                         SEQUENCE LISTING

<110>  Board of Regents, The University of Texas System
       STCube, Inc.
 
<120>  COMBINATION TREATMENTS DIRECTED TOWARD PROGRAMMED DEATH LIGAND-1 
       (PD-L1) POSITIVE CANCERS

<130>  UTFC.P1255WO

<140>  PCT/US17/25539
<141>  2017-03-31

<150>  US 62/316,178
<151>  2016-03-31

<160>  59    

<170>  PatentIn version 3.5

<210>  1
<211>  290
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Arg Ile Phe Ala Val Phe Ile Phe Met Thr Tyr Trp His Leu Leu 
1               5                   10                  15      


Asn Ala Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr 
            20                  25                  30          


Gly Ser Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu 
        35                  40                  45              


Asp Leu Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile 
    50                  55                  60                  


Ile Gln Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser 
65                  70                  75                  80  


Tyr Arg Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn 
                85                  90                  95      


Ala Ala Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr 
            100                 105                 110         


Arg Cys Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val 
        115                 120                 125             


Lys Val Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val 
    130                 135                 140                 


Asp Pro Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr 
145                 150                 155                 160 


Pro Lys Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser 
                165                 170                 175     


Gly Lys Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn 
            180                 185                 190         


Val Thr Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr 
        195                 200                 205             


Cys Thr Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu 
    210                 215                 220                 


Val Ile Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr His 
225                 230                 235                 240 


Leu Val Ile Leu Gly Ala Ile Leu Leu Cys Leu Gly Val Ala Leu Thr 
                245                 250                 255     


Phe Ile Phe Arg Leu Arg Lys Gly Arg Met Met Asp Val Lys Lys Cys 
            260                 265                 270         


Gly Ile Gln Asp Thr Asn Ser Lys Lys Gln Ser Asp Thr His Leu Glu 
        275                 280                 285             


Glu Thr 
    290 


<210>  2
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  2
tcaattgtca tattgctac                                                    19


<210>  3
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  3
ttgactccat ctttcttca                                                    19


<210>  4
<211>  39
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer

<400>  4
gtggtagagt atggtagcca aatgacaatt gaatgcaaa                              39


<210>  5
<211>  39
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer

<400>  5
tttgcattca attgtcattt ggctaccata ctctaccac                              39


<210>  6
<211>  37
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer

<400>  6
gagaggagaa gcttttccag gtgaccagca cactgag                                37


<210>  7
<211>  37
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer

<400>  7
ctcagtgtgc tggtcacctg gaaaagcttc tcctctc                                37


<210>  8
<211>  39
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer

<400>  8
gaccagcaca ctgagaatcc agacaacaac taatgagat                              39


<210>  9
<211>  39
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer

<400>  9
atctcattag ttgttgtctg gattctcagt gtgctggtc                              39


<210>  10
<211>  40
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer

<400>  10
gagagaggag aagcttttcc aagtgaccag cacactgaga                             40


<210>  11
<211>  40
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer

<400>  11
tctcagtgtg ctggtcactt ggaaaagctt ctcctctctc                             40


<210>  12
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer

<400>  12
gcataacgaa cctaaccctc ag                                                22


<210>  13
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer

<400>  13
gcccaatgtc cactgtgata                                                   20


<210>  14
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer

<400>  14
gtaacctcag tcacctgcc                                                    19


<210>  15
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer

<400>  15
attccgctcc acaatctctg                                                   20


<210>  16
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer

<400>  16
tcttcaacct cacgctcaag                                                   20


<210>  17
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer

<400>  17
gtgtgcaaag acgtcatcat c                                                 21


<210>  18
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer

<400>  18
caccatcacc ctcctttcta ttc                                               23


<210>  19
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer

<400>  19
gaacaacagg tctgggattt ct                                                22


<210>  20
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer

<400>  20
gccttttgcc atcgacatg                                                    19


<210>  21
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer

<400>  21
agtcagattc ttgcatccct g                                                 21


<210>  22
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer

<400>  22
caaggagagc attaggacca ag                                                22


<210>  23
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer

<400>  23
ccccattaaa cctcaggact g                                                 21


<210>  24
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer

<400>  24
tcgtcatggt gtggtattcc                                                   20


<210>  25
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer

<400>  25
caggaagatg ggctgatcc                                                    19


<210>  26
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer

<400>  26
gaccgcactc atcttacacc                                                   20


<210>  27
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer

<400>  27
ggaggttggc tgaaggaata c                                                 21


<210>  28
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer

<400>  28
tcccctgctt taaccatcg                                                    19


<210>  29
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer

<400>  29
ttgtcaccta tactggcgtt g                                                 21


