                         SEQUENCE LISTING

<110>  THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE 
       SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
       IHSAN  DOGRAMACI BILKENT UNIVERSITY
 
<120>  EXTRACELLULAR VESICLES, METHODS OF MAKING THEM, AND METHODS OF

<130>  077867-1044125

<150>  US 62/316,276
<151>  2016-03-31

<160>  25    

<170>  PatentIn version 3.5

<210>  1
<211>  3761
<212>  DNA
<213>  Homo sapiens

<400>  1
aaatttagat tttgcaaacc tgtgcattga tgagagtgct attgaaacac attaagaaag       60

attttcaacg caggaatgtg tcatttcctt tcttcatgta ccagatgctg aaatactatg      120

agataaagat tttaggtttc aattgtaaag agagagaagt ggataaatca gtgctgcttt      180

ctttaggacg aaagaagtat ggagcagtgg gatcactttc acaatcaaca ggaggacact      240

gatagctgct ccgaatctgt gaaatttgat gctcgctcaa tgacagcttt gcttcctccg      300

aatcctaaaa acagcccttc ccttcaagag aaactgaagt ccttcaaagc tgcactgatt      360

gccctttacc tcctcgtgtt tgcagttctc atccctctca ttggaatagt ggcagctcaa      420

ctcctgaagt gggaaacgaa gaattgctca gttagttcaa ctaatgcaaa tgatataact      480

caaagtctca cgggaaaagg aaatgacagc gaagaggaaa tgagatttca agaagtcttt      540

atggaacaca tgagcaacat ggagaagaga atccagcata ttttagacat ggaagccaac      600

ctcatggaca cagagcattt ccaaaatttc agcatgacaa ctgatcaaag atttaatgac      660

attcttctgc agctaagtac cttgttttcc tcagtccagg gacatgggaa tgcaatagat      720

gaaatctcca agtccttaat aagtttgaat accacattgc ttgatttgca gctcaacata      780

gaaaatctga atggcaaaat ccaagagaat accttcaaac aacaagagga aatcagtaaa      840

ttagaggagc gtgtttacaa tgtatcagca gaaattatgg ctatgaaaga agaacaagtg      900

catttggaac aggaaataaa aggagaagtg aaagtactga ataacatcac taatgatctc      960

agactgaaag attgggaaca ttctcagacc ttgagaaata tcactttaat tcaaggtcct     1020

cctggacccc cgggtgaaaa aggagatcga ggtcccactg gagaaagtgg tccacgagga     1080

tttccaggtc caataggtcc tccgggtctt aaaggtgatc ggggagcaat tggctttcct     1140

ggaagtcgag gactcccagg atatgccgga aggccaggaa attctggacc aaaaggccag     1200

aaaggggaaa aggggagtgg aaacacatta actccattta cgaaagttcg actggtcggt     1260

gggagcggcc ctcacgaggg gagggtggag atactccaca gcggccagtg gggtacaatt     1320

tgtgacgatc gctgggaagt gcgcgttgga caggtcgtct gtaggagctt gggataccca     1380

ggtgttcaag ccgtgcacaa ggcagctcac tttggacaag gtactggtcc aatatggctg     1440

aatgaagtgt tttgttttgg gagagaatca tctattgaag aatgtaaaat tcggcaatgg     1500

gggacaagag cctgttcaca ttctgaagat gctggagtca cttgcacttt ataatgcatc     1560

atattttcat tcacaactat gaaatcgctg ctcaaaaatg attttattac cttgttcctg     1620

taaaatccat ttaatcaata tttaagagat taagaatatt gcccaaataa tattttagat     1680

tacaggatta atatattgaa caccttcatg cttactattt tatgtctata tttaaatcat     1740

tttaacttct ataggttttt aaatggaatt ttctaatata atgacttata tgctgaattg     1800

aacattttga agtttatagc ttccagatta caaaggccaa gggtaataga aatgcatacc     1860

agtaattggc tccaattcat aatatgttca ccaggagatt acaatttttt gctcttcttg     1920

tctttgtaat ctatttagtt gattttaatt actttctgaa taacggaagg gatcagaaga     1980

tatcttttgt gcctagattg caaaatctcc aatccacaca tattgtttta aaataagaat     2040

gttatccaac tattaagata tctcaatgtg caataacttg tgtattagat atcaatgtta     2100

atgatatgtc ttggccacta tggaccaggg agcttatttt tcttgtcatg tactgacaac     2160

tgtttaattg aatcatgaag taaattgaaa gcaggacata tgagaaaact gaccatcagt     2220

atatttgtcc agataattgg tggatcaaaa atgccactta acaggaagtt tagtttgtta     2280

tgcactttaa atggaataat tagcttgtta caattctagg acatggtgtt taaaatttaa     2340

atctgattaa tccattttaa caaacaatgc aaacatcttc agtgcagaag gaagagtggt     2400

ttcaactgtt tggagtcttt tatgaagtca gtcaacattt acaaccaaag ggcggggggg     2460

ggggtggggg gtgcgtcttt agtcctaaag ggacaataac tctgagcatg ccccaaaaaa     2520

gtagtttagc aaccttttgt tggtagtcaa cccatcccca gggccatagt gtagagtgtg     2580

aaaagctacc ctgaaaccca gtaattctac cctgaaagtg actgcctgca gaaagaccag     2640

cagttgatat taaagcgcaa atgaattcaa cctcagccct gaaaataaca gaattctgaa     2700

gtttcctatg actaattcac aaaaaaagta attgtaaact agtactatta tggaattact     2760

ctactgttct ttctttaata gtggcaaatg aaagcataag cttaagcatt ttttcatatt     2820

ctgaagtctc accacacata ataaccaagt ggtagactca cagccgtcca acttaaaaag     2880

gcaaaacctt accttggaat tggaattact gtaaacagcc tactgaaaat gcatttttat     2940

catgtaacat tcttctactt gtttaacatt gctgattttc tctggcagca taattttgtg     3000

gttaagagaa tgaattctga atgtacactt tctgtctcaa accctggctg taatttcagc     3060

tagttaataa ttctttgtgt tcagttccac tatctaggta ttttcttcaa aaggtaaata     3120

caatggtttc tgaaagaatc atttgcatta tcagcctgtt tgggatgtct gagatcagtg     3180

cctctgggtt gttaatactg tattgctgta tggtatatgt atgctgattt actacttatg     3240

cgtaagtggt atgcatggga tgtctgaaat cagtgcctat gggttgtcaa tagtattaac     3300

tattagtgtt aactgttagt attaactatt agtattatta acactaataa tagtactatt     3360

actattacta tttttatttt aaaataaaat ttacctttaa aataataata gtactattgc     3420

tagtactagt actattgcta ttactagtac tattactagt actagtacta tgacactgtt     3480

aatagtacta ttaacaaccc ataggcactt gggatgtctg agatcagtgc ctatgggttg     3540

ttaatactat attgctgtat ggtatatgca tgctgattta ccacttatgc atagatatat     3600

ctttaataag taatctaaaa atcctttttg tatttgagag aatctactaa gttcagtcca     3660

gtcaagaaaa gaacctaata gcaccaatac aaattgagga cttaatttac tttggaatgt     3720

tgaattgcat ttgttccatt aaaaaaaaca gaaatttgcg a                         3761


<210>  2
<211>  451
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Glu Gln Trp Asp His Phe His Asn Gln Gln Glu Asp Thr Asp Ser 
1               5                   10                  15      


Cys Ser Glu Ser Val Lys Phe Asp Ala Arg Ser Met Thr Ala Leu Leu 
            20                  25                  30          


Pro Pro Asn Pro Lys Asn Ser Pro Ser Leu Gln Glu Lys Leu Lys Ser 
        35                  40                  45              


Phe Lys Ala Ala Leu Ile Ala Leu Tyr Leu Leu Val Phe Ala Val Leu 
    50                  55                  60                  


Ile Pro Leu Ile Gly Ile Val Ala Ala Gln Leu Leu Lys Trp Glu Thr 
65                  70                  75                  80  


Lys Asn Cys Ser Val Ser Ser Thr Asn Ala Asn Asp Ile Thr Gln Ser 
                85                  90                  95      


Leu Thr Gly Lys Gly Asn Asp Ser Glu Glu Glu Met Arg Phe Gln Glu 
            100                 105                 110         


Val Phe Met Glu His Met Ser Asn Met Glu Lys Arg Ile Gln His Ile 
        115                 120                 125             


Leu Asp Met Glu Ala Asn Leu Met Asp Thr Glu His Phe Gln Asn Phe 
    130                 135                 140                 


Ser Met Thr Thr Asp Gln Arg Phe Asn Asp Ile Leu Leu Gln Leu Ser 
145                 150                 155                 160 


Thr Leu Phe Ser Ser Val Gln Gly His Gly Asn Ala Ile Asp Glu Ile 
                165                 170                 175     


Ser Lys Ser Leu Ile Ser Leu Asn Thr Thr Leu Leu Asp Leu Gln Leu 
            180                 185                 190         


Asn Ile Glu Asn Leu Asn Gly Lys Ile Gln Glu Asn Thr Phe Lys Gln 
        195                 200                 205             


Gln Glu Glu Ile Ser Lys Leu Glu Glu Arg Val Tyr Asn Val Ser Ala 
    210                 215                 220                 


Glu Ile Met Ala Met Lys Glu Glu Gln Val His Leu Glu Gln Glu Ile 
225                 230                 235                 240 


Lys Gly Glu Val Lys Val Leu Asn Asn Ile Thr Asn Asp Leu Arg Leu 
                245                 250                 255     


Lys Asp Trp Glu His Ser Gln Thr Leu Arg Asn Ile Thr Leu Ile Gln 
            260                 265                 270         


Gly Pro Pro Gly Pro Pro Gly Glu Lys Gly Asp Arg Gly Pro Thr Gly 
        275                 280                 285             


Glu Ser Gly Pro Arg Gly Phe Pro Gly Pro Ile Gly Pro Pro Gly Leu 
    290                 295                 300                 


Lys Gly Asp Arg Gly Ala Ile Gly Phe Pro Gly Ser Arg Gly Leu Pro 
305                 310                 315                 320 


Gly Tyr Ala Gly Arg Pro Gly Asn Ser Gly Pro Lys Gly Gln Lys Gly 
                325                 330                 335     


Glu Lys Gly Ser Gly Asn Thr Leu Thr Pro Phe Thr Lys Val Arg Leu 
            340                 345                 350         


Val Gly Gly Ser Gly Pro His Glu Gly Arg Val Glu Ile Leu His Ser 
        355                 360                 365             


Gly Gln Trp Gly Thr Ile Cys Asp Asp Arg Trp Glu Val Arg Val Gly 
    370                 375                 380                 


Gln Val Val Cys Arg Ser Leu Gly Tyr Pro Gly Val Gln Ala Val His 
385                 390                 395                 400 


Lys Ala Ala His Phe Gly Gln Gly Thr Gly Pro Ile Trp Leu Asn Glu 
                405                 410                 415     


Val Phe Cys Phe Gly Arg Glu Ser Ser Ile Glu Glu Cys Lys Ile Arg 
            420                 425                 430         


Gln Trp Gly Thr Arg Ala Cys Ser His Ser Glu Asp Ala Gly Val Thr 
        435                 440                 445             


Cys Thr Leu 
    450     


<210>  3
<211>  2960
<212>  DNA
<213>  Homo sapiens

<400>  3
aaatttagat tttgcaaacc tgtgcattga tgagagtgct attgaaacac attaagaaag       60

attttcaacg caggaatgtg tcatttcctt tcttcatgta ccagatgctg aaatactatg      120

agataaagat tttaggtttc aattgtaaag agagagaagt ggataaatca gtgctgcttt      180

ctttaggacg aaagaagtat ggagcagtgg gatcactttc acaatcaaca ggaggacact      240

gatagctgct ccgaatctgt gaaatttgat gctcgctcaa tgacagcttt gcttcctccg      300

aatcctaaaa acagcccttc ccttcaagag aaactgaagt ccttcaaagc tgcactgatt      360

gccctttacc tcctcgtgtt tgcagttctc atccctctca ttggaatagt ggcagctcaa      420

ctcctgaagt gggaaacgaa gaattgctca gttagttcaa ctaatgcaaa tgatataact      480

caaagtctca cgggaaaagg aaatgacagc gaagaggaaa tgagatttca agaagtcttt      540

atggaacaca tgagcaacat ggagaagaga atccagcata ttttagacat ggaagccaac      600

ctcatggaca cagagcattt ccaaaatttc agcatgacaa ctgatcaaag atttaatgac      660

attcttctgc agctaagtac cttgttttcc tcagtccagg gacatgggaa tgcaatagat      720

gaaatctcca agtccttaat aagtttgaat accacattgc ttgatttgca gctcaacata      780

gaaaatctga atggcaaaat ccaagagaat accttcaaac aacaagagga aatcagtaaa      840

ttagaggagc gtgtttacaa tgtatcagca gaaattatgg ctatgaaaga agaacaagtg      900

catttggaac aggaaataaa aggagaagtg aaagtactga ataacatcac taatgatctc      960

agactgaaag attgggaaca ttctcagacc ttgagaaata tcactttaat tcaaggtcct     1020

cctggacccc cgggtgaaaa aggagatcga ggtcccactg gagaaagtgg tccacgagga     1080

tttccaggtc caataggtcc tccgggtctt aaaggtgatc ggggagcaat tggctttcct     1140

ggaagtcgag gactcccagg atatgccgga aggccaggaa attctggacc aaaaggccag     1200

aaaggggaaa aggggagtgg aaacacatta agaccagtac aactcactga tcatattagg     1260

gcagggccct cttaagatca ggtgggttgg gcgggacatc ctctgctacc atctcattaa     1320

aaggcccttc acctctggac aagtcatctg cacaactgac ttccaagatc cttttgtgac     1380

tcctccaaat gactttggtt cccgtgttgt acctgacttc cacatggcct tctctcctgg     1440

tccctggtgc tgtttgggcc tctgctccca tgctcatacc tcttcttact ccaattactc     1500

caccatcacc tctctcccct atcaccccca gcctggacac ctctcatgca cggactggag     1560

ggctgctcca accagtcctc agttctctgc cacccattga cctagagtct tgaacccaat     1620

ttaatttatt gggttctagg agaactgctg tgttctcacc ctaacttgga agagtgatgt     1680

ttcagtcaag caaagcgatt cctaccatac aatataacac ttgtgtgagg ctctgtccta     1740

aatatctcaa ttaccaatat gtggtttggt agtatttctc gccatgcttt gctcatgcgc     1800

aatgagacta caactagggt gtaaatttta agtatcccat ctaaaactca tacaatgata     1860

ggaaaaatcc atttgttttt catttgattt ttactgagga atcagctcaa tcttcaatga     1920

atactggtct ctttccaaag catttttgat caaagtaaag actgagtcaa gggctttttt     1980

tttttctttt tcttgtttta agagacagag ccttgttcta ttgcacaggc tggactacac     2040

gcattcacct agagtctaga acacaattta atttattggg ttctaggaga actgtcatga     2100

gtattgataa tatgagagtt ctttatattc aaacattatt ctcaaccaga gatagggatg     2160

tcatagaaga aaatccattc attcaatcat taattcacat gtccattatg tacctccatg     2220

agctggacat aacagctaat aagagataat tgtctctggt tttacagagc taattgtccc     2280

taagagatgt agacaaatga acaagcaatt acaatacatc taagctatac tgggggagga     2340

acagggctgg ataggtatgc agaggagata aaaaaatttt aattccttag aatatttttt     2400

aaaaattgat tcttatttta ccttctcatc ttcttatttt ccaaattaca gcatatatat     2460

atatatatat atatatatat atatatatat atatatatat attttttttt tttttttttt     2520

ttttttttta agttttgaag tgtagtcgag cttgggcaat ttatccaacc catttaaacc     2580

aaaaataaaa cttttcatgt attacctggt catttcaaac aaaaatattt tgatcatgaa     2640

aaagaatacc aatattcttt tgttctaaaa atctcttatg ggattacatg ttatattttt     2700

ggtttctctc tactgatcaa cagactacat tttcacaact cttctttcct ttacgtttta     2760

acacacagac ccaagattca tactattaag attctagtag aactctagat ggtatgcctc     2820

tgtgtatctc agcattttta ttcccactct tgtataatga acatgttaac acctacctca     2880

cagggttgtt gtgaggatca agtaagatat tgtgtgtgtg aagatgctct gtgaaatcat     2940

aaagtccttt aaagatgtaa                                                 2960


<210>  4
<211>  358
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Glu Gln Trp Asp His Phe His Asn Gln Gln Glu Asp Thr Asp Ser 
1               5                   10                  15      


