               SEQUENCE LISTING

<110> DSM IP Assets B.V.

<120> ENZYME COMPOSITION AND PREPARATION OF A DAIRY PRODUCT WITH IMPROVED PROPERTIES

<130> 32082-WO-PCT

<150> US62/316369
<151> 2016-03-31

<160> 4

<170> BiSSAP 1.3.6

<210> 1
<211> 1752
<212> PRT
<213> Bifidobacterium bifidum


<400> 1
Met Ala Val Arg Arg Leu Gly Gly Arg Ile Val Ala Phe Ala Ala Thr 
1               5                   10                  15      
Val Ala Leu Ser Ile Pro Leu Gly Leu Leu Thr Asn Ser Ala Trp Ala 
            20                  25                  30          
Val Glu Asp Ala Thr Arg Ser Asp Ser Thr Thr Gln Met Ser Ser Thr 
        35                  40                  45              
Pro Glu Val Val Tyr Ser Ser Ala Val Asp Ser Lys Gln Asn Arg Thr 
    50                  55                  60                  
Ser Asp Phe Asp Ala Asn Trp Lys Phe Met Leu Ser Asp Ser Val Gln 
65                  70                  75                  80  
Ala Gln Asp Pro Ala Phe Asp Asp Ser Ala Trp Gln Gln Val Asp Leu 
                85                  90                  95      
Pro His Asp Tyr Ser Ile Thr Gln Lys Tyr Ser Gln Ser Asn Glu Ala 
            100                 105                 110         
Glu Ser Ala Tyr Leu Pro Gly Gly Thr Gly Trp Tyr Arg Lys Ser Phe 
        115                 120                 125             
Thr Ile Asp Arg Asp Leu Ala Gly Lys Arg Ile Ala Ile Asn Phe Asp 
    130                 135                 140                 
Gly Val Tyr Met Asn Ala Thr Val Trp Phe Asn Gly Val Lys Leu Gly 
145                 150                 155                 160 
Thr His Pro Tyr Gly Tyr Ser Pro Phe Ser Phe Asp Leu Thr Gly Asn 
                165                 170                 175     
Ala Lys Phe Gly Gly Glu Asn Thr Ile Val Val Lys Val Glu Asn Arg 
            180                 185                 190         
Leu Pro Ser Ser Arg Trp Tyr Ser Gly Ser Gly Ile Tyr Arg Asp Val 
        195                 200                 205             
Thr Leu Thr Val Thr Asp Gly Val His Val Gly Asn Asn Gly Val Ala 
    210                 215                 220                 
Ile Lys Thr Pro Ser Leu Ala Thr Gln Asn Gly Gly Asp Val Thr Met 
225                 230                 235                 240 
Asn Leu Thr Thr Lys Val Ala Asn Asp Thr Glu Ala Ala Ala Asn Ile 
                245                 250                 255     
Thr Leu Lys Gln Thr Val Phe Pro Lys Gly Gly Lys Thr Asp Ala Ala 
            260                 265                 270         
Ile Gly Thr Val Thr Thr Ala Ser Lys Ser Ile Ala Ala Gly Ala Ser 
        275                 280                 285             
Ala Asp Val Thr Ser Thr Ile Thr Ala Ala Ser Pro Lys Leu Trp Ser 
    290                 295                 300                 
Ile Lys Asn Pro Asn Leu Tyr Thr Val Arg Thr Glu Val Leu Asn Gly 
305                 310                 315                 320 
Gly Lys Val Leu Asp Thr Tyr Asp Thr Glu Tyr Gly Phe Arg Trp Thr 
                325                 330                 335     
Gly Phe Asp Ala Thr Ser Gly Phe Ser Leu Asn Gly Glu Lys Val Lys 
            340                 345                 350         
Leu Lys Gly Val Ser Met His His Asp Gln Gly Ser Leu Gly Ala Val 
        355                 360                 365             
Ala Asn Arg Arg Ala Ile Glu Arg Gln Val Glu Ile Leu Gln Lys Met 
    370                 375                 380                 
Gly Val Asn Ser Ile Arg Thr Thr His Asn Pro Ala Ala Lys Ala Leu 
385                 390                 395                 400 
Ile Asp Val Cys Asn Glu Lys Gly Val Leu Val Val Glu Glu Val Phe 
                405                 410                 415     
Asp Met Trp Asn Arg Ser Lys Asn Gly Asn Thr Glu Asp Tyr Gly Lys 
            420                 425                 430         
Trp Phe Gly Gln Ala Ile Ala Gly Asp Asn Ala Val Leu Gly Gly Asp 
        435                 440                 445             
Lys Asp Glu Thr Trp Ala Lys Phe Asp Leu Thr Ser Thr Ile Asn Arg 
