                         SEQUENCE LISTING

<110>  GREIF, Hagar
       FELDMAN, Anat
 
<120>  METHYLMALONYL COENZYME A MUTASE (MCM) FUSION CONSTRUCTS FOR THE 
       TREATMENT OF DISORDERS ASSOCIATED WITH MCM DEFICIENCY

<130>  BIOB-008/001WO 322146-2121

<150>  US 62/321,359
<151>  2016-04-12

<160>  23    

<170>  PatentIn version 3.5

<210>  1
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1

His His His His His His 
1               5       


<210>  2
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2

Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg 
1               5                   10      


<210>  3
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  3

Arg Lys Lys Arg Arg Gln Arg Arg Arg 
1               5                   


<210>  4
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  4

Ala Leu Leu Thr Ala Ala Ala Arg Leu Leu Gly Thr Lys Asn Ala Ser 
1               5                   10                  15      


Cys Leu Val Leu Ala Ala Arg His Ala Ser 
            20                  25      


<210>  5
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  5

Met Leu Arg Ala Lys Asn Gln Leu Phe Leu Leu Ser Pro His Tyr Leu 
1               5                   10                  15      


Arg Gln Val Lys Glu Ser Ser Gly Ser Arg Leu Ile Gln Gln Arg Leu 
            20                  25                  30          


<210>  6
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  6

Gln Ser Trp Ser Arg Val Tyr Cys Ser Leu Ala Lys Arg Gly His Phe 
1               5                   10                  15      


Asn Arg Ile Ser His Gly Leu Gln Gly Leu Ser Ala Val Pro Leu Arg 
            20                  25                  30          


Thr Tyr Ala 
        35  


<210>  7
<211>  367
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  7

Met Lys Ile Glu Glu Gly Lys Leu Val Ile Trp Ile Asn Gly Asp Lys 
1               5                   10                  15      


Gly Tyr Asn Gly Leu Ala Glu Val Gly Lys Lys Phe Glu Lys Asp Thr 
            20                  25                  30          


Gly Ile Lys Val Thr Val Glu His Pro Asp Lys Leu Glu Glu Lys Phe 
        35                  40                  45              


Pro Gln Val Ala Ala Thr Gly Asp Gly Pro Asp Ile Ile Phe Trp Ala 
    50                  55                  60                  


His Asp Arg Phe Gly Gly Tyr Ala Gln Ser Gly Leu Leu Ala Glu Ile 
65                  70                  75                  80  


Thr Pro Asp Lys Ala Phe Gln Asp Lys Leu Tyr Pro Phe Thr Trp Asp 
                85                  90                  95      


Ala Val Arg Tyr Asn Gly Lys Leu Ile Ala Tyr Pro Ile Ala Val Glu 
            100                 105                 110         


Ala Leu Ser Leu Ile Tyr Asn Lys Asp Leu Leu Pro Asn Pro Pro Lys 
        115                 120                 125             


Thr Trp Glu Glu Ile Pro Ala Leu Asp Lys Glu Leu Lys Ala Lys Gly 
    130                 135                 140                 


Lys Ser Ala Leu Met Phe Asn Leu Gln Glu Pro Tyr Phe Thr Trp Pro 
145                 150                 155                 160 


Leu Ile Ala Ala Asp Gly Gly Tyr Ala Phe Lys Tyr Glu Asn Gly Lys 
                165                 170                 175     


Tyr Asp Ile Lys Asp Val Gly Val Asp Asn Ala Gly Ala Lys Ala Gly 
            180                 185                 190         


Leu Thr Phe Leu Val Asp Leu Ile Lys Asn Lys His Met Asn Ala Asp 
        195                 200                 205             


Thr Asp Tyr Ser Ile Ala Glu Ala Ala Phe Asn Lys Gly Glu Thr Ala 
    210                 215                 220                 


Met Thr Ile Asn Gly Pro Trp Ala Trp Ser Asn Ile Asp Thr Ser Lys 
225                 230                 235                 240 


Val Asn Tyr Gly Val Thr Val Leu Pro Thr Phe Lys Gly Gln Pro Ser 
                245                 250                 255     


Lys Pro Phe Val Gly Val Leu Ser Ala Gly Ile Asn Ala Ala Ser Pro 
            260                 265                 270         


Asn Lys Glu Leu Ala Lys Glu Phe Leu Glu Asn Tyr Leu Leu Thr Asp 
        275                 280                 285             


Glu Gly Leu Glu Ala Val Asn Lys Asp Lys Pro Leu Gly Ala Val Ala 
    290                 295                 300                 


Leu Lys Ser Tyr Glu Glu Glu Leu Ala Lys Asp Pro Arg Ile Ala Ala 
305                 310                 315                 320 


Thr Met Glu Asn Ala Gln Lys Gly Glu Ile Met Pro Asn Ile Pro Gln 
                325                 330                 335     


Met Ser Ala Phe Trp Tyr Ala Val Arg Thr Ala Val Ile Asn Ala Ala 
            340                 345                 350         


Ser Gly Arg Gln Thr Val Asp Glu Ala Leu Lys Asp Ala Gln Thr 
        355                 360                 365         


<210>  8
<211>  718
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  8

Leu His Gln Gln Gln Pro Leu His Pro Glu Trp Ala Ala Leu Ala Lys 
1               5                   10                  15      


Lys Gln Leu Lys Gly Lys Asn Pro Glu Asp Leu Ile Trp His Thr Pro 
            20                  25                  30          


Glu Gly Ile Ser Ile Lys Pro Leu Tyr Ser Lys Arg Asp Thr Met Asp 
        35                  40                  45              


Leu Pro Glu Glu Leu Pro Gly Val Lys Pro Phe Thr Arg Gly Pro Tyr 
    50                  55                  60                  


Pro Thr Met Tyr Thr Phe Arg Pro Trp Thr Ile Arg Gln Tyr Ala Gly 
65                  70                  75                  80  


Phe Ser Thr Val Glu Glu Ser Asn Lys Phe Tyr Lys Asp Asn Ile Lys 
                85                  90                  95      


Ala Gly Gln Gln Gly Leu Ser Val Ala Phe Asp Leu Ala Thr His Arg 
            100                 105                 110         


Gly Tyr Asp Ser Asp Asn Pro Arg Val Arg Gly Asp Val Gly Met Ala 
        115                 120                 125             


Gly Val Ala Ile Asp Thr Val Glu Asp Thr Lys Ile Leu Phe Asp Gly 
    130                 135                 140                 


Ile Pro Leu Glu Lys Met Ser Val Ser Met Thr Met Asn Gly Ala Val 
145                 150                 155                 160 


Ile Pro Val Leu Ala Asn Phe Ile Val Thr Gly Glu Glu Gln Gly Val 
                165                 170                 175     


Pro Lys Glu Lys Leu Thr Gly Thr Ile Gln Asn Asp Ile Leu Lys Glu 
            180                 185                 190         


Phe Met Val Arg Asn Thr Tyr Ile Phe Pro Pro Glu Pro Ser Met Lys 
        195                 200                 205             


Ile Ile Ala Asp Ile Phe Glu Tyr Thr Ala Lys His Met Pro Lys Phe 
    210                 215                 220                 


Asn Ser Ile Ser Ile Ser Gly Tyr His Met Gln Glu Ala Gly Ala Asp 
225                 230                 235                 240 


Ala Ile Leu Glu Leu Ala Tyr Thr Leu Ala Asp Gly Leu Glu Tyr Ser 
                245                 250                 255     


Arg Thr Gly Leu Gln Ala Gly Leu Thr Ile Asp Glu Phe Ala Pro Arg 
            260                 265                 270         


Leu Ser Phe Phe Trp Gly Ile Gly Met Asn Phe Tyr Met Glu Ile Ala 
        275                 280                 285             


Lys Met Arg Ala Gly Arg Arg Leu Trp Ala His Leu Ile Glu Lys Met 
    290                 295                 300                 


Phe Gln Pro Lys Asn Ser Lys Ser Leu Leu Leu Arg Ala His Cys Gln 
305                 310                 315                 320 


Thr Ser Gly Trp Ser Leu Thr Glu Gln Asp Pro Tyr Asn Asn Ile Val 
                325                 330                 335     


Arg Thr Ala Ile Glu Ala Met Ala Ala Val Phe Gly Gly Thr Gln Ser 
            340                 345                 350         


Leu His Thr Asn Ser Phe Asp Glu Ala Leu Gly Leu Pro Thr Val Lys 
        355                 360                 365             


Ser Ala Arg Ile Ala Arg Asn Thr Gln Ile Ile Ile Gln Glu Glu Ser 
    370                 375                 380                 


Gly Ile Pro Lys Val Ala Asp Pro Trp Gly Gly Ser Tyr Met Met Glu 
385                 390                 395                 400 


Cys Leu Thr Asn Asp Val Tyr Asp Ala Ala Leu Lys Leu Ile Asn Glu 
                405                 410                 415     


Ile Glu Glu Met Gly Gly Met Ala Lys Ala Val Ala Glu Gly Ile Pro 
            420                 425                 430         