Cys Ser Glu Ser Val Lys Phe Asp Ala Arg Ser Met Thr Ala Leu Leu 
            20                  25                  30          


Pro Pro Asn Pro Lys Asn Ser Pro Ser Leu Gln Glu Lys Leu Lys Ser 
        35                  40                  45              


Phe Lys Ala Ala Leu Ile Ala Leu Tyr Leu Leu Val Phe Ala Val Leu 
    50                  55                  60                  


Ile Pro Leu Ile Gly Ile Val Ala Ala Gln Leu Leu Lys Trp Glu Thr 
65                  70                  75                  80  


Lys Asn Cys Ser Val Ser Ser Thr Asn Ala Asn Asp Ile Thr Gln Ser 
                85                  90                  95      


Leu Thr Gly Lys Gly Asn Asp Ser Glu Glu Glu Met Arg Phe Gln Glu 
            100                 105                 110         


Val Phe Met Glu His Met Ser Asn Met Glu Lys Arg Ile Gln His Ile 
        115                 120                 125             


Leu Asp Met Glu Ala Asn Leu Met Asp Thr Glu His Phe Gln Asn Phe 
    130                 135                 140                 


Ser Met Thr Thr Asp Gln Arg Phe Asn Asp Ile Leu Leu Gln Leu Ser 
145                 150                 155                 160 


Thr Leu Phe Ser Ser Val Gln Gly His Gly Asn Ala Ile Asp Glu Ile 
                165                 170                 175     


Ser Lys Ser Leu Ile Ser Leu Asn Thr Thr Leu Leu Asp Leu Gln Leu 
            180                 185                 190         


Asn Ile Glu Asn Leu Asn Gly Lys Ile Gln Glu Asn Thr Phe Lys Gln 
        195                 200                 205             


Gln Glu Glu Ile Ser Lys Leu Glu Glu Arg Val Tyr Asn Val Ser Ala 
    210                 215                 220                 


Glu Ile Met Ala Met Lys Glu Glu Gln Val His Leu Glu Gln Glu Ile 
225                 230                 235                 240 


Lys Gly Glu Val Lys Val Leu Asn Asn Ile Thr Asn Asp Leu Arg Leu 
                245                 250                 255     


Lys Asp Trp Glu His Ser Gln Thr Leu Arg Asn Ile Thr Leu Ile Gln 
            260                 265                 270         


Gly Pro Pro Gly Pro Pro Gly Glu Lys Gly Asp Arg Gly Pro Thr Gly 
        275                 280                 285             


Glu Ser Gly Pro Arg Gly Phe Pro Gly Pro Ile Gly Pro Pro Gly Leu 
    290                 295                 300                 


Lys Gly Asp Arg Gly Ala Ile Gly Phe Pro Gly Ser Arg Gly Leu Pro 
305                 310                 315                 320 


Gly Tyr Ala Gly Arg Pro Gly Asn Ser Gly Pro Lys Gly Gln Lys Gly 
                325                 330                 335     


Glu Lys Gly Ser Gly Asn Thr Leu Arg Pro Val Gln Leu Thr Asp His 
            340                 345                 350         


Ile Arg Ala Gly Pro Ser 
        355             


<210>  5
<211>  3572
<212>  DNA
<213>  Homo sapiens

<400>  5
aaatttagat tttgcaaacc tgtgcattga tgagagtgct attgaaacac attaagaaag       60

attttcaacg caggaatgtg tcatttcctt tcttcatgta ccagatgctg aaatactatg      120

agataaagat tttaggtttc aattgtaaag agagagaagt ggataaatca gtgctgcttt      180

ctttaggacg aaagaagtat ggagcagtgg gatcactttc acaatcaaca ggaggacact      240

gatagctgct ccgaatctgt gaaatttgat gctcgctcaa tgacagcttt gcttcctccg      300

aatcctaaaa acagcccttc ccttcaagag aaactgaagt ccttcaaagc tgcactgatt      360

gccctttacc tcctcgtgtt tgcagttctc atccctctca ttggaatagt ggcagctcaa      420

ctcctgaagt gggaaacgaa gaattgctca gttagttcaa ctaatgcaaa tgatataact      480

caaagtctca cgggaaaagg aaatgacagc gaagaggaaa tgagatttca agaagtcttt      540

atggaacaca tgagcaacat ggagaagaga atccagcata ttttagacat ggaagccaac      600

ctcatggaca cagagcattt ccaaaatttc agcatgacaa ctgatcaaag atttaatgac      660

attcttctgc agctaagtac cttgttttcc tcagtccagg gacatgggaa tgcaatagat      720

gaaatctcca agtccttaat aagtttgaat accacattgc ttgatttgca gctcaacata      780

gaaaatctga atggcaaaat ccaagagaat accttcaaac aacaagagga aatcagtaaa      840

ttagaggagc gtgtttacaa tgtatcagca gaaattatgg ctatgaaaga agaacaagtg      900

catttggaac aggaaataaa aggagaagtg aaagtactga ataacatcac taatgatctc      960

agactgaaag attgggaaca ttctcagacc ttgagaaata tcactttaat tcaaggtcct     1020

cctggacccc cgggtgaaaa aggagatcga ggtcccactg gagaaagtgg tccacgagga     1080

tttccaggtc caataggtcc tccgggtctt aaaggtgatc ggggagcaat tggctttcct     1140

ggaagtcgag gactcccagg atatgccgga aggccaggaa attctggacc aaaaggccag     1200

aaaggggaaa aggggagtgg aaacacatta agtactggtc caatatggct gaatgaagtg     1260

ttttgttttg ggagagaatc atctattgaa gaatgtaaaa ttcggcaatg ggggacaaga     1320

gcctgttcac attctgaaga tgctggagtc acttgcactt tataatgcat catattttca     1380

ttcacaacta tgaaatcgct gctcaaaaat gattttatta ccttgttcct gtaaaatcca     1440

tttaatcaat atttaagaga ttaagaatat tgcccaaata atattttaga ttacaggatt     1500

aatatattga acaccttcat gcttactatt ttatgtctat atttaaatca ttttaacttc     1560

tataggtttt taaatggaat tttctaatat aatgacttat atgctgaatt gaacattttg     1620

aagtttatag cttccagatt acaaaggcca agggtaatag aaatgcatac cagtaattgg     1680

ctccaattca taatatgttc accaggagat tacaattttt tgctcttctt gtctttgtaa     1740

tctatttagt tgattttaat tactttctga ataacggaag ggatcagaag atatcttttg     1800

tgcctagatt gcaaaatctc caatccacac atattgtttt aaaataagaa tgttatccaa     1860

ctattaagat atctcaatgt gcaataactt gtgtattaga tatcaatgtt aatgatatgt     1920

cttggccact atggaccagg gagcttattt ttcttgtcat gtactgacaa ctgtttaatt     1980

gaatcatgaa gtaaattgaa agcaggacat atgagaaaac tgaccatcag tatatttgtc     2040

cagataattg gtggatcaaa aatgccactt aacaggaagt ttagtttgtt atgcacttta     2100

aatggaataa ttagcttgtt acaattctag gacatggtgt ttaaaattta aatctgatta     2160

atccatttta acaaacaatg caaacatctt cagtgcagaa ggaagagtgg tttcaactgt     2220

ttggagtctt ttatgaagtc agtcaacatt tacaaccaaa gggcgggggg gggggtgggg     2280

ggtgcgtctt tagtcctaaa gggacaataa ctctgagcat gccccaaaaa agtagtttag     2340

caaccttttg ttggtagtca acccatcccc agggccatag tgtagagtgt gaaaagctac     2400

cctgaaaccc agtaattcta ccctgaaagt gactgcctgc agaaagacca gcagttgata     2460

ttaaagcgca aatgaattca acctcagccc tgaaaataac agaattctga agtttcctat     2520

gactaattca caaaaaaagt aattgtaaac tagtactatt atggaattac tctactgttc     2580

tttctttaat agtggcaaat gaaagcataa gcttaagcat tttttcatat tctgaagtct     2640

caccacacat aataaccaag tggtagactc acagccgtcc aacttaaaaa ggcaaaacct     2700

taccttggaa ttggaattac tgtaaacagc ctactgaaaa tgcattttta tcatgtaaca     2760

ttcttctact tgtttaacat tgctgatttt ctctggcagc ataattttgt ggttaagaga     2820

atgaattctg aatgtacact ttctgtctca aaccctggct gtaatttcag ctagttaata     2880

attctttgtg ttcagttcca ctatctaggt attttcttca aaaggtaaat acaatggttt     2940

ctgaaagaat catttgcatt atcagcctgt ttgggatgtc tgagatcagt gcctctgggt     3000

tgttaatact gtattgctgt atggtatatg tatgctgatt tactacttat gcgtaagtgg     3060

tatgcatggg atgtctgaaa tcagtgccta tgggttgtca atagtattaa ctattagtgt     3120

taactgttag tattaactat tagtattatt aacactaata atagtactat tactattact     3180

atttttattt taaaataaaa tttaccttta aaataataat agtactattg ctagtactag     3240

tactattgct attactagta ctattactag tactagtact atgacactgt taatagtact     3300

attaacaacc cataggcact tgggatgtct gagatcagtg cctatgggtt gttaatacta     3360

tattgctgta tggtatatgc atgctgattt accacttatg catagatata tctttaataa     3420

gtaatctaaa aatccttttt gtatttgaga gaatctacta agttcagtcc agtcaagaaa     3480

agaacctaat agcaccaata caaattgagg acttaattta ctttggaatg ttgaattgca     3540

tttgttccat taaaaaaaac agaaatttgc ga                                   3572


<210>  6
<211>  388
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Glu Gln Trp Asp His Phe His Asn Gln Gln Glu Asp Thr Asp Ser 
1               5                   10                  15      


Cys Ser Glu Ser Val Lys Phe Asp Ala Arg Ser Met Thr Ala Leu Leu 
            20                  25                  30          


Pro Pro Asn Pro Lys Asn Ser Pro Ser Leu Gln Glu Lys Leu Lys Ser 
        35                  40                  45              


Phe Lys Ala Ala Leu Ile Ala Leu Tyr Leu Leu Val Phe Ala Val Leu 
    50                  55                  60                  


Ile Pro Leu Ile Gly Ile Val Ala Ala Gln Leu Leu Lys Trp Glu Thr 
65                  70                  75                  80  


Lys Asn Cys Ser Val Ser Ser Thr Asn Ala Asn Asp Ile Thr Gln Ser 
                85                  90                  95      


Leu Thr Gly Lys Gly Asn Asp Ser Glu Glu Glu Met Arg Phe Gln Glu 
            100                 105                 110         


Val Phe Met Glu His Met Ser Asn Met Glu Lys Arg Ile Gln His Ile 
        115                 120                 125             


Leu Asp Met Glu Ala Asn Leu Met Asp Thr Glu His Phe Gln Asn Phe 
    130                 135                 140                 


Ser Met Thr Thr Asp Gln Arg Phe Asn Asp Ile Leu Leu Gln Leu Ser 
145                 150                 155                 160 


Thr Leu Phe Ser Ser Val Gln Gly His Gly Asn Ala Ile Asp Glu Ile 
                165                 170                 175     


Ser Lys Ser Leu Ile Ser Leu Asn Thr Thr Leu Leu Asp Leu Gln Leu 
            180                 185                 190         


Asn Ile Glu Asn Leu Asn Gly Lys Ile Gln Glu Asn Thr Phe Lys Gln 
        195                 200                 205             


Gln Glu Glu Ile Ser Lys Leu Glu Glu Arg Val Tyr Asn Val Ser Ala 
    210                 215                 220                 


Glu Ile Met Ala Met Lys Glu Glu Gln Val His Leu Glu Gln Glu Ile 
225                 230                 235                 240 


Lys Gly Glu Val Lys Val Leu Asn Asn Ile Thr Asn Asp Leu Arg Leu 
                245                 250                 255     


Lys Asp Trp Glu His Ser Gln Thr Leu Arg Asn Ile Thr Leu Ile Gln 
            260                 265                 270         


Gly Pro Pro Gly Pro Pro Gly Glu Lys Gly Asp Arg Gly Pro Thr Gly 
        275                 280                 285             


Glu Ser Gly Pro Arg Gly Phe Pro Gly Pro Ile Gly Pro Pro Gly Leu 
    290                 295                 300                 


Lys Gly Asp Arg Gly Ala Ile Gly Phe Pro Gly Ser Arg Gly Leu Pro 
305                 310                 315                 320 


Gly Tyr Ala Gly Arg Pro Gly Asn Ser Gly Pro Lys Gly Gln Lys Gly 
                325                 330                 335     


Glu Lys Gly Ser Gly Asn Thr Leu Ser Thr Gly Pro Ile Trp Leu Asn 
            340                 345                 350         


