                         SEQUENCE LISTING

<110>  The United States of America, as represented by the 
       Secretary, Department of Health and Human Services
       Johnson, Reed
 
<120>  MULTIVALENT VACCINES FOR RABIES VIRUS AND CORONOVIRUSES

<130>  1420378.443WO2

<140>  TBD
<141>  2017-03-31

<150>  62/318,087
<151>  2016-04-04

<160>  24    

<170>  PatentIn version 3.5

<210>  1
<211>  30119
<212>  DNA
<213>  Middle East Respiratory Syndrome Coronavirus

<400>  1
gatttaagtg aatagcttgg ctatctcact tcccctcgtt ctcttgcaga actttgattt       60

taacgaactt aaataaaagc cctgttgttt agcgtatcgt tgcacttgtc tggtgggatt      120

gtggcattaa tttgcctgct catctaggca gtggacatat gctcaacact gggtataatt      180

ctaattgaat actatttttc agttagagcg tcgtgtctct tgtacgtctc ggtcacaata      240

cacggtttcg tccggtgcgt ggcaattcgg ggcacatcat gtctttcgtg gctggtgtga      300

ccgcgcaagg tgcgcgcggt acgtatcgag cagcgctcaa ctctgaaaaa catcaagacc      360

atgtgtctct aactgtgcca ctctgtggtt caggaaacct ggttgaaaaa ctttcaccat      420

ggttcatgga tggcgaaaat gcctatgaag tggtgaaggc catgttactt aaaaaggagc      480

cacttctcta tgtgcccatc cggctggctg gacacactag acacctccca ggtcctcgtg      540

tgtacctggt tgagaggctc attgcttgtg aaaatccatt catggttaac caattggctt      600

atagctctag tgcaaatggc agcctggttg gcacaacttt gcagggcaag cctattggta      660

tgttcttccc ttatgacatc gaacttgtca caggaaagca aaatattctc ctgcgcaagt      720

atggccgtgg tggttatcac tacaccccat tccactatga gcgagacaac acctcttgcc      780

ctgagtggat ggacgatttt gaggcggatc ctaaaggcaa atatgcccag aatctgctta      840

agaagttgat tggcggtgat gtcactccag ttgaccaata catgtgtggc gttgatggaa      900

aacccattag tgcctacgca tttttaatgg ccaaggatgg aataaccaaa ctggctgatg      960

ttgaagcgga cgtcgcagca cgtgctgatg acgaaggctt catcacatta aagaacaatc     1020

tatatagatt ggtttggcat gttgagcgta aagacgttcc atatcctaag caatctattt     1080

ttactattaa tagtgtggtc caaaaggatg gtgttgaaaa cactcctcct cactatttta     1140

ctcttggatg caaaatttta acgctcaccc cacgcaacaa gtggagtggc gtttctgact     1200

tgtccctcaa acaaaaactc ctttacacct tctatggtaa ggagtcactt gagaacccaa     1260

cctacattta ccactccgca ttcattgagt gtggaagttg tggtaatgat tcctggctta     1320

cagggaatgc tatccaaggg tttgcctgtg gatgtggggc atcatataca gctaatgatg     1380

tcgaagtcca atcatctggc atgattaagc caaatgctct tctttgtgct acttgcccct     1440

ttgctaaggg tgatagctgt tcttctaatt gcaaacattc agttgctcag ttggttagtt     1500

acctttctga acgctgtaat gttattgctg attctaagtc cttcacactt atctttggtg     1560

gcgtagctta cgcctacttt ggatgtgagg aaggtactat gtactttgtg cctagagcta     1620

agtctgttgt ctcaaggatt ggagactcca tctttacagg ctgtactggc tcttggaaca     1680

aggtcactca aattgctaac atgttcttgg aacagactca gcattccctt aactttgtgg     1740

gagagttcgt tgtcaacgat gttgtcctcg caattctctc tggaaccaca actaatgttg     1800

acaaaatacg ccagcttctc aaaggtgtca cccttgacaa gttgcgtgat tatttagctg     1860

actatgacgt agcagtcact gccggcccat tcatggataa tgctattaat gttggtggta     1920

caggattaca gtatgccgcc attactgcac cttatgtagt tctcactggc ttaggtgagt     1980

cctttaagaa agttgcaacc ataccgtata aggtttgcaa ctctgttaag gatactctgg     2040

cttattatgc tcacagcgtg ttgtacagag tttttcctta tgacatggat tctggtgtgt     2100

catcctttag tgaactactt tttgattgcg ttgatctttc agtagcttct acctattttt     2160

tagtccgcat cttgcaagat aagactggcg actttatgtc tacaattatt acttcctgcc     2220

aaactgctgt tagtaagctt ctagatacat gttttgaagc tacagaagca acatttaact     2280

tcttgttaga tttggcagga ttgttcagaa tctttctccg caatgcctat gtgtacactt     2340

cacaagggtt tgtggtggtc aatggcaaag tttctacact tgtcaaacaa gtgttagact     2400

tgcttaataa gggtatgcaa cttttgcata caaaggtctc ctgggctggt tctaaaatca     2460

ttgctgttat ctacagcggc agggagtctc taatattccc atcgggaacc tattactgtg     2520

tcaccactaa ggctaagtcc gttcaacaag atcttgacgt tattttgcct ggtgagtttt     2580

ccaagaagca gttaggactg ctccaaccta ctgacaattc tacaactgtt agtgttactg     2640

tatccagtaa catggttgaa actgttgtgg gtcaacttga gcaaactaat atgcatagtc     2700

ctgatgttat agtaggtgac tatgtcatta ttagtgaaaa attgtttgtg cgtagtaagg     2760

aagaagacgg atttgccttc taccctgctt gcactaatgg tcatgctgta ccgactctct     2820

ttagacttaa gggaggtgca cctgtaaaaa aagtagcctt tggcggtgat caagtacatg     2880

aggttgctgc tgtaagaagt gttactgtcg agtacaacat tcatgctgta ttagacacac     2940

tacttgcttc ttctagtctt agaacctttg ttgtagataa gtctttgtca attgaggagt     3000

ttgctgacgt agtaaaggaa caagtctcag acttgcttgt taaattactg cgtggaatgc     3060

cgattccaga ttttgattta gacgatttta ttgacgcacc atgctattgc tttaacgctg     3120

agggtgatgc atcctggtct tctactatga tcttctctct tcaccccgtc gagtgtgacg     3180

aggagtgttc tgaagtagag gcttcagatt tagaagaagg tgaatcagag tgcatttctg     3240

agacttcaac tgaacaagtt gacgtttctc atgagacttc tgacgacgag tgggctgctg     3300

cagttgatga agcgttccct ctcgatgaag cagaagatgt tactgaatct gtgcaagaag     3360

aagcacaacc agtagaagta cctgttgaag atattgcgca ggttgtcata gctgacacct     3420

tacaggaaac tcctgttgtg cctgatactg ttgaagtccc accgcaagtg gtgaaacttc     3480

cgtctgcacc tcagactatc cagcccgagg taaaagaagt tgcacctgtc tatgaggctg     3540

ataccgaaca gacacagaat gttactgtta aacctaagag gttacgcaaa aagcgtaatg     3600

ttgacccttt gtccaatttt gaacataagg ttattacaga gtgcgttacc atagttttag     3660

gtgacgcaat tcaagtagcc aagtgctatg gggagtctgt gttagttaat gctgctaaca     3720

cacatcttaa gcatggcggt ggtatcgctg gtgctattaa tgcggcttca aaaggggctg     3780

tccaaaaaga gtcagatgag tatattctgg ctaaagggcc gttacaagta ggagattcag     3840

ttctcttgca aggccattct ctagctaaga atatcctgca tgtcgtaggc ccagatgccc     3900

gcgctaaaca ggatgtttct ctccttagta agtgctataa ggctatgaat gcatatcctc     3960

ttgtagtcac tcctcttgtt tcagcaggca tatttggtgt aaaaccagct gtgtcttttg     4020

attatcttat tagggaggct aagactagag ttttagtcgt cgttaattcc caagatgtct     4080

ataagagtct taccatagtt gacattccac agagtttgac tttttcatat gatgggttac     4140

gtggcgcaat acgtaaagct aaagattatg gttttactgt ttttgtgtgc acagacaact     4200

ctgctaacac taaagttctt aggaacaagg gtgttgatta tactaagaag tttcttacag     4260

ttgacggtgt gcaatattat tgctacacgt ctaaggacac tttagatgat atcttacaac     4320

aggctaataa gtctgttggt attatatcta tgcctttggg atatgtgtct catggtttag     4380

acttaatgca agcagggagt gtcgtgcgta gagttaacgt gccctacgtg tgtctcctag     4440

ctaataaaga gcaagaagct attttgatgt ctgaagacgt taagttaaac ccttcagaag     4500

attttataaa gcacgtccgc actaatggtg gttacaattc ttggcattta gtcgagggtg     4560

aactattggt gcaagactta cgcttaaata agctcctgca ttggtctgat caaaccatat     4620

gctacaagga tagtgtgttt tatgttgtaa agaatagtac agcttttcca tttgaaacac     4680

tttcagcatg tcgtgcgtat ttggattcac gcacgacaca gcagttaaca atcgaagtct     4740

tagtgactgt cgatggtgta aattttagaa cagtcgttct aaataataag aacacttata     4800

gatcacagct tggatgcgtt ttctttaatg gtgctgatat ttctgacacc attcctgatg     4860

agaaacagaa tggtcacagt ttatatctag cagacaattt gactgctgat gaaacaaagg     4920

cgcttaaaga gttatatggc cccgttgatc ctactttctt acacagattc tattcactta     4980

aggctgcagt ccatgggtgg aagatggttg tgtgtgataa ggtacgttct ctcaaattga     5040

gtgataataa ttgttatctt aatgcagtta ttatgacact tgatttattg aaggacatta     5100

aatttgttat acctgctcta cagcatgcat ttatgaaaca taagggcggt gattcaactg     5160

acttcatagc cctcattatg gcttatggca attgcacatt tggtgctcca gatgatgcct     5220

ctcggttact tcataccgtg cttgcaaagg ctgagttatg ctgttctgca cgcatggttt     5280

ggagagagtg gtgcaatgtc tgtggcataa aagatgttgt tctacaaggc ttaaaagctt     5340

gttgttacgt gggtgtgcaa actgttgaag atctgcgtgc tcgcatgaca tatgtatgcc     5400

agtgtggtgg tgaacgtcat cggcaattag tcgaacacac caccccctgg ttgctgctct     5460

caggcacacc aaatgaaaaa ttggtgacaa cctccacggc gcctgatttt gtagcattta     5520

atgtctttca gggcattgaa acggctgttg gccattatgt tcatgctcgc ctgaagggtg     5580

gtcttatttt aaagtttgac tctggcaccg ttagcaagac ttcagactgg aagtgcaagg     5640

tgacagatgt acttttcccc ggccaaaaat acagtagcga ttgtaatgtc gtacggtatt     5700

ctttggacgg taatttcaga acagaggttg atcccgacct atctgctttc tatgttaagg     5760

atggtaaata ctttacaagt gaaccacccg taacatattc accagctaca attttagctg     5820

gtagtgtcta cactaatagc tgccttgtat cgtctgatgg acaacctggc ggtgatgcta     5880

ttagtttgag ttttaataac cttttagggt ttgattctag taaaccagtc actaagaaat     5940

acacttactc cttcttgcct aaagaagacg gcgatgtgtt gttggctgag tttgacactt     6000

atgaccctat ttataagaat ggtgccatgt ataaaggcaa accaattctt tgggtcaata     6060

aagcatctta tgatactaat cttaataagt tcaatagagc tagtttgcgt caaatttttg     6120

acgtagcccc cattgaactc gaaaataaat tcacaccttt gagtgtggag tctacaccag     6180

ttgaacctcc aactgtagat gtggtagcac ttcaacagga aatgacaatt gtcaaatgta     6240

agggtttaaa taaacctttc gtgaaggaca atgtcagttt cgttgctgat gattcaggta     6300

ctcccgttgt tgagtatctg tctaaagaag acctacatac attgtatgta gaccctaagt     6360

atcaagtcat tgtcttaaaa gacaatgtac tttcttctat gcttagattg cacaccgttg     6420

agtcaggtga tattaacgtt gttgcagctt ccggatcttt gacacgtaaa gtgaagttac     6480

tatttagggc ttcattttat ttcaaagaat ttgctacccg cactttcact gctaccactg     6540

ctgtaggtag ttgtataaag agtgtagtgc ggcatctagg tgttactaaa ggcatattga     6600

caggctgttt tagttttgcc aagatgttat ttatgcttcc actagcttac tttagtgatt     6660

caaaactcgg caccacagag gttaaagtga gtgctttgaa aacagccggc gttgtgacag     6720

gtaatgttgt aaaacagtgt tgcactgctg ctgttgattt aagtatggat aagttgcgcc     6780

gtgtggattg gaaatcaacc ctacggttgt tacttatgtt atgcacaact atggtattgt     6840

tgtcttctgt gtatcacttg tatgtcttca atcaggtctt atcaagtgat gttatgtttg     6900

aagatgccca aggtttgaaa aagttctaca aagaagttag agcttaccta ggaatctctt     6960

ctgcttgtga cggtcttgct tcagcttata gggcgaattc ctttgatgta cctacattct     7020

gcgcaaaccg ttctgcaatg tgtaattggt gcttgattag ccaagattcc ataactcact     7080

acccagctct taagatggtt caaacacatc ttagccacta tgttcttaac atagattggt     7140

tgtggtttgc atttgagact ggtttggcat acatgctcta tacctcggcc ttcaactggt     7200

tgttgttggc aggtacattg cattatttct ttgcacagac ttccatattt gtagactggc     7260

ggtcatacaa ttatgctgtg tctagtgcct tctggttatt cacccacatt ccaatggcgg     7320

gtttggtacg aatgtataat ttgttagcat gcctttggct tttacgcaag ttttatcagc     7380

atgtaatcaa tggttgcaaa gatacggcat gcttgctctg ctataagagg aaccgactta     7440

ctagagttga agcttctacc gttgtctgtg gtggaaaacg tacgttttat atcacagcaa     7500

atggcggtat ttcattctgt cgtaggcata attggaattg tgtggattgt gacactgcag     7560

gtgtggggaa taccttcatc tgtgaagaag tcgcaaatga cctcactacc gccctacgca     7620

ggcctattaa cgctacggat agatcacatt attatgtgga ttccgttaca gttaaagaga     7680

ctgttgttca gtttaattat cgtagagacg gtcaaccatt ctacgagcgg tttcccctct     7740

gcgcttttac aaatctagat aagttgaagt tcaaagaggt ctgtaaaact actactggta     7800

tacctgaata caactttatc atctacgact catcagatcg tggccaggaa agtttagcta     7860

ggtctgcatg tgtttattat tctcaagtct tgtgtaaatc aattcttttg gttgactcaa     7920

gtttggttac ttctgttggt gattctagtg aaatcgccac taaaatgttt gattcctttg     7980

ttaatagttt cgtctcgctg tataatgtca cacgcgataa gttggaaaaa cttatctcta     8040

ctgctcgtga tggcgtaagg cgaggcgata acttccatag tgtcttaaca acattcattg     8100

acgcagcacg aggccccgca ggtgtggagt ctgatgttga gaccaatgaa attgttgact     8160

ctgtgcagta tgctcataaa catgacatac aaattactaa tgagagctac aataattatg     8220

taccctcata tgttaaacct gatagtgtgt ctaccagcga tttaggtagt ctcattgatt     8280

gtaatgcggc ttcagttaac caaattgtct tgcgtaattc taatggtgct tgcatttgga     8340

acgctgctgc atatatgaaa ctctcggatg cacttaaacg acagattcgc attgcatgcc     8400

gtaagtgtaa tttagctttc cggttaacca cctcaaagct acgcgctaat gataatatct     8460

tatcagttag attcactgct aacaaaattg ttggtggtgc tcctacatgg tttaatgcgt     8520

tgcgtgactt tacgttaaag ggttatgttc ttgctaccat tattgtgttt ctgtgtgctg     8580

tactgatgta tttgtgttta cctacatttt ctatggcacc tgttgaattt tatgaagacc     8640

gcatcttgga ctttaaagtt cttgataatg gtatcattag ggatgtaaat cctgatgata     8700

agtgctttgc taataagcac cggtccttca cacaatggta tcatgagcat gttggtggtg     8760

tctatgacaa ctctatcaca tgcccattga cagttgcagt aattgctgga gttgctggtg     8820

ctcgcattcc agacgtacct actacattgg cttgggtgaa caatcagata attttctttg     8880

tttctcgagt ctttgctaat acaggcagtg tttgctacac tcctatagat gagataccct     8940

ataagagttt ctctgatagt ggttgcattc ttccatctga gtgcactatg tttagggatg     9000

cagagggccg tatgacacca tactgccatg atcctactgt tttgcctggg gcttttgcgt     9060

acagtcagat gaggcctcat gttcgttacg acttgtatga tggtaacatg tttattaaat     9120

ttcctgaagt agtatttgaa agtacactta ggattactag aactctgtca actcagtact     9180

gccggttcgg tagttgtgag tatgcacaag agggtgtttg tattaccaca aatggctcgt     9240

gggccatttt taatgaccac catcttaata gacctggtgt ctattgtggc tctgatttta     9300

ttgacattgt caggcggtta gcagtatcac tgttccagcc tattacttat ttccaattga     9360

ctacctcatt ggtcttgggt ataggtttgt gtgcgttcct gactttgctc ttctattata     9420

ttaataaagt aaaacgtgct tttgcagatt acacccagtg tgctgtaatt gctgttgttg     9480

ctgctgttct taatagcttg tgcatctgct ttgttacctc tataccattg tgtatagtac     9540

cttacactgc attgtactat tatgctacat tctattttac taatgagcct gcatttatta     9600

tgcatgtttc ttggtacatt atgttcgggc ctatcgttcc catatggatg acctgcgtct     9660

atacagttgc aatgtgcttt agacacttct tctgggtttt agcttatttt agtaagaaac     9720

atgtagaagt ttttactgat ggtaagctta attgtagttt ccaggacgct gcctctaata     9780

tctttgttat taacaaggac acttatgcag ctcttagaaa ctctttaact aatgatgcct     9840

attcacgatt tttggggttg tttaacaagt ataagtactt ctctggtgct atggaaacag     9900

ccgcttatcg tgaagctgca gcatgtcatc ttgctaaagc cttacaaaca tacagcgaga     9960

ctggtagtga tcttctttac caaccaccca actgtagcat aacctctggc gtgttgcaaa    10020

gcggtttggt gaaaatgtca catcccagtg gagatgttga ggcttgtatg gttcaggtta    10080

cctgcggtag catgactctt aatggtcttt ggcttgacaa cacagtctgg tgcccacgac    10140

acgtaatgtg cccggctgac cagttgtctg atcctaatta tgatgccttg ttgatttcta    10200

tgactaatca tagtttcagt gtgcaaaaac acattggcgc tccagcaaac ttgcgtgttg    10260

ttggtcatgc catgcaaggc actcttttga agttgactgt cgatgttgct aaccctagca    10320

ctccagccta cacttttaca acagtgaaac ctggcgcagc atttagtgtg ttagcatgct    10380

ataatggtcg tccgactggt acattcactg ttgtaatgcg ccctaactac acaattaagg    10440

gttcctttct gtgtggttct tgtggtagtg ttggttacac caaggagggt agtgtgatca    10500

atttctgtta catgcatcaa atggaacttg ctaatggtac acataccggt tcagcatttg    10560

atggtactat gtatggtgcc tttatggata aacaagtgca ccaagttcag ttaacagaca    10620

aatactgcag tgttaatgta gtagcttggc tttacgcagc aatacttaat ggttgcgctt    10680

ggtttgtaaa acctaatcgc actagtgttg tttcttttaa tgaatgggct cttgccaacc    10740

aattcactga atttgttggc actcaatccg ttgacatgtt agctgtcaaa acaggcgttg    10800

ctattgaaca gctgctttat gcgatccaac aactgtatac tgggttccag ggaaagcaaa    10860

tccttggcag taccatgttg gaagatgaat tcacacctga ggatgttaat atgcagatta    10920

tgggtgtggt tatgcagagt ggtgtgagaa aagttacata tggtactgcg cattggttgt    10980

ttgcgaccct tgtctcaacc tatgtgataa tcttacaagc cactaaattt actttgtgga    11040

actacttgtt tgagactatt cccacacagt tgttcccact cttatttgtg actatggcct    11100

tcgttatgtt gttggttaaa cacaaacaca cctttttgac acttttcttg ttgcctgtgg    11160

ctatttgttt gacttatgca aacatagtct acgagcccac tactcccatt tcgtcagcgc    11220

tgattgcagt tgcaaattgg cttgccccca ctaatgctta tatgcgcact acacatactg    11280

atattggtgt ctacattagt atgtcacttg tattagtcat tgtagtgaag agattgtaca    11340

acccatcact ttctaacttt gcgttagcat tgtgcagtgg tgtaatgtgg ttgtacactt    11400

atagcattgg agaagcctca agccccattg cctatctggt ttttgtcact acactcacta    11460

gtgattatac gattacagtc tttgttactg tcaaccttgc aaaagtttgc acttatgcca    11520

tctttgctta ctcaccacag cttacacttg tgtttccgga agtgaagatg atacttttat    11580

tatacacatg tttaggtttc atgtgtactt gctattttgg tgtcttctct cttttgaacc    11640

ttaagcttag agcacctatg ggtgtctatg actttaaggt ctcaacacaa gagttcagat    11700

tcatgactgc taacaatcta actgcaccta gaaattcttg ggaggctatg gctctgaact    11760

ttaagttaat aggtattggc ggtacacctt gtataaaggt tgctgctatg cagtctaaac    11820

ttacagatct taaatgcaca tctgtggttc tcctctctgt gctccaacag ttacacttag    11880

aggctaatag tagggcctgg gctttctgtg ttaaatgcca taatgatata ttggcagcaa    11940

cagaccccag tgaggctttc gagaaattcg taagtctctt tgctacttta atgacttttt    12000

ctggtaatgt agatcttgat gcgttagcta gtgatatttt tgacactcct agcgtacttc    12060

aagctactct ttctgagttt tcacacttag ctacctttgc tgagttggaa gctgcgcaga    12120

aagcctatca ggaagctatg gactctggtg acacctcacc acaagttctt aaggctttgc    12180

agaaggctgt taatatagct aaaaacgcct atgagaagga taaggcagtg gcccgtaagt    12240

tagaacgtat ggctgatcag gctatgactt ctatgtataa gcaagcacgt gctgaagaca    12300

agaaagcaaa aattgtcagt gctatgcaaa ctatgttgtt tggtatgatt aagaagctcg    12360

acaacgatgt tcttaatggt atcatttcta acgctaggaa tggttgtata cctcttagtg    12420

tcatcccact gtgtgcttca aataaacttc gcgttgtaat tcctgacttc accgtctgga    12480

atcaggtagt cacatatccc tcgcttaact acgctggggc tttgtgggac attacagtta    12540

taaacaatgt ggacaatgaa attgttaagt cttcagatgt tgtagacagc aatgaaaatt    12600

taacatggcc acttgtttta gaatgcacta gggcatccac ttctgccgtt aagttgcaaa    12660

ataatgagat caaaccttca ggtctaaaaa ccatggttgt gtctgcgggt caagagcaaa    12720

ctaactgtaa tactagttcc ttagcttatt acgaacctgt gcagggtcgt aaaatgctga    12780

tggctcttct ttctgataat gcctatctca aatgggcgcg tgttgaaggt aaggacggat    12840

ttgtcagtgt agagctacaa cctccttgca aattcttgat tgcgggacca aaaggacctg    12900

aaatccgata tctctatttt gttaaaaatc ttaacaacct tcatcgcggg caagtgttag    12960

ggcacattgc tgcgactgtt agattgcaag ctggttctaa caccgagttt gcctctaatt    13020

cctcggtgtt gtcacttgtt aacttcaccg ttgatcctca aaaagcttat ctcgatttcg    13080

tcaatgcggg aggtgcccca ttgacaaatt gtgttaagat gcttactcct aaaactggta    13140

caggtatagc tatatctgtt aaaccagaga gtacagctga tcaagagact tatggtggag    13200

cttcagtgtg tctctattgc cgtgcgcata tagaacatcc tgatgtctct ggtgtttgta    13260

aatataaggg taagtttgtc caaatccctg ctcagtgtgt ccgtgaccct gtgggatttt    13320

gtttgtcaaa taccccctgt aatgtctgtc aatattggat tggatatggg tgcaattgtg    13380

actcgcttag gcaagcagca ctgccccaat ctaaagattc caatttttta aacgagtccg    13440

gggttctatt gtaaatgccc gaatagaacc ctgttcaagt ggtttgtcca ctgatgtcgt    13500

ctttagggca tttgacatct gcaactataa ggctaaggtt gctggtattg gaaaatacta    13560

caagactaat acttgtaggt ttgtagaatt agatgaccaa gggcatcatt tagactccta    13620

ttttgtcgtt aagaggcata ctatggagaa ttatgaacta gagaagcact gttacgactt    13680

gttacgtgac tgtgatgctg tagctcccca tgatttcttc atctttgatg tagacaaagt    13740

taaaacacct catattgtac gtcagcgttt aactgagtac actatgatgg atcttgtata    13800

tgccctgagg cactttgatc aaaatagcga agtgcttaag gctatcttag tgaagtatgg    13860

ttgctgtgat gttacctact ttgaaaataa actctggttt gattttgttg aaaatcccag    13920

tgttattggt gtttatcata aacttggaga acgtgtacgc caagctatct taaacactgt    13980

taaattttgt gaccacatgg tcaaggctgg tttagtcggt gtgctcacac tagacaacca    14040

ggaccttaat ggcaagtggt atgattttgg tgacttcgta atcactcaac ctggttcagg    14100

agtagctata gttgatagct actattctta tttgatgcct gtgctctcaa tgaccgattg    14160

tctggccgct gagacacata gggattgtga ttttaataaa ccactcattg agtggccact    14220

tactgagtat gattttactg attataaggt acaactcttt gagaagtact ttaaatattg    14280

ggatcagacg tatcacgcaa attgcgttaa ttgtactgat gaccgttgtg tgttacattg    14340

tgctaatttc aatgtattgt ttgctatgac catgcctaag acttgtttcg gacccatagt    14400

ccgaaagatc tttgttgatg gcgtgccatt tgtagtatct tgtggttatc actacaaaga    14460

attaggttta gtcatgaata tggatgttag tctccataga cataggctct ctcttaagga    14520

gttgatgatg tatgccgctg atccagccat gcacattgcc tcctctaacg cttttcttga    14580

tttgaggaca tcatgtttta gtgtcgctgc acttacaact ggtttgactt ttcaaactgt    14640

gcggcctggc aattttaacc aagacttcta tgatttcgtg gtatctaaag gtttctttaa    14700

ggagggctct tcagtgacgc tcaaacattt tttctttgct caagatggta atgctgctat    14760

tacagattat aattactatt cttataatct gcctactatg tgtgacatca aacaaatgtt    14820

gttctgcatg gaagttgtaa acaagtactt cgaaatctat gacggtggtt gtcttaatgc    14880

ttctgaagtg gttgttaata atttagacaa gagtgctggc catcctttta ataagtttgg    14940

caaagctcgt gtctattatg agagcatgtc ttaccaggag caagatgaac tttttgccat    15000

gacaaagcgt aacgtcattc ctaccatgac tcaaatgaat ctaaaatatg ctattagtgc    15060

taagaataga gctcgcactg ttgcaggcgt gtccatactt agcacaatga ctaatcgcca    15120

gtaccatcag aaaatgctta agtccatggc tgcaactcgt ggagcgactt gcgtcattgg    15180

tactacaaag ttctacggtg gctgggattt catgcttaaa acattgtaca aagatgttga    15240

taatccgcat cttatgggtt gggattaccc taagtgtgat agagctatgc ctaatatgtg    15300

tagaatcttc gcttcactca tattagctcg taaacatggc acttgttgta ctacaaggga    15360

cagattttat cgcttggcaa atgagtgtgc tcaggtgcta agcgaatatg ttctatgtgg    15420

tggtggttac tacgtcaaac ctggaggtac cagtagcgga gatgccacca ctgcatatgc    15480

caatagtgtc tttaacattt tgcaggcgac aactgctaat gtcagtgcac ttatgggtgc    15540

taatggcaac aagattgttg acaaagaagt taaagacatg cagtttgatt tgtatgtcaa    15600

tgtttacagg agcactagcc cagaccccaa atttgttgat aaatactatg cttttcttaa    15660

taagcacttt tctatgatga tactgtctga tgacggtgtc gtttgctata atagtgatta    15720

tgcagctaag ggttacattg ctggaataca gaattttaag gaaacgctgt attatcagaa    15780

caatgtcttt atgtctgaag ctaaatgctg ggtggaaacc gatctgaaga aagggccaca    15840

tgaattctgt tcacagcata cgctttatat taaggatggc gacgatggtt acttccttcc    15900

ttatccagac ccttcaagaa ttttgtctgc cggttgcttt gtagatgata tcgttaagac    15960

tgacggtaca ctcatggtag agcggtttgt gtctttggct atagatgctt accctctcac    16020

aaagcatgaa gatatagaat accagaatgt attctgggtc tacttacagt atatagaaaa    16080

actgtataaa gaccttacag gacacatgct tgacagttat tctgtcatgc tatgtggtga    16140

taattctgct aagttttggg aagaggcatt ctatagagat ctctatagtt cgcctaccac    16200

tttgcaggct gtcggttcat gcgttgtatg ccattcacag acttccctac gctgtgggac    16260

atgcatccgt agaccatttc tctgctgtaa atgctgctat gatcatgtta tagcaactcc    16320

acataagatg gttttgtctg tttctcctta cgtttgtaat gcccctggtt gtggcgtttc    16380

agacgttact aagctatatt taggtggtat gagctacttt tgtgtagatc atagacctgt    16440

gtgtagtttt ccactttgcg ctaatggtct tgtattcggc ttatacaaga atatgtgcac    16500

aggtagtcct tctatagttg aatttaatag gttggctacc tgtgactgga ctgaaagtgg    16560

tgattacacc cttgccaata ctacaacaga accactcaaa ctttttgctg ctgagacttt    16620

acgtgccact gaagaggcgt ctaagcagtc ttatgctatt gccaccatca aagaaattgt    16680

tggtgagcgc caactattac ttgtgtggga ggctggcaag tccaaaccac cactcaatcg    16740

taattatgtt tttactggtt atcatataac caaaaatagt aaagtgcagc tcggtgagta    16800

cattttcgag cgcattgatt atagtgatgc tgtatcctac aagtctagta caacgtataa    16860

actgactgta ggtgacatct tcgtacttac ctctcactct gtggctacct tgacggcgcc    16920

cacaattgtg aatcaagaga ggtatgttaa aattactggg ttgtacccaa ccattacggt    16980

acctgaagag ttcgcaagtc atgttgccaa cttccaaaaa tcaggttata gtaaatatgt    17040

cactgttcag ggaccacctg gcactggcaa aagtcatttt gctatagggt tagcgattta    17100

ctaccctaca gcacgtgttg tttatacagc atgttcacac gcagctgttg atgctttgtg    17160

tgaaaaagct tttaaatatt tgaacattgc taaatgttcc cgtatcattc ctgcaaaggc    17220

acgtgttgag tgctatgaca ggtttaaagt taatgagaca aattctcaat atttgtttag    17280

tactattaat gctctaccag aaacttctgc cgatattctg gtggttgatg aggttagtat    17340

gtgcactaat tatgatcttt caattattaa tgcacgtatt aaagctaagc acattgtcta    17400

tgtaggagat ccagcacagt tgccagctcc taggactttg ttgactagag gcacattgga    17460

accagaaaat ttcaatagtg tcactagatt gatgtgtaac ttaggtcctg acatattttt    17520

aagtatgtgc tacaggtgtc ctaaggaaat agtaagcact gtgagcgctc ttgtctacaa    17580

taataaattg ttagccaaga aggagctttc aggccagtgc tttaaaatac tctataaggg    17640

caatgtgacg catgatgcta gctctgccat taatagacca caactcacat ttgtgaagaa    17700

ttttattact gccaatccgg catggagtaa ggcagtcttt atttcgcctt acaattcaca    17760

gaatgctgtg tctcgttcaa tgctgggtct taccactcag actgttgatt cctcacaggg    17820

ttcagaatac cagtacgtta tcttctgtca aacagcagat acggcacatg ctaacaacat    17880

taacagattt aatgttgcaa tcactcgtgc ccaaaaaggt attctttgtg ttatgacatc    17940

tcaggcactc tttgagtcct tagagtttac tgaattgtct tttactaatt acaagctcca    18000

gtctcagatt gtaactggcc tttttaaaga ttgctctaga gaaacttctg gcctctcacc    18060

tgcttatgca ccaacatatg ttagtgttga tgacaagtat aagacgagtg atgagctttg    18120

cgtgaatctt aatttacccg caaatgtccc atactctcgt gttatttcca ggatgggctt    18180

taaactcgat gcaacagttc ctggatatcc taagcttttc attactcgtg aagaggctgt    18240

aaggcaagtt cgaagctgga taggcttcga tgttgagggt gctcatgctt cccgtaatgc    18300

atgtggcacc aatgtgcctc tacaattagg attttcaact ggtgtgaact ttgttgttca    18360

gccagttggt gttgtagaca ctgagtgggg taacatgtta acgggcattg ctgcacgtcc    18420

tccaccaggt gaacagttta agcacctcgt gcctcttatg cataaggggg ctgcgtggcc    18480

tattgttaga cgacgtatag tgcaaatgtt gtcagacact ttagacaaat tgtctgatta    18540

ctgtacgttt gtttgttggg ctcatggctt tgaattaacg tctgcatcat acttttgcaa    18600

gataggtaag gaacagaagt gttgcatgtg caatagacgc gctgcagcgt actcttcacc    18660

tctgcaatct tatgcctgct ggactcattc ctgcggttat gattatgtct acaacccttt    18720

ctttgtcgat gttcaacagt ggggttatgt aggcaatctt gctactaatc acgatcgtta    18780

ttgctctgtc catcaaggag ctcatgtggc ttctaatgat gcaataatga ctcgttgttt    18840

agctattcat tcttgtttta tagaacgtgt ggattgggat atagagtatc cttatatctc    18900

acatgaaaag aaattgaatt cctgttgtag aatcgttgag cgcaacgtcg tacgtgctgc    18960

tcttcttgcc ggttcatttg acaaagtcta tgatattggc aatcctaaag gaattcctat    19020

tgttgatgac cctgtggttg attggcatta ttttgatgca cagcccttga ccaggaaggt    19080

acaacagctt ttctatacag aggacatggc ctcaagattt gctgatgggc tctgcttatt    19140

ttggaactgt aatgtaccaa aatatcctaa taatgcaatt gtatgcaggt ttgacacacg    19200

tgtgcattct gagttcaatt tgccaggttg tgatggcggt agtttgtatg ttaacaagca    19260

cgcttttcat acaccagcat atgatgtgag tgcattccgt gatctgaaac ctttaccatt    19320

cttttattat tctactacac catgtgaagt gcatggtaat ggtagtatga tagaggatat    19380

tgattatgta cccctaaaat ctgcagtctg tattacagct tgtaatttag ggggcgctgt    19440

ttgtaggaag catgctacag agtacagaga gtatatggaa gcatataatc ttgtctctgc    19500

atcaggtttc cgcctttggt gttataagac ctttgatatt tataatctct ggtctacttt    19560

tacaaaagtt caaggtttgg aaaacattgc ttttaatgtt gttaaacaag gccattttat    19620

tggtgttgag ggtgaactac ctgtagctgt agtcaatgat aagatcttca ccaagagtgg    19680

cgttaatgac atttgtatgt ttgagaataa aaccactttg cctactaata tagcttttga    19740

actctatgct aagcgtgctg tacgctcgca tcccgatttc aaattgctac acaatttaca    19800

agcagacatt tgctacaagt tcgtcctttg ggattatgaa cgtagcaata tttatggtac    19860

tgctactatt ggtgtatgta agtacactga tattgatgtt aattcagctt tgaatatatg    19920

ttttgacata cgcgataatt gttcattgga gaagttcatg tctactccca atgccatctt    19980

tatttctgat agaaaaatca agaaataccc ttgtatggta ggtcctgatt atgcttactt    20040

caatggtgct atcatccgtg atagtgatgt tgttaaacaa ccagtgaagt tctacttgta    20100

taagaaagtc aataatgagt ttattgatcc tactgagtgt atttacactc agagtcgctc    20160

ttgtagtgac ttcctacccc tttctgacat ggagaaagac tttctatctt ttgatagtga    20220

tgttttcatt aagaagtatg gcttggaaaa ctatgctttt gagcacgtag tctatggaga    20280

cttctctcat actacgttag gcggtcttca cttgcttatt ggtttataca agaagcaaca    20340

ggaaggtcat attattatgg aagaaatgct aaaaggtagc tcaactattc ataactattt    20400

tattactgag actaacacag cggcttttaa ggcggtgtgt tctgttatag atttaaagct    20460

tgacgacttt gttatgattt taaagagtca agaccttggc gtagtatcca aggttgtcaa    20520

ggttcctatt gacttaacaa tgattgagtt tatgttatgg tgtaaggatg gacaggttca    20580

aaccttctac cctcgactcc aggcttctgc agattggaaa cctggtcatg caatgccatc    20640

cctctttaaa gttcaaaatg taaaccttga acgttgtgag cttgctaatt acaagcaatc    20700

tattcctatg cctcgcggtg tgcacatgaa catcgctaaa tatatgcaat tgtgccagta    20760

tttaaatact tgcacattag ccgtgcctgc caatatgcgt gttatacatt ttggcgctgg    20820

ttctgataaa ggtatcgctc ctggtacctc agttttacga cagtggcttc ctacagatgc    20880

cattattata gataatgatt taaatgagtt cgtgtcagat gctgacataa ctttatttgg    20940

agattgtgta actgtacgtg tcggccaaca agtggatctt gttatttccg acatgtatga    21000

tcctactact aagaatgtaa caggtagtaa tgagtcaaag gctttattct ttacttacct    21060

gtgtaacctc attaataata atcttgctct tggtgggtct gttgctatta aaataacaga    21120

acactcttgg agcgttgaac tttatgaact tatgggaaaa tttgcttggt ggactgtttt    21180

ctgcaccaat gcaaatgcat cctcatctga aggattcctc ttaggtatta attacttggg    21240

tactattaaa gaaaatatag atggtggtgc tatgcacgcc aactatatat tttggagaaa    21300

ttccactcct atgaatctga gtacttactc actttttgat ttatccaagt ttcaattaaa    21360

attaaaagga acaccagttc ttcaattaaa ggagagtcaa attaacgaac tcgtaatatc    21420

tctcctgtcg cagggtaagt tacttatccg tgacaatgat acactcagtg tttctactga    21480

tgttcttgtt aacacctaca gaaagttacg ttgatgtagg gccagattct gttaagtctg    21540

cttgtattga ggttgatata caacagactt tctttgataa aacttggcct aggccaattg    21600

atgtttctaa ggctgacggt attatatacc ctcaaggccg tacatattct aacataacta    21660

tcacttatca aggtcttttt ccctatcagg gagaccatgg tgatatgtat gtttactctg    21720

caggacatgc tacaggcaca actccacaaa agttgtttgt agctaactat tctcaggacg    21780

tcaaacagtt tgctaatggg tttgtcgtcc gtataggagc agctgccaat tccactggca    21840

ctgttattat tagcccatct accagcgcta ctatacgaaa aatttaccct gcttttatgc    21900

tgggttcttc agttggtaat ttctcagatg gtaaaatggg ccgcttcttc aatcatactc    21960

tagttctttt gcccgatgga tgtggcactt tacttagagc tttttattgt attctagagc    22020

ctcgctctgg aaatcattgt cctgctggca attcctatac ttcttttgcc acttatcaca    22080

ctcctgcaac agattgttct gatggcaatt acaatcgtaa tgccagtctg aactctttta    22140

aggagtattt taatttacgt aactgcacct ttatgtacac ttataacatt accgaagatg    22200

agattttaga gtggtttggc attacacaaa ctgctcaagg tgttcacctc ttctcatctc    22260

ggtatgttga tttgtacggc ggcaatatgt ttcaatttgc caccttgcct gtttatgata    22320

ctattaagta ttattctatc attcctcaca gtattcgttc tatccaaagt gatagaaaag    22380

cttgggctgc cttctacgta tataaacttc aaccgttaac tttcctgttg gatttttctg    22440

ttgatggtta tatacgcaga gctatagact gtggttttaa tgatttgtca caactccact    22500

gctcatatga atccttcgat gttgaatctg gagtttattc agtttcgtct ttcgaagcaa    22560

aaccttctgg ctcagttgtg gaacaggctg aaggtgttga atgtgatttt tcacctcttc    22620

tgtctggcac acctcctcag gtttataatt tcaagcgttt ggtttttacc aattgcaatt    22680

ataatcttac caaattgctt tcactttttt ctgtgaatga ttttacttgt agtcaaatat    22740

ctccagcagc aattgctagc aactgttatt cttcactgat tttggattac ttttcatacc    22800

cacttagtat gaaatccgat ctcagtgtta gttctgctgg tccaatatcc cagtttaatt    22860

ataaacagtc cttttctaat cccacatgtt tgattttagc gactgttcct cataacctta    22920

ctactattac taagcctctt aagtacagct atattaacaa gtgctctcgt cttctttctg    22980

atgatcgtac tgaagtacct cagttagtga acgctaatca atactcaccc tgtgtatcca    23040

ttgtcccatc cactgtgtgg gaagacggtg attattatag gaaacaacta tctccacttg    23100

aaggtggtgg ctggcttgtt gctagtggct caactgttgc catgactgag caattacaga    23160

tgggctttgg tattacagtt caatatggta cagacaccaa tagtgtttgc cccaagcttg    23220

aatttgctaa tgacacaaaa attgcctctc aattaggcaa ttgcgtggaa tattccctct    23280

atggtgtttc gggccgtggt gtttttcaga attgcacagc tgtaggtgtt cgacagcagc    23340

