                         SEQUENCE LISTING

<110>  Wake Forest University Health Sciences
       Walker, Stephen
       Krigsman, Arthur
 
<120>  IDENTIFICATION OF UNIQUE BLOOD-BASED GENE EXPRESSION PROFILES IN 
       CHILDREN WITH REGRESSIVE AUTISM SPECTRUM DISORDER (ASD) AND 
       ILEOCOLITIS

<130>  205286-7006WO1 (00050)

<150>  62/315,391
<151>  2016-03-30

<160>  18    

<170>  PatentIn version 3.5

<210>  1
<211>  2701
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ala Glu Glu Gly Ala Val Ala Val Cys Val Arg Val Arg Pro Leu 
1               5                   10                  15      


Asn Ser Arg Glu Glu Ser Leu Gly Glu Thr Ala Gln Val Tyr Trp Lys 
            20                  25                  30          


Thr Asp Asn Asn Val Ile Tyr Gln Val Asp Gly Ser Lys Ser Phe Asn 
        35                  40                  45              


Phe Asp Arg Val Phe His Gly Asn Glu Thr Thr Lys Asn Val Tyr Glu 
    50                  55                  60                  


Glu Ile Ala Ala Pro Ile Ile Asp Ser Ala Ile Gln Gly Tyr Asn Gly 
65                  70                  75                  80  


Thr Ile Phe Ala Tyr Gly Gln Thr Ala Ser Gly Lys Thr Tyr Thr Met 
                85                  90                  95      


Met Gly Ser Glu Asp His Leu Gly Val Ile Pro Arg Ala Ile His Asp 
            100                 105                 110         


Ile Phe Gln Lys Ile Lys Lys Phe Pro Asp Arg Glu Phe Leu Leu Arg 
        115                 120                 125             


Val Ser Tyr Met Glu Ile Tyr Asn Glu Thr Ile Thr Asp Leu Leu Cys 
    130                 135                 140                 


Gly Thr Gln Lys Met Lys Pro Leu Ile Ile Arg Glu Asp Val Asn Arg 
145                 150                 155                 160 


Asn Val Tyr Val Ala Asp Leu Thr Glu Glu Val Val Tyr Thr Ser Glu 
                165                 170                 175     


Met Ala Leu Lys Trp Ile Thr Lys Gly Glu Lys Ser Arg His Tyr Gly 
            180                 185                 190         


Glu Thr Lys Met Asn Gln Arg Ser Ser Arg Ser His Thr Ile Phe Arg 
        195                 200                 205             


Met Ile Leu Glu Ser Arg Glu Lys Gly Glu Pro Ser Asn Cys Glu Gly 
    210                 215                 220                 


Ser Val Lys Val Ser His Leu Asn Leu Val Asp Leu Ala Gly Ser Glu 
225                 230                 235                 240 


Arg Ala Ala Gln Thr Gly Ala Ala Gly Val Arg Leu Lys Glu Gly Cys 
                245                 250                 255     


Asn Ile Asn Arg Ser Leu Phe Ile Leu Gly Gln Val Ile Lys Lys Leu 
            260                 265                 270         


Ser Asp Gly Gln Val Gly Gly Phe Ile Asn Tyr Arg Asp Ser Lys Leu 
        275                 280                 285             


Thr Arg Ile Leu Gln Asn Ser Leu Gly Gly Asn Ala Lys Thr Arg Ile 
    290                 295                 300                 


Ile Cys Thr Ile Thr Pro Val Ser Phe Asp Glu Thr Leu Thr Ala Leu 
305                 310                 315                 320 


Gln Phe Ala Ser Thr Ala Lys Tyr Met Lys Asn Thr Pro Tyr Val Asn 
                325                 330                 335     


Glu Val Ser Thr Asp Glu Ala Leu Leu Lys Arg Tyr Arg Lys Glu Ile 
            340                 345                 350         


Met Asp Leu Lys Lys Gln Leu Glu Glu Val Ser Leu Glu Thr Arg Ala 
        355                 360                 365             


Gln Ala Met Glu Lys Asp Gln Leu Ala Gln Leu Leu Glu Glu Lys Asp 
    370                 375                 380                 


Leu Leu Gln Lys Val Gln Asn Glu Lys Ile Glu Asn Leu Thr Arg Met 
385                 390                 395                 400 


Leu Val Thr Ser Ser Ser Leu Thr Leu Gln Gln Glu Leu Lys Ala Lys 
                405                 410                 415     


Arg Lys Arg Arg Val Thr Trp Cys Leu Gly Lys Ile Asn Lys Met Lys 
            420                 425                 430         


Asn Ser Asn Tyr Ala Asp Gln Phe Asn Ile Pro Thr Asn Ile Thr Thr 
        435                 440                 445             


Lys Thr His Lys Leu Ser Ile Asn Leu Leu Arg Glu Ile Asp Glu Ser 
    450                 455                 460                 


Val Cys Ser Glu Ser Asp Val Phe Ser Asn Thr Leu Asp Thr Leu Ser 
465                 470                 475                 480 


Glu Ile Glu Trp Asn Pro Ala Thr Lys Leu Leu Asn Gln Glu Asn Ile 
                485                 490                 495     


Glu Ser Glu Leu Asn Ser Leu Arg Ala Asp Tyr Asp Asn Leu Val Leu 
            500                 505                 510         


Asp Tyr Glu Gln Leu Arg Thr Glu Lys Glu Glu Met Glu Leu Lys Leu 
        515                 520                 525             


Lys Glu Lys Asn Asp Leu Asp Glu Phe Glu Ala Leu Glu Arg Lys Thr 
    530                 535                 540                 


Lys Lys Asp Gln Glu Met Gln Leu Ile His Glu Ile Ser Asn Leu Lys 
545                 550                 555                 560 


Asn Leu Val Lys His Ala Glu Val Tyr Asn Gln Asp Leu Glu Asn Glu 
                565                 570                 575     


Leu Ser Ser Lys Val Glu Leu Leu Arg Glu Lys Glu Asp Gln Ile Lys 
            580                 585                 590         


Lys Leu Gln Glu Tyr Ile Asp Ser Gln Lys Leu Glu Asn Ile Lys Met 
        595                 600                 605             


Asp Leu Ser Tyr Ser Leu Glu Ser Ile Glu Asp Pro Lys Gln Met Lys 
    610                 615                 620                 


Gln Thr Leu Phe Asp Ala Glu Thr Val Ala Leu Asp Ala Lys Arg Glu 
625                 630                 635                 640 


Ser Ala Phe Leu Arg Ser Glu Asn Leu Glu Leu Lys Glu Lys Met Lys 
                645                 650                 655     


Glu Leu Ala Thr Thr Tyr Lys Gln Met Glu Asn Asp Ile Gln Leu Tyr 
            660                 665                 670         


Gln Ser Gln Leu Glu Ala Lys Lys Lys Met Gln Val Asp Leu Glu Lys 
        675                 680                 685             


Glu Leu Gln Ser Ala Phe Asn Glu Ile Thr Lys Leu Thr Ser Leu Ile 
    690                 695                 700                 


Asp Gly Lys Val Pro Lys Asp Leu Leu Cys Asn Leu Glu Leu Glu Gly 
705                 710                 715                 720 


Lys Ile Thr Asp Leu Gln Lys Glu Leu Asn Lys Glu Val Glu Glu Asn 
                725                 730                 735     


Glu Ala Leu Arg Glu Glu Val Ile Leu Leu Ser Glu Leu Lys Ser Leu 
            740                 745                 750         


Pro Ser Glu Val Glu Arg Leu Arg Lys Glu Ile Gln Asp Lys Ser Glu 
        755                 760                 765             


Glu Leu His Ile Ile Thr Ser Glu Lys Asp Lys Leu Phe Ser Glu Val 
    770                 775                 780                 


Val His Lys Glu Ser Arg Val Gln Gly Leu Leu Glu Glu Ile Gly Lys 
785                 790                 795                 800 


Thr Lys Asp Asp Leu Ala Thr Thr Gln Ser Asn Tyr Lys Ser Thr Asp 
                805                 810                 815     


Gln Glu Phe Gln Asn Phe Lys Thr Leu His Met Asp Phe Glu Gln Lys 
            820                 825                 830         


Tyr Lys Met Val Leu Glu Glu Asn Glu Arg Met Asn Gln Glu Ile Val 
        835                 840                 845             


Asn Leu Ser Lys Glu Ala Gln Lys Phe Asp Ser Ser Leu Gly Ala Leu 
    850                 855                 860                 


Lys Thr Glu Leu Ser Tyr Lys Thr Gln Glu Leu Gln Glu Lys Thr Arg 
865                 870                 875                 880 


Glu Val Gln Glu Arg Leu Asn Glu Met Glu Gln Leu Lys Glu Gln Leu 
                885                 890                 895     


Glu Asn Arg Asp Ser Thr Leu Gln Thr Val Glu Arg Glu Lys Thr Leu 
            900                 905                 910         


Ile Thr Glu Lys Leu Gln Gln Thr Leu Glu Glu Val Lys Thr Leu Thr 
        915                 920                 925             


Gln Glu Lys Asp Asp Leu Lys Gln Leu Gln Glu Ser Leu Gln Ile Glu 
    930                 935                 940                 


Arg Asp Gln Leu Lys Ser Asp Ile His Asp Thr Val Asn Met Asn Ile 
945                 950                 955                 960 


Asp Thr Gln Glu Gln Leu Arg Asn Ala Leu Glu Ser Leu Lys Gln His 
                965                 970                 975     


Gln Glu Thr Ile Asn Thr Leu Lys Ser Lys Ile Ser Glu Glu Val Ser 
            980                 985                 990         


Arg Asn Leu His Met Glu Glu Asn  Thr Gly Glu Thr Lys  Asp Glu Phe 
        995                 1000                 1005             


Gln Gln  Lys Met Val Gly Ile  Asp Lys Lys Gln Asp  Leu Glu Ala 
    1010                 1015                 1020             


Lys Asn  Thr Gln Thr Leu Thr  Ala Asp Val Lys Asp  Asn Glu Ile 
    1025                 1030                 1035             


Ile Glu  Gln Gln Arg Lys Ile  Phe Ser Leu Ile Gln  Glu Lys Asn 
    1040                 1045                 1050             


Glu Leu  Gln Gln Met Leu Glu  Ser Val Ile Ala Glu  Lys Glu Gln 
    1055                 1060                 1065             


Leu Lys  Thr Asp Leu Lys Glu  Asn Ile Glu Met Thr  Ile Glu Asn 
    1070                 1075                 1080             


Gln Glu  Glu Leu Arg Leu Leu  Gly Asp Glu Leu Lys  Lys Gln Gln 
    1085                 1090                 1095             


Glu Ile  Val Ala Gln Glu Lys  Asn His Ala Ile Lys  Lys Glu Gly 
    1100                 1105                 1110             


Glu Leu  Ser Arg Thr Cys Asp  Arg Leu Ala Glu Val  Glu Glu Lys 
    1115                 1120                 1125             


Leu Lys  Glu Lys Ser Gln Gln  Leu Gln Glu Lys Gln  Gln Gln Leu 
    1130                 1135                 1140             


Leu Asn  Val Gln Glu Glu Met  Ser Glu Met Gln Lys  Lys Ile Asn 
    1145                 1150                 1155             


Glu Ile  Glu Asn Leu Lys Asn  Glu Leu Lys Asn Lys  Glu Leu Thr 
    1160                 1165                 1170             


Leu Glu  His Met Glu Thr Glu  Arg Leu Glu Leu Ala  Gln Lys Leu 
    1175                 1180                 1185             


Asn Glu  Asn Tyr Glu Glu Val  Lys Ser Ile Thr Lys  Glu Arg Lys 
    1190                 1195                 1200             


Val Leu  Lys Glu Leu Gln Lys  Ser Phe Glu Thr Glu  Arg Asp His 
    1205                 1210                 1215             


Leu Arg  Gly Tyr Ile Arg Glu  Ile Glu Ala Thr Gly  Leu Gln Thr 
    1220                 1225                 1230             


Lys Glu  Glu Leu Lys Ile Ala  His Ile His Leu Lys  Glu His Gln 
    1235                 1240                 1245             


Glu Thr  Ile Asp Glu Leu Arg  Arg Ser Val Ser Glu  Lys Thr Ala 
    1250                 1255                 1260             


Gln Ile  Ile Asn Thr Gln Asp  Leu Glu Lys Ser His  Thr Lys Leu 
    1265                 1270                 1275             


Gln Glu  Glu Ile Pro Val Leu  His Glu Glu Gln Glu  Leu Leu Pro 
    1280                 1285                 1290             


Asn Val  Lys Glu Val Ser Glu  Thr Gln Glu Thr Met  Asn Glu Leu 
    1295                 1300                 1305             


Glu Leu  Leu Thr Glu Gln Ser  Thr Thr Lys Asp Ser  Thr Thr Leu 
    1310                 1315                 1320             


Ala Arg  Ile Glu Met Glu Arg  Leu Arg Leu Asn Glu  Lys Phe Gln 
    1325                 1330                 1335             


Glu Ser  Gln Glu Glu Ile Lys  Ser Leu Thr Lys Glu  Arg Asp Asn 
    1340                 1345                 1350             


