                         SEQUENCE LISTING

<110>  Merial, Inc.
       Fischer, Laurent
 
<120>  HEARTWORM VACCINE, METHODS AND USES THEREOF

<130>  MER 16-298.P1

<150>  62/319,731
<151>  2016-04-07

<160>  58    

<170>  PatentIn version 3.5

<210>  1
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Murine IgK chain leader

<400>  1

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp 
            20      


<210>  2
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-myc tag

<400>  2

Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
1               5                   10  


<210>  3
<211>  361
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Serpin segment of SSFI chimera

<400>  3

Thr Asp His Ala Gln Phe Asn Phe Thr Val Ser Leu Leu Gln Lys Val 
1               5                   10                  15      


Ala Gln Lys Asp Lys Ser Ile Ile Leu Ser Pro Leu Ser Val Ser Thr 
            20                  25                  30          


Ser Leu Phe Met Ile Tyr Leu Ala Ala Asp Gly Lys Thr Lys Gln Gln 
        35                  40                  45              


Leu Glu Asp Val Leu Gly Gly Thr Ala Ser Thr Glu Glu Val Arg Leu 
    50                  55                  60                  


His Phe Ala Lys Leu Leu Ala Thr Asn Glu Asn Val Glu Asn Glu Asn 
65                  70                  75                  80  


Tyr Thr Leu Arg Leu Ala Asn Arg Phe Tyr Val Arg Gln Glu Phe Arg 
                85                  90                  95      


Thr Lys Glu Ser Phe Thr Arg Thr Leu Gln Tyr Tyr Tyr Asn Glu Lys 
            100                 105                 110         


Leu Tyr Asn Phe Asn Tyr Gly Glu Lys Tyr Lys Phe Val Gln Glu Ile 
        115                 120                 125             


Asn Lys Trp Ile Ser Gly Lys Thr Asn Asn Lys Ile Thr Glu Leu Ile 
    130                 135                 140                 


Thr Ala Asp Ser Val Ser Asp Asp Ile Lys Met Leu Leu Leu Asn Ala 
145                 150                 155                 160 


Ile His Phe Ser Gly Thr Trp Glu Thr Gln Phe Met Lys Asp Val Thr 
                165                 170                 175     


Lys Gln Lys Asp Phe Tyr Ile Ser Glu His Lys Thr Lys Lys Val Pro 
            180                 185                 190         


Met Met Met Thr Thr Tyr Ala Ile Pro Tyr Phe Glu Asp Asp Phe Val 
        195                 200                 205             


Gln Val Val Lys Met Pro Tyr Val Gly Asn Glu Ile Glu Met Val Phe 
    210                 215                 220                 


Ile Leu Pro Lys Ile Arg Tyr Gly Leu Ser Asn Val Leu Gln Asn Leu 
225                 230                 235                 240 


Thr Gly Ser Asp Leu Val Arg Tyr Ile His Asn Ala Lys Pro Thr Leu 
                245                 250                 255     


Ser Ser Leu Lys Ile Pro Arg Phe Glu Leu Lys Gly Lys Leu Asn Leu 
            260                 265                 270         


Lys Lys Thr Leu Ala Asn Ile Gly Ile Thr Asp Ala Phe Ser Arg Ala 
        275                 280                 285             


Ala Asn Phe Lys Glu Leu Thr Asn Asp Glu Ile Ser Val Gly Ser Ile 
    290                 295                 300                 


Ile His Ala Gly Phe Ile Ala Val Asp Glu Lys Gly Thr Glu Ser Ala 
305                 310                 315                 320 


Ala Ala Thr Lys Val Glu Leu Ile Asp Arg Ile Ser Ala Val Lys Tyr 
                325                 330                 335     


Phe His Ala Asp Gln Pro Phe Leu Phe Ala Ile Val Arg Gly Leu Lys 
            340                 345                 350         


Thr Ile Leu Phe Ala Gly Gln Phe Ala 
        355                 360     


<210>  4
<211>  235
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Syntenin segment of SSFI chimera

<400>  4

Pro Leu Tyr Pro Thr Phe Glu Asp Leu Leu Val Asp Gln Tyr His Tyr 
1               5                   10                  15      


Glu Gln Tyr Asp Asn Tyr Ser Ser His Asp Ser Pro Pro Val His Ser 
            20                  25                  30          


Tyr Ala Lys Pro Ser Ala Pro Leu Tyr Asp Ser Ser Ser Ser Thr Ile 
        35                  40                  45              


Ser Ala Gly Arg Ile Tyr Glu Ala Ile Asp Glu Asn Thr Val Ser Pro 
    50                  55                  60                  


Val Leu Ser Lys Met Ser Gly Tyr Pro Ala Leu Pro Ser Tyr Tyr Glu 
65                  70                  75                  80  


Ser Ile Ser Gln Pro Gln His Ala Ser Thr Leu Lys Leu Ser Glu Gln 
                85                  90                  95      


Leu Pro Glu Val Arg Leu Pro Asn Leu His Leu Pro Gln Ser Ile Ala 
            100                 105                 110         


Val Gln Pro Tyr Met Ser Asn Arg Leu Val Ser Leu Glu Asn Asp Trp 
        115                 120                 125             


Ile Ile Ala Pro Ile Thr Leu Gln Cys Pro Gly Leu Ala Lys Thr Asn 
    130                 135                 140                 


Leu Thr His Gly Val Arg Lys Val Ile Leu Asn Arg Thr Lys Asp Lys 
145                 150                 155                 160 


Lys Tyr Gly Leu Arg Met Arg Ala Val Asn Gln Gly Val Phe Val Gln 
                165                 170                 175     


Leu Val Ala Glu Gly Ser Pro Ala Ala Ala Ala Gly Ile Arg Phe Gly 
            180                 185                 190         


Asp Gln Leu Leu Asn Leu Asn Gly Thr Glu Val Leu Gly Met Thr Gly 
        195                 200                 205             


Gln Lys Ala Met Asp Ile Met Lys Lys Ser Lys Arg Glu Val Ile Leu 
    210                 215                 220                 


Ile Leu Arg Asp Arg Pro Leu Ala Arg Thr Ile 
225                 230                 235 


<210>  5
<211>  333
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fukutin segment of SSFI chimera

<400>  5

Asn His Thr Glu Glu Val Thr Lys Tyr Ile Ala Val Thr Asp Lys Phe 
1               5                   10                  15      


Ser Asn Ile Thr Tyr Ser Asn Phe His Leu Glu Lys Lys Glu Leu Leu 
            20                  25                  30          


Tyr Leu Lys Gln Phe Tyr His Leu Phe Trp Leu Pro Gly Ile Asn Pro 
        35                  40                  45              


Ser Lys Tyr Ile Phe Gly Thr Tyr Asp Asn Ser Lys Asn Leu Leu Ala 
    50                  55                  60                  


Ile Gly Asn Ile Ile Ile Tyr Arg Met Val Asn Ser Ser Asn Glu Asp 
65                  70                  75                  80  


Tyr Val Arg Phe Val Tyr Asp Glu Asp His Arg Ala Ala Tyr Gly Leu 
                85                  90                  95      


His Ala Val Lys Lys His Ile Phe Glu Arg Glu Thr Trp Val Pro Val 
            100                 105                 110         


Asn Lys Glu Glu Phe Leu Arg Lys Trp Ser Ser Gly Arg Phe Leu Asp 
        115                 120                 125             


Cys Ile Arg Leu Asn Ile Ser Thr Ser Trp Thr Lys Ser Val Ile Pro 
    130                 135                 140                 


His Ser Tyr Val Asn Asn Met Ala Thr Phe Arg Asp Phe Ile Glu Ser 
145                 150                 155                 160 


Phe Lys Ala Ile Pro Phe Leu Phe Gly Gly Thr Leu Leu Gly Trp Tyr 
                165                 170                 175     


Arg Glu Cys Ser Phe Ile Lys Asp Thr Thr Asp Val Asp Met Ala Met 
            180                 185                 190         


Lys Ile Thr Ser Leu Asp Leu Arg Met Leu Lys Asn Met Glu Lys Ser 
        195                 200                 205             


Asn Asp Phe Arg Leu Phe Trp Ile Leu Gly Lys Ile Asn Asp Ser Leu 
    210                 215                 220                 


Glu Val Ser Val Tyr Ser Ala Asn Ile Lys Ile Asp Leu Phe Phe Leu 
225                 230                 235                 240 


Tyr Glu Asn Lys Asp Phe Ala Trp Val Gly Gly Met Ile Val Ser Lys 
                245                 250                 255     


Arg Lys Lys Phe Arg Trp Val Tyr Pro Pro Ile Ser Gln Ile Cys Thr 
            260                 265                 270         


Gly Asp Leu Leu Gly Arg Leu Phe His Val Pro Cys Asn Val Glu Glu 
        275                 280                 285             


Val Leu Lys Ala Asp Tyr Gly Asp Trp Arg Ile Pro Tyr Pro Thr Ala 
    290                 295                 300                 


Asn Phe Thr Trp Tyr Lys Thr His Lys Asn Ile His Glu Ala Gly Tyr 
305                 310                 315                 320 


Trp Ser Glu Asn Glu Trp Asn Asp Thr Tyr Lys Ile Phe 
                325                 330             


<210>  6
<211>  88
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IF1 segment of SSFI chimera

<400>  6

Val Lys Asp Glu Lys Ser Lys Thr Leu Phe Glu Val Glu Gly Ala Val 
1               5                   10                  15      


Thr Ala Leu Leu Pro Ala Ala Glu Phe Arg Val Lys Leu Asp Asn Glu 
            20                  25                  30          


His Glu Ile Ile Cys His Val Ser Gly Lys Val Arg Arg Ser Lys Ile 
        35                  40                  45              


Arg Ile Ile Ile Gly Asp Arg Val Leu Val Glu Met Ser Ile Tyr Asp 
    50                  55                  60                  


Arg Asn Ala Lys Lys Gly Arg Ile Ile Arg Arg Leu Lys Gly Thr Ser 
65                  70                  75                  80  


Asp Arg Thr Ile Ser Lys Glu Gln 
                85              


<210>  7
<211>  1058
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SSFI Chimera with 5' Murine IgK chain leader and 3' C-myc tag

<400>  7

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Thr Asp His Ala Gln Phe Asn Phe Thr Val Ser 
            20                  25                  30          


Leu Leu Gln Lys Val Ala Gln Lys Asp Lys Ser Ile Ile Leu Ser Pro 
        35                  40                  45              


Leu Ser Val Ser Thr Ser Leu Phe Met Ile Tyr Leu Ala Ala Asp Gly 
    50                  55                  60                  


Lys Thr Lys Gln Gln Leu Glu Asp Val Leu Gly Gly Thr Ala Ser Thr 
65                  70                  75                  80  


Glu Glu Val Arg Leu His Phe Ala Lys Leu Leu Ala Thr Asn Glu Asn 
                85                  90                  95      


Val Glu Asn Glu Asn Tyr Thr Leu Arg Leu Ala Asn Arg Phe Tyr Val 
            100                 105                 110         


Arg Gln Glu Phe Arg Thr Lys Glu Ser Phe Thr Arg Thr Leu Gln Tyr 
        115                 120                 125             


Tyr Tyr Asn Glu Lys Leu Tyr Asn Phe Asn Tyr Gly Glu Lys Tyr Lys 
    130                 135                 140                 


Phe Val Gln Glu Ile Asn Lys Trp Ile Ser Gly Lys Thr Asn Asn Lys 
145                 150                 155                 160 


Ile Thr Glu Leu Ile Thr Ala Asp Ser Val Ser Asp Asp Ile Lys Met 
                165                 170                 175     


Leu Leu Leu Asn Ala Ile His Phe Ser Gly Thr Trp Glu Thr Gln Phe 
            180                 185                 190         


Met Lys Asp Val Thr Lys Gln Lys Asp Phe Tyr Ile Ser Glu His Lys 
        195                 200                 205             


Thr Lys Lys Val Pro Met Met Met Thr Thr Tyr Ala Ile Pro Tyr Phe 
    210                 215                 220                 


Glu Asp Asp Phe Val Gln Val Val Lys Met Pro Tyr Val Gly Asn Glu 
225                 230                 235                 240 


Ile Glu Met Val Phe Ile Leu Pro Lys Ile Arg Tyr Gly Leu Ser Asn 
                245                 250                 255     


Val Leu Gln Asn Leu Thr Gly Ser Asp Leu Val Arg Tyr Ile His Asn 
            260                 265                 270         


Ala Lys Pro Thr Leu Ser Ser Leu Lys Ile Pro Arg Phe Glu Leu Lys 
        275                 280                 285             


Gly Lys Leu Asn Leu Lys Lys Thr Leu Ala Asn Ile Gly Ile Thr Asp 
    290                 295                 300                 


Ala Phe Ser Arg Ala Ala Asn Phe Lys Glu Leu Thr Asn Asp Glu Ile 
305                 310                 315                 320 


Ser Val Gly Ser Ile Ile His Ala Gly Phe Ile Ala Val Asp Glu Lys 
                325                 330                 335     


Gly Thr Glu Ser Ala Ala Ala Thr Lys Val Glu Leu Ile Asp Arg Ile 
            340                 345                 350         


Ser Ala Val Lys Tyr Phe His Ala Asp Gln Pro Phe Leu Phe Ala Ile 
        355                 360                 365             


Val Arg Gly Leu Lys Thr Ile Leu Phe Ala Gly Gln Phe Ala Gly Ser 
    370                 375                 380                 


Ser Gly Pro Leu Tyr Pro Thr Phe Glu Asp Leu Leu Val Asp Gln Tyr 
385                 390                 395                 400 


His Tyr Glu Gln Tyr Asp Asn Tyr Ser Ser His Asp Ser Pro Pro Val 
                405                 410                 415     


His Ser Tyr Ala Lys Pro Ser Ala Pro Leu Tyr Asp Ser Ser Ser Ser 
            420                 425                 430         


Thr Ile Ser Ala Gly Arg Ile Tyr Glu Ala Ile Asp Glu Asn Thr Val 
        435                 440                 445             


Ser Pro Val Leu Ser Lys Met Ser Gly Tyr Pro Ala Leu Pro Ser Tyr 
    450                 455                 460                 


Tyr Glu Ser Ile Ser Gln Pro Gln His Ala Ser Thr Leu Lys Leu Ser 
465                 470                 475                 480 


Glu Gln Leu Pro Glu Val Arg Leu Pro Asn Leu His Leu Pro Gln Ser 
                485                 490                 495     


Ile Ala Val Gln Pro Tyr Met Ser Asn Arg Leu Val Ser Leu Glu Asn 
            500                 505                 510         


Asp Trp Ile Ile Ala Pro Ile Thr Leu Gln Cys Pro Gly Leu Ala Lys 
        515                 520                 525             


Thr Asn Leu Thr His Gly Val Arg Lys Val Ile Leu Asn Arg Thr Lys 
    530                 535                 540                 


Asp Lys Lys Tyr Gly Leu Arg Met Arg Ala Val Asn Gln Gly Val Phe 
545                 550                 555                 560 


Val Gln Leu Val Ala Glu Gly Ser Pro Ala Ala Ala Ala Gly Ile Arg 
                565                 570                 575     


Phe Gly Asp Gln Leu Leu Asn Leu Asn Gly Thr Glu Val Leu Gly Met 
            580                 585                 590         


Thr Gly Gln Lys Ala Met Asp Ile Met Lys Lys Ser Lys Arg Glu Val 
        595                 600                 605             


Ile Leu Ile Leu Arg Asp Arg Pro Leu Ala Arg Thr Ile Gly Ser Ser 
    610                 615                 620                 


Gly Asn His Thr Glu Glu Val Thr Lys Tyr Ile Ala Val Thr Asp Lys 
625                 630                 635                 640 


Phe Ser Asn Ile Thr Tyr Ser Asn Phe His Leu Glu Lys Lys Glu Leu 
                645                 650                 655     


Leu Tyr Leu Lys Gln Phe Tyr His Leu Phe Trp Leu Pro Gly Ile Asn 
            660                 665                 670         


Pro Ser Lys Tyr Ile Phe Gly Thr Tyr Asp Asn Ser Lys Asn Leu Leu 
        675                 680                 685             


Ala Ile Gly Asn Ile Ile Ile Tyr Arg Met Val Asn Ser Ser Asn Glu 
    690                 695                 700                 


Asp Tyr Val Arg Phe Val Tyr Asp Glu Asp His Arg Ala Ala Tyr Gly 
705                 710                 715                 720 


Leu His Ala Val Lys Lys His Ile Phe Glu Arg Glu Thr Trp Val Pro 
                725                 730                 735     


Val Asn Lys Glu Glu Phe Leu Arg Lys Trp Ser Ser Gly Arg Phe Leu 
            740                 745                 750         


Asp Cys Ile Arg Leu Asn Ile Ser Thr Ser Trp Thr Lys Ser Val Ile 
        755                 760                 765             


Pro His Ser Tyr Val Asn Asn Met Ala Thr Phe Arg Asp Phe Ile Glu 
    770                 775                 780                 


Ser Phe Lys Ala Ile Pro Phe Leu Phe Gly Gly Thr Leu Leu Gly Trp 
785                 790                 795                 800 


Tyr Arg Glu Cys Ser Phe Ile Lys Asp Thr Thr Asp Val Asp Met Ala 
                805                 810                 815     


Met Lys Ile Thr Ser Leu Asp Leu Arg Met Leu Lys Asn Met Glu Lys 
            820                 825                 830         


Ser Asn Asp Phe Arg Leu Phe Trp Ile Leu Gly Lys Ile Asn Asp Ser 
        835                 840                 845             


Leu Glu Val Ser Val Tyr Ser Ala Asn Ile Lys Ile Asp Leu Phe Phe 
    850                 855                 860                 


Leu Tyr Glu Asn Lys Asp Phe Ala Trp Val Gly Gly Met Ile Val Ser 
865                 870                 875                 880 


Lys Arg Lys Lys Phe Arg Trp Val Tyr Pro Pro Ile Ser Gln Ile Cys 
                885                 890                 895     


Thr Gly Asp Leu Leu Gly Arg Leu Phe His Val Pro Cys Asn Val Glu 
            900                 905                 910         


Glu Val Leu Lys Ala Asp Tyr Gly Asp Trp Arg Ile Pro Tyr Pro Thr 
        915                 920                 925             


Ala Asn Phe Thr Trp Tyr Lys Thr His Lys Asn Ile His Glu Ala Gly 
    930                 935                 940                 


Tyr Trp Ser Glu Asn Glu Trp Asn Asp Thr Tyr Lys Ile Phe Gly Ser 
945                 950                 955                 960 


Ser Gly Val Lys Asp Glu Lys Ser Lys Thr Leu Phe Glu Val Glu Gly 
                965                 970                 975     


Ala Val Thr Ala Leu Leu Pro Ala Ala Glu Phe Arg Val Lys Leu Asp 
            980                 985                 990         


Asn Glu His Glu Ile Ile Cys His  Val Ser Gly Lys Val  Arg Arg Ser 
        995                 1000                 1005             


Lys Ile  Arg Ile Ile Ile Gly  Asp Arg Val Leu Val  Glu Met Ser 
    1010                 1015                 1020             


Ile Tyr  Asp Arg Asn Ala Lys  Lys Gly Arg Ile Ile  Arg Arg Leu 
    1025                 1030                 1035             


Lys Gly  Thr Ser Asp Arg Thr  Ile Ser Lys Glu Gln  Lys Leu Ile 
    1040                 1045                 1050             


Ser Glu  Glu Asp Leu 
    1055             


<210>  8
<211>  1083
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Serpin segment of SSFI chimera

<400>  8
acggatcatg cacagttcaa cttcacggtg agcctcctcc agaaagtcgc acagaaggac       60

aagagtatca tactgtcccc actttctgtt agtacttcgc tgttcatgat ctacctagca      120

gctgacggca agactaagca gcaactggag gacgtattag gtggtactgc atctaccgag      180

gaggtccgct tgcacttcgc caaactgctc gccaccaatg agaacgttga aaacgagaac      240

tacacactca ggctcgctaa tcgattttat gtcagacagg agttccgtac caaggagtcc      300

tttactagaa ccttgcaata ctactacaac gagaaactct acaacttcaa ttatggcgag      360

aaatacaagt tcgtccagga aatcaacaag tggattagcg gtaaaactaa taacaagatt      420

acggaattga taaccgcgga ttccgtttca gacgacatca agatgctcct gctaaacgct      480

atccactttt ccggtacttg ggagactcaa tttatgaaag atgtcaccaa gcagaaagat      540

ttctacatct cggaacacaa gaccaagaag gtgcctatga tgatgacgac ctacgccata      600

ccatatttcg aggacgactt tgtgcaagtg gtgaagatgc catacgtggg aaacgagatc      660

gaaatggttt tcattttacc gaagatcaga tatggcttgt ccaacgtcct gcaaaactta      720

acgggatctg acctggtgcg ctacattcac aatgcgaagc ctaccctgtc gagcttgaag      780

atacctaggt tcgagctgaa gggcaagctg aatctcaaga aaaccttggc taatataggc      840

attactgacg ccttctctcg tgctgccaac ttcaaagagc ttacaaacga cgaaatttca      900

gtgggctcga tcattcatgc aggattcatc gctgtggatg agaagggtac cgagtcagcc      960

gcggcaacaa aagtcgagct catagacagg atcagcgccg taaagtactt ccacgcggat     1020

caaccattcc tattcgctat tgtccgagga ctaaagacaa tcttatttgc cggtcaattc     1080

gct                                                                   1083


<210>  9
<211>  705
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Syntenin segment of SSFI chimera

<400>  9
cctctttatc ccactttcga ggatctgctg gtcgaccagt atcactacga acagtacgac       60

aactacagca gccatgatag cccacccgtt cattcctatg caaaacccag tgccccactt      120

tacgactcaa gctcatctac catttccgct ggccgtattt acgaagcgat agatgagaac      180

accgtgagtc ctgtcctgag caaaatgagc ggttaccctg ctctcccgtc atactacgaa      240

tcaatctcac aacctcaaca tgcctctaca ctgaaattgt cggagcaact cccagaagtc      300

agattaccca atttgcattt gccacagtct attgcggtac agccgtatat gtcaaaccgt      360

cttgtcagct tggaaaacga ttggatcatc gctccgataa cactccagtg tcccggcctg      420

gccaagacaa atctcaccca cggtgttcgt aaggttatcc tcaatagaac caaagacaag      480

aagtatggac tgcgtatgag ggcggtaaac caaggcgtat tcgtacagct ggtcgcagaa      540

ggttctcccg cagctgcggc gggcatccgt ttcggtgacc agcttctgaa cttgaatggt      600

actgaagtac taggcatgac tggacagaaa gcaatggaca ttatgaagaa gagcaagcgc      660

gaggtgattc ttatcctgag ggatcgtcct ctagcccgca ctatt                      705


<210>  10
<211>  999
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Fukutin segment of SSFI chimera

<400>  10
aatcacaccg aagaggtgac aaaatacatt gctgtgacgg ataagttcag caacatcact       60

tactccaact ttcacctgga gaagaaagag cttttgtatc tgaaacaatt ttaccatttg      120

ttctggctac ccggtataaa tccctctaaa tacattttcg gcacatacga caactccaag      180

aacttgctgg caataggaaa cataatcatc tatcgcatgg tgaattcctc caatgaggac      240

tacgtgcgat tcgtatacga cgaagatcac cgcgctgctt acggactcca cgccgttaag      300

aagcacatct ttgagagaga aacctgggta cctgtgaaca aggaagagtt cctaaggaag      360

tggtcatctg gaaggttcct ggattgcatt cgcctaaata tcagtacgag ctggaccaaa      420

agcgtcatcc cgcactccta cgtaaacaat atggctacat tcagagactt catcgaatcc      480

ttcaaggcta tcccctttct tttcggtggt actctgctcg gatggtatcg tgagtgttcg      540

tttatcaagg acaccacaga cgtcgacatg gcgatgaaaa ttacctccct ggacctccgc      600

atgttgaaga acatggagaa gagtaacgac ttccgcctct tttggatctt gggcaagatt      660

aacgatagtt tggaagtgtc ggtttacagt gccaacatta agatcgatct tttcttcttg      720

tacgaaaaca aagacttcgc ctgggttggc ggaatgattg tgtctaaacg caagaaattc      780

agatgggtct atccaccaat ctctcagatt tgcacaggag atctgttagg tcgccttttc      840

cacgtcccgt gcaacgtaga ggaagtgttg aaggccgatt acggtgattg gcgtatccct      900

tatcctacag ccaacttcac gtggtacaaa acgcacaaga acatccatga ggctggatac      960

tggtcagaaa acgaatggaa cgatacatac aagatcttt                             999


<210>  11
<211>  258
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IF1 segment of SSFI chimera

