg      180

cgagcggtct gctccgcgga ggaacaggca ctcccgtacg ccctgatcgg gcagctcatc      240

gacaacccgg cgctcgcctc ccacgcgctg gagccggcct gcccgaccct cccgggcgag      300

cacctgtcgc cggaggccga gaaccggctg cgcagcgacc tcacccgtac cctgctggcg      360

ctcgccgccg aacggccggt gctgatcggc atcgacgagt cacacgcgaa cgctttgtgt      420

ctgctccacc tggcccgaag ggtcggctcg gcccggatcg ccatggtcct caccgagttg      480

cgccggctca ccccggccca ctcacagttc caggccgagc tgctcagcct ggggcaccac      540

cgcgagatcg cgctgcgccc gctcagcccg aagcacaccg ccgagctggt ccgcgccggt      600

ctcggtcccg acgtcgacga ggacgtgctc acggggttgt accgggcgac cggcggcaac      660

ctgaacctca cccgcggact gatcaacgat gtgcgggagg cctgggagac gggagggacg      720

ggcatcagcg cgggccgcgc gtaccggctg gcatacctcg gttccctcta ccgctgcggc      780

ccggtcccgt tgcgggtcgc acgggtggcc gccgtgctgg gccagagcgc caacaccacc      840

ctggtgcgct ggatcagcgg gctcaacgcg gacgcggtgg gcgaggcaac cgagatcctc      900

accgaaggcg gcctgctgca cgacctgcgg ttcccgcacc cggcggcccg ttcggtggta      960

ctcaacgaca tgtccgccca ggaacgacgc cgcctgcacc ggtccgctct ggaagtgctg     1020

gacgacgtgc ccgtggaagt ggtcgcgcac caccaggtcg gcgccggtct cctgcacggc     1080

ccgaaggccg ccgagatatt cgccaaggcc ggccaggagc tgcatgtgcg cggcgagttg     1140

gacaccgcgt ccgactatct gcaactggcc caccaggcct ccgacgacgc cgtcaccggg     1200

atgcgggccg aggccgtggc gatcgagcgc cgccgcaacc cgctggcctc gagccggcac     1260

ctcgacgagc tgaccgtcgt cgcccgtgcc gggctgctct tccccgagca cacggcgctg     1320

atgatccgct ggctgggcgt cggcgggcgg tccggcgagg cagccgggct gctggcctcg     1380

cagcgccccc gtgcggtcac cgaccaggac agggcccata tgcgggccgc cgaggtatcg     1440

ctcgcgctgg tcagccccgg cacgtccggc ccggaccggc ggccgcgtcc gctcacgccg     1500

gatgagctcg cgaacctgcc gaaggcggcc cggctctgcg cgatcgccga caatgccgtc     1560

atgtcggccc tgcgcggtcg tcccgagctc gccgcggccg aggcggagaa cgtcctgcag     1620

cacgccgact cggcggcggc cggcaccacc gccctcgccg cgctgaccgc cttgctgtac     1680

gcggagaaca ccgacaccgc tcagctctgg gccgacaagc tggtctccga gaccggggcg     1740

tcgaacgagg aggaggcggg ctacgcgggg ccgcgcgccg aagccgcgtt gcgtcgcggc     1800

gacctggccg cggcggtcga ggcaggcagc accgttctgg accaccggcg gctctcgacg     1860

ctcggcatca ccgccgcgct accgctgagc agcgcggtgg ccgccgccat ccggctgggc     1920

gagaccgagc gggcggagaa gtggctcgcc cagccgctgc cgcaggccat ccaggacggc     1980

ctgttcggcc tgcacctgct ctcggcgcgc ggccagtaca gcctcgccac gggccagcac     2040

gagtcggcgt acacggcgtt tcgcacctgc ggggaacgta tgcggaactg gggcgttgac     2100

gtgccgggtc tgtccctgtg gcgcgtcgac gccgccgagg cgctgctgca cggccgcgac     2160

cgggacgagg gccgacggct cgtcgacgag caactcaccc gtgcgatggg accccgttcc     2220

cgcgccttga cgctgcgggt gcaggcggcg tacagcccgc cggcgaagcg ggtcgacctg     2280

ctcgatgaag cggccgacct gctgctctcc tgcaacgacc agtacgagcg ggcacgggtg     2340

ctcgccgacc tgagcgagac gttcagcgcg ctccggcacc acagccgggc gcggggactg     2400

cttcggcagg cccggcacct ggccgcccag cgcggcgcga taccgctgct gcgccgactc     2460

ggggccaagc ccggaggccc cggctggctg gaggaatccg gcctgccgca gcggatcaag     2520

tcgctgaccg acgcggagcg gcgggtggcg tcgctggccg ccggcggaca gaccaaccgc     2580

gtgatcgccg accagctctt cgtcacggcc agcacggtgg agcagcacct cacggacgtc     2640

tccactgggt caaggccgcc agcacctgcc gccgaactcg tctag                     2685


<210>  6
<211>  2772
<212>  DNA
<213>  Streptomyces kanamyceticus

<400>  6
gtggttcctg aagtgcgagc agcccccgac gaactgatcg cccgcgatga cgagctgagc       60

cgcctccaac gggcactcac cagggcgggg agcggaaggg gcggcgtcgt cgccatcacc      120

gggcccatcg ccagcggaaa gacggcgctg ctcgacgccg gagcggccaa gtccggcttc      180

gtcgcactcc gtgcggtgtg ctcctgggaa gagcgcactc tgccgtacgg gatgctgggc      240

cagctcttcg accatcccga actggccgcc caggcgccgg accttgccca cttcacggct      300

tcgtgcgaga gccctcaggc cggtaccgac aaccgcctgc gggccgagtt cacccgcacc      360

ctgctggcgc tcgccgcgga ctggcccgtc ctgatcggca tcgacgacgt gcaccacgcc      420

gacgcggaat cactgcgctg tctgctccac ctcgcccgcc gcatcggccc ggcccgcatc      480

gcggtcgtac tgaccgagct gcgcagaccg acgcccgccg actcccgctt ccaggcggaa      540

ctgctgagcc tgcgctccta ccaggagatc gcgctcagac cgctcaccga ggcgcagacc      600

ggcgaactcg tacgtcggca cctcggcgcg gagacccacg aggacgtctc cgccgatacg      660

ttccgggcga ccggcgggaa cctgctcctc gggcacggtt tgatcaatga catccgggag      720

gcgcggacag cgggacggcc gggggtcgtc gcggggcggg cgtaccggct cgcgtacctc      780

agctcgctct accgctgcgg cccgagcgcg ctgcgtgtcg cccgggcgtc cgccgtgctc      840

ggcgcgagcg ccgaagccgt gctcgtccag cggatgaccg gactgaacaa ggacgcggtc      900

gaacaggtct atgagcagct gaacgaggga cggctgctgc agggcgagcg gtttccgcac      960

ccggcggccc gctccatcgt ccttgacgac ctgtcggccc tggaacgcag aaacctgcac     1020

gagtcggcgc tggagctgct gcgggaccac ggcgtggccg gcaacgtgct cgcccgccac     1080

cagatcggcg ccggccgggt gcacggcgag gaggccgtcg agctgttcac cggggccgca     1140

cgggagcacc acctgcgcgg tgaactggac gacgcggccg gatacctgga actcgcccac     1200

cgtgcctccg acgaccccgt cacgcgcgcc gcactacgcg tcggcgccgc cgcgatcgag     1260

cgcctctgca atccggtacg ggcaggccgg catctgcccg agctgctcac cgcgtcgcgc     1320

gcgggactgc tctccagcga gcacgccgtg tcgctcgccg actggctggc gatgggcggg     1380

cgcccgggcg aggcggccga ggtcctcgcg acgcagcgtc ccgcggccga cagcgagcag     1440

caccgcgcac tcctgcgcag cggcgagttg tccctcgcgc tggtccaccc cggcgcgtgg     1500

gatccgttgc gccggaccga tcggttcgcc gcgggcgggc tcggctcgct tcccggaccc     1560

gcccggcacc gcgcggtcgc cgaccaagcc gtcatcgcgg cgctgcgtgg acgtctcgac     1620

cgggcggacg ccaacgcgga gagcgttctc cagcacaccg acgccacggc ggaccggacc     1680

acggccatca tggcgttgct ggccctgctc tacgcggaga acaccgatgc tgtccagttc     1740

tgggtcgaca aactggccgg tgacgagggc accaggacac cggccgacga ggcggtccac     1800

gcggggttca acgccgagat cgcgctgcgc cgcggcgact tgatgagagc cgtcgagtac     1860

ggcgaggcag cgctcggcca ccggcacctg cccacctggg gaatggccgc cgctctgccg     1920

ctgagcagca ccgtggttgc cgcgatccgg ctcggcgacc tcgacagggc cgagcggtgg     1980

ctcgccgagc cgctgccgca gcagacgccg gagagcctct tcgggctgca cctgctctgg     2040

gcccgcgggc agcaccacct cgcgaccggg cggcacgggg cggcgtacac ggcgttcagg     2100

gaatgcggcg agcggatgcg gcggtgggcc gtcgacgtgc cgggcctggc cctgtggcgg     2160

gtcgacgccg ccgaatcgct gctgctgctc ggccgtgacc gtgccgaagg actgcggctc     2220

gtctccgagc agctgtcccg gccgatgcgc cctcgcgcgc gcgtgcagac gttacgggta     2280

caggcggcct acagtccgcc gccccaacgg atcgacctgc tcgaagaggc cgccgacctg     2340

ctggtcacct gcaacgacca gtacgaactg gcaaacgtac tcagcgactt ggcagaggcc     2400

tccagcatgg tccggcagca cagcagggcg cggggtctgc tccgccgggc acggcacctc     2460

gccacccagt gcggcgccgt gccgctcctg cggcggctcg gcgcggaacc ctcggacatc     2520

ggcggagcct gggacgcgac gctgggacag cggatcgcgt cactgacgga gtcggagcgg     2580

cgggtggccg cgctcgccgc ggtcgggcgt acgaacaggg agatcgccga gcagctgttc     2640

gtcacggcca gcacggtgga acagcacctc acgaacgtgt tccgcaaact ggcggtgaag     2700

ggccgccagc agcttccgaa ggaactggcc gacgtcggcg agccggcgga ccgcgaccgc     2760

cggtgcgggt ag                                                         2772


<210>  7
<211>  2772
<212>  DNA
<213>  Streptomyces kanamyceticus

<400>  7
atggttcctg aagtgcgagc agcccccgac gaactgatcg cccgcgatga cgagctgagc       60

cgcctccaac gggcactcac cagggcgggg agcggaaggg gcggcgtcgt cgccatcacc      120

gggcccatcg ccagcggaaa gacggcgctg ctcgacgccg gagcggccaa gtccggcttc      180

gtcgcactcc gtgcggtgtg ctcctgggaa gagcgcactc tgccgtacgg gatgctgggc      240

cagctcttcg accatcccga actggccgcc caggcgccgg accttgccca cttcacggct      300

tcgtgcgaga gccctcaggc cggtaccgac aaccgcctgc gggccgagtt cacccgcacc      360

ctgctggcgc tcgccgcgga ctggcccgtc ctgatcggca tcgacgacgt gcaccacgcc      420

gacgcggaat cactgcgctg tctgctccac ctcgcccgcc gcatcggccc ggcccgcatc      480

gcggtcgtac tgaccgagct gcgcagaccg acgcccgccg actcccgctt ccaggcggaa      540

ctgctgagcc tgcgctccta ccaggagatc gcgctcagac cgctcaccga ggcgcagacc      600

ggcgaactcg tacgtcggca cctcggcgcg gagacccacg aggacgtctc cgccgatacg      660

ttccgggcga ccggcgggaa cctgctcctc gggcacggtt tgatcaatga catccgggag      720

gcgcggacag cgggacggcc gggggtcgtc gcggggcggg cgtaccggct cgcgtacctc      780

agctcgctct accgctgcgg cccgagcgcg ctgcgtgtcg cccgggcgtc cgccgtgctc      840

ggcgcgagcg ccgaagccgt gctcgtccag cggatgaccg gactgaacaa ggacgcggtc      900

gaacaggtct atgagcagct gaacgaggga cggctgctgc agggcgagcg gtttccgcac      960

ccggcggccc gctccatcgt ccttgacgac ctgtcggccc tggaacgcag aaacctgcac     1020

gagtcggcgc tggagctgct gcgggaccac ggcgtggccg gcaacgtgct cgcccgccac     1080

cagatcggcg ccggccgggt gcacggcgag gaggccgtcg agctgttcac cggggccgca     1140

cgggagcacc acctgcgcgg tgaactggac gacgcggccg gatacctgga actcgcccac     1200

cgtgcctccg acgaccccgt cacgcgcgcc gcactacgcg tcggcgccgc cgcgatcgag     1260

cgcctctgca atccggtacg ggcaggccgg catctgcccg agctgctcac cgcgtcgcgc     1320

gcgggactgc tctccagcga gcacgccgtg tcgctcgccg actggctggc gatgggcggg     1380

cgcccgggcg aggcggccga ggtcctcgcg acgcagcgtc ccgcggccga cagcgagcag     1440

caccgcgcac tcctgcgcag cggcgagttg tccctcgcgc tggtccaccc cggcgcgtgg     1500

gatccgttgc gccggaccga tcggttcgcc gcgggcgggc tcggctcgct tcccggaccc     1560

gcccggcacc gcgcggtcgc cgaccaagcc gtcatcgcgg cgctgcgtgg acgtctcgac     1620

cgggcggacg ccaacgcgga gagcgttctc cagcacaccg acgccacggc ggaccggacc     1680

acggccatca tggcgttgct ggccctgctc tacgcggaga acaccgatgc tgtccagttc     1740

tgggtcgaca aactggccgg tgacgagggc accaggacac cggccgacga ggcggtccac     1800

gcggggttca acgccgagat cgcgctgcgc cgcggcgact tgatgagagc cgtcgagtac     1860

ggcgaggcag cgctcggcca ccggcacctg cccacctggg gaatggccgc cgctctgccg     1920

ctgagcagca ccgtggttgc cgcgatccgg ctcggcgacc tcgacagggc cgagcggtgg     1980

ctcgccgagc cgctgccgca gcagacgccg gagagcctct tcgggctgca cctgctctgg     2040

gcccgcgggc agcaccacct cgcgaccggg cggcacgggg cggcgtacac ggcgttcagg     2100

gaatgcggcg agcggatgcg gcggtgggcc gtcgacgtgc cgggcctggc cctgtggcgg     2160

gtcgacgccg ccgaatcgct gctgctgctc ggccgtgacc gtgccgaagg actgcggctc     2220

gtctccgagc agctgtcccg gccgatgcgc cctcgcgcgc gcgtgcagac gctgcgggta     2280

caggcggcct acagtccgcc gccccaacgg atcgacctgc tcgaagaggc cgccgacctg     2340

ctggtcacct gcaacgacca gtacgaactg gcaaacgtac tcagcgactt ggcagaggcc     2400

tccagcatgg tccggcagca cagcagggcg cggggtctgc tccgccgggc acggcacctc     2460

gccacccagt gcggcgccgt gccgctcctg cggcggctcg gcgcggaacc ctcggacatc     2520

ggcggagcct gggacgcgac gctgggacag cggatcgcgt cactgacgga gtcggagcgg     2580

cgggtggccg cgctcgccgc ggtcgggcgt acgaacaggg agatcgccga gcagctgttc     2640

gtcacggcca gcacggtgga acagcacctc acgaacgtgt tccgcaaact ggcggtgaag     2700

ggccgccagc agcttccgaa ggaactggcc gacgtcggcg agccggcgga ccgcgaccgc     2760

cggtgcgggt ag                                                         2772


<210>  8
<211>  2742
<212>  DNA
<213>  Streptomyces ascomyceticus

<400>  8
gtgatagcgc gcttatctcc cccagacctg atcgcccgcg atgacgagtt cggttccctc       60

caccgggcgc tcacccgagc ggggggcggg cggggcgtcg tcgccgccgt caccgggccg      120

atcgcctgcg gcaagaccga actcctcgac gccgccgcgg ccaaggccgg cttcgtcacc      180

cttcgcgcgg tgtgctccat ggaggagcgg gccctgccgt acggcatgct cggccagctc      240

ctcgaccagc ccgagctggc cgcccggaca ccggagctgg tccggctgac ggcatcgtgc      300

gaaaacctgc cggccgacgt cgacaaccgc ctggggaccg aactcacccg cacggtgctg      360

acgctcgccg cggagcggcc cgtactgatc ggcatcgacg acgtgcacca cgccgacgcg      420

ccgtcgctgc gctgcctgct ccacctcgcg cgccgcatca gccgggcccg tgtcgccatc      480

gtgctgaccg agctgctccg gccgacgccc gcccactccc aattccgggc ggcactgctg      540

agtctgcgcc actaccagga gatcgcgctg cgcccgctca ccgaggcgca gaccaccgaa      600

ctcgtgcgcc ggcacctcgg ccaggacgcg cacgacgacg tggtggccca ggcgttccgg      660

gcgaccggcg gcaacctgct cctcggccac ggcctgatcg acgacatccg ggaggcacgg      720

acacggacct cagggtgcct ggaagtggtc gcggggcggg cgtaccggct cgcctacctc      780

gggtcgctct atcgttgcgg cccggccgcg ctgagcgtcg cccgagcttc cgccgtgctc      840

ggcgagagtg tcgaactcac cctcgtccag cggatgaccg gcctcgacac cgaggcggtc      900

gagcaggccc acgaacagct ggtcgagggg cggctgctgc gggaagggcg gttcccgcac      960

cccgcggccc gctccgtcgt actcgacgac ctctccgccg ccgagcggcg tggcctgcac     1020

gagctggcgc tggaactgct gcgggaccgc ggcgtggcca gcaaggtgct cgcccgccac     1080

cagatgggta ccggccgggt gcacggcgcc gaggtcgccg ggctgttcac cgacgccgcg     1140

cgcgagcacc acctgcgcgg cgagctcgac gaggccgtca cctacctgga gttcgcctac     1200

cgggcctccg acgaccccgc cgtccacgcc gcactgcgcg tcgacaccgc cgccatcgag     1260

cggctctgcg atcccgccag atccggccgg catgtgcccg agctgctcac cgcgtcgcgg     1320

gaacggctcc tctccagcga gcacgccgtg tcgctcgcct gctggctggc gatggacggg     1380

cggccgggcg aggccgccga ggtcctggcg gcccagcgct ccgccgcccc gagcgagcag     1440

ggccgggcgc acctgcgcgt cgcggacctg tccctcgcgc tgatctatcc cggcgcggcc     1500

gatccgccgc gtccggccga tccgccggcc gaggacgagg tcgcctcgtt ttccggagcc     1560

gtccggcacc gcgccgtcgc cgacaaggcc ctgagcaacg cgctgcgcgg ctggtccgaa     1620

caggccgagg ccaaagccga gtacgtgctc cagcactccc gggtcacgac ggaccggacc     1680

acgaccatga tggcgttgct ggccctgctc tacgccgagg acaccgatgc cgtccagtcc     1740

tgggtcgaca agctggccgg tgacgacaac atgcggaccc cggccgacga ggcggtccac     1800

gcggggttcc gcgccgaggc cgcgctgcgc cgcggcgacc tgaccgccgc cgtcgaatgc     1860

ggcgaggccg cgctcgcccc ccgggtcgtg ccctcctggg ggatggccgc cgcattgccg     1920

ctgagcagca ccgtggccgc cgcgatccga ctgggcgacc tggaccgggc ggagcggtgg     1980

ctcgccgagc cgttgccgga ggagacctcc gacagcctct tcggactgca catggtctgg     2040

gcccgtgggc aacaccatct cgcggccggg cggtaccggg cggcgtacaa cgcgttccgg     2100

gactgcgggg agcggatgcg acgctggtcc gtcgacgtgc cgggcctggc cctgtggcgg     2160

gtcgacgccg ccgaagcgct tctgctgctc ggccgcggcc gtgacgaggg gctgaggctc     2220

atctccgagc agctgtcccg gccgatgggg tcccgggcgc gggtgatgac gctgcgggtg     2280

caggcggcct acagtccgcc ggccaagcgg atcgaactgc tcgacgaggc cgccgatctg     2340

ctcatcatgt gccgcgacca gtacgagctg gcccgcgtcc tcgccgacat gggcgaagcg     2400

tgcggcatgc tccggcggca cagccgtgcg cggggactgt tccgccgcgc acggcacctc     2460

gcgacccagt gcggagccgt gccgctcctc cggcggctcg gtggggagtc ctcggacgcg     2520

gacggcaccc aggacgtgac gccggcgcag cggatcacat cgctgaccga ggcggagcgg     2580

cgggtggcgt cgcacgccgc ggtcgggcgc accaacaagg agatcgccag ccagctgttc     2640

gtcacctcca gcacggtgga acagcacctc accaacgtgt tccgcaagct gggggtgaag     2700

ggccgtcagc aactgcccaa ggaactgtcc gacgccggct ga                        2742


<210>  9
<211>  2742
<212>  DNA
<213>  Streptomyces ascomyceticus

<400>  9
atgatagcgc gcctgtctcc cccagacctg atcgcccgcg atgacgagtt cggttccctc       60

caccgggcgc tcacccgagc ggggggcggg cggggcgtcg tcgccgccgt caccgggccg      120

atcgcctgcg gcaagaccga actcctcgac gccgccgcgg ccaaggccgg cttcgtcacc      180

cttcgcgcgg tgtgctccat ggaggagcgg gccctgccgt acggcatgct cggccagctc      240

ctcgaccagc ccgagctggc cgcccggaca ccggagctgg tccggctgac ggcatcgtgc      300

gaaaacctgc cggccgacgt cgacaaccgc ctggggaccg aactcacccg cacggtgctg      360

acgctcgccg cggagcggcc cgtactgatc ggcatcgacg acgtgcacca cgccgacgcg      420

ccgtcgctgc gctgcctgct ccacctcgcg cgccgcatca gccgggcccg tgtcgccatc      480

gtgctgaccg agctgctccg gccgacgccc gcccactccc aattccgggc ggcactgctg      540

agtctgcgcc actaccagga gatcgcgctg cgcccgctca ccgaggcgca gaccaccgaa      600

ctcgtgcgcc ggcacctcgg ccaggacgcg cacgacgacg tggtggccca ggcgttccgg      660

gcgaccggcg gcaacctgct cctcggccac ggcctgatcg acgacatccg ggaggcacgg      720

acacggacct cagggtgcct ggaagtggtc gcggggcggg cgtaccggct cgcctacctc      780

gggtcgctct atcgttgcgg cccggccgcg ctgagcgtcg cccgagcttc cgccgtgctc      840

ggcgagagtg tcgaactcac cctcgtccag cggatgaccg gcctcgacac cgaggcggtc      900

gagcaggccc acgaacagct ggtcgagggg cggctgctgc gggaagggcg gttcccgcac      960

cccgcggccc gctccgtcgt actcgacgac ctctccgccg ccgagcggcg tggcctgcac     1020

gagctggcgc tggaactgct gcgggaccgc ggcgtggcca gcaaggtgct cgcccgccac     1080

cagatgggta ccggccgggt gcacggcgcc gaggtcgccg ggctgttcac cgacgccgcg     1140

cgcgagcacc acctgcgcgg cgagctcgac gaggccgtca cctacctgga gttcgcctac     1200

cgggcctccg acgaccccgc cgtccacgcc gcactgcgcg tcgacaccgc cgccatcgag     1260

cggctctgcg atcccgccag atccggccgg catgtgcccg agctgctcac cgcgtcgcgg     1320

gaacggctcc tctccagcga gcacgccgtg tcgctcgcct gctggctggc gatggacggg     1380

cggccgggcg aggccgccga ggtcctggcg gcccagcgct ccgccgcccc gagcgagcag     1440

ggccgggcgc acctgcgcgt cgcggacctg tccctcgcgc tgatctatcc cggcgcggcc     1500

gatccgccgc gtccggccga tccgccggcc gaggacgagg tcgcctcgtt ttccggagcc     1560

gtccggcacc gcgccgtcgc cgacaaggcc ctgagcaacg cgctgcgcgg ctggtccgaa     1620

caggccgagg ccaaagccga gtacgtgctc cagcactccc gggtcacgac ggaccggacc     1680

acgaccatga tggcgttgct ggccctgctc tacgccgagg acaccgatgc cgtccagtcc     1740

tgggtcgaca agctggccgg tgacgacaac atgcggaccc cggccgacga ggcggtccac     1800

gcggggttcc gcgccgaggc cgcgctgcgc cgcggcgacc tgaccgccgc cgtcgaatgc     1860

ggcgaggccg cgctcgcccc ccgggtcgtg ccctcctggg ggatggccgc cgcattgccg     1920

ctgagcagca ccgtggccgc cgcgatccga ctgggcgacc tggaccgggc ggagcggtgg     1980

ctcgccgagc cgttgccgga ggagacctcc gacagcctct tcggactgca catggtctgg     2040

gcccgtgggc aacaccatct cgcggccggg cggtaccggg cggcgtacaa cgcgttccgg     2100

gactgcgggg agcggatgcg acgctggtcc gtcgacgtgc cgggcctggc cctgtggcgg     2160

gtcgacgccg ccgaagcgct tctgctgctc ggccgcggcc gtgacgaggg gctgaggctc     2220

atctccgagc agctgtcccg gccgatgggg tcccgggcgc gggtgatgac gctgcgggtg     2280

caggcggcct acagtccgcc ggccaagcgg atcgaactgc tcgacgaggc cgccgatctg     2340

ctcatcatgt gccgcgacca gtacgagctg gcccgcgtcc tcgccgacat gggcgaagcg     2400

tgcggcatgc tccggcggca cagccgtgcg cggggactgt tccgccgcgc acggcacctc     2460

gcgacccagt gcggagccgt gccgctcctc cggcggctcg gtggggagtc ctcggacgcg     2520

gacggcaccc aggacgtgac gccggcgcag cggatcacat cgctgaccga ggcggagcgg     2580

cgggtggcgt cgcacgccgc ggtcgggcgc accaacaagg agatcgccag ccagctgttc     2640

gtcacctcca gcacggtgga acagcacctc accaacgtgt tccgcaagct gggggtgaag     2700

ggccgtcagc aactgcccaa ggaactgtcc gacgccggct ga                        2742


<210>  10
<211>  2706
<212>  DNA
<213>  Micromonospora sp. S92-306401

<400>  10
gtggagtttt acgacctggt cgcccgcgat gacgagctca gaaggttgga ccaggccctc       60

