SEQUENCE LISTING

<110>  ʡũҵѧԺ
<120>  һALSͻͻڿݼӦ
<130>  SG20160329001
<160>8
<170>  PatentIn version 3.3
<210>  1
<211>  1935
<212>  DNA
<213>  ALSͻͻ
<220>
<221>  CDS
<222>  (1)..(1935)
<400>  1
atg gct acg acc gcc gcg gcc gcg gcc gcc acc ttg tcc gcc gcc gcg       48
Met Ala Thr Thr Ala Ala Ala Ala Ala Ala Thr Leu Ser Ala Ala Ala         
1               5                   10                  15              
acg gcc aag acc ggc cgt aag aac cac cag cga cac cac gtc ttt ccc       96
Thr Ala Lys Thr Gly Arg Lys Asn His Gln Arg His His Val Phe Pro         
            20                  25                  30                  
gct cga ggc cgg gtg ggg gcg gcg gcg gtc agg tgc tcg gcg gtg tcc      144
Ala Arg Gly Arg Val Gly Ala Ala Ala Val Arg Cys Ser Ala Val Ser         
        35                  40                  45                      
ccg gtc acc ccg ccg tcc ccg gcg ccg ccg gcc acg ccg ctc cgg ccg      192
Pro Val Thr Pro Pro Ser Pro Ala Pro Pro Ala Thr Pro Leu Arg Pro         
    50                  55                  60                          
tgg ggg ccg gcc gag ccc cgc aag ggc gcg gac atc ctc gtg gag gcg      240
Trp Gly Pro Ala Glu Pro Arg Lys Gly Ala Asp Ile Leu Val Glu Ala         
65                  70                  75                  80          
ctg gag cgg tgc ggc gtc agc gac gtg ttc gcc tac ccg ggc ggc gcg      288
Leu Glu Arg Cys Gly Val Ser Asp Val Phe Ala Tyr Pro Gly Gly Ala         
                85                  90                  95              
tcc atg gag atc cac cag gcg ctg acg cgc tcc ccg gtc atc acc aac      336
Ser Met Glu Ile His Gln Ala Leu Thr Arg Ser Pro Val Ile Thr Asn         
            100                 105                 110                 
cac ctc ttc cgc cac gag cag ggc gag gcg ttc gcg gcg tcc ggg tac      384
His Leu Phe Arg His Glu Gln Gly Glu Ala Phe Ala Ala Ser Gly Tyr         
        115                 120                 125                     
gcg cgc gcg tcc ggc cgc gtc ggg gtc tgc gtc gcc acc tcc ggc ccc      432
Ala Arg Ala Ser Gly Arg Val Gly Val Cys Val Ala Thr Ser Gly Pro         
    130                 135                 140                         
ggg gca acc aac ctc gtg tcc gcg ctc gcc gac gcg ctg ctc gac tcc      480
Gly Ala Thr Asn Leu Val Ser Ala Leu Ala Asp Ala Leu Leu Asp Ser         
145                 150                 155                 160         
gtc ccg atg gtc gcc atc acg ggc cag gtc ccc cgc cgc atg atc ggc      528
Val Pro Met Val Ala Ile Thr Gly Gln Val Pro Arg Arg Met Ile Gly         
                165                 170                 175             
acc gac gcc ttc cag gag acg ccc ata gtc gag gtc acc cgc tcc atc      576
Thr Asp Ala Phe Gln Glu Thr Pro Ile Val Glu Val Thr Arg Ser Ile         
            180                 185                 190                 
acc aag cac aat tac ctt gtc ctt gat gtg gag gac atc ccc cgc gtc      624
Thr Lys His Asn Tyr Leu Val Leu Asp Val Glu Asp Ile Pro Arg Val         
        195                 200                 205                     
ata cag gaa gcc ttc ttc ctc gcg tcc tcg ggc cgt cct ggc ccg gtg      672
Ile Gln Glu Ala Phe Phe Leu Ala Ser Ser Gly Arg Pro Gly Pro Val         
    210                 215                 220                         
ctg gtc gac atc ccc aag gac atc cag cag cag atg gct gtg cca gtc      720
Leu Val Asp Ile Pro Lys Asp Ile Gln Gln Gln Met Ala Val Pro Val         
225                 230                 235                 240         
tgg gac acc tcg atg aat cta ccg ggg tac att gca cgc ctg ccc aag      768
Trp Asp Thr Ser Met Asn Leu Pro Gly Tyr Ile Ala Arg Leu Pro Lys         
                245                 250                 255             
cca ccc gcg aca gaa ttg ctt gag cag gtc ttg cgt ctg gtt ggc gag      816
Pro Pro Ala Thr Glu Leu Leu Glu Gln Val Leu Arg Leu Val Gly Glu         
            260                 265                 270                 
tca cgg cgc ccg att ctc tat gtc ggt ggt ggc tgc tct gca tct ggt      864
Ser Arg Arg Pro Ile Leu Tyr Val Gly Gly Gly Cys Ser Ala Ser Gly         
        275                 280                 285                     
gat gaa ttg cgc cgg ttt gtt gag ctg acc ggc atc cca gtt aca acc      912
Asp Glu Leu Arg Arg Phe Val Glu Leu Thr Gly Ile Pro Val Thr Thr         
    290                 295                 300                         
act ctg atg ggc ctc ggc aat ttc ccc agt gat gat ccg ttg tcc ctg      960
Thr Leu Met Gly Leu Gly Asn Phe Pro Ser Asp Asp Pro Leu Ser Leu         
305                 310                 315                 320         
cgc atg ctt ggg atg cat ggc acg gtg tac gca aat tat gcg gtg gat     1008
Arg Met Leu Gly Met His Gly Thr Val Tyr Ala Asn Tyr Ala Val Asp         
                325                 330                 335           
aag gct gac ctg ttg ctt gca ttt ggc gtg cgg ttt gat gat cgt gtg     1056
Lys Ala Asp Leu Leu Leu Ala Phe Gly Val Arg Phe Asp Asp Arg Val         
            340                 345                 350                 
aca ggg aaa att gag gct ttt gca agc agg gcc aag att gtg cac att     1104
Thr Gly Lys Ile Glu Ala Phe Ala Ser Arg Ala Lys Ile Val His Ile         
        355                 360                 365                     
gac att gat cca gcg gag att gga aag aac aag caa cca cat gtg tca     1152
Asp Ile Asp Pro Ala Glu Ile Gly Lys Asn Lys Gln Pro His Val Ser         
