                         SEQUENCE LISTING

<110>  NGM BIOPHARMACEUTICALS, INC.
 
<120>  BINDING PROTEINS AND METHODS OF USE THEREOF

<130>  13370-027-228

<140>  To Be Assigned
<141>  Herewith

<150>  62/316,516
<151>  2016-03-31

<160>  2008  

<170>  PatentIn version 3.5


<210>  1
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH sequence - 1C1

<400> 1

Gln Met Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Asn Asp Tyr 
            20                  25                  30          


Gly Val His Trp Ile Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Ser Gly Gly Arg Thr Asp Tyr Asn Ala Ala Phe Ile 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Phe Phe 
65                  70                  75                  80  


Lys Met Ser Ser Leu Gln Pro Gln Asp Thr Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Trp Ala Leu Tyr Phe Leu Tyr Gly Gly Ser Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120     


<210>  2
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL sequence - 1C1

<400> 2

Asp Val Val Leu Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Pro Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Ser Gly Ile Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Leu Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser 
                85                  90                  95      


Thr His Val Pro Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  3
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH sequence - 3P10

<400> 3

Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Gly Val Ile Trp Val Lys Gln Ala Pro Gly Lys Ala Leu Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Asp Leu 
    50                  55                  60                  


Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Ser Ala Ser 
65                  70                  75                  80  


Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Arg Tyr Gly Pro Glu Asp Ile Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Leu Thr Val Ser Ser 
        115             


<210>  4
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL sequence - 3P10

<400> 4

Asp Ile Val Leu Thr Gln Ser Pro Val Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Asn Tyr 
            20                  25                  30          


Gly Ile Ser Phe Met Ser Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Ala Ala Ser His Gln Gly Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu Asn Ile His 
65                  70                  75                  80  


Pro Met Glu Glu Asp Asp Ser Ala Met Tyr Phe Cys Leu Gln Ser Lys 
                85                  90                  95      


Glu Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  5
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH sequence - 12A3

<400> 5

Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Pro Phe Thr Ile Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Glu Gln Ala Pro Gly Lys Gly Leu Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Ser Gly Val Pro Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Asn Asn Leu Lys Asp Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Ser Ala Thr Gly Asn Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  6
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL sequence - 12A3


<400> 6

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Ser Leu Thr Cys Arg Ala Ser Gln Asp Ile Gly Ser Ser 
            20                  25                  30          


Leu Asn Trp Leu Gln Gln Glu Pro Asp Gly Thr Ile Lys Arg Leu Ile 
        35                  40                  45              


Tyr Ala Thr Ser Ser Leu Asp Ser Gly Val Pro Lys Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Ser Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Ser 
65                  70                  75                  80  


Glu Asp Phe Val Asp Tyr Tyr Cys Leu Gln Tyr Ala Ser Ser Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  7
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH sequence - 5F12


<400> 7

Gln Val Gln Leu Lys Gln Ser Gly Thr Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Ile Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Ala Arg Ile Tyr Pro Gly Asn Gly Asn Thr Tyr His Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Glu Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Glu Gly Leu Tyr Tyr Asp Tyr Asp Arg Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Ala Leu Thr Val Ser Ser 
        115                 120         


<210>  8
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL sequence - 5F12

<400> 8

Asn Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Thr Tyr 
            20                  25                  30          


Gly Asn Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asp 
65                  70                  75                  80  


Pro Val Glu Ala Asp Asp Ala Ala Thr Tyr Tyr Cys His Gln Asn Asn 
                85                  90                  95      


Glu Asp Pro Pro Ala Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  9
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH sequence - 5A20

<400> 9

Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Met Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Ile Leu Ser Cys Lys Ala Ile Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Trp Ile Glu Trp Val Lys Glu Arg Pro Gly His Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Leu Leu Gly Ser Asp Ser Ile His Phe Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Ile Ser Ala Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Thr Glu Asp Ser Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Val Arg Gln Asp Trp Asn Trp Tyr Phe Asp Val Trp Gly Thr Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  10
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL sequence - 5A20

<400> 10

Asp Val Val Met Thr Gln Thr Pro Leu Thr Leu Ser Val Thr Ile Gly 
1               5                   10                  15      


His Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Asp Phe 
            20                  25                  30          


Asp Gly Lys Thr Tyr Leu Asn Trp Leu Phe Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Arg Leu Phe Tyr Leu Val Ser Lys Leu Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Trp Gln Gly 
                85                  90                  95      


Thr His Phe Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  11
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH sequence - 8D8

<400> 11

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Arg Tyr 
            20                  25                  30          


Ser Val His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Met Ile Trp Gly Phe Gly Ser Thr Asp Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Thr Lys Asp Asn Ser Lys Ser Gln Phe Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ile His Thr Thr Ala Gly Ser Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ala 
        115     


<210>  12
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL sequence - 8D8

<400> 12

Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser Thr Ser Ile Gly 
1               5                   10                  15      


Asp Arg Val Ser Val Thr Cys Lys Ala Ser Gln Asn Val Gly Thr Asn 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Ala Leu Val 
        35                  40                  45              


Tyr Ser Thr Ser Tyr Arg Tyr Ser Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Glu Tyr Phe Cys His Gln Tyr Asn Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  13
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH sequence - 17J16

<400> 13

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Trp Ile His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Asn Ser Asn Tyr Ala Glu Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Val Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Leu Ser Arg Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Asp Trp Asn Trp Tyr Phe His Val Trp Gly Ala Gly Ser 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  14
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL sequence - 17J16

<400> 14

Asp Val Ala Leu Thr Gln Ile Pro Leu Thr Leu Ser Val Thr Val Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Ser Asp Ser 
            20                  25                  30          


Asp Gly Lys Thr Tyr Leu Asn Trp Leu Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Arg Leu Ile Tyr Leu Val Ser Arg Leu Gly Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Thr Gly Ser Gly Ser Gly Ala Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Trp Gln Gly 
                85                  90                  95      


Thr His Phe Pro Gln Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  15
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH sequence - 25M22

<400> 15

Gln Val Gln Leu Gln Gln Ser Gly Pro Asp Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Val Asn Trp Met Lys Gln Arg Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Tyr Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ala Tyr Leu Leu Arg Leu Arg Arg Thr Gly Tyr Tyr Ala Met 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120                 125 


<210>  16
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL sequence - 25M22

<400> 16

Asp Val Val Leu Thr Gln Thr Pro Leu Ser Leu Pro Val Asn Ile Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Lys Ser Thr Lys Ser Leu Leu Asn Ser 
            20                  25                  30          


Asp Glu Phe Thr Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Phe Leu Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Ser 
                85                  90                  95      


Asn Tyr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  17
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH sequence - 2B8

<400> 17

Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Lys Gln Ala Pro Gly Lys Ile Phe Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Ser Gly Val Pro Thr Phe Val Asp Asp Phe 
    50                  55                  60                  


Arg Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Gly Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Arg Ser Ser Tyr Tyr Pro Tyr Trp Tyr Phe Asp Val Trp Gly 
            100                 105                 110         


Thr Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  18
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL sequence - 2B8

<400> 18

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Glu Thr Val Thr Ile Thr Cys Arg Pro Ser Glu Asn Ile Tyr Ser Tyr 
            20                  25                  30          


Leu Thr Trp Phe Gln Gln Glu Gln Gly Lys Ser Pro Gln Leu Leu Val 
        35                  40                  45              


Tyr Asn Ala Gln Thr Leu Ala Glu Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr His Phe Ser Leu Lys Ile Asn Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Gly Thr Tyr Tyr Cys Gln His Tyr Tyr Gly Tyr Pro Phe 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  19
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH sequence - 22N5

<400> 19

Gln Asn Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ile Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ser Met His Trp Val Lys Lys Thr Pro Gly Lys Gly Phe Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Glu Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Asn Thr Ala His 
65                  70                  75                  80  


Leu Gln Ile Thr Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Val Lys Gly Thr Leu Asn Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  20
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL sequence - 22N5

<400> 20

Asp Ile Lys Met Thr Gln Ser Pro Ser Ser Met Tyr Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Lys Ser Tyr 
            20                  25                  30          


Leu Asn Trp Phe Gln Gln Lys Pro Gly Lys Ser Pro Lys Thr Leu Ile 
        35                  40                  45              


Tyr Arg Thr Lys Arg Leu Val Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Val Ser Ser Leu Glu Tyr 
65                  70                  75                  80  


Asp Asp Val Gly Ile Tyr Tyr Cys Leu Gln Tyr Val Glu Phe Pro Leu 
                85                  90                  95      


Thr Phe Gly Asp Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  21
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH sequence - 2I23

<400> 21

Gln Ala Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Asn Ile Asp Trp Val Arg Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Phe Pro Gly Asp Gly Ser Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Gln Ala Thr Leu Thr Thr Asp Lys Ser Ser Ser Thr Thr Tyr 
65                  70                  75                  80  


Ile His Leu Ser Arg Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ser Gly Ile Tyr Tyr Gly Ser His Phe Val Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ala 
        115                 120 


<210>  22
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL sequence - 2I23

<400> 22

Asp Val Val Met Thr Gln Thr Pro Leu Thr Leu Ser Val Thr Ile Gly 
1               5                   10                  15      


Gln Ser Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu Asp Ser 
            20                  25                  30          


Asp Gly Lys Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Arg Leu Ile Tyr Leu Val Ser Lys Val Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Trp Gln Gly 
                85                  90                  95      


Thr His Phe Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110         


<210>  23
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH sequence - 6N16

<400> 23

Gln Val Gln Leu Gln Gln Ser Gly Ser Glu Leu Val Lys Pro Gly Thr 
1               5                   10                  15      


Ser Met Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Ile Asn Trp Val Arg Leu Arg Pro Glu Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Phe Pro Gly Asp Asp Ser Ile Lys Tyr Asn Glu Asn Phe 
    50                  55                  60                  


Arg Gly Lys Ala Thr Leu Thr Thr Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met His Leu Ser Arg Leu Thr Ser Asp Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ser Gly Ile Phe Tyr Gly Asn Asn Phe Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ala 
        115                 120 


<210>  24
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL sequence - 6N16

<400> 24

Asp Val Val Met Thr Gln Ala Pro Leu Ile Leu Ser Val Thr Ile Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Asp Gly 
            20                  25                  30          


Asp Gly Glu Thr Tyr Leu Ser Trp Leu Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Arg Leu Ile Tyr Leu Val Ser Lys Leu Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Cys Gln Ser 
                85                  90                  95      


Thr His Phe Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110         


<210>  25
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH sequence - 1B3

<400> 25

Gln Val His Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Phe Thr Phe Thr Gly Tyr 
            20                  25                  30          


Asn Ile Asn Trp Val Arg Leu Arg Pro Glu Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Phe Pro Gly Asp Asp Asn Ala Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Thr Asp Lys Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Arg Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Thr Pro Val Leu Ser Asn Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser Ser 
        115                 


<210>  26
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL sequence - 1B3

<400> 26

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Gly Lys Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          


Ile Ser Trp Tyr Gln His Lys Pro Gly Lys Ser Pro Arg Leu Leu Ile 
        35                  40                  45              


His Tyr Thr Ser Thr Leu Gln Pro Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Arg Asp Tyr Ser Phe Ser Ile Ser Asn Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Asn Leu Tyr Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  27
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH sequence - 19K19

<400> 27

Gln Val Gln Leu Gln Gln Ser Gly Pro Asp Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Lys Gln Arg Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Tyr Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ala Tyr Leu Leu Arg Leu Arg Arg Thr Gly Tyr Tyr Ala Met 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120                 125 


<210>  28
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL sequence - 19K19

<400> 28

Asp Val Val Leu Thr Gln Thr Pro Leu Ser Leu Pro Val Asn Ile Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Lys Ser Thr Lys Ser Leu Leu Asn Ser 
            20                  25                  30          


Asp Glu Phe Thr Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Leu Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Ser 
                85                  90                  95      


Asn Tyr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  29
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH sequence - 2B3

<400> 29

Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Phe Met Phe Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Asn Asp Gly Asp Ser Thr Tyr Tyr Pro Asp Thr Val 
    50                  55                  60                  


Gln Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Arg Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Gln Gly Ala Gln Ala Thr Leu Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Leu Thr Val Ser Ser 
        115             


<210>  30
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL sequence - 2B3

<400> 30

Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Leu Gly 
1               5                   10                  15      


Glu Glu Ile Thr Leu Thr Cys Ser Ala Ser Ser Ser Val Phe Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              


Ser Thr Ser Asn Leu Ala Ser Gly Ile Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Phe Tyr Ser Leu Thr Ile Ser Ser Val Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Asp Tyr Tyr Cys His Gln Trp Ser Ser Thr Phe Gly Gly 
                85                  90                  95      


Gly Thr Lys Leu Glu Ile Lys 
            100             


<210>  31
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH sequence - 8C10

<400> 31

Gln Val Gln Leu Gln Gln Ser Gly Val Glu Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ala Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ala Asn Tyr 
            20                  25                  30          


Gly Leu Thr Trp Val Lys Gln Arg Thr Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Tyr Pro Gly Ser Gly His Thr His Tyr Asn Glu Asp Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Arg Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Arg Ile Gln Leu Leu Leu Pro Val Gly Gly Phe Val Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ala 
        115                 120         


<210>  32
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL sequence - 8C10

<400> 32

Asp Phe Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Asp Ser Val Ser Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Asn Asn 
            20                  25                  30          


Leu His Trp Tyr Gln Gln Lys Ser His Glu Ser Pro Arg Leu Leu Ile 
        35                  40                  45              


Lys Tyr Ala Ser Gln Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Asn Ser Val Glu Thr 
65                  70                  75                  80  


Glu Asp Phe Gly Val Tyr Phe Cys Gln Gln Ser Asn Ser Trp Pro His 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  33
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH sequence - 2A9

<400> 33

Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Thr Ser Gly Gly Thr Thr Tyr Tyr Thr Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Asn Ile Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Gly Asn Phe Tyr Tyr Tyr Gly Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Ser Val Thr Val Ser Ser 
        115                 


<210>  34
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL sequence - 2A9

<400> 34

Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asn Val Gly Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Ile Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Asn Arg Phe Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Met Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr Ser Ser Tyr Phe Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys 
            100                 105     


<210>  35
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH sequence - 24G2

<400> 35

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Leu Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Tyr 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Met Ile His Pro Asn Ser Gly Ser Ser Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asn Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ser Asp Tyr Gly Phe Ile Pro Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120 


<210>  36
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL sequence - 24G2

<400> 36

Asp Ile Leu Leu Thr Gln Ser Pro Ala Ile Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Val Ser Phe Ser Cys Arg Ala Ser Gln Ser Ile Gly Thr Ser 
            20                  25                  30          


Ile His Trp Tyr Gln Gln Arg Thr Asn Gly Ser Pro Arg Leu Leu Ile 
        35                  40                  45              


Lys Tyr Ala Ser Glu Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Ile Ile Asn Ser Val Glu Ser 
65                  70                  75                  80  


Glu Asp Ile Ala Asp Tyr Tyr Cys Gln Gln Ser Asn Ser Trp Pro Thr 
                85                  90                  95      


Phe Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105             


<210>  37
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH sequence - 6G9

<400> 37

Gln Val Gln Leu His Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met Gln Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asp Pro Ser Asp Ser Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Thr Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Pro Leu Asp Arg Ser Ala Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120 


<210>  38
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL sequence - 6G9

<400> 38

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Phe Ser 
            20                  25                  30          


Gly Asn Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Asp Ser Gly Ile Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Val Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asn 
65                  70                  75                  80  


Pro Val Glu Ala Asp Asp Val Ala Thr Tyr Tyr Cys Gln Gln Ser Asn 
                85                  90                  95      


Glu Asp Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Glu 
            100                 105                 110     


<210>  39
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH sequence - 2B11

<400> 39

Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Leu Thr Cys Ser Val Thr Gly Tyr Ser Ile Thr Ser Gly 
            20                  25                  30          


Tyr Tyr Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp 
        35                  40                  45              


Met Gly His Ile Ala Asn Asp Gly Ser Asn Tyr Tyr Asn Pro Phe Leu 
    50                  55                  60                  


Lys His Arg Val Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe 
65                  70                  75                  80  


Leu Lys Leu Asn Ser Val Thr Ile Gln Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Ser Tyr Phe Asp Tyr Val Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser Ser 
        115                 


<210>  40
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL sequence - 2B11

<400> 40

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Asn Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Thr Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Phe 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  41
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 41

Gly Phe Ser Leu Asn Asp Tyr Gly Val His 
1               5                   10  


<210>  42
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 42

Gly Phe Ser Leu Asn Asp Tyr Gly 
1               5               


<210>  43
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 43

Asp Tyr Gly Val His 
1               5   


<210>  44
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 44

Gly Phe Ser Leu Asn Asp Tyr 
1               5           


<210>  45
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 45

Asn Asp Tyr Gly Val His 
1               5       


<210>  46
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 46

Gly Tyr Thr Phe Thr Asp Tyr Gly Val Ile 
1               5                   10  


<210>  47
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 47

Gly Tyr Thr Phe Thr Asp Tyr Gly 
1               5               


<210>  48
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 48

Asp Tyr Gly Val Ile 
1               5   


<210>  49
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 49

Gly Tyr Thr Phe Thr Asp Tyr 
1               5           


<210>  50
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 50

Thr Asp Tyr Gly Val Ile 
1               5       


<210>  51
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 51

Gly Tyr Pro Phe Thr Ile Tyr Gly Met Asn 
1               5                   10  


<210>  52
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 52

Gly Tyr Pro Phe Thr Ile Tyr Gly 
1               5               


<210>  53
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 53

Ile Tyr Gly Met Asn 
1               5   


<210>  54
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 54

Gly Tyr Pro Phe Thr Ile Tyr 
1               5           


<210>  55
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 55

Thr Ile Tyr Gly Met Asn 
1               5       


<210>  56
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 56

Gly Tyr Thr Phe Thr Asp Tyr Tyr Ile Asn 
1               5                   10  


<210>  57
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 57

Gly Tyr Thr Phe Thr Asp Tyr Tyr 
1               5               


<210>  58
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 58

Asp Tyr Tyr Ile Asn 
1               5   


<210>  59
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 59

Thr Asp Tyr Tyr Ile Asn 
1               5       


<210>  60
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 60

Gly Tyr Thr Phe Thr Asp Tyr Trp Ile Glu 
1               5                   10  


<210>  61
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 61

Gly Tyr Thr Phe Thr Asp Tyr Trp 
1               5               


<210>  62
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 62

Asp Tyr Trp Ile Glu 
1               5   


<210>  63
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 63

Thr Asp Tyr Trp Ile Glu 
1               5       


<210>  64
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 64

Gly Phe Ser Leu Ser Arg Tyr Ser Val His 
1               5                   10  


<210>  65
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 65

Gly Phe Ser Leu Ser Arg Tyr Ser 
1               5               


<210>  66
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 66

Arg Tyr Ser Val His 
1               5   


<210>  67
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 67

Gly Phe Ser Leu Ser Arg Tyr 
1               5           


<210>  68
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 68

Ser Arg Tyr Ser Val His 
1               5       


<210>  69
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 69

Gly Tyr Thr Phe Thr Asp Tyr Trp Ile His 
1               5                   10  


<210>  70
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 70

Asp Tyr Trp Ile His 
1               5   


<210>  71
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 71

Thr Asp Tyr Trp Ile His 
1               5       


<210>  72
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 72

Gly Tyr Thr Phe Thr Ser Tyr Trp Val Asn 
1               5                   10  


<210>  73
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 73

Gly Tyr Thr Phe Thr Ser Tyr Trp 
1               5               


<210>  74
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 74

Ser Tyr Trp Val Asn 
1               5   


<210>  75
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 75

Gly Tyr Thr Phe Thr Ser Tyr 
1               5           


<210>  76
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 76

Thr Ser Tyr Trp Val Asn 
1               5       


<210>  77
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 77

Gly Tyr Thr Phe Thr Thr Tyr Gly Met Ser 
1               5                   10  


<210>  78
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 78

Gly Tyr Thr Phe Thr Thr Tyr Gly 
1               5               


<210>  79
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 79

Thr Tyr Gly Met Ser 
1               5   


<210>  80
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 80

Gly Tyr Thr Phe Thr Thr Tyr 
1               5           


<210>  81
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 81

Thr Thr Tyr Gly Met Ser 
1               5       


<210>  82
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 82

Gly Tyr Thr Phe Thr Asp Tyr Ser Met His 
1               5                   10  


<210>  83
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 83

Gly Tyr Thr Phe Thr Asp Tyr Ser 
1               5               


<210>  84
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 84

Asp Tyr Ser Met His 
1               5   


<210>  85
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 85

Thr Asp Tyr Ser Met His 
1               5       


<210>  86
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 86

Gly Tyr Ser Phe Thr Ser Tyr Asn Ile Asp 
1               5                   10  


<210>  87
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 87

Gly Tyr Ser Phe Thr Ser Tyr Asn 
1               5               


<210>  88
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 88

Ser Tyr Asn Ile Asp 
1               5   


<210>  89
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 89

Gly Tyr Ser Phe Thr Ser Tyr 
1               5           


<210>  90
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 90

Thr Ser Tyr Asn Ile Asp 
1               5       


<210>  91
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 91

Gly Tyr Thr Phe Thr Ser Tyr Asn Ile Asn 
1               5                   10  


<210>  92
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 92

Gly Tyr Thr Phe Thr Ser Tyr Asn 
1               5               


<210>  93
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 93

Ser Tyr Asn Ile Asn 
1               5   


<210>  94
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 94

Thr Ser Tyr Asn Ile Asn 
1               5       


<210>  95
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 95

Gly Phe Thr Phe Thr Gly Tyr Asn Ile Asn 
1               5                   10  


<210>  96
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 96

Gly Phe Thr Phe Thr Gly Tyr Asn 
1               5               


<210>  97
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 97

Gly Tyr Asn Ile Asn 
1               5   


<210>  98
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 98

Gly Phe Thr Phe Thr Gly Tyr 
1               5           


<210>  99
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 99

Thr Gly Tyr Asn Ile Asn 
1               5       


<210>  100
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 100

Gly Tyr Ala Phe Thr Ser Tyr Trp Met Asn 
1               5                   10  


<210>  101
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 101

Gly Tyr Ala Phe Thr Ser Tyr Trp 
1               5               


<210>  102
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 102

Ser Tyr Trp Met Asn 
1               5   


<210>  103
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 103

Gly Tyr Ala Phe Thr Ser Tyr 
1               5           


<210>  104
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 104

Thr Ser Tyr Trp Met Asn 
1               5       


<210>  105
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 105

Gly Phe Thr Phe Ser Asp Tyr Phe Met Phe 
1               5                   10  


<210>  106
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 106

Gly Phe Thr Phe Ser Asp Tyr Phe 
1               5               


<210>  107
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 107

Asp Tyr Phe Met Phe 
1               5   


<210>  108
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 108

Gly Phe Thr Phe Ser Asp Tyr 
1               5           


<210>  109
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 109

Ser Asp Tyr Phe Met Phe 
1               5       


<210>  110
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 110

Gly Tyr Thr Phe Ala Asn Tyr Gly Leu Thr 
1               5                   10  


<210>  111
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 111

Gly Tyr Thr Phe Ala Asn Tyr Gly 
1               5               


<210>  112
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 112

Asn Tyr Gly Leu Thr 
1               5   


<210>  113
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 113

Gly Tyr Thr Phe Ala Asn Tyr 
1               5           


<210>  114
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 114

Ala Asn Tyr Gly Leu Thr 
1               5       


<210>  115
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 115

Gly Phe Thr Phe Ser Thr Tyr Ala Met Ser 
1               5                   10  


<210>  116
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 116

Gly Phe Thr Phe Ser Thr Tyr Ala 
1               5               


<210>  117
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 117

Thr Tyr Ala Met Ser 
1               5   


<210>  118
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 118

Gly Phe Thr Phe Ser Thr Tyr 
1               5           


<210>  119
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 119

Ser Thr Tyr Ala Met Ser 
1               5       


<210>  120
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 120

Gly Tyr Thr Phe Thr Thr Tyr Trp Met His 
1               5                   10  


<210>  121
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 121

Gly Tyr Thr Phe Thr Thr Tyr Trp 
1               5               


<210>  122
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 122

Thr Tyr Trp Met His 
1               5   


<210>  123
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 123

Thr Thr Tyr Trp Met His 
1               5       


<210>  124
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence
       peptide

<400> 124
Gly Tyr Thr Phe Thr Ser Tyr Trp Met Gln 
1               5                   10  


<210>  125
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 125

Ser Tyr Trp Met Gln 
1               5   


<210>  126
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 126

Thr Ser Tyr Trp Met Gln 
1               5       


<210>  127
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 127

Gly Tyr Ser Ile Thr Ser Gly Tyr Tyr Trp Asn 
1               5                   10      


<210>  128
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 128

Gly Tyr Ser Ile Thr Ser Gly Tyr Tyr 
1               5                   


<210>  129
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 129

Ser Gly Tyr Tyr Trp Asn 
1               5       


<210>  130
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 130

Gly Tyr Ser Ile Thr Ser Gly Tyr 
1               5               


<210>  131
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 131

Thr Ser Gly Tyr Tyr Trp Asn 
1               5           


<210>  132
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 132

Val Ile Trp Ser Gly Gly Arg Thr Asp Tyr Asn Ala Ala Phe Ile Ser 
1               5                   10                  15      


<210>  133
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 133

Ile Trp Ser Gly Gly Arg Thr 
1               5           


<210>  134
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 134

Ser Gly Gly 
1           


<210>  135
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 135

Trp Leu Gly Val Ile Trp Ser Gly Gly Arg Thr Asp 
1               5                   10          


<210>  136
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 136

Val Ile Trp Ser Gly Gly Arg Thr Asp 
1               5                   


<210>  137
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 137

Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Asp Leu Lys 
1               5                   10                  15      


Gly 
    


<210>  138
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 138

Ile Asn Thr Tyr Thr Gly Glu Pro 
1               5               


<210>  139
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 139

Thr Tyr Thr Gly 
1               


<210>  140
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 140

Trp Met Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr 
1               5                   10              


<210>  141
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 141

Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr 
1               5                   10  


<210>  142
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 142

Trp Ile Asn Thr Tyr Ser Gly Val Pro Thr Tyr Ala Asp Asp Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  143
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 143

Ile Asn Thr Tyr Ser Gly Val Pro 
1               5               


<210>  144
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 144

Thr Tyr Ser Gly 
1               


<210>  145
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 145

Trp Met Gly Trp Ile Asn Thr Tyr Ser Gly Val Pro Thr 
1               5                   10              


<210>  146
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 146

Trp Ile Asn Thr Tyr Ser Gly Val Pro Thr 
1               5                   10  


<210>  147
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 147

Arg Ile Tyr Pro Gly Asn Gly Asn Thr Tyr His Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  148
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 148

Ile Tyr Pro Gly Asn Gly Asn Thr 
1               5               


<210>  149
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 149

Pro Gly Asn Gly 
1               


<210>  150
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 150

Trp Ile Ala Arg Ile Tyr Pro Gly Asn Gly Asn Thr Tyr 
1               5                   10              


<210>  151
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 151

Arg Ile Tyr Pro Gly Asn Gly Asn Thr Tyr 
1               5                   10  


<210>  152
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 152

Glu Ile Leu Leu Gly Ser Asp Ser Ile His Phe Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  153
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 153

Ile Leu Leu Gly Ser Asp Ser Ile 
1               5               


<210>  154
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 154

Leu Gly Ser Asp 
1               


<210>  155
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 155

Trp Ile Gly Glu Ile Leu Leu Gly Ser Asp Ser Ile His 
1               5                   10              


<210>  156
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 156

Glu Ile Leu Leu Gly Ser Asp Ser Ile His 
1               5                   10  


<210>  157
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 157

Met Ile Trp Gly Phe Gly Ser Thr Asp Tyr Asn Ser Ala Leu Lys Ser 
1               5                   10                  15      


<210>  158
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 158

Gly Phe Gly 
1           


<210>  159
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 159

Trp Leu Gly Met Ile Trp Gly Phe Gly Ser Thr Asp 
1               5                   10          


<210>  160
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 160

Met Ile Trp Gly Phe Gly Ser Thr Asp 
1               5                   


<210>  161
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 161

Tyr Ile Asn Pro Asn Ser Asn Tyr Ala Glu Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Val 
    


<210>  162
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 162

Ile Asn Pro Asn Ser Asn Tyr Ala 
1               5               


<210>  163
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 163

Pro Asn Ser Asn 
1               


<210>  164
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 164

Trp Ile Gly Tyr Ile Asn Pro Asn Ser Asn Tyr Ala Glu 
1               5                   10              


<210>  165
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 165

Tyr Ile Asn Pro Asn Ser Asn Tyr Ala Glu 
1               5                   10  


<210>  166
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 166

Arg Ile Tyr Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  167
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 167

Ile Tyr Pro Gly Asp Gly Asp Thr 
1               5               


<210>  168
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 168

Pro Gly Asp Gly 
1               


<210>  169
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 169

Trp Ile Gly Arg Ile Tyr Pro Gly Asp Gly Asp Thr Asn 
1               5                   10              


<210>  170
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 170

Arg Ile Tyr Pro Gly Asp Gly Asp Thr Asn 
1               5                   10  


<210>  171
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 171

Trp Ile Asn Thr Tyr Ser Gly Val Pro Thr Phe Val Asp Asp Phe Arg 
1               5                   10                  15      


Gly 
    


<210>  172
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 172

Trp Ile Asn Thr Glu Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  173
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 173

Ile Asn Thr Glu Thr Gly Glu Pro 
1               5               


<210>  174
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 174

Thr Glu Thr Gly 
1               


<210>  175
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 175

Trp Met Gly Trp Ile Asn Thr Glu Thr Gly Glu Pro Thr 
1               5                   10              


<210>  176
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 176

Trp Ile Asn Thr Glu Thr Gly Glu Pro Thr 
1               5                   10  


<210>  177
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 177

Trp Ile Phe Pro Gly Asp Gly Ser Thr 
1               5                   


<210>  178
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 178

Ile Phe Pro Gly Asp Gly Ser Thr 
1               5               


<210>  179
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 179

Trp Ile Phe Pro Gly Asp Gly Ser Thr Lys Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  180
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 180

Trp Ile Gly Trp Ile Phe Pro Gly Asp Gly Ser Thr Lys 
1               5                   10              


<210>  181
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 181

Trp Ile Phe Pro Gly Asp Gly Ser Thr Lys 
1               5                   10  


<210>  182
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 182

Trp Ile Phe Pro Gly Asp Asp Ser Ile Lys Tyr Asn Glu Asn Phe Arg 
1               5                   10                  15      


Gly 
    


<210>  183
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 183

Ile Phe Pro Gly Asp Asp Ser Ile 
1               5               


<210>  184
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 184

Pro Gly Asp Asp 
1               


<210>  185
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 185

Trp Ile Gly Trp Ile Phe Pro Gly Asp Asp Ser Ile Lys 
1               5                   10              


<210>  186
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 186

Trp Ile Phe Pro Gly Asp Asp Ser Ile Lys 
1               5                   10  


<210>  187
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 187

Trp Ile Phe Pro Gly Asp Asp Asn Ala Lys Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  188
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 188

Ile Phe Pro Gly Asp Asp Asn Ala 
1               5               


<210>  189
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 189

Trp Ile Gly Trp Ile Phe Pro Gly Asp Asp Asn Ala Lys 
1               5                   10              


<210>  190
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 190

Trp Ile Phe Pro Gly Asp Asp Asn Ala Lys 
1               5                   10  


<210>  191
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 191

Tyr Ile Ser Asn Asp Gly Asp Ser Thr Tyr Tyr Pro Asp Thr Val Gln 
1               5                   10                  15      


Gly 
    


<210>  192
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 192

Ile Ser Asn Asp Gly Asp Ser Thr 
1               5               


<210>  193
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 193

Asn Asp Gly Asp 
1               


<210>  194
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 194

Trp Val Ala Tyr Ile Ser Asn Asp Gly Asp Ser Thr Tyr 
1               5                   10              


<210>  195
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 195

Tyr Ile Ser Asn Asp Gly Asp Ser Thr Tyr 
1               5                   10  


<210>  196
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 196

Glu Ile Tyr Pro Gly Ser Gly His Thr His Tyr Asn Glu Asp Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  197
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 197

Ile Tyr Pro Gly Ser Gly His Thr 
1               5               


<210>  198
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 198

Pro Gly Ser Gly 
1               


<210>  199
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 199

Trp Ile Gly Glu Ile Tyr Pro Gly Ser Gly His Thr His 
1               5                   10              


<210>  200
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 200

Glu Ile Tyr Pro Gly Ser Gly His Thr His 
1               5                   10  


<210>  201
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 201

Ser Ile Thr Ser Gly Gly Thr Thr Tyr Tyr Thr Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  202
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 202

Ile Thr Ser Gly Gly Thr Thr 
1               5           


<210>  203
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 203

Trp Val Ala Ser Ile Thr Ser Gly Gly Thr Thr Tyr 
1               5                   10          


<210>  204
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 204

Ser Ile Thr Ser Gly Gly Thr Thr Tyr 
1               5                   


<210>  205
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 205

Met Ile His Pro Asn Ser Gly Ser Ser Asn Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Asn 
    


<210>  206
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 206

Ile His Pro Asn Ser Gly Ser Ser 
1               5               


<210>  207
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 207

Pro Asn Ser Gly 
1               


<210>  208
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 208

Trp Ile Gly Met Ile His Pro Asn Ser Gly Ser Ser Asn 
1               5                   10              


<210>  209
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 209

Met Ile His Pro Asn Ser Gly Ser Ser Asn 
1               5                   10  


<210>  210
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 210

Glu Ile Asp Pro Ser Asp Ser Tyr Thr Asn Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  211
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 211

Ile Asp Pro Ser Asp Ser Tyr Thr 
1               5               


<210>  212
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 212

Pro Ser Asp Ser 
1               


<210>  213
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 213

Trp Ile Gly Glu Ile Asp Pro Ser Asp Ser Tyr Thr Asn 
1               5                   10              


<210>  214
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 214

Glu Ile Asp Pro Ser Asp Ser Tyr Thr Asn 
1               5                   10  


<210>  215
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 215

His Ile Ala Asn Asp Gly Ser Asn Tyr Tyr Asn Pro Phe Leu Lys His 
1               5                   10                  15      


<210>  216
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 216

Ile Ala Asn Asp Gly Ser Asn 
1               5           


<210>  217
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 217

Asn Asp Gly 
1           


<210>  218
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 218

Trp Met Gly His Ile Ala Asn Asp Gly Ser Asn Tyr 
1               5                   10          


<210>  219
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 219

His Ile Ala Asn Asp Gly Ser Asn Tyr 
1               5                   


<210>  220
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 220

Ile Trp Gly Phe Gly Ser Thr 
1               5           


<210>  221
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 221

Trp Ala Leu Tyr Phe Leu Tyr Gly Gly Ser Met Asp Tyr 
1               5                   10              


<210>  222
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 222

Ala Arg Trp Ala Leu Tyr Phe Leu Tyr Gly Gly Ser Met Asp Tyr 
1               5                   10                  15  


<210>  223
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 223

Ala Leu Tyr Phe Leu Tyr Gly Gly Ser Met Asp 
1               5                   10      


<210>  224
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 224

Ala Arg Trp Ala Leu Tyr Phe Leu Tyr Gly Gly Ser Met Asp 
1               5                   10                  


<210>  225
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 225

Arg Tyr Gly Pro Glu Asp Ile Asp Tyr 
1               5                   


<210>  226
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 226

Ala Arg Arg Tyr Gly Pro Glu Asp Ile Asp Tyr 
1               5                   10      


<210>  227
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 227

Tyr Gly Pro Glu Asp Ile Asp 
1               5           


<210>  228
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 228

Ala Arg Arg Tyr Gly Pro Glu Asp Ile Asp 
1               5                   10  


<210>  229
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 229

Ala Thr Gly Asn Tyr 
1               5   


<210>  230
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 230

Ala Ser Ala Thr Gly Asn Tyr 
1               5           


<210>  231
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 231

Thr Gly Asn 
1           


<210>  232
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 232

Ala Ser Ala Thr Gly Asn 
1               5       


<210>  233
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 233

Glu Gly Leu Tyr Tyr Asp Tyr Asp Arg Tyr Phe Asp Tyr 
1               5                   10              


<210>  234
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 234

Ala Arg Glu Gly Leu Tyr Tyr Asp Tyr Asp Arg Tyr Phe Asp Tyr 
1               5                   10                  15  


<210>  235
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 235

Gly Leu Tyr Tyr Asp Tyr Asp Arg Tyr Phe Asp 
1               5                   10      


<210>  236
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 236

Ala Arg Glu Gly Leu Tyr Tyr Asp Tyr Asp Arg Tyr Phe Asp 
1               5                   10                  


<210>  237
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 237

Gln Asp Trp Asn Trp Tyr Phe Asp Val 
1               5                   


<210>  238
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 238

Val Arg Gln Asp Trp Asn Trp Tyr Phe Asp Val 
1               5                   10      


<210>  239
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 239

Asp Trp Asn Trp Tyr Phe Asp 
1               5           


<210>  240
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 240

Val Arg Gln Asp Trp Asn Trp Tyr Phe Asp 
1               5                   10  


<210>  241
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 241

Ile His Thr Thr Ala Gly Ser Tyr 
1               5               


<210>  242
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 242

Ala Arg Ile His Thr Thr Ala Gly Ser Tyr 
1               5                   10  


<210>  243
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence
 
<400> 243

His Thr Thr Ala Gly Ser 
1               5       


<210>  244
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 244

Ala Arg Ile His Thr Thr Ala Gly Ser 
1               5                   


<210>  245
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 245

Phe Asp Trp Asn Trp Tyr Phe His Val 
1               5                   


<210>  246
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 246

Ala Arg Phe Asp Trp Asn Trp Tyr Phe His Val 
1               5                   10      


<210>  247
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 247

Asp Trp Asn Trp Tyr Phe His 
1               5           


<210>  248
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 248

Ala Arg Phe Asp Trp Asn Trp Tyr Phe His 
1               5                   10  


<210>  249
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 249

Ala Tyr Leu Leu Arg Leu Arg Arg Thr Gly Tyr Tyr Ala Met Asp Tyr 
1               5                   10                  15      


<210>  250
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 250

Ala Arg Ala Tyr Leu Leu Arg Leu Arg Arg Thr Gly Tyr Tyr Ala Met 
1               5                   10                  15      


Asp Tyr 
        


<210>  251
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 251

Tyr Leu Leu Arg Leu Arg Arg Thr Gly Tyr Tyr Ala Met Asp 
1               5                   10                  


<210>  252
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 252

Ala Arg Ala Tyr Leu Leu Arg Leu Arg Arg Thr Gly Tyr Tyr Ala Met 
1               5                   10                  15      


Asp 
    


<210>  253
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 253

Arg Ser Ser Tyr Tyr Pro Tyr Trp Tyr Phe Asp Val 
1               5                   10          


<210>  254
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 254

Ala Arg Arg Ser Ser Tyr Tyr Pro Tyr Trp Tyr Phe Asp Val 
1               5                   10                  


<210>  255
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 255

Ser Ser Tyr Tyr Pro Tyr Trp Tyr Phe Asp 
1               5                   10  


<210>  256
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 256

Ala Arg Arg Ser Ser Tyr Tyr Pro Tyr Trp Tyr Phe Asp 
1               5                   10              


<210>  257
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 257

Gly Thr Leu Asn Tyr 
1               5   


<210>  258
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 258

Val Lys Gly Thr Leu Asn Tyr 
1               5           


<210>  259
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 259

Thr Leu Asn 
1           


<210>  260
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 260

Val Lys Gly Thr Leu Asn 
1               5       


<210>  261
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 261

Ser Gly Ile Tyr Tyr Gly Ser His Phe Val Tyr 
1               5                   10      


<210>  262
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 262

Ala Arg Ser Gly Ile Tyr Tyr Gly Ser His Phe Val Tyr 
1               5                   10              


<210>  263
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 263

Gly Ile Tyr Tyr Gly Ser His Phe Val 
1               5                   


<210>  264
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 264

Ala Arg Ser Gly Ile Tyr Tyr Gly Ser His Phe Val 
1               5                   10          


<210>  265
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 265

Ser Gly Ile Phe Tyr Gly Asn Asn Phe Ala Tyr 
1               5                   10      


<210>  266
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 266

Ala Arg Ser Gly Ile Phe Tyr Gly Asn Asn Phe Ala Tyr 
1               5                   10              


<210>  267
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 267

Gly Ile Phe Tyr Gly Asn Asn Phe Ala 
1               5                   


<210>  268
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 268

Ala Arg Ser Gly Ile Phe Tyr Gly Asn Asn Phe Ala 
1               5                   10          


<210>  269
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 269

Thr Pro Val Leu Ser Asn Tyr Phe Asp Tyr 
1               5                   10  


<210>  270
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 270

Ala Arg Thr Pro Val Leu Ser Asn Tyr Phe Asp Tyr 
1               5                   10          


<210>  271
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 271

Pro Val Leu Ser Asn Tyr Phe Asp 
1               5               


<210>  272
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 272

Ala Arg Thr Pro Val Leu Ser Asn Tyr Phe Asp 
1               5                   10      


<210>  273
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 273

Gln Gly Ala Gln Ala Thr Leu Asp Tyr 
1               5                   


<210>  274
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 274

Thr Arg Gln Gly Ala Gln Ala Thr Leu Asp Tyr 
1               5                   10      


<210>  275
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 275

Gly Ala Gln Ala Thr Leu Asp 
1               5           


<210>  276
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 276

Thr Arg Gln Gly Ala Gln Ala Thr Leu Asp 
1               5                   10  


<210>  277
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 277

Arg Ile Gln Leu Leu Leu Pro Val Gly Gly Phe Val Tyr 
1               5                   10              


<210>  278
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 278

Ala Arg Arg Ile Gln Leu Leu Leu Pro Val Gly Gly Phe Val Tyr 
1               5                   10                  15  


<210>  279
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 279

Ile Gln Leu Leu Leu Pro Val Gly Gly Phe Val 
1               5                   10      


<210>  280
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 280

Ala Arg Arg Ile Gln Leu Leu Leu Pro Val Gly Gly Phe Val 
1               5                   10                  


<210>  281
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 281

Asp Gly Asn Phe Tyr Tyr Tyr Gly Met Asp Tyr 
1               5                   10      


<210>  282
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 282

Ala Arg Asp Gly Asn Phe Tyr Tyr Tyr Gly Met Asp Tyr 
1               5                   10              


<210>  283
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 283

Gly Asn Phe Tyr Tyr Tyr Gly Met Asp 
1               5                   


<210>  284
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 284

Ala Arg Asp Gly Asn Phe Tyr Tyr Tyr Gly Met Asp 
1               5                   10          


<210>  285
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 285

Ser Asp Tyr Gly Phe Ile Pro Tyr Phe Asp Tyr 
1               5                   10      


<210>  286
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 286

Ala Arg Ser Asp Tyr Gly Phe Ile Pro Tyr Phe Asp Tyr 
1               5                   10              


<210>  287
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 287

Asp Tyr Gly Phe Ile Pro Tyr Phe Asp 
1               5                   


<210>  288
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 288

Ala Arg Ser Asp Tyr Gly Phe Ile Pro Tyr Phe Asp 
1               5                   10          


<210>  289
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 289

Pro Leu Asp Arg Ser Ala Tyr Tyr Phe Asp Tyr 
1               5                   10      


<210>  290
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 290

Ala Arg Pro Leu Asp Arg Ser Ala Tyr Tyr Phe Asp Tyr 
1               5                   10              


<210>  291
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 291

Leu Asp Arg Ser Ala Tyr Tyr Phe Asp 
1               5                   


<210>  292
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 292

Ala Arg Pro Leu Asp Arg Ser Ala Tyr Tyr Phe Asp 
1               5                   10          


<210>  293
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 293

Gly Gly Ser Tyr Phe Asp Tyr Val Asp Tyr 
1               5                   10  


<210>  294
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 294

Ala Arg Gly Gly Ser Tyr Phe Asp Tyr Val Asp Tyr 
1               5                   10          


<210>  295
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 295

Gly Ser Tyr Phe Asp Tyr Val Asp 
1               5               


<210>  296
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 296

Ala Arg Gly Gly Ser Tyr Phe Asp Tyr Val Asp 
1               5                   10      


<210>  297
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 297

Arg Ser Ser Gln Ser Leu Val His Ser Ser Gly Ile Thr Tyr Leu His 
1               5                   10                  15      


<210>  298
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 298

Gln Ser Leu Val His Ser Ser Gly Ile Thr Tyr 
1               5                   10      


<210>  299
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 299

Ser Gln Ser Leu Val His Ser Ser Gly Ile Thr Tyr 
1               5                   10          


<210>  300
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 300

Val His Ser Ser Gly Ile Thr Tyr Leu His Trp Tyr 
1               5                   10          


<210>  301
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 301

Arg Ala Ser Glu Ser Val Asp Asn Tyr Gly Ile Ser Phe Met Ser 
1               5                   10                  15  


<210>  302
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 302

Glu Ser Val Asp Asn Tyr Gly Ile Ser Phe 
1               5                   10  


<210>  303
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 303

Ser Glu Ser Val Asp Asn Tyr Gly Ile Ser Phe 
1               5                   10      


<210>  304
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 304

Asp Asn Tyr Gly Ile Ser Phe Met Ser Trp Phe 
1               5                   10      


<210>  305
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 305

Arg Ala Ser Gln Asp Ile Gly Ser Ser Leu Asn 
1               5                   10      


<210>  306
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 306

Gln Asp Ile Gly Ser Ser 
1               5       


<210>  307
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 307

Ser Gln Asp Ile Gly Ser Ser 
1               5           


<210>  308
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 308

Gly Ser Ser Leu Asn Trp Leu 
1               5           


<210>  309
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 309

Arg Ala Ser Glu Ser Val Asp Thr Tyr Gly Asn Ser Phe Met His 
1               5                   10                  15  


<210>  310
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 310

Glu Ser Val Asp Thr Tyr Gly Asn Ser Phe 
1               5                   10  


<210>  311
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 311

Ser Glu Ser Val Asp Thr Tyr Gly Asn Ser Phe 
1               5                   10      


<210>  312
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 312

Asp Thr Tyr Gly Asn Ser Phe Met His Trp Tyr 
1               5                   10      


<210>  313
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 313

Lys Ser Ser Gln Ser Leu Leu Asp Phe Asp Gly Lys Thr Tyr Leu Asn 
1               5                   10                  15      


<210>  314
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 314

Gln Ser Leu Leu Asp Phe Asp Gly Lys Thr Tyr 
1               5                   10      


<210>  315
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 315

Ser Gln Ser Leu Leu Asp Phe Asp Gly Lys Thr Tyr 
1               5                   10          


<210>  316
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 316

Leu Asp Phe Asp Gly Lys Thr Tyr Leu Asn Trp Tyr 
1               5                   10          


<210>  317
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 317

Lys Ala Ser Gln Asn Val Gly Thr Asn Val Ala 
1               5                   10      


<210>  318
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 318

Gln Asn Val Gly Thr Asn 
1               5       


<210>  319
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 319

Ser Gln Asn Val Gly Thr Asn 
1               5           


<210>  320
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 320

Gly Thr Asn Val Ala Trp Tyr 
1               5           


<210>  321
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 321

Lys Ser Ser Gln Ser Leu Ser Asp Ser Asp Gly Lys Thr Tyr Leu Asn 
1               5                   10                  15      


<210>  322
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 322

Gln Ser Leu Ser Asp Ser Asp Gly Lys Thr Tyr 
1               5                   10      


<210>  323
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 323

Ser Gln Ser Leu Ser Asp Ser Asp Gly Lys Thr Tyr 
1               5                   10          


<210>  324
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 324

Ser Asp Ser Asp Gly Lys Thr Tyr Leu Asn Trp Leu 
1               5                   10          


<210>  325
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 325

Lys Ser Thr Lys Ser Leu Leu Asn Ser Asp Glu Phe Thr Tyr Leu Asp 
1               5                   10                  15      


<210>  326
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 326

Lys Ser Leu Leu Asn Ser Asp Glu Phe Thr Tyr 
1               5                   10      