Lys Leu Arg Ile Glu Glu Cys Ala Ala Arg Arg Gln Ala Arg Ile Asp 
        435                 440                 445             


Ser Gly Ser Glu Val Ile Val Gly Val Asn Lys Tyr Gln Leu Glu Lys 
    450                 455                 460                 


Glu Asp Ala Val Glu Val Leu Ala Ile Asp Asn Thr Ser Val Arg Asn 
465                 470                 475                 480 


Arg Gln Ile Glu Lys Leu Lys Lys Ile Lys Ser Ser Arg Asp Gln Ala 
                485                 490                 495     


Leu Ala Glu Arg Cys Leu Ala Ala Leu Thr Glu Cys Ala Ala Ser Gly 
            500                 505                 510         


Asp Gly Asn Ile Leu Ala Leu Ala Val Asp Ala Ser Arg Ala Arg Cys 
        515                 520                 525             


Thr Val Gly Glu Ile Thr Asp Ala Leu Lys Lys Val Phe Gly Glu His 
    530                 535                 540                 


Lys Ala Asn Asp Arg Met Val Ser Gly Ala Tyr Arg Gln Glu Phe Gly 
545                 550                 555                 560 


Glu Ser Lys Glu Ile Thr Ser Ala Ile Lys Arg Val His Lys Phe Met 
                565                 570                 575     


Glu Arg Glu Gly Arg Arg Pro Arg Leu Leu Val Ala Lys Met Gly Gln 
            580                 585                 590         


Asp Gly His Asp Arg Gly Ala Lys Val Ile Ala Thr Gly Phe Ala Asp 
        595                 600                 605             


Leu Gly Phe Asp Val Asp Ile Gly Pro Leu Phe Gln Thr Pro Arg Glu 
    610                 615                 620                 


Val Ala Gln Gln Ala Val Asp Ala Asp Val His Ala Val Gly Ile Ser 
625                 630                 635                 640 


Thr Leu Ala Ala Gly His Lys Thr Leu Val Pro Glu Leu Ile Lys Glu 
                645                 650                 655     


Leu Asn Ser Leu Gly Arg Pro Asp Ile Leu Val Met Cys Gly Gly Val 
            660                 665                 670         


Ile Pro Pro Gln Asp Tyr Glu Phe Leu Phe Glu Val Gly Val Ser Asn 
        675                 680                 685             


Val Phe Gly Pro Gly Thr Arg Ile Pro Lys Ala Ala Val Gln Val Leu 
    690                 695                 700                 


Asp Asp Ile Glu Lys Cys Leu Glu Lys Lys Gln Gln Ser Val 
705                 710                 715             


<210>  9
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  9

Met Gly Ser Ser 
1               


<210>  10
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  10

Ser Ser Gly Leu Val Pro Arg Gly Ser His Met 
1               5                   10      


<210>  11
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  11

Gly Ser Asp Pro Asn Ser Ser Ser 
1               5               


<210>  12
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  12

Gly Ser Asp Pro 
1               


<210>  13
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  13

Gly Ser Asp Pro Met 
1               5   


<210>  14
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  14

Asn Gly Ile Glu 
1               


<210>  15
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  15

Glu Asn Leu Tyr Phe Gln Ser 
1               5           


<210>  16
<211>  781
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  16

Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser His Met Arg Lys Lys Arg Arg Gln Arg Arg Arg Gly Ser 
            20                  25                  30          


Asp Pro Ala Leu Leu Thr Ala Ala Ala Arg Leu Leu Gly Thr Lys Asn 
        35                  40                  45              


Ala Ser Cys Leu Val Leu Ala Ala Arg His Ala Ser Gly Ser Ser Leu 
    50                  55                  60                  


His Gln Gln Gln Pro Leu His Pro Glu Trp Ala Ala Leu Ala Lys Lys 
65                  70                  75                  80  


Gln Leu Lys Gly Lys Asn Pro Glu Asp Leu Ile Trp His Thr Pro Glu 
                85                  90                  95      


Gly Ile Ser Ile Lys Pro Leu Tyr Ser Lys Arg Asp Thr Met Asp Leu 
            100                 105                 110         


Pro Glu Glu Leu Pro Gly Val Lys Pro Phe Thr Arg Gly Pro Tyr Pro 
        115                 120                 125             


Thr Met Tyr Thr Phe Arg Pro Trp Thr Ile Arg Gln Tyr Ala Gly Phe 
    130                 135                 140                 


Ser Thr Val Glu Glu Ser Asn Lys Phe Tyr Lys Asp Asn Ile Lys Ala 
145                 150                 155                 160 


Gly Gln Gln Gly Leu Ser Val Ala Phe Asp Leu Ala Thr His Arg Gly 
                165                 170                 175     


Tyr Asp Ser Asp Asn Pro Arg Val Arg Gly Asp Val Gly Met Ala Gly 
            180                 185                 190         


Val Ala Ile Asp Thr Val Glu Asp Thr Lys Ile Leu Phe Asp Gly Ile 
        195                 200                 205             


Pro Leu Glu Lys Met Ser Val Ser Met Thr Met Asn Gly Ala Val Ile 
    210                 215                 220                 


Pro Val Leu Ala Asn Phe Ile Val Thr Gly Glu Glu Gln Gly Val Pro 
225                 230                 235                 240 


Lys Glu Lys Leu Thr Gly Thr Ile Gln Asn Asp Ile Leu Lys Glu Phe 
                245                 250                 255     


Met Val Arg Asn Thr Tyr Ile Phe Pro Pro Glu Pro Ser Met Lys Ile 
            260                 265                 270         


Ile Ala Asp Ile Phe Glu Tyr Thr Ala Lys His Met Pro Lys Phe Asn 
        275                 280                 285             


Ser Ile Ser Ile Ser Gly Tyr His Met Gln Glu Ala Gly Ala Asp Ala 
    290                 295                 300                 


Ile Leu Glu Leu Ala Tyr Thr Leu Ala Asp Gly Leu Glu Tyr Ser Arg 
305                 310                 315                 320 


Thr Gly Leu Gln Ala Gly Leu Thr Ile Asp Glu Phe Ala Pro Arg Leu 
                325                 330                 335     


Ser Phe Phe Trp Gly Ile Gly Met Asn Phe Tyr Met Glu Ile Ala Lys 
            340                 345                 350         


Met Arg Ala Gly Arg Arg Leu Trp Ala His Leu Ile Glu Lys Met Phe 
        355                 360                 365             


Gln Pro Lys Asn Ser Lys Ser Leu Leu Leu Arg Ala His Cys Gln Thr 
    370                 375                 380                 


Ser Gly Trp Ser Leu Thr Glu Gln Asp Pro Tyr Asn Asn Ile Val Arg 
385                 390                 395                 400 


Thr Ala Ile Glu Ala Met Ala Ala Val Phe Gly Gly Thr Gln Ser Leu 
                405                 410                 415     


His Thr Asn Ser Phe Asp Glu Ala Leu Gly Leu Pro Thr Val Lys Ser 
            420                 425                 430         


Ala Arg Ile Ala Arg Asn Thr Gln Ile Ile Ile Gln Glu Glu Ser Gly 
        435                 440                 445             


Ile Pro Lys Val Ala Asp Pro Trp Gly Gly Ser Tyr Met Met Glu Cys 
    450                 455                 460                 


Leu Thr Asn Asp Val Tyr Asp Ala Ala Leu Lys Leu Ile Asn Glu Ile 
465                 470                 475                 480 


Glu Glu Met Gly Gly Met Ala Lys Ala Val Ala Glu Gly Ile Pro Lys 
                485                 490                 495     


Leu Arg Ile Glu Glu Cys Ala Ala Arg Arg Gln Ala Arg Ile Asp Ser 
            500                 505                 510         


Gly Ser Glu Val Ile Val Gly Val Asn Lys Tyr Gln Leu Glu Lys Glu 
        515                 520                 525             


Asp Ala Val Glu Val Leu Ala Ile Asp Asn Thr Ser Val Arg Asn Arg 
    530                 535                 540                 


Gln Ile Glu Lys Leu Lys Lys Ile Lys Ser Ser Arg Asp Gln Ala Leu 
545                 550                 555                 560 


Ala Glu Arg Cys Leu Ala Ala Leu Thr Glu Cys Ala Ala Ser Gly Asp 
                565                 570                 575     


Gly Asn Ile Leu Ala Leu Ala Val Asp Ala Ser Arg Ala Arg Cys Thr 
            580                 585                 590         


Val Gly Glu Ile Thr Asp Ala Leu Lys Lys Val Phe Gly Glu His Lys 
        595                 600                 605             


Ala Asn Asp Arg Met Val Ser Gly Ala Tyr Arg Gln Glu Phe Gly Glu 
    610                 615                 620                 


Ser Lys Glu Ile Thr Ser Ala Ile Lys Arg Val His Lys Phe Met Glu 
625                 630                 635                 640 