gctttgttta tgatgcgtac cagaatttag ttggctatta ttctgatgat ggcaactact    23400

actgtttgcg tgcttgtgtt agtgttcctg tttctgtcat ctatgataaa gaaactaaaa    23460

cccacgctac tctatttggt agtgttgcat gtgaacacat ttcttctacc atgtctcaat    23520

actcccgttc tacgcgatca atgcttaaac ggcgagattc tacatatggc ccccttcaga    23580

cacctgttgg ttgtgtccta ggacttgtta attcctcttt gttcgtagag gactgcaagt    23640

tgcctcttgg tcaatctctc tgtgctcttc ctgacacacc tagtactctc acacctcgca    23700

gtgtgcgctc tgttccaggt gaaatgcgct tggcatccat tgcttttaat catcctattc    23760

aggttgatca acttaatagt agttatttta aattaagtat acccactaat ttttcctttg    23820

gtgtgactca ggagtacatt cagacaacca ttcagaaagt tactgttgat tgtaaacagt    23880

acgtttgcaa tggtttccag aagtgtgagc aattactgcg cgagtatggc cagttttgtt    23940

ccaaaataaa ccaggctctc catggtgcca atttacgcca ggatgattct gtacgtaatt    24000

tgtttgcgag cgtgaaaagc tctcaatcat ctcctatcat accaggtttt ggaggtgact    24060

ttaatttgac acttctagaa cctgtttcta tatctactgg cagtcgtagt gcacgtagtg    24120

ctattgagga tttgctattt gacaaagtca ctatagctga tcctggttat atgcaaggtt    24180

acgatgattg catgcagcaa ggtccagcat cagctcgtga tcttatttgt gctcaatatg    24240

tggctggtta caaagtatta cctcctctta tggatgttaa tatggaagcc gcgtatactt    24300

catctttgct tggcagcata gcaggtgttg gctggactgc tggcttatcc tcctttgctg    24360

ctattccatt tgcacagagt atcttttata ggttaaacgg tgttggcatt actcaacagg    24420

ttctttcaga gaaccaaaag cttattgcca ataagtttaa tcaggctctg ggagctatgc    24480

aaacaggctt cactacaact aatgaagctt ttcagaaggt tcaggatgct gtgaacaaca    24540

atgcacaggc tctatccaaa ttagctagcg agctatctaa tacttttggt gctatttccg    24600

cctctattgg agacatcata caacgtcttg atgttctcga acaggacgcc caaatagaca    24660

gacttattaa tggccgtttg acaacactaa atgcttttgt tgcacagcag cttgttcgtt    24720

ccgaatcagc tgctctttcc gctcaattgg ctaaagataa agtcaatgag tgtgtcaagg    24780

cacaatccaa gcgttctgga ttttgcggtc aaggcacaca tatagtgtcc tttgttgtaa    24840

atgcccctaa tggcctttac ttcatgcatg ttggttatta ccctagcaac cacattgagg    24900

ttgtttctgc ttatggtctt tgcgatgcag ctaaccctac taattgtata gcccctgtta    24960

atggctactt tattaaaact aataacacta ggattgttga tgagtggtca tatactggct    25020

cgtccttcta tgcacctgag cccattacct cccttaatac taagtatgtt gcaccacagg    25080

tgacatacca aaacatttct actaacctcc ctcctcctct tctcggcaat tccaccggga    25140

ttgacttcca agatgagttg gatgagtttt tcaaaaatgt tagcaccagt atacctaatt    25200

ttggttccct aacacagatt aatactacat tactcgatct tacctacgag atgttgtctc    25260

ttcaacaagt tgttaaagcc cttaatgagt cttacataga ccttaaagag cttggcaatt    25320

atacttatta caacaaatgg ccgtggtaca tttggcttgg tttcattgct gggcttgttg    25380

ccttagctct atgcgtcttc ttcatactgt gctgcactgg ttgtggcaca aactgtatgg    25440

gaaaacttaa gtgtaatcgt tgttgtgata gatacgagga atacgacctc gagccgcata    25500

aggttcatgt tcactaatta acgaactatt aatgagagtt caaagaccac ccactctctt    25560

gttagtgttt tcactctctc ttttggtcac tgcatcctca aaacctctct atgtacctga    25620

gcattgtcag aattattctg gttgcatgct tagggcttgt attaaaactg cccaagctga    25680

tacagctggt ctttatacaa attttcgaat tgacgtccca tctgcagaat caactggtac    25740

tcaatcagtt tctgtcgatc ttgagtcaac ttcaactcat gatggtccta ccgaacatgt    25800

tactagtgtg aatctttttg acgttggtta ctcagttaat taacgaactc tatggattac    25860

gtgtctctgc ttaatcaaat ttggcagaag taccttaact caccgtatac tacttgtttg    25920

tacatcccta aacccacagc taagtataca cctttagttg gcacttcatt gcaccctgtg    25980

ctgtggaact gtcagctatc ctttgctggt tatactgaat ctgctgttaa ttctacaaaa    26040

gctttggcca aacaggacgc agctcagcga atcgcttggt tgctacataa ggatggagga    26100

atccctgatg gatgttccct ctacctccgg cactcaagtt tattcgcgca aagcgaggaa    26160

gaggagccat tctccaacta agaaactgcg ctacgttaag cgtagatttt ctcttctgcg    26220

ccatgaagac cttagtgtta ttgtccaacc aacacactat gtcagggtta cattttcaga    26280

ccccaacatg tggtatctac gttcgggtca tcatttacac tcagttcaca attggcttaa    26340

accttatggc ggccaacctg tttctgagta ccatattact ctagctttgc taaatctcac    26400

tgatgaagat ttagctagag atttttcacc cattgcgctc tttttgcgca atgtcagatt    26460

tgagctacat gagttcgcct tgctgcgcaa aactcttgtt cttaatgcat cagagatcta    26520

ctgtgctaac atacatagat ttaagcctgt gtatagagtt aacacggcaa tccctactat    26580

taaggattgg cttctcgttc agggattttc cctttaccat agtggcctcc ctttacatat    26640

gtcaatctct aaattgcatg cactggatga tgttactcgc aattacatca ttacaatgcc    26700

atgctttaga acttaccctc aacaaatgtt tgttactcct ttggccgtag atgttgtctc    26760

catacggtct tccaatcagg gtaataaaca aattgttcat tcttatccca ttttacatca    26820

tccaggattt taacgaacta tggctttctc ggcgtcttta tttaaacccg tccagctagt    26880

cccagtttct cctgcatttc atcgcattga gtctactgac tctattgttt tcacatacat    26940

tcctgctagc ggctatgtag ctgctttagc tgtcaatgtg tgtctcattc ccctattatt    27000

actgctacgt caagatactt gtcgtcgcag cattatcaga actatggttc tctatttcct    27060

tgttctgtat aactttttat tagccattgt actagtcaat ggtgtacatt atccaactgg    27120

aagttgcctg atagccttct tagttatcct cataatactt tggtttgtag atagaattcg    27180

tttctgtctc atgctgaatt cctacattcc actgtttgac atgcgttccc actttattcg    27240

tgttagtaca gtttcttctc atggtatggt ccctgtaata cacaccaaac cattatttat    27300

tagaaacttc gatcagcgtt gcagctgttc tcgttgtttt tatttgcact cttccactta    27360

tatagagtgc acttatatta gccgttttag taagattagc ctagtttctg taactgactt    27420

ctccttaaac ggcaatgttt ccactgtttt cgtgcctgca acgcgcgatt cagttcctct    27480

tcacataatc gccccgagct cgcttatcgt ttaagcagct ctgcgctact atgggtcccg    27540

tgtagaggct aatccattag tctctctttg gacatatgga aaacgaacta tgttaccctt    27600

tgtccaagaa cgaatagggt tgttcatagt aaactttttc atttttaccg tagtatgtgc    27660

tataacactc ttggtgtgta tggctttcct tacggctact agattatgtg tgcaatgtat    27720

gacaggcttc aataccctgt tagttcagcc cgcattatac ttgtataata ctggacgttc    27780

agtctatgta aaattccagg atagtaaacc ccctctacca cctgacgagt gggtttaacg    27840

aactccttca taatgtctaa tatgacgcaa ctcactgagg cgcagattat tgccattatt    27900

aaagactgga actttgcatg gtccctgatc tttctcttaa ttactatcgt actacagtat    27960

ggatacccat cccgtagtat gactgtctat gtctttaaaa tgtttgtttt atggctccta    28020

tggccatctt ccatggcgct atcaatattt agcgccgttt atccaattga tctagcttcc    28080

cagataatct ctggcattgt agcagctgtt tcagctatga tgtggatttc ctactttgtg    28140

cagagtatcc ggctgtttat gagaactgga tcatggtggt cattcaatcc tgagactaat    28200

tgccttttga acgttccatt tggtggtaca actgtcgtac gtccactcgt agaggactct    28260

accagtgtaa ctgctgttgt aaccaatggc cacctcaaaa tggctggcat gcatttcggt    28320

gcttgtgact acgacagact tcctaatgaa gtcaccgtgg ccaaacccaa tgtgctgatt    28380

gctttaaaaa tggtgaagcg gcaaagctac ggaactaatt ccggcgttgc catttaccat    28440

agatataagg caggtaatta caggagtccg cctattacgg cggatattga acttgcattg    28500

cttcgagctt aggctcttta gtaagagtat cttaattgat tttaacgaat ctcaatttca    28560

ttgttatggc atcccctgct gcacctcgtg ctgtttcctt tgccgataac aatgatataa    28620

caaatacaaa cctatctcga ggtagaggac gtaatccaaa accacgagct gcaccaaata    28680

acactgtctc ttggtacact gggcttaccc aacacgggaa agtccctctt acctttccac    28740

ctgggcaggg tgtacctctt aatgccaatt ctacccctgc gcaaaatgct gggtattggc    28800

ggagacagga cagaaaaatt aataccggga atggaattaa gcaactggct cccaggtggt    28860

acttctacta cactggaact ggacccgaag cagcactccc attccgggct gttaaggatg    28920

gcatcgtttg ggtccatgaa gatggcgcca ctgatgctcc ttcaactttt gggacgcgga    28980

accctaacaa tgattcagct attgttacac aattcgcgcc cggtactaag cttcctaaaa    29040

acttccacat tgaggggact ggaggcaata gtcaatcatc ttcaagagcc tctagcttaa    29100

gcagaaactc ttccagatct agttcacaag gttcaagatc aggaaactct acccgcggca    29160

cttctccagg tccatctgga atcggagcag taggaggtga tctactttac cttgatcttc    29220

tgaacagact acaagccctt gagtctggca aagtaaagca atcgcagcca aaagtaatca    29280

ctaagaaaga tgctgctgct gctaaaaata agatgcgcca caagcgcact tccaccaaaa    29340

gtttcaacat ggtgcaagct tttggtcttc gcggaccagg agacctccag ggaaactttg    29400

gtgatcttca attgaataaa ctcggcactg aggacccacg ttggccccaa attgctgagc    29460

ttgctcctac agccagtgct tttatgggta tgtcgcaatt taaacttacc catcagaaca    29520

atgatgatca tggcaaccct gtgtacttcc ttcggtacag tggagccatt aaacttgacc    29580

caaagaatcc caactacaat aagtggttgg agcttcttga gcaaaatatt gatgcctaca    29640

aaaccttccc taagaaggaa aagaaacaaa aggcaccaaa agaagaatca acagaccaaa    29700

tgtctgaacc tccaaaggag cagcgtgtgc aaggtagcat cactcagcgc actcgcaccc    29760

gtccaagtgt tcagcctggt ccaatgattg atgttaacac tgattagtgt cactcaaagt    29820

aacaagatcg cggcaatcgt ttgtgtttgg caaccccatc tcaccatcgc ttgtccactc    29880

ttgcacagaa tggaatcatg ttgtaattac agtgcaataa ggtaattata acccatttaa    29940

ttgatagcta tgctttatta aagtgtgtag ctgtagagag aatgttaaag actgtcacct    30000

ctgcttgatt gcaagtgaac agtgcccccc gggaagagct ctacagtgtg aaatgtaaat    30060

aaaaaatagc tattattcaa ttagattagg ctaattagat gatttgcaaa aaaaaaaaa     30119


<210>  2
<211>  4062
<212>  DNA
<213>  Middle East Respiratory Syndrome Coronavirus

<400>  2
atgatacact cagtgtttct actgatgttc ttgttaacac ctacagaaag ttacgttgat       60

gtagggccag attctgttaa gtctgcttgt attgaggttg atatacaaca gactttcttt      120

gataaaactt ggcctaggcc aattgatgtt tctaaggctg acggtattat ataccctcaa      180

ggccgtacat attctaacat aactatcact tatcaaggtc tttttcccta tcagggagac      240

catggtgata tgtatgttta ctctgcagga catgctacag gcacaactcc acaaaagttg      300

tttgtagcta actattctca ggacgtcaaa cagtttgcta atgggtttgt cgtccgtata      360

ggagcagctg ccaattccac tggcactgtt attattagcc catctaccag cgctactata      420

cgaaaaattt accctgcttt tatgctgggt tcttcagttg gtaatttctc agatggtaaa      480

atgggccgct tcttcaatca tactctagtt cttttgcccg atggatgtgg cactttactt      540

agagcttttt attgtattct agagcctcgc tctggaaatc attgtcctgc tggcaattcc      600

tatacttctt ttgccactta tcacactcct gcaacagatt gttctgatgg caattacaat      660

cgtaatgcca gtctgaactc ttttaaggag tattttaatt tacgtaactg cacctttatg      720

tacacttata acattaccga agatgagatt ttagagtggt ttggcattac acaaactgct      780

caaggtgttc acctcttctc atctcggtat gttgatttgt acggcggcaa tatgtttcaa      840

tttgccacct tgcctgttta tgatactatt aagtattatt ctatcattcc tcacagtatt      900

cgttctatcc aaagtgatag aaaagcttgg gctgccttct acgtatataa acttcaaccg      960

ttaactttcc tgttggattt ttctgttgat ggttatatac gcagagctat agactgtggt     1020

tttaatgatt tgtcacaact ccactgctca tatgaatcct tcgatgttga atctggagtt     1080

tattcagttt cgtctttcga agcaaaacct tctggctcag ttgtggaaca ggctgaaggt     1140

gttgaatgtg atttttcacc tcttctgtct ggcacacctc ctcaggttta taatttcaag     1200

cgtttggttt ttaccaattg caattataat cttaccaaat tgctttcact tttttctgtg     1260

aatgatttta cttgtagtca aatatctcca gcagcaattg ctagcaactg ttattcttca     1320

ctgattttgg attacttttc atacccactt agtatgaaat ccgatctcag tgttagttct     1380

gctggtccaa tatcccagtt taattataaa cagtcctttt ctaatcccac atgtttgatt     1440

ttagcgactg ttcctcataa ccttactact attactaagc ctcttaagta cagctatatt     1500

aacaagtgct ctcgtcttct ttctgatgat cgtactgaag tacctcagtt agtgaacgct     1560

aatcaatact caccctgtgt atccattgtc ccatccactg tgtgggaaga cggtgattat     1620

tataggaaac aactatctcc acttgaaggt ggtggctggc ttgttgctag tggctcaact     1680

gttgccatga ctgagcaatt acagatgggc tttggtatta cagttcaata tggtacagac     1740

accaatagtg tttgccccaa gcttgaattt gctaatgaca caaaaattgc ctctcaatta     1800

ggcaattgcg tggaatattc cctctatggt gtttcgggcc gtggtgtttt tcagaattgc     1860

acagctgtag gtgttcgaca gcagcgcttt gtttatgatg cgtaccagaa tttagttggc     1920

tattattctg atgatggcaa ctactactgt ttgcgtgctt gtgttagtgt tcctgtttct     1980

gtcatctatg ataaagaaac taaaacccac gctactctat ttggtagtgt tgcatgtgaa     2040

cacatttctt ctaccatgtc tcaatactcc cgttctacgc gatcaatgct taaacggcga     2100

gattctacat atggccccct tcagacacct gttggttgtg tcctaggact tgttaattcc     2160

tctttgttcg tagaggactg caagttgcct cttggtcaat ctctctgtgc tcttcctgac     2220

acacctagta ctctcacacc tcgcagtgtg cgctctgttc caggtgaaat gcgcttggca     2280

tccattgctt ttaatcatcc tattcaggtt gatcaactta atagtagtta ttttaaatta     2340

agtataccca ctaatttttc ctttggtgtg actcaggagt acattcagac aaccattcag     2400

aaagttactg ttgattgtaa acagtacgtt tgcaatggtt tccagaagtg tgagcaatta     2460

ctgcgcgagt atggccagtt ttgttccaaa ataaaccagg ctctccatgg tgccaattta     2520

cgccaggatg attctgtacg taatttgttt gcgagcgtga aaagctctca atcatctcct     2580

atcataccag gttttggagg tgactttaat ttgacacttc tagaacctgt ttctatatct     2640

actggcagtc gtagtgcacg tagtgctatt gaggatttgc tatttgacaa agtcactata     2700

gctgatcctg gttatatgca aggttacgat gattgcatgc agcaaggtcc agcatcagct     2760

cgtgatctta tttgtgctca atatgtggct ggttacaaag tattacctcc tcttatggat     2820

gttaatatgg aagccgcgta tacttcatct ttgcttggca gcatagcagg tgttggctgg     2880

actgctggct tatcctcctt tgctgctatt ccatttgcac agagtatctt ttataggtta     2940

aacggtgttg gcattactca acaggttctt tcagagaacc aaaagcttat tgccaataag     3000

tttaatcagg ctctgggagc tatgcaaaca ggcttcacta caactaatga agcttttcag     3060

aaggttcagg atgctgtgaa caacaatgca caggctctat ccaaattagc tagcgagcta     3120

tctaatactt ttggtgctat ttccgcctct attggagaca tcatacaacg tcttgatgtt     3180

ctcgaacagg acgcccaaat agacagactt attaatggcc gtttgacaac actaaatgct     3240

tttgttgcac agcagcttgt tcgttccgaa tcagctgctc tttccgctca attggctaaa     3300

gataaagtca atgagtgtgt caaggcacaa tccaagcgtt ctggattttg cggtcaaggc     3360

acacatatag tgtcctttgt tgtaaatgcc cctaatggcc tttacttcat gcatgttggt     3420

tattacccta gcaaccacat tgaggttgtt tctgcttatg gtctttgcga tgcagctaac     3480

cctactaatt gtatagcccc tgttaatggc tactttatta aaactaataa cactaggatt     3540

gttgatgagt ggtcatatac tggctcgtcc ttctatgcac ctgagcccat tacctccctt     3600

aatactaagt atgttgcacc acaggtgaca taccaaaaca tttctactaa cctccctcct     3660

cctcttctcg gcaattccac cgggattgac ttccaagatg agttggatga gtttttcaaa     3720

aatgttagca ccagtatacc taattttggt tccctaacac agattaatac tacattactc     3780

gatcttacct acgagatgtt gtctcttcaa caagttgtta aagcccttaa tgagtcttac     3840

atagacctta aagagcttgg caattatact tattacaaca aatggccgtg gtacatttgg     3900

cttggtttca ttgctgggct tgttgcctta gctctatgcg tcttcttcat actgtgctgc     3960

actggttgtg gcacaaactg tatgggaaaa cttaagtgta atcgttgttg tgatagatac     4020

gaggaatacg acctcgagcc gcataaggtt catgttcact aa                        4062


<210>  3
<211>  1353
<212>  PRT
<213>  Middle East Respiratory Syndrome Coronavirus

<400>  3

Met Ile His Ser Val Phe Leu Leu Met Phe Leu Leu Thr Pro Thr Glu 
1               5                   10                  15      


Ser Tyr Val Asp Val Gly Pro Asp Ser Val Lys Ser Ala Cys Ile Glu 
            20                  25                  30          


Val Asp Ile Gln Gln Thr Phe Phe Asp Lys Thr Trp Pro Arg Pro Ile 
        35                  40                  45              


Asp Val Ser Lys Ala Asp Gly Ile Ile Tyr Pro Gln Gly Arg Thr Tyr 
    50                  55                  60                  


Ser Asn Ile Thr Ile Thr Tyr Gln Gly Leu Phe Pro Tyr Gln Gly Asp 
65                  70                  75                  80  


His Gly Asp Met Tyr Val Tyr Ser Ala Gly His Ala Thr Gly Thr Thr 
                85                  90                  95      


Pro Gln Lys Leu Phe Val Ala Asn Tyr Ser Gln Asp Val Lys Gln Phe 
            100                 105                 110         


Ala Asn Gly Phe Val Val Arg Ile Gly Ala Ala Ala Asn Ser Thr Gly 
        115                 120                 125             


Thr Val Ile Ile Ser Pro Ser Thr Ser Ala Thr Ile Arg Lys Ile Tyr 
    130                 135                 140                 


Pro Ala Phe Met Leu Gly Ser Ser Val Gly Asn Phe Ser Asp Gly Lys 
145                 150                 155                 160 


Met Gly Arg Phe Phe Asn His Thr Leu Val Leu Leu Pro Asp Gly Cys 
                165                 170                 175     


Gly Thr Leu Leu Arg Ala Phe Tyr Cys Ile Leu Glu Pro Arg Ser Gly 
            180                 185                 190         


Asn His Cys Pro Ala Gly Asn Ser Tyr Thr Ser Phe Ala Thr Tyr His 
        195                 200                 205             


Thr Pro Ala Thr Asp Cys Ser Asp Gly Asn Tyr Asn Arg Asn Ala Ser 
    210                 215                 220                 


Leu Asn Ser Phe Lys Glu Tyr Phe Asn Leu Arg Asn Cys Thr Phe Met 
225                 230                 235                 240 


Tyr Thr Tyr Asn Ile Thr Glu Asp Glu Ile Leu Glu Trp Phe Gly Ile 
                245                 250                 255     


Thr Gln Thr Ala Gln Gly Val His Leu Phe Ser Ser Arg Tyr Val Asp 
            260                 265                 270         


Leu Tyr Gly Gly Asn Met Phe Gln Phe Ala Thr Leu Pro Val Tyr Asp 
        275                 280                 285             


Thr Ile Lys Tyr Tyr Ser Ile Ile Pro His Ser Ile Arg Ser Ile Gln 
    290                 295                 300                 


Ser Asp Arg Lys Ala Trp Ala Ala Phe Tyr Val Tyr Lys Leu Gln Pro 
305                 310                 315                 320 


Leu Thr Phe Leu Leu Asp Phe Ser Val Asp Gly Tyr Ile Arg Arg Ala 
                325                 330                 335     


Ile Asp Cys Gly Phe Asn Asp Leu Ser Gln Leu His Cys Ser Tyr Glu 
            340                 345                 350         


Ser Phe Asp Val Glu Ser Gly Val Tyr Ser Val Ser Ser Phe Glu Ala 
        355                 360                 365             


Lys Pro Ser Gly Ser Val Val Glu Gln Ala Glu Gly Val Glu Cys Asp 
    370                 375                 380                 


Phe Ser Pro Leu Leu Ser Gly Thr Pro Pro Gln Val Tyr Asn Phe Lys 
385                 390                 395                 400 


Arg Leu Val Phe Thr Asn Cys Asn Tyr Asn Leu Thr Lys Leu Leu Ser 
                405                 410                 415     


Leu Phe Ser Val Asn Asp Phe Thr Cys Ser Gln Ile Ser Pro Ala Ala 
            420                 425                 430         


Ile Ala Ser Asn Cys Tyr Ser Ser Leu Ile Leu Asp Tyr Phe Ser Tyr 
        435                 440                 445             


Pro Leu Ser Met Lys Ser Asp Leu Gly Val Ser Ser Ala Gly Pro Ile 
    450                 455                 460                 


Ser Gln Phe Asn Tyr Lys Gln Ser Phe Ser Asn Pro Thr Cys Leu Ile 
465                 470                 475                 480 


Leu Ala Thr Val Pro His Asn Leu Thr Thr Ile Thr Lys Pro Leu Lys 
                485                 490                 495     


Tyr Ser Tyr Ile Asn Lys Cys Ser Arg Leu Leu Ser Asp Asp Arg Thr 
            500                 505                 510         


Glu Val Pro Gln Leu Val Asn Ala Asn Gln Tyr Ser Pro Cys Val Ser 
        515                 520                 525             


Ile Val Pro Ser Thr Val Trp Glu Asp Gly Asp Tyr Tyr Arg Lys Gln 
    530                 535                 540                 


Leu Ser Pro Leu Glu Gly Gly Gly Trp Leu Val Ala Ser Gly Ser Thr 
545                 550                 555                 560 


Val Ala Met Thr Glu Gln Leu Gln Met Gly Phe Gly Ile Thr Val Gln 
                565                 570                 575     


Tyr Gly Thr Asp Thr Asn Ser Val Cys Pro Lys Leu Glu Phe Ala Asn 
            580                 585                 590         


Asp Thr Lys Ile Ala Ser Gln Leu Gly Asn Cys Val Glu Tyr Ser Leu 
        595                 600                 605             


Tyr Gly Val Ser Gly Arg Gly Val Phe Gln Asn Cys Thr Ala Val Gly 
    610                 615                 620                 


Val Arg Gln Gln Arg Phe Val Tyr Asp Ala Tyr Gln Asn Leu Val Gly 
625                 630                 635                 640 


Tyr Tyr Ser Asp Asp Gly Asn Tyr Tyr Cys Leu Arg Ala Cys Val Ser 
                645                 650                 655     


Val Pro Val Ser Val Ile Tyr Asp Lys Glu Thr Lys Thr His Ala Thr 
            660                 665                 670         


Leu Phe Gly Ser Val Ala Cys Glu His Ile Ser Ser Thr Met Ser Gln 
        675                 680                 685             


Tyr Ser Arg Ser Thr Arg Ser Met Leu Lys Arg Arg Asp Ser Thr Tyr 
    690                 695                 700                 


Gly Pro Leu Gln Thr Pro Val Gly Cys Val Leu Gly Leu Val Asn Ser 
705                 710                 715                 720 


Ser Leu Phe Val Glu Asp Cys Lys Leu Pro Leu Gly Gln Ser Leu Cys 
                725                 730                 735     


Ala Leu Pro Asp Thr Pro Ser Thr Leu Thr Pro Arg Ser Val Arg Ser 
            740                 745                 750         


Val Pro Gly Glu Met Arg Leu Ala Ser Ile Ala Phe Asn His Pro Ile 
        755                 760                 765             


Gln Val Asp Gln Phe Asn Ser Ser Tyr Phe Lys Leu Ser Ile Pro Thr 
    770                 775                 780                 


Asn Phe Ser Phe Gly Val Thr Gln Glu Tyr Ile Gln Thr Thr Ile Gln 
785                 790                 795                 800 


Lys Val Thr Val Asp Cys Lys Gln Tyr Ile Cys Asn Gly Phe Gln Lys 
                805                 810                 815     


Cys Glu Gln Leu Leu Arg Glu Tyr Gly Gln Phe Cys Ser Lys Ile Asn 
            820                 825                 830         


Gln Ala Leu His Gly Ala Asn Leu Arg Gln Asp Asp Ser Val Arg Asn 
        835                 840                 845             


Leu Phe Ala Ser Val Lys Ser Ser Gln Ser Ser Pro Ile Ile Pro Gly 
    850                 855                 860                 


Phe Gly Gly Asp Phe Asn Leu Thr Leu Leu Glu Pro Val Ser Ile Ser 
865                 870                 875                 880 


Thr Gly Ser Arg Ser Ala Arg Ser Ala Ile Glu Asp Leu Leu Phe Asp 
                885                 890                 895     


Lys Val Thr Ile Ala Asp Pro Gly Tyr Met Gln Gly Tyr Asp Asp Cys 
            900                 905                 910         


Met Gln Gln Gly Pro Ala Ser Ala Arg Asp Leu Ile Cys Ala Gln Tyr 
        915                 920                 925             


Val Ala Gly Tyr Lys Val Leu Pro Pro Leu Met Asp Val Asn Met Glu 
    930                 935                 940                 


Ala Ala Tyr Thr Ser Ser Leu Leu Gly Ser Ile Ala Gly Val Gly Trp 
945                 950                 955                 960 


Thr Ala Gly Leu Ser Ser Phe Ala Ala Ile Pro Phe Ala Gln Ser Ile 
                965                 970                 975     


Phe Tyr Arg Leu Asn Gly Val Gly Ile Thr Gln Gln Val Leu Ser Glu 
            980                 985                 990         


Asn Gln Lys Leu Ile Ala Asn Lys  Phe Asn Gln Ala Leu  Gly Ala Met 
        995                 1000                 1005             


Gln Thr  Gly Phe Thr Thr Thr  Asn Glu Ala Phe Arg  Lys Val Gln 
    1010                 1015                 1020             


Asp Ala  Val Asn Asn Asn Ala  Gln Ala Leu Ser Lys  Leu Ala Ser 
    1025                 1030                 1035             


Glu Leu  Ser Asn Thr Phe Gly  Ala Ile Ser Ala Ser  Ile Gly Asp 
    1040                 1045                 1050             


Ile Ile  Gln Arg Leu Asp Val  Leu Glu Gln Asp Ala  Gln Ile Asp 
    1055                 1060                 1065             


Arg Leu  Ile Asn Gly Arg Leu  Thr Thr Leu Asn Ala  Phe Val Ala 
    1070                 1075                 1080             


Gln Gln  Leu Val Arg Ser Glu  Ser Ala Ala Leu Ser  Ala Gln Leu 
    1085                 1090                 1095             


Ala Lys  Asp Lys Val Asn Glu  Cys Val Lys Ala Gln  Ser Lys Arg 
    1100                 1105                 1110             


Ser Gly  Phe Cys Gly Gln Gly  Thr His Ile Val Ser  Phe Val Val 
    1115                 1120                 1125             


Asn Ala  Pro Asn Gly Leu Tyr  Phe Met His Val Gly  Tyr Tyr Pro 
    1130                 1135                 1140             


Ser Asn  His Ile Glu Val Val  Ser Ala Tyr Gly Leu  Cys Asp Ala 
    1145                 1150                 1155             


Ala Asn  Pro Thr Asn Cys Ile  Ala Pro Val Asn Gly  Tyr Phe Ile 
    1160                 1165                 1170             


Lys Thr  Asn Asn Thr Arg Ile  Val Asp Glu Trp Ser  Tyr Thr Gly 
    1175                 1180                 1185             


Ser Ser  Phe Tyr Ser Pro Glu  Pro Ile Thr Ser Leu  Asn Thr Lys 
    1190                 1195                 1200             


Tyr Val  Ala Pro Gln Val Thr  Tyr Gln Asn Ile Ser  Thr Asn Leu 
    1205                 1210                 1215             


Pro Pro  Pro Leu Leu Gly Asn  Ser Thr Gly Ile Asp  Phe Gln Asp 
    1220                 1225                 1230             


Glu Leu  Asp Glu Phe Phe Lys  Asn Val Ser Thr Ser  Ile Pro Asn 
    1235                 1240                 1245             


Phe Gly  Ser Leu Thr Gln Ile  Asn Thr Thr Leu Leu  Asp Leu Thr 
    1250                 1255                 1260             


Tyr Glu  Met Leu Ser Leu Gln  Gln Val Val Lys Ala  Leu Asn Glu 
    1265                 1270                 1275             


Ser Tyr  Ile Asp Leu Lys Glu  Leu Gly Asn Tyr Thr  Tyr Tyr Asn 
    1280                 1285                 1290             


Lys Trp  Pro Trp Tyr Ile Trp  Leu Gly Phe Ile Ala  Gly Leu Val 
    1295                 1300                 1305             


Ala Leu  Ala Leu Cys Val Phe  Phe Ile Leu Cys Cys  Thr Gly Cys 
    1310                 1315                 1320             


Gly Thr  Asn Cys Met Gly Lys  Leu Lys Cys Asn Arg  Cys Cys Asp 
    1325                 1330                 1335             


Arg Tyr  Glu Glu Tyr Asp Leu  Glu Pro His Lys Val  His Val His 
    1340                 1345                 1350             


<210>  4
<211>  1353
<212>  PRT
<213>  Middle East Respiratory Syndrome Coronavirus

<400>  4

Met Ile His Ser Val Phe Leu Leu Met Phe Leu Leu Thr Pro Thr Glu 
1               5                   10                  15      


Ser Tyr Val Asp Val Gly Pro Asp Ser Val Lys Ser Ala Cys Ile Glu 
            20                  25                  30          


Val Asp Ile Gln Gln Thr Phe Phe Asp Lys Thr Trp Pro Arg Pro Ile 
        35                  40                  45              


Asp Val Ser Lys Ala Asp Gly Ile Ile Tyr Pro Gln Gly Arg Thr Tyr 
    50                  55                  60                  


Ser Asn Ile Thr Ile Thr Tyr Gln Gly Leu Phe Pro Tyr Gln Gly Asp 
65                  70                  75                  80  


His Gly Asp Met Tyr Val Tyr Ser Ala Gly His Ala Thr Gly Thr Thr 
                85                  90                  95      


Pro Gln Lys Leu Phe Val Ala Asn Tyr Ser Gln Asp Val Lys Gln Phe 
            100                 105                 110         


Ala Asn Gly Phe Val Val Arg Ile Gly Ala Ala Ala Asn Ser Thr Gly 
        115                 120                 125             


Thr Val Ile Ile Ser Pro Ser Thr Ser Ala Thr Ile Arg Lys Ile Tyr 
    130                 135                 140                 


Pro Ala Phe Met Leu Gly Ser Ser Val Gly Asn Phe Ser Asp Gly Lys 
145                 150                 155                 160 


Met Gly Arg Phe Phe Asn His Thr Leu Val Leu Leu Pro Asp Gly Cys 
                165                 170                 175     


Gly Thr Leu Leu Arg Ala Phe Tyr Cys Ile Leu Glu Pro Arg Ser Gly 
            180                 185                 190         


Asn His Cys Pro Ala Gly Asn Ser Tyr Thr Ser Phe Ala Thr Tyr His 
        195                 200                 205             


Thr Pro Ala Thr Asp Cys Ser Asp Gly Asn Tyr Asn Arg Asn Ala Ser 
    210                 215                 220                 


Leu Asn Ser Phe Lys Glu Tyr Phe Asn Leu Arg Asn Cys Thr Phe Met 
225                 230                 235                 240 


Tyr Thr Tyr Asn Ile Thr Glu Asp Glu Ile Leu Glu Trp Phe Gly Ile 
                245                 250                 255     


Thr Gln Thr Ala Gln Gly Val His Leu Phe Ser Ser Arg Tyr Val Asp 
            260                 265                 270         


Leu Tyr Gly Gly Asn Met Phe Gln Phe Ala Thr Leu Pro Val Tyr Asp 
        275                 280                 285             


Thr Ile Lys Tyr Tyr Ser Ile Ile Pro His Ser Ile Arg Ser Ile Gln 
    290                 295                 300                 


Ser Asp Arg Lys Ala Trp Ala Ala Phe Tyr Val Tyr Lys Leu Gln Pro 
305                 310                 315                 320 


Leu Thr Phe Leu Leu Asp Phe Ser Val Asp Gly Tyr Ile Arg Arg Ala 
                325                 330                 335     


Ile Asp Cys Gly Phe Asn Asp Leu Ser Gln Leu His Cys Ser Tyr Glu 
            340                 345                 350         


Ser Phe Asp Val Glu Ser Gly Val Tyr Ser Val Ser Ser Phe Glu Ala 
        355                 360                 365             


Lys Pro Ser Gly Ser Val Val Glu Gln Ala Glu Gly Val Glu Cys Asp 
    370                 375                 380                 


Phe Ser Pro Leu Leu Ser Gly Thr Pro Pro Gln Val Tyr Asn Phe Lys 
385                 390                 395                 400 


Arg Leu Val Phe Thr Asn Cys Asn Tyr Asn Leu Thr Lys Leu Leu Ser 
                405                 410                 415     


Leu Phe Ser Val Asn Asp Phe Thr Cys Ser Gln Ile Ser Pro Ala Ala 
            420                 425                 430         


Ile Ala Ser Asn Cys Tyr Ser Ser Leu Ile Leu Asp Tyr Phe Ser Tyr 
        435                 440                 445             


Pro Leu Ser Met Lys Ser Asp Leu Gly Val Ser Ser Ala Gly Pro Ile 
    450                 455                 460                 


Ser Gln Phe Asn Tyr Lys Gln Ser Phe Ser Asn Pro Thr Cys Leu Ile 
465                 470                 475                 480 


Leu Ala Thr Val Pro His Asn Leu Thr Thr Ile Thr Lys Pro Leu Lys 
                485                 490                 495     


Tyr Ser Tyr Ile Asn Lys Cys Ser Arg Leu Leu Ser Asp Asp Arg Thr 
            500                 505                 510         


Glu Val Pro Gln Leu Val Asn Ala Asn Gln Tyr Ser Pro Cys Val Ser 
        515                 520                 525             


Ile Val Pro Ser Thr Val Trp Glu Asp Gly Asp Tyr Tyr Arg Lys Gln 
    530                 535                 540                 


Leu Ser Pro Leu Glu Gly Gly Gly Trp Leu Val Ala Ser Gly Ser Thr 
545                 550                 555                 560 


Val Ala Met Thr Glu Gln Leu Gln Met Gly Phe Gly Ile Thr Val Gln 
                565                 570                 575     