Leu Lys  Thr Ile Lys Glu Ala  Leu Glu Val Lys His  Asp Gln Leu 
    1355                 1360                 1365             


Lys Glu  His Ile Arg Glu Thr  Leu Ala Lys Ile Gln  Glu Ser Gln 
    1370                 1375                 1380             


Ser Lys  Gln Glu Gln Ser Leu  Asn Met Lys Glu Lys  Asp Asn Glu 
    1385                 1390                 1395             


Thr Thr  Lys Ile Val Ser Glu  Met Glu Gln Phe Lys  Pro Lys Asp 
    1400                 1405                 1410             


Ser Ala  Leu Leu Arg Ile Glu  Ile Glu Met Leu Gly  Leu Ser Lys 
    1415                 1420                 1425             


Arg Leu  Gln Glu Ser His Asp  Glu Met Lys Ser Val  Ala Lys Glu 
    1430                 1435                 1440             


Lys Asp  Asp Leu Gln Arg Leu  Gln Glu Val Leu Gln  Ser Glu Ser 
    1445                 1450                 1455             


Asp Gln  Leu Lys Glu Asn Ile  Lys Glu Ile Val Ala  Lys His Leu 
    1460                 1465                 1470             


Glu Thr  Glu Glu Glu Leu Lys  Val Ala His Cys Cys  Leu Lys Glu 
    1475                 1480                 1485             


Gln Glu  Glu Thr Ile Asn Glu  Leu Arg Val Asn Leu  Ser Glu Lys 
    1490                 1495                 1500             


Glu Thr  Glu Ile Ser Thr Ile  Gln Lys Gln Leu Glu  Ala Ile Asn 
    1505                 1510                 1515             


Asp Lys  Leu Gln Asn Lys Ile  Gln Glu Ile Tyr Glu  Lys Glu Glu 
    1520                 1525                 1530             


Gln Phe  Asn Ile Lys Gln Ile  Ser Glu Val Gln Glu  Lys Val Asn 
    1535                 1540                 1545             


Glu Leu  Lys Gln Phe Lys Glu  His Arg Lys Ala Lys  Asp Ser Ala 
    1550                 1555                 1560             


Leu Gln  Ser Ile Glu Ser Lys  Met Leu Glu Leu Thr  Asn Arg Leu 
    1565                 1570                 1575             


Gln Glu  Ser Gln Glu Glu Ile  Gln Ile Met Ile Lys  Glu Lys Glu 
    1580                 1585                 1590             


Glu Met  Lys Arg Val Gln Glu  Ala Leu Gln Ile Glu  Arg Asp Gln 
    1595                 1600                 1605             


Leu Lys  Glu Asn Thr Lys Glu  Ile Val Ala Lys Met  Lys Glu Ser 
    1610                 1615                 1620             


Gln Glu  Lys Glu Tyr Gln Phe  Leu Lys Met Thr Ala  Val Asn Glu 
    1625                 1630                 1635             


Thr Gln  Glu Lys Met Cys Glu  Ile Glu His Leu Lys  Glu Gln Phe 
    1640                 1645                 1650             


Glu Thr  Gln Lys Leu Asn Leu  Glu Asn Ile Glu Thr  Glu Asn Ile 
    1655                 1660                 1665             


Arg Leu  Thr Gln Ile Leu His  Glu Asn Leu Glu Glu  Met Arg Ser 
    1670                 1675                 1680             


Val Thr  Lys Glu Arg Asp Asp  Leu Arg Ser Val Glu  Glu Thr Leu 
    1685                 1690                 1695             


Lys Val  Glu Arg Asp Gln Leu  Lys Glu Asn Leu Arg  Glu Thr Ile 
    1700                 1705                 1710             


Thr Arg  Asp Leu Glu Lys Gln  Glu Glu Leu Lys Ile  Val His Met 
    1715                 1720                 1725             


His Leu  Lys Glu His Gln Glu  Thr Ile Asp Lys Leu  Arg Gly Ile 
    1730                 1735                 1740             


Val Ser  Glu Lys Thr Asn Glu  Ile Ser Asn Met Gln  Lys Asp Leu 
    1745                 1750                 1755             


Glu His  Ser Asn Asp Ala Leu  Lys Ala Gln Asp Leu  Lys Ile Gln 
    1760                 1765                 1770             


Glu Glu  Leu Arg Ile Ala His  Met His Leu Lys Glu  Gln Gln Glu 
    1775                 1780                 1785             


Thr Ile  Asp Lys Leu Arg Gly  Ile Val Ser Glu Lys  Thr Asp Lys 
    1790                 1795                 1800             


Leu Ser  Asn Met Gln Lys Asp  Leu Glu Asn Ser Asn  Ala Lys Leu 
    1805                 1810                 1815             


Gln Glu  Lys Ile Gln Glu Leu  Lys Ala Asn Glu His  Gln Leu Ile 
    1820                 1825                 1830             


Thr Leu  Lys Lys Asp Val Asn  Glu Thr Gln Lys Lys  Val Ser Glu 
    1835                 1840                 1845             


Met Glu  Gln Leu Lys Lys Gln  Ile Lys Asp Gln Ser  Leu Thr Leu 
    1850                 1855                 1860             


Ser Lys  Leu Glu Ile Glu Asn  Leu Asn Leu Ala Gln  Lys Leu His 
    1865                 1870                 1875             


Glu Asn  Leu Glu Glu Met Lys  Ser Val Met Lys Glu  Arg Asp Asn 
    1880                 1885                 1890             


Leu Arg  Arg Val Glu Glu Thr  Leu Lys Leu Glu Arg  Asp Gln Leu 
    1895                 1900                 1905             


Lys Glu  Ser Leu Gln Glu Thr  Lys Ala Arg Asp Leu  Glu Ile Gln 
    1910                 1915                 1920             


Gln Glu  Leu Lys Thr Ala Arg  Met Leu Ser Lys Glu  His Lys Glu 
    1925                 1930                 1935             


Thr Val  Asp Lys Leu Arg Glu  Lys Ile Ser Glu Lys  Thr Ile Gln 
    1940                 1945                 1950             


Ile Ser  Asp Ile Gln Lys Asp  Leu Asp Lys Ser Lys  Asp Glu Leu 
    1955                 1960                 1965             


Gln Lys  Lys Ile Gln Glu Leu  Gln Lys Lys Glu Leu  Gln Leu Leu 
    1970                 1975                 1980             


Arg Val  Lys Glu Asp Val Asn  Met Ser His Lys Lys  Ile Asn Glu 
    1985                 1990                 1995             


Met Glu  Gln Leu Lys Lys Gln  Phe Glu Ala Gln Asn  Leu Ser Met 
    2000                 2005                 2010             


Gln Ser  Val Arg Met Asp Asn  Phe Gln Leu Thr Lys  Lys Leu His 
    2015                 2020                 2025             


Glu Ser  Leu Glu Glu Ile Arg  Ile Val Ala Lys Glu  Arg Asp Glu 
    2030                 2035                 2040             


Leu Arg  Arg Ile Lys Glu Ser  Leu Lys Met Glu Arg  Asp Gln Phe 
    2045                 2050                 2055             


Ile Ala  Thr Leu Arg Glu Met  Ile Ala Arg Asp Arg  Gln Asn His 
    2060                 2065                 2070             


Gln Val  Lys Pro Glu Lys Arg  Leu Leu Ser Asp Gly  Gln Gln His 
    2075                 2080                 2085             


Leu Thr  Glu Ser Leu Arg Glu  Lys Cys Ser Arg Ile  Lys Glu Leu 
    2090                 2095                 2100             


Leu Lys  Arg Tyr Ser Glu Met  Asp Asp His Tyr Glu  Cys Leu Asn 
    2105                 2110                 2115             


Arg Leu  Ser Leu Asp Leu Glu  Lys Glu Ile Glu Phe  Gln Lys Glu 
    2120                 2125                 2130             


Leu Ser  Met Arg Val Lys Ala  Asn Leu Ser Leu Pro  Tyr Leu Gln 
    2135                 2140                 2145             


Thr Lys  His Ile Glu Lys Leu  Phe Thr Ala Asn Gln  Arg Cys Ser 
    2150                 2155                 2160             


Met Glu  Phe His Arg Ile Met  Lys Lys Leu Lys Tyr  Val Leu Ser 
    2165                 2170                 2175             


Tyr Val  Thr Lys Ile Lys Glu  Glu Gln His Glu Ser  Ile Asn Lys 
    2180                 2185                 2190             


Phe Glu  Met Asp Phe Ile Asp  Glu Val Glu Lys Gln  Lys Glu Leu 
    2195                 2200                 2205             


Leu Ile  Lys Ile Gln His Leu  Gln Gln Asp Cys Asp  Val Pro Ser 
    2210                 2215                 2220             


Arg Glu  Leu Arg Asp Leu Lys  Leu Asn Gln Asn Met  Asp Leu His 
    2225                 2230                 2235             


Ile Glu  Glu Ile Leu Lys Asp  Phe Ser Glu Ser Glu  Phe Pro Ser 
    2240                 2245                 2250             


Ile Lys  Thr Glu Phe Gln Gln  Val Leu Ser Asn Arg  Lys Glu Met 
    2255                 2260                 2265             


Thr Gln  Phe Leu Glu Glu Trp  Leu Asn Thr Arg Phe  Asp Ile Glu 
    2270                 2275                 2280             


Lys Leu  Lys Asn Gly Ile Gln  Lys Glu Asn Asp Arg  Ile Cys Gln 
    2285                 2290                 2295             


Val Asn  Asn Phe Phe Asn Asn  Arg Ile Ile Ala Ile  Met Asn Glu 
    2300                 2305                 2310             


Ser Thr  Glu Phe Glu Glu Arg  Ser Ala Thr Ile Ser  Lys Glu Trp 
    2315                 2320                 2325             


Glu Gln  Asp Leu Lys Ser Leu  Lys Glu Lys Asn Glu  Lys Leu Phe 
    2330                 2335                 2340             


Lys Asn  Tyr Gln Thr Leu Lys  Thr Ser Leu Ala Ser  Gly Ala Gln 
    2345                 2350                 2355             


Val Asn  Pro Thr Thr Gln Asp  Asn Lys Asn Pro His  Val Thr Ser 
    2360                 2365                 2370             


Arg Ala  Thr Gln Leu Thr Thr  Glu Lys Ile Arg Glu  Leu Glu Asn 
    2375                 2380                 2385             


Ser Leu  His Glu Ala Lys Glu  Ser Ala Met His Lys  Glu Ser Lys 
    2390                 2395                 2400             


Ile Ile  Lys Met Gln Lys Glu  Leu Glu Val Thr Asn  Asp Ile Ile 
    2405                 2410                 2415             


Ala Lys  Leu Gln Ala Lys Val  His Glu Ser Asn Lys  Cys Leu Glu 
    2420                 2425                 2430             


Lys Thr  Lys Glu Thr Ile Gln  Val Leu Gln Asp Lys  Val Ala Leu 
    2435                 2440                 2445             


Gly Ala  Lys Pro Tyr Lys Glu  Glu Ile Glu Asp Leu  Lys Met Lys 
    2450                 2455                 2460             


Leu Val  Lys Ile Asp Leu Glu  Lys Met Lys Asn Ala  Lys Glu Phe 
    2465                 2470                 2475             


Glu Lys  Glu Ile Ser Ala Thr  Lys Ala Thr Val Glu  Tyr Gln Lys 
    2480                 2485                 2490             


Glu Val  Ile Arg Leu Leu Arg  Glu Asn Leu Arg Arg  Ser Gln Gln 
    2495                 2500                 2505             


Ala Gln  Asp Thr Ser Val Ile  Ser Glu His Thr Asp  Pro Gln Pro 
    2510                 2515                 2520             


Ser Asn  Lys Pro Leu Thr Cys  Gly Gly Gly Ser Gly  Ile Val Gln 
    2525                 2530                 2535             


Asn Thr  Lys Ala Leu Ile Leu  Lys Ser Glu His Ile  Arg Leu Glu 
    2540                 2545                 2550             


Lys Glu  Ile Ser Lys Leu Lys  Gln Gln Asn Glu Gln  Leu Ile Lys 
    2555                 2560                 2565             


Gln Lys  Asn Glu Leu Leu Ser  Asn Asn Gln His Leu  Ser Asn Glu 
    2570                 2575                 2580             


Val Lys  Thr Trp Lys Glu Arg  Thr Leu Lys Arg Glu  Ala His Lys 
    2585                 2590                 2595             


Gln Val  Thr Cys Glu Asn Ser  Pro Lys Ser Pro Lys  Val Thr Gly 
    2600                 2605                 2610             


Thr Ala  Ser Lys Lys Lys Gln  Ile Thr Pro Ser Gln  Cys Lys Glu 
    2615                 2620                 2625             


Arg Asn  Leu Gln Asp Pro Val  Pro Lys Glu Ser Pro  Lys Ser Cys 
    2630                 2635                 2640             


Phe Phe  Asp Ser Arg Ser Lys  Ser Leu Pro Ser Pro  His Pro Val 
    2645                 2650                 2655             


Arg Tyr  Phe Asp Asn Ser Ser  Leu Gly Leu Cys Pro  Glu Val Gln 
    2660                 2665                 2670             


