                         SEQUENCE LISTING

<110>  REGENTS OF THE UNIVERSITY OF CALIFORNIA
       SHEPPARD, DEAN
       SUNDARAM, APARNA
       DEGRADO, WILLIAM F.
       JO, HYUNIL
       MCINTOSH, JOEL
 
<120>  INHIBITORS OF INTEGRIN ALPHA 5 BETA 1 AND METHODS OF USE

<130>  48536-584001WO

<140>  PCT/US2017/025432
<141>  2017-03-31

<150>  US 62/317,422
<151>  2016-04-01

<160>  7     

<170>  PatentIn version 3.5

<210>  1
<211>  3
<212>  PRT
<213>  Homo sapiens

<400>  1

Arg Gly Asp 
1           


<210>  2
<211>  3
<212>  PRT
<213>  Homo sapiens

<400>  2

Asp Gly Arg 
1           


<210>  3
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  3

Gly Arg Gly Asp Ser Pro 
1               5       


<210>  4
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  4

Cys Asn Thr Leu Lys Gly Asp Cys 
1               5               


<210>  5
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  5

Asn Thr Leu Lys Gly Asp 
1               5       


<210>  6
<211>  1098
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Pro Pro Arg Gln Pro Pro Arg Gln Ala Gly Gly Gly Leu Ser Arg 
1               5                   10                  15      


Glu Phe Gly Lys Leu Leu Pro Ala Leu Ser His Ser Pro Leu Gly Gly 
            20                  25                  30          


Leu Gly Ser Gly Ser Gly Ser Val Ala Pro Gly Gln Gly Arg Ala Gly 
        35                  40                  45              


Ala Met Gly Ser Arg Thr Pro Glu Ser Pro Leu His Ala Val Gln Leu 
    50                  55                  60                  


Arg Trp Gly Pro Arg Arg Arg Pro Pro Leu Leu Pro Leu Leu Leu Leu 
65                  70                  75                  80  


Leu Leu Pro Pro Pro Pro Arg Val Gly Gly Phe Asn Leu Asp Ala Glu 
                85                  90                  95      


Ala Pro Ala Val Leu Ser Gly Pro Pro Gly Ser Phe Phe Gly Phe Ser 
            100                 105                 110         


Val Glu Phe Tyr Arg Pro Gly Thr Asp Gly Val Ser Val Leu Val Gly 
        115                 120                 125             


Ala Pro Lys Ala Asn Thr Ser Gln Pro Gly Val Leu Gln Gly Gly Ala 
    130                 135                 140                 


Val Tyr Leu Cys Pro Trp Gly Ala Ser Pro Thr Gln Cys Thr Pro Ile 
145                 150                 155                 160 


Glu Phe Asp Ser Lys Gly Ser Arg Leu Leu Glu Ser Ser Leu Ser Ser 
                165                 170                 175     


Ser Glu Gly Glu Glu Pro Val Glu Tyr Lys Ser Leu Gln Trp Phe Gly 
            180                 185                 190         


Ala Thr Val Arg Ala His Gly Ser Ser Ile Leu Ala Cys Ala Pro Leu 
        195                 200                 205             


Tyr Ser Trp Arg Thr Glu Lys Glu Pro Leu Ser Asp Pro Val Gly Thr 
    210                 215                 220                 


Cys Tyr Leu Ser Thr Asp Asn Phe Thr Arg Ile Leu Glu Tyr Ala Pro 
225                 230                 235                 240 


Cys Arg Ser Asp Phe Ser Trp Ala Ala Gly Gln Gly Tyr Cys Gln Gly 
                245                 250                 255     


Gly Phe Ser Ala Glu Phe Thr Lys Thr Gly Arg Val Val Leu Gly Gly 
            260                 265                 270         


Pro Gly Ser Tyr Phe Trp Gln Gly Gln Ile Leu Ser Ala Thr Gln Glu 
        275                 280                 285             


Gln Ile Ala Glu Ser Tyr Tyr Pro Glu Tyr Leu Ile Asn Leu Val Gln 
    290                 295                 300                 


Gly Gln Leu Gln Thr Arg Gln Ala Ser Ser Ile Tyr Asp Asp Ser Tyr 
305                 310                 315                 320 


Leu Gly Tyr Ser Val Ala Val Gly Glu Phe Ser Gly Asp Asp Thr Glu 
                325                 330                 335     


Asp Phe Val Ala Gly Val Pro Lys Gly Asn Leu Thr Tyr Gly Tyr Val 
            340                 345                 350         


Thr Ile Leu Asn Gly Ser Asp Ile Arg Ser Leu Tyr Asn Phe Ser Gly 
        355                 360                 365             


Glu Gln Met Ala Ser Tyr Phe Gly Tyr Ala Val Ala Ala Thr Asp Val 
    370                 375                 380                 