Tyr Gly Thr Asp Thr Asn Ser Val Cys Pro Lys Leu Glu Phe Ala Asn 
            580                 585                 590         


Asp Thr Lys Ile Ala Ser Gln Leu Gly Asn Cys Val Glu Tyr Ser Leu 
        595                 600                 605             


Tyr Gly Val Ser Gly Arg Gly Val Phe Gln Asn Cys Thr Ala Val Gly 
    610                 615                 620                 


Val Arg Gln Gln Arg Phe Val Tyr Asp Ala Tyr Gln Asn Leu Val Gly 
625                 630                 635                 640 


Tyr Tyr Ser Asp Asp Gly Asn Tyr Tyr Cys Leu Arg Ala Cys Val Ser 
                645                 650                 655     


Val Pro Val Ser Val Ile Tyr Asp Lys Glu Thr Lys Thr His Ala Thr 
            660                 665                 670         


Leu Phe Gly Ser Val Ala Cys Glu His Ile Ser Ser Thr Met Ser Gln 
        675                 680                 685             


Tyr Ser Arg Ser Thr Arg Ser Met Leu Lys Arg Arg Asp Ser Thr Tyr 
    690                 695                 700                 


Gly Pro Leu Gln Thr Pro Val Gly Cys Val Leu Gly Leu Val Asn Ser 
705                 710                 715                 720 


Ser Leu Phe Val Glu Asp Cys Lys Leu Pro Leu Gly Gln Ser Leu Cys 
                725                 730                 735     


Ala Leu Pro Asp Thr Pro Ser Thr Leu Thr Pro Arg Ser Val Arg Ser 
            740                 745                 750         


Val Pro Gly Glu Met Arg Leu Ala Ser Ile Ala Phe Asn His Pro Ile 
        755                 760                 765             


Gln Val Asp Gln Phe Asn Ser Ser Tyr Phe Lys Leu Ser Ile Pro Thr 
    770                 775                 780                 


Asn Phe Ser Phe Gly Val Thr Gln Glu Tyr Ile Gln Thr Thr Ile Gln 
785                 790                 795                 800 


Lys Val Thr Val Asp Cys Lys Gln Tyr Ile Cys Asn Gly Phe Gln Lys 
                805                 810                 815     


Cys Glu Gln Leu Leu Arg Glu Tyr Gly Gln Phe Cys Ser Lys Ile Asn 
            820                 825                 830         


Gln Ala Leu His Gly Ala Asn Leu Arg Gln Asp Asp Ser Val Arg Asn 
        835                 840                 845             


Leu Phe Ala Ser Val Lys Ser Ser Gln Ser Ser Pro Ile Ile Pro Gly 
    850                 855                 860                 


Phe Gly Gly Asp Phe Asn Leu Thr Leu Leu Glu Pro Val Ser Ile Ser 
865                 870                 875                 880 


Thr Gly Ser Arg Ser Ala Arg Ser Ala Ile Glu Asp Leu Leu Phe Asp 
                885                 890                 895     


Lys Val Thr Ile Ala Asp Pro Gly Tyr Met Gln Gly Tyr Asp Asp Cys 
            900                 905                 910         


Met Gln Gln Gly Pro Ala Ser Ala Arg Asp Leu Ile Cys Ala Gln Tyr 
        915                 920                 925             


Val Ala Gly Tyr Lys Val Leu Pro Pro Leu Met Asp Val Asn Met Glu 
    930                 935                 940                 


Ala Ala Tyr Thr Ser Ser Leu Leu Gly Ser Ile Ala Gly Val Gly Trp 
945                 950                 955                 960 


Thr Ala Gly Leu Ser Ser Phe Ala Ala Ile Pro Phe Ala Gln Ser Ile 
                965                 970                 975     


Phe Tyr Arg Leu Asn Gly Val Gly Ile Thr Gln Gln Val Leu Ser Glu 
            980                 985                 990         


Asn Gln Lys Leu Ile Ala Asn Lys  Phe Asn Gln Ala Leu  Gly Ala Met 
        995                 1000                 1005             


Gln Thr  Gly Phe Thr Thr Thr  Asn Glu Ala Phe Arg  Lys Val Gln 
    1010                 1015                 1020             


Asp Ala  Val Asn Asn Asn Ala  Gln Ala Leu Ser Lys  Leu Ala Ser 
    1025                 1030                 1035             


Glu Leu  Ser Asn Thr Phe Gly  Ala Ile Ser Ala Ser  Ile Gly Asp 
    1040                 1045                 1050             


Ile Ile  Gln Arg Leu Asp Val  Leu Glu Gln Asp Ala  Gln Ile Asp 
    1055                 1060                 1065             


Arg Leu  Ile Asn Gly Arg Leu  Thr Thr Leu Asn Ala  Phe Val Ala 
    1070                 1075                 1080             


Gln Gln  Leu Val Arg Ser Glu  Ser Ala Ala Leu Ser  Ala Gln Leu 
    1085                 1090                 1095             


Ala Lys  Asp Lys Val Asn Glu  Cys Val Lys Ala Gln  Ser Lys Arg 
    1100                 1105                 1110             


Ser Gly  Phe Cys Gly Gln Gly  Thr His Ile Val Ser  Phe Val Val 
    1115                 1120                 1125             


Asn Ala  Pro Asn Gly Leu Tyr  Phe Met His Val Gly  Tyr Tyr Pro 
    1130                 1135                 1140             


Ser Asn  His Ile Glu Val Val  Ser Ala Tyr Gly Leu  Cys Asp Ala 
    1145                 1150                 1155             


Ala Asn  Pro Thr Asn Cys Ile  Ala Pro Val Asn Gly  Tyr Phe Ile 
    1160                 1165                 1170             


Lys Thr  Asn Asn Thr Arg Ile  Val Asp Glu Trp Ser  Tyr Thr Gly 
    1175                 1180                 1185             


Ser Ser  Phe Tyr Ser Pro Glu  Pro Ile Thr Ser Leu  Asn Thr Lys 
    1190                 1195                 1200             


Tyr Val  Ala Pro Gln Val Thr  Tyr Gln Asn Ile Ser  Thr Asn Leu 
    1205                 1210                 1215             


Pro Pro  Pro Leu Leu Gly Asn  Ser Thr Gly Ile Asp  Phe Gln Asp 
    1220                 1225                 1230             


Glu Leu  Asp Glu Phe Phe Lys  Asn Val Ser Thr Ser  Ile Pro Asn 
    1235                 1240                 1245             


Phe Gly  Ser Leu Thr Gln Ile  Asn Thr Thr Leu Leu  Asp Leu Thr 
    1250                 1255                 1260             


Tyr Glu  Met Leu Ser Leu Gln  Gln Val Val Lys Ala  Leu Asn Glu 
    1265                 1270                 1275             


Ser Tyr  Ile Asp Leu Lys Glu  Leu Gly Asn Tyr Thr  Tyr Tyr Asn 
    1280                 1285                 1290             


Lys Trp  Pro Trp Tyr Ile Trp  Leu Gly Phe Ile Ala  Gly Leu Val 
    1295                 1300                 1305             


Ala Leu  Ala Leu Cys Val Phe  Phe Ile Leu Cys Cys  Thr Gly Cys 
    1310                 1315                 1320             


Gly Thr  Asn Cys Met Gly Lys  Leu Lys Cys Asn Arg  Cys Cys Asp 
    1325                 1330                 1335             


Arg Tyr  Glu Glu Tyr Asp Leu  Glu Pro His Lys Val  His Val His 
    1340                 1345                 1350             


<210>  5
<211>  1255
<212>  PRT
<213>  Severe Acute Respiratory Syndrome Coronavirus

<400>  5

Met Phe Ile Phe Leu Leu Phe Leu Thr Leu Thr Ser Gly Ser Asp Leu 
1               5                   10                  15      


Asp Arg Cys Thr Thr Phe Asp Asp Val Gln Ala Pro Asn Tyr Thr Gln 
            20                  25                  30          


His Thr Ser Ser Met Arg Gly Val Tyr Tyr Pro Asp Glu Ile Phe Arg 
        35                  40                  45              


Ser Asp Thr Leu Tyr Leu Thr Gln Asp Leu Phe Leu Pro Phe Tyr Ser 
    50                  55                  60                  


Asn Val Thr Gly Phe His Thr Ile Asn His Thr Phe Gly Asn Pro Val 
65                  70                  75                  80  


Ile Pro Phe Lys Asp Gly Ile Tyr Phe Ala Ala Thr Glu Lys Ser Asn 
                85                  90                  95      


Val Val Arg Gly Trp Val Phe Gly Ser Thr Met Asn Asn Lys Ser Gln 
            100                 105                 110         


Ser Val Ile Ile Ile Asn Asn Ser Thr Asn Val Val Ile Arg Ala Cys 
        115                 120                 125             


Asn Phe Glu Leu Cys Asp Asn Pro Phe Phe Ala Val Ser Lys Pro Met 
    130                 135                 140                 


Gly Thr Gln Thr His Thr Met Ile Phe Asp Asn Ala Phe Asn Cys Thr 
145                 150                 155                 160 


Phe Glu Tyr Ile Ser Asp Ala Phe Ser Leu Asp Val Ser Glu Lys Ser 
                165                 170                 175     


Gly Asn Phe Lys His Leu Arg Glu Phe Val Phe Lys Asn Lys Asp Gly 
            180                 185                 190         


Phe Leu Tyr Val Tyr Lys Gly Tyr Gln Pro Ile Asp Val Val Arg Asp 
        195                 200                 205             


Leu Pro Ser Gly Phe Asn Thr Leu Lys Pro Ile Phe Lys Leu Pro Leu 
    210                 215                 220                 


Gly Ile Asn Ile Thr Asn Phe Arg Ala Ile Leu Thr Ala Phe Ser Pro 
225                 230                 235                 240 


Ala Gln Asp Ile Trp Gly Thr Ser Ala Ala Ala Tyr Phe Val Gly Tyr 
                245                 250                 255     


Leu Lys Pro Thr Thr Phe Met Leu Lys Tyr Asp Glu Asn Gly Thr Ile 
            260                 265                 270         


Thr Asp Ala Val Asp Cys Ser Gln Asn Pro Leu Ala Glu Leu Lys Cys 
        275                 280                 285             


Ser Val Lys Ser Phe Glu Ile Asp Lys Gly Ile Tyr Gln Thr Ser Asn 
    290                 295                 300                 


Phe Arg Val Val Pro Ser Gly Asp Val Val Arg Phe Pro Asn Ile Thr 
305                 310                 315                 320 


Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Lys Phe Pro Ser 
                325                 330                 335     


Val Tyr Ala Trp Glu Arg Lys Lys Ile Ser Asn Cys Val Ala Asp Tyr 
            340                 345                 350         


Ser Val Leu Tyr Asn Ser Thr Phe Phe Ser Thr Phe Lys Cys Tyr Gly 
        355                 360                 365             


Val Ser Ala Thr Lys Leu Asn Asp Leu Cys Phe Ser Asn Val Tyr Ala 
    370                 375                 380                 


Asp Ser Phe Val Val Lys Gly Asp Asp Val Arg Gln Ile Ala Pro Gly 
385                 390                 395                 400 


Gln Thr Gly Val Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe 
                405                 410                 415     


Met Gly Cys Val Leu Ala Trp Asn Thr Arg Asn Ile Asp Ala Thr Ser 
            420                 425                 430         


Thr Gly Asn Tyr Asn Tyr Lys Tyr Arg Tyr Leu Arg His Gly Lys Leu 
        435                 440                 445             


Arg Pro Phe Glu Arg Asp Ile Ser Asn Val Pro Phe Ser Pro Asp Gly 
    450                 455                 460                 


Lys Pro Cys Thr Pro Pro Ala Leu Asn Cys Tyr Trp Pro Leu Asn Asp 
465                 470                 475                 480 


Tyr Gly Phe Tyr Thr Thr Thr Gly Ile Gly Tyr Gln Pro Tyr Arg Val 
                485                 490                 495     


Val Val Leu Ser Phe Glu Leu Leu Asn Ala Pro Ala Thr Val Cys Gly 
            500                 505                 510         


Pro Lys Leu Ser Thr Asp Leu Ile Lys Asn Gln Cys Val Asn Phe Asn 
        515                 520                 525             


Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Pro Ser Ser Lys Arg 
    530                 535                 540                 


Phe Gln Pro Phe Gln Gln Phe Gly Arg Asp Val Ser Asp Phe Thr Asp 
545                 550                 555                 560 


Ser Val Arg Asp Pro Lys Thr Ser Glu Ile Leu Asp Ile Ser Pro Cys 
                565                 570                 575     


Ala Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Ala Ser Ser 
            580                 585                 590         


Glu Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Asn Val Ser Ala 
        595                 600                 605             


Ala Ile His Ala Asp Gln Leu Thr Pro Ala Trp Arg Ile Tyr Ser Thr 
    610                 615                 620                 


Gly Asn Asn Val Phe Gln Thr Gln Ala Gly Cys Leu Ile Gly Ala Glu 
625                 630                 635                 640 


His Val Asp Thr Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile 
                645                 650                 655     


Cys Ala Ser Tyr His Thr Val Ser Leu Leu Arg Ser Thr Ser Gln Lys 
            660                 665                 670         


Ser Ile Val Ala Tyr Thr Met Ser Leu Gly Ala Asp Ser Ser Ile Ala 
        675                 680                 685             


Tyr Ser Asn Asn Thr Ile Ala Ile Pro Thr Asn Phe Ser Ile Ser Ile 
    690                 695                 700                 


Thr Thr Glu Val Met Pro Val Ser Met Ala Lys Thr Ser Val Asp Cys 
705                 710                 715                 720 


Asn Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ala Asn Leu Leu Leu 
                725                 730                 735     


Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Ser Gly Ile 
            740                 745                 750         


Ala Ala Glu Gln Asp Arg Asn Thr Arg Glu Val Phe Ala Gln Val Lys 
        755                 760                 765             


Gln Met Tyr Lys Thr Pro Thr Leu Lys Tyr Phe Gly Gly Phe Asn Phe 
    770                 775                 780                 


Ser Gln Ile Leu Pro Asp Pro Leu Lys Pro Thr Lys Arg Ser Phe Ile 
785                 790                 795                 800 


Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly Phe Met 
                805                 810                 815     


Lys Gln Tyr Gly Glu Cys Leu Gly Asp Ile Asn Ala Arg Asp Leu Ile 
            820                 825                 830         


Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu Leu Thr 
        835                 840                 845             


Asp Asp Met Ile Ala Ala Tyr Thr Ala Ala Leu Val Ser Gly Thr Ala 
    850                 855                 860                 


Thr Ala Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile Pro Phe 
865                 870                 875                 880 


Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln Asn 
                885                 890                 895     


Val Leu Tyr Glu Asn Gln Lys Gln Ile Ala Asn Gln Phe Asn Lys Ala 
            900                 905                 910         


Ile Ser Gln Ile Gln Glu Ser Leu Thr Thr Thr Ser Thr Ala Leu Gly 
        915                 920                 925             


Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn Thr Leu 
    930                 935                 940                 


Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val Leu Asn 
945                 950                 955                 960 


Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln Ile Asp 
                965                 970                 975     


Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln Thr Tyr Val Thr Gln 
            980                 985                 990         


Gln Leu Ile Arg Ala Ala Glu Ile  Arg Ala Ser Ala Asn  Leu Ala Ala 
        995                 1000                 1005             


Thr Lys  Met Ser Glu Cys Val  Leu Gly Gln Ser Lys  Arg Val Asp 
    1010                 1015                 1020             


Phe Cys  Gly Lys Gly Tyr His  Leu Met Ser Phe Pro  Gln Ala Ala 
    1025                 1030                 1035             


Pro His  Gly Val Val Phe Leu  His Val Thr Tyr Val  Pro Ser Gln 
    1040                 1045                 1050             


Glu Arg  Asn Phe Thr Thr Ala  Pro Ala Ile Cys His  Glu Gly Lys 
    1055                 1060                 1065             


Ala Tyr  Phe Pro Arg Glu Gly  Val Phe Val Phe Asn  Gly Thr Ser 
    1070                 1075                 1080             


Trp Phe  Ile Thr Gln Arg Asn  Phe Phe Ser Pro Gln  Ile Ile Thr 
    1085                 1090                 1095             


Thr Asp  Asn Thr Phe Val Ser  Gly Asn Cys Asp Val  Val Ile Gly 
    1100                 1105                 1110             


Ile Ile  Asn Asn Thr Val Tyr  Asp Pro Leu Gln Pro  Glu Leu Asp 
    1115                 1120                 1125             


Ser Phe  Lys Gly Glu Leu Asp  Lys Tyr Phe Lys Asn  His Thr Ser 
    1130                 1135                 1140             


Pro Asp  Val Asp Leu Gly Asp  Ile Ser Gly Ile Asn  Ala Ser Val 
    1145                 1150                 1155             


Val Asn  Ile Gln Lys Glu Ile  Asp Arg Leu Asn Glu  Val Ala Lys 
    1160                 1165                 1170             


Asn Leu  Asn Glu Ser Leu Ile  Asp Leu Gln Glu Leu  Gly Lys Tyr 
    1175                 1180                 1185             


Glu Gln  Tyr Ile Lys Trp Pro  Trp Tyr Val Trp Leu  Gly Phe Ile 
    1190                 1195                 1200             


Ala Gly  Leu Ile Ala Ile Val  Met Val Thr Ile Leu  Leu Cys Cys 
    1205                 1210                 1215             


Met Thr  Ser Cys Cys Ser Cys  Leu Lys Gly Ala Cys  Ser Cys Gly 
    1220                 1225                 1230             


Ser Cys  Cys Lys Phe Asp Glu  Asp Asp Ser Glu Pro  Val Leu Lys 
    1235                 1240                 1245             


Gly Val  Lys Leu His Tyr Thr  
    1250                 1255 


<210>  6
<211>  1255
<212>  PRT
<213>  Severe Acute Respiratory Syndrome Coronavirus

<400>  6

Met Phe Ile Phe Leu Leu Phe Leu Thr Leu Thr Ser Gly Ser Asp Leu 
1               5                   10                  15      


Asp Arg Cys Thr Thr Phe Asp Asp Val Gln Ala Pro Asn Tyr Thr Gln 
            20                  25                  30          


His Thr Ser Ser Met Arg Gly Val Tyr Tyr Pro Asp Glu Ile Phe Arg 
        35                  40                  45              


Ser Asp Thr Leu Tyr Leu Thr Gln Asp Leu Phe Leu Pro Phe Tyr Ser 
    50                  55                  60                  


Asn Val Thr Gly Phe His Thr Ile Asn His Thr Phe Gly Asn Pro Val 
65                  70                  75                  80  


Ile Pro Phe Lys Asp Gly Ile Tyr Phe Ala Ala Thr Glu Lys Ser Asn 
                85                  90                  95      


Val Val Arg Gly Trp Val Phe Gly Ser Thr Met Asn Asn Lys Ser Gln 
            100                 105                 110         


Ser Val Ile Ile Ile Asn Asn Ser Thr Asn Val Val Ile Arg Ala Cys 
        115                 120                 125             


Asn Phe Glu Leu Cys Asp Asn Pro Phe Phe Ala Val Ser Lys Pro Met 
    130                 135                 140                 


Gly Thr Gln Thr His Thr Met Ile Phe Asp Asn Ala Phe Asn Cys Thr 
145                 150                 155                 160 


Phe Glu Tyr Ile Ser Asp Ala Phe Ser Leu Asp Val Ser Glu Lys Ser 
                165                 170                 175     


Gly Asn Phe Lys His Leu Arg Glu Phe Val Phe Lys Asn Lys Asp Gly 
            180                 185                 190         


Phe Leu Tyr Val Tyr Lys Gly Tyr Gln Pro Ile Asp Val Val Arg Asp 
        195                 200                 205             


Leu Pro Ser Gly Phe Asn Thr Leu Lys Pro Ile Phe Lys Leu Pro Leu 
    210                 215                 220                 


Gly Ile Asn Ile Thr Asn Phe Arg Ala Ile Leu Thr Ala Phe Ser Pro 
225                 230                 235                 240 


Ala Gln Asp Ile Trp Gly Thr Ser Ala Ala Ala Tyr Phe Val Gly Tyr 
                245                 250                 255     


Leu Lys Pro Thr Thr Phe Met Leu Lys Tyr Asp Glu Asn Gly Thr Ile 
            260                 265                 270         


Thr Asp Ala Val Asp Cys Ser Gln Asn Pro Leu Ala Glu Leu Lys Cys 
        275                 280                 285             


Ser Val Lys Ser Phe Glu Ile Asp Lys Gly Ile Tyr Gln Thr Ser Asn 
    290                 295                 300                 


Phe Arg Val Val Pro Ser Gly Asp Val Val Arg Phe Pro Asn Ile Thr 
305                 310                 315                 320 


Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Lys Phe Pro Ser 
                325                 330                 335     


Val Tyr Ala Trp Glu Arg Lys Lys Ile Ser Asn Cys Val Ala Asp Tyr 
            340                 345                 350         


Ser Val Leu Tyr Asn Ser Thr Phe Phe Ser Thr Phe Lys Cys Tyr Gly 
        355                 360                 365             


Val Ser Ala Thr Lys Leu Asn Asp Leu Cys Phe Ser Asn Val Tyr Ala 
    370                 375                 380                 


Asp Ser Phe Val Val Lys Gly Asp Asp Val Arg Gln Ile Ala Pro Gly 
385                 390                 395                 400 


Gln Thr Gly Val Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe 
                405                 410                 415     


Met Gly Cys Val Leu Ala Trp Asn Thr Arg Asn Ile Asp Ala Thr Ser 
            420                 425                 430         


Thr Gly Asn Tyr Asn Tyr Lys Tyr Arg Tyr Leu Arg His Gly Lys Leu 
        435                 440                 445             


Arg Pro Phe Glu Arg Asp Ile Ser Asn Val Pro Phe Ser Pro Asp Gly 
    450                 455                 460                 


Lys Pro Cys Thr Pro Pro Ala Leu Asn Cys Tyr Trp Pro Leu Asn Asp 
465                 470                 475                 480 


Tyr Gly Phe Tyr Thr Thr Thr Gly Ile Gly Tyr Gln Pro Tyr Arg Val 
                485                 490                 495     


Val Val Leu Ser Phe Glu Leu Leu Asn Ala Pro Ala Thr Val Cys Gly 
            500                 505                 510         


Pro Lys Leu Ser Thr Asp Leu Ile Lys Asn Gln Cys Val Asn Phe Asn 
        515                 520                 525             


Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Pro Ser Ser Lys Arg 
    530                 535                 540                 


Phe Gln Pro Phe Gln Gln Phe Gly Arg Asp Val Ser Asp Phe Thr Asp 
545                 550                 555                 560 


Ser Val Arg Asp Pro Lys Thr Ser Glu Ile Leu Asp Ile Ser Pro Cys 
                565                 570                 575     


Ala Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Ala Ser Ser 
            580                 585                 590         


Glu Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Asn Val Ser Ala 
        595                 600                 605             


Ala Ile His Ala Asp Gln Leu Thr Pro Ala Trp Arg Ile Tyr Ser Thr 
    610                 615                 620                 


Gly Asn Asn Val Phe Gln Thr Gln Ala Gly Cys Leu Ile Gly Ala Glu 
625                 630                 635                 640 


His Val Asp Thr Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile 
                645                 650                 655     


Cys Ala Ser Tyr His Thr Val Ser Leu Leu Arg Ser Thr Ser Gln Lys 
            660                 665                 670         


Ser Ile Val Ala Tyr Thr Met Ser Leu Gly Ala Asp Ser Ser Ile Ala 
        675                 680                 685             


Tyr Ser Asn Asn Thr Ile Ala Ile Pro Thr Asn Phe Ser Ile Ser Ile 
    690                 695                 700                 


Thr Thr Glu Val Met Pro Val Ser Met Ala Lys Thr Ser Val Asp Cys 
705                 710                 715                 720 


Asn Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ala Asn Leu Leu Leu 
                725                 730                 735     


Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Ser Gly Ile 
            740                 745                 750         


Ala Ala Glu Gln Asp Arg Asn Thr Arg Glu Val Phe Ala Gln Val Lys 
        755                 760                 765             


Gln Met Tyr Lys Thr Pro Thr Leu Lys Tyr Phe Gly Gly Phe Asn Phe 
    770                 775                 780                 


Ser Gln Ile Leu Pro Asp Pro Leu Lys Pro Thr Lys Arg Ser Phe Ile 
785                 790                 795                 800 


Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly Phe Met 
                805                 810                 815     


Lys Gln Tyr Gly Glu Cys Leu Gly Asp Ile Asn Ala Arg Asp Leu Ile 
            820                 825                 830         


Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu Leu Thr 
        835                 840                 845             


Asp Asp Met Ile Ala Ala Tyr Thr Ala Ala Leu Val Ser Gly Thr Ala 
    850                 855                 860                 


Thr Ala Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile Pro Phe 
865                 870                 875                 880 


Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln Asn 
                885                 890                 895     


Val Leu Tyr Glu Asn Gln Lys Gln Ile Ala Asn Gln Phe Asn Lys Ala 
            900                 905                 910         


Ile Ser Gln Ile Gln Glu Ser Leu Thr Thr Thr Ser Thr Ala Leu Gly 
        915                 920                 925             


Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn Thr Leu 
    930                 935                 940                 


Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val Leu Asn 
945                 950                 955                 960 


Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln Ile Asp 
                965                 970                 975     


Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln Thr Tyr Val Thr Gln 
            980                 985                 990         


Gln Leu Ile Arg Ala Ala Glu Ile  Arg Ala Ser Ala Asn  Leu Ala Ala 
        995                 1000                 1005             


Thr Lys  Met Ser Glu Cys Val  Leu Gly Gln Ser Lys  Arg Val Asp 
    1010                 1015                 1020             


Phe Cys  Gly Lys Gly Tyr His  Leu Met Ser Phe Pro  Gln Ala Ala 
    1025                 1030                 1035             


Pro His  Gly Val Val Phe Leu  His Val Thr Tyr Val  Pro Ser Gln 
    1040                 1045                 1050             


Glu Arg  Asn Phe Thr Thr Ala  Pro Ala Ile Cys His  Glu Gly Lys 
    1055                 1060                 1065             


Ala Tyr  Phe Pro Arg Glu Gly  Val Phe Val Phe Asn  Gly Thr Ser 
    1070                 1075                 1080             


Trp Phe  Ile Thr Gln Arg Asn  Phe Phe Ser Pro Gln  Ile Ile Thr 
    1085                 1090                 1095             


Thr Asp  Asn Thr Phe Val Ser  Gly Asn Cys Asp Val  Val Ile Gly 
    1100                 1105                 1110             


Ile Ile  Asn Asn Thr Val Tyr  Asp Pro Leu Gln Pro  Glu Leu Asp 
    1115                 1120                 1125             


Ser Phe  Lys Gly Glu Leu Asp  Lys Tyr Phe Lys Asn  His Thr Ser 
    1130                 1135                 1140             


Pro Asp  Val Asp Leu Gly Asp  Ile Ser Gly Ile Asn  Ala Ser Val 
    1145                 1150                 1155             


Val Asn  Ile Gln Lys Glu Ile  Asp Arg Leu Asn Glu  Val Ala Lys 
    1160                 1165                 1170             


Asn Leu  Asn Glu Ser Leu Ile  Asp Leu Gln Glu Leu  Gly Lys Tyr 
    1175                 1180                 1185             


Glu Gln  Tyr Ile Lys Trp Pro  Trp Tyr Val Trp Leu  Gly Phe Ile 
    1190                 1195                 1200             


Ala Gly  Leu Ile Ala Ile Val  Met Val Thr Ile Leu  Leu Cys Cys 
    1205                 1210                 1215             


Met Thr  Ser Cys Cys Ser Cys  Leu Lys Gly Ala Cys  Ser Cys Gly 
    1220                 1225                 1230             


Ser Cys  Cys Lys Phe Asp Glu  Asp Asp Ser Glu Pro  Val Leu Lys 
    1235                 1240                 1245             


Gly Val  Lys Leu His Tyr Thr  
    1250                 1255 


<210>  7
<211>  2544
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chimeric protein that includes the S1 subunit of Middle East 
       Respiratory Syndrome Coronavirus rused to a C-terminal part of 
       Rabies virus G glycoprotein (amino acids 428-524)

<400>  7
atgattcact ctgtgttcct gctgatgttc ctgctgacac caacagagtc ctatgtggat       60

gtgggacctg actctgtgaa gtctgcctgt attgaggtgg acatccaaca gaccttcttt      120

gacaagacct ggccaagacc aattgatgtg agcaaggctg atggcatcat ctacccacag      180

ggcaggacct acagcaacat caccatcacc taccagggac tgtttccata ccagggagat      240

catggagata tgtatgtcta ctctgctggt catgccacag gcaccacacc acagaaactg      300

tttgtggcta actacagcca ggatgtgaag cagtttgcca atggctttgt ggtgaggatt      360

ggagcagcag ccaacagcac aggcacagtg attatcagcc caagcacctc tgccaccatc      420

aggaagattt accctgcctt tatgctgggc tcctctgtgg gcaacttctc tgatggcaag      480

atgggcaggt tcttcaacca caccctggtg ctgctgcctg atggctgtgg caccctgctg      540

agggctttct actgtatctt ggaaccaagg tctggcaacc actgtcctgc tggcaactcc      600

tacacctcct ttgccaccta ccacacacct gccacagact gttctgatgg caactacaac      660

aggaatgcct ccctgaactc cttcaaggaa tacttcaacc tgaggaactg tacctttatg      720

tacacctaca acatcacaga ggatgagatt ttggagtggt ttggcatcac ccagacagcc      780

cagggagtgc atctgttctc gagcagatat gtggacctct atggaggcaa tatgttccag      840

tttgccaccc tgcctgtcta tgacaccatc aaatactaca gcatcatccc acacagcatc      900

aggagcatcc agtctgacag gaaggcttgg gctgccttct atgtctacaa actccaacca      960

ctgaccttcc tgctggactt ctctgtggat ggctacatca ggagggctat tgactgtggc     1020

ttcaatgacc tgagccaact tcactgttcc tatgagtcct ttgatgtgga gtctggagtc     1080

tactctgtgt cctcctttga ggctaagcca tctggctctg tggtggaaca ggctgaggga     1140

gtggagtgtg acttcagccc actgctgtct ggcacacctc cacaggtcta caacttcaag     1200

agactggtgt tcaccaactg taactacaac ctgaccaaac tgctgtccct gttctctgtg     1260

aatgacttca cttgtagcca gattagccct gctgccattg ccagcaactg ttactcctcc     1320

ctgattctgg actacttctc ctacccactg agtatgaagt ctgacctgtc tgtgtcctct     1380

gctggaccaa tcagccagtt caactacaag cagtccttca gcaacccaac ttgtctgatt     1440

ctggctacag tgccacacaa cctgaccacc atcaccaagc cactgaaata ctcctacatc     1500

aacaagtgta gcagactgct gtctgatgac aggacagagg tgccacaact agtgaatgcc     1560

aaccaataca gcccatgtgt gagcattgtg ccaagcacag tgtgggagga tggagactac     1620

tacaggaagc aacttagccc attggaggga ggaggctggc tggtggcatc tggcagcaca     1680

gtggctatga cagaacaact ccaaatgggc tttggcatca cagtccaata tggcacagac     1740

accaactctg tgtgtccaaa attggagttt gccaatgaca ccaagattgc cagccaactt     1800

ggcaactgtg tggaatactc cctctatgga gtgtctggca ggggagtgtt ccagaactgt     1860

actgctgtgg gagtgagaca acagaggttt gtctatgatg cctaccagaa cctggtgggc     1920

tactactctg atgatggcaa ctactactgt ctgagggctt gtgtgtctgt gcctgtgtct     1980

gtgatttatg acaaggagac caagacccat gccaccctgt ttggctctgt ggcttgtgaa     2040

cacatctcca gcacaatgag tcaatacagc aggagcacca ggagtatgct gaaaaggagg     2100

gacagcacat atggaccact ccaaacacct gtgggctgtg tgctgggact ggtgaactcc     2160

tccctgtttg tggaggactg taaactgcca ctgggacaat ccctgtgtgc cctgcctgac     2220

acaccaagca ccctgacacc aaggtctgtg ggagatgagg ccgaagactt tgtggaagtc     2280

cacctgcctg atgtgcataa ccaggtgtct ggcgtcgacc tgggactgcc aaattggggc     2340

aagtacgtgc tgctgagtgc tggagcactg actgccctga tgctgatcat tttcctgatg     2400

acctgctgtc ggcgcgtgaa cagaagtgag cccactcagc acaatctgcg aggaaccggg     2460

agagaagtgt cagtcacacc tcagagcggg aaaatcatta gtagttggga atcacataaa     2520

agcgggggcg agaccaggct gtga                                            2544


<210>  8
<211>  847
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric protein that includes the S1 subunit of Middle East 
       Respiratory Syndrome Coronavirus rused to a C-terminal part of 
       Rabies virus G glycoprotein (amino acids 428-524)

<400>  8

Met Ile His Ser Val Phe Leu Leu Met Phe Leu Leu Thr Pro Thr Glu 
1               5                   10                  15      


Ser Tyr Val Asp Val Gly Pro Asp Ser Val Lys Ser Ala Cys Ile Glu 
            20                  25                  30          


Val Asp Ile Gln Gln Thr Phe Phe Asp Lys Thr Trp Pro Arg Pro Ile 
        35                  40                  45              


Asp Val Ser Lys Ala Asp Gly Ile Ile Tyr Pro Gln Gly Arg Thr Tyr 
    50                  55                  60                  


Ser Asn Ile Thr Ile Thr Tyr Gln Gly Leu Phe Pro Tyr Gln Gly Asp 
65                  70                  75                  80  


His Gly Asp Met Tyr Val Tyr Ser Ala Gly His Ala Thr Gly Thr Thr 
                85                  90                  95      


Pro Gln Lys Leu Phe Val Ala Asn Tyr Ser Gln Asp Val Lys Gln Phe 
            100                 105                 110         


Ala Asn Gly Phe Val Val Arg Ile Gly Ala Ala Ala Asn Ser Thr Gly 
        115                 120                 125             


Thr Val Ile Ile Ser Pro Ser Thr Ser Ala Thr Ile Arg Lys Ile Tyr 
    130                 135                 140                 


Pro Ala Phe Met Leu Gly Ser Ser Val Gly Asn Phe Ser Asp Gly Lys 
145                 150                 155                 160 


Met Gly Arg Phe Phe Asn His Thr Leu Val Leu Leu Pro Asp Gly Cys 
                165                 170                 175     


Gly Thr Leu Leu Arg Ala Phe Tyr Cys Ile Leu Glu Pro Arg Ser Gly 
            180                 185                 190         


Asn His Cys Pro Ala Gly Asn Ser Tyr Thr Ser Phe Ala Thr Tyr His 
        195                 200                 205             


Thr Pro Ala Thr Asp Cys Ser Asp Gly Asn Tyr Asn Arg Asn Ala Ser 
    210                 215                 220                 


Leu Asn Ser Phe Lys Glu Tyr Phe Asn Leu Arg Asn Cys Thr Phe Met 
225                 230                 235                 240 


Tyr Thr Tyr Asn Ile Thr Glu Asp Glu Ile Leu Glu Trp Phe Gly Ile 
                245                 250                 255     


Thr Gln Thr Ala Gln Gly Val His Leu Phe Ser Ser Arg Tyr Val Asp 
            260                 265                 270         


Leu Tyr Gly Gly Asn Met Phe Gln Phe Ala Thr Leu Pro Val Tyr Asp 
        275                 280                 285             


Thr Ile Lys Tyr Tyr Ser Ile Ile Pro His Ser Ile Arg Ser Ile Gln 
    290                 295                 300                 


Ser Asp Arg Lys Ala Trp Ala Ala Phe Tyr Val Tyr Lys Leu Gln Pro 
305                 310                 315                 320 


Leu Thr Phe Leu Leu Asp Phe Ser Val Asp Gly Tyr Ile Arg Arg Ala 
                325                 330                 335     


Ile Asp Cys Gly Phe Asn Asp Leu Ser Gln Leu His Cys Ser Tyr Glu 
            340                 345                 350         


Ser Phe Asp Val Glu Ser Gly Val Tyr Ser Val Ser Ser Phe Glu Ala 
        355                 360                 365             


Lys Pro Ser Gly Ser Val Val Glu Gln Ala Glu Gly Val Glu Cys Asp 
    370                 375                 380                 


Phe Ser Pro Leu Leu Ser Gly Thr Pro Pro Gln Val Tyr Asn Phe Lys 
385                 390                 395                 400 


Arg Leu Val Phe Thr Asn Cys Asn Tyr Asn Leu Thr Lys Leu Leu Ser 
                405                 410                 415     


Leu Phe Ser Val Asn Asp Phe Thr Cys Ser Gln Ile Ser Pro Ala Ala 
            420                 425                 430         


Ile Ala Ser Asn Cys Tyr Ser Ser Leu Ile Leu Asp Tyr Phe Ser Tyr 
        435                 440                 445             


Pro Leu Ser Met Lys Ser Asp Leu Ser Val Ser Ser Ala Gly Pro Ile 
    450                 455                 460                 


Ser Gln Phe Asn Tyr Lys Gln Ser Phe Ser Asn Pro Thr Cys Leu Ile 
465                 470                 475                 480 


Leu Ala Thr Val Pro His Asn Leu Thr Thr Ile Thr Lys Pro Leu Lys 
                485                 490                 495     


Tyr Ser Tyr Ile Asn Lys Cys Ser Arg Leu Leu Ser Asp Asp Arg Thr 
            500                 505                 510         


Glu Val Pro Gln Leu Val Asn Ala Asn Gln Tyr Ser Pro Cys Val Ser 
        515                 520                 525             


Ile Val Pro Ser Thr Val Trp Glu Asp Gly Asp Tyr Tyr Arg Lys Gln 
    530                 535                 540                 


Leu Ser Pro Leu Glu Gly Gly Gly Trp Leu Val Ala Ser Gly Ser Thr 
545                 550                 555                 560 


Val Ala Met Thr Glu Gln Leu Gln Met Gly Phe Gly Ile Thr Val Gln 
                565                 570                 575     


Tyr Gly Thr Asp Thr Asn Ser Val Cys Pro Lys Leu Glu Phe Ala Asn 
            580                 585                 590         


Asp Thr Lys Ile Ala Ser Gln Leu Gly Asn Cys Val Glu Tyr Ser Leu 
        595                 600                 605             


Tyr Gly Val Ser Gly Arg Gly Val Phe Gln Asn Cys Thr Ala Val Gly 
    610                 615                 620                 


Val Arg Gln Gln Arg Phe Val Tyr Asp Ala Tyr Gln Asn Leu Val Gly 
625                 630                 635                 640 


Tyr Tyr Ser Asp Asp Gly Asn Tyr Tyr Cys Leu Arg Ala Cys Val Ser 
                645                 650                 655     


Val Pro Val Ser Val Ile Tyr Asp Lys Glu Thr Lys Thr His Ala Thr 
            660                 665                 670         


Leu Phe Gly Ser Val Ala Cys Glu His Ile Ser Ser Thr Met Ser Gln 
        675                 680                 685             


Tyr Ser Arg Ser Thr Arg Ser Met Leu Lys Arg Arg Asp Ser Thr Tyr 
    690                 695                 700                 


Gly Pro Leu Gln Thr Pro Val Gly Cys Val Leu Gly Leu Val Asn Ser 
705                 710                 715                 720 


Ser Leu Phe Val Glu Asp Cys Lys Leu Pro Leu Gly Gln Ser Leu Cys 
                725                 730                 735     


Ala Leu Pro Asp Thr Pro Ser Thr Leu Thr Pro Arg Ser Val Gly Asp 
            740                 745                 750         