<210>  327
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 327

Thr Lys Ser Leu Leu Asn Ser Asp Glu Phe Thr Tyr 
1               5                   10          


<210>  328
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 328

Leu Asn Ser Asp Glu Phe Thr Tyr Leu Asp Trp Tyr 
1               5                   10          


<210>  329
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 329

Arg Pro Ser Glu Asn Ile Tyr Ser Tyr Leu Thr 
1               5                   10      


<210>  330
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 330

Glu Asn Ile Tyr Ser Tyr 
1               5       


<210>  331
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 331

Ser Glu Asn Ile Tyr Ser Tyr 
1               5           


<210>  332
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 332

Tyr Ser Tyr Leu Thr Trp Phe 
1               5           


<210>  333
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 333

Lys Ala Ser Gln Asp Ile Lys Ser Tyr Leu Asn 
1               5                   10      


<210>  334
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 334

Gln Asp Ile Lys Ser Tyr 
1               5       


<210>  335
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 335

Ser Gln Asp Ile Lys Ser Tyr 
1               5           


<210>  336
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 336

Lys Ser Tyr Leu Asn Trp Phe 
1               5           


<210>  337
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 337

Arg Ser Ser Gln Ser Leu Leu Asp Ser Asp Gly Lys Thr Tyr Leu Asn 
1               5                   10                  15      


<210>  338
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 338

Gln Ser Leu Leu Asp Ser Asp Gly Lys Thr Tyr 
1               5                   10      


<210>  339
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 339

Ser Gln Ser Leu Leu Asp Ser Asp Gly Lys Thr Tyr 
1               5                   10          


<210>  340
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 340

Leu Asp Ser Asp Gly Lys Thr Tyr Leu Asn Trp Leu 
1               5                   10          


<210>  341
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 341

Lys Ser Ser Gln Ser Leu Leu Asp Gly Asp Gly Glu Thr Tyr Leu Ser 
1               5                   10                  15      


<210>  342
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 342

Gln Ser Leu Leu Asp Gly Asp Gly Glu Thr Tyr 
1               5                   10      


<210>  343
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 343

Ser Gln Ser Leu Leu Asp Gly Asp Gly Glu Thr Tyr 
1               5                   10          


<210>  344
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 344

Leu Asp Gly Asp Gly Glu Thr Tyr Leu Ser Trp Leu 
1               5                   10          


<210>  345
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 345

Lys Ala Ser Gln Asp Ile Ser Lys Tyr Ile Ser 
1               5                   10      


<210>  346
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 346

Gln Asp Ile Ser Lys Tyr 
1               5       


<210>  347
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 347

Ser Gln Asp Ile Ser Lys Tyr 
1               5           


<210>  348
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 348

Ser Lys Tyr Ile Ser Trp Tyr 
1               5           


<210>  349
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 349

Ser Ala Ser Ser Ser Val Phe Tyr Met His 
1               5                   10  


<210>  350
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 350

Ser Ser Val Phe Tyr 
1               5   


<210>  351
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 351

Ser Ser Ser Val Phe Tyr 
1               5       


<210>  352
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 352

Phe Tyr Met His Trp Tyr 
1               5       


<210>  353
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 353

Arg Ala Ser Gln Ser Ile Ser Asn Asn Leu His 
1               5                   10      


<210>  354
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 354

Gln Ser Ile Ser Asn Asn 
1               5       


<210>  355
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 355

Ser Gln Ser Ile Ser Asn Asn 
1               5           


<210>  356
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 356

Ser Asn Asn Leu His Trp Tyr 
1               5           


<210>  357
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 357

Lys Ala Ser Gln Asn Val Gly Thr Ala Val Ala 
1               5                   10      


<210>  358
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 358

Gln Asn Val Gly Thr Ala 
1               5       


<210>  359
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 359

Ser Gln Asn Val Gly Thr Ala 
1               5           


<210>  360
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 360

Gly Thr Ala Val Ala Trp Tyr 
1               5           


<210>  361
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 361

Arg Ala Ser Gln Ser Ile Gly Thr Ser Ile His 
1               5                   10      


<210>  362
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 362

Gln Ser Ile Gly Thr Ser 
1               5       


<210>  363
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 363

Ser Gln Ser Ile Gly Thr Ser 
1               5           


<210>  364
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 364

Gly Thr Ser Ile His Trp Tyr 
1               5           


<210>  365
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 365

Arg Ala Ser Glu Ser Val Asp Phe Ser Gly Asn Ser Phe Met His 
1               5                   10                  15  


<210>  366
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 366

Glu Ser Val Asp Phe Ser Gly Asn Ser Phe 
1               5                   10  


<210>  367
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 367

Ser Glu Ser Val Asp Phe Ser Gly Asn Ser Phe 
1               5                   10      


<210>  368
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 368

Asp Phe Ser Gly Asn Ser Phe Met His Trp Tyr 
1               5                   10      


<210>  369
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 369

Arg Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn 
1               5                   10      


<210>  370
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 370

Gln Asp Ile Ser Asn Tyr 
1               5       


<210>  371
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 371

Ser Gln Asp Ile Ser Asn Tyr 
1               5           


<210>  372
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 372

Ser Asn Tyr Leu Asn Trp Tyr 
1               5           


<210>  373
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 373

Lys Leu Ser Asn Arg Phe Ser 
1               5           


<210>  374
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 374

Lys Leu Ser 
1           


<210>  375
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 375

Leu Leu Ile Tyr Lys Leu Ser Asn Arg Phe 
1               5                   10  


<210>  376
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 376

Ala Ala Ser His Gln Gly Ser 
1               5           


<210>  377
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 377

Ala Ala Ser 
1           


<210>  378
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 378

Leu Leu Ile Tyr Ala Ala Ser His Gln Gly 
1               5                   10  


<210>  379
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 379

Ala Thr Ser Ser Leu Asp Ser 
1               5           


<210>  380
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 380

Ala Thr Ser 
1           


<210>  381
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 381

Arg Leu Ile Tyr Ala Thr Ser Ser Leu Asp 
1               5                   10  


<210>  382
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 382

Leu Ala Ser Asn Leu Glu Ser 
1               5           


<210>  383
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 383

Leu Ala Ser 
1           


<210>  384
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 384

Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu 
1               5                   10  


<210>  385
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 385

Leu Val Ser Lys Leu Asp Ser 
1               5           


<210>  386
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 386

Leu Val Ser 
1           


<210>  387
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 387

Arg Leu Phe Tyr Leu Val Ser Lys Leu Asp 
1               5                   10  


<210>  388
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 388

Ser Thr Ser Tyr Arg Tyr Ser 
1               5           


<210>  389
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 389

Ser Thr Ser 
1           


<210>  390
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 390

Ala Leu Val Tyr Ser Thr Ser Tyr Arg Tyr 
1               5                   10  


<210>  391
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 391

Leu Val Ser Arg Leu Gly Ser 
1               5           


<210>  392
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 392

Arg Leu Ile Tyr Leu Val Ser Arg Leu Gly 
1               5                   10  


<210>  393
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 393

Leu Val Ser Asn Arg Phe Ser 
1               5           


<210>  394
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 394

Leu Leu Ile Phe Leu Val Ser Asn Arg Phe 
1               5                   10  


<210>  395
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 395

Asn Ala Gln Thr Leu Ala Glu 
1               5           


<210>  396
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 396

Asn Ala Gln 
1           


<210>  397
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 397

Leu Leu Val Tyr Asn Ala Gln Thr Leu Ala 
1               5                   10  


<210>  398
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 398

Arg Thr Lys Arg Leu Val Asp 
1               5           


<210>  399
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 399

Arg Thr Lys 
1           


<210>  400
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 400

Thr Leu Ile Tyr Arg Thr Lys Arg Leu Val 
1               5                   10  


<210>  401
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 401

Leu Val Ser Lys Val Asp Ser 
1               5           


<210>  402
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 402

Arg Leu Ile Tyr Leu Val Ser Lys Val Asp 
1               5                   10  


<210>  403
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 403

Arg Leu Ile Tyr Leu Val Ser Lys Leu Asp 
1               5                   10  


<210>  404
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 404

Tyr Thr Ser Thr Leu Gln Pro 
1               5           


<210>  405
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 405

Tyr Thr Ser 
1           


<210>  406
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 406

Leu Leu Ile His Tyr Thr Ser Thr Leu Gln 
1               5                   10  


<210>  407
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 407

Leu Leu Ile Tyr Leu Val Ser Asn Arg Phe 
1               5                   10  


<210>  408
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 408

Ser Thr Ser Asn Leu Ala Ser 
1               5           


<210>  409
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 409

Leu Leu Ile Tyr Ser Thr Ser Asn Leu Ala 
1               5                   10  


<210>  410
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 410

Tyr Ala Ser Gln Ser Ile Ser 
1               5           


<210>  411
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 411

Tyr Ala Ser 
1           


<210>  412
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 412

Leu Leu Ile Lys Tyr Ala Ser Gln Ser Ile 
1               5                   10  


<210>  413
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 413

Ser Ala Ser Asn Arg Phe Thr 
1               5           


<210>  414
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 414

Ser Ala Ser 
1           


<210>  415
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 415

Ile Leu Ile Tyr Ser Ala Ser Asn Arg Phe 
1               5                   10  


<210>  416
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 416

Tyr Ala Ser Glu Ser Ile Ser 
1               5           


<210>  417
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 417

Leu Leu Ile Lys Tyr Ala Ser Glu Ser Ile 
1               5                   10  


<210>  418
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 418

Arg Ala Ser Asn Leu Asp Ser 
1               5           


<210>  419
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 419

Arg Ala Ser 
1           


<210>  420
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 420

Leu Leu Ile Tyr Arg Ala Ser Asn Leu Asp 
1               5                   10  


<210>  421
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 421

Tyr Thr Ser Arg Leu His Ser 
1               5           


<210>  422
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 422

Leu Leu Ile Tyr Tyr Thr Ser Arg Leu His 
1               5                   10  


<210>  423
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 423

Ser Gln Ser Thr His Val Pro Pro Trp Thr 
1               5                   10  


<210>  424
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 424

Ser Thr His Val Pro Pro Trp 
1               5           


<210>  425
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 425

Ser Gln Ser Thr His Val Pro Pro Trp 
1               5                   


<210>  426
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 426

Leu Gln Ser Lys Glu Val Pro Trp Thr 
1               5                   


<210>  427
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 427

Ser Lys Glu Val Pro Trp 
1               5       


<210>  428
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 428

Leu Gln Ser Lys Glu Val Pro Trp 
1               5               


<210>  429
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 429

Leu Gln Tyr Ala Ser Ser Pro Tyr Thr 
1               5                   


<210>  430
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 430

Tyr Ala Ser Ser Pro Tyr 
1               5       


<210>  431
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 431

Leu Gln Tyr Ala Ser Ser Pro Tyr 
1               5               


<210>  432
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 432

His Gln Asn Asn Glu Asp Pro Pro Ala 
1               5                   


<210>  433
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 433

Asn Asn Glu Asp Pro Pro 
1               5       


<210>  434
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 434

His Gln Asn Asn Glu Asp Pro Pro 
1               5               


<210>  435
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 435

Trp Gln Gly Thr His Phe Pro Arg Thr 
1               5                   


<210>  436
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 436

Gly Thr His Phe Pro Arg 
1               5       


<210>  437
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 437

Trp Gln Gly Thr His Phe Pro Arg 
1               5               


<210>  438
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 438

His Gln Tyr Asn Ser Tyr Pro Leu Thr 
1               5                   


<210>  439
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 439

Tyr Asn Ser Tyr Pro Leu 
1               5       


<210>  440
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 440

His Gln Tyr Asn Ser Tyr Pro Leu 
1               5               


<210>  441
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 441

Trp Gln Gly Thr His Phe Pro Gln Thr 
1               5                   


<210>  442
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 442

Gly Thr His Phe Pro Gln 
1               5       


<210>  443
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 443

Trp Gln Gly Thr His Phe Pro Gln 
1               5               


<210>  444
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 444

Phe Gln Ser Asn Tyr Leu Pro Tyr Thr 
1               5                   


<210>  445
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 445

Ser Asn Tyr Leu Pro Tyr 
1               5       


<210>  446
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 446

Phe Gln Ser Asn Tyr Leu Pro Tyr 
1               5               


<210>  447
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 447

Gln His Tyr Tyr Gly Tyr Pro Phe Thr 
1               5                   


<210>  448
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 448

Tyr Tyr Gly Tyr Pro Phe 
1               5       


<210>  449
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 449

Gln His Tyr Tyr Gly Tyr Pro Phe 
1               5               


<210>  450
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 450

Leu Gln Tyr Val Glu Phe Pro Leu Thr 
1               5                   


<210>  451
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 451

Tyr Val Glu Phe Pro Leu 
1               5       


<210>  452
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 452

Leu Gln Tyr Val Glu Phe Pro Leu 
1               5               


<210>  453
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 453

Trp Gln Gly Thr His Phe Pro Leu Thr 
1               5                   


<210>  454
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 454

Gly Thr His Phe Pro Leu 
1               5       


<210>  455
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 455

Trp Gln Gly Thr His Phe Pro Leu 
1               5               


<210>  456
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 456

Cys Gln Ser Thr His Phe Pro Leu Thr 
1               5                   


<210>  457
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 457

Ser Thr His Phe Pro Leu 
1               5       


<210>  458
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 458

Cys Gln Ser Thr His Phe Pro Leu 
1               5               


<210>  459
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 459

Leu Gln Tyr Asp Asn Leu Tyr Thr 
1               5               


<210>  460
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 460

Tyr Asp Asn Leu Tyr 
1               5   


<210>  461
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 461

Leu Gln Tyr Asp Asn Leu Tyr 
1               5           


<210>  462
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 462

His Gln Trp Ser Ser Thr 
1               5       


<210>  463
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 463

Trp Ser Ser 
1           


<210>  464
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 464

His Gln Trp Ser Ser 
1               5   


<210>  465
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 465

Gln Gln Ser Asn Ser Trp Pro His Thr 
1               5                   


<210>  466
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 466

Ser Asn Ser Trp Pro His 
1               5       


<210>  467
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 467

Gln Gln Ser Asn Ser Trp Pro His 
1               5               


<210>  468
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 468

Gln Gln Tyr Ser Ser Tyr Phe Thr 
1               5               


<210>  469
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 469

Tyr Ser Ser Tyr Phe 
1               5   


<210>  470
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 470

Gln Gln Tyr Ser Ser Tyr Phe 
1               5           


<210>  471
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 471

Gln Gln Ser Asn Ser Trp Pro Thr Phe Thr 
1               5                   10  


<210>  472
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 472

Ser Asn Ser Trp Pro Thr Phe 
1               5           


<210>  473
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 473

Gln Gln Ser Asn Ser Trp Pro Thr Phe 
1               5                   


<210>  474
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 474

Gln Gln Ser Asn Glu Asp Pro Tyr Thr 
1               5                   


<210>  475
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 475

Ser Asn Glu Asp Pro Tyr 
1               5       


<210>  476
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 476

Gln Gln Ser Asn Glu Asp Pro Tyr 
1               5               


<210>  477
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 477

Gln Gln Gly Asn Thr Leu Pro Phe Thr 
1               5                   


<210>  478
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 478

Gly Asn Thr Leu Pro Phe 
1               5       


<210>  479
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 479

Gln Gln Gly Asn Thr Leu Pro Phe 
1               5               


<210>  480
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH sequence - 1A3

<400> 480

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Phe Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Met Asn Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Ile Ile Pro Asn Asn Gly Val Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Trp Leu Leu Arg Gly Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Ser Val Thr Val Ser Ser 
        115             


<210>  481
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL sequence - 1A3

<400> 481

Asp Ile Val Met Thr Gln Ala Ala Phe Ser Asn Pro Val Thr Leu Gly 
1               5                   10                  15      


Thr Ser Ala Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Ile Thr Tyr Leu Tyr Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Gln Met Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Ser Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ala Gln His 
                85                  90                  95      


Leu Glu Leu Thr Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  482
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH sequence - P1B6

<400> 482

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Met Asn Trp Val Lys Gln Thr His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Ile Asn Pro Asn Asn Gly Gly Pro Ile Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Asp Ser Ala Trp Phe Thr Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ala 
        115         


<210>  483
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL sequence - P1B6

<400> 483

Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Arg Leu Leu Ile Tyr 
        35                  40                  45              


Asp Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Phe Tyr Ser Ile Thr Ile Ser Arg Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Asn Ser Tyr Pro Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  484
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH sequence - P1H8

<400> 484

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Met Asn Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Ile Asn Pro Asn Asn Gly Gly Thr Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gln Gly Pro Trp Tyr Phe Asp Val Trp Gly Thr Gly Thr Thr 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  485
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL sequence - P1H8

<400> 485

Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Thr Ile Val His Ser 
            20                  25                  30          


Asn Gly Tyr Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  486
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH sequence - P8G4

<400> 486

Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Tyr 
            20                  25                  30          


Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Asp Trp Leu 
        35                  40                  45              


Gly Val Leu Trp Ser Gly Gly Ser Thr Asp Tyr Asn Ala Ala Phe Ile 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Phe Phe 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Ala Asp Asp Thr Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asn Phe Gly Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  487
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL sequence - P8G4

<400> 487

Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Arg Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Asn Asn Asn Pro Pro Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Thr Leu Glu Leu Lys 
            100                 105     


<210>  488
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 488

Gly Phe Thr Phe Thr Asp Tyr Tyr Met Asn 
1               5                   10  


<210>  489
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 489

Gly Tyr Thr Phe Thr Asp Tyr Tyr Met Asn 
1               5                   10  


<210>  490
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 490

Asp Tyr Tyr Met Asn 
1               5   


<210>  491
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 491

Thr Asp Tyr Tyr Met Asn 
1               5       


<210>  492
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 492

Gly Phe Ser Leu Thr Ser Tyr Gly Val His 
1               5                   10  


<210>  493
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 493

Gly Phe Ser Leu Thr Ser Tyr Gly 
1               5               


<210>  494
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 494

Ser Tyr Gly Val His 
1               5   


<210>  495
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 495

Gly Phe Ser Leu Thr Ser Tyr 
1               5           


<210>  496
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 496

Thr Ser Tyr Gly Val His 
1               5       


<210>  497
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 497

Asp Ile Ile Pro Asn Asn Gly Val Thr Ser Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  498
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 498

Ile Ile Pro Asn Asn Gly Val Thr 
1               5               


<210>  499
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 499

Pro Asn Asn Gly 
1               


<210>  500
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 500

Trp Ile Gly Asp Ile Ile Pro Asn Asn Gly Val Thr Ser 
1               5                   10              


<210>  501
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 501

Asp Ile Ile Pro Asn Asn Gly Val Thr Ser 
1               5                   10  


<210>  502
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 502

Asp Ile Asn Pro Asn Asn Gly Gly Pro Ile Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  503
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 503

Ile Asn Pro Asn Asn Gly Gly Pro 
1               5               


<210>  504
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 504

Trp Ile Gly Asp Ile Asn Pro Asn Asn Gly Gly Pro Ile 
1               5                   10              


<210>  505
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 505

Asp Ile Asn Pro Asn Asn Gly Gly Pro Ile 
1               5                   10  


<210>  506
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 506

Asp Ile Asn Pro Asn Asn Gly Gly Thr Thr Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  507
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 507

Ile Asn Pro Asn Asn Gly Gly Thr 
1               5               


<210>  508
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 508

Trp Ile Gly Asp Ile Asn Pro Asn Asn Gly Gly Thr Thr 
1               5                   10              


<210>  509
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 509

Asp Ile Asn Pro Asn Asn Gly Gly Thr Thr 
1               5                   10  


<210>  510
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 510

Val Leu Trp Ser Gly Gly Ser Thr Asp Tyr Asn Ala Ala Phe Ile Ser 
1               5                   10                  15      


<210>  511
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 511

Leu Trp Ser Gly Gly Ser Thr 
1               5           


<210>  512
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 512

Gly Gly Ser 
1           


<210>  513
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 513

Trp Leu Gly Val Leu Trp Ser Gly Gly Ser Thr Asp 
1               5                   10          


<210>  514
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 514

Val Leu Trp Ser Gly Gly Ser Thr Asp 
1               5                   


<210>  515
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 515

Glu Trp Leu Leu Arg Gly Met Asp Tyr 
1               5                   


<210>  516
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 516

Ala Arg Glu Trp Leu Leu Arg Gly Met Asp Tyr 
1               5                   10      


<210>  517
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 517

Trp Leu Leu Arg Gly Met Asp 
1               5           


<210>  518
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 518

Ala Arg Glu Trp Leu Leu Arg Gly Met Asp 
1               5                   10  


<210>  519
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 519

Ser Asp Ser Ala Trp Phe Thr Tyr 
1               5               


<210>  520
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 520

Ala Arg Ser Asp Ser Ala Trp Phe Thr Tyr 
1               5                   10  


<210>  521
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 521

Asp Ser Ala Trp Phe Thr 
1               5       


<210>  522
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 522

Ala Arg Ser Asp Ser Ala Trp Phe Thr 
1               5                   


<210>  523
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 523

Gln Gly Pro Trp Tyr Phe Asp Val 
1               5               


<210>  524
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 524

Ala Arg Gln Gly Pro Trp Tyr Phe Asp Val 
1               5                   10  


<210>  525
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 525

Gly Pro Trp Tyr Phe Asp 
1               5       


<210>  526
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 526

Ala Arg Gln Gly Pro Trp Tyr Phe Asp 
1               5                   


<210>  527
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 527

Asn Phe Gly Asp Tyr 
1               5   


<210>  528
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 528

Ala Arg Asn Phe Gly Asp Tyr 
1               5           


<210>  529
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 529

Phe Gly Asp 
1           


<210>  530
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 530

Ala Arg Asn Phe Gly Asp 
1               5       


<210>  531
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 531

Arg Ser Ser Lys Ser Leu Leu His Ser Asn Gly Ile Thr Tyr Leu Tyr 
1               5                   10                  15      


<210>  532
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 532

Lys Ser Leu Leu His Ser Asn Gly Ile Thr Tyr 
1               5                   10      


<210>  533
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 533

Ser Lys Ser Leu Leu His Ser Asn Gly Ile Thr Tyr 
1               5                   10          


<210>  534
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 534

Leu His Ser Asn Gly Ile Thr Tyr Leu Tyr Trp Tyr 
1               5                   10          


<210>  535
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 535

Ser Ala Ser Ser Ser Val Ser Tyr Met Tyr 
1               5                   10  


<210>  536
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 536

Ser Ser Val Ser Tyr 
1               5   


<210>  537
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 537

Ser Ser Ser Val Ser Tyr 
1               5       


<210>  538
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 538

Ser Tyr Met Tyr Trp Tyr 
1               5       


<210>  539
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 539

Arg Ser Ser Gln Thr Ile Val His Ser Asn Gly Tyr Thr Tyr Leu Glu 
1               5                   10                  15      


<210>  540
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 540

Gln Thr Ile Val His Ser Asn Gly Tyr Thr Tyr 
1               5                   10      


<210>  541
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 541

Ser Gln Thr Ile Val His Ser Asn Gly Tyr Thr Tyr 
1               5                   10          


<210>  542
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 542

Val His Ser Asn Gly Tyr Thr Tyr Leu Glu Trp Tyr 
1               5                   10          


<210>  543
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 543

Ser Ala Ser Ser Arg Val Ser Tyr Met His 
1               5                   10  


<210>  544
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 544

Ser Arg Val Ser Tyr 
1               5   


<210>  545
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 545

Ser Ser Arg Val Ser Tyr 
1               5       


<210>  546
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 546

Ser Tyr Met His Trp Tyr 
1               5       


<210>  547
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 547

Gln Met Ser Asn Leu Ala Ser 
1               5           


<210>  548
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 548

Gln Met Ser 
1           


<210>  549
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 549

Leu Leu Ile Tyr Gln Met Ser Asn Leu Ala 
1               5                   10  


<210>  550
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 550

Asp Thr Ser Asn Leu Ala Ser 
1               5           


<210>  551
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 551

Asp Thr Ser 
1           


<210>  552
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 552

Leu Leu Ile Tyr Asp Thr Ser Asn Leu Ala 
1               5                   10  


<210>  553
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 553

Lys Val Ser Asn Arg Phe Ser 
1               5           


<210>  554
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 554

Lys Val Ser 
1           


<210>  555
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 555

Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe 
1               5                   10  


<210>  556
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 556

Asp Thr Ser Lys Leu Ala Ser 
1               5           


<210>  557
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 557

Arg Trp Ile Tyr Asp Thr Ser Lys Leu Ala 
1               5                   10  


<210>  558
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 558

Ala Gln His Leu Glu Leu Thr Trp Thr 
1               5                   


<210>  559
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 559

His Leu Glu Leu Thr Trp 
1               5       


<210>  560
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 560

Ala Gln His Leu Glu Leu Thr Trp 
1               5               


<210>  561
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 561

Gln Gln Trp Asn Ser Tyr Pro Pro Thr 
1               5                   


<210>  562
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 562

Trp Asn Ser Tyr Pro Pro 
1               5       


<210>  563
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 563

Gln Gln Trp Asn Ser Tyr Pro Pro 
1               5               


<210>  564
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 564

Phe Gln Gly Ser His Val Pro Trp Thr 
1               5                   


<210>  565
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 565

Gln Gly Ser His Val Pro Trp 
1               5           


<210>  566
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 566

Phe Gln Gly Ser His Val Pro Trp 
1               5               


<210>  567
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 567

Gln Gln Trp Asn Asn Asn Pro Pro Thr 
1               5                   


<210>  568
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 568

Trp Asn Asn Asn Pro Pro 
1               5       


<210>  569
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 569

Gln Gln Trp Asn Asn Asn Pro Pro 
1               5               


<210>  570
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 1 (FR1)

<400>  570

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser 
            20                  25  


<210>  571
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 1 (FR1)

<400>  571

Gln Met Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser 
            20                  25  


<210>  572
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 1 (FR1) 

<400>  572

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser 
            20                  25  


<210>  573
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 1 (FR1) 

<400>  573

Gln Ile Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser 
            20                  25  


<210>  574
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 1 (FR1)

<400>  574

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Val Ser 
            20                  25  


<210>  575
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 1 (FR1)

<400>  575

Gln Ile Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Val Ser 
            20                  25  


<210>  576
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 1 (FR1)

<400>  576

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Val Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser 
            20                  25  


<210>  577
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 1 (FR1)

<400>  577

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser 
            20                  25  


<210>  578
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 1 (FR1)

<400>  578

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser 
            20                  25  


<210>  579
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 2 (FR2)

<400>  579

Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile Gly 
1               5                   10                  


<210>  580
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 2 (FR2)

<400>  580

Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu Gly 
1               5                   10                  


<210>  581
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 2 (FR2)

<400>  581

Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
1               5                   10                  


<210>  582
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 2 (FR2)

<400>  582

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met Gly 
1               5                   10                  


<210>  583
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 2 (FR2)

<400>  583

Trp Val Arg Gln Ala Pro Gly Gln Ala Leu Glu Trp Met Gly 
1               5                   10                  


<210>  584
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 2 (FR2)

<400>  584

Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Lys Trp Met Gly 
1               5                   10                  


<210>  585
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 2 (FR2)

<400>  585

Trp Val Arg Gln Ala Pro Gly Lys Ala Leu Glu Trp Met Gly 
1               5                   10                  


<210>  586
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 2 (FR2)

<400>  586

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Lys Trp Met Gly 
1               5                   10                  


<210>  587
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 2 (FR2)

<400>  587

Trp Val Arg Gln Ala Pro Gly Gln Ala Leu Lys Trp Met Gly 
1               5                   10                  


<210>  588
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 2 (FR2)

<400>  588

Trp Val Arg Gln Ala Pro Gly Lys Ala Leu Lys Trp Met Gly 
1               5                   10                  


<210>  589
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 2 (FR2)

<400>  589

Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile Gly 
1               5                   10                  


<210>  590
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 2 (FR2)

<400>  590

Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile Gly 
1               5                   10                  


<210>  591
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 2 (FR2)

<400>  591

Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile Ala 
1               5                   10                  


<210>  592
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 2 (FR2)

<400>  592

Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile Gly 
1               5                   10                  


<210>  593
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 2 (FR2)

<400>  593

Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile Ala 
1               5                   10                  


<210>  594
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 2 (FR2)

<400>  594

Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile Ala 
1               5                   10                  


<210>  595
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 2 (FR2)

<400>  595

Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile Ala 
1               5                   10                  


<210>  596
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 2 (FR2)

<400>  596

Trp Met Gln Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
1               5                   10                  


<210>  597
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 2 (FR2)

<400>  597

Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met Gly 
1               5                   10                  


<210>  598
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 2 (FR2)

<400>  598

Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Ile Gly 
1               5                   10                  


<210>  599
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 2 (FR2)

<400>  599

Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met Ala 
1               5                   10                  


<210>  600
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 2 (FR2)

<400>  600

Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Ile Ala 
1               5                   10                  


<210>  601
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 2 (FR2)

<400>  601

Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met Gly 
1               5                   10                  


<210>  602
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 2 (FR2)

<400>  602

Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Ile Gly 
1               5                   10                  


<210>  603
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  603

Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  604
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  604

Arg Leu Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  605
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  605

Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  606
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  606

Arg Val Thr Ile Ser Val Asp Asn Ser Lys Asn Gln Phe Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  607
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  607

Arg Val Thr Ile Ser Val Asp Thr Ser Lys Ser Gln Phe Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  608
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  608

Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Val Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  609
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  609

Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  610
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  610

Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  611
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  611

Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  612
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  612

Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Val Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  613
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  613

Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Val Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  614
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  614

Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  615
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  615

Arg Leu Thr Ile Ser Val Asp Asn Ser Lys Asn Gln Phe Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  616
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  616

Arg Leu Thr Ile Ser Val Asp Thr Ser Lys Ser Gln Phe Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  617
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  617

Arg Leu Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Val Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  618
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  618

Arg Leu Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  619
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  619

Arg Leu Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  620
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  620

Arg Leu Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  621
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  621

Arg Leu Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Val Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  622
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  622

Arg Leu Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Val Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  623
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  623

Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Phe Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  624
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  624

Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Ser Gln Phe Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  625
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  625

Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  626
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  626

Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Phe Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  627
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  627

Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  628
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  628

Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  629
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  629

Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Val Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  630
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  630

Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Val Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  631
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  631

Arg Val Thr Ile Ser Val Asp Asn Ser Lys Ser Gln Phe Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  632
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  632

Arg Val Thr Ile Ser Val Asp Asn Ser Lys Asn Gln Val Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  633
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  633

Arg Val Thr Ile Ser Val Asp Asn Ser Lys Asn Gln Phe Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  634
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  634

Arg Val Thr Ile Ser Val Asp Asn Ser Lys Asn Gln Phe Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  635
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  635

Arg Val Thr Ile Ser Val Asp Asn Ser Lys Asn Gln Phe Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  636
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  636

Arg Val Thr Ile Ser Val Asp Asn Ser Lys Asn Gln Phe Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Val Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  637
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  637

Arg Val Thr Ile Ser Val Asp Asn Ser Lys Asn Gln Phe Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Val Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  638
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  638

Arg Val Thr Ile Ser Val Asp Thr Ser Lys Ser Gln Val Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  639
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  639

Arg Val Thr Ile Ser Val Asp Thr Ser Lys Ser Gln Phe Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  640
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  640

Arg Val Thr Ile Ser Val Asp Thr Ser Lys Ser Gln Phe Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  641
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  641

Arg Val Thr Ile Ser Val Asp Thr Ser Lys Ser Gln Phe Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  642
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  642

Arg Val Thr Ile Ser Val Asp Thr Ser Lys Ser Gln Phe Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Val Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  643
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  643

Arg Val Thr Ile Ser Val Asp Thr Ser Lys Ser Gln Phe Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Val Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  644
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  644

Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Val Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  645
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  645

Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Val Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  646
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  646

Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Val Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  647
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  647

Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Val Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Val Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  648
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  648

Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Val Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Val Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  649
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  649

Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  650
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  650

Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  651
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  651

Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Val Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  652
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  652

Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Val Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  653
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  653

Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  654
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  654

Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Val Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  655
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  655

Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Val Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  656
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  656

Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Leu Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  657
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  657

Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Leu Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  658
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  658

Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Val Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  659
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  659

Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Phe Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  660
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  660

Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Ser Gln Phe Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  661
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  661

Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  662
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  662

Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Phe Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  663
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  663

Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  664
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  664

Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  665
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  665

Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Val Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  666
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  666

Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Val Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  667
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  667

Arg Leu Thr Ile Ser Val Asp Asn Ser Lys Ser Gln Phe Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  668
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  668

Arg Leu Thr Ile Ser Val Asp Asn Ser Lys Asn Gln Val Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  669
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  669

Arg Leu Thr Ile Ser Val Asp Asn Ser Lys Asn Gln Phe Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  670
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  670

Arg Leu Thr Ile Ser Val Asp Asn Ser Lys Asn Gln Phe Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  671
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  671

Arg Leu Thr Ile Ser Val Asp Asn Ser Lys Asn Gln Phe Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  672
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  672

Arg Leu Thr Ile Ser Val Asp Asn Ser Lys Asn Gln Phe Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Val Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  673
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  673

Arg Leu Thr Ile Ser Val Asp Asn Ser Lys Asn Gln Phe Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Val Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  674
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  674

Arg Leu Thr Ile Ser Val Asp Thr Ser Lys Ser Gln Val Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  675
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  675

Arg Leu Thr Ile Ser Val Asp Thr Ser Lys Ser Gln Phe Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  676
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  676

Arg Leu Thr Ile Ser Val Asp Thr Ser Lys Ser Gln Phe Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  677
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  677

Arg Leu Thr Ile Ser Val Asp Thr Ser Lys Ser Gln Phe Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  678
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  678

Arg Leu Thr Ile Ser Val Asp Thr Ser Lys Ser Gln Phe Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Val Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  679
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  679

Arg Leu Thr Ile Ser Val Asp Thr Ser Lys Ser Gln Phe Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Val Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  680
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  680

Arg Leu Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Val Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  681
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  681

Arg Leu Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Val Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  682
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  682

Arg Leu Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Val Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  683
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  683

Arg Leu Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Val Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Val Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  684
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  684

Arg Leu Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Val Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Val Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  685
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  685

Arg Leu Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  686
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  686

Arg Leu Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  687
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  687

Arg Leu Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Val Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  688
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  688

Arg Leu Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Val Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  689
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  689

Arg Leu Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  690
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  690

Arg Leu Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Val Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  691
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  691

Arg Leu Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Val Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  692
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  692

Arg Leu Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Leu Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  693
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  693

Arg Leu Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Leu Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  694
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  694

Arg Leu Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Val Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  695
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  695

Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Ser Gln Phe Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  696
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  696

Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Val Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  697
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  697

Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Phe Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  698
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  698

Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Phe Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  699
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  699

Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Phe Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  700
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  700

Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Phe Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Val Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  701
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  701

Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Phe Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Val Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  702
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  702

Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Ser Gln Val Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  703
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  703

Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Ser Gln Phe Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  704
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  704

Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Ser Gln Phe Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  705
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  705

Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Ser Gln Phe Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  706
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  706

Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Ser Gln Phe Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Val Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  707
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  707

Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Ser Gln Phe Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Val Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  708
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  708

Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  709
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  709

Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  710
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  710

Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  711
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  711

Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Val Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  712
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  712

Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Val Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  713
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  713

Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Phe Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  714
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  714

Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Phe Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  715
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  715

Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Phe Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Val Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  716
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  716

Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Phe Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Val Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  717
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  717

Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  718
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  718

Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Val Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  719
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  719

Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Val Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  720
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  720

Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Leu Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  721
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  721

Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Leu Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  722
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  722

Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Val Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  723
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  723

Arg Val Thr Ile Ser Val Asp Asn Ser Lys Ser Gln Val Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  724
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  724

Arg Val Thr Ile Ser Val Asp Asn Ser Lys Ser Gln Phe Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  725
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  725

Arg Val Thr Ile Ser Val Asp Asn Ser Lys Ser Gln Phe Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  726
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  726

Arg Val Thr Ile Ser Val Asp Asn Ser Lys Ser Gln Phe Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  727
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  727

Arg Val Thr Ile Ser Val Asp Asn Ser Lys Ser Gln Phe Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Val Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  728
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  728

Arg Val Thr Ile Ser Val Asp Asn Ser Lys Ser Gln Phe Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Val Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  729
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  729

Arg Val Thr Ile Ser Val Asp Asn Ser Lys Asn Gln Val Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  730
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  730

Arg Val Thr Ile Ser Val Asp Asn Ser Lys Asn Gln Val Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  731
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  731

Arg Val Thr Ile Ser Val Asp Asn Ser Lys Asn Gln Val Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  732
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  732

Arg Val Thr Ile Ser Val Asp Asn Ser Lys Asn Gln Val Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Val Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  733
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  733

Arg Val Thr Ile Ser Val Asp Asn Ser Lys Asn Gln Val Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Val Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  734
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  734

Arg Val Thr Ile Ser Val Asp Asn Ser Lys Asn Gln Phe Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  735
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  735

Arg Val Thr Ile Ser Val Asp Asn Ser Lys Asn Gln Phe Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  736
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  736

Arg Val Thr Ile Ser Val Asp Asn Ser Lys Asn Gln Phe Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Val Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  737
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  737

Arg Val Thr Ile Ser Val Asp Asn Ser Lys Asn Gln Phe Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Val Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  738
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  738

Arg Val Thr Ile Ser Val Asp Asn Ser Lys Asn Gln Phe Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  739
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  739

Arg Val Thr Ile Ser Val Asp Asn Ser Lys Asn Gln Phe Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Val Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  740
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  740

Arg Val Thr Ile Ser Val Asp Asn Ser Lys Asn Gln Phe Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Val Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  741
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  741

Arg Val Thr Ile Ser Val Asp Asn Ser Lys Asn Gln Phe Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Leu Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  742
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  742

Arg Val Thr Ile Ser Val Asp Asn Ser Lys Asn Gln Phe Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Leu Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  743
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  743

Arg Val Thr Ile Ser Val Asp Asn Ser Lys Asn Gln Phe Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Val Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  744
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  744

Arg Val Thr Ile Ser Val Asp Thr Ser Lys Ser Gln Val Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  745
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  745

Arg Val Thr Ile Ser Val Asp Thr Ser Lys Ser Gln Val Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  746
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  746

Arg Val Thr Ile Ser Val Asp Thr Ser Lys Ser Gln Val Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  747
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  747

Arg Val Thr Ile Ser Val Asp Thr Ser Lys Ser Gln Val Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Val Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  748
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  748

Arg Val Thr Ile Ser Val Asp Thr Ser Lys Ser Gln Val Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Val Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  749
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  749

Arg Val Thr Ile Ser Val Asp Thr Ser Lys Ser Gln Phe Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  750
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  750

Arg Val Thr Ile Ser Val Asp Thr Ser Lys Ser Gln Phe Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  751
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  751

Arg Val Thr Ile Ser Val Asp Thr Ser Lys Ser Gln Phe Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Val Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  752
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  752

Arg Val Thr Ile Ser Val Asp Thr Ser Lys Ser Gln Phe Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Val Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  753
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  753

Arg Val Thr Ile Ser Val Asp Thr Ser Lys Ser Gln Phe Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  754
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  754

Arg Val Thr Ile Ser Val Asp Thr Ser Lys Ser Gln Phe Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Val Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  755
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  755

Arg Val Thr Ile Ser Val Asp Thr Ser Lys Ser Gln Phe Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Val Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  756
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  756

Arg Val Thr Ile Ser Val Asp Thr Ser Lys Ser Gln Phe Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Leu Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  757
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  757

Arg Val Thr Ile Ser Val Asp Thr Ser Lys Ser Gln Phe Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Leu Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  758
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  758

Arg Val Thr Ile Ser Val Asp Thr Ser Lys Ser Gln Phe Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Val Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  759
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  759

Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Val Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  760
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  760

Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Val Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  761
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  761

Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Val Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Val Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  762
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  762

Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Val Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Val Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  763
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  763

Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Val Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  764
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  764

Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Val Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Val Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  765
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  765

Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Val Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Val Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  766
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  766

Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Val Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Leu Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  767
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  767

Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Val Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Leu Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  768
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  768

Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Val Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Val Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  769
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  769

Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  770
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  770

Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Val Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  771
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  771

Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Val Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  772
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  772

Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Leu Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  773
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  773

Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Leu Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  774
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  774

Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Val Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  775
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  775

Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Leu Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  776
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  776

Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Leu Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  777
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  777

Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Val Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  778
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  778

Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Leu Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  779
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  779

Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Ser Gln Phe Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  780
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  780

Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Val Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  781
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  781

Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Phe Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  782
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  782

Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Phe Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  783
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  783

Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Phe Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  784
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  784

Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Phe Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Val Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  785
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  785

Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Phe Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Val Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  786
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  786

Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Ser Gln Val Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  787
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  787

Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Ser Gln Phe Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  788
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  788

Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Ser Gln Phe Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  789
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  789

Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Ser Gln Phe Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  790
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  790

Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Ser Gln Phe Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Val Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  791
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  791

Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Ser Gln Phe Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Val Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  792
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  792

Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  793
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  793

Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  794
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  794

Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  795
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  795

Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Val Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  796
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  796

Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Val Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  797
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  797

Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Phe Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  798
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  798

Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Phe Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  799
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  799

Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Phe Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Val Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  800
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  800

Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Phe Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Val Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  801
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  801

Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  802
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  802

Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Val Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  803
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  803

Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Val Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  804
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  804

Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Leu Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  805
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  805

Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Leu Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  806
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  806

Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Val Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  807
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  807

Arg Leu Thr Ile Ser Val Asp Asn Ser Lys Ser Gln Val Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  808
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  808

Arg Leu Thr Ile Ser Val Asp Asn Ser Lys Ser Gln Phe Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  809
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  809

Arg Leu Thr Ile Ser Val Asp Asn Ser Lys Ser Gln Phe Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  810
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  810

Arg Leu Thr Ile Ser Val Asp Asn Ser Lys Ser Gln Phe Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  811
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  811

Arg Leu Thr Ile Ser Val Asp Asn Ser Lys Ser Gln Phe Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Val Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  812
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  812

Arg Leu Thr Ile Ser Val Asp Asn Ser Lys Ser Gln Phe Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Val Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  813
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  813

Arg Leu Thr Ile Ser Val Asp Asn Ser Lys Asn Gln Val Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  814
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  814

Arg Leu Thr Ile Ser Val Asp Asn Ser Lys Asn Gln Val Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  815
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  815

Arg Leu Thr Ile Ser Val Asp Asn Ser Lys Asn Gln Val Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  816
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  816

Arg Leu Thr Ile Ser Val Asp Asn Ser Lys Asn Gln Val Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Val Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  817
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  817

Arg Leu Thr Ile Ser Val Asp Asn Ser Lys Asn Gln Val Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Val Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  818
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  818

Arg Leu Thr Ile Ser Val Asp Asn Ser Lys Asn Gln Phe Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  819
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  819

Arg Leu Thr Ile Ser Val Asp Asn Ser Lys Asn Gln Phe Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  820
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  820

Arg Leu Thr Ile Ser Val Asp Asn Ser Lys Asn Gln Phe Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Val Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  821
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  821

Arg Leu Thr Ile Ser Val Asp Asn Ser Lys Asn Gln Phe Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Val Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  822
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  822

Arg Leu Thr Ile Ser Val Asp Asn Ser Lys Asn Gln Phe Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  823
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  823

Arg Leu Thr Ile Ser Val Asp Asn Ser Lys Asn Gln Phe Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Val Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  824
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  824

Arg Leu Thr Ile Ser Val Asp Asn Ser Lys Asn Gln Phe Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Val Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  825
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  825

Arg Leu Thr Ile Ser Val Asp Asn Ser Lys Asn Gln Phe Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Leu Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  826
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  826

Arg Leu Thr Ile Ser Val Asp Asn Ser Lys Asn Gln Phe Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Leu Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  827
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  827

Arg Leu Thr Ile Ser Val Asp Asn Ser Lys Asn Gln Phe Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Val Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  828
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  828

Arg Leu Thr Ile Ser Val Asp Thr Ser Lys Ser Gln Val Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  829
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  829

Arg Leu Thr Ile Ser Val Asp Thr Ser Lys Ser Gln Val Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  830
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  830

Arg Leu Thr Ile Ser Val Asp Thr Ser Lys Ser Gln Val Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  831
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  831

Arg Leu Thr Ile Ser Val Asp Thr Ser Lys Ser Gln Val Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Val Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  832
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  832

Arg Leu Thr Ile Ser Val Asp Thr Ser Lys Ser Gln Val Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Val Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  833
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  833

Arg Leu Thr Ile Ser Val Asp Thr Ser Lys Ser Gln Phe Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  834
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  834

Arg Leu Thr Ile Ser Val Asp Thr Ser Lys Ser Gln Phe Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  835
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  835

Arg Leu Thr Ile Ser Val Asp Thr Ser Lys Ser Gln Phe Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Val Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  836
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  836

Arg Leu Thr Ile Ser Val Asp Thr Ser Lys Ser Gln Phe Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Val Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  837
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  837

Arg Leu Thr Ile Ser Val Asp Thr Ser Lys Ser Gln Phe Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  838
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  838

Arg Leu Thr Ile Ser Val Asp Thr Ser Lys Ser Gln Phe Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Val Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  839
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  839

Arg Leu Thr Ile Ser Val Asp Thr Ser Lys Ser Gln Phe Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Val Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  840
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  840

Arg Leu Thr Ile Ser Val Asp Thr Ser Lys Ser Gln Phe Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Leu Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  841
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  841

Arg Leu Thr Ile Ser Val Asp Thr Ser Lys Ser Gln Phe Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Leu Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  842
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  842

Arg Leu Thr Ile Ser Val Asp Thr Ser Lys Ser Gln Phe Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Val Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  843
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  843

Arg Leu Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Val Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  844
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  844

Arg Leu Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Val Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  845
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  845

Arg Leu Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Val Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Val Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  846
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  846

Arg Leu Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Val Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Val Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  847
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  847

Arg Leu Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Val Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  848
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  848

Arg Leu Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Val Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Val Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  849
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  849

Arg Leu Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Val Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Val Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  850
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  850

Arg Leu Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Val Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Leu Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  851
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  851

Arg Leu Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Val Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Leu Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  852
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  852

Arg Leu Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Val Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Val Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  853
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  853

Arg Leu Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  854
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  854

Arg Leu Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Val Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  855
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  855

Arg Leu Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Val Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  856
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  856

Arg Leu Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Leu Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  857
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  857

Arg Leu Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Leu Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  858
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  858

Arg Leu Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Val Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  859
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  859

Arg Leu Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Leu Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  860
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  860

Arg Leu Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Leu Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  861
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  861

Arg Leu Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Val Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  862
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  862

Arg Leu Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Leu Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  863
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  863

Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  864
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  864

Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Ser Gln Phe Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  865
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  865

Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Ser Gln Phe Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  866
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  866

Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Ser Gln Phe Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  867
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  867

Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Ser Gln Phe Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Val Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  868
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  868

Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Ser Gln Phe Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Val Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  869
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  869

Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Val Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  870
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  870

Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Val Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  871
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  871

Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Val Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  872
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  872

Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Val Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Val Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  873
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  873

Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Val Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Val Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  874
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  874

Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Phe Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  875
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  875

Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Phe Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  876
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  876

Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Phe Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Val Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  877
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  877

Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Phe Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Val Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  878
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  878

Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Phe Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  879
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  879

Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Phe Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Val Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  880
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  880

Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Phe Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Val Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  881
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  881

Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Phe Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Leu Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  882
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  882

Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Phe Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Leu Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  883
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  883

Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Phe Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Val Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  884
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  884

Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Ser Gln Val Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  885
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  885

Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Ser Gln Val Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  886
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  886

Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Ser Gln Val Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  887
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  887

Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Ser Gln Val Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Val Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  888
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  888

Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Ser Gln Val Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Val Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  889
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  889

Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Ser Gln Phe Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  890
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  890

Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Ser Gln Phe Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  891
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  891

Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Ser Gln Phe Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Val Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  892
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  892

Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Ser Gln Phe Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Val Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  893
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  893

Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Ser Gln Phe Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  894
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  894

Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Ser Gln Phe Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Val Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  895
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  895

Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Ser Gln Phe Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Val Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  896
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  896

Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Ser Gln Phe Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Leu Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  897
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  897

Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Ser Gln Phe Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Leu Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  898
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  898

Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Ser Gln Phe Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Val Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  899
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  899

Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  900
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  900

Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  901
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  901

Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Val Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  902
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  902

Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Val Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  903
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  903

Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  904
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  904

Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Val Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  905
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  905

Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Val Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  906
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  906

Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Leu Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  907
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  907

Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Leu Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  908
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  908

Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Val Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  909
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  909

Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Phe Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  910
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  910

Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Phe Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Val Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  911
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  911

Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Phe Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Val Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  912
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  912

Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Phe Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Leu Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  913
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  913

Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Phe Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Leu Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  914
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  914

Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Phe Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Val Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  915
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  915

Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Leu Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  916
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  916

Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Leu Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  917
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  917

Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Val Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  918
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  918

Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Leu Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  919
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  919

Arg Val Thr Ile Ser Val Asp Asn Ser Lys Ser Gln Val Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  920
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  920

Arg Val Thr Ile Ser Val Asp Asn Ser Lys Ser Gln Val Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  921
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  921