Asn Gly Asp Gly Leu Asp Asp Leu Leu Val Gly Ala Pro Leu Leu Met 
385                 390                 395                 400 


Asp Arg Thr Pro Asp Gly Arg Pro Gln Glu Val Gly Arg Val Tyr Val 
                405                 410                 415     


Tyr Leu Gln His Pro Ala Gly Ile Glu Pro Thr Pro Thr Leu Thr Leu 
            420                 425                 430         


Thr Gly His Asp Glu Phe Gly Arg Phe Gly Ser Ser Leu Thr Pro Leu 
        435                 440                 445             


Gly Asp Leu Asp Gln Asp Gly Tyr Asn Asp Val Ala Ile Gly Ala Pro 
    450                 455                 460                 


Phe Gly Gly Glu Thr Gln Gln Gly Val Val Phe Val Phe Pro Gly Gly 
465                 470                 475                 480 


Pro Gly Gly Leu Gly Ser Lys Pro Ser Gln Val Leu Gln Pro Leu Trp 
                485                 490                 495     


Ala Ala Ser His Thr Pro Asp Phe Phe Gly Ser Ala Leu Arg Gly Gly 
            500                 505                 510         


Arg Asp Leu Asp Gly Asn Gly Tyr Pro Asp Leu Ile Val Gly Ser Phe 
        515                 520                 525             


Gly Val Asp Lys Ala Val Val Tyr Arg Gly Arg Pro Ile Val Ser Ala 
    530                 535                 540                 


Ser Ala Ser Leu Thr Ile Phe Pro Ala Met Phe Asn Pro Glu Glu Arg 
545                 550                 555                 560 


Ser Cys Ser Leu Glu Gly Asn Pro Val Ala Cys Ile Asn Leu Ser Phe 
                565                 570                 575     


Cys Leu Asn Ala Ser Gly Lys His Val Ala Asp Ser Ile Gly Phe Thr 
            580                 585                 590         


Val Glu Leu Gln Leu Asp Trp Gln Lys Gln Lys Gly Gly Val Arg Arg 
        595                 600                 605             


Ala Leu Phe Leu Ala Ser Arg Gln Ala Thr Leu Thr Gln Thr Leu Leu 
    610                 615                 620                 


Ile Gln Asn Gly Ala Arg Glu Asp Cys Arg Glu Met Lys Ile Tyr Leu 
625                 630                 635                 640 


Arg Asn Glu Ser Glu Phe Arg Asp Lys Leu Ser Pro Ile His Ile Ala 
                645                 650                 655     


Leu Asn Phe Ser Leu Asp Pro Gln Ala Pro Val Asp Ser His Gly Leu 
            660                 665                 670         


Arg Pro Ala Leu His Tyr Gln Ser Lys Ser Arg Ile Glu Asp Lys Ala 
        675                 680                 685             


Gln Ile Leu Leu Asp Cys Gly Glu Asp Asn Ile Cys Val Pro Asp Leu 
    690                 695                 700                 


Gln Leu Glu Val Phe Gly Glu Gln Asn His Val Tyr Leu Gly Asp Lys 
705                 710                 715                 720 


Asn Ala Leu Asn Leu Thr Phe His Ala Gln Asn Val Gly Glu Gly Gly 
                725                 730                 735     


Ala Tyr Glu Ala Glu Leu Arg Val Thr Ala Pro Pro Glu Ala Glu Tyr 
            740                 745                 750         


Ser Gly Leu Val Arg His Pro Gly Asn Phe Ser Ser Leu Ser Cys Asp 
        755                 760                 765             


Tyr Phe Ala Val Asn Gln Ser Arg Leu Leu Val Cys Asp Leu Gly Asn 
    770                 775                 780                 


Pro Met Lys Ala Gly Ala Ser Leu Trp Gly Gly Leu Arg Phe Thr Val 
785                 790                 795                 800 


Pro His Leu Arg Asp Thr Lys Lys Thr Ile Gln Phe Asp Phe Gln Ile 
                805                 810                 815     


Leu Ser Lys Asn Leu Asn Asn Ser Gln Ser Asp Val Val Ser Phe Arg 
            820                 825                 830         


Leu Ser Val Glu Ala Gln Ala Gln Val Thr Leu Asn Gly Val Ser Lys 
        835                 840                 845             


Pro Glu Ala Val Leu Phe Pro Val Ser Asp Trp His Pro Arg Asp Gln 
    850                 855                 860                 


Pro Gln Lys Glu Glu Asp Leu Gly Pro Ala Val His His Val Tyr Glu 
865                 870                 875                 880 


Leu Ile Asn Gln Gly Pro Ser Ser Ile Ser Gln Gly Val Leu Glu Leu 
                885                 890                 895     


