                         SEQUENCE LISTING

<110>  The Schepens Eye Research Institute, Inc.
       D'Amore, Patricia A
       Saint-Geniez, Magali
       Park-Windhol, Cindy
 
<120>  ENDOMUCIN INHIBITOR AS AN ANTI-ANGIOGENIC AGENT

<130>  36770-552001WO

<150>  62/316,481
<151>  2016-03-31

<160>  7     

<170>  PatentIn version 3.5

<210>  1
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA sequence

<400>  1
ugguuuacau gucgacuaa                                                    19


<210>  2
<211>  261
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Glu Leu Leu Gln Val Thr Ile Leu Phe Leu Leu Pro Ser Ile Cys 
1               5                   10                  15      


Ser Ser Asn Ser Thr Gly Val Leu Glu Ala Ala Asn Asn Ser Leu Val 
            20                  25                  30          


Val Thr Thr Thr Lys Pro Ser Ile Thr Thr Pro Asn Thr Glu Ser Leu 
        35                  40                  45              


Gln Lys Asn Val Val Thr Pro Thr Thr Gly Thr Thr Pro Lys Gly Thr 
    50                  55                  60                  


Ile Thr Asn Glu Leu Leu Lys Met Ser Leu Met Ser Thr Ala Thr Phe 
65                  70                  75                  80  


Leu Thr Ser Lys Asp Glu Gly Leu Lys Ala Thr Thr Thr Asp Val Arg 
                85                  90                  95      


Lys Asn Asp Ser Ile Ile Ser Asn Val Thr Val Thr Ser Val Thr Leu 
            100                 105                 110         


Pro Asn Ala Val Ser Thr Leu Gln Ser Ser Lys Pro Lys Thr Glu Thr 
        115                 120                 125             


Gln Ser Ser Ile Lys Thr Thr Glu Ile Pro Gly Ser Val Leu Gln Pro 
    130                 135                 140                 


Asp Ala Ser Pro Ser Lys Thr Gly Thr Leu Thr Ser Ile Pro Val Thr 
145                 150                 155                 160 


Ile Pro Glu Asn Thr Ser Gln Ser Gln Val Ile Gly Thr Glu Gly Gly 
                165                 170                 175     


Lys Asn Ala Ser Thr Ser Ala Thr Ser Arg Ser Tyr Ser Ser Ile Ile 
            180                 185                 190         


Leu Pro Val Val Ile Ala Leu Ile Val Ile Thr Leu Ser Val Phe Val 
        195                 200                 205             


Leu Val Gly Leu Tyr Arg Met Cys Trp Lys Ala Asp Pro Gly Thr Pro 
    210                 215                 220                 


Glu Asn Gly Asn Asp Gln Pro Gln Ser Asp Lys Glu Ser Val Lys Leu 
225                 230                 235                 240 


Leu Thr Val Lys Thr Ile Ser His Glu Ser Gly Glu His Ser Ala Gln 
                245                 250                 255     


Gly Lys Thr Lys Asn 
            260     


<210>  3
<211>  4047
<212>  DNA
<213>  Homo sapiens

<400>  3
gggagtgtgt gtatttcctc ccgttcttta tcagagcccc caaaataagt aggaatgggc       60