Glu Val Phe Cys Phe Gly Arg Glu Ser Ser Ile Glu Glu Cys Lys Ile 
        355                 360                 365             


Arg Gln Trp Gly Thr Arg Ala Cys Ser His Ser Glu Asp Ala Gly Val 
    370                 375                 380                 


Thr Cys Thr Leu 
385             


<210>  7
<211>  131
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Trp Leu Gln Ser Leu Leu Leu Leu Gly Thr Val Ala Cys Ser Ile 
1               5                   10                  15      


Ser Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu 
            20                  25                  30          


Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val 
        35                  40                  45              


His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu 
    50                  55                  60                  


Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val 
65                  70                  75                  80  


Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn 
                85                  90                  95      


Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn 
            100                 105                 110         


Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile 
        115                 120                 125             


Asn Thr Ser 
    130     


<210>  8
<211>  170
<212>  PRT
<213>  Homo sapiens

<400>  8

Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val 
1               5                   10                  15      


Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly 
            20                  25                  30          


Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn 
        35                  40                  45              


Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile 
    50                  55                  60                  


Arg Asp Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Thr Val 
65                  70                  75                  80  


Thr Thr Ala Gly Val Thr Pro Gln Pro Glu Ser Leu Ser Pro Ser Gly 
                85                  90                  95      


Lys Glu Pro Ala Ala Ser Ser Pro Ser Ser Asn Asn Thr Ala Ala Thr 
            100                 105                 110         


Thr Ala Ala Ile Val Pro Gly Ser Gln Leu Met Pro Ser Lys Ser Pro 
        115                 120                 125             


Ser Thr Gly Thr Thr Glu Ile Ser Ser His Glu Ser Ser His Gly Thr 
    130                 135                 140                 


Pro Ser Gln Thr Thr Ala Lys Asn Trp Glu Leu Thr Ala Ser Ala Ser 
145                 150                 155                 160 


His Gln Pro Pro Gly Val Tyr Pro Gln Gly 
                165                 170 


<210>  9
<211>  337
<212>  PRT
<213>  Homo sapiens

<400>  9

Pro Ser Tyr Thr Cys Thr Cys Leu Lys Gly Tyr Ala Gly Asn His Cys 
1               5                   10                  15      


Glu Thr Lys Cys Val Glu Pro Leu Gly Met Glu Asn Gly Asn Ile Ala 
            20                  25                  30          


Asn Ser Gln Ile Ala Ala Ser Ser Val Arg Val Thr Phe Leu Gly Leu 
        35                  40                  45              


Gln His Trp Val Pro Glu Leu Ala Arg Leu Asn Arg Ala Gly Met Val 
    50                  55                  60                  


Asn Ala Trp Thr Pro Ser Ser Asn Asp Asp Asn Pro Trp Ile Gln Val 
65                  70                  75                  80  


Asn Leu Leu Arg Arg Met Trp Val Thr Gly Val Val Thr Gln Gly Ala 
                85                  90                  95      


Ser Arg Leu Ala Ser His Glu Tyr Leu Lys Ala Phe Lys Val Ala Tyr 
            100                 105                 110         


Ser Leu Asn Gly His Glu Phe Asp Phe Ile His Asp Val Asn Lys Lys 
        115                 120                 125             


His Lys Glu Phe Val Gly Asn Trp Asn Lys Asn Ala Val His Val Asn 
    130                 135                 140                 


Leu Phe Glu Thr Pro Val Glu Ala Gln Tyr Val Arg Leu Tyr Pro Thr 
145                 150                 155                 160 


Ser Cys His Thr Ala Cys Thr Leu Arg Phe Glu Leu Leu Gly Cys Glu 
                165                 170                 175     


Leu Asn Gly Cys Ala Asn Pro Leu Gly Leu Lys Asn Asn Ser Ile Pro 
            180                 185                 190         


Asp Lys Gln Ile Thr Ala Ser Ser Ser Tyr Lys Thr Trp Gly Leu His 
        195                 200                 205             


Leu Phe Ser Trp Asn Pro Ser Tyr Ala Arg Leu Asp Lys Gln Gly Asn 
    210                 215                 220                 


Phe Asn Ala Trp Val Ala Gly Ser Tyr Gly Asn Asp Gln Trp Leu Gln 
225                 230                 235                 240 


Val Asp Leu Gly Ser Ser Lys Glu Val Thr Gly Ile Ile Thr Gln Gly 
                245                 250                 255     


Ala Arg Asn Phe Gly Ser Val Gln Phe Val Ala Ser Tyr Lys Val Ala 
            260                 265                 270         


Tyr Ser Asn Asp Ser Ala Asn Trp Thr Glu Tyr Gln Asp Pro Arg Thr 
        275                 280                 285             


Gly Ser Ser Lys Ile Phe Pro Gly Asn Trp Asp Asn His Ser His Lys 
    290                 295                 300                 


Lys Asn Leu Phe Glu Thr Pro Ile Leu Ala Arg Tyr Val Arg Ile Leu 
305                 310                 315                 320 


Pro Val Ala Trp His Asn Arg Ile Ala Leu Arg Leu Glu Leu Leu Gly 
                325                 330                 335     


Cys 
    


<210>  10
<211>  507
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  10

Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val 
1               5                   10                  15      


Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly 
            20                  25                  30          


Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn 
        35                  40                  45              


Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile 
    50                  55                  60                  


Arg Asp Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Thr Val 
65                  70                  75                  80  


Thr Thr Ala Gly Val Thr Pro Gln Pro Glu Ser Leu Ser Pro Ser Gly 
                85                  90                  95      


Lys Glu Pro Ala Ala Ser Ser Pro Ser Ser Asn Asn Thr Ala Ala Thr 
            100                 105                 110         


Thr Ala Ala Ile Val Pro Gly Ser Gln Leu Met Pro Ser Lys Ser Pro 
        115                 120                 125             


Ser Thr Gly Thr Thr Glu Ile Ser Ser His Glu Ser Ser His Gly Thr 
    130                 135                 140                 


Pro Ser Gln Thr Thr Ala Lys Asn Trp Glu Leu Thr Ala Ser Ala Ser 
145                 150                 155                 160 


His Gln Pro Pro Gly Val Tyr Pro Gln Gly Pro Ser Tyr Thr Cys Thr 
                165                 170                 175     


Cys Leu Lys Gly Tyr Ala Gly Asn His Cys Glu Thr Lys Cys Val Glu 
            180                 185                 190         


Pro Leu Gly Met Glu Asn Gly Asn Ile Ala Asn Ser Gln Ile Ala Ala 
        195                 200                 205             


Ser Ser Val Arg Val Thr Phe Leu Gly Leu Gln His Trp Val Pro Glu 
    210                 215                 220                 


Leu Ala Arg Leu Asn Arg Ala Gly Met Val Asn Ala Trp Thr Pro Ser 
225                 230                 235                 240 


Ser Asn Asp Asp Asn Pro Trp Ile Gln Val Asn Leu Leu Arg Arg Met 
                245                 250                 255     


Trp Val Thr Gly Val Val Thr Gln Gly Ala Ser Arg Leu Ala Ser His 
            260                 265                 270         


Glu Tyr Leu Lys Ala Phe Lys Val Ala Tyr Ser Leu Asn Gly His Glu 
        275                 280                 285             


Phe Asp Phe Ile His Asp Val Asn Lys Lys His Lys Glu Phe Val Gly 
    290                 295                 300                 


Asn Trp Asn Lys Asn Ala Val His Val Asn Leu Phe Glu Thr Pro Val 
305                 310                 315                 320 


Glu Ala Gln Tyr Val Arg Leu Tyr Pro Thr Ser Cys His Thr Ala Cys 
                325                 330                 335     


Thr Leu Arg Phe Glu Leu Leu Gly Cys Glu Leu Asn Gly Cys Ala Asn 
            340                 345                 350         


Pro Leu Gly Leu Lys Asn Asn Ser Ile Pro Asp Lys Gln Ile Thr Ala 
        355                 360                 365             


Ser Ser Ser Tyr Lys Thr Trp Gly Leu His Leu Phe Ser Trp Asn Pro 
    370                 375                 380                 


Ser Tyr Ala Arg Leu Asp Lys Gln Gly Asn Phe Asn Ala Trp Val Ala 
385                 390                 395                 400 


Gly Ser Tyr Gly Asn Asp Gln Trp Leu Gln Val Asp Leu Gly Ser Ser 
                405                 410                 415     


Lys Glu Val Thr Gly Ile Ile Thr Gln Gly Ala Arg Asn Phe Gly Ser 
            420                 425                 430         


Val Gln Phe Val Ala Ser Tyr Lys Val Ala Tyr Ser Asn Asp Ser Ala 
        435                 440                 445             


Asn Trp Thr Glu Tyr Gln Asp Pro Arg Thr Gly Ser Ser Lys Ile Phe 
    450                 455                 460                 


Pro Gly Asn Trp Asp Asn His Ser His Lys Lys Asn Leu Phe Glu Thr 
465                 470                 475                 480 


Pro Ile Leu Ala Arg Tyr Val Arg Ile Leu Pro Val Ala Trp His Asn 
                485                 490                 495     


Arg Ile Ala Leu Arg Leu Glu Leu Leu Gly Cys 
            500                 505         


<210>  11
<211>  1617
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  11
atggccccga ggcgggcgcg aggctgccgg accctcggtc tcccggcgct gctactgctc       60

ctgctgctcc ggccgccggc gacgcggggc atcacgtgcc cgccccccat gtccgtggag      120

cacgcagaca tctgggtcaa gagctacagc ttgtactccc gggagcggta catctgcaac      180

tcgggtttca agcggaaggc cggcacgtcc agcctgacgg agtgcgtgtt gaacaaggcc      240

acgaatgtcg cccactggac gaccccctcg ctcaagtgca tccgcgaccc ggccctggtt      300

caccagcggc ccgcgccacc ctccaccgta acgacggcgg gggtgacccc tcagcctgag      360

agcctgagcc ctagcggaaa agagcctgcc gccagcagcc ccagcagcaa caatactgcc      420

gccaccacag ccgccatcgt gcctggatct cagctgatgc ccagcaagag cccaagcacc      480

ggcaccaccg agatcagcag ccacgagtct agccacggca cccctagcca gaccaccgcc      540

aagaattggg agctgacagc cagcgccagc caccagcctc caggcgtgta ccctcaggga      600

cccagctaca cctgtacctg cctgaagggc tacgccggca accactgcga gactaagtgc      660

gtggaacccc tgggcatgga aaacggcaat atcgccaaca gccagatcgc cgccagctcc      720

gtcagagtga cctttctggg actgcagcac tgggtgcccg agctggccag actgaataga      780

gccggcatgg tcaacgcctg gacccccagc tccaacgacg acaacccttg gatccaagtg      840

aacctgctgc ggcgtatgtg ggtcacaggc gtcgtgacac agggcgcctc tagactggcc      900

tcccacgagt acctgaaggc ctttaaggtg gcctacagcc tgaacggcca cgagttcgac      960

ttcatccacg acgtgaacaa gaaacacaaa gaatttgtgg gcaactggaa caagaacgcc     1020

gtgcacgtga acctgttcga gacacccgtg gaagcccagt acgtgcggct gtaccctacc     1080

agctgtcaca ccgcctgcac cctgagattc gagctgctgg gatgcgagct gaacggctgc     1140

gccaatcctc tgggcctgaa gaacaacagc atccccgaca agcagatcac cgcctccagc     1200

agctacaaga cctggggcct gcacctgttc agctggaacc ctagctacgc ccggctggac     1260

aagcagggca acttcaatgc ttgggtggcc ggcagctacg gcaacgacca gtggctgcag     1320

gtggacctgg gcagcagcaa agaagtgacc ggcatcatca cccagggcgc cagaaacttc     1380

ggcagcgtgc agttcgtggc ctcctacaaa gtggcctact ccaacgatag cgccaactgg     1440

accgagtacc aggaccccag aaccggcagc tccaagattt tccccggcaa ctgggataac     1500

cacagccaca agaagaatct gttcgaaacc cccatcctgg cccgctacgt gcggattctg     1560

cctgtggcct ggcacaaccg gatcgccctg agactggaac tgctgggctg ttgatga        1617


<210>  12
<211>  396
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  12
tcacgacgtg ttgatgaaca tctggacgat gtgcacgaac gactgcagga actccttgat       60

gttcttctcc tccagctcct cgcactcctt gcagcccgac tccgtgacgt tcccgttcga      120

cgacagcgag ttgttcgcca ggatgatcag gttctccacc gtgtcgtgga tcgacgcgtc      180

ccccgactcg agcgagatga cttggagctc caggaggaag cacttcatcg ccgtgacctt      240

gcacgacggg tggacgtccg actccgtgta cagcgtcgcg tcgatgtgca tcgactggat      300

gaggtcctcg atcttcttca ggtccgagat cacgttcacc cagttcgaga tgctgcaggc      360

caccgtcccc aggagtagca ggctctggag ccacat                                396


<210>  13
<211>  6672
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  13
cctggccatt gcatacgttg tatccatatc ataatatgta catttatatt ggctcatgtc       60