<400>  11
gtgaaggacg aaaagtctaa gactctgttt gaggttgaag gagctgttac agcgttactg       60

cccgctgccg aattccgtgt caaactggac aatgagcacg agatcatctg ccatgtctcc      120

ggtaaagtta gacgctctaa gatacgcatc atcatcggcg acagggtact cgtggaaatg      180

tccatctatg atcgcaacgc taagaaaggc aggatcattc gtcgactgaa aggaactagt      240

gaccgcacta tctcaaag                                                    258


<210>  12
<211>  3174
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SSFI Chimera with 5' Murine IgK chain leader and 3' C-myc tag

<400>  12
atggaaaccg acacgttgct tttatgggtg ttactcttat gggtgcccgg aagtacgggt       60

gacacggatc atgcacagtt caacttcacg gtgagcctcc tccagaaagt cgcacagaag      120

gacaagagta tcatactgtc cccactttct gttagtactt cgctgttcat gatctaccta      180

gcagctgacg gcaagactaa gcagcaactg gaggacgtat taggtggtac tgcatctacc      240

gaggaggtcc gcttgcactt cgccaaactg ctcgccacca atgagaacgt tgaaaacgag      300

aactacacac tcaggctcgc taatcgattt tatgtcagac aggagttccg taccaaggag      360

tcctttacta gaaccttgca atactactac aacgagaaac tctacaactt caattatggc      420

gagaaataca agttcgtcca ggaaatcaac aagtggatta gcggtaaaac taataacaag      480

attacggaat tgataaccgc ggattccgtt tcagacgaca tcaagatgct cctgctaaac      540

gctatccact tttccggtac ttgggagact caatttatga aagatgtcac caagcagaaa      600

gatttctaca tctcggaaca caagaccaag aaggtgccta tgatgatgac gacctacgcc      660

ataccatatt tcgaggacga ctttgtgcaa gtggtgaaga tgccatacgt gggaaacgag      720

atcgaaatgg ttttcatttt accgaagatc agatatggct tgtccaacgt cctgcaaaac      780

ttaacgggat ctgacctggt gcgctacatt cacaatgcga agcctaccct gtcgagcttg      840

aagataccta ggttcgagct gaagggcaag ctgaatctca agaaaacctt ggctaatata      900

ggcattactg acgccttctc tcgtgctgcc aacttcaaag agcttacaaa cgacgaaatt      960

tcagtgggct cgatcattca tgcaggattc atcgctgtgg atgagaaggg taccgagtca     1020

gccgcggcaa caaaagtcga gctcatagac aggatcagcg ccgtaaagta cttccacgcg     1080

gatcaaccat tcctattcgc tattgtccga ggactaaaga caatcttatt tgccggtcaa     1140

ttcgctggtt cgagtggtcc tctttatccc actttcgagg atctgctggt cgaccagtat     1200

cactacgaac agtacgacaa ctacagcagc catgatagcc cacccgttca ttcctatgca     1260

aaacccagtg ccccacttta cgactcaagc tcatctacca tttccgctgg ccgtatttac     1320

gaagcgatag atgagaacac cgtgagtcct gtcctgagca aaatgagcgg ttaccctgct     1380

ctcccgtcat actacgaatc aatctcacaa cctcaacatg cctctacact gaaattgtcg     1440

gagcaactcc cagaagtcag attacccaat ttgcatttgc cacagtctat tgcggtacag     1500

ccgtatatgt caaaccgtct tgtcagcttg gaaaacgatt ggatcatcgc tccgataaca     1560

ctccagtgtc ccggcctggc caagacaaat ctcacccacg gtgttcgtaa ggttatcctc     1620

aatagaacca aagacaagaa gtatggactg cgtatgaggg cggtaaacca aggcgtattc     1680

gtacagctgg tcgcagaagg ttctcccgca gctgcggcgg gcatccgttt cggtgaccag     1740

cttctgaact tgaatggtac tgaagtacta ggcatgactg gacagaaagc aatggacatt     1800

atgaagaaga gcaagcgcga ggtgattctt atcctgaggg atcgtcctct agcccgcact     1860

attggttcgt caggcaatca caccgaagag gtgacaaaat acattgctgt gacggataag     1920

ttcagcaaca tcacttactc caactttcac ctggagaaga aagagctttt gtatctgaaa     1980

caattttacc atttgttctg gctacccggt ataaatccct ctaaatacat tttcggcaca     2040

tacgacaact ccaagaactt gctggcaata ggaaacataa tcatctatcg catggtgaat     2100

tcctccaatg aggactacgt gcgattcgta tacgacgaag atcaccgcgc tgcttacgga     2160

ctccacgccg ttaagaagca catctttgag agagaaacct gggtacctgt gaacaaggaa     2220

gagttcctaa ggaagtggtc atctggaagg ttcctggatt gcattcgcct aaatatcagt     2280

acgagctgga ccaaaagcgt catcccgcac tcctacgtaa acaatatggc tacattcaga     2340

gacttcatcg aatccttcaa ggctatcccc tttcttttcg gtggtactct gctcggatgg     2400

tatcgtgagt gttcgtttat caaggacacc acagacgtcg acatggcgat gaaaattacc     2460

tccctggacc tccgcatgtt gaagaacatg gagaagagta acgacttccg cctcttttgg     2520

atcttgggca agattaacga tagtttggaa gtgtcggttt acagtgccaa cattaagatc     2580

gatcttttct tcttgtacga aaacaaagac ttcgcctggg ttggcggaat gattgtgtct     2640

aaacgcaaga aattcagatg ggtctatcca ccaatctctc agatttgcac aggagatctg     2700

ttaggtcgcc ttttccacgt cccgtgcaac gtagaggaag tgttgaaggc cgattacggt     2760

gattggcgta tcccttatcc tacagccaac ttcacgtggt acaaaacgca caagaacatc     2820

catgaggctg gatactggtc agaaaacgaa tggaacgata catacaagat ctttggttcc     2880

tcaggtgtga aggacgaaaa gtctaagact ctgtttgagg ttgaaggagc tgttacagcg     2940

ttactgcccg ctgccgaatt ccgtgtcaaa ctggacaatg agcacgagat catctgccat     3000

gtctccggta aagttagacg ctctaagata cgcatcatca tcggcgacag ggtactcgtg     3060

gaaatgtcca tctatgatcg caacgctaag aaaggcagga tcattcgtcg actgaaagga     3120

actagtgacc gcactatctc aaaggaacag aagctcatct cggaggaaga tctc           3174


<210>  13
<211>  471
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M1 segment of M1-UDP-Exp2-IF1-GST (MUEIG) chimera

<400>  13

Glu Asn Trp Gly Leu Val Ile Phe Gln Lys Glu Met Phe Leu Leu Asp 
1               5                   10                  15      


Ser Leu Leu Glu Ser Asn Ala Asn Met Thr Val Asp Leu Leu Ala Glu 
            20                  25                  30          


Gln Tyr Asp Ile Glu Lys Ile Ile Thr His Glu Leu Val His Gln Trp 
        35                  40                  45              


Phe Gly Asn Leu Val Thr Ile Asn Asp Trp Ser Glu Leu Trp Ile Ser 
    50                  55                  60                  


Glu Gly Phe Ala Ser Tyr Tyr Ala Asn Asp Phe Leu Lys Lys Gln Arg 
65                  70                  75                  80  


Pro Ile Leu Ala Ile Asn Glu Tyr Phe Leu Arg Leu Ser Gln Leu Leu 
                85                  90                  95      


Ser Arg Gln Thr Ser Asn Glu Lys Met Pro Leu Val Lys Arg Phe Arg 
            100                 105                 110         


Thr Glu Ala Glu Val Glu Lys Ala Phe Asn Pro Tyr His Leu Tyr Thr 
        115                 120                 125             


Lys Gly Ala Ala Ile Val Lys Met Met Cys Asp Leu Val Gly Glu Asn 
    130                 135                 140                 


Asn Phe Arg Glu Gly Val Arg Arg Phe Leu Lys Thr Asn Ala Tyr Lys 
145                 150                 155                 160 


Ser Val Gly Arg Ser Ala Leu Trp Lys Ala Met Pro Ile Tyr Thr Lys 
                165                 170                 175     


His Gly Leu Glu Asn Arg Lys Leu Glu Asn Val Ile Glu Pro Trp Leu 
            180                 185                 190         


Ile Asn Asp Gly Met Pro Glu Val Met Val Ser Arg Asn Tyr Asn Tyr 
        195                 200                 205             


Gly Thr Ile His Leu Ile Pro Arg Leu Ser Asp Gln Asn Arg Tyr Ile 
    210                 215                 220                 


Ile Tyr Leu Arg Asp Val Ser Tyr Asp Val Lys Asn Ser Asn Glu Ser 
225                 230                 235                 240 


Ile Lys Lys Met Lys Arg Lys Lys Trp Met Asp Lys Ile Pro Ile Arg 
                245                 250                 255     


Ser Arg Met Lys Phe Arg Lys Thr Gly Arg Ser Lys Lys Thr Glu Val 
            260                 265                 270         


Ala Asn Asp Glu Glu Val Ser Ser Phe Phe Tyr Phe Asp Phe Ile Asn 
        275                 280                 285             


Asn Met Leu Pro Asn Ser Arg Lys Glu Val Lys Leu Lys Gln Thr Ile 
    290                 295                 300                 


Gly Gly Gly Asn Pro Val Gly Arg Arg Lys Lys Glu Arg Arg His Arg 
305                 310                 315                 320 


Lys Ile Asn Glu Lys Trp Arg Ser Ser Gln Glu Gln Gln Phe Trp Ser 
                325                 330                 335     


Ile Pro Phe Thr Tyr Gln Leu Ser Ser Lys Thr Asn Phe Phe Gly Asp 
            340                 345                 350         


Thr Ile Arg Glu Leu Trp Leu His Asn Lys Thr Val Val Phe Met Asp 
        355                 360                 365             


Lys Lys Ala Gln Ala Ser Ala Thr Leu Leu Ala Asn Val Asn Trp Lys 
    370                 375                 380                 


Tyr Pro Tyr Arg Val Asn Tyr Asp Ile Glu Asn Trp Lys Met Leu Ala 
385                 390                 395                 400 


Arg Leu Leu His Glu Asn His Leu Ser Ile Pro Leu Tyr Ser Arg Ile 
                405                 410                 415     


Gln Leu Ile Phe Asp Ser Glu Phe Tyr Leu Lys Gln Ser Asn Val Pro 
            420                 425                 430         


Glu Val Tyr Leu Tyr Ile Leu Ser Tyr Leu Thr Lys Glu Asn Asp Val 
        435                 440                 445             


Gly Leu Leu Leu Phe Gly Leu Asp Ala Leu Tyr Arg Phe Phe Asp Met 
    450                 455                 460                 


Phe Arg Gly Ser Ser Ile Asn 
465                 470     


<210>  14
<211>  248
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  UDP segment of MUEIG chimera

<400>  14

Leu Leu His Ala Ala Leu Leu Ser Met Leu Leu Glu Ser Ile Phe Ser 
1               5                   10                  15      


Tyr Lys Ile Leu Ile Phe Ser Pro Arg Leu Ala His Ser His Ile Asn 
            20                  25                  30          


Phe Met Gly Ile Leu Ala Asp Val Leu Val Glu Ala Gly His Asp Ile 
        35                  40                  45              


Thr Ile Phe Met Pro Asp Leu Asn Pro Asp Val Ser Asn Asn Gly Ser 
    50                  55                  60                  


Lys Leu Ala Lys Ile Val Arg Lys Thr Phe Ser Asn Thr Asn Asn Gln 
65                  70                  75                  80  


Ile Leu Lys Lys Asn Ser Ala Arg Glu Lys Trp Lys Lys Lys Gly Asp 
                85                  90                  95      


Ser Ile Leu Gln Val Tyr Arg Leu Phe Gln Gln Leu Ala Asp Ser Gln 
            100                 105                 110         


Arg Leu Met Cys Leu Glu His Leu Glu Asp Asp Lys Leu Ile Ser Trp 
        115                 120                 125             


Leu Gln Thr Glu Gln Tyr Asp Leu Gly Ile Thr Glu Gln Ile Ser Phe 
    130                 135                 140                 


Cys Gly Tyr Ala Ile Phe Asn Arg Ile Gly Leu Asn Asn Gln Val Thr 
145                 150                 155                 160 


Ala Gly Ala Ile Thr Leu Met Glu Val Leu Ser Asp Pro Phe Gly Val 
                165                 170                 175     


Ser Ser Asn Pro Ser Tyr Val Pro Gly Gly Phe Ser Ser Lys Ala Asp 
            180                 185                 190         


Lys Met Asn Tyr Leu Glu Arg Leu Ala Asn Ile Ile Ile Tyr Thr Thr 
        195                 200                 205             


Ser Tyr Ile Leu Thr Lys Phe Val Trp Glu Pro Ala Val Gln Ser Leu 
    210                 215                 220                 


Gln His Asn Leu Pro Asn Asn Phe Asn Tyr Ile Glu Thr Leu Lys Asn 
225                 230                 235                 240 


Ser Ser Leu Tyr Phe Val Asn Thr 
                245             


<210>  15
<211>  78
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exp2 segment of MUEIG chimera

<400>  15

Gly Leu Ser Phe Gly Thr Ile Pro Asp Phe Gln Val Val Gln Tyr Leu 
1               5                   10                  15      


Pro Thr Tyr Asn Glu Thr Val Leu Leu Pro Asn Gly Thr Ile Thr Val 
            20                  25                  30          


Val Glu Lys Ile Glu Glu Met Arg Ile Glu His Pro Ile Phe Val Leu 
        35                  40                  45              


Thr Glu Arg Ile Cys Ile Ala Phe Phe Thr Ile Glu Tyr Cys Leu Arg 
    50                  55                  60                  


Leu Phe Ala Ala Pro Arg Lys Leu Arg Phe Met Leu Lys Pro 
65                  70                  75              


<210>  16
<211>  86
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IF1 segment of MUEIG chimera

<400>  16

Val Lys Asp Glu Lys Ser Lys Thr Leu Phe Glu Val Glu Gly Ala Val 
1               5                   10                  15      


Thr Ala Leu Leu Pro Ala Ala Glu Phe Arg Val Lys Leu Asp Asn Glu 
            20                  25                  30          


His Glu Ile Ile Cys His Val Ser Gly Lys Val Arg Arg Ser Lys Ile 
        35                  40                  45              


Arg Ile Ile Ile Gly Asp Arg Val Leu Val Glu Met Ser Ile Tyr Asp 
    50                  55                  60                  


Arg Asn Ala Lys Lys Gly Arg Ile Ile Arg Arg Leu Lys Gly Thr Ser 
65                  70                  75                  80  


Asp Arg Thr Ile Ser Lys 
                85      


<210>  17
<211>  207
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GST segment of MUEIG chimera

<400>  17

Ser Tyr Lys Leu Thr Tyr Phe Pro Ile Arg Gly Leu Ala Glu Pro Ile 
1               5                   10                  15      


Arg Leu Leu Leu Val Asp Gln Gly Ile Lys Phe Thr Asp Glu His Ile 
            20                  25                  30          


Pro Lys Asp Asp Phe Val Ser Ile Lys Ser Gln Phe Gln Phe Gly Gln 
        35                  40                  45              


Leu Pro Cys Phe Tyr Asp Gly Asp Gln Gln Ile Val Gln Ser Gly Ala 
    50                  55                  60                  


Ile Leu Arg His Leu Ala Arg Lys Phe Asn Leu Asn Gly Glu Asn Asn 
65                  70                  75                  80  


Ala Glu Thr Ser Tyr Val Asp Met Phe Tyr Glu Gly Ile Arg Asp Leu 
                85                  90                  95      


His Ser Lys Tyr Thr Arg Met Ile Tyr Glu Ala Tyr Glu Thr Gln Lys 
            100                 105                 110         


Asp Pro Phe Ile Lys Asn Ile Leu Pro Gln Glu Leu Ala Lys Leu Glu 
        115                 120                 125             


Lys Leu Leu Ala Thr Arg Asp Asn Gly Lys Asn Phe Ile Leu Gly Asp 
    130                 135                 140                 


Lys Ile Ser Phe Ala Asp Tyr Val Leu Phe Glu Glu Leu Asp Val Gln 
145                 150                 155                 160 


Gln Ile Leu Asp Pro His Cys Leu Glu Lys Phe Pro Leu Leu Lys Ala 
                165                 170                 175     


Phe His Gln Arg Leu Gly Asp Lys Pro Lys Ile Lys Glu Tyr Cys Ala 
            180                 185                 190         


Lys Arg Asn Ala Ser Lys Met Pro Val Asn Gly Asn Gly Lys Gln 
        195                 200                 205         


<210>  18
<211>  1137
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MUEIG Chimera with 5' Murine IgK chain leader and 3' C-myc tag

<400>  18

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Glu Asn Trp Gly Leu Val Ile Phe Gln Lys Glu 
            20                  25                  30          


Met Phe Leu Leu Asp Ser Leu Leu Glu Ser Asn Ala Asn Met Thr Val 
        35                  40                  45              


Asp Leu Leu Ala Glu Gln Tyr Asp Ile Glu Lys Ile Ile Thr His Glu 
    50                  55                  60                  


Leu Val His Gln Trp Phe Gly Asn Leu Val Thr Ile Asn Asp Trp Ser 
65                  70                  75                  80  


Glu Leu Trp Ile Ser Glu Gly Phe Ala Ser Tyr Tyr Ala Asn Asp Phe 
                85                  90                  95      


Leu Lys Lys Gln Arg Pro Ile Leu Ala Ile Asn Glu Tyr Phe Leu Arg 
            100                 105                 110         


Leu Ser Gln Leu Leu Ser Arg Gln Thr Ser Asn Glu Lys Met Pro Leu 
        115                 120                 125             


Val Lys Arg Phe Arg Thr Glu Ala Glu Val Glu Lys Ala Phe Asn Pro 
    130                 135                 140                 


Tyr His Leu Tyr Thr Lys Gly Ala Ala Ile Val Lys Met Met Cys Asp 
145                 150                 155                 160 


Leu Val Gly Glu Asn Asn Phe Arg Glu Gly Val Arg Arg Phe Leu Lys 
                165                 170                 175     


Thr Asn Ala Tyr Lys Ser Val Gly Arg Ser Ala Leu Trp Lys Ala Met 
            180                 185                 190         


Pro Ile Tyr Thr Lys His Gly Leu Glu Asn Arg Lys Leu Glu Asn Val 
        195                 200                 205             


Ile Glu Pro Trp Leu Ile Asn Asp Gly Met Pro Glu Val Met Val Ser 
    210                 215                 220                 


Arg Asn Tyr Asn Tyr Gly Thr Ile His Leu Ile Pro Arg Leu Ser Asp 
225                 230                 235                 240 


Gln Asn Arg Tyr Ile Ile Tyr Leu Arg Asp Val Ser Tyr Asp Val Lys 
                245                 250                 255     


Asn Ser Asn Glu Ser Ile Lys Lys Met Lys Arg Lys Lys Trp Met Asp 
            260                 265                 270         


Lys Ile Pro Ile Arg Ser Arg Met Lys Phe Arg Lys Thr Gly Arg Ser 
        275                 280                 285             


Lys Lys Thr Glu Val Ala Asn Asp Glu Glu Val Ser Ser Phe Phe Tyr 
    290                 295                 300                 


Phe Asp Phe Ile Asn Asn Met Leu Pro Asn Ser Arg Lys Glu Val Lys 
305                 310                 315                 320 


Leu Lys Gln Thr Ile Gly Gly Gly Asn Pro Val Gly Arg Arg Lys Lys 
                325                 330                 335     


Glu Arg Arg His Arg Lys Ile Asn Glu Lys Trp Arg Ser Ser Gln Glu 
            340                 345                 350         


Gln Gln Phe Trp Ser Ile Pro Phe Thr Tyr Gln Leu Ser Ser Lys Thr 
        355                 360                 365             


Asn Phe Phe Gly Asp Thr Ile Arg Glu Leu Trp Leu His Asn Lys Thr 
    370                 375                 380                 


Val Val Phe Met Asp Lys Lys Ala Gln Ala Ser Ala Thr Leu Leu Ala 
385                 390                 395                 400 


Asn Val Asn Trp Lys Tyr Pro Tyr Arg Val Asn Tyr Asp Ile Glu Asn 
                405                 410                 415     


Trp Lys Met Leu Ala Arg Leu Leu His Glu Asn His Leu Ser Ile Pro 
            420                 425                 430         


Leu Tyr Ser Arg Ile Gln Leu Ile Phe Asp Ser Glu Phe Tyr Leu Lys 
        435                 440                 445             


Gln Ser Asn Val Pro Glu Val Tyr Leu Tyr Ile Leu Ser Tyr Leu Thr 
    450                 455                 460                 


Lys Glu Asn Asp Val Gly Leu Leu Leu Phe Gly Leu Asp Ala Leu Tyr 
465                 470                 475                 480 


Arg Phe Phe Asp Met Phe Arg Gly Ser Ser Ile Asn Gly Ser Ser Gly 
                485                 490                 495     


Leu Leu His Ala Ala Leu Leu Ser Met Leu Leu Glu Ser Ile Phe Ser 
            500                 505                 510         


Tyr Lys Ile Leu Ile Phe Ser Pro Arg Leu Ala His Ser His Ile Asn 
        515                 520                 525             


Phe Met Gly Ile Leu Ala Asp Val Leu Val Glu Ala Gly His Asp Ile 
    530                 535                 540                 


Thr Ile Phe Met Pro Asp Leu Asn Pro Asp Val Ser Asn Asn Gly Ser 
545                 550                 555                 560 


Lys Leu Ala Lys Ile Val Arg Lys Thr Phe Ser Asn Thr Asn Asn Gln 
                565                 570                 575     


Ile Leu Lys Lys Asn Ser Ala Arg Glu Lys Trp Lys Lys Lys Gly Asp 
            580                 585                 590         


Ser Ile Leu Gln Val Tyr Arg Leu Phe Gln Gln Leu Ala Asp Ser Gln 
        595                 600                 605             


Arg Leu Met Cys Leu Glu His Leu Glu Asp Asp Lys Leu Ile Ser Trp 
    610                 615                 620                 


Leu Gln Thr Glu Gln Tyr Asp Leu Gly Ile Thr Glu Gln Ile Ser Phe 
625                 630                 635                 640 


Cys Gly Tyr Ala Ile Phe Asn Arg Ile Gly Leu Asn Asn Gln Val Thr 
                645                 650                 655     


Ala Gly Ala Ile Thr Leu Met Glu Val Leu Ser Asp Pro Phe Gly Val 
            660                 665                 670         


Ser Ser Asn Pro Ser Tyr Val Pro Gly Gly Phe Ser Ser Lys Ala Asp 
        675                 680                 685             


Lys Met Asn Tyr Leu Glu Arg Leu Ala Asn Ile Ile Ile Tyr Thr Thr 
    690                 695                 700                 


Ser Tyr Ile Leu Thr Lys Phe Val Trp Glu Pro Ala Val Gln Ser Leu 
705                 710                 715                 720 


Gln His Asn Leu Pro Asn Asn Phe Asn Tyr Ile Glu Thr Leu Lys Asn 
                725                 730                 735     


Ser Ser Leu Tyr Phe Val Asn Thr Gly Ser Ser Gly Gly Leu Ser Phe 
            740                 745                 750         


Gly Thr Ile Pro Asp Phe Gln Val Val Gln Tyr Leu Pro Thr Tyr Asn 
        755                 760                 765             


Glu Thr Val Leu Leu Pro Asn Gly Thr Ile Thr Val Val Glu Lys Ile 
    770                 775                 780                 


Glu Glu Met Arg Ile Glu His Pro Ile Phe Val Leu Thr Glu Arg Ile 
785                 790                 795                 800 


Cys Ile Ala Phe Phe Thr Ile Glu Tyr Cys Leu Arg Leu Phe Ala Ala 
                805                 810                 815     


Pro Arg Lys Leu Arg Phe Met Leu Lys Pro Gly Ser Ser Gly Val Lys 
            820                 825                 830         


Asp Glu Lys Ser Lys Thr Leu Phe Glu Val Glu Gly Ala Val Thr Ala 
        835                 840                 845             


Leu Leu Pro Ala Ala Glu Phe Arg Val Lys Leu Asp Asn Glu His Glu 
    850                 855                 860                 


Ile Ile Cys His Val Ser Gly Lys Val Arg Arg Ser Lys Ile Arg Ile 
865                 870                 875                 880 


Ile Ile Gly Asp Arg Val Leu Val Glu Met Ser Ile Tyr Asp Arg Asn 
                885                 890                 895     


Ala Lys Lys Gly Arg Ile Ile Arg Arg Leu Lys Gly Thr Ser Asp Arg 
            900                 905                 910         


Thr Ile Ser Lys Gly Ser Ser Gly Ser Tyr Lys Leu Thr Tyr Phe Pro 
        915                 920                 925             


Ile Arg Gly Leu Ala Glu Pro Ile Arg Leu Leu Leu Val Asp Gln Gly 
    930                 935                 940                 


Ile Lys Phe Thr Asp Glu His Ile Pro Lys Asp Asp Phe Val Ser Ile 
945                 950                 955                 960 


