                         SEQUENCE LISTING

<110>  Janssen Biotech, Inc.
	 Chen, Guang
       Sun, Yu
       Wang, Dai
       Wittenberg, Gayle
 
<120>  Treatment of Depression Using Agents that Block Binding of IL-6 
       to IL-6 Receptor

<130>  JBI5083WOPCT

<140>  To Be Assigned
<141>  2017-04-06

<150>  62/319558
<151>  2016-04-07

<160>  146   

<170>  PatentIn version 3.5

<210>  1
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  1

Ser Ala Ser His Ser Val Ser Tyr Met Tyr 
1               5                   10  


<210>  2
<211>  30
<212>  PRT
<213>  Homo sapiens

<400>  2

Ala Gly Thr Gly Cys Cys Ala Gly Cys Cys Ala Thr Ala Gly Thr Gly 
1               5                   10                  15      


Thr Ala Ala Gly Thr Thr Ala Cys Ala Thr Gly Thr Ala Cys 
            20                  25                  30  


<210>  3
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  3

Ser Ala Ser Ile Ser Val Ser Tyr Met Tyr 
1               5                   10  


<210>  4
<211>  30
<212>  PRT
<213>  Homo sapiens

<400>  4

Ala Gly Thr Gly Cys Cys Ala Gly Cys Ala Thr Thr Ala Gly Thr Gly 
1               5                   10                  15      


Thr Ala Ala Gly Thr Thr Ala Cys Ala Thr Gly Thr Ala Cys 
            20                  25                  30  


<210>  5
<211>  10
<212>  PRT
<213>  Homo sapeins

<400>  5

Ser Ala Arg Ser Ser Val Ser Tyr Met Tyr 
1               5                   10  


<210>  6
<211>  30
<212>  PRT
<213>  Homo sapiens

<400>  6

Ala Gly Thr Gly Cys Cys Cys Gly Gly Thr Cys Ala Ala Gly Thr Gly 
1               5                   10                  15      


Thr Ala Ala Gly Thr Thr Ala Cys Ala Thr Gly Thr Ala Cys 
            20                  25                  30  


<210>  7
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  7

Ser Ala Ser Tyr Ser Val Ser Tyr Met Tyr 
1               5                   10  


<210>  8
<211>  30
<212>  PRT
<213>  Homo sapiens

<400>  8

Ala Gly Thr Gly Cys Cys Ala Gly Cys Thr Ala Thr Ala Gly Thr Gly 
1               5                   10                  15      


Thr Ala Ala Gly Thr Thr Ala Cys Ala Thr Gly Thr Ala Cys 
            20                  25                  30  


<210>  9
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  9

Ser Ala Ser Ser Ser Val Phe Tyr Met Tyr 
1               5                   10  


<210>  10
<211>  30
<212>  PRT
<213>  Homo sapiens

<400>  10

Ala Gly Thr Gly Cys Cys Ala Gly Cys Thr Cys Ala Ala Gly Thr Gly 
1               5                   10                  15      


Thr Ala Thr Thr Thr Thr Ala Cys Ala Thr Gly Thr Ala Cys 
            20                  25                  30  


<210>  11
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  11

Ser Gly Ser Ser Tyr Val Ser Tyr Met Tyr 
1               5                   10  


<210>  12
<211>  30
<212>  PRT
<213>  Homo sapiens

<400>  12

Ala Gly Thr Gly Gly Cys Ala Gly Cys Thr Cys Ala Thr Ala Thr Gly 
1               5                   10                  15      


Thr Ala Ala Gly Thr Thr Ala Cys Ala Thr Gly Thr Ala Cys 
            20                  25                  30  


<210>  13
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  13

Ser Ala Leu Ser Ser Val Ser Tyr Met Tyr 
1               5                   10  


<210>  14
<211>  30
<212>  PRT
<213>  Homo sapiens

<400>  14

Ala Gly Thr Gly Cys Cys Cys Thr Gly Thr Cys Ala Ala Gly Thr Gly 
1               5                   10                  15      


Thr Ala Ala Gly Thr Thr Ala Cys Ala Thr Gly Thr Ala Cys 
            20                  25                  30  


<210>  15
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  15

Ser Ala Ser Ser Ser Val Ser Tyr Met Tyr 
1               5                   10  


<210>  16
<211>  30
<212>  PRT
<213>  Homo sapiens

<400>  16

Ala Gly Thr Gly Cys Cys Ala Gly Cys Thr Cys Ala Ala Gly Thr Gly 
1               5                   10                  15      


Thr Ala Ala Gly Thr Thr Ala Cys Ala Thr Gly Thr Ala Cys 
            20                  25                  30  


<210>  17
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  17

Asp Phe Ser Asn Leu Ala Ser 
1               5           


<210>  18
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  18

Gly Ala Cys Thr Thr Thr Thr Cys Cys Ala Ala Cys Cys Thr Gly Gly 
1               5                   10                  15      


Cys Thr Thr Cys Thr 
            20      


<210>  19
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  19

Asp Leu Ser Asn Leu Ala Ser 
1               5           


<210>  20
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  20

Gly Ala Cys Cys Thr Gly Thr Cys Cys Ala Ala Cys Cys Thr Gly Gly 
1               5                   10                  15      


Cys Thr Thr Cys Thr 
            20      


<210>  21
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  21

Asp Met Ser Asn Leu Ala Ser 
1               5           


<210>  22
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  22

Gly Ala Cys Ala Thr Gly Thr Cys Cys Ala Ala Cys Cys Thr Gly Gly 
1               5                   10                  15      


Cys Thr Thr Cys Thr 
            20      


<210>  23
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  23

Asp Thr Ser Asn Leu Thr Ser 
1               5           


<210>  24
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  24

Gly Ala Cys Ala Cys Ala Thr Cys Cys Ala Ala Cys Cys Thr Gly Ala 
1               5                   10                  15      