caacattacc gccatgttga cattgattat tgactagtta ttaatagtaa tcaattacgg      120

ggtcattagt tcatagccca tatatggagt tccgcgttac ataacttacg gtaaatggcc      180

cgcctggctg accgcccaac gacccccgcc cattgacgtc aataatgacg tatgttccca      240

tagtaacgcc aatagggact ttccattgac gtcaatgggt ggagtattta cggtaaactg      300

cccacttggc agtacatcaa gtgtatcata tgccaagtac gccccctatt gacgtcaatg      360

atggtaaatg gcccgcctgg cattatgccc agtacatgac cttatgggac tttcctactt      420

ggcagtacat ctacgtatta gtcatcgcta ttaccatggt gatgcggttt tggcagtaca      480

tcaatgggcg tggatagcgg tttgactcac ggggatttcc aagtctccac cccattgacg      540

tcaatgggag tttgttttgg caccaaaatc aacgggactt tccaaaatgt cgtaacaact      600

ccgccccatt gacgcaaatg ggcggtaggc gtgtacggtg ggaggtctat ataagcagag      660

ctcgtttagt gaaccgtcag atcgcctgga gacgccatcc acgctgtttt gacctccata      720

gaagacaccg ggaccgatcc agcctccgcg ggcgcgcgtc gaggaattcg ctagcaagaa      780

atggccccga ggcgggcgcg aggctgccgg accctcggtc tcccggcgct gctactgctc      840

ctgctgctcc ggccgccggc gacgcggggc atcacgtgcc cgccccccat gtccgtggag      900

cacgcagaca tctgggtcaa gagctacagc ttgtactccc gggagcggta catctgcaac      960

tcgggtttca agcggaaggc cggcacgtcc agcctgacgg agtgcgtgtt gaacaaggcc     1020

acgaatgtcg cccactggac gaccccctcg ctcaagtgca tccgcgaccc ggccctggtt     1080

caccagcggc ccgcgccacc ctccaccgta acgacggcgg gggtgacccc tcagcctgag     1140

agcctgagcc ctagcggaaa agagcctgcc gccagcagcc ccagcagcaa caatactgcc     1200

gccaccacag ccgccatcgt gcctggatct cagctgatgc ccagcaagag cccaagcacc     1260

ggcaccaccg agatcagcag ccacgagtct agccacggca cccctagcca gaccaccgcc     1320

aagaattggg agctgacagc cagcgccagc caccagcctc caggcgtgta ccctcaggga     1380

cccagctaca cctgtacctg cctgaagggc tacgccggca accactgcga gactaagtgc     1440

gtggaacccc tgggcatgga aaacggcaat atcgccaaca gccagatcgc cgccagctcc     1500

gtcagagtga cctttctggg actgcagcac tgggtgcccg agctggccag actgaataga     1560

gccggcatgg tcaacgcctg gacccccagc tccaacgacg acaacccttg gatccaagtg     1620

aacctgctgc ggcgtatgtg ggtcacaggc gtcgtgacac agggcgcctc tagactggcc     1680

tcccacgagt acctgaaggc ctttaaggtg gcctacagcc tgaacggcca cgagttcgac     1740

ttcatccacg acgtgaacaa gaaacacaaa gaatttgtgg gcaactggaa caagaacgcc     1800

gtgcacgtga acctgttcga gacacccgtg gaagcccagt acgtgcggct gtaccctacc     1860

agctgtcaca ccgcctgcac cctgagattc gagctgctgg gatgcgagct gaacggctgc     1920

gccaatcctc tgggcctgaa gaacaacagc atccccgaca agcagatcac cgcctccagc     1980

agctacaaga cctggggcct gcacctgttc agctggaacc ctagctacgc ccggctggac     2040

aagcagggca acttcaatgc ttgggtggcc ggcagctacg gcaacgacca gtggctgcag     2100

gtggacctgg gcagcagcaa agaagtgacc ggcatcatca cccagggcgc cagaaacttc     2160

ggcagcgtgc agttcgtggc ctcctacaaa gtggcctact ccaacgatag cgccaactgg     2220

accgagtacc aggaccccag aaccggcagc tccaagattt tccccggcaa ctgggataac     2280

cacagccaca agaagaatct gttcgaaacc cccatcctgg cccgctacgt gcggattctg     2340

cctgtggcct ggcacaaccg gatcgccctg agactggaac tgctgggctg ttgatgagaa     2400

ttcgcggata tcggttaacg gatccagatc tgctgtgcct tctagttgcc agccatctgt     2460

tgtttgcccc tcccccgtgc cttccttgac cctggaaggt gccactccca ctgtcctttc     2520

ctaataaaat gaggaaattg catcgcattg tctgagtagg tgtcattcta ttctgggggg     2580

tggggtgggg caggacagca agggggagga ttgggaagac aatagcaggc atgctgggga     2640

tgcggtgggc tctatgggta cccaggtgct gaagaattga cccggttcct cctgggccag     2700

aaagaagcag gcacatcccc ttctctgtga cacaccctgt ccacgcccct ggttcttagt     2760

tccagcccca ctcataggac actcatagct caggagggct ccgccttcaa tcccacccgc     2820

taaagtactt ggagcggtct ctccctccct catcagccca ccaaaccaaa cctagcctcc     2880

aagagtggga agaaattaaa gcaagatagg ctattaagtg cagagggaga gaaaatgcct     2940

ccaacatgtg aggaagtaat gagagaaatc atagaatttc ttccgcttcc tcgctcactg     3000

actcgctgcg ctcggtcgtt cggctgcggc gagcggtatc agctcactca aaggcggtaa     3060

tacggttatc cacagaatca ggggataacg caggaaagaa catgtgagca aaaggccagc     3120

aaaaggccag gaaccgtaaa aaggccgcgt tgctggcgtt tttccatagg ctccgccccc     3180

ctgacgagca tcacaaaaat cgacgctcaa gtcagaggtg gcgaaacccg acaggactat     3240

aaagatacca ggcgtttccc cctggaagct ccctcgtgcg ctctcctgtt ccgaccctgc     3300

cgcttaccgg atacctgtcc gcctttctcc cttcgggaag cgtggcgctt tctcatagct     3360

cacgctgtag gtatctcagt tcggtgtagg tcgttcgctc caagctgggc tgtgtgcacg     3420

aaccccccgt tcagcccgac cgctgcgcct tatccggtaa ctatcgtctt gagtccaacc     3480

cggtaagaca cgacttatcg ccactggcag cagccactgg taacaggatt agcagagcga     3540

ggtatgtagg cggtgctaca gagttcttga agtggtggcc taactacggc tacactagaa     3600

gaacagtatt tggtatctgc gctctgctga agccagttac cttcggaaaa agagttggta     3660

gctcttgatc cggcaaacaa accaccgctg gtagcggtgg tttttttgtt tgcaagcagc     3720

agattacgcg cagaaaaaaa ggatctcaag aagatccttt gatcttttct acggggtctg     3780

acgctcagtg gaacgaaaac tcacgttaag ggattttggt catgagatta tcaaaaagga     3840

tcttcaccta gatcctttta aattaaaaat gaagttttaa atcaatctaa agtatatatg     3900

agtaaacttg gtctgacagt taccaatgct taatcagtga ggcacctatc tcagcgatct     3960

gtctatttcg ttcatccata gttgcctgac tcgggggggg ggggcgctga ggtctgcctc     4020

gtgaagaagg tgttgctgac tcataccagg cctgaatcgc cccatcatcc agccagaaag     4080

tgagggagcc acggttgatg agagctttgt tgtaggtgga ccagttggtg attttgaact     4140

tttgctttgc cacggaacgg tctgcgttgt cgggaagatg cgtgatctga tccttcaact     4200

cagcaaaagt tcgatttatt caacaaagcc gccgtcccgt caagtcagcg taatgctctg     4260

ccagtgttac aaccaattaa ccaattctga ttagaaaaac tcatcgagca tcaaatgaaa     4320

ctgcaattta ttcatatcag gattatcaat accatatttt tgaaaaagcc gtttctgtaa     4380

tgaaggagaa aactcaccga ggcagttcca taggatggca agatcctggt atcggtctgc     4440

gattccgact cgtccaacat caatacaacc tattaatttc ccctcgtcaa aaataaggtt     4500

atcaagtgag aaatcaccat gagtgacgac tgaatccggt gagaatggca aaagcttatg     4560

catttctttc cagacttgtt caacaggcca gccattacgc tcgtcatcaa aatcactcgc     4620

atcaaccaaa ccgttattca ttcgtgattg cgcctgagcg agacgaaata cgcgatcgct     4680

gttaaaagga caattacaaa caggaatcga atgcaaccgg cgcaggaaca ctgccagcgc     4740

atcaacaata ttttcacctg aatcaggata ttcttctaat acctggaatg ctgttttccc     4800

ggggatcgca gtggtgagta accatgcatc atcaggagta cggataaaat gcttgatggt     4860

cggaagaggc ataaattccg tcagccagtt tagtctgacc atctcatctg taacatcatt     4920

ggcaacgcta cctttgccat gtttcagaaa caactctggc gcatcgggct tcccatacaa     4980

tcgatagatt gtcgcacctg attgcccgac attatcgcga gcccatttat acccatataa     5040

atcagcatcc atgttggaat ttaatcgcgg cctcgagcaa gacgtttccc gttgaatatg     5100

gctcataaca ccccttgtat tactgtttat gtaagcagac agttttattg ttcatgatga     5160

tatattttta tcttgtgcaa tgtaacatca gagattttga gacacaacgt ggatcatcca     5220

gacatgataa gatacattga tgagtttgga caaaccacaa ctagaatgca gtgaaaaaaa     5280

tgctttattt gtgaaatttg tgatgctatt gctttatttg taaccattat aagctgcaat     5340

aaacaagtta acaacaacaa ttgcattcat tttatgtttc aggttcaggg ggaggtgtgg     5400

gaggtttttt aaagcaagta aaacctctac aaatgtggta tggctgatta tgatcgtcga     5460

ggatctggat ccgttaaccg atatccgcga attcggcgcg ccgggccctc acgacgtgtt     5520

gatgaacatc tggacgatgt gcacgaacga ctgcaggaac tccttgatgt tcttctcctc     5580

cagctcctcg cactccttgc agcccgactc cgtgacgttc ccgttcgacg acagcgagtt     5640

gttcgccagg atgatcaggt tctccaccgt gtcgtggatc gacgcgtccc ccgactcgag     5700

cgagatgact tggagctcca ggaggaagca cttcatcgcc gtgaccttgc acgacgggtg     5760

gacgtccgac tccgtgtaca gcgtcgcgtc gatgtgcatc gactggatga ggtcctcgat     5820

cttcttcagg tccgagatca cgttcaccca gttcgagatg ctgcaggcca ccgtccccag     5880

gagtagcagg ctctggagcc acatttcttg tcgacagatc caaacgctcc tccgacgtcc     5940

ccaggcagaa tggcggttcc ctaaacgagc attgcttata tagacctccc attaggcacg     6000

cctaccgccc atttacgtca atggaacgcc catttgcgtc attgcccctc cccattgacg     6060

tcaatgggga tgtacttggc agccatcgcg ggccatttac cgccattgac gtcaatggga     6120

gtactgccaa tgtaccctgg cgtacttcca atagtaatgt acttgccaag ttactattaa     6180

tagatattga tgtactgcca agtgggccat ttaccgtcat tgacgtcaat agggggcgtg     6240

agaacggata tgaatgggca atgagccatc ccattgacgt caatggtggg tggtcctatt     6300

gacgtcaatg ggcattgagc caggcgggcc atttaccgta attgacgtca atgggggagg     6360

cgccatatac gtcaatagga ccgcccatat gacgtcaata ggtaagacca tgaggccctt     6420

tcgtctcgcg cgtttcggtg atgacggtga aaacctctga cacatgcagc tcccggagac     6480

ggtcacagct tgtctgtaag cggatgccgg gagcagacaa gcccgtcagg gcgcgtcagc     6540

gggtgttggc gggtgtcggg gctggcttaa ctatgcggca tcagagcaga ttgtactgag     6600

agtgcaccat atgcggtgtg aaataccgca cagatgcgta aggagaaaat accgcatcag     6660

attggctatt gg                                                         6672


<210>  14
<211>  267
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  14

Met Ala Pro Arg Arg Ala Arg Gly Cys Arg Thr Leu Gly Leu Pro Ala 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Leu Arg Pro Pro Ala Thr Arg Gly Ile Thr 
            20                  25                  30          


Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val Lys Ser 
        35                  40                  45              


Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe Lys 
    50                  55                  60                  


Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn Lys Ala 
65                  70                  75                  80  


Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile Arg Asp 
                85                  90                  95      


Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Thr Val Thr Thr 
            100                 105                 110         


Ala Gly Val Thr Pro Gln Pro Glu Ser Leu Ser Pro Ser Gly Lys Glu 
        115                 120                 125             


Pro Ala Ala Ser Ser Pro Ser Ser Asn Asn Thr Ala Ala Thr Thr Ala 
    130                 135                 140                 


Ala Ile Val Pro Gly Ser Gln Leu Met Pro Ser Lys Ser Pro Ser Thr 
145                 150                 155                 160 


Gly Thr Thr Glu Ile Ser Ser His Glu Ser Ser His Gly Thr Pro Ser 
                165                 170                 175     


Gln Thr Thr Ala Lys Asn Trp Glu Leu Thr Ala Ser Ala Ser His Gln 
            180                 185                 190         


Pro Pro Gly Val Tyr Pro Gln Gly His Ser Asp Thr Thr Val Ala Ile 
        195                 200                 205             


Ser Thr Ser Thr Val Leu Leu Cys Gly Leu Ser Ala Val Ser Leu Leu 
    210                 215                 220                 


Ala Cys Tyr Leu Lys Ser Arg Gln Thr Pro Pro Leu Ala Ser Val Glu 
225                 230                 235                 240 


Met Glu Ala Met Glu Ala Leu Pro Val Thr Trp Gly Thr Ser Ser Arg 
                245                 250                 255     


Asp Glu Asp Leu Glu Asn Cys Ser His His Leu 
            260                 265         


<210>  15
<211>  807
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  15
atggccccga ggcgggcgcg aggctgccgg accctcggtc tcccggcgct gctactgctc       60

ctgctgctcc ggccgccggc gacgcggggc atcacgtgcc cgccccccat gtccgtggag      120

cacgcagaca tctgggtcaa gagctacagc ttgtactccc gggagcggta catctgcaac      180

tcgggtttca agcggaaggc cggcacgtcc agcctgacgg agtgcgtgtt gaacaaggcc      240

acgaatgtcg cccactggac gaccccctcg ctcaagtgca tccgcgaccc ggccctggtt      300

caccagcggc ccgcgccacc ctccaccgta acgacggcgg gggtgacccc gcagccggag      360

agcctctccc cgtcgggaaa ggagcccgcc gcgtcgtcgc ccagctcgaa caacacggcg      420

gccacaactg cagcgatcgt cccgggctcc cagctgatgc cgtcgaagtc gccgtccacg      480

ggaaccacgg agatcagcag tcatgagtcc tcccacggca ccccctcgca aacgacggcc      540

aagaactggg aactcacggc gtccgcctcc caccagccgc cgggggtgta tccgcaaggc      600

cacagcgaca ccacggtggc gatctccacg tccacggtcc tgctgtgtgg gctgagcgcg      660

gtgtcgctcc tggcgtgcta cctcaagtcg aggcagactc ccccgctggc cagcgttgag      720

atggaggcca tggaggctct gccggtgacg tgggggacca gcagcaggga tgaggacttg      780

gagaactgct cgcaccacct ataatga                                          807


<210>  16
<211>  5858
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  16
cctggccatt gcatacgttg tatccatatc ataatatgta catttatatt ggctcatgtc       60