ggccgcgccg ccggcggacg gggtgtcgtg gtcaccgtca ccggaccggt cggctgcggc      120

aagaccgaac tgctggacgc ggccgcggcc gaggaggaat tcatcacgtt gcgtgcggtc      180

tgctcggccg aggagcgggc cctgccgtac gccgtgatcg gccaactcct cgaccatccc      240

gtactctccg cacgcgcgcc cgacctggcc tgcgtgacgg ctccgggccg gacgctgccg      300

gccgacaccg agaaccgcct gcgccgcgac ctcacccggg ccctgctggc cctggcctcc      360

gaacgaccgg ttctgatctg catcgacgac gtgcaccagg ccgacaccgc ctcgctgaac      420

tgcctgctgc acctggcccg gcgggtcgcc tcggcccgga tcgccatgat cctcaccgag      480

ttgcgccggc tcaccccggc tcactcccgg ttcgaggcgg aactgctcag cctgcggcac      540

cgccacgaga tcgcgctgcg tcccctcggc ccggccgaca ccgccgaact ggcccgcgcc      600

cggctcggcg ccggcgtcac cgccgacgag ctggcccagg tccacgaggc caccagcggg      660

aaccccaacc tggtcggagg cctggtcaac gacgtgcgag aggcctgggc ggccggtggc      720

acgggcattg cggcggggcg ggcgtaccgg ctggcgtacc tcagctccgt gtaccgctgt      780

ggtccggtcc cgttgcggat cgcccaggcg gcggcggtgc tgggtcccag cgccaccgtc      840

acgctggtgc gccggatcag cgggctcgac gccgagacgg tggacgaggc gaccgcgatc      900

ctcaccgagg gcggcctgct ccgggaccac cggttcccgc atccggcggc ccgctcggtc      960

gtactcgacg acatgtccgc gcaggaacgc cgccgcctgc accggtccac gctggacgtg     1020

ctggacggcg tacccgtcga cgtgctcgcg caccaccagg ccggcgccgg tctgctgcac     1080

ggcccgcagg cggccgagat gttcgcccgg gccagccagg agctgcgggt acgcggcgag     1140

ctggacgccg cgaccgagta cctgcaactg gcctaccggg cctccgacga cgccggcgcc     1200

cgggccgccc tgcaggtgga gaccgtggcc ggcgagcgcc gccgcaaccc gctggccgcc     1260

agccggcacc tggacgagct ggccgccgcc gcccgggccg gcctgctgtc ggccgagcac     1320

gccgccctgg tcgtgcactg gctggccgac gccggacgac ccggcgaggc cgccgaggtg     1380

ctggcgctgc agcgggcgct ggccgtcacc gaccacgacc gggcccgcct gcgggcggcc     1440

gaggtgtcgc tcgcgctgtt ccaccccggc gtccccggtt cggacccgcg gcccctcgcg     1500

ccggaggagc tcgcgagcct gtccctgtcg gcccggcacg gtgtgaccgc cgacaacgcg     1560

gtgctggcgg cgctgcgcgg ccgtcccgag tcggccgccg ccgaggcgga gaacgtgctg     1620

cgcaacgccg acgccgccgc gtccggcccg accgccctgg ccgcgctgac ggccctgctc     1680

tacgccgaga acaccgacgc cgcccagctc tgggcggaca agctggccgc gggcatcggg     1740

gcgggggagg gggaggccgg ctacgcgggg ccgcggaccg tggccgccct gcgtcgcggc     1800

gacctgacca ccgcggtcca ggcggccggc gcggtcctgg accgcggccg gccgtcgtcg     1860

ctcggcatca ccgccgtgtt gccgttgagc ggcgcggtcg ccgccgcgat ccggctgggc     1920

gagctcgagc gggccgagaa gtggctggcc gagccgctgc ccgaagccgt ccacgacagc     1980

ctgttcggcc tgcacctgct gatggcgcgg ggccgctaca gcctcgcggt gggccggcac     2040

gaggcggcgt acgccgcgtt ccgggactgc ggtgaacgga tgcgccggtg ggacgtcgac     2100

gtgcccgggc tggccctgtg gcgggtggac gcggccgagg cgctgctgcc cggcgatgac     2160

cgggcggagg gccggcggct gatcgacgag cagctcaccc ggccgatggg gccccggtca     2220

cgagccctga ccctgcgggt acgagcggcc tacgccccgc cggcgaaacg gatcgacctg     2280

ctcgacgaag cggccgacct gctgctctcc agcaacgacc agtacgagcg ggcacgggtg     2340

ctggccgacc tgagcgaggc gttcagcgcg ctccggcaga acggccgggc gcgcggcatc     2400

ctgcggcagg cccggcacct ggccgcccag tgcggggcgg tccccctgct gcgccggctg     2460

ggcgtcaagg ccggccggtc cggtcggctc ggccggccgc cgcagggaat ccgctccctg     2520

accgaggccg agcgccgggt ggccacgctg gccgccgccg ggcagaccaa ccgggagatc     2580

gccgaccagc tcttcgtcac cgccagcacg gtcgagcagc acctcaccaa cgtgttccgc     2640

aagctcggcg tgaagggccg ccagcaattg ccggccgagc tggccgacct gcggccgccg     2700

ggctga                                                                2706


<210>  11
<211>  2706
<212>  DNA
<213>  Micromonospora sp. S92-306401

<400>  11
atggagtttt acgacctggt cgcccgcgat gacgagctca gaaggttgga ccaggccctc       60

ggccgcgccg ccggcggacg gggtgtcgtg gtcaccgtca ccggaccggt cggctgcggc      120

aagaccgaac tgctggacgc ggccgcggcc gaggaggaat tcatcacgtt gcgtgcggtc      180

tgctcggccg aggagcgggc cctgccgtac gccgtgatcg gccaactcct cgaccatccc      240

gtactctccg cacgcgcgcc cgacctggcc tgcgtgacgg ctccgggccg gacgctgccg      300

gccgacaccg agaaccgcct gcgccgcgac ctcacccggg ccctgctggc cctggcctcc      360

gaacgaccgg ttctgatctg catcgacgac gtgcaccagg ccgacaccgc ctcgctgaac      420

tgcctgctgc acctggcccg gcgggtcgcc tcggcccgga tcgccatgat cctcaccgag      480

ttgcgccggc tcaccccggc tcactcccgg ttcgaggcgg aactgctcag cctgcggcac      540

cgccacgaga tcgcgctgcg tcccctcggc ccggccgaca ccgccgaact ggcccgcgcc      600

cggctcggcg ccggcgtcac cgccgacgag ctggcccagg tccacgaggc caccagcggg      660

aaccccaacc tggtcggagg cctggtcaac gacgtgcgag aggcctgggc ggccggtggc      720

acgggcattg cggcggggcg ggcgtaccgg ctggcgtacc tcagctccgt gtaccgctgt      780

ggtccggtcc cgttgcggat cgcccaggcg gcggcggtgc tgggtcccag cgccaccgtc      840

acgctggtgc gccggatcag cgggctcgac gccgagacgg tggacgaggc gaccgcgatc      900

ctcaccgagg gcggcctgct ccgggaccac cggttcccgc atccggcggc ccgctcggtc      960

gtactcgacg acatgtccgc gcaggaacgc cgccgcctgc accggtccac gctggacgtg     1020

ctggacggcg tacccgtcga cgtgctcgcg caccaccagg ccggcgccgg tctgctgcac     1080

ggcccgcagg cggccgagat gttcgcccgg gccagccagg agctgcgggt acgcggcgag     1140

ctggacgccg cgaccgagta cctgcaactg gcctaccggg cctccgacga cgccggcgcc     1200

cgggccgccc tgcaggtgga gaccgtggcc ggcgagcgcc gccgcaaccc gctggccgcc     1260

agccggcacc tggacgagct ggccgccgcc gcccgggccg gcctgctgtc ggccgagcac     1320

gccgccctgg tcgtgcactg gctggccgac gccggacgac ccggcgaggc cgccgaggtg     1380

ctggcgctgc agcgggcgct ggccgtcacc gaccacgacc gggcccgcct gcgggcggcc     1440

gaggtgtcgc tcgcgctgtt ccaccccggc gtccccggtt cggacccgcg gcccctcgcg     1500

ccggaggagc tcgcgagcct gtccctgtcg gcccggcacg gtgtgaccgc cgacaacgcg     1560

gtgctggcgg cgctgcgcgg ccgtcccgag tcggccgccg ccgaggcgga gaacgtgctg     1620

cgcaacgccg acgccgccgc gtccggcccg accgccctgg ccgcgctgac ggccctgctc     1680

tacgccgaga acaccgacgc cgcccagctc tgggcggaca agctggccgc gggcatcggg     1740

gcgggggagg gggaggccgg ctacgcgggg ccgcggaccg tggccgccct gcgtcgcggc     1800

gacctgacca ccgcggtcca ggcggccggc gcggtcctgg accgcggccg gccgtcgtcg     1860

ctcggcatca ccgccgtgtt gccgttgagc ggcgcggtcg ccgccgcgat ccggctgggc     1920

gagctcgagc gggccgagaa gtggctggcc gagccgctgc ccgaagccgt ccacgacagc     1980

ctgttcggcc tgcacctgct gatggcgcgg ggccgctaca gcctcgcggt gggccggcac     2040

gaggcggcgt acgccgcgtt ccgggactgc ggtgaacgga tgcgccggtg ggacgtcgac     2100

gtgcccgggc tggccctgtg gcgggtggac gcggccgagg cgctgctgcc cggcgatgac     2160

cgggcggagg gccggcggct gatcgacgag cagctcaccc ggccgatggg gccccggtca     2220

cgagccctga ccctgcgggt acgagcggcc tacgccccgc cggcgaaacg gatcgacctg     2280

ctcgacgaag cggccgacct gctgctctcc agcaacgacc agtacgagcg ggcacgggtg     2340

ctggccgacc tgagcgaggc gttcagcgcg ctccggcaga acggccgggc gcgcggcatc     2400

ctgcggcagg cccggcacct ggccgcccag tgcggggcgg tccccctgct gcgccggctg     2460

ggcgtcaagg ccggccggtc cggtcggctc ggccggccgc cgcagggaat ccgctccctg     2520

accgaggccg agcgccgggt ggccacgctg gccgccgccg ggcagaccaa ccgggagatc     2580

gccgaccagc tcttcgtcac cgccagcacg gtcgagcagc acctcaccaa cgtgttccgc     2640

aagctcggcg tgaagggccg ccagcaattg ccggccgagc tggccgacct gcggccgccg     2700

ggctga                                                                2706


<210>  12
<211>  2616
<212>  DNA
<213>  Streptomyces violaceusniger

<400>  12
gtggtcaccg tcaccggccc aatcgcctgc ggcaagacag aactgcttga cgcggctgcc       60

gcgaaggctg aggccatcat tctgcgcgcg gtctgcgcgc cagaagagcg ggctatgccg      120

tacgccatga tcgggcagct catcgacgac ccggcgctcg cgcatcgggc gccggggctg      180

gctgatcgga tagcccaggg cgggcagctg tcgctgaggg ccgagaaccg actgcgcagg      240

gatctcaccc gtgccctgct ggcgcttgcc gtcgaccggc ctgtgctgat cggcgtcgac      300

gatgtgcatc acgccgacac cgcctctttg aactgtctgc tgcatttggc gcgccgggtc      360

cgtccggccc ggatatccat gatcttcacc gagttgcgca gcctcacccc tactcagtca      420

cggttcaagg cggagctgct cagcctgccg taccaccacg agatcgcgct gcgtccgttc      480

ggaccggagc aatcggcgga gctggcccgc gccgccttcg gcccgggcct cgccgaggat      540

gtgctcgtgg ggttgtataa aacgaccagg ggcaatctga gtctcagccg tggactgatc      600

agcgatgtgc gggaggccct ggccaacgga gagagcgcct tcgaggcggg ccgcgcgttc      660

cggctggcgt acctcggctc gctctaccgc tgtggcccgg tcgcgctgcg ggtcgcccga      720

gtggctgccg tgctgggccc gagcgccacc accacgctgg tgcgccgtct aagcgggctc      780

agcgcggaga cgatagaccg ggcaaccaag atcctcaccg agggcgggct gctgctcgac      840

cagcagttcc cgcacccggc cgcccgctcg gtggtgcttg atgacatgtc cgcccaggaa      900

cgacgcggcc tgcacactct cgccctggaa ctgctggacg aggcgccggt tgaagtgctc      960

gcgcaccacc aggtcggcgc cggtctcata cacgggccca aggctgcgga gatgttcgcc     1020

aaggccggca aggctctggt cgtacgcaac gagttgggcg acgcggcaga atacctgcaa     1080

ctggctcacc gggcctccga cgatgtctcc acccgggccg ccttacgggt cgaggccgtg     1140

gcgatcgagc gccgccgcaa tccgctggcc tccagtcggc acatggacga gctgagcgcc     1200

gccggccgcg ccggtctgct ttcccccaag catgcggcgc tggccgtctt ctggctggcc     1260

gacggcgggc gatccggcga ggcagccgag gtgctggcgt cggaacgccc gctagcgacc     1320

accgatcaga accgggccca cttgcgattt gtcgaggtga ctctcgcgct gttctctccc     1380

ggcgccttcg gatcggaccg gcgcccacct ccgctgacgc cggacgaact cgccagcctg     1440

ccgaaggcgg cctggcaatg cgcggtcgcc gacaacgcgg ccatgaccgc cttgcacggt     1500

catccagaac ttgccaccgc tcaggcggaa acagttctgc ggcaggctga ttcggcagcc     1560

gacgcgatcc ccgccgcgct gatcgccctg ttgtacgcgg agaacaccga gtccgctcat     1620

atctgggccg acaagctggg cagcacgaat ggcggggtat cgaacgaggc ggaagcgggc     1680

tacgccggcc cgtgcgccga gatcgccctg cggcgcggcg acctggccac ggcgttcgag     1740

gctggtagca ccgtcctgga cgaccggtcg ctgccgtcgc tcggcatcac cgccgcattg     1800

ctgttgagca gcaagacggc cgccgctgtc cggctgggcg aactcgagcg tgcggagaag     1860

ctgctcgccg agccgcttcc gaacggcgtc caggacagcc ttttcggtct gcacctgctc     1920

tcggcatacg gccagtacag cctcgcgatg ggccgatatg aatcggctct ccgggcgttt     1980

cacacctgcg gagaacgtat gcgcagctgg gatgttgacg tgcctggtct ggccctgtgg     2040

cgtgtcgacg ccgccgaggc gctgctcagc ctcgaccgga acgagggcca gcggctcatc     2100

gacgaacaac tcacccgtcc gatggggcct cgttcccgcg cgttaacgct gcggatcaag     2160

gcggcatacc tcccgcggac gaagcggatc cccctgctcc atgaggcggc cgagctgctg     2220

ctcccctgcc ccgacccgta cgagcaagcg cgggtgctcg ccgatctggg cgacacgctc     2280

agcgcgctca gacgctatag ccgggcgcgg ggagttctcc ggcaggctcg tcacctggcc     2340

gcccagtgcg gtgctgtccc gctgctgcgc aggctcgggg gcgagcccgg ccggatcgac     2400

gacgccggcc tgccgcagcg gagcacatcg ttgaccgatg cggagcggcg ggtggcggcg     2460

ctggccgcgg ccggacagac caaccgggag atcgccaaac agctgttcgt cacggccagc     2520

acagtggaac agcacctcac aagcgtcttc cgcaaactgg gggtcaaggg tcgcaagcag     2580

ctgccgaccg cgctggccga cgtggaacag acctga                               2616


<210>  13
<211>  2721
<212>  DNA
<213>  Streptomyces violaceusniger

<400>  13
atgtatagcg gtacctgccg tgaaggatac gaactcgtcg cacgcgagga cgaactcggc       60

attctacaga ggtctctgga acaagcgagc agcggccagg gcgtcgtggt caccgtcacc      120

ggcccaatcg cctgcggcaa gacagaactg cttgacgcgg ctgccgcgaa ggctgaggcc      180

atcattctgc gcgcggtctg cgcgccagaa gagcgggcta tgccgtacgc catgatcggg      240

cagctcatcg acgacccggc gctcgcgcat cgggcgccgg ggctggctga tcggatagcc      300

cagggcgggc agctgtcgct gagggccgag aaccgactgc gcagggatct cacccgtgcc      360

ctgctggcgc ttgccgtcga ccggcctgtg ctgatcggcg tcgacgatgt gcatcacgcc      420

gacaccgcct ctttgaactg tctgctgcat ttggcgcgcc gggtccgtcc ggcccggata      480

tccatgatct tcaccgagtt gcgcagcctc acccctactc agtcacggtt caaggcggag      540

ctgctcagcc tgccgtacca ccacgagatc gcgctgcgtc cgttcggacc ggagcaatcg      600

gcggagctgg cccgcgccgc cttcggcccg ggcctcgccg aggatgtgct cgtggggttg      660

tataaaacga ccaggggcaa tctgagtctc agccgtggac tgatcagcga tgtgcgggag      720

gccctggcca acggagagag cgccttcgag gcgggccgcg cgttccggct ggcgtacctc      780

ggctcgctct accgctgtgg cccggtcgcg ctgcgggtcg cccgagtggc tgccgtgctg      840

ggcccgagcg ccaccaccac gctggtgcgc cgtctaagcg ggctcagcgc ggagacgata      900

gaccgggcaa ccaagatcct caccgagggc gggctgctgc tcgaccagca gttcccgcac      960

ccggccgccc gctcggtggt gcttgatgac atgtccgccc aggaacgacg cggcctgcac     1020

actctcgccc tggaactgct ggacgaggcg ccggttgaag tgctcgcgca ccaccaggtc     1080

ggcgccggtc tcatacacgg gcccaaggct gcggagatgt tcgccaaggc cggcaaggct     1140

ctggtcgtac gcaacgagtt gggcgacgcg gcagaatacc tgcaactggc tcaccgggcc     1200

tccgacgatg tctccacccg ggccgccctg cgggtcgagg ccgtggcgat cgagcgccgc     1260

cgcaatccgc tggcctccag tcggcacatg gacgagctga gcgccgccgg ccgcgccggt     1320

ctgctttccc ccaagcatgc ggcgctggcc gtcttctggc tggccgacgg cgggcgatcc     1380

ggcgaggcag ccgaggtgct ggcgtcggaa cgcccgctag cgaccaccga tcagaaccgg     1440

gcccacttgc gatttgtcga ggtgactctc gcgctgttct ctcccggcgc cttcggatcg     1500

gaccggcgcc cacctccgct gacgccggac gaactcgcca gcctgccgaa ggcggcctgg     1560

caatgcgcgg tcgccgacaa cgcggccatg accgccttgc acggtcatcc agaacttgcc     1620

accgctcagg cggaaacagt tctgcggcag gctgattcgg cagccgacgc gatccccgcc     1680

gcgctgatcg ccctgttgta cgcggagaac accgagtccg ctcatatctg ggccgacaag     1740

ctgggcagca cgaatggcgg ggtatcgaac gaggcggaag cgggctacgc cggcccgtgc     1800

gccgagatcg ccctgcggcg cggcgacctg gccacggcgt tcgaggctgg tagcaccgtc     1860

ctggacgacc ggtcgctgcc gtcgctcggc atcaccgccg cattgctgtt gagcagcaag     1920

acggccgccg ctgtccggct gggcgaactc gagcgtgcgg agaagctgct cgccgagccg     1980

cttccgaacg gcgtccagga cagccttttc ggtctgcacc tgctctcggc atacggccag     2040

tacagcctcg cgatgggccg atatgaatcg gctctccggg cgtttcacac ctgcggagaa     2100

cgtatgcgca gctgggatgt tgacgtgcct ggtctggccc tgtggcgtgt cgacgccgcc     2160

gaggcgctgc tcagcctcga ccggaacgag ggccagcggc tcatcgacga acaactcacc     2220

cgtccgatgg ggcctcgttc ccgcgcgctg acgctgcgga tcaaggcggc atacctcccg     2280

cggacgaagc ggatccccct gctccatgag gcggccgagc tgctgctccc ctgccccgac     2340

ccgtacgagc aagcgcgggt gctcgccgat ctgggcgaca cgctcagcgc gctcagacgc     2400

tatagccggg cgcggggagt tctccggcag gctcgtcacc tggccgccca gtgcggtgct     2460

gtcccgctgc tgcgcaggct cgggggcgag cccggccgga tcgacgacgc cggcctgccg     2520

cagcggagca catcgttgac cgatgcggag cggcgggtgg cggcgctggc cgcggccgga     2580

cagaccaacc gggagatcgc caaacagctg ttcgtcacgg ccagcacagt ggaacagcac     2640

ctcacaagcg tcttccgcaa actgggggtc aagggtcgca agcagctgcc gaccgcgctg     2700

gccgacgtgg aacagacctg a                                               2721


<210>  14
<211>  2745
<212>  DNA
<213>  Streptomyces hygroscopicus

<400>  14
atgcctgccg tggagagcta tgaactggac gcccgcgatg acgagctcag aagactggag       60

gaggcggtag gccaggcggg caacggccgg ggtgtggtgg tcaccatcac cgggccgatc      120

gcctgcggca agaccgaact gctcgacgcg gccgccgcga agagcgacgc catcacatta      180

cgtgcggtct gctccgagga ggaacgggcc ctcccgtacg ccctgatcgg gcagctcatc      240

gacaacccgg cggtcgcctc ccagctgccg gatccggtct ccatggccct cccgggcgag      300

cacctgtcgc cggaggccga gaaccggctg cgcggcgacc tcacccgtac cctgctggcg      360

ctcgccgccg aacggccggt gctgatcggc atcgacgaca tgcaccacgc cgacaccgcc      420

tctttgaact gcctgctcca cctggcccgg agggtcggcc cggcccggat cgccatggtc      480

ctcaccgagc tgcgccggct caccccggcc cactcccagt tccacgccga gctgctcagc      540

ctggggcacc accgcgagat cgcgctgcgc ccgctcggcc cgaagcacat cgccgagctg      600

gcccgcgccg gcctcggtcc cgatgtcgac gaggacgtgc tcacggggtt gtaccgggcg      660

accggcggca acctgaacct cggccacgga ctgatcaagg atgtgcggga ggcctgggcg      720

acgggcggga cgggcatcaa cgcgggccgc gcgtaccggc tggcgtacct cggttccctc      780

taccgctgcg gcccggtccc gttgcgggtc gcacgggtgg ccgccgtgct gggccagagc      840

gccaacacca ccctggtgcg ctggatcagc gggctcaacg cggacgcggt gggcgaggcg      900

accgagatcc tcaccgaggg cggcctgctg cacgacctgc ggttcccgca tccggcggcc      960

cgttcggtcg tactcaacga cctgtccgcc cgggaacgcc gccgactgca ccggtccgct     1020

ctggaagtgc tggatgacgt acccgttgaa gtggtcgcgc accaccaggc cggtgccggt     1080

ttcatccacg gtcccaaggc cgccgagatc ttcgccaagg ccggccagga gctgcatgtg     1140

cgcggcgagc tggacgccgc gtccgactat ctgcaactgg cccaccacgc ctccgacgac     1200

gccgtcaccc gggccgcgct gcgggtcgag gccgtggcga tcgagcgccg ccgcaacccg     1260

ctggcctcca gccgccacct cgacgagctg accgtcgccg cccgtgccgg tctgctctcc     1320

ctcgagcacg ccgcgctgat gatccgctgg ctggctctcg gcgggcggtc cggcgaggcg     1380

gccgaggtgc tggccgcgca gcgcccgcgt gcggtcaccg accaggacag ggcccacctg     1440

cgggccgccg aggtatcgct ggcgctggtc agcccgggcg cgtccggcgt cagcccgggt     1500

gcgtccggcc cggatcggcg gccgcgtccg ctcccgccgg atgagctcgc gaacctgccg     1560

aaggcggccc ggctttgtgc gatcgccgac aacgccgtca tatcggccct gcacggtcgt     1620

cccgagcttg cctcggccga ggcggagaac gtcctgaagc aggctgactc ggcggcggac     1680

ggcgccaccg ccctctccgc gctgacggcc ttgctgtacg cggagaacac cgacaccgct     1740

cagctctggg ccgacaagct cgtctccgag accggggcgt cgaacgagga ggaaggcgcg     1800

ggctacgcgg ggccgcgcgc cgagaccgcg ttgcgccgcg gcgacctggc cgcggcggtc     1860

gaggcgggca gcgccattct ggaccaccgg cgggggtcgt tgctcggcat caccgccgcg     1920

ctaccgctga gcagcgcggt agccgccgcc atccggctgg gcgagaccga gcgggcggag     1980

aagtggctcg ccgagccgct gccggaggcc attcgggaca gcctgttcgg gctgcacctg     2040

ctctcggcgc gcggccagta ctgcctcgcg acgggccggc acgagtcggc gtacacggcg     2100

ttccgcacct gcggggaacg gatgcggaac tggggcgtcg acgtgccggg tctgtccctg     2160

tggcgcgtcg acgccgccga ggcgctgctg cacggccgcg accgggacga gggccgacgg     2220

ctcatcgacg agcagctcac ccatgcgatg ggaccccgtt cccgcgcttt gacgctgcgg     2280

gtgcaggcgg cgtacagccc gcaggcgcag cgggtcgacc tgctcgaaga ggcggccgac     2340

ctgctgctct cctgcaacga ccagtacgag cgggcgcggg tgctcgccga tctgagcgag     2400

gcgttcagcg cgctcaggca ccacagccgg gcgcggggac tgctccggca ggcccggcac     2460

ctggccgccc agtgcggcgc gaccccgctg ctgcgccggc tcggggccaa gcccggaggc     2520

cccggctggc tggaggaatc cggcctgccg cagcggatca agtcgctgac cgacgcggag     2580

cggcgggtgg cgtcgctggc cgccggcggc cagaccaacc gcgtgatcgc cgaccagctc     2640

ttcgtcacgg ccagcacggt ggagcagcac ctcacgaacg tcttccgcaa gctgggcgtc     2700

aagggccgcc agcacctgcc ggccgaactc gccaacgcgg aatag                     2745


<210>  15
<211>  2745
<212>  DNA
<213>  Streptomyces hygroscopicus

<400>  15
atgcctgccg tggagagcta tgaactggac gcccgcgatg acgagctcag aagactggag       60