Cys Gly Thr Cys Thr 
            20      


<210>  25
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  25

Asp Thr Ser Glu Leu Ala Ser 
1               5           


<210>  26
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  26

Gly Ala Cys Ala Cys Ala Thr Cys Cys Gly Ala Gly Cys Thr Gly Gly 
1               5                   10                  15      


Cys Thr Thr Cys Thr 
            20      


<210>  27
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  27

Asp Thr Ser Asn Leu Ala Ser 
1               5           


<210>  28
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  28

Gly Ala Cys Ala Cys Ala Thr Cys Cys Ala Ala Cys Cys Thr Gly Gly 
1               5                   10                  15      


Cys Thr Thr Cys Thr 
            20      


<210>  29
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  29

Met Gln Trp Ser Gly Tyr Pro Tyr Thr 
1               5                   


<210>  30
<211>  27
<212>  PRT
<213>  Homo sapiens

<400>  30

Ala Thr Gly Cys Ala Gly Thr Gly Gly Ala Gly Thr Gly Gly Thr Thr 
1               5                   10                  15      


Ala Cys Cys Cys Ala Thr Ala Cys Ala Cys Gly 
            20                  25          


<210>  31
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  31

Cys Gln Trp Ser Gly Tyr Pro Tyr Thr 
1               5                   


<210>  32
<211>  27
<212>  PRT
<213>  Homo sapiens

<400>  32

Thr Gly Thr Cys Ala Gly Thr Gly Gly Ala Gly Thr Gly Gly Thr Thr 
1               5                   10                  15      


Ala Cys Cys Cys Ala Thr Ala Cys Ala Cys Gly 
            20                  25          


<210>  33
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  33

Ser Cys Trp Ser Gly Tyr Pro Tyr Thr 
1               5                   


<210>  34
<211>  27
<212>  PRT
<213>  Homo sapiens

<400>  34

Thr Cys Thr Gly Thr Gly Thr Gly Gly Ala Gly Thr Gly Gly Thr Thr 
1               5                   10                  15      


Ala Cys Cys Cys Ala Thr Ala Cys Ala Cys Gly 
            20                  25          


<210>  35
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  35

Ser Gln Trp Ser Gly Tyr Pro Tyr Thr 
1               5                   


<210>  36
<211>  27
<212>  PRT
<213>  Homo sapiens

<400>  36

Thr Cys Thr Cys Ala Gly Thr Gly Gly Ala Gly Thr Gly Gly Thr Thr 
1               5                   10                  15      


Ala Cys Cys Cys Ala Thr Ala Cys Ala Cys Gly 
            20                  25          


<210>  37
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  37

Gly Phe Thr Phe Ser Ser Phe Ala Leu Ser 
1               5                   10  


<210>  38
<211>  30
<212>  PRT
<213>  Homo sapiens

<400>  38

Gly Gly Ala Thr Thr Cys Ala Cys Cys Thr Thr Thr Ala Gly Thr Ala 
1               5                   10                  15      


Gly Cys Thr Thr Thr Gly Cys Cys Cys Thr Thr Thr Cys Thr 
            20                  25                  30  


<210>  39
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  39

Gly Phe Thr Phe Ser Pro Phe Ala Met Ser 
1               5                   10  


<210>  40
<211>  30
<212>  PRT
<213>  Homo sapiens

<400>  40

Gly Gly Ala Thr Thr Cys Ala Cys Cys Thr Thr Thr Ala Gly Thr Cys 
1               5                   10                  15      


Cys Thr Thr Thr Thr Gly Cys Cys Ala Thr Gly Thr Cys Thr 
            20                  25                  30  


<210>  41
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  41

Gly Phe Gln Phe Ser Ser Phe Ala Met Ser 
1               5                   10  


<210>  42
<211>  30
<212>  PRT
<213>  Homo sapiens

<400>  42

Gly Gly Ala Thr Thr Cys Cys Ala Gly Thr Thr Thr Ala Gly Thr Ala 
1               5                   10                  15      


Gly Cys Thr Thr Thr Gly Cys Cys Ala Thr Gly Thr Cys Thr 
            20                  25                  30  


<210>  43
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  43

Gly Phe Thr Thr Ser Ser Phe Ala Met Ser 
1               5                   10  


<210>  44
<211>  30
<212>  PRT
<213>  Homo sapiens

<400>  44

Gly Gly Ala Thr Thr Cys Ala Cys Cys Ala Cys Thr Ala Gly Thr Ala 
1               5                   10                  15      


Gly Cys Thr Thr Thr Gly Cys Cys Ala Thr Gly Thr Cys Thr 
            20                  25                  30  


<210>  45
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  45

Gly Phe Gln Phe Ser Pro Phe Ala Met Ser 
1               5                   10  


<210>  46
<211>  30
<212>  PRT
<213>  Homo sapiens

<400>  46

Gly Gly Ala Thr Thr Cys Cys Ala Gly Thr Thr Thr Ala Gly Thr Cys 
1               5                   10                  15      


Cys Thr Thr Thr Thr Gly Cys Cys Ala Thr Gly Thr Cys Thr 
            20                  25                  30  


<210>  47
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  47

Gly Phe Thr Phe Ser Ser Phe Ala Met Ser 
1               5                   10  


<210>  48
<211>  30
<212>  PRT
<213>  Homo sapiens

<400>  48

Gly Gly Ala Thr Thr Cys Ala Cys Cys Thr Thr Thr Ala Gly Thr Ala 
1               5                   10                  15      


Gly Cys Thr Thr Thr Gly Cys Cys Ala Thr Gly Thr Cys Thr 
            20                  25                  30  


<210>  49
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  49

Lys Ala Ser Ser Gly Gly Ser Tyr Thr Tyr Tyr Pro Asp Thr Val Thr 
1               5                   10                  15      