Arg Val Thr Ile Ser Val Asp Asn Ser Lys Ser Gln Val Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  922
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  922

Arg Val Thr Ile Ser Val Asp Asn Ser Lys Ser Gln Val Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Val Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  923
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  923

Arg Val Thr Ile Ser Val Asp Asn Ser Lys Ser Gln Val Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Val Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  924
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  924

Arg Val Thr Ile Ser Val Asp Asn Ser Lys Ser Gln Phe Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  925
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  925

Arg Val Thr Ile Ser Val Asp Asn Ser Lys Ser Gln Phe Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  926
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  926

Arg Val Thr Ile Ser Val Asp Asn Ser Lys Ser Gln Phe Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Val Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  927
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  927

Arg Val Thr Ile Ser Val Asp Asn Ser Lys Ser Gln Phe Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Val Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  928
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  928

Arg Val Thr Ile Ser Val Asp Asn Ser Lys Ser Gln Phe Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  929
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  929

Arg Val Thr Ile Ser Val Asp Asn Ser Lys Ser Gln Phe Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Val Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  930
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  930

Arg Val Thr Ile Ser Val Asp Asn Ser Lys Ser Gln Phe Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Val Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  931
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  931

Arg Val Thr Ile Ser Val Asp Asn Ser Lys Ser Gln Phe Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Leu Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  932
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  932

Arg Val Thr Ile Ser Val Asp Asn Ser Lys Ser Gln Phe Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Leu Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  933
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  933

Arg Val Thr Ile Ser Val Asp Asn Ser Lys Ser Gln Phe Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Val Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  934
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  934

Arg Val Thr Ile Ser Val Asp Asn Ser Lys Asn Gln Val Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  935
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  935

Arg Val Thr Ile Ser Val Asp Asn Ser Lys Asn Gln Val Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  936
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  936

Arg Val Thr Ile Ser Val Asp Asn Ser Lys Asn Gln Val Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Val Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  937
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  937

Arg Val Thr Ile Ser Val Asp Asn Ser Lys Asn Gln Val Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Val Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  938
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  938

Arg Val Thr Ile Ser Val Asp Asn Ser Lys Asn Gln Val Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  939
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  939

Arg Val Thr Ile Ser Val Asp Asn Ser Lys Asn Gln Val Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Val Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  940
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  940

Arg Val Thr Ile Ser Val Asp Asn Ser Lys Asn Gln Val Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Val Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  941
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  941

Arg Val Thr Ile Ser Val Asp Asn Ser Lys Asn Gln Val Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Leu Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  942
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  942

Arg Val Thr Ile Ser Val Asp Asn Ser Lys Asn Gln Val Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Leu Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  943
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  943

Arg Val Thr Ile Ser Val Asp Asn Ser Lys Asn Gln Val Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Val Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  944
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  944

Arg Val Thr Ile Ser Val Asp Asn Ser Lys Asn Gln Phe Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  945
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  945

Arg Val Thr Ile Ser Val Asp Asn Ser Lys Asn Gln Phe Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Val Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  946
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  946

Arg Val Thr Ile Ser Val Asp Asn Ser Lys Asn Gln Phe Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Val Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  947
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  947

Arg Val Thr Ile Ser Val Asp Asn Ser Lys Asn Gln Phe Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Leu Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  948
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  948

Arg Val Thr Ile Ser Val Asp Asn Ser Lys Asn Gln Phe Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Leu Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  949
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  949

Arg Val Thr Ile Ser Val Asp Asn Ser Lys Asn Gln Phe Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Val Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  950
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  950

Arg Val Thr Ile Ser Val Asp Asn Ser Lys Asn Gln Phe Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Leu Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  951
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  951

Arg Val Thr Ile Ser Val Asp Asn Ser Lys Asn Gln Phe Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Leu Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  952
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  952

Arg Val Thr Ile Ser Val Asp Asn Ser Lys Asn Gln Phe Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Val Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  953
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  953

Arg Val Thr Ile Ser Val Asp Asn Ser Lys Asn Gln Phe Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Leu Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  954
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  954

Arg Val Thr Ile Ser Val Asp Thr Ser Lys Ser Gln Val Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  955
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  955

Arg Val Thr Ile Ser Val Asp Thr Ser Lys Ser Gln Val Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  956
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  956

Arg Val Thr Ile Ser Val Asp Thr Ser Lys Ser Gln Val Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Val Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  957
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  957

Arg Val Thr Ile Ser Val Asp Thr Ser Lys Ser Gln Val Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Val Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  958
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  958

Arg Val Thr Ile Ser Val Asp Thr Ser Lys Ser Gln Val Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  959
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  959

Arg Val Thr Ile Ser Val Asp Thr Ser Lys Ser Gln Val Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Val Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  960
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  960

Arg Val Thr Ile Ser Val Asp Thr Ser Lys Ser Gln Val Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Val Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  961
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  961

Arg Val Thr Ile Ser Val Asp Thr Ser Lys Ser Gln Val Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Leu Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  962
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  962

Arg Val Thr Ile Ser Val Asp Thr Ser Lys Ser Gln Val Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Leu Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  963
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  963

Arg Val Thr Ile Ser Val Asp Thr Ser Lys Ser Gln Val Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Val Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  964
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  964

Arg Val Thr Ile Ser Val Asp Thr Ser Lys Ser Gln Phe Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  965
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  965

Arg Val Thr Ile Ser Val Asp Thr Ser Lys Ser Gln Phe Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Val Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  966
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  966

Arg Val Thr Ile Ser Val Asp Thr Ser Lys Ser Gln Phe Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Val Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  967
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  967

Arg Val Thr Ile Ser Val Asp Thr Ser Lys Ser Gln Phe Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Leu Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  968
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  968

Arg Val Thr Ile Ser Val Asp Thr Ser Lys Ser Gln Phe Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Leu Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  969
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  969

Arg Val Thr Ile Ser Val Asp Thr Ser Lys Ser Gln Phe Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Val Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  970
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  970

Arg Val Thr Ile Ser Val Asp Thr Ser Lys Ser Gln Phe Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Leu Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  971
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  971

Arg Val Thr Ile Ser Val Asp Thr Ser Lys Ser Gln Phe Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Leu Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  972
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  972

Arg Val Thr Ile Ser Val Asp Thr Ser Lys Ser Gln Phe Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Val Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  973
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  973

Arg Val Thr Ile Ser Val Asp Thr Ser Lys Ser Gln Phe Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Leu Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  974
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  974

Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Val Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  975
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  975

Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Val Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Val Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  976
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  976

Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Val Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Val Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  977
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  977

Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Val Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Leu Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  978
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  978

Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Val Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Leu Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  979
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  979

Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Val Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Val Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  980
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  980

Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Val Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Leu Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  981
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  981

Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Val Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Leu Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  982
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  982

Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Val Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Val Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  983
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  983

Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Val Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Leu Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  984
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  984

Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Leu Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  985
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  985

Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Leu Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  986
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  986

Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Val Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  987
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  987

Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Leu Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  988
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  988

Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Leu Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  989
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  989

Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  990
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  990

Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Ser Gln Phe Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  991
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  991

Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Ser Gln Phe Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  992
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  992

Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Ser Gln Phe Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  993
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  993

Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Ser Gln Phe Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Val Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  994
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  994

Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Ser Gln Phe Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Val Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  995
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  995

Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Val Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  996
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  996

Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Val Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  997
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  997

Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Val Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  998
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  998

Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Val Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Val Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  999
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  999

Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Val Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Val Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1000
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1000

Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Phe Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1001
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1001

Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Phe Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1002
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1002

Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Phe Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Val Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1003
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1003

Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Phe Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Val Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1004
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1004

Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Phe Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1005
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1005

Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Phe Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Val Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1006
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1006

Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Phe Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Val Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1007
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1007

Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Phe Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Leu Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1008
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1008

Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Phe Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Leu Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1009
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1009

Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Phe Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Val Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1010
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1010

Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Ser Gln Val Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1011
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1011

Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Ser Gln Val Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1012
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1012

Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Ser Gln Val Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1013
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1013

Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Ser Gln Val Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Val Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1014
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1014

Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Ser Gln Val Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Val Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1015
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1015

Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Ser Gln Phe Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1016
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1016

Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Ser Gln Phe Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1017
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1017

Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Ser Gln Phe Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Val Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1018
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1018

Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Ser Gln Phe Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Val Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1019
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1019

Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Ser Gln Phe Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1020
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1020

Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Ser Gln Phe Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Val Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1021
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1021

Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Ser Gln Phe Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Val Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1022
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1022

Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Ser Gln Phe Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Leu Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1023
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1023

Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Ser Gln Phe Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Leu Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1024
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1024

Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Ser Gln Phe Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Val Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1025
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1025

Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1026
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1026

Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1027
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1027

Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Val Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1028
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1028

Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Val Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1029
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1029

Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1030
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1030

Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Val Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1031
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1031

Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Val Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1032
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1032

Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Leu Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1033
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1033

Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Leu Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1034
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1034

Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Val Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1035
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1035

Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Phe Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1036
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1036

Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Phe Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Val Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1037
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1037

Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Phe Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Val Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1038
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1038

Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Phe Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Leu Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1039
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1039

Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Phe Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Leu Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1040
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1040

Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Phe Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Val Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1041
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1041

Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Leu Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1042
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1042

Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Leu Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1043
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1043

Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Val Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1044
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1044

Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Leu Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1045
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1045

Arg Leu Thr Ile Ser Val Asp Asn Ser Lys Ser Gln Val Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1046
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1046

Arg Leu Thr Ile Ser Val Asp Asn Ser Lys Ser Gln Val Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1047
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1047

Arg Leu Thr Ile Ser Val Asp Asn Ser Lys Ser Gln Val Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1048
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1048

Arg Leu Thr Ile Ser Val Asp Asn Ser Lys Ser Gln Val Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Val Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1049
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1049

Arg Leu Thr Ile Ser Val Asp Asn Ser Lys Ser Gln Val Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Val Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1050
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1050

Arg Leu Thr Ile Ser Val Asp Asn Ser Lys Ser Gln Phe Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1051
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1051

Arg Leu Thr Ile Ser Val Asp Asn Ser Lys Ser Gln Phe Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1052
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1052

Arg Leu Thr Ile Ser Val Asp Asn Ser Lys Ser Gln Phe Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Val Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1053
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1053

Arg Leu Thr Ile Ser Val Asp Asn Ser Lys Ser Gln Phe Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Val Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1054
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1054

Arg Leu Thr Ile Ser Val Asp Asn Ser Lys Ser Gln Phe Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1055
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1055

Arg Leu Thr Ile Ser Val Asp Asn Ser Lys Ser Gln Phe Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Val Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1056
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1056

Arg Leu Thr Ile Ser Val Asp Asn Ser Lys Ser Gln Phe Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Val Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1057
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1057

Arg Leu Thr Ile Ser Val Asp Asn Ser Lys Ser Gln Phe Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Leu Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1058
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1058

Arg Leu Thr Ile Ser Val Asp Asn Ser Lys Ser Gln Phe Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Leu Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1059
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1059

Arg Leu Thr Ile Ser Val Asp Asn Ser Lys Ser Gln Phe Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Val Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1060
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1060

Arg Leu Thr Ile Ser Val Asp Asn Ser Lys Asn Gln Val Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1061
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1061

Arg Leu Thr Ile Ser Val Asp Asn Ser Lys Asn Gln Val Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1062
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1062

Arg Leu Thr Ile Ser Val Asp Asn Ser Lys Asn Gln Val Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Val Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1063
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1063

Arg Leu Thr Ile Ser Val Asp Asn Ser Lys Asn Gln Val Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Val Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1064
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1064

Arg Leu Thr Ile Ser Val Asp Asn Ser Lys Asn Gln Val Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1065
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1065

Arg Leu Thr Ile Ser Val Asp Asn Ser Lys Asn Gln Val Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Val Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1066
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1066

Arg Leu Thr Ile Ser Val Asp Asn Ser Lys Asn Gln Val Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Val Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1067
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1067

Arg Leu Thr Ile Ser Val Asp Asn Ser Lys Asn Gln Val Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Leu Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1068
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1068

Arg Leu Thr Ile Ser Val Asp Asn Ser Lys Asn Gln Val Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Leu Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1069
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1069

Arg Leu Thr Ile Ser Val Asp Asn Ser Lys Asn Gln Val Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Val Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1070
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1070

Arg Leu Thr Ile Ser Val Asp Asn Ser Lys Asn Gln Phe Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1071
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1071

Arg Leu Thr Ile Ser Val Asp Asn Ser Lys Asn Gln Phe Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Val Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1072
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1072

Arg Leu Thr Ile Ser Val Asp Asn Ser Lys Asn Gln Phe Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Val Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1073
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1073

Arg Leu Thr Ile Ser Val Asp Asn Ser Lys Asn Gln Phe Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Leu Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1074
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1074

Arg Leu Thr Ile Ser Val Asp Asn Ser Lys Asn Gln Phe Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Leu Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1075
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1075

Arg Leu Thr Ile Ser Val Asp Asn Ser Lys Asn Gln Phe Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Val Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1076
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1076

Arg Leu Thr Ile Ser Val Asp Asn Ser Lys Asn Gln Phe Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Leu Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1077
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1077

Arg Leu Thr Ile Ser Val Asp Asn Ser Lys Asn Gln Phe Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Leu Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1078
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1078

Arg Leu Thr Ile Ser Val Asp Asn Ser Lys Asn Gln Phe Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Val Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1079
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1079

Arg Leu Thr Ile Ser Val Asp Asn Ser Lys Asn Gln Phe Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Leu Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1080
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1080

Arg Leu Thr Ile Ser Val Asp Thr Ser Lys Ser Gln Val Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1081
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1081

Arg Leu Thr Ile Ser Val Asp Thr Ser Lys Ser Gln Val Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1082
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1082

Arg Leu Thr Ile Ser Val Asp Thr Ser Lys Ser Gln Val Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Val Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1083
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1083

Arg Leu Thr Ile Ser Val Asp Thr Ser Lys Ser Gln Val Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Val Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1084
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1084

Arg Leu Thr Ile Ser Val Asp Thr Ser Lys Ser Gln Val Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1085
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1085

Arg Leu Thr Ile Ser Val Asp Thr Ser Lys Ser Gln Val Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Val Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1086
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1086

Arg Leu Thr Ile Ser Val Asp Thr Ser Lys Ser Gln Val Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Val Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1087
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1087

Arg Leu Thr Ile Ser Val Asp Thr Ser Lys Ser Gln Val Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Leu Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1088
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1088

Arg Leu Thr Ile Ser Val Asp Thr Ser Lys Ser Gln Val Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Leu Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1089
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1089

Arg Leu Thr Ile Ser Val Asp Thr Ser Lys Ser Gln Val Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Val Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1090
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1090

Arg Leu Thr Ile Ser Val Asp Thr Ser Lys Ser Gln Phe Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1091
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1091

Arg Leu Thr Ile Ser Val Asp Thr Ser Lys Ser Gln Phe Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Val Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1092
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1092

Arg Leu Thr Ile Ser Val Asp Thr Ser Lys Ser Gln Phe Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Val Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1093
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1093

Arg Leu Thr Ile Ser Val Asp Thr Ser Lys Ser Gln Phe Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Leu Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1094
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1094

Arg Leu Thr Ile Ser Val Asp Thr Ser Lys Ser Gln Phe Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Leu Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1095
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1095

Arg Leu Thr Ile Ser Val Asp Thr Ser Lys Ser Gln Phe Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Val Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1096
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1096

Arg Leu Thr Ile Ser Val Asp Thr Ser Lys Ser Gln Phe Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Leu Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1097
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1097

Arg Leu Thr Ile Ser Val Asp Thr Ser Lys Ser Gln Phe Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Leu Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1098
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1098

Arg Leu Thr Ile Ser Val Asp Thr Ser Lys Ser Gln Phe Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Val Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1099
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1099

Arg Leu Thr Ile Ser Val Asp Thr Ser Lys Ser Gln Phe Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Leu Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1100
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1100

Arg Leu Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Val Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1101
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1101

Arg Leu Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Val Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Val Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1102
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1102

Arg Leu Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Val Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Val Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1103
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1103

Arg Leu Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Val Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Leu Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1104
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1104

Arg Leu Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Val Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Leu Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1105
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1105

Arg Leu Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Val Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Val Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1106
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1106

Arg Leu Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Val Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Leu Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1107
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1107

Arg Leu Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Val Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Leu Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1108
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1108

Arg Leu Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Val Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Val Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1109
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1109

Arg Leu Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Val Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Leu Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1110
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1110

Arg Leu Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Leu Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1111
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1111

Arg Leu Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Leu Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1112
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1112

Arg Leu Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Val Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1113
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1113

Arg Leu Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Leu Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1114
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1114

Arg Leu Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Leu Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1115
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1115

Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1116
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1116

Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1117
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1117

Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1118
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1118

Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Val Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1119
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1119

Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Val Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1120
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1120

Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Ser Gln Phe Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1121
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1121

Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Ser Gln Phe Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1122
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1122

Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Ser Gln Phe Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Val Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1123
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1123

Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Ser Gln Phe Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Val Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1124
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1124

Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Ser Gln Phe Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1125
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1125

Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Ser Gln Phe Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Val Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1126
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1126

Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Ser Gln Phe Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Val Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1127
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1127

Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Ser Gln Phe Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Leu Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1128
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1128

Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Ser Gln Phe Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Leu Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1129
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1129

Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Ser Gln Phe Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Val Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1130
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1130

Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Val Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1131
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1131

Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Val Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1132
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1132

Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Val Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Val Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1133
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1133

Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Val Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Val Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1134
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1134

Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Val Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1135
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1135

Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Val Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Val Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1136
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1136

Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Val Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Val Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1137
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1137

Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Val Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Leu Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1138
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1138

Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Val Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Leu Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1139
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1139

Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Val Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Val Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1140
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1140

Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Phe Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1141
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1141

Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Phe Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Val Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1142
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1142

Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Phe Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Val Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1143
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1143

Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Phe Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Leu Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1144
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1144

Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Phe Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Leu Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1145
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1145

Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Phe Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Val Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1146
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1146

Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Phe Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Leu Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1147
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1147

Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Phe Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Leu Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1148
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1148

Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Phe Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Val Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1149
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1149

Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Phe Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Leu Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1150
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1150

Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Ser Gln Val Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1151
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1151

Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Ser Gln Val Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1152
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1152

Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Ser Gln Val Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Val Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1153
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1153

Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Ser Gln Val Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Val Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1154
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1154

Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Ser Gln Val Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1155
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1155

Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Ser Gln Val Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Val Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1156
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1156

Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Ser Gln Val Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Val Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1157
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1157

Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Ser Gln Val Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Leu Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1158
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1158

Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Ser Gln Val Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Leu Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1159
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1159

Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Ser Gln Val Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Val Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1160
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1160

Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Ser Gln Phe Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1161
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1161

Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Ser Gln Phe Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Val Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1162
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1162

Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Ser Gln Phe Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Val Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1163
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1163

Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Ser Gln Phe Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Leu Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1164
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1164

Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Ser Gln Phe Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Leu Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1165
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1165

Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Ser Gln Phe Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Val Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1166
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1166

Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Ser Gln Phe Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Leu Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1167
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1167

Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Ser Gln Phe Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Leu Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1168
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1168

Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Ser Gln Phe Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Val Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1169
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1169

Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Ser Gln Phe Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Leu Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1170
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1170

Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1171
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1171

Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Val Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1172
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1172

Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Val Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1173
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1173

Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Leu Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1174
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1174

Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Leu Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1175
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1175

Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Val Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1176
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1176

Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Leu Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1177
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1177

Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Leu Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1178
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1178

Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Val Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1179
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1179

Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Leu Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1180
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1180

Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Phe Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Leu Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1181
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1181

Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Phe Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Leu Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1182
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1182

Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Phe Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Val Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1183
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1183

Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Phe Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Leu Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1184
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1184

Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Leu Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1185
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1185

Arg Val Thr Ile Ser Val Asp Asn Ser Lys Ser Gln Val Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1186
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1186

Arg Val Thr Ile Ser Val Asp Asn Ser Lys Ser Gln Val Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1187
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1187

Arg Val Thr Ile Ser Val Asp Asn Ser Lys Ser Gln Val Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Val Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1188
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1188

Arg Val Thr Ile Ser Val Asp Asn Ser Lys Ser Gln Val Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Val Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1189
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1189

Arg Val Thr Ile Ser Val Asp Asn Ser Lys Ser Gln Val Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1190
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1190

Arg Val Thr Ile Ser Val Asp Asn Ser Lys Ser Gln Val Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Val Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1191
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1191

Arg Val Thr Ile Ser Val Asp Asn Ser Lys Ser Gln Val Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Val Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1192
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1192

Arg Val Thr Ile Ser Val Asp Asn Ser Lys Ser Gln Val Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Leu Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1193
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1193

Arg Val Thr Ile Ser Val Asp Asn Ser Lys Ser Gln Val Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Leu Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1194
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1194

Arg Val Thr Ile Ser Val Asp Asn Ser Lys Ser Gln Val Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Val Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1195
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1195

Arg Val Thr Ile Ser Val Asp Asn Ser Lys Ser Gln Phe Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1196
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1196

Arg Val Thr Ile Ser Val Asp Asn Ser Lys Ser Gln Phe Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Val Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1197
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1197

Arg Val Thr Ile Ser Val Asp Asn Ser Lys Ser Gln Phe Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Val Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1198
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1198

Arg Val Thr Ile Ser Val Asp Asn Ser Lys Ser Gln Phe Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Leu Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1199
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1199

Arg Val Thr Ile Ser Val Asp Asn Ser Lys Ser Gln Phe Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Leu Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1200
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1200

Arg Val Thr Ile Ser Val Asp Asn Ser Lys Ser Gln Phe Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Val Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1201
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1201

Arg Val Thr Ile Ser Val Asp Asn Ser Lys Ser Gln Phe Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Leu Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1202
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1202

Arg Val Thr Ile Ser Val Asp Asn Ser Lys Ser Gln Phe Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Leu Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1203
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1203

Arg Val Thr Ile Ser Val Asp Asn Ser Lys Ser Gln Phe Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Val Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1204
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1204

Arg Val Thr Ile Ser Val Asp Asn Ser Lys Ser Gln Phe Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Leu Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1205
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1205

Arg Val Thr Ile Ser Val Asp Asn Ser Lys Asn Gln Val Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1206
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1206

Arg Val Thr Ile Ser Val Asp Asn Ser Lys Asn Gln Val Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Val Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1207
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1207

Arg Val Thr Ile Ser Val Asp Asn Ser Lys Asn Gln Val Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Val Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1208
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1208

Arg Val Thr Ile Ser Val Asp Asn Ser Lys Asn Gln Val Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Leu Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1209
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1209

Arg Val Thr Ile Ser Val Asp Asn Ser Lys Asn Gln Val Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Leu Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1210
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1210

Arg Val Thr Ile Ser Val Asp Asn Ser Lys Asn Gln Val Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Val Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1211
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1211

Arg Val Thr Ile Ser Val Asp Asn Ser Lys Asn Gln Val Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Leu Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1212
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1212

Arg Val Thr Ile Ser Val Asp Asn Ser Lys Asn Gln Val Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Leu Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1213
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1213

Arg Val Thr Ile Ser Val Asp Asn Ser Lys Asn Gln Val Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Val Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1214
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1214

Arg Val Thr Ile Ser Val Asp Asn Ser Lys Asn Gln Val Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Leu Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1215
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1215

Arg Val Thr Ile Ser Val Asp Asn Ser Lys Asn Gln Phe Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Leu Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1216
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1216

Arg Val Thr Ile Ser Val Asp Asn Ser Lys Asn Gln Phe Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Leu Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1217
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1217

Arg Val Thr Ile Ser Val Asp Asn Ser Lys Asn Gln Phe Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Val Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1218
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1218

Arg Val Thr Ile Ser Val Asp Asn Ser Lys Asn Gln Phe Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Leu Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1219
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1219

Arg Val Thr Ile Ser Val Asp Asn Ser Lys Asn Gln Phe Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Leu Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1220
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1220

Arg Val Thr Ile Ser Val Asp Thr Ser Lys Ser Gln Val Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1221
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1221

Arg Val Thr Ile Ser Val Asp Thr Ser Lys Ser Gln Val Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Val Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1222
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1222

Arg Val Thr Ile Ser Val Asp Thr Ser Lys Ser Gln Val Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Val Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1223
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1223

Arg Val Thr Ile Ser Val Asp Thr Ser Lys Ser Gln Val Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Leu Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1224
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1224

Arg Val Thr Ile Ser Val Asp Thr Ser Lys Ser Gln Val Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Leu Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1225
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1225

Arg Val Thr Ile Ser Val Asp Thr Ser Lys Ser Gln Val Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Val Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1226
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1226

Arg Val Thr Ile Ser Val Asp Thr Ser Lys Ser Gln Val Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Leu Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1227
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1227

Arg Val Thr Ile Ser Val Asp Thr Ser Lys Ser Gln Val Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Leu Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1228
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1228

Arg Val Thr Ile Ser Val Asp Thr Ser Lys Ser Gln Val Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Val Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1229
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1229

Arg Val Thr Ile Ser Val Asp Thr Ser Lys Ser Gln Val Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Leu Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1230
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1230

Arg Val Thr Ile Ser Val Asp Thr Ser Lys Ser Gln Phe Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Leu Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1231
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1231

Arg Val Thr Ile Ser Val Asp Thr Ser Lys Ser Gln Phe Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Leu Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1232
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1232

Arg Val Thr Ile Ser Val Asp Thr Ser Lys Ser Gln Phe Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Val Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1233
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1233

Arg Val Thr Ile Ser Val Asp Thr Ser Lys Ser Gln Phe Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Leu Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1234
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1234

Arg Val Thr Ile Ser Val Asp Thr Ser Lys Ser Gln Phe Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Leu Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1235
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1235

Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Val Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Leu Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1236
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1236

Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Val Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Leu Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1237
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1237

Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Val Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Val Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1238
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1238

Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Val Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Leu Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1239
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1239

Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Val Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Leu Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1240
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1240

Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Leu Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1241
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1241

Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1242
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1242

Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1243
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1243

Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1244
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1244

Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Val Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1245
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1245

Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Val Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1246
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1246

Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Ser Gln Phe Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1247
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1247

Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Ser Gln Phe Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1248
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1248

Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Ser Gln Phe Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Val Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1249
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1249

Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Ser Gln Phe Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Val Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1250
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1250

Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Ser Gln Phe Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1251
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1251

Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Ser Gln Phe Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Val Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1252
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1252

Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Ser Gln Phe Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Val Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1253
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1253

Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Ser Gln Phe Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Leu Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1254
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1254

Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Ser Gln Phe Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Leu Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1255
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1255

Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Ser Gln Phe Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Val Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1256
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1256

Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Val Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1257
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1257

Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Val Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1258
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1258

Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Val Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Val Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1259
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1259

Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Val Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Val Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1260
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1260

Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Val Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1261
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1261

Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Val Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Val Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1262
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1262

Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Val Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Val Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1263
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1263

Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Val Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Leu Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1264
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1264

Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Val Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Leu Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1265
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1265

Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Val Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Val Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1266
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1266

Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Phe Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1267
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1267

Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Phe Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Val Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1268
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1268

Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Phe Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Val Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1269
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1269

Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Phe Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Leu Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1270
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1270

Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Phe Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Leu Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1271
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1271

Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Phe Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Val Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1272
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1272

Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Phe Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Leu Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1273
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1273

Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Phe Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Leu Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1274
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1274

Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Phe Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Val Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1275
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1275

Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Phe Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Leu Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1276
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1276

Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Ser Gln Val Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1277
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1277

Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Ser Gln Val Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1278
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1278

Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Ser Gln Val Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Val Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1279
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1279

Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Ser Gln Val Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Val Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1280
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1280

Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Ser Gln Val Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1281
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1281

Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Ser Gln Val Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Val Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1282
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1282

Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Ser Gln Val Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Val Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1283
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1283

Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Ser Gln Val Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Leu Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1284
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1284

Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Ser Gln Val Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Leu Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1285
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1285

Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Ser Gln Val Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Val Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1286
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1286

Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Ser Gln Phe Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1287
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1287

Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Ser Gln Phe Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Val Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1288
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1288

Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Ser Gln Phe Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Val Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1289
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1289

Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Ser Gln Phe Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Leu Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1290
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1290

Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Ser Gln Phe Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Leu Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1291
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1291

Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Ser Gln Phe Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Val Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1292
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1292

Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Ser Gln Phe Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Leu Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1293
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1293

Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Ser Gln Phe Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Leu Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1294
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1294

Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Ser Gln Phe Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Val Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1295
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1295

Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Ser Gln Phe Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Leu Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1296
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1296

Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1297
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1297

Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Val Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1298
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1298

Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Val Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1299
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1299

Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Leu Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1300
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1300

Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Leu Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1301
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1301

Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Val Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1302
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1302

Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Leu Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1303
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1303

Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Leu Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1304
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1304

Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Val Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1305
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1305

Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Leu Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1306
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1306

Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Phe Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Leu Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1307
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1307

Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Phe Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Leu Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1308
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1308

Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Phe Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Val Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1309
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1309

Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Phe Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Leu Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1310
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1310

Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Leu Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1311
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1311

Arg Leu Thr Ile Ser Val Asp Asn Ser Lys Ser Gln Val Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1312
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1312

Arg Leu Thr Ile Ser Val Asp Asn Ser Lys Ser Gln Val Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1313
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1313

Arg Leu Thr Ile Ser Val Asp Asn Ser Lys Ser Gln Val Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Val Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1314
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1314

Arg Leu Thr Ile Ser Val Asp Asn Ser Lys Ser Gln Val Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Val Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1315
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1315

Arg Leu Thr Ile Ser Val Asp Asn Ser Lys Ser Gln Val Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1316
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1316

Arg Leu Thr Ile Ser Val Asp Asn Ser Lys Ser Gln Val Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Val Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1317
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1317

Arg Leu Thr Ile Ser Val Asp Asn Ser Lys Ser Gln Val Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Val Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1318
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1318

Arg Leu Thr Ile Ser Val Asp Asn Ser Lys Ser Gln Val Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Leu Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1319
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1319

Arg Leu Thr Ile Ser Val Asp Asn Ser Lys Ser Gln Val Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Leu Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1320
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1320

Arg Leu Thr Ile Ser Val Asp Asn Ser Lys Ser Gln Val Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Val Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1321
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1321

Arg Leu Thr Ile Ser Val Asp Asn Ser Lys Ser Gln Phe Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1322
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1322

Arg Leu Thr Ile Ser Val Asp Asn Ser Lys Ser Gln Phe Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Val Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1323
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1323

Arg Leu Thr Ile Ser Val Asp Asn Ser Lys Ser Gln Phe Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Val Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1324
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1324

Arg Leu Thr Ile Ser Val Asp Asn Ser Lys Ser Gln Phe Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Leu Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1325
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1325

Arg Leu Thr Ile Ser Val Asp Asn Ser Lys Ser Gln Phe Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Leu Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1326
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1326

Arg Leu Thr Ile Ser Val Asp Asn Ser Lys Ser Gln Phe Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Val Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1327
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1327

Arg Leu Thr Ile Ser Val Asp Asn Ser Lys Ser Gln Phe Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Leu Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1328
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1328

Arg Leu Thr Ile Ser Val Asp Asn Ser Lys Ser Gln Phe Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Leu Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1329
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1329

Arg Leu Thr Ile Ser Val Asp Asn Ser Lys Ser Gln Phe Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Val Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1330
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1330

Arg Leu Thr Ile Ser Val Asp Asn Ser Lys Ser Gln Phe Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Leu Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1331
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1331

Arg Leu Thr Ile Ser Val Asp Asn Ser Lys Asn Gln Val Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1332
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1332

Arg Leu Thr Ile Ser Val Asp Asn Ser Lys Asn Gln Val Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Val Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1333
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1333

Arg Leu Thr Ile Ser Val Asp Asn Ser Lys Asn Gln Val Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Val Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1334
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1334

Arg Leu Thr Ile Ser Val Asp Asn Ser Lys Asn Gln Val Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Leu Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1335
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1335

Arg Leu Thr Ile Ser Val Asp Asn Ser Lys Asn Gln Val Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Leu Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1336
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1336

Arg Leu Thr Ile Ser Val Asp Asn Ser Lys Asn Gln Val Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Val Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1337
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1337

Arg Leu Thr Ile Ser Val Asp Asn Ser Lys Asn Gln Val Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Leu Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1338
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1338

Arg Leu Thr Ile Ser Val Asp Asn Ser Lys Asn Gln Val Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Leu Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1339
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1339

Arg Leu Thr Ile Ser Val Asp Asn Ser Lys Asn Gln Val Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Val Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1340
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1340

Arg Leu Thr Ile Ser Val Asp Asn Ser Lys Asn Gln Val Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Leu Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1341
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1341

Arg Leu Thr Ile Ser Val Asp Asn Ser Lys Asn Gln Phe Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Leu Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1342
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1342

Arg Leu Thr Ile Ser Val Asp Asn Ser Lys Asn Gln Phe Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Leu Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1343
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1343

Arg Leu Thr Ile Ser Val Asp Asn Ser Lys Asn Gln Phe Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Val Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1344
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1344

Arg Leu Thr Ile Ser Val Asp Asn Ser Lys Asn Gln Phe Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Leu Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1345
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1345

Arg Leu Thr Ile Ser Val Asp Asn Ser Lys Asn Gln Phe Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Leu Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1346
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1346

Arg Leu Thr Ile Ser Val Asp Thr Ser Lys Ser Gln Val Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1347
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1347

Arg Leu Thr Ile Ser Val Asp Thr Ser Lys Ser Gln Val Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Val Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1348
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1348

Arg Leu Thr Ile Ser Val Asp Thr Ser Lys Ser Gln Val Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Val Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1349
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1349

Arg Leu Thr Ile Ser Val Asp Thr Ser Lys Ser Gln Val Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Leu Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1350
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1350

Arg Leu Thr Ile Ser Val Asp Thr Ser Lys Ser Gln Val Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Leu Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1351
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1351

Arg Leu Thr Ile Ser Val Asp Thr Ser Lys Ser Gln Val Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Val Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1352
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1352

Arg Leu Thr Ile Ser Val Asp Thr Ser Lys Ser Gln Val Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Leu Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1353
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1353

Arg Leu Thr Ile Ser Val Asp Thr Ser Lys Ser Gln Val Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Leu Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1354
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1354

Arg Leu Thr Ile Ser Val Asp Thr Ser Lys Ser Gln Val Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Val Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1355
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1355

Arg Leu Thr Ile Ser Val Asp Thr Ser Lys Ser Gln Val Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Leu Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1356
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1356

Arg Leu Thr Ile Ser Val Asp Thr Ser Lys Ser Gln Phe Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Leu Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1357
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1357

Arg Leu Thr Ile Ser Val Asp Thr Ser Lys Ser Gln Phe Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Leu Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1358
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1358

Arg Leu Thr Ile Ser Val Asp Thr Ser Lys Ser Gln Phe Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Val Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1359
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1359

Arg Leu Thr Ile Ser Val Asp Thr Ser Lys Ser Gln Phe Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Leu Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1360
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1360

Arg Leu Thr Ile Ser Val Asp Thr Ser Lys Ser Gln Phe Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Leu Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1361
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1361

Arg Leu Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Val Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Leu Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1362
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1362

Arg Leu Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Val Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Leu Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1363
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1363

Arg Leu Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Val Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Val Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1364
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1364

Arg Leu Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Val Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Leu Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1365
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1365

Arg Leu Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Val Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Leu Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1366
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1366

Arg Leu Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Leu Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1367
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1367

Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1368
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1368

Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1369
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1369

Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Val Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1370
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1370

Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Val Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1371
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1371

Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1372
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1372

Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Val Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1373
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1373

Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Val Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1374
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1374

Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Leu Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1375
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1375

Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Leu Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1376
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1376

Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Val Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1377
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1377

Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Ser Gln Phe Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1378
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1378

Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Ser Gln Phe Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Val Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1379
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1379

Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Ser Gln Phe Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Val Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1380
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1380

Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Ser Gln Phe Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Leu Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1381
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1381

Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Ser Gln Phe Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Leu Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1382
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1382

Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Ser Gln Phe Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Val Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1383
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1383

Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Ser Gln Phe Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Leu Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1384
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1384

Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Ser Gln Phe Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Leu Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1385
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1385

Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Ser Gln Phe Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Val Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1386
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1386

Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Ser Gln Phe Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Leu Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1387
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1387

Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Val Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1388
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1388

Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Val Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Val Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1389
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1389

Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Val Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Val Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1390
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1390

Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Val Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Leu Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1391
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1391

Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Val Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Leu Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1392
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1392

Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Val Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Val Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1393
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1393

Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Val Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Leu Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1394
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1394

Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Val Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Leu Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1395
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1395

Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Val Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Val Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1396
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1396

Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Val Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Leu Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1397
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1397

Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Phe Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Leu Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1398
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1398

Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Phe Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Leu Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1399
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1399

Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Phe Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Val Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1400
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1400

Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Phe Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Leu Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1401
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1401

Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Phe Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Leu Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1402
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1402

Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Ser Gln Val Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1403
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1403

Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Ser Gln Val Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Val Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1404
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1404

Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Ser Gln Val Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Val Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1405
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1405

Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Ser Gln Val Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Leu Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1406
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1406

Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Ser Gln Val Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Leu Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1407
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1407

Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Ser Gln Val Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Val Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1408
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1408

Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Ser Gln Val Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Leu Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1409
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1409

Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Ser Gln Val Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Leu Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1410
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1410

Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Ser Gln Val Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Val Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1411
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1411

Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Ser Gln Val Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Leu Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1412
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1412

Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Ser Gln Phe Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Leu Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1413
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1413

Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Ser Gln Phe Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Leu Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1414
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1414

Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Ser Gln Phe Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Val Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1415
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1415

Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Ser Gln Phe Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Leu Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1416
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1416

Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Ser Gln Phe Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Leu Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1417
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1417

Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Leu Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1418
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1418

Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Leu Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1419
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1419

Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Val Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1420
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1420

Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Leu Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1421
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1421

Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Leu Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1422
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1422

Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Phe Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Leu Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1423
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1423

Arg Val Thr Ile Ser Val Asp Asn Ser Lys Ser Gln Val Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1424
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1424

Arg Val Thr Ile Ser Val Asp Asn Ser Lys Ser Gln Val Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Val Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1425
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1425

Arg Val Thr Ile Ser Val Asp Asn Ser Lys Ser Gln Val Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Val Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1426
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1426

Arg Val Thr Ile Ser Val Asp Asn Ser Lys Ser Gln Val Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Leu Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1427
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1427

Arg Val Thr Ile Ser Val Asp Asn Ser Lys Ser Gln Val Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Leu Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1428
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1428

Arg Val Thr Ile Ser Val Asp Asn Ser Lys Ser Gln Val Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Val Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1429
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1429

Arg Val Thr Ile Ser Val Asp Asn Ser Lys Ser Gln Val Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Leu Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1430
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1430

Arg Val Thr Ile Ser Val Asp Asn Ser Lys Ser Gln Val Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Leu Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1431
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1431

Arg Val Thr Ile Ser Val Asp Asn Ser Lys Ser Gln Val Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Val Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1432
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1432

Arg Val Thr Ile Ser Val Asp Asn Ser Lys Ser Gln Val Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Leu Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1433
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1433

Arg Val Thr Ile Ser Val Asp Asn Ser Lys Ser Gln Phe Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Leu Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1434
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1434

Arg Val Thr Ile Ser Val Asp Asn Ser Lys Ser Gln Phe Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Leu Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1435
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1435

Arg Val Thr Ile Ser Val Asp Asn Ser Lys Ser Gln Phe Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Val Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1436
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1436

Arg Val Thr Ile Ser Val Asp Asn Ser Lys Ser Gln Phe Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Leu Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1437
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1437

Arg Val Thr Ile Ser Val Asp Asn Ser Lys Ser Gln Phe Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Leu Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1438
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1438

Arg Val Thr Ile Ser Val Asp Asn Ser Lys Asn Gln Val Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Leu Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1439
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1439

Arg Val Thr Ile Ser Val Asp Asn Ser Lys Asn Gln Val Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Leu Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1440
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1440

Arg Val Thr Ile Ser Val Asp Asn Ser Lys Asn Gln Val Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Val Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1441
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1441

Arg Val Thr Ile Ser Val Asp Asn Ser Lys Asn Gln Val Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Leu Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1442
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1442

Arg Val Thr Ile Ser Val Asp Asn Ser Lys Asn Gln Val Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Leu Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1443
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1443

Arg Val Thr Ile Ser Val Asp Asn Ser Lys Asn Gln Phe Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Leu Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1444
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1444

Arg Val Thr Ile Ser Val Asp Thr Ser Lys Ser Gln Val Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Leu Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1445
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1445

Arg Val Thr Ile Ser Val Asp Thr Ser Lys Ser Gln Val Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Leu Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1446
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1446

Arg Val Thr Ile Ser Val Asp Thr Ser Lys Ser Gln Val Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Val Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1447
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1447

Arg Val Thr Ile Ser Val Asp Thr Ser Lys Ser Gln Val Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Leu Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1448
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1448

Arg Val Thr Ile Ser Val Asp Thr Ser Lys Ser Gln Val Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Leu Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1449
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1449

Arg Val Thr Ile Ser Val Asp Thr Ser Lys Ser Gln Phe Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Leu Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1450
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1450

Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Val Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Leu Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1451
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1451

Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1452
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1452

Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1453
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1453

Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Val Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1454
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1454

Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Val Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1455
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1455

Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1456
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1456

Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Val Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1457
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1457

Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Val Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1458
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1458

Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Leu Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1459
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1459

Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Leu Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1460
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1460

Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Val Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1461
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1461

Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Ser Gln Phe Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1462
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1462

Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Ser Gln Phe Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Val Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1463
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1463

Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Ser Gln Phe Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Val Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1464
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1464

Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Ser Gln Phe Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Leu Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1465
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1465

Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Ser Gln Phe Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Leu Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1466
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1466

Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Ser Gln Phe Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Val Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1467
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1467

Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Ser Gln Phe Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Leu Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1468
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1468

Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Ser Gln Phe Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Leu Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1469
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1469

Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Ser Gln Phe Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Val Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1470
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1470

Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Ser Gln Phe Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Leu Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1471
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1471

Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Val Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1472
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1472

Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Val Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Val Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1473
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1473

Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Val Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Val Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1474
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1474

Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Val Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Leu Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1475
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1475

Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Val Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Leu Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1476
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1476

Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Val Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Val Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1477
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1477

Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Val Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Leu Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1478
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1478

Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Val Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Leu Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1479
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1479

Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Val Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Val Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1480
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1480

Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Val Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Leu Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1481
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1481

Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Phe Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Leu Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1482
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1482

Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Phe Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Leu Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1483
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1483

Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Phe Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Val Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1484
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1484

Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Phe Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Leu Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1485
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1485

Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Phe Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Leu Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1486
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1486

Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Ser Gln Val Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1487
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1487

Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Ser Gln Val Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Val Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1488
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1488

Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Ser Gln Val Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Val Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1489
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1489

Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Ser Gln Val Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Leu Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1490
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1490

Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Ser Gln Val Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Leu Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1491
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1491

Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Ser Gln Val Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Val Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1492
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1492

Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Ser Gln Val Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Leu Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1493
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1493

Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Ser Gln Val Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Leu Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1494
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1494

Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Ser Gln Val Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Val Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1495
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1495

Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Ser Gln Val Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Leu Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1496
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1496

Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Ser Gln Phe Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Leu Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1497
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1497

Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Ser Gln Phe Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Leu Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1498
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1498

Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Ser Gln Phe Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Val Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1499
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1499

Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Ser Gln Phe Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Leu Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1500
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1500

Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Ser Gln Phe Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Leu Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1501
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1501

Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Leu Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1502
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1502

Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Leu Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1503
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1503

Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Val Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1504
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1504

Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Leu Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1505
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1505

Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Leu Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1506
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1506

Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Phe Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Leu Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1507
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1507

Arg Leu Thr Ile Ser Val Asp Asn Ser Lys Ser Gln Val Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1508
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1508

Arg Leu Thr Ile Ser Val Asp Asn Ser Lys Ser Gln Val Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Val Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1509
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1509

Arg Leu Thr Ile Ser Val Asp Asn Ser Lys Ser Gln Val Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Val Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1510
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1510

Arg Leu Thr Ile Ser Val Asp Asn Ser Lys Ser Gln Val Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Leu Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1511
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1511

Arg Leu Thr Ile Ser Val Asp Asn Ser Lys Ser Gln Val Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Leu Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1512
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1512

Arg Leu Thr Ile Ser Val Asp Asn Ser Lys Ser Gln Val Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Val Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1513
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1513

Arg Leu Thr Ile Ser Val Asp Asn Ser Lys Ser Gln Val Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Leu Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1514
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1514

Arg Leu Thr Ile Ser Val Asp Asn Ser Lys Ser Gln Val Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Leu Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1515
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1515

Arg Leu Thr Ile Ser Val Asp Asn Ser Lys Ser Gln Val Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Val Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1516
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1516

Arg Leu Thr Ile Ser Val Asp Asn Ser Lys Ser Gln Val Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Leu Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1517
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1517

Arg Leu Thr Ile Ser Val Asp Asn Ser Lys Ser Gln Phe Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Leu Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1518
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1518

Arg Leu Thr Ile Ser Val Asp Asn Ser Lys Ser Gln Phe Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Leu Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1519
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1519

Arg Leu Thr Ile Ser Val Asp Asn Ser Lys Ser Gln Phe Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Val Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1520
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1520

Arg Leu Thr Ile Ser Val Asp Asn Ser Lys Ser Gln Phe Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Leu Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1521
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1521

Arg Leu Thr Ile Ser Val Asp Asn Ser Lys Ser Gln Phe Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Leu Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1522
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1522

Arg Leu Thr Ile Ser Val Asp Asn Ser Lys Asn Gln Val Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Leu Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1523
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1523

Arg Leu Thr Ile Ser Val Asp Asn Ser Lys Asn Gln Val Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Leu Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1524
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1524

Arg Leu Thr Ile Ser Val Asp Asn Ser Lys Asn Gln Val Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Val Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1525
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1525

Arg Leu Thr Ile Ser Val Asp Asn Ser Lys Asn Gln Val Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Leu Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1526
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1526

Arg Leu Thr Ile Ser Val Asp Asn Ser Lys Asn Gln Val Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Leu Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1527
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1527

Arg Leu Thr Ile Ser Val Asp Asn Ser Lys Asn Gln Phe Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Leu Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1528
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1528

Arg Leu Thr Ile Ser Val Asp Thr Ser Lys Ser Gln Val Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Leu Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1529
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1529

Arg Leu Thr Ile Ser Val Asp Thr Ser Lys Ser Gln Val Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Leu Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1530
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1530

Arg Leu Thr Ile Ser Val Asp Thr Ser Lys Ser Gln Val Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Val Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1531
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1531

Arg Leu Thr Ile Ser Val Asp Thr Ser Lys Ser Gln Val Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Leu Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1532
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1532

Arg Leu Thr Ile Ser Val Asp Thr Ser Lys Ser Gln Val Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Leu Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1533
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1533

Arg Leu Thr Ile Ser Val Asp Thr Ser Lys Ser Gln Phe Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Leu Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1534
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1534

Arg Leu Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Val Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Leu Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1535
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1535

Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1536
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1536

Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Val Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1537
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1537

Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Val Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1538
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1538

Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Leu Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1539
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1539

Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Leu Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1540
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1540

Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Val Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1541
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1541

Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Leu Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1542
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1542

Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Leu Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1543
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1543

Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Val Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1544
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1544

Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Leu Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1545
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1545

Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Ser Gln Phe Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Leu Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1546
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1546

Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Ser Gln Phe Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Leu Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1547
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1547

Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Ser Gln Phe Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Val Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1548
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1548

Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Ser Gln Phe Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Leu Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1549
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1549

Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Ser Gln Phe Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Leu Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1550
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1550

Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Val Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Leu Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1551
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1551

Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Val Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Leu Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1552
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1552

Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Val Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Val Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1553
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1553

Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Val Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Leu Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1554
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1554

Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Val Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Leu Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1555
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1555

Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Phe Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Leu Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1556
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1556

Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Ser Gln Val Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Leu Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1557
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1557

Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Ser Gln Val Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Leu Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1558
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1558

Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Ser Gln Val Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Val Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1559
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1559

Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Ser Gln Val Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Leu Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1560
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1560

Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Ser Gln Val Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Leu Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1561
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1561

Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Ser Gln Phe Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Leu Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1562
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1562

Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Leu Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1563
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1563

Arg Val Thr Ile Ser Val Asp Asn Ser Lys Ser Gln Val Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Leu Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1564
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1564

Arg Val Thr Ile Ser Val Asp Asn Ser Lys Ser Gln Val Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Leu Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1565
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1565

Arg Val Thr Ile Ser Val Asp Asn Ser Lys Ser Gln Val Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Val Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1566
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1566

Arg Val Thr Ile Ser Val Asp Asn Ser Lys Ser Gln Val Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Leu Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1567
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1567

Arg Val Thr Ile Ser Val Asp Asn Ser Lys Ser Gln Val Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Leu Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1568
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1568

Arg Val Thr Ile Ser Val Asp Asn Ser Lys Ser Gln Phe Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Leu Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1569
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1569

Arg Val Thr Ile Ser Val Asp Asn Ser Lys Asn Gln Val Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Leu Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1570
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1570

Arg Val Thr Ile Ser Val Asp Thr Ser Lys Ser Gln Val Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Leu Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1571
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1571

Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1572
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1572

Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Val Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1573
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1573

Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Val Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1574
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1574

Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Leu Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1575
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1575

Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Leu Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1576
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1576

Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Val Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1577
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1577

Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Leu Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1578
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1578

Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Leu Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1579
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1579

Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Val Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1580
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1580

Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Leu Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1581
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1581

Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Ser Gln Phe Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Leu Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1582
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1582

Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Ser Gln Phe Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Leu Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1583
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1583

Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Ser Gln Phe Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Val Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1584
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1584

Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Ser Gln Phe Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Leu Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1585
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1585

Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Ser Gln Phe Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Leu Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1586
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1586

Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Val Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Leu Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1587
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1587

Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Val Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Leu Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1588
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1588

Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Val Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Val Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1589
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1589

Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Val Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Leu Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1590
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1590

Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Val Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Leu Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1591
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1591

Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Phe Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Leu Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1592
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1592

Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Ser Gln Val Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Leu Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1593
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1593

Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Ser Gln Val Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Leu Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1594
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1594

Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Ser Gln Val Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Val Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1595
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1595

Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Ser Gln Val Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Leu Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1596
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1596

Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Ser Gln Val Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Leu Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1597
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1597

Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Ser Gln Phe Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Leu Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1598
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1598

Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Leu Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1599
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1599

Arg Leu Thr Ile Ser Val Asp Asn Ser Lys Ser Gln Val Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Leu Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1600
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1600

Arg Leu Thr Ile Ser Val Asp Asn Ser Lys Ser Gln Val Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Leu Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1601
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1601

Arg Leu Thr Ile Ser Val Asp Asn Ser Lys Ser Gln Val Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Val Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1602
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1602

Arg Leu Thr Ile Ser Val Asp Asn Ser Lys Ser Gln Val Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Leu Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1603
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1603

Arg Leu Thr Ile Ser Val Asp Asn Ser Lys Ser Gln Val Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Leu Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1604
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1604

Arg Leu Thr Ile Ser Val Asp Asn Ser Lys Ser Gln Phe Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Leu Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1605
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1605