Arg Glu Gly Arg Arg Pro Arg Leu Leu Val Ala Lys Met Gly Gln Asp 
                645                 650                 655     


Gly His Asp Arg Gly Ala Lys Val Ile Ala Thr Gly Phe Ala Asp Leu 
            660                 665                 670         


Gly Phe Asp Val Asp Ile Gly Pro Leu Phe Gln Thr Pro Arg Glu Val 
        675                 680                 685             


Ala Gln Gln Ala Val Asp Ala Asp Val His Ala Val Gly Ile Ser Thr 
    690                 695                 700                 


Leu Ala Ala Gly His Lys Thr Leu Val Pro Glu Leu Ile Lys Glu Leu 
705                 710                 715                 720 


Asn Ser Leu Gly Arg Pro Asp Ile Leu Val Met Cys Gly Gly Val Ile 
                725                 730                 735     


Pro Pro Gln Asp Tyr Glu Phe Leu Phe Glu Val Gly Val Ser Asn Val 
            740                 745                 750         


Phe Gly Pro Gly Thr Arg Ile Pro Lys Ala Ala Val Gln Val Leu Asp 
        755                 760                 765             


Asp Ile Glu Lys Cys Leu Glu Lys Lys Gln Gln Ser Val 
    770                 775                 780     


<210>  17
<211>  778
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  17

Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser His Met Arg Lys Lys Arg Arg Gln Arg Arg Arg Gly Ser 
            20                  25                  30          


Asp Pro Ala Leu Leu Thr Ala Ala Ala Arg Leu Leu Gly Thr Lys Asn 
        35                  40                  45              


Ala Ser Cys Leu Val Leu Ala Ala Arg His Ala Ser Leu His Gln Gln 
    50                  55                  60                  


Gln Pro Leu His Pro Glu Trp Ala Ala Leu Ala Lys Lys Gln Leu Lys 
65                  70                  75                  80  


Gly Lys Asn Pro Glu Asp Leu Ile Trp His Thr Pro Glu Gly Ile Ser 
                85                  90                  95      


Ile Lys Pro Leu Tyr Ser Lys Arg Asp Thr Met Asp Leu Pro Glu Glu 
            100                 105                 110         


Leu Pro Gly Val Lys Pro Phe Thr Arg Gly Pro Tyr Pro Thr Met Tyr 
        115                 120                 125             


Thr Phe Arg Pro Trp Thr Ile Arg Gln Tyr Ala Gly Phe Ser Thr Val 
    130                 135                 140                 


Glu Glu Ser Asn Lys Phe Tyr Lys Asp Asn Ile Lys Ala Gly Gln Gln 
145                 150                 155                 160 


Gly Leu Ser Val Ala Phe Asp Leu Ala Thr His Arg Gly Tyr Asp Ser 
                165                 170                 175     


Asp Asn Pro Arg Val Arg Gly Asp Val Gly Met Ala Gly Val Ala Ile 
            180                 185                 190         


Asp Thr Val Glu Asp Thr Lys Ile Leu Phe Asp Gly Ile Pro Leu Glu 
        195                 200                 205             


Lys Met Ser Val Ser Met Thr Met Asn Gly Ala Val Ile Pro Val Leu 
    210                 215                 220                 


Ala Asn Phe Ile Val Thr Gly Glu Glu Gln Gly Val Pro Lys Glu Lys 
225                 230                 235                 240 


Leu Thr Gly Thr Ile Gln Asn Asp Ile Leu Lys Glu Phe Met Val Arg 
                245                 250                 255     


Asn Thr Tyr Ile Phe Pro Pro Glu Pro Ser Met Lys Ile Ile Ala Asp 
            260                 265                 270         


Ile Phe Glu Tyr Thr Ala Lys His Met Pro Lys Phe Asn Ser Ile Ser 
        275                 280                 285             


Ile Ser Gly Tyr His Met Gln Glu Ala Gly Ala Asp Ala Ile Leu Glu 
    290                 295                 300                 


Leu Ala Tyr Thr Leu Ala Asp Gly Leu Glu Tyr Ser Arg Thr Gly Leu 
305                 310                 315                 320 


Gln Ala Gly Leu Thr Ile Asp Glu Phe Ala Pro Arg Leu Ser Phe Phe 
                325                 330                 335     


Trp Gly Ile Gly Met Asn Phe Tyr Met Glu Ile Ala Lys Met Arg Ala 
            340                 345                 350         


Gly Arg Arg Leu Trp Ala His Leu Ile Glu Lys Met Phe Gln Pro Lys 
        355                 360                 365             


Asn Ser Lys Ser Leu Leu Leu Arg Ala His Cys Gln Thr Ser Gly Trp 
    370                 375                 380                 


Ser Leu Thr Glu Gln Asp Pro Tyr Asn Asn Ile Val Arg Thr Ala Ile 
385                 390                 395                 400 


Glu Ala Met Ala Ala Val Phe Gly Gly Thr Gln Ser Leu His Thr Asn 
                405                 410                 415     


Ser Phe Asp Glu Ala Leu Gly Leu Pro Thr Val Lys Ser Ala Arg Ile 
            420                 425                 430         


Ala Arg Asn Thr Gln Ile Ile Ile Gln Glu Glu Ser Gly Ile Pro Lys 
        435                 440                 445             


Val Ala Asp Pro Trp Gly Gly Ser Tyr Met Met Glu Cys Leu Thr Asn 
    450                 455                 460                 


Asp Val Tyr Asp Ala Ala Leu Lys Leu Ile Asn Glu Ile Glu Glu Met 
465                 470                 475                 480 


Gly Gly Met Ala Lys Ala Val Ala Glu Gly Ile Pro Lys Leu Arg Ile 
                485                 490                 495     


Glu Glu Cys Ala Ala Arg Arg Gln Ala Arg Ile Asp Ser Gly Ser Glu 
            500                 505                 510         


Val Ile Val Gly Val Asn Lys Tyr Gln Leu Glu Lys Glu Asp Ala Val 
        515                 520                 525             


Glu Val Leu Ala Ile Asp Asn Thr Ser Val Arg Asn Arg Gln Ile Glu 
    530                 535                 540                 


Lys Leu Lys Lys Ile Lys Ser Ser Arg Asp Gln Ala Leu Ala Glu Arg 
545                 550                 555                 560 


Cys Leu Ala Ala Leu Thr Glu Cys Ala Ala Ser Gly Asp Gly Asn Ile 
                565                 570                 575     


Leu Ala Leu Ala Val Asp Ala Ser Arg Ala Arg Cys Thr Val Gly Glu 
            580                 585                 590         


Ile Thr Asp Ala Leu Lys Lys Val Phe Gly Glu His Lys Ala Asn Asp 
        595                 600                 605             


Arg Met Val Ser Gly Ala Tyr Arg Gln Glu Phe Gly Glu Ser Lys Glu 
    610                 615                 620                 


Ile Thr Ser Ala Ile Lys Arg Val His Lys Phe Met Glu Arg Glu Gly 
625                 630                 635                 640 


Arg Arg Pro Arg Leu Leu Val Ala Lys Met Gly Gln Asp Gly His Asp 
                645                 650                 655     


Arg Gly Ala Lys Val Ile Ala Thr Gly Phe Ala Asp Leu Gly Phe Asp 
            660                 665                 670         


Val Asp Ile Gly Pro Leu Phe Gln Thr Pro Arg Glu Val Ala Gln Gln 
        675                 680                 685             


Ala Val Asp Ala Asp Val His Ala Val Gly Ile Ser Thr Leu Ala Ala 
    690                 695                 700                 


Gly His Lys Thr Leu Val Pro Glu Leu Ile Lys Glu Leu Asn Ser Leu 
705                 710                 715                 720 


Gly Arg Pro Asp Ile Leu Val Met Cys Gly Gly Val Ile Pro Pro Gln 
                725                 730                 735     


Asp Tyr Glu Phe Leu Phe Glu Val Gly Val Ser Asn Val Phe Gly Pro 
            740                 745                 750         


Gly Thr Arg Ile Pro Lys Ala Ala Val Gln Val Leu Asp Asp Ile Glu 
        755                 760                 765             


Lys Cys Leu Glu Lys Lys Gln Gln Ser Val 
    770                 775             


<210>  18
<211>  787
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  18

Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser His Met Arg Lys Lys Arg Arg Gln Arg Arg Arg Gly Ser 
            20                  25                  30          


Asp Pro Asn Ser Ser Ser Leu Arg Ala Lys Asn Gln Leu Phe Leu Leu 
        35                  40                  45              


Ser Pro His Tyr Leu Arg Gln Val Lys Glu Ser Ser Gly Ser Arg Leu 
    50                  55                  60                  


Ile Gln Gln Arg Leu Leu His Gln Gln Gln Pro Leu His Pro Glu Trp 
65                  70                  75                  80  


Ala Ala Leu Ala Lys Lys Gln Leu Lys Gly Lys Asn Pro Glu Asp Leu 
                85                  90                  95      