Asn Ala  Gly Ala Glu Ser Val  Asp Ser Gln Pro Gly  Pro Trp His 
    2675                 2680                 2685             


Ala Ser  Ser Gly Lys Asp Val  Pro Glu Cys Lys Thr  Gln 
    2690                 2695                 2700     


<210>  2
<211>  8630
<212>  DNA
<213>  Homo sapiens

<400>  2
taaatttaaa ggcggggcgg cctgtgagcc ctgaagtgcc ggccgcggag ggtcctggcc       60

attttcctgg gaccagttca gcctgatagg atggcggagg aaggagccgt ggccgtctgc      120

gtgcgagtgc ggccgctgaa cagcagagaa gaatcacttg gagaaactgc ccaagtttac      180

tggaaaactg acaataatgt catttatcaa gttgatggaa gtaaatcctt caattttgat      240

cgtgtctttc atggtaatga aactaccaaa aatgtgtatg aagaaatagc agcaccaatc      300

atcgattctg ccatacaagg ctacaatggt actatatttg cctatggaca gactgcttca      360

ggaaaaacat ataccatgat gggttcagaa gatcatttgg gagttatacc cagggcaatt      420

catgacattt tccaaaaaat taagaagttt cctgataggg aatttctctt acgtgtatct      480

tacatggaaa tatacaatga aaccattaca gatttactct gtggcactca aaaaatgaaa      540

cctttaatta ttcgagaaga tgtcaatagg aatgtgtatg ttgctgatct cacagaagaa      600

gttgtatata catcagaaat ggctttgaaa tggattacaa agggagaaaa gagcaggcat      660

tatggagaaa caaaaatgaa tcaaagaagc agtcgttctc ataccatctt taggatgatt      720

ttggaaagca gagagaaggg tgaaccttct aattgtgaag gatctgttaa ggtatcccat      780

ttgaatttgg ttgatcttgc aggcagtgaa agagctgctc aaacaggcgc tgcaggtgtg      840

cggctcaagg aaggctgtaa tataaatcga agcttattta ttttgggaca agtgatcaag      900

aaacttagtg atggacaagt tggtggtttc ataaattatc gagatagcaa gttaacacga      960

attctccaga attccttggg aggaaatgca aagacacgta ttatctgcac aattactcca     1020

gtatcttttg atgaaacact tactgctctc cagtttgcca gtactgctaa atatatgaag     1080

aatactcctt atgttaatga ggtatcaact gatgaagctc tcctgaaaag gtatagaaaa     1140

gaaataatgg atcttaaaaa acaattagag gaggtttctt tagagacgcg ggctcaggca     1200

atggaaaaag accaattggc ccaacttttg gaagaaaaag atttgcttca gaaagtacag     1260

aatgagaaaa ttgaaaactt aacacggatg ctggtgacct cttcttccct cacgttgcaa     1320

caggaattaa aggctaaaag aaaacgaaga gttacttggt gccttggcaa aattaacaaa     1380

atgaagaact caaactatgc agatcaattt aatataccaa caaatataac aacaaaaaca     1440

cataagcttt ctataaattt attacgagaa attgatgaat ctgtctgttc agagtctgat     1500

gttttcagta acactcttga tacattaagt gagatagaat ggaatccagc aacaaagcta     1560

ctaaatcagg agaatataga aagtgagttg aactcacttc gtgctgacta tgataatctg     1620

gtattagact atgaacaact acgaacagaa aaagaagaaa tggaattgaa attaaaagaa     1680

aagaatgatt tggatgaatt tgaggctcta gaaagaaaaa ctaaaaaaga tcaagagatg     1740

caactaattc atgaaatttc gaacttaaag aatttagtta agcatgcaga agtatataat     1800

caagatcttg agaatgaact cagttcaaaa gtagagctgc ttagagaaaa ggaagaccag     1860

attaagaagc tacaggaata catagactct caaaagctag aaaatataaa aatggacttg     1920

tcatactcat tggaaagcat tgaagaccca aaacaaatga agcagactct gtttgatgct     1980

gaaactgtag cccttgatgc caagagagaa tcagcctttc ttagaagtga aaatctggag     2040

ctgaaggaga aaatgaaaga acttgcaact acatacaagc aaatggaaaa tgatattcag     2100

ttatatcaaa gccagttgga ggcaaaaaag aaaatgcaag ttgatctgga gaaagaatta     2160

caatctgctt ttaatgagat aacaaaactc acctccctta tagatggcaa agttccaaaa     2220

gatttgctct gtaatttgga attggaagga aagattactg atcttcagaa agaactaaat     2280

aaagaagttg aagaaaatga agctttgcgg gaagaagtca ttttgctttc agaattgaaa     2340

tctttacctt ctgaagtaga aaggctgagg aaagagatac aagacaaatc tgaagagctc     2400

catataataa catcagaaaa agataaattg ttttctgaag tagttcataa ggagagtaga     2460

gttcaaggtt tacttgaaga aattgggaaa acaaaagatg acctagcaac tacacagtcg     2520

aattataaaa gcactgatca agaattccaa aatttcaaaa cccttcatat ggactttgag     2580

caaaagtata agatggtcct tgaggagaat gagagaatga atcaggaaat agttaatctc     2640

tctaaagaag cccaaaaatt tgattcgagt ttgggtgctt tgaagaccga gctttcttac     2700

aagacccaag aacttcagga gaaaacacgt gaggttcaag aaagactaaa tgagatggaa     2760

cagctgaagg aacaattaga aaatagagat tctacgctgc aaactgtaga aagggagaaa     2820

acactgatta ctgagaaact gcagcaaact ttagaagaag taaaaacttt aactcaagaa     2880

aaagatgatc taaaacaact ccaagaaagc ttgcaaattg agagggacca actcaaaagt     2940

gatattcacg atactgttaa catgaatata gatactcaag aacaattacg aaatgctctt     3000

gagtctctga aacaacatca agaaacaatt aatacactaa aatcgaaaat ttctgaggaa     3060

gtttccagga atttgcatat ggaggaaaat acaggagaaa ctaaagatga atttcagcaa     3120

aagatggttg gcatagataa aaaacaggat ttggaagcta aaaataccca aacactaact     3180

gcagatgtta aggataatga gataattgag caacaaagga agatattttc tttaatacag     3240

gagaaaaatg aactccaaca aatgttagag agtgttatag cagaaaagga acaattgaag     3300

actgacctaa aggaaaatat tgaaatgacc attgaaaacc aggaagaatt aagacttctt     3360

ggggatgaac ttaaaaagca acaagagata gttgcacaag aaaagaacca tgccataaag     3420

aaagaaggag agctttctag gacctgtgac agactggcag aagttgaaga aaaactaaag     3480

gaaaagagcc agcaactcca agaaaaacag caacaacttc ttaatgtaca agaagagatg     3540

agtgagatgc agaaaaagat taatgaaata gagaatttaa agaatgaatt aaagaacaaa     3600

gaattgacat tggaacatat ggaaacagag aggcttgagt tggctcagaa acttaatgaa     3660

aattatgagg aagtgaaatc tataaccaaa gaaagaaaag ttctaaagga attacagaag     3720

tcatttgaaa cagagagaga ccaccttaga ggatatataa gagaaattga agctacaggc     3780

ctacaaacca aagaagaact aaaaattgct catattcacc taaaagaaca ccaagaaact     3840

attgatgaac taagaagaag cgtatctgag aagacagctc aaataataaa tactcaggac     3900

ttagaaaaat cccataccaa attacaagaa gagatcccag tgcttcatga ggaacaagag     3960

ttactgccta atgtgaaaga agtcagtgag actcaggaaa caatgaatga actggagtta     4020

ttaacagaac agtccacaac caaggactca acaacactgg caagaataga aatggaaagg     4080

ctcaggttga atgaaaaatt tcaagaaagt caggaagaga taaaatctct aaccaaggaa     4140

agagacaacc ttaaaacgat aaaagaagcc cttgaagtta aacatgacca gctgaaagaa     4200

catattagag aaactttggc taaaatccag gagtctcaaa gcaaacaaga acagtcctta     4260

aatatgaaag aaaaagacaa tgaaactacc aaaatcgtga gtgagatgga gcaattcaaa     4320

cccaaagatt cagcactact aaggatagaa atagaaatgc tcggattgtc caaaagactt     4380

caagaaagtc atgatgaaat gaaatctgta gctaaggaga aagatgacct acagaggctg     4440

caagaagttc ttcaatctga aagtgaccag ctcaaagaaa acataaaaga aattgtagct     4500

aaacacctgg aaactgaaga ggaacttaaa gttgctcatt gttgcctgaa agaacaagag     4560

gaaactatta atgagttaag agtgaatctt tcagagaagg aaactgaaat atcaaccatt     4620

caaaagcagt tagaagcaat caatgataaa ttacagaaca agatccaaga gatttatgag     4680

aaagaggaac aatttaatat aaaacaaatt agtgaggttc aggaaaaagt gaatgaactg     4740

aaacaattca aggagcatcg caaagccaag gattcagcac tacaaagtat agaaagtaag     4800

atgctcgagt tgaccaacag acttcaagaa agtcaagaag aaatacaaat tatgattaag     4860

gaaaaagagg aaatgaaaag agtacaggag gcccttcaga tagagagaga ccaactgaaa     4920

gaaaacacta aagaaattgt agctaaaatg aaagaatctc aagaaaaaga atatcagttt     4980

cttaagatga cagctgtcaa tgagactcag gagaaaatgt gtgaaataga acacttgaag     5040

gagcaatttg agacccagaa gttaaacctg gaaaacatag aaacggagaa tataaggttg     5100

actcagatac tacatgaaaa ccttgaagaa atgagatctg taacaaaaga aagagatgac     5160

cttaggagtg tggaggagac tctcaaagta gagagagacc agctcaagga aaaccttaga     5220

gaaactataa ctagagacct agaaaaacaa gaggagctaa aaattgttca catgcatctg     5280

aaggagcacc aagaaactat tgataaacta agagggattg tttcagagaa aacaaatgaa     5340

atatcaaata tgcaaaagga cttagaacac tcaaatgatg ccttaaaagc acaggatctg     5400

aaaatacaag aggaactaag aattgctcac atgcatctga aagagcagca ggaaactatt     5460

gacaaactca gaggaattgt ttctgagaag acagataaac tatcaaatat gcaaaaagat     5520

ttagaaaatt caaatgctaa attacaagaa aagattcaag aacttaaggc aaatgaacat     5580

caacttatta cgttaaaaaa agatgtcaat gagacacaga aaaaagtgtc tgaaatggag     5640

caactaaaga aacaaataaa agaccaaagc ttaactctga gtaaattaga aatagagaat     5700

ttaaatttgg ctcagaaact tcatgaaaac cttgaagaaa tgaaatctgt aatgaaagaa     5760

agagataatc taagaagagt agaggagaca ctcaaactgg agagagacca actcaaggaa     5820

agcctgcaag aaaccaaagc tagagatctg gaaatacaac aggaactaaa aactgctcgt     5880

atgctatcaa aagaacacaa agaaactgtt gataaactta gagaaaaaat ttcagaaaag     5940

acaattcaaa tttcagacat tcaaaaggat ttagataaat caaaagatga attacagaaa     6000

aagatccaag aacttcagaa aaaagaactt caactgctta gagtgaaaga agatgtcaat     6060

atgagtcata aaaaaattaa tgaaatggaa cagttgaaga agcaatttga ggcccaaaac     6120

ttatctatgc aaagtgtgag aatggataac ttccagttga ctaagaaact tcatgaaagc     6180

cttgaagaaa taagaattgt agctaaagaa agagatgagc taaggaggat aaaagaatct     6240

ctcaaaatgg aaagggacca attcatagca accttaaggg aaatgatagc tagagaccga     6300

cagaaccacc aagtaaaacc tgaaaaaagg ttactaagtg atggacaaca gcaccttacg     6360

gaaagcctga gagaaaagtg ctctagaata aaagagcttt tgaagagata ctcagagatg     6420

gatgatcatt atgagtgctt gaatagattg tctcttgact tggagaagga aattgaattc     6480

caaaaagagc tttcaatgag agttaaagca aacctctcac ttccctattt acaaaccaaa     6540

cacattgaaa aactttttac tgcaaaccag agatgctcca tggaattcca cagaatcatg     6600

aagaaactga agtatgtgtt aagctatgtt acaaaaataa aagaagaaca acatgaatcc     6660

atcaataaat ttgaaatgga ttttattgat gaagtggaaa agcaaaagga attgctaatt     6720

aaaatacagc accttcaaca agattgtgat gtaccatcca gagaattaag ggatctcaaa     6780

ttgaaccaga atatggatct acatattgag gaaattctca aagatttctc agaaagtgag     6840

ttccctagca taaagactga atttcaacaa gtactaagta ataggaaaga aatgacacag     6900

tttttggaag agtggttaaa tactcgtttt gatatagaaa agcttaaaaa tggcatccag     6960

aaagaaaatg ataggatttg tcaagtgaat aacttcttta ataacagaat aattgccata     7020

atgaatgaat caacagagtt tgaggaaaga agtgctacca tatccaaaga gtgggaacag     7080

gacctgaaat cactgaaaga gaaaaatgaa aaactattta aaaactacca aacattgaag     7140

acttccttgg catctggtgc ccaggttaat cctaccacac aagacaataa gaatcctcat     7200

gttacatcaa gagctacaca gttaaccaca gagaaaattc gagagctgga aaattcactg     7260

catgaagcta aagaaagtgc tatgcataag gaaagcaaga ttataaagat gcagaaagaa     7320

cttgaggtga ctaatgacat aatagcaaaa cttcaagcca aagttcatga atcaaataaa     7380

tgccttgaaa aaacaaaaga gacaattcaa gtacttcagg acaaagttgc tttaggagct     7440

aagccatata aagaagaaat tgaagatctc aaaatgaagc ttgtgaaaat agacctagag     7500

aaaatgaaaa atgccaaaga atttgaaaag gaaatcagtg ctacaaaagc cactgtagaa     7560

