                         SEQUENCE LISTING

<110>  Immunocore Limited
 
<120>  T Cell Receptors

<130>  P101450WO

<150>  1606009.7
<151>  2016-04-08

<160>  81    

<170>  PatentIn version 3.5

<210>  1
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  1

Gly Val Tyr Asp Gly Arg Glu His Thr Val 
1               5                   10  


<210>  2
<211>  207
<212>  PRT
<213>  Homo sapiens

<400>  2

Lys Asn Gln Val Glu Gln Ser Pro Gln Ser Leu Ile Ile Leu Glu Gly 
1               5                   10                  15      


Lys Asn Cys Thr Leu Gln Cys Asn Tyr Thr Val Ser Pro Phe Ser Asn 
            20                  25                  30          


Leu Arg Trp Tyr Lys Gln Asp Thr Gly Arg Gly Pro Val Ser Leu Thr 
        35                  40                  45              


Ile Met Thr Phe Ser Glu Asn Thr Lys Ser Asn Gly Arg Tyr Thr Ala 
    50                  55                  60                  


Thr Leu Asp Ala Asp Thr Lys Gln Ser Ser Leu His Ile Thr Ala Ser 
65                  70                  75                  80  


Gln Leu Ser Asp Ser Ala Ser Tyr Ile Cys Val Val Asn His Ser Gly 
                85                  90                  95      


Gly Ser Tyr Ile Pro Thr Phe Gly Arg Gly Thr Ser Leu Ile Val His 
            100                 105                 110         


Pro Tyr Ile Gln Lys Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser 
        115                 120                 125             


Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Gln 
    130                 135                 140                 


Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys 
145                 150                 155                 160 


Thr Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala Val 
                165                 170                 175     


Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn 
            180                 185                 190         


Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser 
        195                 200                 205         


<210>  3
<211>  246
<212>  PRT
<213>  Homo sapiens

<400>  3

Asp Val Lys Val Thr Gln Ser Ser Arg Tyr Leu Val Lys Arg Thr Gly 
1               5                   10                  15      


Glu Lys Val Phe Leu Glu Cys Val Gln Asp Met Asp His Glu Asn Met 
            20                  25                  30          


Phe Trp Tyr Arg Gln Asp Pro Gly Leu Gly Leu Arg Leu Ile Tyr Phe 
        35                  40                  45              


Ser Tyr Asp Val Lys Met Lys Glu Lys Gly Asp Ile Pro Glu Gly Tyr 
    50                  55                  60                  


Ser Val Ser Arg Glu Lys Lys Glu Arg Phe Ser Leu Ile Leu Glu Ser 
65                  70                  75                  80  


Ala Ser Thr Asn Gln Thr Ser Met Tyr Leu Cys Ala Ser Ser Phe Leu 
                85                  90                  95      


Met Thr Ser Gly Asp Pro Tyr Glu Gln Tyr Phe Gly Pro Gly Thr Arg 
            100                 105                 110         


Leu Thr Val Thr Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala 
        115                 120                 125             


Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr 
    130                 135                 140                 


Leu Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser 
145                 150                 155                 160 


Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro 
                165                 170                 175     


Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu 
            180                 185                 190         


Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn 
        195                 200                 205             


His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu 
    210                 215                 220                 


Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu 
225                 230                 235                 240 


Ala Trp Gly Arg Ala Asp 
                245     


<210>  4
<211>  207
<212>  PRT
<213>  Homo sapiens

<400>  4

Lys Asn Gln Val Glu Gln Ser Pro Gln Ser Leu Ile Ile Leu Glu Gly 
1               5                   10                  15      


Lys Asn Cys Thr Leu Gln Cys Asn Tyr Thr Val Ser Pro Phe Ser Asn 
            20                  25                  30          


Leu Arg Trp Tyr Lys Gln Asp Thr Gly Arg Gly Pro Val Ser Leu Thr 
        35                  40                  45              


Ile Met Thr Phe Ser Glu Asn Thr Lys Ser Asn Gly Arg Tyr Thr Ala 
    50                  55                  60                  


Thr Leu Asp Ala Asp Thr Lys Gln Ser Ser Leu His Ile Thr Ala Ser 
65                  70                  75                  80  


Gln Leu Ser Asp Ser Ala Ser Tyr Ile Cys Val Val Asn His Ser Gly 
                85                  90                  95      


Gly Ser Tyr Ile Pro Thr Phe Gly Arg Gly Thr Ser Leu Ile Val His 
            100                 105                 110         


Pro Tyr Ile Gln Lys Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser 
        115                 120                 125             


Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Gln 
    130                 135                 140                 


Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys 
145                 150                 155                 160 


Cys Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala Val 
                165                 170                 175     


Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn 
            180                 185                 190         


Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser 
        195                 200                 205         


<210>  5
<211>  246
<212>  PRT
<213>  Homo sapiens

<400>  5

Asp Val Lys Val Thr Gln Ser Ser Arg Tyr Leu Val Lys Arg Thr Gly 
1               5                   10                  15      


Glu Lys Val Phe Leu Glu Cys Val Gln Asp Met Asp His Glu Asn Met 
            20                  25                  30          


Phe Trp Tyr Arg Gln Asp Pro Gly Leu Gly Leu Arg Leu Ile Tyr Phe 
        35                  40                  45              


Ser Tyr Asp Val Lys Met Lys Glu Lys Gly Asp Ile Pro Glu Gly Tyr 
    50                  55                  60                  


Ser Val Ser Arg Glu Lys Lys Glu Arg Phe Ser Leu Ile Leu Glu Ser 
65                  70                  75                  80  


Ala Ser Thr Asn Gln Thr Ser Met Tyr Leu Cys Ala Ser Ser Phe Leu 
                85                  90                  95      


Met Thr Ser Gly Asp Pro Tyr Glu Gln Tyr Phe Gly Pro Gly Thr Arg 
            100                 105                 110         


Leu Thr Val Thr Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala 
        115                 120                 125             


Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr 
    130                 135                 140                 


Leu Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser 
145                 150                 155                 160 


Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro 
                165                 170                 175     


Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Ala Leu 
            180                 185                 190         


Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asp Pro Arg Asn 
        195                 200                 205             


His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu 
    210                 215                 220                 


Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu 
225                 230                 235                 240 


Ala Trp Gly Arg Ala Asp 
                245     


<210>  6
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  6

Val Ser Pro Phe Ser Asn 
1               5       


<210>  7
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Thr Phe Ser Glu Asn Thr 
1               5           


<210>  8
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  8

Val Val Asn His Ser Gly Gly Ser Tyr Ile Pro Thr Phe 
1               5                   10              


<210>  9
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  9

Leu Arg Trp Tyr Lys Gln Asp Thr Gly Arg Gly Pro Val Ser Leu Thr 
1               5                   10                  15      


Ile 
    


<210>  10
<211>  34
<212>  PRT
<213>  Homo sapiens

<400>  10

Lys Ser Asn Gly Arg Tyr Thr Ala Thr Leu Asp Ala Asp Thr Lys Gln 
1               5                   10                  15      


Ser Ser Leu His Ile Thr Ala Ser Gln Leu Ser Asp Ser Ala Ser Tyr 
            20                  25                  30          


Ile Cys 
        


<210>  11
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Asp His Glu Asn 
1               5   


<210>  12
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  12

Ser Tyr Asp Val Lys Met 
1               5       


<210>  13
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  13

Ala Ser Ser Phe Leu Met Thr Ser Gly Asp Pro Tyr Glu Gln Tyr Phe 
1               5                   10                  15      


<210>  14
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Phe Trp Tyr Arg Gln Asp Pro Gly Leu Gly Leu Arg Leu Ile Tyr 
1               5                   10                  15      


Phe 
    


<210>  15
<211>  37
<212>  PRT
<213>  Homo sapiens

<400>  15

Lys Glu Lys Gly Asp Ile Pro Glu Gly Tyr Ser Val Ser Arg Glu Lys 
1               5                   10                  15      


Lys Glu Arg Phe Ser Leu Ile Leu Glu Ser Ala Ser Thr Asn Gln Thr 
            20                  25                  30          


Ser Met Tyr Leu Cys 
        35          


<210>  16
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant alpha chain (c19v)

<400>  16

Lys Asn Gln Val Glu Gln Ser Pro Gln Ser Leu Ile Ile Leu Glu Gly 
1               5                   10                  15      


Lys Asn Val Thr Leu Gln Cys Asn Tyr Thr Val Ser Pro Phe Ser Asn 
            20                  25                  30          


Leu Arg Trp Tyr Lys Gln Asp Thr Gly Arg Gly Pro Val Ser Leu Thr 
        35                  40                  45              


Ile Met Thr Phe Ser Glu Asn Thr Lys Ser Asn Gly Arg Tyr Thr Ala 
    50                  55                  60                  


Thr Leu Asp Ala Asp Thr Lys Gln Ser Ser Leu His Ile Thr Ala Ser 
65                  70                  75                  80  


Gln Leu Ser Asp Ser Ala Ser Tyr Ile Cys Val Val Asn His Ser Gly 
                85                  90                  95      


Gly Ser Tyr Ile Pro Thr Phe Gly Arg Gly Thr Ser Leu Ile Val His 
            100                 105                 110         


Pro 
    


<210>  17
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant alpha chain (a7)

<400>  17

Lys Asn Gln Val Glu Gln Ser Pro Gln Ser Leu Ile Ile Leu Glu Gly 
1               5                   10                  15      


Lys Asn Val Thr Leu Gln Cys Asn Tyr Thr Val Ser Pro Phe Ser Asn 
            20                  25                  30          


Leu Arg Trp Tyr Lys Gln Asp Thr Gly Arg Gly Pro Val Ser Leu Thr 
        35                  40                  45              


Ile Leu Asp Tyr Ala Ile Asn Thr Lys Ser Asn Gly Arg Tyr Thr Ala 
    50                  55                  60                  


Thr Leu Asp Ala Asp Thr Lys Gln Ser Ser Leu His Ile Thr Ala Ser 
65                  70                  75                  80  