Ile Trp His Thr Pro Glu Gly Ile Ser Ile Lys Pro Leu Tyr Ser Lys 
            100                 105                 110         


Arg Asp Thr Met Asp Leu Pro Glu Glu Leu Pro Gly Val Lys Pro Phe 
        115                 120                 125             


Thr Arg Gly Pro Tyr Pro Thr Met Tyr Thr Phe Arg Pro Trp Thr Ile 
    130                 135                 140                 


Arg Gln Tyr Ala Gly Phe Ser Thr Val Glu Glu Ser Asn Lys Phe Tyr 
145                 150                 155                 160 


Lys Asp Asn Ile Lys Ala Gly Gln Gln Gly Leu Ser Val Ala Phe Asp 
                165                 170                 175     


Leu Ala Thr His Arg Gly Tyr Asp Ser Asp Asn Pro Arg Val Arg Gly 
            180                 185                 190         


Asp Val Gly Met Ala Gly Val Ala Ile Asp Thr Val Glu Asp Thr Lys 
        195                 200                 205             


Ile Leu Phe Asp Gly Ile Pro Leu Glu Lys Met Ser Val Ser Met Thr 
    210                 215                 220                 


Met Asn Gly Ala Val Ile Pro Val Leu Ala Asn Phe Ile Val Thr Gly 
225                 230                 235                 240 


Glu Glu Gln Gly Val Pro Lys Glu Lys Leu Thr Gly Thr Ile Gln Asn 
                245                 250                 255     


Asp Ile Leu Lys Glu Phe Met Val Arg Asn Thr Tyr Ile Phe Pro Pro 
            260                 265                 270         


Glu Pro Ser Met Lys Ile Ile Ala Asp Ile Phe Glu Tyr Thr Ala Lys 
        275                 280                 285             


His Met Pro Lys Phe Asn Ser Ile Ser Ile Ser Gly Tyr His Met Gln 
    290                 295                 300                 


Glu Ala Gly Ala Asp Ala Ile Leu Glu Leu Ala Tyr Thr Leu Ala Asp 
305                 310                 315                 320 


Gly Leu Glu Tyr Ser Arg Thr Gly Leu Gln Ala Gly Leu Thr Ile Asp 
                325                 330                 335     


Glu Phe Ala Pro Arg Leu Ser Phe Phe Trp Gly Ile Gly Met Asn Phe 
            340                 345                 350         


Tyr Met Glu Ile Ala Lys Met Arg Ala Gly Arg Arg Leu Trp Ala His 
        355                 360                 365             


Leu Ile Glu Lys Met Phe Gln Pro Lys Asn Ser Lys Ser Leu Leu Leu 
    370                 375                 380                 


Arg Ala His Cys Gln Thr Ser Gly Trp Ser Leu Thr Glu Gln Asp Pro 
385                 390                 395                 400 


Tyr Asn Asn Ile Val Arg Thr Ala Ile Glu Ala Met Ala Ala Val Phe 
                405                 410                 415     


Gly Gly Thr Gln Ser Leu His Thr Asn Ser Phe Asp Glu Ala Leu Gly 
            420                 425                 430         


Leu Pro Thr Val Lys Ser Ala Arg Ile Ala Arg Asn Thr Gln Ile Ile 
        435                 440                 445             


Ile Gln Glu Glu Ser Gly Ile Pro Lys Val Ala Asp Pro Trp Gly Gly 
    450                 455                 460                 


Ser Tyr Met Met Glu Cys Leu Thr Asn Asp Val Tyr Asp Ala Ala Leu 
465                 470                 475                 480 


Lys Leu Ile Asn Glu Ile Glu Glu Met Gly Gly Met Ala Lys Ala Val 
                485                 490                 495     


Ala Glu Gly Ile Pro Lys Leu Arg Ile Glu Glu Cys Ala Ala Arg Arg 
            500                 505                 510         


Gln Ala Arg Ile Asp Ser Gly Ser Glu Val Ile Val Gly Val Asn Lys 
        515                 520                 525             


Tyr Gln Leu Glu Lys Glu Asp Ala Val Glu Val Leu Ala Ile Asp Asn 
    530                 535                 540                 


Thr Ser Val Arg Asn Arg Gln Ile Glu Lys Leu Lys Lys Ile Lys Ser 
545                 550                 555                 560 


Ser Arg Asp Gln Ala Leu Ala Glu Arg Cys Leu Ala Ala Leu Thr Glu 
                565                 570                 575     


Cys Ala Ala Ser Gly Asp Gly Asn Ile Leu Ala Leu Ala Val Asp Ala 
            580                 585                 590         


Ser Arg Ala Arg Cys Thr Val Gly Glu Ile Thr Asp Ala Leu Lys Lys 
        595                 600                 605             


Val Phe Gly Glu His Lys Ala Asn Asp Arg Met Val Ser Gly Ala Tyr 
    610                 615                 620                 


Arg Gln Glu Phe Gly Glu Ser Lys Glu Ile Thr Ser Ala Ile Lys Arg 
625                 630                 635                 640 


Val His Lys Phe Met Glu Arg Glu Gly Arg Arg Pro Arg Leu Leu Val 
                645                 650                 655     


Ala Lys Met Gly Gln Asp Gly His Asp Arg Gly Ala Lys Val Ile Ala 
            660                 665                 670         


Thr Gly Phe Ala Asp Leu Gly Phe Asp Val Asp Ile Gly Pro Leu Phe 
        675                 680                 685             


Gln Thr Pro Arg Glu Val Ala Gln Gln Ala Val Asp Ala Asp Val His 
    690                 695                 700                 


Ala Val Gly Ile Ser Thr Leu Ala Ala Gly His Lys Thr Leu Val Pro 
705                 710                 715                 720 


Glu Leu Ile Lys Glu Leu Asn Ser Leu Gly Arg Pro Asp Ile Leu Val 
                725                 730                 735     


Met Cys Gly Gly Val Ile Pro Pro Gln Asp Tyr Glu Phe Leu Phe Glu 
            740                 745                 750         


Val Gly Val Ser Asn Val Phe Gly Pro Gly Thr Arg Ile Pro Lys Ala 
        755                 760                 765             


Ala Val Gln Val Leu Asp Asp Ile Glu Lys Cys Leu Glu Lys Lys Gln 
    770                 775                 780                 


Gln Ser Val 
785         


<210>  19
<211>  784
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  19

Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser His Met Arg Lys Lys Arg Arg Gln Arg Arg Arg Gly Ser 
            20                  25                  30          


Asp Pro Met Leu Arg Ala Lys Asn Gln Leu Phe Leu Leu Ser Pro His 
        35                  40                  45              


Tyr Leu Arg Gln Val Lys Glu Ser Ser Gly Ser Arg Leu Ile Gln Gln 
    50                  55                  60                  


Arg Leu Leu His Gln Gln Gln Pro Leu His Pro Glu Trp Ala Ala Leu 
65                  70                  75                  80  


Ala Lys Lys Gln Leu Lys Gly Lys Asn Pro Glu Asp Leu Ile Trp His 
                85                  90                  95      


Thr Pro Glu Gly Ile Ser Ile Lys Pro Leu Tyr Ser Lys Arg Asp Thr 
            100                 105                 110         


Met Asp Leu Pro Glu Glu Leu Pro Gly Val Lys Pro Phe Thr Arg Gly 
        115                 120                 125             


Pro Tyr Pro Thr Met Tyr Thr Phe Arg Pro Trp Thr Ile Arg Gln Tyr 
    130                 135                 140                 


Ala Gly Phe Ser Thr Val Glu Glu Ser Asn Lys Phe Tyr Lys Asp Asn 
145                 150                 155                 160 


Ile Lys Ala Gly Gln Gln Gly Leu Ser Val Ala Phe Asp Leu Ala Thr 
                165                 170                 175     


His Arg Gly Tyr Asp Ser Asp Asn Pro Arg Val Arg Gly Asp Val Gly 
            180                 185                 190         


Met Ala Gly Val Ala Ile Asp Thr Val Glu Asp Thr Lys Ile Leu Phe 
        195                 200                 205             


Asp Gly Ile Pro Leu Glu Lys Met Ser Val Ser Met Thr Met Asn Gly 
    210                 215                 220                 


Ala Val Ile Pro Val Leu Ala Asn Phe Ile Val Thr Gly Glu Glu Gln 
225                 230                 235                 240 


Gly Val Pro Lys Glu Lys Leu Thr Gly Thr Ile Gln Asn Asp Ile Leu 
                245                 250                 255     


Lys Glu Phe Met Val Arg Asn Thr Tyr Ile Phe Pro Pro Glu Pro Ser 
            260                 265                 270         


Met Lys Ile Ile Ala Asp Ile Phe Glu Tyr Thr Ala Lys His Met Pro 
        275                 280                 285             


Lys Phe Asn Ser Ile Ser Ile Ser Gly Tyr His Met Gln Glu Ala Gly 
    290                 295                 300                 


Ala Asp Ala Ile Leu Glu Leu Ala Tyr Thr Leu Ala Asp Gly Leu Glu 
305                 310                 315                 320 