    450                 455                 460                 
Asp Arg Asn Ala Pro Ser Val Ile Met Trp Ser Leu Gly Asn Glu Met 
465                 470                 475                 480 
Met Glu Gly Ile Ser Gly Ser Val Ser Gly Phe Pro Ala Thr Ser Ala 
                485                 490                 495     
Lys Leu Val Ala Trp Thr Lys Ala Ala Asp Ser Thr Arg Pro Met Thr 
            500                 505                 510         
Tyr Gly Asp Asn Lys Ile Lys Ala Asn Trp Asn Glu Ser Asn Thr Met 
        515                 520                 525             
Gly Asp Asn Leu Thr Ala Asn Gly Gly Val Val Gly Thr Asn Tyr Ser 
    530                 535                 540                 
Asp Gly Ala Asn Tyr Asp Lys Ile Arg Thr Thr His Pro Ser Trp Ala 
545                 550                 555                 560 
Ile Tyr Gly Ser Glu Thr Ala Ser Ala Ile Asn Ser Arg Gly Ile Tyr 
                565                 570                 575     
Asn Arg Thr Thr Gly Gly Ala Gln Ser Ser Asp Lys Gln Leu Thr Ser 
            580                 585                 590         
Tyr Asp Asn Ser Ala Val Gly Trp Gly Ala Val Ala Ser Ser Ala Trp 
        595                 600                 605             
Tyr Asp Val Val Gln Arg Asp Phe Val Ala Gly Thr Tyr Val Trp Thr 
    610                 615                 620                 
Gly Phe Asp Tyr Leu Gly Glu Pro Thr Pro Trp Asn Gly Thr Gly Ser 
625                 630                 635                 640 
Gly Ala Val Gly Ser Trp Pro Ser Pro Lys Asn Ser Tyr Phe Gly Ile 
                645                 650                 655     
Val Asp Thr Ala Gly Phe Pro Lys Asp Thr Tyr Tyr Phe Tyr Gln Ser 
            660                 665                 670         
Gln Trp Asn Asp Asp Val His Thr Leu His Ile Leu Pro Ala Trp Asn 
        675                 680                 685             
Glu Asn Val Val Ala Lys Gly Ser Gly Asn Asn Val Pro Val Val Val 
    690                 695                 700                 
Tyr Thr Asp Ala Ala Lys Val Lys Leu Tyr Phe Thr Pro Lys Gly Ser 
705                 710                 715                 720 
Thr Glu Lys Arg Leu Ile Gly Glu Lys Ser Phe Thr Lys Lys Thr Thr 
                725                 730                 735     
Ala Ala Gly Tyr Thr Tyr Gln Val Tyr Glu Gly Ser Asp Lys Asp Ser 
            740                 745                 750         
Thr Ala His Lys Asn Met Tyr Leu Thr Trp Asn Val Pro Trp Ala Glu 
        755                 760                 765             
Gly Thr Ile Ser Ala Glu Ala Tyr Asp Glu Asn Asn Arg Leu Ile Pro 
    770                 775                 780                 
Glu Gly Ser Thr Glu Gly Asn Ala Ser Val Thr Thr Thr Gly Lys Ala 
785                 790                 795                 800 
Ala Lys Leu Lys Ala Asp Ala Asp Arg Lys Thr Ile Thr Ala Asp Gly 
                805                 810                 815     
Lys Asp Leu Ser Tyr Ile Glu Val Asp Val Thr Asp Ala Asn Gly His 
            820                 825                 830         
Ile Val Pro Asp Ala Ala Asn Arg Val Thr Phe Asp Val Lys Gly Ala 
        835                 840                 845             
Gly Lys Leu Val Gly Val Asp Asn Gly Ser Ser Pro Asp His Asp Ser 
    850                 855                 860                 
Tyr Gln Ala Asp Asn Arg Lys Ala Phe Ser Gly Lys Val Leu Ala Ile 
865                 870                 875                 880 
Val Gln Ser Thr Lys Glu Ala Gly Glu Ile Thr Val Thr Ala Lys Ala 
                885                 890                 895     
Asp Gly Leu Gln Ser Ser Thr Val Lys Ile Ala Thr Thr Ala Val Pro 
            900                 905                 910         
Gly Thr Ser Thr Glu Lys Thr Val Arg Ser Phe Tyr Tyr Ser Arg Asn 
        915                 920                 925             
Tyr Tyr Val Lys Thr Gly Asn Lys Pro Ile Leu Pro Ser Asp Val Glu 
    930                 935                 940                 