Arg Leu Thr Ile Ser Val Asp Asn Ser Lys Asn Gln Val Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Leu Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1606
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1606

Arg Leu Thr Ile Ser Val Asp Thr Ser Lys Ser Gln Val Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Leu Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1607
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1607

Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Leu Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1608
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1608

Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Leu Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1609
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1609

Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Val Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1610
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1610

Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Leu Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1611
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1611

Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Leu Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1612
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1612

Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Ser Gln Phe Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Leu Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1613
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1613

Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Val Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Leu Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1614
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1614

Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Ser Gln Val Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Leu Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1615
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1615

Arg Val Thr Ile Ser Val Asp Asn Ser Lys Ser Gln Val Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Leu Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1616
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1616

Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Leu Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1617
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1617

Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Leu Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1618
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1618

Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Val Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1619
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1619

Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Leu Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1620
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1620

Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Ser Leu Lys 
1               5                   10                  15      


Met Ser Ser Leu Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1621
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1621

Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Ser Gln Phe Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Leu Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1622
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1622

Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Val Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Leu Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1623
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1623

Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Ser Gln Val Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Leu Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1624
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1624

Arg Leu Thr Ile Ser Val Asp Asn Ser Lys Ser Gln Val Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Leu Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1625
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1625

Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Leu Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1626
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1626

Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Ser Phe Lys 
1               5                   10                  15      


Met Ser Ser Leu Gln Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1627
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1627

Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1628
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1628

Arg Leu Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1629
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1629

Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Ser Gln Phe Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1630
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1630

Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Val Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1631
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1631

Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Phe Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1632
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1632

Arg Leu Thr Ile Ser Arg Asp Thr Ser Lys Ser Gln Phe Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1633
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1633

Arg Leu Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Val Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1634
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1634

Arg Leu Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Phe Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1635
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1635

Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Ser Gln Val Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1636
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1636

Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Ser Gln Phe Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1637
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1637

Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Val Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1638
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1638

Arg Leu Thr Ile Ser Arg Asp Thr Ser Lys Ser Gln Val Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1639
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1639

Arg Leu Thr Ile Ser Arg Asp Thr Ser Lys Ser Gln Phe Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1640
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1640

Arg Leu Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Val Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1641
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1641

Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Ser Gln Val Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1642
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1642

Arg Leu Thr Ile Ser Arg Asp Thr Ser Lys Ser Gln Val Ser Phe Lys 
1               5                   10                  15      


Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1643
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3) (e.g. clones humanized 3P10, 5F12, 25M22, 
       17J16)

<400>  1643

Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr Met Glu 
1               5                   10                  15      


Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1644
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1644

Arg Phe Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr Met Glu 
1               5                   10                  15      


Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1645
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1645

Arg Val Thr Phe Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr Met Glu 
1               5                   10                  15      


Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1646
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1646

Arg Val Thr Ile Thr Leu Asp Glu Ser Thr Ser Thr Ala Tyr Met Glu 
1               5                   10                  15      


Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1647
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1647

Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr Met Glu 
1               5                   10                  15      


Leu Ser Asn Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1648
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1648

Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr Met Glu 
1               5                   10                  15      


Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Phe Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1649
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1649

Arg Phe Thr Phe Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr Met Glu 
1               5                   10                  15      


Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1650
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1650

Arg Phe Thr Ile Thr Leu Asp Glu Ser Thr Ser Thr Ala Tyr Met Glu 
1               5                   10                  15      


Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1651
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1651

Arg Phe Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr Met Glu 
1               5                   10                  15      


Leu Ser Asn Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1652
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1652

Arg Phe Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr Met Glu 
1               5                   10                  15      


Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Phe Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1653
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1653

Arg Val Thr Phe Thr Leu Asp Glu Ser Thr Ser Thr Ala Tyr Met Glu 
1               5                   10                  15      


Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1654
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1654

Arg Val Thr Phe Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr Met Glu 
1               5                   10                  15      


Leu Ser Asn Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1655
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1655

Arg Val Thr Phe Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr Met Glu 
1               5                   10                  15      


Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Phe Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1656
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1656

Arg Val Thr Ile Thr Leu Asp Glu Ser Thr Ser Thr Ala Tyr Met Glu 
1               5                   10                  15      


Leu Ser Asn Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1657
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1657

Arg Val Thr Ile Thr Leu Asp Glu Ser Thr Ser Thr Ala Tyr Met Glu 
1               5                   10                  15      


Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Phe Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1658
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1658

Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr Met Glu 
1               5                   10                  15      


Leu Ser Asn Leu Arg Ser Glu Asp Thr Ala Val Phe Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1659
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1659

Arg Phe Thr Phe Thr Leu Asp Glu Ser Thr Ser Thr Ala Tyr Met Glu 
1               5                   10                  15      


Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1660
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1660

Arg Phe Thr Phe Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr Met Glu 
1               5                   10                  15      


Leu Ser Asn Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1661
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1661

Arg Phe Thr Phe Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr Met Glu 
1               5                   10                  15      


Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Phe Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1662
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1662

Arg Val Thr Phe Thr Leu Asp Glu Ser Thr Ser Thr Ala Tyr Met Glu 
1               5                   10                  15      


Leu Ser Asn Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1663
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1663

Arg Val Thr Phe Thr Leu Asp Glu Ser Thr Ser Thr Ala Tyr Met Glu 
1               5                   10                  15      


Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Phe Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1664
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1664

Arg Val Thr Phe Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr Met Glu 
1               5                   10                  15      


Leu Ser Asn Leu Arg Ser Glu Asp Thr Ala Val Phe Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1665
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1665

Arg Val Thr Ile Thr Leu Asp Glu Ser Thr Ser Thr Ala Tyr Met Glu 
1               5                   10                  15      


Leu Ser Asn Leu Arg Ser Glu Asp Thr Ala Val Phe Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1666
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1666

Arg Phe Thr Phe Thr Leu Asp Glu Ser Thr Ser Thr Ala Tyr Met Glu 
1               5                   10                  15      


Leu Ser Asn Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1667
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1667

Arg Phe Thr Phe Thr Leu Asp Glu Ser Thr Ser Thr Ala Tyr Met Glu 
1               5                   10                  15      


Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Phe Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1668
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1668

Arg Phe Thr Phe Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr Met Glu 
1               5                   10                  15      


Leu Ser Asn Leu Arg Ser Glu Asp Thr Ala Val Phe Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1669
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1669

Arg Val Thr Phe Thr Leu Asp Glu Ser Thr Ser Thr Ala Tyr Met Glu 
1               5                   10                  15      


Leu Ser Asn Leu Arg Ser Glu Asp Thr Ala Val Phe Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1670
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1670

Arg Phe Thr Phe Thr Leu Asp Glu Ser Thr Ser Thr Ala Tyr Met Glu 
1               5                   10                  15      


Leu Ser Asn Leu Arg Ser Glu Asp Thr Ala Val Phe Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1671
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1671

Arg Val Thr Leu Thr Ala Asp Thr Ser Thr Asp Thr Ala Tyr Met Glu 
1               5                   10                  15      


Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys Ala Arg 
            20                  25                  30          


<210>  1672
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1672

Arg Phe Thr Leu Thr Ala Asp Thr Ser Thr Asp Thr Ala Tyr Met Glu 
1               5                   10                  15      


Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys Ala Arg 
            20                  25                  30          


<210>  1673
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1673

Arg Val Thr Phe Thr Ala Asp Thr Ser Thr Asp Thr Ala Tyr Met Glu 
1               5                   10                  15      


Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys Ala Arg 
            20                  25                  30          


<210>  1674
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1674

Arg Val Thr Leu Thr Ala Asp Thr Ser Thr Asp Thr Ala Tyr Leu Glu 
1               5                   10                  15      


Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys Ala Arg 
            20                  25                  30          


<210>  1675
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1675

Arg Phe Thr Phe Thr Ala Asp Thr Ser Thr Asp Thr Ala Tyr Met Glu 
1               5                   10                  15      


Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys Ala Arg 
            20                  25                  30          


<210>  1676
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1676

Arg Phe Thr Leu Thr Ala Asp Thr Ser Thr Asp Thr Ala Tyr Leu Glu 
1               5                   10                  15      


Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys Ala Arg 
            20                  25                  30          


<210>  1677
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1677

Arg Val Thr Phe Thr Ala Asp Thr Ser Thr Asp Thr Ala Tyr Leu Glu 
1               5                   10                  15      


Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys Ala Arg 
            20                  25                  30          


<210>  1678
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1678

Arg Phe Thr Phe Thr Ala Asp Thr Ser Thr Asp Thr Ala Tyr Leu Glu 
1               5                   10                  15      


Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys Ala Arg 
            20                  25                  30          


<210>  1679
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3) (e.g. clones humanized 5F12, 25M22, 17J16)

<400>  1679

Arg Ala Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr Met Glu 
1               5                   10                  15      


Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1680
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3) (e.g. clones humanized 5F12, 25M22, 17J16)

<400>  1680

Arg Val Thr Leu Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr Met Glu 
1               5                   10                  15      


Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1681
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3) (e.g. clones humanized 5F12, 25M22)

<400>  1681

Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr Met Glu 
1               5                   10                  15      


Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1682
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3) (e.g. clones humanized 5F12, 25M22, 17J16)

<400>  1682

Arg Ala Thr Leu Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr Met Glu 
1               5                   10                  15      


Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1683
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3) (e.g. clones humanized 5F12, 25M22)

<400>  1683

Arg Ala Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr Met Glu 
1               5                   10                  15      


Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1684
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3) (e.g. clones humanized 5F12, 25M22)

<400>  1684

Arg Val Thr Leu Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr Met Glu 
1               5                   10                  15      


Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1685
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3) (e.g. clones humanized 5F12, 25M22)

<400>  1685

Arg Ala Thr Leu Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr Met Glu 
1               5                   10                  15      


Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1686
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3) (e.g. clone humanized 17J16)

<400>  1686

Arg Ala Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr Met Glu 
1               5                   10                  15      


Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1687
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3) (e.g. clone humanized 17J16)

<400>  1687

Arg Val Thr Ile Thr Ala Asp Glu Ser Ser Ser Thr Ala Tyr Met Glu 
1               5                   10                  15      


Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1688
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3) (e.g. clone humanized 17J16)

<400>  1688

Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr Leu Glu 
1               5                   10                  15      


Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1689
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3) (e.g. clone humanized 17J16)

<400>  1689

Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr Met Glu 
1               5                   10                  15      


Leu Ser Arg Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1690
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3) (e.g. clone humanized 17J16)

<400>  1690

Arg Ala Thr Ile Thr Ala Asp Glu Ser Ser Ser Thr Ala Tyr Met Glu 
1               5                   10                  15      


Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1691
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3) (e.g. clone humanized 17J16)

<400>  1691

Arg Ala Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr Leu Glu 
1               5                   10                  15      


Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1692
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3) (e.g. clone humanized 17J16)

<400>  1692

Arg Ala Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr Met Glu 
1               5                   10                  15      


Leu Ser Arg Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1693
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3) (e.g. clone humanized 17J16)

<400>  1693

Arg Val Thr Leu Thr Ala Asp Glu Ser Ser Ser Thr Ala Tyr Met Glu 
1               5                   10                  15      


Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1694
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3) (e.g. clone humanized 17J16)

<400>  1694

Arg Val Thr Leu Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr Leu Glu 
1               5                   10                  15      


Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1695
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3) (e.g. clone humanized 17J16)

<400>  1695

Arg Val Thr Leu Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr Met Glu 
1               5                   10                  15      


Leu Ser Arg Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1696
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3) (e.g. clone humanized 17J16)

<400>  1696

Arg Val Thr Ile Thr Ala Asp Glu Ser Ser Ser Thr Ala Tyr Leu Glu 
1               5                   10                  15      


Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1697
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3) (e.g. clone humanized 17J16)

<400>  1697

Arg Val Thr Ile Thr Ala Asp Glu Ser Ser Ser Thr Ala Tyr Met Glu 
1               5                   10                  15      


Leu Ser Arg Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1698
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3) (e.g. clone humanized 17J16)

<400>  1698

Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr Leu Glu 
1               5                   10                  15      


Leu Ser Arg Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1699
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3) (e.g. clone humanized 17J16)

<400>  1699

Arg Ala Thr Leu Thr Ala Asp Glu Ser Ser Ser Thr Ala Tyr Met Glu 
1               5                   10                  15      


Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1700
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3) (e.g. clone humanized 17J16)

<400>  1700

Arg Ala Thr Leu Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr Leu Glu 
1               5                   10                  15      


Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1701
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3) (e.g. clone humanized 17J16)

<400>  1701

Arg Ala Thr Leu Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr Met Glu 
1               5                   10                  15      


Leu Ser Arg Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1702
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3) (e.g. clone humanized 17J16)

<400>  1702

Arg Ala Thr Ile Thr Ala Asp Glu Ser Ser Ser Thr Ala Tyr Leu Glu 
1               5                   10                  15      


Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1703
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3) (e.g. clone humanized 17J16)

<400>  1703

Arg Ala Thr Ile Thr Ala Asp Glu Ser Ser Ser Thr Ala Tyr Met Glu 
1               5                   10                  15      


Leu Ser Arg Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1704
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3) (e.g. clone humanized 17J16)

<400>  1704

Arg Ala Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr Leu Glu 
1               5                   10                  15      


Leu Ser Arg Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1705
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3) (e.g. clone humanized 17J16)

<400>  1705

Arg Val Thr Leu Thr Ala Asp Glu Ser Ser Ser Thr Ala Tyr Leu Glu 
1               5                   10                  15      


Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1706
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3) (e.g. clone humanized 17J16)

<400>  1706

Arg Val Thr Leu Thr Ala Asp Glu Ser Ser Ser Thr Ala Tyr Met Glu 
1               5                   10                  15      


Leu Ser Arg Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1707
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3) (e.g. clone humanized 17J16)

<400>  1707

Arg Val Thr Leu Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr Leu Glu 
1               5                   10                  15      


Leu Ser Arg Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1708
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3) (e.g. clone humanized 17J16)

<400>  1708

Arg Val Thr Ile Thr Ala Asp Glu Ser Ser Ser Thr Ala Tyr Leu Glu 
1               5                   10                  15      


Leu Ser Arg Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1709
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3) (e.g. clone humanized 17J16)

<400>  1709

Arg Ala Thr Leu Thr Ala Asp Glu Ser Ser Ser Thr Ala Tyr Leu Glu 
1               5                   10                  15      


Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1710
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3) (e.g. clone humanized 17J16)

<400>  1710

Arg Ala Thr Leu Thr Ala Asp Glu Ser Ser Ser Thr Ala Tyr Met Glu 
1               5                   10                  15      


Leu Ser Arg Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1711
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3) (e.g. clone humanized 17J16)

<400>  1711

Arg Ala Thr Leu Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr Leu Glu 
1               5                   10                  15      


Leu Ser Arg Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1712
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3) (e.g. clone humanized 17J16)

<400>  1712

Arg Ala Thr Ile Thr Ala Asp Glu Ser Ser Ser Thr Ala Tyr Leu Glu 
1               5                   10                  15      


Leu Ser Arg Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1713
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3) (e.g. clone humanized 17J16)

<400>  1713

Arg Val Thr Leu Thr Ala Asp Glu Ser Ser Ser Thr Ala Tyr Leu Glu 
1               5                   10                  15      


Leu Ser Arg Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1714
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3) (e.g. clone humanized 17J16)

<400>  1714

Arg Ala Thr Leu Thr Ala Asp Glu Ser Ser Ser Thr Ala Tyr Leu Glu 
1               5                   10                  15      


Leu Ser Arg Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1715
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1715

Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr Met Glu 
1               5                   10                  15      


Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1716
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1716

Arg Ala Thr Ile Thr Arg Asp Glu Ser Ala Ser Thr Ala Tyr Met Glu 
1               5                   10                  15      


Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1717
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1717

Arg Val Thr Leu Thr Arg Asp Glu Ser Ala Ser Thr Ala Tyr Met Glu 
1               5                   10                  15      


Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1718
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1718

Arg Val Thr Ile Thr Arg Asp Lys Ser Ala Ser Thr Ala Tyr Met Glu 
1               5                   10                  15      


Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1719
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1719

Arg Ala Thr Leu Thr Arg Asp Glu Ser Ala Ser Thr Ala Tyr Met Glu 
1               5                   10                  15      


Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1720
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1720

Arg Ala Thr Ile Thr Arg Asp Lys Ser Ala Ser Thr Ala Tyr Met Glu 
1               5                   10                  15      


Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1721
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1721

Arg Val Thr Leu Thr Arg Asp Lys Ser Ala Ser Thr Ala Tyr Met Glu 
1               5                   10                  15      


Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1722
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1722

Arg Ala Thr Leu Thr Arg Asp Lys Ser Ala Ser Thr Ala Tyr Met Glu 
1               5                   10                  15      


Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1723
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1723

Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr Leu Gln 
1               5                   10                  15      


Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1724
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1724

Gln Ala Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr Leu Gln 
1               5                   10                  15      


Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1725
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1725

Gln Val Thr Leu Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr Leu Gln 
1               5                   10                  15      


Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1726
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 3 (FR3)

<400>  1726

Gln Ala Thr Leu Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr Leu Gln 
1               5                   10                  15      


Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1727
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 4 (FR4)

<400>  1727

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  1728
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Framework 4 (FR4)

<400>  1728

Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
1               5                   10      


<210>  1729
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Framework 1 (FR1)

<400>  1729

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys 
            20              


<210>  1730
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Framework 1 (FR1)

<400>  1730

Asp Val Val Leu Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys 
            20              


<210>  1731
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Framework 1 (FR1)

<400>  1731

Asp Val Val Leu Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Asp Pro Ala Ser Ile Ser Cys 
            20              


<210>  1732
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Framework 1 (FR1)

<400>  1732

Asp Val Val Leu Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Asp Pro Ala Ser Ile Ser Cys 
            20              


<210>  1733
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Framework 1 (FR1)

<400>  1733

Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys 
            20              


<210>  1734
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Framework 1 (FR1)

<400>  1734

Asp Ile Val Leu Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys 
            20              


<210>  1735
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Framework 1 (FR1)

<400>  1735

Asp Val Ala Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys 
            20              


<210>  1736
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Framework 1 (FR1)

<400>  1736

Asp Val Ala Leu Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys 
            20              


<210>  1737
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Framework 1 (FR1)

<400>  1737

Asp Val Val Leu Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Pro Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys 
            20              


<210>  1738
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Framework 1 (FR1)

<400>  1738

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Pro Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys 
            20              


<210>  1739
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Framework 1 (FR1)

<400>  1739

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Pro Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys 
            20              


<210>  1740
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Framework 1 (FR1)

<400>  1740

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Pro Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys 
            20              


<210>  1741
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Framework 1 (FR1)

<400>  1741

Asp Ile Glu Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys 
            20              


<210>  1742
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Framework 1 (FR1)

<400>  1742

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys 
            20              


<210>  1743
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Framework 1 (FR1)

<400>  1743

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys 
            20              


<210>  1744
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Framework 1 (FR1)

<400>  1744

Asp Ile Val Leu Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys 
            20              


<210>  1745
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Framework 1 (FR1)

<400>  1745

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys 
            20              


<210>  1746
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Framework 1 (FR1)

<400>  1746

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys 
            20              


<210>  1747
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Framework 1 (FR1)

<400>  1747

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys 
            20              


<210>  1748
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Framework 1 (FR1)

<400>  1748

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys 
            20              


<210>  1749
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Framework 1 (FR1)

<400>  1749

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys 
            20              


<210>  1750
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Framework 1 (FR1)

<400>  1750

Glu Val Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys 
            20              


<210>  1751
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Framework 2 (FR2)

<400>  1751

Trp Phe Gln Gln Arg Pro Gly Gln Ser Pro Arg Arg Leu Ile Tyr 
1               5                   10                  15  


<210>  1752
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Framework 2 (FR2)

<400>  1752

Trp Tyr Gln Gln Arg Pro Gly Gln Ser Pro Arg Arg Leu Ile Tyr 
1               5                   10                  15  


<210>  1753
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Framework 2 (FR2)

<400>  1753

Trp Phe Gln Gln Lys Pro Gly Gln Ser Pro Arg Arg Leu Ile Tyr 
1               5                   10                  15  


<210>  1754
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Framework 2 (FR2)

<400>  1754

Trp Phe Gln Gln Arg Pro Gly Gln Ser Pro Lys Arg Leu Ile Tyr 
1               5                   10                  15  


<210>  1755
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Framework 2 (FR2)

<400>  1755

Trp Phe Gln Gln Arg Pro Gly Gln Ser Pro Arg Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  1756
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Framework 2 (FR2)

<400>  1756

Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Arg Arg Leu Ile Tyr 
1               5                   10                  15  


<210>  1757
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Framework 2 (FR2)

<400>  1757

Trp Tyr Gln Gln Arg Pro Gly Gln Ser Pro Lys Arg Leu Ile Tyr 
1               5                   10                  15  


<210>  1758
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Framework 2 (FR2)

<400>  1758

Trp Tyr Gln Gln Arg Pro Gly Gln Ser Pro Arg Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  1759
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Framework 2 (FR2)

<400>  1759

Trp Phe Gln Gln Lys Pro Gly Gln Ser Pro Lys Arg Leu Ile Tyr 
1               5                   10                  15  


<210>  1760
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Framework 2 (FR2)

<400>  1760

Trp Phe Gln Gln Lys Pro Gly Gln Ser Pro Arg Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  1761
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Framework 2 (FR2)

<400>  1761

Trp Phe Gln Gln Arg Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  1762
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Framework 2 (FR2)

<400>  1762

Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Arg Leu Ile Tyr 
1               5                   10                  15  


<210>  1763
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Framework 2 (FR2)

<400>  1763

Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Arg Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  1764
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Framework 2 (FR2)

<400>  1764

Trp Tyr Gln Gln Arg Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  1765
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Framework 2 (FR2)

<400>  1765

Trp Phe Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  1766
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Framework 2 (FR2)

<400>  1766

Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  1767
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Framework 2 (FR2)

<400>  1767

Trp Leu Gln Gln Arg Pro Gly Gln Ser Pro Arg Arg Leu Ile Tyr 
1               5                   10                  15  


<210>  1768
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Framework 2 (FR2)

<400>  1768

Trp Leu Gln Gln Arg Pro Gly Gln Ser Pro Lys Arg Leu Ile Tyr 
1               5                   10                  15  


<210>  1769
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Framework 2 (FR2)

<400>  1769

Trp Phe Gln Gln Arg Pro Gly Gln Ser Pro Arg Arg Leu Ile Phe 
1               5                   10                  15  


<210>  1770
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Framework 2 (FR2)

<400>  1770

Trp Tyr Gln Gln Arg Pro Gly Gln Ser Pro Arg Arg Leu Ile Phe 
1               5                   10                  15  


<210>  1771
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Framework 2 (FR2)

<400>  1771

Trp Phe Gln Gln Arg Pro Gly Gln Ser Pro Arg Leu Leu Ile Phe 
1               5                   10                  15  


<210>  1772
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Framework 2 (FR2)

<400>  1772

Trp Tyr Gln Gln Arg Pro Gly Gln Ser Pro Arg Leu Leu Ile Phe 
1               5                   10                  15  


<210>  1773
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Framework 2 (FR2)

<400>  1773

Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  1774
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Framework 2 (FR2)

<400>  1774

Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  1775
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Framework 2 (FR2)

<400>  1775

Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  1776
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Framework 2 (FR2)

<400>  1776

Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  1777
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Framework 2 (FR2)

<400>  1777

Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Phe 
1               5                   10                  15  


<210>  1778
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Framework 3 (FR3)

<400>  1778

Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys 
            20                  25                  30          


<210>  1779
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Framework 3 (FR3)

<400>  1779

Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Ala Asp Phe Thr 
1               5                   10                  15      


Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys 
            20                  25                  30          


<210>  1780
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Framework 3 (FR3)

<400>  1780

Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Phe Cys 
            20                  25                  30          


<210>  1781
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Framework 3 (FR3)

<400>  1781

Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr 
1               5                   10                  15      


Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys 
            20                  25                  30          


<210>  1782
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Framework 3 (FR3)

<400>  1782

Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys 
            20                  25                  30          


<210>  1783
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Framework 3 (FR3)

<400>  1783

Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys 
            20                  25                  30          


<210>  1784
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Framework 3 (FR3)

<400>  1784

Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ser Val Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys 
            20                  25                  30          


<210>  1785
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Framework 3 (FR3)

<400>  1785

Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ser Val Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys 
            20                  25                  30          


<210>  1786
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Framework 3 (FR3)

<400>  1786

Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  1787
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Framework 3 (FR3)

<400>  1787

Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ser Val Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  1788
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Framework 3 (FR3)

<400>  1788

Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys 
            20                  25                  30          


<210>  1789
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Framework 3 (FR3)

<400>  1789

Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys 
            20                  25                  30          


<210>  1790
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Framework 3 (FR3)

<400>  1790

Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ser Val Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys 
            20                  25                  30          


<210>  1791
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Framework 3 (FR3)

<400>  1791

Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ser Val Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys 
            20                  25                  30          


<210>  1792
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Framework 3 (FR3)

<400>  1792

Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys 
            20                  25                  30          


<210>  1793
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Framework 4 (FR4)

<400>  1793

Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
1               5                   10  


<210>  1794
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Framework 4 (FR4)

<400>  1794

Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
1               5                   10  


<210>  1795
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 1795

Gly Phe Thr Phe Thr Asp Tyr Tyr 
1               5               


<210>  1796
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400> 1796

Gly Phe Thr Phe Thr Asp Tyr 
1               5           


<210>  1797
<211>  394
<212>  PRT
<213>  Homo sapiens

<220>
<223>  full-length precursor human GFRAL with signal peptide sequence

<400>  1797

Met Ile Val Phe Ile Phe Leu Ala Met Gly Leu Ser Leu Glu Asn Glu 
1               5                   10                  15      


Tyr Thr Ser Gln Thr Asn Asn Cys Thr Tyr Leu Arg Glu Gln Cys Leu 
            20                  25                  30          


Arg Asp Ala Asn Gly Cys Lys His Ala Trp Arg Val Met Glu Asp Ala 
        35                  40                  45              


Cys Asn Asp Ser Asp Pro Gly Asp Pro Cys Lys Met Arg Asn Ser Ser 
    50                  55                  60                  


Tyr Cys Asn Leu Ser Ile Gln Tyr Leu Val Glu Ser Asn Phe Gln Phe 
65                  70                  75                  80  


Lys Glu Cys Leu Cys Thr Asp Asp Phe Tyr Cys Thr Val Asn Lys Leu 
                85                  90                  95      


Leu Gly Lys Lys Cys Ile Asn Lys Ser Asp Asn Val Lys Glu Asp Lys 
            100                 105                 110         


Phe Lys Trp Asn Leu Thr Thr Arg Ser His His Gly Phe Lys Gly Met 
        115                 120                 125             


Trp Ser Cys Leu Glu Val Ala Glu Ala Cys Val Gly Asp Val Val Cys 
    130                 135                 140                 


Asn Ala Gln Leu Ala Ser Tyr Leu Lys Ala Cys Ser Ala Asn Gly Asn 
145                 150                 155                 160 


Pro Cys Asp Leu Lys Gln Cys Gln Ala Ala Ile Arg Phe Phe Tyr Gln 
                165                 170                 175     


Asn Ile Pro Phe Asn Ile Ala Gln Met Leu Ala Phe Cys Asp Cys Ala 
            180                 185                 190         


Gln Ser Asp Ile Pro Cys Gln Gln Ser Lys Glu Ala Leu His Ser Lys 
        195                 200                 205             


Thr Cys Ala Val Asn Met Val Pro Pro Pro Thr Cys Leu Ser Val Ile 
    210                 215                 220                 


Arg Ser Cys Gln Asn Asp Glu Leu Cys Arg Arg His Tyr Arg Thr Phe 
225                 230                 235                 240 


Gln Ser Lys Cys Trp Gln Arg Val Thr Arg Lys Cys His Glu Asp Glu 
                245                 250                 255     


Asn Cys Ile Ser Thr Leu Ser Lys Gln Asp Leu Thr Cys Ser Gly Ser 
            260                 265                 270         


Asp Asp Cys Lys Ala Ala Tyr Ile Asp Ile Leu Gly Thr Val Leu Gln 
        275                 280                 285             


Val Gln Cys Thr Cys Arg Thr Ile Thr Gln Ser Glu Glu Ser Leu Cys 
    290                 295                 300                 


Lys Ile Phe Gln His Met Leu His Arg Lys Ser Cys Phe Asn Tyr Pro 
305                 310                 315                 320 


Thr Leu Ser Asn Val Lys Gly Met Ala Leu Tyr Thr Arg Lys His Ala 
                325                 330                 335     


Asn Lys Ile Thr Leu Thr Gly Phe His Ser Pro Phe Asn Gly Glu Val 
            340                 345                 350         


Ile Tyr Ala Ala Met Cys Met Thr Val Thr Cys Gly Ile Leu Leu Leu 
        355                 360                 365             


Val Met Val Lys Leu Arg Thr Ser Arg Ile Ser Ser Lys Ala Arg Asp 
    370                 375                 380                 


Pro Ser Ser Ile Gln Ile Pro Gly Glu Leu 
385                 390                 


<210>  1798
<211>  375
<212>  PRT
<213>  Homo sapiens

<220>
<223>  mature human GFRAL polypeptide

<400>  1798

Gln Thr Asn Asn Cys Thr Tyr Leu Arg Glu Gln Cys Leu Arg Asp Ala 
1               5                   10                  15      


Asn Gly Cys Lys His Ala Trp Arg Val Met Glu Asp Ala Cys Asn Asp 
            20                  25                  30          


Ser Asp Pro Gly Asp Pro Cys Lys Met Arg Asn Ser Ser Tyr Cys Asn 
        35                  40                  45              


Leu Ser Ile Gln Tyr Leu Val Glu Ser Asn Phe Gln Phe Lys Glu Cys 
    50                  55                  60                  


Leu Cys Thr Asp Asp Phe Tyr Cys Thr Val Asn Lys Leu Leu Gly Lys 
65                  70                  75                  80  


Lys Cys Ile Asn Lys Ser Asp Asn Val Lys Glu Asp Lys Phe Lys Trp 
                85                  90                  95      


Asn Leu Thr Thr Arg Ser His His Gly Phe Lys Gly Met Trp Ser Cys 
            100                 105                 110         


Leu Glu Val Ala Glu Ala Cys Val Gly Asp Val Val Cys Asn Ala Gln 
        115                 120                 125             


Leu Ala Ser Tyr Leu Lys Ala Cys Ser Ala Asn Gly Asn Pro Cys Asp 
    130                 135                 140                 


Leu Lys Gln Cys Gln Ala Ala Ile Arg Phe Phe Tyr Gln Asn Ile Pro 
145                 150                 155                 160 


Phe Asn Ile Ala Gln Met Leu Ala Phe Cys Asp Cys Ala Gln Ser Asp 
                165                 170                 175     


Ile Pro Cys Gln Gln Ser Lys Glu Ala Leu His Ser Lys Thr Cys Ala 
            180                 185                 190         


Val Asn Met Val Pro Pro Pro Thr Cys Leu Ser Val Ile Arg Ser Cys 
        195                 200                 205             


Gln Asn Asp Glu Leu Cys Arg Arg His Tyr Arg Thr Phe Gln Ser Lys 
    210                 215                 220                 


Cys Trp Gln Arg Val Thr Arg Lys Cys His Glu Asp Glu Asn Cys Ile 
225                 230                 235                 240 


Ser Thr Leu Ser Lys Gln Asp Leu Thr Cys Ser Gly Ser Asp Asp Cys 
                245                 250                 255     


Lys Ala Ala Tyr Ile Asp Ile Leu Gly Thr Val Leu Gln Val Gln Cys 
            260                 265                 270         


Thr Cys Arg Thr Ile Thr Gln Ser Glu Glu Ser Leu Cys Lys Ile Phe 
        275                 280                 285             


Gln His Met Leu His Arg Lys Ser Cys Phe Asn Tyr Pro Thr Leu Ser 
    290                 295                 300                 


Asn Val Lys Gly Met Ala Leu Tyr Thr Arg Lys His Ala Asn Lys Ile 
305                 310                 315                 320 


Thr Leu Thr Gly Phe His Ser Pro Phe Asn Gly Glu Val Ile Tyr Ala 
                325                 330                 335     


Ala Met Cys Met Thr Val Thr Cys Gly Ile Leu Leu Leu Val Met Val 
            340                 345                 350         


Lys Leu Arg Thr Ser Arg Ile Ser Ser Lys Ala Arg Asp Pro Ser Ser 
        355                 360                 365             


Ile Gln Ile Pro Gly Glu Leu 
    370                 375 


<210>  1799
<211>  1911
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid sequence encoding a precursor GFRAL polypeptide

<400>  1799
ttattctgga cagttactct taagaaagtt gtcagaagaa acgcatctgc ctttttttcc       60

aggtgaactg ccgtgagttg tccagcatga tagtgtttat tttcttggct atggggttaa      120

gcttggaaaa tgaatacact tcccaaacca ataattgcac atatttaaga gagcaatgct      180

tacgtgatgc aaatggatgt aaacatgctt ggagagtaat ggaagatgcc tgcaatgatt      240

cagatccagg tgacccctgc aagatgagga attcatcata ctgtaacctg agtatccagt      300

acttagtgga aagcaatttc caatttaaag agtgtctttg cactgatgac ttctattgta      360

ctgtgaacaa actgcttgga aaaaaatgta tcaataaatc agataacgtg aaagaggata      420

aattcaaatg gaatctaact acacgttccc atcatggatt caaagggatg tggtcctgtt      480

tggaagtggc agaggcatgt gtaggggatg tggtctgtaa tgcacagttg gcctcttacc      540

ttaaagcttg ctcagcaaat ggaaatccgt gtgatctgaa acagtgccaa gcagccatac      600

ggttcttcta tcaaaatata ccttttaaca ttgcccagat gttggctttt tgtgactgtg      660

ctcaatctga tataccttgt cagcagtcca aagaagctct tcacagcaag acatgtgcag      720

tgaacatggt tccaccccct acttgcctca gtgtaattcg cagctgccaa aatgatgaat      780

tatgcaggag gcactataga acatttcagt caaaatgctg gcagcgtgtg actagaaagt      840

gccatgaaga tgagaattgc attagcacct taagcaaaca ggacctcact tgttcaggaa      900

gtgatgactg caaagctgct tacatagata tccttgggac ggtccttcaa gtgcaatgta      960

cctgtaggac cattacacaa agtgaggaat ctttgtgtaa gattttccag cacatgcttc     1020

atagaaaatc atgtttcaat tatccaaccc tgtctaatgt caaaggcatg gcattgtata     1080

caagaaaaca tgcaaacaaa atcactttaa ctggatttca ttcccccttc aatggagaag     1140

taatctatgc tgccatgtgc atgacagtca cctgtggaat ccttctgttg gttatggtca     1200

agcttagaac ttccagaata tcaagtaaag caagagatcc ttcatcgatc caaatacctg     1260

gagaactctg attcattagg agtcatggac ctataacaat cactcttttc tctgcttttc     1320

ttctttcctc ttttcttctc tcctctcctc tcctctcttc tcctctcctc ccctcccctc     1380

tctgtttctt tttctttttc ttttcttttt tgtggcggag ttttgctctt gttgcccagg     1440

ctgcagtaca atggctcaat ctcggttcac tgcaacctct gcctccaagg ttcaagtgat     1500

tttcctgcct cagccttccc gagtagctgg gattacaggt acccgccacc acgcccagct     1560

aatttttttg tatttttagt agagatgggg ttttgccaaa ttggccaggg tggtctcaaa     1620

ctcctgacct caggtgatcc acccacctcg gcctcccaaa gtgctgggat tacaggcgtg     1680

agcaaccacg tcaagacaac aatcactttc tttaaagcaa atcctacagc tggtcaacac     1740

cctattccat ctgtcatcga gaaagaaaat gttaaaatag acttaaaaat attgctttgt     1800

tacatataat aatatggcat gatgatgtta tttttttctt aatactcaag aaaaaatata     1860

tggtggtatc ttttacaaca ctggaacaga aataaagttt cccttgaagg c              1911    


<210>  1800
<211>  394
<212>  PRT
<213>  Macaca fascicularis

<220>
<223>  GFRAL protein - Cynomolgus Monkey

<400>  1800

Met Ile Val Leu Ile Phe Leu Ala Leu Gly Leu Ser Leu Glu Asn Glu 
1               5                   10                  15      


Tyr Thr Ser Gln Thr Asn Asn Cys Thr Tyr Leu Arg Glu Gln Cys Leu 
            20                  25                  30          


His Asp Ala Asn Gly Cys Lys His Ala Trp Arg Ile Met Glu Asp Ala 
        35                  40                  45              


Cys Asn Asp Ser Asp Pro Gly Asp Pro Cys Lys Met Asn Asn Ser Ser 
    50                  55                  60                  


Tyr Cys Asn Leu Ser Ile Gln Tyr Leu Val Glu Ser Asn Phe Arg Phe 
65                  70                  75                  80  


Lys Glu Cys Leu Cys Thr Asp Asp Phe Tyr Cys Thr Val Asn Lys Leu 
                85                  90                  95      


Leu Gly Lys Glu Cys Val Asn Lys Ser Asp Asn Met Arg Glu Asp Lys 
            100                 105                 110         


Phe Lys Trp Asn Leu Thr Thr His Ser His His Gly Phe Lys Gly Met 
        115                 120                 125             


Trp Ser Cys Leu Glu Val Ala Glu Ala Cys Val Gly Asp Val Val Cys 
    130                 135                 140                 


Asn Ala Gln Leu Ala Ser Tyr Leu Lys Ala Cys Ser Ala Asn Gly Asn 
145                 150                 155                 160 


Pro Cys Asp Val Lys His Cys Gln Ala Ala Ile Arg Phe Phe Tyr Gln 
                165                 170                 175     


Asn Ile Pro Phe Asn Ile Ala Gln Met Leu Ala Phe Cys Asp Cys Ser 
            180                 185                 190         


Gln Ser Asp Ile Pro Cys Gln Gln Ser Lys Glu Ala Leu His Ser Lys 
        195                 200                 205             


Pro Cys Ala Leu Asn Met Val Pro Pro Pro Thr Cys Leu Asn Val Ile 
    210                 215                 220                 


Arg Ser Cys Gln Asn Asp Glu Leu Cys Arg Arg His Tyr Arg Thr Phe 
225                 230                 235                 240 


Gln Ser Lys Cys Trp Gln Arg Val Thr Arg Lys Cys His Glu Asp Glu 
                245                 250                 255     


Asn Cys Ile Ser Ala Leu Ser Lys Gln Asp Leu Thr Cys Ser Gly Ser 
            260                 265                 270         


Asp Asp Cys Lys Ala Ala Tyr Ile Asp Ile Leu Gly Thr Val Leu Gln 
        275                 280                 285             


Val Gln Cys Asn Cys Arg Thr Ile Thr Gln Ser Glu Glu Ser Leu Cys 
    290                 295                 300                 


Lys Ile Phe Gln His Met Leu His Arg Lys Ser Cys Phe Asn Tyr Pro 
305                 310                 315                 320 


Thr Leu Ser Asn Val Lys Ser Met Ala Leu Tyr Thr Arg Lys His Thr 
                325                 330                 335     


Asn Lys Ile Thr Leu Thr Gly Phe Gln Ser Pro Phe Asn Gly Glu Val 
            340                 345                 350         


Ile Tyr Ala Ala Met Cys Met Thr Val Thr Cys Gly Ile Leu Leu Leu 
        355                 360                 365             


Val Met Val Lys Leu Arg Thr Ser Arg Ile Ser Ser Lys Ala Arg Asp 
    370                 375                 380                 


Pro Ser Leu Ser Gln Val Pro Gly Glu Leu 
385                 390                 


<210>  1801
<211>  1476
<212>  DNA
<213>  Macaca fascicularis

<220>
<223>  encoding nucleic acid sequence of a cyno GFRAL protein

<400>  1801
acccaccaga aagaaggagc tccagacaca tctgaacgtc tgaaggaaga aactcccgac       60

acaccatctt taagaaatgt aactctcact gcgagggtat gtggcttcat tcttgaagtc      120

agggagacca agaacccacc aattgcaggc acacaagggg tccttatttt attcaggtga      180

acagctgtga gttgtccagc atgatagtgc ttattttctt ggctttgggg ctaagcttgg      240

aaaatgaata cacttcccaa accaataatt gcacatattt aagagagcaa tgcctacatg      300

atgcaaatgg atgtaaacat gcttggagaa taatggaaga tgcctgcaat gattcagatc      360

caggtgaccc ctgcaagatg aataattcat catactgtaa cctgagtatc cagtacttag      420

tggaaagcaa tttccgattt aaagagtgtc tttgcactga tgacttctat tgtactgtga      480

acaaactgct tggaaaagaa tgtgtcaata aatcagataa catgagagag gataaattca      540

aatggaatct aactacacat tcccatcatg gattcaaagg gatgtggtcc tgtttggaag      600

tggcagaggc atgtgtaggg gatgtggtct gtaatgcaca gttggcctct taccttaaag      660

cttgctcagc aaatggaaat ccgtgtgatg tgaaacactg ccaagcagcc atacggttct      720

tctatcaaaa tatacctttt aacattgccc agatgttggc tttttgtgac tgttctcaat      780

ctgatatacc ttgtcagcag tccaaagaag ctcttcacag caagccatgt gcactgaaca      840

tggttccacc ccctacttgc ctcaatgtaa ttcgcagctg ccaaaatgat gaattatgca      900

ggaggcacta tagaacattt cagtcaaaat gctggcagcg tgtgactaga aagtgccatg      960

aagatgagaa ttgcattagc gccttaagca aacaggacct cacatgttca ggaagtgatg     1020

actgcaaagc tgcttacata gatatccttg ggacagtcct tcaagtgcaa tgtaactgta     1080

ggaccattac acaaagtgag gaatctttgt gcaagatttt ccagcacatg cttcatagaa     1140

aatcatgttt caattatcca accctgtcta atgtcaaaag catggcattg tatacaagaa     1200

aacatacaaa caaaatcact ttaactggat ttcagtcccc cttcaatgga gaagtaatct     1260

atgctgccat gtgcatgaca gtcacctgtg gaatccttct cttggttatg gtcaagctta     1320

gaacttccag aatatcaagt aaagcaagag atccttcact gagccaagta cctggagaac     1380

tctgattcat taggagtcat ggacccataa caatcactcc ccttcccttc ccttcccttc     1440

ccttcccttc ccttcccttc ccttcccttc ccttcc                               1476


<210>  1802
<211>  393
<212>  PRT
<213>  Mus musculus

<220>
<223>  GFRAL protein - mouse

<400>  1802

Met Leu Val Phe Ile Phe Leu Ala Val Thr Leu Ser Ser Glu Asn Glu 
1               5                   10                  15      


Ser Ser Ser Gln Thr Asn Asp Cys Ala His Leu Ile Gln Lys Cys Leu 
            20                  25                  30          


Ile Asp Ala Asn Gly Cys Glu Gln Ser Trp Arg Ser Met Glu Asp Thr 
        35                  40                  45              


Cys Leu Thr Pro Gly Asp Ser Cys Lys Ile Asn Asn Ser Leu His Cys 
    50                  55                  60                  


Asn Leu Ser Ile Gln Ala Leu Val Glu Lys Asn Phe Gln Phe Lys Glu 
65                  70                  75                  80  


Cys Leu Cys Met Asp Asp Leu His Cys Thr Val Asn Lys Leu Phe Gly 
                85                  90                  95      


Lys Lys Cys Thr Asn Lys Thr Asp Asn Met Glu Lys Asp Asn Lys Asp 
            100                 105                 110         


Lys Trp Asn Leu Thr Thr Thr Pro Phe Tyr His Gly Phe Lys Gln Met 
        115                 120                 125             


Gln Ser Cys Leu Glu Val Thr Glu Ala Cys Val Gly Asp Val Val Cys 
    130                 135                 140                 


Asn Ala Gln Leu Ala Leu Tyr Leu Lys Ala Cys Ser Ala Asn Gly Asn 
145                 150                 155                 160 


Leu Cys Asp Val Lys His Cys Gln Ala Ala Ile Arg Phe Phe Tyr Gln 
                165                 170                 175     


Asn Met Pro Phe Asn Thr Ala Gln Met Leu Ala Phe Cys Asp Cys Ala 
            180                 185                 190         


Gln Ser Asp Ile Pro Cys Gln Gln Ser Lys Glu Thr Leu His Ser Lys 
        195                 200                 205             


Pro Cys Ala Leu Asn Ile Val Pro Pro Pro Thr Cys Leu Ser Val Ile 
    210                 215                 220                 


His Thr Cys Arg Asn Asp Glu Leu Cys Arg Thr His Tyr Arg Thr Phe 
225                 230                 235                 240 


Gln Thr Glu Cys Trp Pro His Ile Thr Gly Lys Cys His Glu Asp Glu 
                245                 250                 255     


Thr Cys Ile Ser Met Leu Gly Lys Gln Asp Leu Thr Cys Ser Gly Ser 
            260                 265                 270         


Glu Ser Cys Arg Ala Ala Phe Leu Gly Thr Phe Gly Thr Val Leu Gln 
        275                 280                 285             


Val Pro Cys Ala Cys Arg Gly Val Thr Gln Ala Glu Glu His Val Cys 
    290                 295                 300                 


Met Ile Phe Gln His Met Leu His Ser Lys Ser Cys Phe Asn Tyr Pro 
305                 310                 315                 320 


Thr Pro Asn Val Lys Asp Ile Ser Ser Tyr Glu Lys Lys Asn Ser Lys 
                325                 330                 335     


Glu Ile Thr Leu Thr Gly Phe Asn Ser Phe Phe Asn Gly Glu Leu Leu 
            340                 345                 350         


Tyr Val Val Val Cys Met Ala Val Thr Cys Gly Ile Leu Phe Leu Val 
        355                 360                 365             


Met Leu Lys Leu Arg Ile Gln Ser Glu Lys Arg Asp Pro Ser Ser Ile 
    370                 375                 380                 


Glu Ile Ala Gly Gly Val Ile Ile Gln 
385                 390             


<210>  1803
<211>  2080
<212>  DNA
<213>  Mus musculus

<220>
<223>  encoding nucleic acid sequence of a mouse GFRAL protein

<400>  1803
aacaattgaa tttgaataca attaggaaag ttcacagctc aaaacaaact ggtgaggaac       60

agctgacacc agaagctgac tctaattggc tggctcttag gaagcaaaac ctttacacag      120

aaacttcagt tgggatgttg gttggtgtca gttcatccgc ctttctccca gggagaccat      180

cttgagttgt ccaacatgct agtgttcatt ttcctggctg ttacgttaag ctcagaaaat      240

gaatcctctt cccaaacaaa tgattgtgca catttaatac agaaatgctt gattgatgca      300

aatggctgtg agcagtcatg gagatcaatg gaagacacct gccttactcc aggtgactcc      360

tgcaagataa ataattcact acattgtaac ctgagtatcc aggctttggt ggaaaaaaat      420

ttccaattta aagagtgtct ttgtatggat gacctccact gtacagtaaa caaacttttt      480

ggaaaaaagt gcaccaataa gacagataac atggaaaagg acaataaaga taaatggaat      540

ctaactacta ctcctttcta tcatggattc aaacagatgc agtcttgttt ggaggtgaca      600

gaggcgtgtg taggggatgt ggtttgtaat gcacagttgg ccctttacct taaagcatgc      660

tcagcaaatg gaaatctgtg tgatgtgaaa cactgccaag cagccatacg gttcttctat      720

caaaatatgc cttttaacac tgcccagatg ttggcttttt gtgactgtgc tcaatctgat      780

ataccctgtc agcaatccaa agaaactctt cacagcaagc catgtgcact gaatatagtt      840

ccacccccca cttgcctcag tgtaattcac acttgccgaa atgatgaatt atgcaggaca      900

cactaccgaa cattccagac agaatgctgg ccccacataa ctgggaagtg ccatgaagat      960

gagacctgca ttagcatgtt aggcaagcaa gaccttactt gttctgggag tgagagctgc     1020

agggctgcct tcctaggaac ctttgggaca gtcctgcaag taccctgtgc ttgcaggggc     1080

gttacacagg ctgaagaaca cgtgtgcatg attttccagc acatgcttca tagcaaatcg     1140

tgtttcaatt acccaactcc taatgtcaaa gacatttcct catatgaaaa aaagaattca     1200

aaagaaatta ctctgactgg attcaattct ttcttcaatg gagaactact ctatgttgtt     1260

gtgtgcatgg cagttacctg tggaattctt ttcttggtga tgctcaagtt aaggatacaa     1320

agtgaaaaaa gagatccctc atccatcgaa atagctggag gtgtcatcat tcagtgagct     1380

gcagatcact taccaaccac atgtctgtgt gactaaccaa tggaaaatta catttgccaa     1440

taacgcaatt taagatggat ttgacaatat ttagtcatta tatgtaacag tgactggtac     1500

agtaatatac cacaatgatc acagatctgt ttttgttttt gtttttaatg tttgagtaaa     1560

tacttgttgt ggtgtcataa ctagttgata acattttctt taaagacaac aggtgtcatg     1620

taaaatgtga caaatttgct ggaagactat caatccacat atcaacttct atcttatgga     1680

actaatcata attagtgtgt gcagttttct gaacaaggtt atagttttcc attaagttgg     1740

taaaattaaa atgctaagta gaatattgag tatacttgtt atttatatat tcttacttag     1800

tgtccaatca ttaaacaaat tggtaacatt gaacatattt agttagatga ctgcttatga     1860

aaataagaac tgacatctta caaattttat aatttaaata gtattgaatt ttacttttta     1920

tttggtatgt taagattcat aatatataaa gcagctacat tggttgagaa aagtcaatgg     1980

ttactccagt aatgatatac tttgtgaatt tatttatttt tgctaattaa tgatcctgaa     2040

tgtaatcatg atgaaataaa aaagacatac ttaaattgct                           2080


<210>  1804
<211>  394
<212>  PRT
<213>  Rattus norvegicus

<220>
<223>  GFRAL protein - rat

<400>  1804

Met Leu Val Phe Ile Phe Leu Ala Val Arg Leu Ser Ser Glu Asn Glu 
1               5                   10                  15      