caacattacc gccatgttga cattgattat tgactagtta ttaatagtaa tcaattacgg      120

ggtcattagt tcatagccca tatatggagt tccgcgttac ataacttacg gtaaatggcc      180

cgcctggctg accgcccaac gacccccgcc cattgacgtc aataatgacg tatgttccca      240

tagtaacgcc aatagggact ttccattgac gtcaatgggt ggagtattta cggtaaactg      300

cccacttggc agtacatcaa gtgtatcata tgccaagtac gccccctatt gacgtcaatg      360

atggtaaatg gcccgcctgg cattatgccc agtacatgac cttatgggac tttcctactt      420

ggcagtacat ctacgtatta gtcatcgcta ttaccatggt gatgcggttt tggcagtaca      480

tcaatgggcg tggatagcgg tttgactcac ggggatttcc aagtctccac cccattgacg      540

tcaatgggag tttgttttgg caccaaaatc aacgggactt tccaaaatgt cgtaacaact      600

ccgccccatt gacgcaaatg ggcggtaggc gtgtacggtg ggaggtctat ataagcagag      660

ctcgtttagt gaaccgtcag atcgcctgga gacgccatcc acgctgtttt gacctccata      720

gaagacaccg ggaccgatcc agcctccgcg ggcgcgcgtc gaggaattcg ctagcaagaa      780

atggccccga ggcgggcgcg aggctgccgg accctcggtc tcccggcgct gctactgctc      840

ctgctgctcc ggccgccggc gacgcggggc atcacgtgcc cgccccccat gtccgtggag      900

cacgcagaca tctgggtcaa gagctacagc ttgtactccc gggagcggta catctgcaac      960

tcgggtttca agcggaaggc cggcacgtcc agcctgacgg agtgcgtgtt gaacaaggcc     1020

acgaatgtcg cccactggac gaccccctcg ctcaagtgca tccgcgaccc ggccctggtt     1080

caccagcggc ccgcgccacc ctccaccgta acgacggcgg gggtgacccc gcagccggag     1140

agcctctccc cgtcgggaaa ggagcccgcc gcgtcgtcgc ccagctcgaa caacacggcg     1200

gccacaactg cagcgatcgt cccgggctcc cagctgatgc cgtcgaagtc gccgtccacg     1260

ggaaccacgg agatcagcag tcatgagtcc tcccacggca ccccctcgca aacgacggcc     1320

aagaactggg aactcacggc gtccgcctcc caccagccgc cgggggtgta tccgcaaggc     1380

cacagcgaca ccacggtggc gatctccacg tccacggtcc tgctgtgtgg gctgagcgcg     1440

gtgtcgctcc tggcgtgcta cctcaagtcg aggcagactc ccccgctggc cagcgttgag     1500

atggaggcca tggaggctct gccggtgacg tgggggacca gcagcaggga tgaggacttg     1560

gagaactgct cgcaccacct ataatgagaa ttcacgcgtg gatctgatat cggatctgct     1620

gtgccttcta gttgccagcc atctgttgtt tgcccctccc ccgtgccttc cttgaccctg     1680

gaaggtgcca ctcccactgt cctttcctaa taaaatgagg aaattgcatc gcattgtctg     1740

agtaggtgtc attctattct ggggggtggg gtggggcagg acagcaaggg ggaggattgg     1800

gaagacaata gcaggcatgc tggggatgcg gtgggctcta tgggtaccca ggtgctgaag     1860

aattgacccg gttcctcctg ggccagaaag aagcaggcac atccccttct ctgtgacaca     1920

ccctgtccac gcccctggtt cttagttcca gccccactca taggacactc atagctcagg     1980

agggctccgc cttcaatccc acccgctaaa gtacttggag cggtctctcc ctccctcatc     2040

agcccaccaa accaaaccta gcctccaaga gtgggaagaa attaaagcaa gataggctat     2100

taagtgcaga gggagagaaa atgcctccaa catgtgagga agtaatgaga gaaatcatag     2160

aatttcttcc gcttcctcgc tcactgactc gctgcgctcg gtcgttcggc tgcggcgagc     2220

ggtatcagct cactcaaagg cggtaatacg gttatccaca gaatcagggg ataacgcagg     2280

aaagaacatg tgagcaaaag gccagcaaaa ggccaggaac cgtaaaaagg ccgcgttgct     2340

ggcgtttttc cataggctcc gcccccctga cgagcatcac aaaaatcgac gctcaagtca     2400

gaggtggcga aacccgacag gactataaag ataccaggcg tttccccctg gaagctccct     2460

cgtgcgctct cctgttccga ccctgccgct taccggatac ctgtccgcct ttctcccttc     2520

gggaagcgtg gcgctttctc atagctcacg ctgtaggtat ctcagttcgg tgtaggtcgt     2580

tcgctccaag ctgggctgtg tgcacgaacc ccccgttcag cccgaccgct gcgccttatc     2640

cggtaactat cgtcttgagt ccaacccggt aagacacgac ttatcgccac tggcagcagc     2700

cactggtaac aggattagca gagcgaggta tgtaggcggt gctacagagt tcttgaagtg     2760

gtggcctaac tacggctaca ctagaagaac agtatttggt atctgcgctc tgctgaagcc     2820

agttaccttc ggaaaaagag ttggtagctc ttgatccggc aaacaaacca ccgctggtag     2880

cggtggtttt tttgtttgca agcagcagat tacgcgcaga aaaaaaggat ctcaagaaga     2940

tcctttgatc ttttctacgg ggtctgacgc tcagtggaac gaaaactcac gttaagggat     3000

tttggtcatg agattatcaa aaaggatctt cacctagatc cttttaaatt aaaaatgaag     3060

ttttaaatca atctaaagta tatatgagta aacttggtct gacagttacc aatgcttaat     3120

cagtgaggca cctatctcag cgatctgtct atttcgttca tccatagttg cctgactcgg     3180

gggggggggg cgctgaggtc tgcctcgtga agaaggtgtt gctgactcat accaggcctg     3240

aatcgcccca tcatccagcc agaaagtgag ggagccacgg ttgatgagag ctttgttgta     3300

ggtggaccag ttggtgattt tgaacttttg ctttgccacg gaacggtctg cgttgtcggg     3360

aagatgcgtg atctgatcct tcaactcagc aaaagttcga tttattcaac aaagccgccg     3420

tcccgtcaag tcagcgtaat gctctgccag tgttacaacc aattaaccaa ttctgattag     3480

aaaaactcat cgagcatcaa atgaaactgc aatttattca tatcaggatt atcaatacca     3540

tatttttgaa aaagccgttt ctgtaatgaa ggagaaaact caccgaggca gttccatagg     3600

atggcaagat cctggtatcg gtctgcgatt ccgactcgtc caacatcaat acaacctatt     3660

aatttcccct cgtcaaaaat aaggttatca agtgagaaat caccatgagt gacgactgaa     3720

tccggtgaga atggcaaaag cttatgcatt tctttccaga cttgttcaac aggccagcca     3780

ttacgctcgt catcaaaatc actcgcatca accaaaccgt tattcattcg tgattgcgcc     3840

tgagcgagac gaaatacgcg atcgctgtta aaaggacaat tacaaacagg aatcgaatgc     3900

aaccggcgca ggaacactgc cagcgcatca acaatatttt cacctgaatc aggatattct     3960

tctaatacct ggaatgctgt tttcccgggg atcgcagtgg tgagtaacca tgcatcatca     4020

ggagtacgga taaaatgctt gatggtcgga agaggcataa attccgtcag ccagtttagt     4080

ctgaccatct catctgtaac atcattggca acgctacctt tgccatgttt cagaaacaac     4140

tctggcgcat cgggcttccc atacaatcga tagattgtcg cacctgattg cccgacatta     4200

tcgcgagccc atttataccc atataaatca gcatccatgt tggaatttaa tcgcggcctc     4260

gagcaagacg tttcccgttg aatatggctc ataacacccc ttgtattact gtttatgtaa     4320

gcagacagtt ttattgttca tgatgatata tttttatctt gtgcaatgta acatcagaga     4380

ttttgagaca caacgtggat catccagaca tgataagata cattgatgag tttggacaaa     4440

ccacaactag aatgcagtga aaaaaatgct ttatttgtga aatttgtgat gctattgctt     4500

tatttgtaac cattataagc tgcaataaac aagttaacaa caacaattgc attcatttta     4560

tgtttcaggt tcagggggag gtgtgggagg ttttttaaag caagtaaaac ctctacaaat     4620

gtggtatggc tgattatgat cgtcgaggat ctggatccgt taaccgatat ccgcgaattc     4680

ggcgcgccgg gccctcacga cgtgttgatg aacatctgga cgatgtgcac gaacgactgc     4740

aggaactcct tgatgttctt ctcctccagc tcctcgcact ccttgcagcc cgactccgtg     4800

acgttcccgt tcgacgacag cgagttgttc gccaggatga tcaggttctc caccgtgtcg     4860

tggatcgacg cgtcccccga ctcgagcgag atgacttgga gctccaggag gaagcacttc     4920

atcgccgtga ccttgcacga cgggtggacg tccgactccg tgtacagcgt cgcgtcgatg     4980

tgcatcgact ggatgaggtc ctcgatcttc ttcaggtccg agatcacgtt cacccagttc     5040

gagatgctgc aggccaccgt ccccaggagt agcaggctct ggagccacat ttcttgtcga     5100

cagatccaaa cgctcctccg acgtccccag gcagaatggc ggttccctaa acgagcattg     5160

cttatataga cctcccatta ggcacgccta ccgcccattt acgtcaatgg aacgcccatt     5220

tgcgtcattg cccctcccca ttgacgtcaa tggggatgta cttggcagcc atcgcgggcc     5280

atttaccgcc attgacgtca atgggagtac tgccaatgta ccctggcgta cttccaatag     5340

taatgtactt gccaagttac tattaataga tattgatgta ctgccaagtg ggccatttac     5400

cgtcattgac gtcaataggg ggcgtgagaa cggatatgaa tgggcaatga gccatcccat     5460

tgacgtcaat ggtgggtggt cctattgacg tcaatgggca ttgagccagg cgggccattt     5520

accgtaattg acgtcaatgg gggaggcgcc atatacgtca ataggaccgc ccatatgacg     5580

tcaataggta agaccatgag gccctttcgt ctcgcgcgtt tcggtgatga cggtgaaaac     5640

ctctgacaca tgcagctccc ggagacggtc acagcttgtc tgtaagcgga tgccgggagc     5700

agacaagccc gtcagggcgc gtcagcgggt gttggcgggt gtcggggctg gcttaactat     5760

gcggcatcag agcagattgt actgagagtg caccatatgc ggtgtgaaat accgcacaga     5820

tgcgtaagga gaaaataccg catcagattg gctattgg                             5858


<210>  17
<211>  5852
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  17
cctggccatt gcatacgttg tatccatatc ataatatgta catttatatt ggctcatgtc       60