Lys Ser Gln Phe Gln Phe Gly Gln Leu Pro Cys Phe Tyr Asp Gly Asp 
                965                 970                 975     


Gln Gln Ile Val Gln Ser Gly Ala Ile Leu Arg His Leu Ala Arg Lys 
            980                 985                 990         


Phe Asn Leu Asn Gly Glu Asn Asn  Ala Glu Thr Ser Tyr  Val Asp Met 
        995                 1000                 1005             


Phe Tyr  Glu Gly Ile Arg Asp  Leu His Ser Lys Tyr  Thr Arg Met 
    1010                 1015                 1020             


Ile Tyr  Glu Ala Tyr Glu Thr  Gln Lys Asp Pro Phe  Ile Lys Asn 
    1025                 1030                 1035             


Ile Leu  Pro Gln Glu Leu Ala  Lys Leu Glu Lys Leu  Leu Ala Thr 
    1040                 1045                 1050             


Arg Asp  Asn Gly Lys Asn Phe  Ile Leu Gly Asp Lys  Ile Ser Phe 
    1055                 1060                 1065             


Ala Asp  Tyr Val Leu Phe Glu  Glu Leu Asp Val Gln  Gln Ile Leu 
    1070                 1075                 1080             


Asp Pro  His Cys Leu Glu Lys  Phe Pro Leu Leu Lys  Ala Phe His 
    1085                 1090                 1095             


Gln Arg  Leu Gly Asp Lys Pro  Lys Ile Lys Glu Tyr  Cys Ala Lys 
    1100                 1105                 1110             


Arg Asn  Ala Ser Lys Met Pro  Val Asn Gly Asn Gly  Lys Gln Glu 
    1115                 1120                 1125             


Gln Lys  Leu Ile Ser Glu Glu  Asp Leu 
    1130                 1135         


<210>  19
<211>  1413
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  M1 segment of MUEIG chimera

<400>  19
gagaactggg gcttggtgat tttccaaaag gagatgttcc tcctcgattc tctcctcgaa       60

agcaacgcca acatgaccgt ggatttgctt gcggagcaat acgacattga gaaaatcatc      120

acacacgaat tagtgcacca gtggttcgga aaccttgtta cgatcaatga ttggagcgaa      180

ctctggattt cagagggatt cgcgagttac tacgctaatg atttcctgaa gaagcagcgt      240

cccatcttag cgatcaacga gtatttcctt aggttgtctc aactgttgtc acgtcagaca      300

tccaacgaga agatgccgct cgtaaagcgc tttcgcactg aggcagaagt tgagaaggcc      360

tttaacccat accacctgta tacgaaaggc gcggccatag tcaagatgat gtgcgacctt      420

gtcggcgaaa acaactttcg tgagggagtc cgtcgtttcc ttaaaacaaa cgcctataag      480

tcggtaggta ggtctgctct ttggaaggcg atgccaatct acacaaagca cggtctggaa      540

aatcgaaagc tggaaaacgt gatcgagccc tggttgatta acgacggtat gcctgaggtt      600

atggtatccc gaaactacaa ttacggaact atccatttga tacccagact gtctgaccag      660

aataggtaca tcatctattt gcgcgatgtg agctatgacg tcaagaactc taacgaatcc      720

attaagaaga tgaagcgtaa gaaatggatg gacaaaatcc ccatccgcag caggatgaag      780

ttcagaaaga caggtcgcag caagaagacg gaggtagcta atgacgagga agtctctagt      840

ttcttttact tcgatttcat taacaacatg ctgcctaatt ctcgaaaaga ggttaagctc      900

aaacaaacga taggaggcgg caatccagtg ggtagacgta agaaagaaag aaggcatcgc      960

aagatcaacg agaagtggcg cagctcccaa gaacaacagt tctggtccat tcctttcacc     1020

tatcaattat caagtaaaac aaacttcttt ggtgacacga taagagagct gtggctccac     1080

aacaagaccg tcgtgttcat ggacaagaaa gctcaggcct ctgctacact cctggcgaac     1140

gttaactgga aatacccgta ccgagttaac tacgatattg agaactggaa gatgctcgct     1200

cgcctcctgc acgagaacca cttgtcaatc cctttgtata gtcgcatcca gctaatcttc     1260

gactcagaat tttacttgaa gcaaagcaac gtgcctgagg tctacttgta tatcctctcc     1320

tacctcacca aggagaatga cgtcggcctt cttcttttcg gtttggatgc actgtaccgc     1380

ttctttgaca tgttccgcgg ctcatcaatc aat                                  1413


<210>  20
<211>  744
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  UDP segment of MUEIG chimera

<400>  20
ctactgcatg ctgctctgct aagtatgcta ctcgaatcca tcttctcgta caagatcttg       60

atcttctcgc cacgtctagc acattcgcac atcaatttca tgggaattct cgctgatgta      120

cttgtggagg caggccatga tatcaccatc ttcatgccgg acttaaatcc cgacgtaagt      180

aataacggtt caaagttagc aaagatcgtg cgcaaaacct tctcgaacac caacaaccag      240

atcctgaaaa aaaactccgc ccgtgaaaag tggaagaaga aaggtgattc aatcttacag      300

gtctacagac tgtttcagca actcgcagac tctcagagat taatgtgtct ggaacacttg      360

gaggatgaca agctgatttc gtggcttcag acagagcaat acgatctcgg catcactgag      420

caaatatcgt tttgtggcta tgccatcttt aacaggatcg gcttgaataa ccaggtaacc      480

gccggagcta taaccctgat ggaggtgctg tctgatccat tcggcgtgtc aagcaatcca      540

agctacgtac ccggaggttt ctccagcaaa gccgacaaaa tgaattacct ggagagactc      600

gccaatatta tcatctatac aacctcctac attttaacca agttcgtctg ggagccagct      660

gttcagagtc tgcagcacaa tctacccaac aacttcaact acattgaaac tctgaagaat      720

tcctccctgt actttgtcaa cact                                             744


<210>  21
<211>  234
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exp2 segment of MUEIG chimera

<400>  21
ggtttatctt tcggaaccat tcccgatttc caagtggtgc agtacctacc cacatacaat       60

gaaactgtgc tcctcccgaa cggaactata actgtggtcg agaaaattga agaaatgcga      120

atcgaacacc caattttcgt tctgaccgag cgtatatgca ttgcgttctt tacgatagaa      180

tattgtctgc gcctgttcgc agcgcctaga aaattgcgtt tcatgcttaa accc            234


<210>  22
<211>  258
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IF1 segment of MUEIG chimera

<400>  22
gtcaaagacg aaaagtctaa gacgctattt gaagtagagg gtgcggtcac agcattgctg       60

cctgcagccg aattccgcgt taagctggac aacgaacacg aaatcatctg ccacgttagt      120

ggaaaggtgc gccgcagcaa gattcgcatt atcattggag acagagtgct ggtcgaaatg      180

tcaatctacg acagaaacgc taagaaaggt aggattattc gccgtctgaa aggaacttcc      240

gacaggacta tttccaag                                                    258


<210>  23
<211>  621
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GST segment of MUEIG chimera

<400>  23
agctacaagc taacctactt cccgataagg ggtttggctg agccgattag gttgctttta       60

gttgaccaag gcatcaaatt cacggacgaa catataccta aagatgactt cgtcagcatt      120

aagagtcagt tccaatttgg ccaattgcct tgcttctacg atggtgacca acagatcgtg      180

cagtcaggtg caatcctgag acacttggct cgtaagttca acttgaatgg cgagaacaac      240

gccgaaactt cctacgtaga tatgttttat gagggcataa gggacctaca ctccaagtat      300

actcgcatga tctatgaggc ctacgaaacc cagaaagatc cattcatcaa gaatatactc      360

ccacaggagc tcgctaagct agaaaagctg ctcgctaccc gtgacaacgg taagaacttc      420

atactgggtg acaaaatctc gttcgccgat tacgtgctgt ttgaggagtt ggacgtacag      480

caaatcttag accctcattg cctggagaaa ttccctctcc ttaaggcctt tcatcagagg      540

ctgggtgata aacccaagat caaagaatac tgtgctaagc gtaacgcttc aaagatgcct      600

gtcaacggta acggcaagca a                                                621


<210>  24
<211>  3411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MUEIG Chimera with 5' Murine IgK chain leader and 3' C-myc tag

<400>  24
atggaaacag acacgttatt gctgtgggtg ctcctccttt gggttccagg atcgactggt       60

gacgagaact ggggcttggt gattttccaa aaggagatgt tcctcctcga ttctctcctc      120

gaaagcaacg ccaacatgac cgtggatttg cttgcggagc aatacgacat tgagaaaatc      180

atcacacacg aattagtgca ccagtggttc ggaaaccttg ttacgatcaa tgattggagc      240

gaactctgga tttcagaggg attcgcgagt tactacgcta atgatttcct gaagaagcag      300

cgtcccatct tagcgatcaa cgagtatttc cttaggttgt ctcaactgtt gtcacgtcag      360

acatccaacg agaagatgcc gctcgtaaag cgctttcgca ctgaggcaga agttgagaag      420

gcctttaacc cataccacct gtatacgaaa ggcgcggcca tagtcaagat gatgtgcgac      480

cttgtcggcg aaaacaactt tcgtgaggga gtccgtcgtt tccttaaaac aaacgcctat      540

aagtcggtag gtaggtctgc tctttggaag gcgatgccaa tctacacaaa gcacggtctg      600

gaaaatcgaa agctggaaaa cgtgatcgag ccctggttga ttaacgacgg tatgcctgag      660

gttatggtat cccgaaacta caattacgga actatccatt tgatacccag actgtctgac      720

cagaataggt acatcatcta tttgcgcgat gtgagctatg acgtcaagaa ctctaacgaa      780

tccattaaga agatgaagcg taagaaatgg atggacaaaa tccccatccg cagcaggatg      840

aagttcagaa agacaggtcg cagcaagaag acggaggtag ctaatgacga ggaagtctct      900

agtttctttt acttcgattt cattaacaac atgctgccta attctcgaaa agaggttaag      960

ctcaaacaaa cgataggagg cggcaatcca gtgggtagac gtaagaaaga aagaaggcat     1020

cgcaagatca acgagaagtg gcgcagctcc caagaacaac agttctggtc cattcctttc     1080

acctatcaat tatcaagtaa aacaaacttc tttggtgaca cgataagaga gctgtggctc     1140

cacaacaaga ccgtcgtgtt catggacaag aaagctcagg cctctgctac actcctggcg     1200

aacgttaact ggaaataccc gtaccgagtt aactacgata ttgagaactg gaagatgctc     1260

gctcgcctcc tgcacgagaa ccacttgtca atccctttgt atagtcgcat ccagctaatc     1320

ttcgactcag aattttactt gaagcaaagc aacgtgcctg aggtctactt gtatatcctc     1380

tcctacctca ccaaggagaa tgacgtcggc cttcttcttt tcggtttgga tgcactgtac     1440

cgcttctttg acatgttccg cggctcatca atcaatggtt ccagtggact actgcatgct     1500

gctctgctaa gtatgctact cgaatccatc ttctcgtaca agatcttgat cttctcgcca     1560

cgtctagcac attcgcacat caatttcatg ggaattctcg ctgatgtact tgtggaggca     1620

ggccatgata tcaccatctt catgccggac ttaaatcccg acgtaagtaa taacggttca     1680

aagttagcaa agatcgtgcg caaaaccttc tcgaacacca acaaccagat cctgaaaaaa     1740

aactccgccc gtgaaaagtg gaagaagaaa ggtgattcaa tcttacaggt ctacagactg     1800

tttcagcaac tcgcagactc tcagagatta atgtgtctgg aacacttgga ggatgacaag     1860

ctgatttcgt ggcttcagac agagcaatac gatctcggca tcactgagca aatatcgttt     1920

tgtggctatg ccatctttaa caggatcggc ttgaataacc aggtaaccgc cggagctata     1980

accctgatgg aggtgctgtc tgatccattc ggcgtgtcaa gcaatccaag ctacgtaccc     2040

ggaggtttct ccagcaaagc cgacaaaatg aattacctgg agagactcgc caatattatc     2100

atctatacaa cctcctacat tttaaccaag ttcgtctggg agccagctgt tcagagtctg     2160

cagcacaatc tacccaacaa cttcaactac attgaaactc tgaagaattc ctccctgtac     2220

tttgtcaaca ctggttcttc tggaggttta tctttcggaa ccattcccga tttccaagtg     2280

gtgcagtacc tacccacata caatgaaact gtgctcctcc cgaacggaac tataactgtg     2340

gtcgagaaaa ttgaagaaat gcgaatcgaa cacccaattt tcgttctgac cgagcgtata     2400

tgcattgcgt tctttacgat agaatattgt ctgcgcctgt tcgcagcgcc tagaaaattg     2460

cgtttcatgc ttaaacccgg aagcagtggc gtcaaagacg aaaagtctaa gacgctattt     2520

gaagtagagg gtgcggtcac agcattgctg cctgcagccg aattccgcgt taagctggac     2580

aacgaacacg aaatcatctg ccacgttagt ggaaaggtgc gccgcagcaa gattcgcatt     2640

atcattggag acagagtgct ggtcgaaatg tcaatctacg acagaaacgc taagaaaggt     2700

aggattattc gccgtctgaa aggaacttcc gacaggacta tttccaaggg ttcaagcggt     2760

agctacaagc taacctactt cccgataagg ggtttggctg agccgattag gttgctttta     2820

gttgaccaag gcatcaaatt cacggacgaa catataccta aagatgactt cgtcagcatt     2880

aagagtcagt tccaatttgg ccaattgcct tgcttctacg atggtgacca acagatcgtg     2940

cagtcaggtg caatcctgag acacttggct cgtaagttca acttgaatgg cgagaacaac     3000

gccgaaactt cctacgtaga tatgttttat gagggcataa gggacctaca ctccaagtat     3060

actcgcatga tctatgaggc ctacgaaacc cagaaagatc cattcatcaa gaatatactc     3120

ccacaggagc tcgctaagct agaaaagctg ctcgctaccc gtgacaacgg taagaacttc     3180

atactgggtg acaaaatctc gttcgccgat tacgtgctgt ttgaggagtt ggacgtacag     3240

caaatcttag accctcattg cctggagaaa ttccctctcc ttaaggcctt tcatcagagg     3300

ctgggtgata aacccaagat caaagaatac tgtgctaagc gtaacgcttc aaagatgcct     3360

gtcaacggta acggcaagca agagcagaaa ttgatctcgg aggaagatct c              3411


<210>  25
<211>  369
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Necepsin segment of Necepsin-Prof2-TPP-ShTK (NPTS) chimera

<400>  25

Ser Lys Ile Gly Ser Val Arg Gln Gln Leu Leu Arg Ala Gly Lys Leu 
1               5                   10                  15      


Lys Gln Phe Asn Asn Leu Ile Gln Ser Leu Leu Lys Glu Asn Gly Ile 
            20                  25                  30          


Val Asp Phe Phe Glu Tyr Met Asp Asn Ile Tyr Val Ile Asn Val Thr 
        35                  40                  45              


Ile Gly Thr Pro Pro Gln His Phe Glu Ile Val Pro Asp Thr Gly Ser 
    50                  55                  60                  


Ser Asp Leu Trp Val Ile Ser Ile Lys Cys Asn Ser Gln Ser Cys Lys 
65                  70                  75                  80  


Gly Asp Lys Leu His Pro Lys Asn Arg Phe Asp Pro Ser Lys Ser Ser 
                85                  90                  95      


Thr Tyr Ser Val Asp Gly Arg Lys Phe Thr Ile Thr Tyr Glu Leu Gly 
            100                 105                 110         


Tyr Ala Glu Gly Ile Leu Gly Ile Asp His Phe Ser Phe Ala Asp Leu 
        115                 120                 125             


Ala Val Glu Met Gln Thr Phe Gly Leu Ala Glu Gln Ile Ala His Val 
    130                 135                 140                 


Phe Gly Asp Ile Pro Ile Asp Gly Ile Met Gly Leu Ala Trp Pro Ala 
145                 150                 155                 160 


Leu Ser Glu Phe Gln Val Thr Pro Pro Met Gln Asn Ile Leu Asp Glu 
                165                 170                 175     


Leu Asp Glu Pro Ile Met Thr Val Tyr Met Thr Arg Glu Ile Glu Pro 
            180                 185                 190         


Ile Met Glu Glu Val Tyr Gly Gly Glu Ile Thr Phe Gly Gly Phe Asp 
        195                 200                 205             


Glu Gln Asn Cys Glu Leu Pro Ile Arg Trp Val Glu Leu Thr Ser Gln 
    210                 215                 220                 


Ser Phe Trp Gln Phe Thr Val Thr Gly Val Arg Val Gln Ser Tyr Lys 
225                 230                 235                 240 


Asn Thr Asn Trp Leu Gln Gly Ile Ser Asp Thr Gly Thr Ser Tyr Leu 
                245                 250                 255     


Ile Ile Pro Thr Phe Leu Met Lys Pro Ile Ile Lys Lys Ile Asn Ala 
            260                 265                 270         


Thr Phe Ser Phe Asp Tyr Asp Ala Tyr Val Leu Asp Cys Ser Met Arg 
        275                 280                 285             


Asn Thr Gly Pro Asn Ile Glu Ile Ala Ile Ser Gly Leu Tyr Tyr Ser 
    290                 295                 300                 


Ile Pro Pro Glu Gln Tyr Ile Leu Gln Tyr Ile Asp Glu Ser Gly Ser 
305                 310                 315                 320 


Pro Val Cys Ile Phe Ala Ala Phe Glu Asn Phe Gly Val Gly Phe Ser 
                325                 330                 335     


Pro Ala Trp Ile Leu Gly Asp Val Phe Ile Arg Ser Tyr Cys Asn Val 
            340                 345                 350         


His Asp Tyr Val Asn Asn Arg Ile Gly Phe Ala Lys Ser Tyr Phe Gln 
        355                 360                 365             


Gln 
    


<210>  26
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Prof2 segment of NPTS chimera

<400>  26

Ser Gly Trp Ala Ala Tyr Ile Lys Asn Leu Leu Asp Ser Ser Gln Gly 
1               5                   10                  15      


Ile Gln Arg Ala Ala Ile Val Gly Tyr Pro Asp Gly Ser Val Trp Ala 
            20                  25                  30          


Arg Ser Glu Gly Asp Arg Glu Phe Arg Ala Thr Asp Glu Glu Leu Lys 
        35                  40                  45              


Lys Phe Val Ser Leu Tyr Asp His Ile Glu Lys Val Pro Ala Thr Gly 
    50                  55                  60                  


Cys Asp Leu Glu Gly Val His Tyr Ile Val Pro Arg Thr Glu Gln Asn 
65                  70                  75                  80  


Leu Ile Phe Gly Lys Arg Asp Lys Thr Gly Ile Phe Ala Ala Lys Thr 
                85                  90                  95      


Lys Ser Ala Val Leu Ile Ala Cys Tyr Lys Gly Glu Asn Ala Ala Glu 
            100                 105                 110         


Val Arg Val Ala Val Glu Lys Leu Ala Gln Tyr Leu Met Asp Ser Gly 
        115                 120                 125             


Tyr 
    


<210>  27
<211>  510
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP segment of NPTS chimera

<400>  27

Thr Glu Thr Ile Ala Asp Gln Glu Lys Gln Lys Asn Thr Lys Leu Glu 
1               5                   10                  15      


Lys His Glu Ala Ala Lys Asp Glu Pro Ala Glu Glu Lys Glu Arg Glu 
            20                  25                  30          


Arg Glu Thr Pro Gly Ser Gly Thr Ala Lys Asn Thr Glu Gln Asn Leu 
        35                  40                  45              


Ser Leu Ser Leu Glu Gln Thr Gly Ile Ile Lys Asn Asp Asn Val Gln 
    50                  55                  60                  


Thr Ile Asp Asp Phe Lys Asp Leu Met Tyr Lys Met Gln Glu Thr Arg 
65                  70                  75                  80  


Arg Ala Ile Val Val Ala Leu Leu Asn Glu Lys Asp Leu Lys Asn Asp 
                85                  90                  95      


Asp Ile Glu Ile Leu Arg Arg Ala Tyr Glu Lys Leu Thr Asp Asn Gln 
            100                 105                 110         


Thr His Ser Phe Gln Arg Glu Met Cys Thr Leu Thr Thr Lys Leu Ser 
        115                 120                 125             


Val Asn Ile Arg Asp Glu Thr Arg Gly Leu Glu Lys Asp Leu Lys Tyr 
    130                 135                 140                 


Leu Glu Ile Leu Thr His Ile Arg Gly Glu Glu Pro Ser Leu Ser Trp 
145                 150                 155                 160 


Pro Val Val Met Ser Arg Leu Asp Leu Ile Ser Ile Leu Ser Asn Tyr 
                165                 170                 175     


His Pro Glu Gly Lys Glu Lys Phe Met Lys Glu Tyr Glu Asn Thr Val 
            180                 185                 190         


Arg Phe Leu His Thr Phe Ile Gly Ser Glu Ala Ile Thr Gly Lys Lys 
        195                 200                 205             


Pro Ile Phe Ile Thr Asp Trp Asp Gly Thr Met Lys Asp Tyr Cys Ser 
    210                 215                 220                 


Gln Tyr Ala Thr Asn Leu Gln Pro Val Tyr Ser Ala Val Gly Met Ile 
225                 230                 235                 240 


Arg Phe Ala Asp Arg Phe Thr Arg Ile Ser Ala Val Leu Thr Ala Gly 
                245                 250                 255     


Pro Leu Arg Gly Pro Gly Ile Leu Asp Leu Thr Ala Met Pro Ile Asp 
            260                 265                 270         


Gly Pro Val Met Phe Ser Gly Ser Trp Gly Arg Glu Trp Trp Leu Ser 
        275                 280                 285             


Gly Lys Arg Val Val His Glu Asp Gly Ile Thr Asp Ala Gly Phe Asn 
    290                 295                 300                 


Ala Leu Gln Arg Leu Asp Asp Glu Met Lys Asp Leu Leu His Ser Ser 
305                 310                 315                 320 


Asp Tyr Ala Pro Phe Ala Leu Val Gly Ser Gly Val Gln Arg Lys Val 
                325                 330                 335     


Asp Arg Leu Thr Leu Gly Val Gln Thr Val Cys His His Val Thr Ser 
            340                 345                 350         


Glu Leu Ser Asn Lys Tyr Gln Thr Ala Val Lys Glu Arg Met His Arg 
        355                 360                 365             


Val Asp Pro Asn Ser Gln Ile Leu Val Phe Asp Pro Ser Thr Glu Leu 
    370                 375                 380                 


Glu Val Glu Val Val Val His Ser Ser Gly Thr Ile Trp Asn Lys Ala 
385                 390                 395                 400 


Asp Gly Val Asp Arg Leu Ile Lys Ser Leu Gly Asp Ser Leu Ser Thr 
                405                 410                 415     


Gln Gly Lys Ile Leu Ile Cys Gly Asp Thr Leu Ser Asp Ile Pro Met 
            420                 425                 430         


Val Arg Gln Ala Ala Lys Gln Asn Pro Glu Gly Val Met Ala Ile Phe 
        435                 440                 445             


Val Gly Thr Lys Val Ser Leu Arg Glu Glu Val Lys Gln Val Val Gly 
    450                 455                 460                 


Asp Glu Ser Arg Cys Cys Phe Val Ser Cys Pro Asp Val Ile His Ala 
465                 470                 475                 480 


Ala Ile Ser Gln Ile Leu Asn Glu Gln Cys Ile Val Glu Arg Ser Thr 
                485                 490                 495     


Ser Gly Asn Ser Glu Lys Asn Asn Lys Met Thr Ser Glu Thr 
            500                 505                 510 


<210>  28
<211>  167
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ShTK segment of NPTS chimera

<400>  28

Lys Asp Glu Glu Cys Lys Asp Leu Tyr Tyr Gln Cys Asn Gly Met Asn 
1               5                   10                  15      


Cys Asn Asp Pro Ile Thr Glu Val Leu Cys Ala Lys Thr Cys Gly Ile 
            20                  25                  30          


Cys Gly Thr Thr Pro Ser Ala Thr Thr Asp Pro Asp Cys Asn Asp Met 
        35                  40                  45              


Phe Gly Gln Cys Ser Ile Lys Ile Cys Met Asp Pro Met Ala Glu Lys 
    50                  55                  60                  


Leu Cys Ala Lys Thr Cys Gly Phe Cys Ala Thr Thr Pro Ser Ser Thr 
65                  70                  75                  80  


Ile Ala Pro Val Cys Lys Asp Leu Leu Asp Gln Cys Asp Asn Met Asn 
                85                  90                  95      


Cys Ser Asn Leu Phe Ala Lys Glu Leu Cys Ala Lys Thr Cys Lys Phe 
            100                 105                 110         