Ser Cys Pro Gln Ala Leu Glu Gly Gln Gln Leu Leu Tyr Val Thr Arg 
            900                 905                 910         


Val Thr Gly Leu Asn Cys Thr Thr Asn His Pro Ile Asn Pro Lys Gly 
        915                 920                 925             


Leu Glu Leu Asp Pro Glu Gly Ser Leu His His Gln Gln Lys Arg Glu 
    930                 935                 940                 


Ala Pro Ser Arg Ser Ser Ala Ser Ser Gly Pro Gln Ile Leu Lys Cys 
945                 950                 955                 960 


Pro Glu Ala Glu Cys Phe Arg Leu Arg Cys Glu Leu Gly Pro Leu His 
                965                 970                 975     


Gln Gln Glu Ser Gln Ser Leu Gln Leu His Phe Arg Val Trp Ala Lys 
            980                 985                 990         


Thr Phe Leu Gln Arg Glu His Gln  Pro Phe Ser Leu Gln  Cys Glu Ala 
        995                 1000                 1005             


Val Tyr  Lys Ala Leu Lys Met  Pro Tyr Arg Ile Leu  Pro Arg Gln 
    1010                 1015                 1020             


Leu Pro  Gln Lys Glu Arg Gln  Val Ala Thr Ala Val  Gln Trp Thr 
    1025                 1030                 1035             


Lys Ala  Glu Gly Ser Tyr Gly  Val Pro Leu Trp Ile  Ile Ile Leu 
    1040                 1045                 1050             


Ala Ile  Leu Phe Gly Leu Leu  Leu Leu Gly Leu Leu  Ile Tyr Ile 
    1055                 1060                 1065             


Leu Tyr  Lys Leu Gly Phe Phe  Lys Arg Ser Leu Pro  Tyr Gly Thr 
    1070                 1075                 1080             


Ala Met  Glu Lys Ala Gln Leu  Lys Pro Pro Ala Thr  Ser Asp Ala 
    1085                 1090                 1095             


<210>  7
<211>  798
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Asn Leu Gln Pro Ile Phe Trp Ile Gly Leu Ile Ser Ser Val Cys 
1               5                   10                  15      


Cys Val Phe Ala Gln Thr Asp Glu Asn Arg Cys Leu Lys Ala Asn Ala 
            20                  25                  30          


Lys Ser Cys Gly Glu Cys Ile Gln Ala Gly Pro Asn Cys Gly Trp Cys 
        35                  40                  45              


Thr Asn Ser Thr Phe Leu Gln Glu Gly Met Pro Thr Ser Ala Arg Cys 
    50                  55                  60                  


Asp Asp Leu Glu Ala Leu Lys Lys Lys Gly Cys Pro Pro Asp Asp Ile 
65                  70                  75                  80  


Glu Asn Pro Arg Gly Ser Lys Asp Ile Lys Lys Asn Lys Asn Val Thr 
                85                  90                  95      


Asn Arg Ser Lys Gly Thr Ala Glu Lys Leu Lys Pro Glu Asp Ile Thr 
            100                 105                 110         


Gln Ile Gln Pro Gln Gln Leu Val Leu Arg Leu Arg Ser Gly Glu Pro 
        115                 120                 125             


Gln Thr Phe Thr Leu Lys Phe Lys Arg Ala Glu Asp Tyr Pro Ile Asp 
    130                 135                 140                 


Leu Tyr Tyr Leu Met Asp Leu Ser Tyr Ser Met Lys Asp Asp Leu Glu 
145                 150                 155                 160 


Asn Val Lys Ser Leu Gly Thr Asp Leu Met Asn Glu Met Arg Arg Ile 
                165                 170                 175     


Thr Ser Asp Phe Arg Ile Gly Phe Gly Ser Phe Val Glu Lys Thr Val 
            180                 185                 190         


Met Pro Tyr Ile Ser Thr Thr Pro Ala Lys Leu Arg Asn Pro Cys Thr 
        195                 200                 205             


Ser Glu Gln Asn Cys Thr Ser Pro Phe Ser Tyr Lys Asn Val Leu Ser 
    210                 215                 220                 


Leu Thr Asn Lys Gly Glu Val Phe Asn Glu Leu Val Gly Lys Gln Arg 
225                 230                 235                 240 


Ile Ser Gly Asn Leu Asp Ser Pro Glu Gly Gly Phe Asp Ala Ile Met 
                245                 250                 255     


Gln Val Ala Val Cys Gly Ser Leu Ile Gly Trp Arg Asn Val Thr Arg 
            260                 265                 270         


Leu Leu Val Phe Ser Thr Asp Ala Gly Phe His Phe Ala Gly Asp Gly 
        275                 280                 285             