Gln Leu Ser Asp Ser Ala Ser Tyr Ile Cys Val Val Asn His Ser Gly 
                85                  90                  95      


Gly Ser Tyr Ile Pro Thr Phe Gly Arg Gly Thr Ser Leu Ile Val His 
            100                 105                 110         


Pro 
    


<210>  18
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant alpha chain (a12)

<400>  18

Lys Asn Gln Val Glu Gln Ser Pro Gln Ser Leu Ile Ile Leu Glu Gly 
1               5                   10                  15      


Lys Asn Val Thr Leu Gln Cys Asn Tyr Thr Val Ser Pro Phe Ser Asn 
            20                  25                  30          


Leu Arg Trp Tyr Lys Gln Asp Thr Gly Arg Gly Pro Val Ser Leu Thr 
        35                  40                  45              


Ile Met Thr Phe Ser Glu Asn Thr Lys Ser Asn Gly Arg Tyr Thr Ala 
    50                  55                  60                  


Thr Leu Asp Ala Asp Thr Lys Gln Ser Ser Leu His Ile Thr Ala Ser 
65                  70                  75                  80  


Gln Leu Ser Asp Ser Ala Ser Tyr Ile Cys Val Val Asn Arg Ala Asp 
                85                  90                  95      


Gly Leu Tyr Ile Pro Thr Phe Gly Arg Gly Thr Ser Leu Ile Val His 
            100                 105                 110         


Pro 
    


<210>  19
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant alpha chain (a13)

<400>  19

Lys Asn Gln Val Glu Gln Ser Pro Gln Ser Leu Ile Ile Leu Glu Gly 
1               5                   10                  15      


Lys Asn Val Thr Leu Gln Cys Asn Tyr Thr Val Ser Pro Phe Ser Asn 
            20                  25                  30          


Leu Arg Trp Tyr Lys Gln Asp Thr Gly Arg Gly Pro Val Ser Leu Thr 
        35                  40                  45              


Ile Met Thr Phe Ser Glu Asn Thr Lys Ser Asn Gly Arg Tyr Thr Ala 
    50                  55                  60                  


Thr Leu Asp Ala Asp Thr Lys Gln Ser Ser Leu His Ile Thr Ala Ser 
65                  70                  75                  80  


Gln Leu Ser Asp Ser Ala Ser Tyr Ile Cys Val Val Asn Ser Ala Asn 
                85                  90                  95      


Gly Leu Tyr Ile Pro Thr Phe Gly Arg Gly Thr Ser Leu Ile Val His 
            100                 105                 110         


Pro 
    


<210>  20
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant alpha chain (a13ka)

<400>  20

Ala Asn Gln Val Glu Gln Ser Pro Gln Ser Leu Ile Ile Leu Glu Gly 
1               5                   10                  15      


Lys Asn Val Thr Leu Gln Cys Asn Tyr Thr Val Ser Pro Phe Ser Asn 
            20                  25                  30          


Leu Arg Trp Tyr Lys Gln Asp Thr Gly Arg Gly Pro Val Ser Leu Thr 
        35                  40                  45              


Ile Met Thr Phe Ser Glu Asn Thr Lys Ser Asn Gly Arg Tyr Thr Ala 
    50                  55                  60                  


Thr Leu Asp Ala Asp Thr Lys Gln Ser Ser Leu His Ile Thr Ala Ser 
65                  70                  75                  80  


Gln Leu Ser Asp Ser Ala Ser Tyr Ile Cys Val Val Asn Ser Ala Asn 
                85                  90                  95      


Gly Leu Tyr Ile Pro Thr Phe Gly Arg Gly Thr Ser Leu Ile Val His 
            100                 105                 110         


Pro 
    


<210>  21
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant alpha chain (a19)

<400>  21

Lys Asn Gln Val Glu Gln Ser Pro Gln Ser Leu Ile Ile Leu Glu Gly 
1               5                   10                  15      


Lys Asn Val Thr Leu Gln Cys Asn Tyr Thr Val Ser Pro Phe Ser Asn 
            20                  25                  30          


Leu Arg Trp Tyr Lys Gln Asp Thr Gly Arg Gly Pro Val Ser Leu Thr 
        35                  40                  45              


Ile Leu Asp Tyr Ala Ile Asn Thr Lys Ser Asn Gly Arg Tyr Thr Ala 
    50                  55                  60                  


Thr Leu Asp Ala Asp Thr Lys Gln Ser Ser Leu His Ile Thr Ala Ser 
65                  70                  75                  80  


Gln Leu Ser Asp Ser Ala Ser Tyr Ile Cys Val Val Asn Arg Ala Asp 
                85                  90                  95      


Gly Leu Tyr Ile Pro Thr Phe Gly Arg Gly Thr Ser Leu Ile Val His 
            100                 105                 110         


Pro 
    


<210>  22
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant alpha chain (a19ka)

<400>  22

Ala Asn Gln Val Glu Gln Ser Pro Gln Ser Leu Ile Ile Leu Glu Gly 
1               5                   10                  15      


Lys Asn Val Thr Leu Gln Cys Asn Tyr Thr Val Ser Pro Phe Ser Asn 
            20                  25                  30          


Leu Arg Trp Tyr Lys Gln Asp Thr Gly Arg Gly Pro Val Ser Leu Thr 
        35                  40                  45              


Ile Leu Asp Tyr Ala Ile Asn Thr Lys Ser Asn Gly Arg Tyr Thr Ala 
    50                  55                  60                  


Thr Leu Asp Ala Asp Thr Lys Gln Ser Ser Leu His Ile Thr Ala Ser 
65                  70                  75                  80  


Gln Leu Ser Asp Ser Ala Ser Tyr Ile Cys Val Val Asn Arg Ala Asp 
                85                  90                  95      


Gly Leu Tyr Ile Pro Thr Phe Gly Arg Gly Thr Ser Leu Ile Val His 
            100                 105                 110         


Pro 
    


<210>  23
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant alpha chain (a13kaLS)

<400>  23

Ala Asn Gln Val Glu Gln Ser Pro Gln Ser Leu Ile Ile Leu Glu Gly 
1               5                   10                  15      


Lys Asn Val Thr Leu Gln Cys Asn Tyr Thr Val Ser Pro Phe Ser Asn 
            20                  25                  30          


Leu Arg Trp Tyr Lys Gln Asp Thr Gly Arg Gly Pro Val Ser Leu Thr 
        35                  40                  45              


Ile Leu Thr Phe Ser Glu Asn Thr Lys Ser Asn Gly Arg Tyr Thr Ala 
    50                  55                  60                  


Thr Leu Asp Ala Asp Thr Lys Gln Ser Ser Leu His Ile Thr Ala Ser 
65                  70                  75                  80  


Gln Leu Ser Asp Ser Ala Ser Tyr Ile Cys Val Val Asn Ser Ala Ser 
                85                  90                  95      


Gly Leu Tyr Ile Pro Thr Phe Gly Arg Gly Thr Ser Leu Ile Val His 
            100                 105                 110         


Pro 
    


<210>  24
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant alpha chain (a13kaLQ)

<400>  24

Ala Asn Gln Val Glu Gln Ser Pro Gln Ser Leu Ile Ile Leu Glu Gly 
1               5                   10                  15      


Lys Asn Val Thr Leu Gln Cys Asn Tyr Thr Val Ser Pro Phe Ser Asn 
            20                  25                  30          


Leu Arg Trp Tyr Lys Gln Asp Thr Gly Arg Gly Pro Val Ser Leu Thr 
        35                  40                  45              


Ile Leu Thr Phe Ser Glu Asn Thr Lys Ser Asn Gly Arg Tyr Thr Ala 
    50                  55                  60                  


Thr Leu Asp Ala Asp Thr Lys Gln Ser Ser Leu His Ile Thr Ala Ser 
65                  70                  75                  80  


Gln Leu Ser Asp Ser Ala Ser Tyr Ile Cys Val Val Asn Ser Ala Gln 
                85                  90                  95      


Gly Leu Tyr Ile Pro Thr Phe Gly Arg Gly Thr Ser Leu Ile Val His 
            100                 105                 110         


Pro 
    


<210>  25
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant beta chain (b1)

<400>  25

Asp Val Lys Val Thr Gln Ser Ser Arg Tyr Leu Val Lys Arg Thr Gly 
1               5                   10                  15      


Glu Lys Val Phe Leu Glu Cys Val Gln Asp Met Asp His Glu Asn Met 
            20                  25                  30          


Phe Trp Tyr Arg Gln Asp Pro Gly Leu Gly Leu Arg Leu Ile Tyr Phe 
        35                  40                  45              


Ser Tyr Asp Val Lys Met Lys Glu Lys Gly Asp Ile Pro Glu Gly Tyr 
    50                  55                  60                  


Ser Val Ser Arg Glu Lys Lys Glu Arg Phe Ser Leu Ile Leu Glu Ser 
65                  70                  75                  80  


Ala Ser Thr Asn Gln Thr Ser Met Tyr Leu Cys Ala Ser Ser Ser Asp 
                85                  90                  95      


Gln Asn Ser Gly Asp Pro Tyr Glu Gln Tyr Phe Gly Pro Gly Thr Arg 
            100                 105                 110         


Leu Thr Val Thr 
        115     


<210>  26
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant beta chain (b14)

<400>  26

Asp Val Lys Val Thr Gln Ser Ser Arg Tyr Leu Val Lys Arg Thr Gly 
1               5                   10                  15      


Glu Lys Val Phe Leu Glu Cys Val Gln Asp Ala Pro Leu Ser Lys Met 
            20                  25                  30          


Phe Trp Tyr Arg Gln Asp Pro Gly Leu Gly Leu Arg Leu Ile Tyr Phe 
        35                  40                  45              


Ser Tyr Asp Val Lys Met Lys Glu Lys Gly Asp Ile Pro Glu Gly Tyr 
    50                  55                  60                  


Ser Val Ser Arg Glu Lys Lys Glu Arg Phe Ser Leu Ile Leu Glu Ser 
65                  70                  75                  80  


Ala Ser Thr Asn Gln Thr Ser Met Tyr Leu Cys Ala Ser Ser Ser Asp 
                85                  90                  95      