Gly 
    


<210>  50
<211>  51
<212>  PRT
<213>  Homo sapiens

<400>  50

Ala Ala Ala Gly Cys Gly Ala Gly Thr Ala Gly Thr Gly Gly Thr Gly 
1               5                   10                  15      


Gly Gly Ala Gly Thr Thr Ala Cys Ala Cys Cys Thr Ala Cys Thr Ala 
            20                  25                  30          


Thr Cys Cys Thr Gly Ala Cys Ala Cys Thr Gly Thr Gly Ala Cys Gly 
        35                  40                  45              


Gly Gly Cys 
    50      


<210>  51
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  51

Lys Ile Ser Ser Gly Gly Ser Tyr Glu Tyr Tyr Pro Asp Thr Val Thr 
1               5                   10                  15      


Gly 
    


<210>  52
<211>  51
<212>  PRT
<213>  Homo sapiens

<400>  52

Ala Ala Ala Ala Thr Thr Ala Gly Thr Ala Gly Thr Gly Gly Thr Gly 
1               5                   10                  15      


Gly Gly Ala Gly Thr Thr Ala Cys Gly Ala Gly Thr Ala Cys Thr Ala 
            20                  25                  30          


Thr Cys Cys Thr Gly Ala Cys Ala Cys Thr Gly Thr Gly Ala Cys Gly 
        35                  40                  45              


Gly Gly Cys 
    50      


<210>  53
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  53

Lys Ile Ser Ser Gly Gly Ser Tyr Tyr Tyr Tyr Pro Asp Thr Val Thr 
1               5                   10                  15      


Gly 
    


<210>  54
<211>  51
<212>  PRT
<213>  Homo sapiens

<400>  54

Ala Ala Ala Ala Thr Thr Ala Gly Thr Ala Gly Thr Gly Gly Thr Gly 
1               5                   10                  15      


Gly Gly Ala Gly Thr Thr Ala Cys Thr Ala Thr Thr Ala Cys Thr Ala 
            20                  25                  30          


Thr Cys Cys Thr Gly Ala Cys Ala Cys Thr Gly Thr Gly Ala Cys Gly 
        35                  40                  45              


Gly Gly Cys 
    50      


<210>  55
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  55

Lys Ile Ser Ser Gly Gly Ser Trp Thr Tyr Tyr Pro Asp Thr Val Thr 
1               5                   10                  15      


Gly 
    


<210>  56
<211>  51
<212>  PRT
<213>  Homo sapiens

<400>  56

Ala Ala Ala Ala Thr Thr Ala Gly Thr Ala Gly Thr Gly Gly Thr Gly 
1               5                   10                  15      


Gly Gly Ala Gly Thr Thr Gly Gly Ala Cys Cys Thr Ala Cys Thr Ala 
            20                  25                  30          


Thr Cys Cys Thr Gly Ala Cys Ala Cys Thr Gly Thr Gly Ala Cys Gly 
        35                  40                  45              


Gly Gly Cys 
    50      


<210>  57
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  57

Lys Ile Ser Pro Gly Gly Ser Tyr Thr Tyr Tyr Pro Asp Thr Val Thr 
1               5                   10                  15      


Gly 
    


<210>  58
<211>  51
<212>  PRT
<213>  Homo sapiens

<400>  58

Ala Ala Ala Ala Thr Thr Ala Gly Thr Cys Cys Gly Gly Gly Thr Gly 
1               5                   10                  15      


Gly Gly Ala Gly Thr Thr Ala Cys Ala Cys Cys Thr Ala Cys Thr Ala 
            20                  25                  30          


Thr Cys Cys Thr Gly Ala Cys Ala Cys Thr Gly Thr Gly Ala Cys Gly 
        35                  40                  45              


Gly Gly Cys 
    50      


<210>  59
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  59

Lys Ile Ser Pro Gly Gly Ser Trp Thr Tyr Tyr Ser Asp Thr Val Thr 
1               5                   10                  15      


Gly 
    


<210>  60
<211>  51
<212>  PRT
<213>  Homo sapiens

<400>  60

Ala Ala Ala Ala Thr Thr Ala Gly Thr Cys Cys Gly Gly Gly Thr Gly 
1               5                   10                  15      


Gly Gly Ala Gly Thr Thr Gly Gly Ala Cys Cys Thr Ala Cys Thr Ala 
            20                  25                  30          


Thr Thr Cys Thr Gly Ala Cys Ala Cys Thr Gly Thr Gly Ala Cys Gly 
        35                  40                  45              


Gly Gly Cys 
    50      


<210>  61
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  61

Lys Ile Ser Ser Gly Gly Ser Tyr Thr Tyr Tyr Pro Asp Thr Val Thr 
1               5                   10                  15      


Gly 
    


<210>  62
<211>  51
<212>  PRT
<213>  Homo sapiens

<400>  62

Ala Ala Ala Ala Thr Thr Ala Gly Thr Ala Gly Thr Gly Gly Thr Gly 
1               5                   10                  15      


Gly Gly Ala Gly Thr Thr Ala Cys Ala Cys Cys Thr Ala Cys Thr Ala 
            20                  25                  30          


Thr Cys Cys Thr Gly Ala Cys Ala Cys Thr Gly Thr Gly Ala Cys Gly 
        35                  40                  45              


Gly Gly Cys 
    50      


<210>  63
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  63

Lys Ile Ser Ser Gly Gly Ser Tyr Thr Tyr Phe Pro Asp Thr Val Thr 
1               5                   10                  15      


Gly 
    


<210>  64
<211>  51
<212>  PRT
<213>  Homo sapiens

<400>  64

Ala Ala Ala Ala Thr Thr Ala Gly Thr Ala Gly Thr Gly Gly Thr Gly 
1               5                   10                  15      