Val Arg Tyr Ser Asp Gly Thr Ser Asp Arg Gln Asn Val Thr Trp Asp 
945                 950                 955                 960 
Ala Val Ser Asp Asp Gln Ile Ala Lys Ala Gly Ser Phe Ser Val Ala 
                965                 970                 975     
Gly Thr Val Ala Gly Gln Lys Ile Ser Val Arg Val Thr Met Ile Asp 
            980                 985                 990         
Glu Ile Gly Ala Leu Leu Asn Tyr Ser Ala Ser Thr Pro Val Gly Thr 
        995                 1000                1005            
Pro Ala Val Leu Pro Gly Ser Arg Pro Ala Val Leu Pro Asp Gly Thr 
    1010                1015                1020                
Val Thr Ser Ala Asn Phe Ala Val His Trp Thr Lys Pro Ala Asp Thr 
1025                1030                1035                1040
Val Tyr Asn Thr Ala Gly Thr Val Lys Val Pro Gly Thr Ala Thr Val 
                1045                1050                1055    
Phe Gly Lys Glu Phe Lys Val Thr Ala Thr Ile Arg Val Gln Arg Ser 
            1060                1065                1070        
Gln Val Thr Ile Gly Ser Ser Val Ser Gly Asn Ala Leu Arg Leu Thr 
        1075                1080                1085            
Gln Asn Ile Pro Ala Asp Lys Gln Ser Asp Thr Leu Asp Ala Ile Lys 
    1090                1095                1100                
Asp Gly Ser Thr Thr Val Asp Ala Asn Thr Gly Gly Gly Ala Asn Pro 
1105                1110                1115                1120
Ser Ala Trp Thr Asn Trp Ala Tyr Ser Lys Ala Gly His Asn Thr Ala 
                1125                1130                1135    
Glu Ile Thr Phe Glu Tyr Ala Thr Glu Gln Gln Leu Gly Gln Ile Val 
            1140                1145                1150        
Met Tyr Phe Phe Arg Asp Ser Asn Ala Val Arg Phe Pro Asp Ala Gly 
        1155                1160                1165            
Lys Thr Lys Ile Gln Ile Ser Ala Asp Gly Lys Asn Trp Thr Asp Leu 
    1170                1175                1180                
Ala Ala Thr Glu Thr Ile Ala Ala Gln Glu Ser Ser Asp Arg Val Lys 
1185                1190                1195                1200
Pro Tyr Thr Tyr Asp Phe Ala Pro Val Gly Ala Thr Phe Val Lys Val 
                1205                1210                1215    
Thr Val Thr Asn Ala Asp Thr Thr Thr Pro Ser Gly Val Val Cys Ala 
            1220                1225                1230        
Gly Leu Thr Glu Ile Glu Leu Lys Thr Ala Thr Ser Lys Phe Val Thr 
        1235                1240                1245            
Asn Thr Ser Ala Ala Leu Ser Ser Leu Thr Val Asn Gly Thr Lys Val 
    1250                1255                1260                
Ser Asp Ser Val Leu Ala Ala Gly Ser Tyr Asn Thr Pro Ala Ile Ile 
1265                1270                1275                1280
Ala Asp Val Lys Ala Glu Gly Glu Gly Asn Ala Ser Val Thr Val Leu 
                1285                1290                1295    
Pro Ala His Asp Asn Val Ile Arg Val Ile Thr Glu Ser Glu Asp His 
            1300                1305                1310        
Val Thr Arg Lys Thr Phe Thr Ile Asn Leu Gly Thr Glu Gln Glu Phe 
        1315                1320                1325            
Pro Ala Asp Ser Asp Glu Arg Asp Tyr Pro Ala Ala Asp Met Thr Val 
    1330                1335                1340                
Thr Val Gly Ser Glu Gln Thr Ser Gly Thr Ala Thr Glu Gly Pro Lys 
1345                1350                1355                1360
Lys Phe Ala Val Asp Gly Asn Thr Ser Thr Tyr Trp His Ser Asn Trp 
                1365                1370                1375    
Thr Pro Thr Thr Val Asn Asp Leu Trp Ile Ala Phe Glu Leu Gln Lys 
            1380                1385                1390        
Pro Thr Lys Leu Asp Ala Leu Arg Tyr Leu Pro Arg Pro Ala Gly Ser 
        1395                1400                1405            
Lys Asn Gly Ser Val Thr Glu Tyr Lys Val Gln Val Ser Asp Asp Gly 
    1410                1415                1420                
Thr Asn Trp Thr Asp Ala Gly Ser Gly Thr Trp Thr Thr Asp Tyr Gly 
