SEQUENCE LISTING

<110>  CELLECTIS
    

<120>  A METHOD OF ENGINEERING PRODRUG-SPECIFIC HYPERSENSITIVE T-CELLS FOR IMMUNOTHERAPY BY GENE EXPRESSION

<130>  P81601867PCT00

<150>  PA201670233
<151>  2016-04-15

<160>  27


<210>  1

<211>  146
<212>  PRT
<213>  Homo sapiens

<220>
<223>  cytidine deaminase CDA

<400>  1
Met Ala Gln Lys Arg Pro Ala Cys Thr Leu Lys Pro Glu Cys Val Gln 
1               5                   10                  15      


Gln Leu Leu Val Cys Ser Gln Glu Ala Lys Lys Ser Ala Tyr Cys Pro 
            20                  25                  30          


Tyr Ser His Phe Pro Val Gly Ala Ala Leu Leu Thr Gln Glu Gly Arg 
        35                  40                  45              


Ile Phe Lys Gly Cys Asn Ile Glu Asn Ala Cys Tyr Pro Leu Gly Ile 
    50                  55                  60                  


Cys Ala Glu Arg Thr Ala Ile Gln Lys Ala Val Ser Glu Gly Tyr Lys 
65                  70                  75                  80  


Asp Phe Arg Ala Ile Ala Ile Ala Ser Asp Met Gln Asp Asp Phe Ile 
                85                  90                  95      


Ser Pro Cys Gly Ala Cys Arg Gln Val Met Arg Glu Phe Gly Thr Asn 
            100                 105                 110         


Trp Pro Val Tyr Met Thr Lys Pro Asp Gly Thr Tyr Ile Val Met Thr 
        115                 120                 125             


Val Gln Glu Leu Leu Pro Ser Ser Phe Gly Pro Glu Asp Leu Gln Lys 
    130                 135                 140                 


Thr Gln 
145     


<210>  2

<211>  497
<212>  PRT
<213>  Homo sapiens

<220>
<223>  P450 isozyme CYP2D6_2

<400>  2
Met Gly Leu Glu Ala Leu Val Pro Leu Ala Val Ile Val Ala Ile Phe 
1               5                   10                  15      


Leu Leu Leu Val Asp Leu Met His Arg Arg Gln Arg Trp Ala Ala Arg 
            20                  25                  30          


Tyr Pro Pro Gly Pro Leu Pro Leu Pro Gly Leu Gly Asn Leu Leu His 
        35                  40                  45              


Val Asp Phe Gln Asn Thr Pro Tyr Cys Phe Asp Gln Leu Arg Arg Arg 
    50                  55                  60                  


Phe Gly Asp Val Phe Ser Leu Gln Leu Ala Trp Thr Pro Val Val Val 
65                  70                  75                  80  


Leu Asn Gly Leu Ala Ala Val Arg Glu Ala Leu Val Thr His Gly Glu 
                85                  90                  95      


Asp Thr Ala Asp Arg Pro Pro Val Pro Ile Thr Gln Ile Leu Gly Phe 
            100                 105                 110         


Gly Pro Arg Ser Gln Gly Val Phe Leu Ala Arg Tyr Gly Pro Ala Trp 
        115                 120                 125             


Arg Glu Gln Arg Arg Phe Ser Val Ser Thr Leu Arg Asn Leu Gly Leu 
    130                 135                 140                 


Gly Lys Lys Ser Leu Glu Gln Trp Val Thr Glu Glu Ala Ala Cys Leu 
145                 150                 155                 160 


Cys Ala Ala Phe Ala Asn His Ser Gly Arg Pro Phe Arg Pro Asn Gly 
                165                 170                 175     


Leu Leu Asp Lys Ala Val Ser Asn Val Ile Ala Ser Leu Thr Cys Gly 
            180                 185                 190         


Arg Arg Phe Glu Tyr Asp Asp Pro Arg Phe Leu Arg Leu Leu Asp Leu 
        195                 200                 205             


Ala Gln Glu Gly Leu Lys Glu Glu Ser Gly Phe Leu Arg Glu Val Leu 
    210                 215                 220                 


Asn Ala Val Pro Val Leu Leu His Ile Pro Ala Leu Ala Gly Lys Val 
225                 230                 235                 240 


Leu Arg Phe Gln Lys Ala Phe Leu Thr Gln Leu Asp Glu Leu Leu Thr 
                245                 250                 255     


Glu His Arg Met Thr Trp Asp Pro Ala Gln Pro Pro Arg Asp Leu Thr 
            260                 265                 270         


Glu Ala Phe Leu Ala Glu Met Glu Lys Ala Lys Gly Asn Pro Glu Ser 
        275                 280                 285             


Ser Phe Asn Asp Glu Asn Leu Cys Ile Val Val Ala Asp Leu Phe Ser 
    290                 295                 300                 


Ala Gly Met Val Thr Thr Ser Thr Thr Leu Ala Trp Gly Leu Leu Leu 
305                 310                 315                 320 


Met Ile Leu His Pro Asp Val Gln Arg Arg Val Gln Gln Glu Ile Asp 
                325                 330                 335     


Asp Val Ile Gly Gln Val Arg Arg Pro Glu Met Gly Asp Gln Ala His 
            340                 345                 350         


Met Pro Tyr Thr Thr Ala Val Ile His Glu Val Gln Arg Phe Gly Asp 
        355                 360                 365             


Ile Val Pro Leu Gly Val Thr His Met Thr Ser Arg Asp Ile Glu Val 
    370                 375                 380                 


Gln Gly Phe Arg Ile Pro Lys Gly Thr Thr Leu Ile Thr Asn Leu Ser 
385                 390                 395                 400 


Ser Val Leu Lys Asp Glu Ala Val Trp Glu Lys Pro Phe Arg Phe His 
                405                 410                 415     


Pro Glu His Phe Leu Asp Ala Gln Gly His Phe Val Lys Pro Glu Ala 
            420                 425                 430         


Phe Leu Pro Phe Ser Ala Gly Arg Arg Ala Cys Leu Gly Glu Pro Leu 
        435                 440                 445             


Ala Arg Met Glu Leu Phe Leu Phe Phe Thr Ser Leu Leu Gln His Phe 
    450                 455                 460                 


Ser Phe Ser Val Pro Thr Gly Gln Pro Arg Pro Ser His His Gly Val 
465                 470                 475                 480 


Phe Ala Phe Leu Val Thr Pro Ser Pro Tyr Glu Leu Cys Ala Val Pro 
                485                 490                 495     


Arg 
    


<210>  3

<211>  490
<212>  PRT
<213>  Homo sapiens

<220>
<223>  P450 isozyme CYP2C9

<400>  3
Met Asp Ser Leu Val Val Leu Val Leu Cys Leu Ser Cys Leu Leu Leu 
1               5                   10                  15      


Leu Ser Leu Trp Arg Gln Ser Ser Gly Arg Gly Lys Leu Pro Pro Gly 
            20                  25                  30          


Pro Thr Pro Leu Pro Val Ile Gly Asn Ile Leu Gln Ile Gly Ile Lys 
        35                  40                  45              


Asp Ile Ser Lys Ser Leu Thr Asn Leu Ser Lys Val Tyr Gly Pro Val 
    50                  55                  60                  


Phe Thr Leu Tyr Phe Gly Leu Lys Pro Ile Val Val Leu His Gly Tyr 
65                  70                  75                  80  


Glu Ala Val Lys Glu Ala Leu Ile Asp Leu Gly Glu Glu Phe Ser Gly 
                85                  90                  95      


Arg Gly Ile Phe Pro Leu Ala Glu Arg Ala Asn Arg Gly Phe Gly Ile 
            100                 105                 110         


Val Phe Ser Asn Gly Lys Lys Trp Lys Glu Ile Arg Arg Phe Ser Leu 
        115                 120                 125             


Met Thr Leu Arg Asn Phe Gly Met Gly Lys Arg Ser Ile Glu Asp Arg 
    130                 135                 140                 


Val Gln Glu Glu Ala Arg Cys Leu Val Glu Glu Leu Arg Lys Thr Lys 
145                 150                 155                 160 


Ala Ser Pro Cys Asp Pro Thr Phe Ile Leu Gly Cys Ala Pro Cys Asn 
                165                 170                 175     


Val Ile Cys Ser Ile Ile Phe His Lys Arg Phe Asp Tyr Lys Asp Gln 
            180                 185                 190         


Gln Phe Leu Asn Leu Met Glu Lys Leu Asn Glu Asn Ile Lys Ile Leu 
        195                 200                 205             


Ser Ser Pro Trp Ile Gln Ile Cys Asn Asn Phe Ser Pro Ile Ile Asp 
    210                 215                 220                 


Tyr Phe Pro Gly Thr His Asn Lys Leu Leu Lys Asn Val Ala Phe Met 
225                 230                 235                 240 


Lys Ser Tyr Ile Leu Glu Lys Val Lys Glu His Gln Glu Ser Met Asp 
                245                 250                 255     


Met Asn Asn Pro Gln Asp Phe Ile Asp Cys Phe Leu Met Lys Met Glu 
            260                 265                 270         


Lys Glu Lys His Asn Gln Pro Ser Glu Phe Thr Ile Glu Ser Leu Glu 
        275                 280                 285             


Asn Thr Ala Val Asp Leu Phe Gly Ala Gly Thr Glu Thr Thr Ser Thr 
    290                 295                 300                 


Thr Leu Arg Tyr Ala Leu Leu Leu Leu Leu Lys His Pro Glu Val Thr 
305                 310                 315                 320 


Ala Lys Val Gln Glu Glu Ile Glu Arg Val Ile Gly Arg Asn Arg Ser 
                325                 330                 335     


Pro Cys Met Gln Asp Arg Ser His Met Pro Tyr Thr Asp Ala Val Val 
            340                 345                 350         


His Glu Val Gln Arg Tyr Ile Asp Leu Leu Pro Thr Ser Leu Pro His 
        355                 360                 365             


Ala Val Thr Cys Asp Ile Lys Phe Arg Asn Tyr Leu Ile Pro Lys Gly 
    370                 375                 380                 


Thr Thr Ile Leu Ile Ser Leu Thr Ser Val Leu His Asp Asn Lys Glu 
385                 390                 395                 400 


Phe Pro Asn Pro Glu Met Phe Asp Pro His His Phe Leu Asp Glu Gly 
                405                 410                 415     


Gly Asn Phe Lys Lys Ser Lys Tyr Phe Met Pro Phe Ser Ala Gly Lys 
            420                 425                 430         


Arg Ile Cys Val Gly Glu Ala Leu Ala Gly Met Glu Leu Phe Leu Phe 
        435                 440                 445             


Leu Thr Ser Ile Leu Gln Asn Phe Asn Leu Lys Ser Leu Val Asp Pro 
    450                 455                 460                 


Lys Asn Leu Asp Thr Thr Pro Val Val Asn Gly Phe Ala Ser Val Pro 
465                 470                 475                 480 


Pro Phe Tyr Gln Leu Cys Phe Ile Pro Val 
                485                 490 


<210>  4

<211>  503
<212>  PRT
<213>  Homo sapiens

<220>
<223>  P450 isozyme CYP3A4

<400>  4
Met Ala Leu Ile Pro Asp Leu Ala Met Glu Thr Trp Leu Leu Leu Ala 
1               5                   10                  15      


Val Ser Leu Val Leu Leu Tyr Leu Tyr Gly Thr His Ser His Gly Leu 
            20                  25                  30          


Phe Lys Lys Leu Gly Ile Pro Gly Pro Thr Pro Leu Pro Phe Leu Gly 
        35                  40                  45              


Asn Ile Leu Ser Tyr His Lys Gly Phe Cys Met Phe Asp Met Glu Cys 
    50                  55                  60                  


His Lys Lys Tyr Gly Lys Val Trp Gly Phe Tyr Asp Gly Gln Gln Pro 
65                  70                  75                  80  


Val Leu Ala Ile Thr Asp Pro Asp Met Ile Lys Thr Val Leu Val Lys 
                85                  90                  95      


Glu Cys Tyr Ser Val Phe Thr Asn Arg Arg Pro Phe Gly Pro Val Gly 
            100                 105                 110         


Phe Met Lys Ser Ala Ile Ser Ile Ala Glu Asp Glu Glu Trp Lys Arg 
        115                 120                 125             


Leu Arg Ser Leu Leu Ser Pro Thr Phe Thr Ser Gly Lys Leu Lys Glu 
    130                 135                 140                 


Met Val Pro Ile Ile Ala Gln Tyr Gly Asp Val Leu Val Arg Asn Leu 
145                 150                 155                 160 


Arg Arg Glu Ala Glu Thr Gly Lys Pro Val Thr Leu Lys Asp Val Phe 
                165                 170                 175     


Gly Ala Tyr Ser Met Asp Val Ile Thr Ser Thr Ser Phe Gly Val Asn 
            180                 185                 190         


Ile Asp Ser Leu Asn Asn Pro Gln Asp Pro Phe Val Glu Asn Thr Lys 
        195                 200                 205             


Lys Leu Leu Arg Phe Asp Phe Leu Asp Pro Phe Phe Leu Ser Ile Thr 
    210                 215                 220                 


Val Phe Pro Phe Leu Ile Pro Ile Leu Glu Val Leu Asn Ile Cys Val 
225                 230                 235                 240 


Phe Pro Arg Glu Val Thr Asn Phe Leu Arg Lys Ser Val Lys Arg Met 
                245                 250                 255     


Lys Glu Ser Arg Leu Glu Asp Thr Gln Lys His Arg Val Asp Phe Leu 
            260                 265                 270         


Gln Leu Met Ile Asp Ser Gln Asn Ser Lys Glu Thr Glu Ser His Lys 
        275                 280                 285             


Ala Leu Ser Asp Leu Glu Leu Val Ala Gln Ser Ile Ile Phe Ile Phe 
    290                 295                 300                 


Ala Gly Tyr Glu Thr Thr Ser Ser Val Leu Ser Phe Ile Met Tyr Glu 
305                 310                 315                 320 


Leu Ala Thr His Pro Asp Val Gln Gln Lys Leu Gln Glu Glu Ile Asp 
                325                 330                 335     


Ala Val Leu Pro Asn Lys Ala Pro Pro Thr Tyr Asp Thr Val Leu Gln 
            340                 345                 350         


Met Glu Tyr Leu Asp Met Val Val Asn Glu Thr Leu Arg Leu Phe Pro 
        355                 360                 365             


Ile Ala Met Arg Leu Glu Arg Val Cys Lys Lys Asp Val Glu Ile Asn 
    370                 375                 380                 


Gly Met Phe Ile Pro Lys Gly Val Val Val Met Ile Pro Ser Tyr Ala 
385                 390                 395                 400 


Leu His Arg Asp Pro Lys Tyr Trp Thr Glu Pro Glu Lys Phe Leu Pro 
                405                 410                 415     


Glu Arg Phe Ser Lys Lys Asn Lys Asp Asn Ile Asp Pro Tyr Ile Tyr 
            420                 425                 430         


Thr Pro Phe Gly Ser Gly Pro Arg Asn Cys Ile Gly Met Arg Phe Ala 
        435                 440                 445             


Leu Met Asn Met Lys Leu Ala Leu Ile Arg Val Leu Gln Asn Phe Ser 
    450                 455                 460                 


Phe Lys Pro Cys Lys Glu Thr Gln Ile Pro Leu Lys Leu Ser Leu Gly 
465                 470                 475                 480 


Gly Leu Leu Gln Pro Glu Lys Pro Val Val Leu Lys Val Glu Ser Arg 
                485                 490                 495     


