                         SEQUENCE LISTING

<110>   LifeSeq Limited Corporation
 
<120>  PD-L1PD-L2鵰׼;

<130>  PIDC1161471P

<160>  32    

<170>  PatentIn version 3.3

<210>  1
<211>  310
<212>  PRT
<213>  Artificial

<220>
<223>   PD-L1-PADRE Th-GM-CSF 鵰׵İ

<400>  1

Met Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly 
1               5                   10                  15      


Ser Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp 
            20                  25                  30          


Leu Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile 
        35                  40                  45              


Gln Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr 
    50                  55                  60                  


Arg Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala 
65                  70                  75                  80  


Ala Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg 
                85                  90                  95      


Cys Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys 
            100                 105                 110         


Val Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp 
        115                 120                 125             


Pro Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Ala Lys Phe 
    130                 135                 140                 


Val Ala Ala Trp Thr Leu Lys Ala Ala Ala Ser Gly Ser Gly Met Trp 
145                 150                 155                 160 


Leu Gln Ser Leu Leu Leu Leu Gly Thr Val Ala Cys Ser Ile Ser Ala 
                165                 170                 175     


Pro Ala Arg Ser Pro Ser Pro Ser Thr Gln Pro Trp Glu His Val Asn 
            180                 185                 190         


Ala Ile Gln Glu Ala Arg Arg Leu Leu Asn Leu Ser Arg Asp Thr Ala 
        195                 200                 205             


Ala Glu Met Asn Glu Thr Val Glu Val Ile Ser Glu Met Phe Asp Leu 
    210                 215                 220                 


Gln Glu Pro Thr Cys Leu Gln Thr Arg Leu Glu Leu Tyr Lys Gln Gly 
225                 230                 235                 240 


Leu Arg Gly Ser Leu Thr Lys Leu Lys Gly Pro Leu Thr Met Met Ala 
                245                 250                 255     


Ser His Tyr Lys Gln His Cys Pro Pro Thr Pro Glu Thr Ser Cys Ala 
            260                 265                 270         


Thr Gln Ile Ile Thr Phe Glu Ser Phe Lys Glu Asn Leu Lys Asp Phe 
        275                 280                 285             


Leu Leu Val Ile Pro Phe Asp Cys Trp Glu Pro Val Gln Glu Leu Glu 
    290                 295                 300                 


His His His His His His 
305                 310 


<210>  2
<211>  257
<212>  PRT
<213>  Artificial

<220>
<223>   PD-L1- PADRE Th - RANTES鵰׵İ

<400>  2

Met Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly 
1               5                   10                  15      


Ser Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp 
            20                  25                  30          


Leu Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile 
        35                  40                  45              


Gln Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr 
    50                  55                  60                  


Arg Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala 
65                  70                  75                  80  


Ala Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg 
                85                  90                  95      


Cys Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys 
            100                 105                 110         


Val Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp 
        115                 120                 125             


Pro Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Ala Lys Phe 
    130                 135                 140                 


Val Ala Ala Trp Thr Leu Lys Ala Ala Ala Ser Gly Ser Gly Met Lys 
145                 150                 155                 160 


Val Ser Ala Ala Arg Leu Ala Val Ile Leu Ile Ala Thr Ala Leu Cys 
                165                 170                 175     


Ala Pro Ala Ser Ala Ser Pro Tyr Ser Ser Asp Thr Thr Pro Cys Cys 
            180                 185                 190         


Phe Ala Tyr Ile Ala Arg Pro Leu Pro Arg Ala His Ile Lys Glu Tyr 
        195                 200                 205             


Phe Tyr Thr Ser Gly Lys Cys Ser Asn Pro Ala Val Val Phe Val Thr 
    210                 215                 220                 


Arg Lys Asn Arg Gln Val Cys Ala Asn Pro Glu Lys Lys Trp Val Arg 
225                 230                 235                 240 


Glu Tyr Ile Asn Ser Leu Glu Met Ser Leu Glu His His His His His 
                245                 250                 255     


His 
    


<210>  3
<211>  708
<212>  PRT
<213>  Artificial

<220>
<223>  PD-L1- PADRE Th -IL-12鵰׵İ

<400>  3

Met Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly 
1               5                   10                  15      


Ser Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp 
            20                  25                  30          


Leu Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile 
        35                  40                  45              


Gln Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr 
    50                  55                  60                  


Arg Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala 
65                  70                  75                  80  


Ala Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg 
                85                  90                  95      


Cys Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys 
            100                 105                 110         


Val Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp 
        115                 120                 125             


Pro Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Ala Lys Phe 
    130                 135                 140                 


Val Ala Ala Trp Thr Leu Lys Ala Ala Ala Val Asp Ser Gly Ser Gly 
145                 150                 155                 160 


Met Cys Pro Ala Arg Ser Leu Leu Leu Val Ala Thr Leu Val Leu Leu 
                165                 170                 175     


Asp His Leu Ser Leu Ala Arg Asn Leu Pro Val Ala Thr Pro Asp Pro 
            180                 185                 190         


Gly Met Phe Pro Cys Leu His His Ser Gln Asn Leu Leu Arg Ala Val 
        195                 200                 205             


Ser Asn Met Leu Gln Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys 
    210                 215                 220                 


Thr Ser Glu Glu Ile Asp His Glu Asp Ile Thr Lys Asp Lys Thr Ser 
225                 230                 235                 240 


Thr Val Glu Ala Cys Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys 
                245                 250                 255     


Leu Asn Ser Arg Glu Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala 
            260                 265                 270         


Ser Arg Lys Thr Ser Phe Met Met Ala Leu Cys Leu Ser Ser Ile Tyr 
        275                 280                 285             


Glu Asp Leu Lys Met Tyr Gln Val Glu Phe Lys Thr Met Asn Ala Lys 
    290                 295                 300                 


Leu Leu Met Asp Pro Lys Arg Gln Ile Phe Leu Asp Gln Asn Met Leu 
305                 310                 315                 320 


Ala Val Ile Asp Glu Leu Met Gln Ala Leu Asn Phe Asn Ser Glu Thr 
                325                 330                 335     


Val Pro Gln Lys Ser Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys 
            340                 345                 350         


Ile Lys Leu Cys Ile Leu Leu His Ala Phe Arg Ile Arg Ala Val Thr 
        355                 360                 365             


Ile Asp Arg Val Met Ser Tyr Leu Asn Ala Ser Gly Gly Gly Gly Ser 
    370                 375                 380                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ile Trp Glu Leu Lys Lys 
385                 390                 395                 400 


Asp Val Tyr Val Val Glu Leu Asp Trp Tyr Pro Asp Ala Pro Gly Glu 
                405                 410                 415     


Met Val Val Leu Thr Cys Asp Thr Pro Glu Glu Asp Gly Ile Thr Trp 
            420                 425                 430         


Thr Leu Asp Gln Ser Ser Glu Val Leu Gly Ser Gly Lys Thr Leu Thr 
        435                 440                 445             


Ile Gln Val Lys Glu Phe Gly Asp Ala Gly Gln Tyr Thr Cys His Lys 
    450                 455                 460                 


Gly Gly Glu Val Leu Ser His Ser Leu Leu Leu Leu His Lys Lys Glu 
465                 470                 475                 480 


Asp Gly Ile Trp Ser Thr Asp Ile Leu Lys Asp Gln Lys Glu Pro Lys 
                485                 490                 495     


Asn Lys Thr Phe Leu Arg Cys Glu Ala Lys Asn Tyr Ser Gly Arg Phe 
            500                 505                 510         


Thr Cys Trp Trp Leu Thr Thr Ile Ser Thr Asp Leu Thr Phe Ser Val 
        515                 520                 525             


Lys Ser Ser Arg Gly Ser Ser Asp Pro Gln Gly Val Thr Cys Gly Ala 
    530                 535                 540                 


Ala Thr Leu Ser Ala Glu Arg Val Arg Gly Asp Asn Lys Glu Tyr Glu 
545                 550                 555                 560 


Tyr Ser Val Glu Cys Gln Glu Asp Ser Ala Cys Pro Ala Ala Glu Glu 
                565                 570                 575     


Ser Leu Pro Ile Glu Val Met Val Asp Ala Val His Lys Leu Lys Tyr 
            580                 585                 590         


Glu Asn Tyr Thr Ser Ser Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp 
        595                 600                 605             


Pro Pro Lys Asn Leu Gln Leu Lys Pro Leu Lys Asn Ser Arg Gln Val 
    610                 615                 620                 


Glu Val Ser Trp Glu Tyr Pro Asp Thr Trp Ser Thr Pro His Ser Tyr 
625                 630                 635                 640 


Phe Ser Leu Thr Phe Cys Val Gln Val Gln Gly Lys Ser Lys Arg Glu 
                645                 650                 655     


Lys Lys Asp Arg Val Phe Thr Asp Lys Thr Ser Ala Thr Val Ile Cys 
            660                 665                 670         


Arg Lys Asn Ala Ser Ile Ser Val Arg Ala Gln Asp Arg Tyr Tyr Ser 
        675                 680                 685             