1425                1430                1435                1440
Trp Lys Leu Ala Glu Phe Asn Gln Pro Val Thr Thr Lys His Val Arg 
                1445                1450                1455    
Leu Lys Ala Val His Thr Tyr Ala Asp Ser Gly Asn Asp Lys Phe Met 
            1460                1465                1470        
Ser Ala Ser Glu Ile Arg Leu Arg Lys Ala Val Asp Thr Thr Asp Ile 
        1475                1480                1485            
Ser Gly Ala Thr Val Thr Val Pro Ala Lys Leu Thr Val Asp Arg Val 
    1490                1495                1500                
Asp Ala Asp His Pro Ala Thr Phe Ala Thr Lys Asp Val Thr Val Thr 
1505                1510                1515                1520
Leu Gly Asp Ala Thr Leu Arg Tyr Gly Val Asp Tyr Leu Leu Asp Tyr 
                1525                1530                1535    
Ala Gly Asn Thr Ala Val Gly Lys Ala Thr Val Thr Val Arg Gly Ile 
            1540                1545                1550        
Asp Lys Tyr Ser Gly Thr Val Ala Lys Thr Phe Thr Ile Glu Leu Lys 
        1555                1560                1565            
Asn Ala Pro Ala Pro Glu Pro Thr Leu Thr Ser Val Ser Val Lys Thr 
    1570                1575                1580                
Lys Pro Ser Lys Leu Thr Tyr Val Val Gly Asp Ala Phe Asp Pro Ala 
1585                1590                1595                1600
Gly Leu Val Leu Gln His Asp Arg Gln Ala Asp Arg Pro Pro Gln Pro 
                1605                1610                1615    
Leu Val Gly Glu Gln Ala Asp Glu Arg Gly Leu Thr Cys Gly Thr Arg 
            1620                1625                1630        
Cys Asp Arg Val Glu Gln Leu Arg Lys His Glu Asn Arg Glu Ala His 
        1635                1640                1645            
Arg Thr Gly Leu Asp His Leu Glu Phe Val Gly Ala Ala Asp Gly Ala 
    1650                1655                1660                
Val Gly Glu Gln Ala Thr Phe Lys Val His Val His Ala Asp Gln Gly 
1665                1670                1675                1680
Asp Gly Arg His Asp Asp Ala Asp Glu Arg Asp Ile Asp Pro His Val 
                1685                1690                1695    
Pro Val Asp His Ala Val Gly Glu Leu Ala Arg Ala Ala Cys His His 
            1700                1705                1710        
Val Ile Gly Leu Arg Val Asp Thr His Arg Leu Lys Ala Ser Gly Phe 
        1715                1720                1725            
Gln Ile Pro Ala Asp Asp Met Ala Glu Ile Asp Arg Ile Thr Gly Phe 
    1730                1735                1740                
His Arg Phe Glu Arg His Val Gly 
1745                1750        

<210> 2
<211> 1935
<212> PRT
<213> Bifidobacterium bifidum


<400> 2
Met Ala Val Arg Arg Leu Gly Gly Arg Ile Val Ala Phe Ala Ala Thr 
1               5                   10                  15      
Val Ala Leu Ser Ile Pro Leu Gly Leu Leu Thr Asn Ser Ala Trp Ala 
            20                  25                  30          
Val Glu Asp Ala Thr Arg Ser Asp Ser Thr Thr Gln Met Ser Ser Thr 
        35                  40                  45              
Pro Glu Val Val Tyr Ser Ser Ala Val Asp Ser Lys Gln Asn Arg Thr 
    50                  55                  60                  
Ser Asp Phe Asp Ala Asn Trp Lys Phe Met Leu Ser Asp Ser Val Gln 
65                  70                  75                  80  
Ala Gln Asp Pro Ala Phe Asp Asp Ser Ala Trp Gln Gln Val Asp Leu 
                85                  90                  95      
Pro His Asp Tyr Ser Ile Thr Gln Lys Tyr Ser Gln Ser Asn Glu Ala 
            100                 105                 110         
Glu Ser Ala Tyr Leu Pro Gly Gly Thr Gly Trp Tyr Arg Lys Ser Phe 
        115                 120                 125             
Thr Ile Asp Arg Asp Leu Ala Gly Lys Arg Ile Ala Ile Asn Phe Asp 
    130                 135                 140                 
Gly Val Tyr Met Asn Ala Thr Val Trp Phe Asn Gly Val Lys Leu Gly 
145                 150                 155                 160 
