                         SEQUENCE LISTING

<110>  Genentech, Inc.
       F. Hoffmann-La Roche AG
 
<120>  DIAGNOSTIC AND THERAPEUTIC METHODS FOR CANCER

<130>  50474-133WO2

<150>  US 62/323,210
<151>  2016-04-15

<160>  20    

<170>  PatentIn version 3.5

<210>  1
<211>  5913
<212>  RNA
<213>  Homo sapiens

<400>  1
guggacgcag cgggcuuugg aaaggcccca aguuaaugag gcgugcgccg gcugccgagc       60

gccucuugga gcugggcuuu cccccgcggu gcgggcgcca ggagccgccu uuuccgcugg      120

gugucacucg ggggugggga agauggccca uucaaaagcg ccgcgagggg gcccggccag      180

ugcccuucag ugagcgcucg caagaggacg gcagaggccc ggcagcucgg agcuccggga      240

ccuuguggcg caucaggacg cggcuguccc ucugccggga cccagagccg ccgccgccgc      300

ucugccuccu gcguguuagc cuccucugcg cgcuccgggc aggcggccgu gggagccgcu      360

ggggcgagga cggcgcgagg cugcugcugc ugcccccggc ccgcgcggcu ggaaacggag      420

aggccgagcc aagcggcggc cccucuuaug cugggaggau gcuggagagu agcggcugca      480

aagcgcugaa ggagggcgug cuggagaagc gcagcgacgg guuguugcag cucuggaaga      540

aaaaguguug cauccucacc gaggaagggc ugcugcuuau cccgcccaag cagcugcaac      600

accagcagca gcagcagcaa cagcagcagc agcagcagca acaacagccc gggcaggggc      660

cggccgagcc gucccaaccc aguggccccg cugucgccag ccucgagccg ccggucaagc      720

ucaaggaacu gcacuucucc aacaugaaga ccguggacug uguggagcgc aagggcaagu      780

acauguacuu cacuguggug auggcagagg gcaaggagau cgacuuucgg ugcccgcaag      840

accagggcug gaacgccgag aucacgcugc agauggugca guacaagaau cgucaggcca      900

uccuggcggu caaauccacg cggcagaagc agcagcaccu gguccagcag cagccccccu      960

cgcagccgca gccgcagccg cagcuccagc cccaacccca gccucagccu cagccgcaac     1020

cccagcccca aucacaaccc cagccucagc cccaacccaa gccucagccc cagcagcucc     1080

acccguaucc gcauccacau ccacauccac acucucaucc ucacucgcac ccacacccuc     1140

acccgcaccc gcauccgcac caaauaccgc acccacaccc acagccgcac ucgcagccgc     1200

acgggcaccg gcuucuccgc agcaccucca acucugccug aaaggggcag cucccgggca     1260

agacaagguu uugaggacuu gaggaagugg gacgagcaca uuucuauugu cuucacuugg     1320

aucaaaagca aaacagucuc uccgccccgc accagaucaa guaguuugga caucacccua     1380

cugaaaacuu gcgauucuuc uuaguuuucu gcauacuuuu caucacgaug caggaaacga     1440

uuucgaguca agaagacuuu uauuuaugaa ccuuugaaag gaucgucuug uauggugaau     1500

uuucuaggag cgaugaugua cuguaauuuu auuuuaaugu auuuugauuu augauuauuu     1560

auuaguuuuu uuuuaaaugc uuguucuaag acauuucuga auguagacca uuuuccaaaa     1620

aggaaacuuu auuuucaaaa accuaauccg uaguaauucc uaaucuugga gaauaaaaaa     1680

gggcggugga ggggaaaaca uuaagaauuu auucauuauu ucucgaguac uuucagaaag     1740

ucugacacuu ucauuguugu gccagcuggu ugaaauuaaa acucugauau uacuuuuuuu     1800

gaggauuuuu auuuuuguuu uugcuuaaac auauaguuug ucuagaaguu uaaaaagcua     1860

aaaguuaaaa augguguaau uaugaaaauc uaacacucaa gauaguuucu aaaaggaaau     1920

caguaguuaa ggauaccuga uuucaaaaua uuuaaagcau aaccuaacug augguaggau     1980

gauuguaucu ugaauaugug guagggccac aucuauugua ggaaaaccuu gcuuuuauca     2040

ucugugugua aagggcuuaa uaaggagaag aggccuuuug acugauuugu gaguauaaau     2100

gcauuugcug uuucauuuca aaaauguugu ggaggaaaag aguacauuua acuuguauaa     2160

gagaauauuu guacuccugu ccaggcugca ggaccuuucu ucgagagcuu ugcacacuug     2220

acuugaacca cauuuucuga ucccuuuacu uuguuuuaga agcacacuga aaaaucucgu     2280

uguuuaaagu acaauuugua aauauuucaa aggucuagga gucauaacuu uuguuuucau     2340

acugaaaaug auguugauca gagaaaccaa cuguuuugcu uuucauugcu cugugagaaa     2400

uuugaggauu cuguuuugcu guuagguaag cuaaacucag aaauugaaaa ggaaaagacu     2460

ggauaaacac aggauuuuca guaagaaaac aaccccaguc uugucuuaga agccacuugu     2520

ugaggagucu guugggggaa aaaagaggau augcuuuuaa agguagaaca aaccuucuuc     2580

uguguuaaau caaaaggaug uucaaaaucc accaggacag augcuacuug gguuuaaaug     2640

gagccauaga ugauacaaag uccucuuggg gcugaaaauc acuuccuauu ugcauggcuu     2700

uacuaacugg uuucuguuuu ccauuaucuu uuucacagaa agucuugguc aguauuuuuc     2760

cagcauuuaa auugaaacgg ucaguauuag accacugcua gguuauguag ucaagaaaua     2820

aaaauagaau uacaugcuac agaugucuuu auucuccuuc caucuagaaa ggaguuccaa     2880

ggucaaauua cuuuuuagug caauaguuaa augacauuuu gagaucauaa cucauaucca     2940

aaaaguugca gggaaaauua aaauagcuuu ccccuauuaa gcuaauggca aacaaaacuu     3000

aaguggaccc ccacuuccag ugguuguuua gguugcaguu gugaaaauau gcugccaaca     3060

uuuaaaaacu uguuucauau guauauaugu auacacauau augaauaugu auguauauau     3120

acauauauga gaacaugugu guacacauau augaauaugu auauaugugu auguauguau     3180

auauguauau gaaaugagag ccacaucuaa agauuucuua aaucaaguuu gguucagcuu     3240

ccuuagaacu guggcuguac uuuuugagga guaccucaua guacuauauu uuuaaugcau     3300

gcaaaucaua auagcuccaa augaaccaca guuuuuuccc aauggaggau uuuuuuuuaa     3360

uucuuguacu aaaaaaaaaa aauccauacc aaauauuuuu acaaauuaag auugauguag     3420

guuuuaaaaa aggcauuugu auguuguuag cuuacauaug gggcuaggua auuucauugc     3480

uuaaaaagau gcgccuaggc ucccucuugg uggcuggauu ucuuuuucuu cgcccguggu     3540

ggccaugguu cuuaauaggg ccaccggaau caugguuucu uuuuuuuuuu uuuuuuuuga     3600

gauggagucu cgcccuguga cccaggcugg agugcagugg cacgaucucg gcucacugca     3660

accucugccu ccuggguuca cgccauucuc cugucucagc cuccugagua gcugggacua     3720

caggugaaug ccaccacgcc cggcugauuu uuguauuuuu aguagagaug ggguuucacc     3780

auagugguca ggcuguucuc gaacuccuga ccucagguga uccaccugcc uuggccuccc     3840

aaagugcuag gauuacaggu gugagccacc acacccggcc ccagaauaau gguuucuuga     3900

cuuucuguag cccuuguucc uuagucugcu gugauauuua uguugaccuu uaucauuuuc     3960

uauucugaac cccucuuagc auuuaaugug aaaucuaaga aauuagaagu agaauggcuu     4020

uuauuguuuu gacaccuuug aaauuauuau uaauaauuuu uccagagcaa aaaagcaaac     4080

acgcucaaua agacuaaaca aaacaaaaua uaaauguaca ucauuuaaug ucccaguggc     4140

ucuauucuac cuguaagaaa augauacaaa accaccuaag auauuuugaa gccugacaaa     4200

ucagcuucau ggaaaaaggu aaaaaaugca uuuuucaacc gaaagggcag auccaauaga     4260

agacccgcuc cuuaaauaaa cauaaaaugu aaaaaguugg aaaauuaaga guaauguucc     4320

aucuggaaac ugaacuuuug uccuugaacu uguguuggca ccaagccuca uacacaguga     4380

gcucaauaac uguugggaca aaggaaggaa ggacaaaaug uguaacuucc cagcaucugg     4440

gagaugcugu cucuugccuc acugaguguu ccuuuucuuu gcucucaugu cauucccuga     4500

gaacaaugaa uucugggaca ggcuaaacau caugaugaag uuucuuaaac agacuuucuu     4560

aguggaaauc cauuuagauc ugggugugcu cuauggggag ugcugacguc aaagagcaaa     4620

ugucuauaag gggcccuuuu aaaaugaaca uuuuccucau ugagcaagcu gggauucucu     4680

aauguagaaa ucaagccauc uuuauaauuu cacuucagau guuuauguuu uuguuuuuuu     4740

ugucuccaau gaugguaaaa auaaaaacua cgcauuacuu aaaggaguuu cccucacaug     4800

uaaacacugu uaggaagucu ggauuaaguu gaaaguccug uuuuaacuuu uuuucucuca     4860

uauaccaaac acucuguauu ucucuuaaag aagcccuuua agagaaagcc cuaauuuuau     4920

aucugacagu aaaguuugcu gcaaguguau gaguucaaac acaucccuug uuuucugucc     4980

cuaggggaaa agucauguag uuuuagcuug gcuccagugu uaauauuaua uucaguagca     5040

gccuuagaag aguggucuaa gacuugaacc uggagcaauu uuauagcaca gaauccuacg     5100

aagauaggac ugugaacauu uguuuucuuu uucgugugug ucaaacuaac ugguuuuugc     5160

uuuaccaaua aaauguccuc ggcagaguaa auuuuaaacg ugaaaauuau agaucuugau     5220

auugaaucca ucagugauuc aagagauaca ccuauuugcc uaaaacaacc uaagauguau     5280

ugguuaugga aucauguguu ggauagguuc uuaagaccug uuuccucaaa ucuugacaca     5340

guuuucaagg guggcuuauu gacuugcacg guugggcaga uaauccagau uuaccuaaga     5400

uuggguaaaa aagucaucug ugacuuugcu ggcagggcau uugcuaagug gaguacagga     5460

ucuaaaaggg uuuucuuaga aagggcaaua uuguccaaug aaguaagcag aaggacucug     5520

gguuagaagc aucugcacaa aaacugguga gaccuacucu ccacugcucu gcagcuggau     5580

ggcugauggc aggcugagca guggggaagc agguuuuaac aacagggagu ccuuccaggu     5640

cacuguauau ugagaagaaa cauaaaacua uugucuguua cauuccgagg ucagccuucu     5700

ucuuaacguu uuauaauaug caaaugccag cuucuggaaa gcaaguauca ucauguacca     5760

aaugcuuuau acaccaucac auucaugaau uuuuuagcau ggucagaacu uguguaaaua     5820

ugucucuuag augauuuugg ggagauguga uuuauuuuuc auauuuucaa aaugcauuuc     5880

auuucaaaua aaguuaucua uugagacaac cga                                  5913


<210>  2
<211>  401
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Arg Arg Ala Pro Ala Ala Glu Arg Leu Leu Glu Leu Gly Phe Pro 
1               5                   10                  15      


Pro Arg Cys Gly Arg Gln Glu Pro Pro Phe Pro Leu Gly Val Thr Arg 
            20                  25                  30          


Gly Trp Gly Arg Trp Pro Ile Gln Lys Arg Arg Glu Gly Ala Arg Pro 
        35                  40                  45              


Val Pro Phe Ser Glu Arg Ser Gln Glu Asp Gly Arg Gly Pro Ala Ala 
    50                  55                  60                  


Arg Ser Ser Gly Thr Leu Trp Arg Ile Arg Thr Arg Leu Ser Leu Cys 
65                  70                  75                  80  


Arg Asp Pro Glu Pro Pro Pro Pro Leu Cys Leu Leu Arg Val Ser Leu 
                85                  90                  95      


Leu Cys Ala Leu Arg Ala Gly Gly Arg Gly Ser Arg Trp Gly Glu Asp 
            100                 105                 110         


Gly Ala Arg Leu Leu Leu Leu Pro Pro Ala Arg Ala Ala Gly Asn Gly 
        115                 120                 125             


Glu Ala Glu Pro Ser Gly Gly Pro Ser Tyr Ala Gly Arg Met Leu Glu 
    130                 135                 140                 


Ser Ser Gly Cys Lys Ala Leu Lys Glu Gly Val Leu Glu Lys Arg Ser 
145                 150                 155                 160 


Asp Gly Leu Leu Gln Leu Trp Lys Lys Lys Cys Cys Ile Leu Thr Glu 
                165                 170                 175     


Glu Gly Leu Leu Leu Ile Pro Pro Lys Gln Leu Gln His Gln Gln Gln 
            180                 185                 190         


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Pro Gly Gln Gly 
        195                 200                 205             


Pro Ala Glu Pro Ser Gln Pro Ser Gly Pro Ala Val Ala Ser Leu Glu 
    210                 215                 220                 


Pro Pro Val Lys Leu Lys Glu Leu His Phe Ser Asn Met Lys Thr Val 
225                 230                 235                 240 


Asp Cys Val Glu Arg Lys Gly Lys Tyr Met Tyr Phe Thr Val Val Met 
                245                 250                 255     


Ala Glu Gly Lys Glu Ile Asp Phe Arg Cys Pro Gln Asp Gln Gly Trp 
            260                 265                 270         


Asn Ala Glu Ile Thr Leu Gln Met Val Gln Tyr Lys Asn Arg Gln Ala 
        275                 280                 285             


Ile Leu Ala Val Lys Ser Thr Arg Gln Lys Gln Gln His Leu Val Gln 
    290                 295                 300                 


Gln Gln Pro Pro Ser Gln Pro Gln Pro Gln Pro Gln Leu Gln Pro Gln 
305                 310                 315                 320 


Pro Gln Pro Gln Pro Gln Pro Gln Pro Gln Pro Gln Ser Gln Pro Gln 
                325                 330                 335     


Pro Gln Pro Gln Pro Lys Pro Gln Pro Gln Gln Leu His Pro Tyr Pro 
            340                 345                 350         


His Pro His Pro His Pro His Ser His Pro His Ser His Pro His Pro 
        355                 360                 365             


His Pro His Pro His Pro His Gln Ile Pro His Pro His Pro Gln Pro 
    370                 375                 380                 


His Ser Gln Pro His Gly His Arg Leu Leu Arg Ser Thr Ser Asn Ser 
385                 390                 395                 400 