Ser Ser Trp Ser Glu Trp Ala Ser Val Pro Cys Ser Leu Glu His His 
    690                 695                 700                 


His His His His 
705             


<210>  4
<211>  312
<212>  PRT
<213>  Artificial

<220>
<223>  PD-L2- PADRE Th - GM-CSF鵰׵İ

<400>  4

Met Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu His 
1               5                   10                  15      


Gly Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val 
            20                  25                  30          


Asn Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr 
        35                  40                  45              


Ser Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu 
    50                  55                  60                  


Gly Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly 
65                  70                  75                  80  


Gln Tyr Gln Cys Ile Ile Ile Tyr Gly Val Ala Trp Asp Tyr Lys Tyr 
                85                  90                  95      


Leu Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile 
            100                 105                 110         


Leu Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr 
        115                 120                 125             


Gly Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Ala Lys Phe 
    130                 135                 140                 


Val Ala Ala Trp Thr Leu Lys Ala Ala Ala Val Asp Ser Gly Ser Gly 
145                 150                 155                 160 


Met Trp Leu Gln Ser Leu Leu Leu Leu Gly Thr Val Ala Cys Ser Ile 
                165                 170                 175     


Ser Ala Pro Ala Arg Ser Pro Ser Pro Ser Thr Gln Pro Trp Glu His 
            180                 185                 190         


Val Asn Ala Ile Gln Glu Ala Arg Arg Leu Leu Asn Leu Ser Arg Asp 
        195                 200                 205             


Thr Ala Ala Glu Met Asn Glu Thr Val Glu Val Ile Ser Glu Met Phe 
    210                 215                 220                 


Asp Leu Gln Glu Pro Thr Cys Leu Gln Thr Arg Leu Glu Leu Tyr Lys 
225                 230                 235                 240 


Gln Gly Leu Arg Gly Ser Leu Thr Lys Leu Lys Gly Pro Leu Thr Met 
                245                 250                 255     


Met Ala Ser His Tyr Lys Gln His Cys Pro Pro Thr Pro Glu Thr Ser 
            260                 265                 270         


Cys Ala Thr Gln Ile Ile Thr Phe Glu Ser Phe Lys Glu Asn Leu Lys 
        275                 280                 285             


Asp Phe Leu Leu Val Ile Pro Phe Asp Cys Trp Glu Pro Val Gln Glu 
    290                 295                 300                 


Leu Glu His His His His His His 
305                 310         


<210>  5
<211>  259
<212>  PRT
<213>  Artificial

<220>
<223>  PD-L2 - PADRE Th - RANTES鵰׵İ

<400>  5

Met Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu His 
1               5                   10                  15      


Gly Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val 
            20                  25                  30          


Asn Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr 
        35                  40                  45              


Ser Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu 
    50                  55                  60                  


Gly Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly 
65                  70                  75                  80  


Gln Tyr Gln Cys Ile Ile Ile Tyr Gly Val Ala Trp Asp Tyr Lys Tyr 
                85                  90                  95      


Leu Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile 
            100                 105                 110         


Leu Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr 
        115                 120                 125             


Gly Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Ala Lys Phe 
    130                 135                 140                 


Val Ala Ala Trp Thr Leu Lys Ala Ala Ala Val Asp Ser Gly Ser Gly 
145                 150                 155                 160 


Met Lys Val Ser Ala Ala Arg Leu Ala Val Ile Leu Ile Ala Thr Ala 
                165                 170                 175     


Leu Cys Ala Pro Ala Ser Ala Ser Pro Tyr Ser Ser Asp Thr Thr Pro 
            180                 185                 190         


Cys Cys Phe Ala Tyr Ile Ala Arg Pro Leu Pro Arg Ala His Ile Lys 
        195                 200                 205             


Glu Tyr Phe Tyr Thr Ser Gly Lys Cys Ser Asn Pro Ala Val Val Phe 
    210                 215                 220                 


Val Thr Arg Lys Asn Arg Gln Val Cys Ala Asn Pro Glu Lys Lys Trp 
225                 230                 235                 240 


Val Arg Glu Tyr Ile Asn Ser Leu Glu Met Ser Leu Glu His His His 
                245                 250                 255     


His His His 
            


<210>  6
<211>  708
<212>  PRT
<213>  Artificial

<220>
<223>  PD-L2 - PADRE Th -IL-12鵰׵İ

<400>  6

Met Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu His 
1               5                   10                  15      


Gly Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val 
            20                  25                  30          


Asn Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr 
        35                  40                  45              


Ser Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu 
    50                  55                  60                  


Gly Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly 
65                  70                  75                  80  


Gln Tyr Gln Cys Ile Ile Ile Tyr Gly Val Ala Trp Asp Tyr Lys Tyr 
                85                  90                  95      


Leu Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile 
            100                 105                 110         


Leu Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr 
        115                 120                 125             


Gly Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Ala Lys Phe 
    130                 135                 140                 


Val Ala Ala Trp Thr Leu Lys Ala Ala Ala Val Asp Ser Gly Ser Gly 
145                 150                 155                 160 


Met Cys Pro Ala Arg Ser Leu Leu Leu Val Ala Thr Leu Val Leu Leu 
                165                 170                 175     


Asp His Leu Ser Leu Ala Arg Asn Leu Pro Val Ala Thr Pro Asp Pro 
            180                 185                 190         


Gly Met Phe Pro Cys Leu His His Ser Gln Asn Leu Leu Arg Ala Val 
        195                 200                 205             


Ser Asn Met Leu Gln Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys 
    210                 215                 220                 


Thr Ser Glu Glu Ile Asp His Glu Asp Ile Thr Lys Asp Lys Thr Ser 
225                 230                 235                 240 


Thr Val Glu Ala Cys Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys 
                245                 250                 255     


Leu Asn Ser Arg Glu Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala 
            260                 265                 270         


Ser Arg Lys Thr Ser Phe Met Met Ala Leu Cys Leu Ser Ser Ile Tyr 
        275                 280                 285             


Glu Asp Leu Lys Met Tyr Gln Val Glu Phe Lys Thr Met Asn Ala Lys 
    290                 295                 300                 


Leu Leu Met Asp Pro Lys Arg Gln Ile Phe Leu Asp Gln Asn Met Leu 
305                 310                 315                 320 


Ala Val Ile Asp Glu Leu Met Gln Ala Leu Asn Phe Asn Ser Glu Thr 
                325                 330                 335     


Val Pro Gln Lys Ser Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys 
            340                 345                 350         


Ile Lys Leu Cys Ile Leu Leu His Ala Phe Arg Ile Arg Ala Val Thr 
        355                 360                 365             


Ile Asp Arg Val Met Ser Tyr Leu Asn Ala Ser Gly Gly Gly Gly Ser 
    370                 375                 380                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ile Trp Glu Leu Lys Lys 
385                 390                 395                 400 


Asp Val Tyr Val Val Glu Leu Asp Trp Tyr Pro Asp Ala Pro Gly Glu 
                405                 410                 415     


Met Val Val Leu Thr Cys Asp Thr Pro Glu Glu Asp Gly Ile Thr Trp 
            420                 425                 430         


Thr Leu Asp Gln Ser Ser Glu Val Leu Gly Ser Gly Lys Thr Leu Thr 
        435                 440                 445             


Ile Gln Val Lys Glu Phe Gly Asp Ala Gly Gln Tyr Thr Cys His Lys 
    450                 455                 460                 


Gly Gly Glu Val Leu Ser His Ser Leu Leu Leu Leu His Lys Lys Glu 
465                 470                 475                 480 


Asp Gly Ile Trp Ser Thr Asp Ile Leu Lys Asp Gln Lys Glu Pro Lys 
                485                 490                 495     


Asn Lys Thr Phe Leu Arg Cys Glu Ala Lys Asn Tyr Ser Gly Arg Phe 
            500                 505                 510         


Thr Cys Trp Trp Leu Thr Thr Ile Ser Thr Asp Leu Thr Phe Ser Val 
        515                 520                 525             


Lys Ser Ser Arg Gly Ser Ser Asp Pro Gln Gly Val Thr Cys Gly Ala 
    530                 535                 540                 


Ala Thr Leu Ser Ala Glu Arg Val Arg Gly Asp Asn Lys Glu Tyr Glu 
545                 550                 555                 560 


Tyr Ser Val Glu Cys Gln Glu Asp Ser Ala Cys Pro Ala Ala Glu Glu 
                565                 570                 575     


Ser Leu Pro Ile Glu Val Met Val Asp Ala Val His Lys Leu Lys Tyr 
            580                 585                 590         


Glu Asn Tyr Thr Ser Ser Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp 
        595                 600                 605             


Pro Pro Lys Asn Leu Gln Leu Lys Pro Leu Lys Asn Ser Arg Gln Val 
    610                 615                 620                 


Glu Val Ser Trp Glu Tyr Pro Asp Thr Trp Ser Thr Pro His Ser Tyr 
625                 630                 635                 640 


Phe Ser Leu Thr Phe Cys Val Gln Val Gln Gly Lys Ser Lys Arg Glu 
                645                 650                 655     