gaggcggtag gccaggcggg caacggccgg ggtgtggtgg tcaccatcac cgggccgatc      120

gcctgcggca agaccgaact gctcgacgcg gccgccgcga agagcgacgc catcacactg      180

cgtgcggtct gctccgagga ggaacgggcc ctcccgtacg ccctgatcgg gcagctcatc      240

gacaacccgg cggtcgcctc ccagctgccg gatccggtct ccatggccct cccgggcgag      300

cacctgtcgc cggaggccga gaaccggctg cgcggcgacc tcacccgtac cctgctggcg      360

ctcgccgccg aacggccggt gctgatcggc atcgacgaca tgcaccacgc cgacaccgcc      420

tctttgaact gcctgctcca cctggcccgg agggtcggcc cggcccggat cgccatggtc      480

ctcaccgagc tgcgccggct caccccggcc cactcccagt tccacgccga gctgctcagc      540

ctggggcacc accgcgagat cgcgctgcgc ccgctcggcc cgaagcacat cgccgagctg      600

gcccgcgccg gcctcggtcc cgatgtcgac gaggacgtgc tcacggggtt gtaccgggcg      660

accggcggca acctgaacct cggccacgga ctgatcaagg atgtgcggga ggcctgggcg      720

acgggcggga cgggcatcaa cgcgggccgc gcgtaccggc tggcgtacct cggttccctc      780

taccgctgcg gcccggtccc gttgcgggtc gcacgggtgg ccgccgtgct gggccagagc      840

gccaacacca ccctggtgcg ctggatcagc gggctcaacg cggacgcggt gggcgaggcg      900

accgagatcc tcaccgaggg cggcctgctg cacgacctgc ggttcccgca tccggcggcc      960

cgttcggtcg tactcaacga cctgtccgcc cgggaacgcc gccgactgca ccggtccgct     1020

ctggaagtgc tggatgacgt acccgttgaa gtggtcgcgc accaccaggc cggtgccggt     1080

ttcatccacg gtcccaaggc cgccgagatc ttcgccaagg ccggccagga gctgcatgtg     1140

cgcggcgagc tggacgccgc gtccgactat ctgcaactgg cccaccacgc ctccgacgac     1200

gccgtcaccc gggccgcgct gcgggtcgag gccgtggcga tcgagcgccg ccgcaacccg     1260

ctggcctcca gccgccacct cgacgagctg accgtcgccg cccgtgccgg tctgctctcc     1320

ctcgagcacg ccgcgctgat gatccgctgg ctggctctcg gcgggcggtc cggcgaggcg     1380

gccgaggtgc tggccgcgca gcgcccgcgt gcggtcaccg accaggacag ggcccacctg     1440

cgggccgccg aggtatcgct ggcgctggtc agcccgggcg cgtccggcgt cagcccgggt     1500

gcgtccggcc cggatcggcg gccgcgtccg ctcccgccgg atgagctcgc gaacctgccg     1560

aaggcggccc ggctttgtgc gatcgccgac aacgccgtca tatcggccct gcacggtcgt     1620

cccgagcttg cctcggccga ggcggagaac gtcctgaagc aggctgactc ggcggcggac     1680

ggcgccaccg ccctctccgc gctgacggcc ttgctgtacg cggagaacac cgacaccgct     1740

cagctctggg ccgacaagct cgtctccgag accggggcgt cgaacgagga ggaaggcgcg     1800

ggctacgcgg ggccgcgcgc cgagaccgcg ttgcgccgcg gcgacctggc cgcggcggtc     1860

gaggcgggca gcgccattct ggaccaccgg cgggggtcgt tgctcggcat caccgccgcg     1920

ctaccgctga gcagcgcggt agccgccgcc atccggctgg gcgagaccga gcgggcggag     1980

aagtggctcg ccgagccgct gccggaggcc attcgggaca gcctgttcgg gctgcacctg     2040

ctctcggcgc gcggccagta ctgcctcgcg acgggccggc acgagtcggc gtacacggcg     2100

ttccgcacct gcggggaacg gatgcggaac tggggcgtcg acgtgccggg tctgtccctg     2160

tggcgcgtcg acgccgccga ggcgctgctg cacggccgcg accgggacga gggccgacgg     2220

ctcatcgacg agcagctcac ccatgcgatg ggaccccgtt cccgcgcttt gacgctgcgg     2280

gtgcaggcgg cgtacagccc gcaggcgcag cgggtcgacc tgctcgaaga ggcggccgac     2340

ctgctgctct cctgcaacga ccagtacgag cgggcgcggg tgctcgccga tctgagcgag     2400

gcgttcagcg cgctcaggca ccacagccgg gcgcggggac tgctccggca ggcccggcac     2460

ctggccgccc agtgcggcgc gaccccgctg ctgcgccggc tcggggccaa gcccggaggc     2520

cccggctggc tggaggaatc cggcctgccg cagcggatca agtcgctgac cgacgcggag     2580

cggcgggtgg cgtcgctggc cgccggcggc cagaccaacc gcgtgatcgc cgaccagctc     2640

ttcgtcacgg ccagcacggt ggagcagcac ctcacgaacg tcttccgcaa gctgggcgtc     2700

aagggccgcc agcacctgcc ggccgaactc gccaacgcgg aatag                     2745


<210>  16
<211>  2619
<212>  DNA
<213>  Actinoplanes sp. N01-109

<400>  16
gtgaagcgca acgatctggt tgcccgcgat ggcgagctca ggtggatgca agagattctc       60

agtcaggcga gcgagggccg gggggccgtg gtcaccatca cgggggcgat cgcctgtggc      120

aagacggtgc tgctggacgc cgcggcagcc agtcaagacg tgatccaact gcgtgcggtc      180

tgctcggcgg aggagcagga gctgccgtac gcgatggtcg gacaactact cgacaatccg      240

gtgctcgccg cgcgagtgcc ggccctgggc aacctggctg cggcgggcga gcggctgctg      300

ccgggcaccg agaacaggat ccggcgggag ctcacccgca ccctgctggc tctcgccgac      360

gaacgaccgg tgctgatcgg cgtcgacgac atgcaccatg cggaccccgc ctcgctggac      420

tgcctgctgc acctggcccg gcgggtcggc ccggcccgca tcgcgatcgt tctgaccgag      480

ttgcgccggc tcaccccggc tcactcgcgc ttccagtccg agctgctcag cctgcggtac      540

caccacgaga tcgggttgca gccgctcacc gcggagcaca ccgccgacct ggcccgcgtc      600

ggcctcggtg ccgaggtcga cgacgacgtg ctcaccgagc tctacgaggc gaccggcggc      660

aacccgagtc tgtgctgcgg cctgatcagg gacgtgcggc aggactggga ggccggggtc      720

accggtatcc acgtcggccg ggcgtaccgg ctggcctatc tcagttcgct ctaccgctgc      780

ggcccggcgg cgctgcggac cgcccgcgcg gccgcggtgc tgggcgacag cgccgacgcc      840

tgcctgatcc gccgggtcag cggcctcggt acggaggccg tgggccaggc gatccagcag      900

ctcaccgagg gcggcctgct gcgtgaccag cagttcccgc acccggcggc ccgctcggtc      960

gtgctcgacg acatgtccgc gcaggaacgc cacgcgatgt atcgcagcgc ccgggaggca     1020

gccgccgaag gtcaggccga ccccggcacc ccgggcgagc cgcgggcggc tacggcgtac     1080

gccgggtgtg gtgagcaagc cggtgactac ccggagccgg ccggccgggc ctgcgtggac     1140

ggtgccggtc cggccgagta ctgcggcgac ccgcacggcg ccgacgacga cccggacgag     1200

ctggtcgccg cgctgggcgg gctgctgccg agccggctcg tggcgatgaa gatccggcgc     1260

ctggcggtgg ccgggcgccc cggggcggct gccgagctgc tgacctcgca gcggttgcac     1320

gcggtgacca gcgaggaccg ggccagcctg cgggccgccg aggtggcgct cgccacgctg     1380

tggccgggtg cgaccggccc ggaccggcat ccgctcacgg agcaggaggc ggcgagcctg     1440

ccggagggtc cgcgcctgct cgctgccgcc gacgatgccg tcggggccgc cctgcgcggt     1500

cgcgccgagt acgccgcggc cgaggcggag aacgtcctgc ggcacgccga tccggcagcc     1560

ggtggtgacg cctacgccgc catgatcgcc ctgctgtaca cggagcaccc cgagaacgtg     1620

ctgttctggg ccgacaagct cgacgcgggc cgccccgacg aggagaccag ttatcccggg     1680

ctgcgggccg agaccgcggt gcggctcggt gacctggaaa cggcgatgga gctgggccgc     1740

acggtgctgg accagcggcg gctgccgtcc ctgggtgtcg ccgcgggcct gctcctgggc     1800

ggcgcggtga cggccgccat ccggctcggc gacctcgacc gggcggagaa gtggctcgcc     1860

gagccgatcc ccgacgccat ccgtaccagc ctctacggcc tgcacgtgct ggccgcgcgg     1920

ggccggctcg acctggccgc gggccgctac gaggcggcgt acacggcgtt ccggctgtgt     1980

ggcgagcgga tggcaggctg ggatgccgat gtctccgggc tggcgctgtg gcgcgtcgac     2040

gccgccgagg ccctgctgtc cgcgggcatc cgcccggacg agggccgcaa gctcatcgac     2100

gaccagctca cccgtgagat gggggcccgc tcccgggcgc tgacgctgcg ggcgcaagcg     2160

gcgtacagcc tgccggtgca ccgggtgggc ctgctcgacg aggcggccgg cctgctgctc     2220

gcctgccatg acgggtacga gcgggcgcgg gtgctcgcgg acctggggga gaccctgcgc     2280

acgctgcggc acaccgacgc ggcccagcgg gtgctccggc aggccgagca ggcggccgcg     2340

cggtgcgggt cggtcccgct gctgcggcgg ctcggggccg aacccgtacg catcggcacc     2400

cggcgtggtg aacccggcct gccgcagcgg atcaggctgc tgaccgatgc cgagcggcgg     2460

gttgccgcga tggccgccgc cgggcagacc aaccgggaga tcgccggtcg gctcttcgtc     2520

acggccagca cggtggagca gcacctgacc agcgtcttcc gcaagctggg cgtcaagggc     2580

cgccggttcc tgccgaccga gctcgcccaa gccgtctga                            2619


<210>  17
<211>  2628
<212>  DNA
<213>  Actinoplanes sp. N01-109

<400>  17
atgcctgccg tgaagcgcaa cgatctggtt gcccgcgatg gcgagctcag gtggatgcaa       60

gagattctca gtcaggcgag cgagggccgg ggggccgtgg tcaccatcac gggggcgatc      120

gcctgtggca agacggtgct gctggacgcc gcggcagcca gtcaagacgt gatccaactg      180

cgtgcggtct gctcggcgga ggagcaggag ctgccgtacg cgatggtcgg acaactactc      240

gacaatccgg tgctcgccgc gcgagtgccg gccctgggca acctggctgc ggcgggcgag      300

cggctgctgc cgggcaccga gaacaggatc cggcgggagc tcacccgcac cctgctggct      360

ctcgccgacg aacgaccggt gctgatcggc gtcgacgaca tgcaccatgc ggaccccgcc      420

tcgctggact gcctgctgca cctggcccgg cgggtcggcc cggcccgcat cgcgatcgtt      480

ctgaccgagt tgcgccggct caccccggct cactcgcgct tccagtccga gctgctcagc      540

ctgcggtacc accacgagat cgggttgcag ccgctcaccg cggagcacac cgccgacctg      600

gcccgcgtcg gcctcggtgc cgaggtcgac gacgacgtgc tcaccgagct ctacgaggcg      660

accggcggca acccgagtct gtgctgcggc ctgatcaggg acgtgcggca ggactgggag      720

gccggggtca ccggtatcca cgtcggccgg gcgtaccggc tggcctatct cagttcgctc      780

taccgctgcg gcccggcggc gctgcggacc gcccgcgcgg ccgcggtgct gggcgacagc      840

gccgacgcct gcctgatccg ccgggtcagc ggcctcggta cggaggccgt gggccaggcg      900

atccagcagc tcaccgaggg cggcctgctg cgtgaccagc agttcccgca cccggcggcc      960

cgctcggtcg tgctcgacga catgtccgcg caggaacgcc acgcgatgta tcgcagcgcc     1020

cgggaggcag ccgccgaagg tcaggccgac cccggcaccc cgggcgagcc gcgggcggct     1080

acggcgtacg ccgggtgtgg tgagcaagcc ggtgactacc cggagccggc cggccgggcc     1140

tgcgtggacg gtgccggtcc ggccgagtac tgcggcgacc cgcacggcgc cgacgacgac     1200

ccggacgagc tggtcgccgc gctgggcggg ctgctgccga gccggctcgt ggcgatgaag     1260

atccggcgcc tggcggtggc cgggcgcccc ggggcggctg ccgagctgct gacctcgcag     1320

cggttgcacg cggtgaccag cgaggaccgg gccagcctgc gggccgccga ggtggcgctc     1380

gccacgctgt ggccgggtgc gaccggcccg gaccggcatc cgctcacgga gcaggaggcg     1440

gcgagcctgc cggagggtcc gcgcctgctc gctgccgccg acgatgccgt cggggccgcc     1500

ctgcgcggtc gcgccgagta cgccgcggcc gaggcggaga acgtcctgcg gcacgccgat     1560

ccggcagccg gtggtgacgc ctacgccgcc atgatcgccc tgctgtacac ggagcacccc     1620

gagaacgtgc tgttctgggc cgacaagctc gacgcgggcc gccccgacga ggagaccagt     1680

tatcccgggc tgcgggccga gaccgcggtg cggctcggtg acctggaaac ggcgatggag     1740

ctgggccgca cggtgctgga ccagcggcgg ctgccgtccc tgggtgtcgc cgcgggcctg     1800

ctcctgggcg gcgcggtgac ggccgccatc cggctcggcg acctcgaccg ggcggagaag     1860

tggctcgccg agccgatccc cgacgccatc cgtaccagcc tctacggcct gcacgtgctg     1920

gccgcgcggg gccggctcga cctggccgcg ggccgctacg aggcggcgta cacggcgttc     1980

cggctgtgtg gcgagcggat ggcaggctgg gatgccgatg tctccgggct ggcgctgtgg     2040

cgcgtcgacg ccgccgaggc cctgctgtcc gcgggcatcc gcccggacga gggccgcaag     2100

ctcatcgacg accagctcac ccgtgagatg ggggcccgct cccgggcgct gacgctgcgg     2160

gcgcaagcgg cgtacagcct gccggtgcac cgggtgggcc tgctcgacga ggcggccggc     2220

ctgctgctcg cctgccatga cgggtacgag cgggcgcggg tgctcgcgga cctgggggag     2280

accctgcgca cgctgcggca caccgacgcg gcccagcggg tgctccggca ggccgagcag     2340

gcggccgcgc ggtgcgggtc ggtcccgctg ctgcggcggc tcggggccga acccgtacgc     2400

atcggcaccc ggcgtggtga acccggcctg ccgcagcgga tcaggctgct gaccgatgcc     2460

gagcggcggg ttgccgcgat ggccgccgcc gggcagacca accgggagat cgccggtcgg     2520

ctcttcgtca cggccagcac ggtggagcag cacctgacca gcgtcttccg caagctgggc     2580

gtcaagggcc gccggttcct gccgaccgag ctcgcccaag ccgtctga                  2628


<210>  18
<211>  2616
<212>  DNA
<213>  Streptomyces malaysiensis

<400>  18
gtggtcaccg tcaccggccc aatcgcctgc ggcaagacag aactgcttga cgcggctgcc       60

gcgaaggctg aggccatcat tctgcgcgcg gtctgcgcgc cagaagagcg ggctatgccg      120

tacgccatga tcgggcagct catcgacgac ccggcgctcg cgcatcgggc gccggggctg      180

gctgatcgga tagcccaggg cgggcagctg tcgctgaggg ccgagaaccg actgcgcagg      240

gatctcaccc gtgccctgct ggcgcttgcc gtggaccggc ctgtgctgat cggcgtcgac      300

gatgtgcatc acgccgacac cgcctctttg aactgtctgc tgcatttggc ccgccgggtc      360

cgtccggccc ggatatccat gatcttcacc gagttgcgca gcctcacccc tactcagtca      420

cggttcaagg cggagctgct cagcctgcca taccaccacg agatcgcgct gcgtccattc      480

ggaccggagc aatcggcgga gctggctcgc gccgccttcg gcccgggcct cgccgaggat      540

gtgctcgcgg ggttgtataa aacgaccagg ggcaatctga gtctcagccg tggactgatc      600

agcgatgtgc gggaggccct ggccaacgga gagagcgctt tcgaggcggg ccgcgcgttc      660

cggctggcgt acctcagctc gctctaccgc tgtggcccgg tcgcgctgcg ggtcgcccga      720

gtggctgccg tgctgggccc aagcgccacc accacgctgg tgcgccggct aagcgggctc      780

agcgcggaga cgatagaccg ggcaaccaag atcctcactg agggcgggct gctgctcgac      840

cagcagttcc cgcacccggc cgcccgctcg gtggtgctcg atgacatgtc cgcccaggaa      900

cgacgcagcc tgcacactct cgccctggaa ctgctggacg aggcgccggt tgaagtgctc      960

gcgcaccacc aggtcggcgc cggtctcata cacgggccca aggctgcgga gatgttcgcc     1020

aaggccggca aggctctggt cgtacgcaac gagttgggcg acgcggccga atacctgcaa     1080

ctggctcacc gggcctccga cgatgtctcc acccgggccg ccttacgggt cgaggccgtg     1140

gccatcgagc gccgccgcaa tccgctggcc tccagtcggc acatggacga actgagcgcc     1200

gccggccgcg ccggtctgct ttcccccaag catgcggcgc tggccgtctt ctggctagcc     1260

gacggcgggc gatccggcga ggcagccgaa gtgctggcgt cggaacgccc gctcgcgacc     1320

accgatcaga accgggccca cctgcgattt gtcgaggtga ctctcgcgct gttctctccc     1380

ggcgccttcg gatcggaccg gcgcccacct ccgctgacgc cggacgaact cgccagcctg     1440

ccgaaggcgg cctggcaatg cgcggtcgcc gacaacgcgg ccatgaccgc cttgcacggc     1500

catccagaac ttgccaccgc tcaggcggaa acagttctgc ggcaggctga ttcggcagcc     1560

gacgcgatcc ccgccgcgct gatcgccctg ttgtacgcgg agaacaccga gtccgctcat     1620

atctgggccg acaagctggg cagcacgaat gccggggtat cgaacgaggc ggaagcgggc     1680

tacgccggcc cgtgcgccga gatcgccctg cggcgcggcg acctggccac ggcgttcgag     1740

gctggtagcg ccgtcctgga cgaccggtcg ctgccgtcgc tcggcatcac cgccgcattg     1800

ctgttgagca gcaagacggc cgccgctgtc cggctgggcg aactcgagcg tgcggagaag     1860

ctgctcgccg agccgcttcc gaacggcgtc caggacagcc ttttcggtct gcacctgctc     1920

tcggcgtacg gccagtacag cctcgcgatg ggccgatatg aatcagctca ccgggcgttt     1980

cgcacctgcg gagaacgtat gcgcagctgg gatgttgacg tgcctggtct ggccctgtgg     2040

cgtgtcgacg ccgccgaggc gctgctcagc ctcgaccgga acgagggcca gcggctcatc     2100

gacgaacaac tcacccgtcc gatggggcct cgttcccacg cgttaacgct gcggatcaag     2160

gcggcatacc tcccgcggac gaagcggatc cccctgctcc atgaggcggc cgagctgctg     2220

ctcccctgcc ccgacccgta cgagcaagcg cgggtgctcg ccgatctggg cgacacgctc     2280

agcgcgctca gacgctatag ccgggcgcgg ggagttctcc ggcaggctcg tcacctggcc     2340

acccagtgcg gtgctgtccc gctgctgcgc aggctcgggg gcgagcccgg ccggatcgac     2400

gacgccggcc tgccgcagcg gagcacatcg ttgaccgatg cggagcggcg ggtggcggcg     2460

ctggccgcgg ccggacagac caaccgggag atcgccgaac agctgttcgt cacggccagc     2520

acagtggaac agcacctcac aagcgtcttc cgcaagctgg gcgtcaaggg ccgcaagcag     2580

ctgccgaccg cgctggccga cgtggaacag acctga                               2616


<210>  19
<211>  2721
<212>  DNA
<213>  Streptomyces malaysiensis

<400>  19
atgtatagcg gtacctgccg tgaaggatac gaactcgtcg cacgcgagga cgaactcggt       60

attctacaga ggtctctgga acaagcgagc agcggccagg gcgtcgtggt caccgtcacc      120

ggcccaatcg cctgcggcaa gacagaactg cttgacgcgg ctgccgcgaa ggctgaggcc      180

atcattctgc gcgcggtctg cgcgccagaa gagcgggcta tgccgtacgc catgatcggg      240

cagctcatcg acgacccggc gctcgcgcat cgggcgccgg ggctggctga tcggatagcc      300

cagggcgggc agctgtcgct gagggccgag aaccgactgc gcagggatct cacccgtgcc      360

ctgctggcgc ttgccgtgga ccggcctgtg ctgatcggcg tcgacgatgt gcatcacgcc      420

gacaccgcct ctttgaactg tctgctgcat ttggcccgcc gggtccgtcc ggcccggata      480

tccatgatct tcaccgagtt gcgcagcctc acccctactc agtcacggtt caaggcggag      540

ctgctcagcc tgccatacca ccacgagatc gcgctgcgtc cattcggacc ggagcaatcg      600

gcggagctgg ctcgcgccgc cttcggcccg ggcctcgccg aggatgtgct cgcggggttg      660

tataaaacga ccaggggcaa tctgagtctc agccgtggac tgatcagcga tgtgcgggag      720

gccctggcca acggagagag cgctttcgag gcgggccgcg cgttccggct ggcgtacctc      780

agctcgctct accgctgtgg cccggtcgcg ctgcgggtcg cccgagtggc tgccgtgctg      840

ggcccaagcg ccaccaccac gctggtgcgc cggctaagcg ggctcagcgc ggagacgata      900

gaccgggcaa ccaagatcct cactgagggc gggctgctgc tcgaccagca gttcccgcac      960

ccggccgccc gctcggtggt gctcgatgac atgtccgccc aggaacgacg cagcctgcac     1020

actctcgccc tggaactgct ggacgaggcg ccggttgaag tgctcgcgca ccaccaggtc     1080

ggcgccggtc tcatacacgg gcccaaggct gcggagatgt tcgccaaggc cggcaaggct     1140

ctggtcgtac gcaacgagtt gggcgacgcg gccgaatacc tgcaactggc tcaccgggcc     1200

tccgacgatg tctccacccg ggccgccctg cgggtcgagg ccgtggccat cgagcgccgc     1260

cgcaatccgc tggcctccag tcggcacatg gacgaactga gcgccgccgg ccgcgccggt     1320

ctgctttccc ccaagcatgc ggcgctggcc gtcttctggc tagccgacgg cgggcgatcc     1380

ggcgaggcag ccgaagtgct ggcgtcggaa cgcccgctcg cgaccaccga tcagaaccgg     1440

gcccacctgc gatttgtcga ggtgactctc gcgctgttct ctcccggcgc cttcggatcg     1500

gaccggcgcc cacctccgct gacgccggac gaactcgcca gcctgccgaa ggcggcctgg     1560

caatgcgcgg tcgccgacaa cgcggccatg accgccttgc acggccatcc agaacttgcc     1620

accgctcagg cggaaacagt tctgcggcag gctgattcgg cagccgacgc gatccccgcc     1680

gcgctgatcg ccctgttgta cgcggagaac accgagtccg ctcatatctg ggccgacaag     1740

ctgggcagca cgaatgccgg ggtatcgaac gaggcggaag cgggctacgc cggcccgtgc     1800

gccgagatcg ccctgcggcg cggcgacctg gccacggcgt tcgaggctgg tagcgccgtc     1860

ctggacgacc ggtcgctgcc gtcgctcggc atcaccgccg cattgctgtt gagcagcaag     1920

acggccgccg ctgtccggct gggcgaactc gagcgtgcgg agaagctgct cgccgagccg     1980

cttccgaacg gcgtccagga cagccttttc ggtctgcacc tgctctcggc gtacggccag     2040

tacagcctcg cgatgggccg atatgaatca gctcaccggg cgtttcgcac ctgcggagaa     2100

cgtatgcgca gctgggatgt tgacgtgcct ggtctggccc tgtggcgtgt cgacgccgcc     2160

gaggcgctgc tcagcctcga ccggaacgag ggccagcggc tcatcgacga acaactcacc     2220

cgtccgatgg ggcctcgttc ccacgcgctg acgctgcgga tcaaggcggc atacctcccg     2280

cggacgaagc ggatccccct gctccatgag gcggccgagc tgctgctccc ctgccccgac     2340

ccgtacgagc aagcgcgggt gctcgccgat ctgggcgaca cgctcagcgc gctcagacgc     2400

tatagccggg cgcggggagt tctccggcag gctcgtcacc tggccaccca gtgcggtgct     2460

gtcccgctgc tgcgcaggct cgggggcgag cccggccgga tcgacgacgc cggcctgccg     2520

cagcggagca catcgttgac cgatgcggag cggcgggtgg cggcgctggc cgcggccgga     2580

cagaccaacc gggagatcgc cgaacagctg ttcgtcacgg ccagcacagt ggaacagcac     2640

ctcacaagcg tcttccgcaa gctgggcgtc aagggccgca agcagctgcc gaccgcgctg     2700

gccgacgtgg aacagacctg a                                               2721


<210>  20
<211>  2715
<212>  DNA
<213>  Streptomyces violaceusniger

<400>  20
gtgtatagcg gtacctgccg tgaaggatac gaactcgtcg cccgcgagga cgaactcggc       60

attctgcaga ggtctctgga agaagcaggc agcggccagg gcgccgtggt caccgtcacc      120

ggcccgatcg cctgcggcaa gacagaactg cttgacgcgg ctgccgcgaa ggctgacgcc      180

atcattctgc gcgcggtctg cgcgcccgaa gagcgcgcta tgccgtacgc catgatcggg      240

cagctcatcg acgacccggc gctcgcgcat cgggcgccgg agctggctga tcggatagcc      300

cagggcgggc atctgtcgct gagggccgag aaccgactgc gcagggatct cacccgtgcc      360

ctgctggcgc ttgccgtcga ccggcctgtg ctgatcggcg tcgacgatgt gcatcacgcc      420

gacaccgcct ctttgaactg tctgctgcat ttagcccgcc gggtccgtcc ggcccggata      480

tccatgatct tcaccgagtt gcgcagcctc acccctactc agtcacgatt caaggcggag      540

ctgctcagcc tgccgtacca ccacgagatc gcgctgcgtc cactcggacc ggagcaatcg      600

gcggagctgg cccacgccgc cttcggcccg ggcctcgccg aggatgtgct cgcggggttg      660

tatgggatga ccaggggcaa cctgagtctc agccgtggac tgatcagcga tgtgcgggag      720

gcccaggcca acggagagag cgctttcgag gtgggccgcg cgttccggct ggcgtacctc      780

agctcgctct accgctgtgg cccgatcgcg ctgcgggtcg cccgagtggc tgccgtgctg      840

ggcccaagcg ccaccaccac gctggtgcgc cgtctaagcg ggctcagcgc ggagacgata      900

gaccgggcaa ccaagatcct cactgagggc gggctgctgc tcgaccacca gttcccgcac      960

ccggccgccc gctcggtggt gctcgatgac atgtccgccc aggaacgacg cagcctgcac     1020

actctcgccc tggaactgct ggacgaggcg ccggttgaag tgctcgcgca ccaccaggtc     1080

ggcgccggtc tcatacacgg gcccaaggct gcggagatat tcgccagggc tggccaggct     1140

ctggttgtac gcaacgagtt gggcgacgcg gccgaatacc tgcaactggc tcaccgagcc     1200

tccgacgatg tctccacccg ggccgcctta cgggtcgagg ccgtggcaat cgagcgccgc     1260

cgcaatccgc tggcctccag tcgtcacatg gacgagctga gcgccgccgg ccgcgccggt     1320

ctgctttccc ccaagcatgc agcgctggct gtcttctggc tggccgacgg cgggcgatcc     1380

ggcgaggcag ccgaggtgct ggcgtcggaa cacccgctcg cgaccaccga tcagaaccga     1440

gcacacctgc gatttgccga ggtgactctc gcgctgttct gtcccggcgc cttcgggtcg     1500

gaccggcgcc cacctccgct ggcgccggac gagctcgcca gcttgccgaa ggcggcctgg     1560

caatgcgcgg tcgccgacaa cgcggtcatg acagcgttgc atgctcatcc agaacttgcc     1620

accgctcagg cggaaacagt tctgcggcag gctgattcgg cagccgacgc aatccccgcc     1680

gcactgatcg ccctgttgta cgcagagaac accgagtccg ctcagatctg ggccgacaag     1740

ctgggcagca ccaatgccgg ggtatcgaac gaggcggaag cgggctacgc cggcccgtgc     1800

gccgagatcg ccctgcggcg cggcgacctg gccacggcgt tcgaggctgg tggcaccgtc     1860

ctggacgacc ggccgctgcc gtcgctcggc atcaccgccg cattgctgtt gagcagcaag     1920

acggcagccg ctgtccgcct gggcgaactc gagcgtgcgg agaagctgct cgctgagccg     1980

cttccgaacg gtgtccagga cagccttttc ggtctgcacc tgctctcggc gcacggccag     2040

tacagcctcg cgatgggccg atatgaatcg gctcaccggg cgtttcacac ctgcggagaa     2100

cgtatgcgca gctggggtgt tgacgtgcct ggtctagccc tgtggcgtgt cgacgccgcc     2160

gaggcactgc tcagcctcga ccggaacgag ggccagcggc tcatcgacga acaactcgcc     2220

cgtccgatgg gacctcgttc ccgcgcatta acgctgcgga tcaaggcggc atacctcccg     2280

cggacgaagc ggatccccct gctccatgag gcagctgagc tgctgctctc ctgccccgac     2340

ccgtacgagc aagcgcgggt gctcgccgat ctgggcgaca cgctcagcgc gctcagacgc     2400

tatagccggg cgcggggagt tctccggcag gctcgtcacc tggccaccca gtgcggtgct     2460

gtcccgctgc tgcgccgact cgggggcgag cccggccgga tcgacgacgc cggcctgccg     2520

cagcggagca catcgttgac cgatgcggag cggcgggtgt cggccctggc cgcggccgga     2580

cagaccaacc gggagatcgc caaacagcta ttcgtcacgg ccagcaccgt ggaacagcac     2640

ctcacaagcg tcttccgcaa gctgggcgtt aagggccgca ggcagctacc gaccgcgctg     2700

gccgacgtgg aatag                                                      2715


<210>  21
<211>  2715
<212>  DNA
<213>  Streptomyces violaceusniger

<400>  21
atgtatagcg gtacctgccg tgaaggatac gaactcgtcg cccgcgagga cgaactcggc       60

