                         SEQUENCE LISTING

<110>  PROMAB BIOTECHNOLOGIES, INC.
       FOREVERTEK BIOTECHNOLOGY CO., LTD.
       WU, Lijun
       GOLUBOVSKAYA, Vita
       ZHOU, Hua
 
<120>  CAR HAVING REPLICATED BINDING MOTIFS IN A COSTIMULATORY DOMAIN

<130>  119996-8001.WO01

<150>  US 62/317,975
<151>  2016-04-04

<160>  33    

<170>  PatentIn version 3.5

<210>  1
<211>  8
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  1
dykddddk                                                                 8


<210>  2
<211>  4
<212>  PRT
<213>  Homo sapiens

<400>  2

Tyr Met Asn Met 
1               


<210>  3
<211>  4
<212>  PRT
<213>  Homo sapiens

<400>  3

Pro Tyr Ala Pro 
1               


<210>  4
<211>  4
<212>  PRT
<213>  Homo sapiens

<400>  4

Gln Glu Glu Asp 
1               


<210>  5
<211>  4
<212>  PRT
<213>  Homo sapiens

<400>  5

Glu Glu Glu Glu 
1               


<210>  6
<211>  4
<212>  PRT
<213>  Homo sapiens

<400>  6

Tyr Met Phe Met 
1               


<210>  7
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  7

Thr Pro Ile Gln Glu Glu Gln Ala Asp 
1               5                   


<210>  8
<211>  4
<212>  PRT
<213>  Homo sapiens

<400>  8

Tyr Ile Asn Met 
1               


<210>  9
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  9

Pro Ile Gln Glu Asp 
1               5   


<210>  10
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  10

Ser Cys Gln Phe Pro Glu Glu Glu Arg Gly Glu 
1               5                   10      


<210>  11
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro 
            20      


<210>  12
<211>  127
<212>  PRT
<213>  Homo sapiens

<400>  12

Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Thr Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser Val Ser Ser Asn 
            20                  25                  30          


Ser Ala Thr Trp Asn Trp Ile Arg Gln Ser Pro Ser Arg Gly Leu Glu 
        35                  40                  45              


Trp Leu Gly Arg Thr Tyr Tyr Arg Ser Lys Trp Tyr Asn Asp Tyr Ala 
    50                  55                  60                  


Val Ser Val Lys Ser Arg Met Glu Thr Ser Ile Asn Pro Asp Thr Ser 
65                  70                  75                  80  


Lys Asn Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Pro Glu Asp Thr 
                85                  90                  95      


Ala Val Tyr Tyr Cys Ala Arg Gly Met Met Thr Tyr Tyr Tyr Gly Met 
            100                 105                 110         


Glu Thr Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125         


<210>  13
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  13

Gly Ile Leu Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210>  14
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  14

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  15
<211>  116
<212>  PRT
<213>  Homo sapiens

<400>  15

Gln Pro Val Leu Thr Gln Ser Ser Ser Leu Ser Ala Ser Pro Gly Ala 
1               5                   10                  15      


Ser Ala Ser Leu Thr Cys Thr Leu Arg Ser Gly Ile Asn Val Gly Pro 
            20                  25                  30          


Tyr Arg Ile Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Pro Pro Gln Tyr 
        35                  40                  45              


Leu Leu Asn Tyr Lys Ser Asp Ser Asp Lys Gln Gln Gly Ser Gly Val 
    50                  55                  60                  


Pro Ser Arg Phe Ser Gly Ser Lys Asp Ala Ser Ala Asn Ala Gly Val 
65                  70                  75                  80  


Leu Leu Ile Ser Gly Leu Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys 
                85                  90                  95      


Met Ile Trp His Ser Ser Ala Ala Val Phe Gly Gly Gly Thr Gln Leu 
            100                 105                 110         


Thr Val Leu Ser 
        115     


<210>  16
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  16

Asp Tyr Lys Asp Asp Asp Asp Lys 
1               5               


<210>  17
<211>  49
<212>  PRT
<213>  Homo sapiens

<400>  17

Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
1               5                   10                  15      


Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Ser Arg Pro Ala 
            20                  25                  30          


Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Ser Asp Lys 
        35                  40                  45              


Pro 
    


<210>  18
<211>  49
<212>  PRT
<213>  Homo sapiens

<400>  18

Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
1               5                   10                  15      


Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala 
            20                  25                  30          


Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Lys 
        35                  40                  45              


Pro 
    


<210>  19
<211>  220
<212>  PRT
<213>  Homo sapiens

<400>  19

Met Leu Arg Leu Leu Leu Ala Leu Asn Leu Phe Pro Ser Ile Gln Val 
1               5                   10                  15      


Thr Gly Asn Lys Ile Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr 
            20                  25                  30          


Asp Asn Ala Val Asn Leu Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser 
        35                  40                  45              


Arg Glu Phe Arg Ala Ser Leu His Lys Gly Leu Asp Ser Ala Val Glu 
    50                  55                  60                  


Val Cys Val Val Tyr Gly Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser 
65                  70                  75                  80  


Lys Thr Gly Phe Asn Cys Asp Gly Lys Leu Gly Asn Glu Ser Val Thr 
                85                  90                  95      


Phe Tyr Leu Gln Asn Leu Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys 
            100                 105                 110         


Lys Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser 
        115                 120                 125             


Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro 
    130                 135                 140                 


Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly 
145                 150                 155                 160 


Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile 
                165                 170                 175     


Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met 
            180                 185                 190         


Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro 
        195                 200                 205             


Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
    210                 215                 220 


<210>  20
<211>  27
<212>  PRT
<213>  Homo sapiens

<400>  20

Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
1               5                   10                  15      


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val 
            20                  25          


<210>  21
<211>  41
<212>  PRT
<213>  Homo sapiens

<400>  21

Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
1               5                   10                  15      


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            20                  25                  30          


Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        35                  40      


<210>  22
<211>  76
<212>  PRT
<213>  Homo sapiens

<400>  22

Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
1               5                   10                  15      


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser 
            20                  25                  30          


Arg Leu Leu His Ser Asp Tyr Met Asn Met Tyr Met Asn Met Thr Pro 
        35                  40                  45              


Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro 
    50                  55                  60                  


Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
65                  70                  75      


<210>  23
<211>  76
<212>  PRT
<213>  Homo sapiens

<400>  23

Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
1               5                   10                  15      


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser 
            20                  25                  30          


Arg Leu Leu His Ser Asp Tyr Met Asn Met Tyr Met Asn Met Pro Pro 
        35                  40                  45              


Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro 
    50                  55                  60                  


Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
65                  70                  75      


<210>  24
<211>  115
<212>  PRT
<213>  Homo sapiens

<400>  24

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Glu Thr Gly 
        35                  40                  45              


Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
    50                  55                  60                  


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
65                  70                  75                  80  


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
                85                  90                  95      


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
            100                 105                 110         


Pro Pro Arg 
        115 


<210>  25
<211>  130
<212>  PRT
<213>  Homo sapiens

<400>  25

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Glu Thr Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln 
    50                  55                  60                  


Lys Phe Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr 
65                  70                  75                  80  


Ala Tyr Met Glu Thr Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala 
                85                  90                  95      


Val Tyr Tyr Cys Ala Arg Glu Glu Gly Pro Tyr Cys Ser Ser Thr Ser 
            100                 105                 110         


Cys Tyr Gly Ala Phe Asp Ile Trp Gly Gln Gly Thr Leu Val Thr Val 
        115                 120                 125             


Ser Ser 
    130 


<210>  26
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  26

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  27
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  27

Gln Ser Val Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      


Thr Val Lys Ile Thr Cys Gln Gly Asp Ser Leu Arg Ser Tyr Phe Ala 
            20                  25                  30          


Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Thr Leu Val Met Glu 
        35                  40                  45              


Thr Tyr Ala Arg Asn Asp Arg Pro Ala Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Asn Gly Tyr Leu Phe Gly Ala Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  28
<211>  529
<212>  PRT
<213>  Homo sapiens

<400>  28

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Ala Ser Gln Val Gln Leu Gln Gln Ser Gly Pro 
            20                  25                  30          


Gly Leu Val Thr Pro Ser Gln Thr Leu Ser Leu Thr Cys Ala Ile Ser 
        35                  40                  45              


Gly Asp Ser Val Ser Ser Asn Ser Ala Thr Trp Asn Trp Ile Arg Gln 
    50                  55                  60                  


Ser Pro Ser Arg Gly Leu Glu Trp Leu Gly Arg Thr Tyr Tyr Arg Ser 
65                  70                  75                  80  