Asp Gly Thr Val Ser Gly Ala 
            500             


<210>  5

<211>  446
<212>  PRT
<213>  Homo sapiens

<220>
<223>  P450 isozyme CYP2D6_1

<400>  5
Met Gly Leu Glu Ala Leu Val Pro Leu Ala Val Ile Val Ala Ile Phe 
1               5                   10                  15      


Leu Leu Leu Val Asp Leu Met His Arg Arg Gln Arg Trp Ala Ala Arg 
            20                  25                  30          


Tyr Pro Pro Gly Pro Leu Pro Leu Pro Gly Leu Gly Asn Leu Leu His 
        35                  40                  45              


Val Asp Phe Gln Asn Thr Pro Tyr Cys Phe Asp Gln Leu Arg Arg Arg 
    50                  55                  60                  


Phe Gly Asp Val Phe Ser Leu Gln Leu Ala Trp Thr Pro Val Val Val 
65                  70                  75                  80  


Leu Asn Gly Leu Ala Ala Val Arg Glu Ala Leu Val Thr His Gly Glu 
                85                  90                  95      


Asp Thr Ala Asp Arg Pro Pro Val Pro Ile Thr Gln Ile Leu Gly Phe 
            100                 105                 110         


Gly Pro Arg Ser Gln Gly Arg Pro Phe Arg Pro Asn Gly Leu Leu Asp 
        115                 120                 125             


Lys Ala Val Ser Asn Val Ile Ala Ser Leu Thr Cys Gly Arg Arg Phe 
    130                 135                 140                 


Glu Tyr Asp Asp Pro Arg Phe Leu Arg Leu Leu Asp Leu Ala Gln Glu 
145                 150                 155                 160 


Gly Leu Lys Glu Glu Ser Gly Phe Leu Arg Glu Val Leu Asn Ala Val 
                165                 170                 175     


Pro Val Leu Leu His Ile Pro Ala Leu Ala Gly Lys Val Leu Arg Phe 
            180                 185                 190         


Gln Lys Ala Phe Leu Thr Gln Leu Asp Glu Leu Leu Thr Glu His Arg 
        195                 200                 205             


Met Thr Trp Asp Pro Ala Gln Pro Pro Arg Asp Leu Thr Glu Ala Phe 
    210                 215                 220                 


Leu Ala Glu Met Glu Lys Ala Lys Gly Asn Pro Glu Ser Ser Phe Asn 
225                 230                 235                 240 


Asp Glu Asn Leu Cys Ile Val Val Ala Asp Leu Phe Ser Ala Gly Met 
                245                 250                 255     


Val Thr Thr Ser Thr Thr Leu Ala Trp Gly Leu Leu Leu Met Ile Leu 
            260                 265                 270         


His Pro Asp Val Gln Arg Arg Val Gln Gln Glu Ile Asp Asp Val Ile 
        275                 280                 285             


Gly Gln Val Arg Arg Pro Glu Met Gly Asp Gln Ala His Met Pro Tyr 
    290                 295                 300                 


Thr Thr Ala Val Ile His Glu Val Gln Arg Phe Gly Asp Ile Val Pro 
305                 310                 315                 320 


Leu Gly Val Thr His Met Thr Ser Arg Asp Ile Glu Val Gln Gly Phe 
                325                 330                 335     


Arg Ile Pro Lys Gly Thr Thr Leu Ile Thr Asn Leu Ser Ser Val Leu 
            340                 345                 350         


Lys Asp Glu Ala Val Trp Glu Lys Pro Phe Arg Phe His Pro Glu His 
        355                 360                 365             


Phe Leu Asp Ala Gln Gly His Phe Val Lys Pro Glu Ala Phe Leu Pro 
    370                 375                 380                 


Phe Ser Ala Gly Arg Arg Ala Cys Leu Gly Glu Pro Leu Ala Arg Met 
385                 390                 395                 400 


Glu Leu Phe Leu Phe Phe Thr Ser Leu Leu Gln His Phe Ser Phe Ser 
                405                 410                 415     


Val Pro Thr Gly Gln Pro Arg Pro Ser His His Gly Val Phe Ala Phe 
            420                 425                 430         


Leu Val Thr Pro Ser Pro Tyr Glu Leu Cys Ala Val Pro Arg 
        435                 440                 445     


<210>  6

<211>  490
<212>  PRT
<213>  Homo sapiens

<220>
<223>  P450 isozyme CYP2C19

<400>  6
Met Asp Pro Phe Val Val Leu Val Leu Cys Leu Ser Cys Leu Leu Leu 
1               5                   10                  15      


Leu Ser Ile Trp Arg Gln Ser Ser Gly Arg Gly Lys Leu Pro Pro Gly 
            20                  25                  30          


Pro Thr Pro Leu Pro Val Ile Gly Asn Ile Leu Gln Ile Asp Ile Lys 
        35                  40                  45              


Asp Val Ser Lys Ser Leu Thr Asn Leu Ser Lys Ile Tyr Gly Pro Val 
    50                  55                  60                  


Phe Thr Leu Tyr Phe Gly Leu Glu Arg Met Val Val Leu His Gly Tyr 
65                  70                  75                  80  


Glu Val Val Lys Glu Ala Leu Ile Asp Leu Gly Glu Glu Phe Ser Gly 
                85                  90                  95      


Arg Gly His Phe Pro Leu Ala Glu Arg Ala Asn Arg Gly Phe Gly Ile 
            100                 105                 110         


Val Phe Ser Asn Gly Lys Arg Trp Lys Glu Ile Arg Arg Phe Ser Leu 
        115                 120                 125             


Met Thr Leu Arg Asn Phe Gly Met Gly Lys Arg Ser Ile Glu Asp Arg 
    130                 135                 140                 


Val Gln Glu Glu Ala Arg Cys Leu Val Glu Glu Leu Arg Lys Thr Lys 
145                 150                 155                 160 


Ala Ser Pro Cys Asp Pro Thr Phe Ile Leu Gly Cys Ala Pro Cys Asn 
                165                 170                 175     


Val Ile Cys Ser Ile Ile Phe Gln Lys Arg Phe Asp Tyr Lys Asp Gln 
            180                 185                 190         


Gln Phe Leu Asn Leu Met Glu Lys Leu Asn Glu Asn Ile Arg Ile Val 
        195                 200                 205             


Ser Thr Pro Trp Ile Gln Ile Cys Asn Asn Phe Pro Thr Ile Ile Asp 
    210                 215                 220                 


Tyr Phe Pro Gly Thr His Asn Lys Leu Leu Lys Asn Leu Ala Phe Met 
225                 230                 235                 240 


Glu Ser Asp Ile Leu Glu Lys Val Lys Glu His Gln Glu Ser Met Asp 
                245                 250                 255     


Ile Asn Asn Pro Arg Asp Phe Ile Asp Cys Phe Leu Ile Lys Met Glu 
            260                 265                 270         


Lys Glu Lys Gln Asn Gln Gln Ser Glu Phe Thr Ile Glu Asn Leu Val 
        275                 280                 285             


Ile Thr Ala Ala Asp Leu Leu Gly Ala Gly Thr Glu Thr Thr Ser Thr 
    290                 295                 300                 


Thr Leu Arg Tyr Ala Leu Leu Leu Leu Leu Lys His Pro Glu Val Thr 
305                 310                 315                 320 


Ala Lys Val Gln Glu Glu Ile Glu Arg Val Ile Gly Arg Asn Arg Ser 
                325                 330                 335     


Pro Cys Met Gln Asp Arg Gly His Met Pro Tyr Thr Asp Ala Val Val 
            340                 345                 350         


His Glu Val Gln Arg Tyr Ile Asp Leu Ile Pro Thr Ser Leu Pro His 
        355                 360                 365             


Ala Val Thr Cys Asp Val Lys Phe Arg Asn Tyr Leu Ile Pro Lys Gly 
    370                 375                 380                 


Thr Thr Ile Leu Thr Ser Leu Thr Ser Val Leu His Asp Asn Lys Glu 
385                 390                 395                 400 


Phe Pro Asn Pro Glu Met Phe Asp Pro Arg His Phe Leu Asp Glu Gly 
                405                 410                 415     


Gly Asn Phe Lys Lys Ser Asn Tyr Phe Met Pro Phe Ser Ala Gly Lys 
            420                 425                 430         


Arg Ile Cys Val Gly Glu Gly Leu Ala Arg Met Glu Leu Phe Leu Phe 
        435                 440                 445             


Leu Thr Phe Ile Leu Gln Asn Phe Asn Leu Lys Ser Leu Ile Asp Pro 
    450                 455                 460                 


Lys Asp Leu Asp Thr Thr Pro Val Val Asn Gly Phe Ala Ser Val Pro 
465                 470                 475                 480 


Pro Phe Tyr Gln Leu Cys Phe Ile Pro Val 
                485                 490 


<210>  7

<211>  516
<212>  PRT
<213>  Homo sapiens

<220>
<223>  P450 isozyme CYP1A2

<400>  7
Met Ala Leu Ser Gln Ser Val Pro Phe Ser Ala Thr Glu Leu Leu Leu 
1               5                   10                  15      


Ala Ser Ala Ile Phe Cys Leu Val Phe Trp Val Leu Lys Gly Leu Arg 
            20                  25                  30          


Pro Arg Val Pro Lys Gly Leu Lys Ser Pro Pro Glu Pro Trp Gly Trp 
        35                  40                  45              


Pro Leu Leu Gly His Val Leu Thr Leu Gly Lys Asn Pro His Leu Ala 
    50                  55                  60                  


Leu Ser Arg Met Ser Gln Arg Tyr Gly Asp Val Leu Gln Ile Arg Ile 
65                  70                  75                  80  


Gly Ser Thr Pro Val Leu Val Leu Ser Arg Leu Asp Thr Ile Arg Gln 
                85                  90                  95      


Ala Leu Val Arg Gln Gly Asp Asp Phe Lys Gly Arg Pro Asp Leu Tyr 
            100                 105                 110         


Thr Ser Thr Leu Ile Thr Asp Gly Gln Ser Leu Thr Phe Ser Thr Asp 
        115                 120                 125             


Ser Gly Pro Val Trp Ala Ala Arg Arg Arg Leu Ala Gln Asn Ala Leu 
    130                 135                 140                 


Asn Thr Phe Ser Ile Ala Ser Asp Pro Ala Ser Ser Ser Ser Cys Tyr 
145                 150                 155                 160 


Leu Glu Glu His Val Ser Lys Glu Ala Lys Ala Leu Ile Ser Arg Leu 
                165                 170                 175     


Gln Glu Leu Met Ala Gly Pro Gly His Phe Asp Pro Tyr Asn Gln Val 
            180                 185                 190         


Val Val Ser Val Ala Asn Val Ile Gly Ala Met Cys Phe Gly Gln His 
        195                 200                 205             


Phe Pro Glu Ser Ser Asp Glu Met Leu Ser Leu Val Lys Asn Thr His 
    210                 215                 220                 


Glu Phe Val Glu Thr Ala Ser Ser Gly Asn Pro Leu Asp Phe Phe Pro 
225                 230                 235                 240 


Ile Leu Arg Tyr Leu Pro Asn Pro Ala Leu Gln Arg Phe Lys Ala Phe 
                245                 250                 255     


Asn Gln Arg Phe Leu Trp Phe Leu Gln Lys Thr Val Gln Glu His Tyr 
            260                 265                 270         


Gln Asp Phe Asp Lys Asn Ser Val Arg Asp Ile Thr Gly Ala Leu Phe 
        275                 280                 285             


Lys His Ser Lys Lys Gly Pro Arg Ala Ser Gly Asn Leu Ile Pro Gln 
    290                 295                 300                 


Glu Lys Ile Val Asn Leu Val Asn Asp Ile Phe Gly Ala Gly Phe Asp 
305                 310                 315                 320 


Thr Val Thr Thr Ala Ile Ser Trp Ser Leu Met Tyr Leu Val Thr Lys 
                325                 330                 335     


Pro Glu Ile Gln Arg Lys Ile Gln Lys Glu Leu Asp Thr Val Ile Gly 
            340                 345                 350         


Arg Glu Arg Arg Pro Arg Leu Ser Asp Arg Pro Gln Leu Pro Tyr Leu 
        355                 360                 365             


Glu Ala Phe Ile Leu Glu Thr Phe Arg His Ser Ser Phe Leu Pro Phe 
    370                 375                 380                 


Thr Ile Pro His Ser Thr Thr Arg Asp Thr Thr Leu Asn Gly Phe Tyr 
385                 390                 395                 400 


Ile Pro Lys Lys Cys Cys Val Phe Val Asn Gln Trp Gln Val Asn His 
                405                 410                 415     


Asp Pro Glu Leu Trp Glu Asp Pro Ser Glu Phe Arg Pro Glu Arg Phe 
            420                 425                 430         


Leu Thr Ala Asp Gly Thr Ala Ile Asn Lys Pro Leu Ser Glu Lys Met 
        435                 440                 445             


Met Leu Phe Gly Met Gly Lys Arg Arg Cys Ile Gly Glu Val Leu Ala 
    450                 455                 460                 


Lys Trp Glu Ile Phe Leu Phe Leu Ala Ile Leu Leu Gln Gln Leu Glu 
465                 470                 475                 480 


Phe Ser Val Pro Pro Gly Val Lys Val Asp Leu Thr Pro Ile Tyr Gly 
                485                 490                 495     


Leu Thr Met Lys His Ala Arg Cys Glu His Val Gln Ala Arg Leu Arg 
            500                 505                 510         


Phe Ser Ile Asn 
        515     


<210>  8

<211>  491
<212>  PRT
<213>  Homo sapiens

<220>
<223>  P450 isozyme CYP2B6

<400>  8
Met Glu Leu Ser Val Leu Leu Phe Leu Ala Leu Leu Thr Gly Leu Leu 
1               5                   10                  15      


Leu Leu Leu Val Gln Arg His Pro Asn Thr His Asp Arg Leu Pro Pro 
            20                  25                  30          


Gly Pro Arg Pro Leu Pro Leu Leu Gly Asn Leu Leu Gln Met Asp Arg 
        35                  40                  45              


Arg Gly Leu Leu Lys Ser Phe Leu Arg Phe Arg Glu Lys Tyr Gly Asp 
    50                  55                  60                  


Val Phe Thr Val His Leu Gly Pro Arg Pro Val Val Met Leu Cys Gly 
65                  70                  75                  80  


Val Glu Ala Ile Arg Glu Ala Leu Val Asp Lys Ala Glu Ala Phe Ser 
                85                  90                  95      


Gly Arg Gly Lys Ile Ala Met Val Asp Pro Phe Phe Arg Gly Tyr Gly 
            100                 105                 110         


Val Ile Phe Ala Asn Gly Asn Arg Trp Lys Val Leu Arg Arg Phe Ser 
        115                 120                 125             


Val Thr Thr Met Arg Asp Phe Gly Met Gly Lys Arg Ser Val Glu Glu 
    130                 135                 140                 


Arg Ile Gln Glu Glu Ala Gln Cys Leu Ile Glu Glu Leu Arg Lys Ser 
145                 150                 155                 160 


Lys Gly Ala Leu Met Asp Pro Thr Phe Leu Phe Gln Ser Ile Thr Ala 
                165                 170                 175     


Asn Ile Ile Cys Ser Ile Val Phe Gly Lys Arg Phe His Tyr Gln Asp 
            180                 185                 190         


Gln Glu Phe Leu Lys Met Leu Asn Leu Phe Tyr Gln Thr Phe Ser Leu 
        195                 200                 205             


Ile Ser Ser Val Phe Gly Gln Leu Phe Glu Leu Phe Ser Gly Phe Leu 
    210                 215                 220                 