caacattacc gccatgttga cattgattat tgactagtta ttaatagtaa tcaattacgg      120

ggtcattagt tcatagccca tatatggagt tccgcgttac ataacttacg gtaaatggcc      180

cgcctggctg accgcccaac gacccccgcc cattgacgtc aataatgacg tatgttccca      240

tagtaacgcc aatagggact ttccattgac gtcaatgggt ggagtattta cggtaaactg      300

cccacttggc agtacatcaa gtgtatcata tgccaagtac gccccctatt gacgtcaatg      360

atggtaaatg gcccgcctgg cattatgccc agtacatgac cttatgggac tttcctactt      420

ggcagtacat ctacgtatta gtcatcgcta ttaccatggt gatgcggttt tggcagtaca      480

tcaatgggcg tggatagcgg tttgactcac ggggatttcc aagtctccac cccattgacg      540

tcaatgggag tttgttttgg caccaaaatc aacgggactt tccaaaatgt cgtaacaact      600

ccgccccatt gacgcaaatg ggcggtaggc gtgtacggtg ggaggtctat ataagcagag      660

ctcgtttagt gaaccgtcag atcgcctgga gacgccatcc acgctgtttt gacctccata      720

gaagacaccg ggaccgatcc agcctccgcg ggcgcgcgtc gaggaattcg ctagcaagaa      780

atggccccga ggcgggcgcg aggctgccgg accctcggtc tcccggcgct gctactgctc      840

ctgctgctcc ggccgccggc gacgcggggc atcacgtgcc cgccccccat gtccgtggag      900

cacgcagaca tctgggtcaa gagctacagc ttgtactccc gggagcggta catctgcaac      960

tcgggtttca agcggaaggc cggcacgtcc agcctgacgg agtgcgtgtt gaacaaggcc     1020

acgaatgtcg cccactggac gaccccctcg ctcaagtgca tccgcgaccc ggccctggtt     1080

caccagcggc ccgcgccacc ctccaccgta acgacggcgg gggtgacccc gcagccggag     1140

agcctctccc cgtcgggaaa ggagcccgcc gcgtcgtcgc ccagctcgaa caacacggcg     1200

gccacaactg cagcgatcgt cccgggctcc cagctgatgc cgtcgaagtc gccgtccacg     1260

ggaaccacgg agatcagcag tcatgagtcc tcccacggca ccccctcgca aacgacggcc     1320

aagaactggg aactcacggc gtccgcctcc caccagccgc cgggggtgta tccgcacagc     1380

gacaccacgg tggcgatctc cacgtccacg gtcctgctgt gtgggctgag cgcggtgtcg     1440

ctcctggcgt gctacctcaa gtcgaggcag actcccccgc tggccagcgt tgagatggag     1500

gccatggagg ctctgccggt gacgtggggg accagcagca gggatgagga cttggagaac     1560

tgctcgcacc acctataatg agaattcacg cgtggatctg atatcggatc tgctgtgcct     1620

tctagttgcc agccatctgt tgtttgcccc tcccccgtgc cttccttgac cctggaaggt     1680

gccactccca ctgtcctttc ctaataaaat gaggaaattg catcgcattg tctgagtagg     1740

tgtcattcta ttctgggggg tggggtgggg caggacagca agggggagga ttgggaagac     1800

aatagcaggc atgctgggga tgcggtgggc tctatgggta cccaggtgct gaagaattga     1860

cccggttcct cctgggccag aaagaagcag gcacatcccc ttctctgtga cacaccctgt     1920

ccacgcccct ggttcttagt tccagcccca ctcataggac actcatagct caggagggct     1980

ccgccttcaa tcccacccgc taaagtactt ggagcggtct ctccctccct catcagccca     2040

ccaaaccaaa cctagcctcc aagagtggga agaaattaaa gcaagatagg ctattaagtg     2100

cagagggaga gaaaatgcct ccaacatgtg aggaagtaat gagagaaatc atagaatttc     2160

ttccgcttcc tcgctcactg actcgctgcg ctcggtcgtt cggctgcggc gagcggtatc     2220

agctcactca aaggcggtaa tacggttatc cacagaatca ggggataacg caggaaagaa     2280

catgtgagca aaaggccagc aaaaggccag gaaccgtaaa aaggccgcgt tgctggcgtt     2340

tttccatagg ctccgccccc ctgacgagca tcacaaaaat cgacgctcaa gtcagaggtg     2400

gcgaaacccg acaggactat aaagatacca ggcgtttccc cctggaagct ccctcgtgcg     2460

ctctcctgtt ccgaccctgc cgcttaccgg atacctgtcc gcctttctcc cttcgggaag     2520

cgtggcgctt tctcatagct cacgctgtag gtatctcagt tcggtgtagg tcgttcgctc     2580

caagctgggc tgtgtgcacg aaccccccgt tcagcccgac cgctgcgcct tatccggtaa     2640

ctatcgtctt gagtccaacc cggtaagaca cgacttatcg ccactggcag cagccactgg     2700

taacaggatt agcagagcga ggtatgtagg cggtgctaca gagttcttga agtggtggcc     2760

taactacggc tacactagaa gaacagtatt tggtatctgc gctctgctga agccagttac     2820

cttcggaaaa agagttggta gctcttgatc cggcaaacaa accaccgctg gtagcggtgg     2880

tttttttgtt tgcaagcagc agattacgcg cagaaaaaaa ggatctcaag aagatccttt     2940

gatcttttct acggggtctg acgctcagtg gaacgaaaac tcacgttaag ggattttggt     3000

catgagatta tcaaaaagga tcttcaccta gatcctttta aattaaaaat gaagttttaa     3060

atcaatctaa agtatatatg agtaaacttg gtctgacagt taccaatgct taatcagtga     3120

ggcacctatc tcagcgatct gtctatttcg ttcatccata gttgcctgac tcgggggggg     3180

ggggcgctga ggtctgcctc gtgaagaagg tgttgctgac tcataccagg cctgaatcgc     3240

cccatcatcc agccagaaag tgagggagcc acggttgatg agagctttgt tgtaggtgga     3300

ccagttggtg attttgaact tttgctttgc cacggaacgg tctgcgttgt cgggaagatg     3360

cgtgatctga tccttcaact cagcaaaagt tcgatttatt caacaaagcc gccgtcccgt     3420

caagtcagcg taatgctctg ccagtgttac aaccaattaa ccaattctga ttagaaaaac     3480

tcatcgagca tcaaatgaaa ctgcaattta ttcatatcag gattatcaat accatatttt     3540

tgaaaaagcc gtttctgtaa tgaaggagaa aactcaccga ggcagttcca taggatggca     3600

agatcctggt atcggtctgc gattccgact cgtccaacat caatacaacc tattaatttc     3660

ccctcgtcaa aaataaggtt atcaagtgag aaatcaccat gagtgacgac tgaatccggt     3720

gagaatggca aaagcttatg catttctttc cagacttgtt caacaggcca gccattacgc     3780

tcgtcatcaa aatcactcgc atcaaccaaa ccgttattca ttcgtgattg cgcctgagcg     3840

agacgaaata cgcgatcgct gttaaaagga caattacaaa caggaatcga atgcaaccgg     3900

cgcaggaaca ctgccagcgc atcaacaata ttttcacctg aatcaggata ttcttctaat     3960

acctggaatg ctgttttccc ggggatcgca gtggtgagta accatgcatc atcaggagta     4020

cggataaaat gcttgatggt cggaagaggc ataaattccg tcagccagtt tagtctgacc     4080

atctcatctg taacatcatt ggcaacgcta cctttgccat gtttcagaaa caactctggc     4140

gcatcgggct tcccatacaa tcgatagatt gtcgcacctg attgcccgac attatcgcga     4200

gcccatttat acccatataa atcagcatcc atgttggaat ttaatcgcgg cctcgagcaa     4260

gacgtttccc gttgaatatg gctcataaca ccccttgtat tactgtttat gtaagcagac     4320

agttttattg ttcatgatga tatattttta tcttgtgcaa tgtaacatca gagattttga     4380

gacacaacgt ggatcatcca gacatgataa gatacattga tgagtttgga caaaccacaa     4440

ctagaatgca gtgaaaaaaa tgctttattt gtgaaatttg tgatgctatt gctttatttg     4500

taaccattat aagctgcaat aaacaagtta acaacaacaa ttgcattcat tttatgtttc     4560

aggttcaggg ggaggtgtgg gaggtttttt aaagcaagta aaacctctac aaatgtggta     4620

tggctgatta tgatcgtcga ggatctggat ccgttaaccg atatccgcga attcggcgcg     4680

ccgggccctc acgacgtgtt gatgaacatc tggacgatgt gcacgaacga ctgcaggaac     4740

tccttgatgt tcttctcctc cagctcctcg cactccttgc agcccgactc cgtgacgttc     4800

ccgttcgacg acagcgagtt gttcgccagg atgatcaggt tctccaccgt gtcgtggatc     4860

gacgcgtccc ccgactcgag cgagatgact tggagctcca ggaggaagca cttcatcgcc     4920

gtgaccttgc acgacgggtg gacgtccgac tccgtgtaca gcgtcgcgtc gatgtgcatc     4980

gactggatga ggtcctcgat cttcttcagg tccgagatca cgttcaccca gttcgagatg     5040

ctgcaggcca ccgtccccag gagtagcagg ctctggagcc acatttcttg tcgacagatc     5100

caaacgctcc tccgacgtcc ccaggcagaa tggcggttcc ctaaacgagc attgcttata     5160

tagacctccc attaggcacg cctaccgccc atttacgtca atggaacgcc catttgcgtc     5220

attgcccctc cccattgacg tcaatgggga tgtacttggc agccatcgcg ggccatttac     5280

cgccattgac gtcaatggga gtactgccaa tgtaccctgg cgtacttcca atagtaatgt     5340

acttgccaag ttactattaa tagatattga tgtactgcca agtgggccat ttaccgtcat     5400

tgacgtcaat agggggcgtg agaacggata tgaatgggca atgagccatc ccattgacgt     5460

caatggtggg tggtcctatt gacgtcaatg ggcattgagc caggcgggcc atttaccgta     5520

attgacgtca atgggggagg cgccatatac gtcaatagga ccgcccatat gacgtcaata     5580

ggtaagacca tgaggccctt tcgtctcgcg cgtttcggtg atgacggtga aaacctctga     5640

cacatgcagc tcccggagac ggtcacagct tgtctgtaag cggatgccgg gagcagacaa     5700

gcccgtcagg gcgcgtcagc gggtgttggc gggtgtcggg gctggcttaa ctatgcggca     5760

tcagagcaga ttgtactgag agtgcaccat atgcggtgtg aaataccgca cagatgcgta     5820

aggagaaaat accgcatcag attggctatt gg                                   5852


<210>  18
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  18

Gln Gly His Ser 
1               


<210>  19
<211>  267
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (199)..(202)
<223>  X is any naturally occurring amino acid residue or is absent

<400>  19

Met Ala Pro Arg Arg Ala Arg Gly Cys Arg Thr Leu Gly Leu Pro Ala 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Leu Arg Pro Pro Ala Thr Arg Gly Ile Thr 
            20                  25                  30          


Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val Lys Ser 
        35                  40                  45              


Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe Lys 
    50                  55                  60                  


Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn Lys Ala 
65                  70                  75                  80  


Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile Arg Asp 
                85                  90                  95      


Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Thr Val Thr Thr 
            100                 105                 110         


Ala Gly Val Thr Pro Gln Pro Glu Ser Leu Ser Pro Ser Gly Lys Glu 
        115                 120                 125             


Pro Ala Ala Ser Ser Pro Ser Ser Asn Asn Thr Ala Ala Thr Thr Ala 
    130                 135                 140                 


Ala Ile Val Pro Gly Ser Gln Leu Met Pro Ser Lys Ser Pro Ser Thr 
145                 150                 155                 160 


Gly Thr Thr Glu Ile Ser Ser His Glu Ser Ser His Gly Thr Pro Ser 
                165                 170                 175     


Gln Thr Thr Ala Lys Asn Trp Glu Leu Thr Ala Ser Ala Ser His Gln 
            180                 185                 190         


Pro Pro Gly Val Tyr Pro Xaa Xaa Xaa Xaa Asp Thr Thr Val Ala Ile 
        195                 200                 205             


Ser Thr Ser Thr Val Leu Leu Cys Gly Leu Ser Ala Val Ser Leu Leu 
    210                 215                 220                 


Ala Cys Tyr Leu Lys Ser Arg Gln Thr Pro Pro Leu Ala Ser Val Glu 
225                 230                 235                 240 


Met Glu Ala Met Glu Ala Leu Pro Val Thr Trp Gly Thr Ser Ser Arg 
                245                 250                 255     


Asp Glu Asp Leu Glu Asn Cys Ser His His Leu 
            260                 265         


<210>  20
<211>  1853
<212>  DNA
<213>  Homo sapiens

<400>  20
gccaaaggga agtgctgcga ggtttacaac cagctgcagt ggttcgatgg gaaggatctt       60

tctccaagtg gttcctcttg aggggagcat ttctgctggc tccaggactt tggccatcta      120

taaagcttgg caatgagaaa taagaaaatt ctcaaggagg acgagctctt gagtgagacc      180

caacaagctg cttttcacca aattgcaatg gagcctttcg aaatcaatgt tccaaagccc      240

aagaggagaa atggggtgaa cttctcccta gctgtggtgg tcatctacct gatcctgctc      300

accgctggcg ctgggctgct ggtggtccaa gttctgaatc tgcaggcgcg gctccgggtc      360

ctggagatgt atttcctcaa tgacactctg gcggctgagg acagcccgtc cttctccttg      420

ctgcagtcag cacaccctgg agaacacctg gctcagggtg catcgaggct gcaagtcctg      480

caggcccaac tcacctgggt ccgcgtcagc catgagcact tgctgcagcg ggtagacaac      540

ttcactcaga acccagggat gttcagaatc aaaggtgaac aaggcgcccc aggtcttcaa      600

ggtcacaagg gggccatggg catgcctggt gcccctggcc cgccgggacc acctgctgag      660

aagggagcca agggggctat gggacgagat ggagcaacag gcccctcggg accccaaggc      720

ccaccgggag tcaagggaga ggcgggcctc caaggacccc agggtgctcc agggaagcaa      780

ggagccactg gcaccccagg accccaagga gagaagggca gcaaaggcga tgggggtctc      840

attggcccaa aaggggaaac tggaactaag ggagagaaag gagacctggg tctcccagga      900

agcaaagggg acaggggcat gaaaggagat gcaggggtca tggggcctcc tggagcccag      960

gggagtaaag gtgacttcgg gaggccaggc ccaccaggtt tggctggttt tcctggagct     1020

aaaggagatc aaggacaacc tggactgcag ggtgttccgg gccctcctgg tgcagtggga     1080

cacccaggtg ccaagggtga gcctggcagt gctggctccc ctgggcgagc aggacttcca     1140

gggagccccg ggagtccagg agccacaggc ctgaaaggaa gcaaagggga cacaggactt     1200

caaggacagc aaggaagaaa aggagaatca ggagttccag gccctgcagg tgtgaaggga     1260

gaacagggga gcccagggct ggcaggtccc aagggagccc ctggacaagc tggccagaag     1320

ggagaccagg gagtgaaagg atcttctggg gagcaaggag taaagggaga aaaaggtgaa     1380

agaggtgaaa actcagtgtc cgtcaggatt gtcggcagta gtaaccgagg ccgggctgaa     1440

gtttactaca gtggtacctg ggggacaatt tgcgatgacg agtggcaaaa ttctgatgcc     1500

attgtcttct gccgcatgct gggttactcc aaaggaaggg ccctgtacaa agtgggagct     1560

ggcactgggc agatctggct ggataatgtt cagtgtcggg gcacggagag taccctgtgg     1620

agctgcacca agaatagctg gggccatcat gactgcagcc acgaggagga cgcaggcgtg     1680

gagtgcagcg tctgacccgg aaaccctttc acttctctgc tcccgaggtg tcctcgggct     1740

catatgtggg aaggcagagg atctctgagg agttccctgg ggacaactga gcagcctctg     1800

gagaggggcc attaataaag ctcaacatca ttggcaaaaa aaaaaaaaaa aaa            1853


<210>  21
<211>  520
<212>  PRT
<213>  Homo sapiens

<400>  21

Met Arg Asn Lys Lys Ile Leu Lys Glu Asp Glu Leu Leu Ser Glu Thr 
1               5                   10                  15      


Gln Gln Ala Ala Phe His Gln Ile Ala Met Glu Pro Phe Glu Ile Asn 
            20                  25                  30          


Val Pro Lys Pro Lys Arg Arg Asn Gly Val Asn Phe Ser Leu Ala Val 
        35                  40                  45              


Val Val Ile Tyr Leu Ile Leu Leu Thr Ala Gly Ala Gly Leu Leu Val 
    50                  55                  60                  


Val Gln Val Leu Asn Leu Gln Ala Arg Leu Arg Val Leu Glu Met Tyr 
65                  70                  75                  80  


Phe Leu Asn Asp Thr Leu Ala Ala Glu Asp Ser Pro Ser Phe Ser Leu 
                85                  90                  95      


Leu Gln Ser Ala His Pro Gly Glu His Leu Ala Gln Gly Ala Ser Arg 
            100                 105                 110         


Leu Gln Val Leu Gln Ala Gln Leu Thr Trp Val Arg Val Ser His Glu 
        115                 120                 125             


His Leu Leu Gln Arg Val Asp Asn Phe Thr Gln Asn Pro Gly Met Phe 
    130                 135                 140                 


Arg Ile Lys Gly Glu Gln Gly Ala Pro Gly Leu Gln Gly His Lys Gly 
145                 150                 155                 160 


Ala Met Gly Met Pro Gly Ala Pro Gly Pro Pro Gly Pro Pro Ala Glu 
                165                 170                 175     


Lys Gly Ala Lys Gly Ala Met Gly Arg Asp Gly Ala Thr Gly Pro Ser 
            180                 185                 190         


Gly Pro Gln Gly Pro Pro Gly Val Lys Gly Glu Ala Gly Leu Gln Gly 
        195                 200                 205             


Pro Gln Gly Ala Pro Gly Lys Gln Gly Ala Thr Gly Thr Pro Gly Pro 
    210                 215                 220                 


Gln Gly Glu Lys Gly Ser Lys Gly Asp Gly Gly Leu Ile Gly Pro Lys 
225                 230                 235                 240 


Gly Glu Thr Gly Thr Lys Gly Glu Lys Gly Asp Leu Gly Leu Pro Gly 
                245                 250                 255     


Ser Lys Gly Asp Arg Gly Met Lys Gly Asp Ala Gly Val Met Gly Pro 
            260                 265                 270         


Pro Gly Ala Gln Gly Ser Lys Gly Asp Phe Gly Arg Pro Gly Pro Pro 
        275                 280                 285             