Cys Asp Asp Asp Leu Thr Pro Ser Pro Glu Glu Cys Asn Cys Leu Cys 
        115                 120                 125             


Lys Ile Leu Gln Pro Leu Cys Lys Phe Val Glu Trp Ile Asp Gly Ser 
    130                 135                 140                 


Phe Pro Asp Gly Phe Cys Ser Arg Cys Gln Lys Cys Lys Glu Gln Lys 
145                 150                 155                 160 


Leu Ile Ser Glu Glu Asp Leu 
                165         


<210>  29
<211>  1208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NPTS Chimera with 5' Murine IgK chain leader and 3' C-myc tag

<400>  29

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ser Lys Ile Gly Ser Val Arg Gln Gln Leu Leu 
            20                  25                  30          


Arg Ala Gly Lys Leu Lys Gln Phe Asn Asn Leu Ile Gln Ser Leu Leu 
        35                  40                  45              


Lys Glu Asn Gly Ile Val Asp Phe Phe Glu Tyr Met Asp Asn Ile Tyr 
    50                  55                  60                  


Val Ile Asn Val Thr Ile Gly Thr Pro Pro Gln His Phe Glu Ile Val 
65                  70                  75                  80  


Pro Asp Thr Gly Ser Ser Asp Leu Trp Val Ile Ser Ile Lys Cys Asn 
                85                  90                  95      


Ser Gln Ser Cys Lys Gly Asp Lys Leu His Pro Lys Asn Arg Phe Asp 
            100                 105                 110         


Pro Ser Lys Ser Ser Thr Tyr Ser Val Asp Gly Arg Lys Phe Thr Ile 
        115                 120                 125             


Thr Tyr Glu Leu Gly Tyr Ala Glu Gly Ile Leu Gly Ile Asp His Phe 
    130                 135                 140                 


Ser Phe Ala Asp Leu Ala Val Glu Met Gln Thr Phe Gly Leu Ala Glu 
145                 150                 155                 160 


Gln Ile Ala His Val Phe Gly Asp Ile Pro Ile Asp Gly Ile Met Gly 
                165                 170                 175     


Leu Ala Trp Pro Ala Leu Ser Glu Phe Gln Val Thr Pro Pro Met Gln 
            180                 185                 190         


Asn Ile Leu Asp Glu Leu Asp Glu Pro Ile Met Thr Val Tyr Met Thr 
        195                 200                 205             


Arg Glu Ile Glu Pro Ile Met Glu Glu Val Tyr Gly Gly Glu Ile Thr 
    210                 215                 220                 


Phe Gly Gly Phe Asp Glu Gln Asn Cys Glu Leu Pro Ile Arg Trp Val 
225                 230                 235                 240 


Glu Leu Thr Ser Gln Ser Phe Trp Gln Phe Thr Val Thr Gly Val Arg 
                245                 250                 255     


Val Gln Ser Tyr Lys Asn Thr Asn Trp Leu Gln Gly Ile Ser Asp Thr 
            260                 265                 270         


Gly Thr Ser Tyr Leu Ile Ile Pro Thr Phe Leu Met Lys Pro Ile Ile 
        275                 280                 285             


Lys Lys Ile Asn Ala Thr Phe Ser Phe Asp Tyr Asp Ala Tyr Val Leu 
    290                 295                 300                 


Asp Cys Ser Met Arg Asn Thr Gly Pro Asn Ile Glu Ile Ala Ile Ser 
305                 310                 315                 320 


Gly Leu Tyr Tyr Ser Ile Pro Pro Glu Gln Tyr Ile Leu Gln Tyr Ile 
                325                 330                 335     


Asp Glu Ser Gly Ser Pro Val Cys Ile Phe Ala Ala Phe Glu Asn Phe 
            340                 345                 350         


Gly Val Gly Phe Ser Pro Ala Trp Ile Leu Gly Asp Val Phe Ile Arg 
        355                 360                 365             


Ser Tyr Cys Asn Val His Asp Tyr Val Asn Asn Arg Ile Gly Phe Ala 
    370                 375                 380                 


Lys Ser Tyr Phe Gln Gln Gly Ser Ser Gly Ser Gly Trp Ala Ala Tyr 
385                 390                 395                 400 


Ile Lys Asn Leu Leu Asp Ser Ser Gln Gly Ile Gln Arg Ala Ala Ile 
                405                 410                 415     


Val Gly Tyr Pro Asp Gly Ser Val Trp Ala Arg Ser Glu Gly Asp Arg 
            420                 425                 430         


Glu Phe Arg Ala Thr Asp Glu Glu Leu Lys Lys Phe Val Ser Leu Tyr 
        435                 440                 445             


Asp His Ile Glu Lys Val Pro Ala Thr Gly Cys Asp Leu Glu Gly Val 
    450                 455                 460                 


His Tyr Ile Val Pro Arg Thr Glu Gln Asn Leu Ile Phe Gly Lys Arg 
465                 470                 475                 480 


Asp Lys Thr Gly Ile Phe Ala Ala Lys Thr Lys Ser Ala Val Leu Ile 
                485                 490                 495     


Ala Cys Tyr Lys Gly Glu Asn Ala Ala Glu Val Arg Val Ala Val Glu 
            500                 505                 510         


Lys Leu Ala Gln Tyr Leu Met Asp Ser Gly Tyr Gly Ser Ser Gly Thr 
        515                 520                 525             


Glu Thr Ile Ala Asp Gln Glu Lys Gln Lys Asn Thr Lys Leu Glu Lys 
    530                 535                 540                 


His Glu Ala Ala Lys Asp Glu Pro Ala Glu Glu Lys Glu Arg Glu Arg 
545                 550                 555                 560 


Glu Thr Pro Gly Ser Gly Thr Ala Lys Asn Thr Glu Gln Asn Leu Ser 
                565                 570                 575     


Leu Ser Leu Glu Gln Thr Gly Ile Ile Lys Asn Asp Asn Val Gln Thr 
            580                 585                 590         


Ile Asp Asp Phe Lys Asp Leu Met Tyr Lys Met Gln Glu Thr Arg Arg 
        595                 600                 605             


Ala Ile Val Val Ala Leu Leu Asn Glu Lys Asp Leu Lys Asn Asp Asp 
    610                 615                 620                 


Ile Glu Ile Leu Arg Arg Ala Tyr Glu Lys Leu Thr Asp Asn Gln Thr 
625                 630                 635                 640 


His Ser Phe Gln Arg Glu Met Cys Thr Leu Thr Thr Lys Leu Ser Val 
                645                 650                 655     


Asn Ile Arg Asp Glu Thr Arg Gly Leu Glu Lys Asp Leu Lys Tyr Leu 
            660                 665                 670         


Glu Ile Leu Thr His Ile Arg Gly Glu Glu Pro Ser Leu Ser Trp Pro 
        675                 680                 685             


Val Val Met Ser Arg Leu Asp Leu Ile Ser Ile Leu Ser Asn Tyr His 
    690                 695                 700                 


Pro Glu Gly Lys Glu Lys Phe Met Lys Glu Tyr Glu Asn Thr Val Arg 
705                 710                 715                 720 


Phe Leu His Thr Phe Ile Gly Ser Glu Ala Ile Thr Gly Lys Lys Pro 
                725                 730                 735     


Ile Phe Ile Thr Asp Trp Asp Gly Thr Met Lys Asp Tyr Cys Ser Gln 
            740                 745                 750         


Tyr Ala Thr Asn Leu Gln Pro Val Tyr Ser Ala Val Gly Met Ile Arg 
        755                 760                 765             


Phe Ala Asp Arg Phe Thr Arg Ile Ser Ala Val Leu Thr Ala Gly Pro 
    770                 775                 780                 


Leu Arg Gly Pro Gly Ile Leu Asp Leu Thr Ala Met Pro Ile Asp Gly 
785                 790                 795                 800 


Pro Val Met Phe Ser Gly Ser Trp Gly Arg Glu Trp Trp Leu Ser Gly 
                805                 810                 815     


Lys Arg Val Val His Glu Asp Gly Ile Thr Asp Ala Gly Phe Asn Ala 
            820                 825                 830         


Leu Gln Arg Leu Asp Asp Glu Met Lys Asp Leu Leu His Ser Ser Asp 
        835                 840                 845             


Tyr Ala Pro Phe Ala Leu Val Gly Ser Gly Val Gln Arg Lys Val Asp 
    850                 855                 860                 


Arg Leu Thr Leu Gly Val Gln Thr Val Cys His His Val Thr Ser Glu 
865                 870                 875                 880 


Leu Ser Asn Lys Tyr Gln Thr Ala Val Lys Glu Arg Met His Arg Val 
                885                 890                 895     


Asp Pro Asn Ser Gln Ile Leu Val Phe Asp Pro Ser Thr Glu Leu Glu 
            900                 905                 910         


Val Glu Val Val Val His Ser Ser Gly Thr Ile Trp Asn Lys Ala Asp 
        915                 920                 925             


Gly Val Asp Arg Leu Ile Lys Ser Leu Gly Asp Ser Leu Ser Thr Gln 
    930                 935                 940                 


Gly Lys Ile Leu Ile Cys Gly Asp Thr Leu Ser Asp Ile Pro Met Val 
945                 950                 955                 960 


Arg Gln Ala Ala Lys Gln Asn Pro Glu Gly Val Met Ala Ile Phe Val 
                965                 970                 975     


Gly Thr Lys Val Ser Leu Arg Glu Glu Val Lys Gln Val Val Gly Asp 
            980                 985                 990         


Glu Ser Arg Cys Cys Phe Val Ser  Cys Pro Asp Val Ile  His Ala Ala 
        995                 1000                 1005             


Ile Ser  Gln Ile Leu Asn Glu  Gln Cys Ile Val Glu  Arg Ser Thr 
    1010                 1015                 1020             


Ser Gly  Asn Ser Glu Lys Asn  Asn Lys Met Thr Ser  Glu Thr Gly 
    1025                 1030                 1035             


Ser Ser  Gly Lys Asp Glu Glu  Cys Lys Asp Leu Tyr  Tyr Gln Cys 
    1040                 1045                 1050             


Asn Gly  Met Asn Cys Asn Asp  Pro Ile Thr Glu Val  Leu Cys Ala 
    1055                 1060                 1065             


Lys Thr  Cys Gly Ile Cys Gly  Thr Thr Pro Ser Ala  Thr Thr Asp 
    1070                 1075                 1080             


Pro Asp  Cys Asn Asp Met Phe  Gly Gln Cys Ser Ile  Lys Ile Cys 
    1085                 1090                 1095             


Met Asp  Pro Met Ala Glu Lys  Leu Cys Ala Lys Thr  Cys Gly Phe 
    1100                 1105                 1110             


Cys Ala  Thr Thr Pro Ser Ser  Thr Ile Ala Pro Val  Cys Lys Asp 
    1115                 1120                 1125             


Leu Leu  Asp Gln Cys Asp Asn  Met Asn Cys Ser Asn  Leu Phe Ala 
    1130                 1135                 1140             


Lys Glu  Leu Cys Ala Lys Thr  Cys Lys Phe Cys Asp  Asp Asp Leu 
    1145                 1150                 1155             


Thr Pro  Ser Pro Glu Glu Cys  Asn Cys Leu Cys Lys  Ile Leu Gln 
    1160                 1165                 1170             


Pro Leu  Cys Lys Phe Val Glu  Trp Ile Asp Gly Ser  Phe Pro Asp 
    1175                 1180                 1185             


Gly Phe  Cys Ser Arg Cys Gln  Lys Cys Lys Glu Gln  Lys Leu Ile 
    1190                 1195                 1200             


Ser Glu  Glu Asp Leu 
    1205             


<210>  30
<211>  1107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Necepsin segment of NPTS chimera

<400>  30
tccaaaatag gctcggtccg ccaacaactg ctgcgtgccg gtaaactcaa gcaattcaat       60

aacctcatac agtcgcttct taaagagaat ggtatcgtgg acttcttcga atacatggac      120

aacatctatg tgataaatgt gaccattggt acaccaccgc agcactttga gattgttccc      180

gacaccggct cctctgatct atgggtgatt tctatcaagt gcaactcgca aagctgtaag      240

ggcgacaagc tccaccccaa gaacaggttc gacccatcca aaagttccac atactcagtc      300

gacggtcgaa aattcacaat tacgtacgaa ctgggatacg ccgaaggcat cctgggtatc      360

gaccacttca gtttcgctga tctggcggtt gagatgcaga cttttggttt agccgaacaa      420

atcgcccacg tattcggcga tatcccgata gacggcatca tgggtctagc gtggccagcc      480

ctttccgagt ttcaggtgac tccgccaatg caaaacatac tggatgaact agatgaacct      540

atcatgaccg tttacatgac acgcgagata gagcccatca tggaggaggt ctatggaggt      600

gaaatcacct tcggtggctt cgacgagcag aactgcgaac tgcctatccg ctgggtggaa      660

ctcacttcac agtccttctg gcagttcacg gtgaccggcg tacgtgttca gtcatataag      720

aacactaatt ggctgcaagg aattagcgac acaggaactt cttacttgat catccccaca      780

ttcttgatga agcccattat aaagaaaatt aacgcaactt tcagctttga ctacgacgct      840

tatgtcctcg attgcagtat gcgcaacacg ggtccgaaca ttgagatcgc aatttcgggc      900

ttgtattaca gcattccacc tgagcagtac attctgcagt atatcgatga gtctggctca      960

ccagtgtgca tctttgcagc attcgagaac ttcggcgtcg gcttctcacc cgcatggata     1020

cttggtgatg tgttcatccg ctcgtactgc aatgtgcatg attacgtgaa caaccgcata     1080

ggtttcgcaa agtcctactt ccaacaa                                         1107


<210>  31
<211>  387
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Prof2 segment of NPTS chimera

<400>  31
tcgggttggg cggcctatat caagaacctt ctggattcca gccaaggaat acaacgtgca       60

gccatcgtag gatatcctga cggtagtgta tgggccagat ctgaaggcga ccgcgagttc      120

agagctaccg atgaggaact gaagaagttc gtgtctctgt acgatcacat cgagaaggtg      180

cctgcgacag gctgtgacct cgaaggagtt cactatatcg ttcctaggac tgaacaaaac      240

ttgatcttcg gaaagagaga caagacaggt attttcgctg ccaagacgaa gtcagccgtt      300

ttgatagcct gctacaaagg agagaatgct gcagaggtca gggtagctgt ggaaaagcta      360

gctcagtacc ttatggactc cggttac                                          387


<210>  32
<211>  1530
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP segment of NPTS chimera

<400>  32
accgaaacca ttgccgatca agaaaagcag aagaacacca aattggagaa gcatgaggcg       60

gctaaggacg aaccagcaga agagaaagag cgtgaaagag agactcccgg aagcggtacc      120

gcgaagaaca ccgaacagaa tctgagcctt tccctggagc aaacaggtat tatcaaaaac      180

gataacgtcc agaccattga tgactttaag gacttgatgt acaagatgca agagacaaga      240

agagccattg tagtagcgct gttgaatgaa aaggacttaa agaatgacga catcgagatt      300

ctgcgccgtg cctatgagaa gcttactgat aatcagaccc actcgtttca gcgcgagatg      360

tgtacgttaa caactaagtt gtctgtcaac attcgagatg agacaagggg cctcgaaaag      420

gacttgaaat atctggagat cctcacccat attcgtggtg aggaaccatc actctcctgg      480

ccagtggtta tgtctcgctt ggacctaatc tctattctgt ctaactacca tccggaggga      540

aaggagaaat tcatgaagga atacgaaaac acggtccgct tcttgcacac cttcatcggc      600

tcagaggcta tcaccggtaa gaagccgatc ttcatcactg attgggacgg caccatgaaa      660

gactactgct cacagtacgc gactaacttg cagcctgtct actccgctgt tggtatgatt      720

cgcttcgctg accgatttac tcgcatcagt gctgtgttga ccgcaggacc tctcagggga      780

cccggaatct tagacctgac ggcgatgcct atagacggtc cagtcatgtt ctcaggtagc      840

tggggaaggg agtggtggct ctctggcaaa agagtagtgc atgaggacgg tatcactgac      900

gcgggattca acgctttgca acgtttagac gatgagatga aagacttgct tcatagcagt      960

gattacgcac catttgctct ggtgggttcc ggagttcagc gcaaggttga caggctgacc     1020

ttaggagtac agactgtatg ccaccacgtt acttcagaac taagcaacaa ataccaaact     1080

gcggtcaagg aacgtatgca ccgtgtagac cccaatagtc agatccttgt gtttgaccca     1140

tctacggagt tggaagtcga ggtggtggtc catagctcgg gtactatctg gaataaggct     1200

gacggtgtcg atcgattgat caagtctctt ggagattcgt tatcaaccca aggcaaaata     1260

ctcatttgcg gagacacact gagcgacata cctatggtca ggcaagctgc caagcagaac     1320

cctgaaggtg ttatggccat cttcgtcgga acgaaggttt cgctgcgtga agaagtgaaa     1380

caagtcgtcg gtgacgagag cagatgctgc ttcgttagct gcccggatgt gattcacgcc     1440

gccatcagcc agatcctgaa tgaacagtgt atcgtcgaga ggtctacaag tggtaactcc     1500

gagaagaaca acaaaatgac ctccgagaca                                      1530


<210>  33
<211>  471
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ShTK segment of NPTS chimera

<400>  33
aaggatgaag agtgcaaaga tctgtactac cagtgtaacg gaatgaattg caacgatcca       60

atcaccgaag tactctgtgc taagacgtgc ggtatctgcg gaactacacc ttccgctaca      120

acagatccgg actgcaatga tatgtttggt cagtgttcta ttaagatctg catggacccc      180

atggcagaga agctgtgtgc taaaacctgt ggcttttgcg ctactacccc atcatccacg      240

attgcccctg tgtgtaaaga cctcctcgat cagtgcgata atatgaactg ctccaacctc      300

ttcgctaagg aactatgtgc taaaacgtgt aaattctgcg atgacgacct gacgcccagt      360

cccgaagagt gcaactgtct atgtaaaatc cttcaacccc tctgcaagtt tgtggaatgg      420

atcgacggta gtttccctga cggtttctgt tcacgttgtc agaaatgcaa g               471


<210>  34
<211>  3624
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NPTS Chimera with 5' Murine IgK chain leader and 3' C-myc tag

<400>  34
atggaaacgg ataccctgct cctctgggta ttattactct gggtccccgg aagtactggc       60

gactccaaaa taggctcggt ccgccaacaa ctgctgcgtg ccggtaaact caagcaattc      120

aataacctca tacagtcgct tcttaaagag aatggtatcg tggacttctt cgaatacatg      180

gacaacatct atgtgataaa tgtgaccatt ggtacaccac cgcagcactt tgagattgtt      240

cccgacaccg gctcctctga tctatgggtg atttctatca agtgcaactc gcaaagctgt      300

aagggcgaca agctccaccc caagaacagg ttcgacccat ccaaaagttc cacatactca      360

gtcgacggtc gaaaattcac aattacgtac gaactgggat acgccgaagg catcctgggt      420

atcgaccact tcagtttcgc tgatctggcg gttgagatgc agacttttgg tttagccgaa      480

caaatcgccc acgtattcgg cgatatcccg atagacggca tcatgggtct agcgtggcca      540

gccctttccg agtttcaggt gactccgcca atgcaaaaca tactggatga actagatgaa      600

cctatcatga ccgtttacat gacacgcgag atagagccca tcatggagga ggtctatgga      660

ggtgaaatca ccttcggtgg cttcgacgag cagaactgcg aactgcctat ccgctgggtg      720

gaactcactt cacagtcctt ctggcagttc acggtgaccg gcgtacgtgt tcagtcatat      780

aagaacacta attggctgca aggaattagc gacacaggaa cttcttactt gatcatcccc      840

acattcttga tgaagcccat tataaagaaa attaacgcaa ctttcagctt tgactacgac      900

gcttatgtcc tcgattgcag tatgcgcaac acgggtccga acattgagat cgcaatttcg      960

ggcttgtatt acagcattcc acctgagcag tacattctgc agtatatcga tgagtctggc     1020

tcaccagtgt gcatctttgc agcattcgag aacttcggcg tcggcttctc acccgcatgg     1080

atacttggtg atgtgttcat ccgctcgtac tgcaatgtgc atgattacgt gaacaaccgc     1140

ataggtttcg caaagtccta cttccaacaa ggctcctcag gttcgggttg ggcggcctat     1200

atcaagaacc ttctggattc cagccaagga atacaacgtg cagccatcgt aggatatcct     1260

gacggtagtg tatgggccag atctgaaggc gaccgcgagt tcagagctac cgatgaggaa     1320

ctgaagaagt tcgtgtctct gtacgatcac atcgagaagg tgcctgcgac aggctgtgac     1380

ctcgaaggag ttcactatat cgttcctagg actgaacaaa acttgatctt cggaaagaga     1440

gacaagacag gtattttcgc tgccaagacg aagtcagccg ttttgatagc ctgctacaaa     1500

ggagagaatg ctgcagaggt cagggtagct gtggaaaagc tagctcagta ccttatggac     1560

tccggttacg gctcgtcagg caccgaaacc attgccgatc aagaaaagca gaagaacacc     1620

aaattggaga agcatgaggc ggctaaggac gaaccagcag aagagaaaga gcgtgaaaga     1680

gagactcccg gaagcggtac cgcgaagaac accgaacaga atctgagcct ttccctggag     1740

caaacaggta ttatcaaaaa cgataacgtc cagaccattg atgactttaa ggacttgatg     1800

tacaagatgc aagagacaag aagagccatt gtagtagcgc tgttgaatga aaaggactta     1860

aagaatgacg acatcgagat tctgcgccgt gcctatgaga agcttactga taatcagacc     1920

cactcgtttc agcgcgagat gtgtacgtta acaactaagt tgtctgtcaa cattcgagat     1980

gagacaaggg gcctcgaaaa ggacttgaaa tatctggaga tcctcaccca tattcgtggt     2040

gaggaaccat cactctcctg gccagtggtt atgtctcgct tggacctaat ctctattctg     2100

tctaactacc atccggaggg aaaggagaaa ttcatgaagg aatacgaaaa cacggtccgc     2160

ttcttgcaca ccttcatcgg ctcagaggct atcaccggta agaagccgat cttcatcact     2220

gattgggacg gcaccatgaa agactactgc tcacagtacg cgactaactt gcagcctgtc     2280

tactccgctg ttggtatgat tcgcttcgct gaccgattta ctcgcatcag tgctgtgttg     2340

accgcaggac ctctcagggg acccggaatc ttagacctga cggcgatgcc tatagacggt     2400

ccagtcatgt tctcaggtag ctggggaagg gagtggtggc tctctggcaa aagagtagtg     2460

catgaggacg gtatcactga cgcgggattc aacgctttgc aacgtttaga cgatgagatg     2520

aaagacttgc ttcatagcag tgattacgca ccatttgctc tggtgggttc cggagttcag     2580

cgcaaggttg acaggctgac cttaggagta cagactgtat gccaccacgt tacttcagaa     2640

ctaagcaaca aataccaaac tgcggtcaag gaacgtatgc accgtgtaga ccccaatagt     2700

cagatccttg tgtttgaccc atctacggag ttggaagtcg aggtggtggt ccatagctcg     2760

ggtactatct ggaataaggc tgacggtgtc gatcgattga tcaagtctct tggagattcg     2820

ttatcaaccc aaggcaaaat actcatttgc ggagacacac tgagcgacat acctatggtc     2880

aggcaagctg ccaagcagaa ccctgaaggt gttatggcca tcttcgtcgg aacgaaggtt     2940

tcgctgcgtg aagaagtgaa acaagtcgtc ggtgacgaga gcagatgctg cttcgttagc     3000

tgcccggatg tgattcacgc cgccatcagc cagatcctga atgaacagtg tatcgtcgag     3060

aggtctacaa gtggtaactc cgagaagaac aacaaaatga cctccgagac aggcagtagc     3120

ggcaaggatg aagagtgcaa agatctgtac taccagtgta acggaatgaa ttgcaacgat     3180

ccaatcaccg aagtactctg tgctaagacg tgcggtatct gcggaactac accttccgct     3240

acaacagatc cggactgcaa tgatatgttt ggtcagtgtt ctattaagat ctgcatggac     3300

cccatggcag agaagctgtg tgctaaaacc tgtggctttt gcgctactac cccatcatcc     3360

acgattgccc ctgtgtgtaa agacctcctc gatcagtgcg ataatatgaa ctgctccaac     3420

ctcttcgcta aggaactatg tgctaaaacg tgtaaattct gcgatgacga cctgacgccc     3480

agtcccgaag agtgcaactg tctatgtaaa atccttcaac ccctctgcaa gtttgtggaa     3540

tggatcgacg gtagtttccc tgacggtttc tgttcacgtt gtcagaaatg caaggaacag     3600

aagttgatct ctgaagagga cctg                                            3624


<210>  35
<211>  644
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Reprolysine segment of Reprolysin-Mrp5-Nas4 (RMN) chimera