Lys Trp Tyr Asn Asp Tyr Ala Val Ser Val Lys Ser Arg Met Ser Ile 
                85                  90                  95      


Asn Pro Asp Thr Ser Lys Asn Gln Phe Ser Leu Gln Leu Asn Ser Val 
            100                 105                 110         


Thr Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Met Met Thr 
        115                 120                 125             


Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val 
    130                 135                 140                 


Ser Ser Gly Ile Leu Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
145                 150                 155                 160 


Ser Gly Gly Gly Gly Ser Gln Pro Val Leu Thr Gln Ser Ser Ser Leu 
                165                 170                 175     


Ser Ala Ser Pro Gly Ala Ser Ala Ser Leu Thr Cys Thr Leu Arg Ser 
            180                 185                 190         


Gly Ile Asn Val Gly Pro Tyr Arg Ile Tyr Trp Tyr Gln Gln Lys Pro 
        195                 200                 205             


Gly Ser Pro Pro Gln Tyr Leu Leu Asn Tyr Lys Ser Asp Ser Asp Lys 
    210                 215                 220                 


Gln Gln Gly Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Lys Asp Ala 
225                 230                 235                 240 


Ser Ala Asn Ala Gly Val Leu Leu Ile Ser Gly Leu Arg Ser Glu Asp 
                245                 250                 255     


Glu Ala Asp Tyr Tyr Cys Met Ile Trp His Ser Ser Ala Ala Val Phe 
            260                 265                 270         


Gly Gly Gly Thr Gln Leu Thr Val Leu Ser Leu Glu Asp Tyr Lys Asp 
        275                 280                 285             


Asp Asp Asp Lys Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr 
    290                 295                 300                 


Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala 
305                 310                 315                 320 


Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe 
                325                 330                 335     


Ala Cys Asp Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu 
            340                 345                 350         


Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val 
        355                 360                 365             


Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Tyr 
    370                 375                 380                 


Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln 
385                 390                 395                 400 


Pro Tyr Ala Pro Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg 
                405                 410                 415     


Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln 
            420                 425                 430         


Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
        435                 440                 445             


Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
    450                 455                 460                 


Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
465                 470                 475                 480 


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
                485                 490                 495     


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
            500                 505                 510         


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
        515                 520                 525             


Arg 
    


<210>  29
<211>  529
<212>  PRT
<213>  Homo sapiens

<400>  29

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Ala Ser Gln Val Gln Leu Gln Gln Ser Gly Pro 
            20                  25                  30          


Gly Leu Val Thr Pro Ser Gln Thr Leu Ser Leu Thr Cys Ala Ile Ser 
        35                  40                  45              


Gly Asp Ser Val Ser Ser Asn Ser Ala Thr Trp Asn Trp Ile Arg Gln 
    50                  55                  60                  


Ser Pro Ser Arg Gly Leu Glu Trp Leu Gly Arg Thr Tyr Tyr Arg Ser 
65                  70                  75                  80  


Lys Trp Tyr Asn Asp Tyr Ala Val Ser Val Lys Ser Arg Met Ser Ile 
                85                  90                  95      


Asn Pro Asp Thr Ser Lys Asn Gln Phe Ser Leu Gln Leu Asn Ser Val 
            100                 105                 110         


Thr Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Met Met Thr 
        115                 120                 125             


Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val 
    130                 135                 140                 


Ser Ser Gly Ile Leu Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
145                 150                 155                 160 


Ser Gly Gly Gly Gly Ser Gln Pro Val Leu Thr Gln Ser Ser Ser Leu 
                165                 170                 175     


Ser Ala Ser Pro Gly Ala Ser Ala Ser Leu Thr Cys Thr Leu Arg Ser 
            180                 185                 190         


Gly Ile Asn Val Gly Pro Tyr Arg Ile Tyr Trp Tyr Gln Gln Lys Pro 
        195                 200                 205             


Gly Ser Pro Pro Gln Tyr Leu Leu Asn Tyr Lys Ser Asp Ser Asp Lys 
    210                 215                 220                 


Gln Gln Gly Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Lys Asp Ala 
225                 230                 235                 240 


Ser Ala Asn Ala Gly Val Leu Leu Ile Ser Gly Leu Arg Ser Glu Asp 
                245                 250                 255     