Tyr Ser Arg Thr Gly Leu Gln Ala Gly Leu Thr Ile Asp Glu Phe Ala 
                325                 330                 335     


Pro Arg Leu Ser Phe Phe Trp Gly Ile Gly Met Asn Phe Tyr Met Glu 
            340                 345                 350         


Ile Ala Lys Met Arg Ala Gly Arg Arg Leu Trp Ala His Leu Ile Glu 
        355                 360                 365             


Lys Met Phe Gln Pro Lys Asn Ser Lys Ser Leu Leu Leu Arg Ala His 
    370                 375                 380                 


Cys Gln Thr Ser Gly Trp Ser Leu Thr Glu Gln Asp Pro Tyr Asn Asn 
385                 390                 395                 400 


Ile Val Arg Thr Ala Ile Glu Ala Met Ala Ala Val Phe Gly Gly Thr 
                405                 410                 415     


Gln Ser Leu His Thr Asn Ser Phe Asp Glu Ala Leu Gly Leu Pro Thr 
            420                 425                 430         


Val Lys Ser Ala Arg Ile Ala Arg Asn Thr Gln Ile Ile Ile Gln Glu 
        435                 440                 445             


Glu Ser Gly Ile Pro Lys Val Ala Asp Pro Trp Gly Gly Ser Tyr Met 
    450                 455                 460                 


Met Glu Cys Leu Thr Asn Asp Val Tyr Asp Ala Ala Leu Lys Leu Ile 
465                 470                 475                 480 


Asn Glu Ile Glu Glu Met Gly Gly Met Ala Lys Ala Val Ala Glu Gly 
                485                 490                 495     


Ile Pro Lys Leu Arg Ile Glu Glu Cys Ala Ala Arg Arg Gln Ala Arg 
            500                 505                 510         


Ile Asp Ser Gly Ser Glu Val Ile Val Gly Val Asn Lys Tyr Gln Leu 
        515                 520                 525             


Glu Lys Glu Asp Ala Val Glu Val Leu Ala Ile Asp Asn Thr Ser Val 
    530                 535                 540                 


Arg Asn Arg Gln Ile Glu Lys Leu Lys Lys Ile Lys Ser Ser Arg Asp 
545                 550                 555                 560 


Gln Ala Leu Ala Glu Arg Cys Leu Ala Ala Leu Thr Glu Cys Ala Ala 
                565                 570                 575     


Ser Gly Asp Gly Asn Ile Leu Ala Leu Ala Val Asp Ala Ser Arg Ala 
            580                 585                 590         


Arg Cys Thr Val Gly Glu Ile Thr Asp Ala Leu Lys Lys Val Phe Gly 
        595                 600                 605             


Glu His Lys Ala Asn Asp Arg Met Val Ser Gly Ala Tyr Arg Gln Glu 
    610                 615                 620                 


Phe Gly Glu Ser Lys Glu Ile Thr Ser Ala Ile Lys Arg Val His Lys 
625                 630                 635                 640 


Phe Met Glu Arg Glu Gly Arg Arg Pro Arg Leu Leu Val Ala Lys Met 
                645                 650                 655     


Gly Gln Asp Gly His Asp Arg Gly Ala Lys Val Ile Ala Thr Gly Phe 
            660                 665                 670         


Ala Asp Leu Gly Phe Asp Val Asp Ile Gly Pro Leu Phe Gln Thr Pro 
        675                 680                 685             


Arg Glu Val Ala Gln Gln Ala Val Asp Ala Asp Val His Ala Val Gly 
    690                 695                 700                 


Ile Ser Thr Leu Ala Ala Gly His Lys Thr Leu Val Pro Glu Leu Ile 
705                 710                 715                 720 


Lys Glu Leu Asn Ser Leu Gly Arg Pro Asp Ile Leu Val Met Cys Gly 
                725                 730                 735     


Gly Val Ile Pro Pro Gln Asp Tyr Glu Phe Leu Phe Glu Val Gly Val 
            740                 745                 750         


Ser Asn Val Phe Gly Pro Gly Thr Arg Ile Pro Lys Ala Ala Val Gln 
        755                 760                 765             


Val Leu Asp Asp Ile Glu Lys Cys Leu Glu Lys Lys Gln Gln Ser Val 
    770                 775                 780                 


<210>  20
<211>  790
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  20

Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser His Met Arg Lys Lys Arg Arg Gln Arg Arg Arg Gly Ser 
            20                  25                  30          


Asp Pro Gln Ser Trp Ser Arg Val Tyr Cys Ser Leu Ala Lys Arg Gly 
        35                  40                  45              


His Phe Asn Arg Ile Ser His Gly Leu Gln Gly Leu Ser Ala Val Pro 
    50                  55                  60                  


Leu Arg Thr Tyr Ala Gly Ser Ser Leu His Gln Gln Gln Pro Leu His 
65                  70                  75                  80  


Pro Glu Trp Ala Ala Leu Ala Lys Lys Gln Leu Lys Gly Lys Asn Pro 
                85                  90                  95      


Glu Asp Leu Ile Trp His Thr Pro Glu Gly Ile Ser Ile Lys Pro Leu 
            100                 105                 110         


Tyr Ser Lys Arg Asp Thr Met Asp Leu Pro Glu Glu Leu Pro Gly Val 
        115                 120                 125             


Lys Pro Phe Thr Arg Gly Pro Tyr Pro Thr Met Tyr Thr Phe Arg Pro 
    130                 135                 140                 


Trp Thr Ile Arg Gln Tyr Ala Gly Phe Ser Thr Val Glu Glu Ser Asn 
145                 150                 155                 160 


Lys Phe Tyr Lys Asp Asn Ile Lys Ala Gly Gln Gln Gly Leu Ser Val 
                165                 170                 175     


Ala Phe Asp Leu Ala Thr His Arg Gly Tyr Asp Ser Asp Asn Pro Arg 
            180                 185                 190         


Val Arg Gly Asp Val Gly Met Ala Gly Val Ala Ile Asp Thr Val Glu 
        195                 200                 205             


Asp Thr Lys Ile Leu Phe Asp Gly Ile Pro Leu Glu Lys Met Ser Val 
    210                 215                 220                 


Ser Met Thr Met Asn Gly Ala Val Ile Pro Val Leu Ala Asn Phe Ile 
225                 230                 235                 240 


Val Thr Gly Glu Glu Gln Gly Val Pro Lys Glu Lys Leu Thr Gly Thr 
                245                 250                 255     


Ile Gln Asn Asp Ile Leu Lys Glu Phe Met Val Arg Asn Thr Tyr Ile 
            260                 265                 270         


Phe Pro Pro Glu Pro Ser Met Lys Ile Ile Ala Asp Ile Phe Glu Tyr 
        275                 280                 285             


Thr Ala Lys His Met Pro Lys Phe Asn Ser Ile Ser Ile Ser Gly Tyr 
    290                 295                 300                 


His Met Gln Glu Ala Gly Ala Asp Ala Ile Leu Glu Leu Ala Tyr Thr 
305                 310                 315                 320 


Leu Ala Asp Gly Leu Glu Tyr Ser Arg Thr Gly Leu Gln Ala Gly Leu 
                325                 330                 335     


Thr Ile Asp Glu Phe Ala Pro Arg Leu Ser Phe Phe Trp Gly Ile Gly 
            340                 345                 350         


Met Asn Phe Tyr Met Glu Ile Ala Lys Met Arg Ala Gly Arg Arg Leu 
        355                 360                 365             


Trp Ala His Leu Ile Glu Lys Met Phe Gln Pro Lys Asn Ser Lys Ser 
    370                 375                 380                 


Leu Leu Leu Arg Ala His Cys Gln Thr Ser Gly Trp Ser Leu Thr Glu 
385                 390                 395                 400 


Gln Asp Pro Tyr Asn Asn Ile Val Arg Thr Ala Ile Glu Ala Met Ala 
                405                 410                 415     


Ala Val Phe Gly Gly Thr Gln Ser Leu His Thr Asn Ser Phe Asp Glu 
            420                 425                 430         


Ala Leu Gly Leu Pro Thr Val Lys Ser Ala Arg Ile Ala Arg Asn Thr 
        435                 440                 445             


Gln Ile Ile Ile Gln Glu Glu Ser Gly Ile Pro Lys Val Ala Asp Pro 
    450                 455                 460                 


Trp Gly Gly Ser Tyr Met Met Glu Cys Leu Thr Asn Asp Val Tyr Asp 
465                 470                 475                 480 


Ala Ala Leu Lys Leu Ile Asn Glu Ile Glu Glu Met Gly Gly Met Ala 
                485                 490                 495     


Lys Ala Val Ala Glu Gly Ile Pro Lys Leu Arg Ile Glu Glu Cys Ala 
            500                 505                 510         


Ala Arg Arg Gln Ala Arg Ile Asp Ser Gly Ser Glu Val Ile Val Gly 
        515                 520                 525             