Thr His Pro Tyr Gly Tyr Ser Pro Phe Ser Phe Asp Leu Thr Gly Asn 
                165                 170                 175     
Ala Lys Phe Gly Gly Glu Asn Thr Ile Val Val Lys Val Glu Asn Arg 
            180                 185                 190         
Leu Pro Ser Ser Arg Trp Tyr Ser Gly Ser Gly Ile Tyr Arg Asp Val 
        195                 200                 205             
Thr Leu Thr Val Thr Asp Gly Val His Val Gly Asn Asn Gly Val Ala 
    210                 215                 220                 
Ile Lys Thr Pro Ser Leu Ala Thr Gln Asn Gly Gly Asn Val Thr Met 
225                 230                 235                 240 
Asn Leu Thr Thr Lys Val Ala Asn Asp Thr Lys Ala Ala Ala Asn Ile 
                245                 250                 255     
Thr Leu Lys Gln Thr Val Phe Pro Lys Gly Gly Lys Thr Asp Ala Ala 
            260                 265                 270         
Ile Gly Thr Val Thr Thr Ala Ser Lys Ser Ile Ala Ala Gly Ala Ser 
        275                 280                 285             
Ala Asp Val Thr Ser Thr Ile Thr Ala Ala Ser Pro Lys Leu Trp Ser 
    290                 295                 300                 
Ile Lys Asn Pro Asn Leu Tyr Thr Val Arg Thr Glu Val Leu Asn Gly 
305                 310                 315                 320 
Gly Lys Val Leu Asp Thr Tyr Asp Thr Glu Tyr Gly Phe Arg Trp Thr 
                325                 330                 335     
Gly Phe Asp Ala Thr Ser Gly Phe Ser Leu Asn Gly Glu Lys Val Lys 
            340                 345                 350         
Leu Lys Gly Val Ser Met His His Asp Gln Gly Ser Leu Gly Ala Val 
        355                 360                 365             
Ala Asn Arg Arg Ala Ile Glu Arg Gln Val Glu Ile Leu Gln Lys Met 
    370                 375                 380                 
Gly Val Asn Ser Ile Arg Thr Thr His Asn Pro Ala Ala Lys Ala Leu 
385                 390                 395                 400 
Ile Asp Val Cys Asn Glu Lys Gly Val Leu Val Val Glu Glu Val Phe 
                405                 410                 415     
Asp Met Trp Asn Arg Ser Lys Asn Gly Asn Thr Glu Asp Tyr Gly Lys 
            420                 425                 430         
Trp Phe Gly Gln Ala Ile Ala Gly Asp Asn Ala Val Leu Gly Gly Asp 
        435                 440                 445             
Lys Asp Glu Thr Trp Ala Lys Phe Asp Leu Thr Ser Thr Ile Asn Arg 
    450                 455                 460                 
Asp Arg Asn Ala Pro Ser Val Ile Met Trp Ser Leu Gly Asn Glu Met 
465                 470                 475                 480 
Met Glu Gly Ile Ser Gly Ser Val Ser Gly Phe Pro Ala Thr Ser Ala 
                485                 490                 495     
Lys Leu Val Ala Trp Thr Lys Ala Ala Asp Ser Thr Arg Pro Met Thr 
            500                 505                 510         
Tyr Gly Asp Asn Lys Ile Lys Ala Asn Trp Asn Glu Ser Asn Thr Met 
        515                 520                 525             
Gly Asp Asn Leu Thr Ala Asn Gly Gly Val Val Gly Thr Asn Tyr Ser 
    530                 535                 540                 
Asp Gly Ala Asn Tyr Asp Lys Ile Arg Thr Thr His Pro Ser Trp Ala 
545                 550                 555                 560 
Ile Tyr Gly Ser Glu Thr Ala Ser Ala Ile Asn Ser Arg Gly Ile Tyr 
                565                 570                 575     
Asn Arg Thr Thr Gly Gly Ala Gln Ser Ser Asp Lys Gln Leu Thr Ser 
            580                 585                 590         
Tyr Asp Asn Ser Ala Val Gly Trp Gly Ala Val Ala Ser Ser Ala Trp 
        595                 600                 605             
Tyr Asp Val Val Gln Arg Asp Phe Val Ala Gly Thr Tyr Val Trp Thr 
    610                 615                 620                 
Gly Phe Asp Tyr Leu Gly Glu Pro Thr Pro Trp Asn Gly Thr Gly Ser 
625                 630                 635                 640 
Gly Ala Val Gly Ser Trp Pro Ser Pro Lys Asn Ser Tyr Phe Gly Ile 