Lys Tyr Phe Pro Gly Ala His Arg Gln Val Tyr Lys Asn Leu Gln Glu 
225                 230                 235                 240 


Ile Asn Ala Tyr Ile Gly His Ser Val Glu Lys His Arg Glu Thr Leu 
                245                 250                 255     


Asp Pro Ser Ala Pro Lys Asp Leu Ile Asp Thr Tyr Leu Leu His Met 
            260                 265                 270         


Glu Lys Glu Lys Ser Asn Ala His Ser Glu Phe Ser His Gln Asn Leu 
        275                 280                 285             


Asn Leu Asn Thr Leu Ser Leu Phe Phe Ala Gly Thr Glu Thr Thr Ser 
    290                 295                 300                 


Thr Thr Leu Arg Tyr Gly Phe Leu Leu Met Leu Lys Tyr Pro His Val 
305                 310                 315                 320 


Ala Glu Arg Val Tyr Arg Glu Ile Glu Gln Val Ile Gly Pro His Arg 
                325                 330                 335     


Pro Pro Glu Leu His Asp Arg Ala Lys Met Pro Tyr Thr Glu Ala Val 
            340                 345                 350         


Ile Tyr Glu Ile Gln Arg Phe Ser Asp Leu Leu Pro Met Gly Val Pro 
        355                 360                 365             


His Ile Val Thr Gln His Thr Ser Phe Arg Gly Tyr Ile Ile Pro Lys 
    370                 375                 380                 


Asp Thr Glu Val Phe Leu Ile Leu Ser Thr Ala Leu His Asp Pro His 
385                 390                 395                 400 


Tyr Phe Glu Lys Pro Asp Ala Phe Asn Pro Asp His Phe Leu Asp Ala 
                405                 410                 415     


Asn Gly Ala Leu Lys Lys Thr Glu Ala Phe Ile Pro Phe Ser Leu Gly 
            420                 425                 430         


Lys Arg Ile Cys Leu Gly Glu Gly Ile Ala Arg Ala Glu Leu Phe Leu 
        435                 440                 445             


Phe Phe Thr Thr Ile Leu Gln Asn Phe Ser Met Ala Ser Pro Val Ala 
    450                 455                 460                 


Pro Glu Asp Ile Asp Leu Thr Pro Gln Glu Cys Gly Val Gly Lys Ile 
465                 470                 475                 480 


Pro Pro Thr Tyr Gln Ile Arg Phe Leu Pro Arg 
                485                 490     


<210>  9

<211>  401
<212>  PRT
<213>  artificial sequence

<220>
<223>  cytidine deaminase (CDA)-BFP ORF

<400>  9
Met Ala Gln Lys Arg Pro Ala Cys Thr Leu Lys Pro Glu Cys Val Gln 
1               5                   10                  15      


Gln Leu Leu Val Cys Ser Gln Glu Ala Lys Lys Ser Ala Tyr Cys Pro 
            20                  25                  30          


Tyr Ser His Phe Pro Val Gly Ala Ala Leu Leu Thr Gln Glu Gly Arg 
        35                  40                  45              


Ile Phe Lys Gly Cys Asn Ile Glu Asn Ala Cys Tyr Pro Leu Gly Ile 
    50                  55                  60                  


Cys Ala Glu Arg Thr Ala Ile Gln Lys Ala Val Ser Glu Gly Tyr Lys 
65                  70                  75                  80  


Asp Phe Arg Ala Ile Ala Ile Ala Ser Asp Met Gln Asp Asp Phe Ile 
                85                  90                  95      


Ser Pro Cys Gly Ala Cys Arg Gln Val Met Arg Glu Phe Gly Thr Asn 
            100                 105                 110         


Trp Pro Val Tyr Met Thr Lys Pro Asp Gly Thr Tyr Ile Val Met Thr 
        115                 120                 125             


Val Gln Glu Leu Leu Pro Ser Ser Phe Gly Pro Glu Asp Leu Gln Lys 
    130                 135                 140                 


Thr Gln Gly Ser Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val 
145                 150                 155                 160 


Glu Glu Asn Pro Gly Pro Ser Gly Ser Glu Leu Ile Lys Glu Asn Met 
                165                 170                 175     


His Met Lys Leu Tyr Met Glu Gly Thr Val Asp Asn His His Phe Lys 
            180                 185                 190         


Cys Thr Ser Glu Gly Glu Gly Lys Pro Tyr Glu Gly Thr Gln Thr Met 
        195                 200                 205             


Arg Ile Lys Val Val Glu Gly Gly Pro Leu Pro Phe Ala Phe Asp Ile 
    210                 215                 220                 


Leu Ala Thr Ser Phe Leu Tyr Gly Ser Lys Thr Phe Ile Asn His Thr 
225                 230                 235                 240 


Gln Gly Ile Pro Asp Phe Phe Lys Gln Ser Phe Pro Glu Gly Phe Thr 
                245                 250                 255     


Trp Glu Arg Val Thr Thr Tyr Glu Asp Gly Gly Val Leu Thr Ala Thr 
            260                 265                 270         


Gln Asp Thr Ser Leu Gln Asp Gly Cys Leu Ile Tyr Asn Val Lys Ile 
        275                 280                 285             


Arg Gly Val Asn Phe Thr Ser Asn Gly Pro Val Met Gln Lys Lys Thr 
    290                 295                 300                 


Leu Gly Trp Glu Ala Phe Thr Glu Thr Leu Tyr Pro Ala Asp Gly Gly 
305                 310                 315                 320 


Leu Glu Gly Arg Asn Asp Met Ala Leu Lys Leu Val Gly Gly Ser His 
                325                 330                 335     


Leu Ile Ala Asn Ile Lys Thr Thr Tyr Arg Ser Lys Lys Pro Ala Lys 
            340                 345                 350         


Asn Leu Lys Met Pro Gly Val Tyr Tyr Val Asp Tyr Arg Leu Glu Arg 
        355                 360                 365             


Ile Lys Glu Ala Asn Asn Glu Thr Tyr Val Glu Gln His Glu Val Ala 
    370                 375                 380                 


Val Ala Arg Tyr Cys Asp Leu Pro Ser Lys Leu Gly His Lys Leu Asn 
385                 390                 395                 400 


Glu 
    


<210>  10

<211>  752
<212>  PRT
<213>  artificial sequence

<220>
<223>  CYP2D6_2-BFP ORF

<400>  10
Met Gly Leu Glu Ala Leu Val Pro Leu Ala Val Ile Val Ala Ile Phe 
1               5                   10                  15      


Leu Leu Leu Val Asp Leu Met His Arg Arg Gln Arg Trp Ala Ala Arg 
            20                  25                  30          


Tyr Pro Pro Gly Pro Leu Pro Leu Pro Gly Leu Gly Asn Leu Leu His 
        35                  40                  45              


Val Asp Phe Gln Asn Thr Pro Tyr Cys Phe Asp Gln Leu Arg Arg Arg 
    50                  55                  60                  


Phe Gly Asp Val Phe Ser Leu Gln Leu Ala Trp Thr Pro Val Val Val 
65                  70                  75                  80  


Leu Asn Gly Leu Ala Ala Val Arg Glu Ala Leu Val Thr His Gly Glu 
                85                  90                  95      


Asp Thr Ala Asp Arg Pro Pro Val Pro Ile Thr Gln Ile Leu Gly Phe 
            100                 105                 110         


Gly Pro Arg Ser Gln Gly Val Phe Leu Ala Arg Tyr Gly Pro Ala Trp 
        115                 120                 125             


Arg Glu Gln Arg Arg Phe Ser Val Ser Thr Leu Arg Asn Leu Gly Leu 
    130                 135                 140                 


Gly Lys Lys Ser Leu Glu Gln Trp Val Thr Glu Glu Ala Ala Cys Leu 
145                 150                 155                 160 


Cys Ala Ala Phe Ala Asn His Ser Gly Arg Pro Phe Arg Pro Asn Gly 
                165                 170                 175     


Leu Leu Asp Lys Ala Val Ser Asn Val Ile Ala Ser Leu Thr Cys Gly 
            180                 185                 190         


Arg Arg Phe Glu Tyr Asp Asp Pro Arg Phe Leu Arg Leu Leu Asp Leu 
        195                 200                 205             


Ala Gln Glu Gly Leu Lys Glu Glu Ser Gly Phe Leu Arg Glu Val Leu 
    210                 215                 220                 


Asn Ala Val Pro Val Leu Leu His Ile Pro Ala Leu Ala Gly Lys Val 
225                 230                 235                 240 


Leu Arg Phe Gln Lys Ala Phe Leu Thr Gln Leu Asp Glu Leu Leu Thr 
                245                 250                 255     


Glu His Arg Met Thr Trp Asp Pro Ala Gln Pro Pro Arg Asp Leu Thr 
            260                 265                 270         


Glu Ala Phe Leu Ala Glu Met Glu Lys Ala Lys Gly Asn Pro Glu Ser 
        275                 280                 285             


Ser Phe Asn Asp Glu Asn Leu Cys Ile Val Val Ala Asp Leu Phe Ser 
    290                 295                 300                 


Ala Gly Met Val Thr Thr Ser Thr Thr Leu Ala Trp Gly Leu Leu Leu 
305                 310                 315                 320 


Met Ile Leu His Pro Asp Val Gln Arg Arg Val Gln Gln Glu Ile Asp 
                325                 330                 335     


Asp Val Ile Gly Gln Val Arg Arg Pro Glu Met Gly Asp Gln Ala His 
            340                 345                 350         


Met Pro Tyr Thr Thr Ala Val Ile His Glu Val Gln Arg Phe Gly Asp 
        355                 360                 365             


Ile Val Pro Leu Gly Val Thr His Met Thr Ser Arg Asp Ile Glu Val 
    370                 375                 380                 


Gln Gly Phe Arg Ile Pro Lys Gly Thr Thr Leu Ile Thr Asn Leu Ser 
385                 390                 395                 400 


Ser Val Leu Lys Asp Glu Ala Val Trp Glu Lys Pro Phe Arg Phe His 
                405                 410                 415     


Pro Glu His Phe Leu Asp Ala Gln Gly His Phe Val Lys Pro Glu Ala 
            420                 425                 430         


Phe Leu Pro Phe Ser Ala Gly Arg Arg Ala Cys Leu Gly Glu Pro Leu 
        435                 440                 445             


Ala Arg Met Glu Leu Phe Leu Phe Phe Thr Ser Leu Leu Gln His Phe 
    450                 455                 460                 


Ser Phe Ser Val Pro Thr Gly Gln Pro Arg Pro Ser His His Gly Val 
465                 470                 475                 480 


Phe Ala Phe Leu Val Thr Pro Ser Pro Tyr Glu Leu Cys Ala Val Pro 
                485                 490                 495     


Arg Gly Ser Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu 
            500                 505                 510         


Glu Asn Pro Gly Pro Ser Gly Ser Glu Leu Ile Lys Glu Asn Met His 
        515                 520                 525             


Met Lys Leu Tyr Met Glu Gly Thr Val Asp Asn His His Phe Lys Cys 
    530                 535                 540                 


Thr Ser Glu Gly Glu Gly Lys Pro Tyr Glu Gly Thr Gln Thr Met Arg 
545                 550                 555                 560 


Ile Lys Val Val Glu Gly Gly Pro Leu Pro Phe Ala Phe Asp Ile Leu 
                565                 570                 575     


Ala Thr Ser Phe Leu Tyr Gly Ser Lys Thr Phe Ile Asn His Thr Gln 
            580                 585                 590         


Gly Ile Pro Asp Phe Phe Lys Gln Ser Phe Pro Glu Gly Phe Thr Trp 
        595                 600                 605             


Glu Arg Val Thr Thr Tyr Glu Asp Gly Gly Val Leu Thr Ala Thr Gln 
    610                 615                 620                 


Asp Thr Ser Leu Gln Asp Gly Cys Leu Ile Tyr Asn Val Lys Ile Arg 
625                 630                 635                 640 


Gly Val Asn Phe Thr Ser Asn Gly Pro Val Met Gln Lys Lys Thr Leu 
                645                 650                 655     


Gly Trp Glu Ala Phe Thr Glu Thr Leu Tyr Pro Ala Asp Gly Gly Leu 
            660                 665                 670         


Glu Gly Arg Asn Asp Met Ala Leu Lys Leu Val Gly Gly Ser His Leu 
        675                 680                 685             


Ile Ala Asn Ile Lys Thr Thr Tyr Arg Ser Lys Lys Pro Ala Lys Asn 
    690                 695                 700                 


Leu Lys Met Pro Gly Val Tyr Tyr Val Asp Tyr Arg Leu Glu Arg Ile 
705                 710                 715                 720 


Lys Glu Ala Asn Asn Glu Thr Tyr Val Glu Gln His Glu Val Ala Val 
                725                 730                 735     


Ala Arg Tyr Cys Asp Leu Pro Ser Lys Leu Gly His Lys Leu Asn Glu 
            740                 745                 750         


<210>  11

<211>  745
<212>  PRT
<213>  artificial sequence

<220>
<223>  CYP2C9-BFP ORF

<400>  11
Met Asp Ser Leu Val Val Leu Val Leu Cys Leu Ser Cys Leu Leu Leu 
1               5                   10                  15      


Leu Ser Leu Trp Arg Gln Ser Ser Gly Arg Gly Lys Leu Pro Pro Gly 
            20                  25                  30          


Pro Thr Pro Leu Pro Val Ile Gly Asn Ile Leu Gln Ile Gly Ile Lys 
        35                  40                  45              


Asp Ile Ser Lys Ser Leu Thr Asn Leu Ser Lys Val Tyr Gly Pro Val 
    50                  55                  60                  


Phe Thr Leu Tyr Phe Gly Leu Lys Pro Ile Val Val Leu His Gly Tyr 
65                  70                  75                  80  


Glu Ala Val Lys Glu Ala Leu Ile Asp Leu Gly Glu Glu Phe Ser Gly 
                85                  90                  95      


Arg Gly Ile Phe Pro Leu Ala Glu Arg Ala Asn Arg Gly Phe Gly Ile 
            100                 105                 110         


Val Phe Ser Asn Gly Lys Lys Trp Lys Glu Ile Arg Arg Phe Ser Leu 
        115                 120                 125             


Met Thr Leu Arg Asn Phe Gly Met Gly Lys Arg Ser Ile Glu Asp Arg 
    130                 135                 140                 


Val Gln Glu Glu Ala Arg Cys Leu Val Glu Glu Leu Arg Lys Thr Lys 
145                 150                 155                 160 


Ala Ser Pro Cys Asp Pro Thr Phe Ile Leu Gly Cys Ala Pro Cys Asn 
                165                 170                 175     


Val Ile Cys Ser Ile Ile Phe His Lys Arg Phe Asp Tyr Lys Asp Gln 
            180                 185                 190         


Gln Phe Leu Asn Leu Met Glu Lys Leu Asn Glu Asn Ile Lys Ile Leu 
        195                 200                 205             


Ser Ser Pro Trp Ile Gln Ile Cys Asn Asn Phe Ser Pro Ile Ile Asp 
    210                 215                 220                 


Tyr Phe Pro Gly Thr His Asn Lys Leu Leu Lys Asn Val Ala Phe Met 
225                 230                 235                 240 


Lys Ser Tyr Ile Leu Glu Lys Val Lys Glu His Gln Glu Ser Met Asp 
                245                 250                 255     


Met Asn Asn Pro Gln Asp Phe Ile Asp Cys Phe Leu Met Lys Met Glu 
            260                 265                 270         


Lys Glu Lys His Asn Gln Pro Ser Glu Phe Thr Ile Glu Ser Leu Glu 
        275                 280                 285             


Asn Thr Ala Val Asp Leu Phe Gly Ala Gly Thr Glu Thr Thr Ser Thr 
    290                 295                 300                 