    370                 375                 380                         
att tgc gca gat gtt aag ctt gct tta cag ggc ttg aat gct ctg cta     1200
Ile Cys Ala Asp Val Lys Leu Ala Leu Gln Gly Leu Asn Ala Leu Leu         
385                 390                 395                 400         
gac cag agc aca aca aag aca agt tct gat ttt agt gcg tgg cac aat     1248
Asp Gln Ser Thr Thr Lys Thr Ser Ser Asp Phe Ser Ala Trp His Asn         
                405                 410                 415             
gag ttg gac cag cag aag agg gag ttt cct ctg ggg tac aag act ttt     1296
Glu Leu Asp Gln Gln Lys Arg Glu Phe Pro Leu Gly Tyr Lys Thr Phe         
            420                 425                 430                 
ggt gaa gag atc cca ccg caa tat gct att cag gtg ctg gat gag ctg     1344
Gly Glu Glu Ile Pro Pro Gln Tyr Ala Ile Gln Val Leu Asp Glu Leu         
        435                 440                 445                     
acg aaa ggg gag gca atc atc gct act ggt gtt gga cag cac cag atg     1392
Thr Lys Gly Glu Ala Ile Ile Ala Thr Gly Val Gly Gln His Gln Met         
    450                 455                 460                         
tgg gcg gca caa tat tac acc tac aag cgg cca cgg cag tgg ctg tct     1440
Trp Ala Ala Gln Tyr Tyr Thr Tyr Lys Arg Pro Arg Gln Trp Leu Ser         
465                 470                 475                 480         
tcg gct ggt ctg ggc gca atg gga ttt ggg ctg cct gct gca gct ggt     1488
Ser Ala Gly Leu Gly Ala Met Gly Phe Gly Leu Pro Ala Ala Ala Gly         
                485                 490                 495             
gct tct gtg gct aac cca ggt gtc aca gtt gtt gat att gat ggg gat     1536
Ala Ser Val Ala Asn Pro Gly Val Thr Val Val Asp Ile Asp Gly Asp         
            500                 505                 510                 
ggt agc ttc ctc atg aac att cag gag ttg gca ttg atc cgc att gag     1584
Gly Ser Phe Leu Met Asn Ile Gln Glu Leu Ala Leu Ile Arg Ile Glu         
        515                 520                 525                     
aac ctc ccg gtg aag gtg atg gtg ttg aac aac caa cat ttg ggt atg     1632
Asn Leu Pro Val Lys Val Met Val Leu Asn Asn Gln His Leu Gly Met         
    530                 535                 540                         
gtt gtg caa tgg gag gat agg ttt tac aag gca aat agg gcg cat aca     1680
Val Val Gln Trp Glu Asp Arg Phe Tyr Lys Ala Asn Arg Ala His Thr         
545                 550                 555                 560         
tac ttg ggc aac cca gaa tgt gag agt gag ata tat cca gat ttt gtg     1728
Tyr Leu Gly Asn Pro Glu Cys Glu Ser Glu Ile Tyr Pro Asp Phe Val         
                565                 570                 575             
act att gct aaa ggg ttc aat att cct gca gtc cgt gta aca aag aag     1776
Thr Ile Ala Lys Gly Phe Asn Ile Pro Ala Val Arg Val Thr Lys Lys         
            580                 585                 590                 
agt gaa gtc cgt gcc gcc atc aag aag atg ctc gat acc cca ggg cca     1824
Ser Glu Val Arg Ala Ala Ile Lys Lys Met Leu Asp Thr Pro Gly Pro         
        595                 600                 605                     
tac ttg ttg gat atc atc gtc cca cac cag gag cat gtg ctg cct atg     1872
Tyr Leu Leu Asp Ile Ile Val Pro His Gln Glu His Val Leu Pro Met         
    610                 615                 620                         
atc cca agt ggg ggc gca ttc aag gac atg atc ctg gat ggt gat ggc     1920
Ile Pro Ser Gly Gly Ala Phe Lys Asp Met Ile Leu Asp Gly Asp Gly         
625                 630                 635                 640         
agg act gtg tat taa                                                 1935
Arg Thr Val Tyr                                                         

<210>  2
<211>  644
<212>  PRT
<213>  ALSͻͻ
<400>  2
Met Ala Thr Thr Ala Ala Ala Ala Ala Ala Thr Leu Ser Ala Ala Ala 
1               5                   10                  15      
Thr Ala Lys Thr Gly Arg Lys Asn His Gln Arg His His Val Phe Pro 
            20                  25                  30          
Ala Arg Gly Arg Val Gly Ala Ala Ala Val Arg Cys Ser Ala Val Ser 
        35                  40                  45              
Pro Val Thr Pro Pro Ser Pro Ala Pro Pro Ala Thr Pro Leu Arg Pro 
    50                  55                  60                  
Trp Gly Pro Ala Glu Pro Arg Lys Gly Ala Asp Ile Leu Val Glu Ala 
65                  70                  75                  80  
Leu Glu Arg Cys Gly Val Ser Asp Val Phe Ala Tyr Pro Gly Gly Ala 
                85                  90                  95      
Ser Met Glu Ile His Gln Ala Leu Thr Arg Ser Pro Val Ile Thr Asn 
            100                 105                 110         
His Leu Phe Arg His Glu Gln Gly Glu Ala Phe Ala Ala Ser Gly Tyr 
        115                 120                 125             
Ala Arg Ala Ser Gly Arg Val Gly Val Cys Val Ala Thr Ser Gly Pro 
    130                 135                 140                 
Gly Ala Thr Asn Leu Val Ser Ala Leu Ala Asp Ala Leu Leu Asp Ser 
145                 150                 155                 160 
Val Pro Met Val Ala Ile Thr Gly Gln Val Pro Arg Arg Met Ile Gly 
                165                 170                 175     
Thr Asp Ala Phe Gln Glu Thr Pro Ile Val Glu Val Thr Arg Ser Ile 
            180                 185                 190         
Thr Lys His Asn Tyr Leu Val Leu Asp Val Glu Asp Ile Pro Arg Val 