Ala 
    


<210>  3
<211>  2032
<212>  RNA
<213>  Homo sapiens

<400>  3
agggugagaa aaaggcaggg ugccgggugg agggagugcc cgccucugcu ccguguggac       60

agucuagccc ggagcgggug ggagcgucgc ccugccuggc gccgggucuc ugcgguucgg      120

aagugcagcu cucucucuuc cguucuucgu ggucagccug ggucacacuu auuuuauuuu      180

uggaagcucg ggcugaccca gcgcaggaag aaagucauca agcggucgcg aucauuuucc      240

auuaccugaa agaguucaga uguguucuaa gccugcugga gugaccacac uuccaagacc      300

ugauggaggc cagagcucag aguggcaacg ggucgcagcc cuugcugcag acgccccgug      360

acgguggcag acagcguggg gagcccgacc ccagagacgc ccucacccag cagguacaug      420

ucuugucucu ggaucagauc agagccaucc gaaacaccaa ugaguacaca gaggggccua      480

cugucguccc aagaccuggg cucaagccug cuccucgccc cuccacucag cacaaacacg      540

agagacucca cggucugccu gagcaccgcc agccuccuag gcuccagcac ucgcaggucc      600

auucuucugc acgagccccu cuguccagau ccauaagcac ggucagcuca gggucgcgga      660

gcaguacgag gacaaguacc agcagcagcu ccucugaaca gagacugcua ggaucauccu      720

ucuccuccgg gccuguugcu gauggcauaa uccgggugca acccaaaucu gagcucaagc      780

caggugagcu uaagccacug agcaaggaag auuugggccu gcacgccuac aggugugagg      840

acuguggcaa gugcaaaugu aaggagugca ccuacccaag gccucugcca ucagacugga      900

ucugcgacaa gcagugccuu ugcucggccc agaacgugau ugacuauggg acuuguguau      960

gcugugugaa aggucucuuc uaucacuguu cuaaugauga ugaggacaac ugugcugaca     1020

acccauguuc uugcagccag ucucacuguu guacacgaug gucagccaug ggugucaugu     1080

cccucuuuuu gccuuguuua ugguguuacc uuccagccaa ggguugccuu aaauugugcc     1140

agggguguua ugaccggguu aacaggccug guugccgcug uaaaaacuca aacacaguuu     1200

gcugcaaagu ucccacuguc cccccuagga acuuugaaaa accaacauag caucauuaau     1260

caggaauauu acaguaauga ggauuuuuuc uuucuuuuuu uaauacacau augcaaccaa     1320

cuaaacaguu auaaucuugg cacuguuaau agaaaggugg gauagucuuu gcuguuugcg     1380

gugaaaugcu uuuuguccau gugccguuuu aacugauaug cuuguuagaa cucagcuaau     1440

ggagcucaaa guaugagaua cagaacuugg ugacccaugu auugcauaag cuaaagcaac     1500

acagacacuc cuaggcaaag uuuuuguuug ugaauaguac uugcaaaacu uguaaauuag     1560

cagaugacuu uuuuccauug uuuucuccag agagaaugug cuauauuuuu guauauacaa     1620

uaauauuugc aacugugaaa aacaaguugu gccauacuac auggcacaga cacaaaauau     1680

uauacuaaua uguuguacau ucggaagaau gugaaucaau caguauguuu uuagauugua     1740

uuuugccuua cagaaagccu uuauuguaag acucugauuu cccuuuggac uucauguaua     1800

uuguacaguu acaguaaaau ucaaccuuua uuuucuaauu uuuucaacau auuguuuagu     1860

guaaagaaua uuuauuugaa guuuuauuau uuuauaaaaa agaauauuua uuuuaagagg     1920

caucuuacaa auuuugcccc uuuuaugagg augugauagu ugcugcaaau gagggguuac     1980

agaugcauau guccaauaua aaauagaaaa uauauuaacg uuugaaauua aa             2032


<210>  4
<211>  315
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Glu Ala Arg Ala Gln Ser Gly Asn Gly Ser Gln Pro Leu Leu Gln 
1               5                   10                  15      


Thr Pro Arg Asp Gly Gly Arg Gln Arg Gly Glu Pro Asp Pro Arg Asp 
            20                  25                  30          


Ala Leu Thr Gln Gln Val His Val Leu Ser Leu Asp Gln Ile Arg Ala 
        35                  40                  45              


Ile Arg Asn Thr Asn Glu Tyr Thr Glu Gly Pro Thr Val Val Pro Arg 
    50                  55                  60                  


Pro Gly Leu Lys Pro Ala Pro Arg Pro Ser Thr Gln His Lys His Glu 
65                  70                  75                  80  


Arg Leu His Gly Leu Pro Glu His Arg Gln Pro Pro Arg Leu Gln His 
                85                  90                  95      


Ser Gln Val His Ser Ser Ala Arg Ala Pro Leu Ser Arg Ser Ile Ser 
            100                 105                 110         


Thr Val Ser Ser Gly Ser Arg Ser Ser Thr Arg Thr Ser Thr Ser Ser 
        115                 120                 125             


Ser Ser Ser Glu Gln Arg Leu Leu Gly Ser Ser Phe Ser Ser Gly Pro 
    130                 135                 140                 


Val Ala Asp Gly Ile Ile Arg Val Gln Pro Lys Ser Glu Leu Lys Pro 
145                 150                 155                 160 


Gly Glu Leu Lys Pro Leu Ser Lys Glu Asp Leu Gly Leu His Ala Tyr 
                165                 170                 175     


Arg Cys Glu Asp Cys Gly Lys Cys Lys Cys Lys Glu Cys Thr Tyr Pro 
            180                 185                 190         


Arg Pro Leu Pro Ser Asp Trp Ile Cys Asp Lys Gln Cys Leu Cys Ser 
        195                 200                 205             


Ala Gln Asn Val Ile Asp Tyr Gly Thr Cys Val Cys Cys Val Lys Gly 
    210                 215                 220                 


Leu Phe Tyr His Cys Ser Asn Asp Asp Glu Asp Asn Cys Ala Asp Asn 
225                 230                 235                 240 


Pro Cys Ser Cys Ser Gln Ser His Cys Cys Thr Arg Trp Ser Ala Met 
                245                 250                 255     


Gly Val Met Ser Leu Phe Leu Pro Cys Leu Trp Cys Tyr Leu Pro Ala 
            260                 265                 270         


Lys Gly Cys Leu Lys Leu Cys Gln Gly Cys Tyr Asp Arg Val Asn Arg 
        275                 280                 285             


Pro Gly Cys Arg Cys Lys Asn Ser Asn Thr Val Cys Cys Lys Val Pro 
    290                 295                 300                 


Thr Val Pro Pro Arg Asn Phe Glu Lys Pro Thr 
305                 310                 315 


<210>  5
<211>  4941
<212>  RNA
<213>  Homo sapiens

<400>  5
auucauaaaa aagccauuuu cccaggcagu gguugcaaca ucgccgcgga gguagcgagc       60

ugagcugaca gcgcggagcu ggcgcugugg agcgcaggga gccuugccgg uuccuccgac      120

cggcgucugc gaguacagcg gcggcuaacc ugccccggcu ucaggauuua cacagacgug      180

gggcgaugcu ugugacccug cagcuccuca aaggccccua gaagccuguu ucuccguaca      240

guccaggacc uccagcccca uggagccccc gaucccacag agcgcccccu ugacucccaa      300

cucagucaug guccagcccc uucuugacag ccggaugucc cacagccggc uccagcaccc      360

acucaccauc cuacccauug accaggugaa gaccagccau guggagaaug acuacauaga      420

caacccuagc cuggcccuga ccaccggccc aaagcggacc cggggcgggg ccccagagcu      480

ggccccgacg cccgcccgcu gugaccagga ugucacccac cauuggaucu ccuucagcgg      540

gcgccccagc ucugugagca gcagcagcag cacauccucu gaccaacggc ucuuagacca      600

cauggcacca ccacccgugg cugaccaggc cucaccaagg gcugugcgca uccagcccaa      660

ggugguccac ugccagccgc uggaccucaa gggcccggcg gucccacccg agcuggacaa      720

gcacuucuug cugugcgagg ccugugggaa guguaaaugc aaggagugug cauccccccg      780

gacguugccu uccugcuggg ucugcaacca ggagugccug ugcucagccc agacucuggu      840

caacuauggc acgugcaugu guuuggugca gggcaucuuc uaccacugca cgaaugagga      900

cgaugagggc uccugcgcug accaccccug cuccugcucc cgcuccaacu gcugcgcccg      960

cugguccuuc augggugcuc ucuccguggu gcugcccugc cugcucugcu accugccugc     1020

caccggcugc gugaagcugg cccagcgugg cuacgaccgu cugcgccgcc cugguugccg     1080

cugcaagcac acgaacagcg ucaucugcaa agcagccagc ggggaugcca agaccagcag     1140

gcccgacaag ccuuucugac aguuuguguc gaagccccag ugcucugccu ggaaaccugg     1200

uucucuucug acaucuaaga agacugcagc aaggucagag guuuuagccu ccugaggcug     1260

accuugcuag ucugcccacu cccuaccccc agcuucggaa aauacagaga ccaccaccac     1320

guacccugua uuccccaagg ugaugaagaa gcacuuuggg gcuuuuuuuc aggguccuga     1380

aacuuugugu caaacagaca augcaggggc aggguguggu uuggggggaa auuuuucuuu     1440

uucagaagac agaacacaga uguggacaca uauccggaaa cugcagcugc uugaaugccu     1500

ucccagcccc uccuucuccc ucccucccuc cgcccccccc cccuuccucu uuuccauugu     1560

cuuuggcucu cacaggagcu agcugccugg gaggaauugu uaacugagua ccaggguacc     1620

uuuaaagaag acccuuggag ucuucuauac cuucuucucc uuccccaucu cacuccaccc     1680

cacuuugucc cugaugucuu ggggaaggug uagaacaccc uagcaguucc uauuguauau     1740

acuugggagc cacugagaac agaggacggc cagugagucc aagccucguu ccuccuucug     1800

ccuccccgga gccacaggau ggauuuagga gccacugcuc agugcacuuc ucccuuccaa     1860

cugcaucaac uaacucucgg ggguguucug cucaccacac cguccuucgg uucuuacuga     1920

gucacagacu cgccugccca cuacgugucc uggguucucu cuacucagau cccuuccaga     1980

aacuuuauau ggguagagga agccagggcg gcaaaugcga gaccaaauau cauuuugcca     2040

augagucuga ggcugugguc ucuggaucca gucauuaugu uuuuauagaa uaauuaaacc     2100

ggaugcuaac gguguuuuaa aaaauaauaa uaaaacaacu uguuuccuuu uggccacccc     2160

caggaagggc ugauuucaaa aucugggggc gagcaaccuc aaggaacaca auuucccucc     2220

cuaucaacaa gaggauuuua acagcaaaga agagaggcag caccucccau uggcagaaug     2280

accgcugagc caggcugggu uuggguuucu ucucuucuga uucugcugcu cacugucaua     2340

gccuuuugug uauagugaug ugucuguauc uuuaauguaa auagagagau gaugaaaaaa     2400

gagucuauuu uaguguuagg aagccccagc aggggagucg gaagagcuug gaagagcugg     2460

ggagagggua ggggaaaggu uuuuccaggg gccacugggu uugagcccug cuucugugca     2520

cagccacacc acccucuccc gacagcccuc aaagacguag caacucuuuc ucucaaggug     2580

cuaaaggacu cagaaggugc agcacgucca guggguaggu acuuguugca ugcaaaagcu     2640

guaguguauc ugguccuucc uccccagcuu uugugugggg uucuugcuuu gugugguauu     2700

uuguuuuccc cucuaaugag agggcauggc cugagucaga agagcuaccc caggugaaac     2760

uggaagugca ugaggcagag cguccguagc auuuccaguu uguucuguau aggaacagag     2820

gugccuccgg gaaggaggca gcgagguagg uagcuaugau aggcaccuaa ugcuucucaa     2880

ggacuuauuu uuuccuucuu gaagacuagu aguaacaucu uaugauuuag aguaaguuga     2940

uuguaaccau agguauuuau ugauuggagg aagggagggu cauauuauuu ucggcuuuau     3000

uuauguaaca uuugcuagcu uguaaaaggc gaaugugaaa uauugcaucu gcauuuucca     3060

aggcugauuc guguagcuac ccuugccaca guugugacgg auguauggau guucuugaac     3120

auuucagaag gagugguaga aaaaaacaca cauucagcca accacuuaua ugaauugaau     3180

guaucagaag uguacugaag ggacuggaga ugguuuuccu cagaugaggg ggccccaaaa     3240

uugauagugc acaucugcac gcuuucugcg aggccucaga acuucccagg gccccucccu     3300

caaauugucu ccaugggaaa cuugacccag uggcaaguug cacuuuggug aucuuggugg     3360

ucuacacacc cguucugugg agagucgauu uacauaagcu guguauacac acacacacac     3420

acacacacac accccuaccc cacacugacu gucuaccgac aaagacccua uuuccuggca     3480

aacggccucc ugaacccuga cuuuuugugu acauacuugu aaacacggau uuuucugggu     3540

uuugguuugc uuuuuccuuu uuucccccug ccccuguucu agcuuguucu ucuugguuug     3600

cuuucaaccu gcuugaugga ugucugcaga gugcucucua agaguccacc ucagugccuc     3660

gugugcucag uggucauggg aaaggagcga aggaaccauc cuugguucuc ccagcuuggu     3720

uguguagcaa ucccucagca uuguuuuucu cagcuucuug gcaaaaauua aaacaacaac     3780

aacaacaaca acaacaacaa caaacagaag gauaaacugg cuugccugug gacccucccc     3840

ggcucugggg ccagucgaga gccacugagg gacccagcac ucagagacac aacacacaug     3900

uguagcugcu ucuggcugag uguguuuccu gucaccaaug gccuguuugg cuggacgaug     3960

ccucggcuug accuuuuuug aaaagugcug guuaguuccc gccccuggua aaccuggggu     4020

aggugggggu ucugucuuaa cucgaggggc accugggauc caggacgcuu cuagggggcu     4080

cuggcugccc guguuaauga aggacagcgc uuccgcgagc acccugggaa cugggucuug     4140

gguagcaaag cccucccaga gaaaagauug ggcacaacua aggcuuuccu gagcaggaag     4200

ggggugaaga ccaaucccuu ccuuuggucc uuugguacgc acccccucag agcugagaug     4260

gaagacaugg cuaguucuuu ucagccuugu ggagccuguc agucgccauc auaccucgag     4320

ugaggcccag cuagauaaug acuuguccaa gauggcacac guggaaaguu gaucugcacc     4380

agaacccgga ugacugucac cuugaagcau ccuguucucc uucugugcug ucccaggaag     4440

ugucuggcgg gcgugggcag cacagcucua cacuguacga uucacuaggg cauccugcga     4500

gccucacuag ccuucugguu caugccuuug acaagcauuu uugugccccc ucugcuuacu     4560

gugacagucg augaugaauc uugcguugcc auuuucugcu guggguaacu gcgugcagug     4620

ucuugccuug cuuucucuuc uuacuguccc acagcuuggu uucauguuac aaacagaaaa     4680

gcucgaggcu cccaccccgc cacaucccaa cuucauuucc cccucacugu agcccauuuc     4740

caccccacca caaaguugcc acagguuuuc uuuguauaga auauuuauuu ugaagcucua     4800

uuuuaauagu auuuauuuua gaaagucuac uauuguaaga guucuucugu uugugaagaa     4860

aaaaacaagu uaaaaacuga auguacugau uuagaaaaua uauauaaaua uauauuguua     4920

aauauacacg ggacugccgu u                                               4941


<210>  6
<211>  299
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Glu Pro Pro Ile Pro Gln Ser Ala Pro Leu Thr Pro Asn Ser Val 
1               5                   10                  15      


Met Val Gln Pro Leu Leu Asp Ser Arg Met Ser His Ser Arg Leu Gln 
            20                  25                  30          


His Pro Leu Thr Ile Leu Pro Ile Asp Gln Val Lys Thr Ser His Val 
        35                  40                  45              


Glu Asn Asp Tyr Ile Asp Asn Pro Ser Leu Ala Leu Thr Thr Gly Pro 
    50                  55                  60                  