attctgcaga ggtctctgga agaagcaggc agcggccagg gcgccgtggt caccgtcacc      120

ggcccgatcg cctgcggcaa gacagaactg cttgacgcgg ctgccgcgaa ggctgacgcc      180

atcattctgc gcgcggtctg cgcgcccgaa gagcgcgcta tgccgtacgc catgatcggg      240

cagctcatcg acgacccggc gctcgcgcat cgggcgccgg agctggctga tcggatagcc      300

cagggcgggc atctgtcgct gagggccgag aaccgactgc gcagggatct cacccgtgcc      360

ctgctggcgc ttgccgtcga ccggcctgtg ctgatcggcg tcgacgatgt gcatcacgcc      420

gacaccgcct ctttgaactg tctgctgcat ctggcccgcc gggtccgtcc ggcccggata      480

tccatgatct tcaccgagtt gcgcagcctc acccctactc agtcacgatt caaggcggag      540

ctgctcagcc tgccgtacca ccacgagatc gcgctgcgtc cactcggacc ggagcaatcg      600

gcggagctgg cccacgccgc cttcggcccg ggcctcgccg aggatgtgct cgcggggttg      660

tatgggatga ccaggggcaa cctgagtctc agccgtggac tgatcagcga tgtgcgggag      720

gcccaggcca acggagagag cgctttcgag gtgggccgcg cgttccggct ggcgtacctc      780

agctcgctct accgctgtgg cccgatcgcg ctgcgggtcg cccgagtggc tgccgtgctg      840

ggcccaagcg ccaccaccac gctggtgcgc cgtctaagcg ggctcagcgc ggagacgata      900

gaccgggcaa ccaagatcct cactgagggc gggctgctgc tcgaccacca gttcccgcac      960

ccggccgccc gctcggtggt gctcgatgac atgtccgccc aggaacgacg cagcctgcac     1020

actctcgccc tggaactgct ggacgaggcg ccggttgaag tgctcgcgca ccaccaggtc     1080

ggcgccggtc tcatacacgg gcccaaggct gcggagatat tcgccagggc tggccaggct     1140

ctggttgtac gcaacgagtt gggcgacgcg gccgaatacc tgcaactggc tcaccgagcc     1200

tccgacgatg tctccacccg ggccgccctg cgggtcgagg ccgtggcaat cgagcgccgc     1260

cgcaatccgc tggcctccag tcgtcacatg gacgagctga gcgccgccgg ccgcgccggt     1320

ctgctttccc ccaagcatgc agcgctggct gtcttctggc tggccgacgg cgggcgatcc     1380

ggcgaggcag ccgaggtgct ggcgtcggaa cacccgctcg cgaccaccga tcagaaccga     1440

gcacacctgc gatttgccga ggtgactctc gcgctgttct gtcccggcgc cttcgggtcg     1500

gaccggcgcc cacctccgct ggcgccggac gagctcgcca gcttgccgaa ggcggcctgg     1560

caatgcgcgg tcgccgacaa cgcggtcatg acagcgttgc atgctcatcc agaacttgcc     1620

accgctcagg cggaaacagt tctgcggcag gctgattcgg cagccgacgc aatccccgcc     1680

gcactgatcg ccctgttgta cgcagagaac accgagtccg ctcagatctg ggccgacaag     1740

ctgggcagca ccaatgccgg ggtatcgaac gaggcggaag cgggctacgc cggcccgtgc     1800

gccgagatcg ccctgcggcg cggcgacctg gccacggcgt tcgaggctgg tggcaccgtc     1860

ctggacgacc ggccgctgcc gtcgctcggc atcaccgccg cattgctgtt gagcagcaag     1920

acggcagccg ctgtccgcct gggcgaactc gagcgtgcgg agaagctgct cgctgagccg     1980

cttccgaacg gtgtccagga cagccttttc ggtctgcacc tgctctcggc gcacggccag     2040

tacagcctcg cgatgggccg atatgaatcg gctcaccggg cgtttcacac ctgcggagaa     2100

cgtatgcgca gctggggtgt tgacgtgcct ggtctagccc tgtggcgtgt cgacgccgcc     2160

gaggcactgc tcagcctcga ccggaacgag ggccagcggc tcatcgacga acaactcgcc     2220

cgtccgatgg gacctcgttc ccgcgcactg acgctgcgga tcaaggcggc atacctcccg     2280

cggacgaagc ggatccccct gctccatgag gcagctgagc tgctgctctc ctgccccgac     2340

ccgtacgagc aagcgcgggt gctcgccgat ctgggcgaca cgctcagcgc gctcagacgc     2400

tatagccggg cgcggggagt tctccggcag gctcgtcacc tggccaccca gtgcggtgct     2460

gtcccgctgc tgcgccgact cgggggcgag cccggccgga tcgacgacgc cggcctgccg     2520

cagcggagca catcgttgac cgatgcggag cggcgggtgt cggccctggc cgcggccgga     2580

cagaccaacc gggagatcgc caaacagcta ttcgtcacgg ccagcaccgt ggaacagcac     2640

ctcacaagcg tcttccgcaa gctgggcgtt aagggccgca ggcagctacc gaccgcgctg     2700

gccgacgtgg aatag                                                      2715


<210>  22
<211>  2721
<212>  DNA
<213>  Streptomyces Sp. NRRL F-4729

<400>  22
gtgtatagcg gtacctgccg tgaaggatac gaactcgtcg cacgcgagga cgaactcggc       60

attctacaga ggtctctgga acaagcgagc agcggccagg gcgtcgtggt caccgtcacc      120

ggcccaatcg cctgcggcaa gacagaactg cttgacgcgg ctgccgcgaa ggctgaggcc      180

atcattctgc gcgcggtctg cgcgcccgaa gagcgggcta tgccgtacgc catgatcggg      240

cagctcatcg acgacccggc gctcgcgcat cgggcgccgg ggctggctga tcggatagcc      300

cagggcgggc agctgtcgct gagggccgag aaccgactgc gcagggatct cacccgtgcc      360

ctgctggcgc ttgccgtgca ccggcctgtg ctgatcggcg tcgatgatgt gcatcacgcc      420

gacaccgcct ctttgaactg tctgctgcat ttggcgcgcc gggtccgtcc ggcccggata      480

tccatgatct tcaccgagtt gcgcagcctc acccctactc agtcacgatt caaggcggag      540

ctgctcagcc tgccgtacca ccacgagatc gcgctgcgtc cattcggacc ggagcaatcg      600

gcggagctgg ctcgcgccgc cttcggcccg ggcctcgccg aggatgtgct cgcggggttg      660

tataaaacga ccaggggcaa tctgagtctc agccgtggac tgatcagcga tgtgcgggag      720

gccctggcca acggagagag cgctttcgag gcgggccgcg cgttccggct ggcgtacctc      780

agctcgctct accgctgtgg cccggtcgcg ctgcgggtcg cccgagtggc tgccgtgctg      840

ggcccaagcg ccaccaccac gctggtgcgc cggctaagcg ggctcagcgc ggagacgata      900

gaccgggcaa ccaagatcct caccgagggc gggctgctgc tcgaccagca gtttccgcac      960

ccggccgccc gctcggtggt gctcgatgac atgtccgccc aggaacgacg cggcctgcac     1020

actctcgccc tggaactgct ggacgaggcg ccggttgaag tgctcgcgca ccaccaggtc     1080

ggcgccggtc tcatacacgg gcccaaggct gcggagatgt tcgccaaggc cggcaaggct     1140

ctggtcgtac gcaacgagtt gggcgacgcg gccgaatacc tgcaactggc tcaccgggcc     1200

tccgacgatg tctccacccg ggccgcctta cgggtcgagg ccgtggcgat cgagcgccgc     1260

cgcaatccgc tggcctccag tcggcacatg gacgagctga gcgccgccgg ccgcgccggt     1320

ctgctttccc ccaagcatgc ggcgctggcc gtcttctggc tggccgacgg cgggcgatcc     1380

ggcgaggcag cccaggtgct ggcgtcggaa cgcccgctcg cgaccaccga tcagaaccgg     1440

gcccacctgc gatttgtcga ggtgactctc gcgctgttct ctcccggcgc cttcggatcg     1500

gaccggcgcc cacctccgct gacgccggac gaactcgcca gcctgccgaa ggcggcctgg     1560

caatgcgcgg tcgccgacaa cgcggccatg accgccttgc acggccatcc agaacttgcc     1620

accgctcagg cggaaacagt tctgcggcag gctgattcgg cagccgacgc gatccccgcc     1680

gcgctgatcg ccctgttgta cgcggagaac accgagtccg ctcatatctg ggccgacaag     1740

ctgggcagca tgaatgccgg ggtatcgaac gaggcggaag cgggctacgc cggcccgtgc     1800

gccgagatcg ccctgcggcg cggcgacctg gccacggcgt tcgaggctgg tagcaccgtc     1860

ctggacgacc ggtcactgcc gtcgctcggc atcaccgccg cattgctgtt gagcagcaag     1920

acggccgccg ctgtccggct gggcgaactc gagcgtgcgg agaagctgct cgccgagccg     1980

cttccgaacg gcgtccagga cagccttttc ggtctgcacc tgctctcggc gtacggccag     2040

tacagcctcg cgatgggccg atatgaatcg gctcaccggg cgtttcgcac ctgcggagaa     2100

cgtatgcgca gctgggatgt tgacgtgcct ggtctggccc tgtggcgtgt cgacgccgcc     2160

gaggcgctgc tcagcctcga ccggaacgag ggccagcggc tcatcgacga acaactcacc     2220

cgtccgatgg gacctcgttc ccgcgcgtta acgctgcgga tcaaggcggc atacctcccg     2280

cggacgaagc ggatccccct gctccatgag gcggccgagc tgctgctccc ctgccccgac     2340

ccgtacgagc aagcgcgggt gctcgccgat ctgggcgaca cgctcagcgc gctcagacgc     2400

tatagccggg cgcggggagt tctccggcag gctcgtcacc tggccaccca gtgcggtgct     2460

gtcccgctgc tgcgccgact cgggggcgag cccggccgga tcgacgacgc cggcctgccg     2520

cagcggagca catcgttgac cgatgcggag cggcgggtgg cggcgctggc cgcggccgga     2580

cagaccaacc gggagatcgc cgaacagctg ttcgtcacgg ccagcacagt ggaacagcac     2640

ctcacaagcg tcttccgcaa gctgggcgtc aagggccgca agcagctgcc gaccgcgctg     2700

gccgacgtgg aacagacctg a                                               2721


<210>  23
<211>  2721
<212>  DNA
<213>  Streptomyces Sp. NRRL F-4729

<400>  23
atgtatagcg gtacctgccg tgaaggatac gaactcgtcg cacgcgagga cgaactcggc       60

attctacaga ggtctctgga acaagcgagc agcggccagg gcgtcgtggt caccgtcacc      120

ggcccaatcg cctgcggcaa gacagaactg cttgacgcgg ctgccgcgaa ggctgaggcc      180

atcattctgc gcgcggtctg cgcgcccgaa gagcgggcta tgccgtacgc catgatcggg      240

cagctcatcg acgacccggc gctcgcgcat cgggcgccgg ggctggctga tcggatagcc      300

cagggcgggc agctgtcgct gagggccgag aaccgactgc gcagggatct cacccgtgcc      360

ctgctggcgc ttgccgtgca ccggcctgtg ctgatcggcg tcgatgatgt gcatcacgcc      420

gacaccgcct ctttgaactg tctgctgcat ttggcgcgcc gggtccgtcc ggcccggata      480

tccatgatct tcaccgagtt gcgcagcctc acccctactc agtcacgatt caaggcggag      540

ctgctcagcc tgccgtacca ccacgagatc gcgctgcgtc cattcggacc ggagcaatcg      600

gcggagctgg ctcgcgccgc cttcggcccg ggcctcgccg aggatgtgct cgcggggttg      660

tataaaacga ccaggggcaa tctgagtctc agccgtggac tgatcagcga tgtgcgggag      720

gccctggcca acggagagag cgctttcgag gcgggccgcg cgttccggct ggcgtacctc      780

agctcgctct accgctgtgg cccggtcgcg ctgcgggtcg cccgagtggc tgccgtgctg      840

ggcccaagcg ccaccaccac gctggtgcgc cggctaagcg ggctcagcgc ggagacgata      900

gaccgggcaa ccaagatcct caccgagggc gggctgctgc tcgaccagca gtttccgcac      960

ccggccgccc gctcggtggt gctcgatgac atgtccgccc aggaacgacg cggcctgcac     1020

actctcgccc tggaactgct ggacgaggcg ccggttgaag tgctcgcgca ccaccaggtc     1080

ggcgccggtc tcatacacgg gcccaaggct gcggagatgt tcgccaaggc cggcaaggct     1140

ctggtcgtac gcaacgagtt gggcgacgcg gccgaatacc tgcaactggc tcaccgggcc     1200

tccgacgatg tctccacccg ggccgccctg cgggtcgagg ccgtggcgat cgagcgccgc     1260

cgcaatccgc tggcctccag tcggcacatg gacgagctga gcgccgccgg ccgcgccggt     1320

ctgctttccc ccaagcatgc ggcgctggcc gtcttctggc tggccgacgg cgggcgatcc     1380

ggcgaggcag cccaggtgct ggcgtcggaa cgcccgctcg cgaccaccga tcagaaccgg     1440

gcccacctgc gatttgtcga ggtgactctc gcgctgttct ctcccggcgc cttcggatcg     1500

gaccggcgcc cacctccgct gacgccggac gaactcgcca gcctgccgaa ggcggcctgg     1560

caatgcgcgg tcgccgacaa cgcggccatg accgccttgc acggccatcc agaacttgcc     1620

accgctcagg cggaaacagt tctgcggcag gctgattcgg cagccgacgc gatccccgcc     1680

gcgctgatcg ccctgttgta cgcggagaac accgagtccg ctcatatctg ggccgacaag     1740

ctgggcagca tgaatgccgg ggtatcgaac gaggcggaag cgggctacgc cggcccgtgc     1800

gccgagatcg ccctgcggcg cggcgacctg gccacggcgt tcgaggctgg tagcaccgtc     1860

ctggacgacc ggtcactgcc gtcgctcggc atcaccgccg cattgctgtt gagcagcaag     1920

acggccgccg ctgtccggct gggcgaactc gagcgtgcgg agaagctgct cgccgagccg     1980

cttccgaacg gcgtccagga cagccttttc ggtctgcacc tgctctcggc gtacggccag     2040

tacagcctcg cgatgggccg atatgaatcg gctcaccggg cgtttcgcac ctgcggagaa     2100

cgtatgcgca gctgggatgt tgacgtgcct ggtctggccc tgtggcgtgt cgacgccgcc     2160

gaggcgctgc tcagcctcga ccggaacgag ggccagcggc tcatcgacga acaactcacc     2220

cgtccgatgg gacctcgttc ccgcgcgctg acgctgcgga tcaaggcggc atacctcccg     2280

cggacgaagc ggatccccct gctccatgag gcggccgagc tgctgctccc ctgccccgac     2340

ccgtacgagc aagcgcgggt gctcgccgat ctgggcgaca cgctcagcgc gctcagacgc     2400

tatagccggg cgcggggagt tctccggcag gctcgtcacc tggccaccca gtgcggtgct     2460

gtcccgctgc tgcgccgact cgggggcgag cccggccgga tcgacgacgc cggcctgccg     2520

cagcggagca catcgttgac cgatgcggag cggcgggtgg cggcgctggc cgcggccgga     2580

cagaccaacc gggagatcgc cgaacagctg ttcgtcacgg ccagcacagt ggaacagcac     2640

ctcacaagcg tcttccgcaa gctgggcgtc aagggccgca agcagctgcc gaccgcgctg     2700

gccgacgtgg aacagacctg a                                               2721


<210>  24
<211>  2715
<212>  DNA
<213>  Streptomyces filamentosus

<400>  24
gtgcgagcta ttaatgcgtc cgacaccggt cctgaactgg tcgcccgcga agacgaactg       60

ggacgtgtac gaagtgccct gaaccgagcg aacggcggcc aaggtgtcct gatctccatt      120

accggtccga tcgcctgcgg caagaccgaa ctgcttgagg ctgccgcctc ggaagttgac      180

gccatcactc tgcgcgcggt ctgtgccgcc gaggaacggg cgatacctta tgccctgatc      240

gggcagctta tcgacaaccc cgcgctcggc attccggttc cggatccggc cggcctgacc      300

gcccagggcg gacgactgtc atcgagcgcc gagaaccgac tgcgtcgcga cctcacccgt      360

gccctgctga cgctcgccac cgaccggctg gtgctgatct gtgtcgatga cgtgcagcac      420

gccgacaacg cctcgttgag ctgccttctg tatctggccc gacggcttgt cccggctcga      480

atcgctctgg tattcaccga gttgcgagtc ctcacctcgt ctcagttacg gttcaacgcg      540

gagctgctca gcttgcggaa ccactgcgag atcgcgctgc gcccactcgg cccggggcat      600

gcggccgagc tggcccgcgc caccctcggc cccggcctct ccgacgaaac actcacggag      660

ctgtaccggg tgaccggagg caacctgagt ctcagccgcg ggctgatcga cgatgtgcgg      720

gacgcctggg cacgagggga aacgggcgtc caggtgggcc gggcgttccg gctggcctac      780

ctcggttccc tccaccgctg tggtccgctg gcgttgcggg tcgcccgcgt agccgccgta      840

ctgggcccga gcgccaccag cgtcctggtg cgccggatca gtgggctcag cgcggaggcc      900

atggcccagg cgaccgatat cctcgctgac ggcggcctcc tgcgcgacca gcggttcaca      960

catccagcgg cccgctcggt ggtgctcgac gacatgtccg ccgaggaacg acgcagcgtg     1020

cacagcctcg ccctggaact gctggacgag gcaccggccg agatgctcgc gcaccaccgg     1080

gtcggcgccg gtctcgtgca cgggccgaag gccgcggaga cattcaccgg ggccggccgg     1140

gcactggccg ttcgcggcat gctgggcgag gcagccgact acctgcaact ggcgtaccgg     1200

gcctccggcg acgccgctac caaggccgcg atacgcgtcg agtccgtggc ggtcgagcgc     1260

cgacgcaatc cgctggtcgt cagtcgccat tgggacgagc tgagcgtcgc ggcccgcgcc     1320

ggtctgctct cctgcgagca cgtgtccagg acggcccgct ggctgaccgt cggtgggcgg     1380

cccggcgagg cggccagggt gctggcgtcg caacaccgac gggtcgtcac cgatcaggac     1440

cgggcccacc tgcgggtcgc cgagttctcg ctcgcgctgc tgtaccccgg tacgtccggc     1500

tcggaccggc gcccgcaccc gctcacgtcg gacgaactcg cggccctacc gactgcgacc     1560

agacactgcg cgatcgccga taacgctgtc atggctgcct tgcgtggtca tccggagctt     1620

gccaccgccg aggcagaagc cgttctgcag caagccgacg cggcggacgg cgctgctctc     1680

accgcgctga tggccctgct gtacgcggag agcatcgagg tcgctgaagt ctgggcggac     1740

aagctggcgg cagaggccgg agcatcgaac gggcaggacg cggagtacgc cggtatacgc     1800

gccgaaatcg ccctgcggcg cggcgatctg accgcggccg tcgagaccgc cggcatggtc     1860

ctggacggcc ggccgctgcc gtcgctcgac atcaccgcca cgttgctgtt ggccggcagg     1920

gcgtccgtcg ccgtccggct gggcgaactc gaccacgcgg aggagctgtt cgccgcgccg     1980

ccggaggacg ccttccagga cagcctcttc ggtctgcatc tgctctcggc gcacggccag     2040

tacagcctcg cgacaggccg gcccgagtcg gcataccggg cctttcgtgc ctgcggcgaa     2100

cgtatgcgcg attggggctt cgacgcgccc ggtgtggccc tgtggcgcgt cggcgccgcc     2160

gaggcgctgc tcggcctcga ccggaacgag ggccgacggc tcatcgacga acagctgagc     2220

cggacgatgg ccccccggtc ccacgcgttg acgctgcgga taaaagcggc gtacatgccg     2280

gagccgaagc gggtcgacct gctctacgaa gcggctgagc tgctgctctc ctgccgggac     2340

cagtatgagc gagcgcgggt gctcgccgat ctgggcgagg cgctcagcgc gctcgggaac     2400

taccggcagg cgcgaggtgt gctccggcag gctcggcatc tggccatgcg aaccggcgcg     2460

gacccgctgc tgcgccggct cggaatcagg cccggccggc aggacgaccc cgacccgcag     2520

ccgcggagca gatcgctgac caacgctgag cggcgtgcgg cgtcgctggc cgcgaccgga     2580

ctgaccaacc gggagatcgc cgaccggctc ttcgtcaccg ccagcaccgt ggagcagcac     2640

ctcaccaacg tcttccgcaa gctgggcgtc aagggccgca agcagctgcc ggccgagttg     2700

gacgacatgg aatag                                                      2715


<210>  25
<211>  2715
<212>  DNA
<213>  Streptomyces filamentosus

<400>  25
atgcgagcta ttaatgcgtc cgacaccggt cctgaactgg tcgcccgcga agacgaactg       60

ggacgtgtac gaagtgccct gaaccgagcg aacggcggcc aaggtgtcct gatctccatt      120

accggtccga tcgcctgcgg caagaccgaa ctgcttgagg ctgccgcctc ggaagttgac      180

gccatcactc tgcgcgcggt ctgtgccgcc gaggaacggg cgatacctta tgccctgatc      240

gggcagctta tcgacaaccc cgcgctcggc attccggttc cggatccggc cggcctgacc      300

gcccagggcg gacgactgtc atcgagcgcc gagaaccgac tgcgtcgcga cctcacccgt      360

gccctgctga cgctcgccac cgaccggctg gtgctgatct gtgtcgatga cgtgcagcac      420

gccgacaacg cctcgttgag ctgccttctg tatctggccc gacggcttgt cccggctcga      480

atcgctctgg tattcaccga gttgcgagtc ctcacctcgt ctcagctgcg gttcaacgcg      540

gagctgctca gcttgcggaa ccactgcgag atcgcgctgc gcccactcgg cccggggcat      600

gcggccgagc tggcccgcgc caccctcggc cccggcctct ccgacgaaac actcacggag      660

ctgtaccggg tgaccggagg caacctgagt ctcagccgcg ggctgatcga cgatgtgcgg      720

gacgcctggg cacgagggga aacgggcgtc caggtgggcc gggcgttccg gctggcctac      780

ctcggttccc tccaccgctg tggtccgctg gcgttgcggg tcgcccgcgt agccgccgta      840

ctgggcccga gcgccaccag cgtcctggtg cgccggatca gtgggctcag cgcggaggcc      900

atggcccagg cgaccgatat cctcgctgac ggcggcctcc tgcgcgacca gcggttcaca      960

catccagcgg cccgctcggt ggtgctcgac gacatgtccg ccgaggaacg acgcagcgtg     1020

cacagcctcg ccctggaact gctggacgag gcaccggccg agatgctcgc gcaccaccgg     1080

gtcggcgccg gtctcgtgca cgggccgaag gccgcggaga cattcaccgg ggccggccgg     1140

gcactggccg ttcgcggcat gctgggcgag gcagccgact acctgcaact ggcgtaccgg     1200

gcctccggcg acgccgctac caaggccgcg atacgcgtcg agtccgtggc ggtcgagcgc     1260

cgacgcaatc cgctggtcgt cagtcgccat tgggacgagc tgagcgtcgc ggcccgcgcc     1320

ggtctgctct cctgcgagca cgtgtccagg acggcccgct ggctgaccgt cggtgggcgg     1380

cccggcgagg cggccagggt gctggcgtcg caacaccgac gggtcgtcac cgatcaggac     1440

cgggcccacc tgcgggtcgc cgagttctcg ctcgcgctgc tgtaccccgg tacgtccggc     1500

tcggaccggc gcccgcaccc gctcacgtcg gacgaactcg cggccctacc gactgcgacc     1560

agacactgcg cgatcgccga taacgctgtc atggctgcct tgcgtggtca tccggagctt     1620

gccaccgccg aggcagaagc cgttctgcag caagccgacg cggcggacgg cgctgctctc     1680

accgcgctga tggccctgct gtacgcggag agcatcgagg tcgctgaagt ctgggcggac     1740

aagctggcgg cagaggccgg agcatcgaac gggcaggacg cggagtacgc cggtatacgc     1800

gccgaaatcg ccctgcggcg cggcgatctg accgcggccg tcgagaccgc cggcatggtc     1860

ctggacggcc ggccgctgcc gtcgctcgac atcaccgcca cgttgctgtt ggccggcagg     1920

gcgtccgtcg ccgtccggct gggcgaactc gaccacgcgg aggagctgtt cgccgcgccg     1980

ccggaggacg ccttccagga cagcctcttc ggtctgcatc tgctctcggc gcacggccag     2040

tacagcctcg cgacaggccg gcccgagtcg gcataccggg cctttcgtgc ctgcggcgaa     2100

cgtatgcgcg attggggctt cgacgcgccc ggtgtggccc tgtggcgcgt cggcgccgcc     2160

gaggcgctgc tcggcctcga ccggaacgag ggccgacggc tcatcgacga acagctgagc     2220

cggacgatgg ccccccggtc ccacgcgttg acgctgcgga taaaagcggc gtacatgccg     2280

gagccgaagc gggtcgacct gctctacgaa gcggctgagc tgctgctctc ctgccgggac     2340

cagtatgagc gagcgcgggt gctcgccgat ctgggcgagg cgctcagcgc gctcgggaac     2400

taccggcagg cgcgaggtgt gctccggcag gctcggcatc tggccatgcg aaccggcgcg     2460

gacccgctgc tgcgccggct cggaatcagg cccggccggc aggacgaccc cgacccgcag     2520

ccgcggagca gatcgctgac caacgctgag cggcgtgcgg cgtcgctggc cgcgaccgga     2580

ctgaccaacc gggagatcgc cgaccggctc ttcgtcaccg ccagcaccgt ggagcagcac     2640

ctcaccaacg tcttccgcaa gctgggcgtc aagggccgca agcagctgcc ggccgagttg     2700

gacgacatgg aatag                                                      2715


<210>  26
<211>  894
<212>  PRT
<213>  Streptomyces hygroscopicus

<400>  26

Met Pro Ala Val Glu Cys Tyr Glu Leu Asp Ala Arg Asp Asp Glu Leu 
1               5                   10                  15      