        195                 200                 205             
Ile Gln Glu Ala Phe Phe Leu Ala Ser Ser Gly Arg Pro Gly Pro Val 
    210                 215                 220                 
Leu Val Asp Ile Pro Lys Asp Ile Gln Gln Gln Met Ala Val Pro Val 
225                 230                 235                 240 
Trp Asp Thr Ser Met Asn Leu Pro Gly Tyr Ile Ala Arg Leu Pro Lys 
                245                 250                 255     
Pro Pro Ala Thr Glu Leu Leu Glu Gln Val Leu Arg Leu Val Gly Glu 
            260                 265                 270         
Ser Arg Arg Pro Ile Leu Tyr Val Gly Gly Gly Cys Ser Ala Ser Gly 
        275                 280                 285             
Asp Glu Leu Arg Arg Phe Val Glu Leu Thr Gly Ile Pro Val Thr Thr 
    290                 295                 300                 
Thr Leu Met Gly Leu Gly Asn Phe Pro Ser Asp Asp Pro Leu Ser Leu 
305                 310                 315                 320 
Arg Met Leu Gly Met His Gly Thr Val Tyr Ala Asn Tyr Ala Val Asp 
                325                 330                 335     
Lys Ala Asp Leu Leu Leu Ala Phe Gly Val Arg Phe Asp Asp Arg Val 
            340                 345                 350         
Thr Gly Lys Ile Glu Ala Phe Ala Ser Arg Ala Lys Ile Val His Ile 
        355                 360                 365             
Asp Ile Asp Pro Ala Glu Ile Gly Lys Asn Lys Gln Pro His Val Ser 
    370                 375                 380                 
Ile Cys Ala Asp Val Lys Leu Ala Leu Gln Gly Leu Asn Ala Leu Leu 
385                 390                 395                 400 
Asp Gln Ser Thr Thr Lys Thr Ser Ser Asp Phe Ser Ala Trp His Asn 
                405                 410                 415     
Glu Leu Asp Gln Gln Lys Arg Glu Phe Pro Leu Gly Tyr Lys Thr Phe 
            420                 425                 430         
Gly Glu Glu Ile Pro Pro Gln Tyr Ala Ile Gln Val Leu Asp Glu Leu 
        435                 440                 445             
Thr Lys Gly Glu Ala Ile Ile Ala Thr Gly Val Gly Gln His Gln Met 
    450                 455                 460                 
Trp Ala Ala Gln Tyr Tyr Thr Tyr Lys Arg Pro Arg Gln Trp Leu Ser 
465                 470                 475                 480 
Ser Ala Gly Leu Gly Ala Met Gly Phe Gly Leu Pro Ala Ala Ala Gly 
                485                 490                 495     
Ala Ser Val Ala Asn Pro Gly Val Thr Val Val Asp Ile Asp Gly Asp 
            500                 505                 510         
Gly Ser Phe Leu Met Asn Ile Gln Glu Leu Ala Leu Ile Arg Ile Glu 
        515                 520                 525             
Asn Leu Pro Val Lys Val Met Val Leu Asn Asn Gln His Leu Gly Met 
    530                 535                 540                 
Val Val Gln Trp Glu Asp Arg Phe Tyr Lys Ala Asn Arg Ala His Thr 
545                 550                 555                 560 
Tyr Leu Gly Asn Pro Glu Cys Glu Ser Glu Ile Tyr Pro Asp Phe Val 
                565                 570                 575     
Thr Ile Ala Lys Gly Phe Asn Ile Pro Ala Val Arg Val Thr Lys Lys 
            580                 585                 590         
Ser Glu Val Arg Ala Ala Ile Lys Lys Met Leu Asp Thr Pro Gly Pro 
        595                 600                 605             
Tyr Leu Leu Asp Ile Ile Val Pro His Gln Glu His Val Leu Pro Met 
    610                 615                 620                 
Ile Pro Ser Gly Gly Ala Phe Lys Asp Met Ile Leu Asp Gly Asp Gly 
625                 630                 635                 640 
Arg Thr Val Tyr 

<210>  3
<211>  1935
<212>  DNA
<213>  ALSͻͻ
<220>
<221>  CDS
<222>  (1)..(1935)
<400>  3
atg gct acg acc gcc gcg gcc gcg gcc gcc acc ttg tcc gcc gcc gcg       48
Met Ala Thr Thr Ala Ala Ala Ala Ala Ala Thr Leu Ser Ala Ala Ala         
1               5                   10                  15              
acg gcc aag acc ggc cgt aag aac cac cag cga cac cac gtc ttt ccc       96
Thr Ala Lys Thr Gly Arg Lys Asn His Gln Arg His His Val Phe Pro         
            20                  25                  30                  
gct cga ggc cgg gtg ggg gcg gcg gcg gtc agg tgc tcg gcg gtg tcc      144
Ala Arg Gly Arg Val Gly Ala Ala Ala Val Arg Cys Ser Ala Val Ser         
        35                  40                  45                      
ccg gtc acc ccg ccg tcc ccg gcg ccg ccg gcc acg ccg ctc cgg ccg      192
Pro Val Thr Pro Pro Ser Pro Ala Pro Pro Ala Thr Pro Leu Arg Pro         
    50                  55                  60                          
tgg ggg ccg gcc gag ccc cgc aag ggc gcg gac atc ctc gtg gag gcg      240
Trp Gly Pro Ala Glu Pro Arg Lys Gly Ala Asp Ile Leu Val Glu Ala         
65                  70                  75                  80          
ctg gag cgg tgc ggc gtc agc gac gtg ttc gcc tac ccg ggc ggc gcg      288
Leu Glu Arg Cys Gly Val Ser Asp Val Phe Ala Tyr Pro Gly Gly Ala         
                85                  90                  95              
tcc atg gag atc cac cag gcg ctg acg cgc tcc ccg gtc atc acc aac      336
Ser Met Glu Ile His Gln Ala Leu Thr Arg Ser Pro Val Ile Thr Asn         
            100                 105                 110               
cac ctc ttc cgc cac gag cag ggc gag gcg ttc gcg gcg tcc ggg tac      384
His Leu Phe Arg His Glu Gln Gly Glu Ala Phe Ala Ala Ser Gly Tyr         
        115                 120                 125                     