Glu Ala Asp Tyr Tyr Cys Met Ile Trp His Ser Ser Ala Ala Val Phe 
            260                 265                 270         


Gly Gly Gly Thr Gln Leu Thr Val Leu Ser Leu Glu Asp Tyr Lys Asp 
        275                 280                 285             


Asp Asp Asp Lys Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr 
    290                 295                 300                 


Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala 
305                 310                 315                 320 


Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe 
                325                 330                 335     


Ala Cys Asp Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu 
            340                 345                 350         


Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val 
        355                 360                 365             


Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Tyr 
    370                 375                 380                 


Met Asn Met Pro Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln 
385                 390                 395                 400 


Pro Tyr Ala Pro Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg 
                405                 410                 415     


Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln 
            420                 425                 430         


Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
        435                 440                 445             


Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
    450                 455                 460                 


Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
465                 470                 475                 480 


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
                485                 490                 495     


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
            500                 505                 510         


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
        515                 520                 525             


Arg 
    


<210>  30
<211>  517
<212>  PRT
<213>  Homo sapiens

<400>  30

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Ala Ser Glu Val Gln Leu Val Gln Ser Gly Ala 
            20                  25                  30          


Glu Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser 
        35                  40                  45              


Gly Gly Thr Phe Ser Ser Tyr Ala Ile Ser Trp Val Arg Gln Ala Pro 
    50                  55                  60                  


Gly Gln Gly Leu Glu Trp Met Glu Thr Gly Gly Ile Ile Pro Ile Phe 
65                  70                  75                  80  


Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Ile Thr 
                85                  90                  95      


Ala Asp Glu Ser Thr Ser Thr Ala Tyr Met Glu Thr Glu Leu Ser Ser 
            100                 105                 110         


Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Glu Glu Gly 
        115                 120                 125             


Pro Tyr Cys Ser Ser Thr Ser Cys Tyr Gly Ala Phe Asp Ile Trp Gly 
    130                 135                 140                 


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Val Leu Thr Gln Asp Pro 
                165                 170                 175     


Ala Val Ser Val Ala Leu Gly Gln Thr Val Lys Ile Thr Cys Gln Gly 
            180                 185                 190         


Asp Ser Leu Arg Ser Tyr Phe Ala Ser Trp Tyr Gln Gln Lys Pro Gly 
        195                 200                 205             


Gln Ala Pro Thr Leu Val Met Glu Thr Tyr Ala Arg Asn Asp Arg Pro 
    210                 215                 220                 


Ala Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala 
225                 230                 235                 240 


Ser Leu Ala Ile Ser Gly Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr 
                245                 250                 255     


Cys Ala Ala Trp Asp Asp Ser Leu Asn Gly Tyr Leu Phe Gly Ala Gly 
            260                 265                 270         


Thr Lys Leu Thr Val Leu Leu Glu Lys Pro Thr Thr Thr Pro Ala Pro 
        275                 280                 285             


Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu 
    290                 295                 300                 


Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg 
305                 310                 315                 320 


Gly Leu Asp Phe Ala Cys Asp Lys Pro Phe Trp Val Leu Val Val Val 
                325                 330                 335     


Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile 
            340                 345                 350         


Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr 
        355                 360                 365             


Met Asn Met Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg 
    370                 375                 380                 


Lys His Tyr Gln Pro Tyr Ala Pro Pro Tyr Ala Pro Pro Arg Asp Phe 
385                 390                 395                 400 


Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro 
                405                 410                 415     


Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly 
            420                 425                 430         


Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro 
        435                 440                 445             


Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr 
    450                 455                 460                 


Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly 
465                 470                 475                 480 


Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln 
                485                 490                 495     


Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln 
            500                 505                 510         


Ala Leu Pro Pro Arg 
        515         


<210>  31
<211>  517
<212>  PRT
<213>  Homo sapiens

<400>  31

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Ala Ser Glu Val Gln Leu Val Gln Ser Gly Ala 
            20                  25                  30          


Glu Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser 
        35                  40                  45              


Gly Gly Thr Phe Ser Ser Tyr Ala Ile Ser Trp Val Arg Gln Ala Pro 
    50                  55                  60                  


Gly Gln Gly Leu Glu Trp Met Glu Thr Gly Gly Ile Ile Pro Ile Phe 
65                  70                  75                  80  


Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Ile Thr 
                85                  90                  95      