Lys Lys Asp Arg Val Phe Thr Asp Lys Thr Ser Ala Thr Val Ile Cys 
            660                 665                 670         


Arg Lys Asn Ala Ser Ile Ser Val Arg Ala Gln Asp Arg Tyr Tyr Ser 
        675                 680                 685             


Ser Ser Trp Ser Glu Trp Ala Ser Val Pro Cys Ser Leu Glu His His 
    690                 695                 700                 


His His His His 
705             


<210>  7
<211>  452
<212>  PRT
<213>  Artificial

<220>
<223>  PD-L1-PD-L2- PADRE Th -GM-CSF鵰׵İ

<400>  7

Met Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly 
1               5                   10                  15      


Ser Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp 
            20                  25                  30          


Leu Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile 
        35                  40                  45              


Gln Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr 
    50                  55                  60                  


Arg Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala 
65                  70                  75                  80  


Ala Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg 
                85                  90                  95      


Cys Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys 
            100                 105                 110         


Val Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp 
        115                 120                 125             


Pro Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Leu Phe Thr 
    130                 135                 140                 


Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu His Gly Ser Asn Val 
145                 150                 155                 160 


Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn Leu Gly Ala 
                165                 170                 175     


Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser Pro His Arg 
            180                 185                 190         


Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly Lys Ala Ser 
        195                 200                 205             


Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln Tyr Gln Cys 
    210                 215                 220                 


Ile Ile Ile Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu Thr Leu Lys 
225                 230                 235                 240 


Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu Lys Val Pro 
                245                 250                 255     


Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly Tyr Pro Leu 
            260                 265                 270         


Ala Glu Val Ser Trp Pro Asn Val Ser Ala Lys Phe Val Ala Ala Trp 
        275                 280                 285             


Thr Leu Lys Ala Ala Ala Val Asp Ser Gly Ser Gly Met Trp Leu Gln 
    290                 295                 300                 


Ser Leu Leu Leu Leu Gly Thr Val Ala Cys Ser Ile Ser Ala Pro Ala 
305                 310                 315                 320 


Arg Ser Pro Ser Pro Ser Thr Gln Pro Trp Glu His Val Asn Ala Ile 
                325                 330                 335     


Gln Glu Ala Arg Arg Leu Leu Asn Leu Ser Arg Asp Thr Ala Ala Glu 
            340                 345                 350         


Met Asn Glu Thr Val Glu Val Ile Ser Glu Met Phe Asp Leu Gln Glu 
        355                 360                 365             


Pro Thr Cys Leu Gln Thr Arg Leu Glu Leu Tyr Lys Gln Gly Leu Arg 
    370                 375                 380                 


Gly Ser Leu Thr Lys Leu Lys Gly Pro Leu Thr Met Met Ala Ser His 
385                 390                 395                 400 


Tyr Lys Gln His Cys Pro Pro Thr Pro Glu Thr Ser Cys Ala Thr Gln 
                405                 410                 415     


Ile Ile Thr Phe Glu Ser Phe Lys Glu Asn Leu Lys Asp Phe Leu Leu 
            420                 425                 430         


Val Ile Pro Phe Asp Cys Trp Glu Pro Val Gln Glu Leu Glu His His 
        435                 440                 445             


His His His His 
    450         


<210>  8
<211>  399
<212>  PRT
<213>  Artificial

<220>
<223>  PD-L1-PD-L2- PADRE Th- RANTES鵰׵İ

<400>  8

Met Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly 
1               5                   10                  15      


Ser Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp 
            20                  25                  30          


Leu Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile 
        35                  40                  45              


Gln Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr 
    50                  55                  60                  


Arg Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala 
65                  70                  75                  80  


Ala Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg 
                85                  90                  95      


Cys Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys 
            100                 105                 110         


Val Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp 
        115                 120                 125             


Pro Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Leu Phe Thr 
    130                 135                 140                 


Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu His Gly Ser Asn Val 
145                 150                 155                 160 


Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn Leu Gly Ala 
                165                 170                 175     


Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser Pro His Arg 
            180                 185                 190         


Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly Lys Ala Ser 
        195                 200                 205             


Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln Tyr Gln Cys 
    210                 215                 220                 


Ile Ile Ile Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu Thr Leu Lys 
225                 230                 235                 240 


Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu Lys Val Pro 
                245                 250                 255     


Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly Tyr Pro Leu 
            260                 265                 270         


Ala Glu Val Ser Trp Pro Asn Val Ser Ala Lys Phe Val Ala Ala Trp 
        275                 280                 285             


Thr Leu Lys Ala Ala Ala Val Asp Ser Gly Ser Gly Met Lys Val Ser 
    290                 295                 300                 


Ala Ala Arg Leu Ala Val Ile Leu Ile Ala Thr Ala Leu Cys Ala Pro 
305                 310                 315                 320 


Ala Ser Ala Ser Pro Tyr Ser Ser Asp Thr Thr Pro Cys Cys Phe Ala 
                325                 330                 335     


Tyr Ile Ala Arg Pro Leu Pro Arg Ala His Ile Lys Glu Tyr Phe Tyr 
            340                 345                 350         


Thr Ser Gly Lys Cys Ser Asn Pro Ala Val Val Phe Val Thr Arg Lys 
        355                 360                 365             


Asn Arg Gln Val Cys Ala Asn Pro Glu Lys Lys Trp Val Arg Glu Tyr 
    370                 375                 380                 


Ile Asn Ser Leu Glu Met Ser Leu Glu His His His His His His 
385                 390                 395                 


<210>  9
<211>  848
<212>  PRT
<213>  Artificial

<220>
<223>  PD-L1-PD-L2- PADRE Th-IL-12鵰׵İ

<400>  9

Met Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly 
1               5                   10                  15      


Ser Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp 
            20                  25                  30          


Leu Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile 
        35                  40                  45              


Gln Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr 
    50                  55                  60                  


Arg Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala 
65                  70                  75                  80  


Ala Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg 
                85                  90                  95      


Cys Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys 
            100                 105                 110         


Val Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp 
        115                 120                 125             


Pro Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Leu Phe Thr 
    130                 135                 140                 


Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu His Gly Ser Asn Val 
145                 150                 155                 160 


Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn Leu Gly Ala 
                165                 170                 175     


Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser Pro His Arg 
            180                 185                 190         


Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly Lys Ala Ser 
        195                 200                 205             


Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln Tyr Gln Cys 
    210                 215                 220                 


Ile Ile Ile Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu Thr Leu Lys 
225                 230                 235                 240 


Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu Lys Val Pro 
                245                 250                 255     


Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly Tyr Pro Leu 
            260                 265                 270         


Ala Glu Val Ser Trp Pro Asn Val Ser Ala Lys Phe Val Ala Ala Trp 
        275                 280                 285             


Thr Leu Lys Ala Ala Ala Val Asp Ser Gly Ser Gly Met Cys Pro Ala 
    290                 295                 300                 


Arg Ser Leu Leu Leu Val Ala Thr Leu Val Leu Leu Asp His Leu Ser 
305                 310                 315                 320 


Leu Ala Arg Asn Leu Pro Val Ala Thr Pro Asp Pro Gly Met Phe Pro 
                325                 330                 335     


Cys Leu His His Ser Gln Asn Leu Leu Arg Ala Val Ser Asn Met Leu 
            340                 345                 350         


Gln Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys Thr Ser Glu Glu 
        355                 360                 365             


Ile Asp His Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr Val Glu Ala 
    370                 375                 380                 


Cys Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys Leu Asn Ser Arg 
385                 390                 395                 400 


Glu Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala Ser Arg Lys Thr 
                405                 410                 415     


Ser Phe Met Met Ala Leu Cys Leu Ser Ser Ile Tyr Glu Asp Leu Lys 
            420                 425                 430         


Met Tyr Gln Val Glu Phe Lys Thr Met Asn Ala Lys Leu Leu Met Asp 
        435                 440                 445             


Pro Lys Arg Gln Ile Phe Leu Asp Gln Asn Met Leu Ala Val Ile Asp 
    450                 455                 460                 


Glu Leu Met Gln Ala Leu Asn Phe Asn Ser Glu Thr Val Pro Gln Lys 
465                 470                 475                 480 


Ser Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys Ile Lys Leu Cys 
                485                 490                 495     


Ile Leu Leu His Ala Phe Arg Ile Arg Ala Val Thr Ile Asp Arg Val 
            500                 505                 510         


Met Ser Tyr Leu Asn Ala Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        515                 520                 525             


Ser Gly Gly Gly Gly Ser Ile Trp Glu Leu Lys Lys Asp Val Tyr Val 
    530                 535                 540                 


Val Glu Leu Asp Trp Tyr Pro Asp Ala Pro Gly Glu Met Val Val Leu 
545                 550                 555                 560 


Thr Cys Asp Thr Pro Glu Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln 
                565                 570                 575     


Ser Ser Glu Val Leu Gly Ser Gly Lys Thr Leu Thr Ile Gln Val Lys 
            580                 585                 590         