gcg cgc gcg tcc ggc cgc gtc ggg gtc tgc gtc gcc acc tcc ggc ccc      432
Ala Arg Ala Ser Gly Arg Val Gly Val Cys Val Ala Thr Ser Gly Pro         
    130                 135                 140                         
ggg gca acc aac ctc gtg tcc gcg ctc gcc gac gcg ctg ctc gac tcc      480
Gly Ala Thr Asn Leu Val Ser Ala Leu Ala Asp Ala Leu Leu Asp Ser         
145                 150                 155                 160         
gtc ccg atg gtc gcc atc acg ggc cag gtc ccc cgc cgc atg atc ggc      528
Val Pro Met Val Ala Ile Thr Gly Gln Val Pro Arg Arg Met Ile Gly         
                165                 170                 175             
acc gac gcc ttc cag gag acg ccc ata gtc gag gtc acc cgc tcc atc      576
Thr Asp Ala Phe Gln Glu Thr Pro Ile Val Glu Val Thr Arg Ser Ile         
            180                 185                 190                 
acc aag cac aat tac ctt gtc ctt gat gtg gag gac atc ccc cgc gtc      624
Thr Lys His Asn Tyr Leu Val Leu Asp Val Glu Asp Ile Pro Arg Val         
        195                 200                 205                     
ata cag gaa gcc ttc ttc ctc gcg tcc tcg ggc cgt cct ggc ccg gtg      672
Ile Gln Glu Ala Phe Phe Leu Ala Ser Ser Gly Arg Pro Gly Pro Val         
    210                 215                 220                         
ctg gtc gac atc ccc aag gac atc cag cag cag atg gtt gtg cca gtc      720
Leu Val Asp Ile Pro Lys Asp Ile Gln Gln Gln Met Val Val Pro Val         
225                 230                 235                 240         
tgg gac acc tcg atg aat cta ccg ggg tac att gca cgc ctg ccc aag      768
Trp Asp Thr Ser Met Asn Leu Pro Gly Tyr Ile Ala Arg Leu Pro Lys         
                245                 250                 255             
cca ccc gcg aca gaa ttg ctt gag cag gtc ttg cgt ctg gtt ggc gag      816
Pro Pro Ala Thr Glu Leu Leu Glu Gln Val Leu Arg Leu Val Gly Glu         
            260                 265                 270                 
tca cgg cgc ccg att ctc tat gtc ggt ggt ggc tgc tct gca tct ggt      864
Ser Arg Arg Pro Ile Leu Tyr Val Gly Gly Gly Cys Ser Ala Ser Gly         
        275                 280                 285                     
gat gaa ttg cgc cgg ttt gtt gag ctg acc ggc atc cca gtt aca acc      912
Asp Glu Leu Arg Arg Phe Val Glu Leu Thr Gly Ile Pro Val Thr Thr         
    290                 295                 300                         
act ctg atg ggc ctc ggc aat ttc ccc agt gat gat ccg ttg tcc ctg      960
Thr Leu Met Gly Leu Gly Asn Phe Pro Ser Asp Asp Pro Leu Ser Leu         
305                 310                 315                 320         
cgc atg ctt ggg atg cat ggc acg gtg tac gca aat tat gcg gtg gat     1008
Arg Met Leu Gly Met His Gly Thr Val Tyr Ala Asn Tyr Ala Val Asp         
                325                 330                 335             
aag gct gac ctg ttg ctt gca ttt ggc gtg cgg ttt gat gat cgt gtg     1056
Lys Ala Asp Leu Leu Leu Ala Phe Gly Val Arg Phe Asp Asp Arg Val         
            340                 345                 350                 
aca ggg aaa att gag gct ttt gca agc agg gcc aag att gtg cac att     1104
Thr Gly Lys Ile Glu Ala Phe Ala Ser Arg Ala Lys Ile Val His Ile         
        355                 360                 365                     
gac att gat cca gcg gag att gga aag aac aag caa cca cat gtg tca     1152
Asp Ile Asp Pro Ala Glu Ile Gly Lys Asn Lys Gln Pro His Val Ser         
    370                 375                 380                         
att tgc gca gat gtt aag ctt gct tta cag ggc ttg aat gct ctg cta     1200
Ile Cys Ala Asp Val Lys Leu Ala Leu Gln Gly Leu Asn Ala Leu Leu         
385                 390                 395                 400         
gac cag agc aca aca aag aca agt tct gat ttt agt gcg tgg cac aat     1248
Asp Gln Ser Thr Thr Lys Thr Ser Ser Asp Phe Ser Ala Trp His Asn         
                405                 410                 415             
gag ttg gac cag cag aag agg gag ttt cct ctg ggg tac aag act ttt     1296
Glu Leu Asp Gln Gln Lys Arg Glu Phe Pro Leu Gly Tyr Lys Thr Phe         
            420                 425                 430                 
ggt gaa gag atc cca ccg caa tat gct att cag gtg ctg gat gag ctg     1344
Gly Glu Glu Ile Pro Pro Gln Tyr Ala Ile Gln Val Leu Asp Glu Leu         
        435                 440                 445                     
acg aaa ggg gag gca atc atc gct act ggt gtt gga cag cac cag atg     1392
Thr Lys Gly Glu Ala Ile Ile Ala Thr Gly Val Gly Gln His Gln Met         
    450                 455                 460                         
tgg gcg gca caa tat tac acc tac aag cgg cca cgg cag tgg ctg tct     1440
Trp Ala Ala Gln Tyr Tyr Thr Tyr Lys Arg Pro Arg Gln Trp Leu Ser         
465                 470                 475                 480         
tcg gct ggt ctg ggc gca atg gga ttt ggg ctg cct gct gca gct ggt     1488
Ser Ala Gly Leu Gly Ala Met Gly Phe Gly Leu Pro Ala Ala Ala Gly         
                485                 490                 495             
gct tct gtg gct aac cca ggt gtc aca gtt gtt gat att gat ggg gat     1536
Ala Ser Val Ala Asn Pro Gly Val Thr Val Val Asp Ile Asp Gly Asp         
            500                 505                 510                 
ggt agc ttc ctc atg aac att cag gag ttg gca ttg atc cgc att gag     1584