<210>  30
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer

<400>  30
ctgagtgatg gaacgagtga g                                                 21


<210>  31
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer

<400>  31
tagagatgac cagatgcaac g                                                 21


<210>  32
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer

<400>  32
gagtccaact tcacggctta t                                                 21


<210>  33
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer

<400>  33
agtggtccag gaagacatag a                                                 21


<210>  34
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer

<400>  34
tgtgagggaa agatcaagtg g                                                 21


<210>  35
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer

<400>  35
gctctccaag gtaaatgagg ac                                                22


<210>  36
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer

<400>  36
ccactgagtt cgtcaagagg                                                   20


<210>  37
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer

<400>  37
acttccttgc catctgtcac                                                   20


<210>  38
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer

<400>  38
tggctcgctg ataagttctg                                                   20


<210>  39
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer

<400>  39
gtgagtctgg tttgggagaa g                                                 21


<210>  40
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer

<400>  40
gcaaagacct gtacgccaac a                                                 21


<210>  41
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer

<400>  41
tgcatcctgt cggcaatg                                                     18


<210>  42
<211>  53
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic consensus peptide


<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (32)..(32)
<223>  Xaa can be any naturally occurring amino acid

<400>  42

Ala Phe Thr Ile Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly 
1               5                   10                  15      


Ser Asn Val Thr Xaa Glu Cys Arg Phe Pro Val Glu Lys Gln Leu Xaa 
            20                  25                  30          


Leu Leu Ala Leu Val Val Tyr Trp Glu Met Glu Asp Lys Lys Ile Ile 
        35                  40                  45              


Gln Phe Val Asn Gly 
    50              


<210>  43
<211>  53
<212>  PRT
<213>  Homo sapiens

<400>  43

Ala Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly 
1               5                   10                  15      


Ser Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Pro Leu Asp 
            20                  25                  30          


Leu Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile 
        35                  40                  45              


Gln Phe Val His Gly 
    50              


<210>  44
<211>  53
<212>  PRT
<213>  Mus musculus

<400>  44

Ala Phe Thr Ile Thr Ala Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly 
1               5                   10                  15      


Ser Asn Val Thr Met Glu Cys Arg Phe Pro Val Glu Arg Glu Leu Asp 
            20                  25                  30          


Leu Leu Ala Leu Val Val Tyr Trp Glu Lys Glu Asp Glu Gln Val Ile 
        35                  40                  45              


Pro Phe Val Ala Gly 
    50              


<210>  45
<211>  53
<212>  PRT
<213>  Rattus norvegicus

<400>  45

Ala Phe Thr Ile Thr Ala Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly 
1               5                   10                  15      


Ser Asn Val Thr Met Glu Cys Arg Phe Pro Val Glu Gln Lys Leu Asp 
            20                  25                  30          


Leu Leu Ala Leu Val Val Tyr Trp Glu Lys Glu Asp Lys Glu Val Ile 
        35                  40                  45              


Gln Phe Val Glu Gly 
    50              


<210>  46
<211>  53
<212>  PRT
<213>  Bos taurus

<400>  46

Ala Phe Thr Ile Thr Val Ser Lys Asp Leu Tyr Val Val Glu Tyr Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Arg Phe Pro Val Asp Lys Gln Leu Asn 
            20                  25                  30          


Leu Leu Val Leu Val Val Tyr Trp Glu Met Glu Asp Lys Lys Ile Ile 
        35                  40                  45              


Gln Phe Val Asn Gly 
    50              


<210>  47
<211>  53
<212>  PRT
<213>  Sus scrofa

<400>  47

Ala Phe Thr Ile Thr Val Pro Lys Asp Met Tyr Glu Val Glu Tyr Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Arg Phe Pro Val Asp Lys Gln Leu Asn 
            20                  25                  30          


Leu Leu Ala Leu Val Val Tyr Trp Glu Met Lys Asp Lys Lys Ile Ile 
        35                  40                  45              


Gln Phe Val Asn Gly 
    50              


<210>  48
<211>  53
<212>  PRT
<213>  Equus caballus

<400>  48

Ala Phe Thr Ile Thr Val Thr Lys Asp Leu Tyr Val Val Asp Tyr Gly 
1               5                   10                  15      


Ser Asn Val Thr Ile Glu Cys Lys Phe Pro Val Glu Glu Pro Leu Asn 
            20                  25                  30          


Leu Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asn Lys Lys Ile Ile 
        35                  40                  45              


Gln Phe Val Asn Gly 
    50              


<210>  49
<211>  53
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic consensus peptide