Arg Lys Leu Glu Glu Val Val Thr Gly Arg Ala Asn Gly Arg Gly Val 
            20                  25                  30          


Val Val Thr Ile Thr Gly Pro Ile Ala Cys Gly Lys Thr Glu Leu Leu 
        35                  40                  45              


Asp Ala Ala Ala Ala Lys Ala Asp Ala Ile Thr Leu Arg Ala Val Cys 
    50                  55                  60                  


Ser Ala Glu Glu Gln Ala Leu Pro Tyr Ala Leu Ile Gly Gln Leu Ile 
65                  70                  75                  80  


Asp Asn Pro Ala Leu Ala Ser His Ala Leu Glu Pro Ala Cys Pro Thr 
                85                  90                  95      


Leu Pro Gly Glu His Leu Ser Pro Glu Ala Glu Asn Arg Leu Arg Ser 
            100                 105                 110         


Asp Leu Thr Arg Thr Leu Leu Ala Leu Ala Ala Glu Arg Pro Val Leu 
        115                 120                 125             


Ile Gly Ile Asp Glu Ser His Ala Asn Ala Leu Cys Leu Leu His Leu 
    130                 135                 140                 


Ala Arg Arg Val Gly Ser Ala Arg Ile Ala Met Val Leu Thr Glu Leu 
145                 150                 155                 160 


Arg Arg Leu Thr Pro Ala His Ser Gln Phe Gln Ala Glu Leu Leu Ser 
                165                 170                 175     


Leu Gly His His Arg Glu Ile Ala Leu Arg Pro Leu Ser Pro Lys His 
            180                 185                 190         


Thr Ala Glu Leu Val Arg Ala Gly Leu Gly Pro Asp Val Asp Glu Asp 
        195                 200                 205             


Val Leu Thr Gly Leu Tyr Arg Ala Thr Gly Gly Asn Leu Asn Leu Thr 
    210                 215                 220                 


Arg Gly Leu Ile Asn Asp Val Arg Glu Ala Trp Glu Thr Gly Gly Thr 
225                 230                 235                 240 


Gly Ile Ser Ala Gly Arg Ala Tyr Arg Leu Ala Tyr Leu Gly Ser Leu 
                245                 250                 255     


Tyr Arg Cys Gly Pro Val Pro Leu Arg Val Ala Arg Val Ala Ala Val 
            260                 265                 270         


Leu Gly Gln Ser Ala Asn Thr Thr Leu Val Arg Trp Ile Ser Gly Leu 
        275                 280                 285             


Asn Ala Asp Ala Val Gly Glu Ala Thr Glu Ile Leu Thr Glu Gly Gly 
    290                 295                 300                 


Leu Leu His Asp Leu Arg Phe Pro His Pro Ala Ala Arg Ser Val Val 
305                 310                 315                 320 


Leu Asn Asp Met Ser Ala Gln Glu Arg Arg Arg Leu His Arg Ser Ala 
                325                 330                 335     


Leu Glu Val Leu Asp Asp Val Pro Val Glu Val Val Ala His His Gln 
            340                 345                 350         


Val Gly Ala Gly Leu Leu His Gly Pro Lys Ala Ala Glu Ile Phe Ala 
        355                 360                 365             


Lys Ala Gly Gln Glu Leu His Val Arg Gly Glu Leu Asp Thr Ala Ser 
    370                 375                 380                 


Asp Tyr Leu Gln Leu Ala His Gln Ala Ser Asp Asp Ala Val Thr Gly 
385                 390                 395                 400 


Met Arg Ala Glu Ala Val Ala Ile Glu Arg Arg Arg Asn Pro Leu Ala 
                405                 410                 415     


Ser Ser Arg His Leu Asp Glu Leu Thr Val Val Ala Arg Ala Gly Leu 
            420                 425                 430         


Leu Phe Pro Glu His Thr Ala Leu Met Ile Arg Trp Leu Gly Val Gly 
        435                 440                 445             


Gly Arg Ser Gly Glu Ala Ala Gly Leu Leu Ala Ser Gln Arg Pro Arg 
    450                 455                 460                 


Ala Val Thr Asp Gln Asp Arg Ala His Met Arg Ala Ala Glu Val Ser 
465                 470                 475                 480 


Leu Ala Leu Val Ser Pro Gly Thr Ser Gly Pro Asp Arg Arg Pro Arg 
                485                 490                 495     


Pro Leu Thr Pro Asp Glu Leu Ala Asn Leu Pro Lys Ala Ala Arg Leu 
            500                 505                 510         


Cys Ala Ile Ala Asp Asn Ala Val Met Ser Ala Leu Arg Gly Arg Pro 
        515                 520                 525             


Glu Leu Ala Ala Ala Glu Ala Glu Asn Val Leu Gln His Ala Asp Ser 
    530                 535                 540                 


Ala Ala Ala Gly Thr Thr Ala Leu Ala Ala Leu Thr Ala Leu Leu Tyr 
545                 550                 555                 560 


Ala Glu Asn Thr Asp Thr Ala Gln Leu Trp Ala Asp Lys Leu Val Ser 
                565                 570                 575     


Glu Thr Gly Ala Ser Asn Glu Glu Glu Ala Gly Tyr Ala Gly Pro Arg 
            580                 585                 590         


Ala Glu Ala Ala Leu Arg Arg Gly Asp Leu Ala Ala Ala Val Glu Ala 
        595                 600                 605             


Gly Ser Thr Val Leu Asp His Arg Arg Leu Ser Thr Leu Gly Ile Thr 
    610                 615                 620                 


Ala Ala Leu Pro Leu Ser Ser Ala Val Ala Ala Ala Ile Arg Leu Gly 
625                 630                 635                 640 


Glu Thr Glu Arg Ala Glu Lys Trp Leu Ala Gln Pro Leu Pro Gln Ala 
                645                 650                 655     


Ile Gln Asp Gly Leu Phe Gly Leu His Leu Leu Ser Ala Arg Gly Gln 
            660                 665                 670         


Tyr Ser Leu Ala Thr Gly Gln His Glu Ser Ala Tyr Thr Ala Phe Arg 
        675                 680                 685             


Thr Cys Gly Glu Arg Met Arg Asn Trp Gly Val Asp Val Pro Gly Leu 
    690                 695                 700                 


Ser Leu Trp Arg Val Asp Ala Ala Glu Ala Leu Leu His Gly Arg Asp 
705                 710                 715                 720 


Arg Asp Glu Gly Arg Arg Leu Val Asp Glu Gln Leu Thr Arg Ala Met 
                725                 730                 735     


Gly Pro Arg Ser Arg Ala Leu Thr Leu Arg Val Gln Ala Ala Tyr Ser 
            740                 745                 750         


Pro Pro Ala Lys Arg Val Asp Leu Leu Asp Glu Ala Ala Asp Leu Leu 
        755                 760                 765             


Leu Ser Cys Asn Asp Gln Tyr Glu Arg Ala Arg Val Leu Ala Asp Leu 
    770                 775                 780                 


Ser Glu Thr Phe Ser Ala Leu Arg His His Ser Arg Ala Arg Gly Leu 
785                 790                 795                 800 


Leu Arg Gln Ala Arg His Leu Ala Ala Gln Arg Gly Ala Ile Pro Leu 
                805                 810                 815     


Leu Arg Arg Leu Gly Ala Lys Pro Gly Gly Pro Gly Trp Leu Glu Glu 
            820                 825                 830         


Ser Gly Leu Pro Gln Arg Ile Lys Ser Leu Thr Asp Ala Glu Arg Arg 
        835                 840                 845             


Val Ala Ser Leu Ala Ala Gly Gly Gln Thr Asn Arg Val Ile Ala Asp 
    850                 855                 860                 


Gln Leu Phe Val Thr Ala Ser Thr Val Glu Gln His Leu Thr Asp Val 
865                 870                 875                 880 


Ser Thr Gly Ser Arg Pro Pro Ala Pro Ala Ala Glu Leu Val 
                885                 890                 


<210>  27
<211>  923
<212>  PRT
<213>  Streptomyces kanamyceticus

<400>  27

Met Val Pro Glu Val Arg Ala Ala Pro Asp Glu Leu Ile Ala Arg Asp 
1               5                   10                  15      


Asp Glu Leu Ser Arg Leu Gln Arg Ala Leu Thr Arg Ala Gly Ser Gly 
            20                  25                  30          


Arg Gly Gly Val Val Ala Ile Thr Gly Pro Ile Ala Ser Gly Lys Thr 
        35                  40                  45              


Ala Leu Leu Asp Ala Gly Ala Ala Lys Ser Gly Phe Val Ala Leu Arg 
    50                  55                  60                  


Ala Val Cys Ser Trp Glu Glu Arg Thr Leu Pro Tyr Gly Met Leu Gly 
65                  70                  75                  80  


Gln Leu Phe Asp His Pro Glu Leu Ala Ala Gln Ala Pro Asp Leu Ala 
                85                  90                  95      


His Phe Thr Ala Ser Cys Glu Ser Pro Gln Ala Gly Thr Asp Asn Arg 
            100                 105                 110         


Leu Arg Ala Glu Phe Thr Arg Thr Leu Leu Ala Leu Ala Ala Asp Trp 
        115                 120                 125             


Pro Val Leu Ile Gly Ile Asp Asp Val His His Ala Asp Ala Glu Ser 
    130                 135                 140                 


Leu Arg Cys Leu Leu His Leu Ala Arg Arg Ile Gly Pro Ala Arg Ile 
145                 150                 155                 160 


Ala Val Val Leu Thr Glu Leu Arg Arg Pro Thr Pro Ala Asp Ser Arg 
                165                 170                 175     


Phe Gln Ala Glu Leu Leu Ser Leu Arg Ser Tyr Gln Glu Ile Ala Leu 
            180                 185                 190         


Arg Pro Leu Thr Glu Ala Gln Thr Gly Glu Leu Val Arg Arg His Leu 
        195                 200                 205             


Gly Ala Glu Thr His Glu Asp Val Ser Ala Asp Thr Phe Arg Ala Thr 
    210                 215                 220                 


Gly Gly Asn Leu Leu Leu Gly His Gly Leu Ile Asn Asp Ile Arg Glu 
225                 230                 235                 240 


Ala Arg Thr Ala Gly Arg Pro Gly Val Val Ala Gly Arg Ala Tyr Arg 
                245                 250                 255     


Leu Ala Tyr Leu Ser Ser Leu Tyr Arg Cys Gly Pro Ser Ala Leu Arg 
            260                 265                 270         


Val Ala Arg Ala Ser Ala Val Leu Gly Ala Ser Ala Glu Ala Val Leu 
        275                 280                 285             


Val Gln Arg Met Thr Gly Leu Asn Lys Asp Ala Val Glu Gln Val Tyr 
    290                 295                 300                 


Glu Gln Leu Asn Glu Gly Arg Leu Leu Gln Gly Glu Arg Phe Pro His 
305                 310                 315                 320 


Pro Ala Ala Arg Ser Ile Val Leu Asp Asp Leu Ser Ala Leu Glu Arg 
                325                 330                 335     


Arg Asn Leu His Glu Ser Ala Leu Glu Leu Leu Arg Asp His Gly Val 
            340                 345                 350         


Ala Gly Asn Val Leu Ala Arg His Gln Ile Gly Ala Gly Arg Val His 
        355                 360                 365             


Gly Glu Glu Ala Val Glu Leu Phe Thr Gly Ala Ala Arg Glu His His 
    370                 375                 380                 


Leu Arg Gly Glu Leu Asp Asp Ala Ala Gly Tyr Leu Glu Leu Ala His 
385                 390                 395                 400 


Arg Ala Ser Asp Asp Pro Val Thr Arg Ala Ala Leu Arg Val Gly Ala 
                405                 410                 415     


Ala Ala Ile Glu Arg Leu Cys Asn Pro Val Arg Ala Gly Arg His Leu 
            420                 425                 430         


Pro Glu Leu Leu Thr Ala Ser Arg Ala Gly Leu Leu Ser Ser Glu His 
        435                 440                 445             


Ala Val Ser Leu Ala Asp Trp Leu Ala Met Gly Gly Arg Pro Gly Glu 
    450                 455                 460                 


Ala Ala Glu Val Leu Ala Thr Gln Arg Pro Ala Ala Asp Ser Glu Gln 
465                 470                 475                 480 


His Arg Ala Leu Leu Arg Ser Gly Glu Leu Ser Leu Ala Leu Val His 
                485                 490                 495     


Pro Gly Ala Trp Asp Pro Leu Arg Arg Thr Asp Arg Phe Ala Ala Gly 
            500                 505                 510         


Gly Leu Gly Ser Leu Pro Gly Pro Ala Arg His Arg Ala Val Ala Asp 
        515                 520                 525             


Gln Ala Val Ile Ala Ala Leu Arg Gly Arg Leu Asp Arg Ala Asp Ala 
    530                 535                 540                 


Asn Ala Glu Ser Val Leu Gln His Thr Asp Ala Thr Ala Asp Arg Thr 
545                 550                 555                 560 


Thr Ala Ile Met Ala Leu Leu Ala Leu Leu Tyr Ala Glu Asn Thr Asp 
                565                 570                 575     


Ala Val Gln Phe Trp Val Asp Lys Leu Ala Gly Asp Glu Gly Thr Arg 
            580                 585                 590         


Thr Pro Ala Asp Glu Ala Val His Ala Gly Phe Asn Ala Glu Ile Ala 
        595                 600                 605             


Leu Arg Arg Gly Asp Leu Met Arg Ala Val Glu Tyr Gly Glu Ala Ala 
    610                 615                 620                 


Leu Gly His Arg His Leu Pro Thr Trp Gly Met Ala Ala Ala Leu Pro 
625                 630                 635                 640 


Leu Ser Ser Thr Val Val Ala Ala Ile Arg Leu Gly Asp Leu Asp Arg 
                645                 650                 655     


Ala Glu Arg Trp Leu Ala Glu Pro Leu Pro Gln Gln Thr Pro Glu Ser 
            660                 665                 670         


Leu Phe Gly Leu His Leu Leu Trp Ala Arg Gly Gln His His Leu Ala 
        675                 680                 685             


Thr Gly Arg His Gly Ala Ala Tyr Thr Ala Phe Arg Glu Cys Gly Glu 
    690                 695                 700                 


Arg Met Arg Arg Trp Ala Val Asp Val Pro Gly Leu Ala Leu Trp Arg 
705                 710                 715                 720 


Val Asp Ala Ala Glu Ser Leu Leu Leu Leu Gly Arg Asp Arg Ala Glu 
                725                 730                 735     


Gly Leu Arg Leu Val Ser Glu Gln Leu Ser Arg Pro Met Arg Pro Arg 
            740                 745                 750         


Ala Arg Val Gln Thr Leu Arg Val Gln Ala Ala Tyr Ser Pro Pro Pro 
        755                 760                 765             


Gln Arg Ile Asp Leu Leu Glu Glu Ala Ala Asp Leu Leu Val Thr Cys 
    770                 775                 780                 


Asn Asp Gln Tyr Glu Leu Ala Asn Val Leu Ser Asp Leu Ala Glu Ala 
785                 790                 795                 800 


Ser Ser Met Val Arg Gln His Ser Arg Ala Arg Gly Leu Leu Arg Arg 
                805                 810                 815     


Ala Arg His Leu Ala Thr Gln Cys Gly Ala Val Pro Leu Leu Arg Arg 
            820                 825                 830         


Leu Gly Ala Glu Pro Ser Asp Ile Gly Gly Ala Trp Asp Ala Thr Leu 
        835                 840                 845             


Gly Gln Arg Ile Ala Ser Leu Thr Glu Ser Glu Arg Arg Val Ala Ala 
    850                 855                 860                 


Leu Ala Ala Val Gly Arg Thr Asn Arg Glu Ile Ala Glu Gln Leu Phe 
865                 870                 875                 880 


Val Thr Ala Ser Thr Val Glu Gln His Leu Thr Asn Val Phe Arg Lys 
                885                 890                 895     


Leu Ala Val Lys Gly Arg Gln Gln Leu Pro Lys Glu Leu Ala Asp Val 
            900                 905                 910         


Gly Glu Pro Ala Asp Arg Asp Arg Arg Cys Gly 
        915                 920             


<210>  28
<211>  913
<212>  PRT
<213>  Streptomyces ascomyceticus

<400>  28

Met Ile Ala Arg Leu Ser Pro Pro Asp Leu Ile Ala Arg Asp Asp Glu 
1               5                   10                  15      


Phe Gly Ser Leu His Arg Ala Leu Thr Arg Ala Gly Gly Gly Arg Gly 
            20                  25                  30          


Val Val Ala Ala Val Thr Gly Pro Ile Ala Cys Gly Lys Thr Glu Leu 
        35                  40                  45              


Leu Asp Ala Ala Ala Ala Lys Ala Gly Phe Val Thr Leu Arg Ala Val 
    50                  55                  60                  


Cys Ser Met Glu Glu Arg Ala Leu Pro Tyr Gly Met Leu Gly Gln Leu 
65                  70                  75                  80  


Leu Asp Gln Pro Glu Leu Ala Ala Arg Thr Pro Glu Leu Val Arg Leu 
                85                  90                  95      


Thr Ala Ser Cys Glu Asn Leu Pro Ala Asp Val Asp Asn Arg Leu Gly 
            100                 105                 110         


Thr Glu Leu Thr Arg Thr Val Leu Thr Leu Ala Ala Glu Arg Pro Val 
        115                 120                 125             


Leu Ile Gly Ile Asp Asp Val His His Ala Asp Ala Pro Ser Leu Arg 
    130                 135                 140                 


Cys Leu Leu His Leu Ala Arg Arg Ile Ser Arg Ala Arg Val Ala Ile 
145                 150                 155                 160 


Val Leu Thr Glu Leu Leu Arg Pro Thr Pro Ala His Ser Gln Phe Arg 
                165                 170                 175     


Ala Ala Leu Leu Ser Leu Arg His Tyr Gln Glu Ile Ala Leu Arg Pro 
            180                 185                 190         


Leu Thr Glu Ala Gln Thr Thr Glu Leu Val Arg Arg His Leu Gly Gln 
        195                 200                 205             


Asp Ala His Asp Asp Val Val Ala Gln Ala Phe Arg Ala Thr Gly Gly 
    210                 215                 220                 


Asn Leu Leu Leu Gly His Gly Leu Ile Asp Asp Ile Arg Glu Ala Arg 
225                 230                 235                 240 


Thr Arg Thr Ser Gly Cys Leu Glu Val Val Ala Gly Arg Ala Tyr Arg 
                245                 250                 255     


Leu Ala Tyr Leu Gly Ser Leu Tyr Arg Cys Gly Pro Ala Ala Leu Ser 
            260                 265                 270         


Val Ala Arg Ala Ser Ala Val Leu Gly Glu Ser Val Glu Leu Thr Leu 
        275                 280                 285             


Val Gln Arg Met Thr Gly Leu Asp Thr Glu Ala Val Glu Gln Ala His 
    290                 295                 300                 


Glu Gln Leu Val Glu Gly Arg Leu Leu Arg Glu Gly Arg Phe Pro His 
305                 310                 315                 320 


Pro Ala Ala Arg Ser Val Val Leu Asp Asp Leu Ser Ala Ala Glu Arg 
                325                 330                 335     


Arg Gly Leu His Glu Leu Ala Leu Glu Leu Leu Arg Asp Arg Gly Val 
            340                 345                 350         


Ala Ser Lys Val Leu Ala Arg His Gln Met Gly Thr Gly Arg Val His 
        355                 360                 365             


Gly Ala Glu Val Ala Gly Leu Phe Thr Asp Ala Ala Arg Glu His His 
    370                 375                 380                 


Leu Arg Gly Glu Leu Asp Glu Ala Val Thr Tyr Leu Glu Phe Ala Tyr 
385                 390                 395                 400 


Arg Ala Ser Asp Asp Pro Ala Val His Ala Ala Leu Arg Val Asp Thr 
                405                 410                 415     


Ala Ala Ile Glu Arg Leu Cys Asp Pro Ala Arg Ser Gly Arg His Val 
            420                 425                 430         


Pro Glu Leu Leu Thr Ala Ser Arg Glu Arg Leu Leu Ser Ser Glu His 
        435                 440                 445             


Ala Val Ser Leu Ala Cys Trp Leu Ala Met Asp Gly Arg Pro Gly Glu 
    450                 455                 460                 


Ala Ala Glu Val Leu Ala Ala Gln Arg Ser Ala Ala Pro Ser Glu Gln 
465                 470                 475                 480 


Gly Arg Ala His Leu Arg Val Ala Asp Leu Ser Leu Ala Leu Ile Tyr 
                485                 490                 495     


Pro Gly Ala Ala Asp Pro Pro Arg Pro Ala Asp Pro Pro Ala Glu Asp 
            500                 505                 510         


Glu Val Ala Ser Phe Ser Gly Ala Val Arg His Arg Ala Val Ala Asp 
        515                 520                 525             


Lys Ala Leu Ser Asn Ala Leu Arg Gly Trp Ser Glu Gln Ala Glu Ala 
    530                 535                 540                 


Lys Ala Glu Tyr Val Leu Gln His Ser Arg Val Thr Thr Asp Arg Thr 
545                 550                 555                 560 


Thr Thr Met Met Ala Leu Leu Ala Leu Leu Tyr Ala Glu Asp Thr Asp 
                565                 570                 575     


Ala Val Gln Ser Trp Val Asp Lys Leu Ala Gly Asp Asp Asn Met Arg 
            580                 585                 590         


Thr Pro Ala Asp Glu Ala Val His Ala Gly Phe Arg Ala Glu Ala Ala 
        595                 600                 605             


Leu Arg Arg Gly Asp Leu Thr Ala Ala Val Glu Cys Gly Glu Ala Ala 
    610                 615                 620                 


Leu Ala Pro Arg Val Val Pro Ser Trp Gly Met Ala Ala Ala Leu Pro 
625                 630                 635                 640 


Leu Ser Ser Thr Val Ala Ala Ala Ile Arg Leu Gly Asp Leu Asp Arg 
                645                 650                 655     


Ala Glu Arg Trp Leu Ala Glu Pro Leu Pro Glu Glu Thr Ser Asp Ser 
            660                 665                 670         


Leu Phe Gly Leu His Met Val Trp Ala Arg Gly Gln His His Leu Ala 
        675                 680                 685             


Ala Gly Arg Tyr Arg Ala Ala Tyr Asn Ala Phe Arg Asp Cys Gly Glu 
    690                 695                 700                 


Arg Met Arg Arg Trp Ser Val Asp Val Pro Gly Leu Ala Leu Trp Arg 
705                 710                 715                 720 


Val Asp Ala Ala Glu Ala Leu Leu Leu Leu Gly Arg Gly Arg Asp Glu 
                725                 730                 735     


Gly Leu Arg Leu Ile Ser Glu Gln Leu Ser Arg Pro Met Gly Ser Arg 
            740                 745                 750         


Ala Arg Val Met Thr Leu Arg Val Gln Ala Ala Tyr Ser Pro Pro Ala 
        755                 760                 765             


Lys Arg Ile Glu Leu Leu Asp Glu Ala Ala Asp Leu Leu Ile Met Cys 
    770                 775                 780                 


Arg Asp Gln Tyr Glu Leu Ala Arg Val Leu Ala Asp Met Gly Glu Ala 
785                 790                 795                 800 


Cys Gly Met Leu Arg Arg His Ser Arg Ala Arg Gly Leu Phe Arg Arg 
                805                 810                 815     


Ala Arg His Leu Ala Thr Gln Cys Gly Ala Val Pro Leu Leu Arg Arg 
            820                 825                 830         


Leu Gly Gly Glu Ser Ser Asp Ala Asp Gly Thr Gln Asp Val Thr Pro 
        835                 840                 845             


Ala Gln Arg Ile Thr Ser Leu Thr Glu Ala Glu Arg Arg Val Ala Ser 
    850                 855                 860                 


His Ala Ala Val Gly Arg Thr Asn Lys Glu Ile Ala Ser Gln Leu Phe 
865                 870                 875                 880 


Val Thr Ser Ser Thr Val Glu Gln His Leu Thr Asn Val Phe Arg Lys 
                885                 890                 895     


Leu Gly Val Lys Gly Arg Gln Gln Leu Pro Lys Glu Leu Ser Asp Ala 
            900                 905                 910         


Gly 
    


<210>  29
<211>  901
<212>  PRT
<213>  Micromonospora sp. S92-306401

<400>  29

Met Glu Phe Tyr Asp Leu Val Ala Arg Asp Asp Glu Leu Arg Arg Leu 
1               5                   10                  15      


Asp Gln Ala Leu Gly Arg Ala Ala Gly Gly Arg Gly Val Val Val Thr 
            20                  25                  30          


Val Thr Gly Pro Val Gly Cys Gly Lys Thr Glu Leu Leu Asp Ala Ala 
        35                  40                  45              


Ala Ala Glu Glu Glu Phe Ile Thr Leu Arg Ala Val Cys Ser Ala Glu 
    50                  55                  60                  


Glu Arg Ala Leu Pro Tyr Ala Val Ile Gly Gln Leu Leu Asp His Pro 
65                  70                  75                  80  


Val Leu Ser Ala Arg Ala Pro Asp Leu Ala Cys Val Thr Ala Pro Gly 
                85                  90                  95      


Arg Thr Leu Pro Ala Asp Thr Glu Asn Arg Leu Arg Arg Asp Leu Thr 
            100                 105                 110         


Arg Ala Leu Leu Ala Leu Ala Ser Glu Arg Pro Val Leu Ile Cys Ile 
        115                 120                 125             


Asp Asp Val His Gln Ala Asp Thr Ala Ser Leu Asn Cys Leu Leu His 
    130                 135                 140                 


Leu Ala Arg Arg Val Ala Ser Ala Arg Ile Ala Met Ile Leu Thr Glu 
145                 150                 155                 160 


Leu Arg Arg Leu Thr Pro Ala His Ser Arg Phe Glu Ala Glu Leu Leu 
                165                 170                 175     


Ser Leu Arg His Arg His Glu Ile Ala Leu Arg Pro Leu Gly Pro Ala 
            180                 185                 190         