Ala Asp Glu Ser Thr Ser Thr Ala Tyr Met Glu Thr Glu Leu Ser Ser 
            100                 105                 110         


Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Glu Glu Gly 
        115                 120                 125             


Pro Tyr Cys Ser Ser Thr Ser Cys Tyr Gly Ala Phe Asp Ile Trp Gly 
    130                 135                 140                 


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Val Leu Thr Gln Asp Pro 
                165                 170                 175     


Ala Val Ser Val Ala Leu Gly Gln Thr Val Lys Ile Thr Cys Gln Gly 
            180                 185                 190         


Asp Ser Leu Arg Ser Tyr Phe Ala Ser Trp Tyr Gln Gln Lys Pro Gly 
        195                 200                 205             


Gln Ala Pro Thr Leu Val Met Glu Thr Tyr Ala Arg Asn Asp Arg Pro 
    210                 215                 220                 


Ala Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala 
225                 230                 235                 240 


Ser Leu Ala Ile Ser Gly Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr 
                245                 250                 255     


Cys Ala Ala Trp Asp Asp Ser Leu Asn Gly Tyr Leu Phe Gly Ala Gly 
            260                 265                 270         


Thr Lys Leu Thr Val Leu Leu Glu Lys Pro Thr Thr Thr Pro Ala Pro 
        275                 280                 285             


Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu 
    290                 295                 300                 


Arg Pro Glu Ala Ser Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg 
305                 310                 315                 320 


Gly Leu Asp Phe Ala Ser Asp Lys Pro Phe Trp Val Leu Val Val Val 
                325                 330                 335     


Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile 
            340                 345                 350         


Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr 
        355                 360                 365             


Met Asn Met Tyr Met Asn Met Pro Pro Arg Arg Pro Gly Pro Thr Arg 
    370                 375                 380                 


Lys His Tyr Gln Pro Tyr Ala Pro Pro Tyr Ala Pro Pro Arg Asp Phe 
385                 390                 395                 400 


Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro 
                405                 410                 415     


Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly 
            420                 425                 430         


Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro 
        435                 440                 445             


Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr 
    450                 455                 460                 


Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly 
465                 470                 475                 480 


Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln 
                485                 490                 495     


Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln 
            500                 505                 510         


Ala Leu Pro Pro Arg 
        515         


<210>  32
<211>  521
<212>  PRT
<213>  Homo sapiens

<400>  32

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Ala Ser Gln Val Gln Leu Gln Gln Ser Gly Pro 
            20                  25                  30          


Gly Leu Val Thr Pro Ser Gln Thr Leu Ser Leu Thr Cys Ala Ile Ser 
        35                  40                  45              


Gly Asp Ser Val Ser Ser Asn Ser Ala Thr Trp Asn Trp Ile Arg Gln 
    50                  55                  60                  


Ser Pro Ser Arg Gly Leu Glu Trp Leu Gly Arg Thr Tyr Tyr Arg Ser 
65                  70                  75                  80  


Lys Trp Tyr Asn Asp Tyr Ala Val Ser Val Lys Ser Arg Met Ser Ile 
                85                  90                  95      


Asn Pro Asp Thr Ser Lys Asn Gln Phe Ser Leu Gln Leu Asn Ser Val 
            100                 105                 110         


Thr Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Met Met Thr 
        115                 120                 125             


Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val 
    130                 135                 140                 


Ser Ser Gly Ile Leu Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
145                 150                 155                 160 


Ser Gly Gly Gly Gly Ser Gln Pro Val Leu Thr Gln Ser Ser Ser Leu 
                165                 170                 175     


Ser Ala Ser Pro Gly Ala Ser Ala Ser Leu Thr Cys Thr Leu Arg Ser 
            180                 185                 190         


Gly Ile Asn Val Gly Pro Tyr Arg Ile Tyr Trp Tyr Gln Gln Lys Pro 
        195                 200                 205             


Gly Ser Pro Pro Gln Tyr Leu Leu Asn Tyr Lys Ser Asp Ser Asp Lys 
    210                 215                 220                 


Gln Gln Gly Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Lys Asp Ala 
225                 230                 235                 240 


Ser Ala Asn Ala Gly Val Leu Leu Ile Ser Gly Leu Arg Ser Glu Asp 
                245                 250                 255     


Glu Ala Asp Tyr Tyr Cys Met Ile Trp His Ser Ser Ala Ala Val Phe 
            260                 265                 270         