Glu Ala Glu Asp Phe Val Glu Val His Leu Pro Asp Val His Asn Gln 
        755                 760                 765             


Val Ser Gly Val Asp Leu Gly Leu Pro Asn Trp Gly Lys Tyr Val Leu 
    770                 775                 780                 


Leu Ser Ala Gly Ala Leu Thr Ala Leu Met Leu Ile Ile Phe Leu Met 
785                 790                 795                 800 


Thr Cys Cys Arg Arg Val Asn Arg Ser Glu Pro Thr Gln His Asn Leu 
                805                 810                 815     


Arg Gly Thr Gly Arg Glu Val Ser Val Thr Pro Gln Ser Gly Lys Ile 
            820                 825                 830         


Ile Ser Ser Trp Glu Ser His Lys Ser Gly Gly Glu Thr Arg Leu 
        835                 840                 845         


<210>  9
<211>  4062
<212>  DNA
<213>  Middle East Respiratory Syndrome Coronavirus

<400>  9
atgatacact cagtgtttct actgatgttc ttgttaacac ctacagaaag ttacgttgat       60

gtagggccag attctgttaa gtctgcttgt attgaggttg atatacaaca gactttcttt      120

gataaaactt ggcctaggcc aattgatgtt tctaaggctg acggtattat ataccctcaa      180

ggccgtacat attctaacat aactatcact tatcaaggtc tttttcccta tcagggagac      240

catggtgata tgtatgttta ctctgcagga catgctacag gcacaactcc acaaaagttg      300

tttgtagcta actattctca ggacgtcaaa cagtttgcta atgggtttgt cgtccgtata      360

ggagcagctg ccaattccac tggcactgtt attattagcc catctaccag cgctactata      420

cgaaaaattt accctgcttt tatgctgggt tcttcagttg gtaatttctc agatggtaaa      480

atgggccgct tcttcaatca tactctagtt cttttgcccg atggatgtgg cactttactt      540

agagcttttt attgtattct agagcctcgc tctggaaatc attgtcctgc tggcaattcc      600

tatacttctt ttgccactta tcacactcct gcaacagatt gttctgatgg caattacaat      660

cgtaatgcca gtctgaactc ttttaaggag tattttaatt tacgtaactg cacctttatg      720

tacacttata acattaccga agatgagatt ttagagtggt ttggcattac acaaactgct      780

caaggtgttc acctcttctc atctcggtat gttgatttgt acggcggcaa tatgtttcaa      840

tttgccacct tgcctgttta tgatactatt aagtattatt ctatcattcc tcacagtatt      900

cgttctatcc aaagtgatag aaaagcttgg gctgccttct acgtatataa acttcaaccg      960

ttaactttcc tgttggattt ttctgttgat ggttatatac gcagagctat agactgtggt     1020

tttaatgatt tgtcacaact ccactgctca tatgaatcct tcgatgttga atctggagtt     1080

tattcagttt cgtctttcga agcaaaacct tctggctcag ttgtggaaca ggctgaaggt     1140

gttgaatgtg atttttcacc tcttctgtct ggcacacctc ctcaggttta taatttcaag     1200

cgtttggttt ttaccaattg caattataat cttaccaaat tgctttcact tttttctgtg     1260

aatgatttta cttgtagtca aatatctcca gcagcaattg ctagcaactg ttattcttca     1320

ctgattttgg attacttttc atacccactt agtatgaaat ccgatctcag tgttagttct     1380

gctggtccaa tatcccagtt taattataaa cagtcctttt ctaatcccac atgtttgatt     1440

ttagcgactg ttcctcataa ccttactact attactaagc ctcttaagta cagctatatt     1500

aacaagtgct ctcgtcttct ttctgatgat cgtactgaag tacctcagtt agtgaacgct     1560

aatcaatact caccctgtgt atccattgtc ccatccactg tgtgggaaga cggtgattat     1620

tataggaaac aactatctcc acttgaaggt ggtggctggc ttgttgctag tggctcaact     1680

gttgccatga ctgagcaatt acagatgggc tttggtatta cagttcaata tggtacagac     1740

accaatagtg tttgccccaa gcttgaattt gctaatgaca caaaaattgc ctctcaatta     1800

ggcaattgcg tggaatattc cctctatggt gtttcgggcc gtggtgtttt tcagaattgc     1860

acagctgtag gtgttcgaca gcagcgcttt gtttatgatg cgtaccagaa tttagttggc     1920

tattattctg atgatggcaa ctactactgt ttgcgtgctt gtgttagtgt tcctgtttct     1980

gtcatctatg ataaagaaac taaaacccac gctactctat ttggtagtgt tgcatgtgaa     2040

cacatttctt ctaccatgtc tcaatactcc cgttctacgc gatcaatgct taaacggcga     2100

gattctacat atggccccct tcagacacct gttggttgtg tcctaggact tgttaattcc     2160

tctttgttcg tagaggactg caagttgcct cttggtcaat ctctctgtgc tcttcctgac     2220

acacctagta ctctcacacc tcgcagtgtg cgctctgttc caggtgaaat gcgcttggca     2280

tccattgctt ttaatcatcc tattcaggtt gatcaactta atagtagtta ttttaaatta     2340

agtataccca ctaatttttc ctttggtgtg actcaggagt acattcagac aaccattcag     2400

aaagttactg ttgattgtaa acagtacgtt tgcaatggtt tccagaagtg tgagcaatta     2460

ctgcgcgagt atggccagtt ttgttccaaa ataaaccagg ctctccatgg tgccaattta     2520

cgccaggatg attctgtacg taatttgttt gcgagcgtga aaagctctca atcatctcct     2580

atcataccag gttttggagg tgactttaat ttgacacttc tagaacctgt ttctatatct     2640

actggcagtc gtagtgcacg tagtgctatt gaggatttgc tatttgacaa agtcactata     2700

gctgatcctg gttatatgca aggttacgat gattgcatgc agcaaggtcc agcatcagct     2760

cgtgatctta tttgtgctca atatgtggct ggttacaaag tattacctcc tcttatggat     2820

gttaatatgg aagccgcgta tacttcatct ttgcttggca gcatagcagg tgttggctgg     2880

actgctggct tatcctcctt tgctgctatt ccatttgcac agagtatctt ttataggtta     2940

aacggtgttg gcattactca acaggttctt tcagagaacc aaaagcttat tgccaataag     3000

tttaatcagg ctctgggagc tatgcaaaca ggcttcacta caactaatga agcttttcag     3060

aaggttcagg atgctgtgaa caacaatgca caggctctat ccaaattagc tagcgagcta     3120

tctaatactt ttggtgctat ttccgcctct attggagaca tcatacaacg tcttgatgtt     3180

ctcgaacagg acgcccaaat agacagactt attaatggcc gtttgacaac actaaatgct     3240

tttgttgcac agcagcttgt tcgttccgaa tcagctgctc tttccgctca attggctaaa     3300

gataaagtca atgagtgtgt caaggcacaa tccaagcgtt ctggattttg cggtcaaggc     3360

acacatatag tgtcctttgt tgtaaatgcc cctaatggcc tttacttcat gcatgttggt     3420

tattacccta gcaaccacat tgaggttgtt tctgcttatg gtctttgcga tgcagctaac     3480

cctactaatt gtatagcccc tgttaatggc tactttatta aaactaataa cactaggatt     3540

gttgatgagt ggtcatatac tggctcgtcc ttctatgcac ctgagcccat tacctccctt     3600

aatactaagt atgttgcacc acaggtgaca taccaaaaca tttctactaa cctccctcct     3660

cctcttctcg gcaattccac cgggattgac ttccaagatg agttggatga gtttttcaaa     3720

aatgttagca ccagtatacc taattttggt tccctaacac agattaatac tacattactc     3780

gatcttacct acgagatgtt gtctcttcaa caagttgtta aagcccttaa tgagtcttac     3840

atagacctta aagagcttgg caattatact tattacaaca aatggccgtg gtacatttgg     3900

cttggtttca ttgctgggct tgttgcctta gctctatgcg tcttcttcat actgtgctgc     3960

actggttgtg gcacaaactg tatgggaaaa cttaagtgta atcgttgttg tgatagatac     4020

gaggaatacg acctcgagcc gcataaggtt catgttcact aa                        4062


<210>  10
<211>  1353
<212>  PRT
<213>  Middle East Respiratory Syndrome Coronavirus

<400>  10

Met Ile His Ser Val Phe Leu Leu Met Phe Leu Leu Thr Pro Thr Glu 
1               5                   10                  15      


Ser Tyr Val Asp Val Gly Pro Asp Ser Val Lys Ser Ala Cys Ile Glu 
            20                  25                  30          


Val Asp Ile Gln Gln Thr Phe Phe Asp Lys Thr Trp Pro Arg Pro Ile 
        35                  40                  45              


Asp Val Ser Lys Ala Asp Gly Ile Ile Tyr Pro Gln Gly Arg Thr Tyr 
    50                  55                  60                  


Ser Asn Ile Thr Ile Thr Tyr Gln Gly Leu Phe Pro Tyr Gln Gly Asp 
65                  70                  75                  80  


His Gly Asp Met Tyr Val Tyr Ser Ala Gly His Ala Thr Gly Thr Thr 
                85                  90                  95      


Pro Gln Lys Leu Phe Val Ala Asn Tyr Ser Gln Asp Val Lys Gln Phe 
            100                 105                 110         


Ala Asn Gly Phe Val Val Arg Ile Gly Ala Ala Ala Asn Ser Thr Gly 
        115                 120                 125             


Thr Val Ile Ile Ser Pro Ser Thr Ser Ala Thr Ile Arg Lys Ile Tyr 
    130                 135                 140                 


Pro Ala Phe Met Leu Gly Ser Ser Val Gly Asn Phe Ser Asp Gly Lys 
145                 150                 155                 160 


Met Gly Arg Phe Phe Asn His Thr Leu Val Leu Leu Pro Asp Gly Cys 
                165                 170                 175     


Gly Thr Leu Leu Arg Ala Phe Tyr Cys Ile Leu Glu Pro Arg Ser Gly 
            180                 185                 190         


Asn His Cys Pro Ala Gly Asn Ser Tyr Thr Ser Phe Ala Thr Tyr His 
        195                 200                 205             


Thr Pro Ala Thr Asp Cys Ser Asp Gly Asn Tyr Asn Arg Asn Ala Ser 
    210                 215                 220                 


Leu Asn Ser Phe Lys Glu Tyr Phe Asn Leu Arg Asn Cys Thr Phe Met 
225                 230                 235                 240 


Tyr Thr Tyr Asn Ile Thr Glu Asp Glu Ile Leu Glu Trp Phe Gly Ile 
                245                 250                 255     


Thr Gln Thr Ala Gln Gly Val His Leu Phe Ser Ser Arg Tyr Val Asp 
            260                 265                 270         


Leu Tyr Gly Gly Asn Met Phe Gln Phe Ala Thr Leu Pro Val Tyr Asp 
        275                 280                 285             


Thr Ile Lys Tyr Tyr Ser Ile Ile Pro His Ser Ile Arg Ser Ile Gln 
    290                 295                 300                 


Ser Asp Arg Lys Ala Trp Ala Ala Phe Tyr Val Tyr Lys Leu Gln Pro 
305                 310                 315                 320 


Leu Thr Phe Leu Leu Asp Phe Ser Val Asp Gly Tyr Ile Arg Arg Ala 
                325                 330                 335     


Ile Asp Cys Gly Phe Asn Asp Leu Ser Gln Leu His Cys Ser Tyr Glu 
            340                 345                 350         


Ser Phe Asp Val Glu Ser Gly Val Tyr Ser Val Ser Ser Phe Glu Ala 
        355                 360                 365             


Lys Pro Ser Gly Ser Val Val Glu Gln Ala Glu Gly Val Glu Cys Asp 
    370                 375                 380                 


Phe Ser Pro Leu Leu Ser Gly Thr Pro Pro Gln Val Tyr Asn Phe Lys 
385                 390                 395                 400 


Arg Leu Val Phe Thr Asn Cys Asn Tyr Asn Leu Thr Lys Leu Leu Ser 
                405                 410                 415     


Leu Phe Ser Val Asn Asp Phe Thr Cys Ser Gln Ile Ser Pro Ala Ala 
            420                 425                 430         


Ile Ala Ser Asn Cys Tyr Ser Ser Leu Ile Leu Asp Tyr Phe Ser Tyr 
        435                 440                 445             


Pro Leu Ser Met Lys Ser Asp Leu Ser Val Ser Ser Ala Gly Pro Ile 
    450                 455                 460                 


Ser Gln Phe Asn Tyr Lys Gln Ser Phe Ser Asn Pro Thr Cys Leu Ile 
465                 470                 475                 480 


Leu Ala Thr Val Pro His Asn Leu Thr Thr Ile Thr Lys Pro Leu Lys 
                485                 490                 495     


Tyr Ser Tyr Ile Asn Lys Cys Ser Arg Leu Leu Ser Asp Asp Arg Thr 
            500                 505                 510         


Glu Val Pro Gln Leu Val Asn Ala Asn Gln Tyr Ser Pro Cys Val Ser 
        515                 520                 525             


Ile Val Pro Ser Thr Val Trp Glu Asp Gly Asp Tyr Tyr Arg Lys Gln 
    530                 535                 540                 


Leu Ser Pro Leu Glu Gly Gly Gly Trp Leu Val Ala Ser Gly Ser Thr 
545                 550                 555                 560 


Val Ala Met Thr Glu Gln Leu Gln Met Gly Phe Gly Ile Thr Val Gln 
                565                 570                 575     


Tyr Gly Thr Asp Thr Asn Ser Val Cys Pro Lys Leu Glu Phe Ala Asn 
            580                 585                 590         


Asp Thr Lys Ile Ala Ser Gln Leu Gly Asn Cys Val Glu Tyr Ser Leu 
        595                 600                 605             


Tyr Gly Val Ser Gly Arg Gly Val Phe Gln Asn Cys Thr Ala Val Gly 
    610                 615                 620                 


Val Arg Gln Gln Arg Phe Val Tyr Asp Ala Tyr Gln Asn Leu Val Gly 
625                 630                 635                 640 


Tyr Tyr Ser Asp Asp Gly Asn Tyr Tyr Cys Leu Arg Ala Cys Val Ser 
                645                 650                 655     


Val Pro Val Ser Val Ile Tyr Asp Lys Glu Thr Lys Thr His Ala Thr 
            660                 665                 670         


Leu Phe Gly Ser Val Ala Cys Glu His Ile Ser Ser Thr Met Ser Gln 
        675                 680                 685             


Tyr Ser Arg Ser Thr Arg Ser Met Leu Lys Arg Arg Asp Ser Thr Tyr 
    690                 695                 700                 


Gly Pro Leu Gln Thr Pro Val Gly Cys Val Leu Gly Leu Val Asn Ser 
705                 710                 715                 720 


Ser Leu Phe Val Glu Asp Cys Lys Leu Pro Leu Gly Gln Ser Leu Cys 
                725                 730                 735     


Ala Leu Pro Asp Thr Pro Ser Thr Leu Thr Pro Arg Ser Val Arg Ser 
            740                 745                 750         


Val Pro Gly Glu Met Arg Leu Ala Ser Ile Ala Phe Asn His Pro Ile 
        755                 760                 765             


Gln Val Asp Gln Leu Asn Ser Ser Tyr Phe Lys Leu Ser Ile Pro Thr 
    770                 775                 780                 


Asn Phe Ser Phe Gly Val Thr Gln Glu Tyr Ile Gln Thr Thr Ile Gln 
785                 790                 795                 800 


Lys Val Thr Val Asp Cys Lys Gln Tyr Val Cys Asn Gly Phe Gln Lys 
                805                 810                 815     


Cys Glu Gln Leu Leu Arg Glu Tyr Gly Gln Phe Cys Ser Lys Ile Asn 
            820                 825                 830         


Gln Ala Leu His Gly Ala Asn Leu Arg Gln Asp Asp Ser Val Arg Asn 
        835                 840                 845             


Leu Phe Ala Ser Val Lys Ser Ser Gln Ser Ser Pro Ile Ile Pro Gly 
    850                 855                 860                 


Phe Gly Gly Asp Phe Asn Leu Thr Leu Leu Glu Pro Val Ser Ile Ser 
865                 870                 875                 880 


Thr Gly Ser Arg Ser Ala Arg Ser Ala Ile Glu Asp Leu Leu Phe Asp 
                885                 890                 895     


Lys Val Thr Ile Ala Asp Pro Gly Tyr Met Gln Gly Tyr Asp Asp Cys 
            900                 905                 910         


Met Gln Gln Gly Pro Ala Ser Ala Arg Asp Leu Ile Cys Ala Gln Tyr 
        915                 920                 925             


Val Ala Gly Tyr Lys Val Leu Pro Pro Leu Met Asp Val Asn Met Glu 
    930                 935                 940                 


Ala Ala Tyr Thr Ser Ser Leu Leu Gly Ser Ile Ala Gly Val Gly Trp 
945                 950                 955                 960 


Thr Ala Gly Leu Ser Ser Phe Ala Ala Ile Pro Phe Ala Gln Ser Ile 
                965                 970                 975     


Phe Tyr Arg Leu Asn Gly Val Gly Ile Thr Gln Gln Val Leu Ser Glu 
            980                 985                 990         


Asn Gln Lys Leu Ile Ala Asn Lys  Phe Asn Gln Ala Leu  Gly Ala Met 
        995                 1000                 1005             


Gln Thr  Gly Phe Thr Thr Thr  Asn Glu Ala Phe Gln  Lys Val Gln 
    1010                 1015                 1020             


Asp Ala  Val Asn Asn Asn Ala  Gln Ala Leu Ser Lys  Leu Ala Ser 
    1025                 1030                 1035             


Glu Leu  Ser Asn Thr Phe Gly  Ala Ile Ser Ala Ser  Ile Gly Asp 
    1040                 1045                 1050             


Ile Ile  Gln Arg Leu Asp Val  Leu Glu Gln Asp Ala  Gln Ile Asp 
    1055                 1060                 1065             


Arg Leu  Ile Asn Gly Arg Leu  Thr Thr Leu Asn Ala  Phe Val Ala 
    1070                 1075                 1080             


Gln Gln  Leu Val Arg Ser Glu  Ser Ala Ala Leu Ser  Ala Gln Leu 
    1085                 1090                 1095             


Ala Lys  Asp Lys Val Asn Glu  Cys Val Lys Ala Gln  Ser Lys Arg 
    1100                 1105                 1110             


Ser Gly  Phe Cys Gly Gln Gly  Thr His Ile Val Ser  Phe Val Val 
    1115                 1120                 1125             


Asn Ala  Pro Asn Gly Leu Tyr  Phe Met His Val Gly  Tyr Tyr Pro 
    1130                 1135                 1140             


Ser Asn  His Ile Glu Val Val  Ser Ala Tyr Gly Leu  Cys Asp Ala 
    1145                 1150                 1155             


Ala Asn  Pro Thr Asn Cys Ile  Ala Pro Val Asn Gly  Tyr Phe Ile 
    1160                 1165                 1170             


Lys Thr  Asn Asn Thr Arg Ile  Val Asp Glu Trp Ser  Tyr Thr Gly 
    1175                 1180                 1185             


Ser Ser  Phe Tyr Ala Pro Glu  Pro Ile Thr Ser Leu  Asn Thr Lys 
    1190                 1195                 1200             


Tyr Val  Ala Pro Gln Val Thr  Tyr Gln Asn Ile Ser  Thr Asn Leu 
    1205                 1210                 1215             


Pro Pro  Pro Leu Leu Gly Asn  Ser Thr Gly Ile Asp  Phe Gln Asp 
    1220                 1225                 1230             


Glu Leu  Asp Glu Phe Phe Lys  Asn Val Ser Thr Ser  Ile Pro Asn 
    1235                 1240                 1245             


Phe Gly  Ser Leu Thr Gln Ile  Asn Thr Thr Leu Leu  Asp Leu Thr 
    1250                 1255                 1260             


Tyr Glu  Met Leu Ser Leu Gln  Gln Val Val Lys Ala  Leu Asn Glu 
    1265                 1270                 1275             


Ser Tyr  Ile Asp Leu Lys Glu  Leu Gly Asn Tyr Thr  Tyr Tyr Asn 
    1280                 1285                 1290             


Lys Trp  Pro Trp Tyr Ile Trp  Leu Gly Phe Ile Ala  Gly Leu Val 
    1295                 1300                 1305             


Ala Leu  Ala Leu Cys Val Phe  Phe Ile Leu Cys Cys  Thr Gly Cys 
    1310                 1315                 1320             


Gly Thr  Asn Cys Met Gly Lys  Leu Lys Cys Asn Arg  Cys Cys Asp 
    1325                 1330                 1335             


Arg Tyr  Glu Glu Tyr Asp Leu  Glu Pro His Lys Val  His Val His 
    1340                 1345                 1350             


<210>  11
<211>  3975
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Middle Easter Respiratory Syndrom Coronavirus spike glycoprotein 
       tuncation - 29 amino acid deleted from the C-terminus

<400>  11
atgatacact cagtgtttct actgatgttc ttgttaacac ctacagaaag ttacgttgat       60

gtagggccag attctgttaa gtctgcttgt attgaggttg atatacaaca gactttcttt      120

gataaaactt ggcctaggcc aattgatgtt tctaaggctg acggtattat ataccctcaa      180

ggccgtacat attctaacat aactatcact tatcaaggtc tttttcccta tcagggagac      240

catggtgata tgtatgttta ctctgcagga catgctacag gcacaactcc acaaaagttg      300

tttgtagcta actattctca ggacgtcaaa cagtttgcta atgggtttgt cgtccgtata      360

ggagcagctg ccaattccac tggcactgtt attattagcc catctaccag cgctactata      420

cgaaaaattt accctgcttt tatgctgggt tcttcagttg gtaatttctc agatggtaaa      480

atgggccgct tcttcaatca tactctagtt cttttgcccg atggatgtgg cactttactt      540

agagcttttt attgtattct agagcctcgc tctggaaatc attgtcctgc tggcaattcc      600

tatacttctt ttgccactta tcacactcct gcaacagatt gttctgatgg caattacaat      660

cgtaatgcca gtctgaactc ttttaaggag tattttaatt tacgtaactg cacctttatg      720

tacacttata acattaccga agatgagatt ttagagtggt ttggcattac acaaactgct      780

caaggtgttc acctcttctc atctcggtat gttgatttgt acggcggcaa tatgtttcaa      840

tttgccacct tgcctgttta tgatactatt aagtattatt ctatcattcc tcacagtatt      900

cgttctatcc aaagtgatag aaaagcttgg gctgccttct acgtatataa acttcaaccg      960

ttaactttcc tgttggattt ttctgttgat ggttatatac gcagagctat agactgtggt     1020

tttaatgatt tgtcacaact ccactgctca tatgaatcct tcgatgttga atctggagtt     1080

tattcagttt cgtctttcga agcaaaacct tctggctcag ttgtggaaca ggctgaaggt     1140

gttgaatgtg atttttcacc tcttctgtct ggcacacctc ctcaggttta taatttcaag     1200

cgtttggttt ttaccaattg caattataat cttaccaaat tgctttcact tttttctgtg     1260

aatgatttta cttgtagtca aatatctcca gcagcaattg ctagcaactg ttattcttca     1320

ctgattttgg attacttttc atacccactt agtatgaaat ccgatctcag tgttagttct     1380

gctggtccaa tatcccagtt taattataaa cagtcctttt ctaatcccac atgtttgatt     1440

ttagcgactg ttcctcataa ccttactact attactaagc ctcttaagta cagctatatt     1500

aacaagtgct ctcgtcttct ttctgatgat cgtactgaag tacctcagtt agtgaacgct     1560

aatcaatact caccctgtgt atccattgtc ccatccactg tgtgggaaga cggtgattat     1620

tataggaaac aactatctcc acttgaaggt ggtggctggc ttgttgctag tggctcaact     1680

gttgccatga ctgagcaatt acagatgggc tttggtatta cagttcaata tggtacagac     1740

accaatagtg tttgccccaa gcttgaattt gctaatgaca caaaaattgc ctctcaatta     1800

ggcaattgcg tggaatattc cctctatggt gtttcgggcc gtggtgtttt tcagaattgc     1860

acagctgtag gtgttcgaca gcagcgcttt gtttatgatg cgtaccagaa tttagttggc     1920

tattattctg atgatggcaa ctactactgt ttgcgtgctt gtgttagtgt tcctgtttct     1980

gtcatctatg ataaagaaac taaaacccac gctactctat ttggtagtgt tgcatgtgaa     2040

cacatttctt ctaccatgtc tcaatactcc cgttctacgc gatcaatgct taaacggcga     2100

gattctacat atggccccct tcagacacct gttggttgtg tcctaggact tgttaattcc     2160

tctttgttcg tagaggactg caagttgcct cttggtcaat ctctctgtgc tcttcctgac     2220

acacctagta ctctcacacc tcgcagtgtg cgctctgttc caggtgaaat gcgcttggca     2280

tccattgctt ttaatcatcc tattcaggtt gatcaactta atagtagtta ttttaaatta     2340

agtataccca ctaatttttc ctttggtgtg actcaggagt acattcagac aaccattcag     2400

aaagttactg ttgattgtaa acagtacgtt tgcaatggtt tccagaagtg tgagcaatta     2460

ctgcgcgagt atggccagtt ttgttccaaa ataaaccagg ctctccatgg tgccaattta     2520

cgccaggatg attctgtacg taatttgttt gcgagcgtga aaagctctca atcatctcct     2580

atcataccag gttttggagg tgactttaat ttgacacttc tagaacctgt ttctatatct     2640

actggcagtc gtagtgcacg tagtgctatt gaggatttgc tatttgacaa agtcactata     2700

gctgatcctg gttatatgca aggttacgat gattgcatgc agcaaggtcc agcatcagct     2760

cgtgatctta tttgtgctca atatgtggct ggttacaaag tattacctcc tcttatggat     2820

gttaatatgg aagccgcgta tacttcatct ttgcttggca gcatagcagg tgttggctgg     2880

actgctggct tatcctcctt tgctgctatt ccatttgcac agagtatctt ttataggtta     2940

aacggtgttg gcattactca acaggttctt tcagagaacc aaaagcttat tgccaataag     3000

tttaatcagg ctctgggagc tatgcaaaca ggcttcacta caactaatga agcttttcag     3060

aaggttcagg atgctgtgaa caacaatgca caggctctat ccaaattagc tagcgagcta     3120

tctaatactt ttggtgctat ttccgcctct attggagaca tcatacaacg tcttgatgtt     3180

ctcgaacagg acgcccaaat agacagactt attaatggcc gtttgacaac actaaatgct     3240

tttgttgcac agcagcttgt tcgttccgaa tcagctgctc tttccgctca attggctaaa     3300

gataaagtca atgagtgtgt caaggcacaa tccaagcgtt ctggattttg cggtcaaggc     3360

acacatatag tgtcctttgt tgtaaatgcc cctaatggcc tttacttcat gcatgttggt     3420

tattacccta gcaaccacat tgaggttgtt tctgcttatg gtctttgcga tgcagctaac     3480

cctactaatt gtatagcccc tgttaatggc tactttatta aaactaataa cactaggatt     3540

gttgatgagt ggtcatatac tggctcgtcc ttctatgcac ctgagcccat tacctccctt     3600

aatactaagt atgttgcacc acaggtgaca taccaaaaca tttctactaa cctccctcct     3660

cctcttctcg gcaattccac cgggattgac ttccaagatg agttggatga gtttttcaaa     3720

aatgttagca ccagtatacc taattttggt tccctaacac agattaatac tacattactc     3780

gatcttacct acgagatgtt gtctcttcaa caagttgtta aagcccttaa tgagtcttac     3840

atagacctta aagagcttgg caattatact tattacaaca aatggccgtg gtacatttgg     3900

cttggtttca ttgctgggct tgttgcctta gctctatgcg tcttcttcat actgtgctgc     3960

actggttgtg gctaa                                                      3975


<210>  12
<211>  1324
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Middle Easter Respiratory Syndrom Coronavirus spike glycoprotein 
       tuncation - 29 amino acid deleted from the C-terminus

<400>  12

Met Ile His Ser Val Phe Leu Leu Met Phe Leu Leu Thr Pro Thr Glu 
1               5                   10                  15      


Ser Tyr Val Asp Val Gly Pro Asp Ser Val Lys Ser Ala Cys Ile Glu 
            20                  25                  30          


Val Asp Ile Gln Gln Thr Phe Phe Asp Lys Thr Trp Pro Arg Pro Ile 
        35                  40                  45              


Asp Val Ser Lys Ala Asp Gly Ile Ile Tyr Pro Gln Gly Arg Thr Tyr 
    50                  55                  60                  


Ser Asn Ile Thr Ile Thr Tyr Gln Gly Leu Phe Pro Tyr Gln Gly Asp 
65                  70                  75                  80  


His Gly Asp Met Tyr Val Tyr Ser Ala Gly His Ala Thr Gly Thr Thr 
                85                  90                  95      


Pro Gln Lys Leu Phe Val Ala Asn Tyr Ser Gln Asp Val Lys Gln Phe 
            100                 105                 110         


Ala Asn Gly Phe Val Val Arg Ile Gly Ala Ala Ala Asn Ser Thr Gly 
        115                 120                 125             


Thr Val Ile Ile Ser Pro Ser Thr Ser Ala Thr Ile Arg Lys Ile Tyr 
    130                 135                 140                 


Pro Ala Phe Met Leu Gly Ser Ser Val Gly Asn Phe Ser Asp Gly Lys 
145                 150                 155                 160 


Met Gly Arg Phe Phe Asn His Thr Leu Val Leu Leu Pro Asp Gly Cys 
                165                 170                 175     


Gly Thr Leu Leu Arg Ala Phe Tyr Cys Ile Leu Glu Pro Arg Ser Gly 
            180                 185                 190         


Asn His Cys Pro Ala Gly Asn Ser Tyr Thr Ser Phe Ala Thr Tyr His 
        195                 200                 205             


Thr Pro Ala Thr Asp Cys Ser Asp Gly Asn Tyr Asn Arg Asn Ala Ser 
    210                 215                 220                 


Leu Asn Ser Phe Lys Glu Tyr Phe Asn Leu Arg Asn Cys Thr Phe Met 
225                 230                 235                 240 


Tyr Thr Tyr Asn Ile Thr Glu Asp Glu Ile Leu Glu Trp Phe Gly Ile 
                245                 250                 255     


Thr Gln Thr Ala Gln Gly Val His Leu Phe Ser Ser Arg Tyr Val Asp 
            260                 265                 270         


Leu Tyr Gly Gly Asn Met Phe Gln Phe Ala Thr Leu Pro Val Tyr Asp 
        275                 280                 285             


Thr Ile Lys Tyr Tyr Ser Ile Ile Pro His Ser Ile Arg Ser Ile Gln 
    290                 295                 300                 


Ser Asp Arg Lys Ala Trp Ala Ala Phe Tyr Val Tyr Lys Leu Gln Pro 
305                 310                 315                 320 


Leu Thr Phe Leu Leu Asp Phe Ser Val Asp Gly Tyr Ile Arg Arg Ala 
                325                 330                 335     


Ile Asp Cys Gly Phe Asn Asp Leu Ser Gln Leu His Cys Ser Tyr Glu 
            340                 345                 350         


Ser Phe Asp Val Glu Ser Gly Val Tyr Ser Val Ser Ser Phe Glu Ala 
        355                 360                 365             


Lys Pro Ser Gly Ser Val Val Glu Gln Ala Glu Gly Val Glu Cys Asp 
    370                 375                 380                 


Phe Ser Pro Leu Leu Ser Gly Thr Pro Pro Gln Val Tyr Asn Phe Lys 
385                 390                 395                 400 


Arg Leu Val Phe Thr Asn Cys Asn Tyr Asn Leu Thr Lys Leu Leu Ser 
                405                 410                 415     


Leu Phe Ser Val Asn Asp Phe Thr Cys Ser Gln Ile Ser Pro Ala Ala 
            420                 425                 430         


Ile Ala Ser Asn Cys Tyr Ser Ser Leu Ile Leu Asp Tyr Phe Ser Tyr 
        435                 440                 445             


Pro Leu Ser Met Lys Ser Asp Leu Ser Val Ser Ser Ala Gly Pro Ile 
    450                 455                 460                 


Ser Gln Phe Asn Tyr Lys Gln Ser Phe Ser Asn Pro Thr Cys Leu Ile 
465                 470                 475                 480 


Leu Ala Thr Val Pro His Asn Leu Thr Thr Ile Thr Lys Pro Leu Lys 
                485                 490                 495     


Tyr Ser Tyr Ile Asn Lys Cys Ser Arg Leu Leu Ser Asp Asp Arg Thr 
            500                 505                 510         


Glu Val Pro Gln Leu Val Asn Ala Asn Gln Tyr Ser Pro Cys Val Ser 
        515                 520                 525             


Ile Val Pro Ser Thr Val Trp Glu Asp Gly Asp Tyr Tyr Arg Lys Gln 
    530                 535                 540                 


Leu Ser Pro Leu Glu Gly Gly Gly Trp Leu Val Ala Ser Gly Ser Thr 
545                 550                 555                 560 


Val Ala Met Thr Glu Gln Leu Gln Met Gly Phe Gly Ile Thr Val Gln 
                565                 570                 575     


Tyr Gly Thr Asp Thr Asn Ser Val Cys Pro Lys Leu Glu Phe Ala Asn 
            580                 585                 590         


Asp Thr Lys Ile Ala Ser Gln Leu Gly Asn Cys Val Glu Tyr Ser Leu 
        595                 600                 605             


Tyr Gly Val Ser Gly Arg Gly Val Phe Gln Asn Cys Thr Ala Val Gly 
    610                 615                 620                 


Val Arg Gln Gln Arg Phe Val Tyr Asp Ala Tyr Gln Asn Leu Val Gly 
625                 630                 635                 640 


Tyr Tyr Ser Asp Asp Gly Asn Tyr Tyr Cys Leu Arg Ala Cys Val Ser 
                645                 650                 655     


Val Pro Val Ser Val Ile Tyr Asp Lys Glu Thr Lys Thr His Ala Thr 
            660                 665                 670         


Leu Phe Gly Ser Val Ala Cys Glu His Ile Ser Ser Thr Met Ser Gln 
        675                 680                 685             


Tyr Ser Arg Ser Thr Arg Ser Met Leu Lys Arg Arg Asp Ser Thr Tyr 
    690                 695                 700                 


Gly Pro Leu Gln Thr Pro Val Gly Cys Val Leu Gly Leu Val Asn Ser 
705                 710                 715                 720 


Ser Leu Phe Val Glu Asp Cys Lys Leu Pro Leu Gly Gln Ser Leu Cys 
                725                 730                 735     


Ala Leu Pro Asp Thr Pro Ser Thr Leu Thr Pro Arg Ser Val Arg Ser 
            740                 745                 750         


Val Pro Gly Glu Met Arg Leu Ala Ser Ile Ala Phe Asn His Pro Ile 
        755                 760                 765             


Gln Val Asp Gln Leu Asn Ser Ser Tyr Phe Lys Leu Ser Ile Pro Thr 
    770                 775                 780                 


Asn Phe Ser Phe Gly Val Thr Gln Glu Tyr Ile Gln Thr Thr Ile Gln 
785                 790                 795                 800 


Lys Val Thr Val Asp Cys Lys Gln Tyr Val Cys Asn Gly Phe Gln Lys 
                805                 810                 815     


Cys Glu Gln Leu Leu Arg Glu Tyr Gly Gln Phe Cys Ser Lys Ile Asn 
            820                 825                 830         


Gln Ala Leu His Gly Ala Asn Leu Arg Gln Asp Asp Ser Val Arg Asn 
        835                 840                 845             


Leu Phe Ala Ser Val Lys Ser Ser Gln Ser Ser Pro Ile Ile Pro Gly 
    850                 855                 860                 


Phe Gly Gly Asp Phe Asn Leu Thr Leu Leu Glu Pro Val Ser Ile Ser 
865                 870                 875                 880 


Thr Gly Ser Arg Ser Ala Arg Ser Ala Ile Glu Asp Leu Leu Phe Asp 
                885                 890                 895     


Lys Val Thr Ile Ala Asp Pro Gly Tyr Met Gln Gly Tyr Asp Asp Cys 
            900                 905                 910         


Met Gln Gln Gly Pro Ala Ser Ala Arg Asp Leu Ile Cys Ala Gln Tyr 
        915                 920                 925             


Val Ala Gly Tyr Lys Val Leu Pro Pro Leu Met Asp Val Asn Met Glu 
    930                 935                 940                 


Ala Ala Tyr Thr Ser Ser Leu Leu Gly Ser Ile Ala Gly Val Gly Trp 
945                 950                 955                 960 


Thr Ala Gly Leu Ser Ser Phe Ala Ala Ile Pro Phe Ala Gln Ser Ile 
                965                 970                 975     


Phe Tyr Arg Leu Asn Gly Val Gly Ile Thr Gln Gln Val Leu Ser Glu 
            980                 985                 990         


Asn Gln Lys Leu Ile Ala Asn Lys  Phe Asn Gln Ala Leu  Gly Ala Met 
        995                 1000                 1005             


Gln Thr  Gly Phe Thr Thr Thr  Asn Glu Ala Phe Gln  Lys Val Gln 
    1010                 1015                 1020             


Asp Ala  Val Asn Asn Asn Ala  Gln Ala Leu Ser Lys  Leu Ala Ser 
    1025                 1030                 1035             


Glu Leu  Ser Asn Thr Phe Gly  Ala Ile Ser Ala Ser  Ile Gly Asp 
    1040                 1045                 1050             


Ile Ile  Gln Arg Leu Asp Val  Leu Glu Gln Asp Ala  Gln Ile Asp 
    1055                 1060                 1065             


Arg Leu  Ile Asn Gly Arg Leu  Thr Thr Leu Asn Ala  Phe Val Ala 
    1070                 1075                 1080             


Gln Gln  Leu Val Arg Ser Glu  Ser Ala Ala Leu Ser  Ala Gln Leu 
    1085                 1090                 1095             


Ala Lys  Asp Lys Val Asn Glu  Cys Val Lys Ala Gln  Ser Lys Arg 
    1100                 1105                 1110             


Ser Gly  Phe Cys Gly Gln Gly  Thr His Ile Val Ser  Phe Val Val 
    1115                 1120                 1125             


Asn Ala  Pro Asn Gly Leu Tyr  Phe Met His Val Gly  Tyr Tyr Pro 
    1130                 1135                 1140             


Ser Asn  His Ile Glu Val Val  Ser Ala Tyr Gly Leu  Cys Asp Ala 
    1145                 1150                 1155             


Ala Asn  Pro Thr Asn Cys Ile  Ala Pro Val Asn Gly  Tyr Phe Ile 
    1160                 1165                 1170             


Lys Thr  Asn Asn Thr Arg Ile  Val Asp Glu Trp Ser  Tyr Thr Gly 
    1175                 1180                 1185             


Ser Ser  Phe Tyr Ala Pro Glu  Pro Ile Thr Ser Leu  Asn Thr Lys 
    1190                 1195                 1200             


Tyr Val  Ala Pro Gln Val Thr  Tyr Gln Asn Ile Ser  Thr Asn Leu 
    1205                 1210                 1215             


Pro Pro  Pro Leu Leu Gly Asn  Ser Thr Gly Ile Asp  Phe Gln Asp 
    1220                 1225                 1230             


Glu Leu  Asp Glu Phe Phe Lys  Asn Val Ser Thr Ser  Ile Pro Asn 
    1235                 1240                 1245             


Phe Gly  Ser Leu Thr Gln Ile  Asn Thr Thr Leu Leu  Asp Leu Thr 
    1250                 1255                 1260             