Asp Thr Ala Glu Leu Ala Arg Ala Arg Leu Gly Ala Gly Val Thr Ala 
        195                 200                 205             


Asp Glu Leu Ala Gln Val His Glu Ala Thr Ser Gly Asn Pro Asn Leu 
    210                 215                 220                 


Val Gly Gly Leu Val Asn Asp Val Arg Glu Ala Trp Ala Ala Gly Gly 
225                 230                 235                 240 


Thr Gly Ile Ala Ala Gly Arg Ala Tyr Arg Leu Ala Tyr Leu Ser Ser 
                245                 250                 255     


Val Tyr Arg Cys Gly Pro Val Pro Leu Arg Ile Ala Gln Ala Ala Ala 
            260                 265                 270         


Val Leu Gly Pro Ser Ala Thr Val Thr Leu Val Arg Arg Ile Ser Gly 
        275                 280                 285             


Leu Asp Ala Glu Thr Val Asp Glu Ala Thr Ala Ile Leu Thr Glu Gly 
    290                 295                 300                 


Gly Leu Leu Arg Asp His Arg Phe Pro His Pro Ala Ala Arg Ser Val 
305                 310                 315                 320 


Val Leu Asp Asp Met Ser Ala Gln Glu Arg Arg Arg Leu His Arg Ser 
                325                 330                 335     


Thr Leu Asp Val Leu Asp Gly Val Pro Val Asp Val Leu Ala His His 
            340                 345                 350         


Gln Ala Gly Ala Gly Leu Leu His Gly Pro Gln Ala Ala Glu Met Phe 
        355                 360                 365             


Ala Arg Ala Ser Gln Glu Leu Arg Val Arg Gly Glu Leu Asp Ala Ala 
    370                 375                 380                 


Thr Glu Tyr Leu Gln Leu Ala Tyr Arg Ala Ser Asp Asp Ala Gly Ala 
385                 390                 395                 400 


Arg Ala Ala Leu Gln Val Glu Thr Val Ala Gly Glu Arg Arg Arg Asn 
                405                 410                 415     


Pro Leu Ala Ala Ser Arg His Leu Asp Glu Leu Ala Ala Ala Ala Arg 
            420                 425                 430         


Ala Gly Leu Leu Ser Ala Glu His Ala Ala Leu Val Val His Trp Leu 
        435                 440                 445             


Ala Asp Ala Gly Arg Pro Gly Glu Ala Ala Glu Val Leu Ala Leu Gln 
    450                 455                 460                 


Arg Ala Leu Ala Val Thr Asp His Asp Arg Ala Arg Leu Arg Ala Ala 
465                 470                 475                 480 


Glu Val Ser Leu Ala Leu Phe His Pro Gly Val Pro Gly Ser Asp Pro 
                485                 490                 495     


Arg Pro Leu Ala Pro Glu Glu Leu Ala Ser Leu Ser Leu Ser Ala Arg 
            500                 505                 510         


His Gly Val Thr Ala Asp Asn Ala Val Leu Ala Ala Leu Arg Gly Arg 
        515                 520                 525             


Pro Glu Ser Ala Ala Ala Glu Ala Glu Asn Val Leu Arg Asn Ala Asp 
    530                 535                 540                 


Ala Ala Ala Ser Gly Pro Thr Ala Leu Ala Ala Leu Thr Ala Leu Leu 
545                 550                 555                 560 


Tyr Ala Glu Asn Thr Asp Ala Ala Gln Leu Trp Ala Asp Lys Leu Ala 
                565                 570                 575     


Ala Gly Ile Gly Ala Gly Glu Gly Glu Ala Gly Tyr Ala Gly Pro Arg 
            580                 585                 590         


Thr Val Ala Ala Leu Arg Arg Gly Asp Leu Thr Thr Ala Val Gln Ala 
        595                 600                 605             


Ala Gly Ala Val Leu Asp Arg Gly Arg Pro Ser Ser Leu Gly Ile Thr 
    610                 615                 620                 


Ala Val Leu Pro Leu Ser Gly Ala Val Ala Ala Ala Ile Arg Leu Gly 
625                 630                 635                 640 


Glu Leu Glu Arg Ala Glu Lys Trp Leu Ala Glu Pro Leu Pro Glu Ala 
                645                 650                 655     


Val His Asp Ser Leu Phe Gly Leu His Leu Leu Met Ala Arg Gly Arg 
            660                 665                 670         


Tyr Ser Leu Ala Val Gly Arg His Glu Ala Ala Tyr Ala Ala Phe Arg 
        675                 680                 685             


Asp Cys Gly Glu Arg Met Arg Arg Trp Asp Val Asp Val Pro Gly Leu 
    690                 695                 700                 


Ala Leu Trp Arg Val Asp Ala Ala Glu Ala Leu Leu Pro Gly Asp Asp 
705                 710                 715                 720 


Arg Ala Glu Gly Arg Arg Leu Ile Asp Glu Gln Leu Thr Arg Pro Met 
                725                 730                 735     


Gly Pro Arg Ser Arg Ala Leu Thr Leu Arg Val Arg Ala Ala Tyr Ala 
            740                 745                 750         


Pro Pro Ala Lys Arg Ile Asp Leu Leu Asp Glu Ala Ala Asp Leu Leu 
        755                 760                 765             


Leu Ser Ser Asn Asp Gln Tyr Glu Arg Ala Arg Val Leu Ala Asp Leu 
    770                 775                 780                 


Ser Glu Ala Phe Ser Ala Leu Arg Gln Asn Gly Arg Ala Arg Gly Ile 
785                 790                 795                 800 


Leu Arg Gln Ala Arg His Leu Ala Ala Gln Cys Gly Ala Val Pro Leu 
                805                 810                 815     


Leu Arg Arg Leu Gly Val Lys Ala Gly Arg Ser Gly Arg Leu Gly Arg 
            820                 825                 830         


Pro Pro Gln Gly Ile Arg Ser Leu Thr Glu Ala Glu Arg Arg Val Ala 
        835                 840                 845             


Thr Leu Ala Ala Ala Gly Gln Thr Asn Arg Glu Ile Ala Asp Gln Leu 
    850                 855                 860                 


Phe Val Thr Ala Ser Thr Val Glu Gln His Leu Thr Asn Val Phe Arg 
865                 870                 875                 880 


Lys Leu Gly Val Lys Gly Arg Gln Gln Leu Pro Ala Glu Leu Ala Asp 
                885                 890                 895     


Leu Arg Pro Pro Gly 
            900     


<210>  30
<211>  906
<212>  PRT
<213>  Streptomyces violaceusniger

<400>  30

Met Tyr Ser Gly Thr Cys Arg Glu Gly Tyr Glu Leu Val Ala Arg Glu 
1               5                   10                  15      


Asp Glu Leu Gly Ile Leu Gln Arg Ser Leu Glu Gln Ala Ser Ser Gly 
            20                  25                  30          


Gln Gly Val Val Val Thr Val Thr Gly Pro Ile Ala Cys Gly Lys Thr 
        35                  40                  45              


Glu Leu Leu Asp Ala Ala Ala Ala Lys Ala Glu Ala Ile Ile Leu Arg 
    50                  55                  60                  


Ala Val Cys Ala Pro Glu Glu Arg Ala Met Pro Tyr Ala Met Ile Gly 
65                  70                  75                  80  


Gln Leu Ile Asp Asp Pro Ala Leu Ala His Arg Ala Pro Gly Leu Ala 
                85                  90                  95      


Asp Arg Ile Ala Gln Gly Gly Gln Leu Ser Leu Arg Ala Glu Asn Arg 
            100                 105                 110         


Leu Arg Arg Asp Leu Thr Arg Ala Leu Leu Ala Leu Ala Val Asp Arg 
        115                 120                 125             


Pro Val Leu Ile Gly Val Asp Asp Val His His Ala Asp Thr Ala Ser 
    130                 135                 140                 


Leu Asn Cys Leu Leu His Leu Ala Arg Arg Val Arg Pro Ala Arg Ile 
145                 150                 155                 160 


Ser Met Ile Phe Thr Glu Leu Arg Ser Leu Thr Pro Thr Gln Ser Arg 
                165                 170                 175     


Phe Lys Ala Glu Leu Leu Ser Leu Pro Tyr His His Glu Ile Ala Leu 
            180                 185                 190         


Arg Pro Phe Gly Pro Glu Gln Ser Ala Glu Leu Ala Arg Ala Ala Phe 
        195                 200                 205             


Gly Pro Gly Leu Ala Glu Asp Val Leu Val Gly Leu Tyr Lys Thr Thr 
    210                 215                 220                 


Arg Gly Asn Leu Ser Leu Ser Arg Gly Leu Ile Ser Asp Val Arg Glu 
225                 230                 235                 240 


Ala Leu Ala Asn Gly Glu Ser Ala Phe Glu Ala Gly Arg Ala Phe Arg 
                245                 250                 255     


Leu Ala Tyr Leu Gly Ser Leu Tyr Arg Cys Gly Pro Val Ala Leu Arg 
            260                 265                 270         


Val Ala Arg Val Ala Ala Val Leu Gly Pro Ser Ala Thr Thr Thr Leu 
        275                 280                 285             


Val Arg Arg Leu Ser Gly Leu Ser Ala Glu Thr Ile Asp Arg Ala Thr 
    290                 295                 300                 


Lys Ile Leu Thr Glu Gly Gly Leu Leu Leu Asp Gln Gln Phe Pro His 
305                 310                 315                 320 


Pro Ala Ala Arg Ser Val Val Leu Asp Asp Met Ser Ala Gln Glu Arg 
                325                 330                 335     


Arg Gly Leu His Thr Leu Ala Leu Glu Leu Leu Asp Glu Ala Pro Val 
            340                 345                 350         


Glu Val Leu Ala His His Gln Val Gly Ala Gly Leu Ile His Gly Pro 
        355                 360                 365             


Lys Ala Ala Glu Met Phe Ala Lys Ala Gly Lys Ala Leu Val Val Arg 
    370                 375                 380                 


Asn Glu Leu Gly Asp Ala Ala Glu Tyr Leu Gln Leu Ala His Arg Ala 
385                 390                 395                 400 


Ser Asp Asp Val Ser Thr Arg Ala Ala Leu Arg Val Glu Ala Val Ala 
                405                 410                 415     


Ile Glu Arg Arg Arg Asn Pro Leu Ala Ser Ser Arg His Met Asp Glu 
            420                 425                 430         


Leu Ser Ala Ala Gly Arg Ala Gly Leu Leu Ser Pro Lys His Ala Ala 
        435                 440                 445             


Leu Ala Val Phe Trp Leu Ala Asp Gly Gly Arg Ser Gly Glu Ala Ala 
    450                 455                 460                 


Glu Val Leu Ala Ser Glu Arg Pro Leu Ala Thr Thr Asp Gln Asn Arg 
465                 470                 475                 480 


Ala His Leu Arg Phe Val Glu Val Thr Leu Ala Leu Phe Ser Pro Gly 
                485                 490                 495     


Ala Phe Gly Ser Asp Arg Arg Pro Pro Pro Leu Thr Pro Asp Glu Leu 
            500                 505                 510         


Ala Ser Leu Pro Lys Ala Ala Trp Gln Cys Ala Val Ala Asp Asn Ala 
        515                 520                 525             


Ala Met Thr Ala Leu His Gly His Pro Glu Leu Ala Thr Ala Gln Ala 
    530                 535                 540                 


Glu Thr Val Leu Arg Gln Ala Asp Ser Ala Ala Asp Ala Ile Pro Ala 
545                 550                 555                 560 


Ala Leu Ile Ala Leu Leu Tyr Ala Glu Asn Thr Glu Ser Ala His Ile 
                565                 570                 575     


Trp Ala Asp Lys Leu Gly Ser Thr Asn Gly Gly Val Ser Asn Glu Ala 
            580                 585                 590         


Glu Ala Gly Tyr Ala Gly Pro Cys Ala Glu Ile Ala Leu Arg Arg Gly 
        595                 600                 605             


Asp Leu Ala Thr Ala Phe Glu Ala Gly Ser Thr Val Leu Asp Asp Arg 
    610                 615                 620                 


Ser Leu Pro Ser Leu Gly Ile Thr Ala Ala Leu Leu Leu Ser Ser Lys 
625                 630                 635                 640 


Thr Ala Ala Ala Val Arg Leu Gly Glu Leu Glu Arg Ala Glu Lys Leu 
                645                 650                 655     


Leu Ala Glu Pro Leu Pro Asn Gly Val Gln Asp Ser Leu Phe Gly Leu 
            660                 665                 670         


His Leu Leu Ser Ala Tyr Gly Gln Tyr Ser Leu Ala Met Gly Arg Tyr 
        675                 680                 685             


Glu Ser Ala Leu Arg Ala Phe His Thr Cys Gly Glu Arg Met Arg Ser 
    690                 695                 700                 


Trp Asp Val Asp Val Pro Gly Leu Ala Leu Trp Arg Val Asp Ala Ala 
705                 710                 715                 720 


Glu Ala Leu Leu Ser Leu Asp Arg Asn Glu Gly Gln Arg Leu Ile Asp 
                725                 730                 735     


Glu Gln Leu Thr Arg Pro Met Gly Pro Arg Ser Arg Ala Leu Thr Leu 
            740                 745                 750         


Arg Ile Lys Ala Ala Tyr Leu Pro Arg Thr Lys Arg Ile Pro Leu Leu 
        755                 760                 765             


His Glu Ala Ala Glu Leu Leu Leu Pro Cys Pro Asp Pro Tyr Glu Gln 
    770                 775                 780                 


Ala Arg Val Leu Ala Asp Leu Gly Asp Thr Leu Ser Ala Leu Arg Arg 
785                 790                 795                 800 


Tyr Ser Arg Ala Arg Gly Val Leu Arg Gln Ala Arg His Leu Ala Ala 
                805                 810                 815     


Gln Cys Gly Ala Val Pro Leu Leu Arg Arg Leu Gly Gly Glu Pro Gly 
            820                 825                 830         


Arg Ile Asp Asp Ala Gly Leu Pro Gln Arg Ser Thr Ser Leu Thr Asp 
        835                 840                 845             


Ala Glu Arg Arg Val Ala Ala Leu Ala Ala Ala Gly Gln Thr Asn Arg 
    850                 855                 860                 


Glu Ile Ala Lys Gln Leu Phe Val Thr Ala Ser Thr Val Glu Gln His 
865                 870                 875                 880 


Leu Thr Ser Val Phe Arg Lys Leu Gly Val Lys Gly Arg Lys Gln Leu 
                885                 890                 895     


Pro Thr Ala Leu Ala Asp Val Glu Gln Thr 
            900                 905     


<210>  31
<211>  914
<212>  PRT
<213>  Streptomyces hygroscopicus

<400>  31

Met Pro Ala Val Glu Ser Tyr Glu Leu Asp Ala Arg Asp Asp Glu Leu 
1               5                   10                  15      


Arg Arg Leu Glu Glu Ala Val Gly Gln Ala Gly Asn Gly Arg Gly Val 
            20                  25                  30          


Val Val Thr Ile Thr Gly Pro Ile Ala Cys Gly Lys Thr Glu Leu Leu 
        35                  40                  45              


Asp Ala Ala Ala Ala Lys Ser Asp Ala Ile Thr Leu Arg Ala Val Cys 
    50                  55                  60                  


Ser Glu Glu Glu Arg Ala Leu Pro Tyr Ala Leu Ile Gly Gln Leu Ile 
65                  70                  75                  80  


Asp Asn Pro Ala Val Ala Ser Gln Leu Pro Asp Pro Val Ser Met Ala 
                85                  90                  95      


Leu Pro Gly Glu His Leu Ser Pro Glu Ala Glu Asn Arg Leu Arg Gly 
            100                 105                 110         


Asp Leu Thr Arg Thr Leu Leu Ala Leu Ala Ala Glu Arg Pro Val Leu 
        115                 120                 125             


Ile Gly Ile Asp Asp Met His His Ala Asp Thr Ala Ser Leu Asn Cys 
    130                 135                 140                 


Leu Leu His Leu Ala Arg Arg Val Gly Pro Ala Arg Ile Ala Met Val 
145                 150                 155                 160 


Leu Thr Glu Leu Arg Arg Leu Thr Pro Ala His Ser Gln Phe His Ala 
                165                 170                 175     


Glu Leu Leu Ser Leu Gly His His Arg Glu Ile Ala Leu Arg Pro Leu 
            180                 185                 190         


Gly Pro Lys His Ile Ala Glu Leu Ala Arg Ala Gly Leu Gly Pro Asp 
        195                 200                 205             


Val Asp Glu Asp Val Leu Thr Gly Leu Tyr Arg Ala Thr Gly Gly Asn 
    210                 215                 220                 


Leu Asn Leu Gly His Gly Leu Ile Lys Asp Val Arg Glu Ala Trp Ala 
225                 230                 235                 240 


Thr Gly Gly Thr Gly Ile Asn Ala Gly Arg Ala Tyr Arg Leu Ala Tyr 
                245                 250                 255     


Leu Gly Ser Leu Tyr Arg Cys Gly Pro Val Pro Leu Arg Val Ala Arg 
            260                 265                 270         


Val Ala Ala Val Leu Gly Gln Ser Ala Asn Thr Thr Leu Val Arg Trp 
        275                 280                 285             


Ile Ser Gly Leu Asn Ala Asp Ala Val Gly Glu Ala Thr Glu Ile Leu 
    290                 295                 300                 


Thr Glu Gly Gly Leu Leu His Asp Leu Arg Phe Pro His Pro Ala Ala 
305                 310                 315                 320 


Arg Ser Val Val Leu Asn Asp Leu Ser Ala Arg Glu Arg Arg Arg Leu 
                325                 330                 335     


His Arg Ser Ala Leu Glu Val Leu Asp Asp Val Pro Val Glu Val Val 
            340                 345                 350         


Ala His His Gln Ala Gly Ala Gly Phe Ile His Gly Pro Lys Ala Ala 
        355                 360                 365             


Glu Ile Phe Ala Lys Ala Gly Gln Glu Leu His Val Arg Gly Glu Leu 
    370                 375                 380                 


Asp Ala Ala Ser Asp Tyr Leu Gln Leu Ala His His Ala Ser Asp Asp 
385                 390                 395                 400 


Ala Val Thr Arg Ala Ala Leu Arg Val Glu Ala Val Ala Ile Glu Arg 
                405                 410                 415     


Arg Arg Asn Pro Leu Ala Ser Ser Arg His Leu Asp Glu Leu Thr Val 
            420                 425                 430         


Ala Ala Arg Ala Gly Leu Leu Ser Leu Glu His Ala Ala Leu Met Ile 
        435                 440                 445             


Arg Trp Leu Ala Leu Gly Gly Arg Ser Gly Glu Ala Ala Glu Val Leu 
    450                 455                 460                 


Ala Ala Gln Arg Pro Arg Ala Val Thr Asp Gln Asp Arg Ala His Leu 
465                 470                 475                 480 


Arg Ala Ala Glu Val Ser Leu Ala Leu Val Ser Pro Gly Ala Ser Gly 
                485                 490                 495     


Val Ser Pro Gly Ala Ser Gly Pro Asp Arg Arg Pro Arg Pro Leu Pro 
            500                 505                 510         


Pro Asp Glu Leu Ala Asn Leu Pro Lys Ala Ala Arg Leu Cys Ala Ile 
        515                 520                 525             


Ala Asp Asn Ala Val Ile Ser Ala Leu His Gly Arg Pro Glu Leu Ala 
    530                 535                 540                 


Ser Ala Glu Ala Glu Asn Val Leu Lys Gln Ala Asp Ser Ala Ala Asp 
545                 550                 555                 560 


Gly Ala Thr Ala Leu Ser Ala Leu Thr Ala Leu Leu Tyr Ala Glu Asn 
                565                 570                 575     


Thr Asp Thr Ala Gln Leu Trp Ala Asp Lys Leu Val Ser Glu Thr Gly 
            580                 585                 590         


Ala Ser Asn Glu Glu Glu Gly Ala Gly Tyr Ala Gly Pro Arg Ala Glu 
        595                 600                 605             


Thr Ala Leu Arg Arg Gly Asp Leu Ala Ala Ala Val Glu Ala Gly Ser 
    610                 615                 620                 


Ala Ile Leu Asp His Arg Arg Gly Ser Leu Leu Gly Ile Thr Ala Ala 
625                 630                 635                 640 


Leu Pro Leu Ser Ser Ala Val Ala Ala Ala Ile Arg Leu Gly Glu Thr 
                645                 650                 655     


Glu Arg Ala Glu Lys Trp Leu Ala Glu Pro Leu Pro Glu Ala Ile Arg 
            660                 665                 670         


Asp Ser Leu Phe Gly Leu His Leu Leu Ser Ala Arg Gly Gln Tyr Cys 
        675                 680                 685             


Leu Ala Thr Gly Arg His Glu Ser Ala Tyr Thr Ala Phe Arg Thr Cys 
    690                 695                 700                 


Gly Glu Arg Met Arg Asn Trp Gly Val Asp Val Pro Gly Leu Ser Leu 
705                 710                 715                 720 


Trp Arg Val Asp Ala Ala Glu Ala Leu Leu His Gly Arg Asp Arg Asp 
                725                 730                 735     


Glu Gly Arg Arg Leu Ile Asp Glu Gln Leu Thr His Ala Met Gly Pro 
            740                 745                 750         


Arg Ser Arg Ala Leu Thr Leu Arg Val Gln Ala Ala Tyr Ser Pro Gln 
        755                 760                 765             


Ala Gln Arg Val Asp Leu Leu Glu Glu Ala Ala Asp Leu Leu Leu Ser 
    770                 775                 780                 


Cys Asn Asp Gln Tyr Glu Arg Ala Arg Val Leu Ala Asp Leu Ser Glu 
785                 790                 795                 800 


Ala Phe Ser Ala Leu Arg His His Ser Arg Ala Arg Gly Leu Leu Arg 
                805                 810                 815     


Gln Ala Arg His Leu Ala Ala Gln Cys Gly Ala Thr Pro Leu Leu Arg 
            820                 825                 830         


Arg Leu Gly Ala Lys Pro Gly Gly Pro Gly Trp Leu Glu Glu Ser Gly 
        835                 840                 845             


Leu Pro Gln Arg Ile Lys Ser Leu Thr Asp Ala Glu Arg Arg Val Ala 
    850                 855                 860                 


Ser Leu Ala Ala Gly Gly Gln Thr Asn Arg Val Ile Ala Asp Gln Leu 
865                 870                 875                 880 


Phe Val Thr Ala Ser Thr Val Glu Gln His Leu Thr Asn Val Phe Arg 
                885                 890                 895     


Lys Leu Gly Val Lys Gly Arg Gln His Leu Pro Ala Glu Leu Ala Asn 
            900                 905                 910         


Ala Glu 
        


<210>  32
<211>  875
<212>  PRT
<213>  Actinoplanes sp. N01-109

<400>  32

Met Pro Ala Val Lys Arg Asn Asp Leu Val Ala Arg Asp Gly Glu Leu 
1               5                   10                  15      


Arg Trp Met Gln Glu Ile Leu Ser Gln Ala Ser Glu Gly Arg Gly Ala 
            20                  25                  30          


Val Val Thr Ile Thr Gly Ala Ile Ala Cys Gly Lys Thr Val Leu Leu 
        35                  40                  45              


Asp Ala Ala Ala Ala Ser Gln Asp Val Ile Gln Leu Arg Ala Val Cys 
    50                  55                  60                  


Ser Ala Glu Glu Gln Glu Leu Pro Tyr Ala Met Val Gly Gln Leu Leu 
65                  70                  75                  80  


Asp Asn Pro Val Leu Ala Ala Arg Val Pro Ala Leu Gly Asn Leu Ala 
                85                  90                  95      


Ala Ala Gly Glu Arg Leu Leu Pro Gly Thr Glu Asn Arg Ile Arg Arg 
            100                 105                 110         


Glu Leu Thr Arg Thr Leu Leu Ala Leu Ala Asp Glu Arg Pro Val Leu 
        115                 120                 125             


Ile Gly Val Asp Asp Met His His Ala Asp Pro Ala Ser Leu Asp Cys 
    130                 135                 140                 


Leu Leu His Leu Ala Arg Arg Val Gly Pro Ala Arg Ile Ala Ile Val 
145                 150                 155                 160 


Leu Thr Glu Leu Arg Arg Leu Thr Pro Ala His Ser Arg Phe Gln Ser 
                165                 170                 175     


Glu Leu Leu Ser Leu Arg Tyr His His Glu Ile Gly Leu Gln Pro Leu 
            180                 185                 190         


Thr Ala Glu His Thr Ala Asp Leu Ala Arg Val Gly Leu Gly Ala Glu 
        195                 200                 205             


Val Asp Asp Asp Val Leu Thr Glu Leu Tyr Glu Ala Thr Gly Gly Asn 
    210                 215                 220                 


Pro Ser Leu Cys Cys Gly Leu Ile Arg Asp Val Arg Gln Asp Trp Glu 
225                 230                 235                 240 


Ala Gly Val Thr Gly Ile His Val Gly Arg Ala Tyr Arg Leu Ala Tyr 
                245                 250                 255     


Leu Ser Ser Leu Tyr Arg Cys Gly Pro Ala Ala Leu Arg Thr Ala Arg 
            260                 265                 270         


Ala Ala Ala Val Leu Gly Asp Ser Ala Asp Ala Cys Leu Ile Arg Arg 
        275                 280                 285             


Val Ser Gly Leu Gly Thr Glu Ala Val Gly Gln Ala Ile Gln Gln Leu 
    290                 295                 300                 


Thr Glu Gly Gly Leu Leu Arg Asp Gln Gln Phe Pro His Pro Ala Ala 
305                 310                 315                 320 


Arg Ser Val Val Leu Asp Asp Met Ser Ala Gln Glu Arg His Ala Met 
                325                 330                 335     


Tyr Arg Ser Ala Arg Glu Ala Ala Ala Glu Gly Gln Ala Asp Pro Gly 
            340                 345                 350         


Thr Pro Gly Glu Pro Arg Ala Ala Thr Ala Tyr Ala Gly Cys Gly Glu 
        355                 360                 365             


Gln Ala Gly Asp Tyr Pro Glu Pro Ala Gly Arg Ala Cys Val Asp Gly 
    370                 375                 380                 


Ala Gly Pro Ala Glu Tyr Cys Gly Asp Pro His Gly Ala Asp Asp Asp 
385                 390                 395                 400 


Pro Asp Glu Leu Val Ala Ala Leu Gly Gly Leu Leu Pro Ser Arg Leu 
                405                 410                 415     


Val Ala Met Lys Ile Arg Arg Leu Ala Val Ala Gly Arg Pro Gly Ala 
            420                 425                 430         


Ala Ala Glu Leu Leu Thr Ser Gln Arg Leu His Ala Val Thr Ser Glu 
        435                 440                 445             


Asp Arg Ala Ser Leu Arg Ala Ala Glu Val Ala Leu Ala Thr Leu Trp 
    450                 455                 460                 


Pro Gly Ala Thr Gly Pro Asp Arg His Pro Leu Thr Glu Gln Glu Ala 
465                 470                 475                 480 


Ala Ser Leu Pro Glu Gly Pro Arg Leu Leu Ala Ala Ala Asp Asp Ala 
                485                 490                 495     