<400>  35

His His Asp Ile Tyr Cys Pro Leu His Ile Tyr Phe Gly Glu His Glu 
1               5                   10                  15      


Leu Asp Ala Asn Gln Leu Ile Ser Ile Ser Gln Thr Ile Gln Pro Lys 
            20                  25                  30          


Phe Glu Leu Thr Leu Gln Asn Asp Phe Gly Glu Ser Arg Asp Phe Ile 
        35                  40                  45              


Phe Gln Ser Asn Arg Glu Leu Ser Lys Thr Ser Ser Lys Ile Asp Met 
    50                  55                  60                  


Leu Cys His Phe Glu Gly Ile Ser Asn Thr Gly Glu His Ser Ala Met 
65                  70                  75                  80  


Ser Thr Cys Ser Met Ser Leu Leu Gly Gly Leu Phe Thr Ile Asn Gly 
                85                  90                  95      


Arg Arg Phe Val Leu Glu Val Gly Leu Asn Ala Leu Phe His Phe Val 
            100                 105                 110         


Pro Leu Ser Asp His Ser Cys Asp Trp Gly Leu Arg Ser Lys Arg Ser 
        115                 120                 125             


Ile Ala Gly Ser His Val Ala Glu Tyr Tyr Ala Gln Phe Leu Asp Gly 
    130                 135                 140                 


Arg Trp Arg Tyr Val Glu Leu Ala Leu Ile Ala Asp Lys Leu Val Phe 
145                 150                 155                 160 


Glu Lys Tyr His Lys Asn Val Thr Glu Val Met Gln Arg Leu Asn Ala 
                165                 170                 175     


Ile Thr Asn Tyr Ile Asn Ser Leu Tyr Leu Pro Ile Asn Ile Arg Val 
            180                 185                 190         


Val Leu Val Trp Ala Asp Val Trp Thr Asn Asp Asn Pro Val Asp Ile 
        195                 200                 205             


Thr Ser Asn Ser Asp Thr Thr Leu Trp Asn Phe Leu Asn Trp Arg Lys 
    210                 215                 220                 


Gly Leu Leu Lys Asp His Pro His Asp Asn Ala His Leu Leu Thr Gly 
225                 230                 235                 240 


Val Ile Phe Glu Asn Asn Val Val Gly Lys Ala Phe Lys Gly Thr Met 
                245                 250                 255     


Cys Ser Tyr Asp Phe Ser Gly Gly Val Asp Ile Glu His Ser Asp Gln 
            260                 265                 270         


Ala Ala Tyr Val Ala Ala Thr Ile Ala His Glu Met Gly His Asn Phe 
        275                 280                 285             


Gly Met Glu His Asp Ile Asp Glu Ile Glu Cys Arg Cys Pro Ala Lys 
    290                 295                 300                 


Ser Cys Ile Met Ser Pro Ala Thr Gly Ile Thr His Pro Thr Phe Trp 
305                 310                 315                 320 


Ser Glu Cys Ser Met Arg Ala Leu Gln His Ser Phe Ser Arg Gly Val 
                325                 330                 335     


Asp Tyr Cys Leu Arg Asn Ser Pro Thr Ser Val Phe Gly Gly Ala Arg 
            340                 345                 350         


Cys Gly Asn Gly Ile Val Glu Ala Gly Glu Glu Cys Asp Cys Gly Thr 
        355                 360                 365             


Pro Ser Ser Cys Ile Asn Lys Cys Cys Asn Pro Ala Thr Cys Arg Leu 
    370                 375                 380                 


Ser Glu Thr Ala Val Cys Ala Thr Gly Glu Cys Cys Asp Leu Asn Thr 
385                 390                 395                 400 


Cys Gln Leu Leu Ser Ala Thr Thr Val Cys Arg Gln Ala Thr Asn Glu 
                405                 410                 415     


Cys Asp Leu Pro Glu Tyr Cys Asp Gly Leu Met Glu His Cys Pro Ala 
            420                 425                 430         


Asp Phe Phe Val Gln Asp Gly His Glu Cys Pro Asn His Val Asp Asp 
        435                 440                 445             


Tyr Cys Tyr Asn Gly Tyr Cys Gly Ser Arg Asp Ala Gln Cys Gln His 
    450                 455                 460                 


Ile Trp Gly Ser Thr Gly Arg Asn Ala Ala Pro Ala Cys Tyr Asp Leu 
465                 470                 475                 480 


Asn Leu Ser Gly Ser Ser Gly Gly Asn Cys Gly Phe Leu His Glu Thr 
                485                 490                 495     


Asn Arg Phe Val Pro Cys Asn Lys Asn Asp Ile Lys Cys Gly Arg Leu 
            500                 505                 510         


His Cys Ile His Glu Asn Glu Lys Leu Val Phe Gly Asp Pro Ser Thr 
        515                 520                 525             


Val Tyr Thr Ala Tyr Thr Gly Leu Arg Leu Arg Asn Gly Glu Asp Val 
    530                 535                 540                 


Ala Cys Arg Val Ile Trp Thr Lys Tyr Ile Ser Gly Gln Lys Glu Pro 
545                 550                 555                 560 


Asp Pro Gly Met Val Pro Asn Gly Ala Val Cys Gly Gln Asp Glu Met 
                565                 570                 575     


Cys Val Asp Ala Lys Cys Gln Asn Arg Thr Ala Lys Val Leu Met Ala 
            580                 585                 590         


Pro Lys Cys Glu Pro Val Ser Cys Asn Asn Ala Gly Ile Cys Asn Asn 
        595                 600                 605             


Met Gly Asn Cys His Cys Asp Pro Gly Tyr Gly Gly Ser Ser Cys Ala 
    610                 615                 620                 


Ile Pro Gly Pro Gly Gly Ser Val Asn Ser Gly Pro Ala Ile Glu Gly 
625                 630                 635                 640 


Gly Val Ile His 
                


<210>  36
<211>  397
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mrp5 segment of Reprolysin-Mrp5-Nas4 (RMN) chimera

<400>  36

Thr Gly Ser Ile Ala Pro Ala Asp Ala Gly Met Ala Leu Val Phe Ala 
1               5                   10                  15      


Leu Gln Met Ser Gly Ile Phe Gln Phe Ala Val Arg Thr Gln Thr Glu 
            20                  25                  30          


Leu Glu Ala Lys Met Thr Cys Val Glu Arg Val Thr Tyr Tyr Ser Asp 
        35                  40                  45              


His Ile Lys Ser Glu Asp Gly Trp Asn Asn Gly Ile Gly Asp Ser Ser 
    50                  55                  60                  


Arg Asn Asp Ser Phe Pro Asn Gly Cys Ile Val Phe Arg Gly Val Ser 
65                  70                  75                  80  


Leu Arg Tyr Arg Pro Asp Leu Pro Leu Ala Leu Asp Asp Val Asn Phe 
                85                  90                  95      


Arg Ile Glu Pro Lys Glu Lys Ile Gly Ile Ile Gly Arg Thr Gly Ser 
            100                 105                 110         


Gly Lys Thr Ser Leu Cys Asn Ala Leu Tyr Arg Leu Tyr Pro Leu Thr 
        115                 120                 125             


Ser Gly Ser Ile Glu Ile Asp Gly Ile Asn Ile Ala Cys Ile Gly Leu 
    130                 135                 140                 


Tyr Arg Leu Arg Arg Ala Met Ala Val Ile Pro Gln Asp Pro Thr Leu 
145                 150                 155                 160 


Phe Val Gly Thr Ile Arg Phe Asn Ile Asp Pro Asn Asn Glu Phe Thr 
                165                 170                 175     


Asp Asp Gln Ile Trp Met Ser Leu Glu Lys Thr Tyr Leu Lys Asp Met 
            180                 185                 190         


Val Ser Ser Leu Asp Arg Lys Leu Asp Ser Pro Val Thr Glu Gly Gly 
        195                 200                 205             


Arg Asn Leu Ser Val Gly Glu Arg Gln Leu Phe Cys Met Ala Arg Ala 
    210                 215                 220                 


Leu Leu Arg Gln Val Arg Ile Val Val Leu Asp Glu Ala Thr Gly Ser 
225                 230                 235                 240 


Leu Asp Asn Ala Thr Asp Arg His Ile Gln Lys Cys Leu Arg Glu Ala 
                245                 250                 255     


Phe Val Gly Cys Thr Val Met Ile Ile Ala His Arg Leu Glu Asn Val 
            260                 265                 270         


Leu Gly Leu Asp Lys Ile Leu His Met Lys Gln Gly Lys Ile Val Lys 
        275                 280                 285             


Tyr Asp Thr Ile Gln Asn Leu Ile Arg Asp Gln Asn His Pro Leu Arg 
    290                 295                 300                 


Arg Leu Leu Asp Asn Gln Lys Leu Arg Arg Val Ile Arg Thr Gln Lys 
305                 310                 315                 320 


Glu Gln Ser Thr Lys Lys Asn Leu Glu Gln Ser Ser Lys Ile Ser Pro 
                325                 330                 335     


Asn Glu Ser Ser Gly Ser Ser Pro Glu Arg Ile His Ser Thr Phe Leu 
            340                 345                 350         


Ala Ser Asp Lys Thr Ser Pro Glu Thr Ser Glu Phe Glu Lys Ile Ser 
        355                 360                 365             


Asp Ser Ile Asp Lys Glu Ile Thr Thr Met Ser Asn Asp Asn Ser Asp 
    370                 375                 380                 


Leu Glu Val Ile Asn Lys Ser Asp Ala Glu Ser Asn Cys 
385                 390                 395         


<210>  37
<211>  298
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nas4 segment of Reprolysin-Mrp5-Nas4 (RMN) chimera

<400>  37

Ser Lys Leu Asp Ile Lys Leu Glu Asp Ile Ile Asn Glu Lys Ala Val 
1               5                   10                  15      


Glu Glu Glu Thr Thr Leu Thr Ala Glu Asp Phe Glu Lys Thr Ile Asp 
            20                  25                  30          


Glu Glu Phe Asn Leu Thr Leu Leu Gly Ile Gln Met Lys Pro Asp Pro 
        35                  40                  45              


Thr Met Gly Asn Met Thr Glu Gly Asp Ile Val Leu Pro Asn Phe Lys 
    50                  55                  60                  


Ala Phe Ala Asp Tyr Arg Asn Asn Arg Thr Glu Arg Ser Ala Ala Arg 
65                  70                  75                  80  


His Ile Tyr Arg Arg Trp Pro Asn Ala Glu Ile Pro Tyr Ala Leu Ser 
                85                  90                  95      


Ser Arg Tyr Gly Ala Tyr Ser Arg Ser Val Ile Ala Lys Ala Met Lys 
            100                 105                 110         


Lys Phe His Asp Ile Ser Cys Val Arg Phe Val Pro Arg Val Tyr Asn 
        115                 120                 125             


Gln His Asp Asp Tyr Ile Tyr Ile Phe Pro His Asp Gly Cys Tyr Ser 
    130                 135                 140                 


Phe Val Gly Arg Ser Gly Gly Arg Gln Pro Val Ser Leu Glu Ala Asn 
145                 150                 155                 160 


Cys Ile Gln Ser Gly Thr Ile Ile His Glu Leu Met His Val Val Gly 
                165                 170                 175     


Phe Phe His Glu Gln Ser Arg Pro Asp Arg Asp Glu Tyr Ile Glu Ile 
            180                 185                 190         


Met Trp Gln Asn Val Ile Arg Gly Ser Glu Asn Gln Phe Asp Lys Gln 
        195                 200                 205             


Ser Leu Arg Tyr Leu Asp Pro Leu Asn Glu Ser Tyr Asp Tyr Ser Ser 
    210                 215                 220                 


Ile Met His Tyr Gly Pro Tyr Ala Phe Ser Gly Asn Gly Arg Arg Thr 
225                 230                 235                 240 


Ile Ile Ala Leu Lys Pro Gly Ala Gly Lys Met Gly Gln Arg Glu Ser 
                245                 250                 255     


Leu Thr Glu Ile Asp Ile Arg Lys Ile Asn Lys Leu Tyr His Cys Gln 
            260                 265                 270         


Gln Lys Ser Thr Gln Glu Asn Ser Ile Glu Asp Asn Val Glu Ile Thr 
        275                 280                 285             


Lys Ser Ile Val Pro Leu Lys Pro Ile Asn 
    290                 295             


<210>  38
<211>  1378
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RMN Chimera with 5' Murine IgK chain leader and 3' C-myc tag

<400>  38

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp His His Asp Ile Tyr Cys Pro Leu His Ile Tyr 
            20                  25                  30          


Phe Gly Glu His Glu Leu Asp Ala Asn Gln Leu Ile Ser Ile Ser Gln 
        35                  40                  45              


Thr Ile Gln Pro Lys Phe Glu Leu Thr Leu Gln Asn Asp Phe Gly Glu 
    50                  55                  60                  


Ser Arg Asp Phe Ile Phe Gln Ser Asn Arg Glu Leu Ser Lys Thr Ser 
65                  70                  75                  80  


Ser Lys Ile Asp Met Leu Cys His Phe Glu Gly Ile Ser Asn Thr Gly 
                85                  90                  95      


Glu His Ser Ala Met Ser Thr Cys Ser Met Ser Leu Leu Gly Gly Leu 
            100                 105                 110         


Phe Thr Ile Asn Gly Arg Arg Phe Val Leu Glu Val Gly Leu Asn Ala 
        115                 120                 125             


Leu Phe His Phe Val Pro Leu Ser Asp His Ser Cys Asp Trp Gly Leu 
    130                 135                 140                 


Arg Ser Lys Arg Ser Ile Ala Gly Ser His Val Ala Glu Tyr Tyr Ala 
145                 150                 155                 160 


Gln Phe Leu Asp Gly Arg Trp Arg Tyr Val Glu Leu Ala Leu Ile Ala 
                165                 170                 175     


Asp Lys Leu Val Phe Glu Lys Tyr His Lys Asn Val Thr Glu Val Met 
            180                 185                 190         


Gln Arg Leu Asn Ala Ile Thr Asn Tyr Ile Asn Ser Leu Tyr Leu Pro 
        195                 200                 205             


Ile Asn Ile Arg Val Val Leu Val Trp Ala Asp Val Trp Thr Asn Asp 
    210                 215                 220                 


Asn Pro Val Asp Ile Thr Ser Asn Ser Asp Thr Thr Leu Trp Asn Phe 
225                 230                 235                 240 


Leu Asn Trp Arg Lys Gly Leu Leu Lys Asp His Pro His Asp Asn Ala 
                245                 250                 255     


His Leu Leu Thr Gly Val Ile Phe Glu Asn Asn Val Val Gly Lys Ala 
            260                 265                 270         


Phe Lys Gly Thr Met Cys Ser Tyr Asp Phe Ser Gly Gly Val Asp Ile 
        275                 280                 285             


Glu His Ser Asp Gln Ala Ala Tyr Val Ala Ala Thr Ile Ala His Glu 
    290                 295                 300                 


Met Gly His Asn Phe Gly Met Glu His Asp Ile Asp Glu Ile Glu Cys 
305                 310                 315                 320 


Arg Cys Pro Ala Lys Ser Cys Ile Met Ser Pro Ala Thr Gly Ile Thr 
                325                 330                 335     


His Pro Thr Phe Trp Ser Glu Cys Ser Met Arg Ala Leu Gln His Ser 
            340                 345                 350         


Phe Ser Arg Gly Val Asp Tyr Cys Leu Arg Asn Ser Pro Thr Ser Val 
        355                 360                 365             


Phe Gly Gly Ala Arg Cys Gly Asn Gly Ile Val Glu Ala Gly Glu Glu 
    370                 375                 380                 


Cys Asp Cys Gly Thr Pro Ser Ser Cys Ile Asn Lys Cys Cys Asn Pro 
385                 390                 395                 400 


Ala Thr Cys Arg Leu Ser Glu Thr Ala Val Cys Ala Thr Gly Glu Cys 
                405                 410                 415     


Cys Asp Leu Asn Thr Cys Gln Leu Leu Ser Ala Thr Thr Val Cys Arg 
            420                 425                 430         


Gln Ala Thr Asn Glu Cys Asp Leu Pro Glu Tyr Cys Asp Gly Leu Met 
        435                 440                 445             


Glu His Cys Pro Ala Asp Phe Phe Val Gln Asp Gly His Glu Cys Pro 
    450                 455                 460                 


Asn His Val Asp Asp Tyr Cys Tyr Asn Gly Tyr Cys Gly Ser Arg Asp 
465                 470                 475                 480 


Ala Gln Cys Gln His Ile Trp Gly Ser Thr Gly Arg Asn Ala Ala Pro 
                485                 490                 495     


Ala Cys Tyr Asp Leu Asn Leu Ser Gly Ser Ser Gly Gly Asn Cys Gly 
            500                 505                 510         


Phe Leu His Glu Thr Asn Arg Phe Val Pro Cys Asn Lys Asn Asp Ile 
        515                 520                 525             


Lys Cys Gly Arg Leu His Cys Ile His Glu Asn Glu Lys Leu Val Phe 
    530                 535                 540                 


Gly Asp Pro Ser Thr Val Tyr Thr Ala Tyr Thr Gly Leu Arg Leu Arg 
545                 550                 555                 560 


Asn Gly Glu Asp Val Ala Cys Arg Val Ile Trp Thr Lys Tyr Ile Ser 
                565                 570                 575     


Gly Gln Lys Glu Pro Asp Pro Gly Met Val Pro Asn Gly Ala Val Cys 
            580                 585                 590         


Gly Gln Asp Glu Met Cys Val Asp Ala Lys Cys Gln Asn Arg Thr Ala 
        595                 600                 605             


Lys Val Leu Met Ala Pro Lys Cys Glu Pro Val Ser Cys Asn Asn Ala 
    610                 615                 620                 


Gly Ile Cys Asn Asn Met Gly Asn Cys His Cys Asp Pro Gly Tyr Gly 
625                 630                 635                 640 


Gly Ser Ser Cys Ala Ile Pro Gly Pro Gly Gly Ser Val Asn Ser Gly 
                645                 650                 655     


Pro Ala Ile Glu Gly Gly Val Ile His Gly Ser Ser Gly Thr Gly Ser 
            660                 665                 670         


Ile Ala Pro Ala Asp Ala Gly Met Ala Leu Val Phe Ala Leu Gln Met 
        675                 680                 685             


Ser Gly Ile Phe Gln Phe Ala Val Arg Thr Gln Thr Glu Leu Glu Ala 
    690                 695                 700                 


Lys Met Thr Cys Val Glu Arg Val Thr Tyr Tyr Ser Asp His Ile Lys 
705                 710                 715                 720 


Ser Glu Asp Gly Trp Asn Asn Gly Ile Gly Asp Ser Ser Arg Asn Asp 
                725                 730                 735     


Ser Phe Pro Asn Gly Cys Ile Val Phe Arg Gly Val Ser Leu Arg Tyr 
            740                 745                 750         


Arg Pro Asp Leu Pro Leu Ala Leu Asp Asp Val Asn Phe Arg Ile Glu 
        755                 760                 765             


Pro Lys Glu Lys Ile Gly Ile Ile Gly Arg Thr Gly Ser Gly Lys Thr 
    770                 775                 780                 


Ser Leu Cys Asn Ala Leu Tyr Arg Leu Tyr Pro Leu Thr Ser Gly Ser 
785                 790                 795                 800 


Ile Glu Ile Asp Gly Ile Asn Ile Ala Cys Ile Gly Leu Tyr Arg Leu 
                805                 810                 815     


Arg Arg Ala Met Ala Val Ile Pro Gln Asp Pro Thr Leu Phe Val Gly 
            820                 825                 830         


Thr Ile Arg Phe Asn Ile Asp Pro Asn Asn Glu Phe Thr Asp Asp Gln 
        835                 840                 845             


Ile Trp Met Ser Leu Glu Lys Thr Tyr Leu Lys Asp Met Val Ser Ser 
    850                 855                 860                 


Leu Asp Arg Lys Leu Asp Ser Pro Val Thr Glu Gly Gly Arg Asn Leu 
865                 870                 875                 880 


Ser Val Gly Glu Arg Gln Leu Phe Cys Met Ala Arg Ala Leu Leu Arg 
                885                 890                 895     


Gln Val Arg Ile Val Val Leu Asp Glu Ala Thr Gly Ser Leu Asp Asn 
            900                 905                 910         


Ala Thr Asp Arg His Ile Gln Lys Cys Leu Arg Glu Ala Phe Val Gly 
        915                 920                 925             


Cys Thr Val Met Ile Ile Ala His Arg Leu Glu Asn Val Leu Gly Leu 
    930                 935                 940                 


Asp Lys Ile Leu His Met Lys Gln Gly Lys Ile Val Lys Tyr Asp Thr 
945                 950                 955                 960 


Ile Gln Asn Leu Ile Arg Asp Gln Asn His Pro Leu Arg Arg Leu Leu 
                965                 970                 975     


Asp Asn Gln Lys Leu Arg Arg Val Ile Arg Thr Gln Lys Glu Gln Ser 
            980                 985                 990         


Thr Lys Lys Asn Leu Glu Gln Ser  Ser Lys Ile Ser Pro  Asn Glu Ser 
        995                 1000                 1005             


Ser Gly  Ser Ser Pro Glu Arg  Ile His Ser Thr Phe  Leu Ala Ser 
    1010                 1015                 1020             


Asp Lys  Thr Ser Pro Glu Thr  Ser Glu Phe Glu Lys  Ile Ser Asp 
    1025                 1030                 1035             


Ser Ile  Asp Lys Glu Ile Thr  Thr Met Ser Asn Asp  Asn Ser Asp 
    1040                 1045                 1050             


Leu Glu  Val Ile Asn Lys Ser  Asp Ala Glu Ser Asn  Cys Gly Ser 
    1055                 1060                 1065             


Ser Gly  Ser Lys Leu Asp Ile  Lys Leu Glu Asp Ile  Ile Asn Glu 
    1070                 1075                 1080             


Lys Ala  Val Glu Glu Glu Thr  Thr Leu Thr Ala Glu  Asp Phe Glu 
    1085                 1090                 1095             


Lys Thr  Ile Asp Glu Glu Phe  Asn Leu Thr Leu Leu  Gly Ile Gln 
    1100                 1105                 1110             


Met Lys  Pro Asp Pro Thr Met  Gly Asn Met Thr Glu  Gly Asp Ile 
    1115                 1120                 1125             


Val Leu  Pro Asn Phe Lys Ala  Phe Ala Asp Tyr Arg  Asn Asn Arg 
    1130                 1135                 1140             


Thr Glu  Arg Ser Ala Ala Arg  His Ile Tyr Arg Arg  Trp Pro Asn 
    1145                 1150                 1155             


Ala Glu  Ile Pro Tyr Ala Leu  Ser Ser Arg Tyr Gly  Ala Tyr Ser 
    1160                 1165                 1170             


Arg Ser  Val Ile Ala Lys Ala  Met Lys Lys Phe His  Asp Ile Ser 
    1175                 1180                 1185             


Cys Val  Arg Phe Val Pro Arg  Val Tyr Asn Gln His  Asp Asp Tyr 
    1190                 1195                 1200             


Ile Tyr  Ile Phe Pro His Asp  Gly Cys Tyr Ser Phe  Val Gly Arg 
    1205                 1210                 1215             


Ser Gly  Gly Arg Gln Pro Val  Ser Leu Glu Ala Asn  Cys Ile Gln 
    1220                 1225                 1230             


Ser Gly  Thr Ile Ile His Glu  Leu Met His Val Val  Gly Phe Phe 
    1235                 1240                 1245             


His Glu  Gln Ser Arg Pro Asp  Arg Asp Glu Tyr Ile  Glu Ile Met 
    1250                 1255                 1260             


Trp Gln  Asn Val Ile Arg Gly  Ser Glu Asn Gln Phe  Asp Lys Gln 
    1265                 1270                 1275             


Ser Leu  Arg Tyr Leu Asp Pro  Leu Asn Glu Ser Tyr  Asp Tyr Ser 
    1280                 1285                 1290             


Ser Ile  Met His Tyr Gly Pro  Tyr Ala Phe Ser Gly  Asn Gly Arg 
    1295                 1300                 1305             


Arg Thr  Ile Ile Ala Leu Lys  Pro Gly Ala Gly Lys  Met Gly Gln 
    1310                 1315                 1320             


Arg Glu  Ser Leu Thr Glu Ile  Asp Ile Arg Lys Ile  Asn Lys Leu 
    1325                 1330                 1335             


Tyr His  Cys Gln Gln Lys Ser  Thr Gln Glu Asn Ser  Ile Glu Asp 
    1340                 1345                 1350             


Asn Val  Glu Ile Thr Lys Ser  Ile Val Pro Leu Lys  Pro Ile Asn 
    1355                 1360                 1365             


Glu Gln  Lys Leu Ile Ser Glu  Glu Asp Leu 
    1370                 1375             


<210>  39
<211>  1932
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reprolysine segment of RMN chimera