Ser Ser Ser Gln Thr Asn Asp Cys Ala Tyr Phe Met Arg Gln Cys Leu 
            20                  25                  30          


Thr Asp Thr Asp Gly Cys Lys Gln Ser Trp Arg Ser Met Glu Asp Ala 
        35                  40                  45              


Cys Leu Val Ser Gly Asp Ser Cys Lys Ile Asn Asn Pro Leu Pro Cys 
    50                  55                  60                  


Asn Leu Ser Ile Gln Ser Leu Val Glu Lys His Phe Gln Phe Lys Gly 
65                  70                  75                  80  


Cys Leu Cys Thr Asp Asp Leu His Cys Thr Val Asn Lys Ile Phe Gly 
                85                  90                  95      


Lys Lys Cys Thr Asn Lys Thr Asp Ser Met Lys Lys Asp Asn Lys Tyr 
            100                 105                 110         


Lys Arg Asn Leu Thr Thr Pro Leu Tyr His Asp Thr Gly Phe Lys Gln 
        115                 120                 125             


Met Gln Ser Cys Leu Glu Val Thr Glu Ala Cys Val Gly Asp Val Val 
    130                 135                 140                 


Cys Asn Ala Gln Leu Ala Leu Tyr Leu Lys Ala Cys Thr Ala Asn Gly 
145                 150                 155                 160 


Asn Leu Cys Asp Val Lys His Cys Gln Ala Ala Ile Arg Phe Phe Tyr 
                165                 170                 175     


Gln Asn Met Pro Phe Asn Thr Ala Gln Met Leu Ala Phe Cys Asp Cys 
            180                 185                 190         


Ala Gln Ser Asp Ile Pro Cys Gln Gln Ser Lys Glu Thr Leu His Ser 
        195                 200                 205             


Lys Pro Cys Ala Leu Asn Val Val Pro Pro Pro Thr Cys Leu Ser Val 
    210                 215                 220                 


Ile His Thr Cys Arg Asn Asp Glu Leu Cys Arg Thr Tyr Tyr Arg Thr 
225                 230                 235                 240 


Phe Gln Thr Glu Cys Trp Pro His Val Ala Gly Lys Cys Arg Glu Asp 
                245                 250                 255     


Glu Thr Cys Ile Ser Met Leu Gly Lys Gln Asp Leu Thr Cys Ser Gly 
            260                 265                 270         


Ser Asp Ser Cys Arg Ala Ala Tyr Leu Gly Thr Phe Gly Thr Val Leu 
        275                 280                 285             


Gln Val Pro Cys Ala Cys Arg Ser Ile Thr Gln Gly Glu Glu Pro Leu 
    290                 295                 300                 


Cys Met Ala Phe Gln His Met Leu His Ser Lys Ser Cys Phe Asn Tyr 
305                 310                 315                 320 


Pro Thr Pro Asn Val Lys Asp Ile Ser Ser Tyr Glu Arg Lys His Ser 
                325                 330                 335     


Lys Glu Ile Thr Leu Thr Gly Phe Asn Ser Pro Phe Ser Gly Glu Leu 
            340                 345                 350         


Ile Tyr Val Val Val Cys Met Val Val Thr Ser Gly Ile Leu Ser Leu 
        355                 360                 365             


Val Met Leu Lys Leu Arg Ile Pro Ser Lys Lys Arg Asp Pro Ala Pro 
    370                 375                 380                 


Ile Glu Ile Ala Gly Ala Val Ile Ile Gln 
385                 390                 


<210>  1805
<211>  1125
<212>  DNA
<213>  Rattus norvegicus

<220>
<223>  encoding nucleic acid sequence of a rat GFRAL protein

<400>  1805
acaaatgatt gtgcatattt catgcggcaa tgcttgactg atacagatgg ctgtaagcag       60

tcatggagat caatggaaga cgcctgcctt gtctcaggtg actcctgcaa gataaataat      120

ccattgcctt gtaacctgag tatccagtct ttggtggaaa aacattttca atttaaaggg      180

tgtctttgca ctgatgatct ccactgtaca gtaaacaaaa tttttggaaa aaagtgcacc      240

aataagacag atagcatgaa aaaagataat aaatacaaac ggaatctaac tactccttta      300

tatcatgata caggattcaa acagatgcag tcttgtttgg aagtgacaga ggcgtgtgta      360

ggggatgtgg tttgtaatgc acagttggcc ctttacctta aagcatgcac agcaaatgga      420

aatctgtgtg atgtgaaaca ctgccaagcg gccatacggt tcttctatca aaatatgcct      480

tttaacactg cccagatgtt ggctttttgt gactgtgctc aatctgatat accctgtcaa      540

caatccaaag aaactcttca cagcaagcca tgtgcactga acgtagttcc accccccact      600

tgcctcagtg taattcacac ttgccgaaat gatgaattat gcaggacata ctaccgaaca      660

ttccagacag aatgctggcc ccatgtggct gggaagtgtc gtgaagatga gacctgcatt      720

agtatgctgg gcaagcaaga ccttacttgt tctgggagtg acagctgcag ggcagcctac      780

ctaggaacct tcgggacagt ccttcaggtg ccgtgtgctt gcagaagcat cacacagggt      840

gaagaaccct tgtgcatggc tttccagcac atgcttcaca gcaaatcatg tttcaattac      900

ccaactccta atgtcaaaga catttcctca tatgaaagaa agcattcaaa agaaattacc      960

ctgactggat tcaattctcc cttcagtgga gaactaatct atgttgttgt gtgcatggta     1020

gttaccagcg ggattctttc cttggtgatg ctcaagctaa ggatacctag taagaaaaga     1080

gaccccgcgc ccatcgaaat agctggagct gtcatcattc agtga                     1125


<210>  1806
<211>  332
<212>  PRT
<213>  Homo sapiens

<220>
<223>  GFRAL ECD fragment

<400>  1806

Gln Thr Asn Asn Cys Thr Tyr Leu Arg Glu Gln Cys Leu Arg Asp Ala 
1               5                   10                  15      


Asn Gly Cys Lys His Ala Trp Arg Val Met Glu Asp Ala Cys Asn Asp 
            20                  25                  30          


Ser Asp Pro Gly Asp Pro Cys Lys Met Arg Asn Ser Ser Tyr Cys Asn 
        35                  40                  45              


Leu Ser Ile Gln Tyr Leu Val Glu Ser Asn Phe Gln Phe Lys Glu Cys 
    50                  55                  60                  


Leu Cys Thr Asp Asp Phe Tyr Cys Thr Val Asn Lys Leu Leu Gly Lys 
65                  70                  75                  80  


Lys Cys Ile Asn Lys Ser Asp Asn Val Lys Glu Asp Lys Phe Lys Trp 
                85                  90                  95      


Asn Leu Thr Thr Arg Ser His His Gly Phe Lys Gly Met Trp Ser Cys 
            100                 105                 110         


Leu Glu Val Ala Glu Ala Cys Val Gly Asp Val Val Cys Asn Ala Gln 
        115                 120                 125             


Leu Ala Ser Tyr Leu Lys Ala Cys Ser Ala Asn Gly Asn Pro Cys Asp 
    130                 135                 140                 


Leu Lys Gln Cys Gln Ala Ala Ile Arg Phe Phe Tyr Gln Asn Ile Pro 
145                 150                 155                 160 


Phe Asn Ile Ala Gln Met Leu Ala Phe Cys Asp Cys Ala Gln Ser Asp 
                165                 170                 175     


Ile Pro Cys Gln Gln Ser Lys Glu Ala Leu His Ser Lys Thr Cys Ala 
            180                 185                 190         


Val Asn Met Val Pro Pro Pro Thr Cys Leu Ser Val Ile Arg Ser Cys 
        195                 200                 205             


Gln Asn Asp Glu Leu Cys Arg Arg His Tyr Arg Thr Phe Gln Ser Lys 
    210                 215                 220                 


Cys Trp Gln Arg Val Thr Arg Lys Cys His Glu Asp Glu Asn Cys Ile 
225                 230                 235                 240 


Ser Thr Leu Ser Lys Gln Asp Leu Thr Cys Ser Gly Ser Asp Asp Cys 
                245                 250                 255     


Lys Ala Ala Tyr Ile Asp Ile Leu Gly Thr Val Leu Gln Val Gln Cys 
            260                 265                 270         


Thr Cys Arg Thr Ile Thr Gln Ser Glu Glu Ser Leu Cys Lys Ile Phe 
        275                 280                 285             


Gln His Met Leu His Arg Lys Ser Cys Phe Asn Tyr Pro Thr Leu Ser 
    290                 295                 300                 


Asn Val Lys Gly Met Ala Leu Tyr Thr Arg Lys His Ala Asn Lys Ile 
305                 310                 315                 320 


Thr Leu Thr Gly Phe His Ser Pro Phe Asn Gly Glu 
                325                 330         


<210>  1807
<211>  351
<212>  PRT

<213>  Artificial Sequence

<220>
<223>  GFRAL ECD fragment

<400>  1807

Met Ile Val Phe Ile Phe Leu Ala Met Gly Leu Ser Leu Glu Asn Glu 
1               5                   10                  15      


Tyr Thr Ser Gln Thr Asn Asn Cys Thr Tyr Leu Arg Glu Gln Cys Leu 
            20                  25                  30          


Arg Asp Ala Asn Gly Cys Lys His Ala Trp Arg Val Met Glu Asp Ala 
        35                  40                  45              


Cys Asn Asp Ser Asp Pro Gly Asp Pro Cys Lys Met Arg Asn Ser Ser 
    50                  55                  60                  


Tyr Cys Asn Leu Ser Ile Gln Tyr Leu Val Glu Ser Asn Phe Gln Phe 
65                  70                  75                  80  


Lys Glu Cys Leu Cys Thr Asp Asp Phe Tyr Cys Thr Val Asn Lys Leu 
                85                  90                  95      


Leu Gly Lys Lys Cys Ile Asn Lys Ser Asp Asn Val Lys Glu Asp Lys 
            100                 105                 110         


Phe Lys Trp Asn Leu Thr Thr Arg Ser His His Gly Phe Lys Gly Met 
        115                 120                 125             


Trp Ser Cys Leu Glu Val Ala Glu Ala Cys Val Gly Asp Val Val Cys 
    130                 135                 140                 


Asn Ala Gln Leu Ala Ser Tyr Leu Lys Ala Cys Ser Ala Asn Gly Asn 
145                 150                 155                 160 


Pro Cys Asp Leu Lys Gln Cys Gln Ala Ala Ile Arg Phe Phe Tyr Gln 
                165                 170                 175     


Asn Ile Pro Phe Asn Ile Ala Gln Met Leu Ala Phe Cys Asp Cys Ala 
            180                 185                 190         


Gln Ser Asp Ile Pro Cys Gln Gln Ser Lys Glu Ala Leu His Ser Lys 
        195                 200                 205             


Thr Cys Ala Val Asn Met Val Pro Pro Pro Thr Cys Leu Ser Val Ile 
    210                 215                 220                 


Arg Ser Cys Gln Asn Asp Glu Leu Cys Arg Arg His Tyr Arg Thr Phe 
225                 230                 235                 240 


Gln Ser Lys Cys Trp Gln Arg Val Thr Arg Lys Cys His Glu Asp Glu 
                245                 250                 255     


Asn Cys Ile Ser Thr Leu Ser Lys Gln Asp Leu Thr Cys Ser Gly Ser 
            260                 265                 270         


Asp Asp Cys Lys Ala Ala Tyr Ile Asp Ile Leu Gly Thr Val Leu Gln 
        275                 280                 285             


Val Gln Cys Thr Cys Arg Thr Ile Thr Gln Ser Glu Glu Ser Leu Cys 
    290                 295                 300                 


Lys Ile Phe Gln His Met Leu His Arg Lys Ser Cys Phe Asn Tyr Pro 
305                 310                 315                 320 


Thr Leu Ser Asn Val Lys Gly Met Ala Leu Tyr Thr Arg Lys His Ala 
                325                 330                 335     


Asn Lys Ile Thr Leu Thr Gly Phe His Ser Pro Phe Asn Gly Glu 
            340                 345                 350     


<210>  1808
<211>  297
<212>  PRT
<213>  Homo sapiens

<220>
<223>  GFRAL ECD fragment

<400>  1808

Gln Thr Asn Asn Cys Thr Tyr Leu Arg Glu Gln Cys Leu Arg Asp Ala 
1               5                   10                  15      


Asn Gly Cys Lys His Ala Trp Arg Val Met Glu Asp Ala Cys Asn Asp 
            20                  25                  30          


Ser Asp Pro Gly Asp Pro Cys Lys Met Arg Asn Ser Ser Tyr Cys Asn 
        35                  40                  45              


Leu Ser Ile Gln Tyr Leu Val Glu Ser Asn Phe Gln Phe Lys Glu Cys 
    50                  55                  60                  


Leu Cys Thr Asp Asp Phe Tyr Cys Thr Val Asn Lys Leu Leu Gly Lys 
65                  70                  75                  80  


Lys Cys Ile Asn Lys Ser Asp Asn Val Lys Glu Asp Lys Phe Lys Trp 
                85                  90                  95      


Asn Leu Thr Thr Arg Ser His His Gly Phe Lys Gly Met Trp Ser Cys 
            100                 105                 110         


Leu Glu Val Ala Glu Ala Cys Val Gly Asp Val Val Cys Asn Ala Gln 
        115                 120                 125             


Leu Ala Ser Tyr Leu Lys Ala Cys Ser Ala Asn Gly Asn Pro Cys Asp 
    130                 135                 140                 


Leu Lys Gln Cys Gln Ala Ala Ile Arg Phe Phe Tyr Gln Asn Ile Pro 
145                 150                 155                 160 


Phe Asn Ile Ala Gln Met Leu Ala Phe Cys Asp Cys Ala Gln Ser Asp 
                165                 170                 175     


Ile Pro Cys Gln Gln Ser Lys Glu Ala Leu His Ser Lys Thr Cys Ala 
            180                 185                 190         


Val Asn Met Val Pro Pro Pro Thr Cys Leu Ser Val Ile Arg Ser Cys 
        195                 200                 205             


Gln Asn Asp Glu Leu Cys Arg Arg His Tyr Arg Thr Phe Gln Ser Lys 
    210                 215                 220                 


Cys Trp Gln Arg Val Thr Arg Lys Cys His Glu Asp Glu Asn Cys Ile 
225                 230                 235                 240 


Ser Thr Leu Ser Lys Gln Asp Leu Thr Cys Ser Gly Ser Asp Asp Cys 
                245                 250                 255     


Lys Ala Ala Tyr Ile Asp Ile Leu Gly Thr Val Leu Gln Val Gln Cys 
            260                 265                 270         


Thr Cys Arg Thr Ile Thr Gln Ser Glu Glu Ser Leu Cys Lys Ile Phe 
        275                 280                 285             


Gln His Met Leu His Arg Lys Ser Cys 
    290                 295         


<210>  1809
<211>  237
<212>  PRT
<213>  Homo sapiens

<220>
<223>  GFRAL ECD fragment

<400>  1809

Trp Asn Leu Thr Thr Arg Ser His His Gly Phe Lys Gly Met Trp Ser 
1               5                   10                  15      


Cys Leu Glu Val Ala Glu Ala Cys Val Gly Asp Val Val Cys Asn Ala 
            20                  25                  30          


Gln Leu Ala Ser Tyr Leu Lys Ala Cys Ser Ala Asn Gly Asn Pro Cys 
        35                  40                  45              


Asp Leu Lys Gln Cys Gln Ala Ala Ile Arg Phe Phe Tyr Gln Asn Ile 
    50                  55                  60                  


Pro Phe Asn Ile Ala Gln Met Leu Ala Phe Cys Asp Cys Ala Gln Ser 
65                  70                  75                  80  


Asp Ile Pro Cys Gln Gln Ser Lys Glu Ala Leu His Ser Lys Thr Cys 
                85                  90                  95      


Ala Val Asn Met Val Pro Pro Pro Thr Cys Leu Ser Val Ile Arg Ser 
            100                 105                 110         


Cys Gln Asn Asp Glu Leu Cys Arg Arg His Tyr Arg Thr Phe Gln Ser 
        115                 120                 125             


Lys Cys Trp Gln Arg Val Thr Arg Lys Cys His Glu Asp Glu Asn Cys 
    130                 135                 140                 


Ile Ser Thr Leu Ser Lys Gln Asp Leu Thr Cys Ser Gly Ser Asp Asp 
145                 150                 155                 160 


Cys Lys Ala Ala Tyr Ile Asp Ile Leu Gly Thr Val Leu Gln Val Gln 
                165                 170                 175     


Cys Thr Cys Arg Thr Ile Thr Gln Ser Glu Glu Ser Leu Cys Lys Ile 
            180                 185                 190         


Phe Gln His Met Leu His Arg Lys Ser Cys Phe Asn Tyr Pro Thr Leu 
        195                 200                 205             


Ser Asn Val Lys Gly Met Ala Leu Tyr Thr Arg Lys His Ala Asn Lys 
    210                 215                 220                 


Ile Thr Leu Thr Gly Phe His Ser Pro Phe Asn Gly Glu 
225                 230                 235         


<210>  1810
<211>  308
<212>  PRT
<213>  Homo sapiens

<220>
<223>  precursor human GDF15 polypeptide

<400>  1810

Met Pro Gly Gln Glu Leu Arg Thr Val Asn Gly Ser Gln Met Leu Leu 
1               5                   10                  15      


Val Leu Leu Val Leu Ser Trp Leu Pro His Gly Gly Ala Leu Ser Leu 
            20                  25                  30          


Ala Glu Ala Ser Arg Ala Ser Phe Pro Gly Pro Ser Glu Leu His Ser 
        35                  40                  45              


Glu Asp Ser Arg Phe Arg Glu Leu Arg Lys Arg Tyr Glu Asp Leu Leu 
    50                  55                  60                  


Thr Arg Leu Arg Ala Asn Gln Ser Trp Glu Asp Ser Asn Thr Asp Leu 
65                  70                  75                  80  


Val Pro Ala Pro Ala Val Arg Ile Leu Thr Pro Glu Val Arg Leu Gly 
                85                  90                  95      


Ser Gly Gly His Leu His Leu Arg Ile Ser Arg Ala Ala Leu Pro Glu 
            100                 105                 110         


Gly Leu Pro Glu Ala Ser Arg Leu His Arg Ala Leu Phe Arg Leu Ser 
        115                 120                 125             


Pro Thr Ala Ser Arg Ser Trp Asp Val Thr Arg Pro Leu Arg Arg Gln 
    130                 135                 140                 


Leu Ser Leu Ala Arg Pro Gln Ala Pro Ala Leu His Leu Arg Leu Ser 
145                 150                 155                 160 


Pro Pro Pro Ser Gln Ser Asp Gln Leu Leu Ala Glu Ser Ser Ser Ala 
                165                 170                 175     


Arg Pro Gln Leu Glu Leu His Leu Arg Pro Gln Ala Ala Arg Gly Arg 
            180                 185                 190         


Arg Arg Ala Arg Ala Arg Asn Gly Asp His Cys Pro Leu Gly Pro Gly 
        195                 200                 205             


Arg Cys Cys Arg Leu His Thr Val Arg Ala Ser Leu Glu Asp Leu Gly 
    210                 215                 220                 


Trp Ala Asp Trp Val Leu Ser Pro Arg Glu Val Gln Val Thr Met Cys 
225                 230                 235                 240 


Ile Gly Ala Cys Pro Ser Gln Phe Arg Ala Ala Asn Met His Ala Gln 
                245                 250                 255     


Ile Lys Thr Ser Leu His Arg Leu Lys Pro Asp Thr Val Pro Ala Pro 
            260                 265                 270         


Cys Cys Val Pro Ala Ser Tyr Asn Pro Met Val Leu Ile Gln Lys Thr 
        275                 280                 285             


Asp Thr Gly Val Ser Leu Gln Thr Tyr Asp Asp Leu Leu Ala Lys Asp 
    290                 295                 300                 


Cys His Cys Ile 
305             


<210>  1811
<211>  112
<212>  PRT
<213>  Homo sapiens

<220>
<223>  mature human GDF15 polypeptide

<400>  1811

Ala Arg Asn Gly Asp His Cys Pro Leu Gly Pro Gly Arg Cys Cys Arg 
1               5                   10                  15      


Leu His Thr Val Arg Ala Ser Leu Glu Asp Leu Gly Trp Ala Asp Trp 
            20                  25                  30          


Val Leu Ser Pro Arg Glu Val Gln Val Thr Met Cys Ile Gly Ala Cys 
        35                  40                  45              


Pro Ser Gln Phe Arg Ala Ala Asn Met His Ala Gln Ile Lys Thr Ser 
    50                  55                  60                  


Leu His Arg Leu Lys Pro Asp Thr Val Pro Ala Pro Cys Cys Val Pro 
65                  70                  75                  80  


Ala Ser Tyr Asn Pro Met Val Leu Ile Gln Lys Thr Asp Thr Gly Val 
                85                  90                  95      


Ser Leu Gln Thr Tyr Asp Asp Leu Leu Ala Lys Asp Cys His Cys Ile 
            100                 105                 110         


<210>  1812
<211>  1049
<212>  PRT
<213>  Homo sapiens

<220>
<223>  mature human RET9

<400>  1812

Lys Val Ala Leu Gly Leu Tyr Phe Ser Arg Asp Ala Tyr Trp Glu Lys 
1               5                   10                  15      


Leu Tyr Val Asp Gln Ala Ala Gly Thr Pro Leu Leu Tyr Val His Ala 
            20                  25                  30          


Leu Arg Asp Ala Pro Glu Glu Val Pro Ser Phe Arg Leu Gly Gln His 
        35                  40                  45              


Leu Tyr Gly Thr Tyr Arg Thr Arg Leu His Glu Asn Asn Trp Ile Cys 
    50                  55                  60                  


Ile Gln Glu Asp Thr Gly Leu Leu Tyr Leu Asn Arg Ser Leu Asp His 
65                  70                  75                  80  


Ser Ser Trp Glu Lys Leu Ser Val Arg Asn Arg Gly Phe Pro Leu Leu 
                85                  90                  95      


Thr Val Tyr Leu Lys Val Phe Leu Ser Pro Thr Ser Leu Arg Glu Gly 
            100                 105                 110         


Glu Cys Gln Trp Pro Gly Cys Ala Arg Val Tyr Phe Ser Phe Phe Asn 
        115                 120                 125             


Thr Ser Phe Pro Ala Cys Ser Ser Leu Lys Pro Arg Glu Leu Cys Phe 
    130                 135                 140                 


Pro Glu Thr Arg Pro Ser Phe Arg Ile Arg Glu Asn Arg Pro Pro Gly 
145                 150                 155                 160 


Thr Phe His Gln Phe Arg Leu Leu Pro Val Gln Phe Leu Cys Pro Asn 
                165                 170                 175     


Ile Ser Val Ala Tyr Arg Leu Leu Glu Gly Glu Gly Leu Pro Phe Arg 
            180                 185                 190         


Cys Ala Pro Asp Ser Leu Glu Val Ser Thr Arg Trp Ala Leu Asp Arg 
        195                 200                 205             


Glu Gln Arg Glu Lys Tyr Glu Leu Val Ala Val Cys Thr Val His Ala 
    210                 215                 220                 


Gly Ala Arg Glu Glu Val Val Met Val Pro Phe Pro Val Thr Val Tyr 
225                 230                 235                 240 


Asp Glu Asp Asp Ser Ala Pro Thr Phe Pro Ala Gly Val Asp Thr Ala 
                245                 250                 255     


Ser Ala Val Val Glu Phe Lys Arg Lys Glu Asp Thr Val Val Ala Thr 
            260                 265                 270         


Leu Arg Val Phe Asp Ala Asp Val Val Pro Ala Ser Gly Glu Leu Val 
        275                 280                 285             


Arg Arg Tyr Thr Ser Thr Leu Leu Pro Gly Asp Thr Trp Ala Gln Gln 
    290                 295                 300                 


Thr Phe Arg Val Glu His Trp Pro Asn Glu Thr Ser Val Gln Ala Asn 
305                 310                 315                 320 


Gly Ser Phe Val Arg Ala Thr Val His Asp Tyr Arg Leu Val Leu Asn 
                325                 330                 335     


Arg Asn Leu Ser Ile Ser Glu Asn Arg Thr Met Gln Leu Ala Val Leu 
            340                 345                 350         


Val Asn Asp Ser Asp Phe Gln Gly Pro Gly Ala Gly Val Leu Leu Leu 
        355                 360                 365             


His Phe Asn Val Ser Val Leu Pro Val Ser Leu His Leu Pro Ser Thr 
    370                 375                 380                 


Tyr Ser Leu Ser Val Ser Arg Arg Ala Arg Arg Phe Ala Gln Ile Gly 
385                 390                 395                 400 


Lys Val Cys Val Glu Asn Cys Gln Ala Phe Ser Gly Ile Asn Val Gln 
                405                 410                 415     


Tyr Lys Leu His Ser Ser Gly Ala Asn Cys Ser Thr Leu Gly Val Val 
            420                 425                 430         


Thr Ser Ala Glu Asp Thr Ser Gly Ile Leu Phe Val Asn Asp Thr Lys 
        435                 440                 445             


Ala Leu Arg Arg Pro Lys Cys Ala Glu Leu His Tyr Met Val Val Ala 
    450                 455                 460                 


Thr Asp Gln Gln Thr Ser Arg Gln Ala Gln Ala Gln Leu Leu Val Thr 
465                 470                 475                 480 


Val Glu Gly Ser Tyr Val Ala Glu Glu Ala Gly Cys Pro Leu Ser Cys 
                485                 490                 495     


Ala Val Ser Lys Arg Arg Leu Glu Cys Glu Glu Cys Gly Gly Leu Gly 
            500                 505                 510         


Ser Pro Thr Gly Arg Cys Glu Trp Arg Gln Gly Asp Gly Lys Gly Ile 
        515                 520                 525             


Thr Arg Asn Phe Ser Thr Cys Ser Pro Ser Thr Lys Thr Cys Pro Asp 
    530                 535                 540                 


Gly His Cys Asp Val Val Glu Thr Gln Asp Ile Asn Ile Cys Pro Gln 
545                 550                 555                 560 


Asp Cys Leu Arg Gly Ser Ile Val Gly Gly His Glu Pro Gly Glu Pro 
                565                 570                 575     


Arg Gly Ile Lys Ala Gly Tyr Gly Thr Cys Asn Cys Phe Pro Glu Glu 
            580                 585                 590         


Glu Lys Cys Phe Cys Glu Pro Glu Asp Ile Gln Asp Pro Leu Cys Asp 
        595                 600                 605             


Glu Leu Cys Arg Thr Val Ile Ala Ala Ala Val Leu Phe Ser Phe Ile 
    610                 615                 620                 


Val Ser Val Leu Leu Ser Ala Phe Cys Ile His Cys Tyr His Lys Phe 
625                 630                 635                 640 


Ala His Lys Pro Pro Ile Ser Ser Ala Glu Met Thr Phe Arg Arg Pro 
                645                 650                 655     


Ala Gln Ala Phe Pro Val Ser Tyr Ser Ser Ser Gly Ala Arg Arg Pro 
            660                 665                 670         


Ser Leu Asp Ser Met Glu Asn Gln Val Ser Val Asp Ala Phe Lys Ile 
        675                 680                 685             


Leu Glu Asp Pro Lys Trp Glu Phe Pro Arg Lys Asn Leu Val Leu Gly 
    690                 695                 700                 


Lys Thr Leu Gly Glu Gly Glu Phe Gly Lys Val Val Lys Ala Thr Ala 
705                 710                 715                 720 


Phe His Leu Lys Gly Arg Ala Gly Tyr Thr Thr Val Ala Val Lys Met 
                725                 730                 735     


Leu Lys Glu Asn Ala Ser Pro Ser Glu Leu Arg Asp Leu Leu Ser Glu 
            740                 745                 750         


Phe Asn Val Leu Lys Gln Val Asn His Pro His Val Ile Lys Leu Tyr 
        755                 760                 765             


Gly Ala Cys Ser Gln Asp Gly Pro Leu Leu Leu Ile Val Glu Tyr Ala 
    770                 775                 780                 


Lys Tyr Gly Ser Leu Arg Gly Phe Leu Arg Glu Ser Arg Lys Val Gly 
785                 790                 795                 800 


Pro Gly Tyr Leu Gly Ser Gly Gly Ser Arg Asn Ser Ser Ser Leu Asp 
                805                 810                 815     


His Pro Asp Glu Arg Ala Leu Thr Met Gly Asp Leu Ile Ser Phe Ala 
            820                 825                 830         


Trp Gln Ile Ser Gln Gly Met Gln Tyr Leu Ala Glu Met Lys Leu Val 
        835                 840                 845             


His Arg Asp Leu Ala Ala Arg Asn Ile Leu Val Ala Glu Gly Arg Lys 
    850                 855                 860                 


Met Lys Ile Ser Asp Phe Gly Leu Ser Arg Asp Val Tyr Glu Glu Asp 
865                 870                 875                 880 


Ser Tyr Val Lys Arg Ser Gln Gly Arg Ile Pro Val Lys Trp Met Ala 
                885                 890                 895     


Ile Glu Ser Leu Phe Asp His Ile Tyr Thr Thr Gln Ser Asp Val Trp 
            900                 905                 910         


Ser Phe Gly Val Leu Leu Trp Glu Ile Val Thr Leu Gly Gly Asn Pro 
        915                 920                 925             


Tyr Pro Gly Ile Pro Pro Glu Arg Leu Phe Asn Leu Leu Lys Thr Gly 
    930                 935                 940                 


His Arg Met Glu Arg Pro Asp Asn Cys Ser Glu Glu Met Tyr Arg Leu 
945                 950                 955                 960 


Met Leu Gln Cys Trp Lys Gln Glu Pro Asp Lys Arg Pro Val Phe Ala 
                965                 970                 975     


Asp Ile Ser Lys Asp Leu Glu Lys Met Met Val Lys Arg Arg Asp Tyr 
            980                 985                 990         


Leu Asp Leu Ala Ala Ser Thr Pro  Ser Asp Ser Leu Ile  Tyr Asp Asp 
        995                 1000                 1005             


Gly Leu  Ser Glu Glu Glu Thr  Pro Leu Val Asp Cys  Asn Asn Ala 
    1010                 1015                 1020             


Pro Leu  Pro Arg Ala Leu Pro  Ser Thr Trp Ile Glu  Asn Lys Leu 
    1025                 1030                 1035             


Tyr Gly  Arg Ile Ser His Ala  Phe Thr Arg Phe 
    1040                 1045                 


<210>  1813
<211>  1072
<212>  PRT
<213>  Homo sapiens

<220>
<223>  full-length precursor human RET protein

<400>  1813

Met Ala Lys Ala Thr Ser Gly Ala Ala Gly Leu Arg Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Pro Leu Leu Gly Lys Val Ala Leu Gly Leu Tyr Phe Ser 
            20                  25                  30          


Arg Asp Ala Tyr Trp Glu Lys Leu Tyr Val Asp Gln Ala Ala Gly Thr 
        35                  40                  45              


Pro Leu Leu Tyr Val His Ala Leu Arg Asp Ala Pro Glu Glu Val Pro 
    50                  55                  60                  


Ser Phe Arg Leu Gly Gln His Leu Tyr Gly Thr Tyr Arg Thr Arg Leu 
65                  70                  75                  80  


His Glu Asn Asn Trp Ile Cys Ile Gln Glu Asp Thr Gly Leu Leu Tyr 
                85                  90                  95      


Leu Asn Arg Ser Leu Asp His Ser Ser Trp Glu Lys Leu Ser Val Arg 
            100                 105                 110         


Asn Arg Gly Phe Pro Leu Leu Thr Val Tyr Leu Lys Val Phe Leu Ser 
        115                 120                 125             


Pro Thr Ser Leu Arg Glu Gly Glu Cys Gln Trp Pro Gly Cys Ala Arg 
    130                 135                 140                 


Val Tyr Phe Ser Phe Phe Asn Thr Ser Phe Pro Ala Cys Ser Ser Leu 
145                 150                 155                 160 


Lys Pro Arg Glu Leu Cys Phe Pro Glu Thr Arg Pro Ser Phe Arg Ile 
                165                 170                 175     


Arg Glu Asn Arg Pro Pro Gly Thr Phe His Gln Phe Arg Leu Leu Pro 
            180                 185                 190         


Val Gln Phe Leu Cys Pro Asn Ile Ser Val Ala Tyr Arg Leu Leu Glu 
        195                 200                 205             


Gly Glu Gly Leu Pro Phe Arg Cys Ala Pro Asp Ser Leu Glu Val Ser 
    210                 215                 220                 


Thr Arg Trp Ala Leu Asp Arg Glu Gln Arg Glu Lys Tyr Glu Leu Val 
225                 230                 235                 240 


Ala Val Cys Thr Val His Ala Gly Ala Arg Glu Glu Val Val Met Val 
                245                 250                 255     


Pro Phe Pro Val Thr Val Tyr Asp Glu Asp Asp Ser Ala Pro Thr Phe 
            260                 265                 270         


Pro Ala Gly Val Asp Thr Ala Ser Ala Val Val Glu Phe Lys Arg Lys 
        275                 280                 285             


Glu Asp Thr Val Val Ala Thr Leu Arg Val Phe Asp Ala Asp Val Val 
    290                 295                 300                 


Pro Ala Ser Gly Glu Leu Val Arg Arg Tyr Thr Ser Thr Leu Leu Pro 
305                 310                 315                 320 


Gly Asp Thr Trp Ala Gln Gln Thr Phe Arg Val Glu His Trp Pro Asn 
                325                 330                 335     


Glu Thr Ser Val Gln Ala Asn Gly Ser Phe Val Arg Ala Thr Val His 
            340                 345                 350         


Asp Tyr Arg Leu Val Leu Asn Arg Asn Leu Ser Ile Ser Glu Asn Arg 
        355                 360                 365             


Thr Met Gln Leu Ala Val Leu Val Asn Asp Ser Asp Phe Gln Gly Pro 
    370                 375                 380                 


Gly Ala Gly Val Leu Leu Leu His Phe Asn Val Ser Val Leu Pro Val 
385                 390                 395                 400 


Ser Leu His Leu Pro Ser Thr Tyr Ser Leu Ser Val Ser Arg Arg Ala 
                405                 410                 415     


Arg Arg Phe Ala Gln Ile Gly Lys Val Cys Val Glu Asn Cys Gln Ala 
            420                 425                 430         


Phe Ser Gly Ile Asn Val Gln Tyr Lys Leu His Ser Ser Gly Ala Asn 
        435                 440                 445             


Cys Ser Thr Leu Gly Val Val Thr Ser Ala Glu Asp Thr Ser Gly Ile 
    450                 455                 460                 


Leu Phe Val Asn Asp Thr Lys Ala Leu Arg Arg Pro Lys Cys Ala Glu 
465                 470                 475                 480 


Leu His Tyr Met Val Val Ala Thr Asp Gln Gln Thr Ser Arg Gln Ala 
                485                 490                 495     


Gln Ala Gln Leu Leu Val Thr Val Glu Gly Ser Tyr Val Ala Glu Glu 
            500                 505                 510         


Ala Gly Cys Pro Leu Ser Cys Ala Val Ser Lys Arg Arg Leu Glu Cys 
        515                 520                 525             


Glu Glu Cys Gly Gly Leu Gly Ser Pro Thr Gly Arg Cys Glu Trp Arg 
    530                 535                 540                 


Gln Gly Asp Gly Lys Gly Ile Thr Arg Asn Phe Ser Thr Cys Ser Pro 
545                 550                 555                 560 


Ser Thr Lys Thr Cys Pro Asp Gly His Cys Asp Val Val Glu Thr Gln 
                565                 570                 575     


Asp Ile Asn Ile Cys Pro Gln Asp Cys Leu Arg Gly Ser Ile Val Gly 
            580                 585                 590         


Gly His Glu Pro Gly Glu Pro Arg Gly Ile Lys Ala Gly Tyr Gly Thr 
        595                 600                 605             


Cys Asn Cys Phe Pro Glu Glu Glu Lys Cys Phe Cys Glu Pro Glu Asp 
    610                 615                 620                 


Ile Gln Asp Pro Leu Cys Asp Glu Leu Cys Arg Thr Val Ile Ala Ala 
625                 630                 635                 640 


Ala Val Leu Phe Ser Phe Ile Val Ser Val Leu Leu Ser Ala Phe Cys 
                645                 650                 655     


Ile His Cys Tyr His Lys Phe Ala His Lys Pro Pro Ile Ser Ser Ala 
            660                 665                 670         


Glu Met Thr Phe Arg Arg Pro Ala Gln Ala Phe Pro Val Ser Tyr Ser 
        675                 680                 685             


Ser Ser Gly Ala Arg Arg Pro Ser Leu Asp Ser Met Glu Asn Gln Val 
    690                 695                 700                 


Ser Val Asp Ala Phe Lys Ile Leu Glu Asp Pro Lys Trp Glu Phe Pro 
705                 710                 715                 720 


Arg Lys Asn Leu Val Leu Gly Lys Thr Leu Gly Glu Gly Glu Phe Gly 
                725                 730                 735     


Lys Val Val Lys Ala Thr Ala Phe His Leu Lys Gly Arg Ala Gly Tyr 
            740                 745                 750         


Thr Thr Val Ala Val Lys Met Leu Lys Glu Asn Ala Ser Pro Ser Glu 
        755                 760                 765             


Leu Arg Asp Leu Leu Ser Glu Phe Asn Val Leu Lys Gln Val Asn His 
    770                 775                 780                 


Pro His Val Ile Lys Leu Tyr Gly Ala Cys Ser Gln Asp Gly Pro Leu 
785                 790                 795                 800 


Leu Leu Ile Val Glu Tyr Ala Lys Tyr Gly Ser Leu Arg Gly Phe Leu 
                805                 810                 815     


Arg Glu Ser Arg Lys Val Gly Pro Gly Tyr Leu Gly Ser Gly Gly Ser 
            820                 825                 830         


Arg Asn Ser Ser Ser Leu Asp His Pro Asp Glu Arg Ala Leu Thr Met 
        835                 840                 845             


Gly Asp Leu Ile Ser Phe Ala Trp Gln Ile Ser Gln Gly Met Gln Tyr 
    850                 855                 860                 


Leu Ala Glu Met Lys Leu Val His Arg Asp Leu Ala Ala Arg Asn Ile 
865                 870                 875                 880 


Leu Val Ala Glu Gly Arg Lys Met Lys Ile Ser Asp Phe Gly Leu Ser 
                885                 890                 895     


Arg Asp Val Tyr Glu Glu Asp Ser Tyr Val Lys Arg Ser Gln Gly Arg 
            900                 905                 910         


Ile Pro Val Lys Trp Met Ala Ile Glu Ser Leu Phe Asp His Ile Tyr 
        915                 920                 925             


Thr Thr Gln Ser Asp Val Trp Ser Phe Gly Val Leu Leu Trp Glu Ile 
    930                 935                 940                 


Val Thr Leu Gly Gly Asn Pro Tyr Pro Gly Ile Pro Pro Glu Arg Leu 
945                 950                 955                 960 


Phe Asn Leu Leu Lys Thr Gly His Arg Met Glu Arg Pro Asp Asn Cys 
                965                 970                 975     


Ser Glu Glu Met Tyr Arg Leu Met Leu Gln Cys Trp Lys Gln Glu Pro 
            980                 985                 990         


Asp Lys Arg Pro Val Phe Ala Asp  Ile Ser Lys Asp Leu  Glu Lys Met 
        995                 1000                 1005             


Met Val  Lys Arg Arg Asp Tyr  Leu Asp Leu Ala Ala  Ser Thr Pro 
    1010                 1015                 1020             


Ser Asp  Ser Leu Ile Tyr Asp  Asp Gly Leu Ser Glu  Glu Glu Thr 
    1025                 1030                 1035             


Pro Leu  Val Asp Cys Asn Asn  Ala Pro Leu Pro Arg  Ala Leu Pro 
    1040                 1045                 1050             


Ser Thr  Trp Ile Glu Asn Lys  Leu Tyr Gly Arg Ile  Ser His Ala 
    1055                 1060                 1065             


Phe Thr  Arg Phe 
    1070         


<210>  1814
<211>  612
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RET-ECD

<400>  1814

Lys Val Ala Leu Gly Leu Tyr Phe Ser Arg Asp Ala Tyr Trp Glu Lys 
1               5                   10                  15      


Leu Tyr Val Asp Gln Ala Ala Gly Thr Pro Leu Leu Tyr Val His Ala 
            20                  25                  30          


Leu Arg Asp Ala Pro Glu Glu Val Pro Ser Phe Arg Leu Gly Gln His 
        35                  40                  45              


Leu Tyr Gly Thr Tyr Arg Thr Arg Leu His Glu Asn Asn Trp Ile Cys 
    50                  55                  60                  


Ile Gln Glu Asp Thr Gly Leu Leu Tyr Leu Asn Arg Ser Leu Asp His 
65                  70                  75                  80  


Ser Ser Trp Glu Lys Leu Ser Val Arg Asn Arg Gly Phe Pro Leu Leu 
                85                  90                  95      


Thr Val Tyr Leu Lys Val Phe Leu Ser Pro Thr Ser Leu Arg Glu Gly 
            100                 105                 110         


Glu Cys Gln Trp Pro Gly Cys Ala Arg Val Tyr Phe Ser Phe Phe Asn 
        115                 120                 125             


Thr Ser Phe Pro Ala Cys Ser Ser Leu Lys Pro Arg Glu Leu Cys Phe 
    130                 135                 140                 


Pro Glu Thr Arg Pro Ser Phe Arg Ile Arg Glu Asn Arg Pro Pro Gly 
145                 150                 155                 160 


Thr Phe His Gln Phe Arg Leu Leu Pro Val Gln Phe Leu Cys Pro Asn 
                165                 170                 175     


Ile Ser Val Ala Tyr Arg Leu Leu Glu Gly Glu Gly Leu Pro Phe Arg 
            180                 185                 190         


Cys Ala Pro Asp Ser Leu Glu Val Ser Thr Arg Trp Ala Leu Asp Arg 
        195                 200                 205             


Glu Gln Arg Glu Lys Tyr Glu Leu Val Ala Val Cys Thr Val His Ala 
    210                 215                 220                 


Gly Ala Arg Glu Glu Val Val Met Val Pro Phe Pro Val Thr Val Tyr 
225                 230                 235                 240 


Asp Glu Asp Asp Ser Ala Pro Thr Phe Pro Ala Gly Val Asp Thr Ala 
                245                 250                 255     


Ser Ala Val Val Glu Phe Lys Arg Lys Glu Asp Thr Val Val Ala Thr 
            260                 265                 270         


Leu Arg Val Phe Asp Ala Asp Val Val Pro Ala Ser Gly Glu Leu Val 
        275                 280                 285             


Arg Arg Tyr Thr Ser Thr Leu Leu Pro Gly Asp Thr Trp Ala Gln Gln 
    290                 295                 300                 


Thr Phe Arg Val Glu His Trp Pro Asn Glu Thr Ser Val Gln Ala Asn 
305                 310                 315                 320 


Gly Ser Phe Val Arg Ala Thr Val His Asp Tyr Arg Leu Val Leu Asn 
                325                 330                 335     


Arg Asn Leu Ser Ile Ser Glu Asn Arg Thr Met Gln Leu Ala Val Leu 
            340                 345                 350         


Val Asn Asp Ser Asp Phe Gln Gly Pro Gly Ala Gly Val Leu Leu Leu 
        355                 360                 365             


His Phe Asn Val Ser Val Leu Pro Val Ser Leu His Leu Pro Ser Thr 
    370                 375                 380                 


Tyr Ser Leu Ser Val Ser Arg Arg Ala Arg Arg Phe Ala Gln Ile Gly 
385                 390                 395                 400 


Lys Val Cys Val Glu Asn Cys Gln Ala Phe Ser Gly Ile Asn Val Gln 
                405                 410                 415     


Tyr Lys Leu His Ser Ser Gly Ala Asn Cys Ser Thr Leu Gly Val Val 
            420                 425                 430         


Thr Ser Ala Glu Asp Thr Ser Gly Ile Leu Phe Val Asn Asp Thr Lys 
        435                 440                 445             


Ala Leu Arg Arg Pro Lys Cys Ala Glu Leu His Tyr Met Val Val Ala 
    450                 455                 460                 


Thr Asp Gln Gln Thr Ser Arg Gln Ala Gln Ala Gln Leu Leu Val Thr 
465                 470                 475                 480 


Val Glu Gly Ser Tyr Val Ala Glu Glu Ala Gly Cys Pro Leu Ser Cys 
                485                 490                 495     


Ala Val Ser Lys Arg Arg Leu Glu Cys Glu Glu Cys Gly Gly Leu Gly 
            500                 505                 510         


Ser Pro Thr Gly Arg Cys Glu Trp Arg Gln Gly Asp Gly Lys Gly Ile 
        515                 520                 525             


Thr Arg Asn Phe Ser Thr Cys Ser Pro Ser Thr Lys Thr Cys Pro Asp 
    530                 535                 540                 


Gly His Cys Asp Val Val Glu Thr Gln Asp Ile Asn Ile Cys Pro Gln 
545                 550                 555                 560 


Asp Cys Leu Arg Gly Ser Ile Val Gly Gly His Glu Pro Gly Glu Pro 
                565                 570                 575     


Arg Gly Ile Lys Ala Gly Tyr Gly Thr Cys Asn Cys Phe Pro Glu Glu 
            580                 585                 590         


Glu Lys Cys Phe Cys Glu Pro Glu Asp Ile Gln Asp Pro Leu Cys Asp 
        595                 600                 605             


Glu Leu Cys Arg 
    610         


<210>  1815
<211>  607
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RET-ECD