Glu Phe Gly Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Val 
        595                 600                 605             


Leu Ser His Ser Leu Leu Leu Leu His Lys Lys Glu Asp Gly Ile Trp 
    610                 615                 620                 


Ser Thr Asp Ile Leu Lys Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe 
625                 630                 635                 640 


Leu Arg Cys Glu Ala Lys Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp 
                645                 650                 655     


Leu Thr Thr Ile Ser Thr Asp Leu Thr Phe Ser Val Lys Ser Ser Arg 
            660                 665                 670         


Gly Ser Ser Asp Pro Gln Gly Val Thr Cys Gly Ala Ala Thr Leu Ser 
        675                 680                 685             


Ala Glu Arg Val Arg Gly Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu 
    690                 695                 700                 


Cys Gln Glu Asp Ser Ala Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile 
705                 710                 715                 720 


Glu Val Met Val Asp Ala Val His Lys Leu Lys Tyr Glu Asn Tyr Thr 
                725                 730                 735     


Ser Ser Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn 
            740                 745                 750         


Leu Gln Leu Lys Pro Leu Lys Asn Ser Arg Gln Val Glu Val Ser Trp 
        755                 760                 765             


Glu Tyr Pro Asp Thr Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Thr 
    770                 775                 780                 


Phe Cys Val Gln Val Gln Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg 
785                 790                 795                 800 


Val Phe Thr Asp Lys Thr Ser Ala Thr Val Ile Cys Arg Lys Asn Ala 
                805                 810                 815     


Ser Ile Ser Val Arg Ala Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser 
            820                 825                 830         


Glu Trp Ala Ser Val Pro Cys Ser Leu Glu His His His His His His 
        835                 840                 845             


<210>  10
<211>  930
<212>  DNA
<213>  Artificial

<220>
<223>  PD-L1- PADRE Th-GM-CSF鵰׵ĺĺ

<400>  10
atgtttactg tcacggttcc caaggaccta tatgtggtag agtatggtag caatatgaca     60

attgaatgca aattcccagt agaaaaacaa ttagacctgg ctgcactaat tgtctattgg    120

gaaatggagg ataagaacat tattcaattt gtgcatggag aggaagacct gaaggttcag    180

catagtagct acagacagag ggcccggctg ttgaaggacc agctctccct gggaaatgct    240

gcacttcaga tcacagatgt gaaattgcag gatgcagggg tgtaccgctg catgatcagc    300

tatggtggtg ccgactacaa gcgaattact gtgaaagtca atgccccata caacaaaatc    360

aaccaaagaa ttttggttgt ggatccagtc acctctgaac atgaactgac atgtcaggct    420

gaggcgaaat ttgtggcggc gtggaccctg aaagcggcgg cgagcggcag cggcatgtgg    480

ctgcagagcc tgctgctctt gggcactgtg gcctgcagca tctctgcacc cgcccgctcg    540

cccagcccca gcacacagcc ctgggagcat gtgaatgcca tccaggaggc ccggcgtctc    600

ctgaacctga gtagagacac tgctgctgag atgaatgaaa cagtagaagt catctcagaa    660

atgtttgacc tccaggagcc gacctgccta cagacccgcc tggagctgta caagcagggc    720

ctgcggggca gcctcaccaa gctcaagggc cccttgacca tgatggccag ccactacaaa    780

cagcactgcc ctccaacccc ggaaacttcc tgtgcaaccc agattatcac ctttgaaagt    840

ttcaaagaga acctgaagga ctttctgctt gtcatcccct ttgactgctg ggagccagtc    900

caggagctcg agcaccacca ccaccaccac                                     930


<210>  11
<211>  771
<212>  DNA
<213>  Artificial

<220>
<223>  PD-L1- PADRE Th- RANTES鵰׵ĺĺ

<400>  11
atgtttactg tcacggttcc caaggaccta tatgtggtag agtatggtag caatatgaca     60

attgaatgca aattcccagt agaaaaacaa ttagacctgg ctgcactaat tgtctattgg    120

gaaatggagg ataagaacat tattcaattt gtgcatggag aggaagacct gaaggttcag    180

catagtagct acagacagag ggcccggctg ttgaaggacc agctctccct gggaaatgct    240

gcacttcaga tcacagatgt gaaattgcag gatgcagggg tgtaccgctg catgatcagc    300

tatggtggtg ccgactacaa gcgaattact gtgaaagtca atgccccata caacaaaatc    360

aaccaaagaa ttttggttgt ggatccagtc acctctgaac atgaactgac atgtcaggct    420

gaggcgaaat ttgtggcggc gtggaccctg aaagcggcgg cgagcggcag cggcatgaag    480

gtctccgcgg cacgcctcgc tgtcatcctc attgctactg ccctctgcgc tcctgcatct    540

gcctccccat attcctcgga caccacaccc tgctgctttg cctacattgc ccgcccactg    600

ccccgtgccc acatcaagga gtatttctac accagtggca agtgctccaa cccagcagtc    660

gtctttgtca cccgaaagaa ccgccaagtg tgtgccaacc cagagaagaa atgggttcgg    720

gagtacatca actctttgga gatgagcctc gagcaccacc accaccacca c             771


<210>  12
<211>  2124
<212>  DNA
<213>  Artificial

<220>
<223>  PD-L1- PADRE Th-IL-12 鵰׵ĺĺ

<400>  12
atgtttactg tcacggttcc caaggaccta tatgtggtag agtatggtag caatatgaca     60

attgaatgca aattcccagt agaaaaacaa ttagacctgg ctgcactaat tgtctattgg    120

gaaatggagg ataagaacat tattcaattt gtgcatggag aggaagacct gaaggttcag    180

catagtagct acagacagag ggcccggctg ttgaaggacc agctctccct gggaaatgct    240

gcacttcaga tcacagatgt gaaattgcag gatgcagggg tgtaccgctg catgatcagc    300

tatggtggtg ccgactacaa gcgaattact gtgaaagtca atgccccata caacaaaatc    360

aaccaaagaa ttttggttgt ggatccagtc acctctgaac atgaactgac atgtcaggct    420

gaggcgaaat ttgtggcggc gtggaccctg aaagcggcgg cggtcgacag cggcagcggc    480

atgtgtccag cgcgcagcct cctccttgtg gctaccctgg tcctcctgga ccacctcagt    540

ttggccagaa acctccccgt ggccactcca gacccaggaa tgttcccatg ccttcaccac    600

tcccaaaacc tgctgagggc cgtcagcaac atgctccaga aggccagaca aactctagaa    660

ttttaccctt gcacttctga agagattgat catgaagata tcacaaaaga taaaaccagc    720

acagtggagg cctgtttacc attggaatta accaagaatg agagttgcct aaattccaga    780

gagacctctt tcataactaa tgggagttgc ctggcctcca gaaagacctc ttttatgatg    840

gccctgtgcc ttagtagtat ttatgaagac ttgaagatgt accaggtgga gttcaagacc    900

atgaatgcaa agcttctgat ggatcctaag aggcagatct ttctagatca aaacatgctg    960

gcagttattg atgagctgat gcaggccctg aatttcaaca gtgagactgt gccacaaaaa   1020

tcctcccttg aagaaccgga tttttataaa actaaaatca agctctgcat acttcttcat   1080

gctttcagaa ttcgggcagt gactattgat agagtgatga gctatctgaa tgcttccggt   1140

ggcggtggct cgggcggtgg tgggtcgggt ggcggcggat ctatatggga actgaagaaa   1200

gatgtttatg tcgtagaatt ggattggtat ccggatgccc ctggagaaat ggtggtcctc   1260

acctgtgaca cccctgaaga agatggtatc acctggacct tggaccagag cagtgaggtc   1320

ttaggctctg gcaaaaccct gaccatccaa gtcaaagagt ttggagatgc tggccagtac   1380

acctgtcaca aaggaggcga ggttctaagc cattcgctcc tgctgcttca caaaaaggaa   1440

gatggaattt ggtccactga tattttaaag gaccagaaag aacccaaaaa taagaccttt   1500

ctaagatgcg aggccaagaa ttattctgga cgtttcacct gctggtggct gacgacaatc   1560

agtactgatt tgacattcag tgtcaaaagc agcagaggct cttctgaccc ccaaggggtg   1620

acgtgcggag ctgctacact ctctgcagag agagtcagag gggacaacaa ggagtatgag   1680

tactcagtgg agtgccagga ggacagtgcc tgcccagctg ctgaggagag tctgcccatt   1740

gaggtcatgg tggatgccgt tcacaagctc aagtatgaaa actacaccag cagcttcttc   1800

atcagggaca tcatcaaacc tgacccaccc aagaacttgc agctgaagcc attaaagaat   1860

tctcggcagg tggaggtcag ctgggagtac cctgacacct ggagtactcc acattcctac   1920

ttctccctga cattctgcgt tcaggtccag ggcaagagca agagagaaaa gaaagataga   1980

gtcttcacgg acaagacctc agccacggtc atctgccgca aaaatgccag cattagcgtg   2040

cgggcccagg accgctacta tagctcatct tggagcgaat gggcatctgt gccctgcagt   2100

ctcgagcacc accaccacca ccac                                          2124


<210>  13
<211>  936
<212>  DNA
<213>  Artificial

<220>
<223>  PD-L2- PADRE Th- GM-CSF鵰׵ĺĺ

<400>  13
atgttattca cagtgacagt ccctaaggaa ctgtacataa tagagcatgg cagcaatgtg     60