Gly Ser Phe Leu Met Asn Ile Gln Glu Leu Ala Leu Ile Arg Ile Glu         
        515                 520                 525                     
aac ctc ccg gtg aag gtg atg gtg ttg aac aac caa cat ttg ggt atg     1632
Asn Leu Pro Val Lys Val Met Val Leu Asn Asn Gln His Leu Gly Met         
    530                 535                 540                        
gtt gtg caa tgg gag gat agg ttt tac aag gca aat agg gcg cat aca     1680
Val Val Gln Trp Glu Asp Arg Phe Tyr Lys Ala Asn Arg Ala His Thr         
545                 550                 555                 560         
tac ttg ggc aac cca gaa tgt gag agt gag ata tat cca gat ttt gtg     1728
Tyr Leu Gly Asn Pro Glu Cys Glu Ser Glu Ile Tyr Pro Asp Phe Val         
                565                 570                 575             
act att gct aaa ggg ttc aat att cct gca gtc cgt gta aca aag aag     1776
Thr Ile Ala Lys Gly Phe Asn Ile Pro Ala Val Arg Val Thr Lys Lys         
            580                 585                 590                 
agt gaa gtc cgt gcc gcc atc aag aag atg ctc gat acc cca ggg cca     1824
Ser Glu Val Arg Ala Ala Ile Lys Lys Met Leu Asp Thr Pro Gly Pro         
        595                 600                 605                     
tac ttg ttg gat atc atc gtc cca cac cag gag cat gtg ctg cct atg     1872
Tyr Leu Leu Asp Ile Ile Val Pro His Gln Glu His Val Leu Pro Met         
    610                 615                 620                         
atc cca agt ggg ggc gca ttc aag gac atg atc ctg gat ggt gat ggc     1920
Ile Pro Ser Gly Gly Ala Phe Lys Asp Met Ile Leu Asp Gly Asp Gly         
625                 630                 635                 640         
agg act gtg tat taa                                                 1935
Arg Thr Val Tyr                                                         

<210>  4
<211>  644
<212>  PRT
<213>  ALSͻͻ
<400>  4
Met Ala Thr Thr Ala Ala Ala Ala Ala Ala Thr Leu Ser Ala Ala Ala 
1               5                   10                  15      
Thr Ala Lys Thr Gly Arg Lys Asn His Gln Arg His His Val Phe Pro 
            20                  25                  30          
Ala Arg Gly Arg Val Gly Ala Ala Ala Val Arg Cys Ser Ala Val Ser 
        35                  40                  45              
Pro Val Thr Pro Pro Ser Pro Ala Pro Pro Ala Thr Pro Leu Arg Pro 
    50                  55                  60                  
Trp Gly Pro Ala Glu Pro Arg Lys Gly Ala Asp Ile Leu Val Glu Ala 
65                  70                  75                  80  
Leu Glu Arg Cys Gly Val Ser Asp Val Phe Ala Tyr Pro Gly Gly Ala 
                85                  90                  95      
Ser Met Glu Ile His Gln Ala Leu Thr Arg Ser Pro Val Ile Thr Asn 
            100                 105                 110         
His Leu Phe Arg His Glu Gln Gly Glu Ala Phe Ala Ala Ser Gly Tyr 
        115                 120                 125             
Ala Arg Ala Ser Gly Arg Val Gly Val Cys Val Ala Thr Ser Gly Pro 
    130                 135                 140                 
Gly Ala Thr Asn Leu Val Ser Ala Leu Ala Asp Ala Leu Leu Asp Ser 
145                 150                 155                 160 
Val Pro Met Val Ala Ile Thr Gly Gln Val Pro Arg Arg Met Ile Gly 
                165                 170                 175     
Thr Asp Ala Phe Gln Glu Thr Pro Ile Val Glu Val Thr Arg Ser Ile 
            180                 185                 190         
Thr Lys His Asn Tyr Leu Val Leu Asp Val Glu Asp Ile Pro Arg Val 
        195                 200                 205             
Ile Gln Glu Ala Phe Phe Leu Ala Ser Ser Gly Arg Pro Gly Pro Val 
    210                 215                 220                 
Leu Val Asp Ile Pro Lys Asp Ile Gln Gln Gln Met Val Val Pro Val 
225                 230                 235                 240 
Trp Asp Thr Ser Met Asn Leu Pro Gly Tyr Ile Ala Arg Leu Pro Lys 
                245                 250                 255     
Pro Pro Ala Thr Glu Leu Leu Glu Gln Val Leu Arg Leu Val Gly Glu 
            260                 265                 270         
Ser Arg Arg Pro Ile Leu Tyr Val Gly Gly Gly Cys Ser Ala Ser Gly 
        275                 280                 285             
Asp Glu Leu Arg Arg Phe Val Glu Leu Thr Gly Ile Pro Val Thr Thr 
    290                 295                 300                 
Thr Leu Met Gly Leu Gly Asn Phe Pro Ser Asp Asp Pro Leu Ser Leu 
305                 310                 315                 320 
Arg Met Leu Gly Met His Gly Thr Val Tyr Ala Asn Tyr Ala Val Asp 
                325                 330                 335     
Lys Ala Asp Leu Leu Leu Ala Phe Gly Val Arg Phe Asp Asp Arg Val 
            340                 345                 350         
Thr Gly Lys Ile Glu Ala Phe Ala Ser Arg Ala Lys Ile Val His Ile 
        355                 360                 365             
Asp Ile Asp Pro Ala Glu Ile Gly Lys Asn Lys Gln Pro His Val Ser 
    370                 375                 380                 
Ile Cys Ala Asp Val Lys Leu Ala Leu Gln Gly Leu Asn Ala Leu Leu 
385                 390                 395                 400 
Asp Gln Ser Thr Thr Lys Thr Ser Ser Asp Phe Ser Ala Trp His Asn 
                405                 410                 415     
Glu Leu Asp Gln Gln Lys Arg Glu Phe Pro Leu Gly Tyr Lys Thr Phe 
            420                 425                 430         
Gly Glu Glu Ile Pro Pro Gln Tyr Ala Ile Gln Val Leu Asp Glu Leu 