                645                 650                 655     
Val Asp Thr Ala Gly Phe Pro Lys Asp Thr Tyr Tyr Phe Tyr Gln Ser 
            660                 665                 670         
Gln Trp Asn Asp Asp Val His Thr Leu His Ile Leu Pro Ala Trp Asn 
        675                 680                 685             
Glu Asn Val Val Ala Lys Gly Ser Gly Asn Asn Val Pro Val Val Val 
    690                 695                 700                 
Tyr Thr Asp Ala Ala Lys Val Lys Leu Tyr Phe Thr Pro Lys Gly Ser 
705                 710                 715                 720 
Thr Glu Lys Arg Leu Ile Gly Glu Lys Ser Phe Thr Lys Lys Thr Thr 
                725                 730                 735     
Ala Ala Gly Tyr Thr Tyr Gln Val Tyr Glu Gly Ala Asp Lys Asp Ser 
            740                 745                 750         
Thr Ala His Lys Asn Met Tyr Leu Thr Trp Asn Val Pro Trp Ala Glu 
        755                 760                 765             
Gly Thr Ile Ser Ala Glu Ala Tyr Asp Glu Asn Asn Arg Leu Ile Pro 
    770                 775                 780                 
Glu Gly Ser Thr Glu Gly Asn Ala Ser Val Thr Thr Thr Gly Lys Ala 
785                 790                 795                 800 
Ala Lys Leu Lys Ala Asp Ala Asp Arg Lys Thr Ile Thr Ala Asp Gly 
                805                 810                 815     
Lys Asp Leu Ser Tyr Ile Glu Val Asp Val Thr Asp Ala Asn Gly His 
            820                 825                 830         
Ile Val Pro Asp Ala Ala Asn Arg Val Thr Phe Asp Val Lys Gly Ala 
        835                 840                 845             
Gly Lys Leu Val Gly Val Asp Asn Gly Ser Ser Pro Asp His Asp Ser 
    850                 855                 860                 
Tyr Gln Ala Asp Asn Arg Lys Ala Phe Ser Gly Lys Val Leu Ala Ile 
865                 870                 875                 880 
Val Gln Ser Thr Lys Glu Ala Gly Glu Ile Thr Val Thr Ala Lys Ala 
                885                 890                 895     
Asp Gly Leu Gln Ser Ser Thr Val Lys Ile Ala Thr Thr Ala Val Pro 
            900                 905                 910         
Gly Thr Ser Thr Glu Lys Thr Val Arg Ser Phe Tyr Tyr Ser Arg Asn 
        915                 920                 925             
Tyr Tyr Val Lys Thr Gly Asn Lys Pro Ile Leu Pro Ser Asp Val Glu 
    930                 935                 940                 
Val Arg Tyr Ser Asp Gly Thr Ser Asp Arg Gln Asn Val Thr Trp Asp 
945                 950                 955                 960 
Ala Val Ser Asp Asp Gln Ile Ala Lys Ala Gly Ser Phe Ser Val Ala 
                965                 970                 975     
Gly Thr Val Ala Gly Gln Lys Ile Ser Val Arg Val Thr Met Ile Asp 
            980                 985                 990         
Glu Ile Gly Ala Leu Leu Asn Tyr Ser Ala Ser Thr Pro Val Gly Thr 
        995                 1000                1005            
Pro Ala Val Leu Pro Gly Ser Arg Pro Ala Val Leu Pro Asp Gly Thr 
    1010                1015                1020                
Val Thr Ser Ala Asn Phe Ala Val Asp Trp Thr Lys Pro Ala Asp Thr 
1025                1030                1035                1040
Val Tyr Asn Thr Ala Gly Thr Val Lys Val Pro Gly Thr Ala Thr Val 
                1045                1050                1055    
Phe Gly Lys Glu Phe Lys Val Thr Ala Thr Ile Arg Val Gln Arg Ser 
            1060                1065                1070        
Gln Val Thr Ile Gly Ser Ser Val Ser Gly Asn Ala Leu Arg Leu Thr 
        1075                1080                1085            
Gln Asn Ile Pro Ala Asp Lys Gln Ser Asp Thr Leu Asp Ala Ile Lys 
    1090                1095                1100                
Asp Gly Ser Thr Thr Val Asp Ala Asn Thr Gly Gly Gly Ala Asn Pro 
1105                1110                1115                1120
Ser Ala Trp Thr Asn Trp Ala Tyr Ser Lys Ala Gly His Asn Thr Ala 
                1125                1130                1135    