<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (44)..(46)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (48)..(48)
<223>  Xaa can be any naturally occurring amino acid

<400>  49

Glu Lys Leu Phe Asn Val Thr Ser Thr Leu Arg Xaa Asn Ala Thr Ala 
1               5                   10                  15      


Asn Glu Ile Phe Tyr Cys Thr Phe Arg Arg Ile Gly Pro Glu Glu Asn 
            20                  25                  30          


His Thr Ala Glu Leu Val Ile Pro Glu Ile Pro Xaa Xaa Xaa Pro Xaa 
        35                  40                  45              


Asn Lys Arg Thr His 
    50              


<210>  50
<211>  53
<212>  PRT
<213>  Homo sapiens

<400>  50

Glu Lys Leu Phe Asn Val Thr Ser Thr Leu Arg Ile Asn Thr Thr Thr 
1               5                   10                  15      


Asn Glu Ile Phe Tyr Cys Thr Phe Arg Arg Leu Asp Pro Glu Glu Asn 
            20                  25                  30          


His Thr Ala Glu Leu Val Ile Pro Glu Leu Pro Leu Ala His Pro Pro 
        35                  40                  45              


Asn Glu Arg Thr His 
    50              


<210>  51
<211>  53
<212>  PRT
<213>  Mus musculus

<400>  51

Gly Met Leu Leu Asn Val Thr Ser Ser Leu Arg Val Asn Ala Thr Ala 
1               5                   10                  15      


Asn Asp Val Phe Tyr Cys Thr Phe Trp Arg Ser Gln Pro Gly Gln Asn 
            20                  25                  30          


His Thr Ala Glu Leu Ile Ile Pro Glu Leu Pro Ala Thr His Pro Pro 
        35                  40                  45              


Gln Asn Arg Thr His 
    50              


<210>  52
<211>  53
<212>  PRT
<213>  Rattus norvegicus

<400>  52

Glu Lys Leu Leu Asn Val Thr Ser Val Leu Arg Val Asn Ala Thr Ala 
1               5                   10                  15      


Asn Asp Val Phe His Cys Thr Phe Trp Arg Val His Ser Gly Glu Asn 
            20                  25                  30          


His Thr Ala Glu Leu Ile Ile Pro Glu Leu Pro Val Pro Arg Leu Pro 
        35                  40                  45              


His Asn Arg Thr His 
    50              


<210>  53
<211>  52
<212>  PRT
<213>  Bos taurus

<400>  53

Glu Lys Leu Phe Asn Val Thr Ser Thr Leu Arg Ile Asn Thr Thr Ala 
1               5                   10                  15      


Asp Lys Ile Phe Tyr Cys Thr Phe Arg Arg Leu Gly His Glu Glu Asn 
            20                  25                  30          


Asn Thr Ala Glu Leu Val Ile Pro Glu Pro Tyr Leu Asp Pro Ala Lys 
        35                  40                  45              


Lys Arg Asn His 
    50          


<210>  54
<211>  52
<212>  PRT
<213>  Sus scrofa

<400>  54

Glu Lys Leu Phe Asn Val Thr Ser Thr Leu Arg Val Asn Ala Thr Thr 
1               5                   10                  15      


Asn Glu Ile Phe Tyr Cys Thr Phe Arg Arg Leu Gly Pro Glu Glu Asn 
            20                  25                  30          


Ser Thr Ala Val Leu Val Ile Pro Glu Pro Tyr Val Asp Pro Ala Arg 
        35                  40                  45              


Lys Arg Thr His 
    50          


<210>  55
<211>  52
<212>  PRT
<213>  Equus caballus

<400>  55

Glu Lys Leu Phe Asn Val Thr Ser Thr Leu Arg Ile Asn Ala Thr Ala 
1               5                   10                  15      


Asn Glu Ile Phe Tyr Cys Thr Phe Arg Arg Ser Gly Leu Glu Glu Asn 
            20                  25                  30          


Ser Thr Ala Glu Leu Val Ile Pro Glu Pro Leu Ile Val Pro Ala Asn 
        35                  40                  45              


Lys Arg Thr His 
    50          


<210>  56
<211>  23
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  56

Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Ile Glu Cys 
1               5                   10                  15      


Lys Phe Pro Val Glu Lys Gln 
            20              


<210>  57
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  57

Lys Leu Phe Asn Val Thr Ser Thr Leu Arg Ile 
1               5                   10      


<210>  58
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  58

Arg Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr Phe Arg Arg 
1               5                   10                  15  


<210>  59
<211>  28
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  59

Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile Pro 
1               5                   10                  15      


Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr 
            20                  25              