Gly Leu Ala Gly Phe Pro Gly Ala Lys Gly Asp Gln Gly Gln Pro Gly 
    290                 295                 300                 


Leu Gln Gly Val Pro Gly Pro Pro Gly Ala Val Gly His Pro Gly Ala 
305                 310                 315                 320 


Lys Gly Glu Pro Gly Ser Ala Gly Ser Pro Gly Arg Ala Gly Leu Pro 
                325                 330                 335     


Gly Ser Pro Gly Ser Pro Gly Ala Thr Gly Leu Lys Gly Ser Lys Gly 
            340                 345                 350         


Asp Thr Gly Leu Gln Gly Gln Gln Gly Arg Lys Gly Glu Ser Gly Val 
        355                 360                 365             


Pro Gly Pro Ala Gly Val Lys Gly Glu Gln Gly Ser Pro Gly Leu Ala 
    370                 375                 380                 


Gly Pro Lys Gly Ala Pro Gly Gln Ala Gly Gln Lys Gly Asp Gln Gly 
385                 390                 395                 400 


Val Lys Gly Ser Ser Gly Glu Gln Gly Val Lys Gly Glu Lys Gly Glu 
                405                 410                 415     


Arg Gly Glu Asn Ser Val Ser Val Arg Ile Val Gly Ser Ser Asn Arg 
            420                 425                 430         


Gly Arg Ala Glu Val Tyr Tyr Ser Gly Thr Trp Gly Thr Ile Cys Asp 
        435                 440                 445             


Asp Glu Trp Gln Asn Ser Asp Ala Ile Val Phe Cys Arg Met Leu Gly 
    450                 455                 460                 


Tyr Ser Lys Gly Arg Ala Leu Tyr Lys Val Gly Ala Gly Thr Gly Gln 
465                 470                 475                 480 


Ile Trp Leu Asp Asn Val Gln Cys Arg Gly Thr Glu Ser Thr Leu Trp 
                485                 490                 495     


Ser Cys Thr Lys Asn Ser Trp Gly His His Asp Cys Ser His Glu Glu 
            500                 505                 510         


Asp Ala Gly Val Glu Cys Ser Val 
        515                 520 


<210>  22
<211>  5363
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  22
cctggccatt gcatacgttg tatccatatc ataatatgta catttatatt ggctcatgtc       60

caacattacc gccatgttga cattgattat tgactagtta ttaatagtaa tcaattacgg      120

ggtcattagt tcatagccca tatatggagt tccgcgttac ataacttacg gtaaatggcc      180

cgcctggctg accgcccaac gacccccgcc cattgacgtc aataatgacg tatgttccca      240

tagtaacgcc aatagggact ttccattgac gtcaatgggt ggagtattta cggtaaactg      300

cccacttggc agtacatcaa gtgtatcata tgccaagtac gccccctatt gacgtcaatg      360

atggtaaatg gcccgcctgg cattatgccc agtacatgac cttatgggac tttcctactt      420

ggcagtacat ctacgtatta gtcatcgcta ttaccatggt gatgcggttt tggcagtaca      480

tcaatgggcg tggatagcgg tttgactcac ggggatttcc aagtctccac cccattgacg      540

tcaatgggag tttgttttgg caccaaaatc aacgggactt tccaaaatgt cgtaacaact      600

ccgccccatt gacgcaaatg ggcggtaggc gtgtacggtg ggaggtctat ataagcagag      660

ctcgtttagt gaaccgtcag atcgcctgga gacgccatcc acgctgtttt gacctccata      720

gaagacaccg ggaccgatcc agcctccgcg ggcgcgcgtc gaggaattct ctagaaagaa      780

atgtggctcc agaacctgct attcctgggg atcgtggtct acagcctctc gaactggatc      840

gatgtgcgct acgacctgga gaagatcgag tccctcatcc agtcgatcca catcgacacc      900

acgctgtaca cggactcgga cttccacccg tcgtgcaagg tcacggcgat gaactgcttc      960

ctcctggagc tgcaagtcat cctgcacgag tactcgaaca tgaccctcaa cgagacggtg     1020

cgcaacgtgc tgtacctggc gaactcgacc ctgtcgtcga acaagaacgt cgccgagtcg     1080

ggctgcaagg agtgcgagga gctggaggag aagaccttca cggagttcct gcagtcgttc     1140

atccgcatcg tccagatgtt catcaacacg tcgatgtggg agctggagaa ggacgtctac     1200

gtcgtggagg tggactggac gcccgacgcc cccggggaga cggtgaacct cacctgcgac     1260

acgccggagg aggacgacat cacctggacc agcgaccagc ggcacggcgt catcggcagc     1320

ggcaagaccc tgacgatcac cgtcaaggag ttcctcgacg ccggccagta cacctgccac     1380

aagggcggcg agacgctgag ccacagccac ctgctgctcc acaagaagga gaacggcatc     1440

tggtccaccg agatcctcaa gaacttcaag aacaagacct tcctgaagtg cgaggcgccc     1500

aactactccg gccggttcac gtgctcctgg ctggtgcagc gcaacatgga cctcaagttc     1560

aacatcaagt cgtccagcag ttcccccgac tcccgggcgg tgacctgcgg catggcgtcc     1620

ctgtcggcgg agaaggtcac gctggaccag agggactacg agaagtactc ggtgtcctgc     1680

caggaggacg tcacctgccc cacggccgag gagaccctgc ccatcgagct ggcgctggag     1740

gcccggcagc agaacaagta cgagaactac agcaccagct tcttcatccg ggacatcatc     1800

aagcccgacc cgcccaagaa cctgcagatg aagcccctga agaacagcca ggtggaggtc     1860

agctgggagt acccggactc ctggagcacg ccccactcct acttcagcct gaagttcttc     1920

gtcagaatcc agcgcaagaa agagaagatg aaggagacgg aggaggggtg caaccagaag     1980

ggcgcgttcc tcgtcgagaa gacctccacc gaggtccagt gcaagggcgg gaacgtctgc     2040

gtgcaggctc aggaccgcta ctacaactcc agctgcagca agtgggcctg cgtcccctgc     2100

agggtccggt cctagtaaag atctgatatc ggatctgctg tgccttctag ttgccagcca     2160

tctgttgttt gcccctcccc cgtgccttcc ttgaccctgg aaggtgccac tcccactgtc     2220

ctttcctaat aaaatgagga aattgcatcg cattgtctga gtaggtgtca ttctattctg     2280

gggggtgggg tggggcagga cagcaagggg gaggattggg aagacaatag caggcatgct     2340

ggggatgcgg tgggctctat gggtacccag gtgctgaaga attgacccgg ttcctcctgg     2400

gccagaaaga agcaggcaca tccccttctc tgtgacacac cctgtccacg cccctggttc     2460

ttagttccag ccccactcat aggacactca tagctcagga gggctccgcc ttcaatccca     2520

cccgctaaag tacttggagc ggtctctccc tccctcatca gcccaccaaa ccaaacctag     2580

cctccaagag tgggaagaaa ttaaagcaag ataggctatt aagtgcagag ggagagaaaa     2640

tgcctccaac atgtgaggaa gtaatgagag aaatcataga atttcttccg cttcctcgct     2700

cactgactcg ctgcgctcgg tcgttcggct gcggcgagcg gtatcagctc actcaaaggc     2760

ggtaatacgg ttatccacag aatcagggga taacgcagga aagaacatgt gagcaaaagg     2820

ccagcaaaag gccaggaacc gtaaaaaggc cgcgttgctg gcgtttttcc ataggctccg     2880

cccccctgac gagcatcaca aaaatcgacg ctcaagtcag aggtggcgaa acccgacagg     2940

actataaaga taccaggcgt ttccccctgg aagctccctc gtgcgctctc ctgttccgac     3000

cctgccgctt accggatacc tgtccgcctt tctcccttcg ggaagcgtgg cgctttctca     3060

tagctcacgc tgtaggtatc tcagttcggt gtaggtcgtt cgctccaagc tgggctgtgt     3120

gcacgaaccc cccgttcagc ccgaccgctg cgccttatcc ggtaactatc gtcttgagtc     3180

caacccggta agacacgact tatcgccact ggcagcagcc actggtaaca ggattagcag     3240

agcgaggtat gtaggcggtg ctacagagtt cttgaagtgg tggcctaact acggctacac     3300

tagaagaaca gtatttggta tctgcgctct gctgaagcca gttaccttcg gaaaaagagt     3360

tggtagctct tgatccggca aacaaaccac cgctggtagc ggtggttttt ttgtttgcaa     3420

gcagcagatt acgcgcagaa aaaaaggatc tcaagaagat cctttgatct tttctacggg     3480

gtctgacgct cagtggaacg aaaactcacg ttaagggatt ttggtcatga gattatcaaa     3540

aaggatcttc acctagatcc ttttaaatta aaaatgaagt tttaaatcaa tctaaagtat     3600

atatgagtaa acttggtctg acagttacca atgcttaatc agtgaggcac ctatctcagc     3660

gatctgtcta tttcgttcat ccatagttgc ctgactcggg gggggggggc gctgaggtct     3720

gcctcgtgaa gaaggtgttg ctgactcata ccaggcctga atcgccccat catccagcca     3780

gaaagtgagg gagccacggt tgatgagagc tttgttgtag gtggaccagt tggtgatttt     3840

gaacttttgc tttgccacgg aacggtctgc gttgtcggga agatgcgtga tctgatcctt     3900

caactcagca aaagttcgat ttattcaaca aagccgccgt cccgtcaagt cagcgtaatg     3960

ctctgccagt gttacaacca attaaccaat tctgattaga aaaactcatc gagcatcaaa     4020

tgaaactgca atttattcat atcaggatta tcaataccat atttttgaaa aagccgtttc     4080

tgtaatgaag gagaaaactc accgaggcag ttccatagga tggcaagatc ctggtatcgg     4140

tctgcgattc cgactcgtcc aacatcaata caacctatta atttcccctc gtcaaaaata     4200

aggttatcaa gtgagaaatc accatgagtg acgactgaat ccggtgagaa tggcaaaagc     4260

ttatgcattt ctttccagac ttgttcaaca ggccagccat tacgctcgtc atcaaaatca     4320

ctcgcatcaa ccaaaccgtt attcattcgt gattgcgcct gagcgagacg aaatacgcga     4380

tcgctgttaa aaggacaatt acaaacagga atcgaatgca accggcgcag gaacactgcc     4440

agcgcatcaa caatattttc acctgaatca ggatattctt ctaatacctg gaatgctgtt     4500

ttcccgggga tcgcagtggt gagtaaccat gcatcatcag gagtacggat aaaatgcttg     4560

atggtcggaa gaggcataaa ttccgtcagc cagtttagtc tgaccatctc atctgtaaca     4620

tcattggcaa cgctaccttt gccatgtttc agaaacaact ctggcgcatc gggcttccca     4680

tacaatcgat agattgtcgc acctgattgc ccgacattat cgcgagccca tttataccca     4740

tataaatcag catccatgtt ggaatttaat cgcggcctcg agcaagacgt ttcccgttga     4800

atatggctca taacacccct tgtattactg tttatgtaag cagacagttt tattgttcat     4860

gatgatatat ttttatcttg tgcaatgtaa catcagagat tttgagacac aacgtggctt     4920

tccccccccc cccattattg aagcatttat cagggttatt gtctcatgag cggatacata     4980

tttgaatgta tttagaaaaa taaacaaata ggggttccgc gcacatttcc ccgaaaagtg     5040

ccacctgacg tctaagaaac cattattatc atgacattaa cctataaaaa taggcgtatc     5100

acgaggccct ttcgtctcgc gcgtttcggt gatgacggtg aaaacctctg acacatgcag     5160

ctcccggaga cggtcacagc ttgtctgtaa gcggatgccg ggagcagaca agcccgtcag     5220

ggcgcgtcag cgggtgttgg cgggtgtcgg ggctggctta actatgcggc atcagagcag     5280

attgtactga gagtgcacca tatgcggtgt gaaataccgc acagatgcgt aaggagaaaa     5340

taccgcatca gattggctat tgg                                             5363


<210>  23
<211>  444
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  23

Met Trp Leu Gln Asn Leu Leu Phe Leu Gly Ile Val Val Tyr Ser Leu 
1               5                   10                  15      


Ser Asn Trp Ile Asp Val Arg Tyr Asp Leu Glu Lys Ile Glu Ser Leu 
            20                  25                  30          


Ile Gln Ser Ile His Ile Asp Thr Thr Leu Tyr Thr Asp Ser Asp Phe 
        35                  40                  45              


His Pro Ser Cys Lys Val Thr Ala Met Asn Cys Phe Leu Leu Glu Leu 
    50                  55                  60                  


Gln Val Ile Leu His Glu Tyr Ser Asn Met Thr Leu Asn Glu Thr Val 
65                  70                  75                  80  


Arg Asn Val Leu Tyr Leu Ala Asn Ser Thr Leu Ser Ser Asn Lys Asn 
                85                  90                  95      


Val Ala Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Thr 
            100                 105                 110         


Phe Thr Glu Phe Leu Gln Ser Phe Ile Arg Ile Val Gln Met Phe Ile 
        115                 120                 125             


Asn Thr Ser Met Trp Glu Leu Glu Lys Asp Val Tyr Val Val Glu Val 
    130                 135                 140                 


Asp Trp Thr Pro Asp Ala Pro Gly Glu Thr Val Asn Leu Thr Cys Asp 
145                 150                 155                 160 


Thr Pro Glu Glu Asp Asp Ile Thr Trp Thr Ser Asp Gln Arg His Gly 
                165                 170                 175     


Val Ile Gly Ser Gly Lys Thr Leu Thr Ile Thr Val Lys Glu Phe Leu 
            180                 185                 190         


Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Thr Leu Ser His 
        195                 200                 205             


Ser His Leu Leu Leu His Lys Lys Glu Asn Gly Ile Trp Ser Thr Glu 
    210                 215                 220                 


Ile Leu Lys Asn Phe Lys Asn Lys Thr Phe Leu Lys Cys Glu Ala Pro 
225                 230                 235                 240 


Asn Tyr Ser Gly Arg Phe Thr Cys Ser Trp Leu Val Gln Arg Asn Met 
                245                 250                 255     


Asp Leu Lys Phe Asn Ile Lys Ser Ser Ser Ser Ser Pro Asp Ser Arg 
            260                 265                 270         


Ala Val Thr Cys Gly Met Ala Ser Leu Ser Ala Glu Lys Val Thr Leu 
        275                 280                 285             


Asp Gln Arg Asp Tyr Glu Lys Tyr Ser Val Ser Cys Gln Glu Asp Val 
    290                 295                 300                 


Thr Cys Pro Thr Ala Glu Glu Thr Leu Pro Ile Glu Leu Ala Leu Glu 
305                 310                 315                 320 