Glu Ile Thr Phe Glu Tyr Ala Thr Glu Gln Gln Leu Gly Gln Ile Val 
            1140                1145                1150        
Met Tyr Phe Phe Arg Asp Ser Asn Ala Val Arg Phe Pro Asp Ala Gly 
        1155                1160                1165            
Lys Thr Lys Ile Gln Ile Ser Ala Asp Gly Lys Asn Trp Thr Asp Leu 
    1170                1175                1180                
Ala Ala Thr Glu Thr Ile Ala Ala Gln Glu Ser Ser Asp Arg Val Lys 
1185                1190                1195                1200
Pro Tyr Thr Tyr Asp Phe Ala Pro Val Gly Ala Thr Phe Val Lys Val 
                1205                1210                1215    
Thr Val Thr Asn Ala Asp Thr Thr Thr Pro Ser Gly Val Val Cys Ala 
            1220                1225                1230        
Gly Leu Thr Glu Ile Glu Leu Lys Thr Ala Thr Ser Lys Phe Val Thr 
        1235                1240                1245            
Asn Thr Ser Ala Ala Leu Ser Ser Leu Thr Val Asn Gly Thr Lys Val 
    1250                1255                1260                
Ser Asp Ser Val Leu Ala Ala Gly Ser Tyr Asn Thr Pro Ala Ile Ile 
1265                1270                1275                1280
Ala Asp Val Lys Ala Glu Gly Glu Gly Asn Ala Ser Val Thr Val Leu 
                1285                1290                1295    
Pro Ala His Asp Asn Val Ile Arg Val Ile Thr Glu Ser Glu Asp His 
            1300                1305                1310        
Val Thr Arg Lys Thr Phe Thr Ile Asn Leu Gly Thr Glu Gln Glu Phe 
        1315                1320                1325            
Pro Ala Asp Ser Asp Glu Arg Asp Tyr Pro Ala Ala Asp Met Thr Val 
    1330                1335                1340                
Thr Ala Gly Ser Glu Gln Thr Ser Gly Thr Ala Thr Glu Gly Pro Lys 
1345                1350                1355                1360
Lys Phe Ala Val Asp Gly Asn Thr Ser Thr Tyr Trp His Ser Asn Trp 
                1365                1370                1375    
Thr Pro Thr Thr Val Asn Asp Leu Trp Ile Ala Phe Glu Leu Gln Lys 
            1380                1385                1390        
Pro Thr Lys Leu Asp Ala Leu Arg Tyr Leu Pro Arg Pro Ala Gly Ser 
        1395                1400                1405            
Lys Asn Gly Ser Val Thr Glu Tyr Lys Val Gln Val Ser Asp Asp Gly 
    1410                1415                1420                
Thr Asn Trp Thr Asp Ala Gly Ser Gly Thr Trp Thr Thr Asp Tyr Gly 
1425                1430                1435                1440
Trp Lys Leu Ala Glu Phe Asn Gln Pro Val Thr Thr Lys His Val Arg 
                1445                1450                1455    
Leu Lys Ala Val His Thr Tyr Ala Asp Ser Gly Asn Asp Lys Phe Met 
            1460                1465                1470        
Ser Ala Ser Glu Ile Arg Leu Arg Lys Ala Val Asp Thr Thr Asp Ile 
        1475                1480                1485            
Ser Gly Ala Thr Val Thr Val Pro Ala Lys Leu Thr Val Asp Arg Val 
    1490                1495                1500                
Asp Ala Asp His Pro Ala Thr Phe Ala Thr Lys Asp Val Thr Val Thr 
1505                1510                1515                1520
Leu Gly Asp Ala Thr Leu Arg Tyr Gly Val Asp Tyr Leu Leu Asp Tyr 
                1525                1530                1535    
Ala Gly Asn Thr Ala Val Gly Lys Ala Thr Val Thr Val Arg Gly Ile 
            1540                1545                1550        
Asp Lys Tyr Ser Gly Thr Val Ala Lys Thr Phe Thr Ile Glu Leu Lys 
        1555                1560                1565            
Asn Ala Pro Ala Pro Glu Pro Thr Leu Thr Ser Val Ser Val Lys Thr 
    1570                1575                1580                
Lys Pro Ser Lys Leu Thr Tyr Val Val Gly Asp Ala Phe Asp Pro Ala 
1585                1590                1595                1600
Gly Leu Val Leu Gln Leu Asn Tyr Asp Asp Asp Ser Thr Gly Thr Val 
                1605                1610                1615    
Thr Trp Asn Thr Gln Thr Ala Gly Asp Phe Thr Phe Lys Pro Ala Leu 