Tyr Glu  Met Leu Ser Leu Gln  Gln Val Val Lys Ala  Leu Asn Glu 
    1265                 1270                 1275             


Ser Tyr  Ile Asp Leu Lys Glu  Leu Gly Asn Tyr Thr  Tyr Tyr Asn 
    1280                 1285                 1290             


Lys Trp  Pro Trp Tyr Ile Trp  Leu Gly Phe Ile Ala  Gly Leu Val 
    1295                 1300                 1305             


Ala Leu  Ala Leu Cys Val Phe  Phe Ile Leu Cys Cys  Thr Gly Cys 
    1310                 1315                 1320             


Gly 
    


<210>  13
<211>  4005
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Middle Easter Respiratory Syndrom Coronavirus spike glycoprotein 
       tuncation - 19 amino acid deleted from the C-terminus

<400>  13
atgatacact cagtgtttct actgatgttc ttgttaacac ctacagaaag ttacgttgat       60

gtagggccag attctgttaa gtctgcttgt attgaggttg atatacaaca gactttcttt      120

gataaaactt ggcctaggcc aattgatgtt tctaaggctg acggtattat ataccctcaa      180

ggccgtacat attctaacat aactatcact tatcaaggtc tttttcccta tcagggagac      240

catggtgata tgtatgttta ctctgcagga catgctacag gcacaactcc acaaaagttg      300

tttgtagcta actattctca ggacgtcaaa cagtttgcta atgggtttgt cgtccgtata      360

ggagcagctg ccaattccac tggcactgtt attattagcc catctaccag cgctactata      420

cgaaaaattt accctgcttt tatgctgggt tcttcagttg gtaatttctc agatggtaaa      480

atgggccgct tcttcaatca tactctagtt cttttgcccg atggatgtgg cactttactt      540

agagcttttt attgtattct agagcctcgc tctggaaatc attgtcctgc tggcaattcc      600

tatacttctt ttgccactta tcacactcct gcaacagatt gttctgatgg caattacaat      660

cgtaatgcca gtctgaactc ttttaaggag tattttaatt tacgtaactg cacctttatg      720

tacacttata acattaccga agatgagatt ttagagtggt ttggcattac acaaactgct      780

caaggtgttc acctcttctc atctcggtat gttgatttgt acggcggcaa tatgtttcaa      840

tttgccacct tgcctgttta tgatactatt aagtattatt ctatcattcc tcacagtatt      900

cgttctatcc aaagtgatag aaaagcttgg gctgccttct acgtatataa acttcaaccg      960

ttaactttcc tgttggattt ttctgttgat ggttatatac gcagagctat agactgtggt     1020

tttaatgatt tgtcacaact ccactgctca tatgaatcct tcgatgttga atctggagtt     1080

tattcagttt cgtctttcga agcaaaacct tctggctcag ttgtggaaca ggctgaaggt     1140

gttgaatgtg atttttcacc tcttctgtct ggcacacctc ctcaggttta taatttcaag     1200

cgtttggttt ttaccaattg caattataat cttaccaaat tgctttcact tttttctgtg     1260

aatgatttta cttgtagtca aatatctcca gcagcaattg ctagcaactg ttattcttca     1320

ctgattttgg attacttttc atacccactt agtatgaaat ccgatctcag tgttagttct     1380

gctggtccaa tatcccagtt taattataaa cagtcctttt ctaatcccac atgtttgatt     1440

ttagcgactg ttcctcataa ccttactact attactaagc ctcttaagta cagctatatt     1500

aacaagtgct ctcgtcttct ttctgatgat cgtactgaag tacctcagtt agtgaacgct     1560

aatcaatact caccctgtgt atccattgtc ccatccactg tgtgggaaga cggtgattat     1620

tataggaaac aactatctcc acttgaaggt ggtggctggc ttgttgctag tggctcaact     1680

gttgccatga ctgagcaatt acagatgggc tttggtatta cagttcaata tggtacagac     1740

accaatagtg tttgccccaa gcttgaattt gctaatgaca caaaaattgc ctctcaatta     1800

ggcaattgcg tggaatattc cctctatggt gtttcgggcc gtggtgtttt tcagaattgc     1860

acagctgtag gtgttcgaca gcagcgcttt gtttatgatg cgtaccagaa tttagttggc     1920

tattattctg atgatggcaa ctactactgt ttgcgtgctt gtgttagtgt tcctgtttct     1980

gtcatctatg ataaagaaac taaaacccac gctactctat ttggtagtgt tgcatgtgaa     2040

cacatttctt ctaccatgtc tcaatactcc cgttctacgc gatcaatgct taaacggcga     2100

gattctacat atggccccct tcagacacct gttggttgtg tcctaggact tgttaattcc     2160

tctttgttcg tagaggactg caagttgcct cttggtcaat ctctctgtgc tcttcctgac     2220

acacctagta ctctcacacc tcgcagtgtg cgctctgttc caggtgaaat gcgcttggca     2280

tccattgctt ttaatcatcc tattcaggtt gatcaactta atagtagtta ttttaaatta     2340

agtataccca ctaatttttc ctttggtgtg actcaggagt acattcagac aaccattcag     2400

aaagttactg ttgattgtaa acagtacgtt tgcaatggtt tccagaagtg tgagcaatta     2460

ctgcgcgagt atggccagtt ttgttccaaa ataaaccagg ctctccatgg tgccaattta     2520

cgccaggatg attctgtacg taatttgttt gcgagcgtga aaagctctca atcatctcct     2580

atcataccag gttttggagg tgactttaat ttgacacttc tagaacctgt ttctatatct     2640

actggcagtc gtagtgcacg tagtgctatt gaggatttgc tatttgacaa agtcactata     2700

gctgatcctg gttatatgca aggttacgat gattgcatgc agcaaggtcc agcatcagct     2760

cgtgatctta tttgtgctca atatgtggct ggttacaaag tattacctcc tcttatggat     2820

gttaatatgg aagccgcgta tacttcatct ttgcttggca gcatagcagg tgttggctgg     2880

actgctggct tatcctcctt tgctgctatt ccatttgcac agagtatctt ttataggtta     2940

aacggtgttg gcattactca acaggttctt tcagagaacc aaaagcttat tgccaataag     3000

tttaatcagg ctctgggagc tatgcaaaca ggcttcacta caactaatga agcttttcag     3060

aaggttcagg atgctgtgaa caacaatgca caggctctat ccaaattagc tagcgagcta     3120

tctaatactt ttggtgctat ttccgcctct attggagaca tcatacaacg tcttgatgtt     3180

ctcgaacagg acgcccaaat agacagactt attaatggcc gtttgacaac actaaatgct     3240

tttgttgcac agcagcttgt tcgttccgaa tcagctgctc tttccgctca attggctaaa     3300

gataaagtca atgagtgtgt caaggcacaa tccaagcgtt ctggattttg cggtcaaggc     3360

acacatatag tgtcctttgt tgtaaatgcc cctaatggcc tttacttcat gcatgttggt     3420

tattacccta gcaaccacat tgaggttgtt tctgcttatg gtctttgcga tgcagctaac     3480

cctactaatt gtatagcccc tgttaatggc tactttatta aaactaataa cactaggatt     3540

gttgatgagt ggtcatatac tggctcgtcc ttctatgcac ctgagcccat tacctccctt     3600

aatactaagt atgttgcacc acaggtgaca taccaaaaca tttctactaa cctccctcct     3660

cctcttctcg gcaattccac cgggattgac ttccaagatg agttggatga gtttttcaaa     3720

aatgttagca ccagtatacc taattttggt tccctaacac agattaatac tacattactc     3780

gatcttacct acgagatgtt gtctcttcaa caagttgtta aagcccttaa tgagtcttac     3840

atagacctta aagagcttgg caattatact tattacaaca aatggccgtg gtacatttgg     3900

cttggtttca ttgctgggct tgttgcctta gctctatgcg tcttcttcat actgtgctgc     3960

actggttgtg gcacaaactg tatgggaaaa cttaagtgta attaa                     4005


<210>  14
<211>  1334
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Middle Easter Respiratory Syndrom Coronavirus spike glycoprotein 
       tuncation - 19 amino acid deleted from the C-terminus

<400>  14

Met Ile His Ser Val Phe Leu Leu Met Phe Leu Leu Thr Pro Thr Glu 
1               5                   10                  15      


Ser Tyr Val Asp Val Gly Pro Asp Ser Val Lys Ser Ala Cys Ile Glu 
            20                  25                  30          


Val Asp Ile Gln Gln Thr Phe Phe Asp Lys Thr Trp Pro Arg Pro Ile 
        35                  40                  45              


Asp Val Ser Lys Ala Asp Gly Ile Ile Tyr Pro Gln Gly Arg Thr Tyr 
    50                  55                  60                  


Ser Asn Ile Thr Ile Thr Tyr Gln Gly Leu Phe Pro Tyr Gln Gly Asp 
65                  70                  75                  80  


His Gly Asp Met Tyr Val Tyr Ser Ala Gly His Ala Thr Gly Thr Thr 
                85                  90                  95      


Pro Gln Lys Leu Phe Val Ala Asn Tyr Ser Gln Asp Val Lys Gln Phe 
            100                 105                 110         


Ala Asn Gly Phe Val Val Arg Ile Gly Ala Ala Ala Asn Ser Thr Gly 
        115                 120                 125             


Thr Val Ile Ile Ser Pro Ser Thr Ser Ala Thr Ile Arg Lys Ile Tyr 
    130                 135                 140                 


Pro Ala Phe Met Leu Gly Ser Ser Val Gly Asn Phe Ser Asp Gly Lys 
145                 150                 155                 160 


Met Gly Arg Phe Phe Asn His Thr Leu Val Leu Leu Pro Asp Gly Cys 
                165                 170                 175     


Gly Thr Leu Leu Arg Ala Phe Tyr Cys Ile Leu Glu Pro Arg Ser Gly 
            180                 185                 190         


Asn His Cys Pro Ala Gly Asn Ser Tyr Thr Ser Phe Ala Thr Tyr His 
        195                 200                 205             


Thr Pro Ala Thr Asp Cys Ser Asp Gly Asn Tyr Asn Arg Asn Ala Ser 
    210                 215                 220                 


Leu Asn Ser Phe Lys Glu Tyr Phe Asn Leu Arg Asn Cys Thr Phe Met 
225                 230                 235                 240 


Tyr Thr Tyr Asn Ile Thr Glu Asp Glu Ile Leu Glu Trp Phe Gly Ile 
                245                 250                 255     


Thr Gln Thr Ala Gln Gly Val His Leu Phe Ser Ser Arg Tyr Val Asp 
            260                 265                 270         


Leu Tyr Gly Gly Asn Met Phe Gln Phe Ala Thr Leu Pro Val Tyr Asp 
        275                 280                 285             


Thr Ile Lys Tyr Tyr Ser Ile Ile Pro His Ser Ile Arg Ser Ile Gln 
    290                 295                 300                 


Ser Asp Arg Lys Ala Trp Ala Ala Phe Tyr Val Tyr Lys Leu Gln Pro 
305                 310                 315                 320 


Leu Thr Phe Leu Leu Asp Phe Ser Val Asp Gly Tyr Ile Arg Arg Ala 
                325                 330                 335     


Ile Asp Cys Gly Phe Asn Asp Leu Ser Gln Leu His Cys Ser Tyr Glu 
            340                 345                 350         


Ser Phe Asp Val Glu Ser Gly Val Tyr Ser Val Ser Ser Phe Glu Ala 
        355                 360                 365             


Lys Pro Ser Gly Ser Val Val Glu Gln Ala Glu Gly Val Glu Cys Asp 
    370                 375                 380                 


Phe Ser Pro Leu Leu Ser Gly Thr Pro Pro Gln Val Tyr Asn Phe Lys 
385                 390                 395                 400 


Arg Leu Val Phe Thr Asn Cys Asn Tyr Asn Leu Thr Lys Leu Leu Ser 
                405                 410                 415     


Leu Phe Ser Val Asn Asp Phe Thr Cys Ser Gln Ile Ser Pro Ala Ala 
            420                 425                 430         


Ile Ala Ser Asn Cys Tyr Ser Ser Leu Ile Leu Asp Tyr Phe Ser Tyr 
        435                 440                 445             


Pro Leu Ser Met Lys Ser Asp Leu Ser Val Ser Ser Ala Gly Pro Ile 
    450                 455                 460                 


Ser Gln Phe Asn Tyr Lys Gln Ser Phe Ser Asn Pro Thr Cys Leu Ile 
465                 470                 475                 480 


Leu Ala Thr Val Pro His Asn Leu Thr Thr Ile Thr Lys Pro Leu Lys 
                485                 490                 495     


Tyr Ser Tyr Ile Asn Lys Cys Ser Arg Leu Leu Ser Asp Asp Arg Thr 
            500                 505                 510         


Glu Val Pro Gln Leu Val Asn Ala Asn Gln Tyr Ser Pro Cys Val Ser 
        515                 520                 525             


Ile Val Pro Ser Thr Val Trp Glu Asp Gly Asp Tyr Tyr Arg Lys Gln 
    530                 535                 540                 


Leu Ser Pro Leu Glu Gly Gly Gly Trp Leu Val Ala Ser Gly Ser Thr 
545                 550                 555                 560 


Val Ala Met Thr Glu Gln Leu Gln Met Gly Phe Gly Ile Thr Val Gln 
                565                 570                 575     


Tyr Gly Thr Asp Thr Asn Ser Val Cys Pro Lys Leu Glu Phe Ala Asn 
            580                 585                 590         


Asp Thr Lys Ile Ala Ser Gln Leu Gly Asn Cys Val Glu Tyr Ser Leu 
        595                 600                 605             


Tyr Gly Val Ser Gly Arg Gly Val Phe Gln Asn Cys Thr Ala Val Gly 
    610                 615                 620                 


Val Arg Gln Gln Arg Phe Val Tyr Asp Ala Tyr Gln Asn Leu Val Gly 
625                 630                 635                 640 


Tyr Tyr Ser Asp Asp Gly Asn Tyr Tyr Cys Leu Arg Ala Cys Val Ser 
                645                 650                 655     


Val Pro Val Ser Val Ile Tyr Asp Lys Glu Thr Lys Thr His Ala Thr 
            660                 665                 670         


Leu Phe Gly Ser Val Ala Cys Glu His Ile Ser Ser Thr Met Ser Gln 
        675                 680                 685             


Tyr Ser Arg Ser Thr Arg Ser Met Leu Lys Arg Arg Asp Ser Thr Tyr 
    690                 695                 700                 


Gly Pro Leu Gln Thr Pro Val Gly Cys Val Leu Gly Leu Val Asn Ser 
705                 710                 715                 720 


Ser Leu Phe Val Glu Asp Cys Lys Leu Pro Leu Gly Gln Ser Leu Cys 
                725                 730                 735     


Ala Leu Pro Asp Thr Pro Ser Thr Leu Thr Pro Arg Ser Val Arg Ser 
            740                 745                 750         


Val Pro Gly Glu Met Arg Leu Ala Ser Ile Ala Phe Asn His Pro Ile 
        755                 760                 765             


Gln Val Asp Gln Leu Asn Ser Ser Tyr Phe Lys Leu Ser Ile Pro Thr 
    770                 775                 780                 


Asn Phe Ser Phe Gly Val Thr Gln Glu Tyr Ile Gln Thr Thr Ile Gln 
785                 790                 795                 800 


Lys Val Thr Val Asp Cys Lys Gln Tyr Val Cys Asn Gly Phe Gln Lys 
                805                 810                 815     


Cys Glu Gln Leu Leu Arg Glu Tyr Gly Gln Phe Cys Ser Lys Ile Asn 
            820                 825                 830         


Gln Ala Leu His Gly Ala Asn Leu Arg Gln Asp Asp Ser Val Arg Asn 
        835                 840                 845             


Leu Phe Ala Ser Val Lys Ser Ser Gln Ser Ser Pro Ile Ile Pro Gly 
    850                 855                 860                 


Phe Gly Gly Asp Phe Asn Leu Thr Leu Leu Glu Pro Val Ser Ile Ser 
865                 870                 875                 880 


Thr Gly Ser Arg Ser Ala Arg Ser Ala Ile Glu Asp Leu Leu Phe Asp 
                885                 890                 895     


Lys Val Thr Ile Ala Asp Pro Gly Tyr Met Gln Gly Tyr Asp Asp Cys 
            900                 905                 910         


Met Gln Gln Gly Pro Ala Ser Ala Arg Asp Leu Ile Cys Ala Gln Tyr 
        915                 920                 925             


Val Ala Gly Tyr Lys Val Leu Pro Pro Leu Met Asp Val Asn Met Glu 
    930                 935                 940                 


Ala Ala Tyr Thr Ser Ser Leu Leu Gly Ser Ile Ala Gly Val Gly Trp 
945                 950                 955                 960 


Thr Ala Gly Leu Ser Ser Phe Ala Ala Ile Pro Phe Ala Gln Ser Ile 
                965                 970                 975     


Phe Tyr Arg Leu Asn Gly Val Gly Ile Thr Gln Gln Val Leu Ser Glu 
            980                 985                 990         


Asn Gln Lys Leu Ile Ala Asn Lys  Phe Asn Gln Ala Leu  Gly Ala Met 
        995                 1000                 1005             


Gln Thr  Gly Phe Thr Thr Thr  Asn Glu Ala Phe Gln  Lys Val Gln 
    1010                 1015                 1020             


Asp Ala  Val Asn Asn Asn Ala  Gln Ala Leu Ser Lys  Leu Ala Ser 
    1025                 1030                 1035             


Glu Leu  Ser Asn Thr Phe Gly  Ala Ile Ser Ala Ser  Ile Gly Asp 
    1040                 1045                 1050             


Ile Ile  Gln Arg Leu Asp Val  Leu Glu Gln Asp Ala  Gln Ile Asp 
    1055                 1060                 1065             


Arg Leu  Ile Asn Gly Arg Leu  Thr Thr Leu Asn Ala  Phe Val Ala 
    1070                 1075                 1080             


Gln Gln  Leu Val Arg Ser Glu  Ser Ala Ala Leu Ser  Ala Gln Leu 
    1085                 1090                 1095             


Ala Lys  Asp Lys Val Asn Glu  Cys Val Lys Ala Gln  Ser Lys Arg 
    1100                 1105                 1110             


Ser Gly  Phe Cys Gly Gln Gly  Thr His Ile Val Ser  Phe Val Val 
    1115                 1120                 1125             


Asn Ala  Pro Asn Gly Leu Tyr  Phe Met His Val Gly  Tyr Tyr Pro 
    1130                 1135                 1140             


Ser Asn  His Ile Glu Val Val  Ser Ala Tyr Gly Leu  Cys Asp Ala 
    1145                 1150                 1155             


Ala Asn  Pro Thr Asn Cys Ile  Ala Pro Val Asn Gly  Tyr Phe Ile 
    1160                 1165                 1170             


Lys Thr  Asn Asn Thr Arg Ile  Val Asp Glu Trp Ser  Tyr Thr Gly 
    1175                 1180                 1185             


Ser Ser  Phe Tyr Ala Pro Glu  Pro Ile Thr Ser Leu  Asn Thr Lys 
    1190                 1195                 1200             


Tyr Val  Ala Pro Gln Val Thr  Tyr Gln Asn Ile Ser  Thr Asn Leu 
    1205                 1210                 1215             


Pro Pro  Pro Leu Leu Gly Asn  Ser Thr Gly Ile Asp  Phe Gln Asp 
    1220                 1225                 1230             


Glu Leu  Asp Glu Phe Phe Lys  Asn Val Ser Thr Ser  Ile Pro Asn 
    1235                 1240                 1245             


Phe Gly  Ser Leu Thr Gln Ile  Asn Thr Thr Leu Leu  Asp Leu Thr 
    1250                 1255                 1260             


Tyr Glu  Met Leu Ser Leu Gln  Gln Val Val Lys Ala  Leu Asn Glu 
    1265                 1270                 1275             


Ser Tyr  Ile Asp Leu Lys Glu  Leu Gly Asn Tyr Thr  Tyr Tyr Asn 
    1280                 1285                 1290             


Lys Trp  Pro Trp Tyr Ile Trp  Leu Gly Phe Ile Ala  Gly Leu Val 
    1295                 1300                 1305             


Ala Leu  Ala Leu Cys Val Phe  Phe Ile Leu Cys Cys  Thr Gly Cys 
    1310                 1315                 1320             


Gly Thr  Asn Cys Met Gly Lys  Leu Lys Cys Asn 
    1325                 1330                 


<210>  15
<211>  2123
<212>  DNA
<213>  Rabies virus

<400>  15
aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaactattaa catccctcaa aagacttagg       60

gaaagatggt tccgcaagct cttctgcttg tacccattct gggtttttcc tcgtgtttcg      120

ggaaattccc tatttacacg ataccagaca cacttggtcc ctggagcccg atcgatatac      180

atcatctcag ttgcccaaac aatttggttg tagaggacga aggatgcacc aacctgtcag      240

ggttctccta catggaactt aaagttggac acatctcagc cataaaggtg aacgggttca      300

cttgcacagg cgttgtaaca gaggcagaaa cctacactaa ctttgttggt tatgtcacca      360

ccactttcaa aagaaagcat ttccgcccaa caccagatgc ttgtagagct gcgtacaact      420

ggaagatggc cggtgacccc agatatgaag agtctctaca cagtccgtac cctgactacc      480

attggcttcg aactgtaaaa accacaaagg agtccctcgt tatcatatct ccaagtgtgg      540

tagatttgga cccatatgac aactcccttc actcgagggt cttccctagc ggaaagtgct      600

caggaataac agtatcttct gtctactgct caactaacca cgattacacc gtttggatgc      660

ctgaaagtct gagactaggg acatcttgtg acatttttac caatagtaga gggaagagag      720

tatccaaggg gagcaagacc tgtggctttg tagatgaaag aggcctatat aagtctctaa      780

aaggcgcatg caaactcaag ttgtgtggag ttcgtggact tagacttatg gacggaacat      840

gggtcgcgat gcagacatca aatgagacca aatggtgtcc tcccgatcag ttggttaatc      900

tgcacgacct tcgctcagat gaaatcgagc atcttgttat agaggagttg gtcaagaaaa      960

gagaggagtg tctggatgca ttagagtcca tcataaccac caagtcagtg agtttcagac     1020

gtctcagtta tttaagaaaa cttgtccccg ggttcggaaa agcatatacc atattcaaca     1080

agaccttgat ggaggctgaa gctcactaca agtcagtcag gacttggaat gagatcatcc     1140

cctcaaaagg atgtttgaga gttggaggga ggtgtcatcc tcatgtaaac ggggtgtttt     1200

tcaatggtat aatattaggg cctgacggtc atgttttaat cccagagatg caatcatccc     1260

tcctccagca acatatagag ttattggaat cctcagttat tcccctgatg cacccccttg     1320

cagacccgtt cacagttttc aaggacggcg atgagactga ggattttata gaagttcacc     1380

ttcccgatgt gcacgaacaa gtctcagggg ttgacctggg tctcccgaac tggggggagt     1440

atgtattact aagtgcaggg accttgattg ccttgatgtt gataattttc ctaatgacat     1500

gttgtagaaa agtcgatcgg ccagaatcta cacaacgcag tctcagaggg acaggaagga     1560

atgtgtcagt cacctcccaa agcgggaaat tcataccttc atgggagtcg tataaaagtg     1620

ggggtgagac tggactgtga agatttgtca tcttttcgac gcttcaagtt ctgaagataa     1680

ccttccctct aagctggggg gaatctctga gttcaatagt cctccttgaa ctccattcaa     1740

cagggtggat tcaaaagtca tgagactttc attaatcatc tcagttgatc aaacaaggtc     1800

atgtagattc tcataattcg ggaaatcttc tagtagtttc agtgaccgac agtgctttca     1860

ttccccagga actgatgtca aaggttgttg acgggtcaag aggtatttct gatgactccg     1920

tgcgtgggcc cggacagagg tcatagtacg tcccatgata gcggactcag catgagtcga     1980

ttgagaaaag taatctgcct cccatgaagg acaccggcaa taactcacaa tcatcttgca     2040

tctcagcgaa gtgtgcataa ttataaaggg gctagatcat ctaagctttt cagttgagaa     2100

aaaaaaaaaa aaaaaaaaaa aaa                                             2123


<210>  16
<211>  524
<212>  PRT
<213>  Rabies virus

<400>  16

Met Val Pro Gln Val Leu Leu Phe Ala Pro Leu Leu Val Phe Pro Leu 
1               5                   10                  15      


Cys Phe Gly Lys Phe Pro Ile Tyr Thr Ile Pro Asp Lys Leu Gly Pro 
            20                  25                  30          


Trp Ser Pro Ile Asp Leu His His Leu Ser Cys Pro Asn Asn Leu Val 
        35                  40                  45              


Val Glu Asp Glu Gly Cys Thr Asn Leu Ser Gly Phe Ser Tyr Met Glu 
    50                  55                  60                  


Leu Lys Val Gly Tyr Ile Ser Ala Ile Lys Val Asn Gly Phe Thr Cys 
65                  70                  75                  80  


Thr Gly Val Val Thr Glu Ala Glu Thr Tyr Thr Asn Phe Val Gly Tyr 
                85                  90                  95      


Val Thr Thr Thr Phe Lys Arg Lys His Phe Arg Pro Thr Pro Asp Ala 
            100                 105                 110         


Cys Arg Ala Ala Tyr Asn Trp Lys Met Ala Gly Asp Pro Arg Tyr Glu 
        115                 120                 125             


Glu Ser Leu His Asn Pro Tyr Pro Asp Tyr His Trp Leu Arg Thr Val 
    130                 135                 140                 


Lys Thr Thr Lys Glu Ser Leu Val Ile Ile Ser Pro Ser Val Thr Asp 
145                 150                 155                 160 


Leu Asp Pro Tyr Asp Lys Ser Leu His Ser Arg Val Phe Pro Gly Gly 
                165                 170                 175     


Asn Cys Ser Gly Ile Thr Val Ser Ser Thr Tyr Cys Ser Thr Asn His 
            180                 185                 190         


Asp Tyr Thr Ile Trp Met Pro Glu Asn Leu Arg Leu Gly Thr Ser Cys 
        195                 200                 205             


Asp Ile Phe Thr His Ser Arg Gly Lys Arg Ala Ser Lys Gly Asp Lys 
    210                 215                 220                 


Thr Cys Gly Phe Val Asp Glu Arg Gly Leu Tyr Lys Ser Leu Lys Gly 
225                 230                 235                 240 


Ala Cys Lys Leu Lys Leu Cys Gly Val Leu Gly Leu Arg Leu Met Asp 
                245                 250                 255     


Gly Thr Trp Val Ala Met Gln Thr Ser Asp Glu Thr Lys Trp Cys Pro 
            260                 265                 270         


Pro Gly Gln Leu Val Asn Leu His Asp Phe Arg Ser Asp Glu Ile Glu 
        275                 280                 285             


His Leu Val Glu Glu Glu Leu Val Lys Lys Arg Glu Glu Cys Leu Asp 
    290                 295                 300                 


Ala Leu Glu Ser Ile Met Thr Thr Lys Ser Val Ser Phe Arg Arg Leu 
305                 310                 315                 320 


Ser His Leu Arg Lys Leu Val Pro Gly Phe Gly Lys Ala Tyr Thr Ile 
                325                 330                 335     


Phe Asn Lys Thr Leu Met Glu Ala Asp Ala His Tyr Lys Ser Val Gln 
            340                 345                 350         


Thr Trp Asn Glu Ile Ile Pro Ser Lys Gly Cys Leu Arg Val Gly Glu 
        355                 360                 365             


Arg Cys His Pro His Val Asn Gly Val Phe Phe Asn Gly Ile Ile Leu 
    370                 375                 380                 


Gly Ser Asp Gly His Val Leu Ile Pro Glu Met Gln Ser Ser Leu Leu 
385                 390                 395                 400 


Gln Gln His Met Glu Leu Leu Glu Ser Ser Val Ile Pro Leu Met His 
                405                 410                 415     


Pro Leu Ala Asp Pro Ser Thr Val Phe Lys Asp Gly Asp Glu Val Glu 
            420                 425                 430         


Asp Phe Val Glu Val His Leu Pro Asp Val His Lys Gln Val Ser Gly 
        435                 440                 445             


Val Asp Leu Gly Leu Pro Lys Trp Gly Lys Tyr Val Leu Met Ile Ala 
    450                 455                 460                 


Gly Ala Leu Ile Ala Leu Met Leu Ile Ile Phe Leu Met Thr Cys Cys 
465                 470                 475                 480 


Arg Arg Val Asn Arg Pro Glu Ser Thr Gln Ser Asn Leu Gly Gly Thr 
                485                 490                 495     


Gly Arg Asn Val Ser Val Pro Ser Gln Ser Gly Lys Val Ile Ser Ser 
            500                 505                 510         


Trp Glu Ser Tyr Lys Ser Gly Gly Glu Thr Arg Leu 
        515                 520                 


<210>  17
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TRFC forward primer

<400>  17
atgacgttga attgaacctg gacta                                             25


<210>  18
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TRFC reverse primer

<400>  18
gtctccacga gcggaataca g                                                 21


<210>  19
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TRC probe


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Fluorochrome

<220>
<221>  misc_feature
<222>  (32)..(32)
<223>  Quencher

<400>  19
natcagggat atgggtctaa gtctacagtg gn                                     32


<210>  20
<211>  11928
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Rabies virus vector SAD B19 genome

<400>  20
acgcttaaca accagatcaa agaaaaaaca gacattgtca attgcaaagc aaaaatgtaa       60

