                         SEQUENCE LISTING

<110>  The General Hospital Corporation
 
<120>  PARATHYROID HORMONE RECEPTOR 1 ANTAGONIST AND INVERSE AGONIST 
       POLYPEPTIDES AND METHODS OF THEIR USE

<130>  00786-576WO2

<150>  US 62/317,152
<151>  2016-04-01

<160>  20    

<170>  PatentIn version 3.5

<210>  1
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  1

Ile Gln Leu Met His Gln Arg Ala Lys Trp Ile Gln Asp Ala Arg Arg 
1               5                   10                  15      


Arg Ala Phe Leu His Lys Leu Ile Ala Glu Ile His Thr Ala Glu Ile 
            20                  25                  30          


<210>  2
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa is d-tryptophan

<400>  2

Ile Gln Leu Met His Gln Arg Xaa Lys Trp Ile Gln Asp Ala Arg Arg 
1               5                   10                  15      


Arg Ala Trp Leu His Lys Leu Ile Ala Glu Ile His Thr Ala Glu Ile 
            20                  25                  30          


<210>  3
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is norleucine

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa is d-tryptophan

<400>  3

Ile Gln Leu Xaa His Gln Arg Xaa Lys Trp Ile Gln Asp Ala Arg Arg 
1               5                   10                  15      


Arg Ala Trp Leu His Lys Leu Ile Ala Glu Ile His Thr Ala Glu Tyr 
            20                  25                  30          


<210>  4
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is norleucine

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa is d-tryptophan

<400>  4

Ile Gln Leu Xaa His Gln Arg Xaa Lys Trp Ile Gln Asp Ala Arg Arg 
1               5                   10                  15      


Arg Ala Trp Leu His Lys Leu Ile Ala Glu Ile His Thr Ala Glu Cys 
            20                  25                  30          


<210>  5
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is norleucine

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa is d-tryptophan

<400>  5

Ile Gln Leu Xaa His Gln Arg Xaa Lys Trp Ile Gln Asp Ala Arg Arg 
1               5                   10                  15      


Arg Ala Trp Leu His Lys Leu Ile Ala Glu Ile His Thr Ala Glu Ile 
            20                  25                  30          


Cys 
    


<210>  6
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa is d-tryptophan

<400>  6

Ile Gln Leu Met His Gln Arg Xaa Lys Trp Ile Gln Asp Ala Arg Arg 
1               5                   10                  15      


Arg Ala Trp Leu His Lys Leu Ile Ala Glu Ile His Thr Ala Glu Ile 
            20                  25                  30          


Cys 
    


<210>  7
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is d-tryptophan

<400>  7

Phe Met His Asn Leu Xaa Lys His Leu Ser Ser Met Glu Arg Val Glu 
1               5                   10                  15      


Trp Leu Arg Lys Lys Leu Gln Asp Val His Asn Tyr 
            20                  25              


<210>  8
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is norleucine

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is d-tryptophan

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa is norleucine

<400>  8

Phe Xaa His Asn Leu Xaa Lys His Leu Ser Ser Xaa Glu Arg Val Glu 
1               5                   10                  15      


Trp Leu Arg Lys Lys Leu Gln Asp Val His Asn Tyr 
            20                  25              


<210>  9
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is norleucine

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is d-tryptophan

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa is norleucine

<400>  9

Phe Xaa His Asn Leu Xaa Lys His Leu Ser Ser Xaa Glu Arg Val Glu 
1               5                   10                  15      


Trp Leu Arg Lys Lys Leu Gln Asp Val His Asn Phe Cys 
            20                  25                  


<210>  10
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  10

Ser Val Ser Glu Ile Gln Leu Met His Asn Leu Gly Lys His Leu Asn 
1               5                   10                  15      


Ser Met Glu Arg Val Glu Trp Leu Arg Lys Lys Leu Gln Asp Val His 
            20                  25                  30          


Asn Phe 
        


<210>  11
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  11

Ala Val Ser Glu His Gln Leu Leu His Asp Lys Gly Lys Ser Ile Gln 
1               5                   10                  15      


Asp Leu Arg Arg Arg Phe Phe Leu His His Leu Ile Ala Glu Ile His 
            20                  25                  30          


Thr Ala Glu Ile 
        35      


<210>  12
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is 1 aminocyclopentane-1-carboxylic acid

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is alpha-aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa is homoarginine

<400>  12

Xaa Val Xaa Glu Ile Gln Leu Met His Gln Xaa 
1               5                   10      


<210>  13
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  13

Ser Val Ser Glu Ile Gln Leu Met His Asn Leu Gly Lys His Leu Asn 
1               5                   10                  15      


Ser Met Glu Arg Val Glu Trp Leu Arg Lys Lys Leu Gln Asp Val His 
            20                  25                  30          


Asn Phe Cys 
        35  


<210>  14
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is d-tryptophan

<400>  14

Leu Met His Gln Arg Xaa Lys Trp Ile Gln Asp Ala Arg Arg Arg Ala 
1               5                   10                  15      


Trp Leu His Lys Leu Ile Ala Glu Ile His Thr Ala Glu Ile 
            20                  25                  30  


<210>  15
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is norleucine

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is d-tryptophan

<400>  15

Leu Xaa His Gln Arg Xaa Lys Trp Ile Gln Asp Ala Arg Arg Arg Ala 
1               5                   10                  15      


Trp Leu His Lys Leu Ile Ala Glu Ile His Thr Ala Glu Ile 
            20                  25                  30  


<210>  16
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is norleucine

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is d-tryptophan

<400>  16

Leu Xaa His Gln Leu Xaa Lys Trp Ile Gln Asp Ala Arg Arg Arg Ala 
1               5                   10                  15      


Trp Leu His Lys Leu Ile Ala Glu Ile His Thr Ala Glu Ile 
            20                  25                  30  


<210>  17
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is norleucine

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa is d-tryptophan

<400>  17

Ile Gln Leu Xaa His Gln Leu Xaa Lys Trp Ile Gln Asp Ala Arg Arg 
1               5                   10                  15      


Arg Ala Trp Leu His Lys Leu Ile Ala Glu Ile His Thr Ala Glu Ile 
            20                  25                  30          


<210>  18
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is d-tryptophan

<400>  18

Leu Met His Gln Leu Xaa Lys Trp Ile Gln Asp Ala Arg Arg Arg Ala 
1               5                   10                  15      


Trp Leu His Lys Leu Ile Ala Glu Ile His Thr Ala Glu Ile 
            20                  25                  30  


<210>  19
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa is d-tryptophan

<400>  19

Ile Gln Leu Met His Gln Leu Xaa Lys Trp Ile Gln Asp Ala Arg Arg 
1               5                   10                  15      


Arg Ala Trp Leu His Lys Leu Ile Ala Glu Ile His Thr Ala Glu Ile 
            20                  25                  30          


<210>  20
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is d-tryptophan

<400>  20

Leu Leu His Asp Leu Xaa Lys Ser Ile Gln Asp Leu Arg Arg Arg Phe 
1               5                   10                  15      


Trp Leu His His Leu Ile Ala Glu Ile His Thr Ala Glu Tyr 
            20                  25                  30  