Val Asn Lys Tyr Gln Leu Glu Lys Glu Asp Ala Val Glu Val Leu Ala 
    530                 535                 540                 


Ile Asp Asn Thr Ser Val Arg Asn Arg Gln Ile Glu Lys Leu Lys Lys 
545                 550                 555                 560 


Ile Lys Ser Ser Arg Asp Gln Ala Leu Ala Glu Arg Cys Leu Ala Ala 
                565                 570                 575     


Leu Thr Glu Cys Ala Ala Ser Gly Asp Gly Asn Ile Leu Ala Leu Ala 
            580                 585                 590         


Val Asp Ala Ser Arg Ala Arg Cys Thr Val Gly Glu Ile Thr Asp Ala 
        595                 600                 605             


Leu Lys Lys Val Phe Gly Glu His Lys Ala Asn Asp Arg Met Val Ser 
    610                 615                 620                 


Gly Ala Tyr Arg Gln Glu Phe Gly Glu Ser Lys Glu Ile Thr Ser Ala 
625                 630                 635                 640 


Ile Lys Arg Val His Lys Phe Met Glu Arg Glu Gly Arg Arg Pro Arg 
                645                 650                 655     


Leu Leu Val Ala Lys Met Gly Gln Asp Gly His Asp Arg Gly Ala Lys 
            660                 665                 670         


Val Ile Ala Thr Gly Phe Ala Asp Leu Gly Phe Asp Val Asp Ile Gly 
        675                 680                 685             


Pro Leu Phe Gln Thr Pro Arg Glu Val Ala Gln Gln Ala Val Asp Ala 
    690                 695                 700                 


Asp Val His Ala Val Gly Ile Ser Thr Leu Ala Ala Gly His Lys Thr 
705                 710                 715                 720 


Leu Val Pro Glu Leu Ile Lys Glu Leu Asn Ser Leu Gly Arg Pro Asp 
                725                 730                 735     


Ile Leu Val Met Cys Gly Gly Val Ile Pro Pro Gln Asp Tyr Glu Phe 
            740                 745                 750         


Leu Phe Glu Val Gly Val Ser Asn Val Phe Gly Pro Gly Thr Arg Ile 
        755                 760                 765             


Pro Lys Ala Ala Val Gln Val Leu Asp Asp Ile Glu Lys Cys Leu Glu 
    770                 775                 780                 


Lys Lys Gln Gln Ser Val 
785                 790 


<210>  21
<211>  787
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  21

Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser His Met Arg Lys Lys Arg Arg Gln Arg Arg Arg Gly Ser 
            20                  25                  30          


Asp Pro Gln Ser Trp Ser Arg Val Tyr Cys Ser Leu Ala Lys Arg Gly 
        35                  40                  45              


His Phe Asn Arg Ile Ser His Gly Leu Gln Gly Leu Ser Ala Val Pro 
    50                  55                  60                  


Leu Arg Thr Tyr Ala Leu His Gln Gln Gln Pro Leu His Pro Glu Trp 
65                  70                  75                  80  


Ala Ala Leu Ala Lys Lys Gln Leu Lys Gly Lys Asn Pro Glu Asp Leu 
                85                  90                  95      


Ile Trp His Thr Pro Glu Gly Ile Ser Ile Lys Pro Leu Tyr Ser Lys 
            100                 105                 110         


Arg Asp Thr Met Asp Leu Pro Glu Glu Leu Pro Gly Val Lys Pro Phe 
        115                 120                 125             


Thr Arg Gly Pro Tyr Pro Thr Met Tyr Thr Phe Arg Pro Trp Thr Ile 
    130                 135                 140                 


Arg Gln Tyr Ala Gly Phe Ser Thr Val Glu Glu Ser Asn Lys Phe Tyr 
145                 150                 155                 160 


Lys Asp Asn Ile Lys Ala Gly Gln Gln Gly Leu Ser Val Ala Phe Asp 
                165                 170                 175     


Leu Ala Thr His Arg Gly Tyr Asp Ser Asp Asn Pro Arg Val Arg Gly 
            180                 185                 190         


Asp Val Gly Met Ala Gly Val Ala Ile Asp Thr Val Glu Asp Thr Lys 
        195                 200                 205             


Ile Leu Phe Asp Gly Ile Pro Leu Glu Lys Met Ser Val Ser Met Thr 
    210                 215                 220                 


Met Asn Gly Ala Val Ile Pro Val Leu Ala Asn Phe Ile Val Thr Gly 
225                 230                 235                 240 


Glu Glu Gln Gly Val Pro Lys Glu Lys Leu Thr Gly Thr Ile Gln Asn 
                245                 250                 255     


Asp Ile Leu Lys Glu Phe Met Val Arg Asn Thr Tyr Ile Phe Pro Pro 
            260                 265                 270         


Glu Pro Ser Met Lys Ile Ile Ala Asp Ile Phe Glu Tyr Thr Ala Lys 
        275                 280                 285             


His Met Pro Lys Phe Asn Ser Ile Ser Ile Ser Gly Tyr His Met Gln 
    290                 295                 300                 


Glu Ala Gly Ala Asp Ala Ile Leu Glu Leu Ala Tyr Thr Leu Ala Asp 
305                 310                 315                 320 


Gly Leu Glu Tyr Ser Arg Thr Gly Leu Gln Ala Gly Leu Thr Ile Asp 
                325                 330                 335     


Glu Phe Ala Pro Arg Leu Ser Phe Phe Trp Gly Ile Gly Met Asn Phe 
            340                 345                 350         


Tyr Met Glu Ile Ala Lys Met Arg Ala Gly Arg Arg Leu Trp Ala His 
        355                 360                 365             


Leu Ile Glu Lys Met Phe Gln Pro Lys Asn Ser Lys Ser Leu Leu Leu 
    370                 375                 380                 


Arg Ala His Cys Gln Thr Ser Gly Trp Ser Leu Thr Glu Gln Asp Pro 
385                 390                 395                 400 


Tyr Asn Asn Ile Val Arg Thr Ala Ile Glu Ala Met Ala Ala Val Phe 
                405                 410                 415     


Gly Gly Thr Gln Ser Leu His Thr Asn Ser Phe Asp Glu Ala Leu Gly 
            420                 425                 430         


Leu Pro Thr Val Lys Ser Ala Arg Ile Ala Arg Asn Thr Gln Ile Ile 
        435                 440                 445             


Ile Gln Glu Glu Ser Gly Ile Pro Lys Val Ala Asp Pro Trp Gly Gly 
    450                 455                 460                 


Ser Tyr Met Met Glu Cys Leu Thr Asn Asp Val Tyr Asp Ala Ala Leu 
465                 470                 475                 480 


Lys Leu Ile Asn Glu Ile Glu Glu Met Gly Gly Met Ala Lys Ala Val 
                485                 490                 495     


Ala Glu Gly Ile Pro Lys Leu Arg Ile Glu Glu Cys Ala Ala Arg Arg 
            500                 505                 510         


Gln Ala Arg Ile Asp Ser Gly Ser Glu Val Ile Val Gly Val Asn Lys 
        515                 520                 525             


Tyr Gln Leu Glu Lys Glu Asp Ala Val Glu Val Leu Ala Ile Asp Asn 
    530                 535                 540                 


Thr Ser Val Arg Asn Arg Gln Ile Glu Lys Leu Lys Lys Ile Lys Ser 
545                 550                 555                 560 


Ser Arg Asp Gln Ala Leu Ala Glu Arg Cys Leu Ala Ala Leu Thr Glu 
                565                 570                 575     


Cys Ala Ala Ser Gly Asp Gly Asn Ile Leu Ala Leu Ala Val Asp Ala 
            580                 585                 590         


Ser Arg Ala Arg Cys Thr Val Gly Glu Ile Thr Asp Ala Leu Lys Lys 
        595                 600                 605             


Val Phe Gly Glu His Lys Ala Asn Asp Arg Met Val Ser Gly Ala Tyr 
    610                 615                 620                 


Arg Gln Glu Phe Gly Glu Ser Lys Glu Ile Thr Ser Ala Ile Lys Arg 
625                 630                 635                 640 


Val His Lys Phe Met Glu Arg Glu Gly Arg Arg Pro Arg Leu Leu Val 
                645                 650                 655     


Ala Lys Met Gly Gln Asp Gly His Asp Arg Gly Ala Lys Val Ile Ala 
            660                 665                 670         


Thr Gly Phe Ala Asp Leu Gly Phe Asp Val Asp Ile Gly Pro Leu Phe 
        675                 680                 685             


Gln Thr Pro Arg Glu Val Ala Gln Gln Ala Val Asp Ala Asp Val His 
    690                 695                 700                 


Ala Val Gly Ile Ser Thr Leu Ala Ala Gly His Lys Thr Leu Val Pro 
705                 710                 715                 720 


Glu Leu Ile Lys Glu Leu Asn Ser Leu Gly Arg Pro Asp Ile Leu Val 
                725                 730                 735     