tatcaaaagg aagttataag gctattgaga gaaaatctca gaagaagtca acaggcccaa     7620

gatacctcag tgatatcaga acatactgat cctcagcctt caaataaacc cttaacttgt     7680

ggaggtggca gcggcattgt acaaaacaca aaagctctta ttttgaaaag tgaacatata     7740

aggctagaaa aagaaatttc taagttaaag cagcaaaatg aacagctaat aaaacaaaag     7800

aatgaattgt taagcaataa tcagcatctt tccaatgagg tcaaaacttg gaaggaaaga     7860

acccttaaaa gagaggctca caaacaagta acttgtgaga attctccaaa gtctcctaaa     7920

gtgactggaa cagcttctaa aaagaaacaa attacaccct ctcaatgcaa ggaacggaat     7980

ttacaagatc ctgtgccaaa ggaatcacca aaatcttgtt tttttgatag ccgatcaaag     8040

tctttaccat cacctcatcc agttcgctat tttgataact caagtttagg cctttgtcca     8100

gaggtgcaaa atgcaggagc agagagtgtg gattctcagc caggtccttg gcacgcctcc     8160

tcaggcaagg atgtgcctga gtgcaaaact cagtagactc ctctttgtca cttctctgga     8220

gatccagcat tccttatttg gaaatgactt tgtttatgtg tctatccctg gtaatgatgt     8280

tgtagtgcag cttaatttca attcagtctt tactttgcca ctagagttga aagataaggg     8340

aacaggaaat gaatgcattg tggtaattta gaatggtgat agcaatacct tcttcttgca     8400

tatggtaata cttttaaaag ttgaattgtt ttatttattt gtatattttg taaagaataa     8460

agttattgaa agaaatgtaa agttatctac atgacttagc atattccaaa gcataataca     8520

tacattaata taaaacatca ttttattaac aaaattgtaa atgtttttaa taccttacac     8580

attcaataaa tgtttagtag ttctgaatca ccaaaaaaaa aaaaaaaaaa                8630


<210>  3
<211>  504
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Glu Ala Thr Gly Thr Trp Ala Leu Leu Leu Ala Leu Ala Leu Leu 
1               5                   10                  15      


Leu Leu Leu Thr Leu Ala Leu Ser Gly Thr Arg Ala Arg Gly His Leu 
            20                  25                  30          


Pro Pro Gly Pro Thr Pro Leu Pro Leu Leu Gly Asn Leu Leu Gln Leu 
        35                  40                  45              


Arg Pro Gly Ala Leu Tyr Ser Gly Leu Met Arg Leu Ser Lys Lys Tyr 
    50                  55                  60                  


Gly Pro Val Phe Thr Ile Tyr Leu Gly Pro Trp Arg Pro Val Val Val 
65                  70                  75                  80  


Leu Val Gly Gln Glu Ala Val Arg Glu Ala Leu Gly Gly Gln Ala Glu 
                85                  90                  95      


Glu Phe Ser Gly Arg Gly Thr Val Ala Met Leu Glu Gly Thr Phe Asp 
            100                 105                 110         


Gly His Gly Val Phe Phe Ser Asn Gly Glu Arg Trp Arg Gln Leu Arg 
        115                 120                 125             


Lys Phe Thr Met Leu Ala Leu Arg Asp Leu Gly Met Gly Lys Arg Glu 
    130                 135                 140                 


Gly Glu Glu Leu Ile Gln Ala Glu Ala Arg Cys Leu Val Glu Thr Phe 
145                 150                 155                 160 


Gln Gly Thr Glu Gly Arg Pro Phe Asp Pro Ser Leu Leu Leu Ala Gln 
                165                 170                 175     


Ala Thr Ser Asn Val Val Cys Ser Leu Leu Phe Gly Leu Arg Phe Ser 
            180                 185                 190         


Tyr Glu Asp Lys Glu Phe Gln Ala Val Val Arg Ala Ala Gly Gly Thr 
        195                 200                 205             


Leu Leu Gly Val Ser Ser Gln Gly Gly Gln Thr Tyr Glu Met Phe Ser 
    210                 215                 220                 


Trp Phe Leu Arg Pro Leu Pro Gly Pro His Lys Gln Leu Leu His His 
225                 230                 235                 240 


Val Ser Thr Leu Ala Ala Phe Thr Val Arg Gln Val Gln Gln His Gln 
                245                 250                 255     


Gly Asn Leu Asp Ala Ser Gly Pro Ala Arg Asp Leu Val Asp Ala Phe 
            260                 265                 270         


Leu Leu Lys Met Ala Gln Glu Glu Gln Asn Pro Gly Thr Glu Phe Thr 
        275                 280                 285             


Asn Lys Asn Met Leu Met Thr Val Ile Tyr Leu Leu Phe Ala Gly Thr 
    290                 295                 300                 


Met Thr Val Ser Thr Thr Val Gly Tyr Thr Leu Leu Leu Leu Met Lys 
305                 310                 315                 320 


Tyr Pro His Val Gln Lys Trp Val Arg Glu Glu Leu Asn Arg Glu Leu 
                325                 330                 335     


Gly Ala Gly Gln Ala Pro Ser Leu Gly Asp Arg Thr Arg Leu Pro Tyr 
            340                 345                 350         


Thr Asp Ala Val Leu His Glu Ala Gln Arg Leu Leu Ala Leu Val Pro 
        355                 360                 365             


Met Gly Ile Pro Arg Thr Leu Met Arg Thr Thr Arg Phe Arg Gly Tyr 
    370                 375                 380                 


Thr Leu Pro Gln Gly Thr Glu Val Phe Pro Leu Leu Gly Ser Ile Leu 
385                 390                 395                 400 


His Asp Pro Asn Ile Phe Lys His Pro Glu Glu Phe Asn Pro Asp Arg 
                405                 410                 415     


Phe Leu Asp Ala Asp Gly Arg Phe Arg Lys His Glu Ala Phe Leu Pro 
            420                 425                 430         


Phe Ser Leu Gly Lys Arg Val Cys Leu Gly Glu Gly Leu Ala Lys Ala 
        435                 440                 445             


Glu Leu Phe Leu Phe Phe Thr Thr Ile Leu Gln Ala Phe Ser Leu Glu 
    450                 455                 460                 


Ser Pro Cys Pro Pro Asp Thr Leu Ser Leu Lys Pro Thr Val Ser Gly 
465                 470                 475                 480 


Leu Phe Asn Ile Pro Pro Ala Phe Gln Leu Gln Val Arg Pro Thr Asp 
                485                 490                 495     


Leu His Ser Thr Thr Gln Thr Arg 
            500                 


<210>  4
<211>  2660
<212>  DNA
<213>  Homo sapiens

<400>  4
cctaactagc ccagccgcgc ggagcgcctg ggagaggaga aggagccgac ctgccgagat       60

ggaggcgacc ggcacctggg cgctgctgct ggcgctggcg ctgctcctgc tgctgacgct      120

ggcgctgtcc gggaccaggg cccgaggcca cctgcccccc gggcccacgc cgctaccact      180

gctgggaaac ctcctgcagc tacggcccgg ggcgctgtat tcagggctca tgcggctgag      240

taagaagtac ggaccggtgt tcaccatcta cctgggaccc tggcggcctg tggtggtcct      300

ggttgggcag gaggctgtgc gggaggccct gggaggtcag gctgaggagt tcagcggccg      360

gggaaccgta gcgatgctgg aagggacttt tgatggccat ggggttttct tctccaacgg      420

ggagcggtgg aggcagctga ggaagtttac catgcttgct ctgcgggacc tgggcatggg      480

gaagcgagaa ggcgaggagc tgatccaggc ggaggcccgg tgtctggtgg agacattcca      540

ggggacagaa ggacgcccat tcgatccctc cctgctgctg gcccaggcca cctccaacgt      600

agtctgctcc ctcctctttg gcctccgctt ctcctatgag gataaggagt tccaggccgt      660

ggtccgggca gctggtggta ccctgctggg agtcagctcc caggggggtc agacctacga      720

gatgttctcc tggttcctgc ggcccctgcc aggcccccac aagcagctcc tccaccacgt      780

cagcaccttg gctgccttca cagtccggca ggtgcagcag caccagggga acctggatgc      840

ttcgggcccc gcacgtgacc ttgtcgatgc cttcctgctg aagatggcac aggaggaaca      900

aaacccaggc acagaattca ccaacaagaa catgctgatg acagtcattt atttgctgtt      960

tgctgggacg atgacggtca gcaccacggt cggctatacc ctcctgctcc tgatgaaata     1020

ccctcatgtc caaaagtggg tacgtgagga gctgaatcgg gagctggggg ctggccaggc     1080

accaagccta ggggaccgta cccgcctccc ttacaccgac gcggttctgc atgaggcgca     1140

gcggctgctg gcgctggtgc ccatgggaat accccgcacc ctcatgcgga ccacccgctt     1200

ccgagggtac accctgcccc agggcacgga ggtcttcccc ctccttggct ccatcctgca     1260

tgaccccaac atcttcaagc acccagaaga gttcaaccca gaccgtttcc tggatgcaga     1320

tggacggttc aggaagcatg aggcgttcct gcccttctcc ttagggaagc gtgtctgcct     1380

tggagagggc ctggcaaaag cggagctctt cctcttcttc accaccatcc tacaagcctt     1440

ctccctggag agcccgtgcc cgccggacac cctgagcctc aagcccaccg tcagtggcct     1500

tttcaacatt cccccagcct tccagctgca agtccgtccc actgaccttc actccaccac     1560

gcagaccaga tgaaggaagg caacttggaa gtggtgggtg cccaggacgg tgcctccagc     1620

ctcaacagtg ggcatggaca gggttaatgt ctccagagtg tacactgcag gcagccacat     1680

ttacacgcct gcagttgttt tccggagtct gtcccacggc ccacacgctc acttgactca     1740

tgctgctaag atgcacaacc gcacacccat acacaactac aagggccaca aagcaactgc     1800

tgggttagct ttccacagac ataaatatag tccatctgca atcacaagca catagccagg     1860

taacccacca actcccctgg atctgcagcc cacacgtggg agtctggctg tcaccttcac     1920

aagccacaga aacggccaca catgttcaca gctcacacgc cctctccatt catcgaactt     1980

ctcagtgtcc ctgtccctgg tgcctggcac agggaacagc atgccccctc cggggtcatg     2040

ccacccagag actgtcgctg tctatggccc caactcatgc tccctctctt ggctacacca     2100

ctctcccagc ctgtgaccac cgatgtccac acacccccaa ccacttgtcc acacagctac     2160

ccacgtacga catcgtcctg gctccccaga gtatcttccc actgagacac gccgccccca     2220

cagaggcaca gtccccagcc acctctgcaa ctgcagccct cagtcacccc tttttaagca     2280

ccctgattct accaaatgca aacacatctg ggtctgcgat tatgcacaga gactttggac     2340

atacgaggac cctcagaccg gaggaacacc tgcccaaccc caacacgtgc ttatgtaacc     2400

acgtggaaag cggcccctgc tgcccctcca cacacacata cacactcact gatctacagc     2460

ccctgttcgg cgtcagagtc cccactagac ccagtggaag gggttagaga ccaagtaggg     2520

gccagtttcc aattcaccct gtcagggagt gagccggatc tgacgttcct tgtgacttaa     2580

gggtccggct tgggaattaa agtttgtttc tggcctttag cctaaaaaaa aaaaaaaaaa     2640

aaaaaaaaaa aaaaaaaaaa                                                 2660


<210>  5
<211>  257
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Ala Pro Ala Met Glu Ser Pro Thr Leu Leu Cys Val Ala Leu Leu 
1               5                   10                  15      


Phe Phe Ala Pro Asp Gly Val Leu Ala Val Pro Gln Lys Pro Lys Val 
            20                  25                  30          


Ser Leu Asn Pro Pro Trp Asn Arg Ile Phe Lys Gly Glu Asn Val Thr 
        35                  40                  45              


Leu Thr Cys Asn Gly Asn Asn Phe Phe Glu Val Ser Ser Thr Lys Trp 
    50                  55                  60                  


Phe His Asn Gly Ser Leu Ser Glu Glu Thr Asn Ser Ser Leu Asn Ile 
65                  70                  75                  80  


Val Asn Ala Lys Phe Glu Asp Ser Gly Glu Tyr Lys Cys Gln His Gln 
                85                  90                  95      