Gly Gly Ala Gly Thr Thr Ala Cys Ala Cys Cys Thr Ala Cys Thr Thr 
            20                  25                  30          


Thr Cys Cys Thr Gly Ala Cys Ala Cys Thr Gly Thr Gly Ala Cys Gly 
        35                  40                  45              


Gly Gly Cys 
    50      


<210>  65
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  65

Lys Ile Ser Ser Gly Gly Ser Tyr Thr Tyr Tyr Pro Asp Thr Val Ala 
1               5                   10                  15      


Gly 
    


<210>  66
<211>  51
<212>  PRT
<213>  Homo sapiens

<400>  66

Ala Ala Ala Ala Thr Thr Ala Gly Thr Ala Gly Thr Gly Gly Thr Gly 
1               5                   10                  15      


Gly Gly Ala Gly Thr Thr Ala Cys Ala Cys Cys Thr Ala Cys Thr Ala 
            20                  25                  30          


Thr Cys Cys Thr Gly Ala Cys Ala Cys Thr Gly Thr Gly Gly Cys Thr 
        35                  40                  45              


Gly Gly Cys 
    50      


<210>  67
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  67

Lys Ile Ser Ser Gly Gly Ser Tyr Thr Tyr Tyr Asp Asp Thr Val Thr 
1               5                   10                  15      


Gly 
    


<210>  68
<211>  51
<212>  PRT
<213>  Homo sapiens

<400>  68

Ala Ala Ala Ala Thr Thr Ala Gly Thr Ala Gly Thr Gly Gly Thr Gly 
1               5                   10                  15      


Gly Gly Ala Gly Thr Thr Ala Cys Ala Cys Cys Thr Ala Cys Thr Ala 
            20                  25                  30          


Thr Gly Ala Thr Gly Ala Cys Ala Cys Thr Gly Thr Gly Ala Cys Gly 
        35                  40                  45              


Gly Gly Cys 
    50      


<210>  69
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  69

Lys Ile Ser Ser Gly Gly Ser Tyr Thr Tyr Tyr Ser Asp Thr Val Thr 
1               5                   10                  15      


Gly 
    


<210>  70
<211>  51
<212>  PRT
<213>  Homo sapiens

<400>  70

Ala Ala Ala Ala Thr Thr Ala Gly Thr Ala Gly Thr Gly Gly Thr Gly 
1               5                   10                  15      


Gly Gly Ala Gly Thr Thr Ala Cys Ala Cys Cys Thr Ala Cys Thr Ala 
            20                  25                  30          


Thr Thr Cys Thr Gly Ala Cys Ala Cys Thr Gly Thr Gly Ala Cys Gly 
        35                  40                  45              


Gly Gly Cys 
    50      


<210>  71
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  71

Lys Ile Ser Ser Gly Gly Ser Tyr Thr Tyr Tyr Pro Asp Thr Val Thr 
1               5                   10                  15      


Pro 
    


<210>  72
<211>  51
<212>  PRT
<213>  Homo sapiens

<400>  72

Ala Ala Ala Ala Thr Thr Ala Gly Thr Ala Gly Thr Gly Gly Thr Gly 
1               5                   10                  15      


Gly Gly Ala Gly Thr Thr Ala Cys Ala Cys Cys Thr Ala Cys Thr Ala 
            20                  25                  30          


Thr Cys Cys Thr Gly Ala Cys Ala Cys Thr Gly Thr Gly Ala Cys Gly 
        35                  40                  45              


Cys Cys Gly 
    50      


<210>  73
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  73

Lys Ile Ser Ser Gly Gly Ser Tyr Thr Tyr Tyr Pro Asp Thr Asp Thr 
1               5                   10                  15      


Gly 
    


<210>  74
<211>  51
<212>  PRT
<213>  Homo sapiens

<400>  74

Ala Ala Ala Ala Thr Thr Ala Gly Thr Ala Gly Thr Gly Gly Thr Gly 
1               5                   10                  15      


Gly Gly Ala Gly Thr Thr Ala Cys Ala Cys Cys Thr Ala Cys Thr Ala 
            20                  25                  30          


Thr Cys Cys Thr Gly Ala Cys Ala Cys Thr Gly Ala Thr Ala Cys Gly 
        35                  40                  45              


Gly Gly Cys 
    50      


<210>  75
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  75

Lys Ile Ser Pro Gly Gly Ser Tyr Thr Tyr Tyr Ser Asp Thr Val Thr 
1               5                   10                  15      


Gly 
    


<210>  76
<211>  51
<212>  PRT
<213>  Homo sapiens

<400>  76

Ala Ala Ala Ala Thr Thr Ala Gly Thr Cys Cys Gly Gly Gly Thr Gly 
1               5                   10                  15      


Gly Gly Ala Gly Thr Thr Ala Cys Ala Cys Cys Thr Ala Cys Thr Ala 
            20                  25                  30          


Thr Thr Cys Thr Gly Ala Cys Ala Cys Thr Gly Thr Gly Ala Cys Gly 
        35                  40                  45              


Gly Gly Cys 
    50      


<210>  77
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  77

Lys Ile Ser Pro Gly Gly Ser Trp Thr Tyr Tyr Asp Asp Thr Val Thr 
1               5                   10                  15      


Gly 
    


<210>  78
<211>  51
<212>  PRT
<213>  Homo sapiens

<400>  78

Ala Ala Ala Ala Thr Thr Ala Gly Thr Cys Cys Gly Gly Gly Thr Gly 
1               5                   10                  15      


Gly Gly Ala Gly Thr Thr Gly Gly Ala Cys Cys Thr Ala Cys Thr Ala 
            20                  25                  30          


Thr Gly Ala Thr Gly Ala Cys Ala Cys Thr Gly Thr Gly Ala Cys Gly 
        35                  40                  45              