<400>  1815

Leu Tyr Phe Ser Arg Asp Ala Tyr Trp Glu Lys Leu Tyr Val Asp Gln 
1               5                   10                  15      


Ala Ala Gly Thr Pro Leu Leu Tyr Val His Ala Leu Arg Asp Ala Pro 
            20                  25                  30          


Glu Glu Val Pro Ser Phe Arg Leu Gly Gln His Leu Tyr Gly Thr Tyr 
        35                  40                  45              


Arg Thr Arg Leu His Glu Asn Asn Trp Ile Cys Ile Gln Glu Asp Thr 
    50                  55                  60                  


Gly Leu Leu Tyr Leu Asn Arg Ser Leu Asp His Ser Ser Trp Glu Lys 
65                  70                  75                  80  


Leu Ser Val Arg Asn Arg Gly Phe Pro Leu Leu Thr Val Tyr Leu Lys 
                85                  90                  95      


Val Phe Leu Ser Pro Thr Ser Leu Arg Glu Gly Glu Cys Gln Trp Pro 
            100                 105                 110         


Gly Cys Ala Arg Val Tyr Phe Ser Phe Phe Asn Thr Ser Phe Pro Ala 
        115                 120                 125             


Cys Ser Ser Leu Lys Pro Arg Glu Leu Cys Phe Pro Glu Thr Arg Pro 
    130                 135                 140                 


Ser Phe Arg Ile Arg Glu Asn Arg Pro Pro Gly Thr Phe His Gln Phe 
145                 150                 155                 160 


Arg Leu Leu Pro Val Gln Phe Leu Cys Pro Asn Ile Ser Val Ala Tyr 
                165                 170                 175     


Arg Leu Leu Glu Gly Glu Gly Leu Pro Phe Arg Cys Ala Pro Asp Ser 
            180                 185                 190         


Leu Glu Val Ser Thr Arg Trp Ala Leu Asp Arg Glu Gln Arg Glu Lys 
        195                 200                 205             


Tyr Glu Leu Val Ala Val Cys Thr Val His Ala Gly Ala Arg Glu Glu 
    210                 215                 220                 


Val Val Met Val Pro Phe Pro Val Thr Val Tyr Asp Glu Asp Asp Ser 
225                 230                 235                 240 


Ala Pro Thr Phe Pro Ala Gly Val Asp Thr Ala Ser Ala Val Val Glu 
                245                 250                 255     


Phe Lys Arg Lys Glu Asp Thr Val Val Ala Thr Leu Arg Val Phe Asp 
            260                 265                 270         


Ala Asp Val Val Pro Ala Ser Gly Glu Leu Val Arg Arg Tyr Thr Ser 
        275                 280                 285             


Thr Leu Leu Pro Gly Asp Thr Trp Ala Gln Gln Thr Phe Arg Val Glu 
    290                 295                 300                 


His Trp Pro Asn Glu Thr Ser Val Gln Ala Asn Gly Ser Phe Val Arg 
305                 310                 315                 320 


Ala Thr Val His Asp Tyr Arg Leu Val Leu Asn Arg Asn Leu Ser Ile 
                325                 330                 335     


Ser Glu Asn Arg Thr Met Gln Leu Ala Val Leu Val Asn Asp Ser Asp 
            340                 345                 350         


Phe Gln Gly Pro Gly Ala Gly Val Leu Leu Leu His Phe Asn Val Ser 
        355                 360                 365             


Val Leu Pro Val Ser Leu His Leu Pro Ser Thr Tyr Ser Leu Ser Val 
    370                 375                 380                 


Ser Arg Arg Ala Arg Arg Phe Ala Gln Ile Gly Lys Val Cys Val Glu 
385                 390                 395                 400 


Asn Cys Gln Ala Phe Ser Gly Ile Asn Val Gln Tyr Lys Leu His Ser 
                405                 410                 415     


Ser Gly Ala Asn Cys Ser Thr Leu Gly Val Val Thr Ser Ala Glu Asp 
            420                 425                 430         


Thr Ser Gly Ile Leu Phe Val Asn Asp Thr Lys Ala Leu Arg Arg Pro 
        435                 440                 445             


Lys Cys Ala Glu Leu His Tyr Met Val Val Ala Thr Asp Gln Gln Thr 
    450                 455                 460                 


Ser Arg Gln Ala Gln Ala Gln Leu Leu Val Thr Val Glu Gly Ser Tyr 
465                 470                 475                 480 


Val Ala Glu Glu Ala Gly Cys Pro Leu Ser Cys Ala Val Ser Lys Arg 
                485                 490                 495     


Arg Leu Glu Cys Glu Glu Cys Gly Gly Leu Gly Ser Pro Thr Gly Arg 
            500                 505                 510         


Cys Glu Trp Arg Gln Gly Asp Gly Lys Gly Ile Thr Arg Asn Phe Ser 
        515                 520                 525             


Thr Cys Ser Pro Ser Thr Lys Thr Cys Pro Asp Gly His Cys Asp Val 
    530                 535                 540                 


Val Glu Thr Gln Asp Ile Asn Ile Cys Pro Gln Asp Cys Leu Arg Gly 
545                 550                 555                 560 


Ser Ile Val Gly Gly His Glu Pro Gly Glu Pro Arg Gly Ile Lys Ala 
                565                 570                 575     


Gly Tyr Gly Thr Cys Asn Cys Phe Pro Glu Glu Glu Lys Cys Phe Cys 
            580                 585                 590         


Glu Pro Glu Asp Ile Gln Asp Pro Leu Cys Asp Glu Leu Cys Arg 
        595                 600                 605         


<210>  1816
<211>  607
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RET-ECD fragment

<400>  1816

Leu Tyr Phe Ser Arg Asp Ala Tyr Trp Glu Lys Leu Tyr Val Asp Gln 
1               5                   10                  15      


Ala Ala Gly Thr Pro Leu Leu Tyr Val His Ala Leu Arg Asp Ala Pro 
            20                  25                  30          


Glu Glu Val Pro Ser Phe Arg Leu Gly Gln His Leu Tyr Gly Thr Tyr 
        35                  40                  45              


Arg Thr Arg Leu His Glu Asn Asn Trp Ile Cys Ile Gln Glu Asp Thr 
    50                  55                  60                  


Gly Leu Leu Tyr Leu Asn Arg Ser Leu Asp His Ser Ser Trp Glu Lys 
65                  70                  75                  80  


Leu Ser Val Arg Asn Arg Gly Phe Pro Leu Leu Thr Val Tyr Leu Lys 
                85                  90                  95      


Val Phe Leu Ser Pro Thr Ser Leu Arg Glu Gly Glu Cys Gln Trp Pro 
            100                 105                 110         


Gly Cys Ala Arg Val Tyr Phe Ser Phe Phe Asn Thr Ser Phe Pro Ala 
        115                 120                 125             


Cys Ser Ser Leu Lys Pro Arg Glu Leu Cys Phe Pro Glu Thr Arg Pro 
    130                 135                 140                 


Ser Phe Arg Ile Arg Glu Asn Arg Pro Pro Gly Thr Phe His Gln Phe 
145                 150                 155                 160 


Arg Leu Leu Pro Val Gln Phe Leu Cys Pro Asn Ile Ser Val Ala Tyr 
                165                 170                 175     


Arg Leu Leu Glu Gly Glu Gly Leu Pro Phe Arg Cys Ala Pro Asp Ser 
            180                 185                 190         


Leu Glu Val Ser Thr Arg Trp Ala Leu Asp Arg Glu Gln Arg Glu Lys 
        195                 200                 205             


Tyr Glu Leu Val Ala Val Cys Thr Val His Ala Gly Ala Arg Glu Glu 
    210                 215                 220                 


Val Val Met Val Pro Phe Pro Val Thr Val Tyr Asp Glu Asp Asp Ser 
225                 230                 235                 240 


Ala Pro Thr Phe Pro Ala Gly Val Asp Thr Ala Ser Ala Val Val Glu 
                245                 250                 255     


Phe Lys Arg Lys Glu Asp Thr Val Val Ala Thr Leu Arg Val Phe Asp 
            260                 265                 270         


Ala Asp Val Val Pro Ala Ser Gly Glu Leu Val Arg Arg Tyr Thr Ser 
        275                 280                 285             


Thr Leu Leu Pro Gly Asp Thr Trp Ala Gln Gln Thr Phe Arg Val Glu 
    290                 295                 300                 


His Trp Pro Asn Glu Thr Ser Val Gln Ala Asn Gly Ser Phe Val Arg 
305                 310                 315                 320 


Ala Thr Val His Asp Tyr Arg Leu Val Leu Asn Arg Asn Leu Ser Ile 
                325                 330                 335     


Ser Glu Asn Arg Thr Met Gln Leu Ala Val Leu Val Asn Asp Ser Asp 
            340                 345                 350         


Phe Gln Gly Pro Gly Ala Gly Val Leu Leu Leu His Phe Asn Val Ser 
        355                 360                 365             


Val Leu Pro Val Ser Leu His Leu Pro Ser Thr Tyr Ser Leu Ser Val 
    370                 375                 380                 


Ser Arg Arg Ala Arg Arg Phe Ala Gln Ile Gly Lys Val Cys Val Glu 
385                 390                 395                 400 


Asn Cys Gln Ala Phe Ser Gly Ile Asn Val Gln Tyr Lys Leu His Ser 
                405                 410                 415     


Ser Gly Ala Asn Cys Ser Thr Leu Gly Val Val Thr Ser Ala Glu Asp 
            420                 425                 430         


Thr Ser Gly Ile Leu Phe Val Asn Asp Thr Lys Ala Leu Arg Arg Pro 
        435                 440                 445             


Lys Cys Ala Glu Leu His Tyr Met Val Val Ala Thr Asp Gln Gln Thr 
    450                 455                 460                 


Ser Arg Gln Ala Gln Ala Gln Leu Leu Val Thr Val Glu Gly Ser Tyr 
465                 470                 475                 480 


Val Ala Glu Glu Ala Gly Cys Pro Leu Ser Cys Ala Val Ser Lys Arg 
                485                 490                 495     


Arg Leu Glu Cys Glu Glu Cys Gly Gly Leu Gly Ser Pro Thr Gly Arg 
            500                 505                 510         


Cys Glu Trp Arg Gln Gly Asp Gly Lys Gly Ile Thr Arg Asn Phe Ser 
        515                 520                 525             


Thr Cys Ser Pro Ser Thr Lys Thr Cys Pro Asp Gly His Cys Asp Val 
    530                 535                 540                 


Val Glu Thr Gln Asp Ile Asn Ile Cys Pro Gln Asp Cys Leu Arg Gly 
545                 550                 555                 560 


Ser Ile Val Gly Gly His Glu Pro Gly Glu Pro Arg Gly Ile Lys Ala 
                565                 570                 575     


Gly Tyr Gly Thr Cys Asn Cys Phe Pro Glu Glu Glu Lys Cys Phe Cys 
            580                 585                 590         


Glu Pro Glu Asp Ile Gln Asp Pro Leu Cys Asp Glu Leu Cys Arg 
        595                 600                 605         


<210>  1817
<211>  419
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Construct 1 (IgK-2Flag-GFRAL)

<400>  1817

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Asp Tyr Lys Asp Asp Asp Asp Lys Ser Ala 
            20                  25                  30          


Gly Gly Asp Tyr Lys Asp Asp Asp Asp Lys Gly Gly Gln Thr Asn Asn 
        35                  40                  45              


Cys Thr Tyr Leu Arg Glu Gln Cys Leu Arg Asp Ala Asn Gly Cys Lys 
    50                  55                  60                  


His Ala Trp Arg Val Met Glu Asp Ala Cys Asn Asp Ser Asp Pro Gly 
65                  70                  75                  80  


Asp Pro Cys Lys Met Arg Asn Ser Ser Tyr Cys Asn Leu Ser Ile Gln 
                85                  90                  95      


Tyr Leu Val Glu Ser Asn Phe Gln Phe Lys Glu Cys Leu Cys Thr Asp 
            100                 105                 110         


Asp Phe Tyr Cys Thr Val Asn Lys Leu Leu Gly Lys Lys Cys Ile Asn 
        115                 120                 125             


Lys Ser Asp Asn Val Lys Glu Asp Lys Phe Lys Trp Asn Leu Thr Thr 
    130                 135                 140                 


Arg Ser His His Gly Phe Lys Gly Met Trp Ser Cys Leu Glu Val Ala 
145                 150                 155                 160 


Glu Ala Cys Val Gly Asp Val Val Cys Asn Ala Gln Leu Ala Ser Tyr 
                165                 170                 175     


Leu Lys Ala Cys Ser Ala Asn Gly Asn Pro Cys Asp Leu Lys Gln Cys 
            180                 185                 190         


Gln Ala Ala Ile Arg Phe Phe Tyr Gln Asn Ile Pro Phe Asn Ile Ala 
        195                 200                 205             


Gln Met Leu Ala Phe Cys Asp Cys Ala Gln Ser Asp Ile Pro Cys Gln 
    210                 215                 220                 


Gln Ser Lys Glu Ala Leu His Ser Lys Thr Cys Ala Val Asn Met Val 
225                 230                 235                 240 


Pro Pro Pro Thr Cys Leu Ser Val Ile Arg Ser Cys Gln Asn Asp Glu 
                245                 250                 255     


Leu Cys Arg Arg His Tyr Arg Thr Phe Gln Ser Lys Cys Trp Gln Arg 
            260                 265                 270         


Val Thr Arg Lys Cys His Glu Asp Glu Asn Cys Ile Ser Thr Leu Ser 
        275                 280                 285             


Lys Gln Asp Leu Thr Cys Ser Gly Ser Asp Asp Cys Lys Ala Ala Tyr 
    290                 295                 300                 


Ile Asp Ile Leu Gly Thr Val Leu Gln Val Gln Cys Thr Cys Arg Thr 
305                 310                 315                 320 


Ile Thr Gln Ser Glu Glu Ser Leu Cys Lys Ile Phe Gln His Met Leu 
                325                 330                 335     


His Arg Lys Ser Cys Phe Asn Tyr Pro Thr Leu Ser Asn Val Lys Gly 
            340                 345                 350         


Met Ala Leu Tyr Thr Arg Lys His Ala Asn Lys Ile Thr Leu Thr Gly 
        355                 360                 365             


Phe His Ser Pro Phe Asn Gly Glu Val Ile Tyr Ala Ala Met Cys Met 
    370                 375                 380                 


Thr Val Thr Cys Gly Ile Leu Leu Leu Val Met Val Lys Leu Arg Thr 
385                 390                 395                 400 


Ser Arg Ile Ser Ser Lys Ala Arg Asp Pro Ser Ser Ile Gln Ile Pro 
                405                 410                 415     


Gly Glu Leu 
            


<210>  1818
<211>  233
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Construct 2 (IgK-2Flag-GFRAL domain 1)

<400>  1818

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Asp Tyr Lys Asp Asp Asp Asp Lys Ser Ala 
            20                  25                  30          


Gly Gly Asp Tyr Lys Asp Asp Asp Asp Lys Gly Gly Gln Thr Asn Asn 
        35                  40                  45              


Cys Thr Tyr Leu Arg Glu Gln Cys Leu Arg Asp Ala Asn Gly Cys Lys 
    50                  55                  60                  


His Ala Trp Arg Val Met Glu Asp Ala Cys Asn Asp Ser Asp Pro Gly 
65                  70                  75                  80  


Asp Pro Cys Lys Met Arg Asn Ser Ser Tyr Cys Asn Leu Ser Ile Gln 
                85                  90                  95      


Tyr Leu Val Glu Ser Asn Phe Gln Phe Lys Glu Cys Leu Cys Thr Asp 
            100                 105                 110         


Asp Phe Tyr Cys Thr Val Asn Lys Leu Leu Gly Lys Lys Cys Ile Asn 
        115                 120                 125             


Lys Ser Asp Asn Val Lys Glu Asp Lys Phe Lys Trp Asn Leu Thr Thr 
    130                 135                 140                 


Arg Ser His His Gly Phe Lys Gly Met Trp Ser Phe Asn Tyr Pro Thr 
145                 150                 155                 160 


Leu Ser Asn Val Lys Gly Met Ala Leu Tyr Thr Arg Lys His Ala Asn 
                165                 170                 175     


Lys Ile Thr Leu Thr Gly Phe His Ser Pro Phe Asn Gly Glu Val Ile 
            180                 185                 190         


Tyr Ala Ala Met Cys Met Thr Val Thr Cys Gly Ile Leu Leu Leu Val 
        195                 200                 205             


Met Val Lys Leu Arg Thr Ser Arg Ile Ser Ser Lys Ala Arg Asp Pro 
    210                 215                 220                 


Ser Ser Ile Gln Ile Pro Gly Glu Leu 
225                 230             


<210>  1819
<211>  212
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Construct 3 (IgK-2Flag-GFRAL domain 2)

<400>  1819

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Asp Tyr Lys Asp Asp Asp Asp Lys Ser Ala 
            20                  25                  30          


Gly Gly Asp Tyr Lys Asp Asp Asp Asp Lys Gly Gly Ser His His Gly 
        35                  40                  45              


Phe Lys Gly Met Trp Ser Cys Leu Glu Val Ala Glu Ala Cys Val Gly 
    50                  55                  60                  


Asp Val Val Cys Asn Ala Gln Leu Ala Ser Tyr Leu Lys Ala Cys Ser 
65                  70                  75                  80  


Ala Asn Gly Asn Pro Cys Asp Leu Lys Gln Cys Gln Ala Ala Ile Arg 
                85                  90                  95      


Phe Phe Tyr Gln Asn Ile Pro Phe Asn Ile Ala Gln Met Leu Ala Phe 
            100                 105                 110         


Cys Asp Cys Ala Gln Ser Asp Ile Pro Cys Gln Gln Ser Lys Glu Ala 
        115                 120                 125             


Leu His Ser Lys Thr Cys Phe Asn Tyr Pro Thr Leu Ser Asn Val Lys 
    130                 135                 140                 


Gly Met Ala Leu Tyr Thr Arg Lys His Ala Asn Lys Ile Thr Leu Thr 
145                 150                 155                 160 


Gly Phe His Ser Pro Phe Asn Gly Glu Val Ile Tyr Ala Ala Met Cys 
                165                 170                 175     


Met Thr Val Thr Cys Gly Ile Leu Leu Leu Val Met Val Lys Leu Arg 
            180                 185                 190         


Thr Ser Arg Ile Ser Ser Lys Ala Arg Asp Pro Ser Ser Ile Gln Ile 
        195                 200                 205             


Pro Gly Glu Leu 
    210         


<210>  1820
<211>  313
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Construct 4 (IgK-2Flag-GFRAL domain 1+2)

<400>  1820

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Asp Tyr Lys Asp Asp Asp Asp Lys Ser Ala 
            20                  25                  30          


Gly Gly Asp Tyr Lys Asp Asp Asp Asp Lys Gly Gly Gln Thr Asn Asn 
        35                  40                  45              


Cys Thr Tyr Leu Arg Glu Gln Cys Leu Arg Asp Ala Asn Gly Cys Lys 
    50                  55                  60                  


His Ala Trp Arg Val Met Glu Asp Ala Cys Asn Asp Ser Asp Pro Gly 
65                  70                  75                  80  


Asp Pro Cys Lys Met Arg Asn Ser Ser Tyr Cys Asn Leu Ser Ile Gln 
                85                  90                  95      


Tyr Leu Val Glu Ser Asn Phe Gln Phe Lys Glu Cys Leu Cys Thr Asp 
            100                 105                 110         


Asp Phe Tyr Cys Thr Val Asn Lys Leu Leu Gly Lys Lys Cys Ile Asn 
        115                 120                 125             


Lys Ser Asp Asn Val Lys Glu Asp Lys Phe Lys Trp Asn Leu Thr Thr 
    130                 135                 140                 


Arg Ser His His Gly Phe Lys Gly Met Trp Ser Cys Leu Glu Val Ala 
145                 150                 155                 160 


Glu Ala Cys Val Gly Asp Val Val Cys Asn Ala Gln Leu Ala Ser Tyr 
                165                 170                 175     


Leu Lys Ala Cys Ser Ala Asn Gly Asn Pro Cys Asp Leu Lys Gln Cys 
            180                 185                 190         


Gln Ala Ala Ile Arg Phe Phe Tyr Gln Asn Ile Pro Phe Asn Ile Ala 
        195                 200                 205             


Gln Met Leu Ala Phe Cys Asp Cys Ala Gln Ser Asp Ile Pro Cys Gln 
    210                 215                 220                 


Gln Ser Lys Glu Ala Leu His Ser Lys Thr Cys Phe Asn Tyr Pro Thr 
225                 230                 235                 240 


Leu Ser Asn Val Lys Gly Met Ala Leu Tyr Thr Arg Lys His Ala Asn 
                245                 250                 255     


Lys Ile Thr Leu Thr Gly Phe His Ser Pro Phe Asn Gly Glu Val Ile 
            260                 265                 270         


Tyr Ala Ala Met Cys Met Thr Val Thr Cys Gly Ile Leu Leu Leu Val 
        275                 280                 285             


Met Val Lys Leu Arg Thr Ser Arg Ile Ser Ser Lys Ala Arg Asp Pro 
    290                 295                 300                 


Ser Ser Ile Gln Ile Pro Gly Glu Leu 
305                 310             


<210>  1821
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Construct 5 (IgK-2Flag-GFRAL domain 1+3)

<400>  1821

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Asp Tyr Lys Asp Asp Asp Asp Lys Ser Ala 
            20                  25                  30          


Gly Gly Asp Tyr Lys Asp Asp Asp Asp Lys Gly Gly Gln Thr Asn Asn 
        35                  40                  45              


Cys Thr Tyr Leu Arg Glu Gln Cys Leu Arg Asp Ala Asn Gly Cys Lys 
    50                  55                  60                  


His Ala Trp Arg Val Met Glu Asp Ala Cys Asn Asp Ser Asp Pro Gly 
65                  70                  75                  80  


Asp Pro Cys Lys Met Arg Asn Ser Ser Tyr Cys Asn Leu Ser Ile Gln 
                85                  90                  95      


Tyr Leu Val Glu Ser Asn Phe Gln Phe Lys Glu Cys Leu Cys Thr Asp 
            100                 105                 110         


Asp Phe Tyr Cys Thr Val Asn Lys Leu Leu Gly Lys Lys Cys Ile Asn 
        115                 120                 125             


Lys Ser Asp Asn Val Lys Glu Asp Lys Phe Lys Trp Asn Leu Thr Thr 
    130                 135                 140                 


Arg Ser His His Gly Phe Lys Gly Met Trp Ser Cys Leu Ser Val Ile 
145                 150                 155                 160 


Arg Ser Cys Gln Asn Asp Glu Leu Cys Arg Arg His Tyr Arg Thr Phe 
                165                 170                 175     


Gln Ser Lys Cys Trp Gln Arg Val Thr Arg Lys Cys His Glu Asp Glu 
            180                 185                 190         


Asn Cys Ile Ser Thr Leu Ser Lys Gln Asp Leu Thr Cys Ser Gly Ser 
        195                 200                 205             


Asp Asp Cys Lys Ala Ala Tyr Ile Asp Ile Leu Gly Thr Val Leu Gln 
    210                 215                 220                 


Val Gln Cys Thr Cys Arg Thr Ile Thr Gln Ser Glu Glu Ser Leu Cys 
225                 230                 235                 240 


Lys Ile Phe Gln His Met Leu His Arg Lys Ser Cys Phe Asn Tyr Pro 
                245                 250                 255     


Thr Leu Ser Asn Val Lys Gly Met Ala Leu Tyr Thr Arg Lys His Ala 
            260                 265                 270         


Asn Lys Ile Thr Leu Thr Gly Phe His Ser Pro Phe Asn Gly Glu Val 
        275                 280                 285             


Ile Tyr Ala Ala Met Cys Met Thr Val Thr Cys Gly Ile Leu Leu Leu 
    290                 295                 300                 


Val Met Val Lys Leu Arg Thr Ser Arg Ile Ser Ser Lys Ala Arg Asp 
305                 310                 315                 320 


Pro Ser Ser Ile Gln Ile Pro Gly Glu Leu 
                325                 330 


<210>  1822
<211>  318
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Construct 6 (IgK-2Flag-GFRAL domain 2+3)

<400>  1822

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Asp Tyr Lys Asp Asp Asp Asp Lys Ser Ala 
            20                  25                  30          


Gly Gly Asp Tyr Lys Asp Asp Asp Asp Lys Gly Gly Ser His His Gly 
        35                  40                  45              


Phe Lys Gly Met Trp Ser Cys Leu Glu Val Ala Glu Ala Cys Val Gly 
    50                  55                  60                  


Asp Val Val Cys Asn Ala Gln Leu Ala Ser Tyr Leu Lys Ala Cys Ser 
65                  70                  75                  80  


Ala Asn Gly Asn Pro Cys Asp Leu Lys Gln Cys Gln Ala Ala Ile Arg 
                85                  90                  95      


Phe Phe Tyr Gln Asn Ile Pro Phe Asn Ile Ala Gln Met Leu Ala Phe 
            100                 105                 110         


Cys Asp Cys Ala Gln Ser Asp Ile Pro Cys Gln Gln Ser Lys Glu Ala 
        115                 120                 125             


Leu His Ser Lys Thr Cys Ala Val Asn Met Val Pro Pro Pro Thr Cys 
    130                 135                 140                 


Leu Ser Val Ile Arg Ser Cys Gln Asn Asp Glu Leu Cys Arg Arg His 
145                 150                 155                 160 


Tyr Arg Thr Phe Gln Ser Lys Cys Trp Gln Arg Val Thr Arg Lys Cys 
                165                 170                 175     


His Glu Asp Glu Asn Cys Ile Ser Thr Leu Ser Lys Gln Asp Leu Thr 
            180                 185                 190         


Cys Ser Gly Ser Asp Asp Cys Lys Ala Ala Tyr Ile Asp Ile Leu Gly 
        195                 200                 205             


Thr Val Leu Gln Val Gln Cys Thr Cys Arg Thr Ile Thr Gln Ser Glu 
    210                 215                 220                 


Glu Ser Leu Cys Lys Ile Phe Gln His Met Leu His Arg Lys Ser Cys 
225                 230                 235                 240 


Phe Asn Tyr Pro Thr Leu Ser Asn Val Lys Gly Met Ala Leu Tyr Thr 
                245                 250                 255     


Arg Lys His Ala Asn Lys Ile Thr Leu Thr Gly Phe His Ser Pro Phe 
            260                 265                 270         


Asn Gly Glu Val Ile Tyr Ala Ala Met Cys Met Thr Val Thr Cys Gly 
        275                 280                 285             


Ile Leu Leu Leu Val Met Val Lys Leu Arg Thr Ser Arg Ile Ser Ser 
    290                 295                 300                 


Lys Ala Arg Asp Pro Ser Ser Ile Gln Ile Pro Gly Glu Leu 
305                 310                 315             


<210>  1823
<211>  228
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Construct 7 (IgK-2Flag-GFRAL domain 3)

<400>  1823

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Asp Tyr Lys Asp Asp Asp Asp Lys Ser Ala 
            20                  25                  30          


Gly Gly Asp Tyr Lys Asp Asp Asp Asp Lys Gly Gly Ala Val Asn Met 
        35                  40                  45              


Val Pro Pro Pro Thr Cys Leu Ser Val Ile Arg Ser Cys Gln Asn Asp 
    50                  55                  60                  


Glu Leu Cys Arg Arg His Tyr Arg Thr Phe Gln Ser Lys Cys Trp Gln 
65                  70                  75                  80  


Arg Val Thr Arg Lys Cys His Glu Asp Glu Asn Cys Ile Ser Thr Leu 
                85                  90                  95      


Ser Lys Gln Asp Leu Thr Cys Ser Gly Ser Asp Asp Cys Lys Ala Ala 
            100                 105                 110         


Tyr Ile Asp Ile Leu Gly Thr Val Leu Gln Val Gln Cys Thr Cys Arg 
        115                 120                 125             


Thr Ile Thr Gln Ser Glu Glu Ser Leu Cys Lys Ile Phe Gln His Met 
    130                 135                 140                 


Leu His Arg Lys Ser Cys Phe Asn Tyr Pro Thr Leu Ser Asn Val Lys 
145                 150                 155                 160 


Gly Met Ala Leu Tyr Thr Arg Lys His Ala Asn Lys Ile Thr Leu Thr 
                165                 170                 175     


Gly Phe His Ser Pro Phe Asn Gly Glu Val Ile Tyr Ala Ala Met Cys 
            180                 185                 190         


Met Thr Val Thr Cys Gly Ile Leu Leu Leu Val Met Val Lys Leu Arg 
        195                 200                 205             


Thr Ser Arg Ile Ser Ser Lys Ala Arg Asp Pro Ser Ser Ile Gln Ile 
    210                 215                 220                 


Pro Gly Glu Leu 
225             


<210>  1824
<211>  225
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3P10 Fab Hc

<400>  1824

Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Gly Val Ile Trp Val Lys Gln Ala Pro Gly Lys Ala Leu Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Asp Leu 
    50                  55                  60                  


Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Ser Ala Ser 
65                  70                  75                  80  


Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Arg Tyr Gly Pro Glu Asp Ile Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Leu Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Glu Val 
    210                 215                 220                 


Asp 
225 


<210>  1825
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3P10 Fab Lc

<400>  1825

Asp Ile Val Leu Thr Gln Ser Pro Val Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Asn Tyr 
            20                  25                  30          


Gly Ile Ser Phe Met Ser Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Ala Ala Ser His Gln Gly Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu Asn Ile His 
65                  70                  75                  80  


Pro Met Glu Glu Asp Asp Ser Ala Met Tyr Phe Cys Leu Gln Ser Lys 
                85                  90                  95      


Glu Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             


<210>  1826
<211>  232
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  25M22 Fab Hc

<400>  1826

Gln Val Gln Leu Gln Gln Ser Gly Pro Asp Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Val Asn Trp Met Lys Gln Arg Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Tyr Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ala Tyr Leu Leu Arg Leu Arg Arg Thr Gly Tyr Tyr Ala Met 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala Ser Thr 
        115                 120                 125             


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
    130                 135                 140                 


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
145                 150                 155                 160 


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
                165                 170                 175     


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
            180                 185                 190         


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
        195                 200                 205             


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu 
    210                 215                 220                 


Pro Lys Ser Cys Asp Glu Val Asp 
225                 230         


<210>  1827
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  25M22 Fab Lc

<400>  1827

Asp Val Val Leu Thr Gln Thr Pro Leu Ser Leu Pro Val Asn Ile Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Lys Ser Thr Lys Ser Leu Leu Asn Ser 
            20                  25                  30          


Asp Glu Phe Thr Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Phe Leu Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Ser 
                85                  90                  95      


Asn Tyr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  1828
<211>  224
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  8D8 Fab Hc

<400>  1828

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Arg Tyr 
            20                  25                  30          


Ser Val His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Met Ile Trp Gly Phe Gly Ser Thr Asp Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Thr Lys Asp Asn Ser Lys Ser Gln Phe Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ile His Thr Thr Ala Gly Ser Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ala Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Glu Val Asp Gly 
    210                 215                 220                 


<210>  1829
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  8D8 Fab Lc

<400>  1829

Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser Thr Ser Ile Gly 
1               5                   10                  15      


Asp Arg Val Ser Val Thr Cys Lys Ala Ser Gln Asn Val Gly Thr Asn 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Ala Leu Val 
        35                  40                  45              


Tyr Ser Thr Ser Tyr Arg Tyr Ser Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Glu Tyr Phe Cys His Gln Tyr Asn Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  1830
<211>  230
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5F12 Fab Hc

<400>  1830

Gln Val Gln Leu Lys Gln Ser Gly Thr Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Ile Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Ala Arg Ile Tyr Pro Gly Asn Gly Asn Thr Tyr His Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Glu Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Glu Gly Leu Tyr Tyr Asp Tyr Asp Arg Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Ala Leu Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    130                 135                 140                 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        195                 200                 205             


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
    210                 215                 220                 


Cys Asp Glu Val Asp Gly 
225                 230 


<210>  1831
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5F12 Fab Lc

<400>  1831

Asn Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Thr Tyr 
            20                  25                  30          


Gly Asn Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asp 
65                  70                  75                  80  


Pro Val Glu Ala Asp Asp Ala Ala Thr Tyr Tyr Cys His Gln Asn Asn 
                85                  90                  95      


Glu Asp Pro Pro Ala Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             


<210>  1832
<211>  394
<212>  PRT
<213>  Pan troglodytes

<220>
<223>  GFRAL protein - Chimpanzee 

<400>  1832

Met Ile Val Phe Ile Phe Leu Ala Met Gly Leu Ser Leu Glu Asn Glu 
1               5                   10                  15      


Tyr Thr Ser Gln Thr Asn Asn Cys Thr Tyr Leu Arg Glu Gln Cys Leu 
            20                  25                  30          


Arg Asp Ala Asn Gly Cys Lys His Ala Trp Arg Val Met Glu Asp Ala 
        35                  40                  45              


Cys Asn Asp Ser Asp Pro Gly Asp Pro Cys Lys Met Arg Asn Ser Ser 
    50                  55                  60                  


Tyr Cys Asn Leu Ser Ile Gln Tyr Leu Val Glu Ser Asn Phe Gln Phe 
65                  70                  75                  80  


Lys Glu Cys Leu Cys Thr Asp Asp Phe Tyr Cys Thr Val Asn Lys Leu 
                85                  90                  95      


Leu Gly Lys Lys Cys Ile Asn Lys Ser Asp Asn Val Lys Glu Asp Lys 
            100                 105                 110         


Phe Lys Trp Asn Leu Thr Thr Arg Ser His His Gly Phe Lys Gly Met 
        115                 120                 125             


Trp Ser Cys Leu Glu Val Ala Glu Ala Cys Val Gly Asp Val Val Cys 
    130                 135                 140                 


Asn Ala Gln Leu Ala Ser Tyr Leu Lys Ala Cys Ser Ala Asn Gly Asn 
145                 150                 155                 160 


Pro Cys Asp Val Lys Gln Cys Gln Ala Ala Ile Arg Phe Phe Tyr Gln 
                165                 170                 175     


Asn Ile Pro Phe Asn Ile Ala Gln Met Leu Ala Phe Cys Asp Cys Ala 
            180                 185                 190         


Gln Ser Asp Ile Pro Cys Gln Gln Ser Lys Glu Ala Leu His Ser Lys 
        195                 200                 205             


Thr Cys Ala Val Asn Leu Val Pro Pro Pro Thr Cys Leu Ser Val Ile 
    210                 215                 220                 


Arg Ser Cys Gln Asn Asp Glu Leu Cys Arg Arg His Tyr Arg Thr Phe 
225                 230                 235                 240 


Gln Ser Lys Cys Trp Gln Arg Val Thr Arg Lys Cys His Glu Asp Glu 
                245                 250                 255     


Asn Cys Ile Ser Ala Leu Ser Lys Gln Asp Leu Thr Cys Ser Gly Ser 
            260                 265                 270         


Asp Asp Cys Lys Ala Ala Tyr Ile Asp Ile Leu Gly Thr Val Leu Gln 
        275                 280                 285             


Val Gln Cys Thr Cys Arg Thr Ile Thr Gln Ser Glu Glu Ser Leu Cys 
    290                 295                 300                 


Lys Ile Phe Gln His Met Leu His Arg Lys Ser Cys Phe Asn Tyr Pro 
305                 310                 315                 320 


Thr Leu Ser Asn Val Lys Gly Met Ala Leu Tyr Thr Arg Lys His Ala 
                325                 330                 335     


Asn Lys Ile Thr Leu Thr Gly Phe His Ser Pro Phe Asn Gly Glu Val 
            340                 345                 350         


Ile Tyr Ala Ala Met Cys Met Thr Val Thr Cys Gly Ile Leu Leu Leu 
        355                 360                 365             


Val Met Val Lys Leu Arg Thr Ser Arg Ile Ser Ser Lys Ala Arg Asp 
    370                 375                 380                 


Pro Ser Pro Ile Gln Ile Pro Gly Glu Leu 
385                 390                 


<210>  1833
<211>  395
<212>  PRT
<213>  Ailuropoda melanoleuca

<220>
<223>  GFRAL protein - Giant Panda 

<400>  1833

Met Val Val Phe Ile Phe Leu Ala Val Ala Leu Cys Leu Glu Asn Glu 
1               5                   10                  15      


Ser Thr Ser Glu Thr Ile Asp Cys Thr Tyr Leu Arg Glu Gln Cys Leu 
            20                  25                  30          


Arg Asp Ala Asn Gly Cys Lys His Ala Trp Arg Ile Met Glu Asp Ser 
        35                  40                  45              


Cys Asn Val Ser Glu Pro Gly Asn Pro Cys Lys Met Lys Asp Ser Ser 
    50                  55                  60                  


Lys Cys Asn Leu Ser Ile Gln Ser Leu Val Glu Ser Asn Phe Gln Phe 
65                  70                  75                  80  


Glu Asp Cys Leu Cys Thr Asp Asn Leu Tyr Cys Thr Ile Asn Lys Leu 
                85                  90                  95      


Leu Gly Glu Gln Cys Ile Asn Glu Ser Gly Asn Val Lys Glu Asp Asn 
            100                 105                 110         


Gln Ser Lys Trp Asn Leu Thr Thr Leu Pro Tyr Gln Gly Ile Lys Gly 
        115                 120                 125             


Ile Gln Ser Cys Leu Glu Val Ala Glu Ala Cys Val Gly Asp Val Val 
    130                 135                 140                 


Cys Asn Ala Gln Leu Ala Pro Tyr Leu Lys Ala Cys Ser Ala Asn Gly 
145                 150                 155                 160 


Asn Leu Cys Asp Val Lys His Cys Gln Ala Ala Ile Arg Phe Phe Tyr 
                165                 170                 175     


Gln Asn Met Pro Phe Asn Ile Ala Gln Met Leu Ala Phe Cys Asp Cys 
            180                 185                 190         


Ala Gln Ser Asp Ile Pro Cys Gln Gln Ser Arg Glu Ala Leu His Ser 
        195                 200                 205             


Lys Pro Cys Ala Val Asn Val Val Pro Pro Pro Thr Cys Leu Asp Val 
    210                 215                 220                 


Ile His Ser Cys Arg Asn Asp Glu Leu Cys Arg Arg Arg Tyr Arg Thr 
225                 230                 235                 240 


Phe Gln Ser Lys Cys Trp Gln His Val Thr Arg Lys Cys His Glu Asp 
                245                 250                 255     


Glu Leu Cys Ile Ser Thr Leu Ser Gln Gln Asp Leu Ile Cys Ser Gly 
            260                 265                 270         


Ser Asp Asp Cys Lys Ala Ala Tyr Ile Gly Thr Phe Gly Thr Val Leu 
        275                 280                 285             


Gln Val Gln Cys Thr Cys Arg Thr Ile Thr Gln Ser Glu Glu Ser Leu 
    290                 295                 300                 


Cys Lys Ile Phe Gln His Met Leu His Arg Arg Ser Cys Phe Asp Tyr 
305                 310                 315                 320 


Leu Thr Leu Ser Asn Val Lys Gly Met Ala Leu His Lys Arg Lys Pro 
                325                 330                 335     


Ala Lys Glu Ile Thr Leu Ser Gly Phe His Ser Pro Phe Asn Gly Glu 
            340                 345                 350         


Val Ile Tyr Ala Val Met Cys Met Thr Val Thr Cys Gly Ile Leu Leu 
        355                 360                 365             


Leu Val Met Leu Lys Leu Arg Thr Ser Arg Ile Ser Ser Gln Thr Arg 
    370                 375                 380                 


Asp His Ser Pro Ile Arg Ile Pro Gly Gly Leu 
385                 390                 395 


<210>  1834
<211>  395
<212>  PRT
<213>  Canis familiaris

<220>
<223>  GFRAL protein - Dog 

<400>  1834

Met Ile Val Phe Ile Phe Leu Ala Met Val Leu Cys Leu Glu Asn Glu 
1               5                   10                  15      


Ser Thr Ser Gln Thr Ile Asp Cys Thr His Leu Arg Glu Gln Cys Leu 
            20                  25                  30          


Ser Asp Ala Asp Gly Cys Lys His Ala Trp Arg Ile Met Glu Tyr Ser 
        35                  40                  45              


Cys Asn Val Ser Val Pro Gly Asn Pro Cys Lys Met Lys Asp Ser Ser 
    50                  55                  60                  


Asn Cys Asn Leu Ser Ile Gln Ser Leu Val Glu Asn Asn Phe Gln Phe 
65                  70                  75                  80  


Glu Asp Cys Leu Cys Thr Asp Asn Ile Tyr Cys Thr Ile Asn Lys Leu 
                85                  90                  95      


Leu Gly Glu Gln Cys Met Asn Glu Ser Asp Asn Met Lys Glu Asp Asn 
            100                 105                 110         


Gln Tyr Lys Trp Asn Leu Thr Thr Leu Pro Tyr His Gly Ile Lys Gly 
        115                 120                 125             


Ile Gln Ser Cys Leu Glu Val Ala Glu Ala Cys Val Gly Asp Val Val 
    130                 135                 140                 


Cys Asn Thr Gln Leu Ala Ala Tyr Leu Lys Ala Cys Ser Ala Asn Gly 
145                 150                 155                 160 


Asn Leu Cys Asp Val Lys His Cys Gln Ala Ala Ile Arg Phe Phe Tyr 
                165                 170                 175     


Gln Asn Met Pro Phe Asn Ile Ala Gln Met Leu Ala Phe Cys Asp Cys 
            180                 185                 190         


Ala Pro Ser Asp Ile Pro Cys Gln Gln Ser Lys Glu Ala Leu His Ser 
        195                 200                 205             


Lys Pro Cys Ala Val Asn Val Val Pro Pro Pro Ser Cys Leu Asp Val 
    210                 215                 220                 


Ile His Ser Cys Arg Asn Asp Glu Leu Cys Arg Arg Arg Tyr Arg Thr 
225                 230                 235                 240 


Phe Gln Ser Lys Cys Trp Gln His Met Ile Arg Lys Cys His Glu Asp 
                245                 250                 255     


Glu Leu Cys Ile Ser Thr Leu Ser Gln Gln Asp Leu Thr Cys Ser Gly 
            260                 265                 270         


Ser Asp Asp Cys Lys Ala Ala Tyr Ile Gly Thr Phe Gly Thr Val Leu 
        275                 280                 285             


Gln Val Gln Cys Thr Cys Arg Thr Thr Thr Gln Asn Glu Glu Ser Leu 
    290                 295                 300                 


Cys Lys Ile Phe Gln His Met Leu His Gly Arg Ser Cys Phe Asp Tyr 
305                 310                 315                 320 


Pro Thr Leu Ser Asn Val Lys Gly Met Ala Leu His Glu Arg Lys His 
                325                 330                 335     


Ala Lys Glu Ile Thr Leu Ser Gly Phe His Ser Pro Phe Asn Gly Glu 
            340                 345                 350         


Val Ile Tyr Ala Val Met Cys Met Thr Val Thr Cys Gly Ile Leu Leu 
        355                 360                 365             


Leu Val Met Leu Lys Leu Arg Thr Ser Arg Ile Ser Ser Gln Thr Arg 
    370                 375                 380                 


Asp His Ser Pro Ile Gln Ile Pro Gly Gly Leu 
385                 390                 395 


<210>  1835
<211>  395
<212>  PRT
<213>  Felis catus

<220>
<223>  GFRAL protein - Cat 

<400>  1835

Ser Val Leu Ile Val Ile Ser Ala Met Val Leu Cys Leu Glu Asn Glu 
1               5                   10                  15      


Ser Thr Ser Gln Thr Ile Asp Cys Thr Tyr Leu Arg Glu Gln Cys Leu 
            20                  25                  30          


Ser Asp Thr Asn Gly Cys Lys Leu Ala Trp Arg Lys Met Glu Asp Ser 
        35                  40                  45              


Cys Asn Val Ser Asp Pro Gly Asn Pro Cys Lys Met Lys Asp Ser Ser 
    50                  55                  60                  


Asn Cys Asn Leu Ser Ile Gln Ser Leu Val Glu Asn Asn Phe Gln Phe 
65                  70                  75                  80  


Glu Asp Cys Leu Cys Thr Gly Asn Leu His Cys Thr Ile Asn Lys Leu 
                85                  90                  95      


Leu Gly Lys Lys Cys Ile Asn Glu Ser Asp Asn Met Lys Glu Asp Asn 
            100                 105                 110         


Gln Ser Lys Trp Asn Leu Thr Thr Leu Pro Tyr Asn Gly Ile Lys Gly 
        115                 120                 125             


Ile Gln Ser Cys Leu Glu Val Ala Glu Ala Cys Val Gly Asp Val Val 
    130                 135                 140                 


Cys Asn Ala Gln Leu Ala Pro Tyr Leu Lys Ala Cys Ser Ala Asn Gly 
145                 150                 155                 160 


Asn Leu Cys Asp Val Lys His Cys Gln Ala Ala Ile Arg Phe Phe Tyr 
                165                 170                 175     


Gln Ser Met Pro Phe Asn Ile Ala Gln Met Leu Ala Phe Cys Asp Cys 
            180                 185                 190         


Ala Pro Ser Asp Ile Pro Cys Gln Gln Ser Lys Glu Ala Leu His Ser 
        195                 200                 205             


Lys Pro Cys Ala Val Asn Ile Val Pro Pro Pro Thr Cys Leu Asn Val 
    210                 215                 220                 


Ile His Ser Cys Arg Asn Asp Glu Leu Cys Arg Arg Arg Tyr Arg Thr 
225                 230                 235                 240 


Phe Gln Trp Lys Cys Trp Gln Gln Val Thr Arg Lys Cys His Glu Asp 
                245                 250                 255     


Glu Phe Cys Ile Ser Thr Leu Ser Lys Gln Asp Leu Thr Cys Ser Gly 
            260                 265                 270         


Ser Asp Asp Cys Lys Ala Ala Tyr Ile Gly Ile Leu Gly Thr Val Leu 
        275                 280                 285             


Gln Ala Gln Cys Thr Cys Arg Thr Ile Thr Gln Gly Glu Glu Ser Leu 
    290                 295                 300                 


Cys Lys Ile Phe Gln His Met Leu His Arg Arg Ser Cys Phe Asn Tyr 
305                 310                 315                 320 


Pro Thr Leu Ser Asn Val Lys Gly Ile Ala Leu His Lys Arg Lys His 
                325                 330                 335     


Ala Lys Glu Ile Thr Leu Ser Gly Phe His Ser Pro Phe Asn Gly Glu 
            340                 345                 350         


Val Ile Tyr Ala Val Met Cys Met Thr Val Thr Cys Gly Ile Leu Leu 
        355                 360                 365             


Leu Val Met Leu Lys Leu Arg Thr Ser Arg Ile Ser Ser Gln Thr Arg 
    370                 375                 380                 


Asp His Ser Pro Val Gln Ile Leu Glu Glu Leu 
385                 390                 395 


<210>  1836
<211>  324
<212>  PRT
<213>  Bos taurus

<220>
<223>  GFRAL protein - Bovine 

<400>  1836

Pro Leu Ile Val Val Ile Gln Ala Val Gly Leu Cys Leu Asn Lys Ser 
1               5                   10                  15      


Ala Ser Gln Thr Thr Asp Cys Thr Tyr Leu Arg Glu Leu Cys Leu Ser 
            20                  25                  30          


Asp Ala Asp Gly Cys Lys His Ala Trp Arg Ile Met Glu Asp Ala Cys 
        35                  40                  45              


Asn Val Ser Gly Asn Thr Cys Gln Met Lys Asn Ser Ser Ser Cys Gly 
    50                  55                  60                  


Leu Ser Ile Gln Ser Leu Val Glu Ser Asn Leu Gln Phe Lys Asp Cys 
65                  70                  75                  80  


Leu Cys Phe Asp Asp Leu Tyr Cys Thr Phe Asn Lys Leu Leu Gly Lys 
                85                  90                  95      


