                         SEQUENCE LISTING

<110>  Hemogenix
       Sandler, Vladislav
 
<120>  Method of Eliminating Hematopoietic Stem Cells/Hematopoietic 
       Progenitors (HSC/HP) in a Patient Using Bi-Specific Antibodies

<130>  18133.0005

<140>  PCT/US2017/025951
<141>  2017-04-04

<150>  US 62/317,906
<151>  2016-04-04

<160>  20    

<170>  PatentIn version 3.5

<210>  1
<211>  613
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys 
            20                  25                  30          


Pro Gly Ala Ser Leu Lys Leu Ser Cys Lys Ser Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Ser Tyr Trp Met His Trp Val Arg Gln Arg Pro Gly His Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Glu Ile Asp Pro Ser Asp Ser Tyr Lys Asp Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Lys Asp Lys Ala Thr Leu Thr Val Asp Arg Ser Ser Asn 
                85                  90                  95      


Thr Ala Tyr Met His Leu Ser Ser Leu Thr Ser Asp Asp Ser Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Ala Ile Thr Thr Thr Pro Phe Asp Phe Trp Gly 
        115                 120                 125             


Gln Gly Thr Thr Leu Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
    130                 135                 140                 


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
145                 150                 155                 160 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
                165                 170                 175     


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
            180                 185                 190         


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
        195                 200                 205             


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
    210                 215                 220                 


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
225                 230                 235                 240 


Asp Lys Thr His Thr Ser Pro Pro Ser Pro Ala Pro Pro Val Ala Gly 
                245                 250                 255     


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
            260                 265                 270         


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Gly Val Ser His Glu 
        275                 280                 285             


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
    290                 295                 300                 


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Gln Ser Thr Tyr Arg 
305                 310                 315                 320 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
                325                 330                 335     


Glu Tyr Lys Cys Lys Val Ser Asn Lys Gln Leu Pro Ser Pro Ile Glu 
            340                 345                 350         


Lys Thr Ile Ser Lys Ala Lys Gly Gly Gly Gly Ala Gly Gly Gly Gly 
        355                 360                 365             


Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
    370                 375                 380                 


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
385                 390                 395                 400 


Thr Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
                405                 410                 415     


Ala Leu Ile Asn Pro Tyr Lys Gly Val Thr Thr Tyr Ala Asp Ser Val 
            420                 425                 430         


Lys Gly Arg Phe Thr Ile Ser Val Asp Lys Ser Lys Asn Thr Ala Tyr 
        435                 440                 445             


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
    450                 455                 460                 


Ala Arg Ser Gly Tyr Tyr Gly Asp Ser Asp Trp Tyr Phe Asp Val Trp 
465                 470                 475                 480 


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
                485                 490                 495     


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser 
            500                 505                 510         


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
        515                 520                 525             


Arg Ala Ser Gln Asp Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys 
    530                 535                 540                 


Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Tyr Thr Ser Arg Leu Glu 
545                 550                 555                 560 


Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr 
                565                 570                 575     


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
            580                 585                 590         


Cys Gln Gln Gly Asn Thr Leu Pro Trp Thr Phe Gly Gln Gly Thr Lys 
        595                 600                 605             


Val Glu Ile Lys Arg 
    610             


<210>  2
<211>  234
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser 
            20                  25                  30          


Val Thr Pro Gly Asp Ser Val Ser Leu Ser Cys Arg Ala Ser Gln Ser 
        35                  40                  45              


Ile Ser Asn Asn Leu His Trp Tyr Gln Gln Lys Ser His Glu Ser Pro 
    50                  55                  60                  


Arg Leu Leu Ile Lys Tyr Ala Ser Gln Ser Ile Ser Gly Ile Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Asn 
                85                  90                  95      


Ser Val Glu Thr Glu Asp Phe Gly Val Tyr Phe Cys Gln Gln Ser Asn 
            100                 105                 110         


Thr Trp Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  3
<211>  1842
<212>  DNA
<213>  Homo sapiens

<400>  3
atggaatgga gctgggtctt tctcttcttc ctgtcagtaa cgactggtgt ccactcccag       60