Lys Leu Gly Gly Ile Val Leu Pro Asn Asp Gly Gln Cys His Leu Glu 
    290                 295                 300                 


Asn Asn Met Tyr Thr Met Ser His Tyr Tyr Asp Tyr Pro Ser Ile Ala 
305                 310                 315                 320 


His Leu Val Gln Lys Leu Ser Glu Asn Asn Ile Gln Thr Ile Phe Ala 
                325                 330                 335     


Val Thr Glu Glu Phe Gln Pro Val Tyr Lys Glu Leu Lys Asn Leu Ile 
            340                 345                 350         


Pro Lys Ser Ala Val Gly Thr Leu Ser Ala Asn Ser Ser Asn Val Ile 
        355                 360                 365             


Gln Leu Ile Ile Asp Ala Tyr Asn Ser Leu Ser Ser Glu Val Ile Leu 
    370                 375                 380                 


Glu Asn Gly Lys Leu Ser Glu Gly Val Thr Ile Ser Tyr Lys Ser Tyr 
385                 390                 395                 400 


Cys Lys Asn Gly Val Asn Gly Thr Gly Glu Asn Gly Arg Lys Cys Ser 
                405                 410                 415     


Asn Ile Ser Ile Gly Asp Glu Val Gln Phe Glu Ile Ser Ile Thr Ser 
            420                 425                 430         


Asn Lys Cys Pro Lys Lys Asp Ser Asp Ser Phe Lys Ile Arg Pro Leu 
        435                 440                 445             


Gly Phe Thr Glu Glu Val Glu Val Ile Leu Gln Tyr Ile Cys Glu Cys 
    450                 455                 460                 


Glu Cys Gln Ser Glu Gly Ile Pro Glu Ser Pro Lys Cys His Glu Gly 
465                 470                 475                 480 


Asn Gly Thr Phe Glu Cys Gly Ala Cys Arg Cys Asn Glu Gly Arg Val 
                485                 490                 495     


Gly Arg His Cys Glu Cys Ser Thr Asp Glu Val Asn Ser Glu Asp Met 
            500                 505                 510         


Asp Ala Tyr Cys Arg Lys Glu Asn Ser Ser Glu Ile Cys Ser Asn Asn 
        515                 520                 525             


Gly Glu Cys Val Cys Gly Gln Cys Val Cys Arg Lys Arg Asp Asn Thr 
    530                 535                 540                 


Asn Glu Ile Tyr Ser Gly Lys Phe Cys Glu Cys Asp Asn Phe Asn Cys 
545                 550                 555                 560 


Asp Arg Ser Asn Gly Leu Ile Cys Gly Gly Asn Gly Val Cys Lys Cys 
                565                 570                 575     


Arg Val Cys Glu Cys Asn Pro Asn Tyr Thr Gly Ser Ala Cys Asp Cys 
            580                 585                 590         


Ser Leu Asp Thr Ser Thr Cys Glu Ala Ser Asn Gly Gln Ile Cys Asn 
        595                 600                 605             


Gly Arg Gly Ile Cys Glu Cys Gly Val Cys Lys Cys Thr Asp Pro Lys 
    610                 615                 620                 


Phe Gln Gly Gln Thr Cys Glu Met Cys Gln Thr Cys Leu Gly Val Cys 
625                 630                 635                 640 


Ala Glu His Lys Glu Cys Val Gln Cys Arg Ala Phe Asn Lys Gly Glu 
                645                 650                 655     


Lys Lys Asp Thr Cys Thr Gln Glu Cys Ser Tyr Phe Asn Ile Thr Lys 
            660                 665                 670         


Val Glu Ser Arg Asp Lys Leu Pro Gln Pro Val Gln Pro Asp Pro Val 
        675                 680                 685             


Ser His Cys Lys Glu Lys Asp Val Asp Asp Cys Trp Phe Tyr Phe Thr 
    690                 695                 700                 


Tyr Ser Val Asn Gly Asn Asn Glu Val Met Val His Val Val Glu Asn 
705                 710                 715                 720 


Pro Glu Cys Pro Thr Gly Pro Asp Ile Ile Pro Ile Val Ala Gly Val 
                725                 730                 735     


Val Ala Gly Ile Val Leu Ile Gly Leu Ala Leu Leu Leu Ile Trp Lys 
            740                 745                 750         


Leu Leu Met Ile Ile His Asp Arg Arg Glu Phe Ala Lys Phe Glu Lys 
        755                 760                 765             


Glu Lys Met Asn Ala Lys Trp Asp Thr Gly Glu Asn Pro Ile Tyr Lys 
    770                 775                 780                 


Ser Ala Val Thr Thr Val Val Asn Pro Lys Tyr Glu Gly Lys 
785                 790                 795             