accctggaat gcaactttga cactggaagt catgtgaacc ttggagcaat aacagccagt    120

ttgcaaaagg tggaaaatga tacatcccca caccgtgaaa gagccacttt gctggaggag    180

cagctgcccc tagggaaggc ctcgttccac atacctcaag tccaagtgag ggacgaagga    240

cagtaccaat gcataatcat ctatggggtc gcctgggact acaagtacct gactctgaaa    300

gtcaaagctt cctacaggaa aataaacact cacatcctaa aggttccaga aacagatgag    360

gtagagctca cctgccaggc tacaggttat cctctggcag aagtatcctg gccaaacgtc    420

agcgcgaaat ttgtggcggc gtggaccctg aaagcggcgg cggtcgacag cggcagcggc    480

atgtggctgc agagcctgct gctcttgggc actgtggcct gcagcatctc tgcacccgcc    540

cgctcgccca gccccagcac acagccctgg gagcatgtga atgccatcca ggaggcccgg    600

cgtctcctga acctgagtag agacactgct gctgagatga atgaaacagt agaagtcatc    660

tcagaaatgt ttgacctcca ggagccgacc tgcctacaga cccgcctgga gctgtacaag    720

cagggcctgc ggggcagcct caccaagctc aagggcccct tgaccatgat ggccagccac    780

tacaaacagc actgccctcc aaccccggaa acttcctgtg caacccagat tatcaccttt    840

gaaagtttca aagagaacct gaaggacttt ctgcttgtca tcccctttga ctgctgggag    900

ccagtccagg agctcgagca ccaccaccac caccac                              936


<210>  14
<211>  777
<212>  DNA
<213>  Artificial

<220>
<223>  PD-L2- PADRE Th- RANTES鵰׵ĺĺ

<400>  14
atgttattca cagtgacagt ccctaaggaa ctgtacataa tagagcatgg cagcaatgtg     60

accctggaat gcaactttga cactggaagt catgtgaacc ttggagcaat aacagccagt    120

ttgcaaaagg tggaaaatga tacatcccca caccgtgaaa gagccacttt gctggaggag    180

cagctgcccc tagggaaggc ctcgttccac atacctcaag tccaagtgag ggacgaagga    240

cagtaccaat gcataatcat ctatggggtc gcctgggact acaagtacct gactctgaaa    300

gtcaaagctt cctacaggaa aataaacact cacatcctaa aggttccaga aacagatgag    360

gtagagctca cctgccaggc tacaggttat cctctggcag aagtatcctg gccaaacgtc    420

agcgcgaaat ttgtggcggc gtggaccctg aaagcggcgg cggtcgacag cggcagcggc    480

atgaaggtct ccgcggcacg cctcgctgtc atcctcattg ctactgccct ctgcgctcct    540

gcatctgcct ccccatattc ctcggacacc acaccctgct gctttgccta cattgcccgc    600

ccactgcccc gtgcccacat caaggagtat ttctacacca gtggcaagtg ctccaaccca    660

gcagtcgtct ttgtcacccg aaagaaccgc caagtgtgtg ccaacccaga gaagaaatgg    720

gttcgggagt acatcaactc tttggagatg agcctcgagc accaccacca ccaccac       777


<210>  15
<211>  2124
<212>  DNA
<213>  Artificial

<220>
<223>  PD-L2 - PADRE Th-IL-12鵰׵ĺĺ

<400>  15
atgttattca cagtgacagt ccctaaggaa ctgtacataa tagagcatgg cagcaatgtg     60

accctggaat gcaactttga cactggaagt catgtgaacc ttggagcaat aacagccagt    120

ttgcaaaagg tggaaaatga tacatcccca caccgtgaaa gagccacttt gctggaggag    180

cagctgcccc tagggaaggc ctcgttccac atacctcaag tccaagtgag ggacgaagga    240

cagtaccaat gcataatcat ctatggggtc gcctgggact acaagtacct gactctgaaa    300

gtcaaagctt cctacaggaa aataaacact cacatcctaa aggttccaga aacagatgag    360

gtagagctca cctgccaggc tacaggttat cctctggcag aagtatcctg gccaaacgtc    420

agcgcgaaat ttgtggcggc gtggaccctg aaagcggcgg cggtcgacag cggcagcggc    480

atgtgtccag cgcgcagcct cctccttgtg gctaccctgg tcctcctgga ccacctcagt    540

ttggccagaa acctccccgt ggccactcca gacccaggaa tgttcccatg ccttcaccac    600

tcccaaaacc tgctgagggc cgtcagcaac atgctccaga aggccagaca aactctagaa    660

ttttaccctt gcacttctga agagattgat catgaagata tcacaaaaga taaaaccagc    720

acagtggagg cctgtttacc attggaatta accaagaatg agagttgcct aaattccaga    780

gagacctctt tcataactaa tgggagttgc ctggcctcca gaaagacctc ttttatgatg    840

gccctgtgcc ttagtagtat ttatgaagac ttgaagatgt accaggtgga gttcaagacc    900

atgaatgcaa agcttctgat ggatcctaag aggcagatct ttctagatca aaacatgctg    960

gcagttattg atgagctgat gcaggccctg aatttcaaca gtgagactgt gccacaaaaa   1020

tcctcccttg aagaaccgga tttttataaa actaaaatca agctctgcat acttcttcat   1080

gctttcagaa ttcgggcagt gactattgat agagtgatga gctatctgaa tgcttccggt   1140

ggcggtggct cgggcggtgg tgggtcgggt ggcggcggat ctatatggga actgaagaaa   1200

gatgtttatg tcgtagaatt ggattggtat ccggatgccc ctggagaaat ggtggtcctc   1260

acctgtgaca cccctgaaga agatggtatc acctggacct tggaccagag cagtgaggtc   1320

ttaggctctg gcaaaaccct gaccatccaa gtcaaagagt ttggagatgc tggccagtac   1380

acctgtcaca aaggaggcga ggttctaagc cattcgctcc tgctgcttca caaaaaggaa   1440

gatggaattt ggtccactga tattttaaag gaccagaaag aacccaaaaa taagaccttt   1500

ctaagatgcg aggccaagaa ttattctgga cgtttcacct gctggtggct gacgacaatc   1560

agtactgatt tgacattcag tgtcaaaagc agcagaggct cttctgaccc ccaaggggtg   1620

acgtgcggag ctgctacact ctctgcagag agagtcagag gggacaacaa ggagtatgag   1680

tactcagtgg agtgccagga ggacagtgcc tgcccagctg ctgaggagag tctgcccatt   1740

gaggtcatgg tggatgccgt tcacaagctc aagtatgaaa actacaccag cagcttcttc   1800

atcagggaca tcatcaaacc tgacccaccc aagaacttgc agctgaagcc attaaagaat   1860

tctcggcagg tggaggtcag ctgggagtac cctgacacct ggagtactcc acattcctac   1920

ttctccctga cattctgcgt tcaggtccag ggcaagagca agagagaaaa gaaagataga   1980

gtcttcacgg acaagacctc agccacggtc atctgccgca aaaatgccag cattagcgtg   2040

cgggcccagg accgctacta tagctcatct tggagcgaat gggcatctgt gccctgcagt   2100

ctcgagcacc accaccacca ccac                                          2124


<210>  16
<211>  1356
<212>  DNA
<213>  Artificial

<220>
<223>  PD-L1-PD-L2- PADRE 
       Th-GM-CSF鵰׵ĺĺ

<400>  16
atgtttactg tcacggttcc caaggaccta tatgtggtag agtatggtag caatatgaca     60