Gly Gly Cys 
    50      


<210>  79
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  79

Gln Leu Trp Gly Ser Tyr Ala Leu Asp Tyr 
1               5                   10  


<210>  80
<211>  30
<212>  PRT
<213>  Homo sapiens

<400>  80

Cys Ala Gly Thr Thr Ala Thr Gly Gly Gly Gly Gly Thr Cys Gly Thr 
1               5                   10                  15      


Ala Thr Gly Cys Thr Cys Thr Thr Gly Ala Cys Thr Ala Cys 
            20                  25                  30  


<210>  81
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  81

Gln Leu Trp Gly Tyr Tyr Ala Leu Asp Thr 
1               5                   10  


<210>  82
<211>  30
<212>  PRT
<213>  Homo sapiens

<400>  82

Cys Ala Gly Thr Thr Ala Thr Gly Gly Gly Gly Gly Thr Ala Cys Thr 
1               5                   10                  15      


Ala Thr Gly Cys Thr Cys Thr Thr Gly Ala Cys Ala Cys Gly 
            20                  25                  30  


<210>  83
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  83

Gln Leu Trp Gly Thr Tyr Ala Leu Asp Tyr 
1               5                   10  


<210>  84
<211>  30
<212>  PRT
<213>  Homo sapiens

<400>  84

Cys Ala Gly Thr Thr Ala Thr Gly Gly Gly Gly Gly Ala Cys Thr Thr 
1               5                   10                  15      


Ala Thr Gly Cys Thr Cys Thr Thr Gly Ala Cys Thr Ala Cys 
            20                  25                  30  


<210>  85
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  85

Gln Leu Trp Gly Asn Tyr Ala Leu Asp Tyr 
1               5                   10  


<210>  86
<211>  30
<212>  PRT
<213>  Homo sapiens

<400>  86

Cys Ala Gly Thr Thr Ala Thr Gly Gly Gly Gly Gly Ala Ala Thr Thr 
1               5                   10                  15      


Ala Thr Gly Cys Thr Cys Thr Thr Gly Ala Cys Thr Ala Cys 
            20                  25                  30  


<210>  87
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  87

Gln Leu Trp Gly Tyr Tyr Ala Leu Asp Phe 
1               5                   10  


<210>  88
<211>  30
<212>  PRT
<213>  Homo sapiens

<400>  88

Cys Ala Gly Thr Thr Ala Thr Gly Gly Gly Gly Gly Thr Ala Cys Thr 
1               5                   10                  15      


Ala Thr Gly Cys Thr Cys Thr Thr Gly Ala Cys Thr Thr Thr 
            20                  25                  30  


<210>  89
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  89

Gln Leu Trp Gly Tyr Tyr Ala Leu Asp Ile 
1               5                   10  


<210>  90
<211>  30
<212>  PRT
<213>  Homo sapiens

<400>  90

Cys Ala Gly Thr Thr Ala Thr Gly Gly Gly Gly Gly Thr Ala Cys Thr 
1               5                   10                  15      


Ala Thr Gly Cys Thr Cys Thr Thr Gly Ala Cys Ala Thr Thr 
            20                  25                  30  


<210>  91
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  91

Gln Leu Trp Gly Tyr Tyr Ala Leu Asp Tyr 
1               5                   10  


<210>  92
<211>  30
<212>  PRT
<213>  Homo sapiens

<400>  92

Cys Ala Gly Thr Thr Ala Thr Gly Gly Gly Gly Gly Thr Ala Cys Thr 
1               5                   10                  15      


Ala Thr Gly Cys Thr Cys Thr Thr Gly Ala Cys Thr Ala Cys 
            20                  25                  30  


<210>  93
<211>  106
<212>  PRT
<213>  Homo sapiens

<400>  93

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr 
        35                  40                  45              


Asp Thr Ser Asn Leu Ala Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Val Tyr Tyr Cys Ser Gln Trp Ser Gly Tyr Pro Tyr Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  94
<211>  318
<212>  DNA
<213>  Homo sapiens

<400>  94
gaaattgtgt tgacacagtc tccagccacc ctgtctttgt ctccagggga aagagccacc       60

ctctcctgca gtgccagctc aagtgtaagt tacatgtact ggtaccaaca gaaacctggc      120

caggctccca ggctcctcat ctatgacaca tccaacctgg cttctggcat cccagccagg      180

ttcagtggca gtgggtctgg gacagacttc actctcacca tcagcagcct agagcctgaa      240

gattttgcag tttattactg ttctcagtgg agtggttacc catacacgtt cggcggaggg      300

accaaggtgg agatcaaa                                                    318


<210>  95
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  95

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Lys Ile Ser Ser Gly Gly Ser Tyr Thr Tyr Tyr Pro Asp Thr Val 
    50                  55                  60                  


Thr Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gln Leu Trp Gly Tyr Tyr Ala Leu Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser 
        115                 


<210>  96
<211>  357
<212>  DNA
<213>  Homo sapiens

<400>  96
gaggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttagt agctttgcca tgtcttgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtggccaaa attagtagtg gtgggagtta cacctactat      180

cctgacactg tgacgggccg attcaccatc tccagagaca acgccaagaa ctcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggctgtgt attactgtgc gagacagtta      300

tgggggtact atgctcttga ctactggggc caagggacca cggtcaccgt ctcctca         357


<210>  97
<211>  106
<212>  PRT
<213>  Homo sapiens

<400>  97

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Ser Ala Ser Ile Ser Val Ser Tyr Met 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr 
        35                  40                  45              


Asp Met Ser Asn Leu Ala Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Val Tyr Tyr Cys Met Gln Trp Ser Gly Tyr Pro Tyr Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  98
<211>  318
<212>  DNA
<213>  Homo sapiens