        435                 440                 445             
Thr Lys Gly Glu Ala Ile Ile Ala Thr Gly Val Gly Gln His Gln Met 
    450                 455                 460                 
Trp Ala Ala Gln Tyr Tyr Thr Tyr Lys Arg Pro Arg Gln Trp Leu Ser 
465                 470                 475                 480 
Ser Ala Gly Leu Gly Ala Met Gly Phe Gly Leu Pro Ala Ala Ala Gly 
                485                 490                 495     
Ala Ser Val Ala Asn Pro Gly Val Thr Val Val Asp Ile Asp Gly Asp 
            500                 505                 510         
Gly Ser Phe Leu Met Asn Ile Gln Glu Leu Ala Leu Ile Arg Ile Glu 
        515                 520                 525             
Asn Leu Pro Val Lys Val Met Val Leu Asn Asn Gln His Leu Gly Met 
    530                 535                 540                 
Val Val Gln Trp Glu Asp Arg Phe Tyr Lys Ala Asn Arg Ala His Thr 
545                 550                 555                 560 
Tyr Leu Gly Asn Pro Glu Cys Glu Ser Glu Ile Tyr Pro Asp Phe Val 
                565                 570                 575     
Thr Ile Ala Lys Gly Phe Asn Ile Pro Ala Val Arg Val Thr Lys Lys 
            580                 585                 590         
Ser Glu Val Arg Ala Ala Ile Lys Lys Met Leu Asp Thr Pro Gly Pro 
        595                 600                 605             
Tyr Leu Leu Asp Ile Ile Val Pro His Gln Glu His Val Leu Pro Met 
    610                 615                 620                 
Ile Pro Ser Gly Gly Ala Phe Lys Asp Met Ile Leu Asp Gly Asp Gly 
625                 630                 635                 640 
Arg Thr Val Tyr 

<210>  5
<211>  1935
<212>  DNA
<213>  ALS
<220>
<221>  CDS
<222>  (1)..(1935)
<400>  5
atg gct acg acc gcc gcg gcc gcg gcc gcc acc ttg tcc gcc gcc gcg       48
Met Ala Thr Thr Ala Ala Ala Ala Ala Ala Thr Leu Ser Ala Ala Ala         
1               5                   10                  15              
acg gcc aag acc ggc cgt aag aac cag cag cga cac cac gtc ttt ccc       96
Thr Ala Lys Thr Gly Arg Lys Asn Gln Gln Arg His His Val Phe Pro         
            20                  25                  30                  
gct cga ggc cgg gtg ggg gcg gcg gcg gtc agg tgc tcg gcg gtg tcc      144
Ala Arg Gly Arg Val Gly Ala Ala Ala Val Arg Cys Ser Ala Val Ser         
        35                  40                  45                      
ccg gtc acc ccg ccg tcc ccg gcg ccg ccg gcc acg ccg ctc cgg ccg      192
Pro Val Thr Pro Pro Ser Pro Ala Pro Pro Ala Thr Pro Leu Arg Pro         
    50                  55                  60                          
tgg ggg ccg gcc gag ccc cgc aag ggc gcg gac atc ctc gtg gag gcg      240
Trp Gly Pro Ala Glu Pro Arg Lys Gly Ala Asp Ile Leu Val Glu Ala         
65                  70                  75                  80         
ctg gag cgg tgc ggc gtc agc gac gtg ttc gcc tac ccg ggc ggc gcg      288
Leu Glu Arg Cys Gly Val Ser Asp Val Phe Ala Tyr Pro Gly Gly Ala         
                85                  90                  95              
tcc atg gag atc cac cag gcg ctg acg cgc tcc ccg gtc atc acc aac      336
Ser Met Glu Ile His Gln Ala Leu Thr Arg Ser Pro Val Ile Thr Asn         
            100                 105                 110                 
caa ctc ttc cgc cac gag cag ggc gag gcg ttc gcg gcg tcc ggg tac      384
Gln Leu Phe Arg His Glu Gln Gly Glu Ala Phe Ala Ala Ser Gly Tyr         
        115                 120                 125                     
gcg cgc gcg tcc ggc cgc gtc ggg gtc tgc gtc gcc acc tcc ggc ccc      432
Ala Arg Ala Ser Gly Arg Val Gly Val Cys Val Ala Thr Ser Gly Pro         
    130                 135                 140                         
ggg gca acc aac ctc gtg tcc gcg ctc gcc gac gcg ctg ctc gac tcc      480
Gly Ala Thr Asn Leu Val Ser Ala Leu Ala Asp Ala Leu Leu Asp Ser         
145                 150                 155                 160         
gtc ccg atg gtc gcc atc acg ggc cag gtc ccc cgc cgc atg atc ggc      528
Val Pro Met Val Ala Ile Thr Gly Gln Val Pro Arg Arg Met Ile Gly         
                165                 170                 175             
acc gac gcc ttc cag gag acg ccc ata gtc gag gtc acc cgc tcc atc      576
Thr Asp Ala Phe Gln Glu Thr Pro Ile Val Glu Val Thr Arg Ser Ile         
            180                 185                 190                 
acc aag cac aat tac ctt gtc ctt gat gtg gag gac atc ccc cgc gtc      624
Thr Lys His Asn Tyr Leu Val Leu Asp Val Glu Asp Ile Pro Arg Val         
        195                 200                 205                    
ata cag gaa gcc ttc ttc ctc gcg tcc tcg ggc cgt cct ggc ccg gtg      672
Ile Gln Glu Ala Phe Phe Leu Ala Ser Ser Gly Arg Pro Gly Pro Val         
    210                 215                 220                         
ctg gtc gac atc ccc aag gac atc cag cag cag atg gct gtg cca gtc      720
Leu Val Asp Ile Pro Lys Asp Ile Gln Gln Gln Met Ala Val Pro Val         
225                 230                 235                 240         
tgg gac acc tcg atg aat cta ccg ggg tac att gca cgc ctg ccc aag      768
Trp Asp Thr Ser Met Asn Leu Pro Gly Tyr Ile Ala Arg Leu Pro Lys         
                245                 250                 255             
cca ccc gcg aca gaa ttg ctt gag cag gtc ttg cgt ctg gtt ggc gag      816
Pro Pro Ala Thr Glu Leu Leu Glu Gln Val Leu Arg Leu Val Gly Glu         