Gln Val Asn Glu Ser Glu Pro Val Tyr Leu Glu Val Phe Ser Asp Trp 
            100                 105                 110         


Leu Leu Leu Gln Ala Ser Ala Glu Val Val Met Glu Gly Gln Pro Leu 
        115                 120                 125             


Phe Leu Arg Cys His Gly Trp Arg Asn Trp Asp Val Tyr Lys Val Ile 
    130                 135                 140                 


Tyr Tyr Lys Asp Gly Glu Ala Leu Lys Tyr Trp Tyr Glu Asn His Asn 
145                 150                 155                 160 


Ile Ser Ile Thr Asn Ala Thr Val Glu Asp Ser Gly Thr Tyr Tyr Cys 
                165                 170                 175     


Thr Gly Lys Val Trp Gln Leu Asp Tyr Glu Ser Glu Pro Leu Asn Ile 
            180                 185                 190         


Thr Val Ile Lys Ala Pro Arg Glu Lys Tyr Trp Leu Gln Phe Phe Ile 
        195                 200                 205             


Pro Leu Leu Val Val Ile Leu Phe Ala Val Asp Thr Gly Leu Phe Ile 
    210                 215                 220                 


Ser Thr Gln Gln Gln Val Thr Phe Leu Leu Lys Ile Lys Arg Thr Arg 
225                 230                 235                 240 


Lys Gly Phe Arg Leu Leu Asn Pro His Pro Lys Pro Asn Pro Lys Asn 
                245                 250                 255     


Asn 
    


<210>  6
<211>  1198
<212>  DNA
<213>  Homo sapiens

<400>  6
tactaagagt ctccagcatc ctccacctgt ctaccaccga gcatgggcct atatttgaag       60

ccttagatct ctccagcaca gtaagcacca ggagtccatg aagaagatgg ctcctgccat      120

ggaatcccct actctactgt gtgtagcctt actgttcttc gctccagatg gcgtgttagc      180

agtccctcag aaacctaagg tctccttgaa ccctccatgg aatagaatat ttaaaggaga      240

gaatgtgact cttacatgta atgggaacaa tttctttgaa gtcagttcca ccaaatggtt      300

ccacaatggc agcctttcag aagagacaaa ttcaagtttg aatattgtga atgccaaatt      360

tgaagacagt ggagaataca aatgtcagca ccaacaagtt aatgagagtg aacctgtgta      420

cctggaagtc ttcagtgact ggctgctcct tcaggcctct gctgaggtgg tgatggaggg      480

ccagcccctc ttcctcaggt gccatggttg gaggaactgg gatgtgtaca aggtgatcta      540

ttataaggat ggtgaagctc tcaagtactg gtatgagaac cacaacatct ccattacaaa      600

tgccacagtt gaagacagtg gaacctacta ctgtacgggc aaagtgtggc agctggacta      660

tgagtctgag cccctcaaca ttactgtaat aaaagctccg cgtgagaagt actggctaca      720

attttttatc ccattgttgg tggtgattct gtttgctgtg gacacaggat tatttatctc      780

aactcagcag caggtcacat ttctcttgaa gattaagaga accaggaaag gcttcagact      840

tctgaaccca catcctaagc caaaccccaa aaacaactga tataattact caagaaatat      900

ttgcaacatt agtttttttc cagcatcagc aattgctact caattgtcaa acacagcttg      960

caatatacat agaaacgtct gtgctcaagg atttatagaa atgcttcatt aaactgagtg     1020

aaactggtta agtggcatgt aatagtaagt gctcaattaa cattggttga ataaatgaga     1080

gaatgaatag attcatttat tagcatttgt aaaagagatg ttcaatttca ataaaataaa     1140

tataaaacca tgtaacagaa tgcttctgag taaaaaaaaa aaaaaaaaaa aaaaaaaa       1198


<210>  7
<211>  177
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Glu Ile Cys Arg Gly Leu Arg Ser His Leu Ile Thr Leu Leu Leu 
1               5                   10                  15      


Phe Leu Phe His Ser Glu Thr Ile Cys Arg Pro Ser Gly Arg Lys Ser 
            20                  25                  30          


Ser Lys Met Gln Ala Phe Arg Ile Trp Asp Val Asn Gln Lys Thr Phe 
        35                  40                  45              


Tyr Leu Arg Asn Asn Gln Leu Val Ala Gly Tyr Leu Gln Gly Pro Asn 
    50                  55                  60                  


Val Asn Leu Glu Glu Lys Ile Asp Val Val Pro Ile Glu Pro His Ala 
65                  70                  75                  80  


Leu Phe Leu Gly Ile His Gly Gly Lys Met Cys Leu Ser Cys Val Lys 
                85                  90                  95      


Ser Gly Asp Glu Thr Arg Leu Gln Leu Glu Ala Val Asn Ile Thr Asp 
            100                 105                 110         


Leu Ser Glu Asn Arg Lys Gln Asp Lys Arg Phe Ala Phe Ile Arg Ser 
        115                 120                 125             


Asp Ser Gly Pro Thr Thr Ser Phe Glu Ser Ala Ala Cys Pro Gly Trp 
    130                 135                 140                 


Phe Leu Cys Thr Ala Met Glu Ala Asp Gln Pro Val Ser Leu Thr Asn 
145                 150                 155                 160 


Met Pro Asp Glu Gly Val Met Val Thr Lys Phe Tyr Phe Gln Glu Asp 
                165                 170                 175     


Glu 
    


<210>  8
<211>  1794
<212>  DNA
<213>  Homo sapiens

<400>  8
atttctttat aaaccacaac tctgggcccg caatggcagt ccactgcctt gctgcagtca       60

cagaatggaa atctgcagag gcctccgcag tcacctaatc actctcctcc tcttcctgtt      120

ccattcagag acgatctgcc gaccctctgg gagaaaatcc agcaagatgc aagccttcag      180

aatctgggat gttaaccaga agaccttcta tctgaggaac aaccaactag ttgctggata      240

cttgcaagga ccaaatgtca atttagaaga aaagatagat gtggtaccca ttgagcctca      300

tgctctgttc ttgggaatcc atggagggaa gatgtgcctg tcctgtgtca agtctggtga      360

tgagaccaga ctccagctgg aggcagttaa catcactgac ctgagcgaga acagaaagca      420

ggacaagcgc ttcgccttca tccgctcaga cagtggcccc accaccagtt ttgagtctgc      480

cgcctgcccc ggttggttcc tctgcacagc gatggaagct gaccagcccg tcagcctcac      540

caatatgcct gacgaaggcg tcatggtcac caaattctac ttccaggagg acgagtagta      600

ctgcccaggc ctgcctgttc ccattcttgc atggcaagga ctgcagggac tgccagtccc      660

cctgccccag ggctcccggc tatgggggca ctgaggacca gccattgagg ggtggaccct      720

cagaaggcgt cacaacaacc tggtcacagg actctgcctc ctcttcaact gaccagcctc      780

catgctgcct ccagaatggt ctttctaatg tgtgaatcag agcacagcag cccctgcaca      840

aagcccttcc atgtcgcctc tgcattcagg atcaaacccc gaccacctgc ccaacctgct      900

ctcctcttgc cactgcctct tcctccctca ttccaccttc ccatgccctg gatccatcag      960

gccacttgat gacccccaac caagtggctc ccacaccctg ttttacaaaa aagaaaagac     1020

cagtccatga gggaggtttt taagggtttg tggaaaatga aaattaggat ttcatgattt     1080

ttttttttca gtccccgtga aggagagccc ttcatttgga gattatgttc tttcggggag     1140

aggctgagga cttaaaatat tcctgcattt gtgaaatgat ggtgaaagta agtggtagct     1200

tttcccttct ttttcttctt tttttgtgat gtcccaactt gtaaaaatta aaagttatgg     1260

tactatgtta gccccataat tttttttttc cttttaaaac acttccataa tctggactcc     1320

tctgtccagg cactgctgcc cagcctccaa gctccatctc cactccagat tttttacagc     1380

tgcctgcagt actttacctc ctatcagaag tttctcagct cccaaggctc tgagcaaatg     1440

tggctcctgg gggttctttc ttcctctgct gaaggaataa attgctcctt gacattgtag     1500

agcttctggc acttggagac ttgtatgaaa gatggctgtg cctctgcctg tctcccccac     1560

cgggctggga gctctgcaga gcaggaaaca tgactcgtat atgtctcagg tccctgcagg     1620

gccaagcacc tagcctcgct cttggcaggt actcagcgaa tgaatgctgt atatgttggg     1680

tgcaaagttc cctacttcct gtgacttcag ctctgtttta caataaaatc ttgaaaatgc     1740

ctaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaa           1794


<210>  9
<211>  350
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Ala Ala Thr Ser Leu Met Ser Ala Leu Ala Ala Arg Leu Leu Gln 
1               5                   10                  15      


Pro Ala His Ser Cys Ser Leu Arg Leu Arg Pro Phe His Leu Ala Ala 
            20                  25                  30          


Val Arg Asn Glu Ala Val Val Ile Ser Gly Arg Lys Leu Ala Gln Gln 
        35                  40                  45              


Ile Lys Gln Glu Val Arg Gln Glu Val Glu Glu Trp Val Ala Ser Gly 
    50                  55                  60                  


Asn Lys Arg Pro His Leu Ser Val Ile Leu Val Gly Glu Asn Pro Ala 
65                  70                  75                  80  


Ser His Ser Tyr Val Leu Asn Lys Thr Arg Ala Ala Ala Val Val Gly 
                85                  90                  95      


Ile Asn Ser Glu Thr Ile Met Lys Pro Ala Ser Ile Ser Glu Glu Glu 
            100                 105                 110         


Leu Leu Asn Leu Ile Asn Lys Leu Asn Asn Asp Asp Asn Val Asp Gly 
        115                 120                 125             


Leu Leu Val Gln Leu Pro Leu Pro Glu His Ile Asp Glu Arg Arg Ile 
    130                 135                 140                 


Cys Asn Ala Val Ser Pro Asp Lys Asp Val Asp Gly Phe His Val Ile 
145                 150                 155                 160 


Asn Val Gly Arg Met Cys Leu Asp Gln Tyr Ser Met Leu Pro Ala Thr 
                165                 170                 175     


Pro Trp Gly Val Trp Glu Ile Ile Lys Arg Thr Gly Ile Pro Thr Leu 
            180                 185                 190         


Gly Lys Asn Val Val Val Ala Gly Arg Ser Lys Asn Val Gly Met Pro 
        195                 200                 205             


Ile Ala Met Leu Leu His Thr Asp Gly Ala His Glu Arg Pro Gly Gly 
    210                 215                 220                 


Asp Ala Thr Val Thr Ile Ser His Arg Tyr Thr Pro Lys Glu Gln Leu 
225                 230                 235                 240 


Lys Lys His Thr Ile Leu Ala Asp Ile Val Ile Ser Ala Ala Gly Ile 
                245                 250                 255     


Pro Asn Leu Ile Thr Ala Asp Met Ile Lys Glu Gly Ala Ala Val Ile 
            260                 265                 270         


Asp Val Gly Ile Asn Arg Val His Asp Pro Val Thr Ala Lys Pro Lys 
        275                 280                 285             


Leu Val Gly Asp Val Asp Phe Glu Gly Val Arg Gln Lys Ala Gly Tyr 
    290                 295                 300                 


Ile Thr Pro Val Pro Gly Gly Val Gly Pro Met Thr Val Ala Met Leu 
305                 310                 315                 320 


Met Lys Asn Thr Ile Ile Ala Ala Lys Lys Val Leu Arg Leu Glu Glu 
                325                 330                 335     


Arg Glu Val Leu Lys Ser Lys Glu Leu Gly Val Ala Thr Asn 
            340                 345                 350 