Ala Arg Gln Gln Asn Lys Tyr Glu Asn Tyr Ser Thr Ser Phe Phe Ile 
                325                 330                 335     


Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Met Lys Pro 
            340                 345                 350         


Leu Lys Asn Ser Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Ser Trp 
        355                 360                 365             


Ser Thr Pro His Ser Tyr Phe Ser Leu Lys Phe Phe Val Arg Ile Gln 
    370                 375                 380                 


Arg Lys Lys Glu Lys Met Lys Glu Thr Glu Glu Gly Cys Asn Gln Lys 
385                 390                 395                 400 


Gly Ala Phe Leu Val Glu Lys Thr Ser Thr Glu Val Gln Cys Lys Gly 
                405                 410                 415     


Gly Asn Val Cys Val Gln Ala Gln Asp Arg Tyr Tyr Asn Ser Ser Cys 
            420                 425                 430         


Ser Lys Trp Ala Cys Val Pro Cys Arg Val Arg Ser 
        435                 440                 


<210>  24
<211>  5375
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  24
cctggccatt gcatacgttg tatccatatc ataatatgta catttatatt ggctcatgtc       60

caacattacc gccatgttga cattgattat tgactagtta ttaatagtaa tcaattacgg      120

ggtcattagt tcatagccca tatatggagt tccgcgttac ataacttacg gtaaatggcc      180

cgcctggctg accgcccaac gacccccgcc cattgacgtc aataatgacg tatgttccca      240

tagtaacgcc aatagggact ttccattgac gtcaatgggt ggagtattta cggtaaactg      300

cccacttggc agtacatcaa gtgtatcata tgccaagtac gccccctatt gacgtcaatg      360

atggtaaatg gcccgcctgg cattatgccc agtacatgac cttatgggac tttcctactt      420

ggcagtacat ctacgtatta gtcatcgcta ttaccatggt gatgcggttt tggcagtaca      480

tcaatgggcg tggatagcgg tttgactcac ggggatttcc aagtctccac cccattgacg      540

tcaatgggag tttgttttgg caccaaaatc aacgggactt tccaaaatgt cgtaacaact      600

ccgccccatt gacgcaaatg ggcggtaggc gtgtacggtg ggaggtctat ataagcagag      660

ctcgtttagt gaaccgtcag atcgcctgga gacgccatcc acgctgtttt gacctccata      720

gaagacaccg ggaccgatcc agcctccgcg ggcgcgcgtc gaggaattct ctagaaagaa      780

atgtggctcc agaacctgct attcctgggg atcgtggtct acagcctctc gaactggatc      840

gatgtgcgct acgacctgga gaagatcgag tccctcatcc agtcgatcca catcgacacc      900

acgctgtaca cggactcgga cttccacccg tcgtgcaagg tcacggcgat gaactgcttc      960

ctcctggagc tgcaagtcat cctgcacgag tactcgaaca tgaccctcaa cgagacggtg     1020

cgcaacgtgc tgtacctggc gaactcgacc ctgtcgtcga acaagaacgt cgccgagtcg     1080

ggctgcaagg agtgcgagga gctggaggag aagaccttca cggagttcct gcagtcgttc     1140

atccgcatcg tccagatgtt catcaacacg tcgggagcag gtgctatgtg ggagctggag     1200

aaggacgtct acgtcgtgga ggtggactgg acgcccgacg cccccgggga gacggtgaac     1260

ctcacctgcg acacgccgga ggaggacgac atcacctgga ccagcgacca gcggcacggc     1320

gtcatcggca gcggcaagac cctgacgatc accgtcaagg agttcctcga cgccggccag     1380

tacacctgcc acaagggcgg cgagacgctg agccacagcc acctgctgct ccacaagaag     1440

gagaacggca tctggtccac cgagatcctc aagaacttca agaacaagac cttcctgaag     1500

tgcgaggcgc ccaactactc cggccggttc acgtgctcct ggctggtgca gcgcaacatg     1560

gacctcaagt tcaacatcaa gtcgtccagc agttcccccg actcccgggc ggtgacctgc     1620

ggcatggcgt ccctgtcggc ggagaaggtc acgctggacc agagggacta cgagaagtac     1680

tcggtgtcct gccaggagga cgtcacctgc cccacggccg aggagaccct gcccatcgag     1740

ctggcgctgg aggcccggca gcagaacaag tacgagaact acagcaccag cttcttcatc     1800

cgggacatca tcaagcccga cccgcccaag aacctgcaga tgaagcccct gaagaacagc     1860

caggtggagg tcagctggga gtacccggac tcctggagca cgccccactc ctacttcagc     1920

ctgaagttct tcgtcagaat ccagcgcaag aaagagaaga tgaaggagac ggaggagggg     1980

tgcaaccaga agggcgcgtt cctcgtcgag aagacctcca ccgaggtcca gtgcaagggc     2040

gggaacgtct gcgtgcaggc tcaggaccgc tactacaact ccagctgcag caagtgggcc     2100

tgcgtcccct gcagggtccg gtcctagtaa agatctgata tcggatctgc tgtgccttct     2160

agttgccagc catctgttgt ttgcccctcc cccgtgcctt ccttgaccct ggaaggtgcc     2220

actcccactg tcctttccta ataaaatgag gaaattgcat cgcattgtct gagtaggtgt     2280

cattctattc tggggggtgg ggtggggcag gacagcaagg gggaggattg ggaagacaat     2340

agcaggcatg ctggggatgc ggtgggctct atgggtaccc aggtgctgaa gaattgaccc     2400

ggttcctcct gggccagaaa gaagcaggca catccccttc tctgtgacac accctgtcca     2460

cgcccctggt tcttagttcc agccccactc ataggacact catagctcag gagggctccg     2520

ccttcaatcc cacccgctaa agtacttgga gcggtctctc cctccctcat cagcccacca     2580

aaccaaacct agcctccaag agtgggaaga aattaaagca agataggcta ttaagtgcag     2640

agggagagaa aatgcctcca acatgtgagg aagtaatgag agaaatcata gaatttcttc     2700

cgcttcctcg ctcactgact cgctgcgctc ggtcgttcgg ctgcggcgag cggtatcagc     2760

tcactcaaag gcggtaatac ggttatccac agaatcaggg gataacgcag gaaagaacat     2820

gtgagcaaaa ggccagcaaa aggccaggaa ccgtaaaaag gccgcgttgc tggcgttttt     2880

ccataggctc cgcccccctg acgagcatca caaaaatcga cgctcaagtc agaggtggcg     2940

aaacccgaca ggactataaa gataccaggc gtttccccct ggaagctccc tcgtgcgctc     3000

tcctgttccg accctgccgc ttaccggata cctgtccgcc tttctccctt cgggaagcgt     3060

ggcgctttct catagctcac gctgtaggta tctcagttcg gtgtaggtcg ttcgctccaa     3120

gctgggctgt gtgcacgaac cccccgttca gcccgaccgc tgcgccttat ccggtaacta     3180

tcgtcttgag tccaacccgg taagacacga cttatcgcca ctggcagcag ccactggtaa     3240

caggattagc agagcgaggt atgtaggcgg tgctacagag ttcttgaagt ggtggcctaa     3300

ctacggctac actagaagaa cagtatttgg tatctgcgct ctgctgaagc cagttacctt     3360

cggaaaaaga gttggtagct cttgatccgg caaacaaacc accgctggta gcggtggttt     3420

ttttgtttgc aagcagcaga ttacgcgcag aaaaaaagga tctcaagaag atcctttgat     3480

cttttctacg gggtctgacg ctcagtggaa cgaaaactca cgttaaggga ttttggtcat     3540

gagattatca aaaaggatct tcacctagat ccttttaaat taaaaatgaa gttttaaatc     3600

aatctaaagt atatatgagt aaacttggtc tgacagttac caatgcttaa tcagtgaggc     3660

acctatctca gcgatctgtc tatttcgttc atccatagtt gcctgactcg gggggggggg     3720

gcgctgaggt ctgcctcgtg aagaaggtgt tgctgactca taccaggcct gaatcgcccc     3780

atcatccagc cagaaagtga gggagccacg gttgatgaga gctttgttgt aggtggacca     3840

gttggtgatt ttgaactttt gctttgccac ggaacggtct gcgttgtcgg gaagatgcgt     3900

gatctgatcc ttcaactcag caaaagttcg atttattcaa caaagccgcc gtcccgtcaa     3960

gtcagcgtaa tgctctgcca gtgttacaac caattaacca attctgatta gaaaaactca     4020

tcgagcatca aatgaaactg caatttattc atatcaggat tatcaatacc atatttttga     4080

aaaagccgtt tctgtaatga aggagaaaac tcaccgaggc agttccatag gatggcaaga     4140

tcctggtatc ggtctgcgat tccgactcgt ccaacatcaa tacaacctat taatttcccc     4200

tcgtcaaaaa taaggttatc aagtgagaaa tcaccatgag tgacgactga atccggtgag     4260

aatggcaaaa gcttatgcat ttctttccag acttgttcaa caggccagcc attacgctcg     4320

tcatcaaaat cactcgcatc aaccaaaccg ttattcattc gtgattgcgc ctgagcgaga     4380

cgaaatacgc gatcgctgtt aaaaggacaa ttacaaacag gaatcgaatg caaccggcgc     4440

aggaacactg ccagcgcatc aacaatattt tcacctgaat caggatattc ttctaatacc     4500

tggaatgctg ttttcccggg gatcgcagtg gtgagtaacc atgcatcatc aggagtacgg     4560

ataaaatgct tgatggtcgg aagaggcata aattccgtca gccagtttag tctgaccatc     4620

tcatctgtaa catcattggc aacgctacct ttgccatgtt tcagaaacaa ctctggcgca     4680

tcgggcttcc catacaatcg atagattgtc gcacctgatt gcccgacatt atcgcgagcc     4740

catttatacc catataaatc agcatccatg ttggaattta atcgcggcct cgagcaagac     4800

gtttcccgtt gaatatggct cataacaccc cttgtattac tgtttatgta agcagacagt     4860

tttattgttc atgatgatat atttttatct tgtgcaatgt aacatcagag attttgagac     4920

acaacgtggc tttccccccc cccccattat tgaagcattt atcagggtta ttgtctcatg     4980

agcggataca tatttgaatg tatttagaaa aataaacaaa taggggttcc gcgcacattt     5040

ccccgaaaag tgccacctga cgtctaagaa accattatta tcatgacatt aacctataaa     5100

aataggcgta tcacgaggcc ctttcgtctc gcgcgtttcg gtgatgacgg tgaaaacctc     5160

tgacacatgc agctcccgga gacggtcaca gcttgtctgt aagcggatgc cgggagcaga     5220

caagcccgtc agggcgcgtc agcgggtgtt ggcgggtgtc ggggctggct taactatgcg     5280

gcatcagagc agattgtact gagagtgcac catatgcggt gtgaaatacc gcacagatgc     5340

gtaaggagaa aataccgcat cagattggct attgg                                5375


<210>  25
<211>  448
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  25

Met Trp Leu Gln Asn Leu Leu Phe Leu Gly Ile Val Val Tyr Ser Leu 
1               5                   10                  15      


Ser Asn Trp Ile Asp Val Arg Tyr Asp Leu Glu Lys Ile Glu Ser Leu 
            20                  25                  30          


Ile Gln Ser Ile His Ile Asp Thr Thr Leu Tyr Thr Asp Ser Asp Phe 
        35                  40                  45              


His Pro Ser Cys Lys Val Thr Ala Met Asn Cys Phe Leu Leu Glu Leu 
    50                  55                  60                  


Gln Val Ile Leu His Glu Tyr Ser Asn Met Thr Leu Asn Glu Thr Val 
65                  70                  75                  80  


Arg Asn Val Leu Tyr Leu Ala Asn Ser Thr Leu Ser Ser Asn Lys Asn 
                85                  90                  95      


Val Ala Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Thr 
            100                 105                 110         


Phe Thr Glu Phe Leu Gln Ser Phe Ile Arg Ile Val Gln Met Phe Ile 
        115                 120                 125             


Asn Thr Ser Gly Ala Gly Ala Met Trp Glu Leu Glu Lys Asp Val Tyr 
    130                 135                 140                 


Val Val Glu Val Asp Trp Thr Pro Asp Ala Pro Gly Glu Thr Val Asn 
145                 150                 155                 160 


Leu Thr Cys Asp Thr Pro Glu Glu Asp Asp Ile Thr Trp Thr Ser Asp 
                165                 170                 175     


Gln Arg His Gly Val Ile Gly Ser Gly Lys Thr Leu Thr Ile Thr Val 
            180                 185                 190         


Lys Glu Phe Leu Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu 
        195                 200                 205             


Thr Leu Ser His Ser His Leu Leu Leu His Lys Lys Glu Asn Gly Ile 
    210                 215                 220                 


Trp Ser Thr Glu Ile Leu Lys Asn Phe Lys Asn Lys Thr Phe Leu Lys 
225                 230                 235                 240 


Cys Glu Ala Pro Asn Tyr Ser Gly Arg Phe Thr Cys Ser Trp Leu Val 
                245                 250                 255     


Gln Arg Asn Met Asp Leu Lys Phe Asn Ile Lys Ser Ser Ser Ser Ser 
            260                 265                 270         


Pro Asp Ser Arg Ala Val Thr Cys Gly Met Ala Ser Leu Ser Ala Glu 
        275                 280                 285             


Lys Val Thr Leu Asp Gln Arg Asp Tyr Glu Lys Tyr Ser Val Ser Cys 
    290                 295                 300                 


Gln Glu Asp Val Thr Cys Pro Thr Ala Glu Glu Thr Leu Pro Ile Glu 
305                 310                 315                 320 


Leu Ala Leu Glu Ala Arg Gln Gln Asn Lys Tyr Glu Asn Tyr Ser Thr 
                325                 330                 335     


Ser Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu 
            340                 345                 350         


Gln Met Lys Pro Leu Lys Asn Ser Gln Val Glu Val Ser Trp Glu Tyr 
        355                 360                 365             


Pro Asp Ser Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Lys Phe Phe 
    370                 375                 380                 


Val Arg Ile Gln Arg Lys Lys Glu Lys Met Lys Glu Thr Glu Glu Gly 
385                 390                 395                 400 


Cys Asn Gln Lys Gly Ala Phe Leu Val Glu Lys Thr Ser Thr Glu Val 
                405                 410                 415     


Gln Cys Lys Gly Gly Asn Val Cys Val Gln Ala Gln Asp Arg Tyr Tyr 
            420                 425                 430         


Asn Ser Ser Cys Ser Lys Trp Ala Cys Val Pro Cys Arg Val Arg Ser 
        435                 440                 445             