Val Gly Ala Ala Leu Arg Gly Arg Ala Glu Tyr Ala Ala Ala Glu Ala 
            500                 505                 510         


Glu Asn Val Leu Arg His Ala Asp Pro Ala Ala Gly Gly Asp Ala Tyr 
        515                 520                 525             


Ala Ala Met Ile Ala Leu Leu Tyr Thr Glu His Pro Glu Asn Val Leu 
    530                 535                 540                 


Phe Trp Ala Asp Lys Leu Asp Ala Gly Arg Pro Asp Glu Glu Thr Ser 
545                 550                 555                 560 


Tyr Pro Gly Leu Arg Ala Glu Thr Ala Val Arg Leu Gly Asp Leu Glu 
                565                 570                 575     


Thr Ala Met Glu Leu Gly Arg Thr Val Leu Asp Gln Arg Arg Leu Pro 
            580                 585                 590         


Ser Leu Gly Val Ala Ala Gly Leu Leu Leu Gly Gly Ala Val Thr Ala 
        595                 600                 605             


Ala Ile Arg Leu Gly Asp Leu Asp Arg Ala Glu Lys Trp Leu Ala Glu 
    610                 615                 620                 


Pro Ile Pro Asp Ala Ile Arg Thr Ser Leu Tyr Gly Leu His Val Leu 
625                 630                 635                 640 


Ala Ala Arg Gly Arg Leu Asp Leu Ala Ala Gly Arg Tyr Glu Ala Ala 
                645                 650                 655     


Tyr Thr Ala Phe Arg Leu Cys Gly Glu Arg Met Ala Gly Trp Asp Ala 
            660                 665                 670         


Asp Val Ser Gly Leu Ala Leu Trp Arg Val Asp Ala Ala Glu Ala Leu 
        675                 680                 685             


Leu Ser Ala Gly Ile Arg Pro Asp Glu Gly Arg Lys Leu Ile Asp Asp 
    690                 695                 700                 


Gln Leu Thr Arg Glu Met Gly Ala Arg Ser Arg Ala Leu Thr Leu Arg 
705                 710                 715                 720 


Ala Gln Ala Ala Tyr Ser Leu Pro Val His Arg Val Gly Leu Leu Asp 
                725                 730                 735     


Glu Ala Ala Gly Leu Leu Leu Ala Cys His Asp Gly Tyr Glu Arg Ala 
            740                 745                 750         


Arg Val Leu Ala Asp Leu Gly Glu Thr Leu Arg Thr Leu Arg His Thr 
        755                 760                 765             


Asp Ala Ala Gln Arg Val Leu Arg Gln Ala Glu Gln Ala Ala Ala Arg 
    770                 775                 780                 


Cys Gly Ser Val Pro Leu Leu Arg Arg Leu Gly Ala Glu Pro Val Arg 
785                 790                 795                 800 


Ile Gly Thr Arg Arg Gly Glu Pro Gly Leu Pro Gln Arg Ile Arg Leu 
                805                 810                 815     


Leu Thr Asp Ala Glu Arg Arg Val Ala Ala Met Ala Ala Ala Gly Gln 
            820                 825                 830         


Thr Asn Arg Glu Ile Ala Gly Arg Leu Phe Val Thr Ala Ser Thr Val 
        835                 840                 845             


Glu Gln His Leu Thr Ser Val Phe Arg Lys Leu Gly Val Lys Gly Arg 
    850                 855                 860                 


Arg Phe Leu Pro Thr Glu Leu Ala Gln Ala Val 
865                 870                 875 


<210>  33
<211>  906
<212>  PRT
<213>  Streptomyces malaysiensis

<400>  33

Met Tyr Ser Gly Thr Cys Arg Glu Gly Tyr Glu Leu Val Ala Arg Glu 
1               5                   10                  15      


Asp Glu Leu Gly Ile Leu Gln Arg Ser Leu Glu Gln Ala Ser Ser Gly 
            20                  25                  30          


Gln Gly Val Val Val Thr Val Thr Gly Pro Ile Ala Cys Gly Lys Thr 
        35                  40                  45              


Glu Leu Leu Asp Ala Ala Ala Ala Lys Ala Glu Ala Ile Ile Leu Arg 
    50                  55                  60                  


Ala Val Cys Ala Pro Glu Glu Arg Ala Met Pro Tyr Ala Met Ile Gly 
65                  70                  75                  80  


Gln Leu Ile Asp Asp Pro Ala Leu Ala His Arg Ala Pro Gly Leu Ala 
                85                  90                  95      


Asp Arg Ile Ala Gln Gly Gly Gln Leu Ser Leu Arg Ala Glu Asn Arg 
            100                 105                 110         


Leu Arg Arg Asp Leu Thr Arg Ala Leu Leu Ala Leu Ala Val Asp Arg 
        115                 120                 125             


Pro Val Leu Ile Gly Val Asp Asp Val His His Ala Asp Thr Ala Ser 
    130                 135                 140                 


Leu Asn Cys Leu Leu His Leu Ala Arg Arg Val Arg Pro Ala Arg Ile 
145                 150                 155                 160 


Ser Met Ile Phe Thr Glu Leu Arg Ser Leu Thr Pro Thr Gln Ser Arg 
                165                 170                 175     


Phe Lys Ala Glu Leu Leu Ser Leu Pro Tyr His His Glu Ile Ala Leu 
            180                 185                 190         


Arg Pro Phe Gly Pro Glu Gln Ser Ala Glu Leu Ala Arg Ala Ala Phe 
        195                 200                 205             


Gly Pro Gly Leu Ala Glu Asp Val Leu Ala Gly Leu Tyr Lys Thr Thr 
    210                 215                 220                 


Arg Gly Asn Leu Ser Leu Ser Arg Gly Leu Ile Ser Asp Val Arg Glu 
225                 230                 235                 240 


Ala Leu Ala Asn Gly Glu Ser Ala Phe Glu Ala Gly Arg Ala Phe Arg 
                245                 250                 255     


Leu Ala Tyr Leu Ser Ser Leu Tyr Arg Cys Gly Pro Val Ala Leu Arg 
            260                 265                 270         


Val Ala Arg Val Ala Ala Val Leu Gly Pro Ser Ala Thr Thr Thr Leu 
        275                 280                 285             


Val Arg Arg Leu Ser Gly Leu Ser Ala Glu Thr Ile Asp Arg Ala Thr 
    290                 295                 300                 


Lys Ile Leu Thr Glu Gly Gly Leu Leu Leu Asp Gln Gln Phe Pro His 
305                 310                 315                 320 


Pro Ala Ala Arg Ser Val Val Leu Asp Asp Met Ser Ala Gln Glu Arg 
                325                 330                 335     


Arg Ser Leu His Thr Leu Ala Leu Glu Leu Leu Asp Glu Ala Pro Val 
            340                 345                 350         


Glu Val Leu Ala His His Gln Val Gly Ala Gly Leu Ile His Gly Pro 
        355                 360                 365             


Lys Ala Ala Glu Met Phe Ala Lys Ala Gly Lys Ala Leu Val Val Arg 
    370                 375                 380                 


Asn Glu Leu Gly Asp Ala Ala Glu Tyr Leu Gln Leu Ala His Arg Ala 
385                 390                 395                 400 


Ser Asp Asp Val Ser Thr Arg Ala Ala Leu Arg Val Glu Ala Val Ala 
                405                 410                 415     


Ile Glu Arg Arg Arg Asn Pro Leu Ala Ser Ser Arg His Met Asp Glu 
            420                 425                 430         


Leu Ser Ala Ala Gly Arg Ala Gly Leu Leu Ser Pro Lys His Ala Ala 
        435                 440                 445             


Leu Ala Val Phe Trp Leu Ala Asp Gly Gly Arg Ser Gly Glu Ala Ala 
    450                 455                 460                 


Glu Val Leu Ala Ser Glu Arg Pro Leu Ala Thr Thr Asp Gln Asn Arg 
465                 470                 475                 480 


Ala His Leu Arg Phe Val Glu Val Thr Leu Ala Leu Phe Ser Pro Gly 
                485                 490                 495     


Ala Phe Gly Ser Asp Arg Arg Pro Pro Pro Leu Thr Pro Asp Glu Leu 
            500                 505                 510         


Ala Ser Leu Pro Lys Ala Ala Trp Gln Cys Ala Val Ala Asp Asn Ala 
        515                 520                 525             


Ala Met Thr Ala Leu His Gly His Pro Glu Leu Ala Thr Ala Gln Ala 
    530                 535                 540                 


Glu Thr Val Leu Arg Gln Ala Asp Ser Ala Ala Asp Ala Ile Pro Ala 
545                 550                 555                 560 


Ala Leu Ile Ala Leu Leu Tyr Ala Glu Asn Thr Glu Ser Ala His Ile 
                565                 570                 575     


Trp Ala Asp Lys Leu Gly Ser Thr Asn Ala Gly Val Ser Asn Glu Ala 
            580                 585                 590         


Glu Ala Gly Tyr Ala Gly Pro Cys Ala Glu Ile Ala Leu Arg Arg Gly 
        595                 600                 605             


Asp Leu Ala Thr Ala Phe Glu Ala Gly Ser Ala Val Leu Asp Asp Arg 
    610                 615                 620                 


Ser Leu Pro Ser Leu Gly Ile Thr Ala Ala Leu Leu Leu Ser Ser Lys 
625                 630                 635                 640 


Thr Ala Ala Ala Val Arg Leu Gly Glu Leu Glu Arg Ala Glu Lys Leu 
                645                 650                 655     


Leu Ala Glu Pro Leu Pro Asn Gly Val Gln Asp Ser Leu Phe Gly Leu 
            660                 665                 670         


His Leu Leu Ser Ala Tyr Gly Gln Tyr Ser Leu Ala Met Gly Arg Tyr 
        675                 680                 685             


Glu Ser Ala His Arg Ala Phe Arg Thr Cys Gly Glu Arg Met Arg Ser 
    690                 695                 700                 


Trp Asp Val Asp Val Pro Gly Leu Ala Leu Trp Arg Val Asp Ala Ala 
705                 710                 715                 720 


Glu Ala Leu Leu Ser Leu Asp Arg Asn Glu Gly Gln Arg Leu Ile Asp 
                725                 730                 735     


Glu Gln Leu Thr Arg Pro Met Gly Pro Arg Ser His Ala Leu Thr Leu 
            740                 745                 750         


Arg Ile Lys Ala Ala Tyr Leu Pro Arg Thr Lys Arg Ile Pro Leu Leu 
        755                 760                 765             


His Glu Ala Ala Glu Leu Leu Leu Pro Cys Pro Asp Pro Tyr Glu Gln 
    770                 775                 780                 


Ala Arg Val Leu Ala Asp Leu Gly Asp Thr Leu Ser Ala Leu Arg Arg 
785                 790                 795                 800 


Tyr Ser Arg Ala Arg Gly Val Leu Arg Gln Ala Arg His Leu Ala Thr 
                805                 810                 815     


Gln Cys Gly Ala Val Pro Leu Leu Arg Arg Leu Gly Gly Glu Pro Gly 
            820                 825                 830         


Arg Ile Asp Asp Ala Gly Leu Pro Gln Arg Ser Thr Ser Leu Thr Asp 
        835                 840                 845             


Ala Glu Arg Arg Val Ala Ala Leu Ala Ala Ala Gly Gln Thr Asn Arg 
    850                 855                 860                 


Glu Ile Ala Glu Gln Leu Phe Val Thr Ala Ser Thr Val Glu Gln His 
865                 870                 875                 880 


Leu Thr Ser Val Phe Arg Lys Leu Gly Val Lys Gly Arg Lys Gln Leu 
                885                 890                 895     


Pro Thr Ala Leu Ala Asp Val Glu Gln Thr 
            900                 905     


<210>  34
<211>  904
<212>  PRT
<213>  Streptomyces violaceusniger

<400>  34

Met Tyr Ser Gly Thr Cys Arg Glu Gly Tyr Glu Leu Val Ala Arg Glu 
1               5                   10                  15      


Asp Glu Leu Gly Ile Leu Gln Arg Ser Leu Glu Glu Ala Gly Ser Gly 
            20                  25                  30          


Gln Gly Ala Val Val Thr Val Thr Gly Pro Ile Ala Cys Gly Lys Thr 
        35                  40                  45              


Glu Leu Leu Asp Ala Ala Ala Ala Lys Ala Asp Ala Ile Ile Leu Arg 
    50                  55                  60                  


Ala Val Cys Ala Pro Glu Glu Arg Ala Met Pro Tyr Ala Met Ile Gly 
65                  70                  75                  80  


Gln Leu Ile Asp Asp Pro Ala Leu Ala His Arg Ala Pro Glu Leu Ala 
                85                  90                  95      


Asp Arg Ile Ala Gln Gly Gly His Leu Ser Leu Arg Ala Glu Asn Arg 
            100                 105                 110         


Leu Arg Arg Asp Leu Thr Arg Ala Leu Leu Ala Leu Ala Val Asp Arg 
        115                 120                 125             


Pro Val Leu Ile Gly Val Asp Asp Val His His Ala Asp Thr Ala Ser 
    130                 135                 140                 


Leu Asn Cys Leu Leu His Leu Ala Arg Arg Val Arg Pro Ala Arg Ile 
145                 150                 155                 160 


Ser Met Ile Phe Thr Glu Leu Arg Ser Leu Thr Pro Thr Gln Ser Arg 
                165                 170                 175     


Phe Lys Ala Glu Leu Leu Ser Leu Pro Tyr His His Glu Ile Ala Leu 
            180                 185                 190         


Arg Pro Leu Gly Pro Glu Gln Ser Ala Glu Leu Ala His Ala Ala Phe 
        195                 200                 205             


Gly Pro Gly Leu Ala Glu Asp Val Leu Ala Gly Leu Tyr Gly Met Thr 
    210                 215                 220                 


Arg Gly Asn Leu Ser Leu Ser Arg Gly Leu Ile Ser Asp Val Arg Glu 
225                 230                 235                 240 


Ala Gln Ala Asn Gly Glu Ser Ala Phe Glu Val Gly Arg Ala Phe Arg 
                245                 250                 255     


Leu Ala Tyr Leu Ser Ser Leu Tyr Arg Cys Gly Pro Ile Ala Leu Arg 
            260                 265                 270         


Val Ala Arg Val Ala Ala Val Leu Gly Pro Ser Ala Thr Thr Thr Leu 
        275                 280                 285             


Val Arg Arg Leu Ser Gly Leu Ser Ala Glu Thr Ile Asp Arg Ala Thr 
    290                 295                 300                 


Lys Ile Leu Thr Glu Gly Gly Leu Leu Leu Asp His Gln Phe Pro His 
305                 310                 315                 320 


Pro Ala Ala Arg Ser Val Val Leu Asp Asp Met Ser Ala Gln Glu Arg 
                325                 330                 335     


Arg Ser Leu His Thr Leu Ala Leu Glu Leu Leu Asp Glu Ala Pro Val 
            340                 345                 350         


Glu Val Leu Ala His His Gln Val Gly Ala Gly Leu Ile His Gly Pro 
        355                 360                 365             


Lys Ala Ala Glu Ile Phe Ala Arg Ala Gly Gln Ala Leu Val Val Arg 
    370                 375                 380                 


Asn Glu Leu Gly Asp Ala Ala Glu Tyr Leu Gln Leu Ala His Arg Ala 
385                 390                 395                 400 


Ser Asp Asp Val Ser Thr Arg Ala Ala Leu Arg Val Glu Ala Val Ala 
                405                 410                 415     


Ile Glu Arg Arg Arg Asn Pro Leu Ala Ser Ser Arg His Met Asp Glu 
            420                 425                 430         


Leu Ser Ala Ala Gly Arg Ala Gly Leu Leu Ser Pro Lys His Ala Ala 
        435                 440                 445             


Leu Ala Val Phe Trp Leu Ala Asp Gly Gly Arg Ser Gly Glu Ala Ala 
    450                 455                 460                 


Glu Val Leu Ala Ser Glu His Pro Leu Ala Thr Thr Asp Gln Asn Arg 
465                 470                 475                 480 


Ala His Leu Arg Phe Ala Glu Val Thr Leu Ala Leu Phe Cys Pro Gly 
                485                 490                 495     


Ala Phe Gly Ser Asp Arg Arg Pro Pro Pro Leu Ala Pro Asp Glu Leu 
            500                 505                 510         


Ala Ser Leu Pro Lys Ala Ala Trp Gln Cys Ala Val Ala Asp Asn Ala 
        515                 520                 525             


Val Met Thr Ala Leu His Ala His Pro Glu Leu Ala Thr Ala Gln Ala 
    530                 535                 540                 


Glu Thr Val Leu Arg Gln Ala Asp Ser Ala Ala Asp Ala Ile Pro Ala 
545                 550                 555                 560 


Ala Leu Ile Ala Leu Leu Tyr Ala Glu Asn Thr Glu Ser Ala Gln Ile 
                565                 570                 575     


Trp Ala Asp Lys Leu Gly Ser Thr Asn Ala Gly Val Ser Asn Glu Ala 
            580                 585                 590         


Glu Ala Gly Tyr Ala Gly Pro Cys Ala Glu Ile Ala Leu Arg Arg Gly 
        595                 600                 605             


Asp Leu Ala Thr Ala Phe Glu Ala Gly Gly Thr Val Leu Asp Asp Arg 
    610                 615                 620                 


Pro Leu Pro Ser Leu Gly Ile Thr Ala Ala Leu Leu Leu Ser Ser Lys 
625                 630                 635                 640 


Thr Ala Ala Ala Val Arg Leu Gly Glu Leu Glu Arg Ala Glu Lys Leu 
                645                 650                 655     


Leu Ala Glu Pro Leu Pro Asn Gly Val Gln Asp Ser Leu Phe Gly Leu 
            660                 665                 670         


His Leu Leu Ser Ala His Gly Gln Tyr Ser Leu Ala Met Gly Arg Tyr 
        675                 680                 685             


Glu Ser Ala His Arg Ala Phe His Thr Cys Gly Glu Arg Met Arg Ser 
    690                 695                 700                 


Trp Gly Val Asp Val Pro Gly Leu Ala Leu Trp Arg Val Asp Ala Ala 
705                 710                 715                 720 


Glu Ala Leu Leu Ser Leu Asp Arg Asn Glu Gly Gln Arg Leu Ile Asp 
                725                 730                 735     


Glu Gln Leu Ala Arg Pro Met Gly Pro Arg Ser Arg Ala Leu Thr Leu 
            740                 745                 750         


Arg Ile Lys Ala Ala Tyr Leu Pro Arg Thr Lys Arg Ile Pro Leu Leu 
        755                 760                 765             


His Glu Ala Ala Glu Leu Leu Leu Ser Cys Pro Asp Pro Tyr Glu Gln 
    770                 775                 780                 


Ala Arg Val Leu Ala Asp Leu Gly Asp Thr Leu Ser Ala Leu Arg Arg 
785                 790                 795                 800 


Tyr Ser Arg Ala Arg Gly Val Leu Arg Gln Ala Arg His Leu Ala Thr 
                805                 810                 815     


Gln Cys Gly Ala Val Pro Leu Leu Arg Arg Leu Gly Gly Glu Pro Gly 
            820                 825                 830         


Arg Ile Asp Asp Ala Gly Leu Pro Gln Arg Ser Thr Ser Leu Thr Asp 
        835                 840                 845             


Ala Glu Arg Arg Val Ser Ala Leu Ala Ala Ala Gly Gln Thr Asn Arg 
    850                 855                 860                 


Glu Ile Ala Lys Gln Leu Phe Val Thr Ala Ser Thr Val Glu Gln His 
865                 870                 875                 880 


Leu Thr Ser Val Phe Arg Lys Leu Gly Val Lys Gly Arg Arg Gln Leu 
                885                 890                 895     


Pro Thr Ala Leu Ala Asp Val Glu 
            900                 


<210>  35
<211>  906
<212>  PRT
<213>  Streptomyces Sp. NRRL F-4729

<400>  35

Met Tyr Ser Gly Thr Cys Arg Glu Gly Tyr Glu Leu Val Ala Arg Glu 
1               5                   10                  15      


Asp Glu Leu Gly Ile Leu Gln Arg Ser Leu Glu Gln Ala Ser Ser Gly 
            20                  25                  30          


Gln Gly Val Val Val Thr Val Thr Gly Pro Ile Ala Cys Gly Lys Thr 
        35                  40                  45              


Glu Leu Leu Asp Ala Ala Ala Ala Lys Ala Glu Ala Ile Ile Leu Arg 
    50                  55                  60                  


Ala Val Cys Ala Pro Glu Glu Arg Ala Met Pro Tyr Ala Met Ile Gly 
65                  70                  75                  80  


Gln Leu Ile Asp Asp Pro Ala Leu Ala His Arg Ala Pro Gly Leu Ala 
                85                  90                  95      


Asp Arg Ile Ala Gln Gly Gly Gln Leu Ser Leu Arg Ala Glu Asn Arg 
            100                 105                 110         


Leu Arg Arg Asp Leu Thr Arg Ala Leu Leu Ala Leu Ala Val His Arg 
        115                 120                 125             


Pro Val Leu Ile Gly Val Asp Asp Val His His Ala Asp Thr Ala Ser 
    130                 135                 140                 


Leu Asn Cys Leu Leu His Leu Ala Arg Arg Val Arg Pro Ala Arg Ile 
145                 150                 155                 160 


Ser Met Ile Phe Thr Glu Leu Arg Ser Leu Thr Pro Thr Gln Ser Arg 
                165                 170                 175     


Phe Lys Ala Glu Leu Leu Ser Leu Pro Tyr His His Glu Ile Ala Leu 
            180                 185                 190         


Arg Pro Phe Gly Pro Glu Gln Ser Ala Glu Leu Ala Arg Ala Ala Phe 
        195                 200                 205             


Gly Pro Gly Leu Ala Glu Asp Val Leu Ala Gly Leu Tyr Lys Thr Thr 
    210                 215                 220                 


Arg Gly Asn Leu Ser Leu Ser Arg Gly Leu Ile Ser Asp Val Arg Glu 
225                 230                 235                 240 


Ala Leu Ala Asn Gly Glu Ser Ala Phe Glu Ala Gly Arg Ala Phe Arg 
                245                 250                 255     


Leu Ala Tyr Leu Ser Ser Leu Tyr Arg Cys Gly Pro Val Ala Leu Arg 
            260                 265                 270         


Val Ala Arg Val Ala Ala Val Leu Gly Pro Ser Ala Thr Thr Thr Leu 
        275                 280                 285             


Val Arg Arg Leu Ser Gly Leu Ser Ala Glu Thr Ile Asp Arg Ala Thr 
    290                 295                 300                 


Lys Ile Leu Thr Glu Gly Gly Leu Leu Leu Asp Gln Gln Phe Pro His 
305                 310                 315                 320 


Pro Ala Ala Arg Ser Val Val Leu Asp Asp Met Ser Ala Gln Glu Arg 
                325                 330                 335     


Arg Gly Leu His Thr Leu Ala Leu Glu Leu Leu Asp Glu Ala Pro Val 
            340                 345                 350         


Glu Val Leu Ala His His Gln Val Gly Ala Gly Leu Ile His Gly Pro 
        355                 360                 365             


Lys Ala Ala Glu Met Phe Ala Lys Ala Gly Lys Ala Leu Val Val Arg 
    370                 375                 380                 


Asn Glu Leu Gly Asp Ala Ala Glu Tyr Leu Gln Leu Ala His Arg Ala 
385                 390                 395                 400 


Ser Asp Asp Val Ser Thr Arg Ala Ala Leu Arg Val Glu Ala Val Ala 
                405                 410                 415     


Ile Glu Arg Arg Arg Asn Pro Leu Ala Ser Ser Arg His Met Asp Glu 
            420                 425                 430         


Leu Ser Ala Ala Gly Arg Ala Gly Leu Leu Ser Pro Lys His Ala Ala 
        435                 440                 445             


Leu Ala Val Phe Trp Leu Ala Asp Gly Gly Arg Ser Gly Glu Ala Ala 
    450                 455                 460                 


Gln Val Leu Ala Ser Glu Arg Pro Leu Ala Thr Thr Asp Gln Asn Arg 
465                 470                 475                 480 


Ala His Leu Arg Phe Val Glu Val Thr Leu Ala Leu Phe Ser Pro Gly 
                485                 490                 495     


Ala Phe Gly Ser Asp Arg Arg Pro Pro Pro Leu Thr Pro Asp Glu Leu 
            500                 505                 510         


Ala Ser Leu Pro Lys Ala Ala Trp Gln Cys Ala Val Ala Asp Asn Ala 
        515                 520                 525             


Ala Met Thr Ala Leu His Gly His Pro Glu Leu Ala Thr Ala Gln Ala 
    530                 535                 540                 


Glu Thr Val Leu Arg Gln Ala Asp Ser Ala Ala Asp Ala Ile Pro Ala 
545                 550                 555                 560 


Ala Leu Ile Ala Leu Leu Tyr Ala Glu Asn Thr Glu Ser Ala His Ile 
                565                 570                 575     


Trp Ala Asp Lys Leu Gly Ser Met Asn Ala Gly Val Ser Asn Glu Ala 
            580                 585                 590         


Glu Ala Gly Tyr Ala Gly Pro Cys Ala Glu Ile Ala Leu Arg Arg Gly 
        595                 600                 605             


Asp Leu Ala Thr Ala Phe Glu Ala Gly Ser Thr Val Leu Asp Asp Arg 
    610                 615                 620                 


Ser Leu Pro Ser Leu Gly Ile Thr Ala Ala Leu Leu Leu Ser Ser Lys 
625                 630                 635                 640 


Thr Ala Ala Ala Val Arg Leu Gly Glu Leu Glu Arg Ala Glu Lys Leu 
                645                 650                 655     


Leu Ala Glu Pro Leu Pro Asn Gly Val Gln Asp Ser Leu Phe Gly Leu 
            660                 665                 670         


His Leu Leu Ser Ala Tyr Gly Gln Tyr Ser Leu Ala Met Gly Arg Tyr 
        675                 680                 685             


Glu Ser Ala His Arg Ala Phe Arg Thr Cys Gly Glu Arg Met Arg Ser 
    690                 695                 700                 


Trp Asp Val Asp Val Pro Gly Leu Ala Leu Trp Arg Val Asp Ala Ala 
705                 710                 715                 720 


Glu Ala Leu Leu Ser Leu Asp Arg Asn Glu Gly Gln Arg Leu Ile Asp 
                725                 730                 735     


Glu Gln Leu Thr Arg Pro Met Gly Pro Arg Ser Arg Ala Leu Thr Leu 
            740                 745                 750         


Arg Ile Lys Ala Ala Tyr Leu Pro Arg Thr Lys Arg Ile Pro Leu Leu 
        755                 760                 765             


His Glu Ala Ala Glu Leu Leu Leu Pro Cys Pro Asp Pro Tyr Glu Gln 
    770                 775                 780                 


Ala Arg Val Leu Ala Asp Leu Gly Asp Thr Leu Ser Ala Leu Arg Arg 
785                 790                 795                 800 


Tyr Ser Arg Ala Arg Gly Val Leu Arg Gln Ala Arg His Leu Ala Thr 
                805                 810                 815     


Gln Cys Gly Ala Val Pro Leu Leu Arg Arg Leu Gly Gly Glu Pro Gly 
            820                 825                 830         