Thr Leu Arg Tyr Ala Leu Leu Leu Leu Leu Lys His Pro Glu Val Thr 
305                 310                 315                 320 


Ala Lys Val Gln Glu Glu Ile Glu Arg Val Ile Gly Arg Asn Arg Ser 
                325                 330                 335     


Pro Cys Met Gln Asp Arg Ser His Met Pro Tyr Thr Asp Ala Val Val 
            340                 345                 350         


His Glu Val Gln Arg Tyr Ile Asp Leu Leu Pro Thr Ser Leu Pro His 
        355                 360                 365             


Ala Val Thr Cys Asp Ile Lys Phe Arg Asn Tyr Leu Ile Pro Lys Gly 
    370                 375                 380                 


Thr Thr Ile Leu Ile Ser Leu Thr Ser Val Leu His Asp Asn Lys Glu 
385                 390                 395                 400 


Phe Pro Asn Pro Glu Met Phe Asp Pro His His Phe Leu Asp Glu Gly 
                405                 410                 415     


Gly Asn Phe Lys Lys Ser Lys Tyr Phe Met Pro Phe Ser Ala Gly Lys 
            420                 425                 430         


Arg Ile Cys Val Gly Glu Ala Leu Ala Gly Met Glu Leu Phe Leu Phe 
        435                 440                 445             


Leu Thr Ser Ile Leu Gln Asn Phe Asn Leu Lys Ser Leu Val Asp Pro 
    450                 455                 460                 


Lys Asn Leu Asp Thr Thr Pro Val Val Asn Gly Phe Ala Ser Val Pro 
465                 470                 475                 480 


Pro Phe Tyr Gln Leu Cys Phe Ile Pro Val Gly Ser Glu Gly Arg Gly 
                485                 490                 495     


Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly Pro Ser Gly 
            500                 505                 510         


Ser Glu Leu Ile Lys Glu Asn Met His Met Lys Leu Tyr Met Glu Gly 
        515                 520                 525             


Thr Val Asp Asn His His Phe Lys Cys Thr Ser Glu Gly Glu Gly Lys 
    530                 535                 540                 


Pro Tyr Glu Gly Thr Gln Thr Met Arg Ile Lys Val Val Glu Gly Gly 
545                 550                 555                 560 


Pro Leu Pro Phe Ala Phe Asp Ile Leu Ala Thr Ser Phe Leu Tyr Gly 
                565                 570                 575     


Ser Lys Thr Phe Ile Asn His Thr Gln Gly Ile Pro Asp Phe Phe Lys 
            580                 585                 590         


Gln Ser Phe Pro Glu Gly Phe Thr Trp Glu Arg Val Thr Thr Tyr Glu 
        595                 600                 605             


Asp Gly Gly Val Leu Thr Ala Thr Gln Asp Thr Ser Leu Gln Asp Gly 
    610                 615                 620                 


Cys Leu Ile Tyr Asn Val Lys Ile Arg Gly Val Asn Phe Thr Ser Asn 
625                 630                 635                 640 


Gly Pro Val Met Gln Lys Lys Thr Leu Gly Trp Glu Ala Phe Thr Glu 
                645                 650                 655     


Thr Leu Tyr Pro Ala Asp Gly Gly Leu Glu Gly Arg Asn Asp Met Ala 
            660                 665                 670         


Leu Lys Leu Val Gly Gly Ser His Leu Ile Ala Asn Ile Lys Thr Thr 
        675                 680                 685             


Tyr Arg Ser Lys Lys Pro Ala Lys Asn Leu Lys Met Pro Gly Val Tyr 
    690                 695                 700                 


Tyr Val Asp Tyr Arg Leu Glu Arg Ile Lys Glu Ala Asn Asn Glu Thr 
705                 710                 715                 720 


Tyr Val Glu Gln His Glu Val Ala Val Ala Arg Tyr Cys Asp Leu Pro 
                725                 730                 735     


Ser Lys Leu Gly His Lys Leu Asn Glu 
            740                 745 


<210>  12

<211>  758
<212>  PRT
<213>  artificial sequence

<220>
<223>  CYP3A4-BFP ORF

<400>  12
Met Ala Leu Ile Pro Asp Leu Ala Met Glu Thr Trp Leu Leu Leu Ala 
1               5                   10                  15      


Val Ser Leu Val Leu Leu Tyr Leu Tyr Gly Thr His Ser His Gly Leu 
            20                  25                  30          


Phe Lys Lys Leu Gly Ile Pro Gly Pro Thr Pro Leu Pro Phe Leu Gly 
        35                  40                  45              


Asn Ile Leu Ser Tyr His Lys Gly Phe Cys Met Phe Asp Met Glu Cys 
    50                  55                  60                  


His Lys Lys Tyr Gly Lys Val Trp Gly Phe Tyr Asp Gly Gln Gln Pro 
65                  70                  75                  80  


Val Leu Ala Ile Thr Asp Pro Asp Met Ile Lys Thr Val Leu Val Lys 
                85                  90                  95      


Glu Cys Tyr Ser Val Phe Thr Asn Arg Arg Pro Phe Gly Pro Val Gly 
            100                 105                 110         


Phe Met Lys Ser Ala Ile Ser Ile Ala Glu Asp Glu Glu Trp Lys Arg 
        115                 120                 125             


Leu Arg Ser Leu Leu Ser Pro Thr Phe Thr Ser Gly Lys Leu Lys Glu 
    130                 135                 140                 


Met Val Pro Ile Ile Ala Gln Tyr Gly Asp Val Leu Val Arg Asn Leu 
145                 150                 155                 160 


Arg Arg Glu Ala Glu Thr Gly Lys Pro Val Thr Leu Lys Asp Val Phe 
                165                 170                 175     


Gly Ala Tyr Ser Met Asp Val Ile Thr Ser Thr Ser Phe Gly Val Asn 
            180                 185                 190         


Ile Asp Ser Leu Asn Asn Pro Gln Asp Pro Phe Val Glu Asn Thr Lys 
        195                 200                 205             


Lys Leu Leu Arg Phe Asp Phe Leu Asp Pro Phe Phe Leu Ser Ile Thr 
    210                 215                 220                 


Val Phe Pro Phe Leu Ile Pro Ile Leu Glu Val Leu Asn Ile Cys Val 
225                 230                 235                 240 


Phe Pro Arg Glu Val Thr Asn Phe Leu Arg Lys Ser Val Lys Arg Met 
                245                 250                 255     


Lys Glu Ser Arg Leu Glu Asp Thr Gln Lys His Arg Val Asp Phe Leu 
            260                 265                 270         


Gln Leu Met Ile Asp Ser Gln Asn Ser Lys Glu Thr Glu Ser His Lys 
        275                 280                 285             


Ala Leu Ser Asp Leu Glu Leu Val Ala Gln Ser Ile Ile Phe Ile Phe 
    290                 295                 300                 


Ala Gly Tyr Glu Thr Thr Ser Ser Val Leu Ser Phe Ile Met Tyr Glu 
305                 310                 315                 320 


Leu Ala Thr His Pro Asp Val Gln Gln Lys Leu Gln Glu Glu Ile Asp 
                325                 330                 335     


Ala Val Leu Pro Asn Lys Ala Pro Pro Thr Tyr Asp Thr Val Leu Gln 
            340                 345                 350         


Met Glu Tyr Leu Asp Met Val Val Asn Glu Thr Leu Arg Leu Phe Pro 
        355                 360                 365             


Ile Ala Met Arg Leu Glu Arg Val Cys Lys Lys Asp Val Glu Ile Asn 
    370                 375                 380                 


Gly Met Phe Ile Pro Lys Gly Val Val Val Met Ile Pro Ser Tyr Ala 
385                 390                 395                 400 


Leu His Arg Asp Pro Lys Tyr Trp Thr Glu Pro Glu Lys Phe Leu Pro 
                405                 410                 415     


Glu Arg Phe Ser Lys Lys Asn Lys Asp Asn Ile Asp Pro Tyr Ile Tyr 
            420                 425                 430         


Thr Pro Phe Gly Ser Gly Pro Arg Asn Cys Ile Gly Met Arg Phe Ala 
        435                 440                 445             


Leu Met Asn Met Lys Leu Ala Leu Ile Arg Val Leu Gln Asn Phe Ser 
    450                 455                 460                 


Phe Lys Pro Cys Lys Glu Thr Gln Ile Pro Leu Lys Leu Ser Leu Gly 
465                 470                 475                 480 


Gly Leu Leu Gln Pro Glu Lys Pro Val Val Leu Lys Val Glu Ser Arg 
                485                 490                 495     


Asp Gly Thr Val Ser Gly Ala Gly Ser Glu Gly Arg Gly Ser Leu Leu 
            500                 505                 510         


Thr Cys Gly Asp Val Glu Glu Asn Pro Gly Pro Ser Gly Ser Glu Leu 
        515                 520                 525             


Ile Lys Glu Asn Met His Met Lys Leu Tyr Met Glu Gly Thr Val Asp 
    530                 535                 540                 


Asn His His Phe Lys Cys Thr Ser Glu Gly Glu Gly Lys Pro Tyr Glu 
545                 550                 555                 560 


Gly Thr Gln Thr Met Arg Ile Lys Val Val Glu Gly Gly Pro Leu Pro 
                565                 570                 575     


Phe Ala Phe Asp Ile Leu Ala Thr Ser Phe Leu Tyr Gly Ser Lys Thr 
            580                 585                 590         


Phe Ile Asn His Thr Gln Gly Ile Pro Asp Phe Phe Lys Gln Ser Phe 
        595                 600                 605             


Pro Glu Gly Phe Thr Trp Glu Arg Val Thr Thr Tyr Glu Asp Gly Gly 
    610                 615                 620                 


Val Leu Thr Ala Thr Gln Asp Thr Ser Leu Gln Asp Gly Cys Leu Ile 
625                 630                 635                 640 


Tyr Asn Val Lys Ile Arg Gly Val Asn Phe Thr Ser Asn Gly Pro Val 
                645                 650                 655     


Met Gln Lys Lys Thr Leu Gly Trp Glu Ala Phe Thr Glu Thr Leu Tyr 
            660                 665                 670         


Pro Ala Asp Gly Gly Leu Glu Gly Arg Asn Asp Met Ala Leu Lys Leu 
        675                 680                 685             


Val Gly Gly Ser His Leu Ile Ala Asn Ile Lys Thr Thr Tyr Arg Ser 
    690                 695                 700                 


Lys Lys Pro Ala Lys Asn Leu Lys Met Pro Gly Val Tyr Tyr Val Asp 
705                 710                 715                 720 


Tyr Arg Leu Glu Arg Ile Lys Glu Ala Asn Asn Glu Thr Tyr Val Glu 
                725                 730                 735     


Gln His Glu Val Ala Val Ala Arg Tyr Cys Asp Leu Pro Ser Lys Leu 
            740                 745                 750         


Gly His Lys Leu Asn Glu 
        755             


<210>  13

<211>  701
<212>  PRT
<213>  artificial sequence

<220>
<223>  CYP2D6_1-BFP ORF

<400>  13
Met Gly Leu Glu Ala Leu Val Pro Leu Ala Val Ile Val Ala Ile Phe 
1               5                   10                  15      


Leu Leu Leu Val Asp Leu Met His Arg Arg Gln Arg Trp Ala Ala Arg 
            20                  25                  30          


Tyr Pro Pro Gly Pro Leu Pro Leu Pro Gly Leu Gly Asn Leu Leu His 
        35                  40                  45              


Val Asp Phe Gln Asn Thr Pro Tyr Cys Phe Asp Gln Leu Arg Arg Arg 
    50                  55                  60                  


Phe Gly Asp Val Phe Ser Leu Gln Leu Ala Trp Thr Pro Val Val Val 
65                  70                  75                  80  


Leu Asn Gly Leu Ala Ala Val Arg Glu Ala Leu Val Thr His Gly Glu 
                85                  90                  95      


Asp Thr Ala Asp Arg Pro Pro Val Pro Ile Thr Gln Ile Leu Gly Phe 
            100                 105                 110         


Gly Pro Arg Ser Gln Gly Arg Pro Phe Arg Pro Asn Gly Leu Leu Asp 
        115                 120                 125             


Lys Ala Val Ser Asn Val Ile Ala Ser Leu Thr Cys Gly Arg Arg Phe 
    130                 135                 140                 


Glu Tyr Asp Asp Pro Arg Phe Leu Arg Leu Leu Asp Leu Ala Gln Glu 
145                 150                 155                 160 


Gly Leu Lys Glu Glu Ser Gly Phe Leu Arg Glu Val Leu Asn Ala Val 
                165                 170                 175     


Pro Val Leu Leu His Ile Pro Ala Leu Ala Gly Lys Val Leu Arg Phe 
            180                 185                 190         


Gln Lys Ala Phe Leu Thr Gln Leu Asp Glu Leu Leu Thr Glu His Arg 
        195                 200                 205             


Met Thr Trp Asp Pro Ala Gln Pro Pro Arg Asp Leu Thr Glu Ala Phe 
    210                 215                 220                 


Leu Ala Glu Met Glu Lys Ala Lys Gly Asn Pro Glu Ser Ser Phe Asn 
225                 230                 235                 240 


Asp Glu Asn Leu Cys Ile Val Val Ala Asp Leu Phe Ser Ala Gly Met 
                245                 250                 255     


Val Thr Thr Ser Thr Thr Leu Ala Trp Gly Leu Leu Leu Met Ile Leu 
            260                 265                 270         


His Pro Asp Val Gln Arg Arg Val Gln Gln Glu Ile Asp Asp Val Ile 
        275                 280                 285             


Gly Gln Val Arg Arg Pro Glu Met Gly Asp Gln Ala His Met Pro Tyr 
    290                 295                 300                 


Thr Thr Ala Val Ile His Glu Val Gln Arg Phe Gly Asp Ile Val Pro 
305                 310                 315                 320 


Leu Gly Val Thr His Met Thr Ser Arg Asp Ile Glu Val Gln Gly Phe 
                325                 330                 335     


Arg Ile Pro Lys Gly Thr Thr Leu Ile Thr Asn Leu Ser Ser Val Leu 
            340                 345                 350         


Lys Asp Glu Ala Val Trp Glu Lys Pro Phe Arg Phe His Pro Glu His 
        355                 360                 365             


Phe Leu Asp Ala Gln Gly His Phe Val Lys Pro Glu Ala Phe Leu Pro 
    370                 375                 380                 


Phe Ser Ala Gly Arg Arg Ala Cys Leu Gly Glu Pro Leu Ala Arg Met 
385                 390                 395                 400 


Glu Leu Phe Leu Phe Phe Thr Ser Leu Leu Gln His Phe Ser Phe Ser 
                405                 410                 415     


Val Pro Thr Gly Gln Pro Arg Pro Ser His His Gly Val Phe Ala Phe 
            420                 425                 430         


Leu Val Thr Pro Ser Pro Tyr Glu Leu Cys Ala Val Pro Arg Gly Ser 
        435                 440                 445             


Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro 
    450                 455                 460                 


Gly Pro Ser Gly Ser Glu Leu Ile Lys Glu Asn Met His Met Lys Leu 
465                 470                 475                 480 


Tyr Met Glu Gly Thr Val Asp Asn His His Phe Lys Cys Thr Ser Glu 
                485                 490                 495     


Gly Glu Gly Lys Pro Tyr Glu Gly Thr Gln Thr Met Arg Ile Lys Val 
            500                 505                 510         


Val Glu Gly Gly Pro Leu Pro Phe Ala Phe Asp Ile Leu Ala Thr Ser 
        515                 520                 525             