Gln Asn Ser Gly Asp Pro Tyr Glu Gln Tyr Phe Gly Pro Gly Thr Arg 
            100                 105                 110         


Leu Thr Val Thr 
        115     


<210>  27
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant beta chain (b14L)

<400>  27

Asp Val Lys Val Thr Gln Ser Ser Arg Tyr Leu Val Lys Arg Thr Gly 
1               5                   10                  15      


Glu Lys Val Phe Leu Glu Cys Val Gln Asp Ala Pro Leu Ser Lys Met 
            20                  25                  30          


Phe Trp Tyr Arg Gln Asp Pro Gly Leu Gly Leu Arg Leu Ile Tyr Phe 
        35                  40                  45              


Ser Tyr Asp Val Lys Leu Lys Glu Lys Gly Asp Ile Pro Glu Gly Tyr 
    50                  55                  60                  


Ser Val Ser Arg Glu Lys Lys Glu Arg Phe Ser Leu Ile Leu Glu Ser 
65                  70                  75                  80  


Ala Ser Thr Asn Gln Thr Ser Met Tyr Leu Cys Ala Ser Ser Ser Asp 
                85                  90                  95      


Gln Asn Ser Gly Asp Pro Tyr Glu Gln Tyr Phe Gly Pro Gly Thr Arg 
            100                 105                 110         


Leu Thr Val Thr 
        115     


<210>  28
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant beta chain (b21)

<400>  28

Asp Val Lys Val Thr Gln Ser Ser Arg Tyr Leu Val Lys Arg Thr Gly 
1               5                   10                  15      


Glu Lys Val Phe Leu Glu Cys Val Gln Asp Met Asp His Glu Asn Met 
            20                  25                  30          


Phe Trp Tyr Arg Gln Asp Pro Gly Leu Gly Leu Arg Leu Ile Tyr Phe 
        35                  40                  45              


Ser Arg Phe Ala Thr Gly Lys Glu Lys Gly Asp Ile Pro Glu Gly Tyr 
    50                  55                  60                  


Ser Val Ser Arg Glu Lys Lys Glu Arg Phe Ser Leu Ile Leu Glu Ser 
65                  70                  75                  80  


Ala Ser Thr Asn Gln Thr Ser Met Tyr Leu Cys Ala Ser Ser Ser Asp 
                85                  90                  95      


Gln Asn Ser Gly Asp Pro Tyr Glu Gln Tyr Phe Gly Pro Gly Thr Arg 
            100                 105                 110         


Leu Thr Val Thr 
        115     


<210>  29
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant beta chain (b21L)

<400>  29

Asp Val Lys Val Thr Gln Ser Ser Arg Tyr Leu Val Lys Arg Thr Gly 
1               5                   10                  15      


Glu Lys Val Phe Leu Glu Cys Val Gln Asp Leu Asp His Glu Asn Met 
            20                  25                  30          


Phe Trp Tyr Arg Gln Asp Pro Gly Leu Gly Leu Arg Leu Ile Tyr Phe 
        35                  40                  45              


Ser Arg Phe Ala Thr Gly Lys Glu Lys Gly Asp Ile Pro Glu Gly Tyr 
    50                  55                  60                  


Ser Val Ser Arg Glu Lys Lys Glu Arg Phe Ser Leu Ile Leu Glu Ser 
65                  70                  75                  80  


Ala Ser Thr Asn Gln Thr Ser Met Tyr Leu Cys Ala Ser Ser Ser Asp 
                85                  90                  95      


Gln Asn Ser Gly Asp Pro Tyr Glu Gln Tyr Phe Gly Pro Gly Thr Arg 
            100                 105                 110         


Leu Thr Val Thr 
        115     


<210>  30
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker Sequence

<400>  30

Gly Gly Gly Gly Ser 
1               5   


<210>  31
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker Sequence

<400>  31

Gly Gly Gly Ser Gly 
1               5   


<210>  32
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker Sequence

<400>  32

Gly Gly Ser Gly Gly 
1               5   


<210>  33
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker Sequence

<400>  33

Gly Ser Gly Gly Gly 
1               5   


<210>  34
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker Sequence

<400>  34

Gly Ser Gly Gly Gly Pro 
1               5       


<210>  35
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker Sequence

<400>  35

Gly Gly Glu Pro Ser 
1               5   


<210>  36
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker Sequence

<400>  36

Gly Gly Glu Gly Gly Gly Pro 
1               5           


<210>  37
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker Sequence

<400>  37

Gly Gly Glu Gly Gly Gly Ser Glu Gly Gly Gly Ser 
1               5                   10          


<210>  38
<211>  199
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  alpha chain (a19ka)

<400>  38

Ala Asn Gln Val Glu Gln Ser Pro Gln Ser Leu Ile Ile Leu Glu Gly 
1               5                   10                  15      


Lys Asn Val Thr Leu Gln Cys Asn Tyr Thr Val Ser Pro Phe Ser Asn 
            20                  25                  30          


Leu Arg Trp Tyr Lys Gln Asp Thr Gly Arg Gly Pro Val Ser Leu Thr 
        35                  40                  45              


Ile Leu Asp Tyr Ala Ile Asn Thr Lys Ser Asn Gly Arg Tyr Thr Ala 
    50                  55                  60                  


Thr Leu Asp Ala Asp Thr Lys Gln Ser Ser Leu His Ile Thr Ala Ser 
65                  70                  75                  80  


Gln Leu Ser Asp Ser Ala Ser Tyr Ile Cys Val Val Asn Arg Ala Asp 
                85                  90                  95      


Gly Leu Tyr Ile Pro Thr Phe Gly Arg Gly Thr Ser Leu Ile Val His 
            100                 105                 110         


Pro Tyr Ile Gln Lys Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser 
        115                 120                 125             


Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Gln 
    130                 135                 140                 


Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys 
145                 150                 155                 160 


Cys Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala Val 
                165                 170                 175     


Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn 
            180                 185                 190         


Ser Ile Ile Pro Glu Asp Thr 
        195                 


<210>  39
<211>  199
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  alpha chain (a13ka)

<400>  39

Ala Asn Gln Val Glu Gln Ser Pro Gln Ser Leu Ile Ile Leu Glu Gly 
1               5                   10                  15      


Lys Asn Val Thr Leu Gln Cys Asn Tyr Thr Val Ser Pro Phe Ser Asn 
            20                  25                  30          


Leu Arg Trp Tyr Lys Gln Asp Thr Gly Arg Gly Pro Val Ser Leu Thr 
        35                  40                  45              


Ile Met Thr Phe Ser Glu Asn Thr Lys Ser Asn Gly Arg Tyr Thr Ala 
    50                  55                  60                  


Thr Leu Asp Ala Asp Thr Lys Gln Ser Ser Leu His Ile Thr Ala Ser 
65                  70                  75                  80  


Gln Leu Ser Asp Ser Ala Ser Tyr Ile Cys Val Val Asn Ser Ala Asn 
                85                  90                  95      


Gly Leu Tyr Ile Pro Thr Phe Gly Arg Gly Thr Ser Leu Ile Val His 
            100                 105                 110         


Pro Tyr Ile Gln Lys Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser 
        115                 120                 125             


Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Gln 
    130                 135                 140                 


Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys 
145                 150                 155                 160 


Cys Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala Val 
                165                 170                 175     


Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn 
            180                 185                 190         


Ser Ile Ile Pro Glu Asp Thr 
        195                 


<210>  40
<211>  199
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  alpha chain (a13kaLQ)

<400>  40

Ala Asn Gln Val Glu Gln Ser Pro Gln Ser Leu Ile Ile Leu Glu Gly 
1               5                   10                  15      


Lys Asn Val Thr Leu Gln Cys Asn Tyr Thr Val Ser Pro Phe Ser Asn 
            20                  25                  30          


Leu Arg Trp Tyr Lys Gln Asp Thr Gly Arg Gly Pro Val Ser Leu Thr 
        35                  40                  45              


Ile Leu Thr Phe Ser Glu Asn Thr Lys Ser Asn Gly Arg Tyr Thr Ala 
    50                  55                  60                  


Thr Leu Asp Ala Asp Thr Lys Gln Ser Ser Leu His Ile Thr Ala Ser 
65                  70                  75                  80  


Gln Leu Ser Asp Ser Ala Ser Tyr Ile Cys Val Val Asn Ser Ala Gln 
                85                  90                  95      


Gly Leu Tyr Ile Pro Thr Phe Gly Arg Gly Thr Ser Leu Ile Val His 
            100                 105                 110         


Pro Tyr Ile Gln Lys Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser 
        115                 120                 125             


Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Gln 
    130                 135                 140                 


Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys 
145                 150                 155                 160 


Cys Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala Val 
                165                 170                 175     


Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn 
            180                 185                 190         


Ser Ile Ile Pro Glu Asp Thr 
        195                 


<210>  41
<211>  199
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  alpha chain (a13kaLS)

<400>  41

Ala Asn Gln Val Glu Gln Ser Pro Gln Ser Leu Ile Ile Leu Glu Gly 
1               5                   10                  15      


Lys Asn Val Thr Leu Gln Cys Asn Tyr Thr Val Ser Pro Phe Ser Asn 
            20                  25                  30          


Leu Arg Trp Tyr Lys Gln Asp Thr Gly Arg Gly Pro Val Ser Leu Thr 
        35                  40                  45              


Ile Leu Thr Phe Ser Glu Asn Thr Lys Ser Asn Gly Arg Tyr Thr Ala 
    50                  55                  60                  


Thr Leu Asp Ala Asp Thr Lys Gln Ser Ser Leu His Ile Thr Ala Ser 
65                  70                  75                  80  


Gln Leu Ser Asp Ser Ala Ser Tyr Ile Cys Val Val Asn Ser Ala Ser 
                85                  90                  95      


Gly Leu Tyr Ile Pro Thr Phe Gly Arg Gly Thr Ser Leu Ile Val His 
            100                 105                 110         


Pro Tyr Ile Gln Lys Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser 
        115                 120                 125             


Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Gln 
    130                 135                 140                 


Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys 
145                 150                 155                 160 


Cys Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala Val 
                165                 170                 175     


Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn 
            180                 185                 190         


Ser Ile Ile Pro Glu Asp Thr 
        195                 


<210>  42
<211>  504
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  beta chain (b14)

<400>  42

Ala Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Arg Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Asn Thr Leu Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
    130                 135                 140                 


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Ser Phe 
145                 150                 155                 160 


Thr Gly Tyr Thr Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
                165                 170                 175     


Glu Trp Val Ala Leu Ile Asn Pro Tyr Lys Gly Val Ser Thr Tyr Asn 
            180                 185                 190         


Gln Lys Phe Lys Asp Arg Phe Thr Ile Ser Val Asp Lys Ser Lys Asn 
        195                 200                 205             


Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
    210                 215                 220                 


Tyr Tyr Cys Ala Arg Ser Gly Tyr Tyr Gly Asp Ser Asp Trp Tyr Phe 
225                 230                 235                 240 


Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
                245                 250                 255     


Gly Ser Asp Val Lys Val Thr Gln Ser Ser Arg Tyr Leu Val Lys Arg 
            260                 265                 270         


Thr Gly Glu Lys Val Phe Leu Glu Cys Val Gln Asp Ala Pro Leu Ser 
        275                 280                 285             


Lys Met Phe Trp Tyr Arg Gln Asp Pro Gly Leu Gly Leu Arg Leu Ile 
    290                 295                 300                 


Tyr Phe Ser Tyr Asp Val Lys Met Lys Glu Lys Gly Asp Ile Pro Glu 
305                 310                 315                 320 


Gly Tyr Ser Val Ser Arg Glu Lys Lys Glu Arg Phe Ser Leu Ile Leu 
                325                 330                 335     


Glu Ser Ala Ser Thr Asn Gln Thr Ser Met Tyr Leu Cys Ala Ser Ser 
            340                 345                 350         


Ser Asp Gln Asn Ser Gly Asp Pro Tyr Glu Gln Tyr Phe Gly Pro Gly 
        355                 360                 365             


Thr Arg Leu Thr Val Thr Glu Asp Leu Lys Asn Val Phe Pro Pro Glu 
    370                 375                 380                 


Val Ala Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys 
385                 390                 395                 400 


Ala Thr Leu Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu 
                405                 410                 415     


Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr 
            420                 425                 430         


Asp Pro Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr 
        435                 440                 445             


Ala Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asp Pro 
    450                 455                 460                 


Arg Asn His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn 
465                 470                 475                 480 


Asp Glu Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser 
                485                 490                 495     


Ala Glu Ala Trp Gly Arg Ala Asp 
            500                 


<210>  43
<211>  504
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  beta chain (b14L)

<400>  43

Ala Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Arg Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Asn Thr Leu Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
    130                 135                 140                 


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Ser Phe 
145                 150                 155                 160 


Thr Gly Tyr Thr Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
                165                 170                 175     


Glu Trp Val Ala Leu Ile Asn Pro Tyr Lys Gly Val Ser Thr Tyr Asn 
            180                 185                 190         


Gln Lys Phe Lys Asp Arg Phe Thr Ile Ser Val Asp Lys Ser Lys Asn 
        195                 200                 205             


Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
    210                 215                 220                 


Tyr Tyr Cys Ala Arg Ser Gly Tyr Tyr Gly Asp Ser Asp Trp Tyr Phe 
225                 230                 235                 240 


Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
                245                 250                 255     


Gly Ser Asp Val Lys Val Thr Gln Ser Ser Arg Tyr Leu Val Lys Arg 
            260                 265                 270         


Thr Gly Glu Lys Val Phe Leu Glu Cys Val Gln Asp Ala Pro Leu Ser 
        275                 280                 285             


Lys Met Phe Trp Tyr Arg Gln Asp Pro Gly Leu Gly Leu Arg Leu Ile 
    290                 295                 300                 


Tyr Phe Ser Tyr Asp Val Lys Leu Lys Glu Lys Gly Asp Ile Pro Glu 
305                 310                 315                 320 


Gly Tyr Ser Val Ser Arg Glu Lys Lys Glu Arg Phe Ser Leu Ile Leu 
                325                 330                 335     


Glu Ser Ala Ser Thr Asn Gln Thr Ser Met Tyr Leu Cys Ala Ser Ser 
            340                 345                 350         


Ser Asp Gln Asn Ser Gly Asp Pro Tyr Glu Gln Tyr Phe Gly Pro Gly 
        355                 360                 365             


Thr Arg Leu Thr Val Thr Glu Asp Leu Lys Asn Val Phe Pro Pro Glu 
    370                 375                 380                 


Val Ala Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys 
385                 390                 395                 400 


Ala Thr Leu Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu 
                405                 410                 415     


Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr 
            420                 425                 430         


Asp Pro Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr 
        435                 440                 445             


Ala Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asp Pro 
    450                 455                 460                 


Arg Asn His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn 
465                 470                 475                 480 


Asp Glu Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser 
                485                 490                 495     


Ala Glu Ala Trp Gly Arg Ala Asp 
            500                 


<210>  44
<211>  504
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  beta chain (b21)

<400>  44

Ala Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Arg Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Asn Thr Leu Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
    130                 135                 140                 


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Ser Phe 
145                 150                 155                 160 


Thr Gly Tyr Thr Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
                165                 170                 175     


Glu Trp Val Ala Leu Ile Asn Pro Tyr Lys Gly Val Ser Thr Tyr Asn 
            180                 185                 190         


Gln Lys Phe Lys Asp Arg Phe Thr Ile Ser Val Asp Lys Ser Lys Asn 
        195                 200                 205             


Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
    210                 215                 220                 


Tyr Tyr Cys Ala Arg Ser Gly Tyr Tyr Gly Asp Ser Asp Trp Tyr Phe 
225                 230                 235                 240 


Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
                245                 250                 255     


Gly Ser Asp Val Lys Val Thr Gln Ser Ser Arg Tyr Leu Val Lys Arg 
            260                 265                 270         


Thr Gly Glu Lys Val Phe Leu Glu Cys Val Gln Asp Met Asp His Glu 
        275                 280                 285             


Asn Met Phe Trp Tyr Arg Gln Asp Pro Gly Leu Gly Leu Arg Leu Ile 
    290                 295                 300                 


Tyr Phe Ser Arg Phe Ala Thr Gly Lys Glu Lys Gly Asp Ile Pro Glu 
305                 310                 315                 320 


Gly Tyr Ser Val Ser Arg Glu Lys Lys Glu Arg Phe Ser Leu Ile Leu 
                325                 330                 335     


Glu Ser Ala Ser Thr Asn Gln Thr Ser Met Tyr Leu Cys Ala Ser Ser 
            340                 345                 350         


Ser Asp Gln Asn Ser Gly Asp Pro Tyr Glu Gln Tyr Phe Gly Pro Gly 
        355                 360                 365             


Thr Arg Leu Thr Val Thr Glu Asp Leu Lys Asn Val Phe Pro Pro Glu 
    370                 375                 380                 


Val Ala Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys 
385                 390                 395                 400 


Ala Thr Leu Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu 
                405                 410                 415     


Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr 
            420                 425                 430         


Asp Pro Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr 
        435                 440                 445             


Ala Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asp Pro 
    450                 455                 460                 


Arg Asn His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn 
465                 470                 475                 480 


Asp Glu Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser 
                485                 490                 495     


Ala Glu Ala Trp Gly Arg Ala Asp 
            500                 


<210>  45
<211>  504
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  beta chain (b21L)

<400>  45

Ala Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Arg Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Asn Thr Leu Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
    130                 135                 140                 


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Ser Phe 
145                 150                 155                 160 


Thr Gly Tyr Thr Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
                165                 170                 175     


Glu Trp Val Ala Leu Ile Asn Pro Tyr Lys Gly Val Ser Thr Tyr Asn 
            180                 185                 190         


Gln Lys Phe Lys Asp Arg Phe Thr Ile Ser Val Asp Lys Ser Lys Asn 
        195                 200                 205             


Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
    210                 215                 220                 


Tyr Tyr Cys Ala Arg Ser Gly Tyr Tyr Gly Asp Ser Asp Trp Tyr Phe 
225                 230                 235                 240 


Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
                245                 250                 255     


Gly Ser Asp Val Lys Val Thr Gln Ser Ser Arg Tyr Leu Val Lys Arg 
            260                 265                 270         


Thr Gly Glu Lys Val Phe Leu Glu Cys Val Gln Asp Leu Asp His Glu 
        275                 280                 285             


Asn Met Phe Trp Tyr Arg Gln Asp Pro Gly Leu Gly Leu Arg Leu Ile 
    290                 295                 300                 


Tyr Phe Ser Arg Phe Ala Thr Gly Lys Glu Lys Gly Asp Ile Pro Glu 
305                 310                 315                 320 


Gly Tyr Ser Val Ser Arg Glu Lys Lys Glu Arg Phe Ser Leu Ile Leu 
                325                 330                 335     


Glu Ser Ala Ser Thr Asn Gln Thr Ser Met Tyr Leu Cys Ala Ser Ser 
            340                 345                 350         


Ser Asp Gln Asn Ser Gly Asp Pro Tyr Glu Gln Tyr Phe Gly Pro Gly 
        355                 360                 365             


Thr Arg Leu Thr Val Thr Glu Asp Leu Lys Asn Val Phe Pro Pro Glu 
    370                 375                 380                 


Val Ala Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys 
385                 390                 395                 400 


Ala Thr Leu Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu 
                405                 410                 415     


Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr 
            420                 425                 430         


Asp Pro Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr 
        435                 440                 445             


Ala Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asp Pro 
    450                 455                 460                 


Arg Asn His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn 
465                 470                 475                 480 


Asp Glu Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser 
                485                 490                 495     


Ala Glu Ala Trp Gly Arg Ala Asp 
            500                 


<210>  46
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant alpha chain (a36)

<400>  46

Ala Asn Gln Val Glu Gln Ser Pro Gln Ser Leu Ile Ile Leu Glu Gly 
1               5                   10                  15      