<400>  39
catcatgata tctattgccc tttacacatt tactttggtg agcatgaatt ggacgccaat       60

cagctaatca gcatttctca aactattcaa cccaaattcg aactgacact ccagaacgac      120

ttcggcgaga gtagggactt cattttccaa tccaatcgtg aactcagcaa gacatcctcg      180

aagatcgaca tgttgtgcca tttcgaaggt atctcaaaca cgggagaaca cagtgccatg      240

tcaacttgca gtatgtcatt attgggcggc ttgtttacta tcaacggccg tcgattcgtc      300

ttggaagtgg gcctgaatgc cctgtttcac ttcgtccctt tgtctgatca ttcctgtgat      360

tggggattac gtagtaaacg ttccatcgcc ggtagccatg ttgccgagta ctatgcccaa      420

ttcttggatg gtcgatggag gtacgtagag ctggctctga ttgcggataa gctcgtcttt      480

gaaaagtacc acaagaacgt aactgaggtc atgcagcgct tgaatgccat tacaaactac      540

ataaactctc tgtatctccc catcaacatc cgtgttgtgc tcgtctgggc tgacgtctgg      600

accaacgata accctgtcga tattacgtcc aatagcgata ccaccctttg gaacttctta      660

aattggcgta agggcctgct aaaggaccac cctcacgata acgcccatct gctgacagga      720

gtgatcttcg agaataacgt ggtgggaaag gcatttaagg gtaccatgtg ctcttacgac      780

ttcagcggcg gcgttgatat cgagcattcc gatcaagccg cgtatgtggc agcaacgatt      840

gctcacgaaa tgggccacaa cttcggcatg gaacatgaca tcgacgagat tgagtgtcgt      900

tgccctgcga agtcttgcat tatgtcccca gcaacgggta taacacaccc gaccttctgg      960

agcgagtgta gtatgagagc tttgcaacac tctttctctc gcggcgttga ctactgcctg     1020

cgcaacagcc cgacttccgt gttcggagga gctcgctgcg gtaatggtat cgttgaggct     1080

ggagaggaat gcgattgtgg cacaccttcc tcctgcatca acaaatgctg taacccagct     1140

acttgccgtc tgtccgaaac agccgtttgt gctacaggag aatgctgtga cctgaacacc     1200

tgtcagctgc tatcggccac taccgtgtgc aggcaagcta ctaatgagtg cgaccttccc     1260

gagtattgtg acggtctgat ggaacattgc cctgcggact tcttcgtaca agacggtcac     1320

gaatgcccta atcacgttga cgactactgc tacaacggtt attgcggttc cagagatgcg     1380

cagtgtcagc atatctgggg ttcaaccggt cgtaatgctg caccagcctg ttacgacctt     1440

aacttgtctg gaagcagcgg aggaaactgc ggatttctgc acgagactaa tcgcttcgtt     1500

ccatgcaaca agaacgacat caagtgtggt aggctacact gcattcatga gaacgagaaa     1560

ctggttttcg gagatccctc aacggtttac accgcttaca ctggcttgag actgcgtaac     1620

ggtgaggacg tcgcgtgtag ggtcatatgg acaaaatata tctcaggtca gaaggaacct     1680

gaccccggta tggtcccgaa cggtgcggta tgcggccaag acgagatgtg cgtagatgcc     1740

aagtgccaga atagaaccgc taaagtcttg atggctccaa agtgcgaacc ggtatcctgc     1800

aacaacgcag gcatctgtaa caatatgggt aactgtcatt gcgaccccgg ttacggcgga     1860

tcatcatgtg ccattccggg ccctggtggt tccgtaaaca gcggtcccgc tattgaggga     1920

ggagtgatcc ac                                                         1932


<210>  40
<211>  1191
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mrp5 segment of Reprolysin-Mrp5-Nas4 (RMN) chimera

<400>  40
acgggaagta tcgctcccgc tgacgccggc atggccctcg tgtttgctct ccaaatgtct       60

ggaattttcc agttcgcggt ccgcacacag accgaactgg aggctaagat gacatgcgtg      120

gagagggtta cgtactactc agatcacatt aagtcggagg acggctggaa caacggtatt      180

ggtgattctt caaggaatga ctccttcccc aacggttgca tcgtgttcag gggagtgtct      240

ctgcgatacc gcccagactt gcccttagct ttggacgacg tcaacttccg tatagaaccg      300

aaagaaaaaa ttggtatcat aggacgtacg ggtagcggca aaacctcatt gtgtaacgct      360

ctgtatcgcc tctacccttt aacctcggga agcatcgaga tagacggtat taacatagct      420

tgtataggac tgtatcgcct tcgcagagca atggcggtta ttccgcagga ccctacgctc      480

tttgtaggaa ctatccgctt caacatcgac ccaaataatg aattcaccga tgaccaaatc      540

tggatgagct tggaaaagac atacctcaaa gacatggtgt caagtcttga cagaaaactg      600

gatagtcccg tgaccgaggg cggccgtaat ctaagcgtag gcgagagaca gttgttctgt      660

atggcgagag cactcttgcg acaagtcagg atcgtcgtgc tggatgaggc gacgggctcc      720

ttggataatg caactgatcg tcacatccag aagtgtctca gagaagcatt tgtgggttgc      780

acagtgatga ttatcgctca cagacttgag aatgttctag gcctggacaa aatcttgcac      840

atgaaacagg gtaaaatcgt caaatacgat acaatccaga accttatcag ggaccagaat      900

catccactgc gaagattgct cgacaaccag aagcttaggc gtgtgattcg cacgcaaaag      960

gaacagtcga caaagaagaa cctcgaacaa agctctaaga tcagcccaaa tgaatcctcc     1020

ggctctagtc cagagcgcat acattcgact tttcttgctt cggacaagac gagtccagag     1080

acaagcgagt tcgaaaagat atcagactcc atcgataagg agatcaccac tatgtcgaac     1140

gacaactcag atctggaggt gatcaataag agtgacgccg agtccaactg c              1191


<210>  41
<211>  894
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nas4 segment of Reprolysin-Mrp5-Nas4 (RMN) chimera

<400>  41
tcaaagcttg acataaaact tgaggacatt attaacgaaa aggctgtgga ggaagaaacc       60

actctgactg ccgaggattt tgagaaaact attgacgaag agttcaacct cactctcctc      120

ggtatacaaa tgaagccaga cccaaccatg ggtaatatga ctgaaggtga tatcgttctc      180

cccaacttca aggcattcgc agactatcgc aacaacagga ccgagcgtag tgccgcccga      240

cacatttaca ggagatggcc caacgcagag atcccgtacg ccctatcgag tcgctacgga      300

gcttactcta ggtccgtgat agcgaaagcc atgaagaagt tccacgacat ctcatgtgta      360

agatttgtcc caagggtata caaccaacac gatgactata tctacatttt ccctcacgat      420

ggttgctact ctttcgtggg tagatcaggt ggccgccaac ctgtaagcct cgaagctaac      480

tgtatccagt cgggtacaat cattcacgaa ctgatgcacg tcgtcggttt ctttcacgag      540

caatcacgcc cagatcgcga cgaatacatc gaaatcatgt ggcagaatgt tatccgcggt      600

tcggaaaatc agttcgataa gcagtcgctg cgctacctcg atcccctgaa cgaatcttat      660

gattactcct ccattatgca ctacggccct tatgcattct cgggtaacgg acgccgtacc      720

attatcgcgc tcaagcctgg cgctggcaaa atgggtcagc gtgaatcact caccgagatc      780

gacatccgca aaatcaacaa actgtaccac tgccaacaga agtctaccca ggaaaacagc      840

atagaggata acgtggagat cactaaaagc atagtgcccc taaagcccat caac            894


<210>  42
<211>  4134
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RMN Chimera with 5' Murine IgK chain leader and 3' C-myc tag

<400>  42
atggaaaccg acacgctatt actttgggtc ttactgttat gggtcccggg aagtaccgga       60

gatcatcatg atatctattg ccctttacac atttactttg gtgagcatga attggacgcc      120

aatcagctaa tcagcatttc tcaaactatt caacccaaat tcgaactgac actccagaac      180

gacttcggcg agagtaggga cttcattttc caatccaatc gtgaactcag caagacatcc      240

tcgaagatcg acatgttgtg ccatttcgaa ggtatctcaa acacgggaga acacagtgcc      300

atgtcaactt gcagtatgtc attattgggc ggcttgttta ctatcaacgg ccgtcgattc      360

gtcttggaag tgggcctgaa tgccctgttt cacttcgtcc ctttgtctga tcattcctgt      420

gattggggat tacgtagtaa acgttccatc gccggtagcc atgttgccga gtactatgcc      480

caattcttgg atggtcgatg gaggtacgta gagctggctc tgattgcgga taagctcgtc      540

tttgaaaagt accacaagaa cgtaactgag gtcatgcagc gcttgaatgc cattacaaac      600

tacataaact ctctgtatct ccccatcaac atccgtgttg tgctcgtctg ggctgacgtc      660

tggaccaacg ataaccctgt cgatattacg tccaatagcg ataccaccct ttggaacttc      720

ttaaattggc gtaagggcct gctaaaggac caccctcacg ataacgccca tctgctgaca      780

ggagtgatct tcgagaataa cgtggtggga aaggcattta agggtaccat gtgctcttac      840

gacttcagcg gcggcgttga tatcgagcat tccgatcaag ccgcgtatgt ggcagcaacg      900

attgctcacg aaatgggcca caacttcggc atggaacatg acatcgacga gattgagtgt      960

cgttgccctg cgaagtcttg cattatgtcc ccagcaacgg gtataacaca cccgaccttc     1020

tggagcgagt gtagtatgag agctttgcaa cactctttct ctcgcggcgt tgactactgc     1080

ctgcgcaaca gcccgacttc cgtgttcgga ggagctcgct gcggtaatgg tatcgttgag     1140

gctggagagg aatgcgattg tggcacacct tcctcctgca tcaacaaatg ctgtaaccca     1200

gctacttgcc gtctgtccga aacagccgtt tgtgctacag gagaatgctg tgacctgaac     1260

acctgtcagc tgctatcggc cactaccgtg tgcaggcaag ctactaatga gtgcgacctt     1320

cccgagtatt gtgacggtct gatggaacat tgccctgcgg acttcttcgt acaagacggt     1380

cacgaatgcc ctaatcacgt tgacgactac tgctacaacg gttattgcgg ttccagagat     1440

gcgcagtgtc agcatatctg gggttcaacc ggtcgtaatg ctgcaccagc ctgttacgac     1500

cttaacttgt ctggaagcag cggaggaaac tgcggatttc tgcacgagac taatcgcttc     1560

gttccatgca acaagaacga catcaagtgt ggtaggctac actgcattca tgagaacgag     1620

aaactggttt tcggagatcc ctcaacggtt tacaccgctt acactggctt gagactgcgt     1680

aacggtgagg acgtcgcgtg tagggtcata tggacaaaat atatctcagg tcagaaggaa     1740

cctgaccccg gtatggtccc gaacggtgcg gtatgcggcc aagacgagat gtgcgtagat     1800

gccaagtgcc agaatagaac cgctaaagtc ttgatggctc caaagtgcga accggtatcc     1860

tgcaacaacg caggcatctg taacaatatg ggtaactgtc attgcgaccc cggttacggc     1920

ggatcatcat gtgccattcc gggccctggt ggttccgtaa acagcggtcc cgctattgag     1980

ggaggagtga tccacggcag ttctggaacg ggaagtatcg ctcccgctga cgccggcatg     2040

gccctcgtgt ttgctctcca aatgtctgga attttccagt tcgcggtccg cacacagacc     2100

gaactggagg ctaagatgac atgcgtggag agggttacgt actactcaga tcacattaag     2160

tcggaggacg gctggaacaa cggtattggt gattcttcaa ggaatgactc cttccccaac     2220

ggttgcatcg tgttcagggg agtgtctctg cgataccgcc cagacttgcc cttagctttg     2280

gacgacgtca acttccgtat agaaccgaaa gaaaaaattg gtatcatagg acgtacgggt     2340

agcggcaaaa cctcattgtg taacgctctg tatcgcctct accctttaac ctcgggaagc     2400

atcgagatag acggtattaa catagcttgt ataggactgt atcgccttcg cagagcaatg     2460

gcggttattc cgcaggaccc tacgctcttt gtaggaacta tccgcttcaa catcgaccca     2520

aataatgaat tcaccgatga ccaaatctgg atgagcttgg aaaagacata cctcaaagac     2580

atggtgtcaa gtcttgacag aaaactggat agtcccgtga ccgagggcgg ccgtaatcta     2640

agcgtaggcg agagacagtt gttctgtatg gcgagagcac tcttgcgaca agtcaggatc     2700

gtcgtgctgg atgaggcgac gggctccttg gataatgcaa ctgatcgtca catccagaag     2760

tgtctcagag aagcatttgt gggttgcaca gtgatgatta tcgctcacag acttgagaat     2820

gttctaggcc tggacaaaat cttgcacatg aaacagggta aaatcgtcaa atacgataca     2880

atccagaacc ttatcaggga ccagaatcat ccactgcgaa gattgctcga caaccagaag     2940

cttaggcgtg tgattcgcac gcaaaaggaa cagtcgacaa agaagaacct cgaacaaagc     3000

tctaagatca gcccaaatga atcctccggc tctagtccag agcgcataca ttcgactttt     3060

cttgcttcgg acaagacgag tccagagaca agcgagttcg aaaagatatc agactccatc     3120

gataaggaga tcaccactat gtcgaacgac aactcagatc tggaggtgat caataagagt     3180

gacgccgagt ccaactgcgg ctcgtctgga tcaaagcttg acataaaact tgaggacatt     3240

attaacgaaa aggctgtgga ggaagaaacc actctgactg ccgaggattt tgagaaaact     3300

attgacgaag agttcaacct cactctcctc ggtatacaaa tgaagccaga cccaaccatg     3360

ggtaatatga ctgaaggtga tatcgttctc cccaacttca aggcattcgc agactatcgc     3420

aacaacagga ccgagcgtag tgccgcccga cacatttaca ggagatggcc caacgcagag     3480

atcccgtacg ccctatcgag tcgctacgga gcttactcta ggtccgtgat agcgaaagcc     3540

atgaagaagt tccacgacat ctcatgtgta agatttgtcc caagggtata caaccaacac     3600

gatgactata tctacatttt ccctcacgat ggttgctact ctttcgtggg tagatcaggt     3660

ggccgccaac ctgtaagcct cgaagctaac tgtatccagt cgggtacaat cattcacgaa     3720

ctgatgcacg tcgtcggttt ctttcacgag caatcacgcc cagatcgcga cgaatacatc     3780

gaaatcatgt ggcagaatgt tatccgcggt tcggaaaatc agttcgataa gcagtcgctg     3840

cgctacctcg atcccctgaa cgaatcttat gattactcct ccattatgca ctacggccct     3900

tatgcattct cgggtaacgg acgccgtacc attatcgcgc tcaagcctgg cgctggcaaa     3960

atgggtcagc gtgaatcact caccgagatc gacatccgca aaatcaacaa actgtaccac     4020

tgccaacaga agtctaccca ggaaaacagc atagaggata acgtggagat cactaaaagc     4080

atagtgcccc taaagcccat caacgagcag aagcttatct ctgaggagga ctta           4134


<210>  43
<211>  95
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fat3 segment of Fat3-Enolase-DiTG-Tropomyosin (FEDT) chimera

<400>  43

Cys Trp Gln Gln Phe Gly Trp Leu Thr His Asp Phe Cys His Gln Gln 
1               5                   10                  15      


Pro Ser Lys Asn Arg Glu Lys Asn Asp Phe Tyr Ser Leu Ile Phe Gly 
            20                  25                  30          


Asn Ile Val Gln Gly Phe Ser Arg Asp Trp Trp Lys Glu Lys His Asn 
        35                  40                  45              


Thr His His Ala Ala Thr Asn Ile Val Gly Gln Asp Gly Asp Ile Asp 
    50                  55                  60                  


Leu Ala Pro Leu Leu Ala Phe Val Pro Asp Asp Leu Lys Lys Tyr Lys 
65                  70                  75                  80  


Ala Leu Phe Glu Gln Phe Ile Ser Lys Ile Ile Pro Tyr Gln His 
                85                  90                  95  


<210>  44
<211>  435
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Enolase segment of Fat3 FEDT chimera

<400>  44

Pro Ile Thr Arg Val His Ala Arg Pro Ile Tyr Asp Ser Arg Gly Asn 
1               5                   10                  15      


Pro Thr Val Glu Val Asp Leu Thr Thr Glu Lys Gly Ile Phe Arg Ala 
            20                  25                  30          


Ala Val Pro Ser Gly Ala Ser Thr Gly Val His Glu Ala Leu Glu Leu 
        35                  40                  45              


Arg Asp Asn Asp Lys Ala Val Asn His Gly Lys Gly Val Leu Gln Ala 
    50                  55                  60                  


Val Arg Asn Val Asn Glu His Ile Gly Pro Ala Leu Val Ala Lys Asn 
65                  70                  75                  80  


Phe Cys Pro Thr Gln Gln Arg Glu Ile Asp His Phe Met Leu Glu Leu 
                85                  90                  95      


Asp Gly Thr Glu Asn Lys Ala Lys Leu Gly Ala Asn Ala Ile Leu Gly 
            100                 105                 110         


Val Ser Leu Ala Val Cys Lys Ala Gly Ala Val His Lys Gly Val Pro 
        115                 120                 125             


Leu Tyr Lys Tyr Ile Ala Glu Leu Ala Gly Thr Gly Gln Val Val Leu 
    130                 135                 140                 


Pro Val Pro Ala Met Asn Val Ile Asn Gly Gly Ser His Ala Gly Asn 
145                 150                 155                 160 


Lys Leu Ala Met Gln Glu Phe Met Ile Met Pro Ile Gly Ala Ser Ser 
                165                 170                 175     


Phe Ser Glu Ala Met Arg Met Gly Ser Glu Ile Tyr His Tyr Leu Lys 
            180                 185                 190         


Ala Glu Ile Lys Lys Arg Tyr Gly Leu Asp Ala Thr Ala Val Gly Asp 
        195                 200                 205             


Glu Gly Gly Phe Ala Pro Asn Ile Gln Asp Asn Arg Glu Gly Leu Asp 
    210                 215                 220                 


Leu Leu Asn Thr Ala Ile Ala Thr Ala Gly Tyr Thr Gly Lys Val Ala 
225                 230                 235                 240 


Ile Ala Met Asp Cys Ala Ala Ser Glu Tyr Tyr Lys Glu Ser Asp Lys 
                245                 250                 255     


Leu Tyr Asp Leu Asp Phe Lys Asn Pro Asn Ser Asp Lys Thr Gln Trp 
            260                 265                 270         


Lys Thr Gly Asp Gln Met Met Glu Ile Tyr Gln Ser Phe Ile Lys Glu 
        275                 280                 285             


Tyr Pro Val Val Ser Ile Glu Asp Trp Phe Asp Gln Asp Asp Trp Asp 
    290                 295                 300                 


Asn Trp Thr Lys Ala Leu Ala Asn Thr His Ile Gln Ile Val Gly Asp 
305                 310                 315                 320 


Asp Leu Thr Val Thr Asn Pro Lys Arg Ile Ala Leu Ala Ala Glu Lys 
                325                 330                 335     


Lys Ala Cys Asn Cys Leu Leu Leu Lys Val Asn Gln Ile Gly Ser Val 
            340                 345                 350         


Thr Glu Ser Ile Asp Ala Ala Asn Leu Ala Arg Lys Asn Gly Trp Gly 
        355                 360                 365             


Val Met Val Ser His Arg Ser Gly Glu Thr Glu Asp Thr Phe Ile Ala 
    370                 375                 380                 


Asp Leu Val Val Gly Leu Ala Thr Gly Gln Ile Lys Thr Gly Ala Pro 
385                 390                 395                 400 


Cys Arg Ser Glu Arg Leu Ala Lys Tyr Asn Gln Ile Leu Arg Ile Glu 
                405                 410                 415     


Glu Glu Leu Gly Ser Ala Ala Ile Tyr Ala Gly Gln Lys Phe Arg Asn 
            420                 425                 430         


Pro Gln Ala 
        435 


<210>  45
<211>  467
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DiTG segment of FEDT chimera

<400>  45

Lys Phe Thr Asp Ala Asp Phe Lys Glu Gly Ile Lys Pro Tyr Asp Val 
1               5                   10                  15      


Leu Leu Val Lys Phe Tyr Ala Pro Trp Cys Gly His Cys Lys Lys Ile 
            20                  25                  30          


Ala Pro Glu Phe Glu Lys Ala Ala Thr Lys Leu Leu Gln Asn Asp Pro 
        35                  40                  45              


Pro Ile His Leu Ala Glu Val Asp Cys Thr Glu Glu Lys Lys Thr Cys 
    50                  55                  60                  


Asp Glu Tyr Gly Val Ser Gly Phe Pro Thr Leu Lys Ile Phe Arg Lys 
65                  70                  75                  80  


Gly Glu Leu Ala Gln Asp Tyr Asp Gly Pro Arg Val Ala Glu Gly Ile 
                85                  90                  95      


Val Lys Tyr Met Arg Gly Gln Ala Gly Pro Ser Ala Thr Glu Ile Asn 
            100                 105                 110         


Thr Gln Gln Glu Phe Glu Lys Met Leu Gln Ala Asp Asp Val Thr Ile 
        115                 120                 125             


Cys Gly Phe Phe Glu Glu Asn Ser Lys Leu Lys Asp Ser Phe Leu Lys 
    130                 135                 140                 


Val Ala Asp Thr Glu Arg Asp Arg Phe Lys Phe Val Trp Thr Ser Asn 
145                 150                 155                 160 


Lys Gln Ile Leu Glu Ser Arg Gly Tyr Asn Asp Asp Ile Val Ala Tyr 
                165                 170                 175     


Gln Pro Lys Lys Phe His Asn Lys Phe Glu Pro Asn Glu Phe Lys Tyr 
            180                 185                 190         


Asp Gly Asn Tyr Asp Thr Asp Lys Ile Lys Glu Phe Leu Leu His Glu 
        195                 200                 205             


Thr Asn Gly Leu Val Gly Ile Arg Thr Ala Glu Asn Arg Tyr Gln Tyr 
    210                 215                 220                 


Asp Leu Leu Pro Met Phe Val Val Tyr Gly Lys Val Asp Tyr Glu Leu 
225                 230                 235                 240 


Asp Pro Lys Gly Ser Asn Tyr Trp Arg Asn Arg Val Leu Met Val Ala 
                245                 250                 255     


Lys Asp Tyr Lys Arg Lys Ala Asn Phe Ala Met Ser Asn Lys Glu Asp 
            260                 265                 270         


Phe Ser Phe Asp Leu Asp Glu Phe Gly Leu Ala Asn Arg Lys Asp Thr 
        275                 280                 285             


Lys Pro Leu Val Ala Ala Arg Ser Lys Lys Gly Lys Phe Phe Met Lys 
    290                 295                 300                 


Glu Glu Phe Ser Phe Ser Val Glu Asn Leu Lys Lys Phe Val Glu Asp 
305                 310                 315                 320 


Val Ile Gly Asp Arg Leu Glu Pro Tyr Met Lys Ser Glu Glu Ala Pro 
                325                 330                 335     


Glu Asp Gln Gly Asp Val Lys Val Val Val Ala Lys Thr Phe Gln Glu 
            340                 345                 350         


Met Ile Met Asn Val Glu Lys Asp Val Leu Ile Glu Phe Tyr Ala Pro 
        355                 360                 365             


Trp Cys Gly His Cys Lys Ala Leu Ala Pro Lys Tyr Asp Glu Leu Gly 
    370                 375                 380                 


Gln Lys Leu Ser Gly Glu Pro Gly Val Val Ile Ala Lys Met Asp Ala 
385                 390                 395                 400 


Thr Ala Asn Asp Val Pro Pro Pro Phe Gln Val Gln Gly Phe Pro Thr 
                405                 410                 415     


Leu Tyr Trp Val Pro Lys Asn Lys Lys Asp Lys Pro Glu Pro Tyr Ser 
            420                 425                 430         


Gly Gly Arg Glu Val Asp Asp Phe Ile Lys Tyr Ile Ala Lys His Ala 
        435                 440                 445             


Thr Glu Glu Leu Lys Gly Tyr Lys Arg Asp Gly Lys Pro Lys Lys Lys 
    450                 455                 460                 


Glu Glu Leu 
465         


<210>  46
<211>  253
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Tropomyosin segment of FEDT chimera

<400>  46

Thr Asp Lys Leu Glu Arg Ile Glu Glu Glu Leu Arg Asp Thr Gln Lys 
1               5                   10                  15      


Lys Met Met Gln Thr Glu Asn Asp Leu Asp Lys Ala Gln Glu Asp Leu 
            20                  25                  30          


Ala Val Ala Asn Thr Asn Leu Glu Glu Lys Glu Lys Lys Val Gln Glu 
        35                  40                  45              