Arg Ile Asp Asp Ala Gly Leu Pro Gln Arg Ser Thr Ser Leu Thr Asp 
        835                 840                 845             


Ala Glu Arg Arg Val Ala Ala Leu Ala Ala Ala Gly Gln Thr Asn Arg 
    850                 855                 860                 


Glu Ile Ala Glu Gln Leu Phe Val Thr Ala Ser Thr Val Glu Gln His 
865                 870                 875                 880 


Leu Thr Ser Val Phe Arg Lys Leu Gly Val Lys Gly Arg Lys Gln Leu 
                885                 890                 895     


Pro Thr Ala Leu Ala Asp Val Glu Gln Thr 
            900                 905     


<210>  36
<211>  904
<212>  PRT
<213>  Streptomyces filamentosus

<400>  36

Met Arg Ala Ile Asn Ala Ser Asp Thr Gly Pro Glu Leu Val Ala Arg 
1               5                   10                  15      


Glu Asp Glu Leu Gly Arg Val Arg Ser Ala Leu Asn Arg Ala Asn Gly 
            20                  25                  30          


Gly Gln Gly Val Leu Ile Ser Ile Thr Gly Pro Ile Ala Cys Gly Lys 
        35                  40                  45              


Thr Glu Leu Leu Glu Ala Ala Ala Ser Glu Val Asp Ala Ile Thr Leu 
    50                  55                  60                  


Arg Ala Val Cys Ala Ala Glu Glu Arg Ala Ile Pro Tyr Ala Leu Ile 
65                  70                  75                  80  


Gly Gln Leu Ile Asp Asn Pro Ala Leu Gly Ile Pro Val Pro Asp Pro 
                85                  90                  95      


Ala Gly Leu Thr Ala Gln Gly Gly Arg Leu Ser Ser Ser Ala Glu Asn 
            100                 105                 110         


Arg Leu Arg Arg Asp Leu Thr Arg Ala Leu Leu Thr Leu Ala Thr Asp 
        115                 120                 125             


Arg Leu Val Leu Ile Cys Val Asp Asp Val Gln His Ala Asp Asn Ala 
    130                 135                 140                 


Ser Leu Ser Cys Leu Leu Tyr Leu Ala Arg Arg Leu Val Pro Ala Arg 
145                 150                 155                 160 


Ile Ala Leu Val Phe Thr Glu Leu Arg Val Leu Thr Ser Ser Gln Leu 
                165                 170                 175     


Arg Phe Asn Ala Glu Leu Leu Ser Leu Arg Asn His Cys Glu Ile Ala 
            180                 185                 190         


Leu Arg Pro Leu Gly Pro Gly His Ala Ala Glu Leu Ala Arg Ala Thr 
        195                 200                 205             


Leu Gly Pro Gly Leu Ser Asp Glu Thr Leu Thr Glu Leu Tyr Arg Val 
    210                 215                 220                 


Thr Gly Gly Asn Leu Ser Leu Ser Arg Gly Leu Ile Asp Asp Val Arg 
225                 230                 235                 240 


Asp Ala Trp Ala Arg Gly Glu Thr Gly Val Gln Val Gly Arg Ala Phe 
                245                 250                 255     


Arg Leu Ala Tyr Leu Gly Ser Leu His Arg Cys Gly Pro Leu Ala Leu 
            260                 265                 270         


Arg Val Ala Arg Val Ala Ala Val Leu Gly Pro Ser Ala Thr Ser Val 
        275                 280                 285             


Leu Val Arg Arg Ile Ser Gly Leu Ser Ala Glu Ala Met Ala Gln Ala 
    290                 295                 300                 


Thr Asp Ile Leu Ala Asp Gly Gly Leu Leu Arg Asp Gln Arg Phe Thr 
305                 310                 315                 320 


His Pro Ala Ala Arg Ser Val Val Leu Asp Asp Met Ser Ala Glu Glu 
                325                 330                 335     


Arg Arg Ser Val His Ser Leu Ala Leu Glu Leu Leu Asp Glu Ala Pro 
            340                 345                 350         


Ala Glu Met Leu Ala His His Arg Val Gly Ala Gly Leu Val His Gly 
        355                 360                 365             


Pro Lys Ala Ala Glu Thr Phe Thr Gly Ala Gly Arg Ala Leu Ala Val 
    370                 375                 380                 


Arg Gly Met Leu Gly Glu Ala Ala Asp Tyr Leu Gln Leu Ala Tyr Arg 
385                 390                 395                 400 


Ala Ser Gly Asp Ala Ala Thr Lys Ala Ala Ile Arg Val Glu Ser Val 
                405                 410                 415     


Ala Val Glu Arg Arg Arg Asn Pro Leu Val Val Ser Arg His Trp Asp 
            420                 425                 430         


Glu Leu Ser Val Ala Ala Arg Ala Gly Leu Leu Ser Cys Glu His Val 
        435                 440                 445             


Ser Arg Thr Ala Arg Trp Leu Thr Val Gly Gly Arg Pro Gly Glu Ala 
    450                 455                 460                 


Ala Arg Val Leu Ala Ser Gln His Arg Arg Val Val Thr Asp Gln Asp 
465                 470                 475                 480 


Arg Ala His Leu Arg Val Ala Glu Phe Ser Leu Ala Leu Leu Tyr Pro 
                485                 490                 495     


Gly Thr Ser Gly Ser Asp Arg Arg Pro His Pro Leu Thr Ser Asp Glu 
            500                 505                 510         


Leu Ala Ala Leu Pro Thr Ala Thr Arg His Cys Ala Ile Ala Asp Asn 
        515                 520                 525             


Ala Val Met Ala Ala Leu Arg Gly His Pro Glu Leu Ala Thr Ala Glu 
    530                 535                 540                 


Ala Glu Ala Val Leu Gln Gln Ala Asp Ala Ala Asp Gly Ala Ala Leu 
545                 550                 555                 560 


Thr Ala Leu Met Ala Leu Leu Tyr Ala Glu Ser Ile Glu Val Ala Glu 
                565                 570                 575     


Val Trp Ala Asp Lys Leu Ala Ala Glu Ala Gly Ala Ser Asn Gly Gln 
            580                 585                 590         


Asp Ala Glu Tyr Ala Gly Ile Arg Ala Glu Ile Ala Leu Arg Arg Gly 
        595                 600                 605             


Asp Leu Thr Ala Ala Val Glu Thr Ala Gly Met Val Leu Asp Gly Arg 
    610                 615                 620                 


Pro Leu Pro Ser Leu Asp Ile Thr Ala Thr Leu Leu Leu Ala Gly Arg 
625                 630                 635                 640 


Ala Ser Val Ala Val Arg Leu Gly Glu Leu Asp His Ala Glu Glu Leu 
                645                 650                 655     


Phe Ala Ala Pro Pro Glu Asp Ala Phe Gln Asp Ser Leu Phe Gly Leu 
            660                 665                 670         


His Leu Leu Ser Ala His Gly Gln Tyr Ser Leu Ala Thr Gly Arg Pro 
        675                 680                 685             


Glu Ser Ala Tyr Arg Ala Phe Arg Ala Cys Gly Glu Arg Met Arg Asp 
    690                 695                 700                 


Trp Gly Phe Asp Ala Pro Gly Val Ala Leu Trp Arg Val Gly Ala Ala 
705                 710                 715                 720 


Glu Ala Leu Leu Gly Leu Asp Arg Asn Glu Gly Arg Arg Leu Ile Asp 
                725                 730                 735     


Glu Gln Leu Ser Arg Thr Met Ala Pro Arg Ser His Ala Leu Thr Leu 
            740                 745                 750         


Arg Ile Lys Ala Ala Tyr Met Pro Glu Pro Lys Arg Val Asp Leu Leu 
        755                 760                 765             


Tyr Glu Ala Ala Glu Leu Leu Leu Ser Cys Arg Asp Gln Tyr Glu Arg 
    770                 775                 780                 


Ala Arg Val Leu Ala Asp Leu Gly Glu Ala Leu Ser Ala Leu Gly Asn 
785                 790                 795                 800 


Tyr Arg Gln Ala Arg Gly Val Leu Arg Gln Ala Arg His Leu Ala Met 
                805                 810                 815     


Arg Thr Gly Ala Asp Pro Leu Leu Arg Arg Leu Gly Ile Arg Pro Gly 
            820                 825                 830         


Arg Gln Asp Asp Pro Asp Pro Gln Pro Arg Ser Arg Ser Leu Thr Asn 
        835                 840                 845             


Ala Glu Arg Arg Ala Ala Ser Leu Ala Ala Thr Gly Leu Thr Asn Arg 
    850                 855                 860                 


Glu Ile Ala Asp Arg Leu Phe Val Thr Ala Ser Thr Val Glu Gln His 
865                 870                 875                 880 


Leu Thr Asn Val Phe Arg Lys Leu Gly Val Lys Gly Arg Lys Gln Leu 
                885                 890                 895     


Pro Ala Glu Leu Asp Asp Met Glu 
            900                 


<210>  37
<211>  75
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  37
caaagcgatt cggagagcgg ccggatcaga tccaggcgtg acattcatac ccttccggcg       60

aagtgcagtt caccc                                                        75


<210>  38
<211>  73
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  38
cgatcttctc gaaactgcac tgaggaggtt cgtcggagac tgccattcac ctctcccgga       60

aaggtattgc tcg                                                          73


<210>  39
<211>  429
<212>  DNA
<213>  Streptomyces filamentosus

<400>  39
gcgttcggca ttgacgcgaa gcaagtcatg aatcggctga atcaattccg cgcgcgacat       60

tcgcaccctt ccggtgaagt gcggtattgc tcagacataa cccggatcgc aatccaacga      120

ccagccatgc actaccgata atcgaatcgg aacaatagca agctcgttga gcatattttc      180

catgcggcac cacctcggcg ccacccccta gttttgccga ccccctatgt gtatttcggc      240

aggcagacta gggggttgcg tgggccgcac ccgaggcatt cgattggcgc acggcgcact      300

cgggccatgt caccgaccgt gaatgtttca tcgctacggg tagcaatagt cctttctcgg      360

gagaagtgaa tggcttccaa aagtccccgc ccagggtccg agagagcggg ttctgcgatt      420

tcccgggca                                                              429


<210>  40
<211>  433
<212>  DNA
<213>  Streptomyces filamentosus

<400>  40
gcgttcggca ttgacgcgaa gcaagtcatg aatcggctga atcaattccg cgcgcgacat       60

tcgcaccctt ccggtgaagt gcggtattgc tcagacataa cccggatcgc aatccaacga      120

ccagccatgc actaccgata atcgaatcgg aacaatagca agctcgttga gcatattttc      180

catgcggcac cacctcggcg ccacccccta gttttgccga ccccctatgt gtatttcggc      240

aggcagaaca cctagggggt tgcgtgggcc gcacccgagg cattcgattg gcgcacggcg      300

cactcgggcc atgtcaccga ccgtgaatgt ttcatcgcta cgggtagcaa tagtcctttc      360

tcgggagaag tgaatggctt ccaaaagtcc ccgcccaggg tccgagagag cgggttctgc      420

gatttcccgg gca                                                         433


<210>  41
<211>  432
<212>  DNA
<213>  Streptomyces violaceusniger

<400>  41
gcgttcggca ttgacgcgaa gcaagtcatg aatcggctga atcaattccg cgcgcgacat       60

tcgcatcctt ctggtgaggt gcagtattgc tgagacataa tccgggccgt aatccaacga      120

ccagccatgc gccgccgata gtcgaatccg atagtcgaat ctgaacgcta gcagctcgtc      180

gcaggggctc cggggagccc aaccccctaa tttttccgcc cccctataca tatccactgc      240

aggcagaaca cctagggggt tgcgcgaacc gggcgcgcgg tatcggattt accgcacggc      300

acactcgggc gacgtcaccg accgtgaatc cttcatcgct acgggtagca cagtcctttc      360

cgggagaagt gaatggcttc caaaagtccc cgcccagggt ccgagagagc gggttctgcg      420

atttcccggg ca                                                          432


<210>  42
<211>  350
<212>  DNA
<213>  Streptomyces violaceusniger

<400>  42
gcgttcggca ttgacgcgaa gcaagtcatg aatcggctga atcaattccg cgcgcgacat       60

tcataccctt ccggcgaagt gcagttcacc cggtaatgca ttccggaccg tagcagtccg      120

atacagacgt ccgccatgcc gtgccaccct tgtttttcac ccccctacgc ccgtttcgcc      180

tggccggaaa cctagggggt tgcgtggaaa gcaccggcgg gtgttcgctt gcacagcgcc      240

acctcgggca ttttctggat gcgcgagcaa tacctttccg ggagaggtga atggcttcca      300

aaagtccccg cccagggtcc gagagagcgg gttctgcgat ttcccgggca                 350


<210>  43
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  43
gcgcccacct taatcgcagg tgtccacgca accccctagg tttccggcca gg               52


<210>  44
<211>  59
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  44
gttcatagct ctccacggca ggcattcata cccttccggc gaagtgcagt tcacccggt        59


<210>  45
<211>  53
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  45
gcgcccacct taatcgcagg tgccaccctt gtttttcacc cccctacgcc cgt              53


<210>  46
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  46
gttcatagct ctccacggca ggcattcacc tctcccggaa aggtattgct cgtgcatcca       60


<210>  47
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  47
actgcacttc gccggaaggg tatgaatgcc tgccgtggag agctatgaac tggacgc          57


<210>  48
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  48
ccgggagggc catggagacc gga                                               23


<210>  49
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  49
agcaatacct ttccgggaga ggtgaatgcc tgccgtggag agctatgaac tggacgc          57


<210>  50
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  50
ccgggagggc catggagacc gga                                               23


<210>  51
<211>  82
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  51
ctacccgaat acatcgcctt ctggggccca gcccaaacca gcgccctcat ccacactcca       60

cgcaaccccc taggtttccg gc                                                82


<210>  52
<211>  91
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  52
gcggcccaca acgtgcacga gcgtggcgat atcggacgcg gaaagaacca gcgtgctcat       60

tcataccctt ccggcgaagt gcagttcacc c                                      91


<210>  53
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  53
cgccgtctac ccagcccaaa gccagc                                            26


<210>  54
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  54
cgggttcgtg gtgcggcatc cattcg                                            26


<210>  55
<211>  69
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  55
caaagcgatt cggagagcgg ccggatcaga tccaggcgtg acatggcctg gtgatgatgg       60

cgggatcgt                                                               69


<210>  56
<211>  74
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  56
cgatcttctc gaaactgcac tgaggaggtt cgtcggagac tgccattcat cgcagtactg       60

ttgtattcat taag                                                         74


<210>  57
<211>  75
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  57
caaagcgatt cggagagcgg ccggatcaga tccaggcgtg acattcatac ccttccggcg       60

aagtgcagtt caccc                                                        75


<210>  58
<211>  73
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  58
cgatcttctc gaaactgcac tgaggaggtt cgtcggagac tgccattcac ctctcccgga       60

aaggtattgc tcg                                                          73


<210>  59
<211>  98
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  59
gcaaagcgat tcggagagcg gccggatcag atccaggcgt gacatgttta aacacaacgt       60

acctttcgga caagagtgcc gcggtgcaca gcctgacc                               98


<210>  60
<211>  98
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  60
ggtcaggctg tgcaccgcgg cactcttgtc cgaaaggtac gttgtgttta aacatgtcac       60

gcctggatct gatccggccg ctctccgaat cgctttgc                               98


<210>  61
<211>  98
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  61
tccacacctc tcggttcaca aacgtccgag cataagggag gtaaagttta aacatggcag       60

tctccgacga acctcctcag tgcagtttcg agaagatc                               98


<210>  62
<211>  98
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  62
gatcttctcg aaactgcact gaggaggttc gtcggagact gccatgttta aactttacct       60

cccttatgct cggacgtttg tgaaccgaga ggtgtgga                               98


<210>  63
<211>  75
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  63
caaagcgatt cggagagcgg ccggatcaga tccaggcgtg acattcatac ccttccggcg       60

aagtgcagtt caccc                                                        75


<210>  64
<211>  73
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  64
cgatcttctc gaaactgcac tgaggaggtt cgtcggagac tgccattcac ctctcccgga       60

aaggtattgc tcg                                                          73


<210>  65
<211>  87
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  65
cccgaaccac gatgagcact tgcctatgcg gtgtagggat aacagggtaa ttaattaatg       60

acctgcgccc accttaatcg caggtgc                                           87


<210>  66
<211>  98
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  66
tactttctat ttttaattta tatatttata ttaaaaaatt taaaatataa ttatttttat       60

agcacgtgat ggagcctatg gaaaaacgcc agcaacgc                               98


<210>  67
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  67
ggtagtattt gttggcgatc cccctagagt cttttacatc ttcgg                       45


<210>  68
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  68
agcctgcccc tcatctgtca ac                                                22


<210>  69
<211>  99
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  69
gttgatcgtg tggggcggcc tgccgagcag ctggtggacc cctggggcga gctggcgcat       60

tcacctgtat actgagagtg caccataaac gacattact                              99


<210>  70
<211>  94
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  70
gacgaccgcg gtccccacga ggacagcggc cgacgcaaca gctttgcgaa gacgagtcat       60

tcatacgtat acaggcaagt gcacaaacaa tact                                   94


<210>  71
<211>  100
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  71
cgccggtgag gccagaccca tgagggtcag tgctgcgacc accgcgtacc tgatccgcat       60

tcacctgtta actcctgatg cggtattttc tccttacgca                            100


<210>  72
<211>  90
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  72
ctcggccggc agcaaggtct gctcgatcgc gatgatccgg ccgttccccc agtcgatcgt       60

gttaaccgac tacgtcgtaa ggccgtttct                                        90


<210>  73
<211>  102
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  73
gacgaacgcg aagtcgtcgc cgccctcctt catgcccagt ccggtggtcc agccgcggaa       60

gccgtgcgga tgcattcacc tctcccggaa aggtattgct cg                         102


<210>  74
<211>  102
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  74
tcgccacggg cggtcgagga actcgtcgcg gaccgccgcg acccgtgttc gcgcgccgtc       60

accgccgacg cgcattcata cccttccggc gaagtgcagt tc                         102


<210>  75
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  75
ggcgtggctg gagccgaagt ggtc                                              24


<210>  76
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  76
tcttccacta ctgccatctg gcgtcataac tgc                                    33


<210>  77
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  77
aggttattac tgagtagtat ttatttaagt attgtttgtg cacttgcct                   49


<210>  78
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  78
actcggcggc gttggcgtgg c                                                 21


<210>  79
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  79
accgtcgccc cgccgcagc                                                    19


<210>  80
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  80
cgcacagatt cgtaaggaga aaataccgca tcagga                                 36


<210>  81
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  81
actctgtcag aaacggcctt acgacgtagt cg                                     32


<210>  82
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  82
cgggcggcac gcaaccgaag tg                                                22


<210>  83
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  83
gtgaagaccg ccgataccgc cgc                                               23


<210>  84
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  84
gggtgaaaaa caagggtggc acggca                                            26


<210>  85
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  85
tgccgtgcca cccttgtttt tcaccc                                            26


<210>  86
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  86
acgccaggcc cgttcacgac gaccgc                                            26


<210>  87
<211>  59
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  87
gctggtggac ccctggggcg agctggcgca ttcacctctc ccggaaaggt attgctcgc        59


<210>  88
<211>  65
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  88
aacagctttg cgaagacgag tcattcatac cattcatacc cttccggcga agtgcagttc       60

acccg                                                                   65


<210>  89
<211>  62
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  89
tcagtgctgc gaccaccgcg tacctgatcc gcattcacct ctcccggaaa ggtattgctc       60

gc                                                                      62


<210>  90
<211>  73
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  90
atcgcgatga tccggccgtt cccccagtcg atcgtccgca ttcataccct tccggcgaag       60

tgcagttcac ccg                                                          73


<210>  91
<211>  49
<212>  DNA
<213>  Streptomyces violaceusniger

<400>  91
tggccggaaa cctagggggt tgcgtggaaa gcaccggcgg gtgttcgct                   49


<210>  92
<211>  49
<212>  DNA
<213>  Streptomyces rapamycinicus

<400>  92
aggcaggacg tctagggggt tgcgtggact gcggcctgag gtgtcttct                   49


<210>  93
<211>  49
<212>  DNA
<213>  Streptomyces hygroscopicus

<400>  93
aggcaggaag cctagggggt tgcgtggact gcgacctggg gtgtcttct                   49


<210>  94
<211>  47
<212>  DNA
<213>  Micromonospora sp. S92-306401

<400>  94
aggtacgaca cctagggggt tgcgtcggct gcgaccccgg tgtctcc                     47


<210>  95
<211>  48
<212>  DNA
<213>  Actinoplanes sp. N01-109

<400>  95
agctcggccc cctagggggt tgcgcccgct gaggcggagg tgtttggc                    48


<210>  96
<211>  43
<212>  DNA
<213>  Streptomyces kanamyceticus

<400>  96
tgttgcccat ctagggggtt gcacgaataa cgtcacacgt act                         43


<210>  97
<211>  43
<212>  DNA
<213>  Streptomyces tacrolimicus

<400>  97
tgtcatatgt ctagggggtt gcacgaatac cgtcgcgcgt act                         43


<210>  98
<211>  43
<212>  DNA
<213>  Streptomyces ascomyceticus

<400>  98
ggacgctcat ctagggggtt gcacgcatac cgccgtgcgt aat                         43


<210>  99
<211>  39
<212>  DNA
<213>  Streptomyces violaceusniger

<400>  99
ggcgcctgtt ctagggggtt gcggggagtg gcgcgcaca                              39


<210>  100
<211>  66
<212>  PRT
<213>  Micromonospora sp. S92-306401

<400>  100

Gln Gly Ile Arg Ser Leu Thr Glu Ala Glu Arg Arg Val Ala Thr Leu 
1               5                   10                  15      


Ala Ala Ala Gly Gln Thr Asn Arg Glu Ile Ala Asp Gln Leu Phe Val 
            20                  25                  30          


Thr Ala Ser Thr Val Glu Gln His Leu Thr Asn Val Phe Arg Lys Leu 
        35                  40                  45              


Gly Val Lys Gly Arg Gln Gln Leu Pro Ala Glu Leu Ala Asp Leu Arg 
    50                  55                  60                  


Pro Pro 
65      


<210>  101
<211>  66
<212>  PRT
<213>  Streptomyces violaceusniger

<400>  101

Gln Arg Ser Thr Ser Leu Thr Asp Ala Glu Arg Arg Val Ala Ala Leu 
1               5                   10                  15      


Ala Ala Ala Gly Gln Thr Asn Arg Glu Ile Ala Lys Gln Leu Phe Val 
            20                  25                  30          


Thr Ala Ser Thr Val Glu Gln His Leu Thr Ser Val Phe Arg Lys Leu 
        35                  40                  45              


Gly Val Lys Gly Arg Lys Gln Leu Pro Thr Ala Leu Ala Asp Val Glu 
    50                  55                  60                  


Gln Thr 
65      


<210>  102
<211>  58
<212>  PRT
<213>  Streptomyces hygroscopicus

<400>  102

Gln Arg Ile Lys Ser Leu Thr Asp Ala Glu Arg Arg Val Ala Ser Leu 
1               5                   10                  15      


Ala Ala Gly Gly Gln Thr Asn Arg Val Ile Ala Asp Gln Leu Phe Val 
            20                  25                  30          


Thr Ala Ser Thr Val Glu Gln His Leu Thr Asp Val Ser Thr Gly Ser 
        35                  40                  45              


Arg Pro Pro Ala Pro Ala Ala Glu Leu Val 
    50                  55              


<210>  103
<211>  64
<212>  PRT
<213>  Streptomyces ascomyceticus

<400>  103

Gln Arg Ile Thr Ser Leu Thr Glu Ala Glu Arg Arg Val Ala Ser His 
1               5                   10                  15      


Ala Ala Val Gly Arg Thr Asn Lys Glu Ile Ala Ser Gln Leu Phe Val 
            20                  25                  30          


Thr Ser Ser Thr Val Glu Gln His Leu Thr Asn Val Phe Arg Lys Leu 
        35                  40                  45              


Gly Val Lys Gly Arg Gln Gln Leu Pro Lys Glu Leu Ser Asp Ala Gly 
    50                  55                  60                  


<210>  104
<211>  74
<212>  PRT
<213>  Streptomyces kanamyceticus

<400>  104

Gln Arg Ile Ala Ser Leu Thr Glu Ser Glu Arg Arg Val Ala Ala Leu 
1               5                   10                  15      


Ala Ala Val Gly Arg Thr Asn Arg Glu Ile Ala Glu Gln Leu Phe Val 
            20                  25                  30          


Thr Ala Ser Thr Val Glu Gln His Leu Thr Asn Val Phe Arg Lys Leu 
        35                  40                  45              


Ala Val Lys Gly Arg Gln Gln Leu Pro Lys Glu Leu Ala Asp Val Gly 
    50                  55                  60                  


Glu Pro Ala Asp Arg Asp Arg Arg Cys Gly 
65                  70                  


<210>  105
<211>  71
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  105

Ile Arg Thr Ser Pro Leu Thr Gln Arg Glu Trp Gln Val Leu Gly Leu 
1               5                   10                  15      


Ile Tyr Ser Gly Tyr Ser Asn Glu Gln Ile Ala Gly Glu Leu Glu Val 
            20                  25                  30          


Ala Ala Thr Thr Ile Lys Thr His Ile Arg Asn Leu Tyr Gln Lys Leu 
        35                  40                  45              


Gly Val Ala His Arg Gln Asp Ala Val Gln His Ala Gln Gln Leu Leu 
    50                  55                  60                  


Lys Met Met Gly Tyr Gly Val 
65                  70      


<210>  106
<211>  45
<212>  PRT
<213>  Streptomyces rapamycinicus

<400>  106

Leu Thr Asp Ala Glu Arg Arg Val Ala Ser Leu Ala Ala Gly Gly Gln 
1               5                   10                  15      


Thr Asn Arg Val Ile Ala Asp Gln Leu Phe Val Thr Ala Ser Thr Val 
            20                  25                  30          


Glu Gln His Leu Thr Asn Val Phe Arg Lys Leu Gly Val 
        35                  40                  45  


<210>  107
<211>  54
<212>  DNA
<213>  Streptomyces violaceusniger

<400>  107
cgcctggccg gaaacctagg gggttgcgtg gaaagcaccg gcgggtgttc gctt             54


<210>  108
<211>  48
<212>  DNA
<213>  Streptomyces filamentosus

<400>  108
cggcaggcag actaggggtt gcgtgggccg cacccgaggc attcgatt                    48


<210>  109
<211>  49
<212>  DNA
<213>  Streptomyces filamentosus

<400>  109
cggcaggcag actagggggt tgcgtgggcc gcacccgagg cattcgatt                   49


<210>  110
<211>  53
<212>  DNA
<213>  Streptomyces filamentosus

<400>  110
cggcaggcag aacacctagg gggttgcgtg ggccgcaccc gaggcattcg att              53


<210>  111
<211>  52
<212>  DNA
<213>  Streptomyces violaceusniger

<400>  111
ctgcaggcag aacacctggg ggttgcgcga accgggcgcg cggtatcgga tt               52


<210>  112
<211>  53
<212>  DNA
<213>  Streptomyces violaceusniger

<400>  112
ctgcaggcag aacacctagg gggttgcgcg aaccgggcgc gcggtatcgg att              53