            260                 265                 270                 
tca cgg cgc ccg att ctc tat gtc ggt ggt ggc tgc tct gca tct ggt      864
Ser Arg Arg Pro Ile Leu Tyr Val Gly Gly Gly Cys Ser Ala Ser Gly         
        275                 280                 285                     
gat gaa ttg cgc cgg ttt gtt gag ctg acc ggc atc cca gtt aca acc      912
Asp Glu Leu Arg Arg Phe Val Glu Leu Thr Gly Ile Pro Val Thr Thr         
    290                 295                 300                         
act ctg atg ggc ctc ggc aat ttc ccc agt gat gat ccg ttg tcc ctg      960
Thr Leu Met Gly Leu Gly Asn Phe Pro Ser Asp Asp Pro Leu Ser Leu         
305                 310                 315                 320         
cgc atg ctt ggg atg cat ggc acg gtg tac gca aat tat gcg gtg gat     1008
Arg Met Leu Gly Met His Gly Thr Val Tyr Ala Asn Tyr Ala Val Asp         
                325                 330                 335             
aag gct gac ctg ttg ctt gca ttt ggc gtg cgg ttt gat gat cgt gtg     1056
Lys Ala Asp Leu Leu Leu Ala Phe Gly Val Arg Phe Asp Asp Arg Val         
            340                 345                 350               
aca ggg aaa att gag gct ttt gca agc agg gcc aag att gtg cac att     1104
Thr Gly Lys Ile Glu Ala Phe Ala Ser Arg Ala Lys Ile Val His Ile         
        355                 360                 365                     
gac att gat cca gcg gag att gga aag aac aag caa cca cat gtg tca     1152
Asp Ile Asp Pro Ala Glu Ile Gly Lys Asn Lys Gln Pro His Val Ser         
    370                 375                 380                         
att tgc gca gat gtt aag ctt gct tta cag ggc ttg aat gct ctg cta     1200
Ile Cys Ala Asp Val Lys Leu Ala Leu Gln Gly Leu Asn Ala Leu Leu         
385                 390                 395                 400         
gac cag agc aca aca aag aca agt tct gat ttt agt gcg tgg cac aat     1248
Asp Gln Ser Thr Thr Lys Thr Ser Ser Asp Phe Ser Ala Trp His Asn         
                405                 410                 415             
gag ttg gac cag cag aag agg gag ttt cct ctg ggg tac aag act ttt     1296
Glu Leu Asp Gln Gln Lys Arg Glu Phe Pro Leu Gly Tyr Lys Thr Phe         
            420                 425                 430                 
ggt gaa gag atc cca ccg caa tat gct att cag gtg ctg gat gag ctg     1344
Gly Glu Glu Ile Pro Pro Gln Tyr Ala Ile Gln Val Leu Asp Glu Leu         
        435                 440                 445                     
acg aaa ggg gag gca atc atc gct act ggt gtt gga cag cac cag atg     1392
Thr Lys Gly Glu Ala Ile Ile Ala Thr Gly Val Gly Gln His Gln Met         
    450                 455                 460                         
tgg gcg gca caa tat tac acc tac aag cgg cca cgg cag tgg ctg tct     1440
Trp Ala Ala Gln Tyr Tyr Thr Tyr Lys Arg Pro Arg Gln Trp Leu Ser         
465                 470                 475                 480         
tcg gct ggt ctg ggc gca atg gga ttt ggg ctg cct gct gca gct ggt     1488
Ser Ala Gly Leu Gly Ala Met Gly Phe Gly Leu Pro Ala Ala Ala Gly         
                485                 490                 495             
gct tct gtg gct aac cca ggt gtc aca gtt gtt gat att gat ggg gat     1536
Ala Ser Val Ala Asn Pro Gly Val Thr Val Val Asp Ile Asp Gly Asp         
            500                 505                 510                 
ggt agc ttc ctc atg aac att cag gag ttg gca ttg atc cgc att gag     1584
Gly Ser Phe Leu Met Asn Ile Gln Glu Leu Ala Leu Ile Arg Ile Glu         
        515                 520                 525                     
aac ctc ccg gtg aag gtg atg gtg ttg aac aac caa cat ttg ggt atg     1632
Asn Leu Pro Val Lys Val Met Val Leu Asn Asn Gln His Leu Gly Met         
    530                 535                 540                         
gtt gtg caa tgg gag gat agg ttt tac aag gca aat agg gcg cat aca     1680
Val Val Gln Trp Glu Asp Arg Phe Tyr Lys Ala Asn Arg Ala His Thr         
545                 550                 555                 560         
tac ttg ggc aac cca gaa tgt gag agt gag ata tat cca gat ttt gtg     1728
Tyr Leu Gly Asn Pro Glu Cys Glu Ser Glu Ile Tyr Pro Asp Phe Val         
                565                 570                 575             
act att gct aaa ggg ttc aat att cct gca gtc cgt gta aca aag aag     1776
Thr Ile Ala Lys Gly Phe Asn Ile Pro Ala Val Arg Val Thr Lys Lys         
            580                 585                 590                 
agt gaa gtc cgt gcc gcc atc aag aag atg ctc gat acc cca ggg cca     1824
Ser Glu Val Arg Ala Ala Ile Lys Lys Met Leu Asp Thr Pro Gly Pro         
        595                 600                 605                     
tac ttg ttg gat atc atc gtc cca cac cag gag cat gtg ctg cct atg     1872
Tyr Leu Leu Asp Ile Ile Val Pro His Gln Glu His Val Leu Pro Met         
    610                 615                 620                         
atc cca agt ggg ggc gca ttc aag gac atg atc ctg gat ggt gat ggc     1920
Ile Pro Ser Gly Gly Ala Phe Lys Asp Met Ile Leu Asp Gly Asp Gly         
625                 630                 635                 640         
agg act gtg tat taa                                                 1935
Arg Thr Val Tyr                                                         

<210>  6
<211>  644
<212>  PRT
<213>  ALS
<400>  6
Met Ala Thr Thr Ala Ala Ala Ala Ala Ala Thr Leu Ser Ala Ala Ala 