Lys Arg Thr Arg Gly Gly Ala Pro Glu Leu Ala Pro Thr Pro Ala Arg 
65                  70                  75                  80  


Cys Asp Gln Asp Val Thr His His Trp Ile Ser Phe Ser Gly Arg Pro 
                85                  90                  95      


Ser Ser Val Ser Ser Ser Ser Ser Thr Ser Ser Asp Gln Arg Leu Leu 
            100                 105                 110         


Asp His Met Ala Pro Pro Pro Val Ala Asp Gln Ala Ser Pro Arg Ala 
        115                 120                 125             


Val Arg Ile Gln Pro Lys Val Val His Cys Gln Pro Leu Asp Leu Lys 
    130                 135                 140                 


Gly Pro Ala Val Pro Pro Glu Leu Asp Lys His Phe Leu Leu Cys Glu 
145                 150                 155                 160 


Ala Cys Gly Lys Cys Lys Cys Lys Glu Cys Ala Ser Pro Arg Thr Leu 
                165                 170                 175     


Pro Ser Cys Trp Val Cys Asn Gln Glu Cys Leu Cys Ser Ala Gln Thr 
            180                 185                 190         


Leu Val Asn Tyr Gly Thr Cys Met Cys Leu Val Gln Gly Ile Phe Tyr 
        195                 200                 205             


His Cys Thr Asn Glu Asp Asp Glu Gly Ser Cys Ala Asp His Pro Cys 
    210                 215                 220                 


Ser Cys Ser Arg Ser Asn Cys Cys Ala Arg Trp Ser Phe Met Gly Ala 
225                 230                 235                 240 


Leu Ser Val Val Leu Pro Cys Leu Leu Cys Tyr Leu Pro Ala Thr Gly 
                245                 250                 255     


Cys Val Lys Leu Ala Gln Arg Gly Tyr Asp Arg Leu Arg Arg Pro Gly 
            260                 265                 270         


Cys Arg Cys Lys His Thr Asn Ser Val Ile Cys Lys Ala Ala Ser Gly 
        275                 280                 285             


Asp Ala Lys Thr Ser Arg Pro Asp Lys Pro Phe 
    290                 295                 


<210>  7
<211>  5625
<212>  RNA
<213>  Homo sapiens

<400>  7
accuagcgcc cccucccccg ggagcgcgga ggagcauuaa uaaaccucua agccgaggag       60

aaaacucugg cuggggcagu gcgcugagcg ccggaggagc guaggcaggg cagcgcuggc      120

gccaguggcg acaggagccg cgcgaccggc aaaaauacac gggaggccgu cgccgaaaag      180

aguccgcggu ccucucucgu aaacacacuc uccuccaccg gcgccucccc cuccgcucug      240

cgcgccgccc ggcugggcgc ccgaggccgc uccgacugcu augugaccgc gaggcugcgg      300

gaggaagggg acagggaaga agaggcucuc ccgcgggagc ccuugaggac caaguuugcg      360

gccacuucug caggcguccc uucuuagcuc ucgcccgccc cuuucugcag ccuaggcggc      420

ccggguucuc uucucuuccu cgcgcgccca gccgccucgg uucccggcga ccauggugac      480

gauggaggag cugcgggaga uggacugcag ugugcucaaa aggcugauga accgggacga      540

gaauggcggc ggcgcgggcg gcagcggcag ccacggcacc cuggggcugc cgagcggcgg      600

caagugccug cugcuggacu gcagaccguu ccuggcgcac agcgcgggcu acauccuagg      660

uucggucaac gugcgcugua acaccaucgu gcggcggcgg gcuaagggcu ccgugagccu      720

ggagcagauc cugcccgccg aggaggaggu acgcgcccgc uugcgcuccg gccucuacuc      780

ggcggucauc gucuacgacg agcgcagccc gcgcgccgag agccuccgcg aggacagcac      840

cgugucgcug guggugcagg cgcugcgccg caacgccgag cgcaccgaca ucugccugcu      900

caaaggcggc uaugagaggu uuuccuccga guacccagaa uucuguucua aaaccaaggc      960

ccuggcagcc aucccacccc cgguuccccc cagugccaca gagcccuugg accugggcug     1020

cagcuccugu gggaccccac uacacgacca gggggguccu guggagaucc uucccuuccu     1080

cuaccucggc agugccuacc augcugcccg gagagacaug cuggacgccc ugggcaucac     1140

ggcucuguug aaugucuccu cggacugccc aaaccacuuu gaaggacacu aucaguacaa     1200

gugcauccca guggaagaua accacaaggc cgacaucagc uccugguuca uggaagccau     1260

agaguacauc gaugccguga aggacugccg ugggcgcgug cuggugcacu gccaggcggg     1320

caucucgcgg ucggccacca ucugccuggc cuaccugaug augaagaaac gggugaggcu     1380

ggaggaggcc uucgaguucg uuaagcagcg ccgcagcauc aucucgccca acuucagcuu     1440

cauggggcag cugcugcagu ucgaguccca ggugcuggcc acguccugug cugcggaggc     1500

ugcuagcccc ucgggacccc ugcgggagcg gggcaagacc cccgccaccc ccaccucgca     1560

guucgucuuc agcuuuccgg ucuccguggg cgugcacucg gcccccagca gccugcccua     1620

ccugcacagc cccaucacca ccucucccag cuguuagagc cgcccugggg gccccagaac     1680

cagagcuggc ucccagcaag gguaggacgg gccgcaugcg ggcagaaagu ugggacugag     1740

cagcugggag caggcgaccg agcuccuucc ccaucauuuc uccuuggcca acgacgaggc     1800

cagccagaau ggcaauaagg acuccgaaua cauaauaaaa gcaaacagaa cacuccaacu     1860

uagagcaaua acggcugccg cagcagccag ggaagaccuu gguuugguuu augugucagu     1920

uucacuuuuc cgauagaaau uucuuaccuc auuuuuuuaa gcaguaaggc uugaagugau     1980

gaaacccaca gauccuagca aaugugccca accagcuuua cuaaaggggg aggaagggag     2040

ggcaaaggga ugagaagaca aguuucccag aagugccugg uucuguguac uugucccuuu     2100

guugucguug uuguaguuaa aggaauuuca uuuuuuaaaa gaaaucuucg aagguguggu     2160

uuucauuucu cagucaccaa cagaugaaua auuaugcuua auaauaaagu auuuauuaag     2220

acuuucuuca gaguaugaaa guacaaaaag ucuaguuaca guggauuuag aauauauuua     2280

uguugauguc aaacagcuga gcaccguagc augcagaugu caaggcaguu aggaaguaaa     2340

uggugucuug uagauaugug caagguagca ugaugagcaa cuugaguuug uugccacuga     2400

gaagcaggcg gguugggugg gaggaggaag aaagggaaga auuagguuug aauugcuuuu     2460

uaaaaaaaaa agaaaagaaa aagacagcau cucacuaugu ugccaaggcu caucuugaga     2520

agcaggcggg uuggguggga ggaggaagaa agggaagaau uagguuugaa uugcuuuuuu     2580

aaaaaaaaag aaaagaaaaa aaaagacagc aucucacuau guugccaagg cucaucucaa     2640

gcucuugggc ucaagagauc cucccaccuc ggccuccuga guagcuggga cugcaggugu     2700

gugucaucau gaccaaugug aauugcuuuu gaagcugguu caugggcaug uaggccaccg     2760

aagcaauuuu agaccacagu aagucaagcu uuuuucccuc cgaugaucac ugggugguug     2820

cagcauuuuu ugcauaaacc ugccuaagac uugucuaucg ucugugauca auaugccaua     2880

uuacacuaag gugcuccugg aaaauugggu gcaguucaaa uuuuccuaca gcaaaucauu     2940

uggcaaggcc agccauuggg gaaaccagac aacuagagau aacccugaaa ugaauccuuu     3000

uguaaauuga agcaccaucu uuucuuuuuu ugcauaaauu ggagguuuua auuuuagggc     3060

aguuaccuga agugaaauau accaacaauu ucuuguguuc uuuaaauucc uaguuaggug     3120

aauauuuuug aagguccucu uuugaauaaa gaggggaaug gacaccacau uucaggucuu     3180

cucgaagugu ggaagggcaa gagagcauca gugagcugau gguggauugc uuacaucgga     3240

uuccauuggu augaauuucc caaacuggaa aucaaagcgc cagggugggg uuggggcuga     3300

cugcugguga gggggcuggc cgcuggcucc cgugacgugc gucaugggca cgcaggcgcc     3360

auuuugaauc uaucgucggc acgugggugc cauuuugaau ccuuaguugg gccuuucuaa     3420

auggagaaug gcuuuggagg gagacacguu uucugugggg aggguuuggg ggggagggag     3480

gagggaacaa gcuacaugcu auuuuguuug uaguauugug gaacagucuu guuauggagu     3540

gccagcuuag agguuguugc aaacuugucu agaagugaga gcaugguuuu uuuuagcccu     3600

uugagagucu acaucuaaug aacauucuug cucacccaua aauaacguca agccucaaug     3660

ucaccgucac guugggauac ucuuucucau cuggcauccu agacaggaca agguugguua     3720

ccuuuccuuc caugaaccau gaaccuguga cggcaucauu cauccugacu ucaccaagcu     3780

ccgccugugg gugaggccag agcucccacu ggcaauuuuu agaagagcca gaggcucccu     3840

gcuuccucua gaaauaacag uucaggguga agcauggagg guuucaguuc ccagacaaug     3900

gaaccauuua gagacaacac aguuggacau uuccacuuuu uccuugauuc cuggaagucc     3960

aguggguucu gcagcugaaa aagcccuggg ucccagcagc agagagacag gacagagggg     4020

augcuugggc ggggagggac gguaaccugc agaacagauu ccauuuuuau agaacgagua     4080

cacguuugcu aaaacagucc ugcuuuccca gacuggauuc ccaccacagg gacagucgga     4140

acucaggacu agcuccagcg acaucuuucc uccgaauuca agccuucuau cacaauguca     4200

aaacagcuau uuauaaagcc auuuucauug uacuugauaa cagcacgagu cccaaaacuu     4260

uuagaaauaa aauaggacau uggcuugauu gaaaagaggg acuuuuuaaa aauuguucuu     4320

ucgucagaag ccuuuuggau gacuuacaau agcucugaug aagauaccac cccagcguca     4380

guccaauagg ucagugaguu ucaacaggca uccaucccuc ccaugaaggg auucugguga     4440

ugggaaguuu cuguaaugac aggaaagcau ugacccucau ugauugucaa cuuugguauu     4500

agccaugaaa gacaggaugc ucauugggug uucuguagag ugaggaaugc ugccuauucc     4560

cucccagaac gucugaccca ggggugugug uugaggagcc cugggggaaa uggaccaagu     4620

uuucccacag agcaguauua ggcugaagag caggugacug guaggcccca gcucccauca     4680

uucccuccca aagccauuuu guucaguugc ucauccacgc uggauuccag agaguuuucc     4740

aauuugggaa gccaugagaa agguuuuuaa aucuugggaa gauggagaga gggacauagg     4800

auaguugacu ccaacaugac aggaagaggc uggagauugg gaauuggcca ucaaccaagc     4860

cuguaguagu aaagccaugg ucccgcauug gaauuacuug gggaacuuau acaguucuga     4920

uacccaggcu cuccuagacc aguucaacca auucuaggug ggggacucag gcaucagugu     4980

guuucguagc uccccgggug uuuucccugu gcagccgagc uugggaaacu gccaugcuuu     5040

uuggauguca aggcgcuguu ggaggcuggg ugugacagca cagagccagg uugucuugug     5100

gaaaccacag ccacggguuu gccacuggcu cagcauggcc ucacugccag ucccagccug     5160

gcugagggac aagaugguuu cucuugggag uuccugagug gagcacccuu ccaggcuuuu     5220

ugaaagccag cugaucugug gagccuuguu aagggacuca auacgguguu uggauauuga     5280

uguuuuuccu ugagacuguc uuguccauca auaaagaugg aggaugucuc cucuuugaac     5340

cccgcuuccc caccaguacu cucucucccu uagaguuuau gaguuauuca aggaggagac     5400

uucuuaaaga cagcaacgca auucuuguaa cuuguguaaa uagccccauc uuucagagug     5460

auaccauuuc uacauuugau aaugccugua uuccuguagg auguauauag uuuaggggau     5520

uuuuuuuuug uuugguuuug uuuuuuagaa gucaauaugu cugguuuuau uuauugcuug     5580

aaaaagauca uuugaaaaaa auaaauacau uuucaaccac uaaaa                     5625


<210>  8
<211>  394
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Val Thr Met Glu Glu Leu Arg Glu Met Asp Cys Ser Val Leu Lys 
1               5                   10                  15      


Arg Leu Met Asn Arg Asp Glu Asn Gly Gly Gly Ala Gly Gly Ser Gly 
            20                  25                  30          


Ser His Gly Thr Leu Gly Leu Pro Ser Gly Gly Lys Cys Leu Leu Leu 
        35                  40                  45              


Asp Cys Arg Pro Phe Leu Ala His Ser Ala Gly Tyr Ile Leu Gly Ser 
    50                  55                  60                  


Val Asn Val Arg Cys Asn Thr Ile Val Arg Arg Arg Ala Lys Gly Ser 
65                  70                  75                  80  


Val Ser Leu Glu Gln Ile Leu Pro Ala Glu Glu Glu Val Arg Ala Arg 
                85                  90                  95      


Leu Arg Ser Gly Leu Tyr Ser Ala Val Ile Val Tyr Asp Glu Arg Ser 
            100                 105                 110         


Pro Arg Ala Glu Ser Leu Arg Glu Asp Ser Thr Val Ser Leu Val Val 
        115                 120                 125             


Gln Ala Leu Arg Arg Asn Ala Glu Arg Thr Asp Ile Cys Leu Leu Lys 
    130                 135                 140                 


Gly Gly Tyr Glu Arg Phe Ser Ser Glu Tyr Pro Glu Phe Cys Ser Lys 
145                 150                 155                 160 


Thr Lys Ala Leu Ala Ala Ile Pro Pro Pro Val Pro Pro Ser Ala Thr 
                165                 170                 175     


Glu Pro Leu Asp Leu Gly Cys Ser Ser Cys Gly Thr Pro Leu His Asp 
            180                 185                 190         


Gln Gly Gly Pro Val Glu Ile Leu Pro Phe Leu Tyr Leu Gly Ser Ala 
        195                 200                 205             


Tyr His Ala Ala Arg Arg Asp Met Leu Asp Ala Leu Gly Ile Thr Ala 
    210                 215                 220                 


Leu Leu Asn Val Ser Ser Asp Cys Pro Asn His Phe Glu Gly His Tyr 
225                 230                 235                 240 


Gln Tyr Lys Cys Ile Pro Val Glu Asp Asn His Lys Ala Asp Ile Ser 
                245                 250                 255     


Ser Trp Phe Met Glu Ala Ile Glu Tyr Ile Asp Ala Val Lys Asp Cys 
            260                 265                 270         


Arg Gly Arg Val Leu Val His Cys Gln Ala Gly Ile Ser Arg Ser Ala 
        275                 280                 285             


Thr Ile Cys Leu Ala Tyr Leu Met Met Lys Lys Arg Val Arg Leu Glu 
    290                 295                 300                 


Glu Ala Phe Glu Phe Val Lys Gln Arg Arg Ser Ile Ile Ser Pro Asn 
305                 310                 315                 320 


Phe Ser Phe Met Gly Gln Leu Leu Gln Phe Glu Ser Gln Val Leu Ala 
                325                 330                 335     


Thr Ser Cys Ala Ala Glu Ala Ala Ser Pro Ser Gly Pro Leu Arg Glu 
            340                 345                 350         