Lys Asn Val Thr Leu Gln Cys Asn Tyr Thr Val Ser Pro Phe Ser Asn 
            20                  25                  30          


Leu Arg Trp Tyr Lys Gln Asp Thr Gly Arg Gly Pro Val Ser Leu Thr 
        35                  40                  45              


Ile Met Thr Phe Ser Glu Asn Thr Lys Ser Asn Gly Arg Tyr Thr Ala 
    50                  55                  60                  


Thr Leu Asp Ala Asp Thr Lys Gln Ser Ser Leu His Ile Thr Ala Ser 
65                  70                  75                  80  


Gln Leu Ser Asp Ser Ala Ser Tyr Ile Cys Val Val Asn Ser Ala Gln 
                85                  90                  95      


Gly Leu Tyr Ile Pro Thr Phe Gly Arg Gly Thr Ser Leu Ile Val His 
            100                 105                 110         


Pro 
    


<210>  47
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant alpha chain (a37)

<400>  47

Ala Asn Gln Val Glu Gln Ser Pro Gln Ser Leu Ile Ile Leu Glu Gly 
1               5                   10                  15      


Lys Asn Val Thr Leu Gln Cys Asn Tyr Thr Val Ser Pro Phe Ser Asn 
            20                  25                  30          


Leu Arg Trp Tyr Lys Gln Asp Thr Gly Arg Gly Pro Val Ser Leu Thr 
        35                  40                  45              


Ile Leu Thr Tyr Ser Glu Asn Thr Lys Ser Asn Gly Arg Tyr Thr Ala 
    50                  55                  60                  


Thr Leu Asp Ala Asp Thr Lys Gln Ser Ser Leu His Ile Thr Ala Ser 
65                  70                  75                  80  


Gln Leu Ser Asp Ser Ala Ser Tyr Ile Cys Val Val Asn Ser Ala Gln 
                85                  90                  95      


Gly Leu Tyr Ile Pro Thr Phe Gly Arg Gly Thr Ser Leu Ile Val His 
            100                 105                 110         


Pro 
    


<210>  48
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant alpha chain (a38)

<400>  48

Ala Asn Gln Val Glu Gln Ser Pro Gln Ser Leu Ile Ile Leu Glu Gly 
1               5                   10                  15      


Lys Asn Val Thr Leu Gln Cys Asn Tyr Thr Val Ser Pro Phe Ser Asn 
            20                  25                  30          


Leu Arg Trp Tyr Lys Gln Asp Thr Gly Arg Gly Pro Val Ser Leu Thr 
        35                  40                  45              


Ile Leu Thr Phe Ser Glu Asn Thr Lys Ser Asn Gly Arg Tyr Thr Ala 
    50                  55                  60                  


Thr Leu Asp Ala Asp Thr Lys Gln Ser Ser Leu His Ile Thr Ala Ser 
65                  70                  75                  80  


Gln Leu Ser Asp Ser Ala Ser Tyr Ile Cys Val Val Asn His Ala Gln 
                85                  90                  95      


Gly Leu Tyr Ile Pro Thr Phe Gly Arg Gly Thr Ser Leu Ile Val His 
            100                 105                 110         


Pro 
    


<210>  49
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant alpha chain (a39)

<400>  49

Ala Asn Gln Val Glu Gln Ser Pro Gln Ser Leu Ile Ile Leu Glu Gly 
1               5                   10                  15      


Lys Asn Val Thr Leu Gln Cys Asn Tyr Thr Val Ser Pro Phe Ser Asn 
            20                  25                  30          


Leu Arg Trp Tyr Lys Gln Asp Thr Gly Arg Gly Pro Val Ser Leu Thr 
        35                  40                  45              


Ile Leu Thr Phe Ser Glu Asn Thr Lys Ser Asn Gly Arg Tyr Thr Ala 
    50                  55                  60                  


Thr Leu Asp Ala Asp Thr Lys Gln Ser Ser Leu His Ile Thr Ala Ser 
65                  70                  75                  80  


Gln Leu Ser Asp Ser Ala Ser Tyr Ile Cys Val Val Asn Ser Ser Gln 
                85                  90                  95      


Gly Leu Tyr Ile Pro Thr Phe Gly Arg Gly Thr Ser Leu Ile Val His 
            100                 105                 110         


Pro 
    


<210>  50
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant alpha chain (a40)

<400>  50

Ala Asn Gln Val Glu Gln Ser Pro Gln Ser Leu Ile Ile Leu Glu Gly 
1               5                   10                  15      


Lys Asn Val Thr Leu Gln Cys Asn Tyr Thr Val Ser Pro Phe Ser Asn 
            20                  25                  30          


Leu Arg Trp Tyr Lys Gln Asp Thr Gly Arg Gly Pro Val Ser Leu Thr 
        35                  40                  45              


Ile Leu Thr Phe Ser Glu Asn Thr Lys Ser Asn Gly Arg Tyr Thr Ala 
    50                  55                  60                  


Thr Leu Asp Ala Asp Thr Lys Gln Ser Ser Leu His Ile Thr Ala Ser 
65                  70                  75                  80  


Gln Leu Ser Asp Ser Ala Ser Tyr Ile Cys Val Val Asn Ser Ala Gly 
                85                  90                  95      


Gly Leu Tyr Ile Pro Thr Phe Gly Arg Gly Thr Ser Leu Ile Val His 
            100                 105                 110         


Pro 
    


<210>  51
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant alpha chain (a41)

<400>  51

Ala Asn Gln Val Glu Gln Ser Pro Gln Ser Leu Ile Ile Leu Glu Gly 
1               5                   10                  15      


Lys Asn Val Thr Leu Gln Cys Asn Tyr Thr Val Ser Pro Phe Ser Asn 
            20                  25                  30          


Leu Arg Trp Tyr Lys Gln Asp Thr Gly Arg Gly Pro Val Ser Leu Thr 
        35                  40                  45              


Ile Leu Thr Phe Ser Glu Asn Thr Lys Ser Asn Gly Arg Tyr Thr Ala 
    50                  55                  60                  


Thr Leu Asp Ala Asp Thr Lys Gln Ser Ser Leu His Ile Thr Ala Ser 
65                  70                  75                  80  


Gln Leu Ser Asp Ser Ala Ser Tyr Ile Cys Val Val Asn Ser Ala Gln 
                85                  90                  95      


Gly Ser Tyr Ile Pro Thr Phe Gly Arg Gly Thr Ser Leu Ile Val His 
            100                 105                 110         


Pro 
    


<210>  52
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant alpha chain (a30)

<400>  52

Ala Asn Gln Val Glu Gln Ser Pro Gln Ser Leu Ile Ile Leu Glu Gly 
1               5                   10                  15      


Lys Asn Val Thr Leu Gln Cys Asn Tyr Thr Val Ser Pro Phe Ser Asn 
            20                  25                  30          


Leu Arg Trp Tyr Lys Gln Asp Thr Gly Arg Gly Pro Val Ser Leu Thr 
        35                  40                  45              


Ile Met Asp Tyr Ala Ile Asn Thr Lys Ser Asn Gly Arg Tyr Thr Ala 
    50                  55                  60                  


Thr Leu Asp Ala Asp Thr Lys Gln Ser Ser Leu His Ile Thr Ala Ser 
65                  70                  75                  80  


Gln Leu Ser Asp Ser Ala Ser Tyr Ile Cys Val Val Asn Arg Ala Asp 
                85                  90                  95      


Gly Leu Tyr Ile Pro Thr Phe Gly Arg Gly Thr Ser Leu Ile Val His 
            100                 105                 110         


Pro 
    


<210>  53
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant alpha chain (a42)

<400>  53

Ala Asn Gln Val Glu Gln Ser Pro Gln Ser Leu Ile Ile Leu Glu Gly 
1               5                   10                  15      


Lys Asn Val Thr Leu Gln Cys Asn Tyr Thr Val Ser Pro Phe Ser Asn 
            20                  25                  30          


Leu Arg Trp Tyr Lys Gln Asp Thr Gly Arg Gly Pro Val Ser Leu Thr 
        35                  40                  45              


Ile Leu Thr Tyr Ala Ile Asn Thr Lys Ser Asn Gly Arg Tyr Thr Ala 
    50                  55                  60                  


Thr Leu Asp Ala Asp Thr Lys Gln Ser Ser Leu His Ile Thr Ala Ser 
65                  70                  75                  80  


Gln Leu Ser Asp Ser Ala Ser Tyr Ile Cys Val Val Asn Arg Ala Asp 
                85                  90                  95      


Gly Leu Tyr Ile Pro Thr Phe Gly Arg Gly Thr Ser Leu Ile Val His 
            100                 105                 110         


Pro 
    


<210>  54
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant alpha chain (a31)

<400>  54

Ala Asn Gln Val Glu Gln Ser Pro Gln Ser Leu Ile Ile Leu Glu Gly 
1               5                   10                  15      


Lys Asn Val Thr Leu Gln Cys Asn Tyr Thr Val Ser Pro Phe Ser Asn 
            20                  25                  30          


Leu Arg Trp Tyr Lys Gln Asp Thr Gly Arg Gly Pro Val Ser Leu Thr 
        35                  40                  45              


Ile Leu Asp Phe Ala Ile Asn Thr Lys Ser Asn Gly Arg Tyr Thr Ala 
    50                  55                  60                  


Thr Leu Asp Ala Asp Thr Lys Gln Ser Ser Leu His Ile Thr Ala Ser 
65                  70                  75                  80  


Gln Leu Ser Asp Ser Ala Ser Tyr Ile Cys Val Val Asn Arg Ala Asp 
                85                  90                  95      


Gly Leu Tyr Ile Pro Thr Phe Gly Arg Gly Thr Ser Leu Ile Val His 
            100                 105                 110         


Pro 
    


<210>  55
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant alpha chain (a43)

<400>  55

Ala Asn Gln Val Glu Gln Ser Pro Gln Ser Leu Ile Ile Leu Glu Gly 
1               5                   10                  15      


Lys Asn Val Thr Leu Gln Cys Asn Tyr Thr Val Ser Pro Phe Ser Asn 
            20                  25                  30          