Phe Leu Tyr Gly Ser Lys Thr Phe Ile Asn His Thr Gln Gly Ile Pro 
    530                 535                 540                 


Asp Phe Phe Lys Gln Ser Phe Pro Glu Gly Phe Thr Trp Glu Arg Val 
545                 550                 555                 560 


Thr Thr Tyr Glu Asp Gly Gly Val Leu Thr Ala Thr Gln Asp Thr Ser 
                565                 570                 575     


Leu Gln Asp Gly Cys Leu Ile Tyr Asn Val Lys Ile Arg Gly Val Asn 
            580                 585                 590         


Phe Thr Ser Asn Gly Pro Val Met Gln Lys Lys Thr Leu Gly Trp Glu 
        595                 600                 605             


Ala Phe Thr Glu Thr Leu Tyr Pro Ala Asp Gly Gly Leu Glu Gly Arg 
    610                 615                 620                 


Asn Asp Met Ala Leu Lys Leu Val Gly Gly Ser His Leu Ile Ala Asn 
625                 630                 635                 640 


Ile Lys Thr Thr Tyr Arg Ser Lys Lys Pro Ala Lys Asn Leu Lys Met 
                645                 650                 655     


Pro Gly Val Tyr Tyr Val Asp Tyr Arg Leu Glu Arg Ile Lys Glu Ala 
            660                 665                 670         


Asn Asn Glu Thr Tyr Val Glu Gln His Glu Val Ala Val Ala Arg Tyr 
        675                 680                 685             


Cys Asp Leu Pro Ser Lys Leu Gly His Lys Leu Asn Glu 
    690                 695                 700     


<210>  14

<211>  745
<212>  PRT
<213>  artificial sequence

<220>
<223>  CYP2C19-BFP ORF

<400>  14
Met Asp Pro Phe Val Val Leu Val Leu Cys Leu Ser Cys Leu Leu Leu 
1               5                   10                  15      


Leu Ser Ile Trp Arg Gln Ser Ser Gly Arg Gly Lys Leu Pro Pro Gly 
            20                  25                  30          


Pro Thr Pro Leu Pro Val Ile Gly Asn Ile Leu Gln Ile Asp Ile Lys 
        35                  40                  45              


Asp Val Ser Lys Ser Leu Thr Asn Leu Ser Lys Ile Tyr Gly Pro Val 
    50                  55                  60                  


Phe Thr Leu Tyr Phe Gly Leu Glu Arg Met Val Val Leu His Gly Tyr 
65                  70                  75                  80  


Glu Val Val Lys Glu Ala Leu Ile Asp Leu Gly Glu Glu Phe Ser Gly 
                85                  90                  95      


Arg Gly His Phe Pro Leu Ala Glu Arg Ala Asn Arg Gly Phe Gly Ile 
            100                 105                 110         


Val Phe Ser Asn Gly Lys Arg Trp Lys Glu Ile Arg Arg Phe Ser Leu 
        115                 120                 125             


Met Thr Leu Arg Asn Phe Gly Met Gly Lys Arg Ser Ile Glu Asp Arg 
    130                 135                 140                 


Val Gln Glu Glu Ala Arg Cys Leu Val Glu Glu Leu Arg Lys Thr Lys 
145                 150                 155                 160 


Ala Ser Pro Cys Asp Pro Thr Phe Ile Leu Gly Cys Ala Pro Cys Asn 
                165                 170                 175     


Val Ile Cys Ser Ile Ile Phe Gln Lys Arg Phe Asp Tyr Lys Asp Gln 
            180                 185                 190         


Gln Phe Leu Asn Leu Met Glu Lys Leu Asn Glu Asn Ile Arg Ile Val 
        195                 200                 205             


Ser Thr Pro Trp Ile Gln Ile Cys Asn Asn Phe Pro Thr Ile Ile Asp 
    210                 215                 220                 


Tyr Phe Pro Gly Thr His Asn Lys Leu Leu Lys Asn Leu Ala Phe Met 
225                 230                 235                 240 


Glu Ser Asp Ile Leu Glu Lys Val Lys Glu His Gln Glu Ser Met Asp 
                245                 250                 255     


Ile Asn Asn Pro Arg Asp Phe Ile Asp Cys Phe Leu Ile Lys Met Glu 
            260                 265                 270         


Lys Glu Lys Gln Asn Gln Gln Ser Glu Phe Thr Ile Glu Asn Leu Val 
        275                 280                 285             


Ile Thr Ala Ala Asp Leu Leu Gly Ala Gly Thr Glu Thr Thr Ser Thr 
    290                 295                 300                 


Thr Leu Arg Tyr Ala Leu Leu Leu Leu Leu Lys His Pro Glu Val Thr 
305                 310                 315                 320 


Ala Lys Val Gln Glu Glu Ile Glu Arg Val Ile Gly Arg Asn Arg Ser 
                325                 330                 335     


Pro Cys Met Gln Asp Arg Gly His Met Pro Tyr Thr Asp Ala Val Val 
            340                 345                 350         


His Glu Val Gln Arg Tyr Ile Asp Leu Ile Pro Thr Ser Leu Pro His 
        355                 360                 365             


Ala Val Thr Cys Asp Val Lys Phe Arg Asn Tyr Leu Ile Pro Lys Gly 
    370                 375                 380                 


Thr Thr Ile Leu Thr Ser Leu Thr Ser Val Leu His Asp Asn Lys Glu 
385                 390                 395                 400 


Phe Pro Asn Pro Glu Met Phe Asp Pro Arg His Phe Leu Asp Glu Gly 
                405                 410                 415     


Gly Asn Phe Lys Lys Ser Asn Tyr Phe Met Pro Phe Ser Ala Gly Lys 
            420                 425                 430         


Arg Ile Cys Val Gly Glu Gly Leu Ala Arg Met Glu Leu Phe Leu Phe 
        435                 440                 445             


Leu Thr Phe Ile Leu Gln Asn Phe Asn Leu Lys Ser Leu Ile Asp Pro 
    450                 455                 460                 


Lys Asp Leu Asp Thr Thr Pro Val Val Asn Gly Phe Ala Ser Val Pro 
465                 470                 475                 480 


Pro Phe Tyr Gln Leu Cys Phe Ile Pro Val Gly Ser Glu Gly Arg Gly 
                485                 490                 495     


Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly Pro Ser Gly 
            500                 505                 510         


Ser Glu Leu Ile Lys Glu Asn Met His Met Lys Leu Tyr Met Glu Gly 
        515                 520                 525             


Thr Val Asp Asn His His Phe Lys Cys Thr Ser Glu Gly Glu Gly Lys 
    530                 535                 540                 


Pro Tyr Glu Gly Thr Gln Thr Met Arg Ile Lys Val Val Glu Gly Gly 
545                 550                 555                 560 


Pro Leu Pro Phe Ala Phe Asp Ile Leu Ala Thr Ser Phe Leu Tyr Gly 
                565                 570                 575     


Ser Lys Thr Phe Ile Asn His Thr Gln Gly Ile Pro Asp Phe Phe Lys 
            580                 585                 590         


Gln Ser Phe Pro Glu Gly Phe Thr Trp Glu Arg Val Thr Thr Tyr Glu 
        595                 600                 605             


Asp Gly Gly Val Leu Thr Ala Thr Gln Asp Thr Ser Leu Gln Asp Gly 
    610                 615                 620                 


Cys Leu Ile Tyr Asn Val Lys Ile Arg Gly Val Asn Phe Thr Ser Asn 
625                 630                 635                 640 


Gly Pro Val Met Gln Lys Lys Thr Leu Gly Trp Glu Ala Phe Thr Glu 
                645                 650                 655     


Thr Leu Tyr Pro Ala Asp Gly Gly Leu Glu Gly Arg Asn Asp Met Ala 
            660                 665                 670         


Leu Lys Leu Val Gly Gly Ser His Leu Ile Ala Asn Ile Lys Thr Thr 
        675                 680                 685             


Tyr Arg Ser Lys Lys Pro Ala Lys Asn Leu Lys Met Pro Gly Val Tyr 
    690                 695                 700                 


Tyr Val Asp Tyr Arg Leu Glu Arg Ile Lys Glu Ala Asn Asn Glu Thr 
705                 710                 715                 720 


Tyr Val Glu Gln His Glu Val Ala Val Ala Arg Tyr Cys Asp Leu Pro 
                725                 730                 735     


Ser Lys Leu Gly His Lys Leu Asn Glu 
            740                 745 


<210>  15

<211>  771
<212>  PRT
<213>  artificial sequence

<220>
<223>  CYP1A2-BFP ORF

<400>  15
Met Ala Leu Ser Gln Ser Val Pro Phe Ser Ala Thr Glu Leu Leu Leu 
1               5                   10                  15      


Ala Ser Ala Ile Phe Cys Leu Val Phe Trp Val Leu Lys Gly Leu Arg 
            20                  25                  30          


Pro Arg Val Pro Lys Gly Leu Lys Ser Pro Pro Glu Pro Trp Gly Trp 
        35                  40                  45              


Pro Leu Leu Gly His Val Leu Thr Leu Gly Lys Asn Pro His Leu Ala 
    50                  55                  60                  


Leu Ser Arg Met Ser Gln Arg Tyr Gly Asp Val Leu Gln Ile Arg Ile 
65                  70                  75                  80  


Gly Ser Thr Pro Val Leu Val Leu Ser Arg Leu Asp Thr Ile Arg Gln 
                85                  90                  95      


Ala Leu Val Arg Gln Gly Asp Asp Phe Lys Gly Arg Pro Asp Leu Tyr 
            100                 105                 110         


Thr Ser Thr Leu Ile Thr Asp Gly Gln Ser Leu Thr Phe Ser Thr Asp 
        115                 120                 125             


Ser Gly Pro Val Trp Ala Ala Arg Arg Arg Leu Ala Gln Asn Ala Leu 
    130                 135                 140                 


Asn Thr Phe Ser Ile Ala Ser Asp Pro Ala Ser Ser Ser Ser Cys Tyr 
145                 150                 155                 160 


Leu Glu Glu His Val Ser Lys Glu Ala Lys Ala Leu Ile Ser Arg Leu 
                165                 170                 175     


Gln Glu Leu Met Ala Gly Pro Gly His Phe Asp Pro Tyr Asn Gln Val 
            180                 185                 190         


Val Val Ser Val Ala Asn Val Ile Gly Ala Met Cys Phe Gly Gln His 
        195                 200                 205             


Phe Pro Glu Ser Ser Asp Glu Met Leu Ser Leu Val Lys Asn Thr His 
    210                 215                 220                 


Glu Phe Val Glu Thr Ala Ser Ser Gly Asn Pro Leu Asp Phe Phe Pro 
225                 230                 235                 240 


Ile Leu Arg Tyr Leu Pro Asn Pro Ala Leu Gln Arg Phe Lys Ala Phe 
                245                 250                 255     


Asn Gln Arg Phe Leu Trp Phe Leu Gln Lys Thr Val Gln Glu His Tyr 
            260                 265                 270         


Gln Asp Phe Asp Lys Asn Ser Val Arg Asp Ile Thr Gly Ala Leu Phe 
        275                 280                 285             


Lys His Ser Lys Lys Gly Pro Arg Ala Ser Gly Asn Leu Ile Pro Gln 
    290                 295                 300                 


Glu Lys Ile Val Asn Leu Val Asn Asp Ile Phe Gly Ala Gly Phe Asp 
305                 310                 315                 320 


Thr Val Thr Thr Ala Ile Ser Trp Ser Leu Met Tyr Leu Val Thr Lys 
                325                 330                 335     


Pro Glu Ile Gln Arg Lys Ile Gln Lys Glu Leu Asp Thr Val Ile Gly 
            340                 345                 350         


Arg Glu Arg Arg Pro Arg Leu Ser Asp Arg Pro Gln Leu Pro Tyr Leu 
        355                 360                 365             


Glu Ala Phe Ile Leu Glu Thr Phe Arg His Ser Ser Phe Leu Pro Phe 
    370                 375                 380                 


Thr Ile Pro His Ser Thr Thr Arg Asp Thr Thr Leu Asn Gly Phe Tyr 
385                 390                 395                 400 


Ile Pro Lys Lys Cys Cys Val Phe Val Asn Gln Trp Gln Val Asn His 
                405                 410                 415     


Asp Pro Glu Leu Trp Glu Asp Pro Ser Glu Phe Arg Pro Glu Arg Phe 
            420                 425                 430         


Leu Thr Ala Asp Gly Thr Ala Ile Asn Lys Pro Leu Ser Glu Lys Met 
        435                 440                 445             


Met Leu Phe Gly Met Gly Lys Arg Arg Cys Ile Gly Glu Val Leu Ala 
    450                 455                 460                 


Lys Trp Glu Ile Phe Leu Phe Leu Ala Ile Leu Leu Gln Gln Leu Glu 
465                 470                 475                 480 


Phe Ser Val Pro Pro Gly Val Lys Val Asp Leu Thr Pro Ile Tyr Gly 
                485                 490                 495     


Leu Thr Met Lys His Ala Arg Cys Glu His Val Gln Ala Arg Leu Arg 
            500                 505                 510         


Phe Ser Ile Asn Gly Ser Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly 
        515                 520                 525             


Asp Val Glu Glu Asn Pro Gly Pro Ser Gly Ser Glu Leu Ile Lys Glu 
    530                 535                 540                 


Asn Met His Met Lys Leu Tyr Met Glu Gly Thr Val Asp Asn His His 
545                 550                 555                 560 


Phe Lys Cys Thr Ser Glu Gly Glu Gly Lys Pro Tyr Glu Gly Thr Gln 
                565                 570                 575     


Thr Met Arg Ile Lys Val Val Glu Gly Gly Pro Leu Pro Phe Ala Phe 
            580                 585                 590         


Asp Ile Leu Ala Thr Ser Phe Leu Tyr Gly Ser Lys Thr Phe Ile Asn 
        595                 600                 605             


His Thr Gln Gly Ile Pro Asp Phe Phe Lys Gln Ser Phe Pro Glu Gly 
    610                 615                 620                 


Phe Thr Trp Glu Arg Val Thr Thr Tyr Glu Asp Gly Gly Val Leu Thr 
625                 630                 635                 640 


Ala Thr Gln Asp Thr Ser Leu Gln Asp Gly Cys Leu Ile Tyr Asn Val 
                645                 650                 655     


Lys Ile Arg Gly Val Asn Phe Thr Ser Asn Gly Pro Val Met Gln Lys 
            660                 665                 670         


Lys Thr Leu Gly Trp Glu Ala Phe Thr Glu Thr Leu Tyr Pro Ala Asp 
        675                 680                 685             


Gly Gly Leu Glu Gly Arg Asn Asp Met Ala Leu Lys Leu Val Gly Gly 
    690                 695                 700                 


Ser His Leu Ile Ala Asn Ile Lys Thr Thr Tyr Arg Ser Lys Lys Pro 
705                 710                 715                 720 


Ala Lys Asn Leu Lys Met Pro Gly Val Tyr Tyr Val Asp Tyr Arg Leu 
                725                 730                 735     


Glu Arg Ile Lys Glu Ala Asn Asn Glu Thr Tyr Val Glu Gln His Glu 
            740                 745                 750         


Val Ala Val Ala Arg Tyr Cys Asp Leu Pro Ser Lys Leu Gly His Lys 
        755                 760                 765             


Leu Asn Glu 
    770     


<210>  16

<211>  746
<212>  PRT
<213>  artificial sequence

<220>
<223>  CYP2B6-BFP ORF

<400>  16
Met Glu Leu Ser Val Leu Leu Phe Leu Ala Leu Leu Thr Gly Leu Leu 
1               5                   10                  15      