<210>  10
<211>  2208
<212>  DNA
<213>  Homo sapiens

<400>  10
ggggcctgcc acgaggccgc agtataaccg cgtggcccgc gcgcgcgctt ccctcccggc       60

gcagtcaccg gcgcggtcta tggctgcgac ttctctaatg tctgctttgg ctgcccggct      120

gctgcagccc gcgcacagct gctcccttcg ccttcgccct ttccacctcg cggcagttcg      180

aaatgaagct gttgtcattt ctggaaggaa actggcccag cagatcaagc aggaagtgcg      240

gcaggaggta gaagagtggg tggcctcagg caacaaacgg ccacacctga gtgtgatcct      300

ggttggcgag aatcctgcaa gtcactccta tgtcctcaac aaaaccaggg cagctgcagt      360

tgtgggaatc aacagtgaga caattatgaa accagcttca atttcagagg aagaattgtt      420

gaatttaatc aataaactga ataatgatga taatgtagat ggcctccttg ttcagttgcc      480

tcttccagag catattgatg agagaaggat ctgcaatgct gtttctccag acaaggatgt      540

tgatggcttt catgtaatta atgtaggacg aatgtgtttg gatcagtatt ccatgttacc      600

ggctactcca tggggtgtgt gggaaataat caagcgaact ggcattccaa ccctagggaa      660

gaatgtggtt gtggctggaa ggtcaaaaaa cgttggaatg cccattgcaa tgttactgca      720

cacagatggg gcgcatgaac gtcccggagg tgatgccact gttacaatat ctcatcgata      780

tactcccaaa gagcagttga agaaacatac aattcttgca gatattgtaa tatctgctgc      840

aggtattcca aatctgatca cagcagatat gatcaaggaa ggagcagcag tcattgatgt      900

gggaataaat agagttcacg atcctgtaac tgccaaaccc aagttggttg gagatgtgga      960

ttttgaagga gtcagacaaa aagctgggta tatcactcca gttcctggag gtgttggccc     1020

catgacagtg gcaatgctaa tgaagaatac cattattgct gcaaaaaagg tgctgaggct     1080

tgaagagcga gaagtgctga agtctaaaga gcttggggta gccactaatt aactactgtg     1140

tcttctgtgt cacaaacagc actccaggcc agctcaagaa gcaaagcagg ccaatagaaa     1200

tgcaatattt ttaatttatt ctactgaaat ggtttaaaat gatgccttgt atttattgaa     1260

agcttaaatg ggtgggtgtt tctgcacata cctctgcagt acctcaccag ggagcattcc     1320

agtatcatgc agggtcctgt gatctagcca ggagcagcca ttaacctagt gattaatatg     1380

ggagacatta ccatatggag gatggatgct tcactttgtc aagcacctca gttacacatt     1440

cgccttttct aggattgcat ttcccaagtg ctattgcaat aacagttgat actcatttta     1500

ggtaccaaac cttttgagtt caactgatca aaccaaagga aaagtgttgc tagagaaaat     1560

tagggaaaag gtgaaaaaga aaaaatggta gtaattgagc agaaaaaaat taatttatat     1620

atgtattgat tggcaaccag atttatctaa gtagaactga attggctagg aaaaaagaaa     1680

aactgcatgt taatcatttt cctaagctgt ccttttgagg cttagtcagt ttattgggaa     1740

aatgtttagg attattcctt gctattagta ctcattttat gtatgttacc cttcagtaag     1800

ttctccccat tttagttttc taggactgaa aggattcttt tctacattat acatgtgtgt     1860

tgtcatattt ggcttttgct atatacttta acttcattgt taaatttttg tattgtatag     1920

tttctttggt gtatcttaaa acctattttt gaaaaacaaa cttggcttga taatcatttg     1980

ggcagcttgg gtaagtacgc aacttacttt tccaccaaag aactgtcagc agctgcctgc     2040

ttttctgtga tgtatgtatc ctgttgactt ttccagaaat tttttaagag tttgagttac     2100

tattgaattt aatcagactt tctgattaaa gggttttctt tcttttttaa taaaacacat     2160

ctgtctggta tggtatgaat ttctgaaaaa aaaaaaaaaa aaaaaaaa                  2208


<210>  11
<211>  287
<212>  PRT
<213>  Homo sapiens

<400>  11

Glu Arg Cys Cys Arg Cys Cys Cys Arg Cys Pro Cys Cys Gly Gln Gly 
1               5                   10                  15      


Pro Arg Ser Gly Cys Lys Ile Pro Ala Gly Asp Ala Arg Val Arg Asp 
            20                  25                  30          


Gly Ala Gly Gly Ser Val His Leu Cys Ala Leu Phe Gly Leu Leu Pro 
        35                  40                  45              


Arg Val Trp Leu Glu Arg Phe Tyr Pro Cys Leu Trp Pro Leu Val Pro 
    50                  55                  60                  


Gly Lys Gly Gln Cys Arg Pro Gly Asp Ser Met Ala Thr Asn Asn Ser 
65                  70                  75                  80  


Thr Gln Lys Val Gln Lys Glu Thr Gln Gly Arg Phe His Leu Leu Gly 
                85                  90                  95      


Asp Pro Ser Arg Asn Asn Cys Ser Leu Ser Ile Arg Asp Ala Arg Arg 
            100                 105                 110         


Arg Asp Asn Gly Ser Tyr Phe Phe Trp Val Ala Arg Arg Arg Thr Lys 
        115                 120                 125             


Phe Ser Tyr Lys Tyr Ser Pro Leu Ser Val Tyr Val Thr Ala Leu Thr 
    130                 135                 140                 


His Arg Pro Asp Ile Leu Ile Pro Glu Phe Leu Lys Ser Gly His Pro 
145                 150                 155                 160 


Ser Asn Leu Thr Cys Ser Val Pro Trp Val Cys Glu Gln Gly Thr Pro 
                165                 170                 175     


Pro Ile Phe Ser Trp Met Ser Ala Ala Pro Thr Ser Leu Gly Pro Arg 
            180                 185                 190         


Thr Leu His Ser Ser Glu Leu Thr Ile Ile Pro Arg Pro Gln Asp His 
        195                 200                 205             


Gly Thr Asn Leu Ile Cys Gln Val Thr Phe Pro Gly Ala Gly Val Thr 
    210                 215                 220                 


Thr Glu Arg Thr Ile Gln Leu Ser Val Ser Trp Lys Ser Gly Thr Val 
225                 230                 235                 240 


Glu Glu Val Val Val Leu Ala Val Gly Val Val Ala Val Lys Ile Leu 
                245                 250                 255     


Leu Leu Cys Leu Cys Leu Ile Ile Leu Ser Phe His Lys Lys Lys Ala 
            260                 265                 270         


Val Arg Ala Val Glu Val Glu Glu Asn Val Tyr Ala Val Met Gly 
        275                 280                 285         


<210>  12
<211>  2251
<212>  DNA
<213>  Homo sapiens

<400>  12
ccaagatctc atgctcctcc ccacagccct cttctctgct cacacaggaa gcccaggaag       60

cctctgcctc agagatgctg ccgctgctgc tgccgctgcc cctgctgtgg gcagggccct      120

cgctcaggat gcaagattcc ggctggagat gccagagtcc gtgacggtgc aggagggtct      180

gtgcatcttt gtgcactgtt cggtcttcta cctcgagtat ggctggaaag attctacccc      240

tgcttatggc cactggttcc gggaaggggt cagtgtagac caggagactc cagtggccac      300

aaacaactca actcaaaaag tgcagaagga gacccagggc cgattccacc tcctcggtga      360

tccctcaagg aacaactgct ccctgagcat cagagacgcc aggaggaggg acaacggttc      420

atacttcttt tgggtggcga gaggaagaac aaaatttagt tacaaatatt ccccgctctc      480

tgtgtatgtg acagccctga cccacaggcc cgacatcctc atcccggagt tcctaaagtc      540

tggccatccc agcaacctga cctgctctgt gccctgggtc tgtgagcagg gaacaccccc      600

catcttctcc tggatgtcag ctgcccccac ctccctgggc cccaggaccc tccactcctc      660

agtgctcacg atcatcccac ggcctcagga ccacggcacc aacctcatct gtcaggtgac      720

gttccccgga gctggtgtga ccacggagag aaccatccag ctcagtgtct cctggaaatc      780

aggaaccgtg gaagaggtgg ttgttttggc cgtgggggta gtggctgtga agatcctgct      840

tctctgcctt tgcctcatca tcctcaggta agcactgcct gaagaccaag gacaggcatg      900

gggagggcag aggacatgat gctgaatccc agaatctcaa tcctgggggt atgcagacag      960

tttacgtggt cctggggcca ggctggaggc tgaattggtg gtgagaatta cacatgggcc     1020

atttgtggtc agtttgtgtc tgtcccaact gagggccaaa tgccaggatg gggagcttcc     1080

tgttgtcatc aaggaagtct agacctgctc ttcctccctg tgatccctcc agcctctagc     1140

agggcacagg aagttgagtt ggctgccctt tgctcccttc atgtggccac acttacaggt     1200

ccttgtctct tcactcaatg tcagtttcca caagaagaag gcggtgaggg cagtggaggt     1260

tgaggagaat gtatatgctg tcatgggtta atctctcagg tgagtgatgt gggcctctca     1320

ctcttcaaca tcctgctgga taactcctcc acaatggcct ccaggattgc tctgcccatc     1380

atggccaaag ttaagccaac tgtcttcctc ctcaaaccta cttttcctgg gatgtgggtt     1440

cttcatcctg cagatgacaa agaggcctca tctctaaagt cagaacctgg gtgtgggtct     1500

ccatcttgac ccccctccct tctctagatc ccataaatta ctagctcttg tccctccttc     1560

tcctaagcag ggctcatctt gatgcccttt tctccatcct gaccctggtc attcttgcgg     1620

cctcacctct tccctgatca ctgaaccctt ttcacctcct gcctccatct ctccccaaca     1680

caggcctcca gactgtactt ccagatgtct cctcatccag ttcctccaca gtctgaatgg     1740

ccatgtttcc tcttcattgc tggagaatga agtgcaaatg ccactgcctg gactgaaggc     1800

ctttcacgat ctgtcttctg ctggactctg ctcctgatcc cccttctcct tgcatcaccc     1860

gaagtctccc tacacccacc aggccaagcc ctctgtgatt ctgagacttt gcatgtgtag     1920

ttacttctcc tgaaatggcc ttcctcccca ttcctgccaa tccaggtcct tatcatcctt     1980

caggttgtct taaatgtcat ccaggtgtgt gtatttttat gtaatccttg tatgatatta     2040

agcggagatg tggcatttgt tcattaattt gtagacatat tcagtaacca tactgaatac     2100

atataatgac tatgtgccag catttccgta tgtgcagaag ttcatcaata gatatagact     2160

caaagagctc tgtcatcaag ctgttgttct gaagagcaga aggatacaaa taaaaagaaa     2220

taagtaaaat aaaaaaaaaa aaaaaaaaaa a                                    2251


<210>  13
<211>  790
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Ala Glu Gln Val Leu Pro Gln Ala Leu Tyr Leu Ser Asn Met Arg 
1               5                   10                  15      


Lys Ala Val Lys Ile Arg Glu Arg Thr Pro Glu Asp Ile Phe Lys Pro 
            20                  25                  30          


Thr Asn Gly Ile Ile His His Phe Lys Thr Met His Arg Tyr Thr Leu 
        35                  40                  45              


Glu Met Phe Arg Thr Cys Gln Phe Cys Pro Gln Phe Arg Glu Ile Ile 
    50                  55                  60                  


His Lys Ala Leu Ile Asp Arg Asn Ile Gln Ala Thr Leu Glu Ser Gln 
65                  70                  75                  80  


Lys Lys Leu Asn Trp Cys Arg Glu Val Arg Lys Leu Val Ala Leu Lys 
                85                  90                  95      


Thr Asn Gly Asp Gly Asn Cys Leu Met His Ala Thr Ser Gln Tyr Met 
            100                 105                 110         


Trp Gly Val Gln Asp Thr Asp Leu Val Leu Arg Lys Ala Leu Phe Ser 
        115                 120                 125             


Thr Leu Lys Glu Thr Asp Thr Arg Asn Phe Lys Phe Arg Trp Gln Leu 
    130                 135                 140                 


Glu Ser Leu Lys Ser Gln Glu Phe Val Glu Thr Gly Leu Cys Tyr Asp 
145                 150                 155                 160 


Thr Arg Asn Trp Asn Asp Glu Trp Asp Asn Leu Ile Lys Met Ala Ser 
                165                 170                 175     


Thr Asp Thr Pro Met Ala Arg Ser Gly Leu Gln Tyr Asn Ser Leu Glu 
            180                 185                 190         


Glu Ile His Ile Phe Val Leu Cys Asn Ile Leu Arg Arg Pro Ile Ile 
        195                 200                 205             


Val Ile Ser Asp Lys Met Leu Arg Ser Leu Glu Ser Gly Ser Asn Phe 
    210                 215                 220                 


Ala Pro Leu Lys Val Gly Gly Ile Tyr Leu Pro Leu His Trp Pro Ala 
225                 230                 235                 240 


Gln Glu Cys Tyr Arg Tyr Pro Ile Val Leu Gly Tyr Asp Ser His His 
                245                 250                 255     


Phe Val Pro Leu Val Thr Leu Lys Asp Ser Gly Pro Glu Ile Arg Ala 
            260                 265                 270         


Val Pro Leu Val Asn Arg Asp Arg Gly Arg Phe Glu Asp Leu Lys Val 
        275                 280                 285             


His Phe Leu Thr Asp Pro Glu Asn Glu Met Lys Glu Lys Leu Leu Lys 
    290                 295                 300                 


Glu Tyr Leu Met Val Ile Glu Ile Pro Val Gln Gly Trp Asp His Gly 
305                 310                 315                 320 


Thr Thr His Leu Ile Asn Ala Ala Lys Leu Asp Glu Ala Asn Leu Pro 
                325                 330                 335     


Lys Glu Ile Asn Leu Val Asp Asp Tyr Phe Glu Leu Val Gln His Glu 
            340                 345                 350         


Tyr Lys Lys Trp Gln Glu Asn Ser Glu Gln Gly Arg Arg Glu Gly His 
        355                 360                 365             


Ala Gln Asn Pro Met Glu Pro Ser Val Pro Gln Leu Ser Leu Met Asp 
    370                 375                 380                 


Val Lys Cys Glu Thr Pro Asn Cys Pro Phe Phe Met Ser Val Asn Thr 
385                 390                 395                 400 


Gln Pro Leu Cys His Glu Cys Ser Glu Arg Arg Gln Lys Asn Gln Asn 
                405                 410                 415     