Leu Arg Trp Tyr Lys Gln Asp Thr Gly Arg Gly Pro Val Ser Leu Thr 
        35                  40                  45              


Ile Leu Asp Tyr Ser Ile Asn Thr Lys Ser Asn Gly Arg Tyr Thr Ala 
    50                  55                  60                  


Thr Leu Asp Ala Asp Thr Lys Gln Ser Ser Leu His Ile Thr Ala Ser 
65                  70                  75                  80  


Gln Leu Ser Asp Ser Ala Ser Tyr Ile Cys Val Val Asn Arg Ala Asp 
                85                  90                  95      


Gly Leu Tyr Ile Pro Thr Phe Gly Arg Gly Thr Ser Leu Ile Val His 
            100                 105                 110         


Pro 
    


<210>  56
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant alpha chain (a32)

<400>  56

Ala Asn Gln Val Glu Gln Ser Pro Gln Ser Leu Ile Ile Leu Glu Gly 
1               5                   10                  15      


Lys Asn Val Thr Leu Gln Cys Asn Tyr Thr Val Ser Pro Phe Ser Asn 
            20                  25                  30          


Leu Arg Trp Tyr Lys Gln Asp Thr Gly Arg Gly Pro Val Ser Leu Thr 
        35                  40                  45              


Ile Leu Asp Tyr Ala Glu Asn Thr Lys Ser Asn Gly Arg Tyr Thr Ala 
    50                  55                  60                  


Thr Leu Asp Ala Asp Thr Lys Gln Ser Ser Leu His Ile Thr Ala Ser 
65                  70                  75                  80  


Gln Leu Ser Asp Ser Ala Ser Tyr Ile Cys Val Val Asn Arg Ala Asp 
                85                  90                  95      


Gly Leu Tyr Ile Pro Thr Phe Gly Arg Gly Thr Ser Leu Ile Val His 
            100                 105                 110         


Pro 
    


<210>  57
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant alpha chain (a44)

<400>  57

Ala Asn Gln Val Glu Gln Ser Pro Gln Ser Leu Ile Ile Leu Glu Gly 
1               5                   10                  15      


Lys Asn Val Thr Leu Gln Cys Asn Tyr Thr Val Ser Pro Phe Ser Asn 
            20                  25                  30          


Leu Arg Trp Tyr Lys Gln Asp Thr Gly Arg Gly Pro Val Ser Leu Thr 
        35                  40                  45              


Ile Leu Asp Tyr Ala Ile Asn Thr Lys Ser Asn Gly Arg Tyr Thr Ala 
    50                  55                  60                  


Thr Leu Asp Ala Asp Thr Lys Gln Ser Ser Leu His Ile Thr Ala Ser 
65                  70                  75                  80  


Gln Leu Ser Asp Ser Ala Ser Tyr Ile Cys Val Val Asn His Ala Asp 
                85                  90                  95      


Gly Leu Tyr Ile Pro Thr Phe Gly Arg Gly Thr Ser Leu Ile Val His 
            100                 105                 110         


Pro 
    


<210>  58
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant alpha chain (a33)

<400>  58

Ala Asn Gln Val Glu Gln Ser Pro Gln Ser Leu Ile Ile Leu Glu Gly 
1               5                   10                  15      


Lys Asn Val Thr Leu Gln Cys Asn Tyr Thr Val Ser Pro Phe Ser Asn 
            20                  25                  30          


Leu Arg Trp Tyr Lys Gln Asp Thr Gly Arg Gly Pro Val Ser Leu Thr 
        35                  40                  45              


Ile Leu Asp Tyr Ala Ile Asn Thr Lys Ser Asn Gly Arg Tyr Thr Ala 
    50                  55                  60                  


Thr Leu Asp Ala Asp Thr Lys Gln Ser Ser Leu His Ile Thr Ala Ser 
65                  70                  75                  80  


Gln Leu Ser Asp Ser Ala Ser Tyr Ile Cys Val Val Asn Arg Ser Asp 
                85                  90                  95      


Gly Leu Tyr Ile Pro Thr Phe Gly Arg Gly Thr Ser Leu Ile Val His 
            100                 105                 110         


Pro 
    


<210>  59
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant alpha chain (a45)

<400>  59

Ala Asn Gln Val Glu Gln Ser Pro Gln Ser Leu Ile Ile Leu Glu Gly 
1               5                   10                  15      


Lys Asn Val Thr Leu Gln Cys Asn Tyr Thr Val Ser Pro Phe Ser Asn 
            20                  25                  30          


Leu Arg Trp Tyr Lys Gln Asp Thr Gly Arg Gly Pro Val Ser Leu Thr 
        35                  40                  45              


Ile Leu Asp Tyr Ala Ile Asn Thr Lys Ser Asn Gly Arg Tyr Thr Ala 
    50                  55                  60                  


Thr Leu Asp Ala Asp Thr Lys Gln Ser Ser Leu His Ile Thr Ala Ser 
65                  70                  75                  80  


Gln Leu Ser Asp Ser Ala Ser Tyr Ile Cys Val Val Asn Arg Ala Gly 
                85                  90                  95      


Gly Leu Tyr Ile Pro Thr Phe Gly Arg Gly Thr Ser Leu Ile Val His 
            100                 105                 110         


Pro 
    


<210>  60
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant alpha chain (a34)

<400>  60

Ala Asn Gln Val Glu Gln Ser Pro Gln Ser Leu Ile Ile Leu Glu Gly 
1               5                   10                  15      


Lys Asn Val Thr Leu Gln Cys Asn Tyr Thr Val Ser Pro Phe Ser Asn 
            20                  25                  30          


Leu Arg Trp Tyr Lys Gln Asp Thr Gly Arg Gly Pro Val Ser Leu Thr 
        35                  40                  45              


Ile Leu Asp Tyr Ala Ile Asn Thr Lys Ser Asn Gly Arg Tyr Thr Ala 
    50                  55                  60                  


Thr Leu Asp Ala Asp Thr Lys Gln Ser Ser Leu His Ile Thr Ala Ser 
65                  70                  75                  80  


Gln Leu Ser Asp Ser Ala Ser Tyr Ile Cys Val Val Asn Arg Ala Asp 
                85                  90                  95      


Gly Ser Tyr Ile Pro Thr Phe Gly Arg Gly Thr Ser Leu Ile Val His 
            100                 105                 110         


Pro 
    


<210>  61
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant alpha chain (aWTka)

<400>  61

Ala Asn Gln Val Glu Gln Ser Pro Gln Ser Leu Ile Ile Leu Glu Gly 
1               5                   10                  15      


Lys Asn Val Thr Leu Gln Cys Asn Tyr Thr Val Ser Pro Phe Ser Asn 
            20                  25                  30          


Leu Arg Trp Tyr Lys Gln Asp Thr Gly Arg Gly Pro Val Ser Leu Thr 
        35                  40                  45              


Ile Met Thr Phe Ser Glu Asn Thr Lys Ser Asn Gly Arg Tyr Thr Ala 
    50                  55                  60                  


Thr Leu Asp Ala Asp Thr Lys Gln Ser Ser Leu His Ile Thr Ala Ser 
65                  70                  75                  80  


Gln Leu Ser Asp Ser Ala Ser Tyr Ile Cys Val Val Asn His Ser Gly 
                85                  90                  95      


Gly Ser Tyr Ile Pro Thr Phe Gly Arg Gly Thr Ser Leu Ile Val His 
            100                 105                 110         


Pro 
    


<210>  62
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant alpha chain (aM50L)

<400>  62

Ala Asn Gln Val Glu Gln Ser Pro Gln Ser Leu Ile Ile Leu Glu Gly 
1               5                   10                  15      


Lys Asn Val Thr Leu Gln Cys Asn Tyr Thr Val Ser Pro Phe Ser Asn 
            20                  25                  30          


Leu Arg Trp Tyr Lys Gln Asp Thr Gly Arg Gly Pro Val Ser Leu Thr 
        35                  40                  45              


Ile Leu Thr Phe Ser Glu Asn Thr Lys Ser Asn Gly Arg Tyr Thr Ala 
    50                  55                  60                  


Thr Leu Asp Ala Asp Thr Lys Gln Ser Ser Leu His Ile Thr Ala Ser 
65                  70                  75                  80  


Gln Leu Ser Asp Ser Ala Ser Tyr Ile Cys Val Val Asn His Ser Gly 
                85                  90                  95      


Gly Ser Tyr Ile Pro Thr Phe Gly Arg Gly Thr Ser Leu Ile Val His 
            100                 105                 110         


Pro 
    


<210>  63
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant alpha chain (aS95A)

<400>  63

Ala Asn Gln Val Glu Gln Ser Pro Gln Ser Leu Ile Ile Leu Glu Gly 
1               5                   10                  15      


Lys Asn Val Thr Leu Gln Cys Asn Tyr Thr Val Ser Pro Phe Ser Asn 
            20                  25                  30          


Leu Arg Trp Tyr Lys Gln Asp Thr Gly Arg Gly Pro Val Ser Leu Thr 
        35                  40                  45              


Ile Met Thr Phe Ser Glu Asn Thr Lys Ser Asn Gly Arg Tyr Thr Ala 
    50                  55                  60                  


Thr Leu Asp Ala Asp Thr Lys Gln Ser Ser Leu His Ile Thr Ala Ser 
65                  70                  75                  80  


Gln Leu Ser Asp Ser Ala Ser Tyr Ile Cys Val Val Asn His Ala Gly 
                85                  90                  95      


Gly Ser Tyr Ile Pro Thr Phe Gly Arg Gly Thr Ser Leu Ile Val His 
            100                 105                 110         


Pro 
    


<210>  64
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant alpha chain (aS98L)

<400>  64

Ala Asn Gln Val Glu Gln Ser Pro Gln Ser Leu Ile Ile Leu Glu Gly 
1               5                   10                  15      


Lys Asn Val Thr Leu Gln Cys Asn Tyr Thr Val Ser Pro Phe Ser Asn 
            20                  25                  30          