Arg Gly Lys Thr Pro Ala Thr Pro Thr Ser Gln Phe Val Phe Ser Phe 
        355                 360                 365             


Pro Val Ser Val Gly Val His Ser Ala Pro Ser Ser Leu Pro Tyr Leu 
    370                 375                 380                 


His Ser Pro Ile Thr Thr Ser Pro Ser Cys 
385                 390                 


<210>  9
<211>  2957
<212>  RNA
<213>  Homo sapiens

<400>  9
agggcuuuug ugcaugcuaa uugcgccauu ggugcgcaaa aguuccgacg cgaaguguga       60

acucucaaca gaaggaaaca ugagacaacu gaagugcccu gguuuaugug cccugcuccu      120

ccuccgcugc cgccuccccu ucuuucuccu uccucccgcc gagcccgcug uugcagcuug      180

uuugcacugg ggcuuauccg gagcggaaau uccuuuccgu uuuugugaau gacaaacuca      240

uuaacaauuc aucaacacaa ccuguuccag ccggcccguc cccacggcaa cagccccuuc      300

cgcagcacgc ucauuggcug gcccggagaa uguauccauu gagacgcucg cuguuuguau      360

ccauugagga gcugccucgc gcagggggug ugcgaggcug aguccaagag auagcaaauc      420

gagucuuaaa uaauccgggg agaaagacgc ccggguagau uugaggugca gccuuggagg      480

gagggauuag aagccgcuag acuuuuuuuc cuccccucuc aguagcacgg aguccgaauu      540

aauuggauuu cauucacugg ggaggaacaa aaacuaucug ggcagcuuca uugagagaga      600

uucauugaca cuaagagcca gcggcugcag cugggugcag agagaaccuc cggcuuuacu      660

ucugucucgu cugccccaac cgcuagccuc ggcuugggua aggcgaggcg gaauuaaacc      720

ccgcuccgag agcggcagcu ucgcgcgcgg ugcgcucggc cuaugccugc cccgaggggc      780

gucugguagg caccccgccc ucucccgcag cucgaccccc augauagaua cgcucagacc      840

cgugcccuuc gcgucggaaa uggcgaucag caagacggug gcguggcuca acgagcagcu      900

ggagcugggc aacgagcggc ugcugcugau ggacugccgg ccgcaggagc uauacgaguc      960

gucgcacauc gagucggcca ucaacguggc caucccgggc aucaugcugc ggcgccugca     1020

gaaggguaac cugccggugc gcgcgcucuu cacgcgcggc gaggaccggg accgcuucac     1080

ccggcgcugu ggcaccgaca caguggugcu cuacgacgag agcagcagcg acuggaacga     1140

gaauacgggc ggcgagucgg ugcucgggcu gcugcucaag aagcucaagg acgagggcug     1200

ccgggcguuc uaccuggaag augaagcccg gggcaagaac uguggugucu ugguacauug     1260

cuuggcuggc auuagccgcu cagucacugu gacuguggcu uaccuuaugc agaagcucaa     1320

ucugucgaug aacgaugccu augacauugu caaaaugaaa aaauccaaca uauccccuaa     1380

cuucaacuuc augggucagc ugcuggacuu cgagaggacg cugggacuca gcagcccaug     1440

ugacaacagg guuccagcac agcagcugua uuuuaccacc ccuuccaacc agaauguaua     1500

ccagguggac ucucugcaau cuacgugaaa gaccccacac cccuccuugc uggaaugugu     1560

cuggcccuuc agcaguuucu cuuggcagca ucagcugggc ugcuuucuuu guguguggcc     1620

ccagguguca aaaugacacc agcugucugu acuagacaag guuaccaagu gcggaauugg     1680

uuaauacuaa cagagagauu ugcuccauuc ucuuuggaau aacaggacau gcuguauaga     1740

uacaggcagu agguuugcuc uguacccaug uguacagccu acccaugcag ggacugggau     1800

ucgaggacuu ccaggcgcau aggguagaac caaaugauag gguaggagca uguguucuuu     1860

agggccuugu aaggcuguuu ccuuuugcau cuggaacuga cuauauaauu gucuucaaug     1920

aagacuaauu caauuuugca uauagaggag ccaaagagag auuucagcuc uguauuugug     1980

guaucaguuu ggaaaaaaaa aucugauacu ccauuugauu auuguaaaua uuugaucuug     2040

aaucacuuga caguguuugu uugaauugug uuuguuuuuu ccuuugaugg gcuuaaaaga     2100

aauuauccaa agggagaaag agcaguaugc cacuucuuaa aacagaacaa aacaaaaaaa     2160

gaaaauugug cucuuuucua auccaaaggg uauauuugca gcaugcuuga cuuuaccaau     2220

ucugaugaca ucuuuacgga cacuauuauc acuaagaccu uguuauggcg aagucuuuag     2280

ucuuuuucau guauuuuccu caugauuuuu ucucuuuaug uaguuugacu augccuuacc     2340

uuuguaaaua uuuuugcuug uguugucgca aaggggauaa ucugggaaag acaccaaauc     2400

augggcucac uuuaaaaaaa gaaagaauaa aaaaaccuuc agcugugcua aacaguauau     2460

uaccucugua uaaaauucuu cagggagugu caccucaaau gcaauacuuu ggguugguuu     2520

cuuuccuuua aaaaaauuug uauaaaacug gaagugugug ugugugagca uggguaccca     2580

uuugauaaga gaaaugcauu ugauugugaa gaagggagag uuaaauucuc cauuauguuc     2640

gugguguaaa guuuagagcu ggaauuuauu auaagaaugu aaaaccuuaa auuauuaaua     2700

aauaacuauu uuggcuauug aauguguguu uuuaaaaacu caguuauacc uaugugugaa     2760

gugacacauu uuagaacuuu uucauucagg gauugauuuu gacuuguagg cauaguaggg     2820

caagguucuu uuaagcuuuu ccuagaacgu uuuucagcag caguuuauga aauucaucgu     2880

uugccacgaa uaaagaugac auccuagaau ggaccgacug uaccguguau augaacaaua     2940

ccucuuauga guauagu                                                    2957


<210>  10
<211>  381
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Ile Asp Thr Leu Arg Pro Val Pro Phe Ala Ser Glu Met Ala Ile 
1               5                   10                  15      


Ser Lys Thr Val Ala Trp Leu Asn Glu Gln Leu Glu Leu Gly Asn Glu 
            20                  25                  30          


Arg Leu Leu Leu Met Asp Cys Arg Pro Gln Glu Leu Tyr Glu Ser Ser 
        35                  40                  45              


His Ile Glu Ser Ala Ile Asn Val Ala Ile Pro Gly Ile Met Leu Arg 
    50                  55                  60                  


Arg Leu Gln Lys Gly Asn Leu Pro Val Arg Ala Leu Phe Thr Arg Gly 
65                  70                  75                  80  


Glu Asp Arg Asp Arg Phe Thr Arg Arg Cys Gly Thr Asp Thr Val Val 
                85                  90                  95      


Leu Tyr Asp Glu Ser Ser Ser Asp Trp Asn Glu Asn Thr Gly Gly Glu 
            100                 105                 110         


Ser Val Leu Gly Leu Leu Leu Lys Lys Leu Lys Asp Glu Gly Cys Arg 
        115                 120                 125             


Ala Phe Tyr Leu Glu Gly Gly Phe Ser Lys Phe Gln Ala Glu Phe Ser 
    130                 135                 140                 


Leu His Cys Glu Thr Asn Leu Asp Gly Ser Cys Ser Ser Ser Ser Pro 
145                 150                 155                 160 


Pro Leu Pro Val Leu Gly Leu Gly Gly Leu Arg Ile Ser Ser Asp Ser 
                165                 170                 175     


Ser Ser Asp Ile Glu Ser Asp Leu Asp Arg Asp Pro Asn Ser Ala Thr 
            180                 185                 190         


Asp Ser Asp Gly Ser Pro Leu Ser Asn Ser Gln Pro Ser Phe Pro Val 
        195                 200                 205             


Glu Ile Leu Pro Phe Leu Tyr Leu Gly Cys Ala Lys Asp Ser Thr Asn 
    210                 215                 220                 


Leu Asp Val Leu Glu Glu Phe Gly Ile Lys Tyr Ile Leu Asn Val Thr 
225                 230                 235                 240 


Pro Asn Leu Pro Asn Leu Phe Glu Asn Ala Gly Glu Phe Lys Tyr Lys 
                245                 250                 255     


Gln Ile Pro Ile Ser Asp His Trp Ser Gln Asn Leu Ser Gln Phe Phe 
            260                 265                 270         


Pro Glu Ala Ile Ser Phe Ile Asp Glu Ala Arg Gly Lys Asn Cys Gly 
        275                 280                 285             


Val Leu Val His Cys Leu Ala Gly Ile Ser Arg Ser Val Thr Val Thr 
    290                 295                 300                 


Val Ala Tyr Leu Met Gln Lys Leu Asn Leu Ser Met Asn Asp Ala Tyr 
305                 310                 315                 320 


Asp Ile Val Lys Met Lys Lys Ser Asn Ile Ser Pro Asn Phe Asn Phe 
                325                 330                 335     


Met Gly Gln Leu Leu Asp Phe Glu Arg Thr Leu Gly Leu Ser Ser Pro 
            340                 345                 350         


Cys Asp Asn Arg Val Pro Ala Gln Gln Leu Tyr Phe Thr Thr Pro Ser 
        355                 360                 365             


Asn Gln Asn Val Tyr Gln Val Asp Ser Leu Gln Ser Thr 
    370                 375                 380     


<210>  11
<211>  4304
<212>  RNA
<213>  Homo sapiens

<400>  11
cacacggacu acaggggagu uuuguugaag uugcaaaguc cuggagccuc cagagggcug       60

ucggcgcagu agcagcgagc agcagagucc gcacgcuccg gcgaggggca gaagagcgcg      120

agggagcgcg gggcagcaga agcgagagcc gagcgcggac ccagccagga cccacagccc      180

uccccagcug cccaggaaga gccccagcca uggaacacca gcuccugugc ugcgaagugg      240

aaaccauccg ccgcgcguac cccgaugcca accuccucaa cgaccgggug cugcgggcca      300

ugcugaaggc ggaggagacc ugcgcgcccu cgguguccua cuucaaaugu gugcagaagg      360

agguccugcc guccaugcgg aagaucgucg ccaccuggau gcuggagguc ugcgaggaac      420

agaagugcga ggaggagguc uucccgcugg ccaugaacua ccuggaccgc uuccugucgc      480

uggagcccgu gaaaaagagc cgccugcagc ugcugggggc cacuugcaug uucguggccu      540

cuaagaugaa ggagaccauc ccccugacgg ccgagaagcu gugcaucuac accgacaacu      600

ccauccggcc cgaggagcug cugcaaaugg agcugcuccu ggugaacaag cucaagugga      660

accuggccgc aaugaccccg cacgauuuca uugaacacuu ccucuccaaa augccagagg      720

cggaggagaa caaacagauc auccgcaaac acgcgcagac cuucguugcc cucugugcca      780

cagaugugaa guucauuucc aauccgcccu ccaugguggc agcggggagc gugguggccg      840

cagugcaagg ccugaaccug aggagcccca acaacuuccu guccuacuac cgccucacac      900

gcuuccucuc cagagugauc aagugugacc cggacugccu ccgggccugc caggagcaga      960

ucgaagcccu gcuggaguca agccugcgcc aggcccagca gaacauggac cccaaggccg     1020

ccgaggagga ggaagaggag gaggaggagg uggaccuggc uugcacaccc accgacgugc     1080

gggacgugga caucugaggg cgccaggcag gcgggcgcca ccgccacccg cagcgagggc     1140

ggagccggcc ccaggugcuc cccugacagu cccuccucuc cggagcauuu ugauaccaga     1200

agggaaagcu ucauucuccu uguuguuggu uguuuuuucc uuugcucuuu cccccuucca     1260

ucucugacuu aagcaaaaga aaaagauuac ccaaaaacug ucuuuaaaag agagagagag     1320

aaaaaaaaaa uaguauuugc auaacccuga gcgguggggg aggaggguug ugcuacagau     1380

gauagaggau uuuauacccc aauaaucaac ucguuuuuau auuaauguac uuguuucucu     1440

guuguaagaa uaggcauuaa cacaaaggag gcgucucggg agaggauuag guuccauccu     1500

uuacguguuu aaaaaaaagc auaaaaacau uuuaaaaaca uagaaaaauu cagcaaacca     1560

uuuuuaaagu agaagagggu uuuagguaga aaaacauauu cuugugcuuu uccugauaaa     1620

gcacagcugu agugggguuc uaggcaucuc uguacuuugc uugcucauau gcauguaguc     1680

acuuuauaag ucauuguaug uuauuauauu ccguagguag auguguaacc ucuucaccuu     1740

auucauggcu gaagucaccu cuugguuaca guagcguagc gugcccgugu gcauguccuu     1800

ugcgccugug accaccaccc caacaaacca uccagugaca aaccauccag uggagguuug     1860

ucgggcacca gccagcguag cagggucggg aaaggccacc ugucccacuc cuacgauacg     1920

cuacuauaaa gagaagacga aauagugaca uaauauauuc uauuuuuaua cucuuccuau     1980

uuuuguagug accuguuuau gagaugcugg uuuucuaccc aacggcccug cagccagcuc     2040

acguccaggu ucaacccaca gcuacuuggu uuguguucuu cuucauauuc uaaaaccauu     2100

ccauuuccaa gcacuuucag uccaauaggu guaggaaaua gcgcuguuuu uguugugugu     2160

gcagggaggg caguuuucua auggaauggu uugggaauau ccauguacuu guuugcaagc     2220

aggacuuuga ggcaagugug ggccacugug guggcagugg agguggggug uuugggaggc     2280

ugcgugccag ucaagaagaa aaagguuugc auucucacau ugccaggaug auaaguuccu     2340

uuccuuuucu uuaaagaagu ugaaguuuag gaauccuuug gugccaacug guguuugaaa     2400

guagggaccu cagagguuua ccuagagaac aggugguuuu uaaggguuau cuuagauguu     2460

ucacaccgga agguuuuuaa acacuaaaau auauaauuua uaguuaaggc uaaaaaguau     2520

auuuauugca gaggauguuc auaaggccag uaugauuuau aaaugcaauc uccccuugau     2580

uuaaacacac agauacacac acacacacac acacacacaa accuucugcc uuugauguua     2640

cagauuuaau acaguuuauu uuuaaagaua gauccuuuua uaggugagaa aaaaacaauc     2700

uggaagaaaa aaaccacaca aagacauuga uucagccugu uuggcguuuc ccagagucau     2760

cugauuggac aggcaugggu gcaaggaaaa uuaggguacu caaccuaagu ucgguuccga     2820

ugaauucuua uccccugccc cuuccuuuaa aaaacuuagu gacaaaauag acaauuugca     2880

caucuuggcu auguaauucu uguaauuuuu auuuaggaag uguugaaggg agguggcaag     2940

aguguggagg cugacgugug agggaggaca ggcgggagga ggugugagga ggaggcuccc     3000

gaggggaagg ggcggugccc acaccgggga caggccgcag cuccauuuuc uuauugcgcu     3060

gcuaccguug acuuccaggc acgguuugga aauauucaca ucgcuucugu guaucucuuu     3120

cacauuguuu gcugcuauug gaggaucagu uuuuuguuuu acaaugucau auacugccau     3180

guacuaguuu uaguuuucuc uuagaacauu guauuacaga ugccuuuuuu guaguuuuuu     3240

uuuuuuuuau gugaucaauu uugacuuaau gugauuacug cucuauucca aaaagguugc     3300

uguuucacaa uaccucaugc uucacuuagc caugguggac ccagcgggca gguucugccu     3360

gcuuuggcgg gcagacacgc gggcgcgauc ccacacaggc uggcgggggc cggccccgag     3420

gccgcgugcg ugagaaccgc gccggugucc ccagagacca ggcugugucc cucuucucuu     3480

cccugcgccu gugaugcugg gcacuucauc ugaucggggg cguagcauca uaguaguuuu     3540

uacagcugug uuauucuuug cguguagcua uggaaguugc auaauuauua uuauuauuau     3600

uauaacaagu gugucuuacg ugccaccacg gcguuguacc uguaggacuc ucauucggga     3660

ugauuggaau agcuucugga auuuguucaa guuuugggua uguuuaaucu guuauguacu     3720

aguguucugu uuguuauugu uuuguuaauu acaccauaau gcuaauuuaa agagacucca     3780

aaucucaaug aagccagcuc acagugcugu gugccccggu caccuagcaa gcugccgaac     3840

caaaagaauu ugcaccccgc ugcgggccca cgugguuggg gcccugcccu ggcaggguca     3900

uccugugcuc ggaggccauc ucgggcacag gcccaccccg ccccaccccu ccagaacacg     3960

gcucacgcuu accucaacca uccuggcugc ggcgucuguc ugaaccacgc gggggccuug     4020

agggacgcuu ugucugucgu gauggggcaa gggcacaagu ccuggauguu guguguaucg     4080

agaggccaaa ggcugguggc aagugcacgg ggcacagcgg agucuguccu gugacgcgca     4140

agucugaggg ucugggcggc gggcggcugg gucugugcau uucugguugc accgcggcgc     4200

uucccagcac caacauguaa ccggcauguu uccagcagaa gacaaaaaga caaacaugaa     4260

agucuagaaa uaaaacuggu aaaaccccaa aaaaaaaaaa aaaa                      4304


<210>  12
<211>  295
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Glu His Gln Leu Leu Cys Cys Glu Val Glu Thr Ile Arg Arg Ala 
1               5                   10                  15      