Leu Leu Leu Val Gln Arg His Pro Asn Thr His Asp Arg Leu Pro Pro 
            20                  25                  30          


Gly Pro Arg Pro Leu Pro Leu Leu Gly Asn Leu Leu Gln Met Asp Arg 
        35                  40                  45              


Arg Gly Leu Leu Lys Ser Phe Leu Arg Phe Arg Glu Lys Tyr Gly Asp 
    50                  55                  60                  


Val Phe Thr Val His Leu Gly Pro Arg Pro Val Val Met Leu Cys Gly 
65                  70                  75                  80  


Val Glu Ala Ile Arg Glu Ala Leu Val Asp Lys Ala Glu Ala Phe Ser 
                85                  90                  95      


Gly Arg Gly Lys Ile Ala Met Val Asp Pro Phe Phe Arg Gly Tyr Gly 
            100                 105                 110         


Val Ile Phe Ala Asn Gly Asn Arg Trp Lys Val Leu Arg Arg Phe Ser 
        115                 120                 125             


Val Thr Thr Met Arg Asp Phe Gly Met Gly Lys Arg Ser Val Glu Glu 
    130                 135                 140                 


Arg Ile Gln Glu Glu Ala Gln Cys Leu Ile Glu Glu Leu Arg Lys Ser 
145                 150                 155                 160 


Lys Gly Ala Leu Met Asp Pro Thr Phe Leu Phe Gln Ser Ile Thr Ala 
                165                 170                 175     


Asn Ile Ile Cys Ser Ile Val Phe Gly Lys Arg Phe His Tyr Gln Asp 
            180                 185                 190         


Gln Glu Phe Leu Lys Met Leu Asn Leu Phe Tyr Gln Thr Phe Ser Leu 
        195                 200                 205             


Ile Ser Ser Val Phe Gly Gln Leu Phe Glu Leu Phe Ser Gly Phe Leu 
    210                 215                 220                 


Lys Tyr Phe Pro Gly Ala His Arg Gln Val Tyr Lys Asn Leu Gln Glu 
225                 230                 235                 240 


Ile Asn Ala Tyr Ile Gly His Ser Val Glu Lys His Arg Glu Thr Leu 
                245                 250                 255     


Asp Pro Ser Ala Pro Lys Asp Leu Ile Asp Thr Tyr Leu Leu His Met 
            260                 265                 270         


Glu Lys Glu Lys Ser Asn Ala His Ser Glu Phe Ser His Gln Asn Leu 
        275                 280                 285             


Asn Leu Asn Thr Leu Ser Leu Phe Phe Ala Gly Thr Glu Thr Thr Ser 
    290                 295                 300                 


Thr Thr Leu Arg Tyr Gly Phe Leu Leu Met Leu Lys Tyr Pro His Val 
305                 310                 315                 320 


Ala Glu Arg Val Tyr Arg Glu Ile Glu Gln Val Ile Gly Pro His Arg 
                325                 330                 335     


Pro Pro Glu Leu His Asp Arg Ala Lys Met Pro Tyr Thr Glu Ala Val 
            340                 345                 350         


Ile Tyr Glu Ile Gln Arg Phe Ser Asp Leu Leu Pro Met Gly Val Pro 
        355                 360                 365             


His Ile Val Thr Gln His Thr Ser Phe Arg Gly Tyr Ile Ile Pro Lys 
    370                 375                 380                 


Asp Thr Glu Val Phe Leu Ile Leu Ser Thr Ala Leu His Asp Pro His 
385                 390                 395                 400 


Tyr Phe Glu Lys Pro Asp Ala Phe Asn Pro Asp His Phe Leu Asp Ala 
                405                 410                 415     


Asn Gly Ala Leu Lys Lys Thr Glu Ala Phe Ile Pro Phe Ser Leu Gly 
            420                 425                 430         


Lys Arg Ile Cys Leu Gly Glu Gly Ile Ala Arg Ala Glu Leu Phe Leu 
        435                 440                 445             


Phe Phe Thr Thr Ile Leu Gln Asn Phe Ser Met Ala Ser Pro Val Ala 
    450                 455                 460                 


Pro Glu Asp Ile Asp Leu Thr Pro Gln Glu Cys Gly Val Gly Lys Ile 
465                 470                 475                 480 


Pro Pro Thr Tyr Gln Ile Arg Phe Leu Pro Arg Gly Ser Glu Gly Arg 
                485                 490                 495     


Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly Pro Ser 
            500                 505                 510         


Gly Ser Glu Leu Ile Lys Glu Asn Met His Met Lys Leu Tyr Met Glu 
        515                 520                 525             


Gly Thr Val Asp Asn His His Phe Lys Cys Thr Ser Glu Gly Glu Gly 
    530                 535                 540                 


Lys Pro Tyr Glu Gly Thr Gln Thr Met Arg Ile Lys Val Val Glu Gly 
545                 550                 555                 560 


Gly Pro Leu Pro Phe Ala Phe Asp Ile Leu Ala Thr Ser Phe Leu Tyr 
                565                 570                 575     


Gly Ser Lys Thr Phe Ile Asn His Thr Gln Gly Ile Pro Asp Phe Phe 
            580                 585                 590         


Lys Gln Ser Phe Pro Glu Gly Phe Thr Trp Glu Arg Val Thr Thr Tyr 
        595                 600                 605             


Glu Asp Gly Gly Val Leu Thr Ala Thr Gln Asp Thr Ser Leu Gln Asp 
    610                 615                 620                 


Gly Cys Leu Ile Tyr Asn Val Lys Ile Arg Gly Val Asn Phe Thr Ser 
625                 630                 635                 640 


Asn Gly Pro Val Met Gln Lys Lys Thr Leu Gly Trp Glu Ala Phe Thr 
                645                 650                 655     


Glu Thr Leu Tyr Pro Ala Asp Gly Gly Leu Glu Gly Arg Asn Asp Met 
            660                 665                 670         


Ala Leu Lys Leu Val Gly Gly Ser His Leu Ile Ala Asn Ile Lys Thr 
        675                 680                 685             


Thr Tyr Arg Ser Lys Lys Pro Ala Lys Asn Leu Lys Met Pro Gly Val 
    690                 695                 700                 


Tyr Tyr Val Asp Tyr Arg Leu Glu Arg Ile Lys Glu Ala Asn Asn Glu 
705                 710                 715                 720 


Thr Tyr Val Glu Gln His Glu Val Ala Val Ala Arg Tyr Cys Asp Leu 
                725                 730                 735     


Pro Ser Lys Leu Gly His Lys Leu Asn Glu 
            740                 745     


<210>  17

<211>  49
<212>  DNA
<213>  Homo sapiens

<220>
<223>  Target dCK2

<400>  17
tggttcctga acctgttgcc agatggtgca atgttcaaag tactcaaga                 49


<210>  18

<211>  2814
<212>  DNA
<213>  artificial sequence

<220>
<223>  TALEN dCK2 LEFT

<400>  18
atgggcgatc ctaaaaagaa acgtaaggtc atcgattacc catacgatgt tccagattac     60
gctatcgata tcgccgatct acgcacgctc ggctacagcc agcagcaaca ggagaagatc    120
aaaccgaagg ttcgttcgac agtggcgcag caccacgagg cactggtcgg ccacgggttt    180
acacacgcgc acatcgttgc gttaagccaa cacccggcag cgttagggac cgtcgctgtc    240
aagtatcagg acatgatcgc agcgttgcca gaggcgacac acgaagcgat cgttggcgtc    300
ggcaaacagt ggtccggcgc acgcgctctg gaggccttgc tcacggtggc gggagagttg    360
agaggtccac cgttacagtt ggacacaggc caacttctca agattgcaaa acgtggcggc    420
gtgaccgcag tggaggcagt gcatgcatgg cgcaatgcac tgacgggtgc cccgctcaac    480
ttgacccccc agcaggtggt ggccatcgcc agcaataatg gtggcaagca ggcgctggag    540
acggtccagc ggctgttgcc ggtgctgtgc caggcccacg gcttgacccc ccagcaggtg    600
gtggccatcg ccagcaataa tggtggcaag caggcgctgg agacggtcca gcggctgttg    660
ccggtgctgt gccaggccca cggcttgacc ccccagcagg tggtggccat cgccagcaat    720
ggcggtggca agcaggcgct ggagacggtc cagcggctgt tgccggtgct gtgccaggcc    780
cacggcttga ccccccagca ggtggtggcc atcgccagca atggcggtgg caagcaggcg    840
ctggagacgg tccagcggct gttgccggtg ctgtgccagg cccacggctt gaccccggag    900
caggtggtgg ccatcgccag ccacgatggc ggcaagcagg cgctggagac ggtccagcgg    960
ctgttgccgg tgctgtgcca ggcccacggc ttgaccccgg agcaggtggt ggccatcgcc   1020
agccacgatg gcggcaagca ggcgctggag acggtccagc ggctgttgcc ggtgctgtgc   1080
caggcccacg gcttgacccc ccagcaggtg gtggccatcg ccagcaatgg cggtggcaag   1140
caggcgctgg agacggtcca gcggctgttg ccggtgctgt gccaggccca cggcttgacc   1200
ccccagcagg tggtggccat cgccagcaat aatggtggca agcaggcgct ggagacggtc   1260
cagcggctgt tgccggtgct gtgccaggcc cacggcttga ccccggagca ggtggtggcc   1320
atcgccagca atattggtgg caagcaggcg ctggagacgg tgcaggcgct gttgccggtg   1380
ctgtgccagg cccacggctt gaccccggag caggtggtgg ccatcgccag caatattggt   1440
ggcaagcagg cgctggagac ggtgcaggcg ctgttgccgg tgctgtgcca ggcccacggc   1500
ttgaccccgg agcaggtggt ggccatcgcc agccacgatg gcggcaagca ggcgctggag   1560
acggtccagc ggctgttgcc ggtgctgtgc caggcccacg gcttgacccc ggagcaggtg   1620
gtggccatcg ccagccacga tggcggcaag caggcgctgg agacggtcca gcggctgttg   1680
ccggtgctgt gccaggccca cggcttgacc ccccagcagg tggtggccat cgccagcaat   1740
ggcggtggca agcaggcgct ggagacggtc cagcggctgt tgccggtgct gtgccaggcc   1800
cacggcttga ccccccagca ggtggtggcc atcgccagca ataatggtgg caagcaggcg   1860
ctggagacgg tccagcggct gttgccggtg ctgtgccagg cccacggctt gaccccccag   1920
caggtggtgg ccatcgccag caatggcggt ggcaagcagg cgctggagac ggtccagcgg   1980
ctgttgccgg tgctgtgcca ggcccacggc ttgacccctc agcaggtggt ggccatcgcc   2040
agcaatggcg gcggcaggcc ggcgctggag agcattgttg cccagttatc tcgccctgat   2100
ccggcgttgg ccgcgttgac caacgaccac ctcgtcgcct tggcctgcct cggcgggcgt   2160
cctgcgctgg atgcagtgaa aaagggattg ggggatccta tcagccgttc ccagctggtg   2220
aagtccgagc tggaggagaa gaaatccgag ttgaggcaca agctgaagta cgtgccccac   2280
gagtacatcg agctgatcga gatcgcccgg aacagcaccc aggaccgtat cctggagatg   2340
aaggtgatgg agttcttcat gaaggtgtac ggctacaggg gcaagcacct gggcggctcc   2400
aggaagcccg acggcgccat ctacaccgtg ggctccccca tcgactacgg cgtgatcgtg   2460
gacaccaagg cctactccgg cggctacaac ctgcccatcg gccaggccga cgaaatgcag   2520
aggtacgtgg aggagaacca gaccaggaac aagcacatca accccaacga gtggtggaag   2580
gtgtacccct ccagcgtgac cgagttcaag ttcctgttcg tgtccggcca cttcaagggc   2640
aactacaagg cccagctgac caggctgaac cacatcacca actgcaacgg cgccgtgctg   2700
tccgtggagg agctcctgat cggcggcgag atgatcaagg ccggcaccct gaccctggag   2760
gaggtgagga ggaagttcaa caacggcgag atcaacttcg cggccgactg ataa         2814


<210>  19

<211>  2814
<212>  DNA
<213>  artificial sequence

<220>
<223>  TALEN dCK2 RIGHT

<400>  19
atgggcgatc ctaaaaagaa acgtaaggtc atcgattacc catacgatgt tccagattac     60
gctatcgata tcgccgatct acgcacgctc ggctacagcc agcagcaaca ggagaagatc    120
aaaccgaagg ttcgttcgac agtggcgcag caccacgagg cactggtcgg ccacgggttt    180
acacacgcgc acatcgttgc gttaagccaa cacccggcag cgttagggac cgtcgctgtc    240
aagtatcagg acatgatcgc agcgttgcca gaggcgacac acgaagcgat cgttggcgtc    300
ggcaaacagt ggtccggcgc acgcgctctg gaggccttgc tcacggtggc gggagagttg    360
agaggtccac cgttacagtt ggacacaggc caacttctca agattgcaaa acgtggcggc    420
gtgaccgcag tggaggcagt gcatgcatgg cgcaatgcac tgacgggtgc cccgctcaac    480
ttgaccccgg agcaggtggt ggccatcgcc agccacgatg gcggcaagca ggcgctggag    540
acggtccagc ggctgttgcc ggtgctgtgc caggcccacg gcttgacccc ccagcaggtg    600
gtggccatcg ccagcaatgg cggtggcaag caggcgctgg agacggtcca gcggctgttg    660
ccggtgctgt gccaggccca cggcttgacc ccccagcagg tggtggccat cgccagcaat    720
ggcggtggca agcaggcgct ggagacggtc cagcggctgt tgccggtgct gtgccaggcc    780
cacggcttga ccccccagca ggtggtggcc atcgccagca ataatggtgg caagcaggcg    840
ctggagacgg tccagcggct gttgccggtg ctgtgccagg cccacggctt gaccccggag    900
caggtggtgg ccatcgccag caatattggt ggcaagcagg cgctggagac ggtgcaggcg    960
ctgttgccgg tgctgtgcca ggcccacggc ttgacccccc agcaggtggt ggccatcgcc   1020
agcaataatg gtggcaagca ggcgctggag acggtccagc ggctgttgcc ggtgctgtgc   1080
caggcccacg gcttgacccc ccagcaggtg gtggccatcg ccagcaatgg cggtggcaag   1140
caggcgctgg agacggtcca gcggctgttg ccggtgctgt gccaggccca cggcttgacc   1200
ccggagcagg tggtggccat cgccagcaat attggtggca agcaggcgct ggagacggtg   1260
caggcgctgt tgccggtgct gtgccaggcc cacggcttga ccccggagca ggtggtggcc   1320
atcgccagcc acgatggcgg caagcaggcg ctggagacgg tccagcggct gttgccggtg   1380
ctgtgccagg cccacggctt gaccccccag caggtggtgg ccatcgccag caatggcggt   1440
ggcaagcagg cgctggagac ggtccagcgg ctgttgccgg tgctgtgcca ggcccacggc   1500
ttgacccccc agcaggtggt ggccatcgcc agcaatggcg gtggcaagca ggcgctggag   1560
acggtccagc ggctgttgcc ggtgctgtgc caggcccacg gcttgacccc ccagcaggtg   1620
gtggccatcg ccagcaatgg cggtggcaag caggcgctgg agacggtcca gcggctgttg   1680
ccggtgctgt gccaggccca cggcttgacc ccccagcagg tggtggccat cgccagcaat   1740
aatggtggca agcaggcgct ggagacggtc cagcggctgt tgccggtgct gtgccaggcc   1800
cacggcttga ccccggagca ggtggtggcc atcgccagca atattggtgg caagcaggcg   1860
ctggagacgg tgcaggcgct gttgccggtg ctgtgccagg cccacggctt gaccccggag   1920
caggtggtgg ccatcgccag caatattggt ggcaagcagg cgctggagac ggtgcaggcg   1980
ctgttgccgg tgctgtgcca ggcccacggc ttgacccctc agcaggtggt ggccatcgcc   2040
agcaatggcg gcggcaggcc ggcgctggag agcattgttg cccagttatc tcgccctgat   2100
ccggcgttgg ccgcgttgac caacgaccac ctcgtcgcct tggcctgcct cggcgggcgt   2160
cctgcgctgg atgcagtgaa aaagggattg ggggatccta tcagccgttc ccagctggtg   2220
aagtccgagc tggaggagaa gaaatccgag ttgaggcaca agctgaagta cgtgccccac   2280
gagtacatcg agctgatcga gatcgcccgg aacagcaccc aggaccgtat cctggagatg   2340
aaggtgatgg agttcttcat gaaggtgtac ggctacaggg gcaagcacct gggcggctcc   2400
aggaagcccg acggcgccat ctacaccgtg ggctccccca tcgactacgg cgtgatcgtg   2460
gacaccaagg cctactccgg cggctacaac ctgcccatcg gccaggccga cgaaatgcag   2520
aggtacgtgg aggagaacca gaccaggaac aagcacatca accccaacga gtggtggaag   2580
gtgtacccct ccagcgtgac cgagttcaag ttcctgttcg tgtccggcca cttcaagggc   2640
aactacaagg cccagctgac caggctgaac cacatcacca actgcaacgg cgccgtgctg   2700
tccgtggagg agctcctgat cggcggcgag atgatcaagg ccggcaccct gaccctggag   2760
gaggtgagga ggaagttcaa caacggcgag atcaacttcg cggccgactg ataa         2814