cacccctaca atggatgccg acaagattgt attcaaagtc aataatcagg tggtctcttt      120

gaagcctgag attatcgtgg atcaatatga gtacaagtac cctgccatca aagatttgaa      180

aaagccctgt ataaccctag gaaaggctcc cgatttaaat aaagcataca agtcagtttt      240

gtcaggcatg agcgccgcca aacttaatcc tgacgatgta tgttcctatt tggcagcggc      300

aatgcagttt tttgagggga catgtccgga agactggacc agctatggaa ttgtgattgc      360

acgaaaagga gataagatca ccccaggttc tctggtggag ataaaacgta ctgatgtaga      420

agggaattgg gctctgacag gaggcatgga actgacaaga gaccccactg tccctgagca      480

tgcgtcctta gtcggtcttc tcttgagtct gtataggttg agcaaaatat ccgggcaaaa      540

cactggtaac tataagacaa acattgcaga caggatagag cagatttttg agacagcccc      600

ttttgttaaa atcgtggaac accatactct aatgacaact cacaaaatgt gtgctaattg      660

gagtactata ccaaacttca gatttttggc cggaacctat gacatgtttt tctcccggat      720

tgagcatcta tattcagcaa tcagagtggg cacagttgtc actgcttatg aagactgttc      780

aggactggta tcatttactg ggttcataaa acaaatcaat ctcaccgcta gagaggcaat      840

actatatttc ttccacaaga actttgagga agagataaga agaatgtttg agccagggca      900

ggagacagct gttcctcact cttatttcat ccacttccgt tcactaggct tgagtgggaa      960

atctccttat tcatcaaatg ctgttggtca cgtgttcaat ctcattcact ttgtaggatg     1020

ctatatgggt caagtcagat ccctaaatgc aacggttatt gctgcatgtg ctcctcatga     1080

aatgtctgtt ctagggggct atctgggaga ggaattcttc gggaaaggga catttgaaag     1140

aagattcttc agagatgaga aagaacttca agaatacgag gcggctgaac tgacaaagac     1200

tgacgtagca ctggcagatg atggaactgt caactctgac gacgaggact acttttcagg     1260

tgaaaccaga agtccggagg ctgtttatac tcgaatcatg atgaatggag gtcgactaaa     1320

gagatctcac atacggagat atgtctcagt cagttccaat catcaagccc gtccaaactc     1380

attcgccgag tttctaaaca agacatattc gagtgactca taagaagttg aataacaaaa     1440

tgccggaaat ctacggattg tgtatatcca tcatgaaaaa aactaacacc cctcctttcg     1500

aaccatccca aacatgagca agatctttgt caatcctagt gctattagag ccggtctggc     1560

cgatcttgag atggctgaag aaactgttga tctgatcaat agaaatatcg aagacaatca     1620

ggctcatctc caaggggaac ccatagaggt ggacaatctc cctgaggata tggggcgact     1680

tcacctggat gatggaaaat cgcccaacca tggtgagata gccaaggtgg gagaaggcaa     1740

gtatcgagag gactttcaga tggatgaagg agaggatcct agcttcctgt tccagtcata     1800

cctggaaaat gttggagtcc aaatagtcag acaaatgagg tcaggagaga gatttctcaa     1860

gatatggtca cagaccgtag aagagattat atcctatgtc gcggtcaact ttcccaaccc     1920

tccaggaaag tcttcagagg ataaatcaac ccagactact ggccgagagc tcaagaagga     1980

gacaacaccc actccttctc agagagaaag ccaatcatcg aaagccagga tggcggctca     2040

aattgcttct ggccctccag cccttgaatg gtcggctacc aatgaagagg atgatctatc     2100

agtggaggct gagatcgctc accagattgc agaaagtttc tccaaaaaat ataagtttcc     2160

ctctcgatcc tcagggatac tcttgtataa ttttgagcaa ttgaaaatga accttgatga     2220

tatagttaaa gaggcaaaaa atgtaccagg tgtgacccgt ttagcccatg acgggtccaa     2280

actcccccta agatgtgtac tgggatgggt cgctttggcc aactctaaga aattccagtt     2340

gttagtcgaa tccgacaagc tgagtaaaat catgcaagat gacttgaatc gctatacatc     2400

ttgctaaccg aacctctccc ctcagtccct ctagacaata aaatccgaga tgtcccaaag     2460

tcaacatgaa aaaaacaggc aacaccactg ataaaatgaa cctcctacgt aagatagtga     2520

aaaaccgcag ggacgaggac actcaaaaat cctctcccgc gtcagcccct ctggatgacg     2580

atgacttgtg gcttccaccc cctgaatacg tcccgctgaa agaacttaca ggcaagaaga     2640

acatgaggaa cttttgtatc aacggaaggg ttaaagtgtg tagcccgaat ggttactcgt     2700

tcaggatcct gcggcacatt ctgaaatcat tcgacgagat atattctggg aatcatagga     2760

tgatcgggtt agtcaaagtg gttattggac tggctttgtc aggatctcca gtccctgagg     2820

gcctgaactg ggtatacaaa ttgaggagaa cctttatctt ccagtgggct gattccaggg     2880

gccctcttga aggggaggag ttggaatact ctcaggagat cacttgggat gatgatactg     2940

agttcgtcgg attgcaaata agagtgattg caaaacagtg tcatatccag ggcagagtct     3000

ggtgtatcaa catgaacccg agagcatgtc aactatggtc tgacatgtct cttcagacac     3060

aaaggtccga agaggacaaa gattcctctc tgcttctaga ataatcagat tatatcccgc     3120

aaatttatca cttgtttacc tctggaggag agaacatatg ggctcaactc caacccttgg     3180

gagcaatata acaaaaaaca tgttatggtg ccattaaacc gctgcatttc atcaaagtca     3240

agttgattac ctttacattt tgatcctctt ggatgtgaaa aaaactatta acatccctca     3300

aaagactcaa ggaaagatgg ttcctcaggc tctcctgttt gtaccccttc tggtttttcc     3360

attgtgtttt gggaaattcc ctatttacac gataccagac aagcttggtc cctggagtcc     3420

gattgacata catcacctca gctgcccaaa caatttggta gtggaggacg aaggatgcac     3480

caacctgtca gggttctcct acatggaact taaagttgga tacatcttag ccataaaagt     3540

gaacgggttc acttgcacag gcgttgtgac ggaggctgaa acctacacta acttcgttgg     3600

ttatgtcaca accacgttca aaagaaagca tttccgccca acaccagatg catgtagagc     3660

cgcgtacaac tggaagatgg ccggtgaccc cagatatgaa gagtctctac acaatccgta     3720

ccctgactac cgctggcttc gaactgtaaa aaccaccaag gagtctctcg ttatcatatc     3780

tccaagtgtg gcagatttgg acccatatga cagatccctt cactcgaggg tcttccctag     3840

cgggaagtgc tcaggagtag cggtgtcttc tacctactgc tccactaacc acgattacac     3900

catttggatg cccgagaatc cgagactagg gatgtcttgt gacattttta ccaatagtag     3960

agggaagaga gcatccaaag ggagtgagac ttgcggcttt gtagatgaaa gaggcctata     4020

taagtcttta aaaggagcat gcaaactcaa gttatgtgga gttctaggac ttagacttat     4080

ggatggaaca tgggtctcga tgcaaacatc aaatgaaacc aaatggtgcc ctcccgataa     4140

gttggtgaac ctgcacgact ttcgctcaga cgaaattgag caccttgttg tagaggagtt     4200

ggtcaggaag agagaggagt gtctggatgc actagagtcc atcatgacaa ccaagtcagt     4260

gagtttcaga cgtctcagtc atttaagaaa acttgtccct gggtttggaa aagcatatac     4320

catattcaac aagaccttga tggaagccga tgctcactac aagtcagtca gaacttggaa     4380

tgagatcctc ccttcaaaag ggtgtttaag agttgggggg aggtgtcatc ctcatgtgaa     4440

cggggtgttt ttcaatggta taatattagg acctgacggc aatgtcttaa tcccagagat     4500

gcaatcatcc ctcctccagc aacatatgga gttgttggaa tcctcggtta tcccccttgt     4560

gcaccccctg gcagacccgt ctaccgtttt caaggacggt gacgaggctg aggattttgt     4620

tgaagttcac cttcccgatg tgcacaatca ggtctcagga gttgacttgg gtctcccgaa     4680

ctgggggaag tatgtattac tgagtgcagg ggccctgact gccttgatgt tgataatttt     4740

cctgatgaca tgttgtagaa gagtcaatcg atcagaacct acgcaacaca atctcagagg     4800

gacagggagg gaggtgtcag tcactcccca aagcgggaag atcatatctt catgggaatc     4860

acacaagagt gggggtgaga ccagactgta aggactggcc gtcctttcaa cgatccaagt     4920

cctgaagatc acctcccctt ggggggttct ttttgaaaaa cctgggttca atagtcctcc     4980

ttgaactcca tgcaactggg tagattcaag agtcatgaga ttttcattaa tcctctcagt     5040

tgatcaagca agatcatgtc gattctcata ataggggaga tcttctagca gtttcagtga     5100

ctaacggtac tttcattctc caggaactga caccaacagt tgtagacaaa ccacggggtg     5160

tctcgggtga ctctgtgctt gggcacagac aaaggtcatg gtgtgttcca tgatagcgga     5220

ctcaggatga gttaattgag agaggcagtc ttcctcccgt gaaggacata agcagtagct     5280

cacaatcatc tcgcgtctca gcaaagtgtg cataattata aagtgctggg tcatctaagc     5340

ttttcagtcg agaaaaaaac attagatcag aagaacaact ggcaacactt ctcaacctga     5400

gacttacttc aagatgctcg atcctggaga ggtctatgat gaccctattg acccaatcga     5460

gttagaggct gaacccagag gaacccccat tgtccccaac atcttgagga actctgacta     5520

caatctcaac tctcctttga tagaagatcc tgctagacta atgttagaat ggttaaaaac     5580

agggaataga ccttatcgga tgactctaac agacaattgc tccaggtctt tcagagtttt     5640

gaaagattat ttcaagaagg tagatttggg ttctctcaag gtgggcggaa tggctgcaca     5700

gtcaatgatt tctctctggt tatatggtgc ccactctgaa tccaacagga gccggagatg     5760

tataacagac ttggcccatt tctattccaa gtcgtccccc atagagaagc tgttgaatct     5820

cacgctagga aatagagggc tgagaatccc cccagaggga gtgttaagtt gccttgagag     5880

ggttgattat gataatgcat ttggaaggta tcttgccaac acgtattcct cttacttgtt     5940

cttccatgta atcaccttat acatgaacgc cctagactgg gatgaagaaa agaccatcct     6000

agcattatgg aaagatttaa cctcagtgga catcgggaag gacttggtaa agttcaaaga     6060

ccaaatatgg ggactgctga tcgtgacaaa ggactttgtt tactcccaaa gttccaattg     6120

tctttttgac agaaactaca cacttatgct aaaagatctt ttcttgtctc gcttcaactc     6180

cttaatggtc ttgctctctc ccccagagcc ccgatactca gatgacttga tatctcaact     6240

atgccagctg tacattgctg gggatcaagt cttgtctatg tgtggaaact ccggctatga     6300

agtcatcaaa atattggagc catatgtcgt gaatagttta gtccagagag cagaaaagtt     6360

taggcctctc attcattcct tgggagactt tcctgtattt ataaaagaca aggtaagtca     6420

acttgaagag acgttcggtc cctgtgcaag aaggttcttt agggctctgg atcaattcga     6480

caacatacat gacttggttt ttgtgtttgg ctgttacagg cattgggggc acccatatat     6540

agattatcga aagggtctgt caaaactata tgatcaggtt caccttaaaa aaatgataga     6600

taagtcctac caggagtgct tagcaagcga cctagccagg aggatcctta gatggggttt     6660

tgataagtac tccaagtggt atctggattc aagattccta gcccgagacc accccttgac     6720

tccttatatc aaaacccaaa catggccacc caaacatatt gtagacttgg tgggggatac     6780

atggcacaag ctcccgatca cgcagatctt tgagattcct gaatcaatgg atccgtcaga     6840

aatattggat gacaaatcac attctttcac cagaacgaga ctagcttctt ggctgtcaga     6900

aaaccgaggg gggcctgttc ctagcgaaaa agttattatc acggccctgt ctaagccgcc     6960

tgtcaatccc cgagagtttc tgaggtctat agacctcgga ggattgccag atgaagactt     7020

gataattggc ctcaagccaa aggaacggga attgaagatt gaaggtcgat tctttgctct     7080

aatgtcatgg aatctaagat tgtattttgt catcactgaa aaactcttgg ccaactacat     7140

cttgccactt tttgacgcgc tgactatgac agacaacctg aacaaggtgt ttaaaaagct     7200

gatcgacagg gtcaccgggc aagggctttt ggactattca agggtcacat atgcatttca     7260

cctggactat gaaaagtgga acaaccatca aagattagag tcaacagagg atgtattttc     7320

tgtcctagat caagtgtttg gattgaagag agtgttttct agaacacacg agttttttca     7380

aaaggcctgg atctattatt cagacagatc agacctcatc gggttacggg aggatcaaat     7440

atactgctta gatgcgtcca acggcccaac ctgttggaat ggccaggatg gcgggctaga     7500

aggcttacgg cagaagggct ggagtctagt cagcttattg atgatagata gagaatctca     7560

aatcaggaac acaagaacca aaatactagc tcaaggagac aaccaggttt tatgtccgac     7620

atacatgttg tcgccagggc tatctcaaga ggggctcctc tatgaattgg agagaatatc     7680

aaggaatgca ctttcgatat acagagccgt cgaggaaggg gcatctaagc tagggctgat     7740

catcaagaaa gaagagacca tgtgtagtta tgacttcctc atctatggaa aaaccccttt     7800

gtttagaggt aacatattgg tgcctgagtc caaaagatgg gccagagtct cttgcgtctc     7860

taatgaccaa atagtcaacc tcgccaatat aatgtcgaca gtgtccacca atgcgctaac     7920

agtggcacaa cactctcaat ctttgatcaa accgatgagg gattttctgc tcatgtcagt     7980

acaggcagtc tttcactacc tgctatttag cccaatctta aagggaagag tttacaagat     8040

tctgagcgct gaaggggaga gctttctcct agccatgtca aggataatct atctagatcc     8100

ttctttggga gggatatctg gaatgtccct cggaagattc catatacgac agttctcaga     8160

ccctgtctct gaagggttat ccttctggag agagatctgg ttaagctccc aagagtcctg     8220

gattcacgcg ttgtgtcaag aggctggaaa cccagatctt ggagagagaa cactcgagag     8280

cttcactcgc cttctagaag atccgaccac cttaaatatc agaggagggg ccagtcctac     8340

cattctactc aaggatgcaa tcagaaaggc tttatatgac gaggtggaca aggtggaaaa     8400

ttcagagttt cgagaggcaa tcctgttgtc caagacccat agagataatt ttatactctt     8460

cttaatatct gttgagcctc tgtttcctcg atttctcagt gagctattca gttcgtcttt     8520

tttgggaatc cccgagtcaa tcattggatt gatacaaaac tcccgaacga taagaaggca     8580

gtttagaaag agtctctcaa aaactttaga agaatccttc tacaactcag agatccacgg     8640

gattagtcgg atgacccaga cacctcagag ggttgggggg gtgtggcctt gctcttcaga     8700

gagggcagat ctacttaggg agatctcttg gggaagaaaa gtggtaggca cgacagttcc     8760

tcacccttct gagatgttgg gattacttcc caagtcctct atttcttgca cttgtggagc     8820

aacaggagga ggcaatccta gagtttctgt atcagtactc ccgtcctttg atcagtcatt     8880

tttttcacga ggccccctaa agggatactt gggctcgtcc acctctatgt cgacccagct     8940

attccatgca tgggaaaaag tcactaatgt tcatgtggtg aagagagctc tatcgttaaa     9000

agaatctata aactggttca ttactagaga ttccaacttg gctcaagctc taattaggaa     9060

cattatgtct ctgacaggcc ctgatttccc tctagaggag gcccctgtct tcaaaaggac     9120

ggggtcagcc ttgcataggt tcaagtctgc cagatacagc gaaggagggt attcttctgt     9180

ctgcccgaac ctcctctctc atatttctgt tagtacagac accatgtctg atttgaccca     9240

agacgggaag aactacgatt tcatgttcca gccattgatg ctttatgcac agacatggac     9300

atcagagctg gtacagagag acacaaggct aagagactct acgtttcatt ggcacctccg     9360

atgcaacagg tgtgtgagac ccattgacga cgtgaccctg gagacctctc agatcttcga     9420

gtttccggat gtgtcgaaaa gaatatccag aatggtttct ggggctgtgc ctcacttcca     9480

gaggcttccc gatatccgtc tgagaccagg agattttgaa tctctaagcg gtagagaaaa     9540

gtctcaccat atcggatcag ctcaggggct cttatactca atcttagtgg caattcacga     9600

ctcaggatac aatgatggaa ccatcttccc tgtcaacata tacggcaagg tttcccctag     9660

agactatttg agagggctcg caaggggagt attgatagga tcctcgattt gcttcttgac     9720

aagaatgaca aatatcaata ttaatagacc tcttgaattg gtctcagggg taatctcata     9780

tattctcctg aggctagata accatccctc cttgtacata atgctcagag aaccgtctct     9840

tagaggagag atattttcta tccctcagaa aatccccgcc gcttatccaa ccactatgaa     9900

agaaggcaac agatcaatct tgtgttatct ccaacatgtg ctacgctatg agcgagagat     9960

aatcacggcg tctccagaga atgactggct atggatcttt tcagacttta gaagtgccaa    10020

aatgacgtac ctatccctca ttacttacca gtctcatctt ctactccaga gggttgagag    10080

aaacctatct aagagtatga gagataacct gcgacaattg agttctttga tgaggcaggt    10140

gctgggcggg cacggagaag ataccttaga gtcagacgac aacattcaac gactgctaaa    10200

agactcttta cgaaggacaa gatgggtgga tcaagaggtg cgccatgcag ctagaaccat    10260

gactggagat tacagcccca acaagaaggt gtcccgtaag gtaggatgtt cagaatgggt    10320

ctgctctgct caacaggttg cagtctctac ctcagcaaac ccggcccctg tctcggagct    10380

tgacataagg gccctctcta agaggttcca gaaccctttg atctcgggct tgagagtggt    10440

tcagtgggca accggtgctc attataagct taagcctatt ctagatgatc tcaatgtttt    10500

cccatctctc tgccttgtag ttggggacgg gtcagggggg atatcaaggg cagtcctcaa    10560

catgtttcca gatgccaagc ttgtgttcaa cagtctttta gaggtgaatg acctgatggc    10620

ttccggaaca catccactgc ctccttcagc aatcatgagg ggaggaaatg atatcgtctc    10680

cagagtgata gatcttgact caatctggga aaaaccgtcc gacttgagaa acttggcaac    10740

ctggaaatac ttccagtcag tccaaaagca ggtcaacatg tcctatgacc tcattatttg    10800

cgatgcagaa gttactgaca ttgcatctat caaccggatc accctgttaa tgtccgattt    10860

tgcattgtct atagatggac cactctattt ggtcttcaaa acttatggga ctatgctagt    10920

aaatccaaac tacaaggcta ttcaacacct gtcaagagcg ttcccctcgg tcacagggtt    10980

tatcacccaa gtaacttcgt ctttttcatc tgagctctac ctccgattct ccaaacgagg    11040

gaagtttttc agagatgctg agtacttgac ctcttccacc cttcgagaaa tgagccttgt    11100

gttattcaat tgtagcagcc ccaagagtga gatgcagaga gctcgttcct tgaactatca    11160

ggatcttgtg agaggatttc ctgaagaaat catatcaaat ccttacaatg agatgatcat    11220

aactctgatt gacagtgatg tagaatcttt tctagtccac aagatggttg atgatcttga    11280

gttacagagg ggaactctgt ctaaagtggc tatcattata gccatcatga tagttttctc    11340

caacagagtc ttcaacgttt ccaaacccct aactgacccc tcgttctatc caccgtctga    11400

tcccaaaatc ctgaggcact tcaacatatg ttgcagtact atgatgtatc tatctactgc    11460

tttaggtgac gtccctagct tcgcaagact tcacgacctg tataacagac ctataactta    11520

ttacttcaga aagcaagtca ttcgagggaa cgtttatcta tcttggagtt ggtccaacga    11580

cacctcagtg ttcaaaaggg tagcctgtaa ttctagcctg agtctgtcat ctcactggat    11640

caggttgatt tacaagatag tgaagactac cagactcgtt ggcagcatca aggatctatc    11700

cagagaagtg gaaagacacc ttcataggta caacaggtgg atcaccctag aggatatcag    11760

atctagatca tccctactag actacagttg cctgtgaacc ggatactcct ggaagcctgc    11820

ccatgctaag actcttgtgt gatgtatctt gaaaaaaaca agatcctaaa tctgaacctt    11880

tggttgtttg attgtttttc tcatttttgt tgtttatttg ttaagcgt                 11928


<210>  21
<211>  14108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Recombinant Rabies virus vector BNSP333 expressing a chimeric 
       protein comprising the S1 domain of Middle East Respiratory 
       Syndrome Coronavirus fused to the C-terminal part of the Rabies 
       virus G glycoprotein (amino acids 428-524)

<400>  21
acgcttaaca accagatcaa agaaaaaaca gacattgtca attgcaaagc aaaaatgtaa       60

cacccctaca atggatgccg acaagattgt attcaaagtc aataatcagg tggtctcttt      120

gaagcctgag attatcgtgg atcaatatga gtacaagtac cctgccatca aagatttgaa      180

aaagccctgt ataaccctag gaaaggctcc cgatttaaat aaagcataca agtcagtttt      240

gtcaggcatg agcgccgcca aacttaatcc tgacgatgta tgttcctatt tggcagcggc      300

aatgcagttt tttgagggga catgtccgga agactggacc agctatggaa ttgtgattgc      360

acgaaaagga gataagatca ccccaggttc tctggtggag ataaaacgta ctgatgtaga      420

agggaattgg gctctgacag gaggcatgga actgacaaga gaccccactg tccctgagca      480

tgcgtcctta gtcggtcttc tcttgagtct gtataggttg agcaaaatat ccgggcaaaa      540

cactggtaac tataagacaa acattgcaga caggatagag cagatttttg agacagcccc      600

ttttgttaaa atcgtggaac accatactct aatgacaact cacaaaatgt gtgctaattg      660

gagtactata ccaaacttca gatttttggc cggaacctat gacatgtttt tctcccggat      720

tgagcatcta tattcagcaa tcagagtggg cacagttgtc actgcttatg aagactgttc      780

aggactggta tcatttactg ggttcataaa acaaatcaat ctcaccgcta gagaggcaat      840

actatatttc ttccacaaga actttgagga agagataaga agaatgtttg agccagggca      900

ggagacagct gttcctcact cttatttcat ccacttccgt tcactaggct tgagtgggaa      960

atctccttat tcatcaaatg ctgttggtca cgtgttcaat ctcattcact ttgtaggatg     1020

ctatatgggt caagtcagat ccctaaatgc aacggttatt gctgcatgtg ctcctcatga     1080

aatgtctgtt ctagggggct atctgggaga ggaattcttc gggaaaggga catttgaaag     1140

aagattcttc agagatgaga aagaacttca agaatacgag gcggctgaac tgacaaagac     1200

tgacgtagca ctggcagatg atggaactgt caactctgac gacgaggact acttttcagg     1260

tgaaaccaga agtccggagg ctgtttatac tcgaatcatg atgaatggag gtcgactaaa     1320

gagatctcac atacggagat atgtctcagt cagttccaat catcaagccc gtccaaactc     1380

attcgccgag tttctaaaca agacatattc gagtgactca taacatgaaa aaaactaaca     1440

cccctcccgt acgccgccac catgattcac tctgtgttcc tgctgatgtt cctgctgaca     1500

ccaacagagt cctatgtgga tgtgggacct gactctgtga agtctgcctg tattgaggtg     1560

gacatccaac agaccttctt tgacaagacc tggccaagac caattgatgt gagcaaggct     1620

gatggcatca tctacccaca gggcaggacc tacagcaaca tcaccatcac ctaccaggga     1680

ctgtttccat accagggaga tcatggagat atgtatgtct actctgctgg tcatgccaca     1740

ggcaccacac cacagaaact gtttgtggct aactacagcc aggatgtgaa gcagtttgcc     1800

aatggctttg tggtgaggat tggagcagca gccaacagca caggcacagt gattatcagc     1860

ccaagcacct ctgccaccat caggaagatt taccctgcct ttatgctggg ctcctctgtg     1920

ggcaacttct ctgatggcaa gatgggcagg ttcttcaacc acaccctggt gctgctgcct     1980

gatggctgtg gcaccctgct gagggctttc tactgtatct tggaaccaag gtctggcaac     2040

cactgtcctg ctggcaactc ctacacctcc tttgccacct accacacacc tgccacagac     2100

tgttctgatg gcaactacaa caggaatgcc tccctgaact ccttcaagga atacttcaac     2160

ctgaggaact gtacctttat gtacacctac aacatcacag aggatgagat tttggagtgg     2220

tttggcatca cccagacagc ccagggagtg catctgttct cgagcagata tgtggacctc     2280

tatggaggca atatgttcca gtttgccacc ctgcctgtct atgacaccat caaatactac     2340

agcatcatcc cacacagcat caggagcatc cagtctgaca ggaaggcttg ggctgccttc     2400

tatgtctaca aactccaacc actgaccttc ctgctggact tctctgtgga tggctacatc     2460

aggagggcta ttgactgtgg cttcaatgac ctgagccaac ttcactgttc ctatgagtcc     2520

tttgatgtgg agtctggagt ctactctgtg tcctcctttg aggctaagcc atctggctct     2580

gtggtggaac aggctgaggg agtggagtgt gacttcagcc cactgctgtc tggcacacct     2640

ccacaggtct acaacttcaa gagactggtg ttcaccaact gtaactacaa cctgaccaaa     2700

ctgctgtccc tgttctctgt gaatgacttc acttgtagcc agattagccc tgctgccatt     2760

gccagcaact gttactcctc cctgattctg gactacttct cctacccact gagtatgaag     2820

tctgacctgt ctgtgtcctc tgctggacca atcagccagt tcaactacaa gcagtccttc     2880

agcaacccaa cttgtctgat tctggctaca gtgccacaca acctgaccac catcaccaag     2940

ccactgaaat actcctacat caacaagtgt agcagactgc tgtctgatga caggacagag     3000

gtgccacaac tagtgaatgc caaccaatac agcccatgtg tgagcattgt gccaagcaca     3060

gtgtgggagg atggagacta ctacaggaag caacttagcc cattggaggg aggaggctgg     3120

ctggtggcat ctggcagcac agtggctatg acagaacaac tccaaatggg ctttggcatc     3180

acagtccaat atggcacaga caccaactct gtgtgtccaa aattggagtt tgccaatgac     3240

accaagattg ccagccaact tggcaactgt gtggaatact ccctctatgg agtgtctggc     3300

aggggagtgt tccagaactg tactgctgtg ggagtgagac aacagaggtt tgtctatgat     3360

gcctaccaga acctggtggg ctactactct gatgatggca actactactg tctgagggct     3420

tgtgtgtctg tgcctgtgtc tgtgatttat gacaaggaga ccaagaccca tgccaccctg     3480

tttggctctg tggcttgtga acacatctcc agcacaatga gtcaatacag caggagcacc     3540

aggagtatgc tgaaaaggag ggacagcaca tatggaccac tccaaacacc tgtgggctgt     3600

gtgctgggac tggtgaactc ctccctgttt gtggaggact gtaaactgcc actgggacaa     3660

tccctgtgtg ccctgcctga cacaccaagc accctgacac caaggtctgt gggagatgag     3720

gccgaagact ttgtggaagt ccacctgcct gatgtgcata accaggtgtc tggcgtcgac     3780

ctgggactgc caaattgggg caagtacgtg ctgctgagtg ctggagcact gactgccctg     3840

atgctgatca ttttcctgat gacctgctgt cggcgcgtga acagaagtga gcccactcag     3900

cacaatctgc gaggaaccgg gagagaagtg tcagtcacac ctcagagcgg gaaaatcatt     3960

agtagttggg aatcacataa aagcgggggc gagaccaggc tgtgagctag ccatgaaaaa     4020

aactaacacc cctcctttcg aaccatccca aacatgagca agatctttgt caatcctagt     4080

gctattagag ccggtctggc cgatcttgag atggctgaag aaactgttga tctgatcaat     4140

agaaatatcg aagacaatca ggctcatctc caaggggaac ccatagaggt ggacaatctc     4200

cctgaggata tggggcgact tcacctggat gatggaaaat cgcccaacca tggtgagata     4260

gccaaggtgg gagaaggcaa gtatcgagag gactttcaga tggatgaagg agaggatcct     4320

agcttcctgt tccagtcata cctggaaaat gttggagtcc aaatagtcag acaaatgagg     4380

tcaggagaga gatttctcaa gatatggtca cagaccgtag aagagattat atcctatgtc     4440

gcggtcaact ttcccaaccc tccaggaaag tcttcagagg ataaatcaac ccagactact     4500

ggccgagagc tcaagaagga gacaacaccc actccttctc agagagaaag ccaatcatcg     4560

aaagccagga tggcggctca aattgcttct ggccctccag cccttgaatg gtcggctacc     4620

aatgaagagg atgatctatc agtggaggct gagatcgctc accagattgc agaaagtttc     4680

tccaaaaaat ataagtttcc ctctcgatcc tcagggatac tcttgtataa ttttgagcaa     4740

ttgaaaatga accttgatga tatagttaaa gaggcaaaaa atgtaccagg tgtgacccgt     4800

ttagcccatg acgggtccaa actcccccta agatgtgtac tgggatgggt cgctttggcc     4860

aactctaaga aattccagtt gttagtcgaa tccgacaagc tgagtaaaat catgcaagat     4920

gacttgaatc gctatacatc ttgctaaccg aacctctccc ctcagtccct ctagacaata     4980

aaatccgaga tgtcccaaag tcaacatgaa aaaaacaggc aacaccactg ataaaatgaa     5040

cctcctacgt aagatagtga aaaaccgcag ggacgaggac actcaaaaat cctctcccgc     5100

gtcagcccct ctggatgacg atgacttgtg gcttccaccc cctgaatacg tcccgctgaa     5160

agaacttaca ggcaagaaga acatgaggaa cttttgtatc aacggaaggg ttaaagtgtg     5220

tagcccgaat ggttactcgt tcaggatcct gcggcacatt ctgaaatcat tcgacgagat     5280

atattctggg aatcatagga tgatcgggtt agtcaaagtg gttattggac tggctttgtc     5340

aggatctcca gtccctgagg gcctgaactg ggtatacaaa ttgaggagaa cctttatctt     5400

ccagtgggct gattccaggg gccctcttga aggggaggag ttggaatact ctcaggagat     5460

cacttgggat gatgatactg agttcgtcgg attgcaaata agagtgattg caaaacagtg     5520

tcatatccag ggcagagtct ggtgtatcaa catgaacccg agagcatgtc aactatggtc     5580

tgacatgtct cttcagacac aaaggtccga agaggacaaa gattcctctc tgcttctaga     5640

ataatcagat tatatcccgc aaatttatca cttgtttacc tctggaggag agaacatatg     5700

ggctcaactc caacccttgg gagcaatata acaaaaaaca tgttatggtg ccattaaacc     5760

gctgcatttc atcaaagtca agttgattac ctttacattt tgatcctctt ggatgtgaaa     5820

aaaactatta acatccctca aaagaccccg ggaaagatgg ttcctcaggc tctcctgttt     5880

gtaccccttc tggtttttcc attgtgtttt gggaaattcc ctatttacac gataccagac     5940

aagcttggtc cctggagtcc gattgacata catcacctca gctgcccaaa caatttggta     6000

gtggaggacg aaggatgcac caacctgtca gggttctcct acatggaact taaagttgga     6060

tacatcttag ccataaaagt gaacgggttc acttgcacag gcgttgtgac ggaggctgaa     6120

acctacacta acttcgttgg ttatgtcaca accacgttca aaagaaagca tttccgccca     6180

acaccagatg catgtagagc cgcgtacaac tggaagatgg ccggtgaccc cagatatgaa     6240

gagtctctac acaatccgta ccctgactac cgctggcttc gaactgtaaa aaccaccaag     6300

gagtctctcg ttatcatatc tccaagtgtg gcagatttgg acccatatga cagatccctt     6360

cactcgaggg tcttccctag cgggaagtgc tcaggagtag cggtgtcttc tacctactgc     6420

tccactaacc acgattacac catttggatg cccgagaatc cgagactagg gatgtcttgt     6480

gacattttta ccaatagtag agggaagaga gcatccaaag ggagtgagac ttgcggcttt     6540

gtagatgaaa gaggcctata taagtcttta aaaggagcat gcaaactcaa gttatgtgga     6600

gttctaggac ttagacttat ggatggaaca tgggtctcga tgcaaacatc aaatgaaacc     6660

aaatggtgcc ctcccgataa gttggtgaac ctgcacgact ttcgctcaga cgaaattgag     6720

caccttgttg tagaggagtt ggtcaggaag agagaggagt gtctggatgc actagagtcc     6780

atcatgacaa ccaagtcagt gagtttcaga cgtctcagtc atttaagaaa acttgtccct     6840

gggtttggaa aagcatatac catattcaac aagaccttga tggaagccga tgctcactac     6900

aagtcagtcg agacttggaa tgagatcctc ccttcaaaag ggtgtttaag agttgggggg     6960

aggtgtcatc ctcatgtgaa cggggtgttt ttcaatggta taatattagg acctgacggc     7020

aatgtcttaa tcccagagat gcaatcatcc ctcctccagc aacatatgga gttgttggaa     7080

tcctcggtta tcccccttgt gcaccccctg gcagacccgt ctaccgtttt caaggacggt     7140

gacgaggctg aggattttgt tgaagttcac cttcccgatg tgcacaatca ggtctcagga     7200

gttgacttgg gtctcccgaa ctgggggaag tatgtattac tgagtgcagg ggccctgact     7260

gccttgatgt tgataatttt cctgatgaca tgttgtagaa gagtcaatcg atcagaacct     7320

acgcaacaca atctcagagg gacagggagg gaggtgtcag tcactcccca aagcgggaag     7380

atcatatctt catgggaatc acacaagagt gggggtgaga ccagactgta attaattaac     7440

gtcctttcaa cgatccaagt ccatgaaaaa aactaacacc cctcccgtac ctagcttata     7500

aagtgctggg tcatctaagc ttttcagtcg agaaaaaaac attagatcag aagaacaact     7560

ggcaacactt ctcaacctga gacttacttc aagatgctcg atcctggaga ggtctatgat     7620

gaccctattg acccaatcga gttagaggct gaacccagag gaacccccat tgtccccaac     7680

atcttgagga actctgacta caatctcaac tctcctttga tagaagatcc tgctagacta     7740

atgttagaat ggttaaaaac agggaataga ccttatcgga tgactctaac agacaattgc     7800

tccaggtctt tcagagtttt gaaagattat ttcaagaagg tagatttggg ttctctcaag     7860

gtgggcggaa tggctgcaca gtcaatgatt tctctctggt tatatggtgc ccactctgaa     7920

tccaacagga gccggagatg tataacagac ttggcccatt tctattccaa gtcgtccccc     7980

atagagaagc tgttgaatct cacgctagga aatagagggc tgagaatccc cccagaggga     8040

gtgttaagtt gccttgagag ggttgattat gataatgcat ttggaaggta tcttgccaac     8100

acgtattcct cttacttgtt cttccatgta atcaccttat acatgaacgc cctagactgg     8160

gatgaagaaa agaccatcct agcattatgg aaagatttaa cctcagtgga catcgggaag     8220

gacttggtaa agttcaaaga ccaaatatgg ggactgctga tcgtgacaaa ggactttgtt     8280

tactcccaaa gttccaattg tctttttgac agaaactaca cacttatgct aaaagatctt     8340

ttcttgtctc gcttcaactc cttaatggtc ttgctctctc ccccagagcc ccgatactca     8400

gatgacttga tatctcaact atgccagctg tacattgctg gggatcaagt cttgtctatg     8460

tgtggaaact ccggctatga agtcatcaaa atattggagc catatgtcgt gaatagttta     8520

gtccagagag cagaaaagtt taggcctctc attcattcct tgggagactt tcctgtattt     8580

ataaaagaca aggtaagtca acttgaagag acgttcggtc cctgtgcaag aaggttcttt     8640

agggctctgg atcaattcga caacatacat gacttggttt ttgtgtttgg ctgttacagg     8700

cattgggggc acccatatat agattatcga aagggtctgt caaaactata tgatcaggtt     8760

caccttaaaa aaatgataga taagtcctac caggagtgct tagcaagcga cctagccagg     8820

aggatcctta gatggggttt tgataagtac tccaagtggt atctggattc aagattccta     8880

gcccgagacc accccttgac tccttatatc aaaacccaaa catggccacc caaacatatt     8940

gtagacttgg tgggggatac atggcacaag ctcccgatca cgcagatctt tgagattcct     9000

gaatcaatgg atccgtcaga aatattggat gacaaatcac attctttcac cagaacgaga     9060

ctagcttctt ggctgtcaga aaaccgaggg gggcctgttc ctagcgaaaa agttattatc     9120

acggccctgt ctaagccgcc tgtcaatccc cgagagtttc tgaggtctat agacctcgga     9180

ggattgccag atgaagactt gataattggc ctcaagccaa aggaacggga attgaagatt     9240

gaaggtcgat tctttgctct aatgtcatgg aatctaagat tgtattttgt catcactgaa     9300

aaactcttgg ccaactacat cttgccactt tttgacgcgc tgactatgac agacaacctg     9360

aacaaggtgt ttaaaaagct gatcgacagg gtcaccgggc aagggctttt ggactattca     9420

agggtcacat atgcatttca cctggactat gaaaagtgga acaaccatca aagattagag     9480

tcaacagagg atgtattttc tgtcctagat caagtgtttg gattgaagag agtgttttct     9540

agaacacacg agttttttca aaaggcctgg atctattatt cagacagatc agacctcatc     9600

gggttacggg aggatcaaat atactgctta gatgcgtcca acggcccaac ctgttggaat     9660

ggccaggatg gcgggctaga aggcttacgg cagaagggct ggagtctagt cagcttattg     9720

atgatagata gagaatctca aatcaggaac acaagaacca aaatactagc tcaaggagac     9780

aaccaggttt tatgtccgac atacatgttg tcgccagggc tatctcaaga ggggctcctc     9840

tatgaattgg agagaatatc aaggaatgca ctttcgatat acagagccgt cgaggaaggg     9900

gcatctaagc tagggctgat catcaagaaa gaagagacca tgtgtagtta tgacttcctc     9960

atctatggaa aaaccccttt gtttagaggt aacatattgg tgcctgagtc caaaagatgg    10020

gccagagtct cttgcgtctc taatgaccaa atagtcaacc tcgccaatat aatgtcgaca    10080

gtgtccacca atgcgctaac agtggcacaa cactctcaat ctttgatcaa accgatgagg    10140

gattttctgc tcatgtcagt acaggcagtc tttcactacc tgctatttag cccaatctta    10200

aagggaagag tttacaagat tctgagcgct gaaggggaga gctttctcct agccatgtca    10260

aggataatct atctagatcc ttctttggga gggatatctg gaatgtccct cggaagattc    10320

catatacgac agttctcaga ccctgtctct gaagggttat ccttctggag agagatctgg    10380

ttaagctccc aagagtcctg gattcacgcg ttgtgtcaag aggctggaaa cccagatctt    10440

ggagagagaa cactcgagag cttcactcgc cttctagaag atccgaccac cttaaatatc    10500

agaggagggg ccagtcctac cattctactc aaggatgcaa tcagaaaggc tttatatgac    10560

gaggtggaca aggtggaaaa ttcagagttt cgagaggcaa tcctgttgtc caagacccat    10620

agagataatt ttatactctt cttaatatct gttgagcctc tgtttcctcg atttctcagt    10680

gagctattca gttcgtcttt tttgggaatc cccgagtcaa tcattggatt gatacaaaac    10740

tcccgaacga taagaaggca gtttagaaag agtctctcaa aaactttaga agaatccttc    10800

tacaactcag agatccacgg gattagtcgg atgacccaga cacctcagag ggttgggggg    10860

gtgtggcctt gctcttcaga gagggcagat ctacttaggg agatctcttg gggaagaaaa    10920

gtggtaggca cgacagttcc tcacccttct gagatgttgg gattacttcc caagtcctct    10980

atttcttgca cttgtggagc aacaggagga ggcaatccta gagtttctgt atcagtactc    11040

ccgtcctttg atcagtcatt tttttcacga ggccccctaa agggatactt gggctcgtcc    11100

acctctatgt cgacccagct attccatgca tgggaaaaag tcactaatgt tcatgtggtg    11160

aagagagctc tatcgttaaa agaatctata aactggttca ttactagaga ttccaacttg    11220

gctcaagctc taattaggaa cattatgtct ctgacaggcc ctgatttccc tctagaggag    11280

gcccctgtct tcaaaaggac ggggtcagcc ttgcataggt tcaagtctgc cagatacagc    11340

gaaggagggt attcttctgt ctgcccgaac ctcctctctc atatttctgt tagtacagac    11400

accatgtctg atttgaccca agacgggaag aactacgatt tcatgttcca gccattgatg    11460

ctttatgcac agacatggac atcagagctg gtacagagag acacaaggct aagagactct    11520

acgtttcatt ggcacctccg atgcaacagg tgtgtgagac ccattgacga cgtgaccctg    11580

gagacctctc agatcttcga gtttccggat gtgtcgaaaa gaatatccag aatggtttct    11640

ggggctgtgc ctcacttcca gaggcttccc gatatccgtc tgagaccagg agattttgaa    11700

tctctaagcg gtagagaaaa gtctcaccat atcggatcag ctcaggggct cttatactca    11760

atcttagtgg caattcacga ctcaggatac aatgatggaa ccatcttccc tgtcaacata    11820

tacggcaagg tttcccctag agactatttg agagggctcg caaggggagt attgatagga    11880

tcctcgattt gcttcttgac aagaatgaca aatatcaata ttaatagacc tcttgaattg    11940

gtctcagggg taatctcata tattctcctg aggctagata accatccctc cttgtacata    12000

atgctcagag aaccgtctct tagaggagag atattttcta tccctcagaa aatccccgcc    12060

gcttatccaa ccactatgaa agaaggcaac agatcaatct tgtgttatct ccaacatgtg    12120

ctacgctatg agcgagagat aatcacggcg tctccagaga atgactggct atggatcttt    12180

tcagacttta gaagtgccaa aatgacgtac ctatccctca ttacttacca gtctcatctt    12240

ctactccaga gggttgagag aaacctatct aagagtatga gagataacct gcgacaattg    12300

agttctttga tgaggcaggt gctgggcggg cacggagaag ataccttaga gtcagacgac    12360

aacattcaac gactgctaaa agactcttta cgaaggacaa gatgggtgga tcaagaggtg    12420

cgccatgcag ctagaaccat gactggagat tacagcccca acaagaaggt gtcccgtaag    12480

gtaggatgtt cagaatgggt ctgctctgct caacaggttg cagtctctac ctcagcaaac    12540

ccggcccctg tctcggagct tgacataagg gccctctcta agaggttcca gaaccctttg    12600

atctcgggct tgagagtggt tcagtgggca accggtgctc attataagct taagcctatt    12660

ctagatgatc tcaatgtttt cccatctctc tgccttgtag ttggggacgg gtcagggggg    12720

atatcaaggg cagtcctcaa catgtttcca gatgccaagc ttgtgttcaa cagtctttta    12780

gaggtgaatg acctgatggc ttccggaaca catccactgc ctccttcagc aatcatgagg    12840

ggaggaaatg atatcgtctc cagagtgata gatcttgact caatctggga aaaaccgtcc    12900

gacttgagaa acttggcaac ctggaaatac ttccagtcag tccaaaagca ggtcaacatg    12960

tcctatgacc tcattatttg cgatgcagaa gttactgaca ttgcatctat caaccggatc    13020

accctgttaa tgtccgattt tgcattgtct atagatggac cactctattt ggtcttcaaa    13080

acttatggga ctatgctagt aaatccaaac tacaaggcta ttcaacacct gtcaagagcg    13140

ttcccctcgg tcacagggtt tatcacccaa gtaacttcgt ctttttcatc tgagctctac    13200

ctccgattct ccaaacgagg gaagtttttc agagatgctg agtacttgac ctcttccacc    13260

cttcgagaaa tgagccttgt gttattcaat tgtagcagcc ccaagagtga gatgcagaga    13320

gctcgttcct tgaactatca ggatcttgtg agaggatttc ctgaagaaat catatcaaat    13380

ccttacaatg agatgatcat aactctgatt gacagtgatg tagaatcttt tctagtccac    13440

aagatggttg atgatcttga gttacagagg ggaactctgt ctaaagtggc tatcattata    13500

gccatcatga tagttttctc caacagagtc ttcaacgttt ccaaacccct aactgacccc    13560

tcgttctatc caccgtctga tcccaaaatc ctgaggcact tcaacatatg ttgcagtact    13620

atgatgtatc tatctactgc tttaggtgac gtccctagct tcgcaagact tcacgacctg    13680

tataacagac ctataactta ttacttcaga aagcaagtca ttcgagggaa cgtttatcta    13740

tcttggagtt ggtccaacga cacctcagtg ttcaaaaggg tagcctgtaa ttctagcctg    13800

agtctgtcat ctcactggat caggttgatt tacaagatag tgaagactac cagactcgtt    13860

ggcagcatca aggatctatc cagagaagtg gaaagacacc ttcataggta caacaggtgg    13920

atcaccctag aggatatcag atctagatca tccctactag actacagttg cctgtgaacc    13980

ggatactcct ggaagcctgc ccatgctaag actcttgtgt gatgtatctt gaaaaaaaca    14040

agatcctaaa tctgaacctt tggttgtttg attgtttttc tcatttttgt tgtttatttg    14100

ttaagcgt                                                             14108


<210>  22
<211>  15629
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Recombinant Rabies virus vector BNSP333 expressing a wild type 
       Middle East Respiratory Syndrome spike glycoprotein.