Tyr Pro Asp Ala Asn Leu Leu Asn Asp Arg Val Leu Arg Ala Met Leu 
            20                  25                  30          


Lys Ala Glu Glu Thr Cys Ala Pro Ser Val Ser Tyr Phe Lys Cys Val 
        35                  40                  45              


Gln Lys Glu Val Leu Pro Ser Met Arg Lys Ile Val Ala Thr Trp Met 
    50                  55                  60                  


Leu Glu Val Cys Glu Glu Gln Lys Cys Glu Glu Glu Val Phe Pro Leu 
65                  70                  75                  80  


Ala Met Asn Tyr Leu Asp Arg Phe Leu Ser Leu Glu Pro Val Lys Lys 
                85                  90                  95      


Ser Arg Leu Gln Leu Leu Gly Ala Thr Cys Met Phe Val Ala Ser Lys 
            100                 105                 110         


Met Lys Glu Thr Ile Pro Leu Thr Ala Glu Lys Leu Cys Ile Tyr Thr 
        115                 120                 125             


Asp Asn Ser Ile Arg Pro Glu Glu Leu Leu Gln Met Glu Leu Leu Leu 
    130                 135                 140                 


Val Asn Lys Leu Lys Trp Asn Leu Ala Ala Met Thr Pro His Asp Phe 
145                 150                 155                 160 


Ile Glu His Phe Leu Ser Lys Met Pro Glu Ala Glu Glu Asn Lys Gln 
                165                 170                 175     


Ile Ile Arg Lys His Ala Gln Thr Phe Val Ala Leu Cys Ala Thr Asp 
            180                 185                 190         


Val Lys Phe Ile Ser Asn Pro Pro Ser Met Val Ala Ala Gly Ser Val 
        195                 200                 205             


Val Ala Ala Val Gln Gly Leu Asn Leu Arg Ser Pro Asn Asn Phe Leu 
    210                 215                 220                 


Ser Tyr Tyr Arg Leu Thr Arg Phe Leu Ser Arg Val Ile Lys Cys Asp 
225                 230                 235                 240 


Pro Asp Cys Leu Arg Ala Cys Gln Glu Gln Ile Glu Ala Leu Leu Glu 
                245                 250                 255     


Ser Ser Leu Arg Gln Ala Gln Gln Asn Met Asp Pro Lys Ala Ala Glu 
            260                 265                 270         


Glu Glu Glu Glu Glu Glu Glu Glu Val Asp Leu Ala Cys Thr Pro Thr 
        275                 280                 285             


Asp Val Arg Asp Val Asp Ile 
    290                 295 


<210>  13
<211>  3970
<212>  RNA
<213>  Homo sapiens

<400>  13
gguucucacc caacuuccau uaaggacucg gggcaggagg ggcagaaguu gcgcgcaggc       60

cggcgggcgg gagcggacac cgaggccggc gugcaggcgu gcgggugugc gggagccggg      120

cucgggggga ucggaccgag agcgagaagc gcggcaugga gcuccaggca gcccgcgccu      180

gcuucgcccu gcuguggggc ugugcgcugg ccgcggccgc ggcggcgcag ggcaaggaag      240

ugguacugcu ggacuuugcu gcagcuggag gggagcucgg cuggcucaca cacccguaug      300

gcaaagggug ggaccugaug cagaacauca ugaaugacau gccgaucuac auguacuccg      360

ugugcaacgu gaugucuggc gaccaggaca acuggcuccg caccaacugg guguaccgag      420

gagaggcuga gcguaucuuc auugagcuca aguuuacugu acgugacugc aacagcuucc      480

cugguggcgc cagcuccugc aaggagacuu ucaaccucua cuaugccgag ucggaccugg      540

acuacggcac caacuuccag aagcgccugu ucaccaagau ugacaccauu gcgcccgaug      600

agaucaccgu cagcagcgac uucgaggcac gccacgugaa gcugaacgug gaggagcgcu      660

ccguggggcc gcucacccgc aaaggcuucu accuggccuu ccaggauauc ggugccugug      720

uggcgcugcu cuccguccgu gucuacuaca agaagugccc cgagcugcug cagggccugg      780

cccacuuccc ugagaccauc gccggcucug augcaccuuc ccuggccacu guggccggca      840

ccugugugga ccaugccgug gugccaccgg ggggugaaga gccccguaug cacugugcag      900

uggauggcga guggcuggug cccauugggc agugccugug ccaggcaggc uacgagaagg      960

uggaggaugc cugccaggcc ugcucgccug gauuuuuuaa guuugaggca ucugagagcc     1020

ccugcuugga gugcccugag cacacgcugc cauccccuga gggugccacc uccugcgagu     1080

gugaggaagg cuucuuccgg gcaccucagg acccagcguc gaugccuugc acacgacccc     1140

ccuccgcccc acacuaccuc acagccgugg gcaugggugc caagguggag cugcgcugga     1200

cgcccccuca ggacagcggg ggccgcgagg acauugucua cagcgucacc ugcgaacagu     1260

gcuggcccga gucuggggaa ugcgggccgu gugaggccag ugugcgcuac ucggagccuc     1320

cucacggacu gacccgcacc agugugacag ugagcgaccu ggagccccac augaacuaca     1380

ccuucaccgu ggaggcccgc aauggcgucu caggccuggu aaccagccgc agcuuccgua     1440

cugccagugu cagcaucaac cagacagagc cccccaaggu gaggcuggag ggccgcagca     1500

ccaccucgcu uagcgucucc uggagcaucc ccccgccgca gcagagccga guguggaagu     1560

acgaggucac uuaccgcaag aagggagacu ccaacagcua caaugugcgc cgcaccgagg     1620

guuucuccgu gacccuggac gaccuggccc cagacaccac cuaccugguc caggugcagg     1680

cacugacgca ggagggccag ggggccggca gcaaggugca cgaauuccag acgcuguccc     1740

cggagggauc uggcaacuug gcggugauug gcggcguggc ugucggugug guccugcuuc     1800

uggugcuggc aggaguuggc uucuuuaucc accgcaggag gaagaaccag cgugcccgcc     1860

aguccccgga ggacguuuac uucuccaagu cagaacaacu gaagccccug aagacauacg     1920

uggaccccca cacauaugag gaccccaacc aggcuguguu gaaguucacu accgagaucc     1980

auccauccug ugucacucgg cagaagguga ucggagcagg agaguuuggg gagguguaca     2040

agggcaugcu gaagacaucc ucggggaaga aggaggugcc gguggccauc aagacgcuga     2100

aagccggcua cacagagaag cagcgagugg acuuccucgg cgaggccggc aucaugggcc     2160

aguucagcca ccacaacauc auccgccuag agggcgucau cuccaaauac aagcccauga     2220

ugaucaucac ugaguacaug gagaaugggg cccuggacaa guuccuucgg gagaaggaug     2280

gcgaguucag cgugcugcag cuggugggca ugcugcgggg caucgcagcu ggcaugaagu     2340

accuggccaa caugaacuau gugcaccgug accuggcugc ccgcaacauc cucgucaaca     2400

gcaaccuggu cugcaaggug ucugacuuug gccugucccg cgugcuggag gacgaccccg     2460

aggccaccua caccaccagu ggcggcaaga uccccauccg cuggaccgcc ccggaggcca     2520

uuuccuaccg gaaguucacc ucugccagcg acguguggag cuuuggcauu gucauguggg     2580

aggugaugac cuauggcgag cggcccuacu gggaguuguc caaccacgag gugaugaaag     2640

ccaucaauga uggcuuccgg cuccccacac ccauggacug ccccuccgcc aucuaccagc     2700

ucaugaugca gugcuggcag caggagcgug cccgccgccc caaguucgcu gacaucguca     2760

gcauccugga caagcucauu cgugccccug acucccucaa gacccuggcu gacuuugacc     2820

cccgcguguc uauccggcuc cccagcacga gcggcucgga gggggugccc uuccgcacgg     2880

uguccgagug gcuggagucc aucaagaugc agcaguauac ggagcacuuc auggcggccg     2940

gcuacacugc caucgagaag guggugcaga ugaccaacga cgacaucaag aggauugggg     3000

ugcggcugcc cggccaccag aagcgcaucg ccuacagccu gcugggacuc aaggaccagg     3060

ugaacacugu ggggaucccc aucugagccu cgacagggcc uggagcccca ucggccaaga     3120

auacuugaag aaacagagug gccucccugc ugugccaugc ugggccacug gggacuuuau     3180

uuauuucuag uucuuuccuc ccccugcaac uuccgcugag gggucucgga ugacacccug     3240

gccugaacug aggagaugac cagggaugcu gggcugggcc cucuuucccu gcgagacgca     3300

cacagcugag cacuuagcag gcaccgccac gucccagcau cccuggagca ggagccccgc     3360

cacagccuuc ggacagacau augggauauu cccaagccga ccuucccucc gccuucuccc     3420

acaugaggcc aucucaggag auggagggcu uggcccagcg ccaaguaaac aggguaccuc     3480

aagccccauu uccucacacu aagagggcag acugugaacu ugacugggug agacccaaag     3540

cggucccugu cccucuagug ccuucuuuag acccucgggc cccauccuca ucccugacug     3600

gccaaacccu ugcuuuccug ggccuuugca agaugcuugg uuguguugag guuuuuaaau     3660

auauauuuug uacuuugugg agagaaugug uguguguggc agggggcccc gccagggcug     3720

gggacagagg gugucaaaca uucgugagcu ggggacucag ggaccggugc ugcaggagug     3780

uccugcccau gccccagucg gccccaucuc ucauccuuuu ggauaaguuu cuauucuguc     3840

aguguuaaag auuuuguuuu guuggacauu uuuuucgaau cuuaauuuau uauuuuuuuu     3900

auauuuauug uuagaaaaug acuuauuucu gcucuggaau aaaguugcag augauucaaa     3960

ccgaaaaaaa                                                            3970


<210>  14
<211>  976
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Glu Leu Gln Ala Ala Arg Ala Cys Phe Ala Leu Leu Trp Gly Cys 
1               5                   10                  15      


Ala Leu Ala Ala Ala Ala Ala Ala Gln Gly Lys Glu Val Val Leu Leu 
            20                  25                  30          


Asp Phe Ala Ala Ala Gly Gly Glu Leu Gly Trp Leu Thr His Pro Tyr 
        35                  40                  45              


Gly Lys Gly Trp Asp Leu Met Gln Asn Ile Met Asn Asp Met Pro Ile 
    50                  55                  60                  


Tyr Met Tyr Ser Val Cys Asn Val Met Ser Gly Asp Gln Asp Asn Trp 
65                  70                  75                  80  


Leu Arg Thr Asn Trp Val Tyr Arg Gly Glu Ala Glu Arg Ile Phe Ile 
                85                  90                  95      


Glu Leu Lys Phe Thr Val Arg Asp Cys Asn Ser Phe Pro Gly Gly Ala 
            100                 105                 110         


Ser Ser Cys Lys Glu Thr Phe Asn Leu Tyr Tyr Ala Glu Ser Asp Leu 
        115                 120                 125             


Asp Tyr Gly Thr Asn Phe Gln Lys Arg Leu Phe Thr Lys Ile Asp Thr 
    130                 135                 140                 


Ile Ala Pro Asp Glu Ile Thr Val Ser Ser Asp Phe Glu Ala Arg His 
145                 150                 155                 160 


Val Lys Leu Asn Val Glu Glu Arg Ser Val Gly Pro Leu Thr Arg Lys 
                165                 170                 175     


Gly Phe Tyr Leu Ala Phe Gln Asp Ile Gly Ala Cys Val Ala Leu Leu 
            180                 185                 190         


Ser Val Arg Val Tyr Tyr Lys Lys Cys Pro Glu Leu Leu Gln Gly Leu 
        195                 200                 205             


Ala His Phe Pro Glu Thr Ile Ala Gly Ser Asp Ala Pro Ser Leu Ala 
    210                 215                 220                 


Thr Val Ala Gly Thr Cys Val Asp His Ala Val Val Pro Pro Gly Gly 
225                 230                 235                 240 


Glu Glu Pro Arg Met His Cys Ala Val Asp Gly Glu Trp Leu Val Pro 
                245                 250                 255     


Ile Gly Gln Cys Leu Cys Gln Ala Gly Tyr Glu Lys Val Glu Asp Ala 
            260                 265                 270         


Cys Gln Ala Cys Ser Pro Gly Phe Phe Lys Phe Glu Ala Ser Glu Ser 
        275                 280                 285             


Pro Cys Leu Glu Cys Pro Glu His Thr Leu Pro Ser Pro Glu Gly Ala 
    290                 295                 300                 


Thr Ser Cys Glu Cys Glu Glu Gly Phe Phe Arg Ala Pro Gln Asp Pro 
305                 310                 315                 320 


Ala Ser Met Pro Cys Thr Arg Pro Pro Ser Ala Pro His Tyr Leu Thr 
                325                 330                 335     


Ala Val Gly Met Gly Ala Lys Val Glu Leu Arg Trp Thr Pro Pro Gln 
            340                 345                 350         


Asp Ser Gly Gly Arg Glu Asp Ile Val Tyr Ser Val Thr Cys Glu Gln 
        355                 360                 365             


Cys Trp Pro Glu Ser Gly Glu Cys Gly Pro Cys Glu Ala Ser Val Arg 
    370                 375                 380                 


Tyr Ser Glu Pro Pro His Gly Leu Thr Arg Thr Ser Val Thr Val Ser 
385                 390                 395                 400 


Asp Leu Glu Pro His Met Asn Tyr Thr Phe Thr Val Glu Ala Arg Asn 
                405                 410                 415     


Gly Val Ser Gly Leu Val Thr Ser Arg Ser Phe Arg Thr Ala Ser Val 
            420                 425                 430         