attgaatgca aattcccagt agaaaaacaa ttagacctgg ctgcactaat tgtctattgg    120

gaaatggagg ataagaacat tattcaattt gtgcatggag aggaagacct gaaggttcag    180

catagtagct acagacagag ggcccggctg ttgaaggacc agctctccct gggaaatgct    240

gcacttcaga tcacagatgt gaaattgcag gatgcagggg tgtaccgctg catgatcagc    300

tatggtggtg ccgactacaa gcgaattact gtgaaagtca atgccccata caacaaaatc    360

aaccaaagaa ttttggttgt ggatccagtc acctctgaac atgaactgac atgtcaggct    420

gagttattca cagtgacagt ccctaaggaa ctgtacataa tagagcatgg cagcaatgtg    480

accctggaat gcaactttga cactggaagt catgtgaacc ttggagcaat aacagccagt    540

ttgcaaaagg tggaaaatga tacatcccca caccgtgaaa gagccacttt gctggaggag    600

cagctgcccc tagggaaggc ctcgttccac atacctcaag tccaagtgag ggacgaagga    660

cagtaccaat gcataatcat ctatggggtc gcctgggact acaagtacct gactctgaaa    720

gtcaaagctt cctacaggaa aataaacact cacatcctaa aggttccaga aacagatgag    780

gtagagctca cctgccaggc tacaggttat cctctggcag aagtatcctg gccaaacgtc    840

agcgcgaaat ttgtggcggc gtggaccctg aaagcggcgg cggtcgacag cggcagcggc    900

atgtggctgc agagcctgct gctcttgggc actgtggcct gcagcatctc tgcacccgcc    960

cgctcgccca gccccagcac acagccctgg gagcatgtga atgccatcca ggaggcccgg   1020

cgtctcctga acctgagtag agacactgct gctgagatga atgaaacagt agaagtcatc   1080

tcagaaatgt ttgacctcca ggagccgacc tgcctacaga cccgcctgga gctgtacaag   1140

cagggcctgc ggggcagcct caccaagctc aagggcccct tgaccatgat ggccagccac   1200

tacaaacagc actgccctcc aaccccggaa acttcctgtg caacccagat tatcaccttt   1260

gaaagtttca aagagaacct gaaggacttt ctgcttgtca tcccctttga ctgctgggag   1320

ccagtccagg agctcgagca ccaccaccac caccac                             1356


<210>  17
<211>  1197
<212>  DNA
<213>  Artificial

<220>
<223>  PD-L1-PD-L2- PADRE Th- 
       RANTES鵰׵ĺĺ

<400>  17
atgtttactg tcacggttcc caaggaccta tatgtggtag agtatggtag caatatgaca     60

attgaatgca aattcccagt agaaaaacaa ttagacctgg ctgcactaat tgtctattgg    120

gaaatggagg ataagaacat tattcaattt gtgcatggag aggaagacct gaaggttcag    180

catagtagct acagacagag ggcccggctg ttgaaggacc agctctccct gggaaatgct    240

gcacttcaga tcacagatgt gaaattgcag gatgcagggg tgtaccgctg catgatcagc    300

tatggtggtg ccgactacaa gcgaattact gtgaaagtca atgccccata caacaaaatc    360

aaccaaagaa ttttggttgt ggatccagtc acctctgaac atgaactgac atgtcaggct    420

gagttattca cagtgacagt ccctaaggaa ctgtacataa tagagcatgg cagcaatgtg    480

accctggaat gcaactttga cactggaagt catgtgaacc ttggagcaat aacagccagt    540

ttgcaaaagg tggaaaatga tacatcccca caccgtgaaa gagccacttt gctggaggag    600

cagctgcccc tagggaaggc ctcgttccac atacctcaag tccaagtgag ggacgaagga    660

cagtaccaat gcataatcat ctatggggtc gcctgggact acaagtacct gactctgaaa    720

gtcaaagctt cctacaggaa aataaacact cacatcctaa aggttccaga aacagatgag    780

gtagagctca cctgccaggc tacaggttat cctctggcag aagtatcctg gccaaacgtc    840

agcgcgaaat ttgtggcggc gtggaccctg aaagcggcgg cggtcgacag cggcagcggc    900

atgaaggtct ccgcggcacg cctcgctgtc atcctcattg ctactgccct ctgcgctcct    960

gcatctgcct ccccatattc ctcggacacc acaccctgct gctttgccta cattgcccgc   1020

ccactgcccc gtgcccacat caaggagtat ttctacacca gtggcaagtg ctccaaccca   1080

gcagtcgtct ttgtcacccg aaagaaccgc caagtgtgtg ccaacccaga gaagaaatgg   1140

gttcgggagt acatcaactc tttggagatg agcctcgagc accaccacca ccaccac      1197


<210>  18
<211>  2544
<212>  DNA
<213>  Artificial

<220>
<223>  PD-L1-PD-L2- PADRE 
       Th-IL-12鵰׵ĺĺ

<400>  18
atgtttactg tcacggttcc caaggaccta tatgtggtag agtatggtag caatatgaca     60

attgaatgca aattcccagt agaaaaacaa ttagacctgg ctgcactaat tgtctattgg    120

gaaatggagg ataagaacat tattcaattt gtgcatggag aggaagacct gaaggttcag    180

catagtagct acagacagag ggcccggctg ttgaaggacc agctctccct gggaaatgct    240

gcacttcaga tcacagatgt gaaattgcag gatgcagggg tgtaccgctg catgatcagc    300

tatggtggtg ccgactacaa gcgaattact gtgaaagtca atgccccata caacaaaatc    360

aaccaaagaa ttttggttgt ggatccagtc acctctgaac atgaactgac atgtcaggct    420

gagttattca cagtgacagt ccctaaggaa ctgtacataa tagagcatgg cagcaatgtg    480

accctggaat gcaactttga cactggaagt catgtgaacc ttggagcaat aacagccagt    540

ttgcaaaagg tggaaaatga tacatcccca caccgtgaaa gagccacttt gctggaggag    600

cagctgcccc tagggaaggc ctcgttccac atacctcaag tccaagtgag ggacgaagga    660

cagtaccaat gcataatcat ctatggggtc gcctgggact acaagtacct gactctgaaa    720

gtcaaagctt cctacaggaa aataaacact cacatcctaa aggttccaga aacagatgag    780

gtagagctca cctgccaggc tacaggttat cctctggcag aagtatcctg gccaaacgtc    840

agcgcgaaat ttgtggcggc gtggaccctg aaagcggcgg cggtcgacag cggcagcggc    900

atgtgtccag cgcgcagcct cctccttgtg gctaccctgg tcctcctgga ccacctcagt    960

ttggccagaa acctccccgt ggccactcca gacccaggaa tgttcccatg ccttcaccac   1020

tcccaaaacc tgctgagggc cgtcagcaac atgctccaga aggccagaca aactctagaa   1080

ttttaccctt gcacttctga agagattgat catgaagata tcacaaaaga taaaaccagc   1140

acagtggagg cctgtttacc attggaatta accaagaatg agagttgcct aaattccaga   1200

gagacctctt tcataactaa tgggagttgc ctggcctcca gaaagacctc ttttatgatg   1260

gccctgtgcc ttagtagtat ttatgaagac ttgaagatgt accaggtgga gttcaagacc   1320

atgaatgcaa agcttctgat ggatcctaag aggcagatct ttctagatca aaacatgctg   1380

gcagttattg atgagctgat gcaggccctg aatttcaaca gtgagactgt gccacaaaaa   1440

tcctcccttg aagaaccgga tttttataaa actaaaatca agctctgcat acttcttcat   1500

gctttcagaa ttcgggcagt gactattgat agagtgatga gctatctgaa tgcttccggt   1560

ggcggtggct cgggcggtgg tgggtcgggt ggcggcggat ctatatggga actgaagaaa   1620

gatgtttatg tcgtagaatt ggattggtat ccggatgccc ctggagaaat ggtggtcctc   1680

acctgtgaca cccctgaaga agatggtatc acctggacct tggaccagag cagtgaggtc   1740

ttaggctctg gcaaaaccct gaccatccaa gtcaaagagt ttggagatgc tggccagtac   1800

acctgtcaca aaggaggcga ggttctaagc cattcgctcc tgctgcttca caaaaaggaa   1860

gatggaattt ggtccactga tattttaaag gaccagaaag aacccaaaaa taagaccttt   1920

ctaagatgcg aggccaagaa ttattctgga cgtttcacct gctggtggct gacgacaatc   1980

agtactgatt tgacattcag tgtcaaaagc agcagaggct cttctgaccc ccaaggggtg   2040

acgtgcggag ctgctacact ctctgcagag agagtcagag gggacaacaa ggagtatgag   2100

tactcagtgg agtgccagga ggacagtgcc tgcccagctg ctgaggagag tctgcccatt   2160

gaggtcatgg tggatgccgt tcacaagctc aagtatgaaa actacaccag cagcttcttc   2220

atcagggaca tcatcaaacc tgacccaccc aagaacttgc agctgaagcc attaaagaat   2280

tctcggcagg tggaggtcag ctgggagtac cctgacacct ggagtactcc acattcctac   2340

ttctccctga cattctgcgt tcaggtccag ggcaagagca agagagaaaa gaaagataga   2400

gtcttcacgg acaagacctc agccacggtc atctgccgca aaaatgccag cattagcgtg   2460

cgggcccagg accgctacta tagctcatct tggagcgaat gggcatctgt gccctgcagt   2520

ctcgagcacc accaccacca ccac                                          2544


<210>  19
<211>  201
<212>  PRT
<213>  Artificial

<220>
<223>  PD-L1İ

<400>  19

Met Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly 
1               5                   10                  15      


Ser Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp 
            20                  25                  30          


Leu Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile 
        35                  40                  45              


Gln Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr 
    50                  55                  60                  


Arg Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala 
65                  70                  75                  80  


Ala Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg 
                85                  90                  95      


Cys Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys 
            100                 105                 110         


Val Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp 
        115                 120                 125             