Leu Arg Trp Tyr Lys Gln Asp Thr Gly Arg Gly Pro Val Ser Leu Thr 
        35                  40                  45              


Ile Met Thr Phe Ser Glu Asn Thr Lys Ser Asn Gly Arg Tyr Thr Ala 
    50                  55                  60                  


Thr Leu Asp Ala Asp Thr Lys Gln Ser Ser Leu His Ile Thr Ala Ser 
65                  70                  75                  80  


Gln Leu Ser Asp Ser Ala Ser Tyr Ile Cys Val Val Asn His Ser Gly 
                85                  90                  95      


Gly Leu Tyr Ile Pro Thr Phe Gly Arg Gly Thr Ser Leu Ile Val His 
            100                 105                 110         


Pro 
    


<210>  65
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant beta chain (b41)

<400>  65

Asp Val Lys Val Thr Gln Ser Ser Arg Tyr Leu Val Lys Arg Thr Gly 
1               5                   10                  15      


Glu Lys Val Phe Leu Glu Cys Val Gln Asp Met Asp His Glu Asn Met 
            20                  25                  30          


Phe Trp Tyr Arg Gln Asp Pro Gly Leu Gly Leu Arg Leu Ile Tyr Phe 
        35                  40                  45              


Ser Arg Phe Ala Thr Gly Lys Glu Lys Gly Asp Ile Pro Glu Gly Tyr 
    50                  55                  60                  


Ser Val Ser Arg Glu Lys Lys Glu Arg Phe Ser Leu Ile Leu Glu Ser 
65                  70                  75                  80  


Ala Ser Thr Asn Gln Thr Ser Met Tyr Leu Cys Ala Ser Ser Ser Asp 
                85                  90                  95      


Gln Asn Ser Gly Asp Pro Tyr Glu Gln Tyr Phe Gly Pro Gly Thr Arg 
            100                 105                 110         


Leu Thr Val Thr 
        115     


<210>  66
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant beta chain (b42)

<400>  66

Asp Val Lys Val Thr Gln Ser Ser Arg Tyr Leu Val Lys Arg Thr Gly 
1               5                   10                  15      


Glu Lys Val Phe Leu Glu Cys Val Gln Asp Leu Asp His Glu Asn Met 
            20                  25                  30          


Phe Trp Tyr Arg Gln Asp Pro Gly Leu Gly Leu Arg Leu Ile Tyr Phe 
        35                  40                  45              


Ser Tyr Phe Ala Thr Gly Lys Glu Lys Gly Asp Ile Pro Glu Gly Tyr 
    50                  55                  60                  


Ser Val Ser Arg Glu Lys Lys Glu Arg Phe Ser Leu Ile Leu Glu Ser 
65                  70                  75                  80  


Ala Ser Thr Asn Gln Thr Ser Met Tyr Leu Cys Ala Ser Ser Ser Asp 
                85                  90                  95      


Gln Asn Ser Gly Asp Pro Tyr Glu Gln Tyr Phe Gly Pro Gly Thr Arg 
            100                 105                 110         


Leu Thr Val Thr 
        115     


<210>  67
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant beta chain (b43)

<400>  67

Asp Val Lys Val Thr Gln Ser Ser Arg Tyr Leu Val Lys Arg Thr Gly 
1               5                   10                  15      


Glu Lys Val Phe Leu Glu Cys Val Gln Asp Leu Asp His Glu Asn Met 
            20                  25                  30          


Phe Trp Tyr Arg Gln Asp Pro Gly Leu Gly Leu Arg Leu Ile Tyr Phe 
        35                  40                  45              


Ser Arg Asp Ala Thr Gly Lys Glu Lys Gly Asp Ile Pro Glu Gly Tyr 
    50                  55                  60                  


Ser Val Ser Arg Glu Lys Lys Glu Arg Phe Ser Leu Ile Leu Glu Ser 
65                  70                  75                  80  


Ala Ser Thr Asn Gln Thr Ser Met Tyr Leu Cys Ala Ser Ser Ser Asp 
                85                  90                  95      


Gln Asn Ser Gly Asp Pro Tyr Glu Gln Tyr Phe Gly Pro Gly Thr Arg 
            100                 105                 110         


Leu Thr Val Thr 
        115     


<210>  68
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant beta chain (b44)

<400>  68

Asp Val Lys Val Thr Gln Ser Ser Arg Tyr Leu Val Lys Arg Thr Gly 
1               5                   10                  15      


Glu Lys Val Phe Leu Glu Cys Val Gln Asp Leu Asp His Glu Asn Met 
            20                  25                  30          


Phe Trp Tyr Arg Gln Asp Pro Gly Leu Gly Leu Arg Leu Ile Tyr Phe 
        35                  40                  45              


Ser Arg Phe Val Thr Gly Lys Glu Lys Gly Asp Ile Pro Glu Gly Tyr 
    50                  55                  60                  


Ser Val Ser Arg Glu Lys Lys Glu Arg Phe Ser Leu Ile Leu Glu Ser 
65                  70                  75                  80  


Ala Ser Thr Asn Gln Thr Ser Met Tyr Leu Cys Ala Ser Ser Ser Asp 
                85                  90                  95      


Gln Asn Ser Gly Asp Pro Tyr Glu Gln Tyr Phe Gly Pro Gly Thr Arg 
            100                 105                 110         


Leu Thr Val Thr 
        115     


<210>  69
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant beta chain (b45)

<400>  69

Asp Val Lys Val Thr Gln Ser Ser Arg Tyr Leu Val Lys Arg Thr Gly 
1               5                   10                  15      


Glu Lys Val Phe Leu Glu Cys Val Gln Asp Leu Asp His Glu Asn Met 
            20                  25                  30          


Phe Trp Tyr Arg Gln Asp Pro Gly Leu Gly Leu Arg Leu Ile Tyr Phe 
        35                  40                  45              


Ser Arg Phe Ala Lys Gly Lys Glu Lys Gly Asp Ile Pro Glu Gly Tyr 
    50                  55                  60                  


Ser Val Ser Arg Glu Lys Lys Glu Arg Phe Ser Leu Ile Leu Glu Ser 
65                  70                  75                  80  


Ala Ser Thr Asn Gln Thr Ser Met Tyr Leu Cys Ala Ser Ser Ser Asp 
                85                  90                  95      


Gln Asn Ser Gly Asp Pro Tyr Glu Gln Tyr Phe Gly Pro Gly Thr Arg 
            100                 105                 110         


Leu Thr Val Thr 
        115     


<210>  70
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant beta chain (b46)

<400>  70

Asp Val Lys Val Thr Gln Ser Ser Arg Tyr Leu Val Lys Arg Thr Gly 
1               5                   10                  15      


Glu Lys Val Phe Leu Glu Cys Val Gln Asp Leu Asp His Glu Asn Met 
            20                  25                  30          


Phe Trp Tyr Arg Gln Asp Pro Gly Leu Gly Leu Arg Leu Ile Tyr Phe 
        35                  40                  45              


Ser Arg Phe Ala Thr Met Lys Glu Lys Gly Asp Ile Pro Glu Gly Tyr 
    50                  55                  60                  


Ser Val Ser Arg Glu Lys Lys Glu Arg Phe Ser Leu Ile Leu Glu Ser 
65                  70                  75                  80  


Ala Ser Thr Asn Gln Thr Ser Met Tyr Leu Cys Ala Ser Ser Ser Asp 
                85                  90                  95      


Gln Asn Ser Gly Asp Pro Tyr Glu Gln Tyr Phe Gly Pro Gly Thr Arg 
            100                 105                 110         


Leu Thr Val Thr 
        115     


<210>  71
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant beta chain (b32)

<400>  71

Asp Val Lys Val Thr Gln Ser Ser Arg Tyr Leu Val Lys Arg Thr Gly 
1               5                   10                  15      


Glu Lys Val Phe Leu Glu Cys Val Gln Asp Met Pro Leu Ser Lys Met 
            20                  25                  30          


Phe Trp Tyr Arg Gln Asp Pro Gly Leu Gly Leu Arg Leu Ile Tyr Phe 
        35                  40                  45              


Ser Tyr Asp Val Lys Met Lys Glu Lys Gly Asp Ile Pro Glu Gly Tyr 
    50                  55                  60                  


Ser Val Ser Arg Glu Lys Lys Glu Arg Phe Ser Leu Ile Leu Glu Ser 
65                  70                  75                  80  


Ala Ser Thr Asn Gln Thr Ser Met Tyr Leu Cys Ala Ser Ser Ser Asp 
                85                  90                  95      


Gln Asn Ser Gly Asp Pro Tyr Glu Gln Tyr Phe Gly Pro Gly Thr Arg 
            100                 105                 110         


Leu Thr Val Thr 
        115     


<210>  72
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant beta chain (b33)

<400>  72

Asp Val Lys Val Thr Gln Ser Ser Arg Tyr Leu Val Lys Arg Thr Gly 
1               5                   10                  15      


Glu Lys Val Phe Leu Glu Cys Val Gln Asp Ala Asp Leu Ser Lys Met 
            20                  25                  30          


Phe Trp Tyr Arg Gln Asp Pro Gly Leu Gly Leu Arg Leu Ile Tyr Phe 
        35                  40                  45              


Ser Tyr Asp Val Lys Met Lys Glu Lys Gly Asp Ile Pro Glu Gly Tyr 
    50                  55                  60                  


Ser Val Ser Arg Glu Lys Lys Glu Arg Phe Ser Leu Ile Leu Glu Ser 
65                  70                  75                  80  


Ala Ser Thr Asn Gln Thr Ser Met Tyr Leu Cys Ala Ser Ser Ser Asp 
                85                  90                  95      


Gln Asn Ser Gly Asp Pro Tyr Glu Gln Tyr Phe Gly Pro Gly Thr Arg 
            100                 105                 110         


Leu Thr Val Thr 
        115     


<210>  73
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant beta chain (b34)

<400>  73

Asp Val Lys Val Thr Gln Ser Ser Arg Tyr Leu Val Lys Arg Thr Gly 
1               5                   10                  15      