Ser Ile Asn Gln Thr Glu Pro Pro Lys Val Arg Leu Glu Gly Arg Ser 
        435                 440                 445             


Thr Thr Ser Leu Ser Val Ser Trp Ser Ile Pro Pro Pro Gln Gln Ser 
    450                 455                 460                 


Arg Val Trp Lys Tyr Glu Val Thr Tyr Arg Lys Lys Gly Asp Ser Asn 
465                 470                 475                 480 


Ser Tyr Asn Val Arg Arg Thr Glu Gly Phe Ser Val Thr Leu Asp Asp 
                485                 490                 495     


Leu Ala Pro Asp Thr Thr Tyr Leu Val Gln Val Gln Ala Leu Thr Gln 
            500                 505                 510         


Glu Gly Gln Gly Ala Gly Ser Lys Val His Glu Phe Gln Thr Leu Ser 
        515                 520                 525             


Pro Glu Gly Ser Gly Asn Leu Ala Val Ile Gly Gly Val Ala Val Gly 
    530                 535                 540                 


Val Val Leu Leu Leu Val Leu Ala Gly Val Gly Phe Phe Ile His Arg 
545                 550                 555                 560 


Arg Arg Lys Asn Gln Arg Ala Arg Gln Ser Pro Glu Asp Val Tyr Phe 
                565                 570                 575     


Ser Lys Ser Glu Gln Leu Lys Pro Leu Lys Thr Tyr Val Asp Pro His 
            580                 585                 590         


Thr Tyr Glu Asp Pro Asn Gln Ala Val Leu Lys Phe Thr Thr Glu Ile 
        595                 600                 605             


His Pro Ser Cys Val Thr Arg Gln Lys Val Ile Gly Ala Gly Glu Phe 
    610                 615                 620                 


Gly Glu Val Tyr Lys Gly Met Leu Lys Thr Ser Ser Gly Lys Lys Glu 
625                 630                 635                 640 


Val Pro Val Ala Ile Lys Thr Leu Lys Ala Gly Tyr Thr Glu Lys Gln 
                645                 650                 655     


Arg Val Asp Phe Leu Gly Glu Ala Gly Ile Met Gly Gln Phe Ser His 
            660                 665                 670         


His Asn Ile Ile Arg Leu Glu Gly Val Ile Ser Lys Tyr Lys Pro Met 
        675                 680                 685             


Met Ile Ile Thr Glu Tyr Met Glu Asn Gly Ala Leu Asp Lys Phe Leu 
    690                 695                 700                 


Arg Glu Lys Asp Gly Glu Phe Ser Val Leu Gln Leu Val Gly Met Leu 
705                 710                 715                 720 


Arg Gly Ile Ala Ala Gly Met Lys Tyr Leu Ala Asn Met Asn Tyr Val 
                725                 730                 735     


His Arg Asp Leu Ala Ala Arg Asn Ile Leu Val Asn Ser Asn Leu Val 
            740                 745                 750         


Cys Lys Val Ser Asp Phe Gly Leu Ser Arg Val Leu Glu Asp Asp Pro 
        755                 760                 765             


Glu Ala Thr Tyr Thr Thr Ser Gly Gly Lys Ile Pro Ile Arg Trp Thr 
    770                 775                 780                 


Ala Pro Glu Ala Ile Ser Tyr Arg Lys Phe Thr Ser Ala Ser Asp Val 
785                 790                 795                 800 


Trp Ser Phe Gly Ile Val Met Trp Glu Val Met Thr Tyr Gly Glu Arg 
                805                 810                 815     


Pro Tyr Trp Glu Leu Ser Asn His Glu Val Met Lys Ala Ile Asn Asp 
            820                 825                 830         


Gly Phe Arg Leu Pro Thr Pro Met Asp Cys Pro Ser Ala Ile Tyr Gln 
        835                 840                 845             


Leu Met Met Gln Cys Trp Gln Gln Glu Arg Ala Arg Arg Pro Lys Phe 
    850                 855                 860                 


Ala Asp Ile Val Ser Ile Leu Asp Lys Leu Ile Arg Ala Pro Asp Ser 
865                 870                 875                 880 


Leu Lys Thr Leu Ala Asp Phe Asp Pro Arg Val Ser Ile Arg Leu Pro 
                885                 890                 895     


Ser Thr Ser Gly Ser Glu Gly Val Pro Phe Arg Thr Val Ser Glu Trp 
            900                 905                 910         


Leu Glu Ser Ile Lys Met Gln Gln Tyr Thr Glu His Phe Met Ala Ala 
        915                 920                 925             


Gly Tyr Thr Ala Ile Glu Lys Val Val Gln Met Thr Asn Asp Asp Ile 
    930                 935                 940                 


Lys Arg Ile Gly Val Arg Leu Pro Gly His Gln Lys Arg Ile Ala Tyr 
945                 950                 955                 960 


Ser Leu Leu Gly Leu Lys Asp Gln Val Asn Thr Val Gly Ile Pro Ile 
                965                 970                 975     


<210>  15
<211>  6597
<212>  RNA
<213>  Homo sapiens

<400>  15
acgcgugcuc aucuugugua aaaguaaaag uugcucaugu cauuagcucg gcucugaguu       60

ugcaugagaa accagcgcag cucucgagcc acgggagaaa acacgaucug cugcggagcc      120

cagugaccug aaacuguagc agugacucga gaccuguccu cuccucgacg ucgcccuaua      180

acccucccgc uuuauuuagg auccgcuuuu ccgagagcag ccacucaggc aacccccgga      240

agaagcggca ggagcagcgu uggcaccggc gaaccauggc ugggauuuuc uauuucgccc      300

uauuuucgug ucucuucggg auuugcgacg cugucacagg uuccagggua uaccccgcga      360

augaaguuac cuuauuggau uccagaucug uucagggaga acuugggugg auagcaagcc      420

cucuggaagg agggugggag gaagugagua ucauggauga aaaaaauaca ccaauccgaa      480

ccuaccaagu gugcaaugug auggaaccca gccagaauaa cuggcuacga acugauugga      540

ucacccgaga aggggcucag aggguguaua uugagauuaa auucaccuug agggacugca      600

auagucuucc gggcgucaug gggacuugca aggagacguu uaaccuguac uacuaugaau      660

cagacaacga caaagagcgu uucaucagag agaaccaguu ugucaaaauu gacaccauug      720

cugcugauga gagcuucacc caaguggaca uuggugacag aaucaugaag cugaacaccg      780

agauccggga uguagggcca uuaagcaaaa agggguuuua ccuggcuuuu caggaugugg      840

gggccugcau cgcccuggua ucaguccgug uguucuauaa aaagugucca cucacagucc      900

gcaaucuggc ccaguuuccu gacaccauca caggggcuga uacgucuucc cugguggaag      960

uucgaggcuc cugugucaac aacucagaag agaaagaugu gccaaaaaug uacugugggg     1020

cagaugguga auggcuggua cccauuggca acugccuaug caacgcuggg caugaggagc     1080

ggagcggaga augccaagcu ugcaaaauug gauauuacaa ggcucucucc acggaugcca     1140

ccugugccaa gugcccaccc cacagcuacu cugucuggga aggagccacc ucgugcaccu     1200

gugaccgagg cuuuuucaga gcugacaacg augcugccuc uaugcccugc acccguccac     1260

caucugcucc ccugaacuug auuucaaaug ucaacgagac aucugugaac uuggaaugga     1320

guagcccuca gaauacaggu ggccgccagg acauuuccua uaauguggua ugcaagaaau     1380

guggagcugg ugaccccagc aagugccgac ccuguggaag ugggguccac uacaccccac     1440

agcagaaugg cuugaagacc accaaagucu ccaucacuga ccuccuagcu cauaccaauu     1500

acaccuuuga aaucugggcu gugaauggag uguccaaaua uaacccuaac ccagaccaau     1560

caguuucugu cacugugacc accaaccaag cagcaccauc auccauugcu uugguccagg     1620

cuaaagaagu cacaagauac aguguggcac uggcuuggcu ggaaccagau cggcccaaug     1680

ggguaauccu ggaauaugaa gucaaguauu augagaagga ucagaaugag cgaagcuauc     1740

guauaguucg gacagcugcc aggaacacag auaucaaagg ccugaacccu cucacuuccu     1800

auguuuucca cgugcgagcc aggacagcag cuggcuaugg agacuucagu gagcccuugg     1860

agguuacaac caacacagug ccuucccgga ucauuggaga uggggcuaac uccacagucc     1920

uucuggucuc ugucucgggc aguguggugc uggugguaau ucucauugca gcuuuuguca     1980

ucagccggag acggaguaaa uacaguaaag ccaaacaaga agcggaugaa gagaaacauu     2040

ugaaucaagg uguaagaaca uauguggacc ccuuuacgua cgaagauccc aaccaagcag     2100

ugcgagaguu ugccaaagaa auugacgcau ccugcauuaa gauugaaaaa guuauaggag     2160

uuggugaauu uggugaggua ugcagugggc gucucaaagu gccuggcaag agagagaucu     2220

guguggcuau caagacucug aaagcugguu auacagacaa acagaggaga gacuuccuga     2280

gugaggccag caucauggga caguuugacc auccgaacau cauucacuug gaaggcgugg     2340

ucacuaaaug uaaaccagua augaucauaa cagaguacau ggagaauggc uccuuggaug     2400

cauuccucag gaaaaaugau ggcagauuua cagucauuca gcuggugggc augcuucgug     2460

gcauuggguc ugggaugaag uauuuaucug auaugagcua ugugcaucgu gaucuggccg     2520

cacggaacau ccuggugaac agcaacuugg ucugcaaagu gucugauuuu ggcauguccc     2580

gagugcuuga ggaugauccg gaagcagcuu acaccaccag ggguggcaag auuccuaucc     2640

gguggacugc gccagaagca auugccuauc guaaauucac aucagcaagu gauguaugga     2700

gcuauggaau cguuaugugg gaagugaugu cguacgggga gaggcccuau ugggauaugu     2760

ccaaucaaga ugugauuaaa gccauugagg aaggcuaucg guuacccccu ccaauggacu     2820

gccccauugc gcuccaccag cugaugcuag acugcuggca gaaggagagg agcgacaggc     2880

cuaaauuugg gcagauuguc aacauguugg acaaacucau ccgcaacccc aacagcuuga     2940

agaggacagg gacggagagc uccagaccua acacugccuu guuggaucca agcuccccug     3000

aauucucugc ugugguauca gugggcgauu ggcuccaggc cauuaaaaug gaccgguaua     3060

aggauaacuu cacagcugcu gguuauacca cacuagaggc uguggugcac gugaaccagg     3120

aggaccuggc aagaauuggu aucacagcca ucacgcacca gaauaagauu uugagcagug     3180

uccaggcaau gcgaacccaa augcagcaga ugcacggcag aaugguuccc gucugagcca     3240

guacugaaua aacucaaaac ucuugaaauu aguuuaccuc auccaugcac uuuaauugaa     3300

gaacugcacu uuuuuuacuu cgucuucgcc cucugaaauu aaagaaauga aaaaaaaaaa     3360

caauaucugc agcguugcuu ggugcacaga uugcugaaac uguggggcuu acagaaauga     3420

cugccgguca uuugaaugag accuggaaca aaucguuucu cagaaguacu uuucuguuca     3480

ucaccagucu guaaaauaca uguaccuaua gaaauagaac acugccucug aguuuugaug     3540

cuguauuugc ugccagacac ugagcuucug agacaucccu gauucucucu ccauuuggaa     3600

uuacaaccau uguauuuugu uuguggcaua aauuacaguc aucugucuuu cacuggaaug     3660

aagaccaugc cuaggaacau uuuuuaagga cucagcugug gcuuuuaggg cuugguucau     3720

accauggggg aaaaaaaagu ccuaggagaa agcgacgugg cucauuagug uugccucuuc     3780

agugcucaag ccgccuggug gauuccuaug acacaggggg ccuggaaaga aagggaaagu     3840

ggauuuaaaa uauauauaua cguaacccaa gccccauaac cccuaacugg acaaaugagg     3900

ucuguuucuu ugggccugag gcugugccau auaaagucuu auuuugggac uuuacaaacu     3960

uguccuaacu aucuugugga uagugggcug ugacaaucug gaauagagaa cguucacacu     4020

ucgcuccuuu aaagaagcga ccccagaucu gcaagggagu agauucugcu aucuuggccu     4080

cacagcccuu ccuguugauu acaaagcccg uggaagaaaa cagaacacac ccuccucagu     4140

uccgucuaaa uguguuucuu cugcuucaau uacaccaguu cuggggcaaa gacacugaug     4200

aaacaacacc cauaccugaa aagaauaaau gugugacuuu caaauccccu uucgcaguga     4260

aagaaacagc aaacacuuaa gauucagcau cuguucucca guugcacuga ggaaugcacu     4320

gucucgcagc accagcucug cagagcccuu gccccagacu cuuugcgguu uuauuuauau     4380

guauuuccau auuucauucc ugugugucac ugcugcauug guguggcagc aagugaccaa     4440

augcuacagg ucuuacuaug gacaccaggu caggugcaac cacacaaaac aaagccaguu     4500

ccaugagcug ccuaugauau gcauugcgga aguaacauuu uacccagggu gugccauugc     4560

agugauauaa auauauuuuu uucuuagacu aaauaugagc ugacuaucuc uuuugaugug     4620

uguacauagg ugugagugug ucuguaugcg ugccugucug ugugcgggug uguguaugug     4680

cguagccuca ugcuuaggac uacccaugaa uguuguggaa ugcuacaccu ggagaguucu     4740

gguuuuccac caguuucaag augaagaacu acaugauaca guggaccugg agaccauccc     4800

cuuggaaaga caacccagag auguucagca uccuguaucu acacgcaucc uguaucuaca     4860

cguguauuuu guagcuguca cacuaaccuu aauaagaauu cuacagcuuu ggacagaggc     4920

auuuucaccu uaauggugaa guaauuuaaa auauaaaucc auucagguga caacccauca     4980

ucaaaauuac aaauuuucug auugaacuca ucugaaucau caguuccuug auggagagag     5040

agaaggagau ggaauguguc ugguaacccc aaauggagua caaguagccu uuguuuuccu     5100

gcauaaaugg acuuguugaa ugcgaacgaa uauaugcaau ucauauacuu uuggagauga     5160

acguagauau gugugucagc uuugagaugg uguguccugg auuaauacuu ugucucccaa     5220

uaucacagaa aaauacaugc cagugacucu ugagguuaag guaguuggga ugaaauggcc     5280

ucaggcaauu ucacauuccc uaauuaccug gaaaguucua caguaauuaa uaugcagcua     5340

acuccuguug cccucacaag agcaucagcc uucuagaauc ggagcuccgg agugugaaga     5400

uucaguauug auaugauaug uauaccaaac uccagccaac uuacugccau uuuucauaau     5460

cugaguggcu gccuugcuua uccuaagcug ugguugcaga aaccguggcc auuuauauaa     5520

gcuauaacau caaaucaggg aaaaaugagg aaaaaaaaua gauucugaac cauuuauugu     5580

ugaauaagua gagaaaauca ucaauaaaua uuuauuacau ucugacaggg uguguggcau     5640

uguguucuau gccagaguga caaaguugau ucaccccuuu uuggggaccu uaauauauuu     5700

uuuaagggau gugccuaugc auugaugccu gaaaaauaug uauaaagaaa ugagguugac     5760

ucuucugagc aguucaucuu uuccagaggu aaggguagga ggccaacuuc agggucuggg     5820

ucugagcccg ugggcaagcc cuggccgagu gagcuccaau gcuaacucau gugccgaucu     5880

cuagagcagu gggaaacuac cccgcugcac caaaucaagu agcuucaccu uguguaugca     5940

ggccccaagu uauuuuuuag caaucuuacg agugaaaugu ucuggugggu ugaaaaacgu     6000

ucuuauuuua aagaaagguu gugcucgcua cacugcuggu gugugcauuc ugagaccucu     6060

uguauucaau cugugaagga uauguguauu aauccguaca cccguauagc cucaauauuu     6120

gucugaagac acuuaaauuc ugacccauaa aggaaaguuc uagaagcaau auuuucacuu     6180

auuuaacauu cuccaaacaa caucaagcau ugauacacac ugaagagugc guuuauuuuu     6240

uguaucacuc uaaguauguu ggaauaugca aggacugugg uucaaauuag aauguauaag     6300

gcauauuaua auuuaguuca uacugaauaa gaaauuaaca gaacauuguu cgguucacac     6360

guuccaaacu uugagugauu ucuggaguua gacauagauu uucuauuuug uuuuaauuug     6420

ucaagguauu uuucuucccu ucaugaacuu uagguacaca uaacuuaugu cauuuauuua     6480

uggucuuuua uaccuaguuu guaaaauugu aaaauagcaa acuaaaugca aagaguuugc     6540

auuugaaaau aauaaaguag uugccguaua caacccugca aaaaaaaaaa aaaaaaa        6597


<210>  16
<211>  986
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Ala Gly Ile Phe Tyr Phe Ala Leu Phe Ser Cys Leu Phe Gly Ile 
1               5                   10                  15      