Pro Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro 
    130                 135                 140                 


Lys Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly 
145                 150                 155                 160 


Lys Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val 
                165                 170                 175     


Thr Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys 
            180                 185                 190         


Thr Phe Arg Arg Leu Asp Pro Glu Glu 
        195                 200     


<210>  20
<211>  141
<212>  PRT
<213>  Artificial

<220>
<223>  PD-L2İ

<400>  20

Met Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu His 
1               5                   10                  15      


Gly Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val 
            20                  25                  30          


Asn Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr 
        35                  40                  45              


Ser Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu 
    50                  55                  60                  


Gly Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly 
65                  70                  75                  80  


Gln Tyr Gln Cys Ile Ile Ile Tyr Gly Val Ala Trp Asp Tyr Lys Tyr 
                85                  90                  95      


Leu Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile 
            100                 105                 110         


Leu Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr 
        115                 120                 125             


Gly Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser 
    130                 135                 140     


<210>  21
<211>  281
<212>  PRT
<213>  Artificial

<220>
<223>  PD-L1-PD-L2İ

<400>  21

Met Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly 
1               5                   10                  15      


Ser Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp 
            20                  25                  30          


Leu Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile 
        35                  40                  45              


Gln Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr 
    50                  55                  60                  


Arg Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala 
65                  70                  75                  80  


Ala Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg 
                85                  90                  95      


Cys Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys 
            100                 105                 110         


Val Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp 
        115                 120                 125             


Pro Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Leu Phe Thr 
    130                 135                 140                 


Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu His Gly Ser Asn Val 
145                 150                 155                 160 


Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn Leu Gly Ala 
                165                 170                 175     


Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser Pro His Arg 
            180                 185                 190         


Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly Lys Ala Ser 
        195                 200                 205             


Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln Tyr Gln Cys 
    210                 215                 220                 


Ile Ile Ile Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu Thr Leu Lys 
225                 230                 235                 240 


Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu Lys Val Pro 
                245                 250                 255     


Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly Tyr Pro Leu 
            260                 265                 270         


Ala Glu Val Ser Trp Pro Asn Val Ser 
        275                 280     


<210>  22
<211>  603
<212>  DNA
<213>  Artificial

<220>
<223>  PD-L1ĺӵĺ

<400>  22
atgtttactg tcacggttcc caaggaccta tatgtggtag agtatggtag caatatgaca     60

attgaatgca aattcccagt agaaaaacaa ttagacctgg ctgcactaat tgtctattgg    120

gaaatggagg ataagaacat tattcaattt gtgcatggag aggaagacct gaaggttcag    180

catagtagct acagacagag ggcccggctg ttgaaggacc agctctccct gggaaatgct    240

gcacttcaga tcacagatgt gaaattgcag gatgcagggg tgtaccgctg catgatcagc    300

tatggtggtg ccgactacaa gcgaattact gtgaaagtca atgccccata caacaaaatc    360

aaccaaagaa ttttggttgt ggatccagtc acctctgaac atgaactgac atgtcaggct    420

gagggctacc ccaaggccga agtcatctgg acaagcagtg accatcaagt cctgagtggt    480

aagaccacca ccaccaattc caagagagag gagaagcttt tcaatgtgac cagcacactg    540

agaatcaaca caacaactaa tgagattttc tactgcactt ttaggagatt agatcctgag    600

gaa                                                                  603


<210>  23
<211>  423
<212>  DNA
<213>  Artificial

<220>
<223>  PD-L2ĺӵĺ

<400>  23
atgttattca cagtgacagt ccctaaggaa ctgtacataa tagagcatgg cagcaatgtg     60

accctggaat gcaactttga cactggaagt catgtgaacc ttggagcaat aacagccagt    120

ttgcaaaagg tggaaaatga tacatcccca caccgtgaaa gagccacttt gctggaggag    180

cagctgcccc tagggaaggc ctcgttccac atacctcaag tccaagtgag ggacgaagga    240

cagtaccaat gcataatcat ctatggggtc gcctgggact acaagtacct gactctgaaa    300

gtcaaagctt cctacaggaa aataaacact cacatcctaa aggttccaga aacagatgag    360

gtagagctca cctgccaggc tacaggttat cctctggcag aagtatcctg gccaaacgtc    420

agc                                                                  423


<210>  24
<211>  843
<212>  DNA
<213>  Artificial

<220>
<223>  PD-L1-PD-L2ĺӵĺ

<400>  24
atgtttactg tcacggttcc caaggaccta tatgtggtag agtatggtag caatatgaca     60

attgaatgca aattcccagt agaaaaacaa ttagacctgg ctgcactaat tgtctattgg    120

gaaatggagg ataagaacat tattcaattt gtgcatggag aggaagacct gaaggttcag    180

catagtagct acagacagag ggcccggctg ttgaaggacc agctctccct gggaaatgct    240

gcacttcaga tcacagatgt gaaattgcag gatgcagggg tgtaccgctg catgatcagc    300

tatggtggtg ccgactacaa gcgaattact gtgaaagtca atgccccata caacaaaatc    360

aaccaaagaa ttttggttgt ggatccagtc acctctgaac atgaactgac atgtcaggct    420

gagttattca cagtgacagt ccctaaggaa ctgtacataa tagagcatgg cagcaatgtg    480

accctggaat gcaactttga cactggaagt catgtgaacc ttggagcaat aacagccagt    540

ttgcaaaagg tggaaaatga tacatcccca caccgtgaaa gagccacttt gctggaggag    600

cagctgcccc tagggaaggc ctcgttccac atacctcaag tccaagtgag ggacgaagga    660

cagtaccaat gcataatcat ctatggggtc gcctgggact acaagtacct gactctgaaa    720

gtcaaagctt cctacaggaa aataaacact cacatcctaa aggttccaga aacagatgag    780

gtagagctca cctgccaggc tacaggttat cctctggcag aagtatcctg gccaaacgtc    840

agc                                                                  843


<210>  25
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  TϸԭƬεİ

<400>  25

Ala Lys Phe Val Ala Ala Trp Thr Leu Lys Ala Ala Ala 
1               5                   10              


<210>  26
<211>  39
<212>  DNA
<213>  Artificial

<220>
<223>  븨TϸԭƬεĺӵĺ

<400>  26
gcgaaatttg tggcggcgtg gaccctgaaa gcggcggcg                            39


<210>  27
<211>  144
<212>  PRT
<213>  Artificial

<220>
<223>  GM-CSFƬεİ

<400>  27

Met Trp Leu Gln Ser Leu Leu Leu Leu Gly Thr Val Ala Cys Ser Ile 
1               5                   10                  15      


Ser Ala Pro Ala Arg Ser Pro Ser Pro Ser Thr Gln Pro Trp Glu His 
            20                  25                  30          


Val Asn Ala Ile Gln Glu Ala Arg Arg Leu Leu Asn Leu Ser Arg Asp 
        35                  40                  45              


Thr Ala Ala Glu Met Asn Glu Thr Val Glu Val Ile Ser Glu Met Phe 
    50                  55                  60                  


Asp Leu Gln Glu Pro Thr Cys Leu Gln Thr Arg Leu Glu Leu Tyr Lys 
65                  70                  75                  80  


Gln Gly Leu Arg Gly Ser Leu Thr Lys Leu Lys Gly Pro Leu Thr Met 
                85                  90                  95      


Met Ala Ser His Tyr Lys Gln His Cys Pro Pro Thr Pro Glu Thr Ser 
            100                 105                 110         


Cys Ala Thr Gln Ile Ile Thr Phe Glu Ser Phe Lys Glu Asn Leu Lys 
        115                 120                 125             


Asp Phe Leu Leu Val Ile Pro Phe Asp Cys Trp Glu Pro Val Gln Glu 
    130                 135                 140                 


<210>  28
<211>  91
<212>  PRT
<213>  Artificial

<220>
<223>  RANTESƬεİ

<400>  28

Met Lys Val Ser Ala Ala Arg Leu Ala Val Ile Leu Ile Ala Thr Ala 
1               5                   10                  15      


Leu Cys Ala Pro Ala Ser Ala Ser Pro Tyr Ser Ser Asp Thr Thr Pro 
            20                  25                  30          


Cys Cys Phe Ala Tyr Ile Ala Arg Pro Leu Pro Arg Ala His Ile Lys 
        35                  40                  45              


Glu Tyr Phe Tyr Thr Ser Gly Lys Cys Ser Asn Pro Ala Val Val Phe 
    50                  55                  60                  


Val Thr Arg Lys Asn Arg Gln Val Cys Ala Asn Pro Glu Lys Lys Trp 
65                  70                  75                  80  


Val Arg Glu Tyr Ile Asn Ser Leu Glu Met Ser 
                85                  90      


<210>  29
<211>  540
<212>  PRT
<213>  Artificial

<220>
<223>  IL-12Ƭεİ

<400>  29

Met Cys Pro Ala Arg Ser Leu Leu Leu Val Ala Thr Leu Val Leu Leu 
1               5                   10                  15      