<400>  22
acgcttaaca accagatcaa agaaaaaaca gacattgtca attgcaaagc aaaaatgtaa       60

cacccctaca atggatgccg acaagattgt attcaaagtc aataatcagg tggtctcttt      120

gaagcctgag attatcgtgg atcaatatga gtacaagtac cctgccatca aagatttgaa      180

aaagccctgt ataaccctag gaaaggctcc cgatttaaat aaagcataca agtcagtttt      240

gtcaggcatg agcgccgcca aacttaatcc tgacgatgta tgttcctatt tggcagcggc      300

aatgcagttt tttgagggga catgtccgga agactggacc agctatggaa ttgtgattgc      360

acgaaaagga gataagatca ccccaggttc tctggtggag ataaaacgta ctgatgtaga      420

agggaattgg gctctgacag gaggcatgga actgacaaga gaccccactg tccctgagca      480

tgcgtcctta gtcggtcttc tcttgagtct gtataggttg agcaaaatat ccgggcaaaa      540

cactggtaac tataagacaa acattgcaga caggatagag cagatttttg agacagcccc      600

ttttgttaaa atcgtggaac accatactct aatgacaact cacaaaatgt gtgctaattg      660

gagtactata ccaaacttca gatttttggc cggaacctat gacatgtttt tctcccggat      720

tgagcatcta tattcagcaa tcagagtggg cacagttgtc actgcttatg aagactgttc      780

aggactggta tcatttactg ggttcataaa acaaatcaat ctcaccgcta gagaggcaat      840

actatatttc ttccacaaga actttgagga agagataaga agaatgtttg agccagggca      900

ggagacagct gttcctcact cttatttcat ccacttccgt tcactaggct tgagtgggaa      960

atctccttat tcatcaaatg ctgttggtca cgtgttcaat ctcattcact ttgtaggatg     1020

ctatatgggt caagtcagat ccctaaatgc aacggttatt gctgcatgtg ctcctcatga     1080

aatgtctgtt ctagggggct atctgggaga ggaattcttc gggaaaggga catttgaaag     1140

aagattcttc agagatgaga aagaacttca agaatacgag gcggctgaac tgacaaagac     1200

tgacgtagca ctggcagatg atggaactgt caactctgac gacgaggact acttttcagg     1260

tgaaaccaga agtccggagg ctgtttatac tcgaatcatg atgaatggag gtcgactaaa     1320

gagatctcac atacggagat atgtctcagt cagttccaat catcaagccc gtccaaactc     1380

attcgccgag tttctaaaca agacatattc gagtgactca taacatgaaa aaaactaaca     1440

cccctcccgt acgccgccac catgatacac tcagtgtttc tactgatgtt cttgttaaca     1500

cctacagaaa gttacgttga tgtagggcca gattctgtta agtctgcttg tattgaggtt     1560

gatatacaac agactttctt tgataaaact tggcctaggc caattgatgt ttctaaggct     1620

gacggtatta tataccctca aggccgtaca tattctaaca taactatcac ttatcaaggt     1680

ctttttccct atcagggaga ccatggtgat atgtatgttt actctgcagg acatgctaca     1740

ggcacaactc cacaaaagtt gtttgtagct aactattctc aggacgtcaa acagtttgct     1800

aatgggtttg tcgtccgtat aggagcagct gccaattcca ctggcactgt tattattagc     1860

ccatctacca gcgctactat acgaaaaatt taccctgctt ttatgctggg ttcttcagtt     1920

ggtaatttct cagatggtaa aatgggccgc ttcttcaatc atactctagt tcttttgccc     1980

gatggatgtg gcactttact tagagctttt tattgtattc tagagcctcg ctctggaaat     2040

cattgtcctg ctggcaattc ctatacttct tttgccactt atcacactcc tgcaacagat     2100

tgttctgatg gcaattacaa tcgtaatgcc agtctgaact cttttaagga gtattttaat     2160

ttacgtaact gcacctttat gtacacttat aacattaccg aagatgagat tttagagtgg     2220

tttggcatta cacaaactgc tcaaggtgtt cacctcttct catctcggta tgttgatttg     2280

tacggcggca atatgtttca atttgccacc ttgcctgttt atgatactat taagtattat     2340

tctatcattc ctcacagtat tcgttctatc caaagtgata gaaaagcttg ggctgccttc     2400

tacgtatata aacttcaacc gttaactttc ctgttggatt tttctgttga tggttatata     2460

cgcagagcta tagactgtgg ttttaatgat ttgtcacaac tccactgctc atatgaatcc     2520

ttcgatgttg aatctggagt ttattcagtt tcgtctttcg aagcaaaacc ttctggctca     2580

gttgtggaac aggctgaagg tgttgaatgt gatttttcac ctcttctgtc tggcacacct     2640

cctcaggttt ataatttcaa gcgtttggtt tttaccaatt gcaattataa tcttaccaaa     2700

ttgctttcac ttttttctgt gaatgatttt acttgtagtc aaatatctcc agcagcaatt     2760

gctagcaact gttattcttc actgattttg gattactttt catacccact tagtatgaaa     2820

tccgatctca gtgttagttc tgctggtcca atatcccagt ttaattataa acagtccttt     2880

tctaatccca catgtttgat tttagcgact gttcctcata accttactac tattactaag     2940

cctcttaagt acagctatat taacaagtgc tctcgtcttc tttctgatga tcgtactgaa     3000

gtacctcagt tagtgaacgc taatcaatac tcaccctgtg tatccattgt cccatccact     3060

gtgtgggaag acggtgatta ttataggaaa caactatctc cacttgaagg tggtggctgg     3120

cttgttgcta gtggctcaac tgttgccatg actgagcaat tacagatggg ctttggtatt     3180

acagttcaat atggtacaga caccaatagt gtttgcccca agcttgaatt tgctaatgac     3240

acaaaaattg cctctcaatt aggcaattgc gtggaatatt ccctctatgg tgtttcgggc     3300

cgtggtgttt ttcagaattg cacagctgta ggtgttcgac agcagcgctt tgtttatgat     3360

gcgtaccaga atttagttgg ctattattct gatgatggca actactactg tttgcgtgct     3420

tgtgttagtg ttcctgtttc tgtcatctat gataaagaaa ctaaaaccca cgctactcta     3480

tttggtagtg ttgcatgtga acacatttct tctaccatgt ctcaatactc ccgttctacg     3540

cgatcaatgc ttaaacggcg agattctaca tatggccccc ttcagacacc tgttggttgt     3600

gtcctaggac ttgttaattc ctctttgttc gtagaggact gcaagttgcc tcttggtcaa     3660

tctctctgtg ctcttcctga cacacctagt actctcacac ctcgcagtgt gcgctctgtt     3720

ccaggtgaaa tgcgcttggc atccattgct tttaatcatc ctattcaggt tgatcaactt     3780

aatagtagtt attttaaatt aagtataccc actaattttt cctttggtgt gactcaggag     3840

tacattcaga caaccattca gaaagttact gttgattgta aacagtacgt ttgcaatggt     3900

ttccagaagt gtgagcaatt actgcgcgag tatggccagt tttgttccaa aataaaccag     3960

gctctccatg gtgccaattt acgccaggat gattctgtac gtaatttgtt tgcgagcgtg     4020

aaaagctctc aatcatctcc tatcatacca ggttttggag gtgactttaa tttgacactt     4080

ctagaacctg tttctatatc tactggcagt cgtagtgcac gtagtgctat tgaggatttg     4140

ctatttgaca aagtcactat agctgatcct ggttatatgc aaggttacga tgattgcatg     4200

cagcaaggtc cagcatcagc tcgtgatctt atttgtgctc aatatgtggc tggttacaaa     4260

gtattacctc ctcttatgga tgttaatatg gaagccgcgt atacttcatc tttgcttggc     4320

agcatagcag gtgttggctg gactgctggc ttatcctcct ttgctgctat tccatttgca     4380

cagagtatct tttataggtt aaacggtgtt ggcattactc aacaggttct ttcagagaac     4440

caaaagctta ttgccaataa gtttaatcag gctctgggag ctatgcaaac aggcttcact     4500

acaactaatg aagcttttca gaaggttcag gatgctgtga acaacaatgc acaggctcta     4560

tccaaattag ctagcgagct atctaatact tttggtgcta tttccgcctc tattggagac     4620

atcatacaac gtcttgatgt tctcgaacag gacgcccaaa tagacagact tattaatggc     4680

cgtttgacaa cactaaatgc ttttgttgca cagcagcttg ttcgttccga atcagctgct     4740

ctttccgctc aattggctaa agataaagtc aatgagtgtg tcaaggcaca atccaagcgt     4800

tctggatttt gcggtcaagg cacacatata gtgtcctttg ttgtaaatgc ccctaatggc     4860

ctttacttca tgcatgttgg ttattaccct agcaaccaca ttgaggttgt ttctgcttat     4920

ggtctttgcg atgcagctaa ccctactaat tgtatagccc ctgttaatgg ctactttatt     4980

aaaactaata acactaggat tgttgatgag tggtcatata ctggctcgtc cttctatgca     5040

cctgagccca ttacctccct taatactaag tatgttgcac cacaggtgac ataccaaaac     5100

atttctacta acctccctcc tcctcttctc ggcaattcca ccgggattga cttccaagat     5160

gagttggatg agtttttcaa aaatgttagc accagtatac ctaattttgg ttccctaaca     5220

cagattaata ctacattact cgatcttacc tacgagatgt tgtctcttca acaagttgtt     5280

aaagccctta atgagtctta catagacctt aaagagcttg gcaattatac ttattacaac     5340

aaatggccgt ggtacatttg gcttggtttc attgctgggc ttgttgcctt agctctatgc     5400

gtcttcttca tactgtgctg cactggttgt ggcacaaact gtatgggaaa acttaagtgt     5460

aatcgttgtt gtgatagata cgaggaatac gacctcgagc cgcataaggt tcatgttcac     5520

taattagcta gccatgaaaa aaactaacac ccctcctttc gaaccatccc aaacatgagc     5580

aagatctttg tcaatcctag tgctattaga gccggtctgg ccgatcttga gatggctgaa     5640

gaaactgttg atctgatcaa tagaaatatc gaagacaatc aggctcatct ccaaggggaa     5700

cccatagagg tggacaatct ccctgaggat atggggcgac ttcacctgga tgatggaaaa     5760

tcgcccaacc atggtgagat agccaaggtg ggagaaggca agtatcgaga ggactttcag     5820

atggatgaag gagaggatcc tagcttcctg ttccagtcat acctggaaaa tgttggagtc     5880

caaatagtca gacaaatgag gtcaggagag agatttctca agatatggtc acagaccgta     5940

gaagagatta tatcctatgt cgcggtcaac tttcccaacc ctccaggaaa gtcttcagag     6000

gataaatcaa cccagactac tggccgagag ctcaagaagg agacaacacc cactccttct     6060

cagagagaaa gccaatcatc gaaagccagg atggcggctc aaattgcttc tggccctcca     6120

gcccttgaat ggtcggctac caatgaagag gatgatctat cagtggaggc tgagatcgct     6180

caccagattg cagaaagttt ctccaaaaaa tataagtttc cctctcgatc ctcagggata     6240

ctcttgtata attttgagca attgaaaatg aaccttgatg atatagttaa agaggcaaaa     6300

aatgtaccag gtgtgacccg tttagcccat gacgggtcca aactccccct aagatgtgta     6360

ctgggatggg tcgctttggc caactctaag aaattccagt tgttagtcga atccgacaag     6420

ctgagtaaaa tcatgcaaga tgacttgaat cgctatacat cttgctaacc gaacctctcc     6480

cctcagtccc tctagacaat aaaatccgag atgtcccaaa gtcaacatga aaaaaacagg     6540

caacaccact gataaaatga acctcctacg taagatagtg aaaaaccgca gggacgagga     6600

cactcaaaaa tcctctcccg cgtcagcccc tctggatgac gatgacttgt ggcttccacc     6660

ccctgaatac gtcccgctga aagaacttac aggcaagaag aacatgagga acttttgtat     6720

caacggaagg gttaaagtgt gtagcccgaa tggttactcg ttcaggatcc tgcggcacat     6780

tctgaaatca ttcgacgaga tatattctgg gaatcatagg atgatcgggt tagtcaaagt     6840

ggttattgga ctggctttgt caggatctcc agtccctgag ggcctgaact gggtatacaa     6900

attgaggaga acctttatct tccagtgggc tgattccagg ggccctcttg aaggggagga     6960

gttggaatac tctcaggaga tcacttggga tgatgatact gagttcgtcg gattgcaaat     7020

aagagtgatt gcaaaacagt gtcatatcca gggcagagtc tggtgtatca acatgaaccc     7080

gagagcatgt caactatggt ctgacatgtc tcttcagaca caaaggtccg aagaggacaa     7140

agattcctct ctgcttctag aataatcaga ttatatcccg caaatttatc acttgtttac     7200

ctctggagga gagaacatat gggctcaact ccaacccttg ggagcaatat aacaaaaaac     7260

atgttatggt gccattaaac cgctgcattt catcaaagtc aagttgatta cctttacatt     7320

ttgatcctct tggatgtgaa aaaaactatt aacatccctc aaaagacccc gggaaagatg     7380

gttcctcagg ctctcctgtt tgtacccctt ctggtttttc cattgtgttt tgggaaattc     7440

cctatttaca cgataccaga caagcttggt ccctggagtc cgattgacat acatcacctc     7500

agctgcccaa acaatttggt agtggaggac gaaggatgca ccaacctgtc agggttctcc     7560

tacatggaac ttaaagttgg atacatctta gccataaaag tgaacgggtt cacttgcaca     7620

ggcgttgtga cggaggctga aacctacact aacttcgttg gttatgtcac aaccacgttc     7680

aaaagaaagc atttccgccc aacaccagat gcatgtagag ccgcgtacaa ctggaagatg     7740

gccggtgacc ccagatatga agagtctcta cacaatccgt accctgacta ccgctggctt     7800

cgaactgtaa aaaccaccaa ggagtctctc gttatcatat ctccaagtgt ggcagatttg     7860

gacccatatg acagatccct tcactcgagg gtcttcccta gcgggaagtg ctcaggagta     7920

gcggtgtctt ctacctactg ctccactaac cacgattaca ccatttggat gcccgagaat     7980

ccgagactag ggatgtcttg tgacattttt accaatagta gagggaagag agcatccaaa     8040

gggagtgaga cttgcggctt tgtagatgaa agaggcctat ataagtcttt aaaaggagca     8100

tgcaaactca agttatgtgg agttctagga cttagactta tggatggaac atgggtctcg     8160

atgcaaacat caaatgaaac caaatggtgc cctcccgata agttggtgaa cctgcacgac     8220

tttcgctcag acgaaattga gcaccttgtt gtagaggagt tggtcaggaa gagagaggag     8280

tgtctggatg cactagagtc catcatgaca accaagtcag tgagtttcag acgtctcagt     8340

catttaagaa aacttgtccc tgggtttgga aaagcatata ccatattcaa caagaccttg     8400

atggaagccg atgctcacta caagtcagtc gagacttgga atgagatcct cccttcaaaa     8460

gggtgtttaa gagttggggg gaggtgtcat cctcatgtga acggggtgtt tttcaatggt     8520

ataatattag gacctgacgg caatgtctta atcccagaga tgcaatcatc cctcctccag     8580

caacatatgg agttgttgga atcctcggtt atcccccttg tgcaccccct ggcagacccg     8640

tctaccgttt tcaaggacgg tgacgaggct gaggattttg ttgaagttca ccttcccgat     8700

gtgcacaatc aggtctcagg agttgacttg ggtctcccga actgggggaa gtatgtatta     8760

ctgagtgcag gggccctgac tgccttgatg ttgataattt tcctgatgac atgttgtaga     8820

agagtcaatc gatcagaacc tacgcaacac aatctcagag ggacagggag ggaggtgtca     8880

gtcactcccc aaagcgggaa gatcatatct tcatgggaat cacacaagag tgggggtgag     8940

accagactgt aattaattaa cgtcctttca acgatccaag tccatgaaaa aaactaacac     9000

ccctcccgta cctagcttat aaagtgctgg gtcatctaag cttttcagtc gagaaaaaaa     9060

cattagatca gaagaacaac tggcaacact tctcaacctg agacttactt caagatgctc     9120

gatcctggag aggtctatga tgaccctatt gacccaatcg agttagaggc tgaacccaga     9180

ggaaccccca ttgtccccaa catcttgagg aactctgact acaatctcaa ctctcctttg     9240

atagaagatc ctgctagact aatgttagaa tggttaaaaa cagggaatag accttatcgg     9300

atgactctaa cagacaattg ctccaggtct ttcagagttt tgaaagatta tttcaagaag     9360

gtagatttgg gttctctcaa ggtgggcgga atggctgcac agtcaatgat ttctctctgg     9420

ttatatggtg cccactctga atccaacagg agccggagat gtataacaga cttggcccat     9480

ttctattcca agtcgtcccc catagagaag ctgttgaatc tcacgctagg aaatagaggg     9540

ctgagaatcc ccccagaggg agtgttaagt tgccttgaga gggttgatta tgataatgca     9600

tttggaaggt atcttgccaa cacgtattcc tcttacttgt tcttccatgt aatcacctta     9660

tacatgaacg ccctagactg ggatgaagaa aagaccatcc tagcattatg gaaagattta     9720

acctcagtgg acatcgggaa ggacttggta aagttcaaag accaaatatg gggactgctg     9780

atcgtgacaa aggactttgt ttactcccaa agttccaatt gtctttttga cagaaactac     9840

acacttatgc taaaagatct tttcttgtct cgcttcaact ccttaatggt cttgctctct     9900

cccccagagc cccgatactc agatgacttg atatctcaac tatgccagct gtacattgct     9960

ggggatcaag tcttgtctat gtgtggaaac tccggctatg aagtcatcaa aatattggag    10020

ccatatgtcg tgaatagttt agtccagaga gcagaaaagt ttaggcctct cattcattcc    10080

ttgggagact ttcctgtatt tataaaagac aaggtaagtc aacttgaaga gacgttcggt    10140

ccctgtgcaa gaaggttctt tagggctctg gatcaattcg acaacataca tgacttggtt    10200

tttgtgtttg gctgttacag gcattggggg cacccatata tagattatcg aaagggtctg    10260

tcaaaactat atgatcaggt tcaccttaaa aaaatgatag ataagtccta ccaggagtgc    10320

ttagcaagcg acctagccag gaggatcctt agatggggtt ttgataagta ctccaagtgg    10380

tatctggatt caagattcct agcccgagac caccccttga ctccttatat caaaacccaa    10440

acatggccac ccaaacatat tgtagacttg gtgggggata catggcacaa gctcccgatc    10500

acgcagatct ttgagattcc tgaatcaatg gatccgtcag aaatattgga tgacaaatca    10560

cattctttca ccagaacgag actagcttct tggctgtcag aaaaccgagg ggggcctgtt    10620

cctagcgaaa aagttattat cacggccctg tctaagccgc ctgtcaatcc ccgagagttt    10680

ctgaggtcta tagacctcgg aggattgcca gatgaagact tgataattgg cctcaagcca    10740

aaggaacggg aattgaagat tgaaggtcga ttctttgctc taatgtcatg gaatctaaga    10800

ttgtattttg tcatcactga aaaactcttg gccaactaca tcttgccact ttttgacgcg    10860

ctgactatga cagacaacct gaacaaggtg tttaaaaagc tgatcgacag ggtcaccggg    10920

caagggcttt tggactattc aagggtcaca tatgcatttc acctggacta tgaaaagtgg    10980

aacaaccatc aaagattaga gtcaacagag gatgtatttt ctgtcctaga tcaagtgttt    11040

ggattgaaga gagtgttttc tagaacacac gagttttttc aaaaggcctg gatctattat    11100

tcagacagat cagacctcat cgggttacgg gaggatcaaa tatactgctt agatgcgtcc    11160

aacggcccaa cctgttggaa tggccaggat ggcgggctag aaggcttacg gcagaagggc    11220

tggagtctag tcagcttatt gatgatagat agagaatctc aaatcaggaa cacaagaacc    11280

aaaatactag ctcaaggaga caaccaggtt ttatgtccga catacatgtt gtcgccaggg    11340

ctatctcaag aggggctcct ctatgaattg gagagaatat caaggaatgc actttcgata    11400

tacagagccg tcgaggaagg ggcatctaag ctagggctga tcatcaagaa agaagagacc    11460

atgtgtagtt atgacttcct catctatgga aaaacccctt tgtttagagg taacatattg    11520

gtgcctgagt ccaaaagatg ggccagagtc tcttgcgtct ctaatgacca aatagtcaac    11580

ctcgccaata taatgtcgac agtgtccacc aatgcgctaa cagtggcaca acactctcaa    11640

tctttgatca aaccgatgag ggattttctg ctcatgtcag tacaggcagt ctttcactac    11700

ctgctattta gcccaatctt aaagggaaga gtttacaaga ttctgagcgc tgaaggggag    11760

agctttctcc tagccatgtc aaggataatc tatctagatc cttctttggg agggatatct    11820

ggaatgtccc tcggaagatt ccatatacga cagttctcag accctgtctc tgaagggtta    11880

tccttctgga gagagatctg gttaagctcc caagagtcct ggattcacgc gttgtgtcaa    11940

gaggctggaa acccagatct tggagagaga acactcgaga gcttcactcg ccttctagaa    12000

gatccgacca ccttaaatat cagaggaggg gccagtccta ccattctact caaggatgca    12060

atcagaaagg ctttatatga cgaggtggac aaggtggaaa attcagagtt tcgagaggca    12120

atcctgttgt ccaagaccca tagagataat tttatactct tcttaatatc tgttgagcct    12180

ctgtttcctc gatttctcag tgagctattc agttcgtctt ttttgggaat ccccgagtca    12240

atcattggat tgatacaaaa ctcccgaacg ataagaaggc agtttagaaa gagtctctca    12300

aaaactttag aagaatcctt ctacaactca gagatccacg ggattagtcg gatgacccag    12360

acacctcaga gggttggggg ggtgtggcct tgctcttcag agagggcaga tctacttagg    12420

gagatctctt ggggaagaaa agtggtaggc acgacagttc ctcacccttc tgagatgttg    12480

ggattacttc ccaagtcctc tatttcttgc acttgtggag caacaggagg aggcaatcct    12540

agagtttctg tatcagtact cccgtccttt gatcagtcat ttttttcacg aggcccccta    12600

aagggatact tgggctcgtc cacctctatg tcgacccagc tattccatgc atgggaaaaa    12660

gtcactaatg ttcatgtggt gaagagagct ctatcgttaa aagaatctat aaactggttc    12720

attactagag attccaactt ggctcaagct ctaattagga acattatgtc tctgacaggc    12780

cctgatttcc ctctagagga ggcccctgtc ttcaaaagga cggggtcagc cttgcatagg    12840

ttcaagtctg ccagatacag cgaaggaggg tattcttctg tctgcccgaa cctcctctct    12900

catatttctg ttagtacaga caccatgtct gatttgaccc aagacgggaa gaactacgat    12960

ttcatgttcc agccattgat gctttatgca cagacatgga catcagagct ggtacagaga    13020

gacacaaggc taagagactc tacgtttcat tggcacctcc gatgcaacag gtgtgtgaga    13080

cccattgacg acgtgaccct ggagacctct cagatcttcg agtttccgga tgtgtcgaaa    13140

agaatatcca gaatggtttc tggggctgtg cctcacttcc agaggcttcc cgatatccgt    13200

ctgagaccag gagattttga atctctaagc ggtagagaaa agtctcacca tatcggatca    13260

gctcaggggc tcttatactc aatcttagtg gcaattcacg actcaggata caatgatgga    13320

accatcttcc ctgtcaacat atacggcaag gtttccccta gagactattt gagagggctc    13380

gcaaggggag tattgatagg atcctcgatt tgcttcttga caagaatgac aaatatcaat    13440

attaatagac ctcttgaatt ggtctcaggg gtaatctcat atattctcct gaggctagat    13500

aaccatccct ccttgtacat aatgctcaga gaaccgtctc ttagaggaga gatattttct    13560

atccctcaga aaatccccgc cgcttatcca accactatga aagaaggcaa cagatcaatc    13620

ttgtgttatc tccaacatgt gctacgctat gagcgagaga taatcacggc gtctccagag    13680

aatgactggc tatggatctt ttcagacttt agaagtgcca aaatgacgta cctatccctc    13740

attacttacc agtctcatct tctactccag agggttgaga gaaacctatc taagagtatg    13800

agagataacc tgcgacaatt gagttctttg atgaggcagg tgctgggcgg gcacggagaa    13860

gataccttag agtcagacga caacattcaa cgactgctaa aagactcttt acgaaggaca    13920

agatgggtgg atcaagaggt gcgccatgca gctagaacca tgactggaga ttacagcccc    13980

aacaagaagg tgtcccgtaa ggtaggatgt tcagaatggg tctgctctgc tcaacaggtt    14040

gcagtctcta cctcagcaaa cccggcccct gtctcggagc ttgacataag ggccctctct    14100

aagaggttcc agaacccttt gatctcgggc ttgagagtgg ttcagtgggc aaccggtgct    14160

cattataagc ttaagcctat tctagatgat ctcaatgttt tcccatctct ctgccttgta    14220

gttggggacg ggtcaggggg gatatcaagg gcagtcctca acatgtttcc agatgccaag    14280

cttgtgttca acagtctttt agaggtgaat gacctgatgg cttccggaac acatccactg    14340

cctccttcag caatcatgag gggaggaaat gatatcgtct ccagagtgat agatcttgac    14400

tcaatctggg aaaaaccgtc cgacttgaga aacttggcaa cctggaaata cttccagtca    14460

gtccaaaagc aggtcaacat gtcctatgac ctcattattt gcgatgcaga agttactgac    14520

attgcatcta tcaaccggat caccctgtta atgtccgatt ttgcattgtc tatagatgga    14580

ccactctatt tggtcttcaa aacttatggg actatgctag taaatccaaa ctacaaggct    14640

attcaacacc tgtcaagagc gttcccctcg gtcacagggt ttatcaccca agtaacttcg    14700

tctttttcat ctgagctcta cctccgattc tccaaacgag ggaagttttt cagagatgct    14760

gagtacttga cctcttccac ccttcgagaa atgagccttg tgttattcaa ttgtagcagc    14820

cccaagagtg agatgcagag agctcgttcc ttgaactatc aggatcttgt gagaggattt    14880

cctgaagaaa tcatatcaaa tccttacaat gagatgatca taactctgat tgacagtgat    14940

gtagaatctt ttctagtcca caagatggtt gatgatcttg agttacagag gggaactctg    15000

tctaaagtgg ctatcattat agccatcatg atagttttct ccaacagagt cttcaacgtt    15060

tccaaacccc taactgaccc ctcgttctat ccaccgtctg atcccaaaat cctgaggcac    15120

ttcaacatat gttgcagtac tatgatgtat ctatctactg ctttaggtga cgtccctagc    15180

ttcgcaagac ttcacgacct gtataacaga cctataactt attacttcag aaagcaagtc    15240

attcgaggga acgtttatct atcttggagt tggtccaacg acacctcagt gttcaaaagg    15300

gtagcctgta attctagcct gagtctgtca tctcactgga tcaggttgat ttacaagata    15360

gtgaagacta ccagactcgt tggcagcatc aaggatctat ccagagaagt ggaaagacac    15420

cttcataggt acaacaggtg gatcacccta gaggatatca gatctagatc atccctacta    15480

gactacagtt gcctgtgaac cggatactcc tggaagcctg cccatgctaa gactcttgtg    15540

tgatgtatct tgaaaaaaac aagatcctaa atctgaacct ttggttgttt gattgttttt    15600

ctcatttttg ttgtttattt gttaagcgt                                      15629


<210>  23
<211>  15539
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Recombinant Rabies virus vector BNSP333 expressing a Middle East 
       Respiratory Syndrome Coronavirus spike glycoprotein with a 29 
       amino acid C-terminal truncation

<400>  23
acgcttaaca accagatcaa agaaaaaaca gacattgtca attgcaaagc aaaaatgtaa       60