Ala Glu Ala Glu Val Ala Ala Leu Asn Arg Arg Met Thr Leu Leu Glu 
    50                  55                  60                  


Glu Glu Leu Glu Arg Ala Glu Glu Arg Leu Lys Ile Ala Thr Asp Lys 
65                  70                  75                  80  


Leu Glu Glu Ala Thr His Thr Ala Asp Glu Ser Glu Arg Val Arg Lys 
                85                  90                  95      


Val Met Glu Asn Arg Ser Phe Gln Asp Glu Glu Arg Ala Asn Thr Val 
            100                 105                 110         


Glu Ser Gln Leu Lys Glu Ala Gln Leu Leu Ala Glu Glu Ala Asp Arg 
        115                 120                 125             


Lys Tyr Asp Glu Val Ala Arg Lys Leu Ala Met Val Glu Ala Asp Leu 
    130                 135                 140                 


Glu Arg Ala Glu Glu Arg Ala Glu Ala Gly Glu Asn Lys Ile Val Glu 
145                 150                 155                 160 


Leu Glu Glu Glu Leu Arg Val Val Gly Asn Asn Leu Lys Ser Leu Glu 
                165                 170                 175     


Val Ser Glu Glu Lys Ala Leu Gln Arg Glu Asp Ser Tyr Glu Glu Gln 
            180                 185                 190         


Ile Arg Thr Val Ser Ala Arg Leu Lys Glu Ala Glu Thr Arg Ala Glu 
        195                 200                 205             


Phe Ala Glu Arg Ser Val Gln Lys Leu Gln Lys Glu Val Asp Arg Leu 
    210                 215                 220                 


Glu Asp Glu Leu Val His Glu Lys Glu Arg Tyr Lys Asn Ile Ser Glu 
225                 230                 235                 240 


Glu Leu Asp Gln Thr Phe Gln Glu Leu Ser Gly Tyr Glu 
                245                 250             


<210>  47
<211>  1292
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FEDT Chimera with 5' Murine IgK chain leader and 3' C-myc tag

<400>  47

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Cys Trp Gln Gln Phe Gly Trp Leu Thr His Asp 
            20                  25                  30          


Phe Cys His Gln Gln Pro Ser Lys Asn Arg Glu Lys Asn Asp Phe Tyr 
        35                  40                  45              


Ser Leu Ile Phe Gly Asn Ile Val Gln Gly Phe Ser Arg Asp Trp Trp 
    50                  55                  60                  


Lys Glu Lys His Asn Thr His His Ala Ala Thr Asn Ile Val Gly Gln 
65                  70                  75                  80  


Asp Gly Asp Ile Asp Leu Ala Pro Leu Leu Ala Phe Val Pro Asp Asp 
                85                  90                  95      


Leu Lys Lys Tyr Lys Ala Leu Phe Glu Gln Phe Ile Ser Lys Ile Ile 
            100                 105                 110         


Pro Tyr Gln His Gly Ser Ser Gly Pro Ile Thr Arg Val His Ala Arg 
        115                 120                 125             


Pro Ile Tyr Asp Ser Arg Gly Asn Pro Thr Val Glu Val Asp Leu Thr 
    130                 135                 140                 


Thr Glu Lys Gly Ile Phe Arg Ala Ala Val Pro Ser Gly Ala Ser Thr 
145                 150                 155                 160 


Gly Val His Glu Ala Leu Glu Leu Arg Asp Asn Asp Lys Ala Val Asn 
                165                 170                 175     


His Gly Lys Gly Val Leu Gln Ala Val Arg Asn Val Asn Glu His Ile 
            180                 185                 190         


Gly Pro Ala Leu Val Ala Lys Asn Phe Cys Pro Thr Gln Gln Arg Glu 
        195                 200                 205             


Ile Asp His Phe Met Leu Glu Leu Asp Gly Thr Glu Asn Lys Ala Lys 
    210                 215                 220                 


Leu Gly Ala Asn Ala Ile Leu Gly Val Ser Leu Ala Val Cys Lys Ala 
225                 230                 235                 240 


Gly Ala Val His Lys Gly Val Pro Leu Tyr Lys Tyr Ile Ala Glu Leu 
                245                 250                 255     


Ala Gly Thr Gly Gln Val Val Leu Pro Val Pro Ala Met Asn Val Ile 
            260                 265                 270         


Asn Gly Gly Ser His Ala Gly Asn Lys Leu Ala Met Gln Glu Phe Met 
        275                 280                 285             


Ile Met Pro Ile Gly Ala Ser Ser Phe Ser Glu Ala Met Arg Met Gly 
    290                 295                 300                 


Ser Glu Ile Tyr His Tyr Leu Lys Ala Glu Ile Lys Lys Arg Tyr Gly 
305                 310                 315                 320 


Leu Asp Ala Thr Ala Val Gly Asp Glu Gly Gly Phe Ala Pro Asn Ile 
                325                 330                 335     


Gln Asp Asn Arg Glu Gly Leu Asp Leu Leu Asn Thr Ala Ile Ala Thr 
            340                 345                 350         


Ala Gly Tyr Thr Gly Lys Val Ala Ile Ala Met Asp Cys Ala Ala Ser 
        355                 360                 365             


Glu Tyr Tyr Lys Glu Ser Asp Lys Leu Tyr Asp Leu Asp Phe Lys Asn 
    370                 375                 380                 


Pro Asn Ser Asp Lys Thr Gln Trp Lys Thr Gly Asp Gln Met Met Glu 
385                 390                 395                 400 


Ile Tyr Gln Ser Phe Ile Lys Glu Tyr Pro Val Val Ser Ile Glu Asp 
                405                 410                 415     


Trp Phe Asp Gln Asp Asp Trp Asp Asn Trp Thr Lys Ala Leu Ala Asn 
            420                 425                 430         


Thr His Ile Gln Ile Val Gly Asp Asp Leu Thr Val Thr Asn Pro Lys 
        435                 440                 445             


Arg Ile Ala Leu Ala Ala Glu Lys Lys Ala Cys Asn Cys Leu Leu Leu 
    450                 455                 460                 


Lys Val Asn Gln Ile Gly Ser Val Thr Glu Ser Ile Asp Ala Ala Asn 
465                 470                 475                 480 


Leu Ala Arg Lys Asn Gly Trp Gly Val Met Val Ser His Arg Ser Gly 
                485                 490                 495     


Glu Thr Glu Asp Thr Phe Ile Ala Asp Leu Val Val Gly Leu Ala Thr 
            500                 505                 510         


Gly Gln Ile Lys Thr Gly Ala Pro Cys Arg Ser Glu Arg Leu Ala Lys 
        515                 520                 525             


Tyr Asn Gln Ile Leu Arg Ile Glu Glu Glu Leu Gly Ser Ala Ala Ile 
    530                 535                 540                 


Tyr Ala Gly Gln Lys Phe Arg Asn Pro Gln Ala Gly Ser Ser Gly Lys 
545                 550                 555                 560 


Phe Thr Asp Ala Asp Phe Lys Glu Gly Ile Lys Pro Tyr Asp Val Leu 
                565                 570                 575     


Leu Val Lys Phe Tyr Ala Pro Trp Cys Gly His Cys Lys Lys Ile Ala 
            580                 585                 590         


Pro Glu Phe Glu Lys Ala Ala Thr Lys Leu Leu Gln Asn Asp Pro Pro 
        595                 600                 605             


Ile His Leu Ala Glu Val Asp Cys Thr Glu Glu Lys Lys Thr Cys Asp 
    610                 615                 620                 


Glu Tyr Gly Val Ser Gly Phe Pro Thr Leu Lys Ile Phe Arg Lys Gly 
625                 630                 635                 640 


Glu Leu Ala Gln Asp Tyr Asp Gly Pro Arg Val Ala Glu Gly Ile Val 
                645                 650                 655     


Lys Tyr Met Arg Gly Gln Ala Gly Pro Ser Ala Thr Glu Ile Asn Thr 
            660                 665                 670         


Gln Gln Glu Phe Glu Lys Met Leu Gln Ala Asp Asp Val Thr Ile Cys 
        675                 680                 685             


Gly Phe Phe Glu Glu Asn Ser Lys Leu Lys Asp Ser Phe Leu Lys Val 
    690                 695                 700                 


Ala Asp Thr Glu Arg Asp Arg Phe Lys Phe Val Trp Thr Ser Asn Lys 
705                 710                 715                 720 


Gln Ile Leu Glu Ser Arg Gly Tyr Asn Asp Asp Ile Val Ala Tyr Gln 
                725                 730                 735     


Pro Lys Lys Phe His Asn Lys Phe Glu Pro Asn Glu Phe Lys Tyr Asp 
            740                 745                 750         


Gly Asn Tyr Asp Thr Asp Lys Ile Lys Glu Phe Leu Leu His Glu Thr 
        755                 760                 765             


Asn Gly Leu Val Gly Ile Arg Thr Ala Glu Asn Arg Tyr Gln Tyr Asp 
    770                 775                 780                 


Leu Leu Pro Met Phe Val Val Tyr Gly Lys Val Asp Tyr Glu Leu Asp 
785                 790                 795                 800 


Pro Lys Gly Ser Asn Tyr Trp Arg Asn Arg Val Leu Met Val Ala Lys 
                805                 810                 815     


Asp Tyr Lys Arg Lys Ala Asn Phe Ala Met Ser Asn Lys Glu Asp Phe 
            820                 825                 830         


Ser Phe Asp Leu Asp Glu Phe Gly Leu Ala Asn Arg Lys Asp Thr Lys 
        835                 840                 845             


Pro Leu Val Ala Ala Arg Ser Lys Lys Gly Lys Phe Phe Met Lys Glu 
    850                 855                 860                 


Glu Phe Ser Phe Ser Val Glu Asn Leu Lys Lys Phe Val Glu Asp Val 
865                 870                 875                 880 


Ile Gly Asp Arg Leu Glu Pro Tyr Met Lys Ser Glu Glu Ala Pro Glu 
                885                 890                 895     


Asp Gln Gly Asp Val Lys Val Val Val Ala Lys Thr Phe Gln Glu Met 
            900                 905                 910         


Ile Met Asn Val Glu Lys Asp Val Leu Ile Glu Phe Tyr Ala Pro Trp 
        915                 920                 925             


Cys Gly His Cys Lys Ala Leu Ala Pro Lys Tyr Asp Glu Leu Gly Gln 
    930                 935                 940                 


Lys Leu Ser Gly Glu Pro Gly Val Val Ile Ala Lys Met Asp Ala Thr 
945                 950                 955                 960 


Ala Asn Asp Val Pro Pro Pro Phe Gln Val Gln Gly Phe Pro Thr Leu 
                965                 970                 975     


Tyr Trp Val Pro Lys Asn Lys Lys Asp Lys Pro Glu Pro Tyr Ser Gly 
            980                 985                 990         


Gly Arg Glu Val Asp Asp Phe Ile  Lys Tyr Ile Ala Lys  His Ala Thr 
        995                 1000                 1005             


Glu Glu  Leu Lys Gly Tyr Lys  Arg Asp Gly Lys Pro  Lys Lys Lys 
    1010                 1015                 1020             


Glu Glu  Leu Gly Ser Ser Gly  Thr Asp Lys Leu Glu  Arg Ile Glu 
    1025                 1030                 1035             


Glu Glu  Leu Arg Asp Thr Gln  Lys Lys Met Met Gln  Thr Glu Asn 
    1040                 1045                 1050             


Asp Leu  Asp Lys Ala Gln Glu  Asp Leu Ala Val Ala  Asn Thr Asn 
    1055                 1060                 1065             


Leu Glu  Glu Lys Glu Lys Lys  Val Gln Glu Ala Glu  Ala Glu Val 
    1070                 1075                 1080             


Ala Ala  Leu Asn Arg Arg Met  Thr Leu Leu Glu Glu  Glu Leu Glu 
    1085                 1090                 1095             


Arg Ala  Glu Glu Arg Leu Lys  Ile Ala Thr Asp Lys  Leu Glu Glu 
    1100                 1105                 1110             


Ala Thr  His Thr Ala Asp Glu  Ser Glu Arg Val Arg  Lys Val Met 
    1115                 1120                 1125             


Glu Asn  Arg Ser Phe Gln Asp  Glu Glu Arg Ala Asn  Thr Val Glu 
    1130                 1135                 1140             


Ser Gln  Leu Lys Glu Ala Gln  Leu Leu Ala Glu Glu  Ala Asp Arg 
    1145                 1150                 1155             


Lys Tyr  Asp Glu Val Ala Arg  Lys Leu Ala Met Val  Glu Ala Asp 
    1160                 1165                 1170             


Leu Glu  Arg Ala Glu Glu Arg  Ala Glu Ala Gly Glu  Asn Lys Ile 
    1175                 1180                 1185             


Val Glu  Leu Glu Glu Glu Leu  Arg Val Val Gly Asn  Asn Leu Lys 
    1190                 1195                 1200             


Ser Leu  Glu Val Ser Glu Glu  Lys Ala Leu Gln Arg  Glu Asp Ser 
    1205                 1210                 1215             


Tyr Glu  Glu Gln Ile Arg Thr  Val Ser Ala Arg Leu  Lys Glu Ala 
    1220                 1225                 1230             


Glu Thr  Arg Ala Glu Phe Ala  Glu Arg Ser Val Gln  Lys Leu Gln 
    1235                 1240                 1245             


Lys Glu  Val Asp Arg Leu Glu  Asp Glu Leu Val His  Glu Lys Glu 
    1250                 1255                 1260             


Arg Tyr  Lys Asn Ile Ser Glu  Glu Leu Asp Gln Thr  Phe Gln Glu 
    1265                 1270                 1275             


Leu Ser  Gly Tyr Glu Gln Lys  Leu Ile Ser Glu Glu  Asp Leu 
    1280                 1285                 1290         


<210>  48
<211>  285
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Fat3 segment of Fat3-Enolase-DiTG-Tropomyosin (FEDT) chimera

<400>  48
tgctggcaac aatttggatg gttaactcat gacttctgcc atcagcaacc ctcaaagaat       60

cgtgagaaga atgatttcta ctctctaatc tttggcaata ttgtgcaggg cttcagtcga      120

gattggtgga aggagaaaca caacacgcac catgccgcta cgaacattgt aggccaagac      180

ggtgatattg atttggctcc attgctggca ttcgttcctg acgatctcaa gaagtacaaa      240

gcccttttcg aacagttcat ctccaagata atcccctacc agcac                      285


<210>  49
<211>  1305
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Enolase segment of Fat3 FEDT chimera

<400>  49
ccaattacgc gtgttcatgc tcgtcccatt tacgactcca ggggtaatcc taccgtcgag       60

gtcgacttga cgacggagaa gggaatcttc agagccgccg tgccctcggg agcttcgact      120

ggtgtacacg aagctcttga gctcagggac aacgataagg cggtaaatca cggaaaaggt      180

gtgctgcagg cagtcagaaa cgtgaacgag cacatcggac ccgctttggt ggccaagaac      240

ttctgcccta cccaacagcg cgaaatcgac cactttatgc tggaactgga cggtacagaa      300

aacaaggcca agttaggagc caatgccatt ttgggcgtgt cgctggcggt ctgtaaggcc      360

ggcgctgttc acaaaggcgt gcctctgtac aagtacatcg ccgaattagc gggtactggc      420

caagtcgtac tgcccgttcc ggctatgaac gtcatcaacg gaggtagcca tgcgggaaac      480

aaattggcga tgcaggagtt catgatcatg ccgatcggtg cctcgtcctt cagcgaagcc      540

atgcgtatgg gtagcgagat ctaccactac ttgaaggccg aaattaagaa gcgttatgga      600

ctcgacgcta ccgccgtggg tgacgaaggt ggttttgcac cgaacatcca ggacaacaga      660

gaaggtctgg acttgttgaa cactgccata gccactgcgg gatacactgg caaggtagct      720

atagccatgg actgcgcagc atcagagtat tacaaggagt ctgataaact gtacgacctt      780

gacttcaaga atcccaattc cgataagaca cagtggaaaa caggtgatca gatgatggag      840

atttaccagt catttatcaa ggaatacccc gtcgtcagca tagaggattg gttcgaccaa      900

gatgactggg acaattggac aaaagcactg gctaacactc atatccagat cgtgggtgat      960

gacctcactg ttacgaaccc aaagaggatt gctctagcgg cagaaaagaa ggcatgcaac     1020

tgcttgttgc taaaagtgaa ccaaatcgga tcagtcaccg agagcattga tgctgccaat     1080

ctggctcgca agaatggctg gggcgtcatg gtgtctcatc gctctggtga gacagaggac     1140

acattcatcg ctgatctagt tgtgggtttg gctactggac agatcaaaac aggagctcct     1200

tgccgttccg agcgcctagc gaaatacaat cagatcctgc gaattgagga agaattaggt     1260

tcagcagcga tttatgctgg tcaaaagttt cgcaacccgc aagct                     1305


<210>  50
<211>  1401
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DiTG segment of FEDT chimera

<400>  50
aaatttactg acgctgactt caaagagggc ataaagccgt atgacgtgct gttggtaaag       60

ttttatgcgc catggtgtgg tcactgcaaa aagatcgcgc ctgagttcga gaaggccgcg      120

acaaaactct tacagaatga ccctccaatc cacttggctg aggtcgactg taccgaagag      180

aagaagacgt gcgatgaata cggtgtctct ggctttccca cgttgaagat tttccgtaag      240

ggcgaactcg cgcaggacta tgacggccca agggtagctg aaggcattgt gaagtatatg      300

cgcggccaag ccggaccgag tgcaaccgaa atcaatacac agcaagaatt cgaaaagatg      360

ctgcaggccg acgacgtgac tatatgtggt ttcttcgagg agaatagtaa gctcaaagac      420

tcctttctta aggtggcgga caccgagagg gacaggttca aattcgtgtg gacctcaaac      480

aaacagatac tcgagtcccg tggatataac gacgacatcg ttgcatacca accgaagaag      540

ttccataaca agttcgaacc taacgaattc aagtacgacg gtaactacga taccgacaag      600

atcaaagagt tcctgttgca cgaaaccaat ggactcgttg gaatccgtac cgccgaaaat      660

agataccagt acgacctact gccgatgttc gtggtatacg gaaaagtcga ctatgagctc      720

gatcctaagg gatctaacta ttggagaaac cgagtactta tggttgccaa ggattacaaa      780

cgcaaagcta acttcgctat gagcaacaaa gaggacttct cgtttgactt agacgaattc      840

ggtctagcga accgcaaaga caccaagcca ttagtcgctg cacgaagcaa gaaaggcaag      900

ttcttcatga aggaggagtt ctccttcagt gttgagaatc tcaagaaatt cgtcgaggac      960

gttatcggag atagactgga gccttacatg aaatccgagg aagccccaga agatcagggc     1020

gatgtcaaag tcgtagtagc aaagacattt caggagatga ttatgaacgt tgagaaggat     1080

gttcttatcg aattctacgc tccctggtgt ggccactgta aggctctggc ccctaaatac     1140

gacgagctcg gtcagaagtt gagtggtgag cctggagtgg tgatagctaa gatggacgca     1200

accgccaacg acgtgcctcc accattccag gtgcaaggtt ttccaacgct atactgggtc     1260

ccaaagaaca agaaagataa gcccgagcca tattcaggtg gaagggaggt cgacgacttc     1320

atcaaataca tcgcgaaaca cgctaccgaa gagctgaagg gttataaaag agatggcaaa     1380

cccaagaaga aagaggagct g                                               1401


<210>  51
<211>  756
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Tropomyosin segment of FEDT chimera

<400>  51
actgacaaac ttgaacgcat cgaggaagaa cttcgcgaca cacagaagaa gatgatgcaa       60

actgagaacg atctcgataa ggcccaagag gatctcgctg tcgctaacac aaacttggaa      120

gaaaaggaga agaaggtgca agaggctgaa gctgaagtgg ctgcactcaa cagacgcatg      180

acgttactcg aggaagagct ggagagggct gaggagcgcc taaagatagc caccgataaa      240

ctcgaggagg caacccatac tgctgatgaa agcgaaagag tccgcaaagt catggagaat      300

cgttccttcc aagatgaaga acgcgcaaac accgtggaaa gccaactgaa agaagcacag      360

ttgctggcag aggaagccga taggaaatat gatgaagttg cgagaaagct ggccatggtt      420

gaggctgatt tagaacgcgc ggaagaacgc gccgaagccg gtgaaaacaa aattgtcgag      480

ctcgaagagg agctgagagt cgtgggcaac aacttgaagt ctctggaggt atcggaggag      540

aaggccctgc agagggaaga ttcctacgag gaacaaattc gtaccgtttc agcacgactt      600

aaggaggcgg aaacacgcgc tgaattcgct gaaaggagtg tgcaaaagct ccagaaagag      660

gtagaccgtc tggaggacga actggtgcac gaaaaggagc gttacaagaa catctcggag      720

gaattagacc aaacctttca ggagctctca ggctac                                756


<210>  52
<211>  3876
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FEDT Chimera with 5' Murine IgK chain leader and 3' C-myc tag

<400>  52
atggagactg acactctttt gctgtgggta cttctcctct gggttcccgg cagcacaggt       60

gattgctggc aacaatttgg atggttaact catgacttct gccatcagca accctcaaag      120

aatcgtgaga agaatgattt ctactctcta atctttggca atattgtgca gggcttcagt      180

cgagattggt ggaaggagaa acacaacacg caccatgccg ctacgaacat tgtaggccaa      240

gacggtgata ttgatttggc tccattgctg gcattcgttc ctgacgatct caagaagtac      300

aaagcccttt tcgaacagtt catctccaag ataatcccct accagcacgg ttcctctggc      360

ccaattacgc gtgttcatgc tcgtcccatt tacgactcca ggggtaatcc taccgtcgag      420

gtcgacttga cgacggagaa gggaatcttc agagccgccg tgccctcggg agcttcgact      480

ggtgtacacg aagctcttga gctcagggac aacgataagg cggtaaatca cggaaaaggt      540

gtgctgcagg cagtcagaaa cgtgaacgag cacatcggac ccgctttggt ggccaagaac      600

ttctgcccta cccaacagcg cgaaatcgac cactttatgc tggaactgga cggtacagaa      660

aacaaggcca agttaggagc caatgccatt ttgggcgtgt cgctggcggt ctgtaaggcc      720

ggcgctgttc acaaaggcgt gcctctgtac aagtacatcg ccgaattagc gggtactggc      780

caagtcgtac tgcccgttcc ggctatgaac gtcatcaacg gaggtagcca tgcgggaaac      840

aaattggcga tgcaggagtt catgatcatg ccgatcggtg cctcgtcctt cagcgaagcc      900

atgcgtatgg gtagcgagat ctaccactac ttgaaggccg aaattaagaa gcgttatgga      960

ctcgacgcta ccgccgtggg tgacgaaggt ggttttgcac cgaacatcca ggacaacaga     1020

gaaggtctgg acttgttgaa cactgccata gccactgcgg gatacactgg caaggtagct     1080

atagccatgg actgcgcagc atcagagtat tacaaggagt ctgataaact gtacgacctt     1140

gacttcaaga atcccaattc cgataagaca cagtggaaaa caggtgatca gatgatggag     1200

atttaccagt catttatcaa ggaatacccc gtcgtcagca tagaggattg gttcgaccaa     1260

gatgactggg acaattggac aaaagcactg gctaacactc atatccagat cgtgggtgat     1320

gacctcactg ttacgaaccc aaagaggatt gctctagcgg cagaaaagaa ggcatgcaac     1380

tgcttgttgc taaaagtgaa ccaaatcgga tcagtcaccg agagcattga tgctgccaat     1440

ctggctcgca agaatggctg gggcgtcatg gtgtctcatc gctctggtga gacagaggac     1500

acattcatcg ctgatctagt tgtgggtttg gctactggac agatcaaaac aggagctcct     1560

tgccgttccg agcgcctagc gaaatacaat cagatcctgc gaattgagga agaattaggt     1620

tcagcagcga tttatgctgg tcaaaagttt cgcaacccgc aagctggctc ttcaggaaaa     1680

tttactgacg ctgacttcaa agagggcata aagccgtatg acgtgctgtt ggtaaagttt     1740

tatgcgccat ggtgtggtca ctgcaaaaag atcgcgcctg agttcgagaa ggccgcgaca     1800

aaactcttac agaatgaccc tccaatccac ttggctgagg tcgactgtac cgaagagaag     1860

aagacgtgcg atgaatacgg tgtctctggc tttcccacgt tgaagatttt ccgtaagggc     1920

gaactcgcgc aggactatga cggcccaagg gtagctgaag gcattgtgaa gtatatgcgc     1980

ggccaagccg gaccgagtgc aaccgaaatc aatacacagc aagaattcga aaagatgctg     2040

caggccgacg acgtgactat atgtggtttc ttcgaggaga atagtaagct caaagactcc     2100

tttcttaagg tggcggacac cgagagggac aggttcaaat tcgtgtggac ctcaaacaaa     2160

cagatactcg agtcccgtgg atataacgac gacatcgttg cataccaacc gaagaagttc     2220

cataacaagt tcgaacctaa cgaattcaag tacgacggta actacgatac cgacaagatc     2280

aaagagttcc tgttgcacga aaccaatgga ctcgttggaa tccgtaccgc cgaaaataga     2340

taccagtacg acctactgcc gatgttcgtg gtatacggaa aagtcgacta tgagctcgat     2400

cctaagggat ctaactattg gagaaaccga gtacttatgg ttgccaagga ttacaaacgc     2460

aaagctaact tcgctatgag caacaaagag gacttctcgt ttgacttaga cgaattcggt     2520

ctagcgaacc gcaaagacac caagccatta gtcgctgcac gaagcaagaa aggcaagttc     2580

ttcatgaagg aggagttctc cttcagtgtt gagaatctca agaaattcgt cgaggacgtt     2640

atcggagata gactggagcc ttacatgaaa tccgaggaag ccccagaaga tcagggcgat     2700

gtcaaagtcg tagtagcaaa gacatttcag gagatgatta tgaacgttga gaaggatgtt     2760

cttatcgaat tctacgctcc ctggtgtggc cactgtaagg ctctggcccc taaatacgac     2820

gagctcggtc agaagttgag tggtgagcct ggagtggtga tagctaagat ggacgcaacc     2880

gccaacgacg tgcctccacc attccaggtg caaggttttc caacgctata ctgggtccca     2940

aagaacaaga aagataagcc cgagccatat tcaggtggaa gggaggtcga cgacttcatc     3000

aaatacatcg cgaaacacgc taccgaagag ctgaagggtt ataaaagaga tggcaaaccc     3060

aagaagaaag aggagctggg ttctagtggt actgacaaac ttgaacgcat cgaggaagaa     3120

cttcgcgaca cacagaagaa gatgatgcaa actgagaacg atctcgataa ggcccaagag     3180

gatctcgctg tcgctaacac aaacttggaa gaaaaggaga agaaggtgca agaggctgaa     3240

gctgaagtgg ctgcactcaa cagacgcatg acgttactcg aggaagagct ggagagggct     3300

gaggagcgcc taaagatagc caccgataaa ctcgaggagg caacccatac tgctgatgaa     3360

agcgaaagag tccgcaaagt catggagaat cgttccttcc aagatgaaga acgcgcaaac     3420

accgtggaaa gccaactgaa agaagcacag ttgctggcag aggaagccga taggaaatat     3480

gatgaagttg cgagaaagct ggccatggtt gaggctgatt tagaacgcgc ggaagaacgc     3540

gccgaagccg gtgaaaacaa aattgtcgag ctcgaagagg agctgagagt cgtgggcaac     3600

aacttgaagt ctctggaggt atcggaggag aaggccctgc agagggaaga ttcctacgag     3660

gaacaaattc gtaccgtttc agcacgactt aaggaggcgg aaacacgcgc tgaattcgct     3720

gaaaggagtg tgcaaaagct ccagaaagag gtagaccgtc tggaggacga actggtgcac     3780

gaaaaggagc gttacaagaa catctcggag gaattagacc aaacctttca ggagctctca     3840

ggctacgaac agaagctgat cagtgaggaa gatctt                               3876


<210>  53
<211>  207
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GST segment of GST-Cathepsin (GC) Chimera