1               5                   10                  15      
Thr Ala Lys Thr Gly Arg Lys Asn Gln Gln Arg His His Val Phe Pro 
            20                  25                  30          
Ala Arg Gly Arg Val Gly Ala Ala Ala Val Arg Cys Ser Ala Val Ser 
        35                  40                  45              
Pro Val Thr Pro Pro Ser Pro Ala Pro Pro Ala Thr Pro Leu Arg Pro 
    50                  55                  60                  
Trp Gly Pro Ala Glu Pro Arg Lys Gly Ala Asp Ile Leu Val Glu Ala 
65                  70                  75                  80  
Leu Glu Arg Cys Gly Val Ser Asp Val Phe Ala Tyr Pro Gly Gly Ala 
                85                  90                  95      
Ser Met Glu Ile His Gln Ala Leu Thr Arg Ser Pro Val Ile Thr Asn 
            100                 105                 110         
Gln Leu Phe Arg His Glu Gln Gly Glu Ala Phe Ala Ala Ser Gly Tyr 
        115                 120                 125             
Ala Arg Ala Ser Gly Arg Val Gly Val Cys Val Ala Thr Ser Gly Pro 
    130                 135                 140                 
Gly Ala Thr Asn Leu Val Ser Ala Leu Ala Asp Ala Leu Leu Asp Ser 
145                 150                 155                 160 
Val Pro Met Val Ala Ile Thr Gly Gln Val Pro Arg Arg Met Ile Gly 
                165                 170                 175     
Thr Asp Ala Phe Gln Glu Thr Pro Ile Val Glu Val Thr Arg Ser Ile 
            180                 185                 190         
Thr Lys His Asn Tyr Leu Val Leu Asp Val Glu Asp Ile Pro Arg Val 
        195                 200                 205             
Ile Gln Glu Ala Phe Phe Leu Ala Ser Ser Gly Arg Pro Gly Pro Val 
    210                 215                 220                 
Leu Val Asp Ile Pro Lys Asp Ile Gln Gln Gln Met Ala Val Pro Val 
225                 230                 235                 240 
Trp Asp Thr Ser Met Asn Leu Pro Gly Tyr Ile Ala Arg Leu Pro Lys 
                245                 250                 255     
Pro Pro Ala Thr Glu Leu Leu Glu Gln Val Leu Arg Leu Val Gly Glu 
            260                 265                 270         
Ser Arg Arg Pro Ile Leu Tyr Val Gly Gly Gly Cys Ser Ala Ser Gly 
        275                 280                 285             
Asp Glu Leu Arg Arg Phe Val Glu Leu Thr Gly Ile Pro Val Thr Thr 
    290                 295                 300                 
Thr Leu Met Gly Leu Gly Asn Phe Pro Ser Asp Asp Pro Leu Ser Leu 
305                 310                 315                 320 
Arg Met Leu Gly Met His Gly Thr Val Tyr Ala Asn Tyr Ala Val Asp 
                325                 330                 335     
Lys Ala Asp Leu Leu Leu Ala Phe Gly Val Arg Phe Asp Asp Arg Val 
            340                 345                 350         
Thr Gly Lys Ile Glu Ala Phe Ala Ser Arg Ala Lys Ile Val His Ile 
        355                 360                 365             
Asp Ile Asp Pro Ala Glu Ile Gly Lys Asn Lys Gln Pro His Val Ser 
    370                 375                 380                 
Ile Cys Ala Asp Val Lys Leu Ala Leu Gln Gly Leu Asn Ala Leu Leu 
385                 390                 395                 400 
Asp Gln Ser Thr Thr Lys Thr Ser Ser Asp Phe Ser Ala Trp His Asn 
                405                 410                 415     
Glu Leu Asp Gln Gln Lys Arg Glu Phe Pro Leu Gly Tyr Lys Thr Phe 
            420                 425                 430         
Gly Glu Glu Ile Pro Pro Gln Tyr Ala Ile Gln Val Leu Asp Glu Leu 
        435                 440                 445             
Thr Lys Gly Glu Ala Ile Ile Ala Thr Gly Val Gly Gln His Gln Met 
    450                 455                 460                 
Trp Ala Ala Gln Tyr Tyr Thr Tyr Lys Arg Pro Arg Gln Trp Leu Ser 
465                 470                 475                 480 
Ser Ala Gly Leu Gly Ala Met Gly Phe Gly Leu Pro Ala Ala Ala Gly 
                485                 490                 495     
Ala Ser Val Ala Asn Pro Gly Val Thr Val Val Asp Ile Asp Gly Asp 
            500                 505                 510         
Gly Ser Phe Leu Met Asn Ile Gln Glu Leu Ala Leu Ile Arg Ile Glu 
        515                 520                 525             
Asn Leu Pro Val Lys Val Met Val Leu Asn Asn Gln His Leu Gly Met 
    530                 535                 540                 
Val Val Gln Trp Glu Asp Arg Phe Tyr Lys Ala Asn Arg Ala His Thr 
545                 550                 555                 560 
Tyr Leu Gly Asn Pro Glu Cys Glu Ser Glu Ile Tyr Pro Asp Phe Val 
                565                 570                 575     
Thr Ile Ala Lys Gly Phe Asn Ile Pro Ala Val Arg Val Thr Lys Lys 
            580                 585                 590         
Ser Glu Val Arg Ala Ala Ile Lys Lys Met Leu Asp Thr Pro Gly Pro 
        595                 600                 605             
Tyr Leu Leu Asp Ile Ile Val Pro His Gln Glu His Val Leu Pro Met 
    610                 615                 620                 
Ile Pro Ser Gly Gly Ala Phe Lys Asp Met Ile Leu Asp Gly Asp Gly 
625                 630                 635                 640 
Arg Thr Val Tyr 


<210>  7
<211>  30
<212>  DNA
<213>  
<400>  7
cgcggatcca tccgagccac acatcgcctc                                      30


<210>  8
<211>  28
<212>  DNA
<213>  

<400>  8
tccccgcggc ctacggaaaa caacacac                                        28