Gly Gly Gly Thr Gln Leu Thr Val Leu Ser Leu Glu Lys Pro Thr Thr 
        275                 280                 285             


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
    290                 295                 300                 


Pro Leu Ser Leu Arg Pro Glu Ala Ser Arg Pro Ala Ala Gly Gly Ala 
305                 310                 315                 320 


Val His Thr Arg Gly Leu Asp Phe Ala Ser Asp Lys Pro Phe Trp Val 
                325                 330                 335     


Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr 
            340                 345                 350         


Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu 
        355                 360                 365             


His Ser Asp Tyr Met Asn Met Tyr Met Asn Met Thr Pro Arg Arg Pro 
    370                 375                 380                 


Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Tyr Ala Pro 
385                 390                 395                 400 


Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser 
                405                 410                 415     


Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
            420                 425                 430         


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
        435                 440                 445             


Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln 
    450                 455                 460                 


Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
465                 470                 475                 480 


Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
                485                 490                 495     


Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
            500                 505                 510         


Leu His Met Gln Ala Leu Pro Pro Arg 
        515                 520     


<210>  33
<211>  521
<212>  PRT
<213>  Homo sapiens

<400>  33

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Ala Ser Gln Val Gln Leu Gln Gln Ser Gly Pro 
            20                  25                  30          


Gly Leu Val Thr Pro Ser Gln Thr Leu Ser Leu Thr Cys Ala Ile Ser 
        35                  40                  45              


Gly Asp Ser Val Ser Ser Asn Ser Ala Thr Trp Asn Trp Ile Arg Gln 
    50                  55                  60                  


Ser Pro Ser Arg Gly Leu Glu Trp Leu Gly Arg Thr Tyr Tyr Arg Ser 
65                  70                  75                  80  


Lys Trp Tyr Asn Asp Tyr Ala Val Ser Val Lys Ser Arg Met Ser Ile 
                85                  90                  95      


Asn Pro Asp Thr Ser Lys Asn Gln Phe Ser Leu Gln Leu Asn Ser Val 
            100                 105                 110         


Thr Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Met Met Thr 
        115                 120                 125             


Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val 
    130                 135                 140                 


Ser Ser Gly Ile Leu Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
145                 150                 155                 160 


Ser Gly Gly Gly Gly Ser Gln Pro Val Leu Thr Gln Ser Ser Ser Leu 
                165                 170                 175     


Ser Ala Ser Pro Gly Ala Ser Ala Ser Leu Thr Cys Thr Leu Arg Ser 
            180                 185                 190         


Gly Ile Asn Val Gly Pro Tyr Arg Ile Tyr Trp Tyr Gln Gln Lys Pro 
        195                 200                 205             


Gly Ser Pro Pro Gln Tyr Leu Leu Asn Tyr Lys Ser Asp Ser Asp Lys 
    210                 215                 220                 


Gln Gln Gly Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Lys Asp Ala 
225                 230                 235                 240 


Ser Ala Asn Ala Gly Val Leu Leu Ile Ser Gly Leu Arg Ser Glu Asp 
                245                 250                 255     


Glu Ala Asp Tyr Tyr Cys Met Ile Trp His Ser Ser Ala Ala Val Phe 
            260                 265                 270         


Gly Gly Gly Thr Gln Leu Thr Val Leu Ser Leu Glu Lys Pro Thr Thr 
        275                 280                 285             


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
    290                 295                 300                 


Pro Leu Ser Leu Arg Pro Glu Ala Ser Arg Pro Ala Ala Gly Gly Ala 
305                 310                 315                 320 


Val His Thr Arg Gly Leu Asp Phe Ala Ser Asp Lys Pro Phe Trp Val 
                325                 330                 335     


Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr 
            340                 345                 350         


Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu 
        355                 360                 365             


His Ser Asp Tyr Met Asn Met Tyr Met Asn Met Pro Pro Arg Arg Pro 
    370                 375                 380                 


Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Tyr Ala Pro 
385                 390                 395                 400 


Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser 
                405                 410                 415     


Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
            420                 425                 430         


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
        435                 440                 445             


Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln 
    450                 455                 460                 


Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
465                 470                 475                 480 


Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
                485                 490                 495     


Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
            500                 505                 510         


Leu His Met Gln Ala Leu Pro Pro Arg 
        515                 520     