<400>  98
gaaattgtgt tgacacagtc tccagccacc ctgtctttgt ctccagggga aagagccacc       60

ctctcctgca gtgccagcat tagtgtaagt tacatgtact ggtaccaaca gaaacctggc      120

caggctccca ggctcctcat ctatgacatg tccaacctgg cttctggcat cccagccagg      180

ttcagtggca gtgggtctgg gacagacttc actctcacca tcagcagcct agagcctgaa      240

gattttgcag tttattactg tatgcagtgg agtggttacc catacacgtt cggcggaggg      300

accaaggtgg agatcaaa                                                    318


<210>  99
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  99

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Pro Phe 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Lys Ile Ser Pro Gly Gly Ser Trp Thr Tyr Tyr Ser Asp Thr Val 
    50                  55                  60                  


Thr Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gln Leu Trp Gly Tyr Tyr Ala Leu Asp Ile Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser 
        115                 


<210>  100
<211>  357
<212>  DNA
<213>  Homo sapiens

<400>  100
gaggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttagt ccttttgcca tgtcttgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtggccaaa attagtccgg gtgggagttg gacctactat      180

tctgacactg tgacgggccg attcaccatc tccagagaca acgccaagaa ctcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggctgtgt attactgtgc gagacagtta      300

tgggggtact atgctcttga catttggggc caagggacca cggtcaccgt ctcctca         357


<210>  101
<211>  90
<212>  PRT
<213>  Homo sapiens

<400>  101

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Ser Ala Ser Tyr Ser Val Ser Tyr Met 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr 
        35                  40                  45              


Asp Met Ser Asn Leu Ala Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Val Tyr Tyr Cys Met Gln Trp 
                85                  90  


<210>  102
<211>  318
<212>  DNA
<213>  Homo sapiens

<400>  102
gaaattgtgt tgacacagtc tccagccacc ctgtctttgt ctccagggga aagagccacc       60

ctctcctgca gtgccagcta tagtgtaagt tacatgtact ggtaccaaca gaaacctggc      120

caggctccca ggctcctcat ctatgacatg tccaacctgg cttctggcat cccagccagg      180

ttcagtggca gtgggtctgg gacagacttc actctcacca tcagcagcct agagcctgaa      240

gattttgcag tttattactg tatgcagtgg agtggttacc catacacgtt cggcggaggg      300

accaaggtgg agatcaaa                                                    318


<210>  103
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  103

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Gln Phe Ser Ser Phe 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Lys Ile Ser Pro Gly Gly Ser Tyr Thr Tyr Tyr Ser Asp Thr Val 
    50                  55                  60                  


Thr Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gln Leu Trp Gly Tyr Tyr Ala Leu Asp Phe Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser 
        115                 


<210>  104
<211>  357
<212>  DNA
<213>  Homo sapiens

<400>  104
gaggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt ccagtttagt agctttgcca tgtcttgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtggccaaa attagtccgg gtgggagtta cacctactat      180

tctgacactg tgacgggccg attcaccatc tccagagaca acgccaagaa ctcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggctgtgt attactgtgc gagacagtta      300

tgggggtact atgctcttga cttttggggc caagggacca cggtcaccgt ctcctca         357


<210>  105
<211>  23
<212>  PRT
<213>  Homo sapiens

<400>  105

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys 
            20              


<210>  106
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  106

Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  107
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  107

Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys 
            20                  25                  30          


<210>  108
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  108

Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
1               5                   10  


<210>  109
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  109

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser 
            20                  25  


<210>  110
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  110

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala 
1               5                   10                  


<210>  111
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  111

Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  112
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  112

Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
1               5                   10      


<210>  113
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  113

Glu Ile Ser Ser Gly Gly Ser Tyr Thr Tyr Tyr Pro Asp Thr Val Thr 
1               5                   10                  15      


Gly 
    


<210>  114
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  114

Gly Leu Trp Gly Tyr Tyr Ala Leu Asp Tyr 
1               5                   10  


<210>  115
<211>  212
<212>  PRT
<213>  Homo sapiens

<400>  115

Met Asn Ser Phe Ser Thr Ser Ala Phe Gly Pro Val Ala Phe Ser Leu 
1               5                   10                  15      


Gly Leu Leu Leu Val Leu Pro Ala Ala Phe Pro Ala Pro Val Pro Pro 
            20                  25                  30          


Gly Glu Asp Ser Lys Asp Val Ala Ala Pro His Arg Gln Pro Leu Thr 
        35                  40                  45              


Ser Ser Glu Arg Ile Asp Lys Gln Ile Arg Tyr Ile Leu Asp Gly Ile 
    50                  55                  60                  


Ser Ala Leu Arg Lys Glu Thr Cys Asn Lys Ser Asn Met Cys Glu Ser 
65                  70                  75                  80  


Ser Lys Glu Ala Leu Ala Glu Asn Asn Leu Asn Leu Pro Lys Met Ala 
                85                  90                  95      


Glu Lys Asp Gly Cys Phe Gln Ser Gly Phe Asn Glu Glu Thr Cys Leu 
            100                 105                 110         


Val Lys Ile Ile Thr Gly Leu Leu Glu Phe Glu Val Tyr Leu Glu Tyr 
        115                 120                 125             


Leu Gln Asn Arg Phe Glu Ser Ser Glu Glu Gln Ala Arg Ala Val Gln 
    130                 135                 140                 


Met Ser Thr Lys Val Leu Ile Gln Phe Leu Gln Lys Lys Ala Lys Asn 
145                 150                 155                 160 


Leu Asp Ala Ile Thr Thr Pro Asp Pro Thr Thr Asn Ala Ser Leu Leu 
                165                 170                 175     


Thr Lys Leu Gln Ala Gln Asn Gln Trp Leu Gln Asp Met Thr Thr His 
            180                 185                 190         


Leu Ile Leu Arg Ser Phe Lys Glu Phe Leu Gln Ser Ser Leu Arg Ala 
        195                 200                 205             