<210>  20

<211>  957
<212>  DNA
<213>  Homo sapiens

<220>
<223>  cytidine deaminase (CDA)gene

<400>  20
caaaccatgg gaggctcctc tcctagaccc tgcatcctga aagctgcgta cctgagagcc     60
tgcggtctgg ctgcagggac acacccaagg ggaggagctg caatcgtgtc tggggcccca    120
gcccaggctg gccggagctc ctgtttcccg ctgctctgct gcctgcccgg ggtaccaaca    180
tggcccagaa gcgtcctgcc tgcaccctga agcctgagtg tgtccagcag ctgctggttt    240
gctcccagga ggccaagaag tcagcctact gcccctacag tcactttcct gtgggggctg    300
ccctgctcac ccaggagggg agaatcttca aagggtgcaa catagaaaat gcctgctacc    360
cgctgggcat ctgtgctgaa cggaccgcta tccagaaggc cgtctcagaa gggtacaagg    420
atttcagggc aattgctatc gccagtgaca tgcaagatga ttttatctct ccatgtgggg    480
cctgcaggca agtcatgaga gagtttggca ccaactggcc cgtgtacatg accaagccgg    540
atggtacgta tattgtcatg acggtccagg agctgctgcc ctcctccttt gggcctgagg    600
acctgcagaa gacccagtga cagccagaga atgcccactg cctgtaacag ccacctggag    660
aacttcataa agatgtctca cagccctggg gacacctgcc cagtgggccc cagccctaca    720
gggactgggc aaagatgatg tttccagatt acactccagc ctgagtcagc acccctccta    780
gcaacctgcc ttgggactta gaacaccgcc gccccctgcc ccacctttcc tttccttcct    840
gtgggccctc tttcaaagtc cagcctagtc tggactgctt ccccatcagc cttcccaagg    900
ttctatcctg ttccgagcaa cttttctaat tataaacatc acagaacatc ctggatc       957


<210>  21

<211>  957
<212>  DNA
<213>  Homo sapiens

<220>
<223>  CYP2D6 isoform 1 gene

<400>  21
caaaccatgg gaggctcctc tcctagaccc tgcatcctga aagctgcgta cctgagagcc     60
tgcggtctgg ctgcagggac acacccaagg ggaggagctg caatcgtgtc tggggcccca    120
gcccaggctg gccggagctc ctgtttcccg ctgctctgct gcctgcccgg ggtaccaaca    180
tggcccagaa gcgtcctgcc tgcaccctga agcctgagtg tgtccagcag ctgctggttt    240
gctcccagga ggccaagaag tcagcctact gcccctacag tcactttcct gtgggggctg    300
ccctgctcac ccaggagggg agaatcttca aagggtgcaa catagaaaat gcctgctacc    360
cgctgggcat ctgtgctgaa cggaccgcta tccagaaggc cgtctcagaa gggtacaagg    420
atttcagggc aattgctatc gccagtgaca tgcaagatga ttttatctct ccatgtgggg    480
cctgcaggca agtcatgaga gagtttggca ccaactggcc cgtgtacatg accaagccgg    540
atggtacgta tattgtcatg acggtccagg agctgctgcc ctcctccttt gggcctgagg    600
acctgcagaa gacccagtga cagccagaga atgcccactg cctgtaacag ccacctggag    660
aacttcataa agatgtctca cagccctggg gacacctgcc cagtgggccc cagccctaca    720
gggactgggc aaagatgatg tttccagatt acactccagc ctgagtcagc acccctccta    780
gcaacctgcc ttgggactta gaacaccgcc gccccctgcc ccacctttcc tttccttcct    840
gtgggccctc tttcaaagtc cagcctagtc tggactgctt ccccatcagc cttcccaagg    900
ttctatcctg ttccgagcaa cttttctaat tataaacatc acagaacatc ctggatc       957


<210>  22

<211>  1861
<212>  DNA
<213>  Homo sapiens

<220>
<223>  CYP2C9 gene

<400>  22
gtcttaacaa gaagagaagg cttcaatgga ttctcttgtg gtccttgtgc tctgtctctc     60
atgtttgctt ctcctttcac tctggagaca gagctctggg agaggaaaac tccctcctgg    120
ccccactcct ctcccagtga ttggaaatat cctacagata ggtattaagg acatcagcaa    180
atccttaacc aatctctcaa aggtctatgg ccctgtgttc actctgtatt ttggcctgaa    240
acccatagtg gtgctgcatg gatatgaagc agtgaaggaa gccctgattg atcttggaga    300
ggagttttct ggaagaggca ttttcccact ggctgaaaga gctaacagag gatttggaat    360
tgttttcagc aatggaaaga aatggaagga gatccggcgt ttctccctca tgacgctgcg    420
gaattttggg atggggaaga ggagcattga ggaccgtgtt caagaggaag cccgctgcct    480
tgtggaggag ttgagaaaaa ccaaggcctc accctgtgat cccactttca tcctgggctg    540
tgctccctgc aatgtgatct gctccattat tttccataaa cgttttgatt ataaagatca    600
gcaatttctt aacttaatgg aaaagttgaa tgaaaacatc aagattttga gcagcccctg    660
gatccagatc tgcaataatt tttctcctat cattgattac ttcccgggaa ctcacaacaa    720
attacttaaa aacgttgctt ttatgaaaag ttatattttg gaaaaagtaa aagaacacca    780
agaatcaatg gacatgaaca accctcagga ctttattgat tgcttcctga tgaaaatgga    840
gaaggaaaag cacaaccaac catctgaatt tactattgaa agcttggaaa acactgcagt    900
tgacttgttt ggagctggga cagagacgac aagcacaacc ctgagatatg ctctccttct    960
cctgctgaag cacccagagg tcacagctaa agtccaggaa gagattgaac gtgtgattgg   1020
cagaaaccgg agcccctgca tgcaagacag gagccacatg ccctacacag atgctgtggt   1080
gcacgaggtc cagagataca ttgaccttct ccccaccagc ctgccccatg cagtgacctg   1140
tgacattaaa ttcagaaact atctcattcc caagggcaca accatattaa tttccctgac   1200
ttctgtgcta catgacaaca aagaatttcc caacccagag atgtttgacc ctcatcactt   1260
tctggatgaa ggtggcaatt ttaagaaaag taaatacttc atgcctttct cagcaggaaa   1320
acggatttgt gtgggagaag ccctggccgg catggagctg tttttattcc tgacctccat   1380
tttacagaac tttaacctga aatctctggt tgacccaaag aaccttgaca ccactccagt   1440
tgtcaatgga tttgcctctg tgccgccctt ctaccagctg tgcttcattc ctgtctgaag   1500
aagagcagat ggcctggctg ctgctgtgca gtccctgcag ctctctttcc tctggggcat   1560
tatccatctt tcactatctg taatgccttt tctcacctgt catctcacat tttcccttcc   1620
ctgaagatct agtgaacatt cgacctccat tacggagagt ttcctatgtt tcactgtgca   1680
aatatatctg ctattctcca tactctgtaa cagttgcatt gactgtcaca taatgctcat   1740
acttatctaa tgttgagtta ttaatatgtt attattaaat agagaaatat gatttgtgta   1800
ttataattca aaggcatttc ttttctgcat gttctaaata aaaagcatta ttatttgctg   1860
a                                                                   1861


<210>  23

<211>  2792
<212>  DNA
<213>  Homo sapiens

<220>
<223>  CYP3A4 gene

<400>  23
aatcactgct gtgcagggca ggaaagctcc atgcacatag cccagcaaag agcaacacag     60
agctgaaagg aagactcaga ggagagagat aagtaaggaa agtagtgatg gctctcatcc    120
cagacttggc catggaaacc tggcttctcc tggctgtcag cctggtgctc ctctatctat    180
atggaaccca ttcacatgga ctttttaaga agcttggaat tccagggccc acacctctgc    240
cttttttggg aaatattttg tcctaccata agggcttttg tatgtttgac atggaatgtc    300
ataaaaagta tggaaaagtg tggggctttt atgatggtca acagcctgtg ctggctatca    360
cagatcctga catgatcaaa acagtgctag tgaaagaatg ttattctgtc ttcacaaacc    420
ggaggccttt tggtccagtg ggatttatga aaagtgccat ctctatagct gaggatgaag    480
aatggaagag attacgatca ttgctgtctc caaccttcac cagtggaaaa ctcaaggaga    540
tggtccctat cattgcccag tatggagatg tgttggtgag aaatctgagg cgggaagcag    600
agacaggcaa gcctgtcacc ttgaaagacg tctttggggc ctacagcatg gatgtgatca    660
ctagcacatc atttggagtg aacatcgact ctctcaacaa tccacaagac ccctttgtgg    720
aaaacaccaa gaagctttta agatttgatt ttttggatcc attctttctc tcaataacag    780
tctttccatt cctcatccca attcttgaag tattaaatat ctgtgtgttt ccaagagaag    840
ttacaaattt tttaagaaaa tctgtaaaaa ggatgaaaga aagtcgcctc gaagatacac    900
aaaagcaccg agtggatttc cttcagctga tgattgactc tcagaattca aaagaaactg    960
agtcccacaa agctctgtcc gatctggagc tcgtggccca atcaattatc tttatttttg   1020
ctggctatga aaccacgagc agtgttctct ccttcattat gtatgaactg gccactcacc   1080
ctgatgtcca gcagaaactg caggaggaaa ttgatgcagt tttacccaat aaggcaccac   1140
ccacctatga tactgtgcta cagatggagt atcttgacat ggtggtgaat gaaacgctca   1200
gattattccc aattgctatg agacttgaga gggtctgcaa aaaagatgtt gagatcaatg   1260
ggatgttcat tcccaaaggg gtggtggtga tgattccaag ctatgctctt caccgtgacc   1320
caaagtactg gacagagcct gagaagttcc tccctgaaag attcagcaag aagaacaagg   1380
acaacataga tccttacata tacacaccct ttggaagtgg acccagaaac tgcattggca   1440
tgaggtttgc tctcatgaac atgaaacttg ctctaatcag agtccttcag aacttctcct   1500
tcaaaccttg taaagaaaca cagatccccc tgaaattaag cttaggagga cttcttcaac   1560
cagaaaaacc cgttgttcta aaggttgagt caagggatgg caccgtaagt ggagcctgaa   1620
ttttcctaag gacttctgct ttgctcttca agaaatctgt gcctgagaac accagagacc   1680
tcaaattact ttgtgaatag aactctgaaa tgaagatggg cttcatccaa tggactgcat   1740
aaataaccgg ggattctgta catgcattga gctctctcat tgtctgtgta gagtgttata   1800
cttgggaata taaaggaggt gaccaaatca gtgtgaggag gtagatttgg ctcctctgct   1860
tctcacggga ctatttccac cacccccagt tagcaccatt aactcctcct gagctctgat   1920
aagagaatca acatttctca ataatttcct ccacaaatta ttaatgaaaa taagaattat   1980
tttgatggct ctaacaatga catttatatc acatgttttc tctggagtat tctataagtt   2040
ttatgttaaa tcaataaaga ccactttaca aaagtattat cagatgcttt cctgcacatt   2100
aaggagaaat ctatagaact gaatgagaac caacaagtaa atatttttgg tcattgtaat   2160
cactgttggc gtggggcctt tgtcagaact agaatttgat tattaacata ggtgaaagtt   2220
aatccactgt gactttgccc attgtttaga aagaatattc atagtttaat tatgcctttt   2280
ttgatcaggc acagtggctc acgcctgtaa tcctagcagt ttgggaggct gagccgggtg   2340
gatcgcctga ggtcaggagt tcaagacaag cctggcctac atggttgaaa ccccatctct   2400
actaaaaata cacaaattag ctaggcatgg tggactcgcc tgtaatctca ctacacagga   2460
ggctgaggca ggagaatcac ttgaacctgg gaggcggatg ttgaagtgag ctgagattgc   2520
accactgcac tccagtctgg gtgagagtga gactcagtct taaaaaaata tgcctttttg   2580
aagcacgtac attttgtaac aaagaactga agctcttatt atattattag ttttgattta   2640
atgttttcag cccatctcct ttcatatttc tgggagacag aaaacatgtt tccctacacc   2700
tcttgcattc catcctcaac acccaactgt ctcgatgcaa tgaacactta ataaaaaaca   2760
gtcgattggt caattgattg agcaataagc ct                                 2792