agtggctatt cacattcact acaccttttc catttgctaa taaggccctg ccaggctggg      120

agggaattgt ccctgcctgc ttctggagaa agaagatatt gacaccatct acgggcacca      180

tggaactgct tcaagtgacc attctttttc ttctgcccag tatttgcagc agtaacagca      240

caggtgtttt agaggcagct aataattcac ttgttgttac tacaacaaaa ccatctataa      300

caacaccaaa cacagaatca ttacagaaaa atgttgtcac accaacaact ggaacaactc      360

ctaaaggaac aatcaccaat gaattactta aaatgtctct gatgtcaaca gctacttttt      420

taacaagtaa agatgaagga ttgaaagcca caaccactga tgtcaggaag aatgactcca      480

tcatttcaaa cgtaacagta acaagtgtta cacttccaaa tgctgtttca acattacaaa      540

gttccaaacc caagactgaa actcagagtt caattaaaac aacagaaata ccaggtagtg      600

ttctacaacc agatgcatca ccttctaaaa ctggtacatt aacctcaata ccagttacaa      660

ttccagaaaa cacctcacag tctcaagtaa taggcactga gggtggaaaa aatgcaagca      720

cttcagcaac cagccggtct tattccagta ttattttgcc ggtggttatt gctttgattg      780

taataacact ttcagtattt gttctggtgg gtttgtaccg aatgtgctgg aaggcagatc      840

cgggcacacc agaaaatgga aatgatcaac ctcagtctga taaagagagc gtgaagcttc      900

ttaccgttaa gacaatttct catgagtctg gtgagcactc tgcacaagga aaaaccaaga      960

actgacagct tgaggaattc tctccacacc taggcaataa ttacgcttaa tcttcagctt     1020

ctatgcacca agcgtggaaa aggagaaagt cctgcagaat caatcccgac ttccatacct     1080

gctgctggac tgtaccagac gtctgtccca gtaaagtgat gtccagctga catgcaataa     1140

tttgatggaa tcaaaaagaa ccccggggct ctcctgttct ctcacattta aaaattccat     1200

tactccattt acaggagcgt tcctaggaaa aggaatttta ggaggagaat ttgtgagcag     1260

tgaatctgac agcccaggag gtgggctcgc tgataggcat gactttcctt aatgtttaaa     1320

gttttccggg ccaagaattt ttatccatga agactttcct acttttctca gtgttcttat     1380

attacctact gttagtattt attgtttacc actatgttaa tgcagggaaa agttgcacgt     1440

gtattattaa atattaggta gaaatcatac catgctactt tgtacatata agtattttat     1500

tcctgctttc gtgttacttt taataaataa ctactgtact caatactcta aaaatactat     1560

aacatgactg tgaaaatggc aatgttattg tcttcctata attatgaata tttttggatg     1620

gattattaga atacatgaac tcactaatga aaggcatttg taataagtca gaaagggaca     1680

tacgattcac atatcagact gttaggggga gagtaattta tcagttcttt ggtctttcta     1740

tttgtcattc atactatgtg atgaagatgt aagtgcaagg gcatttataa cactatactg     1800

cattcattaa gataatagga tcatgatttt tcattaactc atttgattga tattatctcc     1860

atgcattttt tatttctttt agaaatgtaa ttatttgctc tagcaatcat tgctaacctc     1920

tagtttgtag aaaatcaaca ctttataaat acataattat gatattattt ttcattgtat     1980

cactgttcta aaaataccat atgattatag ctgccactcc atcaggagca aattcttctg     2040

ttaaaagcta actgatcaac cttgaccact tttttgacat gtgagatcaa agtgtcaagt     2100

tggctgaggt tttttggaaa gctttagaac taataagctg ctggtggcag ctttgtaacg     2160

tatgattatc taagctgatt ttgatgctaa attatcttag tgatctaagg ggcagtttag     2220

tgaagatgga atcttgtatt taaaatagcc ttttaaaatt tgttttgtgg tgatgtattt     2280

tgacaacttc catctttagg agttatataa tcaccttgat tttagtttcc tgatgtttgg     2340

actatttata atcaaggaca ccaagcaagc ataagcatat ctatatttct gactggtgtc     2400

tctttgagaa ggatgggaag tagaaaaaaa aaaaagaaag aaaggaaagg aagagaggag     2460

agaagaaggc agggatctcc actatgtatg ttttcacttt agaactgttg agcccatgct     2520

taattttaat ctagaagtct ttaaatggtg agacagtgac tggagcatgc caatcagaga     2580

gcatttgtct tcagaaaaaa aaaaaatctg agtttgagac tagcctggcc aacatgttga     2640

aaccccatat ctactaaaaa tacaaaaatt agcctggtgt ggtggcgcac gcctgtagtc     2700

ccagctactc tggagcctga ggaacgtgaa tcgcttgaac ccagaagaca gaggttgcag     2760

tgagctgaga tggcactatt gcactccagc ctgggtgaca cagcaagact ctgtctcaaa     2820

aaaaaaaaaa aaaaaaagga aaaaaaagaa agaaagaaag tcccagcaca cctagataat     2880

ttaccgagct cttcagcaaa aaccatgtta catacagcat attccaaaga aatgaactct     2940

tctgcaattt aaattataag taatatgtta ttttggatcc tagagaaacc attttctcta     3000

catttcatga gcatggttag aaaagagttt acaagaatta ggaagaggga acaattttaa     3060

tggtcagaaa agaataaaat ttattctagt tcaagaagtg cacacaaaga atatgcatta     3120

atctaacaac tatgagatta aatctttcaa aaaggtcaaa ggaggattga gaagtttaca     3180

gagatgtcca cggcatttta tatcaatctc aaaggtaagg tctgcatttt tataaaccaa     3240

cttaaacttc tgttgagata ggatattttg ttttcaagcc aaaattacca ttaatcaaat     3300

atgttttaat tatctgattt agatgatcta ctttttatgc ctggcttact gtaagttttt     3360

tattctgata cacagttcaa acatcattgc aacaaagaag tgcctgtatt tagatcaaag     3420

gcaagacttt ctatgtgttt gttttgcata ataatatgaa tataatttaa gtctatcaat     3480

agtcaaaaca taaacaaaag ctaattaact ggcactgttg tcacctgaga ctaagtggat     3540

gttgttggct gacatacagg ctcagccagc agagaaagaa ttctgaattc cccttgctga     3600

actgaactat tctgttacat atggttgaca aatctgtgtg ttatttcttt tctacctacc     3660

atatttaaat ttatgagtat caaccgagga catagtcaaa ccttcgatga tgaacattcc     3720

tgattttttg cctgattatt ctctgttgag ctctacttgt ggtcattcaa gattttatga     3780

tgttgaaagg aaaagtgaat atgaccttta aaaattgtat tttgggtgat gatagtctca     3840

ccactataaa actgtcaatt attgcctaat gttaaagata tccatcattg tgattaatta     3900

aacctataat gagtattctt aatggagaat tcttaatgga tggattatcc cctgatcttt     3960

tctttaaaat ttctctgcac acacaggact tctcattttc caataaatgg gtgtactctg     4020

ccccaatttc tagggaaaaa aaaaaaa                                         4047


<210>  4
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA sequence

<400>  4
gcgugaagcu ucuuaccgu                                                    19


<210>  5
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA sequence

<400>  5
aggcaauaau uacgcuuaa                                                    19


<210>  6
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA sequence

<400>  6
ggaaaaguug cacguguau                                                    19


<210>  7
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA sequence

<400>  7
caucauuuca aacguaaca                                                    19