Leu Arg Gln Met 
    210         


<210>  116
<211>  106
<212>  PRT
<213>  Homo sapiens

<400>  116

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr 
        35                  40                  45              


Asp Thr Ser Asn Leu Ala Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Val Tyr Tyr Cys Ser Gln Trp Ser Gly Tyr Pro Tyr Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  117
<211>  378
<212>  DNA
<213>  Homo sapiens

<400>  117
atggaagccc cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccgga       60

gaaattgtgt tgacacagtc tccagccacc ctgtctttgt ctccagggga aagagccacc      120

ctctcctgca gtgccagctc aagtgtaagt tacatgtact ggtaccaaca gaaacctggc      180

caggctccca ggctcctcat ctatgacaca tccaacctgg cttctggcat cccagccagg      240

ttcagtggca gtgggtctgg gacagacttc actctcacca tcagcagcct agagcctgaa      300

gattttgcag tttattactg ttctcagtgg agtggttacc catacacgtt cggcggaggg      360

accaaggtgg agatcaaa                                                    378


<210>  118
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  118

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Lys Ile Ser Pro Gly Gly Ser Tyr Thr Tyr Tyr Pro Asp Thr Val 
    50                  55                  60                  


Thr Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gln Leu Trp Gly Tyr Tyr Ala Leu Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser 
        115                 


<210>  119
<211>  414
<212>  DNA
<213>  Homo sapiens

<400>  119
atggagtttg gcctgagctg ggttttcctt gttgctattt tagaaggtgt ccagtgtgag       60

gtgcagctgg tggagtctgg gggaggcttg gtccagcctg gggggtccct gagactctcc      120

tgtgcagcct ctggattcac ctttagtagc tttgccatgt cttgggtccg ccaggctcca      180

gggaaggggc tggagtgggt ggccaaaatt agtcccggtg ggagttacac ctactatcct      240

gacactgtga cgggccgatt caccatctcc agagacaacg ccaagaactc actgtatctg      300

caaatgaaca gcctgagagc cgaggacacg gctgtgtatt actgtgcgag acagttatgg      360

gggtactatg ctcttgacta ctggggccaa gggaccacgg tcaccgtctc ctca            414


<210>  120
<211>  106
<212>  PRT
<213>  Homo sapiens

<400>  120

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr 
        35                  40                  45              


Asp Phe Ser Asn Leu Ala Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Val Tyr Tyr Cys Met Gln Trp Ser Gly Tyr Pro Tyr Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  121
<211>  378
<212>  DNA
<213>  Homo sapiens

<400>  121
atggaagccc cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccgga       60

gaaattgtgt tgacacagtc tccagccacc ctgtctttgt ctccagggga aagagccacc      120

ctctcctgca gtgccagctc aagtgtaagt tacatgtact ggtaccaaca gaaacctggc      180

caggctccca ggctcctcat ctatgacttc tccaacctgg cttctggcat cccagccagg      240

ttcagtggca gtgggtctgg gacagacttc actctcacca tcagcagcct agagcctgaa      300

gattttgcag tttattactg tatgcagtgg agtggttacc catacacgtt cggcggaggg      360

accaaggtgg agatcaaa                                                    378


<210>  122
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  122

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Gln Phe Ser Pro Phe 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Lys Ile Ser Pro Gly Gly Ser Trp Thr Tyr Tyr Ser Asp Thr Val 
    50                  55                  60                  


Thr Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gln Leu Trp Gly Tyr Tyr Ala Leu Asp Ile Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser 
        115                 


<210>  123
<211>  414
<212>  DNA
<213>  Homo sapiens

<400>  123
atggagtttg gcctgagctg ggttttcctt gttgctattt tagaaggtgt ccagtgtgag       60

gtgcagctgg tggagtctgg gggaggcttg gtccagcctg gggggtccct gagactctcc      120

tgtgcagcct ctggattcca gtttagtccc tttgccatgt cttgggtccg ccaggctcca      180

gggaaggggc tggagtgggt ggccaaaatt agtcccggtg ggagttggac ctactatagc      240

gacactgtga cgggccgatt caccatctcc agagacaacg ccaagaactc actgtatctg      300

caaatgaaca gcctgagagc cgaggacacg gctgtgtatt actgtgcgag acagttatgg      360

gggtactatg ctcttgacat ttggggccaa gggaccacgg tcaccgtctc ctca            414


<210>  124
<211>  106
<212>  PRT
<213>  Homo sapiens

<400>  124

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Ser Ala Ser Ile Ser Val Ser Tyr Met 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr 
        35                  40                  45              


Asp Met Ser Asn Leu Ala Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Val Tyr Tyr Cys Met Gln Trp Ser Gly Tyr Pro Tyr Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  125
<211>  378
<212>  DNA
<213>  Homo sapiens

<400>  125
atggaagccc cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccgga       60

gaaattgtgt tgacacagtc tccagccacc ctgtctttgt ctccagggga aagagccacc      120

ctctcctgca gtgccagcat tagtgtaagt tacatgtact ggtaccaaca gaaacctggc      180

caggctccca ggctcctcat ctatgacatg tccaacctgg cttctggcat cccagccagg      240

ttcagtggca gtgggtctgg gacagacttc actctcacca tcagcagcct agagcctgaa      300

gattttgcag tttattactg tatgcagtgg agtggttacc catacacgtt cggcggaggg      360

accaaggtgg agatcaaa                                                    378


<210>  126
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  126

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Gln Phe Ser Ser Phe 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Lys Ile Ser Pro Gly Gly Ser Tyr Thr Tyr Tyr Ser Asp Thr Val 
    50                  55                  60                  


Thr Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gln Leu Trp Gly Tyr Tyr Ala Leu Asp Ile Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser 
        115                 