Met Cys Gly Gly Val Ile Pro Pro Gln Asp Tyr Glu Phe Leu Phe Glu 
            740                 745                 750         


Val Gly Val Ser Asn Val Phe Gly Pro Gly Thr Arg Ile Pro Lys Ala 
        755                 760                 765             


Ala Val Gln Val Leu Asp Asp Ile Glu Lys Cys Leu Glu Lys Lys Gln 
    770                 775                 780                 


Gln Ser Val 
785         


<210>  22
<211>  1159
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  22

Met Gly Ser Ser His His His His His His Gly Ser Ser Met Lys Ile 
1               5                   10                  15      


Glu Glu Gly Lys Leu Val Ile Trp Ile Asn Gly Asp Lys Gly Tyr Asn 
            20                  25                  30          


Gly Leu Ala Glu Val Gly Lys Lys Phe Glu Lys Asp Thr Gly Ile Lys 
        35                  40                  45              


Val Thr Val Glu His Pro Asp Lys Leu Glu Glu Lys Phe Pro Gln Val 
    50                  55                  60                  


Ala Ala Thr Gly Asp Gly Pro Asp Ile Ile Phe Trp Ala His Asp Arg 
65                  70                  75                  80  


Phe Gly Gly Tyr Ala Gln Ser Gly Leu Leu Ala Glu Ile Thr Pro Asp 
                85                  90                  95      


Lys Ala Phe Gln Asp Lys Leu Tyr Pro Phe Thr Trp Asp Ala Val Arg 
            100                 105                 110         


Tyr Asn Gly Lys Leu Ile Ala Tyr Pro Ile Ala Val Glu Ala Leu Ser 
        115                 120                 125             


Leu Ile Tyr Asn Lys Asp Leu Leu Pro Asn Pro Pro Lys Thr Trp Glu 
    130                 135                 140                 


Glu Ile Pro Ala Leu Asp Lys Glu Leu Lys Ala Lys Gly Lys Ser Ala 
145                 150                 155                 160 


Leu Met Phe Asn Leu Gln Glu Pro Tyr Phe Thr Trp Pro Leu Ile Ala 
                165                 170                 175     


Ala Asp Gly Gly Tyr Ala Phe Lys Tyr Glu Asn Gly Lys Tyr Asp Ile 
            180                 185                 190         


Lys Asp Val Gly Val Asp Asn Ala Gly Ala Lys Ala Gly Leu Thr Phe 
        195                 200                 205             


Leu Val Asp Leu Ile Lys Asn Lys His Met Asn Ala Asp Thr Asp Tyr 
    210                 215                 220                 


Ser Ile Ala Glu Ala Ala Phe Asn Lys Gly Glu Thr Ala Met Thr Ile 
225                 230                 235                 240 


Asn Gly Pro Trp Ala Trp Ser Asn Ile Asp Thr Ser Lys Val Asn Tyr 
                245                 250                 255     


Gly Val Thr Val Leu Pro Thr Phe Lys Gly Gln Pro Ser Lys Pro Phe 
            260                 265                 270         


Val Gly Val Leu Ser Ala Gly Ile Asn Ala Ala Ser Pro Asn Lys Glu 
        275                 280                 285             


Leu Ala Lys Glu Phe Leu Glu Asn Tyr Leu Leu Thr Asp Glu Gly Leu 
    290                 295                 300                 


Glu Ala Val Asn Lys Asp Lys Pro Leu Gly Ala Val Ala Leu Lys Ser 
305                 310                 315                 320 


Tyr Glu Glu Glu Leu Ala Lys Asp Pro Arg Ile Ala Ala Thr Met Glu 
                325                 330                 335     


Asn Ala Gln Lys Gly Glu Ile Met Pro Asn Ile Pro Gln Met Ser Ala 
            340                 345                 350         


Phe Trp Tyr Ala Val Arg Thr Ala Val Ile Asn Ala Ala Ser Gly Arg 
        355                 360                 365             


Gln Thr Val Asp Glu Ala Leu Lys Asp Ala Gln Thr Asn Gly Ile Glu 
    370                 375                 380                 


Glu Asn Leu Tyr Phe Gln Ser Asn Ile Arg Lys Lys Arg Arg Gln Arg 
385                 390                 395                 400 


Arg Arg Gly Ser Asp Pro Asn Ser Ser Ser Leu Arg Ala Lys Asn Gln 
                405                 410                 415     


Leu Phe Leu Leu Ser Pro His Tyr Leu Arg Gln Val Lys Glu Ser Ser 
            420                 425                 430         


Gly Ser Arg Leu Ile Gln Gln Arg Leu Leu His Gln Gln Gln Pro Leu 
        435                 440                 445             


His Pro Glu Trp Ala Ala Leu Ala Lys Lys Gln Leu Lys Gly Lys Asn 
    450                 455                 460                 


Pro Glu Asp Leu Ile Trp His Thr Pro Glu Gly Ile Ser Ile Lys Pro 
465                 470                 475                 480 


Leu Tyr Ser Lys Arg Asp Thr Met Asp Leu Pro Glu Glu Leu Pro Gly 
                485                 490                 495     


Val Lys Pro Phe Thr Arg Gly Pro Tyr Pro Thr Met Tyr Thr Phe Arg 
            500                 505                 510         


Pro Trp Thr Ile Arg Gln Tyr Ala Gly Phe Ser Thr Val Glu Glu Ser 
        515                 520                 525             


Asn Lys Phe Tyr Lys Asp Asn Ile Lys Ala Gly Gln Gln Gly Leu Ser 
    530                 535                 540                 


Val Ala Phe Asp Leu Ala Thr His Arg Gly Tyr Asp Ser Asp Asn Pro 
545                 550                 555                 560 


Arg Val Arg Gly Asp Val Gly Met Ala Gly Val Ala Ile Asp Thr Val 
                565                 570                 575     


Glu Asp Thr Lys Ile Leu Phe Asp Gly Ile Pro Leu Glu Lys Met Ser 
            580                 585                 590         


Val Ser Met Thr Met Asn Gly Ala Val Ile Pro Val Leu Ala Asn Phe 
        595                 600                 605             


Ile Val Thr Gly Glu Glu Gln Gly Val Pro Lys Glu Lys Leu Thr Gly 
    610                 615                 620                 


Thr Ile Gln Asn Asp Ile Leu Lys Glu Phe Met Val Arg Asn Thr Tyr 
625                 630                 635                 640 


Ile Phe Pro Pro Glu Pro Ser Met Lys Ile Ile Ala Asp Ile Phe Glu 
                645                 650                 655     


Tyr Thr Ala Lys His Met Pro Lys Phe Asn Ser Ile Ser Ile Ser Gly 
            660                 665                 670         


Tyr His Met Gln Glu Ala Gly Ala Asp Ala Ile Leu Glu Leu Ala Tyr 
        675                 680                 685             


Thr Leu Ala Asp Gly Leu Glu Tyr Ser Arg Thr Gly Leu Gln Ala Gly 
    690                 695                 700                 


Leu Thr Ile Asp Glu Phe Ala Pro Arg Leu Ser Phe Phe Trp Gly Ile 
705                 710                 715                 720 


Gly Met Asn Phe Tyr Met Glu Ile Ala Lys Met Arg Ala Gly Arg Arg 
                725                 730                 735     


Leu Trp Ala His Leu Ile Glu Lys Met Phe Gln Pro Lys Asn Ser Lys 
            740                 745                 750         


Ser Leu Leu Leu Arg Ala His Cys Gln Thr Ser Gly Trp Ser Leu Thr 
        755                 760                 765             


Glu Gln Asp Pro Tyr Asn Asn Ile Val Arg Thr Ala Ile Glu Ala Met 
    770                 775                 780                 


Ala Ala Val Phe Gly Gly Thr Gln Ser Leu His Thr Asn Ser Phe Asp 
785                 790                 795                 800 


Glu Ala Leu Gly Leu Pro Thr Val Lys Ser Ala Arg Ile Ala Arg Asn 
                805                 810                 815     


Thr Gln Ile Ile Ile Gln Glu Glu Ser Gly Ile Pro Lys Val Ala Asp 
            820                 825                 830         


Pro Trp Gly Gly Ser Tyr Met Met Glu Cys Leu Thr Asn Asp Val Tyr 
        835                 840                 845             


Asp Ala Ala Leu Lys Leu Ile Asn Glu Ile Glu Glu Met Gly Gly Met 
    850                 855                 860                 


Ala Lys Ala Val Ala Glu Gly Ile Pro Lys Leu Arg Ile Glu Glu Cys 
865                 870                 875                 880 


Ala Ala Arg Arg Gln Ala Arg Ile Asp Ser Gly Ser Glu Val Ile Val 
                885                 890                 895     


Gly Val Asn Lys Tyr Gln Leu Glu Lys Glu Asp Ala Val Glu Val Leu 
            900                 905                 910         


Ala Ile Asp Asn Thr Ser Val Arg Asn Arg Gln Ile Glu Lys Leu Lys 
        915                 920                 925             