<400>  53

Ser Tyr Lys Leu Thr Tyr Phe Pro Ile Arg Gly Leu Ala Glu Pro Ile 
1               5                   10                  15      


Arg Leu Leu Leu Val Asp Gln Gly Ile Lys Phe Thr Asp Glu His Ile 
            20                  25                  30          


Pro Lys Asp Asp Phe Val Ser Ile Lys Ser Gln Phe Gln Phe Gly Gln 
        35                  40                  45              


Leu Pro Cys Phe Tyr Asp Gly Asp Gln Gln Ile Val Gln Ser Gly Ala 
    50                  55                  60                  


Ile Leu Arg His Leu Ala Arg Lys Phe Asn Leu Asn Gly Glu Asn Asn 
65                  70                  75                  80  


Ala Glu Thr Ser Tyr Val Asp Met Phe Tyr Glu Gly Ile Arg Asp Leu 
                85                  90                  95      


His Ser Lys Tyr Thr Arg Met Ile Tyr Glu Ala Tyr Glu Thr Gln Lys 
            100                 105                 110         


Asp Pro Phe Ile Lys Asn Ile Leu Pro Gln Glu Leu Ala Lys Leu Glu 
        115                 120                 125             


Lys Leu Leu Ala Thr Arg Asp Asn Gly Lys Asn Phe Ile Leu Gly Asp 
    130                 135                 140                 


Lys Ile Ser Phe Ala Asp Tyr Val Leu Phe Glu Glu Leu Asp Val Gln 
145                 150                 155                 160 


Gln Ile Leu Asp Pro His Cys Leu Glu Lys Phe Pro Leu Leu Lys Ala 
                165                 170                 175     


Phe His Gln Arg Leu Gly Asp Lys Pro Lys Ile Lys Glu Tyr Cys Ala 
            180                 185                 190         


Lys Arg Asn Ala Ser Lys Met Pro Val Asn Gly Asn Gly Lys Gln 
        195                 200                 205         


<210>  54
<211>  515
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cathepsin segment of GC Chimera

<400>  54

Thr Arg Arg Ser Phe Pro Thr Ile Ala Phe His Ser Phe Phe Leu Val 
1               5                   10                  15      


Ser Phe Tyr Pro Ser Leu Phe Ser Asp Arg Asn Gly Gly Arg Gly Arg 
            20                  25                  30          


Gly Arg Asn Lys Val Met Arg Glu Lys Lys Arg Gly Arg Glu Met Glu 
        35                  40                  45              


Arg Asn Val Ser Val Ile Leu Lys Tyr Phe Leu Ser Phe Ile Ile Leu 
    50                  55                  60                  


His Leu Cys Phe Leu Ser Met Val Val Ile Gly Arg Gly His His Ala 
65                  70                  75                  80  


Met Thr Phe Thr Thr Ile Ala Thr Thr Phe Leu Ser Val Leu Thr Ile 
                85                  90                  95      


Ile Thr Leu Cys Asn Lys His Thr Ile Ala Ile Ala Asp Glu Lys Asp 
            100                 105                 110         


His Leu Thr Arg Ile Met Leu His Lys Gln Asp Ser Ile Arg Thr His 
        115                 120                 125             


Leu Ile Lys Ala Gly Ser Trp Glu Ala Tyr Ser Asp Leu Leu Asn Phe 
    130                 135                 140                 


Gln Ile Gln Arg Lys Lys Ile Gln His Lys Ile Glu Ser Asp Leu Asp 
145                 150                 155                 160 


Ser Ala Ser Lys Ser Asp Ala Ile Asp Glu Thr Asp Glu Val Leu Lys 
                165                 170                 175     


Asn Tyr Met Asp Ala Gln Tyr Tyr Gly Gln Ile Ser Ile Gly Thr Pro 
            180                 185                 190         


Pro Gln Asn Phe Ser Val Ile Phe Asp Thr Gly Ser Ser Asn Leu Trp 
        195                 200                 205             


Val Pro Ser Ile Lys Cys Pro Phe Leu Asp Ile Ala Cys Leu Leu His 
    210                 215                 220                 


Asn Lys Tyr Lys Gly Thr Glu Ser Lys Thr Tyr Lys Pro Asp Gly Arg 
225                 230                 235                 240 


Lys Ile Gln Ile Gln Tyr Gly Arg Gly Ser Met Lys Gly Phe Ile Ser 
                245                 250                 255     


Leu Asp Thr Val Cys Ile Ala Asp Ile Cys Val Lys Asn Gln Pro Phe 
            260                 265                 270         


Ala Glu Ala Ile Ala Glu Pro Gly Ala Thr Phe Val Met Ala Lys Phe 
        275                 280                 285             


Asp Gly Ile Leu Gly Met Ala Phe Pro Glu Ile Ala Val Leu Glu Leu 
    290                 295                 300                 


Ser Pro Val Phe His Thr Met Ile Asn Gln Lys Val Leu Gln Gln Pro 
305                 310                 315                 320 


Val Phe Ala Phe Trp Leu Asp Arg Asn Pro Asn Asp Glu Ile Gly Gly 
                325                 330                 335     


Glu Ile Thr Leu Gly Gly Ile Asp Met Asn Arg Phe Val Ser Pro Ile 
            340                 345                 350         


Thr Tyr Thr Pro Ile Ser Arg Leu Gly Tyr Trp Gln Phe Lys Met Asp 
        355                 360                 365             


Ser Ile Gln Gly Asp Asn Glu Ala Ile Gly Cys Ala Lys Gly Cys Gln 
    370                 375                 380                 


Ala Ile Ala Asp Thr Gly Thr Ser Leu Ile Ala Gly Pro Lys Ser Gln 
385                 390                 395                 400 


Val Glu Lys Ile Gln Gln Tyr Ile Gly Ala Glu Tyr Val Phe Ala Gly 
                405                 410                 415     


Glu Tyr Ile Ile Pro Cys Tyr Lys Val Ser Ser Leu Pro Glu Ile Lys 
            420                 425                 430         


Phe Val Ile Ala Gly Lys Ser Tyr Ala Leu Lys Gly Ser Asp Tyr Val 
        435                 440                 445             


Leu Asn Val Thr Ser Lys Gly Lys Ser Ile Cys Leu Ser Gly Phe Met 
    450                 455                 460                 


Gly Ile Asp Leu Pro Glu Arg Leu Gly Glu Leu Trp Ile Leu Gly Asp 
465                 470                 475                 480 


Val Phe Ile Gly Arg Tyr Tyr Thr Val Phe Asp Val Gly Asn Ala Gln 
                485                 490                 495     


Ile Gly Phe Ala Gln Ala Arg Asp Ser Lys Gly Lys Pro Val Gly Lys 
            500                 505                 510         


Arg Val Asn 
        515 


<210>  55
<211>  757
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GC Chimera with 5' Murine IgK chain leader and 3' C-myc tag

<400>  55

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ser Tyr Lys Leu Thr Tyr Phe Pro Ile Arg Gly 
            20                  25                  30          


Leu Ala Glu Pro Ile Arg Leu Leu Leu Val Asp Gln Gly Ile Lys Phe 
        35                  40                  45              


Thr Asp Glu His Ile Pro Lys Asp Asp Phe Val Ser Ile Lys Ser Gln 
    50                  55                  60                  


Phe Gln Phe Gly Gln Leu Pro Cys Phe Tyr Asp Gly Asp Gln Gln Ile 
65                  70                  75                  80  


Val Gln Ser Gly Ala Ile Leu Arg His Leu Ala Arg Lys Phe Asn Leu 
                85                  90                  95      


Asn Gly Glu Asn Asn Ala Glu Thr Ser Tyr Val Asp Met Phe Tyr Glu 
            100                 105                 110         


Gly Ile Arg Asp Leu His Ser Lys Tyr Thr Arg Met Ile Tyr Glu Ala 
        115                 120                 125             


Tyr Glu Thr Gln Lys Asp Pro Phe Ile Lys Asn Ile Leu Pro Gln Glu 
    130                 135                 140                 


Leu Ala Lys Leu Glu Lys Leu Leu Ala Thr Arg Asp Asn Gly Lys Asn 
145                 150                 155                 160 


Phe Ile Leu Gly Asp Lys Ile Ser Phe Ala Asp Tyr Val Leu Phe Glu 
                165                 170                 175     


Glu Leu Asp Val Gln Gln Ile Leu Asp Pro His Cys Leu Glu Lys Phe 
            180                 185                 190         


Pro Leu Leu Lys Ala Phe His Gln Arg Leu Gly Asp Lys Pro Lys Ile 
        195                 200                 205             


Lys Glu Tyr Cys Ala Lys Arg Asn Ala Ser Lys Met Pro Val Asn Gly 
    210                 215                 220                 


Asn Gly Lys Gln Gly Ser Ser Gly Thr Arg Arg Ser Phe Pro Thr Ile 
225                 230                 235                 240 


Ala Phe His Ser Phe Phe Leu Val Ser Phe Tyr Pro Ser Leu Phe Ser 
                245                 250                 255     


Asp Arg Asn Gly Gly Arg Gly Arg Gly Arg Asn Lys Val Met Arg Glu 
            260                 265                 270         


Lys Lys Arg Gly Arg Glu Met Glu Arg Asn Val Ser Val Ile Leu Lys 
        275                 280                 285             


Tyr Phe Leu Ser Phe Ile Ile Leu His Leu Cys Phe Leu Ser Met Val 
    290                 295                 300                 


Val Ile Gly Arg Gly His His Ala Met Thr Phe Thr Thr Ile Ala Thr 
305                 310                 315                 320 


Thr Phe Leu Ser Val Leu Thr Ile Ile Thr Leu Cys Asn Lys His Thr 
                325                 330                 335     


Ile Ala Ile Ala Asp Glu Lys Asp His Leu Thr Arg Ile Met Leu His 
            340                 345                 350         


Lys Gln Asp Ser Ile Arg Thr His Leu Ile Lys Ala Gly Ser Trp Glu 
        355                 360                 365             


Ala Tyr Ser Asp Leu Leu Asn Phe Gln Ile Gln Arg Lys Lys Ile Gln 
    370                 375                 380                 


His Lys Ile Glu Ser Asp Leu Asp Ser Ala Ser Lys Ser Asp Ala Ile 
385                 390                 395                 400 


Asp Glu Thr Asp Glu Val Leu Lys Asn Tyr Met Asp Ala Gln Tyr Tyr 
                405                 410                 415     


Gly Gln Ile Ser Ile Gly Thr Pro Pro Gln Asn Phe Ser Val Ile Phe 
            420                 425                 430         


Asp Thr Gly Ser Ser Asn Leu Trp Val Pro Ser Ile Lys Cys Pro Phe 
        435                 440                 445             


Leu Asp Ile Ala Cys Leu Leu His Asn Lys Tyr Lys Gly Thr Glu Ser 
    450                 455                 460                 


Lys Thr Tyr Lys Pro Asp Gly Arg Lys Ile Gln Ile Gln Tyr Gly Arg 
465                 470                 475                 480 


Gly Ser Met Lys Gly Phe Ile Ser Leu Asp Thr Val Cys Ile Ala Asp 
                485                 490                 495     


Ile Cys Val Lys Asn Gln Pro Phe Ala Glu Ala Ile Ala Glu Pro Gly 
            500                 505                 510         


Ala Thr Phe Val Met Ala Lys Phe Asp Gly Ile Leu Gly Met Ala Phe 
        515                 520                 525             


Pro Glu Ile Ala Val Leu Glu Leu Ser Pro Val Phe His Thr Met Ile 
    530                 535                 540                 


Asn Gln Lys Val Leu Gln Gln Pro Val Phe Ala Phe Trp Leu Asp Arg 
545                 550                 555                 560 


Asn Pro Asn Asp Glu Ile Gly Gly Glu Ile Thr Leu Gly Gly Ile Asp 
                565                 570                 575     


Met Asn Arg Phe Val Ser Pro Ile Thr Tyr Thr Pro Ile Ser Arg Leu 
            580                 585                 590         


Gly Tyr Trp Gln Phe Lys Met Asp Ser Ile Gln Gly Asp Asn Glu Ala 
        595                 600                 605             


Ile Gly Cys Ala Lys Gly Cys Gln Ala Ile Ala Asp Thr Gly Thr Ser 
    610                 615                 620                 


Leu Ile Ala Gly Pro Lys Ser Gln Val Glu Lys Ile Gln Gln Tyr Ile 
625                 630                 635                 640 


Gly Ala Glu Tyr Val Phe Ala Gly Glu Tyr Ile Ile Pro Cys Tyr Lys 
                645                 650                 655     


Val Ser Ser Leu Pro Glu Ile Lys Phe Val Ile Ala Gly Lys Ser Tyr 
            660                 665                 670         


Ala Leu Lys Gly Ser Asp Tyr Val Leu Asn Val Thr Ser Lys Gly Lys 
        675                 680                 685             


Ser Ile Cys Leu Ser Gly Phe Met Gly Ile Asp Leu Pro Glu Arg Leu 
    690                 695                 700                 


Gly Glu Leu Trp Ile Leu Gly Asp Val Phe Ile Gly Arg Tyr Tyr Thr 
705                 710                 715                 720 


Val Phe Asp Val Gly Asn Ala Gln Ile Gly Phe Ala Gln Ala Arg Asp 
                725                 730                 735     


Ser Lys Gly Lys Pro Val Gly Lys Arg Val Asn Glu Gln Lys Leu Ile 
            740                 745                 750         


Ser Glu Glu Asp Leu 
        755         


<210>  56
<211>  621
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GST segment of GST-Cathepsin (GC) Chimera

<400>  56
tcctacaagt taacctactt ccccataaga ggcctggccg aaccaatcag actgctcttg       60

gtcgaccagg gtatcaaatt cacggatgag cacatcccta aagacgattt cgtcagcatc      120

aagagccagt ttcagttcgg tcaactcccc tgcttctatg acggcgacca acagatagtg      180

caaagtggcg ctattctgcg tcacttggct cgaaagttca acctcaacgg tgagaacaac      240

gccgagactt catatgtgga catgttctac gagggtatac gcgacttgca ttccaaatac      300

acccgtatga tctatgaagc ctacgagaca cagaaagacc cgttcatcaa gaacatactg      360

cctcaagagc ttgcaaagct ggagaaacta ttagccacac gagataatgg caagaacttc      420

atcttaggtg acaaaatctc cttcgcggat tacgttctat tcgaggagct cgatgtccag      480

cagatcctag acccacattg tctggaaaag ttccccttgt taaaggcttt tcaccagaga      540

ctgggcgaca aacccaagat caaggaatat tgcgccaaaa ggaatgcatc caagatgcct      600

gtaaatggca atggtaagca g                                                621


<210>  57
<211>  1545
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cathepsin segment of GC Chimera

<400>  57
acccgcagat cttttcccac gatcgccttt cactctttct ttctagtgtc gttttaccca       60

agtctgtttt cggatcgcaa cggtggacgc ggaaggggtc gcaacaaagt gatgagggag      120

aagaagagag gacgtgagat ggaacgcaat gtaagtgtca ttctcaaata cttcctttcc      180

ttcattatcc tgcatctgtg ctttctctca atggtcgtta ttggccgagg ccatcacgca      240

atgacgttca ctactatcgc aaccaccttc ctgtctgtgc ttacaatcat cactctctgc      300

aacaagcaca ctatagctat cgcggatgaa aaggaccact tgactcgcat catgctgcat      360

aagcaggatt ccattcgcac acacctgata aaagcgggat catgggaagc ttattcagac      420

ctgttgaact tccaaatcca gcgtaagaag attcagcaca aaatcgagtc cgacttagac      480

agtgcatcaa agtctgacgc cattgatgaa acagacgagg tccttaagaa ttacatggat      540

gctcagtact acggccagat aagcatcggt acccctccac aaaacttctc cgtcatcttc      600

gacacaggct catctaacct ttgggtcccg tctattaagt gcccgttctt ggatatcgcc      660

tgtttgttgc acaacaaata caagggaacg gaatcaaaga catacaagcc tgacggtcgt      720

aaaatccaga ttcaatacgg tcgtggttcg atgaagggct tcatttcgct tgacaccgtg      780

tgtatagctg atatctgcgt caagaaccaa cctttcgccg aagctatagc tgaacctggt      840

gcgactttcg taatggcgaa attcgacggc atcctcggta tggcattccc tgagattgct      900

gtactggaac taagcccagt attccatacc atgattaacc aaaaggtcct ccaacagccg      960

gtattcgcgt tttggctgga cagaaaccca aacgatgaga ttggcggaga aatcactttg     1020

ggcggaatcg acatgaatcg ctttgtttct ccgataacct acactcctat ctcgcgtcta     1080

ggatattggc agttcaagat ggactctatc caaggcgata acgaggctat cggttgtgcc     1140

aagggttgtc aggccattgc tgacacaggt actagcctga ttgctggccc caagagccaa     1200

gttgagaaaa ttcagcaata tatcggagcc gaatacgtgt ttgcaggaga atacatcatt     1260

ccctgctaca aggttagcag tttgcccgag atcaaattcg ttatcgccgg taaatcgtac     1320

gcacttaagg gttcagacta tgtgttgaat gtgacgagta agggaaaatc catctgcctc     1380

tcaggcttca tgggtataga tctgccagag aggctgggag agctctggat cttgggagat     1440

gtgttcattg gacgctacta caccgttttc gacgttggta atgcgcaaat tggatttgct     1500

caggctaggg atagtaaggg caaacccgtg ggtaagaggg tgaac                     1545


<210>  58
<211>  2271
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GC Chimera with 5' Murine IgK chain leader and 3' C-myc tag

<400>  58
atggaaacgg ataccttatt actctgggtg ctcttgctct gggtcccagg tagcaccgga       60

gactcctaca agttaaccta cttccccata agaggcctgg ccgaaccaat cagactgctc      120

ttggtcgacc agggtatcaa attcacggat gagcacatcc ctaaagacga tttcgtcagc      180

atcaagagcc agtttcagtt cggtcaactc ccctgcttct atgacggcga ccaacagata      240

gtgcaaagtg gcgctattct gcgtcacttg gctcgaaagt tcaacctcaa cggtgagaac      300

aacgccgaga cttcatatgt ggacatgttc tacgagggta tacgcgactt gcattccaaa      360

tacacccgta tgatctatga agcctacgag acacagaaag acccgttcat caagaacata      420

ctgcctcaag agcttgcaaa gctggagaaa ctattagcca cacgagataa tggcaagaac      480

ttcatcttag gtgacaaaat ctccttcgcg gattacgttc tattcgagga gctcgatgtc      540

cagcagatcc tagacccaca ttgtctggaa aagttcccct tgttaaaggc ttttcaccag      600

agactgggcg acaaacccaa gatcaaggaa tattgcgcca aaaggaatgc atccaagatg      660

cctgtaaatg gcaatggtaa gcagggaagc tctggtaccc gcagatcttt tcccacgatc      720

gcctttcact ctttctttct agtgtcgttt tacccaagtc tgttttcgga tcgcaacggt      780

ggacgcggaa ggggtcgcaa caaagtgatg agggagaaga agagaggacg tgagatggaa      840

cgcaatgtaa gtgtcattct caaatacttc ctttccttca ttatcctgca tctgtgcttt      900

ctctcaatgg tcgttattgg ccgaggccat cacgcaatga cgttcactac tatcgcaacc      960

accttcctgt ctgtgcttac aatcatcact ctctgcaaca agcacactat agctatcgcg     1020

gatgaaaagg accacttgac tcgcatcatg ctgcataagc aggattccat tcgcacacac     1080

ctgataaaag cgggatcatg ggaagcttat tcagacctgt tgaacttcca aatccagcgt     1140

aagaagattc agcacaaaat cgagtccgac ttagacagtg catcaaagtc tgacgccatt     1200

gatgaaacag acgaggtcct taagaattac atggatgctc agtactacgg ccagataagc     1260

atcggtaccc ctccacaaaa cttctccgtc atcttcgaca caggctcatc taacctttgg     1320

gtcccgtcta ttaagtgccc gttcttggat atcgcctgtt tgttgcacaa caaatacaag     1380

ggaacggaat caaagacata caagcctgac ggtcgtaaaa tccagattca atacggtcgt     1440

ggttcgatga agggcttcat ttcgcttgac accgtgtgta tagctgatat ctgcgtcaag     1500

aaccaacctt tcgccgaagc tatagctgaa cctggtgcga ctttcgtaat ggcgaaattc     1560

gacggcatcc tcggtatggc attccctgag attgctgtac tggaactaag cccagtattc     1620

cataccatga ttaaccaaaa ggtcctccaa cagccggtat tcgcgttttg gctggacaga     1680

aacccaaacg atgagattgg cggagaaatc actttgggcg gaatcgacat gaatcgcttt     1740

gtttctccga taacctacac tcctatctcg cgtctaggat attggcagtt caagatggac     1800

tctatccaag gcgataacga ggctatcggt tgtgccaagg gttgtcaggc cattgctgac     1860

acaggtacta gcctgattgc tggccccaag agccaagttg agaaaattca gcaatatatc     1920

ggagccgaat acgtgtttgc aggagaatac atcattccct gctacaaggt tagcagtttg     1980

cccgagatca aattcgttat cgccggtaaa tcgtacgcac ttaagggttc agactatgtg     2040

ttgaatgtga cgagtaaggg aaaatccatc tgcctctcag gcttcatggg tatagatctg     2100

ccagagaggc tgggagagct ctggatcttg ggagatgtgt tcattggacg ctactacacc     2160

gttttcgacg ttggtaatgc gcaaattgga tttgctcagg ctagggatag taagggcaaa     2220

cccgtgggta agagggtgaa cgaacaaaag ctgatttccg aagaggacct t              2271