Lys Cys Ile Asn Glu Ser Asp Asn Ile Lys Glu Asp Asn Lys Tyr Lys 
            100                 105                 110         


Trp Asn Leu Thr Thr Leu Ser Tyr His Gly Gly Arg Gly Val Gln Ser 
        115                 120                 125             


Cys Leu Glu Val Ala Glu Val Cys Ile Gly Asp Ala Leu Cys Asn Ala 
    130                 135                 140                 


Gln Leu Ala Leu Tyr Leu Lys Ala Cys Ser Ala Asp Gly Lys Leu Cys 
145                 150                 155                 160 


Asp Val Lys His Cys Gln Ala Ala Ile Arg Phe Phe Tyr Gln Asn Met 
                165                 170                 175     


Pro Phe Asn Ile Ala Gln Met Leu Ala Phe Cys Asp Cys Ala Pro Ala 
            180                 185                 190         


Asp Glu Pro Cys Gln Gln Ser Arg Glu Ala Leu His Ser Arg Pro Cys 
        195                 200                 205             


Ala Val Asn Arg Val Pro Thr Pro Thr Cys Leu Asp Val Ile His Ser 
    210                 215                 220                 


Cys Gln Asp Asp Glu Leu Cys Arg Arg Arg Tyr Arg Ile Phe Gln Ala 
225                 230                 235                 240 


Lys Cys Trp Gln His Val Met Arg Lys Cys His Glu Asp Glu Thr Cys 
                245                 250                 255     


Ile Gly Thr Leu Ser Lys Gln Asp Leu Ala Cys Ser Gly Ser Asp Asp 
            260                 265                 270         


Cys Lys Ala Ala Tyr Ile Gly Thr Leu Gly Thr Val Leu Gln Gly Gln 
        275                 280                 285             


Cys Thr Cys Arg Thr Ile Thr Gln Ser Glu Glu Ser Leu Cys Lys Thr 
    290                 295                 300                 


Phe Gln His Met Leu His Arg Lys Ser Cys Phe Asn Asn Lys Pro Thr 
305                 310                 315                 320 


Gln Asn Leu Lys 
                


<210>  1837
<211>  395
<212>  PRT
<213>  Sus scrofa

<220>
<223>  GFRAL protein - Pig 

<400>  1837

Ser Val Ile Ala Val Leu Gln Ala Val Gly Leu Tyr Leu Glu Asn Glu 
1               5                   10                  15      


Ser Thr Ser Gln Thr Thr Asp Cys Thr Tyr Leu Arg Glu Leu Cys Leu 
            20                  25                  30          


Asn Asp Thr Asp Gly Cys Lys Gln Ala Trp Arg Ile Met Glu Asp Ala 
        35                  40                  45              


Cys Asn Val Ser Asp Pro Gly Asn Thr Cys Gln Met Lys Asp Ser Ser 
    50                  55                  60                  


Ser Cys Asn Gln Ser Ile Gln Ser Leu Ala Glu Ser Asn Phe Gln Phe 
65                  70                  75                  80  


Lys Asp Cys Leu Cys Ser Asp Asp Leu Tyr Cys Thr Val Asn Asn Leu 
                85                  90                  95      


Ile Gly Lys Lys Cys Thr Asn Glu Ser Asp Asn Met Lys Glu Asp Gly 
            100                 105                 110         


Val Phe Lys Arg Asn Leu Thr Ala Pro Ser Tyr His Gly Ile Arg Gly 
        115                 120                 125             


Ile Gln Ser Cys Leu Glu Val Ala Glu Ala Cys Val Arg Asp Thr Val 
    130                 135                 140                 


Cys Asn Ala Gln Leu Ala Leu Tyr Leu Lys Ala Cys Ser Ala Asn Gly 
145                 150                 155                 160 


Asn Leu Cys Asp Val Lys His Cys Gln Ala Ala Ile Arg Phe Phe Tyr 
                165                 170                 175     


Gln Asn Met Pro Phe Asn Val Ala Gln Met Leu Ala Phe Cys Asp Cys 
            180                 185                 190         


Ala Pro Ser Asp Ile Pro Cys Gln Gln Ser Lys Glu Ala Leu His Ser 
        195                 200                 205             


Lys Pro Cys Ala Leu Asn Arg Val Pro Ala Pro Thr Cys Leu Asp Val 
    210                 215                 220                 


Ile Arg Ser Cys Gln Asn Asp Glu Leu Cys Arg Arg Arg Tyr Arg Ile 
225                 230                 235                 240 


Phe Gln Ala Lys Cys Trp Gln His Val Thr Ala Lys Cys His Asp Asp 
                245                 250                 255     


Glu Thr Cys Ile Ser Thr Leu Asn Lys Gln Asp Phe Thr Cys Ser Arg 
            260                 265                 270         


Ser Asp Asp Cys Lys Ala Ala Tyr Met Gly Thr Leu Gly Thr Ala Leu 
        275                 280                 285             


Gln Gly Gln Cys Thr Cys Arg Thr Thr Thr Gln Ser Glu Glu Ser Leu 
    290                 295                 300                 


Cys Lys Ile Phe Gln His Met Leu His Gly Lys Ser Cys Phe Asn Tyr 
305                 310                 315                 320 


Pro Thr Leu Ser Asn Val Lys Gly Ile Ala Leu His Lys Arg Lys His 
                325                 330                 335     


Ala Lys Glu Ile Ser Leu Ser Gly Cys Gln Ser Pro Phe Asn Gly Glu 
            340                 345                 350         


Val Ile Tyr Ala Val Met Cys Met Thr Val Thr Cys Gly Ile Leu Leu 
        355                 360                 365             


Leu Val Met Phe Lys Leu Arg Asn Phe Arg Ile Ser Ser Gln Thr Arg 
    370                 375                 380                 


Asp Pro Ser Pro Ile Gln Ile Pro Gly Glu Pro 
385                 390                 395 


<210>  1838
<211>  220
<212>  PRT
<213>  Cricetulus griseus

<220>
<223>  GFRAL protein - Chinese Hamster (amino acids 169-388)

<400>  1838

Ala Cys Ser Ala Asn Gly Asn Leu Cys Asp Val Lys His Cys Gln Ala 
1               5                   10                  15      


Ala Ile Arg Phe Phe Tyr Gln Asn Met Pro Phe Asn Thr Ala Gln Met 
            20                  25                  30          


Leu Ala Phe Cys Asp Cys Ala Gln Ser Asp Ile Pro Cys Gln Gln Ser 
        35                  40                  45              


Lys Glu Thr Leu His Ser Lys Pro Cys Ala Leu Asn Val Val Pro Pro 
    50                  55                  60                  


Pro Thr Cys Leu Ser Val Ile His Thr Cys Arg Asn Asp Glu Leu Cys 
65                  70                  75                  80  


Arg Thr Arg Tyr Gln Thr Phe Gln Ser Glu Cys Trp Phe His Val Met 
                85                  90                  95      


Gly Lys Cys His Glu Asp Glu Thr Cys Ile Gly Thr Leu Gly Lys Gln 
            100                 105                 110         


Asp Leu Ile Cys Ser Gly Ser Asp Ser Cys Arg Ala Ala Tyr Leu Gly 
        115                 120                 125             


Thr Phe Gly Thr Val Leu Gln Val Pro Cys Ala Cys Arg Ser Ile Thr 
    130                 135                 140                 


Gln Asp Glu Glu Pro Leu Cys Met Thr Phe Gln His Met Leu Gln Ser 
145                 150                 155                 160 


Lys Ser Cys Phe Asn Tyr Pro Thr Pro Asn Val Lys Asp Ile Ser Ser 
                165                 170                 175     


Tyr Lys Gly Lys His Ser Lys Glu Ile Thr Leu Thr Gly Phe Glu Ser 
            180                 185                 190         


Pro Phe Asn Gly Glu Leu Val Tyr Ala Val Leu Cys Met Val Val Thr 
        195                 200                 205             


Cys Gly Ile Leu Phe Leu Val Met Leu Lys Leu Arg 
    210                 215                 220 


<210>  1839
<211>  319
<212>  PRT
<213>  Ornithorhynchus anatinus

<220>
<223>  GFRAL protein - Platypus 

<400>  1839

Met Lys His Tyr Phe Leu Phe Val Val Leu Met Leu Gly Phe Lys Cys 
1               5                   10                  15      


Glu Ser Ala Ser Leu Thr Thr Gly Cys Leu His Leu Arg Lys Gln Cys 
            20                  25                  30          


Val Ser Ala Met Asp Gly Cys Glu Ser Ala Trp Ala Val Ile Glu Asp 
        35                  40                  45              


Val Cys Asn Val Ser Gly His Asn Cys Thr Met Lys Glu Ser Leu Asn 
    50                  55                  60                  


Cys Asn Leu Ser Ile Gln Leu Leu Ala Asp Arg Tyr Pro Ala Phe Lys 
65                  70                  75                  80  


Asp Cys Leu Cys Ala Glu Asp Ile Ser Cys Ser Ala Thr Asn Phe Leu 
                85                  90                  95      


Gly Arg Lys Cys Ile Ile Lys Thr Glu Asn Glu His Lys Asp Lys Asn 
            100                 105                 110         


Ile Lys Ser Leu Trp Asn Ser Thr Ser Leu Leu Gln His Gly Phe Lys 
        115                 120                 125             


Gly Thr Arg Ser Cys Leu Glu Val Thr Val Ala Cys Val Gly Asp Thr 
    130                 135                 140                 


Val Cys Asn Lys Gln Leu Ala Arg Phe Leu Lys Asp Cys Ser Thr His 
145                 150                 155                 160 


Gly Ser Leu Cys Asn Met Asn Gln Cys Gln Ala Ala Ile Arg Phe Phe 
                165                 170                 175     


Tyr Gln Asn Ile Pro Phe Asn Ile Ala Gln Met Leu Ala Phe Cys Asp 
            180                 185                 190         


Cys Ala Gln Ser Asp Ile Pro Cys Gln Gln Ser Lys Glu Ala Leu His 
        195                 200                 205             


Ser Lys Pro Cys Ala Val Asn Val Val Pro Thr Pro Ser Cys Leu Asn 
    210                 215                 220                 


Val Ile Arg Ser Cys Arg Asp Asp Glu Leu Cys Arg Gln Arg Phe Glu 
225                 230                 235                 240 


Thr Phe Gln Ser Lys Cys Trp Gln Asp Met Asp Lys Cys Ser Asp Asp 
                245                 250                 255     


Glu Thr Cys Ile Val Thr Leu Asn Lys Glu Asn Ile Thr Cys Ser Arg 
            260                 265                 270         


Asn Glu Glu Cys Arg Glu Ala Tyr Ile Gly Thr Leu Gly Thr Tyr Leu 
        275                 280                 285             


His Val Gln Cys Thr Cys Ser Thr Leu Ser Leu Thr Glu Glu Tyr Leu 
    290                 295                 300                 


Cys Lys Ile Phe His His Ile Leu His Ser Arg Ser Cys Phe Ser 
305                 310                 315                 


<210>  1840
<211>  168
<212>  PRT
<213>  Cricetulus griseus

<220>
<223>  GFRAL protein - Chinese Hamster (amino acids 1-168)

<400>  1840

Met Asp Val Leu Leu Asn His Ser Phe Thr Ser Phe Ile Glu Glu Ser 
1               5                   10                  15      


Thr Leu Pro Ser Asp Leu Val Pro Arg Ser Asn Val Thr Gln Gly Phe 
            20                  25                  30          


Leu Arg Glu Asp Thr Phe Leu Thr Ala Glu Arg Lys Asp Asp Cys Val 
        35                  40                  45              


Ala Ala Ala Glu Ala Cys Gln Glu Ser Val His Cys Ser Leu Leu His 
    50                  55                  60                  


Glu Asn Phe Lys Lys Ala Cys Gly Lys Gly Thr Ala Gln Cys His Thr 
65                  70                  75                  80  


Leu Ser Gly Gln Gln Phe Cys Val Ala Leu Arg Glu Ser Leu Arg Glu 
                85                  90                  95      


Thr Val Leu Trp Asp Cys Gln Cys Gly Phe Pro Leu Glu Gly Asp Cys 
            100                 105                 110         


Ile Arg Ile Trp Lys Gly Leu Phe Glu Asp Ile Cys Ile Glu Asp Thr 
        115                 120                 125             


Gln Ile Asn Gln Ile Ala Thr Phe Ser Gln Asp Asn Glu Asp Arg Leu 
    130                 135                 140                 


Lys Glu Asp Ile Ala Ser Asp Asn Leu Lys Lys Asp Asn Lys Phe Lys 
145                 150                 155                 160 


Trp Asp Leu Thr Thr Leu His His 
                165             


<210>  1841
<211>  308
<212>  PRT
<213>  Macaca mulatta

<220>
<223>  GDF15 protein - Rhesus Monkey 

<400>  1841

Met Pro Gly Gln Glu Leu Lys Thr Leu Asn Gly Ser Gln Met Leu Leu 
1               5                   10                  15      


Val Leu Leu Val Leu Leu Trp Pro Pro His Gly Gly Ala Met Ser Leu 
            20                  25                  30          


Ala Glu Ala Ser Arg Ala Ser Phe Pro Gly Pro Ser Asp Leu His Ser 
        35                  40                  45              


Glu Asp Ser Arg Phe Arg Glu Leu Arg Lys Arg Tyr Glu Asp Leu Leu 
    50                  55                  60                  


Thr Arg Leu Arg Ala Asn Gln Ser Trp Glu Asp Ser Asn Thr Asp Leu 
65                  70                  75                  80  


Ile Gln Ala Pro Glu Val Arg Ile Leu Thr Pro Glu Val Arg Leu Gly 
                85                  90                  95      


Ser Gly Gly His Leu His Leu Arg Ile Ser Arg Ala Val Leu Pro Glu 
            100                 105                 110         


Gly Leu Pro Glu Ala Ser Arg Ile His Arg Ala Leu Phe Arg Leu Ser 
        115                 120                 125             


Pro Thr Ala Ser Arg Ser Trp Asp Val Thr Arg Pro Leu Arg Arg Gln 
    130                 135                 140                 


Leu Arg Leu Ala Arg Pro Gln Ala Pro Ala Leu His Leu Arg Leu Ser 
145                 150                 155                 160 


Pro Pro Pro Ser Gln Ser Asp Gln Leu Leu Val Lys Ser Ser Ser Ser 
                165                 170                 175     


Arg Pro Gln Leu Glu Leu His Leu Arg Leu Arg Ala Ala Arg Gly Arg 
            180                 185                 190         


Arg Arg Ala Arg Ala Arg Asn Gly Asp Arg Cys Pro Leu Gly Pro Gly 
        195                 200                 205             


Arg Cys Cys Arg Leu His Thr Val His Ala Ser Leu Glu Asp Leu Gly 
    210                 215                 220                 


Trp Ala Asp Trp Val Leu Ser Pro Arg Glu Val Gln Val Thr Met Cys 
225                 230                 235                 240 


Ile Gly Ala Cys Pro Ser Gln Phe Arg Glu Ala Asn Met His Ala Gln 
                245                 250                 255     


Ile Lys Met Asn Leu His Arg Leu Lys Pro Asp Thr Val Pro Ala Pro 
            260                 265                 270         


Cys Cys Val Pro Ala Ser Tyr Asn Pro Met Val Leu Ile Gln Lys Thr 
        275                 280                 285             


Asp Thr Gly Val Ser Leu Gln Thr Tyr Asp Asp Leu Leu Ala Lys Asp 
    290                 295                 300                 


Cys His Cys Val 
305             


<210>  1842
<211>  308
<212>  PRT
<213>  Hylobates sp.

<220>
<223>  GDF15 protein - Gibbon 

<400>  1842

Met Pro Arg Gln Glu Pro Arg Met Leu Asn Gly Ser Gln Met Leu Leu 
1               5                   10                  15      


Val Leu Leu Val Leu Ser Trp Pro Pro His Gly Gly Ala Leu Ser Leu 
            20                  25                  30          


Ala Glu Ala Ser Pro Ala Ser Phe Pro Gly Pro Ser Glu Leu His Ser 
        35                  40                  45              


Lys Asp Ser Arg Phe Arg Glu Leu Arg Lys Arg Tyr Glu Asp Leu Leu 
    50                  55                  60                  


Thr Arg Leu Arg Val Asn Gln Ser Trp Glu Asp Leu Asn Thr Asp Leu 
65                  70                  75                  80  


Val Pro Ala Pro Ala Val Arg Ile Leu Thr Pro Glu Val Arg Leu Gly 
                85                  90                  95      


Ser Gly Gly His Leu His Leu Arg Ile Ser Arg Ala Ala Leu Pro Glu 
            100                 105                 110         


Gly Leu Pro Glu Ala Ser Arg Leu His Arg Ala Leu Phe Arg Leu Ser 
        115                 120                 125             


Pro Thr Ala Ser Arg Ser Trp Asp Val Thr Arg Pro Leu Arg Arg Gln 
    130                 135                 140                 


Leu Ser Leu Ala Arg Pro Gln Ala Pro Ala Leu His Leu Arg Leu Ser 
145                 150                 155                 160 


Pro Pro Arg Ser Arg Ser Asp Gln Leu Leu Ala Glu Ser Ser Ser Ala 
                165                 170                 175     


Arg Pro Gln Leu Glu Leu His Leu Arg Pro Gln Ala Ala Arg Gly Arg 
            180                 185                 190         


Arg Arg Ala Arg Ala Arg Asn Gly Asp His Cys Pro Leu Gly Pro Gly 
        195                 200                 205             


Arg Cys Cys Arg Leu His Thr Val Arg Ala Ser Leu Glu Asp Leu Gly 
    210                 215                 220                 


Trp Ala Asp Trp Val Leu Ser Pro Arg Glu Val Gln Val Thr Met Cys 
225                 230                 235                 240 


Ile Gly Ala Cys Pro Ser Gln Phe Arg Ala Ala Asn Met His Ala Gln 
                245                 250                 255     


Ile Lys Thr Ser Leu His Arg Leu Lys Pro Asp Thr Val Pro Ala Pro 
            260                 265                 270         


Cys Cys Val Pro Ala Ser Tyr Asn Pro Met Val Leu Ile Gln Lys Thr 
        275                 280                 285             


Asp Thr Gly Val Ser Leu Gln Thr Tyr Asp Asp Leu Leu Ala Lys Asp 
    290                 295                 300                 


Cys His Cys Ile 
305             


<210>  1843
<211>  308
<212>  PRT
<213>  Pan troglodytes

<220>
<223>  GDF15 protein - Chimpanzee 

<400>  1843

Met Pro Arg Gln Glu Leu Arg Thr Leu Asn Gly Ser Gln Met Leu Leu 
1               5                   10                  15      


Val Leu Leu Val Leu Ser Trp Pro Pro His Gly Gly Ala Leu Ser Leu 
            20                  25                  30          


Ala Glu Ala Ser Arg Ala Ser Phe Ser Gly Pro Ser Glu Leu His Ser 
        35                  40                  45              


Glu Asp Ala Arg Phe Arg Glu Leu Arg Lys Arg Tyr Glu Asp Leu Leu 
    50                  55                  60                  


Thr Arg Leu Arg Ala Asn Gln Ser Trp Glu Asp Ser Asn Thr Asp Leu 
65                  70                  75                  80  


Val Pro Ala Pro Ala Val Arg Ile Leu Thr Pro Glu Val Arg Leu Gly 
                85                  90                  95      


Ser Gly Gly His Leu His Leu Arg Ile Ser Arg Ala Ala Leu Pro Glu 
            100                 105                 110         


Gly Leu Pro Glu Ala Ser Arg Leu His Arg Ala Leu Phe Arg Leu Ser 
        115                 120                 125             


Pro Thr Ala Ala Arg Ser Trp Asp Val Thr Arg Pro Leu Arg Arg Gln 
    130                 135                 140                 


Leu Ser Leu Ala Arg Pro Gln Ala Pro Ala Leu His Leu Arg Leu Ser 
145                 150                 155                 160 


Pro Pro Pro Ser Gln Ser Asp Gln Leu Leu Ala Glu Ser Ser Ser Ala 
                165                 170                 175     


Arg Pro Gln Leu Glu Leu His Leu Arg Ser Arg Ala Ala Arg Gly Leu 
            180                 185                 190         


Arg Arg Ala Arg Ala Arg Asn Gly Asp His Cys Pro Leu Gly Pro Gly 
        195                 200                 205             


Arg Cys Cys Arg Leu His Thr Val Arg Ala Ser Leu Glu Asp Leu Gly 
    210                 215                 220                 


Trp Ser Asp Trp Val Leu Ser Pro Arg Glu Val Gln Val Thr Met Cys 
225                 230                 235                 240 


Ile Gly Ala Cys Pro Ser Gln Phe Arg Ala Ala Asn Met His Ala Gln 
                245                 250                 255     


Ile Lys Thr Ser Leu His Arg Leu Lys Pro Asp Thr Val Pro Ala Pro 
            260                 265                 270         


Cys Cys Val Pro Ala Ser Tyr Asn Pro Met Val Leu Ile Gln Lys Thr 
        275                 280                 285             


Asp Thr Gly Val Ser Leu Gln Thr Tyr Asp Asp Leu Leu Ala Lys Asp 
    290                 295                 300                 


Cys His Cys Ile 
305             


<210>  1844
<211>  308
<212>  PRT
<213>  Pongo sp.

<220>
<223>  GDF15 protein - Orangutan

<400>  1844

Met Pro Arg Gln Glu Leu Arg Thr Leu Asn Gly Phe Gln Met Leu Leu 
1               5                   10                  15      


Val Leu Leu Val Leu Ser Trp Pro Pro His Gly Gly Ala Leu Ser Leu 
            20                  25                  30          


Ala Glu Ala Ser Arg Ala Ser Phe Pro Gly Pro Ser Asp Leu His Ser 
        35                  40                  45              


Glu Asp Ser Arg Phe Arg Glu Leu Arg Lys Arg Tyr Glu Asp Leu Leu 
    50                  55                  60                  


Thr Arg Leu Arg Ala Asn Gln Ser Trp Glu Asp Ser Asn Thr Asp Leu 
65                  70                  75                  80  


Val Pro Ala Pro Ala Val Arg Ile Leu Thr Pro Glu Val Arg Leu Gly 
                85                  90                  95      


Ser Gly Gly His Leu His Leu Arg Ile Ser Arg Ala Ala Leu Pro Glu 
            100                 105                 110         


Gly Leu Pro Glu Ala Ser Arg Leu His Arg Ala Leu Phe Arg Leu Ser 
        115                 120                 125             


Pro Thr Ala Ser Arg Ser Trp Asp Val Thr Arg Leu Leu Arg Arg Gln 
    130                 135                 140                 


Leu Ser Leu Ala Arg Pro Gln Ala Pro Ala Leu His Leu Arg Leu Ser 
145                 150                 155                 160 


Pro Pro Pro Ser Gln Ser Asp Gln Leu Leu Ala Glu Ser Ser Ser Ala 
                165                 170                 175     


Arg Pro Gln Leu Glu Leu His Leu Arg Pro Arg Ala Ala Arg Gly Arg 
            180                 185                 190         


Arg Arg Ala Arg Ala Arg Asn Gly Asp His Cys Pro Leu Gly Pro Gly 
        195                 200                 205             


Arg Cys Cys Arg Leu His Thr Val Arg Ala Ser Leu Glu Asp Leu Gly 
    210                 215                 220                 


Trp Ala Asp Trp Val Leu Ser Pro Arg Glu Val Gln Val Thr Met Cys 
225                 230                 235                 240 


Ile Gly Ala Cys Pro Ser Gln Phe Arg Ala Ala Asn Met His Ala Gln 
                245                 250                 255     


Ile Lys Thr Ser Leu His Arg Leu Lys Pro Asp Thr Val Pro Ala Pro 
            260                 265                 270         


Cys Cys Val Pro Ala Ser Tyr Asn Pro Met Val Leu Ile Gln Lys Thr 
        275                 280                 285             


Asp Thr Gly Val Ser Leu Gln Thr Tyr Asp Asp Leu Leu Ala Lys Asp 
    290                 295                 300                 


Cys His Cys Ile 
305             


<210>  1845
<211>  308
<212>  PRT
<213>  Bos taurus

<220>
<223>  GDF15 protein - Cow 

<400>  1845

Met Pro Gly Gln Arg Pro Ala Ala Pro His Arg Ser Arg Met Leu Leu 
1               5                   10                  15      


Met Leu Leu Met Phe Ser Trp Leu Arg Ser Gly Gly Ala Leu Ser Leu 
            20                  25                  30          


Thr Gln Glu His Leu Gln Thr Phe Gln Gly Pro Ser Asn Val His Ser 
        35                  40                  45              


Ser Pro Asp Ile Ser Arg Phe Arg Glu Leu Arg Lys Arg Tyr Glu Asp 
    50                  55                  60                  


Leu Leu Thr Arg Leu Arg Ala Asn Gln Thr Trp Glu Asp Ser Asn Pro 
65                  70                  75                  80  


Asp Leu Ile Pro Pro Pro Gln Val Arg Ile Val Thr Pro Lys Leu Arg 
                85                  90                  95      


Leu Gly Pro Gly Gly His Leu His Leu Arg Ile Pro Arg Val Asn Leu 
            100                 105                 110         


Thr Glu Gly Leu Pro Ala Ala Ser Arg Leu His Arg Ala Leu Leu Arg 
        115                 120                 125             


Leu Ser Pro Lys Ala Trp Ser Ser Trp Asp Val Thr Arg Pro Leu Arg 
    130                 135                 140                 


Arg Gln Leu Arg Leu Gly Gly Ser Arg Gly Pro Ser Ile Arg Leu Arg 
145                 150                 155                 160 


Leu Leu Ala Arg Pro Asp Gln Leu Gln Glu Ala Leu Pro Ser Ala Pro 
                165                 170                 175     


Pro Gln Leu Glu Leu His Trp Arg Pro Ser Ala Thr Arg Gly Arg Arg 
            180                 185                 190         


His Ala His Ala His Thr Arg Asp Gly Cys Pro Leu Gly Glu Gly Arg 
        195                 200                 205             


Cys Cys His Leu Gln Ser Leu Arg Ala Ser Leu Glu Asp Leu Gly Trp 
    210                 215                 220                 


Ala Asp Trp Val Leu Ala Pro Arg Glu Leu Asp Val Arg Met Cys Ile 
225                 230                 235                 240 


Gly Ala Cys Pro Ser His Phe Arg Ser Ala Asn Thr His Ala Gln Met 
                245                 250                 255     


Gln Ala Arg Leu His Gly Leu Asn Pro Asp Ala Ala Pro Ala Pro Cys 
            260                 265                 270         


Cys Val Pro Ala Ser Tyr Glu Pro Val Val Leu Met His Gln Asp Ser 
        275                 280                 285             


Asp Gly Arg Val Ser Leu Thr Pro Phe Asp Asp Leu Val Ala Lys Asp 
    290                 295                 300                 


Cys His Cys Val 
305             


<210>  1846
<211>  308
<212>  PRT
<213>  Sus scrofa

<220>
<223>  GDF15 protein - Pig 

<400>  1846

Met Pro Gly Gln Leu Pro Ser Pro Pro Arg Arg Ser Pro Thr Leu Leu 
1               5                   10                  15      


Met Leu Leu Met Leu Ser Trp Leu Pro Ser Gly Gly Ala Leu Ser Leu 
            20                  25                  30          


Ala Gln Glu His Leu Pro Ala Leu Pro Gly Pro Ser Asp Val His Ser 
        35                  40                  45              


Ser Ser Asp Val Ser Arg Phe Arg Glu Leu Arg Lys Arg Tyr Glu Asp 
    50                  55                  60                  


Leu Leu Thr Arg Leu Arg Ala Asn Gln Thr Trp Glu Asp Ser Asn Pro 
65                  70                  75                  80  


Asn Leu Ile Pro Ala Pro Gln Val Arg Ile Val Thr Pro Lys Phe Arg 
                85                  90                  95      


Leu Gly Pro Gly Gly His Leu His Leu Arg Ile Pro Arg Val Asn Leu 
            100                 105                 110         


Thr Glu Gly Leu Pro Ala Ala Ser Arg Leu His Arg Ala Leu Leu Arg 
        115                 120                 125             


Leu Ser Pro Thr Ala Arg Ser Ser Trp Asp Val Thr Arg Pro Leu Arg 
    130                 135                 140                 


Arg Gln Leu Ser Val Gly Gly Ser Arg Gly Ser Ala Ile His Leu Arg 
145                 150                 155                 160 


Leu Leu Gln Arg Pro Asp Gln Leu Leu Glu Ala Leu Pro Ala Gly Gln 
                165                 170                 175     


Pro Gln Leu Glu Leu His Trp Arg Pro Ser Ser Thr Arg Gly Arg Arg 
            180                 185                 190         


Asn Thr His Ala His Thr Arg Asp Gly Cys Pro Leu Gly Thr Gly Arg 
        195                 200                 205             


Cys Cys Arg Leu Gln Ser Leu Arg Ala Ser Leu Glu Asp Leu Gly Trp 
    210                 215                 220                 


Ala Asp Trp Val Leu Ala Pro Arg Glu Leu Asp Val Arg Met Cys Val 
225                 230                 235                 240 


Gly Ala Cys Pro Ser His Phe Arg Ser Ala Asn Thr His Ala Gln Met 
                245                 250                 255     


Gln Ala Arg Leu His Gly Leu Asn Pro Asp Ala Ala Pro Ala Pro Cys 
            260                 265                 270         


Cys Val Pro Ala Ser Tyr Glu Pro Val Val Leu Met His Gln Asp Ser 
        275                 280                 285             


Asp Gly Arg Val Ser Leu Thr Pro Phe Asp Asp Leu Val Ala Lys Asp 
    290                 295                 300                 


Cys His Cys Val 
305             


<210>  1847
<211>  307
<212>  PRT
<213>  Canis familiaris

<220>
<223>  GDF15 protein - Dog 

<400>  1847

Met Pro Gly Gln Gly Pro Ala Pro Ala His Cys Ser Pro Met Leu Val 
1               5                   10                  15      


Ile Leu Val Met Leu Ser Trp Leu Pro Ser Gly Gly Ala Leu Ser Leu 
            20                  25                  30          


Ala Gln Glu His Leu Pro Ala Phe Pro Gly Pro Ser Asp Pro His Ser 
        35                  40                  45              


Ser Thr Asp Val Ser Arg Ile Gln Glu Leu Arg Lys Arg Tyr Glu His 
    50                  55                  60                  


Leu Gln Thr Lys Leu Arg Leu Asn Gln Gly Trp Ala Asp Ser Asn Pro 
65                  70                  75                  80  


Asp Leu Val Pro Ala Thr Arg Val Arg Ile Leu Thr Pro Lys Leu Arg 
                85                  90                  95      


Leu Gly Pro Arg Gly His Leu His Leu Arg Ile Ala Arg Ala Asp Leu 
            100                 105                 110         


Thr Ala Gly Leu Pro Ala Ala Ser Arg Leu His Arg Ala Leu Leu Arg 
        115                 120                 125             


Leu Ser Pro Thr Glu Pro Ser Ser Trp Asp Val Thr Arg Pro Leu Gln 
    130                 135                 140                 


Arg Gln Leu Ser Arg Val Gly Ser Arg Thr Pro Thr Leu Arg Leu Arg 
145                 150                 155                 160 


Leu Leu Pro Arg Trp Asp Arg Ser Arg Ala Leu Pro Ser Ala Arg Pro 
                165                 170                 175     


Gln Leu Glu Leu His Trp Arg Pro Arg Ala Ala Arg Gly Arg Arg Asn 
            180                 185                 190         


Ala His Ala His Ala Arg Asp Gly Cys Pro Leu Gly Glu Gly Arg Cys 
        195                 200                 205             


Cys Arg Leu Gln Ser Leu Arg Ala Ser Leu Gln Asp Leu Gly Trp Ala 
    210                 215                 220                 


Asn Trp Val Val Ala Pro Arg Glu Leu Asp Val Arg Met Cys Val Gly 
225                 230                 235                 240 


Ala Cys Pro Ser Gln Phe Arg Ser Ala Asn Thr His Ala Gln Met Gln 
                245                 250                 255     


Ala Arg Leu His Gly Leu Asn Pro Asp Ala Ala Pro Ala Pro Cys Cys 
            260                 265                 270         


Val Pro Ala Ser Tyr Glu Pro Val Val Leu Met His Gln Asp Ser Asp 
        275                 280                 285             


Gly Arg Val Ser Leu Thr Pro Phe Asp Asp Leu Val Ala Lys Asp Cys 
    290                 295                 300                 


His Cys Val 
305         


<210>  1848
<211>  308
<212>  PRT
<213>  Ailuropoda melanoleuca

<220>
<223>  GDF15 protein - Giant Panda 

<400>  1848

Met Pro Gly Gln Gly Leu Thr Pro Pro Pro Gly Ser Pro Met Leu Leu 
1               5                   10                  15      


Met Leu Leu Met Phe Ser Trp Leu Pro Ser Gly Gly Ala Leu Ser Leu 
            20                  25                  30          


Ala Gln Glu His Leu Pro Ala Phe Pro Gly Pro Ser Asp Thr His Ser 
        35                  40                  45              


Ser Thr Asp Val Ser Arg Ala Gln Glu Phe Arg Lys Arg Tyr Ala His 
    50                  55                  60                  


Leu Gln Thr Arg Leu Trp Leu Asn Gln Ser Arg Ala Asp Ser Asn Ser 
65                  70                  75                  80  


Asp Leu Ile Pro Ala Ala Gln Val Arg Ile Leu Thr Pro Lys Leu Arg 
                85                  90                  95      


Leu Gly Ser Gly Gly His Leu His Leu Arg Ile Ala Arg Ala Asp Leu 
            100                 105                 110         


Thr Glu Gly Leu Pro Ala Ala Ser Arg Leu His Arg Ala Leu Leu Arg 
        115                 120                 125             


Leu Ser Pro Thr Glu Pro Ser Ser Trp Asp Val Thr Arg Pro Leu Gln 
    130                 135                 140                 


Arg Gln Leu Ser Leu Gly Gly Ser Arg Ala Pro Val Leu Arg Leu Arg 
145                 150                 155                 160 


Leu Leu Pro Gln Trp Asp Pro Leu Gly Ala Thr Leu Pro Ser Ala Arg 
                165                 170                 175     


Pro Gln Leu Glu Leu His Trp Arg Pro Arg Ala Ala Arg Gly Arg Arg 
            180                 185                 190         


Asn Ala His Ala His Gly Gly Asp Gly Cys Pro Leu Gly Glu Gly Arg 
        195                 200                 205             


Cys Cys Arg Leu Gln Ser Leu Arg Ala Ser Leu Glu Asp Leu Gly Trp 
    210                 215                 220                 


Ala Asp Trp Val Val Ala Pro Arg Glu Leu Asp Val Arg Met Cys Val 
225                 230                 235                 240 


Gly Ala Cys Pro Ser Gln Phe Arg Ser Ala Asn Thr His Ala Gln Met 
                245                 250                 255     


Gln Ala Arg Leu His Gly Leu Asn Pro Glu Ala Ala Pro Ala Pro Cys 
            260                 265                 270         


Cys Val Pro Ala Ser Tyr Glu Pro Val Val Leu Met His Gln Asp Ser 
        275                 280                 285             


Asp Gly Arg Val Ser Leu Thr Pro Phe Asp Asp Leu Val Ala Lys Asp 
    290                 295                 300                 


Cys His Cys Val 
305             


<210>  1849
<211>  298
<212>  PRT
<213>  Mustela furo

<220>
<223>  GDF15 protein - Ferret 

<400>  1849

His Ser Ser Pro Met Leu Pro Val Leu Leu Met Phe Ser Trp Leu Pro 
1               5                   10                  15      


Ser Gly Gly Ala Leu Ser Leu Ala Gln Glu Arg Leu Pro Ala Phe Pro 
            20                  25                  30          


Gly Pro Ser Asp Ala His Ser Ser Met Asp Ile Ser Arg Ala Gln Glu 
        35                  40                  45              


Phe Arg Lys His Tyr Glu His Leu Gln Thr Arg Leu Arg Leu Asn Gln 
    50                  55                  60                  


Ser Trp Gly Asp Ser Asn Ser Asp Leu Asn Leu Thr Ala Pro Val Arg 
65                  70                  75                  80  


Ile Leu Thr Pro Lys Leu Arg Leu Gly Pro Gly Gly His Leu His Leu 
                85                  90                  95      


Arg Ile Ala Leu Ala Asp Leu Thr Glu Gly Leu Pro Ala Thr Ser Arg 
            100                 105                 110         


Leu His Gln Ala Leu Leu Arg Leu Ser Pro Met Glu Pro Ser Ser Trp 
        115                 120                 125             


Asp Val Thr Arg Pro Leu Gln Arg Gln Leu Ser Leu Gly Gly Ser Arg 
    130                 135                 140                 


Ala Ser Ala Leu His Leu Arg Leu Leu Pro Arg Leu Asn Arg Leu Arg 
145                 150                 155                 160 


Ala Thr Leu Pro Ser Ala Arg Pro Gln Leu Glu Leu His Trp Arg Pro 
                165                 170                 175     


Ser Ala Ala Arg Gly Arg Arg Asp Ala His Ala His Ala Gly Asp Gly 
            180                 185                 190         


Cys Pro Leu Gly Glu Gly Arg Cys Cys Arg Leu Gln Ser Leu Arg Ala 
        195                 200                 205             


Ser Leu Glu Asp Leu Gly Trp Ala Asn Trp Val Val Ala Pro Arg Glu 
    210                 215                 220                 


Leu Asp Val Arg Met Cys Ile Gly Ala Cys Pro Ser Gln Phe Arg Ser 
225                 230                 235                 240 


Ala Asn Thr His Ala Gln Met Gln Ala Arg Leu His Gly Leu Asn Pro 
                245                 250                 255     


Asp Ala Ala Pro Ala Pro Cys Cys Val Pro Ala Ser Tyr Glu Pro Val 
            260                 265                 270         


Val Leu Leu His Gln Asp Ser Asp Gly Arg Val Ser Leu Thr Pro Phe 
        275                 280                 285             


Asp Asp Leu Val Ala Lys Asp Cys His Cys 
    290                 295             


<210>  1850
<211>  303
<212>  PRT
<213>  Mus musculus

<220>
<223>  GDF15 protein - Mouse

<400>  1850

Met Ala Pro Pro Ala Leu Gln Ala Gln Pro Pro Gly Gly Ser Gln Leu 
1               5                   10                  15      


Arg Phe Leu Leu Phe Leu Leu Leu Leu Leu Leu Leu Leu Ser Trp Pro 
            20                  25                  30          


Ser Gln Gly Asp Ala Leu Ala Met Pro Glu Gln Arg Pro Ser Gly Pro 
        35                  40                  45              


Glu Ser Gln Leu Asn Ala Asp Glu Leu Arg Gly Arg Phe Gln Asp Leu 
    50                  55                  60                  


Leu Ser Arg Leu His Ala Asn Gln Ser Arg Glu Asp Ser Asn Ser Glu 
65                  70                  75                  80  


Pro Ser Pro Asp Pro Ala Val Arg Ile Leu Ser Pro Glu Val Arg Leu 
                85                  90                  95      


Gly Ser His Gly Gln Leu Leu Leu Arg Val Asn Arg Ala Ser Leu Ser 
            100                 105                 110         


Gln Gly Leu Pro Glu Ala Tyr Arg Val His Arg Ala Leu Leu Leu Leu 
        115                 120                 125             


Thr Pro Thr Ala Arg Pro Trp Asp Ile Thr Arg Pro Leu Lys Arg Ala 
    130                 135                 140                 


Leu Ser Leu Arg Gly Pro Arg Ala Pro Ala Leu Arg Leu Arg Leu Thr 
145                 150                 155                 160 


Pro Pro Pro Asp Leu Ala Met Leu Pro Ser Gly Gly Thr Gln Leu Glu 
                165                 170                 175     


Leu Arg Leu Arg Val Ala Ala Gly Arg Gly Arg Arg Ser Ala His Ala 
            180                 185                 190         


His Pro Arg Asp Ser Cys Pro Leu Gly Pro Gly Arg Cys Cys His Leu 
        195                 200                 205             


Glu Thr Val Gln Ala Thr Leu Glu Asp Leu Gly Trp Ser Asp Trp Val 
    210                 215                 220                 


Leu Ser Pro Arg Gln Leu Gln Leu Ser Met Cys Val Gly Glu Cys Pro 
225                 230                 235                 240 


His Leu Tyr Arg Ser Ala Asn Thr His Ala Gln Ile Lys Ala Arg Leu 
                245                 250                 255     


His Gly Leu Gln Pro Asp Lys Val Pro Ala Pro Cys Cys Val Pro Ser 
            260                 265                 270         


Ser Tyr Thr Pro Val Val Leu Met His Arg Thr Asp Ser Gly Val Ser 
        275                 280                 285             


Leu Gln Thr Tyr Asp Asp Leu Val Ala Arg Gly Cys His Cys Ala 
    290                 295                 300             


<210>  1851
<211>  301
<212>  PRT
<213>  Cavia porcellus

<220>
<223>  GDF15 protein - Guinea Pig 

<400>  1851

Met Pro Ala Leu Gly Phe Thr Leu Leu Leu Leu Ala Ala Val Ser Arg 
1               5                   10                  15      


Pro Pro Pro Gly Gly Ala Ser Gly Pro Ala Glu Lys Leu Pro Ala Glu 
            20                  25                  30          


Pro Asp Pro Asp Leu Asp Pro Asp Arg Asp Pro Asp Pro Ala Ala His 
        35                  40                  45              


Pro Ala Arg Glu Leu Arg Arg Arg Phe Glu Asp Leu Leu Ala Arg Leu 
    50                  55                  60                  


Arg Ala Asn Arg Ser Ala Asp Ala Leu Pro Ala Glu Arg Ser Pro Ala 
65                  70                  75                  80  


Pro Val Val His Thr Leu Thr Pro Asp Val Arg Arg Gly His Asp Gly 
                85                  90                  95      


Ser Leu His Leu Arg Ile Pro Arg Ala Ser Leu Pro Pro Gly Val Pro 
            100                 105                 110         


Arg Ala Ser Arg Val Gln His Ala Leu Leu Arg Leu Ser Pro Glu Thr 
        115                 120                 125             


Arg Glu Pro Trp Asp Val Thr Arg Pro Leu Gln Arg Gln Leu Arg Leu 
    130                 135                 140                 


Leu Asp Pro Arg Ala Pro Ala Leu Leu Leu His Leu Trp Pro Pro Ser 
145                 150                 155                 160 


Asp Arg Trp Arg Glu Leu Ser Ser Ala Pro Pro Arg Leu Glu Leu His 
                165                 170                 175     


Leu Arg Thr Arg Ser Ala Arg Gly Arg Arg Ser Thr Arg Met Arg Thr 
            180                 185                 190         


Arg Asp Asp Cys Pro Leu Gly Pro Gly Arg Cys Cys Arg Leu His Thr 
        195                 200                 205             


Val Arg Ala Ser Leu Gln Asp Leu Gly Trp Thr Asp Trp Val Leu Ser 
    210                 215                 220                 


Pro Arg Glu Leu His Val Gly Ile Cys Met Gly Glu Cys Pro Ser Leu 
225                 230                 235                 240 


Tyr Arg Ser Ala Asn Thr His Ala Gln Val Lys Ala Arg Leu His Gly 
                245                 250                 255     


Leu Lys Pro Asp Ser Val Pro Ala Pro Cys Cys Val Pro Ser Ser Tyr 
            260                 265                 270         


Asp Leu Val Val Leu Met His Lys Thr Asp Gly Gly Ile Ala Leu His 
        275                 280                 285             


Thr Tyr Asp Asp Leu Ile Ala Lys Gly Cys His Cys Ala 
    290                 295                 300     


<210>  1852
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Domain (1C1)

<400>  1852

Asp Val Val Leu Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Pro Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Ser Gly Ile Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Leu Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser 
                85                  90                  95      


Thr His Val Pro Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  1853
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Domain (3P10)

<400>  1853

Asp Ile Val Leu Thr Gln Ser Pro Val Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Asn Tyr 
            20                  25                  30          


Gly Ile Ser Phe Met Ser Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Ala Ala Ser His Gln Gly Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu Asn Ile His 
65                  70                  75                  80  


Pro Met Glu Glu Asp Asp Ser Ala Met Tyr Phe Cys Leu Gln Ser Lys 
                85                  90                  95      


Glu Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  1854
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Domain (12A3)

<400>  1854

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Ser Leu Thr Cys Arg Ala Ser Gln Asp Ile Gly Ser Ser 
            20                  25                  30          


Leu Asn Trp Leu Gln Gln Glu Pro Asp Gly Thr Ile Lys Arg Leu Ile 
        35                  40                  45              


Tyr Ala Thr Ser Ser Leu Asp Ser Gly Val Pro Lys Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Ser Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Ser 
65                  70                  75                  80  


Glu Asp Phe Val Asp Tyr Tyr Cys Leu Gln Tyr Ala Ser Ser Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  1855
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Domain (1B3)

<400>  1855

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Gly Lys Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          


Ile Ser Trp Tyr Gln His Lys Pro Gly Lys Ser Pro Arg Leu Leu Ile 
        35                  40                  45              


His Tyr Thr Ser Thr Leu Gln Pro Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Arg Asp Tyr Ser Phe Ser Ile Ser Asn Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Asn Leu Tyr Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  1856
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Domain (2B3)

<400>  1856

Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Leu Gly 
1               5                   10                  15      


Glu Glu Ile Thr Leu Thr Cys Ser Ala Ser Ser Ser Val Phe Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              


Ser Thr Ser Asn Leu Ala Ser Gly Ile Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Phe Tyr Ser Leu Thr Ile Ser Ser Val Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Asp Tyr Tyr Cys His Gln Trp Ser Ser Thr Phe Gly Gly 
                85                  90                  95      


Gly Thr Lys Leu Glu Ile Lys 
            100             


<210>  1857
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Domain (2B11)

<400>  1857

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Asn Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Thr Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Phe 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  1858
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Domain (2B8)

<400>  1858

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Glu Thr Val Thr Ile Thr Cys Arg Pro Ser Glu Asn Ile Tyr Ser Tyr 
            20                  25                  30          


Leu Thr Trp Phe Gln Gln Glu Gln Gly Lys Ser Pro Gln Leu Leu Val 
        35                  40                  45              


Tyr Asn Ala Gln Thr Leu Ala Glu Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr His Phe Ser Leu Lys Ile Asn Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Gly Thr Tyr Tyr Cys Gln His Tyr Tyr Gly Tyr Pro Phe 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  1859
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Domain (22N5)

<400>  1859

Asp Ile Lys Met Thr Gln Ser Pro Ser Ser Met Tyr Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Lys Ser Tyr 
            20                  25                  30          


Leu Asn Trp Phe Gln Gln Lys Pro Gly Lys Ser Pro Lys Thr Leu Ile 
        35                  40                  45              


Tyr Arg Thr Lys Arg Leu Val Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Val Ser Ser Leu Glu Tyr 
65                  70                  75                  80  


Asp Asp Val Gly Ile Tyr Tyr Cys Leu Gln Tyr Val Glu Phe Pro Leu 
                85                  90                  95      


Thr Phe Gly Asp Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  1860
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Domain (P1B6)

<400>  1860

Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Arg Leu Leu Ile Tyr 
        35                  40                  45              


Asp Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Phe Tyr Ser Ile Thr Ile Ser Arg Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Asn Ser Tyr Pro Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  1861
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Domain (P8G4)

<400>  1861

Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Arg Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Asn Asn Asn Pro Pro Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Thr Leu Glu Leu Lys 
            100                 105     


<210>  1862
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Domain (8D8)

<400>  1862

Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser Thr Ser Ile Gly 
1               5                   10                  15      