Lys Ile Lys Ser Ser Arg Asp Gln Ala Leu Ala Glu Arg Cys Leu Ala 
    930                 935                 940                 


Ala Leu Thr Glu Cys Ala Ala Ser Gly Asp Gly Asn Ile Leu Ala Leu 
945                 950                 955                 960 


Ala Val Asp Ala Ser Arg Ala Arg Cys Thr Val Gly Glu Ile Thr Asp 
                965                 970                 975     


Ala Leu Lys Lys Val Phe Gly Glu His Lys Ala Asn Asp Arg Met Val 
            980                 985                 990         


Ser Gly Ala Tyr Arg Gln Glu Phe  Gly Glu Ser Lys Glu  Ile Thr Ser 
        995                 1000                 1005             


Ala Ile  Lys Arg Val His Lys  Phe Met Glu Arg Glu  Gly Arg Arg 
    1010                 1015                 1020             


Pro Arg  Leu Leu Val Ala Lys  Met Gly Gln Asp Gly  His Asp Arg 
    1025                 1030                 1035             


Gly Ala  Lys Val Ile Ala Thr  Gly Phe Ala Asp Leu  Gly Phe Asp 
    1040                 1045                 1050             


Val Asp  Ile Gly Pro Leu Phe  Gln Thr Pro Arg Glu  Val Ala Gln 
    1055                 1060                 1065             


Gln Ala  Val Asp Ala Asp Val  His Ala Val Gly Ile  Ser Thr Leu 
    1070                 1075                 1080             


Ala Ala  Gly His Lys Thr Leu  Val Pro Glu Leu Ile  Lys Glu Leu 
    1085                 1090                 1095             


Asn Ser  Leu Gly Arg Pro Asp  Ile Leu Val Met Cys  Gly Gly Val 
    1100                 1105                 1110             


Ile Pro  Pro Gln Asp Tyr Glu  Phe Leu Phe Glu Val  Gly Val Ser 
    1115                 1120                 1125             


Asn Val  Phe Gly Pro Gly Thr  Arg Ile Pro Lys Ala  Ala Val Gln 
    1130                 1135                 1140             


Val Leu  Asp Asp Ile Glu Lys  Cys Leu Glu Lys Lys  Gln Gln Ser 
    1145                 1150                 1155             


Val 
    


<210>  23
<211>  756
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  23

Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser His Met Arg Lys Lys Arg Arg Gln Arg Arg Arg Gly Ser 
            20                  25                  30          


Asp Pro Asn Ser Ser Ser Leu His Gln Gln Gln Pro Leu His Pro Glu 
        35                  40                  45              


Trp Ala Ala Leu Ala Lys Lys Gln Leu Lys Gly Lys Asn Pro Glu Asp 
    50                  55                  60                  


Leu Ile Trp His Thr Pro Glu Gly Ile Ser Ile Lys Pro Leu Tyr Ser 
65                  70                  75                  80  


Lys Arg Asp Thr Met Asp Leu Pro Glu Glu Leu Pro Gly Val Lys Pro 
                85                  90                  95      


Phe Thr Arg Gly Pro Tyr Pro Thr Met Tyr Thr Phe Arg Pro Trp Thr 
            100                 105                 110         


Ile Arg Gln Tyr Ala Gly Phe Ser Thr Val Glu Glu Ser Asn Lys Phe 
        115                 120                 125             


Tyr Lys Asp Asn Ile Lys Ala Gly Gln Gln Gly Leu Ser Val Ala Phe 
    130                 135                 140                 


Asp Leu Ala Thr His Arg Gly Tyr Asp Ser Asp Asn Pro Arg Val Arg 
145                 150                 155                 160 


Gly Asp Val Gly Met Ala Gly Val Ala Ile Asp Thr Val Glu Asp Thr 
                165                 170                 175     


Lys Ile Leu Phe Asp Gly Ile Pro Leu Glu Lys Met Ser Val Ser Met 
            180                 185                 190         


Thr Met Asn Gly Ala Val Ile Pro Val Leu Ala Asn Phe Ile Val Thr 
        195                 200                 205             


Gly Glu Glu Gln Gly Val Pro Lys Glu Lys Leu Thr Gly Thr Ile Gln 
    210                 215                 220                 


Asn Asp Ile Leu Lys Glu Phe Met Val Arg Asn Thr Tyr Ile Phe Pro 
225                 230                 235                 240 


Pro Glu Pro Ser Met Lys Ile Ile Ala Asp Ile Phe Glu Tyr Thr Ala 
                245                 250                 255     


Lys His Met Pro Lys Phe Asn Ser Ile Ser Ile Ser Gly Tyr His Met 
            260                 265                 270         


Gln Glu Ala Gly Ala Asp Ala Ile Leu Glu Leu Ala Tyr Thr Leu Ala 
        275                 280                 285             


Asp Gly Leu Glu Tyr Ser Arg Thr Gly Leu Gln Ala Gly Leu Thr Ile 
    290                 295                 300                 


Asp Glu Phe Ala Pro Arg Leu Ser Phe Phe Trp Gly Ile Gly Met Asn 
305                 310                 315                 320 


Phe Tyr Met Glu Ile Ala Lys Met Arg Ala Gly Arg Arg Leu Trp Ala 
                325                 330                 335     


His Leu Ile Glu Lys Met Phe Gln Pro Lys Asn Ser Lys Ser Leu Leu 
            340                 345                 350         


Leu Arg Ala His Cys Gln Thr Ser Gly Trp Ser Leu Thr Glu Gln Asp 
        355                 360                 365             


Pro Tyr Asn Asn Ile Val Arg Thr Ala Ile Glu Ala Met Ala Ala Val 
    370                 375                 380                 


Phe Gly Gly Thr Gln Ser Leu His Thr Asn Ser Phe Asp Glu Ala Leu 
385                 390                 395                 400 


Gly Leu Pro Thr Val Lys Ser Ala Arg Ile Ala Arg Asn Thr Gln Ile 
                405                 410                 415     


Ile Ile Gln Glu Glu Ser Gly Ile Pro Lys Val Ala Asp Pro Trp Gly 
            420                 425                 430         


Gly Ser Tyr Met Met Glu Cys Leu Thr Asn Asp Val Tyr Asp Ala Ala 
        435                 440                 445             


Leu Lys Leu Ile Asn Glu Ile Glu Glu Met Gly Gly Met Ala Lys Ala 
    450                 455                 460                 


Val Ala Glu Gly Ile Pro Lys Leu Arg Ile Glu Glu Cys Ala Ala Arg 
465                 470                 475                 480 


Arg Gln Ala Arg Ile Asp Ser Gly Ser Glu Val Ile Val Gly Val Asn 
                485                 490                 495     


Lys Tyr Gln Leu Glu Lys Glu Asp Ala Val Glu Val Leu Ala Ile Asp 
            500                 505                 510         


Asn Thr Ser Val Arg Asn Arg Gln Ile Glu Lys Leu Lys Lys Ile Lys 
        515                 520                 525             


Ser Ser Arg Asp Gln Ala Leu Ala Glu Arg Cys Leu Ala Ala Leu Thr 
    530                 535                 540                 


Glu Cys Ala Ala Ser Gly Asp Gly Asn Ile Leu Ala Leu Ala Val Asp 
545                 550                 555                 560 


Ala Ser Arg Ala Arg Cys Thr Val Gly Glu Ile Thr Asp Ala Leu Lys 
                565                 570                 575     


Lys Val Phe Gly Glu His Lys Ala Asn Asp Arg Met Val Ser Gly Ala 
            580                 585                 590         


Tyr Arg Gln Glu Phe Gly Glu Ser Lys Glu Ile Thr Ser Ala Ile Lys 
        595                 600                 605             


Arg Val His Lys Phe Met Glu Arg Glu Gly Arg Arg Pro Arg Leu Leu 
    610                 615                 620                 


Val Ala Lys Met Gly Gln Asp Gly His Asp Arg Gly Ala Lys Val Ile 
625                 630                 635                 640 


Ala Thr Gly Phe Ala Asp Leu Gly Phe Asp Val Asp Ile Gly Pro Leu 
                645                 650                 655     


Phe Gln Thr Pro Arg Glu Val Ala Gln Gln Ala Val Asp Ala Asp Val 
            660                 665                 670         


His Ala Val Gly Ile Ser Thr Leu Ala Ala Gly His Lys Thr Leu Val 
        675                 680                 685             


Pro Glu Leu Ile Lys Glu Leu Asn Ser Leu Gly Arg Pro Asp Ile Leu 
    690                 695                 700                 


Val Met Cys Gly Gly Val Ile Pro Pro Gln Asp Tyr Glu Phe Leu Phe 
705                 710                 715                 720 


Glu Val Gly Val Ser Asn Val Phe Gly Pro Gly Thr Arg Ile Pro Lys 
                725                 730                 735     


Ala Ala Val Gln Val Leu Asp Asp Ile Glu Lys Cys Leu Glu Lys Lys 
            740                 745                 750         


Gln Gln Ser Val 
        755     