gtgcagctgc agcagcctgg tgccgagctc gtgaaacctg gcgcctccct gaagctgtcc      120

tgcaagtcct ccggctacac cttcaccagc tactggatgc actgggtgcg acagaggcct      180

ggccacggac tggaatggat cggcgagatc gacccctccg actcctacaa ggactacaac      240

cagaagttca aggacaaggc caccctgacc gtggacagat cctccaacac cgcctacatg      300

cacctgtcct ccctgacctc cgacgactcc gccgtgtact actgcgccag agccatcaca      360

accaccccct tcgatttctg gggccagggc accacactga cagtgtcctc cgcttccacc      420

aagggcccct ccgtgtttcc tctggcccct tccagcaagt ccacctctgg cggaacagcc      480

gctctgggct gcctcgtgaa ggactacttc cccgagcctg tgaccgtgtc ctggaactct      540

ggcgctctga catccggcgt gcacaccttc cctgctgtgc tgcagtctag cggcctgtac      600

tccctgtcca gcgtcgtgac cgtgccttcc agctctctgg gcacccagac ctacatctgc      660

aacgtgaacc acaagccttc caacaccaag gtggacaaga aggtggaacc caagtcctgc      720

gacaagaccc acaccagccc tccaagccct gctcctcctg tggctggccc tagcgtgttc      780

ctgttccctc caaagcccaa ggataccctg atgatctccc ggacccccga agtgacctgc      840

gtggtcgtgg gagtgtctca cgaggaccct gaagtgaagt tcaattggta cgtggacggc      900

gtggaagtgc acaacgccaa gaccaagcct agagaggaac agtaccagtc cacctaccgg      960

gtggtgtccg tgctgaccgt gctgcaccag gattggctga acggcaaaga gtacaagtgc     1020

aaggtgtcca acaagcagct gcccagcccc atcgaaaaga ccatctccaa ggctaagggc     1080

ggaggcggag ctggtggtgg cggagaagtg cagctggtgg aatctggcgg cggactggtg     1140

cagcctggcg gatctctgag actgtcttgt gccgccagcg gctactcttt caccggctat     1200

accatgaatt gggtgcgcca ggcccctgga aagggcctgg aatgggtggc cctgatcaac     1260

ccctacaagg gcgtgaccac ctacgccgac tccgtgaagg gccggttcac catctccgtg     1320

gacaagtcca agaataccgc ttacctgcag atgaactccc tgcgggccga ggacaccgct     1380

gtgtattact gtgctagatc cggctactac ggcgacagcg attggtactt cgacgtgtgg     1440

ggacagggaa ccctcgtgac tgtgtcatca ggcggcggtg gttctggcgg agggggatct     1500

gggggcggtg gatccgatat ccagatgacc cagtccccca gctccctgtc tgcctctgtg     1560

ggcgacagag tgaccatcac ctgtcgggcc tctcaggaca tccggaacta cctgaactgg     1620

tatcagcaga agcccggcaa ggcccccaag ctgctgatct actacacctc ccggctggaa     1680

agcggcgtgc cctccagatt ctccggctct ggctctggaa ccgactatac cctgaccatc     1740

tctagcctgc agcccgagga cttcgccacc tactactgcc agcagggcaa caccctgccc     1800

tggacctttg gccagggaac aaaggtggaa atcaagcggt ga                        1842


<210>  4
<211>  705
<212>  DNA
<213>  Homo sapiens

<400>  4
atggagaccg acaccctgct gctctgggtg ctgctgctct gggtgcccgg ctccaccgga       60

gacatcgtgc tgacccagtc tcccgccacc ctgtctgtga cccctggcga ctctgtgtcc      120

ctgtcctgca gagcctccca gtccatctcc aacaacctgc actggtatca gcagaagtcc      180

cacgagagcc ctcggctgct gattaagtac gccagccagt ctatctccgg catcccctcc      240

agattctccg gctctggctc tggcaccgac ttcaccctgt ccatcaactc cgtggaaacc      300

gaggacttcg gcgtgtactt ctgccagcag tccaacacct ggccctacac ctttggcgga      360

ggcaccaagc tggaaatcaa gcggaccgtg gccgccccca gcgtgttcat cttccctccc      420

agcgacgagc agctgaagtc tggcaccgcc agcgtggtgt gcctgctgaa caacttctac      480

ccccgcgagg ccaaggtgca gtggaaggtg gacaacgccc tgcagagcgg caacagccag      540

gagagcgtga ccgagcagga ctccaaggac agcacctaca gcctgagcag caccctgacc      600

ctgagcaagg ccgactacga gaagcacaag gtgtacgcct gcgaggtgac ccaccaggga      660

ctgtctagcc ccgtgaccaa gagcttcaac cggggcgagt gctaa                      705


<210>  5
<211>  107
<212>  PRT
<213>  Mus musculus

<400>  5

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Ser Leu Thr Cys Arg Ala Ser Gln Glu Ile Ser Gly Tyr 
            20                  25                  30          


Leu Ser Trp Leu Gln Gln Lys Pro Asp Gly Thr Ile Lys Arg Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu His Ser Gly Val Pro Lys Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Ser Asp Tyr Ser Leu Thr Ile Ser Arg Leu Glu Ser 
65                  70                  75                  80  