Lys Leu Pro Lys Leu Asn Ser Lys Pro Gly Pro Glu Gly Leu Pro Gly 
            420                 425                 430         


Met Ala Leu Gly Ala Ser Arg Gly Glu Ala Tyr Glu Pro Leu Ala Trp 
        435                 440                 445             


Asn Pro Glu Glu Ser Thr Gly Gly Pro His Ser Ala Pro Pro Thr Ala 
    450                 455                 460                 


Pro Ser Pro Phe Leu Phe Ser Glu Thr Thr Ala Met Lys Cys Arg Ser 
465                 470                 475                 480 


Pro Gly Cys Pro Phe Thr Leu Asn Val Gln His Asn Gly Phe Cys Glu 
                485                 490                 495     


Arg Cys His Asn Ala Arg Gln Leu His Ala Ser His Ala Pro Asp His 
            500                 505                 510         


Thr Arg His Leu Asp Pro Gly Lys Cys Gln Ala Cys Leu Gln Asp Val 
        515                 520                 525             


Thr Arg Thr Phe Asn Gly Ile Cys Ser Thr Cys Phe Lys Arg Thr Thr 
    530                 535                 540                 


Ala Glu Ala Ser Ser Ser Leu Ser Thr Ser Leu Pro Pro Ser Cys His 
545                 550                 555                 560 


Gln Arg Ser Lys Ser Asp Pro Ser Arg Leu Val Arg Ser Pro Ser Pro 
                565                 570                 575     


His Ser Cys His Arg Ala Gly Asn Asp Ala Pro Ala Gly Cys Leu Ser 
            580                 585                 590         


Gln Ala Ala Arg Thr Pro Gly Asp Arg Thr Gly Thr Ser Lys Cys Arg 
        595                 600                 605             


Lys Ala Gly Cys Val Tyr Phe Gly Thr Pro Glu Asn Lys Gly Phe Cys 
    610                 615                 620                 


Thr Leu Cys Phe Ile Glu Tyr Arg Glu Asn Lys His Phe Ala Ala Ala 
625                 630                 635                 640 


Ser Gly Lys Val Ser Pro Thr Ala Ser Arg Phe Gln Asn Thr Ile Pro 
                645                 650                 655     


Cys Leu Gly Arg Glu Cys Gly Thr Leu Gly Ser Thr Met Phe Glu Gly 
            660                 665                 670         


Tyr Cys Gln Lys Cys Phe Ile Glu Ala Gln Asn Gln Arg Phe His Glu 
        675                 680                 685             


Ala Lys Arg Thr Glu Glu Gln Leu Arg Ser Ser Gln Arg Arg Asp Val 
    690                 695                 700                 


Pro Arg Thr Thr Gln Ser Thr Ser Arg Pro Lys Cys Ala Arg Ala Ser 
705                 710                 715                 720 


Cys Lys Asn Ile Leu Ala Cys Arg Ser Glu Glu Leu Cys Met Glu Cys 
                725                 730                 735     


Gln His Pro Asn Gln Arg Met Gly Pro Gly Ala His Arg Gly Glu Pro 
            740                 745                 750         


Ala Pro Glu Asp Pro Pro Lys Gln Arg Cys Arg Ala Pro Ala Cys Asp 
        755                 760                 765             


His Phe Gly Asn Ala Lys Cys Asn Gly Tyr Cys Asn Glu Cys Phe Gln 
    770                 775                 780                 


Phe Lys Gln Met Tyr Gly 
785                 790 


<210>  14
<211>  4705
<212>  DNA
<213>  Homo sapiens

<400>  14
ctttggaaag tcccgtggaa atccccgggc ctacaacccg catacaactg aaacggggca       60

aagcagactg cgcagtctgc agtcttcgtg gcgggccaag cgagcttgga gcccgcgggg      120

gcggagcggt gagagcggcc gccaagagag atcacacccc cagccgaccc tgccagcgag      180

cgagcccgac cccaggcgtc catggagcgt cgcctccgcc cggtccctgc cccgaccccc      240

gcctgcggcg cgctcctgcc ttgaccagga cttgggactt tgcgaaagga tcgcggggcc      300

cggagaggtg ttggagagca caatggctga acaagtcctt cctcaggctt tgtatttgag      360

caatatgcgg aaagctgtga agatacggga gagaactcca gaagacattt ttaaacctac      420

taatgggatc attcatcatt ttaaaaccat gcaccgatac acactggaaa tgttcagaac      480

ttgccagttt tgtcctcagt ttcgggagat catccacaaa gccctcatcg acagaaacat      540

ccaggccacc ctggaaagcc agaagaaact caactggtgt cgagaagtcc ggaagcttgt      600

ggcgctgaaa acgaacggtg acggcaattg cctcatgcat gccacttctc agtacatgtg      660

gggcgttcag gacacagact tggtactgag gaaggcgctg ttcagcacgc tcaaggaaac      720

agacacacgc aactttaaat tccgctggca actggagtct ctcaaatctc aggaatttgt      780

tgaaacgggg ctttgctatg atactcggaa ctggaatgat gaatgggaca atcttatcaa      840

aatggcttcc acagacacac ccatggcccg aagtggactt cagtacaact cactggaaga      900

aatacacata tttgtccttt gcaacatcct cagaaggcca atcattgtca tttcagacaa      960

aatgctaaga agtttggaat caggttccaa tttcgcccct ttgaaagtgg gtggaattta     1020

cttgcctctc cactggcctg cccaggaatg ctacagatac cccattgttc tcggctatga     1080

cagccatcat tttgtaccct tggtgaccct gaaggacagt gggcctgaaa tccgagctgt     1140

tccacttgtt aacagagacc ggggaagatt tgaagactta aaagttcact ttttgacaga     1200

tcctgaaaat gagatgaagg agaagctctt aaaagagtac ttaatggtga tagaaatccc     1260

cgtccaaggc tgggaccatg gcacaactca tctcatcaat gccgcaaagt tggatgaagc     1320

taacttacca aaagaaatca atctggtaga tgattacttt gaacttgttc agcatgagta     1380

caagaaatgg caggaaaaca gcgagcaggg gaggagagag gggcacgccc agaatcccat     1440

ggaaccttcc gtgccccagc tttctctcat ggatgtaaaa tgtgaaacgc ccaactgccc     1500

cttcttcatg tctgtgaaca cccagccttt atgccatgag tgctcagaga ggcggcaaaa     1560

gaatcaaaac aaactcccaa agctgaactc caagccgggc cctgaggggc tccctggcat     1620

ggcgctcggg gcctctcggg gagaagccta tgagcccttg gcgtggaacc ctgaggagtc     1680

cactgggggg cctcattcgg ccccaccgac agcacccagc ccttttctgt tcagtgagac     1740

cactgccatg aagtgcagga gccccggctg ccccttcaca ctgaatgtgc agcacaacgg     1800

attttgtgaa cgttgccaca acgcccggca acttcacgcc agccacgccc cagaccacac     1860

aaggcacttg gatcccggga agtgccaagc ctgcctccag gatgttacca ggacatttaa     1920

tgggatctgc agtacttgct tcaaaaggac tacagcagag gcctcctcca gcctcagcac     1980

cagcctccct ccttcctgtc accagcgttc caagtcagat ccctcgcggc tcgtccggag     2040

cccctccccg cattcttgcc acagagctgg aaacgacgcc cctgctggct gcctgtctca     2100

agctgcacgg actcctgggg acaggacggg gacgagcaag tgcagaaaag ccggctgcgt     2160

gtattttggg actccagaaa acaagggctt ttgcacactg tgtttcatcg agtacagaga     2220

aaacaaacat tttgctgctg cctcagggaa agtcagtccc acagcgtcca ggttccagaa     2280

caccattccg tgcctgggga gggaatgcgg cacccttgga agcaccatgt ttgaaggata     2340

ctgccagaag tgtttcattg aagctcagaa tcagagattt catgaggcca aaaggacaga     2400

agagcaactg agatcgagcc agcgcagaga tgtgcctcga accacacaaa gcacctcaag     2460

gcccaagtgc gcccgggcct cctgcaagaa catcctggcc tgccgcagcg aggagctctg     2520

catggagtgt cagcatccca accagaggat gggccctggg gcccaccggg gtgagcctgc     2580

ccccgaagac ccccccaagc agcgttgccg ggcccccgcc tgtgatcatt ttggcaatgc     2640

caagtgcaac ggctactgca acgaatgctt tcagttcaag cagatgtatg gctaaccgga     2700

aacaggtggg tcacctcctg caagaagtgg ggcctcgagc tgtcagtcat catggtgcta     2760

tcctctgaac ccctcagctg ccactgcaac agtgggctta agggtgtctg agcaggagag     2820

gaaagataag ctcttcgtgg tgcccacgat gctcaggttt ggtaacccgg gagtgttccc     2880

aggtggcctt agaaagcaaa gcttgtaact ggcaagggat gatgtcagat tcagcccaag     2940

gttcctcctc tcctaccaag caggaggcca ggaacttctt tggacttgga aggtgtgcgg     3000

ggactggccg aggcccctgc accctgcgca tcaggactgc ttcatcgtct tggctgagaa     3060

agggaaaaga cacacaagtc gcgtgggttg gagaagccag agccattcca cctcccctcc     3120

cccagcatct ctcagagatg tgaagccaga tcctcatggc agcgaggccc tctgcaagaa     3180

gctcaaggaa gctcagggaa aatggacgta ttcagagagt gtttgtagtt catggttttt     3240

ccctacctgc ccggttcctt tcctgaggac ccggcagaaa tgcagaacca tccatggact     3300

gtgattctga ggctgctgag actgaacatg ttcacattga cagaaaaaca agctgctctt     3360

tataatatgc accttttaaa aaattagaat attttactgg gaagacgtgt aactctttgg     3420

gttattactg tctttacttc taaagaagtt agcttgaact gaggagtaaa agtgtgtaca     3480

tatataatat acccttacat tatgtatgag ggattttttt aaattatatt gaaatgctgc     3540

cctagaagta caataggaag gctaaataat aataacctgt tttctggttg ttgttggggc     3600

atgagcttgt gtatacactg cttgcataaa ctcaaccagc tgccttttta aagggagctc     3660

tagtcctttt tgtgtaattc actttattta ttttattaca aacttcaaga ttatttaagt     3720

gaagatattt cttcagctct ggggaaaatg ccacagtgtt ctcctgagag aacatccttg     3780

ctttgagtca ggctgtgggc aagttcctga ccacagggag taaattggcc tctttgatac     3840

acttttgctt gcctccccag gaaagaagga attgcatcca aggtatacat acatattcat     3900

cgatgtttcg tgcttctcct tatgaaactc cagctatgta ataaaaaact atactctgtg     3960

ttctgttaat gcctctgagt gtcctacctc cttggagatg agatagggaa ggagcaggga     4020

tgagactggc aatggtcaca gggaaagatg tggccttttg tgatggtttt attttctgtt     4080

aacactgtgt cctggggggg ctgggaagtc ccctgcatcc catggtaccc tggtattggg     4140

acagcaaaag ccagtaacca tgagtatgag gaaatctctt tctgttgctg gcttacagtt     4200

tctctgtgtg ctttgtggtt gctgtcatat ttgctctaga agaaaaaaaa aaaaggaggg     4260

gaaatgcatt ttccccagag ataaaggctg ccattttggg ggtctgtact tatggcctga     4320

aaatatttgt gatccataac tctacacagc ctttactcat actattaggc acactttccc     4380

cttagagccc cctaagtttt tcccagacga atctttataa tttctttcca aagataccaa     4440

ataaacttca gtgttttcat ctaattctct taaagttgat atcttaatat tttgtgttga     4500

tcattatttc cattcttaat gtgaaaaaaa gtaattattt atacttatta taaaaagtat     4560

ttgaaatttg cacatttaat tgtccctaat agaaagccac ctattctttg ttggatttct     4620

tcaagttttt ctaaataaat gtaacttttc acaagagtca acattaaaaa ataaattatt     4680

taagaacaga aaaaaaaaaa aaaaa                                           4705


<210>  15
<211>  129
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Ala Arg Gly Ser Leu Arg Arg Leu Leu Arg Leu Leu Val Leu Gly 
1               5                   10                  15      


Leu Trp Leu Ala Leu Leu Arg Ser Val Ala Gly Glu Gln Ala Pro Gly 
            20                  25                  30          


Thr Ala Pro Cys Ser Arg Gly Ser Ser Trp Ser Ala Asp Leu Asp Lys 
        35                  40                  45              


Cys Met Asp Cys Ala Ser Cys Arg Ala Arg Pro His Ser Asp Phe Cys 
    50                  55                  60                  


Leu Gly Cys Ala Ala Ala Pro Pro Ala Pro Phe Arg Leu Leu Trp Pro 
65                  70                  75                  80  


Ile Leu Gly Gly Ala Leu Ser Leu Thr Phe Val Leu Gly Leu Leu Ser 
                85                  90                  95      


Gly Phe Leu Val Trp Arg Arg Cys Arg Arg Arg Glu Lys Phe Thr Thr 
            100                 105                 110         


Pro Ile Glu Glu Thr Gly Gly Glu Gly Cys Pro Ala Val Ala Leu Ile 
        115                 120                 125             