<210>  127
<211>  414
<212>  DNA
<213>  Homo sapiens

<400>  127
atggagtttg gcctgagctg ggttttcctt gttgctattt tagaaggtgt ccagtgtgag       60

gtgcagctgg tggagtctgg gggaggcttg gtccagcctg gggggtccct gagactctcc      120

tgtgcagcct ctggattcca gtttagtagc tttgccatgt cttgggtccg ccaggctcca      180

gggaaggggc tggagtgggt ggccaaaatt agtcccggtg ggagttacac ctactatagc      240

gacactgtga cgggccgatt caccatctcc agagacaacg ccaagaactc actgtatctg      300

caaatgaaca gcctgagagc cgaggacacg gctgtgtatt actgtgcgag acagttatgg      360

gggtactatg ctcttgacat ttggggccaa gggaccacgg tcaccgtctc ctca            414


<210>  128
<211>  106
<212>  PRT
<213>  Homo sapiens

<400>  128

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Ser Ala Ser Tyr Ser Val Ser Tyr Met 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr 
        35                  40                  45              


Asp Phe Ser Asn Leu Ala Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Val Tyr Tyr Cys Met Gln Trp Ser Gly Tyr Pro Tyr Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  129
<211>  378
<212>  DNA
<213>  Homo sapiens

<400>  129
atggaagccc cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccgga       60

gaaattgtgt tgacacagtc tccagccacc ctgtctttgt ctccagggga aagagccacc      120

ctctcctgca gtgccagcta cagtgtaagt tacatgtact ggtaccaaca gaaacctggc      180

caggctccca ggctcctcat ctatgacttc tccaacctgg cttctggcat cccagccagg      240

ttcagtggca gtgggtctgg gacagacttc actctcacca tcagcagcct agagcctgaa      300

gattttgcag tttattactg tatgcagtgg agtggttacc catacacgtt cggcggaggg      360

accaaggtgg agatcaaa                                                    378


<210>  130
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  130

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Gln Phe Ser Pro Phe 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Lys Ile Ser Pro Gly Gly Ser Trp Thr Tyr Tyr Pro Asp Thr Asp 
    50                  55                  60                  


Thr Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gln Leu Trp Gly Tyr Tyr Ala Leu Asp Phe Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser 
        115                 


<210>  131
<211>  414
<212>  DNA
<213>  Homo sapiens

<400>  131
atggagtttg gcctgagctg ggttttcctt gttgctattt tagaaggtgt ccagtgtgag       60

gtgcagctgg tggagtctgg gggaggcttg gtccagcctg gggggtccct gagactctcc      120

tgtgcagcct ctggattcca gtttagtccc tttgccatgt cttgggtccg ccaggctcca      180

gggaaggggc tggagtgggt ggccaaaatt agtcccggtg ggagttggac ctactatcct      240

gacactgaca cgggccgatt caccatctcc agagacaacg ccaagaactc actgtatctg      300

caaatgaaca gcctgagagc cgaggacacg gctgtgtatt actgtgcgag acagttatgg      360

gggtactatg ctcttgactt ctggggccaa gggaccacgg tcaccgtctc ctca            414


<210>  132
<211>  10
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (2)..(5)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa can be any naturally occurring amino acid

<400>  132

Ser Xaa Xaa Xaa Xaa Val Xaa Tyr Met Tyr 
1               5                   10  


<210>  133
<211>  7
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa can be any naturally occurring amino acid

<400>  133

Asp Xaa Ser Xaa Leu Xaa Ser 
1               5           


<210>  134
<211>  9
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  Xaa can be any naturally occurring amino acid

<400>  134

Xaa Xaa Trp Ser Gly Tyr Pro Tyr Thr 
1               5                   


<210>  135
<211>  10
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa can be any naturally occurring amino acid

<400>  135

Gly Phe Xaa Xaa Ser Xaa Phe Ala Xaa Ser 
1               5                   10  


<210>  136
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (15)..(17)
<223>  Xaa can be any naturally occurring amino acid

<400>  136

Lys Xaa Ser Xaa Gly Gly Ser Xaa Xaa Tyr Xaa Xaa Asp Thr Xaa Xaa 
1               5                   10                  15      


Xaa 
    


<210>  137
<211>  10
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Xaa can be any naturally occurring amino acid

<400>  137

Gln Leu Trp Gly Xaa Tyr Ala Leu Asp Xaa 
1               5                   10  


<210>  138
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  138

Gln Gln Trp Ser Gly Tyr Pro Tyr Thr 
1               5                   


<210>  139
<211>  119
<212>  PRT
<213>  Mus musculus

<400>  139

Glu Val Gln Leu Val Glu Ser Gly Gly Lys Leu Leu Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          


Ala Met Ser Trp Phe Arg Gln Ser Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Glu Ile Ser Ser Gly Gly Ser Tyr Thr Tyr Tyr Pro Asp Thr Val 
    50                  55                  60                  


Thr Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Glu Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Leu Trp Gly Tyr Tyr Ala Leu Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Ser Val Thr Val Ser Ser 
        115                 


<210>  140
<211>  106
<212>  PRT
<213>  Mus musculus

<400>  140

Gln Ile Val Leu Ile Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Arg Leu Leu Ile Tyr 
        35                  40                  45              


Asp Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Gly Tyr Pro Tyr Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  141
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  141

Ser Phe Ala Met Ser 
1               5   


<210>  142
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  142

Glu Ile Ser Ser Gly Gly Ser Tyr Thr Tyr Tyr Pro Asp Thr Val Thr 
1               5                   10                  15      


Gly 
    


<210>  143
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  143

Gly Leu Trp Gly Tyr Tyr Ala Leu Asp Tyr 
1               5                   10  


<210>  144
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  144

Ser Ala Ser Ser Ser Val Ser Tyr Met Tyr 
1               5                   10  


<210>  145
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  145

Asp Thr Ser Asn Leu Ala Ser 
1               5           


<210>  146
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  146

Gln Gln Trp Ser Gly Tyr Pro Tyr Thr 
1               5                   