Glu Asp Val Ala Asp Tyr Tyr Cys Leu Gln Tyr Ala Ser Tyr Pro Phe 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Arg 
            100                 105         


<210>  6
<211>  321
<212>  DNA
<213>  Mus musculus

<400>  6
gacatccaga tgacccagtc tccatcctcc ttatctgcct ctctgggaga aagagtcagt       60

ctcacttgtc gggcaagtca ggaaattagt ggttacttaa gctggcttca gcagaaacca      120

gatggaacta ttaaacgcct gatctacgcc gcatccactt tacattctgg tgtcccaaaa      180

aggttcagtg gcagtaggtc tgggtcagat tactctctca ccatcagcag gcttgagtct      240

gaagatgttg cagactatta ctgtctacaa tatgctagtt atccattcac gttcggctcg      300

gggacaaagt tggaaataag a                                                321


<210>  7
<211>  123
<212>  PRT
<213>  Mus musculus

<400>  7

Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Ile Leu Gln Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Ser Thr Ser 
            20                  25                  30          


Thr Met Gly Val Gly Trp Ile Arg Gln Pro Ser Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Leu Leu His Ile Leu Trp Asn Asp Ser Lys Tyr Tyr Asn Pro Ala 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Tyr Asn Lys Gln Val 
65                  70                  75                  80  


Phe Leu Lys Ile Ala Asn Val Asp Thr Ala Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Ile Val Tyr Tyr Ser Thr Tyr Val Gly Tyr Phe Asp Val 
            100                 105                 110         


Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  8
<211>  369
<212>  DNA
<213>  Mus musculus

<400>  8
caggttactc tgaaagagtc tggccctggg atattgcagc cctcccagac cctcagtctg       60

acttgttctt tctctgggtt ttctctgagc acttctacta tgggtgtagg ctggattcgt      120

cagccttcag ggaagggtct ggagtggctg ttacacattt tgtggaatga tagtaagtat      180

tataacccag ccctgaagag ccggctcaca atctccaagg atacctacaa caagcaggta      240

ttcctcaaga tcgccaatgt ggacactgca gatactgcca catactactg tgctcgaata      300

gtttactact ctacctacgt cgggtacttc gatgtctggg gcgcagggac cacggtcacc      360

gtctcctca                                                              369


<210>  9
<211>  111
<212>  PRT
<213>  Mus musculus

<400>  9

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Asn Tyr 
            20                  25                  30          


Gly Ile Ser Phe Met Asn Trp Phe Gln Gln Lys Pro Gly Gln Ser Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Ala Val Ser Asn Gln Gly Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu Asn Ile His 
65                  70                  75                  80  


Pro Met Glu Glu Asp Asp Thr Ala Met Tyr Phe Cys Gln Gln Ser Lys 
                85                  90                  95      


Glu Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  10
<211>  333
<212>  DNA
<213>  Mus musculus

<400>  10
gacattgtgc tgacccaatc tccagcttct ttggctgtgt ctctagggca gagggccacc       60

atctcctgca gagccagcga aagtgttgat aattatggca ttagttttat gaactggttc      120

caacagaaac caggacagtc acccaaactc ctcatctatg ctgtatccaa ccaaggatcc      180

ggggtccctg ccaggtttag tggcagtggg tctgggacag acttcagcct caacatccat      240

cctatggagg aggatgatac tgcaatgtat ttctgtcagc aaagtaagga ggttccgtgg      300

acgttcggtg gaggcaccaa gctggaaatc aaa                                   333


<210>  11
<211>  116
<212>  PRT
<213>  Mus musculus

<400>  11

Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Leu Val Lys Leu Ser Cys Lys Gly Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Lys Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Glu Asn Asp Ile Thr Met Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Lys Ala Ser Ile Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asn Gly Asn Phe Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ala 
        115     


<210>  12
<211>  348
<212>  DNA
<213>  Mus musculus

<400>  12
gaggttcagc tgcagcagtc tggggctgag cttgtgaggc caggggcctt agtcaagttg       60

tcctgcaaag gttctggctt caacattaaa gactactata tacactgggt gaagcagagg      120

cctgaacagg gcctggagtg gattggaagg attgatcctg agaatgatat tactatgtat      180

gacccgaagt tccagggcaa ggccagtata acagcagaca catcctccaa cacagcctac      240

ctgcagctca gcagcctgac atctgaggac actgccgtct attactgtgc tagaaatggt      300

aatttctttg cttactgggg ccaagggact ctggtcactg tctctgca                   348


<210>  13
<211>  107
<212>  PRT
<213>  Mus musculus

<400>  13

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Ser Leu Thr Cys Arg Ala Ser Gln Glu Ile Ser Gly Tyr 
            20                  25                  30          