Cys Asp Ala Val Thr Gly Ser Arg Val Tyr Pro Ala Asn Glu Val Thr 
            20                  25                  30          


Leu Leu Asp Ser Arg Ser Val Gln Gly Glu Leu Gly Trp Ile Ala Ser 
        35                  40                  45              


Pro Leu Glu Gly Gly Trp Glu Glu Val Ser Ile Met Asp Glu Lys Asn 
    50                  55                  60                  


Thr Pro Ile Arg Thr Tyr Gln Val Cys Asn Val Met Glu Pro Ser Gln 
65                  70                  75                  80  


Asn Asn Trp Leu Arg Thr Asp Trp Ile Thr Arg Glu Gly Ala Gln Arg 
                85                  90                  95      


Val Tyr Ile Glu Ile Lys Phe Thr Leu Arg Asp Cys Asn Ser Leu Pro 
            100                 105                 110         


Gly Val Met Gly Thr Cys Lys Glu Thr Phe Asn Leu Tyr Tyr Tyr Glu 
        115                 120                 125             


Ser Asp Asn Asp Lys Glu Arg Phe Ile Arg Glu Asn Gln Phe Val Lys 
    130                 135                 140                 


Ile Asp Thr Ile Ala Ala Asp Glu Ser Phe Thr Gln Val Asp Ile Gly 
145                 150                 155                 160 


Asp Arg Ile Met Lys Leu Asn Thr Glu Ile Arg Asp Val Gly Pro Leu 
                165                 170                 175     


Ser Lys Lys Gly Phe Tyr Leu Ala Phe Gln Asp Val Gly Ala Cys Ile 
            180                 185                 190         


Ala Leu Val Ser Val Arg Val Phe Tyr Lys Lys Cys Pro Leu Thr Val 
        195                 200                 205             


Arg Asn Leu Ala Gln Phe Pro Asp Thr Ile Thr Gly Ala Asp Thr Ser 
    210                 215                 220                 


Ser Leu Val Glu Val Arg Gly Ser Cys Val Asn Asn Ser Glu Glu Lys 
225                 230                 235                 240 


Asp Val Pro Lys Met Tyr Cys Gly Ala Asp Gly Glu Trp Leu Val Pro 
                245                 250                 255     


Ile Gly Asn Cys Leu Cys Asn Ala Gly His Glu Glu Arg Ser Gly Glu 
            260                 265                 270         


Cys Gln Ala Cys Lys Ile Gly Tyr Tyr Lys Ala Leu Ser Thr Asp Ala 
        275                 280                 285             


Thr Cys Ala Lys Cys Pro Pro His Ser Tyr Ser Val Trp Glu Gly Ala 
    290                 295                 300                 


Thr Ser Cys Thr Cys Asp Arg Gly Phe Phe Arg Ala Asp Asn Asp Ala 
305                 310                 315                 320 


Ala Ser Met Pro Cys Thr Arg Pro Pro Ser Ala Pro Leu Asn Leu Ile 
                325                 330                 335     


Ser Asn Val Asn Glu Thr Ser Val Asn Leu Glu Trp Ser Ser Pro Gln 
            340                 345                 350         


Asn Thr Gly Gly Arg Gln Asp Ile Ser Tyr Asn Val Val Cys Lys Lys 
        355                 360                 365             


Cys Gly Ala Gly Asp Pro Ser Lys Cys Arg Pro Cys Gly Ser Gly Val 
    370                 375                 380                 


His Tyr Thr Pro Gln Gln Asn Gly Leu Lys Thr Thr Lys Val Ser Ile 
385                 390                 395                 400 


Thr Asp Leu Leu Ala His Thr Asn Tyr Thr Phe Glu Ile Trp Ala Val 
                405                 410                 415     


Asn Gly Val Ser Lys Tyr Asn Pro Asn Pro Asp Gln Ser Val Ser Val 
            420                 425                 430         


Thr Val Thr Thr Asn Gln Ala Ala Pro Ser Ser Ile Ala Leu Val Gln 
        435                 440                 445             


Ala Lys Glu Val Thr Arg Tyr Ser Val Ala Leu Ala Trp Leu Glu Pro 
    450                 455                 460                 


Asp Arg Pro Asn Gly Val Ile Leu Glu Tyr Glu Val Lys Tyr Tyr Glu 
465                 470                 475                 480 


Lys Asp Gln Asn Glu Arg Ser Tyr Arg Ile Val Arg Thr Ala Ala Arg 
                485                 490                 495     


Asn Thr Asp Ile Lys Gly Leu Asn Pro Leu Thr Ser Tyr Val Phe His 
            500                 505                 510         


Val Arg Ala Arg Thr Ala Ala Gly Tyr Gly Asp Phe Ser Glu Pro Leu 
        515                 520                 525             


Glu Val Thr Thr Asn Thr Val Pro Ser Arg Ile Ile Gly Asp Gly Ala 
    530                 535                 540                 


Asn Ser Thr Val Leu Leu Val Ser Val Ser Gly Ser Val Val Leu Val 
545                 550                 555                 560 


Val Ile Leu Ile Ala Ala Phe Val Ile Ser Arg Arg Arg Ser Lys Tyr 
                565                 570                 575     


Ser Lys Ala Lys Gln Glu Ala Asp Glu Glu Lys His Leu Asn Gln Gly 
            580                 585                 590         


Val Arg Thr Tyr Val Asp Pro Phe Thr Tyr Glu Asp Pro Asn Gln Ala 
        595                 600                 605             


Val Arg Glu Phe Ala Lys Glu Ile Asp Ala Ser Cys Ile Lys Ile Glu 
    610                 615                 620                 


Lys Val Ile Gly Val Gly Glu Phe Gly Glu Val Cys Ser Gly Arg Leu 
625                 630                 635                 640 


Lys Val Pro Gly Lys Arg Glu Ile Cys Val Ala Ile Lys Thr Leu Lys 
                645                 650                 655     


Ala Gly Tyr Thr Asp Lys Gln Arg Arg Asp Phe Leu Ser Glu Ala Ser 
            660                 665                 670         


Ile Met Gly Gln Phe Asp His Pro Asn Ile Ile His Leu Glu Gly Val 
        675                 680                 685             


Val Thr Lys Cys Lys Pro Val Met Ile Ile Thr Glu Tyr Met Glu Asn 
    690                 695                 700                 


Gly Ser Leu Asp Ala Phe Leu Arg Lys Asn Asp Gly Arg Phe Thr Val 
705                 710                 715                 720 


Ile Gln Leu Val Gly Met Leu Arg Gly Ile Gly Ser Gly Met Lys Tyr 
                725                 730                 735     


Leu Ser Asp Met Ser Tyr Val His Arg Asp Leu Ala Ala Arg Asn Ile 
            740                 745                 750         


Leu Val Asn Ser Asn Leu Val Cys Lys Val Ser Asp Phe Gly Met Ser 
        755                 760                 765             


Arg Val Leu Glu Asp Asp Pro Glu Ala Ala Tyr Thr Thr Arg Gly Gly 
    770                 775                 780                 


Lys Ile Pro Ile Arg Trp Thr Ala Pro Glu Ala Ile Ala Tyr Arg Lys 
785                 790                 795                 800 


Phe Thr Ser Ala Ser Asp Val Trp Ser Tyr Gly Ile Val Met Trp Glu 
                805                 810                 815     


Val Met Ser Tyr Gly Glu Arg Pro Tyr Trp Asp Met Ser Asn Gln Asp 
            820                 825                 830         


Val Ile Lys Ala Ile Glu Glu Gly Tyr Arg Leu Pro Pro Pro Met Asp 
        835                 840                 845             


Cys Pro Ile Ala Leu His Gln Leu Met Leu Asp Cys Trp Gln Lys Glu 
    850                 855                 860                 


Arg Ser Asp Arg Pro Lys Phe Gly Gln Ile Val Asn Met Leu Asp Lys 
865                 870                 875                 880 


Leu Ile Arg Asn Pro Asn Ser Leu Lys Arg Thr Gly Thr Glu Ser Ser 
                885                 890                 895     


Arg Pro Asn Thr Ala Leu Leu Asp Pro Ser Ser Pro Glu Phe Ser Ala 
            900                 905                 910         


Val Val Ser Val Gly Asp Trp Leu Gln Ala Ile Lys Met Asp Arg Tyr 
        915                 920                 925             


Lys Asp Asn Phe Thr Ala Ala Gly Tyr Thr Thr Leu Glu Ala Val Val 
    930                 935                 940                 


His Val Asn Gln Glu Asp Leu Ala Arg Ile Gly Ile Thr Ala Ile Thr 
945                 950                 955                 960 


His Gln Asn Lys Ile Leu Ser Ser Val Gln Ala Met Arg Thr Gln Met 
                965                 970                 975     


Gln Gln Met His Gly Arg Met Val Pro Val 
            980                 985     


<210>  17
<211>  2358
<212>  RNA
<213>  Homo sapiens

<400>  17
gaaacaaagg gaaacggggg gcgguguggc ggggcggggg guggagagcu gaggccgagc       60

gaaggaaaug caccaaucag cugcuccccc gggcucacaa cugucugcug cgcccgaaaa      120

acaagucggu gcgcugggga cccggggccg gggccgccuu acuccggccu agccccgcgg      180

cccucggugc gggcuccagg gcaugcucgg gaccccccgc ggcuccagcc cagacgcccc      240

ggccucagaa aucgcccgga aaugggagcu ugcgcgaagc gcugaucggc ccgcugggga      300

agcucaugga cccgggcucc cugccgcccc ucgacucuga agaucucuuc caggaucuaa      360

gucacuucca ggagacgugg cucgcugaag cucagguacc agacagugau gagcaguuug      420

uuccugauuu ccauucagaa aaccuagcuu uccacagccc caccaccagg aucaagaagg      480

agccccagag uccccgcaca gacccggccc uguccugcag caggaagccg ccacuccccu      540

accaccaugg cgagcagugc cuuuacucca gugccuauga cccccccaga caaaucgcca      600

ucaagucccc ugccccuggu gcccuuggac agucgccccu acagcccuuu ccccgggcag      660

agcaacggaa uuuccugaga uccucuggca ccucccagcc ccacccuggc cauggguacc      720

ucggggaaca uagcuccguc uuccagcagc cccuggacau uugccacucc uucacaucuc      780

agggaggggg ccgggaaccc cucccagccc ccuaccaaca ccagcugucg gagcccugcc      840

cacccuaucc ccagcagagc uuuaagcaag aauaccauga uccccuguau gaacaggcgg      900

gccagccagc cguggaccag ggugggguca augggcacag guacccaggg gcgggggugg      960

ugaucaaaca ggaacagacg gacuucgccu acgacucaga ugucaccggg ugcgcaucaa     1020

uguaccucca cacagagggc uucucugggc ccucuccagg ugacggggcc augggcuaug     1080

gcuaugagaa accucugcga ccauucccag augaugucug cguugucccu gagaaauuug     1140

aaggagacau caagcaggaa ggggucggug cauuucgaga ggggccgccc uaccagcgcc     1200

ggggugcccu gcagcugugg caauuucugg uggccuugcu ggaugaccca acaaaugccc     1260

auuucauugc cuggacgggc cggggaaugg aguucaagcu cauugagccu gaggaggucg     1320

ccaggcucug gggcauccag aagaaccggc cagccaugaa uuacgacaag cugagccgcu     1380

cgcuccgaua cuauuaugag aaaggcauca ugcagaaggu ggcuggugag cguuacgugu     1440

acaaguuugu gugugagccc gaggcccucu ucucuuuggc cuucccggac aaucagcguc     1500

cagcucucaa ggcugaguuu gaccggccug ucagugagga ggacacaguc ccuuuguccc     1560

acuuggauga gagccccgcc uaccucccag agcuggcugg ccccgcccag ccauuuggcc     1620

ccaagggugg cuacucuuac uagcccccag cggcuguucc cccugccgca ggugggugcu     1680

gcccugugua cauauaaaug aaucuggugu uggggaaacc uucaucugaa acccacagau     1740

gucucugggg cagaucccca cuguccuacc aguugcccua gcccagacuc ugagcugcuc     1800

accggaguca uugggaagga aaaguggaga aauggcaagu cuagagucuc agaaacuccc     1860

cuggggguuu caccugggcc cuggaggaau ucagcucagc uucuuccuag guccaagccc     1920

cccacaccuu uuccccaacc acagagaaca agaguuuguu cuguucuggg ggacagagaa     1980

ggcgcuuccc aacuucauac uggcaggagg gugaggaggu ucacugagcu ccccagaucu     2040

cccacugcgg ggagacagaa gccuggacuc ugccccacgc uguggcccug gagggucccg     2100

guuugucagu ucuuggugcu cuguguuccc agaggcaggc ggagguugaa gaaaggaacc     2160

ugggaugagg ggugcugggu auaagcagag agggaugggu uccugcucca agggacccuu     2220

ugccuuucuu cugcccuuuc cuaggcccag gccuggguuu guacuuccac cuccaccaca     2280

ucugccagac cuuaauaaag gcccccacuu cucccauuaa aaaaaaaaaa aaaaaaaaaa     2340

aaaaaaaaaa aaaaaaaa                                                   2358


<210>  18
<211>  484
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Glu Arg Arg Met Lys Ala Gly Tyr Leu Asp Gln Gln Val Pro Tyr 
1               5                   10                  15      


Thr Phe Ser Ser Lys Ser Pro Gly Asn Gly Ser Leu Arg Glu Ala Leu 
            20                  25                  30          


Ile Gly Pro Leu Gly Lys Leu Met Asp Pro Gly Ser Leu Pro Pro Leu 
        35                  40                  45              


Asp Ser Glu Asp Leu Phe Gln Asp Leu Ser His Phe Gln Glu Thr Trp 
    50                  55                  60                  


Leu Ala Glu Ala Gln Val Pro Asp Ser Asp Glu Gln Phe Val Pro Asp 
65                  70                  75                  80  


Phe His Ser Glu Asn Leu Ala Phe His Ser Pro Thr Thr Arg Ile Lys 
                85                  90                  95      


Lys Glu Pro Gln Ser Pro Arg Thr Asp Pro Ala Leu Ser Cys Ser Arg 
            100                 105                 110         