Asp Arg Val Ser Val Thr Cys Lys Ala Ser Gln Asn Val Gly Thr Asn 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Ala Leu Val 
        35                  40                  45              


Tyr Ser Thr Ser Tyr Arg Tyr Ser Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Glu Tyr Phe Cys His Gln Tyr Asn Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  1863
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Domain (2A9)

<400>  1863

Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asn Val Gly Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Ile Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Asn Arg Phe Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Met Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr Ser Ser Tyr Phe Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys 
            100                 105     


<210>  1864
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Domain (8C10)

<400>  1864

Asp Phe Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Asp Ser Val Ser Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Asn Asn 
            20                  25                  30          


Leu His Trp Tyr Gln Gln Lys Ser His Glu Ser Pro Arg Leu Leu Ile 
        35                  40                  45              


Lys Tyr Ala Ser Gln Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Asn Ser Val Glu Thr 
65                  70                  75                  80  


Glu Asp Phe Gly Val Tyr Phe Cys Gln Gln Ser Asn Ser Trp Pro His 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  1865
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Domain (24G2)

<400>  1865

Asp Ile Leu Leu Thr Gln Ser Pro Ala Ile Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Val Ser Phe Ser Cys Arg Ala Ser Gln Ser Ile Gly Thr Ser 
            20                  25                  30          


Ile His Trp Tyr Gln Gln Arg Thr Asn Gly Ser Pro Arg Leu Leu Ile 
        35                  40                  45              


Lys Tyr Ala Ser Glu Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Ile Ile Asn Ser Val Glu Ser 
65                  70                  75                  80  


Glu Asp Ile Ala Asp Tyr Tyr Cys Gln Gln Ser Asn Ser Trp Pro Thr 
                85                  90                  95      


Phe Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105             


<210>  1866
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Domain (2J23)

<400>  1866

Asp Val Val Met Thr Gln Thr Pro Leu Thr Leu Ser Val Thr Ile Gly 
1               5                   10                  15      


Gln Ser Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu Asp Ser 
            20                  25                  30          


Asp Gly Lys Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Arg Leu Ile Tyr Leu Val Ser Lys Val Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Trp Gln Gly 
                85                  90                  95      


Thr His Phe Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110         


<210>  1867
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Domain (6N16)

<400>  1867

Asp Val Val Met Thr Gln Ala Pro Leu Ile Leu Ser Val Thr Ile Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Asp Gly 
            20                  25                  30          


Asp Gly Glu Thr Tyr Leu Ser Trp Leu Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Arg Leu Ile Tyr Leu Val Ser Lys Leu Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Cys Gln Ser 
                85                  90                  95      


Thr His Phe Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110         


<210>  1868
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Domain (5A20)

<400>  1868

Asp Val Val Met Thr Gln Thr Pro Leu Thr Leu Ser Val Thr Ile Gly 
1               5                   10                  15      


His Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Asp Phe 
            20                  25                  30          


Asp Gly Lys Thr Tyr Leu Asn Trp Leu Phe Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Arg Leu Phe Tyr Leu Val Ser Lys Leu Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Trp Gln Gly 
                85                  90                  95      


Thr His Phe Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  1869
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Domain (17J16)

<400>  1869

Asp Val Ala Leu Thr Gln Ile Pro Leu Thr Leu Ser Val Thr Val Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Ser Asp Ser 
            20                  25                  30          


Asp Gly Lys Thr Tyr Leu Asn Trp Leu Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Arg Leu Ile Tyr Leu Val Ser Arg Leu Gly Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Thr Gly Ser Gly Ser Gly Ala Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Trp Gln Gly 
                85                  90                  95      


Thr His Phe Pro Gln Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  1870
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Domain (1A3)

<400>  1870

Asp Ile Val Met Thr Gln Ala Ala Phe Ser Asn Pro Val Thr Leu Gly 
1               5                   10                  15      


Thr Ser Ala Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Ile Thr Tyr Leu Tyr Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Gln Met Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Ser Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ala Gln His 
                85                  90                  95      


Leu Glu Leu Thr Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  1871
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Domain (P1H8)

<400>  1871

Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Thr Ile Val His Ser 
            20                  25                  30          


Asn Gly Tyr Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  1872
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Domain (25M22)

<400>  1872

Asp Val Val Leu Thr Gln Thr Pro Leu Ser Leu Pro Val Asn Ile Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Lys Ser Thr Lys Ser Leu Leu Asn Ser 
            20                  25                  30          


Asp Glu Phe Thr Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Phe Leu Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Ser 
                85                  90                  95      


Asn Tyr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  1873
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Domain (19K19)

<400>  1873

Asp Val Val Leu Thr Gln Thr Pro Leu Ser Leu Pro Val Asn Ile Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Lys Ser Thr Lys Ser Leu Leu Asn Ser 
            20                  25                  30          


Asp Glu Phe Thr Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Leu Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Ser 
                85                  90                  95      


Asn Tyr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  1874
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Domain (5F12)

<400>  1874

Asn Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Thr Tyr 
            20                  25                  30          


Gly Asn Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asp 
65                  70                  75                  80  


Pro Val Glu Ala Asp Asp Ala Ala Thr Tyr Tyr Cys His Gln Asn Asn 
                85                  90                  95      


Glu Asp Pro Pro Ala Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  1875
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Domain (6G9)

<400>  1875

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Phe Ser 
            20                  25                  30          


Gly Asn Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Asp Ser Gly Ile Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Val Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asn 
65                  70                  75                  80  


Pro Val Glu Ala Asp Asp Val Ala Thr Tyr Tyr Cys Gln Gln Ser Asn 
                85                  90                  95      


Glu Asp Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Glu 
            100                 105                 110     


<210>  1876
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Domain (1A3)

<400>  1876

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Phe Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Met Asn Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Ile Ile Pro Asn Asn Gly Val Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Trp Leu Leu Arg Gly Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Ser Val Thr Val Ser Ser 
        115             


<210>  1877
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Domain (P1B6)

<400>  1877

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Met Asn Trp Val Lys Gln Thr His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Ile Asn Pro Asn Asn Gly Gly Pro Ile Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Asp Ser Ala Trp Phe Thr Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ala 
        115         


<210>  1878
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Domain (P1H8)

<400>  1878

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Met Asn Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Ile Asn Pro Asn Asn Gly Gly Thr Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gln Gly Pro Trp Tyr Phe Asp Val Trp Gly Thr Gly Thr Thr 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  1879
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Domain (P8G4)

<400>  1879

Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Tyr 
            20                  25                  30          


Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Asp Trp Leu 
        35                  40                  45              


Gly Val Leu Trp Ser Gly Gly Ser Thr Asp Tyr Asn Ala Ala Phe Ile 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Phe Phe 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Ala Asp Asp Thr Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asn Phe Gly Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  1880
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Domain (1A3)

<400>  1880

Asp Ile Val Met Thr Gln Ala Ala Phe Ser Asn Pro Val Thr Leu Gly 
1               5                   10                  15      


Thr Ser Ala Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Ile Thr Tyr Leu Tyr Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Gln Met Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Ser Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ala Gln His 
                85                  90                  95      


Leu Glu Leu Thr Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  1881
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Domain (P1B6)

<400>  1881

Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Arg Leu Leu Ile Tyr 
        35                  40                  45              


Asp Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Phe Tyr Ser Ile Thr Ile Ser Arg Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Asn Ser Tyr Pro Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  1882
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Domain (P1H8)

<400>  1882

Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Thr Ile Val His Ser 
            20                  25                  30          


Asn Gly Tyr Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  1883
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Domain (P8G4)

<400>  1883

Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Arg Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Asn Asn Asn Pro Pro Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Thr Leu Glu Leu Lys 
            100                 105     


<210>  1884
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Domain (1C1)

<400>  1884

Gln Met Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Asn Asp Tyr 
            20                  25                  30          


Gly Val His Trp Ile Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Ser Gly Gly Arg Thr Asp Tyr Asn Ala Ala Phe Ile 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Phe Phe 
65                  70                  75                  80  


Lys Met Ser Ser Leu Gln Pro Asn Asp Thr Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Trp Ala Leu Tyr Phe Leu Tyr Gly Gly Ser Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120     


<210>  1885
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Domain (2A9)

<400>  1885

Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Thr Ser Gly Gly Thr Thr Tyr Tyr Thr Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Asn Ile Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Gly Asn Phe Tyr Tyr Tyr Gly Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Ser Val Thr Val Ser Ser 
        115                 


<210>  1886
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Domain (2J23)

<400>  1886

Gln Ala Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Asn Ile Asp Trp Val Arg Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Phe Pro Gly Asp Gly Ser Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Gln Ala Thr Leu Thr Thr Asp Lys Ser Ser Ser Thr Thr Tyr 
65                  70                  75                  80  


Ile His Leu Ser Arg Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ser Gly Ile Tyr Tyr Gly Ser His Phe Val Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ala 
        115                 120 


<210>  1887
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Domain (5A20)

<400>  1887

Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Met Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Ile Leu Ser Cys Lys Ala Ile Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Trp Ile Glu Trp Val Lys Glu Arg Pro Gly His Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Leu Leu Gly Ser Asp Ser Ile His Phe Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Ile Ser Ala Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Thr Glu Asp Ser Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Val Arg Gln Asp Trp Asn Trp Tyr Phe Asp Val Trp Gly Thr Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  1888
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Domain (8C10)

<400>  1888

Gln Val Gln Leu Gln Gln Ser Gly Val Glu Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ala Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ala Asn Tyr 
            20                  25                  30          


Gly Leu Thr Trp Val Lys Gln Arg Thr Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Tyr Pro Gly Ser Gly His Thr His Tyr Asn Glu Asp Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Arg Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Arg Ile Gln Leu Leu Leu Pro Val Gly Gly Phe Val Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ala 
        115                 120         


<210>  1889
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Domain (8D8)

<400>  1889

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Arg Tyr 
            20                  25                  30          


Ser Val His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Met Ile Trp Gly Phe Gly Ser Thr Asp Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Thr Lys Asp Asn Ser Lys Ser Gln Phe Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ile His Thr Thr Ala Gly Ser Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ala 
        115     


<210>  1890
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Domain (12A3)

<400>  1890

Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Pro Phe Thr Ile Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Glu Gln Ala Pro Gly Lys Gly Leu Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Ser Gly Val Pro Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Asn Asn Leu Lys Asp Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Ser Ala Thr Gly Asn Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  1891
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Domain (17J16)

<400>  1891

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Trp Ile His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Asn Ser Asn Tyr Ala Glu Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Val Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Leu Ser Arg Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Asp Trp Asn Trp Tyr Phe His Val Trp Gly Ala Gly Ser 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  1892
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Domain (25M22)

<400>  1892

Gln Val Gln Leu Gln Gln Ser Gly Pro Asp Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Val Asn Trp Met Lys Gln Arg Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Tyr Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ala Tyr Leu Leu Arg Leu Arg Arg Thr Gly Tyr Tyr Ala Met 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120                 125 


<210>  1893
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Domain (19K19)

<400>  1893

Gln Val Gln Leu Gln Gln Ser Gly Pro Asp Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Lys Gln Arg Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Tyr Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ala Tyr Leu Leu Arg Leu Arg Arg Thr Gly Tyr Tyr Ala Met 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120                 125 


<210>  1894
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Domain (22N5)

<400>  1894

Gln Asn Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ile Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ser Met His Trp Val Lys Lys Thr Pro Gly Lys Gly Phe Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Glu Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Asn Thr Ala His 
65                  70                  75                  80  


Leu Gln Ile Thr Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Val Lys Gly Thr Leu Asn Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  1895
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Domain (1C1)

<400>  1895

Asp Val Val Leu Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Pro Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Ser Gly Ile Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Leu Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser 
                85                  90                  95      


Thr His Val Pro Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  1896
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Domain (2A9)

<400>  1896

Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asn Val Gly Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Ile Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Asn Arg Phe Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Met Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr Ser Ser Tyr Phe Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys 
            100                 105     


<210>  1897
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Domain (2J23)

<400>  1897

Asp Val Val Met Thr Gln Thr Pro Leu Thr Leu Ser Val Thr Ile Gly 
1               5                   10                  15      


Gln Ser Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu Asp Ser 
            20                  25                  30          


Asp Gly Lys Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Arg Leu Ile Tyr Leu Val Ser Lys Val Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Trp Gln Gly 
                85                  90                  95      


Thr His Phe Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110         


<210>  1898
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Domain (5A20)

<400>  1898

Asp Val Val Met Thr Gln Thr Pro Leu Thr Leu Ser Val Thr Ile Gly 
1               5                   10                  15      


His Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Asp Phe 
            20                  25                  30          


Asp Gly Lys Thr Tyr Leu Asn Trp Leu Phe Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Arg Leu Phe Tyr Leu Val Ser Lys Leu Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Trp Gln Gly 
                85                  90                  95      


Thr His Phe Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  1899
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Domain (8C10)

<400>  1899

Asp Phe Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Asp Ser Val Ser Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Asn Asn 
            20                  25                  30          


Leu His Trp Tyr Gln Gln Lys Ser His Glu Ser Pro Arg Leu Leu Ile 
        35                  40                  45              


Lys Tyr Ala Ser Gln Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Asn Ser Val Glu Thr 
65                  70                  75                  80  


Glu Asp Phe Gly Val Tyr Phe Cys Gln Gln Ser Asn Ser Trp Pro His 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  1900
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Domain (8D8)

<400>  1900

Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser Thr Ser Ile Gly 
1               5                   10                  15      


Asp Arg Val Ser Val Thr Cys Lys Ala Ser Gln Asn Val Gly Thr Asn 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Ala Leu Val 
        35                  40                  45              


Tyr Ser Thr Ser Tyr Arg Tyr Ser Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Glu Tyr Phe Cys His Gln Tyr Asn Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  1901
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Domain (12A3)

<400>  1901

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Ser Leu Thr Cys Arg Ala Ser Gln Asp Ile Gly Ser Ser 
            20                  25                  30          


Leu Asn Trp Leu Gln Gln Glu Pro Asp Gly Thr Ile Lys Arg Leu Ile 
        35                  40                  45              


Tyr Ala Thr Ser Ser Leu Asp Ser Gly Val Pro Lys Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Ser Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Ser 
65                  70                  75                  80  


Glu Asp Phe Val Asp Tyr Tyr Cys Leu Gln Tyr Ala Ser Ser Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  1902
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Domain (17J16)

<400>  1902

Asp Val Ala Leu Thr Gln Ile Pro Leu Thr Leu Ser Val Thr Val Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Ser Asp Ser 
            20                  25                  30          


Asp Gly Lys Thr Tyr Leu Asn Trp Leu Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Arg Leu Ile Tyr Leu Val Ser Arg Leu Gly Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Thr Gly Ser Gly Ser Gly Ala Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Trp Gln Gly 
                85                  90                  95      


Thr His Phe Pro Gln Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  1903
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Domain (25M22)

<400>  1903

Asp Val Val Leu Thr Gln Thr Pro Leu Ser Leu Pro Val Asn Ile Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Lys Ser Thr Lys Ser Leu Leu Asn Ser 
            20                  25                  30          


Asp Glu Phe Thr Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Phe Leu Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Ser 
                85                  90                  95      


Asn Tyr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  1904
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Domain (19K19)

<400>  1904

Asp Val Val Leu Thr Gln Thr Pro Leu Ser Leu Pro Val Asn Ile Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Lys Ser Thr Lys Ser Leu Leu Asn Ser 
            20                  25                  30          


Asp Glu Phe Thr Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Leu Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Ser 
                85                  90                  95      


Asn Tyr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  1905
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Domain (22N5)

<400>  1905

Asp Ile Lys Met Thr Gln Ser Pro Ser Ser Met Tyr Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Lys Ser Tyr 
            20                  25                  30          


Leu Asn Trp Phe Gln Gln Lys Pro Gly Lys Ser Pro Lys Thr Leu Ile 
        35                  40                  45              


Tyr Arg Thr Lys Arg Leu Val Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Val Ser Ser Leu Glu Tyr 
65                  70                  75                  80  


Asp Asp Val Gly Ile Tyr Tyr Cys Leu Gln Tyr Val Glu Phe Pro Leu 
                85                  90                  95      


Thr Phe Gly Asp Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  1906
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Domain (1B3)

<400>  1906

Gln Val His Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Phe Thr Phe Thr Gly Tyr 
            20                  25                  30          


Asn Ile Asn Trp Val Arg Leu Arg Pro Glu Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Phe Pro Gly Asp Asp Asn Ala Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Thr Asp Lys Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Arg Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Thr Pro Val Leu Ser Asn Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser Ser 
        115                 


<210>  1907
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Domain (2B11)

<400>  1907

Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Leu Thr Cys Ser Val Thr Gly Tyr Ser Ile Thr Ser Gly 
            20                  25                  30          


Tyr Tyr Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp 
        35                  40                  45              


Met Gly His Ile Ala Asn Asp Gly Ser Asn Tyr Tyr Asn Pro Phe Leu 
    50                  55                  60                  


Lys His Arg Val Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe 
65                  70                  75                  80  


Leu Lys Leu Asn Ser Val Thr Ile Gln Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Ser Tyr Phe Asp Tyr Val Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser Ser 
        115                 


<210>  1908
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Domain (3P10)

<400>  1908

Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Gly Val Ile Trp Val Lys Gln Ala Pro Gly Lys Ala Leu Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Asp Leu 
    50                  55                  60                  


Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Ser Ala Ser 
65                  70                  75                  80  


Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Arg Tyr Gly Pro Glu Asp Ile Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Leu Thr Val Ser Ser 
        115             


<210>  1909
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Domain (5F12)

<400>  1909

Gln Val Gln Leu Lys Gln Ser Gly Thr Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Ile Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Ala Arg Ile Tyr Pro Gly Asn Gly Asn Thr Tyr His Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Glu Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Glu Gly Leu Tyr Tyr Asp Tyr Asp Arg Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Ala Leu Thr Val Ser Ser 
        115                 120         


<210>  1910
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Domain (6G9)

<400>  1910

Gln Val Gln Leu His Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met Gln Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asp Pro Ser Asp Ser Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Thr Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Pro Leu Asp Arg Ser Ala Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120 


<210>  1911
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Domain (6N16)

<400>  1911

Gln Val Gln Leu Gln Gln Ser Gly Ser Glu Leu Val Lys Pro Gly Thr 
1               5                   10                  15      


Ser Met Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Ile Asn Trp Val Arg Leu Arg Pro Glu Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Phe Pro Gly Asp Asp Ser Ile Lys Tyr Asn Glu Asn Phe 
    50                  55                  60                  


Arg Gly Lys Ala Thr Leu Thr Thr Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met His Leu Ser Arg Leu Thr Ser Asp Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ser Gly Ile Phe Tyr Gly Asn Asn Phe Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ala 
        115                 120 


<210>  1912
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Domain (1B3)

<400>  1912

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Gly Lys Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          


Ile Ser Trp Tyr Gln His Lys Pro Gly Lys Ser Pro Arg Leu Leu Ile 
        35                  40                  45              


His Tyr Thr Ser Thr Leu Gln Pro Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Arg Asp Tyr Ser Phe Ser Ile Ser Asn Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Asn Leu Tyr Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  1913
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Domain (2B11)

<400>  1913

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Asn Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Thr Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Phe 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  1914
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Domain (3P10)

<400>  1914

Asp Ile Val Leu Thr Gln Ser Pro Val Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Asn Tyr 
            20                  25                  30          


Gly Ile Ser Phe Met Ser Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Ala Ala Ser His Gln Gly Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu Asn Ile His 
65                  70                  75                  80  


Pro Met Glu Glu Asp Asp Ser Ala Met Tyr Phe Cys Leu Gln Ser Lys 
                85                  90                  95      


Glu Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  1915
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Domain (5F12)

<400>  1915

Asn Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Thr Tyr 
            20                  25                  30          


Gly Asn Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asp 
65                  70                  75                  80  


Pro Val Glu Ala Asp Asp Ala Ala Thr Tyr Tyr Cys His Gln Asn Asn 
                85                  90                  95      


Glu Asp Pro Pro Ala Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  1916
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Domain (6G9)

<400>  1916

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Phe Ser 
            20                  25                  30          


Gly Asn Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Asp Ser Gly Ile Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Val Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asn 
65                  70                  75                  80  


Pro Val Glu Ala Asp Asp Val Ala Thr Tyr Tyr Cys Gln Gln Ser Asn 
                85                  90                  95      


Glu Asp Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Glu 
            100                 105                 110     


<210>  1917
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Domain (6N16)

<400>  1917

Asp Val Val Met Thr Gln Ala Pro Leu Ile Leu Ser Val Thr Ile Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Asp Gly 
            20                  25                  30          


Asp Gly Glu Thr Tyr Leu Ser Trp Leu Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Arg Leu Ile Tyr Leu Val Ser Lys Leu Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Cys Gln Ser 
                85                  90                  95      


Thr His Phe Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110         


<210>  1918
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Domain (1C1)

<400>  1918

Gln Met Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Asn Asp Tyr 
            20                  25                  30          


Gly Val His Trp Ile Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Ser Gly Gly Arg Thr Asp Tyr Asn Ala Ala Phe Ile 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Phe Phe 
65                  70                  75                  80  


Lys Met Ser Ser Leu Gln Pro Asn Asp Thr Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Trp Ala Leu Tyr Phe Leu Tyr Gly Gly Ser Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120     


<210>  1919
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Domain (HC-349a)

<400>  1919

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Asn Asp Tyr 
            20                  25                  30          


Gly Val His Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Trp Ser Gly Gly Arg Thr Asp Tyr Asn Ala Ala Phe Ile 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Trp Ala Leu Tyr Phe Leu Tyr Gly Gly Ser Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  1920
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Domain (HC-349b)

<400>  1920

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Asn Asp Tyr 
            20                  25                  30          


Gly Val His Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Trp Ser Gly Gly Arg Thr Asp Tyr Asn Ala Ala Phe Ile 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Trp Ala Leu Tyr Phe Leu Tyr Gly Gly Ser Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  1921
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Domain (HC-349c)

<400>  1921

Gln Met Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Asn Asp Tyr 
            20                  25                  30          


Gly Val His Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Trp Ser Gly Gly Arg Thr Asp Tyr Asn Ala Ala Phe Ile 
    50                  55                  60                  


Ser Arg Leu Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Trp Ala Leu Tyr Phe Leu Tyr Gly Gly Ser Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  1922
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Domain (HC-349d)

<400>  1922

Gln Met Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Asn Asp Tyr 
            20                  25                  30          


Gly Val His Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Trp Ser Gly Gly Arg Thr Asp Tyr Asn Ala Ala Phe Ile 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Ser Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Trp Ala Leu Tyr Phe Leu Tyr Gly Gly Ser Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  1923
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Domain (HC-349e)

<400>  1923

Gln Met Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Asn Asp Tyr 
            20                  25                  30          


Gly Val His Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Trp Ser Gly Gly Arg Thr Asp Tyr Asn Ala Ala Phe Ile 
    50                  55                  60                  


Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Met Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Trp Ala Leu Tyr Phe Leu Tyr Gly Gly Ser Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  1924
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Domain (HC-349f)

<400>  1924

Gln Met Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Asn Asp Tyr 
            20                  25                  30          


Gly Val His Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Ser Gly Gly Arg Thr Asp Tyr Asn Ala Ala Phe Ile 
    50                  55                  60                  


Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Ser Phe 
65                  70                  75                  80  


Lys Met Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Trp Ala Leu Tyr Phe Leu Tyr Gly Gly Ser Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  1925
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Domain (HC-350a)

<400>  1925

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Asn Asp Tyr 
            20                  25                  30          


Gly Val His Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Trp Ser Gly Gly Arg Thr Asp Tyr Asn Ala Ala Phe Ile 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Trp Ala Leu Tyr Phe Leu Tyr Gly Gly Ser Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  1926
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Domain (HC-350b)

<400>  1926

Gln Met Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Asn Asp Tyr 
            20                  25                  30          


Gly Val His Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Trp Ser Gly Gly Arg Thr Asp Tyr Asn Ala Ala Phe Ile 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Ser Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Trp Ala Leu Tyr Phe Leu Tyr Gly Gly Ser Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  1927
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Domain (HC-350c)

<400>  1927

Gln Met Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Asn Asp Tyr 
            20                  25                  30          


Gly Val His Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Trp Ser Gly Gly Arg Thr Asp Tyr Asn Ala Ala Phe Ile 
    50                  55                  60                  


Ser Arg Leu Thr Ile Ser Arg Asp Thr Ser Lys Ser Gln Val Ser Phe 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Trp Ala Leu Tyr Phe Leu Tyr Gly Gly Ser Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  1928
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Domain

<400>  1928

Asp Val Val Leu Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Pro Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Ser Gly Ile Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Leu Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser 
                85                  90                  95      


Thr His Val Pro Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  1929
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Domain (LC-349a)

<400>  1929

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Ser Gly Ile Thr Tyr Leu His Trp Phe Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Arg Leu Ile Tyr Lys Leu Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ser Gln Ser 
                85                  90                  95      


Thr His Val Pro Pro Trp Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys 
    


<210>  1930
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Domain (LC-349b)

<400>  1930

Asp Val Val Leu Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Ser Gly Ile Thr Tyr Leu His Trp Tyr Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Arg Leu Ile Tyr Lys Leu Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ser Gln Ser 
                85                  90                  95      


Thr His Val Pro Pro Trp Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys 
    


<210>  1931
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Domain (LC-349c)

<400>  1931

Asp Val Val Leu Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Ser Gly Ile Thr Tyr Leu His Trp Tyr Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Leu Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ser Gln Ser 
                85                  90                  95      


Thr His Val Pro Pro Trp Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys 
    


<210>  1932
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Domain (LC-349d)

<400>  1932

Asp Val Val Leu Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Asp Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Ser Gly Ile Thr Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Leu Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ser Gln Ser 
                85                  90                  95      


Thr His Val Pro Pro Trp Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys 
    


<210>  1933
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Domain (LC-350a)

<400>  1933

Asp Val Val Leu Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Pro Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Ser Gly Ile Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Leu Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser 
                85                  90                  95      


Thr His Val Pro Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  1934
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Domain (LC-350b)

<400>  1934

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Pro Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Ser Gly Ile Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Leu Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser 
                85                  90                  95      


Thr His Val Pro Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  1935
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Domain (25M22)

<400>  1935

Gln Val Gln Leu Gln Gln Ser Gly Pro Asp Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Val Asn Trp Met Lys Gln Arg Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Tyr Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ala Tyr Leu Leu Arg Leu Arg Arg Thr Gly Tyr Tyr Ala Met 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120                 125 


<210>  1936
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Domain (HC-389a)

<400>  1936

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Val Asn Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Tyr Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe 
    50                  55                  60                  


Lys Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Tyr Leu Leu Arg Leu Arg Arg Thr Gly Tyr Tyr Ala Met 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125 


<210>  1937
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Domain (HC-389b)

<400>  1937

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Val Asn Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Tyr Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe 
    50                  55                  60                  


Lys Gly Gln Ala Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Tyr Leu Leu Arg Leu Arg Arg Thr Gly Tyr Tyr Ala Met 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125 


<210>  1938
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Domain (HC-389c)

<400>  1938

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Val Asn Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Tyr Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe 
    50                  55                  60                  


Lys Gly Gln Ala Thr Leu Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Tyr Leu Leu Arg Leu Arg Arg Thr Gly Tyr Tyr Ala Met 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125 


<210>  1939
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Domain (HC-390a)

<400>  1939

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Val Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Tyr Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Tyr Leu Leu Arg Leu Arg Arg Thr Gly Tyr Tyr Ala Met 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125 


<210>  1940
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Domain (HC-390b)

<400>  1940

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Val Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Tyr Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe 
    50                  55                  60                  


Lys Gly Arg Ala Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Tyr Leu Leu Arg Leu Arg Arg Thr Gly Tyr Tyr Ala Met 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125 


<210>  1941
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Domain (HC-390c)

<400>  1941

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Val Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Tyr Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe 
    50                  55                  60                  


Lys Gly Arg Ala Thr Leu Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Tyr Leu Leu Arg Leu Arg Arg Thr Gly Tyr Tyr Ala Met 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125 


<210>  1942
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Domain (25M22)

<400>  1942

Asp Val Val Leu Thr Gln Thr Pro Leu Ser Leu Pro Val Asn Ile Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Lys Ser Thr Lys Ser Leu Leu Asn Ser 
            20                  25                  30          


Asp Glu Phe Thr Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Phe Leu Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Ser 
                85                  90                  95      


Asn Tyr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  1943
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Domain (LC-389a)

<400>  1943

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Thr Lys Ser Leu Leu Asn Ser 
            20                  25                  30          


Asp Glu Phe Thr Tyr Leu Asp Trp Phe Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Arg Leu Ile Tyr Leu Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln Ser 
                85                  90                  95      


Asn Tyr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  1944
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Domain (LC-389b)

<400>  1944

Asp Val Val Leu Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Thr Lys Ser Leu Leu Asn Ser 
            20                  25                  30          


Asp Glu Phe Thr Tyr Leu Asp Trp Phe Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Leu Leu Ile Tyr Leu Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln Ser 
                85                  90                  95      


Asn Tyr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  1945
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Domain (LC-389c)

<400>  1945

Asp Val Val Leu Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Thr Lys Ser Leu Leu Asn Ser 
            20                  25                  30          


Asp Glu Phe Thr Tyr Leu Asp Trp Tyr Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Leu Leu Ile Phe Leu Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln Ser 
                85                  90                  95      


Asn Tyr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  1946
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Domain (LC-390a)

<400>  1946

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Lys Ser Thr Lys Ser Leu Leu Asn Ser 
            20                  25                  30          


Asp Glu Phe Thr Tyr Leu Asp Trp Tyr Gln Gln Lys Pro Gly Gln Ala 
        35                  40                  45              


Pro Arg Leu Leu Ile Tyr Leu Val Ser Asn Arg Phe Ser Gly Ile Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
65                  70                  75                  80  


Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Phe Gln Ser 
                85                  90                  95      


Asn Tyr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  1947
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Domain (LC-390b)

<400>  1947

Glu Val Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Lys Ser Thr Lys Ser Leu Leu Asn Ser 
            20                  25                  30          


Asp Glu Phe Thr Tyr Leu Asp Trp Tyr Gln Gln Lys Pro Gly Gln Ala 
        35                  40                  45              


Pro Arg Leu Leu Ile Phe Leu Val Ser Asn Arg Phe Ser Gly Ile Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
65                  70                  75                  80  


Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Phe Gln Ser 
                85                  90                  95      


Asn Tyr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  1948
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Domain (17J16)

<400>  1948

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Trp Ile His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Asn Ser Asn Tyr Ala Glu Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Val Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Leu Ser Arg Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Asp Trp Asn Trp Tyr Phe His Val Trp Gly Ala Gly Ser 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  1949
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Domain (HC-356a)

<400>  1949

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Trp Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Ile Asn Pro Asn Ser Asn Tyr Ala Glu Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Val Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Asp Trp Asn Trp Tyr Phe His Val Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  1950
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Domain (HC-356b)

<400>  1950

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Trp Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Asn Ser Asn Tyr Ala Glu Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Val Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Asp Trp Asn Trp Tyr Phe His Val Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  1951
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Domain (HC-356c)

<400>  1951

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Trp Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Asn Ser Asn Tyr Ala Glu Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Val Arg Ala Thr Leu Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Glu Leu Ser Arg Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Asp Trp Asn Trp Tyr Phe His Val Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  1952
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Domain (HC-356d)

<400>  1952

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Trp Ile His Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Asn Ser Asn Tyr Ala Glu Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Val Arg Ala Thr Leu Thr Ala Asp Glu Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Glu Leu Ser Arg Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Asp Trp Asn Trp Tyr Phe His Val Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  1953
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Domain (17J16)

<400>  1953

Asp Val Ala Leu Thr Gln Ile Pro Leu Thr Leu Ser Val Thr Val Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Ser Asp Ser 
            20                  25                  30          


Asp Gly Lys Thr Tyr Leu Asn Trp Leu Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Arg Leu Ile Tyr Leu Val Ser Arg Leu Gly Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Thr Gly Ser Gly Ser Gly Ala Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Trp Gln Gly 
                85                  90                  95      


Thr His Phe Pro Gln Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  1954
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Domain (LC-356a)

<400>  1954

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Ser Asp Ser 
            20                  25                  30          


Asp Gly Lys Thr Tyr Leu Asn Trp Phe Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Arg Leu Ile Tyr Leu Val Ser Arg Leu Gly Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Trp Gln Gly 
                85                  90                  95      


Thr His Phe Pro Gln Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  1955
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Domain (LC-356b)

<400>  1955

Asp Val Val Leu Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Ser Asp Ser 
            20                  25                  30          


Asp Gly Lys Thr Tyr Leu Asn Trp Leu Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Arg Leu Ile Tyr Leu Val Ser Arg Leu Gly Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Trp Gln Gly 
                85                  90                  95      


Thr His Phe Pro Gln Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  1956
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Domain (LC-356c)

<400>  1956

Asp Val Ala Leu Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Ser Asp Ser 
            20                  25                  30          


Asp Gly Lys Thr Tyr Leu Asn Trp Leu Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Arg Leu Ile Tyr Leu Val Ser Arg Leu Gly Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Ala Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Trp Gln Gly 
                85                  90                  95      


Thr His Phe Pro Gln Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  1957
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Domain (5F12)

<400>  1957

Gln Val Gln Leu Lys Gln Ser Gly Thr Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Ile Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Ala Arg Ile Tyr Pro Gly Asn Gly Asn Thr Tyr His Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Glu Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Glu Gly Leu Tyr Tyr Asp Tyr Asp Arg Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Ala Leu Thr Val Ser Ser 
        115                 120         


<210>  1958
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Domain (HC-375a)

<400>  1958

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Tyr Pro Gly Asn Gly Asn Thr Tyr His Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Leu Tyr Tyr Asp Tyr Asp Arg Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  1959
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Domain (HC-375b)

<400>  1959

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Tyr Pro Gly Asn Gly Asn Thr Tyr His Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Leu Tyr Tyr Asp Tyr Asp Arg Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  1960
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Domain (HC-375c)

<400>  1960

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Tyr Pro Gly Asn Gly Asn Thr Tyr His Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Leu Tyr Tyr Asp Tyr Asp Arg Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  1961
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Domain (HC-375d)

<400>  1961

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Tyr Pro Gly Asn Gly Asn Thr Tyr His Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Ala Thr Leu Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Leu Tyr Tyr Asp Tyr Asp Arg Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  1962
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Domain (HC-375e)

<400>  1962

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Tyr Pro Gly Asn Gly Asn Thr Tyr His Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Ala Thr Leu Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Leu Tyr Tyr Asp Tyr Asp Arg Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  1963
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Domain (HC-375f)

<400>  1963

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Val Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Ile Asn Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Tyr Pro Gly Asn Gly Asn Thr Tyr His Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Ala Thr Leu Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Leu Tyr Tyr Asp Tyr Asp Arg Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  1964
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Domain (HC-375g)

<400>  1964

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Ala Arg Ile Tyr Pro Gly Asn Gly Asn Thr Tyr His Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Ala Thr Leu Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Leu Tyr Tyr Asp Tyr Asp Arg Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  1965
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Domain (HC-375h)

<400>  1965

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Ile 
        35                  40                  45              


Ala Arg Ile Tyr Pro Gly Asn Gly Asn Thr Tyr His Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Ala Thr Leu Thr Arg Asp Lys Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Leu Tyr Tyr Asp Tyr Asp Arg Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  1966
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Domain (5F12)

<400>  1966

Asn Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Thr Tyr 
            20                  25                  30          


Gly Asn Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asp 
65                  70                  75                  80  


Pro Val Glu Ala Asp Asp Ala Ala Thr Tyr Tyr Cys His Gln Asn Asn 
                85                  90                  95      


Glu Asp Pro Pro Ala Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  1967
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Domain (LC-375a)

<400>  1967

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Arg Ala Ser Glu Ser Val Asp Thr Tyr 
            20                  25                  30          


Gly Asn Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys His Gln Asn Asn 
                85                  90                  95      


Glu Asp Pro Pro Ala Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110     


<210>  1968
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Domain (LC-375b)

<400>  1968

Asp Ile Val Leu Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Arg Ala Ser Glu Ser Val Asp Thr Tyr 
            20                  25                  30          


Gly Asn Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Val Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys His Gln Asn Asn 
                85                  90                  95      


Glu Asp Pro Pro Ala Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110     


<210>  1969
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Domain (LC-375g)

<400>  1969

Asp Ile Val Leu Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Arg Ala Ser Glu Ser Val Asp Thr Tyr 
            20                  25                  30          


Gly Asn Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys His Gln Asn Asn 
                85                  90                  95      


Glu Asp Pro Pro Ala Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110     


<210>  1970
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Domain (LC-375c)

<400>  1970

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Ser Val Asp Thr Tyr 
            20                  25                  30          


Gly Asn Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ser 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys His Gln Asn Asn 
                85                  90                  95      


Glu Asp Pro Pro Ala Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110     


<210>  1971
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Domain (LC-375d)

<400>  1971

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Ser Val Asp Thr Tyr 
            20                  25                  30          


Gly Asn Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ser 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Val Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys His Gln Asn Asn 
                85                  90                  95      


Glu Asp Pro Pro Ala Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110     


<210>  1972
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Domain (LC-375e)

<400>  1972

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Glu Ser Val Asp Thr Tyr 
            20                  25                  30          


Gly Asn Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
        35                  40                  45              


Arg Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys His Gln Asn Asn 
                85                  90                  95      


Glu Asp Pro Pro Ala Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110     


<210>  1973
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Domain (LC-375f)

<400>  1973

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Glu Ser Val Asp Thr Tyr 
            20                  25                  30          


Gly Asn Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
        35                  40                  45              


Arg Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Val Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys His Gln Asn Asn 
                85                  90                  95      


Glu Asp Pro Pro Ala Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110     


<210>  1974
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Domain (LC-375h)

<400>  1974

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Thr Tyr 
            20                  25                  30          


Gly Asn Ser Phe Met His Trp Phe Gln Gln Arg Pro Gly Gln Ser Pro 
        35                  40                  45              


Arg Arg Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser 
65                  70                  75                  80  


Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys His Gln Asn Asn 
                85                  90                  95      


Glu Asp Pro Pro Ala Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110     


<210>  1975
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Domain (LC-375i)

<400>  1975

Asp Val Val Leu Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Thr Tyr 
            20                  25                  30          


Gly Asn Ser Phe Met His Trp Phe Gln Gln Arg Pro Gly Gln Ser Pro 
        35                  40                  45              


Arg Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser 
65                  70                  75                  80  


Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys His Gln Asn Asn 
                85                  90                  95      


Glu Asp Pro Pro Ala Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110     


<210>  1976
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Domain (LC-375j)

<400>  1976

Asp Ile Val Leu Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Thr Tyr 
            20                  25                  30          


Gly Asn Ser Phe Met His Trp Tyr Gln Gln Arg Pro Gly Gln Ser Pro 
        35                  40                  45              


Arg Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Lys Ile Ser 
65                  70                  75                  80  


Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys His Gln Asn Asn 
                85                  90                  95      


Glu Asp Pro Pro Ala Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110     


<210>  1977
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Domain (3P10)

<400>  1977

Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Gly Val Ile Trp Val Lys Gln Ala Pro Gly Lys Ala Leu Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Asp Leu 
    50                  55                  60                  


Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Ser Ala Ser 
65                  70                  75                  80  


Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Arg Tyr Gly Pro Glu Asp Ile Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Leu Thr Val Ser Ser 
        115             


<210>  1978
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Domain (HC-344a)

<400>  1978

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Gly Val Ile Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Asp Leu 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Tyr Gly Pro Glu Asp Ile Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  1979
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Domain (HC-344b)

<400>  1979

Gln Ile Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Gly Val Ile Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Asp Leu 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Thr Leu Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Tyr Gly Pro Glu Asp Ile Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  1980
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Domain (HC-344c)

<400>  1980

Gln Ile Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Gly Val Ile Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Asp Leu 
    50                  55                  60                  


Lys Gly Arg Phe Thr Phe Thr Leu Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Tyr Gly Pro Glu Asp Ile Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  1981
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Domain (HC-344d)

<400>  1981

Gln Ile Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Gly Val Ile Trp Val Arg Gln Ala Pro Gly Lys Ala Leu Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Asp Leu 
    50                  55                  60                  


Lys Gly Arg Val Thr Phe Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Asn Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Arg Tyr Gly Pro Glu Asp Ile Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  1982
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Domain (HC-344e)

<400>  1982

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Gly Val Ile Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Asp Leu 
    50                  55                  60                  


Lys Gly Arg Val Thr Phe Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Tyr Gly Pro Glu Asp Ile Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  1983
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Domain (HC-344f)

<400>  1983

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Gly Val Ile Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Asp Leu 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Tyr Gly Pro Glu Asp Ile Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  1984
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Domain (HC-344g)

<400>  1984

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Gly Val Ile Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Asp Leu 
    50                  55                  60                  


Lys Gly Arg Val Thr Phe Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Tyr Gly Pro Glu Asp Ile Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  1985
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Domain (HC-344h)

<400>  1985

Gln Ile Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Gly Val Ile Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Asp Leu 
    50                  55                  60                  


Lys Gly Arg Val Thr Phe Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Tyr Gly Pro Glu Asp Ile Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  1986
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Domain (HC-345a)

<400>  1986

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Val Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Gly Val Ile Trp Met Gln Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Asp Leu 
    50                  55                  60                  


Lys Gly Arg Val Thr Leu Thr Ala Asp Thr Ser Thr Asp Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Arg Tyr Gly Pro Glu Asp Ile Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Met Val Thr Val Ser Ser 
        115             


<210>  1987
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Domain (HC-345b)

<400>  1987

Gln Ile Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Val Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Gly Val Ile Trp Met Gln Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Asp Leu 
    50                  55                  60                  


Lys Gly Arg Phe Thr Phe Thr Ala Asp Thr Ser Thr Asp Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Arg Tyr Gly Pro Glu Asp Ile Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Met Val Thr Val Ser Ser 
        115             


<210>  1988
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Domain (HC-345c)

<400>  1988

Gln Ile Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Val Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Gly Val Ile Trp Met Gln Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Asp Leu 
    50                  55                  60                  


Lys Gly Arg Phe Thr Phe Thr Ala Asp Thr Ser Thr Asp Thr Ala Tyr 
65                  70                  75                  80  


Leu Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Arg Tyr Gly Pro Glu Asp Ile Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Met Val Thr Val Ser Ser 
        115             


<210>  1989
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Domain (3P10)

<400>  1989

Asp Ile Val Leu Thr Gln Ser Pro Val Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Asn Tyr 
            20                  25                  30          


Gly Ile Ser Phe Met Ser Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Ala Ala Ser His Gln Gly Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu Asn Ile His 
65                  70                  75                  80  


Pro Met Glu Glu Asp Asp Ser Ala Met Tyr Phe Cys Leu Gln Ser Lys 
                85                  90                  95      


Glu Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  1990
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Domain (LC-344a)

<400>  1990

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Asn Tyr 
            20                  25                  30          


Gly Ile Ser Phe Met Ser Trp Phe Gln Gln Arg Pro Gly Gln Ser Pro 
        35                  40                  45              


Arg Arg Leu Ile Tyr Ala Ala Ser His Gln Gly Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser 
65                  70                  75                  80  


Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Leu Gln Ser Lys 
                85                  90                  95      


Glu Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110     


<210>  1991
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Domain (LC-344b)

<400>  1991

Asp Ile Val Leu Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Asn Tyr 
            20                  25                  30          


Gly Ile Ser Phe Met Ser Trp Phe Gln Gln Arg Pro Gly Gln Ser Pro 
        35                  40                  45              


Arg Leu Leu Ile Tyr Ala Ala Ser His Gln Gly Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser 
65                  70                  75                  80  


Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Leu Gln Ser Lys 
                85                  90                  95      


Glu Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110     


<210>  1992
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Domain (LC-344c)

<400>  1992

Asp Ile Val Leu Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Asn Tyr 
            20                  25                  30          


Gly Ile Ser Phe Met Ser Trp Phe Gln Gln Arg Pro Gly Gln Ser Pro 
        35                  40                  45              


Arg Leu Leu Ile Tyr Ala Ala Ser His Gln Gly Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser 
65                  70                  75                  80  


Arg Val Glu Ala Glu Asp Val Gly Val Tyr Phe Cys Leu Gln Ser Lys 
                85                  90                  95      


Glu Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110     


<210>  1993
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Domain (LC-344d)

<400>  1993

Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Asn Tyr 
            20                  25                  30          


Gly Ile Ser Phe Met Ser Trp Phe Gln Gln Arg Pro Gly Gln Ser Pro 
        35                  40                  45              


Arg Leu Leu Ile Tyr Ala Ala Ser His Gln Gly Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser 
65                  70                  75                  80  


Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Leu Gln Ser Lys 
                85                  90                  95      


Glu Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110     


<210>  1994
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Domain (LC-344e)

<400>  1994

Asp Val Val Leu Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Asn Tyr 
            20                  25                  30          


Gly Ile Ser Phe Met Ser Trp Phe Gln Gln Arg Pro Gly Gln Ser Pro 
        35                  40                  45              


Arg Leu Leu Ile Tyr Ala Ala Ser His Gln Gly Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser 
65                  70                  75                  80  


Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Leu Gln Ser Lys 
                85                  90                  95      


Glu Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110     


<210>  1995
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Domain (LC-344f)

<400>  1995

Asp Val Val Leu Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Asn Tyr 
            20                  25                  30          


Gly Ile Ser Phe Met Ser Trp Phe Gln Gln Arg Pro Gly Gln Ser Pro 
        35                  40                  45              


Arg Arg Leu Ile Tyr Ala Ala Ser His Gln Gly Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser 
65                  70                  75                  80  


Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Leu Gln Ser Lys 
                85                  90                  95      


Glu Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110     


<210>  1996
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Domain (LC-344g)

<400>  1996

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Asn Tyr 
            20                  25                  30          


Gly Ile Ser Phe Met Ser Trp Phe Gln Gln Arg Pro Gly Gln Ser Pro 
        35                  40                  45              


Arg Leu Leu Ile Tyr Ala Ala Ser His Gln Gly Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser 
65                  70                  75                  80  


Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Leu Gln Ser Lys 
                85                  90                  95      


Glu Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110     


<210>  1997
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Domain (LC-344h)

<400>  1997

Asp Val Val Leu Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Asn Tyr 
            20                  25                  30          


Gly Ile Ser Phe Met Ser Trp Phe Gln Gln Arg Pro Gly Gln Ser Pro 
        35                  40                  45              


Arg Leu Leu Ile Tyr Ala Ala Ser His Gln Gly Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser 
65                  70                  75                  80  


Arg Val Glu Ala Glu Asp Val Gly Val Tyr Phe Cys Leu Gln Ser Lys 
                85                  90                  95      


Glu Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110     


<210>  1998
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Domain (LC-344i)

<400>  1998

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Asn Tyr 
            20                  25                  30          


Gly Ile Ser Phe Met Ser Trp Phe Gln Gln Arg Pro Gly Gln Ser Pro 
        35                  40                  45              


Arg Leu Leu Ile Tyr Ala Ala Ser His Gln Gly Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser 
65                  70                  75                  80  


Arg Val Glu Ala Glu Asp Val Gly Val Tyr Phe Cys Leu Gln Ser Lys 
                85                  90                  95      


Glu Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110     


<210>  1999
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Domain (LC-345a)

<400>  1999

Asp Ile Glu Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Asn Tyr 
            20                  25                  30          


Gly Ile Ser Phe Met Ser Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Ala Ala Ser His Gln Gly Ser Gly Ile Pro Val 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Leu Gln Ser Lys 
                85                  90                  95      


Glu Val Pro Trp Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  2000
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Domain (LC-345b)

<400>  2000

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Asn Tyr 
            20                  25                  30          


Gly Ile Ser Phe Met Ser Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Ala Ala Ser His Gln Gly Ser Gly Ile Pro Val 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Leu Gln Ser Lys 
                85                  90                  95      


Glu Val Pro Trp Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  2001
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant Fc sequence

<400>  2001

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Ala Leu Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  2002
<211>  329
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant Fc sequence

<400>  2002

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Ala Leu Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly 
                325                 


<210>  2003
<211>  329
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant Fc sequence

<400>  2003

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly 
                325                 


<210>  2004
<211>  327
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant Fc sequence

<400>  2004

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 


Leu Ser Leu Ser Leu Gly Lys 
                325         


<210>  2005
<211>  326
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant Fc sequence

<400>  2005

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 


Leu Ser Leu Ser Leu Gly 
                325     


<210>  2006
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant Fc sequence

<400>  2006

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Gln Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  2007
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  kappa constant region (exemplary)

<400>  2007

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  2008
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lambda constant region (exemplary)

<400>  2008

Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
1               5                   10                  15      


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
            20                  25                  30          


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro 
        35                  40                  45              


Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn 
    50                  55                  60                  


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
65                  70                  75                  80  


Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
                85                  90                  95      


Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
            100                 105     