Asp His Leu Ser Leu Ala Arg Asn Leu Pro Val Ala Thr Pro Asp Pro 
            20                  25                  30          


Gly Met Phe Pro Cys Leu His His Ser Gln Asn Leu Leu Arg Ala Val 
        35                  40                  45              


Ser Asn Met Leu Gln Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys 
    50                  55                  60                  


Thr Ser Glu Glu Ile Asp His Glu Asp Ile Thr Lys Asp Lys Thr Ser 
65                  70                  75                  80  


Thr Val Glu Ala Cys Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys 
                85                  90                  95      


Leu Asn Ser Arg Glu Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala 
            100                 105                 110         


Ser Arg Lys Thr Ser Phe Met Met Ala Leu Cys Leu Ser Ser Ile Tyr 
        115                 120                 125             


Glu Asp Leu Lys Met Tyr Gln Val Glu Phe Lys Thr Met Asn Ala Lys 
    130                 135                 140                 


Leu Leu Met Asp Pro Lys Arg Gln Ile Phe Leu Asp Gln Asn Met Leu 
145                 150                 155                 160 


Ala Val Ile Asp Glu Leu Met Gln Ala Leu Asn Phe Asn Ser Glu Thr 
                165                 170                 175     


Val Pro Gln Lys Ser Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys 
            180                 185                 190         


Ile Lys Leu Cys Ile Leu Leu His Ala Phe Arg Ile Arg Ala Val Thr 
        195                 200                 205             


Ile Asp Arg Val Met Ser Tyr Leu Asn Ala Ser Gly Gly Gly Gly Ser 
    210                 215                 220                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ile Trp Glu Leu Lys Lys 
225                 230                 235                 240 


Asp Val Tyr Val Val Glu Leu Asp Trp Tyr Pro Asp Ala Pro Gly Glu 
                245                 250                 255     


Met Val Val Leu Thr Cys Asp Thr Pro Glu Glu Asp Gly Ile Thr Trp 
            260                 265                 270         


Thr Leu Asp Gln Ser Ser Glu Val Leu Gly Ser Gly Lys Thr Leu Thr 
        275                 280                 285             


Ile Gln Val Lys Glu Phe Gly Asp Ala Gly Gln Tyr Thr Cys His Lys 
    290                 295                 300                 


Gly Gly Glu Val Leu Ser His Ser Leu Leu Leu Leu His Lys Lys Glu 
305                 310                 315                 320 


Asp Gly Ile Trp Ser Thr Asp Ile Leu Lys Asp Gln Lys Glu Pro Lys 
                325                 330                 335     


Asn Lys Thr Phe Leu Arg Cys Glu Ala Lys Asn Tyr Ser Gly Arg Phe 
            340                 345                 350         


Thr Cys Trp Trp Leu Thr Thr Ile Ser Thr Asp Leu Thr Phe Ser Val 
        355                 360                 365             


Lys Ser Ser Arg Gly Ser Ser Asp Pro Gln Gly Val Thr Cys Gly Ala 
    370                 375                 380                 


Ala Thr Leu Ser Ala Glu Arg Val Arg Gly Asp Asn Lys Glu Tyr Glu 
385                 390                 395                 400 


Tyr Ser Val Glu Cys Gln Glu Asp Ser Ala Cys Pro Ala Ala Glu Glu 
                405                 410                 415     


Ser Leu Pro Ile Glu Val Met Val Asp Ala Val His Lys Leu Lys Tyr 
            420                 425                 430         


Glu Asn Tyr Thr Ser Ser Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp 
        435                 440                 445             


Pro Pro Lys Asn Leu Gln Leu Lys Pro Leu Lys Asn Ser Arg Gln Val 
    450                 455                 460                 


Glu Val Ser Trp Glu Tyr Pro Asp Thr Trp Ser Thr Pro His Ser Tyr 
465                 470                 475                 480 


Phe Ser Leu Thr Phe Cys Val Gln Val Gln Gly Lys Ser Lys Arg Glu 
                485                 490                 495     


Lys Lys Asp Arg Val Phe Thr Asp Lys Thr Ser Ala Thr Val Ile Cys 
            500                 505                 510         


Arg Lys Asn Ala Ser Ile Ser Val Arg Ala Gln Asp Arg Tyr Tyr Ser 
        515                 520                 525             


Ser Ser Trp Ser Glu Trp Ala Ser Val Pro Cys Ser 
    530                 535                 540 


<210>  30
<211>  432
<212>  DNA
<213>  Artificial

<220>
<223>  GM-CSFƬεĺӵĺ

<400>  30
atgtggctgc agagcctgct gctcttgggc actgtggcct gcagcatctc tgcacccgcc     60

cgctcgccca gccccagcac acagccctgg gagcatgtga atgccatcca ggaggcccgg    120

cgtctcctga acctgagtag agacactgct gctgagatga atgaaacagt agaagtcatc    180

tcagaaatgt ttgacctcca ggagccgacc tgcctacaga cccgcctgga gctgtacaag    240

cagggcctgc ggggcagcct caccaagctc aagggcccct tgaccatgat ggccagccac    300

tacaaacagc actgccctcc aaccccggaa acttcctgtg caacccagat tatcaccttt    360

gaaagtttca aagagaacct gaaggacttt ctgcttgtca tcccctttga ctgctgggag    420

ccagtccagg ag                                                        432


<210>  31
<211>  273
<212>  DNA
<213>  Artificial

<220>
<223>  RANTESƬεĺӵĺ

<400>  31
atgaaggtct ccgcggcacg cctcgctgtc atcctcattg ctactgccct ctgcgctcct     60

gcatctgcct ccccatattc ctcggacacc acaccctgct gctttgccta cattgcccgc    120

ccactgcccc gtgcccacat caaggagtat ttctacacca gtggcaagtg ctccaaccca    180

gcagtcgtct ttgtcacccg aaagaaccgc caagtgtgtg ccaacccaga gaagaaatgg    240

gttcgggagt acatcaactc tttggagatg agc                                 273


<210>  32
<211>  1620
<212>  DNA
<213>  Artificial

<220>
<223>  IL-12Ƭεĺӵĺ

<400>  32
atgtgtccag cgcgcagcct cctccttgtg gctaccctgg tcctcctgga ccacctcagt     60

ttggccagaa acctccccgt ggccactcca gacccaggaa tgttcccatg ccttcaccac    120

tcccaaaacc tgctgagggc cgtcagcaac atgctccaga aggccagaca aactctagaa    180

ttttaccctt gcacttctga agagattgat catgaagata tcacaaaaga taaaaccagc    240

acagtggagg cctgtttacc attggaatta accaagaatg agagttgcct aaattccaga    300

gagacctctt tcataactaa tgggagttgc ctggcctcca gaaagacctc ttttatgatg    360

gccctgtgcc ttagtagtat ttatgaagac ttgaagatgt accaggtgga gttcaagacc    420

atgaatgcaa agcttctgat ggatcctaag aggcagatct ttctagatca aaacatgctg    480

gcagttattg atgagctgat gcaggccctg aatttcaaca gtgagactgt gccacaaaaa    540

tcctcccttg aagaaccgga tttttataaa actaaaatca agctctgcat acttcttcat    600

gctttcagaa ttcgggcagt gactattgat agagtgatga gctatctgaa tgcttccggt    660

ggcggtggct cgggcggtgg tgggtcgggt ggcggcggat ctatatggga actgaagaaa    720

gatgtttatg tcgtagaatt ggattggtat ccggatgccc ctggagaaat ggtggtcctc    780

acctgtgaca cccctgaaga agatggtatc acctggacct tggaccagag cagtgaggtc    840

ttaggctctg gcaaaaccct gaccatccaa gtcaaagagt ttggagatgc tggccagtac    900

acctgtcaca aaggaggcga ggttctaagc cattcgctcc tgctgcttca caaaaaggaa    960

gatggaattt ggtccactga tattttaaag gaccagaaag aacccaaaaa taagaccttt   1020

ctaagatgcg aggccaagaa ttattctgga cgtttcacct gctggtggct gacgacaatc   1080

agtactgatt tgacattcag tgtcaaaagc agcagaggct cttctgaccc ccaaggggtg   1140

acgtgcggag ctgctacact ctctgcagag agagtcagag gggacaacaa ggagtatgag   1200

tactcagtgg agtgccagga ggacagtgcc tgcccagctg ctgaggagag tctgcccatt   1260

gaggtcatgg tggatgccgt tcacaagctc aagtatgaaa actacaccag cagcttcttc   1320

atcagggaca tcatcaaacc tgacccaccc aagaacttgc agctgaagcc attaaagaat   1380

tctcggcagg tggaggtcag ctgggagtac cctgacacct ggagtactcc acattcctac   1440

ttctccctga cattctgcgt tcaggtccag ggcaagagca agagagaaaa gaaagataga   1500

gtcttcacgg acaagacctc agccacggtc atctgccgca aaaatgccag cattagcgtg   1560

cgggcccagg accgctacta tagctcatct tggagcgaat gggcatctgt gccctgcagt   1620