<210>  24

<211>  1658
<212>  DNA
<213>  Homo sapiens

<220>
<223>  CYP2D6 isoform 2 gene

<400>  24
gtgctgagag tgtcctgcct ggtcctctgt gcctggtggg gtgggggtgc caggtgtgtc     60
cagaggagcc catttggtag tgaggcaggt atggggctag aagcactggt gcccctggcc    120
gtgatagtgg ccatcttcct gctcctggtg gacctgatgc accggcgcca acgctgggct    180
gcacgctacc caccaggccc cctgccactg cccgggctgg gcaacctgct gcatgtggac    240
ttccagaaca caccatactg cttcgaccag ttgcggcgcc gcttcgggga cgtgttcagc    300
ctgcagctgg cctggacgcc ggtggtcgtg ctcaatgggc tggcggccgt gcgcgaggcg    360
ctggtgaccc acggcgagga caccgccgac cgcccgcctg tgcccatcac ccagatcctg    420
ggtttcgggc cgcgttccca aggggtgttc ctggcgcgct atgggcccgc gtggcgcgag    480
cagaggcgct tctccgtgtc caccttgcgc aacttgggcc tgggcaagaa gtcgctggag    540
cagtgggtga ccgaggaggc cgcctgcctt tgtgccgcct tcgccaacca ctccggacgc    600
ccctttcgcc ccaacggtct cttggacaaa gccgtgagca acgtgatcgc ctccctcacc    660
tgcgggcgcc gcttcgagta cgacgaccct cgcttcctca ggctgctgga cctagctcag    720
gagggactga aggaggagtc gggctttctg cgcgaggtgc tgaatgctgt ccccgtcctc    780
ctgcatatcc cagcgctggc tggcaaggtc ctacgcttcc aaaaggcttt cctgacccag    840
ctggatgagc tgctaactga gcacaggatg acctgggacc cagcccagcc cccccgagac    900
ctgactgagg ccttcctggc agagatggag aaggccaagg ggaaccctga gagcagcttc    960
aatgatgaga acctgcgcat agtggtggct gacctgttct ctgccgggat ggtgaccacc   1020
tcgaccacgc tggcctgggg cctcctgctc atgatcctac atccggatgt gcagcgccgt   1080
gtccaacagg agatcgacga cgtgataggg caggtgcggc gaccagagat gggtgaccag   1140
gctcacatgc cctacaccac tgccgtgatt catgaggtgc agcgctttgg ggacatcgtc   1200
cccctgggtg tgacccatat gacatcccgt gacatcgaag tacagggctt ccgcatccct   1260
aagggaacga cactcatcac caacctgtca tcggtgctga aggatgaggc cgtctgggag   1320
aagcccttcc gcttccaccc cgaacacttc ctggatgccc agggccactt tgtgaagccg   1380
gaggccttcc tgcctttctc agcaggccgc cgtgcatgcc tcggggagcc cctggcccgc   1440
atggagctct tcctcttctt cacctccctg ctgcagcact tcagcttctc ggtgcccact   1500
ggacagcccc ggcccagcca ccatggtgtc tttgctttcc tggtgagccc atccccctat   1560
gagctttgtg ctgtgccccg ctagaatggg gtacctagtc cccagcctgc tccctagcca   1620
gaggctctaa tgtacaataa agcaatgtgg tagttcca                           1658


<210>  25

<211>  1787
<212>  DNA
<213>  Homo sapiens

<220>
<223>  CYP2C19 gene

<400>  25
gtcttaacaa gaggagaagg cttcaatgga tccttttgtg gtccttgtgc tctgtctctc     60
atgtttgctt ctcctttcaa tctggagaca gagctctggg agaggaaaac tccctcctgg    120
ccccactcct ctcccagtga ttggaaatat cctacagata gatattaagg atgtcagcaa    180
atccttaacc aatctctcaa aaatctatgg ccctgtgttc actctgtatt ttggcctgga    240
acgcatggtg gtgctgcatg gatatgaagt ggtgaaggaa gccctgattg atcttggaga    300
ggagttttct ggaagaggcc atttcccact ggctgaaaga gctaacagag gatttggaat    360
cgttttcagc aatggaaaga gatggaagga gatccggcgt ttctccctca tgacgctgcg    420
gaattttggg atggggaaga ggagcattga ggaccgtgtt caagaggaag cccgctgcct    480
tgtggaggag ttgagaaaaa ccaaggcttc accctgtgat cccactttca tcctgggctg    540
tgctccctgc aatgtgatct gctccattat tttccagaaa cgtttcgatt ataaagatca    600
gcaatttctt aacttgatgg aaaaattgaa tgaaaacatc aggattgtaa gcaccccctg    660
gatccagata tgcaataatt ttcccactat cattgattat ttcccgggaa cccataacaa    720
attacttaaa aaccttgctt ttatggaaag tgatattttg gagaaagtaa aagaacacca    780
agaatcgatg gacatcaaca accctcggga ctttattgat tgcttcctga tcaaaatgga    840
gaaggaaaag caaaaccaac agtctgaatt cactattgaa aacttggtaa tcactgcagc    900
tgacttactt ggagctggga cagagacaac aagcacaacc ctgagatatg ctctccttct    960
cctgctgaag cacccagagg tcacagctaa agtccaggaa gagattgaac gtgtcattgg   1020
cagaaaccgg agcccctgca tgcaggacag gggccacatg ccctacacag atgctgtggt   1080
gcacgaggtc cagagataca tcgacctcat ccccaccagc ctgccccatg cagtgacctg   1140
tgacgttaaa ttcagaaact acctcattcc caagggcaca accatattaa cttccctcac   1200
ttctgtgcta catgacaaca aagaatttcc caacccagag atgtttgacc ctcgtcactt   1260
tctggatgaa ggtggaaatt ttaagaaaag taactacttc atgcctttct cagcaggaaa   1320
acggatttgt gtgggagagg gcctggcccg catggagctg tttttattcc tgaccttcat   1380
tttacagaac tttaacctga aatctctgat tgacccaaag gaccttgaca caactcctgt   1440
tgtcaatgga tttgcttctg tcccgccctt ctatcagctg tgcttcattc ctgtctgaag   1500
aagcacagat ggtctggctg ctcctgtgct gtccctgcag ctctctttcc tctggtccaa   1560
atttcactat ctgtgatgct tcttctgacc cgtcatctca cattttccct tcccccaaga   1620
tctagtgaac attcagcctc cattaaaaaa gtttcactgt gcaaatatat ctgctattcc   1680
ccatactcta taatagttac attgagtgcc acataatgct gatacttgtc taatgttgag   1740
ttattaacat attattatta aatagagaaa gatgatttgt gtattat                 1787


<210>  26

<211>  3127
<212>  DNA
<213>  Homo sapiens

<220>
<223>  CYP1A2 gene

<400>  26
gaagctccac accagccatt acaaccctgc caatctcaag cacctgcctc tacagttggt     60
acagatggca ttgtcccagt ctgttccctt ctcggccaca gagcttctcc tggcctctgc    120
catcttctgc ctggtattct gggtgctcaa gggtttgagg cctcgggtcc ccaaaggcct    180
gaaaagtcca ccagagccat ggggctggcc cttgctcggg catgtgctga ccctggggaa    240
gaacccgcac ctggcactgt caaggatgag ccagcgctac ggggacgtcc tgcagatccg    300
cattggctcc acgcccgtgc tggtgctgag ccgcctggac accatccggc aggccctggt    360
gcggcagggc gacgatttca agggccggcc tgacctctac acctccaccc tcatcactga    420
tggccagagc ttgaccttca gcacagactc tggaccggtg tgggctgccc gccggcgcct    480
ggcccagaat gccctcaaca ccttctccat cgcctctgac ccagcttcct catcctcctg    540
ctacctggag gagcatgtga gcaaggaggc taaggccctg atcagcaggt tgcaggagct    600
gatggcaggg cctgggcact tcgaccctta caatcaggtg gtggtgtcag tggccaacgt    660
cattggtgcc atgtgcttcg gacagcactt ccctgagagt agcgatgaga tgctcagcct    720
cgtgaagaac actcatgagt tcgtggagac tgcctcctcc gggaaccccc tggacttctt    780
ccccatcctt cgctacctgc ctaaccctgc cctgcagagg ttcaaggcct tcaaccagag    840
gttcctgtgg ttcctgcaga aaacagtcca ggagcactat caggactttg acaagaacag    900
tgtccgggac atcacgggtg ccctgttcaa gcacagcaag aaggggccta gagccagcgg    960
caacctcatc ccacaggaga agattgtcaa ccttgtcaat gacatctttg gagcaggatt   1020
tgacacagtc accacagcca tctcctggag cctcatgtac cttgtgacca agcctgagat   1080
acagaggaag atccagaagg agctggacac tgtgattggc agggagcggc ggccccggct   1140
ctctgacaga ccccagctgc cctacttgga ggccttcatc ctggagacct tccgacactc   1200
ctccttcttg cccttcacca tcccccacag cacaacaagg gacacaacgc tgaatggctt   1260
ctacatcccc aagaaatgct gtgtcttcgt aaaccagtgg caggtcaacc atgacccaga   1320
gctgtgggag gacccctctg agttccggcc tgagcggttc ctcaccgccg atggcactgc   1380
cattaacaag cccttgagtg agaagatgat gctgtttggc atgggcaagc gccggtgtat   1440
cggggaagtc ctggccaagt gggagatctt cctcttcctg gccatcctgc tacagcaact   1500
ggagttcagc gtgccgccgg gcgtgaaagt cgacctgacc cccatctacg ggctgaccat   1560
gaagcacgcc cgctgtgaac atgtccaggc gcggctgcgc ttctccatca attgaagaag   1620
acaccaccat tctgaggcca gggagcgagt gggggccagc cacggggact cagcccttgt   1680
ttctcttcct ttcttttttt aaaaaatagc agctttagcc aagtgcaggg cctgtaatcc   1740
cagcatttta ggaggccaag gttggaggat catttgagcc caggaattgg aaagcagcct   1800
ggccaacata gtgggaccct gtctctacaa aaaaaaaatt tgccaagagc ctgagtgaca   1860
gagcaagacc ccatctcaaa aaaaaaaaca aacaaacaaa aaaaaaacca tatatataca   1920
tatatatata gcagctttat ggagatataa ttcttatgcc atataattca ccttcttttt   1980
ttttttttgt ctgagacaga atctcagtct gtcacccagg ttggagtgca gtggcgtgat   2040
ctcagctcac tgcaacctcc acctcgcagg ttcaagcaat cctcccactt cagcctccca   2100
agcacctggg attacaagca tgagtcacta cgcctggctg atttttgtag ttttagtgga   2160
gatggggttt caccatgttg gccaggcttg tctcgaactc ctgaccccaa gttatccacc   2220
tgccttggct tcccaaagtc ctgggattac aggtgtgagc caccacatcc agcctaactt   2280
acattcttaa agtgtcgaat gacttctagt gtagaattgt gcaaccatca ccagaattaa   2340
ttttattatt cttattattt ttgagacaga gtcttactct gttgccaggc tggagtgcag   2400
tggcgcgatc tcagctcact acaacctccg cctcccatgt tcaagcgatt ctcctgcctc   2460
agcctcccga gtagctggga ctataggcat gcgccaccat ggccagctaa tttttgtatt   2520
tttagtagag acgaggtttc actgtgttgg ccaggatggt ctccatctct tgacctcgtg   2580
atccacccgc ctcagcctcc caaagtgctg ggattaacag gtatgaacca ccgcgcccag   2640
cctttttgtt tttttttttt ttgagacaga gtcttcctct gtctcctaag ctggagtgca   2700
gtggcatcat ctcagctcac tgcaacctct gcctcccagg ttcaagtgct tctccagcct   2760
cagcctccca agtagctgag actacaggca cacaccacca cgcctggcta atttttgtat   2820
ttttagtaga gacgggtttc accatgttgg ctagactagt ctcaaactcc tgacctcaag   2880
tgatctgccc gcctcgacct ctctcaaagt gctggcatta caggtgtgag ccacggtgcc   2940
cggcccacaa ttaattttag aacattttca tcacccctaa aagaaaccct gcacccatta   3000
gcagtccctc cacatttccc cctagcctgc ctcccctgcc tcaccagccc tggcaactgc   3060
taatctactt tctgtgtcta tggatttgcc ttctctaaac atttcatata aatggaatta   3120
cacaatg                                                             3127


<210>  27

<211>  2603
<212>  DNA
<213>  Homo sapiens

<220>
<223>  CYP2B6 gene

<400>  27
gcggagcgcg cacgcgggaa cccgcgctgg aggcgggcga gggccgaggg gcagctaggg     60
agcgcggctt gaggagggcg gggccgcccc gcaggcccgc cagtgtcctc agctgcctcc    120
gcgcgccaaa gtcaaacccc gacacccgcc ggcgggccgg tgagctcact agctgacccg    180
gcaggtcagg atctggctta gcggcgccgc gagctccagt gcgcgcaccc gtggccgcct    240
cccagccctc tttgccggac gagctctggg ccgccacaag actaaggaat ggccaccccg    300
cccaagagaa gctgcccgtc tttctcagcc agctctgagg ggacccgcat caagaaaatc    360
tccatcgaag ggaacatcgc tgcagggaag tcaacatttg tgaatatcct taaacaattg    420
tgtgaagatt gggaagtggt tcctgaacct gttgccagat ggtgcaatgt tcaaagtact    480
caagatgaat ttgaggaact tacaatgtct cagaaaaatg gtgggaatgt tcttcagatg    540
atgtatgaga aacctgaacg atggtctttt accttccaaa catatgcctg tctcagtcga    600
ataagagctc agcttgcctc tctgaatggc aagctcaaag atgcagagaa acctgtatta    660
ttttttgaac gatctgtgta tagtgacagg tatatttttg catctaattt gtatgaatct    720
gaatgcatga atgagacaga gtggacaatt tatcaagact ggcatgactg gatgaataac    780
caatttggcc aaagccttga attggatgga atcatttatc ttcaagccac tccagagaca    840
tgcttacata gaatatattt acggggaaga aatgaagagc aaggcattcc tcttgaatat    900
ttagagaagc ttcattataa acatgaaagc tggctcctgc ataggacact gaaaaccaac    960
ttcgattatc ttcaagaggt gcctatctta acactggatg ttaatgaaga ctttaaagac   1020
aaatatgaaa gtctggttga aaaggtcaaa gagtttttga gtactttgtg atcttgctga   1080
agactacagg cagccaaatg gttccagata cttcagcttt gtgtatcttc gtaacttcat   1140
attaatataa gtttctttag aaaacccaag tttttaatcg tttttgtttt aaggaaaaaa   1200
gatttttaaa atgaatctta tgcaaaactt tttgaccagt ttcttttctt ttgttttttt   1260
tttaaaaaag acatttaaag acaaagacat tatttctcat agcaggaaat gtagaggtag   1320
atggttccag tatcagcata gtgactaaac tacattataa aagatccagc ttccttctgt   1380
cattcccctc ttttgtcttc ctcagcaggt tggctttttt ccctggtgcc tctcacttcg   1440
ttggtgacca gtttcttaaa ctgaaagctt taatgttaca tagtaaatgg tagtgtgtcc   1500
tgtgtaaatt agtgtaccta ttaaaagttg caaagtggaa ttaaaggaat ccctagaata   1560
aggattctga agttttattt taaattatta tcttcttaac agtttagtcc cacctcttac   1620
ttcctgcctc agtctgcttt ctctactgtc tggattaatt aggcagcctg ctataaagtt   1680
aaagtcacac atttctattt tgcaaacact gtgattactc tttgctttgt agtttgcttt   1740
gctttgtagg gttctgcttt taagtttttc tctttttcag acaaattact gataaaaatg   1800
atattgctct atatgtaata tatcctgaaa gcattatttt ttgttgaata ggaaataaaa   1860
ttaatgaaga cagaggctag aaagcatcca ttaattaatg agacacactt aactacttat   1920
ctctaaacca tctatgtgaa tatttgtaaa aataatgaat ggactcatct tagttctgta   1980
tataaatata ttttctttct agtttgttta gttaaggtgt gcagtgtttt tcctgtgtat   2040
taaacctttc cattttacgt tttagaaaat tttatgtatt ttaaaataag gggaagagtc   2100
attttcactt ttaaactact atttttcttt ccaagtcatt tttgtttttg gtttcttatt   2160
caaagatgat aatttagtgg attaaccagt ccagacgcac tgatctttgc aaaggagact   2220
taatttcaaa tctgtaatta ccatacataa actgtctcat tatacgtatg cattttttta   2280
gtttgttttt gtttggtata aattaatttg ttaattaaat atttcttaag tataaacctt   2340
atgaactaca gtggagctac actcattgaa atgtaatttc agttctaaaa agatgtaata   2400
atcattttag aattaaaatt tattctactt ttaaataaat tatgaatatt aaaggtgaaa   2460
attgtataaa ttactttgat tccattttaa gtggagacat atttcagtga tttttagtaa   2520
cctttaaaaa tgtataatga cttttaaaat ttgtagaatt gaaaagacgc taataaaaat   2580
ttattattta tttgtcatga ctc                                           2603