Glu Lys Val Phe Leu Glu Cys Val Gln Asp Ala Pro His Ser Lys Met 
            20                  25                  30          


Phe Trp Tyr Arg Gln Asp Pro Gly Leu Gly Leu Arg Leu Ile Tyr Phe 
        35                  40                  45              


Ser Tyr Asp Val Lys Met Lys Glu Lys Gly Asp Ile Pro Glu Gly Tyr 
    50                  55                  60                  


Ser Val Ser Arg Glu Lys Lys Glu Arg Phe Ser Leu Ile Leu Glu Ser 
65                  70                  75                  80  


Ala Ser Thr Asn Gln Thr Ser Met Tyr Leu Cys Ala Ser Ser Ser Asp 
                85                  90                  95      


Gln Asn Ser Gly Asp Pro Tyr Glu Gln Tyr Phe Gly Pro Gly Thr Arg 
            100                 105                 110         


Leu Thr Val Thr 
        115     


<210>  74
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant beta chain (b35)

<400>  74

Asp Val Lys Val Thr Gln Ser Ser Arg Tyr Leu Val Lys Arg Thr Gly 
1               5                   10                  15      


Glu Lys Val Phe Leu Glu Cys Val Gln Asp Ala Pro Leu Glu Lys Met 
            20                  25                  30          


Phe Trp Tyr Arg Gln Asp Pro Gly Leu Gly Leu Arg Leu Ile Tyr Phe 
        35                  40                  45              


Ser Tyr Asp Val Lys Met Lys Glu Lys Gly Asp Ile Pro Glu Gly Tyr 
    50                  55                  60                  


Ser Val Ser Arg Glu Lys Lys Glu Arg Phe Ser Leu Ile Leu Glu Ser 
65                  70                  75                  80  


Ala Ser Thr Asn Gln Thr Ser Met Tyr Leu Cys Ala Ser Ser Ser Asp 
                85                  90                  95      


Gln Asn Ser Gly Asp Pro Tyr Glu Gln Tyr Phe Gly Pro Gly Thr Arg 
            100                 105                 110         


Leu Thr Val Thr 
        115     


<210>  75
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant beta chain (b36)

<400>  75

Asp Val Lys Val Thr Gln Ser Ser Arg Tyr Leu Val Lys Arg Thr Gly 
1               5                   10                  15      


Glu Lys Val Phe Leu Glu Cys Val Gln Asp Ala Pro Leu Ser Asn Met 
            20                  25                  30          


Phe Trp Tyr Arg Gln Asp Pro Gly Leu Gly Leu Arg Leu Ile Tyr Phe 
        35                  40                  45              


Ser Tyr Asp Val Lys Met Lys Glu Lys Gly Asp Ile Pro Glu Gly Tyr 
    50                  55                  60                  


Ser Val Ser Arg Glu Lys Lys Glu Arg Phe Ser Leu Ile Leu Glu Ser 
65                  70                  75                  80  


Ala Ser Thr Asn Gln Thr Ser Met Tyr Leu Cys Ala Ser Ser Ser Asp 
                85                  90                  95      


Gln Asn Ser Gly Asp Pro Tyr Glu Gln Tyr Phe Gly Pro Gly Thr Arg 
            100                 105                 110         


Leu Thr Val Thr 
        115     


<210>  76
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant beta chain (b37)

<400>  76

Asp Val Lys Val Thr Gln Ser Ser Arg Tyr Leu Val Lys Arg Thr Gly 
1               5                   10                  15      


Glu Lys Val Phe Leu Glu Cys Val Gln Asp Ala Pro Leu Ser Lys Met 
            20                  25                  30          


Phe Trp Tyr Arg Gln Asp Pro Gly Leu Gly Leu Arg Leu Ile Tyr Phe 
        35                  40                  45              


Ser Tyr Asp Val Lys Met Lys Glu Lys Gly Asp Ile Pro Glu Gly Tyr 
    50                  55                  60                  


Ser Val Ser Arg Glu Lys Lys Glu Arg Phe Ser Leu Ile Leu Glu Ser 
65                  70                  75                  80  


Ala Ser Thr Asn Gln Thr Ser Met Tyr Leu Cys Ala Ser Ser Phe Asp 
                85                  90                  95      


Gln Asn Ser Gly Asp Pro Tyr Glu Gln Tyr Phe Gly Pro Gly Thr Arg 
            100                 105                 110         


Leu Thr Val Thr 
        115     


<210>  77
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant beta chain (b38)

<400>  77

Asp Val Lys Val Thr Gln Ser Ser Arg Tyr Leu Val Lys Arg Thr Gly 
1               5                   10                  15      


Glu Lys Val Phe Leu Glu Cys Val Gln Asp Ala Pro Leu Ser Lys Met 
            20                  25                  30          


Phe Trp Tyr Arg Gln Asp Pro Gly Leu Gly Leu Arg Leu Ile Tyr Phe 
        35                  40                  45              


Ser Tyr Asp Val Lys Met Lys Glu Lys Gly Asp Ile Pro Glu Gly Tyr 
    50                  55                  60                  


Ser Val Ser Arg Glu Lys Lys Glu Arg Phe Ser Leu Ile Leu Glu Ser 
65                  70                  75                  80  


Ala Ser Thr Asn Gln Thr Ser Met Tyr Leu Cys Ala Ser Ser Ser Leu 
                85                  90                  95      


Gln Asn Ser Gly Asp Pro Tyr Glu Gln Tyr Phe Gly Pro Gly Thr Arg 
            100                 105                 110         


Leu Thr Val Thr 
        115     


<210>  78
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant beta chain (b39)

<400>  78

Asp Val Lys Val Thr Gln Ser Ser Arg Tyr Leu Val Lys Arg Thr Gly 
1               5                   10                  15      


Glu Lys Val Phe Leu Glu Cys Val Gln Asp Ala Pro Leu Ser Lys Met 
            20                  25                  30          


Phe Trp Tyr Arg Gln Asp Pro Gly Leu Gly Leu Arg Leu Ile Tyr Phe 
        35                  40                  45              


Ser Tyr Asp Val Lys Met Lys Glu Lys Gly Asp Ile Pro Glu Gly Tyr 
    50                  55                  60                  


Ser Val Ser Arg Glu Lys Lys Glu Arg Phe Ser Leu Ile Leu Glu Ser 
65                  70                  75                  80  


Ala Ser Thr Asn Gln Thr Ser Met Tyr Leu Cys Ala Ser Ser Ser Asp 
                85                  90                  95      


Met Asn Ser Gly Asp Pro Tyr Glu Gln Tyr Phe Gly Pro Gly Thr Arg 
            100                 105                 110         


Leu Thr Val Thr 
        115     


<210>  79
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant beta chain (b40)

<400>  79

Asp Val Lys Val Thr Gln Ser Ser Arg Tyr Leu Val Lys Arg Thr Gly 
1               5                   10                  15      


Glu Lys Val Phe Leu Glu Cys Val Gln Asp Ala Pro Leu Ser Lys Met 
            20                  25                  30          


Phe Trp Tyr Arg Gln Asp Pro Gly Leu Gly Leu Arg Leu Ile Tyr Phe 
        35                  40                  45              


Ser Tyr Asp Val Lys Met Lys Glu Lys Gly Asp Ile Pro Glu Gly Tyr 
    50                  55                  60                  


Ser Val Ser Arg Glu Lys Lys Glu Arg Phe Ser Leu Ile Leu Glu Ser 
65                  70                  75                  80  


Ala Ser Thr Asn Gln Thr Ser Met Tyr Leu Cys Ala Ser Ser Ser Asp 
                85                  90                  95      


Gln Thr Ser Gly Asp Pro Tyr Glu Gln Tyr Phe Gly Pro Gly Thr Arg 
            100                 105                 110         


Leu Thr Val Thr 
        115     


<210>  80
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant beta chain (bL96D)

<400>  80

Asp Val Lys Val Thr Gln Ser Ser Arg Tyr Leu Val Lys Arg Thr Gly 
1               5                   10                  15      


Glu Lys Val Phe Leu Glu Cys Val Gln Asp Met Asp His Glu Asn Met 
            20                  25                  30          


Phe Trp Tyr Arg Gln Asp Pro Gly Leu Gly Leu Arg Leu Ile Tyr Phe 
        35                  40                  45              


Ser Tyr Asp Val Lys Met Lys Glu Lys Gly Asp Ile Pro Glu Gly Tyr 
    50                  55                  60                  


Ser Val Ser Arg Glu Lys Lys Glu Arg Phe Ser Leu Ile Leu Glu Ser 
65                  70                  75                  80  


Ala Ser Thr Asn Gln Thr Ser Met Tyr Leu Cys Ala Ser Ser Phe Asp 
                85                  90                  95      


Met Thr Ser Gly Asp Pro Tyr Glu Gln Tyr Phe Gly Pro Gly Thr Arg 
            100                 105                 110         


Leu Thr Val Thr 
        115     


<210>  81
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant beta chain (bM97Q)

<400>  81

Asp Val Lys Val Thr Gln Ser Ser Arg Tyr Leu Val Lys Arg Thr Gly 
1               5                   10                  15      


Glu Lys Val Phe Leu Glu Cys Val Gln Asp Met Asp His Glu Asn Met 
            20                  25                  30          


Phe Trp Tyr Arg Gln Asp Pro Gly Leu Gly Leu Arg Leu Ile Tyr Phe 
        35                  40                  45              


Ser Tyr Asp Val Lys Met Lys Glu Lys Gly Asp Ile Pro Glu Gly Tyr 
    50                  55                  60                  


Ser Val Ser Arg Glu Lys Lys Glu Arg Phe Ser Leu Ile Leu Glu Ser 
65                  70                  75                  80  


Ala Ser Thr Asn Gln Thr Ser Met Tyr Leu Cys Ala Ser Ser Phe Leu 
                85                  90                  95      


Gln Thr Ser Gly Asp Pro Tyr Glu Gln Tyr Phe Gly Pro Gly Thr Arg 
            100                 105                 110         


Leu Thr Val Thr 
        115     