cacccctaca atggatgccg acaagattgt attcaaagtc aataatcagg tggtctcttt      120

gaagcctgag attatcgtgg atcaatatga gtacaagtac cctgccatca aagatttgaa      180

aaagccctgt ataaccctag gaaaggctcc cgatttaaat aaagcataca agtcagtttt      240

gtcaggcatg agcgccgcca aacttaatcc tgacgatgta tgttcctatt tggcagcggc      300

aatgcagttt tttgagggga catgtccgga agactggacc agctatggaa ttgtgattgc      360

acgaaaagga gataagatca ccccaggttc tctggtggag ataaaacgta ctgatgtaga      420

agggaattgg gctctgacag gaggcatgga actgacaaga gaccccactg tccctgagca      480

tgcgtcctta gtcggtcttc tcttgagtct gtataggttg agcaaaatat ccgggcaaaa      540

cactggtaac tataagacaa acattgcaga caggatagag cagatttttg agacagcccc      600

ttttgttaaa atcgtggaac accatactct aatgacaact cacaaaatgt gtgctaattg      660

gagtactata ccaaacttca gatttttggc cggaacctat gacatgtttt tctcccggat      720

tgagcatcta tattcagcaa tcagagtggg cacagttgtc actgcttatg aagactgttc      780

aggactggta tcatttactg ggttcataaa acaaatcaat ctcaccgcta gagaggcaat      840

actatatttc ttccacaaga actttgagga agagataaga agaatgtttg agccagggca      900

ggagacagct gttcctcact cttatttcat ccacttccgt tcactaggct tgagtgggaa      960

atctccttat tcatcaaatg ctgttggtca cgtgttcaat ctcattcact ttgtaggatg     1020

ctatatgggt caagtcagat ccctaaatgc aacggttatt gctgcatgtg ctcctcatga     1080

aatgtctgtt ctagggggct atctgggaga ggaattcttc gggaaaggga catttgaaag     1140

aagattcttc agagatgaga aagaacttca agaatacgag gcggctgaac tgacaaagac     1200

tgacgtagca ctggcagatg atggaactgt caactctgac gacgaggact acttttcagg     1260

tgaaaccaga agtccggagg ctgtttatac tcgaatcatg atgaatggag gtcgactaaa     1320

gagatctcac atacggagat atgtctcagt cagttccaat catcaagccc gtccaaactc     1380

attcgccgag tttctaaaca agacatattc gagtgactca taacatgaaa aaaactaaca     1440

cccctcccgt acgccgccac catgatacac tcagtgtttc tactgatgtt cttgttaaca     1500

cctacagaaa gttacgttga tgtagggcca gattctgtta agtctgcttg tattgaggtt     1560

gatatacaac agactttctt tgataaaact tggcctaggc caattgatgt ttctaaggct     1620

gacggtatta tataccctca aggccgtaca tattctaaca taactatcac ttatcaaggt     1680

ctttttccct atcagggaga ccatggtgat atgtatgttt actctgcagg acatgctaca     1740

ggcacaactc cacaaaagtt gtttgtagct aactattctc aggacgtcaa acagtttgct     1800

aatgggtttg tcgtccgtat aggagcagct gccaattcca ctggcactgt tattattagc     1860

ccatctacca gcgctactat acgaaaaatt taccctgctt ttatgctggg ttcttcagtt     1920

ggtaatttct cagatggtaa aatgggccgc ttcttcaatc atactctagt tcttttgccc     1980

gatggatgtg gcactttact tagagctttt tattgtattc tagagcctcg ctctggaaat     2040

cattgtcctg ctggcaattc ctatacttct tttgccactt atcacactcc tgcaacagat     2100

tgttctgatg gcaattacaa tcgtaatgcc agtctgaact cttttaagga gtattttaat     2160

ttacgtaact gcacctttat gtacacttat aacattaccg aagatgagat tttagagtgg     2220

tttggcatta cacaaactgc tcaaggtgtt cacctcttct catctcggta tgttgatttg     2280

tacggcggca atatgtttca atttgccacc ttgcctgttt atgatactat taagtattat     2340

tctatcattc ctcacagtat tcgttctatc caaagtgata gaaaagcttg ggctgccttc     2400

tacgtatata aacttcaacc gttaactttc ctgttggatt tttctgttga tggttatata     2460

cgcagagcta tagactgtgg ttttaatgat ttgtcacaac tccactgctc atatgaatcc     2520

ttcgatgttg aatctggagt ttattcagtt tcgtctttcg aagcaaaacc ttctggctca     2580

gttgtggaac aggctgaagg tgttgaatgt gatttttcac ctcttctgtc tggcacacct     2640

cctcaggttt ataatttcaa gcgtttggtt tttaccaatt gcaattataa tcttaccaaa     2700

ttgctttcac ttttttctgt gaatgatttt acttgtagtc aaatatctcc agcagcaatt     2760

gctagcaact gttattcttc actgattttg gattactttt catacccact tagtatgaaa     2820

tccgatctca gtgttagttc tgctggtcca atatcccagt ttaattataa acagtccttt     2880

tctaatccca catgtttgat tttagcgact gttcctcata accttactac tattactaag     2940

cctcttaagt acagctatat taacaagtgc tctcgtcttc tttctgatga tcgtactgaa     3000

gtacctcagt tagtgaacgc taatcaatac tcaccctgtg tatccattgt cccatccact     3060

gtgtgggaag acggtgatta ttataggaaa caactatctc cacttgaagg tggtggctgg     3120

cttgttgcta gtggctcaac tgttgccatg actgagcaat tacagatggg ctttggtatt     3180

acagttcaat atggtacaga caccaatagt gtttgcccca agcttgaatt tgctaatgac     3240

acaaaaattg cctctcaatt aggcaattgc gtggaatatt ccctctatgg tgtttcgggc     3300

cgtggtgttt ttcagaattg cacagctgta ggtgttcgac agcagcgctt tgtttatgat     3360

gcgtaccaga atttagttgg ctattattct gatgatggca actactactg tttgcgtgct     3420

tgtgttagtg ttcctgtttc tgtcatctat gataaagaaa ctaaaaccca cgctactcta     3480

tttggtagtg ttgcatgtga acacatttct tctaccatgt ctcaatactc ccgttctacg     3540

cgatcaatgc ttaaacggcg agattctaca tatggccccc ttcagacacc tgttggttgt     3600

gtcctaggac ttgttaattc ctctttgttc gtagaggact gcaagttgcc tcttggtcaa     3660

tctctctgtg ctcttcctga cacacctagt actctcacac ctcgcagtgt gcgctctgtt     3720

ccaggtgaaa tgcgcttggc atccattgct tttaatcatc ctattcaggt tgatcaactt     3780

aatagtagtt attttaaatt aagtataccc actaattttt cctttggtgt gactcaggag     3840

tacattcaga caaccattca gaaagttact gttgattgta aacagtacgt ttgcaatggt     3900

ttccagaagt gtgagcaatt actgcgcgag tatggccagt tttgttccaa aataaaccag     3960

gctctccatg gtgccaattt acgccaggat gattctgtac gtaatttgtt tgcgagcgtg     4020

aaaagctctc aatcatctcc tatcatacca ggttttggag gtgactttaa tttgacactt     4080

ctagaacctg tttctatatc tactggcagt cgtagtgcac gtagtgctat tgaggatttg     4140

ctatttgaca aagtcactat agctgatcct ggttatatgc aaggttacga tgattgcatg     4200

cagcaaggtc cagcatcagc tcgtgatctt atttgtgctc aatatgtggc tggttacaaa     4260

gtattacctc ctcttatgga tgttaatatg gaagccgcgt atacttcatc tttgcttggc     4320

agcatagcag gtgttggctg gactgctggc ttatcctcct ttgctgctat tccatttgca     4380

cagagtatct tttataggtt aaacggtgtt ggcattactc aacaggttct ttcagagaac     4440

caaaagctta ttgccaataa gtttaatcag gctctgggag ctatgcaaac aggcttcact     4500

acaactaatg aagcttttca gaaggttcag gatgctgtga acaacaatgc acaggctcta     4560

tccaaattag ctagcgagct atctaatact tttggtgcta tttccgcctc tattggagac     4620

atcatacaac gtcttgatgt tctcgaacag gacgcccaaa tagacagact tattaatggc     4680

cgtttgacaa cactaaatgc ttttgttgca cagcagcttg ttcgttccga atcagctgct     4740

ctttccgctc aattggctaa agataaagtc aatgagtgtg tcaaggcaca atccaagcgt     4800

tctggatttt gcggtcaagg cacacatata gtgtcctttg ttgtaaatgc ccctaatggc     4860

ctttacttca tgcatgttgg ttattaccct agcaaccaca ttgaggttgt ttctgcttat     4920

ggtctttgcg atgcagctaa ccctactaat tgtatagccc ctgttaatgg ctactttatt     4980

aaaactaata acactaggat tgttgatgag tggtcatata ctggctcgtc cttctatgca     5040

cctgagccca ttacctccct taatactaag tatgttgcac cacaggtgac ataccaaaac     5100

atttctacta acctccctcc tcctcttctc ggcaattcca ccgggattga cttccaagat     5160

gagttggatg agtttttcaa aaatgttagc accagtatac ctaattttgg ttccctaaca     5220

cagattaata ctacattact cgatcttacc tacgagatgt tgtctcttca acaagttgtt     5280

aaagccctta atgagtctta catagacctt aaagagcttg gcaattatac ttattacaac     5340

aaatggccgt ggtacatttg gcttggtttc attgctgggc ttgttgcctt agctctatgc     5400

gtcttcttca tactgtgctg cactggttgt ggctaagcta gtcatgaaaa aaactaacac     5460

ccctcctttc gaaccatccc aaacatgagc aagatctttg tcaatcctag tgctattaga     5520

gccggtctgg ccgatcttga gatggctgaa gaaactgttg atctgatcaa tagaaatatc     5580

gaagacaatc aggctcatct ccaaggggaa cccatagagg tggacaatct ccctgaggat     5640

atggggcgac ttcacctgga tgatggaaaa tcgcccaacc atggtgagat agccaaggtg     5700

ggagaaggca agtatcgaga ggactttcag atggatgaag gagaggatcc tagcttcctg     5760

ttccagtcat acctggaaaa tgttggagtc caaatagtca gacaaatgag gtcaggagag     5820

agatttctca agatatggtc acagaccgta gaagagatta tatcctatgt cgcggtcaac     5880

tttcccaacc ctccaggaaa gtcttcagag gataaatcaa cccagactac tggccgagag     5940

ctcaagaagg agacaacacc cactccttct cagagagaaa gccaatcatc gaaagccagg     6000

atggcggctc aaattgcttc tggccctcca gcccttgaat ggtcggctac caatgaagag     6060

gatgatctat cagtggaggc tgagatcgct caccagattg cagaaagttt ctccaaaaaa     6120

tataagtttc cctctcgatc ctcagggata ctcttgtata attttgagca attgaaaatg     6180

aaccttgatg atatagttaa agaggcaaaa aatgtaccag gtgtgacccg tttagcccat     6240

gacgggtcca aactccccct aagatgtgta ctgggatggg tcgctttggc caactctaag     6300

aaattccagt tgttagtcga atccgacaag ctgagtaaaa tcatgcaaga tgacttgaat     6360

cgctatacat cttgctaacc gaacctctcc cctcagtccc tctagacaat aaaatccgag     6420

atgtcccaaa gtcaacatga aaaaaacagg caacaccact gataaaatga acctcctacg     6480

taagatagtg aaaaaccgca gggacgagga cactcaaaaa tcctctcccg cgtcagcccc     6540

tctggatgac gatgacttgt ggcttccacc ccctgaatac gtcccgctga aagaacttac     6600

aggcaagaag aacatgagga acttttgtat caacggaagg gttaaagtgt gtagcccgaa     6660

tggttactcg ttcaggatcc tgcggcacat tctgaaatca ttcgacgaga tatattctgg     6720

gaatcatagg atgatcgggt tagtcaaagt ggttattgga ctggctttgt caggatctcc     6780

agtccctgag ggcctgaact gggtatacaa attgaggaga acctttatct tccagtgggc     6840

tgattccagg ggccctcttg aaggggagga gttggaatac tctcaggaga tcacttggga     6900

tgatgatact gagttcgtcg gattgcaaat aagagtgatt gcaaaacagt gtcatatcca     6960

gggcagagtc tggtgtatca acatgaaccc gagagcatgt caactatggt ctgacatgtc     7020

tcttcagaca caaaggtccg aagaggacaa agattcctct ctgcttctag aataatcaga     7080

ttatatcccg caaatttatc acttgtttac ctctggagga gagaacatat gggctcaact     7140

ccaacccttg ggagcaatat aacaaaaaac atgttatggt gccattaaac cgctgcattt     7200

catcaaagtc aagttgatta cctttacatt ttgatcctct tggatgtgaa aaaaactatt     7260

aacatccctc aaaagacccc gggaaagatg gttcctcagg ctctcctgtt tgtacccctt     7320

ctggtttttc cattgtgttt tgggaaattc cctatttaca cgataccaga caagcttggt     7380

ccctggagtc cgattgacat acatcacctc agctgcccaa acaatttggt agtggaggac     7440

gaaggatgca ccaacctgtc agggttctcc tacatggaac ttaaagttgg atacatctta     7500

gccataaaag tgaacgggtt cacttgcaca ggcgttgtga cggaggctga aacctacact     7560

aacttcgttg gttatgtcac aaccacgttc aaaagaaagc atttccgccc aacaccagat     7620

gcatgtagag ccgcgtacaa ctggaagatg gccggtgacc ccagatatga agagtctcta     7680

cacaatccgt accctgacta ccgctggctt cgaactgtaa aaaccaccaa ggagtctctc     7740

gttatcatat ctccaagtgt ggcagatttg gacccatatg acagatccct tcactcgagg     7800

gtcttcccta gcgggaagtg ctcaggagta gcggtgtctt ctacctactg ctccactaac     7860

cacgattaca ccatttggat gcccgagaat ccgagactag ggatgtcttg tgacattttt     7920

accaatagta gagggaagag agcatccaaa gggagtgaga cttgcggctt tgtagatgaa     7980

agaggcctat ataagtcttt aaaaggagca tgcaaactca agttatgtgg agttctagga     8040

cttagactta tggatggaac atgggtctcg atgcaaacat caaatgaaac caaatggtgc     8100

cctcccgata agttggtgaa cctgcacgac tttcgctcag acgaaattga gcaccttgtt     8160

gtagaggagt tggtcaggaa gagagaggag tgtctggatg cactagagtc catcatgaca     8220

accaagtcag tgagtttcag acgtctcagt catttaagaa aacttgtccc tgggtttgga     8280

aaagcatata ccatattcaa caagaccttg atggaagccg atgctcacta caagtcagtc     8340

gagacttgga atgagatcct cccttcaaaa gggtgtttaa gagttggggg gaggtgtcat     8400

cctcatgtga acggggtgtt tttcaatggt ataatattag gacctgacgg caatgtctta     8460

atcccagaga tgcaatcatc cctcctccag caacatatgg agttgttgga atcctcggtt     8520

atcccccttg tgcaccccct ggcagacccg tctaccgttt tcaaggacgg tgacgaggct     8580

gaggattttg ttgaagttca ccttcccgat gtgcacaatc aggtctcagg agttgacttg     8640

ggtctcccga actgggggaa gtatgtatta ctgagtgcag gggccctgac tgccttgatg     8700

ttgataattt tcctgatgac atgttgtaga agagtcaatc gatcagaacc tacgcaacac     8760

aatctcagag ggacagggag ggaggtgtca gtcactcccc aaagcgggaa gatcatatct     8820

tcatgggaat cacacaagag tgggggtgag accagactgt aattaattaa cgtcctttca     8880

acgatccaag tccatgaaaa aaactaacac ccctcccgta cctagcttat aaagtgctgg     8940

gtcatctaag cttttcagtc gagaaaaaaa cattagatca gaagaacaac tggcaacact     9000

tctcaacctg agacttactt caagatgctc gatcctggag aggtctatga tgaccctatt     9060

gacccaatcg agttagaggc tgaacccaga ggaaccccca ttgtccccaa catcttgagg     9120

aactctgact acaatctcaa ctctcctttg atagaagatc ctgctagact aatgttagaa     9180

tggttaaaaa cagggaatag accttatcgg atgactctaa cagacaattg ctccaggtct     9240

ttcagagttt tgaaagatta tttcaagaag gtagatttgg gttctctcaa ggtgggcgga     9300

atggctgcac agtcaatgat ttctctctgg ttatatggtg cccactctga atccaacagg     9360

agccggagat gtataacaga cttggcccat ttctattcca agtcgtcccc catagagaag     9420

ctgttgaatc tcacgctagg aaatagaggg ctgagaatcc ccccagaggg agtgttaagt     9480

tgccttgaga gggttgatta tgataatgca tttggaaggt atcttgccaa cacgtattcc     9540

tcttacttgt tcttccatgt aatcacctta tacatgaacg ccctagactg ggatgaagaa     9600

aagaccatcc tagcattatg gaaagattta acctcagtgg acatcgggaa ggacttggta     9660

aagttcaaag accaaatatg gggactgctg atcgtgacaa aggactttgt ttactcccaa     9720

agttccaatt gtctttttga cagaaactac acacttatgc taaaagatct tttcttgtct     9780

cgcttcaact ccttaatggt cttgctctct cccccagagc cccgatactc agatgacttg     9840

atatctcaac tatgccagct gtacattgct ggggatcaag tcttgtctat gtgtggaaac     9900

tccggctatg aagtcatcaa aatattggag ccatatgtcg tgaatagttt agtccagaga     9960

gcagaaaagt ttaggcctct cattcattcc ttgggagact ttcctgtatt tataaaagac    10020

aaggtaagtc aacttgaaga gacgttcggt ccctgtgcaa gaaggttctt tagggctctg    10080

gatcaattcg acaacataca tgacttggtt tttgtgtttg gctgttacag gcattggggg    10140

cacccatata tagattatcg aaagggtctg tcaaaactat atgatcaggt tcaccttaaa    10200

aaaatgatag ataagtccta ccaggagtgc ttagcaagcg acctagccag gaggatcctt    10260

agatggggtt ttgataagta ctccaagtgg tatctggatt caagattcct agcccgagac    10320

caccccttga ctccttatat caaaacccaa acatggccac ccaaacatat tgtagacttg    10380

gtgggggata catggcacaa gctcccgatc acgcagatct ttgagattcc tgaatcaatg    10440

gatccgtcag aaatattgga tgacaaatca cattctttca ccagaacgag actagcttct    10500

tggctgtcag aaaaccgagg ggggcctgtt cctagcgaaa aagttattat cacggccctg    10560

tctaagccgc ctgtcaatcc ccgagagttt ctgaggtcta tagacctcgg aggattgcca    10620

gatgaagact tgataattgg cctcaagcca aaggaacggg aattgaagat tgaaggtcga    10680

ttctttgctc taatgtcatg gaatctaaga ttgtattttg tcatcactga aaaactcttg    10740

gccaactaca tcttgccact ttttgacgcg ctgactatga cagacaacct gaacaaggtg    10800

tttaaaaagc tgatcgacag ggtcaccggg caagggcttt tggactattc aagggtcaca    10860

tatgcatttc acctggacta tgaaaagtgg aacaaccatc aaagattaga gtcaacagag    10920

gatgtatttt ctgtcctaga tcaagtgttt ggattgaaga gagtgttttc tagaacacac    10980

gagttttttc aaaaggcctg gatctattat tcagacagat cagacctcat cgggttacgg    11040

gaggatcaaa tatactgctt agatgcgtcc aacggcccaa cctgttggaa tggccaggat    11100

ggcgggctag aaggcttacg gcagaagggc tggagtctag tcagcttatt gatgatagat    11160

agagaatctc aaatcaggaa cacaagaacc aaaatactag ctcaaggaga caaccaggtt    11220

ttatgtccga catacatgtt gtcgccaggg ctatctcaag aggggctcct ctatgaattg    11280

gagagaatat caaggaatgc actttcgata tacagagccg tcgaggaagg ggcatctaag    11340

ctagggctga tcatcaagaa agaagagacc atgtgtagtt atgacttcct catctatgga    11400

aaaacccctt tgtttagagg taacatattg gtgcctgagt ccaaaagatg ggccagagtc    11460

tcttgcgtct ctaatgacca aatagtcaac ctcgccaata taatgtcgac agtgtccacc    11520

aatgcgctaa cagtggcaca acactctcaa tctttgatca aaccgatgag ggattttctg    11580

ctcatgtcag tacaggcagt ctttcactac ctgctattta gcccaatctt aaagggaaga    11640

gtttacaaga ttctgagcgc tgaaggggag agctttctcc tagccatgtc aaggataatc    11700

tatctagatc cttctttggg agggatatct ggaatgtccc tcggaagatt ccatatacga    11760

cagttctcag accctgtctc tgaagggtta tccttctgga gagagatctg gttaagctcc    11820

caagagtcct ggattcacgc gttgtgtcaa gaggctggaa acccagatct tggagagaga    11880

acactcgaga gcttcactcg ccttctagaa gatccgacca ccttaaatat cagaggaggg    11940

gccagtccta ccattctact caaggatgca atcagaaagg ctttatatga cgaggtggac    12000

aaggtggaaa attcagagtt tcgagaggca atcctgttgt ccaagaccca tagagataat    12060

tttatactct tcttaatatc tgttgagcct ctgtttcctc gatttctcag tgagctattc    12120

agttcgtctt ttttgggaat ccccgagtca atcattggat tgatacaaaa ctcccgaacg    12180

ataagaaggc agtttagaaa gagtctctca aaaactttag aagaatcctt ctacaactca    12240

gagatccacg ggattagtcg gatgacccag acacctcaga gggttggggg ggtgtggcct    12300

tgctcttcag agagggcaga tctacttagg gagatctctt ggggaagaaa agtggtaggc    12360

acgacagttc ctcacccttc tgagatgttg ggattacttc ccaagtcctc tatttcttgc    12420

acttgtggag caacaggagg aggcaatcct agagtttctg tatcagtact cccgtccttt    12480

gatcagtcat ttttttcacg aggcccccta aagggatact tgggctcgtc cacctctatg    12540

tcgacccagc tattccatgc atgggaaaaa gtcactaatg ttcatgtggt gaagagagct    12600

ctatcgttaa aagaatctat aaactggttc attactagag attccaactt ggctcaagct    12660

ctaattagga acattatgtc tctgacaggc cctgatttcc ctctagagga ggcccctgtc    12720

ttcaaaagga cggggtcagc cttgcatagg ttcaagtctg ccagatacag cgaaggaggg    12780

tattcttctg tctgcccgaa cctcctctct catatttctg ttagtacaga caccatgtct    12840

gatttgaccc aagacgggaa gaactacgat ttcatgttcc agccattgat gctttatgca    12900

cagacatgga catcagagct ggtacagaga gacacaaggc taagagactc tacgtttcat    12960

tggcacctcc gatgcaacag gtgtgtgaga cccattgacg acgtgaccct ggagacctct    13020

cagatcttcg agtttccgga tgtgtcgaaa agaatatcca gaatggtttc tggggctgtg    13080

cctcacttcc agaggcttcc cgatatccgt ctgagaccag gagattttga atctctaagc    13140

ggtagagaaa agtctcacca tatcggatca gctcaggggc tcttatactc aatcttagtg    13200

gcaattcacg actcaggata caatgatgga accatcttcc ctgtcaacat atacggcaag    13260

gtttccccta gagactattt gagagggctc gcaaggggag tattgatagg atcctcgatt    13320

tgcttcttga caagaatgac aaatatcaat attaatagac ctcttgaatt ggtctcaggg    13380

gtaatctcat atattctcct gaggctagat aaccatccct ccttgtacat aatgctcaga    13440

gaaccgtctc ttagaggaga gatattttct atccctcaga aaatccccgc cgcttatcca    13500

accactatga aagaaggcaa cagatcaatc ttgtgttatc tccaacatgt gctacgctat    13560

gagcgagaga taatcacggc gtctccagag aatgactggc tatggatctt ttcagacttt    13620

agaagtgcca aaatgacgta cctatccctc attacttacc agtctcatct tctactccag    13680

agggttgaga gaaacctatc taagagtatg agagataacc tgcgacaatt gagttctttg    13740

atgaggcagg tgctgggcgg gcacggagaa gataccttag agtcagacga caacattcaa    13800

cgactgctaa aagactcttt acgaaggaca agatgggtgg atcaagaggt gcgccatgca    13860

gctagaacca tgactggaga ttacagcccc aacaagaagg tgtcccgtaa ggtaggatgt    13920

tcagaatggg tctgctctgc tcaacaggtt gcagtctcta cctcagcaaa cccggcccct    13980

gtctcggagc ttgacataag ggccctctct aagaggttcc agaacccttt gatctcgggc    14040

ttgagagtgg ttcagtgggc aaccggtgct cattataagc ttaagcctat tctagatgat    14100

ctcaatgttt tcccatctct ctgccttgta gttggggacg ggtcaggggg gatatcaagg    14160

gcagtcctca acatgtttcc agatgccaag cttgtgttca acagtctttt agaggtgaat    14220

gacctgatgg cttccggaac acatccactg cctccttcag caatcatgag gggaggaaat    14280

gatatcgtct ccagagtgat agatcttgac tcaatctggg aaaaaccgtc cgacttgaga    14340

aacttggcaa cctggaaata cttccagtca gtccaaaagc aggtcaacat gtcctatgac    14400

ctcattattt gcgatgcaga agttactgac attgcatcta tcaaccggat caccctgtta    14460

atgtccgatt ttgcattgtc tatagatgga ccactctatt tggtcttcaa aacttatggg    14520

actatgctag taaatccaaa ctacaaggct attcaacacc tgtcaagagc gttcccctcg    14580

gtcacagggt ttatcaccca agtaacttcg tctttttcat ctgagctcta cctccgattc    14640

tccaaacgag ggaagttttt cagagatgct gagtacttga cctcttccac ccttcgagaa    14700

atgagccttg tgttattcaa ttgtagcagc cccaagagtg agatgcagag agctcgttcc    14760

ttgaactatc aggatcttgt gagaggattt cctgaagaaa tcatatcaaa tccttacaat    14820

gagatgatca taactctgat tgacagtgat gtagaatctt ttctagtcca caagatggtt    14880

gatgatcttg agttacagag gggaactctg tctaaagtgg ctatcattat agccatcatg    14940

atagttttct ccaacagagt cttcaacgtt tccaaacccc taactgaccc ctcgttctat    15000

ccaccgtctg atcccaaaat cctgaggcac ttcaacatat gttgcagtac tatgatgtat    15060

ctatctactg ctttaggtga cgtccctagc ttcgcaagac ttcacgacct gtataacaga    15120

cctataactt attacttcag aaagcaagtc attcgaggga acgtttatct atcttggagt    15180

tggtccaacg acacctcagt gttcaaaagg gtagcctgta attctagcct gagtctgtca    15240

tctcactgga tcaggttgat ttacaagata gtgaagacta ccagactcgt tggcagcatc    15300

aaggatctat ccagagaagt ggaaagacac cttcataggt acaacaggtg gatcacccta    15360

gaggatatca gatctagatc atccctacta gactacagtt gcctgtgaac cggatactcc    15420

tggaagcctg cccatgctaa gactcttgtg tgatgtatct tgaaaaaaac aagatcctaa    15480

atctgaacct ttggttgttt gattgttttt ctcatttttg ttgtttattt gttaagcgt     15539


<210>  24
<211>  15569
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Recombinant Rabies virus vector BNSP333 expressing a Middle East 
       Respiratory Syndrome Coronavirus spike glycoprotein with a 19 
       amino acid C-terminal truncation

<400>  24
acgcttaaca accagatcaa agaaaaaaca gacattgtca attgcaaagc aaaaatgtaa       60

cacccctaca atggatgccg acaagattgt attcaaagtc aataatcagg tggtctcttt      120

gaagcctgag attatcgtgg atcaatatga gtacaagtac cctgccatca aagatttgaa      180

aaagccctgt ataaccctag gaaaggctcc cgatttaaat aaagcataca agtcagtttt      240

gtcaggcatg agcgccgcca aacttaatcc tgacgatgta tgttcctatt tggcagcggc      300

aatgcagttt tttgagggga catgtccgga agactggacc agctatggaa ttgtgattgc      360

acgaaaagga gataagatca ccccaggttc tctggtggag ataaaacgta ctgatgtaga      420

agggaattgg gctctgacag gaggcatgga actgacaaga gaccccactg tccctgagca      480

tgcgtcctta gtcggtcttc tcttgagtct gtataggttg agcaaaatat ccgggcaaaa      540

cactggtaac tataagacaa acattgcaga caggatagag cagatttttg agacagcccc      600

ttttgttaaa atcgtggaac accatactct aatgacaact cacaaaatgt gtgctaattg      660

gagtactata ccaaacttca gatttttggc cggaacctat gacatgtttt tctcccggat      720

tgagcatcta tattcagcaa tcagagtggg cacagttgtc actgcttatg aagactgttc      780

aggactggta tcatttactg ggttcataaa acaaatcaat ctcaccgcta gagaggcaat      840

actatatttc ttccacaaga actttgagga agagataaga agaatgtttg agccagggca      900

ggagacagct gttcctcact cttatttcat ccacttccgt tcactaggct tgagtgggaa      960

atctccttat tcatcaaatg ctgttggtca cgtgttcaat ctcattcact ttgtaggatg     1020

ctatatgggt caagtcagat ccctaaatgc aacggttatt gctgcatgtg ctcctcatga     1080

aatgtctgtt ctagggggct atctgggaga ggaattcttc gggaaaggga catttgaaag     1140

aagattcttc agagatgaga aagaacttca agaatacgag gcggctgaac tgacaaagac     1200

tgacgtagca ctggcagatg atggaactgt caactctgac gacgaggact acttttcagg     1260

tgaaaccaga agtccggagg ctgtttatac tcgaatcatg atgaatggag gtcgactaaa     1320

gagatctcac atacggagat atgtctcagt cagttccaat catcaagccc gtccaaactc     1380

attcgccgag tttctaaaca agacatattc gagtgactca taacatgaaa aaaactaaca     1440

cccctcccgt acgccgccac catgatacac tcagtgtttc tactgatgtt cttgttaaca     1500

cctacagaaa gttacgttga tgtagggcca gattctgtta agtctgcttg tattgaggtt     1560

gatatacaac agactttctt tgataaaact tggcctaggc caattgatgt ttctaaggct     1620

gacggtatta tataccctca aggccgtaca tattctaaca taactatcac ttatcaaggt     1680

ctttttccct atcagggaga ccatggtgat atgtatgttt actctgcagg acatgctaca     1740

ggcacaactc cacaaaagtt gtttgtagct aactattctc aggacgtcaa acagtttgct     1800

aatgggtttg tcgtccgtat aggagcagct gccaattcca ctggcactgt tattattagc     1860

ccatctacca gcgctactat acgaaaaatt taccctgctt ttatgctggg ttcttcagtt     1920

ggtaatttct cagatggtaa aatgggccgc ttcttcaatc atactctagt tcttttgccc     1980

gatggatgtg gcactttact tagagctttt tattgtattc tagagcctcg ctctggaaat     2040

cattgtcctg ctggcaattc ctatacttct tttgccactt atcacactcc tgcaacagat     2100

tgttctgatg gcaattacaa tcgtaatgcc agtctgaact cttttaagga gtattttaat     2160

ttacgtaact gcacctttat gtacacttat aacattaccg aagatgagat tttagagtgg     2220

tttggcatta cacaaactgc tcaaggtgtt cacctcttct catctcggta tgttgatttg     2280

tacggcggca atatgtttca atttgccacc ttgcctgttt atgatactat taagtattat     2340

tctatcattc ctcacagtat tcgttctatc caaagtgata gaaaagcttg ggctgccttc     2400

tacgtatata aacttcaacc gttaactttc ctgttggatt tttctgttga tggttatata     2460

cgcagagcta tagactgtgg ttttaatgat ttgtcacaac tccactgctc atatgaatcc     2520

ttcgatgttg aatctggagt ttattcagtt tcgtctttcg aagcaaaacc ttctggctca     2580

gttgtggaac aggctgaagg tgttgaatgt gatttttcac ctcttctgtc tggcacacct     2640

cctcaggttt ataatttcaa gcgtttggtt tttaccaatt gcaattataa tcttaccaaa     2700

ttgctttcac ttttttctgt gaatgatttt acttgtagtc aaatatctcc agcagcaatt     2760

gctagcaact gttattcttc actgattttg gattactttt catacccact tagtatgaaa     2820

tccgatctca gtgttagttc tgctggtcca atatcccagt ttaattataa acagtccttt     2880

tctaatccca catgtttgat tttagcgact gttcctcata accttactac tattactaag     2940

cctcttaagt acagctatat taacaagtgc tctcgtcttc tttctgatga tcgtactgaa     3000

gtacctcagt tagtgaacgc taatcaatac tcaccctgtg tatccattgt cccatccact     3060

gtgtgggaag acggtgatta ttataggaaa caactatctc cacttgaagg tggtggctgg     3120

cttgttgcta gtggctcaac tgttgccatg actgagcaat tacagatggg ctttggtatt     3180

acagttcaat atggtacaga caccaatagt gtttgcccca agcttgaatt tgctaatgac     3240

acaaaaattg cctctcaatt aggcaattgc gtggaatatt ccctctatgg tgtttcgggc     3300

cgtggtgttt ttcagaattg cacagctgta ggtgttcgac agcagcgctt tgtttatgat     3360

gcgtaccaga atttagttgg ctattattct gatgatggca actactactg tttgcgtgct     3420

tgtgttagtg ttcctgtttc tgtcatctat gataaagaaa ctaaaaccca cgctactcta     3480

tttggtagtg ttgcatgtga acacatttct tctaccatgt ctcaatactc ccgttctacg     3540

cgatcaatgc ttaaacggcg agattctaca tatggccccc ttcagacacc tgttggttgt     3600

gtcctaggac ttgttaattc ctctttgttc gtagaggact gcaagttgcc tcttggtcaa     3660

tctctctgtg ctcttcctga cacacctagt actctcacac ctcgcagtgt gcgctctgtt     3720

ccaggtgaaa tgcgcttggc atccattgct tttaatcatc ctattcaggt tgatcaactt     3780

aatagtagtt attttaaatt aagtataccc actaattttt cctttggtgt gactcaggag     3840

tacattcaga caaccattca gaaagttact gttgattgta aacagtacgt ttgcaatggt     3900

ttccagaagt gtgagcaatt actgcgcgag tatggccagt tttgttccaa aataaaccag     3960

gctctccatg gtgccaattt acgccaggat gattctgtac gtaatttgtt tgcgagcgtg     4020

aaaagctctc aatcatctcc tatcatacca ggttttggag gtgactttaa tttgacactt     4080

ctagaacctg tttctatatc tactggcagt cgtagtgcac gtagtgctat tgaggatttg     4140

ctatttgaca aagtcactat agctgatcct ggttatatgc aaggttacga tgattgcatg     4200

cagcaaggtc cagcatcagc tcgtgatctt atttgtgctc aatatgtggc tggttacaaa     4260

gtattacctc ctcttatgga tgttaatatg gaagccgcgt atacttcatc tttgcttggc     4320

agcatagcag gtgttggctg gactgctggc ttatcctcct ttgctgctat tccatttgca     4380

cagagtatct tttataggtt aaacggtgtt ggcattactc aacaggttct ttcagagaac     4440

caaaagctta ttgccaataa gtttaatcag gctctgggag ctatgcaaac aggcttcact     4500

acaactaatg aagcttttca gaaggttcag gatgctgtga acaacaatgc acaggctcta     4560

tccaaattag ctagcgagct atctaatact tttggtgcta tttccgcctc tattggagac     4620

atcatacaac gtcttgatgt tctcgaacag gacgcccaaa tagacagact tattaatggc     4680

cgtttgacaa cactaaatgc ttttgttgca cagcagcttg ttcgttccga atcagctgct     4740

ctttccgctc aattggctaa agataaagtc aatgagtgtg tcaaggcaca atccaagcgt     4800

tctggatttt gcggtcaagg cacacatata gtgtcctttg ttgtaaatgc ccctaatggc     4860

ctttacttca tgcatgttgg ttattaccct agcaaccaca ttgaggttgt ttctgcttat     4920

ggtctttgcg atgcagctaa ccctactaat tgtatagccc ctgttaatgg ctactttatt     4980

aaaactaata acactaggat tgttgatgag tggtcatata ctggctcgtc cttctatgca     5040

cctgagccca ttacctccct taatactaag tatgttgcac cacaggtgac ataccaaaac     5100

atttctacta acctccctcc tcctcttctc ggcaattcca ccgggattga cttccaagat     5160

gagttggatg agtttttcaa aaatgttagc accagtatac ctaattttgg ttccctaaca     5220

cagattaata ctacattact cgatcttacc tacgagatgt tgtctcttca acaagttgtt     5280

aaagccctta atgagtctta catagacctt aaagagcttg gcaattatac ttattacaac     5340

aaatggccgt ggtacatttg gcttggtttc attgctgggc ttgttgcctt agctctatgc     5400

gtcttcttca tactgtgctg cactggttgt ggcacaaact gtatgggaaa acttaagtgt     5460

aattaagcta gtcatgaaaa aaactaacac ccctcctttc gaaccatccc aaacatgagc     5520

aagatctttg tcaatcctag tgctattaga gccggtctgg ccgatcttga gatggctgaa     5580

gaaactgttg atctgatcaa tagaaatatc gaagacaatc aggctcatct ccaaggggaa     5640

cccatagagg tggacaatct ccctgaggat atggggcgac ttcacctgga tgatggaaaa     5700

tcgcccaacc atggtgagat agccaaggtg ggagaaggca agtatcgaga ggactttcag     5760

atggatgaag gagaggatcc tagcttcctg ttccagtcat acctggaaaa tgttggagtc     5820

caaatagtca gacaaatgag gtcaggagag agatttctca agatatggtc acagaccgta     5880

gaagagatta tatcctatgt cgcggtcaac tttcccaacc ctccaggaaa gtcttcagag     5940

gataaatcaa cccagactac tggccgagag ctcaagaagg agacaacacc cactccttct     6000

cagagagaaa gccaatcatc gaaagccagg atggcggctc aaattgcttc tggccctcca     6060

gcccttgaat ggtcggctac caatgaagag gatgatctat cagtggaggc tgagatcgct     6120

caccagattg cagaaagttt ctccaaaaaa tataagtttc cctctcgatc ctcagggata     6180

ctcttgtata attttgagca attgaaaatg aaccttgatg atatagttaa agaggcaaaa     6240

aatgtaccag gtgtgacccg tttagcccat gacgggtcca aactccccct aagatgtgta     6300

ctgggatggg tcgctttggc caactctaag aaattccagt tgttagtcga atccgacaag     6360

ctgagtaaaa tcatgcaaga tgacttgaat cgctatacat cttgctaacc gaacctctcc     6420

cctcagtccc tctagacaat aaaatccgag atgtcccaaa gtcaacatga aaaaaacagg     6480

caacaccact gataaaatga acctcctacg taagatagtg aaaaaccgca gggacgagga     6540

cactcaaaaa tcctctcccg cgtcagcccc tctggatgac gatgacttgt ggcttccacc     6600

ccctgaatac gtcccgctga aagaacttac aggcaagaag aacatgagga acttttgtat     6660

caacggaagg gttaaagtgt gtagcccgaa tggttactcg ttcaggatcc tgcggcacat     6720

tctgaaatca ttcgacgaga tatattctgg gaatcatagg atgatcgggt tagtcaaagt     6780

ggttattgga ctggctttgt caggatctcc agtccctgag ggcctgaact gggtatacaa     6840

attgaggaga acctttatct tccagtgggc tgattccagg ggccctcttg aaggggagga     6900

gttggaatac tctcaggaga tcacttggga tgatgatact gagttcgtcg gattgcaaat     6960

aagagtgatt gcaaaacagt gtcatatcca gggcagagtc tggtgtatca acatgaaccc     7020

gagagcatgt caactatggt ctgacatgtc tcttcagaca caaaggtccg aagaggacaa     7080

agattcctct ctgcttctag aataatcaga ttatatcccg caaatttatc acttgtttac     7140

ctctggagga gagaacatat gggctcaact ccaacccttg ggagcaatat aacaaaaaac     7200

atgttatggt gccattaaac cgctgcattt catcaaagtc aagttgatta cctttacatt     7260

ttgatcctct tggatgtgaa aaaaactatt aacatccctc aaaagacccc gggaaagatg     7320

gttcctcagg ctctcctgtt tgtacccctt ctggtttttc cattgtgttt tgggaaattc     7380

cctatttaca cgataccaga caagcttggt ccctggagtc cgattgacat acatcacctc     7440

agctgcccaa acaatttggt agtggaggac gaaggatgca ccaacctgtc agggttctcc     7500

tacatggaac ttaaagttgg atacatctta gccataaaag tgaacgggtt cacttgcaca     7560

ggcgttgtga cggaggctga aacctacact aacttcgttg gttatgtcac aaccacgttc     7620

aaaagaaagc atttccgccc aacaccagat gcatgtagag ccgcgtacaa ctggaagatg     7680

gccggtgacc ccagatatga agagtctcta cacaatccgt accctgacta ccgctggctt     7740

cgaactgtaa aaaccaccaa ggagtctctc gttatcatat ctccaagtgt ggcagatttg     7800

gacccatatg acagatccct tcactcgagg gtcttcccta gcgggaagtg ctcaggagta     7860

gcggtgtctt ctacctactg ctccactaac cacgattaca ccatttggat gcccgagaat     7920

ccgagactag ggatgtcttg tgacattttt accaatagta gagggaagag agcatccaaa     7980

gggagtgaga cttgcggctt tgtagatgaa agaggcctat ataagtcttt aaaaggagca     8040

tgcaaactca agttatgtgg agttctagga cttagactta tggatggaac atgggtctcg     8100

atgcaaacat caaatgaaac caaatggtgc cctcccgata agttggtgaa cctgcacgac     8160

tttcgctcag acgaaattga gcaccttgtt gtagaggagt tggtcaggaa gagagaggag     8220

tgtctggatg cactagagtc catcatgaca accaagtcag tgagtttcag acgtctcagt     8280

catttaagaa aacttgtccc tgggtttgga aaagcatata ccatattcaa caagaccttg     8340

atggaagccg atgctcacta caagtcagtc gagacttgga atgagatcct cccttcaaaa     8400

gggtgtttaa gagttggggg gaggtgtcat cctcatgtga acggggtgtt tttcaatggt     8460

ataatattag gacctgacgg caatgtctta atcccagaga tgcaatcatc cctcctccag     8520

caacatatgg agttgttgga atcctcggtt atcccccttg tgcaccccct ggcagacccg     8580

tctaccgttt tcaaggacgg tgacgaggct gaggattttg ttgaagttca ccttcccgat     8640

gtgcacaatc aggtctcagg agttgacttg ggtctcccga actgggggaa gtatgtatta     8700

ctgagtgcag gggccctgac tgccttgatg ttgataattt tcctgatgac atgttgtaga     8760

agagtcaatc gatcagaacc tacgcaacac aatctcagag ggacagggag ggaggtgtca     8820

gtcactcccc aaagcgggaa gatcatatct tcatgggaat cacacaagag tgggggtgag     8880

accagactgt aattaattaa cgtcctttca acgatccaag tccatgaaaa aaactaacac     8940

ccctcccgta cctagcttat aaagtgctgg gtcatctaag cttttcagtc gagaaaaaaa     9000

cattagatca gaagaacaac tggcaacact tctcaacctg agacttactt caagatgctc     9060

gatcctggag aggtctatga tgaccctatt gacccaatcg agttagaggc tgaacccaga     9120

ggaaccccca ttgtccccaa catcttgagg aactctgact acaatctcaa ctctcctttg     9180

atagaagatc ctgctagact aatgttagaa tggttaaaaa cagggaatag accttatcgg     9240

atgactctaa cagacaattg ctccaggtct ttcagagttt tgaaagatta tttcaagaag     9300

gtagatttgg gttctctcaa ggtgggcgga atggctgcac agtcaatgat ttctctctgg     9360

ttatatggtg cccactctga atccaacagg agccggagat gtataacaga cttggcccat     9420

ttctattcca agtcgtcccc catagagaag ctgttgaatc tcacgctagg aaatagaggg     9480

ctgagaatcc ccccagaggg agtgttaagt tgccttgaga gggttgatta tgataatgca     9540

tttggaaggt atcttgccaa cacgtattcc tcttacttgt tcttccatgt aatcacctta     9600

tacatgaacg ccctagactg ggatgaagaa aagaccatcc tagcattatg gaaagattta     9660

acctcagtgg acatcgggaa ggacttggta aagttcaaag accaaatatg gggactgctg     9720

atcgtgacaa aggactttgt ttactcccaa agttccaatt gtctttttga cagaaactac     9780

acacttatgc taaaagatct tttcttgtct cgcttcaact ccttaatggt cttgctctct     9840

cccccagagc cccgatactc agatgacttg atatctcaac tatgccagct gtacattgct     9900

ggggatcaag tcttgtctat gtgtggaaac tccggctatg aagtcatcaa aatattggag     9960

ccatatgtcg tgaatagttt agtccagaga gcagaaaagt ttaggcctct cattcattcc    10020

ttgggagact ttcctgtatt tataaaagac aaggtaagtc aacttgaaga gacgttcggt    10080

ccctgtgcaa gaaggttctt tagggctctg gatcaattcg acaacataca tgacttggtt    10140

tttgtgtttg gctgttacag gcattggggg cacccatata tagattatcg aaagggtctg    10200

tcaaaactat atgatcaggt tcaccttaaa aaaatgatag ataagtccta ccaggagtgc    10260

ttagcaagcg acctagccag gaggatcctt agatggggtt ttgataagta ctccaagtgg    10320

tatctggatt caagattcct agcccgagac caccccttga ctccttatat caaaacccaa    10380

acatggccac ccaaacatat tgtagacttg gtgggggata catggcacaa gctcccgatc    10440

acgcagatct ttgagattcc tgaatcaatg gatccgtcag aaatattgga tgacaaatca    10500

cattctttca ccagaacgag actagcttct tggctgtcag aaaaccgagg ggggcctgtt    10560

cctagcgaaa aagttattat cacggccctg tctaagccgc ctgtcaatcc ccgagagttt    10620

ctgaggtcta tagacctcgg aggattgcca gatgaagact tgataattgg cctcaagcca    10680

aaggaacggg aattgaagat tgaaggtcga ttctttgctc taatgtcatg gaatctaaga    10740

ttgtattttg tcatcactga aaaactcttg gccaactaca tcttgccact ttttgacgcg    10800

ctgactatga cagacaacct gaacaaggtg tttaaaaagc tgatcgacag ggtcaccggg    10860

caagggcttt tggactattc aagggtcaca tatgcatttc acctggacta tgaaaagtgg    10920

aacaaccatc aaagattaga gtcaacagag gatgtatttt ctgtcctaga tcaagtgttt    10980

ggattgaaga gagtgttttc tagaacacac gagttttttc aaaaggcctg gatctattat    11040

tcagacagat cagacctcat cgggttacgg gaggatcaaa tatactgctt agatgcgtcc    11100

aacggcccaa cctgttggaa tggccaggat ggcgggctag aaggcttacg gcagaagggc    11160

tggagtctag tcagcttatt gatgatagat agagaatctc aaatcaggaa cacaagaacc    11220

aaaatactag ctcaaggaga caaccaggtt ttatgtccga catacatgtt gtcgccaggg    11280

ctatctcaag aggggctcct ctatgaattg gagagaatat caaggaatgc actttcgata    11340

tacagagccg tcgaggaagg ggcatctaag ctagggctga tcatcaagaa agaagagacc    11400

atgtgtagtt atgacttcct catctatgga aaaacccctt tgtttagagg taacatattg    11460

gtgcctgagt ccaaaagatg ggccagagtc tcttgcgtct ctaatgacca aatagtcaac    11520

ctcgccaata taatgtcgac agtgtccacc aatgcgctaa cagtggcaca acactctcaa    11580

tctttgatca aaccgatgag ggattttctg ctcatgtcag tacaggcagt ctttcactac    11640

ctgctattta gcccaatctt aaagggaaga gtttacaaga ttctgagcgc tgaaggggag    11700

agctttctcc tagccatgtc aaggataatc tatctagatc cttctttggg agggatatct    11760

ggaatgtccc tcggaagatt ccatatacga cagttctcag accctgtctc tgaagggtta    11820

tccttctgga gagagatctg gttaagctcc caagagtcct ggattcacgc gttgtgtcaa    11880

gaggctggaa acccagatct tggagagaga acactcgaga gcttcactcg ccttctagaa    11940

gatccgacca ccttaaatat cagaggaggg gccagtccta ccattctact caaggatgca    12000

atcagaaagg ctttatatga cgaggtggac aaggtggaaa attcagagtt tcgagaggca    12060

atcctgttgt ccaagaccca tagagataat tttatactct tcttaatatc tgttgagcct    12120

ctgtttcctc gatttctcag tgagctattc agttcgtctt ttttgggaat ccccgagtca    12180

atcattggat tgatacaaaa ctcccgaacg ataagaaggc agtttagaaa gagtctctca    12240

aaaactttag aagaatcctt ctacaactca gagatccacg ggattagtcg gatgacccag    12300

acacctcaga gggttggggg ggtgtggcct tgctcttcag agagggcaga tctacttagg    12360

gagatctctt ggggaagaaa agtggtaggc acgacagttc ctcacccttc tgagatgttg    12420

ggattacttc ccaagtcctc tatttcttgc acttgtggag caacaggagg aggcaatcct    12480

agagtttctg tatcagtact cccgtccttt gatcagtcat ttttttcacg aggcccccta    12540

aagggatact tgggctcgtc cacctctatg tcgacccagc tattccatgc atgggaaaaa    12600

gtcactaatg ttcatgtggt gaagagagct ctatcgttaa aagaatctat aaactggttc    12660

attactagag attccaactt ggctcaagct ctaattagga acattatgtc tctgacaggc    12720

cctgatttcc ctctagagga ggcccctgtc ttcaaaagga cggggtcagc cttgcatagg    12780

ttcaagtctg ccagatacag cgaaggaggg tattcttctg tctgcccgaa cctcctctct    12840

catatttctg ttagtacaga caccatgtct gatttgaccc aagacgggaa gaactacgat    12900

ttcatgttcc agccattgat gctttatgca cagacatgga catcagagct ggtacagaga    12960

gacacaaggc taagagactc tacgtttcat tggcacctcc gatgcaacag gtgtgtgaga    13020

cccattgacg acgtgaccct ggagacctct cagatcttcg agtttccgga tgtgtcgaaa    13080

agaatatcca gaatggtttc tggggctgtg cctcacttcc agaggcttcc cgatatccgt    13140

ctgagaccag gagattttga atctctaagc ggtagagaaa agtctcacca tatcggatca    13200

gctcaggggc tcttatactc aatcttagtg gcaattcacg actcaggata caatgatgga    13260

accatcttcc ctgtcaacat atacggcaag gtttccccta gagactattt gagagggctc    13320

gcaaggggag tattgatagg atcctcgatt tgcttcttga caagaatgac aaatatcaat    13380

attaatagac ctcttgaatt ggtctcaggg gtaatctcat atattctcct gaggctagat    13440

aaccatccct ccttgtacat aatgctcaga gaaccgtctc ttagaggaga gatattttct    13500

atccctcaga aaatccccgc cgcttatcca accactatga aagaaggcaa cagatcaatc    13560

ttgtgttatc tccaacatgt gctacgctat gagcgagaga taatcacggc gtctccagag    13620

aatgactggc tatggatctt ttcagacttt agaagtgcca aaatgacgta cctatccctc    13680

attacttacc agtctcatct tctactccag agggttgaga gaaacctatc taagagtatg    13740

agagataacc tgcgacaatt gagttctttg atgaggcagg tgctgggcgg gcacggagaa    13800

gataccttag agtcagacga caacattcaa cgactgctaa aagactcttt acgaaggaca    13860

agatgggtgg atcaagaggt gcgccatgca gctagaacca tgactggaga ttacagcccc    13920

aacaagaagg tgtcccgtaa ggtaggatgt tcagaatggg tctgctctgc tcaacaggtt    13980

gcagtctcta cctcagcaaa cccggcccct gtctcggagc ttgacataag ggccctctct    14040

aagaggttcc agaacccttt gatctcgggc ttgagagtgg ttcagtgggc aaccggtgct    14100

cattataagc ttaagcctat tctagatgat ctcaatgttt tcccatctct ctgccttgta    14160

gttggggacg ggtcaggggg gatatcaagg gcagtcctca acatgtttcc agatgccaag    14220

cttgtgttca acagtctttt agaggtgaat gacctgatgg cttccggaac acatccactg    14280

cctccttcag caatcatgag gggaggaaat gatatcgtct ccagagtgat agatcttgac    14340

tcaatctggg aaaaaccgtc cgacttgaga aacttggcaa cctggaaata cttccagtca    14400

gtccaaaagc aggtcaacat gtcctatgac ctcattattt gcgatgcaga agttactgac    14460

attgcatcta tcaaccggat caccctgtta atgtccgatt ttgcattgtc tatagatgga    14520

ccactctatt tggtcttcaa aacttatggg actatgctag taaatccaaa ctacaaggct    14580

attcaacacc tgtcaagagc gttcccctcg gtcacagggt ttatcaccca agtaacttcg    14640

tctttttcat ctgagctcta cctccgattc tccaaacgag ggaagttttt cagagatgct    14700

gagtacttga cctcttccac ccttcgagaa atgagccttg tgttattcaa ttgtagcagc    14760

cccaagagtg agatgcagag agctcgttcc ttgaactatc aggatcttgt gagaggattt    14820

cctgaagaaa tcatatcaaa tccttacaat gagatgatca taactctgat tgacagtgat    14880

gtagaatctt ttctagtcca caagatggtt gatgatcttg agttacagag gggaactctg    14940

tctaaagtgg ctatcattat agccatcatg atagttttct ccaacagagt cttcaacgtt    15000

tccaaacccc taactgaccc ctcgttctat ccaccgtctg atcccaaaat cctgaggcac    15060

ttcaacatat gttgcagtac tatgatgtat ctatctactg ctttaggtga cgtccctagc    15120

ttcgcaagac ttcacgacct gtataacaga cctataactt attacttcag aaagcaagtc    15180

attcgaggga acgtttatct atcttggagt tggtccaacg acacctcagt gttcaaaagg    15240

gtagcctgta attctagcct gagtctgtca tctcactgga tcaggttgat ttacaagata    15300

gtgaagacta ccagactcgt tggcagcatc aaggatctat ccagagaagt ggaaagacac    15360

cttcataggt acaacaggtg gatcacccta gaggatatca gatctagatc atccctacta    15420

gactacagtt gcctgtgaac cggatactcc tggaagcctg cccatgctaa gactcttgtg    15480

tgatgtatct tgaaaaaaac aagatcctaa atctgaacct ttggttgttt gattgttttt    15540

ctcatttttg ttgtttattt gttaagcgt                                      15569