Lys Pro Pro Leu Pro Tyr His His Gly Glu Gln Cys Leu Tyr Ser Ser 
        115                 120                 125             


Ala Tyr Asp Pro Pro Arg Gln Ile Ala Ile Lys Ser Pro Ala Pro Gly 
    130                 135                 140                 


Ala Leu Gly Gln Ser Pro Leu Gln Pro Phe Pro Arg Ala Glu Gln Arg 
145                 150                 155                 160 


Asn Phe Leu Arg Ser Ser Gly Thr Ser Gln Pro His Pro Gly His Gly 
                165                 170                 175     


Tyr Leu Gly Glu His Ser Ser Val Phe Gln Gln Pro Leu Asp Ile Cys 
            180                 185                 190         


His Ser Phe Thr Ser Gln Gly Gly Gly Arg Glu Pro Leu Pro Ala Pro 
        195                 200                 205             


Tyr Gln His Gln Leu Ser Glu Pro Cys Pro Pro Tyr Pro Gln Gln Ser 
    210                 215                 220                 


Phe Lys Gln Glu Tyr His Asp Pro Leu Tyr Glu Gln Ala Gly Gln Pro 
225                 230                 235                 240 


Ala Val Asp Gln Gly Gly Val Asn Gly His Arg Tyr Pro Gly Ala Gly 
                245                 250                 255     


Val Val Ile Lys Gln Glu Gln Thr Asp Phe Ala Tyr Asp Ser Asp Val 
            260                 265                 270         


Thr Gly Cys Ala Ser Met Tyr Leu His Thr Glu Gly Phe Ser Gly Pro 
        275                 280                 285             


Ser Pro Gly Asp Gly Ala Met Gly Tyr Gly Tyr Glu Lys Pro Leu Arg 
    290                 295                 300                 


Pro Phe Pro Asp Asp Val Cys Val Val Pro Glu Lys Phe Glu Gly Asp 
305                 310                 315                 320 


Ile Lys Gln Glu Gly Val Gly Ala Phe Arg Glu Gly Pro Pro Tyr Gln 
                325                 330                 335     


Arg Arg Gly Ala Leu Gln Leu Trp Gln Phe Leu Val Ala Leu Leu Asp 
            340                 345                 350         


Asp Pro Thr Asn Ala His Phe Ile Ala Trp Thr Gly Arg Gly Met Glu 
        355                 360                 365             


Phe Lys Leu Ile Glu Pro Glu Glu Val Ala Arg Leu Trp Gly Ile Gln 
    370                 375                 380                 


Lys Asn Arg Pro Ala Met Asn Tyr Asp Lys Leu Ser Arg Ser Leu Arg 
385                 390                 395                 400 


Tyr Tyr Tyr Glu Lys Gly Ile Met Gln Lys Val Ala Gly Glu Arg Tyr 
                405                 410                 415     


Val Tyr Lys Phe Val Cys Glu Pro Glu Ala Leu Phe Ser Leu Ala Phe 
            420                 425                 430         


Pro Asp Asn Gln Arg Pro Ala Leu Lys Ala Glu Phe Asp Arg Pro Val 
        435                 440                 445             


Ser Glu Glu Asp Thr Val Pro Leu Ser His Leu Asp Glu Ser Pro Ala 
    450                 455                 460                 


Tyr Leu Pro Glu Leu Ala Gly Pro Ala Gln Pro Phe Gly Pro Lys Gly 
465                 470                 475                 480 


Gly Tyr Ser Tyr 
                


<210>  19
<211>  4102
<212>  RNA
<213>  Homo sapiens

<400>  19
agccugguug gcagcugcgg cgcagagucc agccgcuggu gcgcggagcg guucaccguc       60

uucggagcgg uucggcccag ccuuucgccc aggcgcccag gcccgcugcg cgcgugcgug      120

agcgcgccug cgccgccggg gccgcugcaa ggggaggaga gaggccgccu caggaggauc      180

ccuuuucccc cagaaauuac ucaaugcuga aaccucucaa agugguauua gagacgcuga      240

aagcaccaug gacggguuuu augaucagca agucccuuuu auggucccag ggaaaucucg      300

aucugaggaa ugcagagggc ggccugugau ugacagaaag aggaaguuuu uggacacaga      360

ucuggcucac gauucugaag agcuauuuca ggaucucagu caacuucaag aggcuugguu      420

agcugaagca caaguuccug augaugaaca guuuguccca gauuuucagu cugauaaccu      480

ggugcuucau gccccaccuc caaccaagau caaacgggag cugcacagcc ccuccucuga      540

gcugucgucu uguagccaug agcaggcucu uggugcuaac uauggagaaa agugccucua      600

caacuauugu gccuaugaua ggaagccucc cucuggguuc aagccauuaa ccccuccuac      660

aaccccccuc ucacccaccc aucagaaucc ccuauuuccc ccaccucagg caacucugcc      720

caccucaggg caugccccug cagcuggccc aguucaaggu gugggccccg cccccgcccc      780

ccauucgcuu ccagagccug gaccacagca gcaaacauuu gcgguccccc gaccaccaca      840

ucagccccug cagaugccaa agaugaugcc ugaaaaccag uauccaucag aacagagauu      900

ucagagacaa cugucugaac ccugccaccc cuucccuccu cagccaggag uuccuggaga      960

uaaucgcccc aguuaccauc ggcaaauguc agaaccuauu gucccugcag cucccccgcc     1020

cccucaggga uucaaacaag aauaccauga cccacucuau gaacaugggg ucccgggcau     1080

gccagggccc ccagcacacg gguuccaguc accaauggga aucaagcagg agccucggga     1140

uuacugcguc gauucagaag ugccuaacug ccagucaucc uacaugagag gggguuauuu     1200

cuccagcagc caugaagguu uuucauauga aaaagauccc cgauuauacu uugacgacac     1260

uuguguugug ccugagagac uggaaggcaa agucaaacag gagccuacca uguaucgaga     1320

ggggcccccu uaccagaggc gagguucccu ucagcugugg caguuccugg ucacccuucu     1380

ugaugaccca gccaaugccc acuucauugc cuggacaggu cgaggcaugg aguucaagcu     1440

gauagaaccg gaagagguug cucggcgcug gggcauccag aagaaccggc cagccaugaa     1500

cuaugacaag cugagccgcu cucuccgcua uuacuaugaa aagggcauca ugcagaaggu     1560

ggcuggagag cgauacgucu acaaauuugu cugugaccca gaugcccucu ucuccauggc     1620

uuucccggau aaccagcguc cguuccugaa ggcagagucc gagugccacc ucagcgagga     1680

ggacacccug ccgcugaccc acuuugaaga cagccccgcu uaccuccugg acauggaccg     1740

cugcagcagc cuccccuaug ccgaaggcuu ugcuuacuaa guuucugagu ggcggagugg     1800

ccaaacccua gagcuagcag uucccauuca ggcaaacaag ggcagugguu uuguuugugu     1860

uuuugguugu uccuaaagcu ugcccuuuga guauuaucug gagaacccaa gcugucucug     1920

gauuggcacc cuuaaagaca gauacauugg cuggggagug ggaacaggga ggggcagaaa     1980

accaccaaaa ggccagugcc ucaacucuug auucugauga gguuucuggg aagagaucaa     2040

aauggagucu ccuuaccaug gacaauacau gcaaagcaau aucuuguuca gguuaguacc     2100

cgcaaaacgg gacauaguau gugacaaucu gcaucgauca uggacuacua aaugccuuua     2160

cauagaaggg cucugauuug cacaauuugu ugaaaaauca caaacccaua gaaaaguaag     2220

uaggcuaagu uggggaggcu caaaccauua aggguuaaaa auacaucuua aacauuggaa     2280

agcucuucua gcugaaucug aaauauuacc ccuugucuag aaaaaggggg gcagucagaa     2340

cagcuguucc ccacuccgug guucucaaaa ucauaaacca uggcuacucu ugggaaccac     2400

ccggccaugu ggucgccaag uagagcaagc ccccuuucuc uucccaauca cguggcugag     2460

uguggaugac uuuuauuuua ggagaagggc gauuaacacu uuugacagua uuuuguuuug     2520

cccugauuug ggggauuguu uuguuuuggu gguuguuuug gaaaaacagu uuauaaacug     2580

auuuuuguag uuuugguauu uaaagcaaaa aaacgaaaaa caaaaaacaa aaacaaaccu     2640

uuugguaacu gugcacugug uccuuuagcc agggccgugc caacuuauga agacacugca     2700

gcuugagagg ggcuuugcug aggcuucccc uuggccaugu gaaagcccgc cuuguugccu     2760

gcuuugugcu uucugcacca gacaaccuga uggaacauuu gcaccugagu uguacauuuu     2820

ugaagugugc agggcagccu ggacacaagc uuagauucuc uauguauagu uccccguguu     2880

cacuaacaug cccucucugg aaagcauaug uauauaacau gugucauguc cuuuggaaac     2940

cuggucaccu ggugaaaacc cuugggauuc uucccugggc augacugaug acaauuucca     3000

uuucaucagu uuguuuuguu uuccuuuuuc uuuaaaucuu ggacuuuaaa cccuaccugu     3060

gugauucagu aggguuugag acuuacgugu gauacugaca gguaagcaac agugcuagca     3120

uucuagauuc cugccuuuuu uuaaaaagaa auuauucuca uugcuguauu auauuggaaa     3180

aguuuuaaac aaccaagcua aagcuaugug aaaguugagc ucaaaguaga ggaaaaguua     3240

cuggugguac cuugcugccu gcucugcugg uagaauucug ugcuccccgu gacacuuagu     3300

acauuaagaa ugacuacacu guuccucgua ugugaaggag gcagugcuga cuccgugagu     3360

gugagacacg ugcuuugaac ugcuuuucua uucauggagc acuccauagu cucaaacugu     3420

cccccuuaug accaacagca cauuugugaa gagguucgca gggauaaggg gugcacuuua     3480

uagcuaugga aacaugagau ucuccucuau uggaagcuaa uuagcccaca aaggugguaa     3540

accuguagau ugggccuuaa uuagcauugu acucuaauca aaggacucuu ucuaaaccau     3600

auuuauagcu uucuuaaccu acacauaguc uauacauaga ugcauauuuu acccccagcu     3660

ggcuagagau uuauuuguug uaaaugcugu auagauuugg uuuuccuuuc uuuacuuacc     3720

cugguuugga uuuuuuuuuu uuuucuuuug aauggauuua ugcugucuua gcaauaugac     3780

aauaauccuc uguagcuuga gcuaccccuc cccugcugua acuuacguga ccugugcugu     3840

cacugggcau aggacagcgg caucacgguu gcauucccau uggacucaug caccucccgg     3900

augguuuuug uuuuuuucgg ggguucuuug ggguuuguuu guuugcuucu uuuccagagu     3960

guggaaaguc uacagugcag aaaggcuuga accugccagc ugauuugaaa uacuuucccc     4020

ugcgcagggc cguaugcauc cugccaagcu gcguuauauu cuguacugug uacaauaaag     4080

aaguuugcuu uucguuuacc aa                                              4102


<210>  20
<211>  510
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Asp Gly Phe Tyr Asp Gln Gln Val Pro Phe Met Val Pro Gly Lys 
1               5                   10                  15      


Ser Arg Ser Glu Glu Cys Arg Gly Arg Pro Val Ile Asp Arg Lys Arg 
            20                  25                  30          


Lys Phe Leu Asp Thr Asp Leu Ala His Asp Ser Glu Glu Leu Phe Gln 
        35                  40                  45              


Asp Leu Ser Gln Leu Gln Glu Ala Trp Leu Ala Glu Ala Gln Val Pro 
    50                  55                  60                  


Asp Asp Glu Gln Phe Val Pro Asp Phe Gln Ser Asp Asn Leu Val Leu 
65                  70                  75                  80  


His Ala Pro Pro Pro Thr Lys Ile Lys Arg Glu Leu His Ser Pro Ser 
                85                  90                  95      


Ser Glu Leu Ser Ser Cys Ser His Glu Gln Ala Leu Gly Ala Asn Tyr 
            100                 105                 110         


Gly Glu Lys Cys Leu Tyr Asn Tyr Cys Ala Tyr Asp Arg Lys Pro Pro 
        115                 120                 125             


Ser Gly Phe Lys Pro Leu Thr Pro Pro Thr Thr Pro Leu Ser Pro Thr 
    130                 135                 140                 


His Gln Asn Pro Leu Phe Pro Pro Pro Gln Ala Thr Leu Pro Thr Ser 
145                 150                 155                 160 


Gly His Ala Pro Ala Ala Gly Pro Val Gln Gly Val Gly Pro Ala Pro 
                165                 170                 175     


Ala Pro His Ser Leu Pro Glu Pro Gly Pro Gln Gln Gln Thr Phe Ala 
            180                 185                 190         


Val Pro Arg Pro Pro His Gln Pro Leu Gln Met Pro Lys Met Met Pro 
        195                 200                 205             


Glu Asn Gln Tyr Pro Ser Glu Gln Arg Phe Gln Arg Gln Leu Ser Glu 
    210                 215                 220                 


Pro Cys His Pro Phe Pro Pro Gln Pro Gly Val Pro Gly Asp Asn Arg 
225                 230                 235                 240 


Pro Ser Tyr His Arg Gln Met Ser Glu Pro Ile Val Pro Ala Ala Pro 
                245                 250                 255     


Pro Pro Pro Gln Gly Phe Lys Gln Glu Tyr His Asp Pro Leu Tyr Glu 
            260                 265                 270         


His Gly Val Pro Gly Met Pro Gly Pro Pro Ala His Gly Phe Gln Ser 
        275                 280                 285             


Pro Met Gly Ile Lys Gln Glu Pro Arg Asp Tyr Cys Val Asp Ser Glu 
    290                 295                 300                 


Val Pro Asn Cys Gln Ser Ser Tyr Met Arg Gly Gly Tyr Phe Ser Ser 
305                 310                 315                 320 


Ser His Glu Gly Phe Ser Tyr Glu Lys Asp Pro Arg Leu Tyr Phe Asp 
                325                 330                 335     


Asp Thr Cys Val Val Pro Glu Arg Leu Glu Gly Lys Val Lys Gln Glu 
            340                 345                 350         


Pro Thr Met Tyr Arg Glu Gly Pro Pro Tyr Gln Arg Arg Gly Ser Leu 
        355                 360                 365             


Gln Leu Trp Gln Phe Leu Val Thr Leu Leu Asp Asp Pro Ala Asn Ala 
    370                 375                 380                 


His Phe Ile Ala Trp Thr Gly Arg Gly Met Glu Phe Lys Leu Ile Glu 
385                 390                 395                 400 


Pro Glu Glu Val Ala Arg Arg Trp Gly Ile Gln Lys Asn Arg Pro Ala 
                405                 410                 415     


Met Asn Tyr Asp Lys Leu Ser Arg Ser Leu Arg Tyr Tyr Tyr Glu Lys 
            420                 425                 430         


Gly Ile Met Gln Lys Val Ala Gly Glu Arg Tyr Val Tyr Lys Phe Val 
        435                 440                 445             


Cys Asp Pro Asp Ala Leu Phe Ser Met Ala Phe Pro Asp Asn Gln Arg 
    450                 455                 460                 


Pro Phe Leu Lys Ala Glu Ser Glu Cys His Leu Ser Glu Glu Asp Thr 
465                 470                 475                 480 


Leu Pro Leu Thr His Phe Glu Asp Ser Pro Ala Tyr Leu Leu Asp Met 
                485                 490                 495     


Asp Arg Cys Ser Ser Leu Pro Tyr Ala Glu Gly Phe Ala Tyr 
            500                 505                 510 