Leu Ser Trp Leu Gln Gln Lys Pro Asp Gly Thr Ile Lys Arg Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Asn Ser Gly Val Pro Arg Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Ser Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Asp Tyr Tyr Cys Leu Gln Tyr Ala Ser Tyr Pro Phe 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  14
<211>  321
<212>  DNA
<213>  Mus musculus

<400>  14
gacatccaga tgacccagtc tccatcctcc ttatctgcct ctctgggaga aagagtcagt       60

ctcacttgtc gggcaagtca ggaaattagt ggttacttaa gctggcttca gcagaaacca      120

gatggaacta ttaaacgcct gatctacgcc gcatccactt taaattctgg tgtcccaaga      180

aggttcagtg gcagtaggtc tgggtcagat tattctctca ccatcagcag ccttgagtct      240

gaagattttg cagactatta ctgtctacaa tatgctagtt atccattcac gttcggctcg      300

gggacaaagt tggaaataaa a                                                321


<210>  15
<211>  124
<212>  PRT
<213>  Mus musculus

<400>  15

Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Ile Leu Gln Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Ser Thr Ser 
            20                  25                  30          


His Met Gly Val Gly Trp Ile Arg Gln Pro Ser Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Leu Leu His Ile Leu Trp Asn Asp Ser Val Tyr Tyr Asn Pro Ala 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Tyr Asn Lys Gln Val 
65                  70                  75                  80  


Phe Leu Lys Ile Ala Asn Val Asp Thr Ala Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Ile Val Tyr Tyr Gly Ile Ser Tyr Val Gly Tyr Phe Asp 
            100                 105                 110         


Val Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 


<210>  16
<211>  372
<212>  DNA
<213>  Mus musculus

<400>  16
caggttactc tgaaagagtc tggccctggg atattgcagc cctcccagac cctcagtctg       60

acttgttctt tctctgggtt ttcactgagc acttctcaca tgggtgtagg ctggattcgt      120

cagccttcag ggaagggtct ggagtggctg ttacacattt tgtggaatga tagtgtgtac      180

tataacccag ccctgaagag ccggctcaca atctccaagg atacctacaa caagcaggta      240

ttcctcaaga tcgccaatgt ggacactgca gatactgcca catactactg tgctcgaata      300

gtttactacg gtattagtta cgtcgggtac ttcgatgtct ggggcgcagg gaccacggtc      360

accgtctcct ca                                                          372


<210>  17
<211>  107
<212>  PRT
<213>  Mus musculus

<400>  17

Asp Thr Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Asp Ser Val Ser Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Asn Asn 
            20                  25                  30          


Leu His Trp Tyr Gln Gln Lys Ser His Glu Ser Pro Arg Leu Leu Ile 
        35                  40                  45              


Lys Tyr Gly Phe Gln Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile Asn Ser Val Glu Thr 
65                  70                  75                  80  


Glu Asp Phe Gly Met Tyr Phe Cys Gln Gln Thr Asn Ser Trp Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  18
<211>  321
<212>  DNA
<213>  Mus musculus

<400>  18
gatactgtgc taactcaatc tccagccacc ctgtctgtga ctccaggaga tagcgtcagt       60

ctttcctgca gggccagcca aagtattagc aacaacctac actggtatca acaaaaatca      120

catgagtctc caaggcttct catcaagtat ggtttccagt ccatctctgg gatcccctcc      180

aggttcagtg gcagtggatc agggacagat ttcactctca gaatcaacag tgtggagact      240

gaagattttg gaatgtattt ctgtcaacag actaacagct ggccgctcac gttcggtgct      300

gggaccaagc tggagctgaa a                                                321


<210>  19
<211>  115
<212>  PRT
<213>  Mus musculus

<400>  19

Glu Ile Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Ile Asp Tyr 
            20                  25                  30          


Asn Met Tyr Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Tyr Asn Gly Gly Thr Ser Asn Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Phe 
65                  70                  75                  80  


Met His Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Thr Thr Gly Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  20
<211>  345
<212>  DNA
<213>  Mus musculus

<400>  20
gagatccagc tgcagcagtc tggacctgaa ctggtgaagc ctggggcttc agtgaaggta       60

tcctgcaagg cttctggtta ctcattcatt gactacaaca tgtactgggt gaagcagagc      120

catggaaaga gccttgagtg gattggatat attaatcctt acaatggtgg tactagcaac      180

aaccagaagt tcaaggacaa ggccacattg actgttgaca agtcctccag cacagccttc      240

atgcatctca acagcctgac atctgaggac tctgcagtct attactgtgc aagaggtact      300

acgggtgact actggggcca aggcaccact ctcacagtct cctca                      345