Gln 
    


<210>  16
<211>  1048
<212>  DNA
<213>  Homo sapiens

<400>  16
aaggcggggg cgggggcggg gcggcggccg tgggtccctg ccggccggcg gcgggcgcag       60

acagcggcgg gcgcaggacg tgcactatgg ctcggggctc gctgcgccgg ttgctgcggc      120

tcctcgtgct ggggctctgg ctggcgttgc tgcgctccgt ggccggggag caagcgccag      180

gcaccgcccc ctgctcccgc ggcagctcct ggagcgcgga cctggacaag tgcatggact      240

gcgcgtcttg cagggcgcga ccgcacagcg acttctgcct gggctgcgct gcagcacctc      300

ctgccccctt ccggctgctt tggcccatcc ttgggggcgc tctgagcctg accttcgtgc      360

tggggctgct ttctggcttt ttggtctgga gacgatgccg caggagagag aagttcacca      420

cccccataga ggagaccggc ggagagggct gcccagctgt ggcgctgatc cagtgacaat      480

gtgccccctg ccagccgggg ctcgcccact catcattcat tcatccattc tagagccagt      540

ctctgcctcc cagacgcggc gggagccaag ctcctccaac cacaaggggg gtggggggcg      600

gtgaatcacc tctgaggcct gggcccaggg ttcaggggaa ccttccaagg tgtctggttg      660

ccctgcctct ggctccagaa cagaaaggga gcctcacgct ggctcacaca aaacagctga      720

cactgactaa ggaactgcag catttgcaca ggggaggggg gtgccctcct tcctagaggc      780

cctgggggcc aggctgactt ggggggcaga cttgacacta ggccccactc actcagatgt      840

cctgaaattc caccacgggg gtcaccctgg ggggttaggg acctattttt aacactaggg      900

ggctggccca ctaggagggc tggccctaag atacagaccc ccccaactcc ccaaagcggg      960

gaggagatat ttattttggg gagagtttgg aggggaggga gaatttatta ataaaagaat     1020

ctttaacttt aaaaaaaaaa aaaaaaaa                                        1048


<210>  17
<211>  706
<212>  PRT
<213>  Homo sapiens

<400>  17

Met Glu Glu Asn Pro Thr Leu Glu Ser Glu Ala Trp Gly Ser Ser Arg 
1               5                   10                  15      


Glu Trp Leu Ala Pro Arg Glu Ala Arg Gly Gly Pro Ser Leu Ser Ser 
            20                  25                  30          


Val Leu Asn Glu Leu Pro Ser Ala Ala Thr Leu Arg Tyr Arg Asp Pro 
        35                  40                  45              


Gly Val Leu Pro Trp Gly Ala Leu Glu Glu Glu Glu Glu Asp Gly Gly 
    50                  55                  60                  


Arg Ser Arg Lys Ala Phe Thr Glu Val Thr Gln Thr Glu Leu Gln Asp 
65                  70                  75                  80  


Pro His Pro Ser Arg Glu Leu Pro Trp Pro Met Gln Ala Arg Arg Ala 
                85                  90                  95      


His Arg Gln Arg Asn Ala Ser Arg Asp Gln Val Val Tyr Gly Ser Gly 
            100                 105                 110         


Thr Lys Thr Asp Arg Trp Ala Arg Leu Leu Arg Arg Ser Lys Glu Lys 
        115                 120                 125             


Thr Lys Glu Gly Leu Arg Ser Leu Gln Pro Trp Ala Trp Thr Leu Lys 
    130                 135                 140                 


Arg Ile Gly Gly Gln Phe Gly Ala Gly Thr Glu Ser Tyr Phe Ser Leu 
145                 150                 155                 160 


Leu Arg Phe Leu Leu Leu Leu Asn Val Leu Ala Ser Val Leu Met Ala 
                165                 170                 175     


Cys Met Thr Leu Leu Pro Thr Trp Leu Gly Gly Ala Pro Pro Gly Pro 
            180                 185                 190         


Pro Gly Pro Asp Ile Ser Ser Pro Cys Gly Ser Tyr Asn Pro His Ser 
        195                 200                 205             


Gln Gly Leu Val Thr Phe Ala Thr Gln Leu Phe Asn Leu Leu Ser Gly 
    210                 215                 220                 


Glu Gly Tyr Leu Glu Trp Ser Pro Leu Phe Tyr Gly Phe Tyr Pro Pro 
225                 230                 235                 240 


Arg Pro Arg Leu Ala Val Thr Tyr Leu Cys Trp Ala Phe Ala Val Gly 
                245                 250                 255     


Leu Ile Cys Leu Leu Leu Ile Leu His Arg Ser Val Ser Gly Leu Lys 
            260                 265                 270         


Gln Thr Leu Leu Ala Glu Ser Glu Ala Leu Thr Ser Tyr Ser His Arg 
        275                 280                 285             


Val Phe Ser Ala Trp Asp Phe Gly Leu Cys Gly Asp Val His Val Arg 
    290                 295                 300                 


Leu Arg Gln Arg Ile Ile Leu Tyr Glu Leu Lys Val Glu Leu Glu Glu 
305                 310                 315                 320 


Thr Val Val Arg Arg Gln Ala Ala Val Arg Thr Leu Gly Gln Gln Ala 
                325                 330                 335     


Arg Val Trp Leu Val Arg Val Leu Leu Asn Leu Leu Val Val Ala Leu 
            340                 345                 350         


Leu Gly Ala Ala Phe Tyr Gly Val Tyr Trp Ala Thr Gly Cys Thr Val 
        355                 360                 365             


Glu Leu Gln Glu Met Pro Leu Val Gln Glu Leu Pro Leu Leu Lys Leu 
    370                 375                 380                 


Gly Val Asn Tyr Leu Pro Ser Ile Phe Ile Ala Gly Val Asn Phe Val 
385                 390                 395                 400 


Leu Pro Pro Val Phe Lys Leu Ile Ala Pro Leu Glu Gly Tyr Thr Arg 
                405                 410                 415     


Ser Arg Gln Ile Val Phe Ile Leu Leu Arg Thr Val Phe Leu Arg Leu 
            420                 425                 430         


Ala Ser Leu Val Val Leu Leu Phe Ser Leu Trp Asn Gln Ile Thr Cys 
        435                 440                 445             


Gly Gly Asp Ser Glu Ala Glu Asp Cys Lys Thr Cys Gly Tyr Asn Tyr 
    450                 455                 460                 


Lys Gln Leu Pro Cys Trp Glu Thr Val Leu Gly Gln Glu Met Tyr Lys 
465                 470                 475                 480 


Leu Leu Leu Phe Asp Leu Leu Thr Val Leu Ala Val Ala Leu Leu Ile 
                485                 490                 495     


Gln Phe Pro Arg Lys Leu Leu Cys Gly Leu Cys Pro Gly Ala Leu Gly 
            500                 505                 510         


Arg Leu Ala Gly Thr Gln Glu Phe Gln Val Pro Asp Glu Val Leu Gly 
        515                 520                 525             


Leu Ile Tyr Ala Gln Thr Val Val Trp Val Gly Ser Phe Phe Cys Pro 
    530                 535                 540                 


Leu Leu Pro Leu Leu Asn Thr Val Lys Phe Leu Leu Leu Phe Tyr Leu 
545                 550                 555                 560 


Lys Lys Leu Thr Leu Phe Ser Thr Cys Ser Pro Ala Ala Arg Thr Phe 
                565                 570                 575     


Arg Ala Ser Ala Ala Asn Phe Phe Phe Pro Leu Val Leu Leu Leu Gly 
            580                 585                 590         


Leu Ala Ile Ser Ser Val Pro Leu Leu Tyr Ser Ile Phe Leu Ile Pro 
        595                 600                 605             


Pro Ser Lys Leu Cys Gly Pro Phe Arg Gly Gln Ser Ser Ile Trp Ala 
    610                 615                 620                 


Gln Ile Pro Glu Ser Ile Ser Ser Leu Pro Glu Thr Thr Gln Asn Phe 
625                 630                 635                 640 


Leu Phe Phe Leu Gly Thr Gln Ala Phe Ala Val Pro Leu Leu Leu Ile 
                645                 650                 655     


Ser Ser Ile Leu Met Ala Tyr Thr Val Ala Leu Ala Asn Ser Tyr Gly 
            660                 665                 670         


Arg Leu Ile Ser Glu Leu Lys Arg Gln Arg Glu Thr Glu Ala Gln Asn 
        675                 680                 685             


Lys Val Phe Leu Ala Arg Arg Ala Val Ala Leu Thr Ser Thr Lys Pro 
    690                 695                 700                 


Ala Leu 
705     


<210>  18
<211>  2477
<212>  DNA
<213>  Homo sapiens

<400>  18
ctgagaaacc acaggaagtg taccttactc cctccgggcc acctgctggc caggtacaca       60

cctgcccctg gcccctccct tacctggggc agtgtctgcc tggtggccac tagagacagc      120

ccagcctggg gccatggaag aaaacccgac cttggaatca gaagcctggg gctcctctag      180

ggagtggctg gccccccggg aggccagagg aggcccatcg ctgtcttctg tgctgaacga      240

gctgcccagt gctgccaccc ttcggtaccg agaccctggg gtgctgcctt ggggggcgct      300

ggaggaggag gaggaggatg gaggaaggag cagaaaggcc ttcacagaag tcacccagac      360

agagctgcag gaccctcacc cttcccggga actgccctgg cccatgcagg ccagacgggc      420

acacaggcaa agaaatgcca gcagggacca ggtggtctat ggctctggaa ctaagacgga      480

ccgatgggcg cggctacttc ggaggtccaa ggagaaaaca aaggaaggct tgcgaagcct      540

gcagccctgg gcgtggacac tgaagaggat cgggggccag tttggcgccg gcacggagtc      600

ctacttctcc ctgctgcgct tcctgctcct tcttaacgtg ctggcctctg tgctcatggc      660

ctgcatgacg ctgctgccca cctggttggg aggcgctccc ccaggccctc ccggccccga      720

catctcctcg ccctgcggct cctataaccc ccactcccag ggcctggtca cctttgccac      780

ccagctcttc aacttgctct cgggtgaggg ttacctggaa tggtcccctc tcttctatgg      840

cttctacccg ccccgcccac gcctggcggt cacctacctg tgctgggcct ttgccgttgg      900

cctcatctgc ctcctgctca tcctgcatcg ctcggtgtct gggctgaagc agacactgct      960

ggcggagtcc gaggctctga ccagctacag ccaccgggtg ttctcggcct gggacttcgg     1020

tctctgcggg gacgtccacg tgcggctgcg ccagcgcatc atcttgtacg aattaaaggt     1080

ggagctggag gagacagtgg tgcggcgcca ggctgcggtg cggacgctgg gccagcaagc     1140

cagggtttgg ttggtgcggg tgctgctcaa cctgctggtg gtcgcgctcc tgggggcagc     1200

cttctatggc gtctactggg ctacggggtg caccgtggag ctgcaggaga tgccccttgt     1260

ccaggagttg ccactgctga agcttggggt gaattacctt ccgtccatct tcatcgctgg     1320

ggtcaatttt gtgctgccgc ccgtgttcaa gctcattgct ccactggagg gctacactcg     1380

gagtcgccag atcgttttta tcctgctcag gaccgtgttt cttcgcctcg cctccctggt     1440

ggtcctgctc ttctctctct ggaatcagat cacttgtggg ggcgactccg aggctgagga     1500

ctgcaaaacc tgtggctaca attacaaaca acttccgtgc tgggagactg tcctgggcca     1560

ggaaatgtac aaacttctgc tctttgatct gctgactgtc ttggcagtcg cgctgctcat     1620

ccagtttcct agaaagctcc tctgtggcct ctgtcctggg gcgctgggtc gtctggcggg     1680

gacccaagag ttccaggtgc ccgacgaggt gctggggctc atctacgcgc agacggtggt     1740

ctgggtgggg agttttttct gccctttact gcccctgctt aacacggtca agttcctgct     1800

gcttttctac ctgaagaagc ttaccctctt ctccacctgc tccccggctg cccgcacctt     1860

ccgggcctcc gcggcgaatt tctttttccc cttggtcctt ctcctgggtc tggccatctc     1920

cagcgttccc ctgctttaca gcatcttcct gatcccgcct tctaagctgt gtggtccatt     1980

ccgggggcag tcgtccatct gggcccagat ccctgagtct atttccagcc tccctgagac     2040

cacccagaat ttcctcttct tcctggggac ccaggctttt gctgtgcccc ttctgctgat     2100

ctccagcatc ctgatggcgt acactgtggc tctggctaac tcctacggac gcctcatctc     2160

tgagctcaaa cgtcagagag agacggaggc gcagaataaa gtcttcctgg cacggcgcgc     2220

tgtggcgctg acctccacca aaccggctct ttgacccccg cagcccacgt cccgctttca     2280

gaccccaggc ccattgtaag cctaggtcac aacatctgta aactaggaga actggagaag     2340

actccacgcc cttccagctt tggtatctgg agatttccag ggcccctcgc cgccacgtcc     2400

ctgactctcg ggtgatcttc cttgtatcaa taaatacagc cgaggttgct gagcgcgctt     2460

tgaaaaaaaa aaaaaaa                                                    2477