            1620                1625                1630        
Asp Ala Lys Leu Lys Val Thr Asp Lys Thr Val Thr Val Thr Tyr Gln 
        1635                1640                1645            
Gly Lys Ser Ala Val Ile Asp Ile Thr Val Ser Gln Pro Ala Pro Thr 
    1650                1655                1660                
Val Ser Lys Thr Asp Leu Asp Lys Ala Ile Lys Ala Ile Glu Ala Lys 
1665                1670                1675                1680
Asn Pro Asp Ser Ser Lys Tyr Thr Ala Asp Ser Trp Lys Thr Phe Ala 
                1685                1690                1695    
Asp Ala Met Ala His Ala Lys Ala Val Ile Ala Asp Asp Ser Ala Thr 
            1700                1705                1710        
Gln Gln Asp Val Asp Lys Ala Leu Lys Ala Leu Thr Asp Ala Tyr Ala 
        1715                1720                1725            
Gly Leu Thr Glu Lys Thr Pro Glu Pro Ala Pro Val Ser Lys Ser Glu 
    1730                1735                1740                
Leu Asp Lys Lys Ile Lys Ala Ile Glu Ala Glu Lys Leu Asp Gly Ser 
1745                1750                1755                1760
Lys Tyr Thr Ala Glu Ser Trp Lys Ala Phe Glu Thr Ala Leu Ala His 
                1765                1770                1775    
Ala Lys Ala Val Ile Ala Ser Asp Ser Ala Thr Gln Gln Asp Val Asp 
            1780                1785                1790        
Ala Ala Leu Gly Ala Leu Thr Ser Ala Arg Asp Gly Leu Thr Glu Lys 
        1795                1800                1805            
Gly Glu Val Lys Pro Asp Pro Lys Pro Glu Pro Gly Thr Val Asp Lys 
    1810                1815                1820                
Ala Ala Leu Asp Lys Ala Val Lys Lys Val Glu Ala Glu Lys Leu Asp 
1825                1830                1835                1840
Gly Ser Lys Tyr Thr Ala Asp Ser Trp Lys Ala Phe Glu Thr Ala Leu 
                1845                1850                1855    
Ala His Ala Lys Ala Val Ile Gly Asn Ala Asn Ser Thr Gln Phe Asp 
            1860                1865                1870        
Ile Asp Asn Ala Leu Ser Met Leu Asn Asp Ala Arg Ala Ala Leu Lys 
        1875                1880                1885            
Glu Lys Pro Gly Arg Ile Ile Ala Ile Ile Asp Gly Gly Ala Leu Ser 
    1890                1895                1900                
Lys Thr Gly Ala Ser Val Ala Ile Ile Ala Ser Val Ala Ala Ala Met 
1905                1910                1915                1920
Lys Ala Val Gly Ala Gly Val Met Ala Leu Arg Pro Pro Lys Trp 
                1925                1930                1935

<210> 3
<211> 1341
<212> PRT
<213> Bifidobacterium bifidum


<400> 3
Met Lys Lys Pro Leu Gly Lys Ile Val Ala Ser Thr Ala Leu Leu Ile 
1               5                   10                  15      
Ser Val Ala Phe Ser Ser Ser Ile Ala Ser Ala Ile Glu Asp Ala Thr 
            20                  25                  30          
Arg Ser Asp Ser Thr Thr Gln Met Ser Ser Thr Pro Glu Val Ala Tyr 
        35                  40                  45              
Ser Ser Ala Val Asp Ser Lys Gln Asn Arg Thr Ser Asp Phe Asp Ala 
    50                  55                  60                  
Asn Trp Lys Phe Met Leu Ser Asp Ser Val Gln Ala Gln Asp Pro Ala 
65                  70                  75                  80  
Phe Asp Asp Ser Ala Trp Gln Gln Val Asp Leu Pro His Asp Tyr Ser 
                85                  90                  95      
Ile Thr Gln Lys Tyr Ser Gln Ser Asn Glu Ala Glu Ser Ala Tyr Leu 
            100                 105                 110         
Pro Gly Gly Thr Gly Trp Tyr Arg Lys Ser Phe Thr Ile Asp Arg Asp 
        115                 120                 125             
Leu Ala Gly Lys Arg Ile Ala Ile Asn Phe Asp Gly Val Tyr Met Asn 
    130                 135                 140                 
Ala Thr Val Trp Phe Asn Gly Val Lys Leu Gly Thr His Pro Tyr Gly 
145                 150                 155                 160 
Tyr Ser Pro Phe Ser Phe Asp Leu Thr Gly Asn Ala Lys Phe Gly Gly 
                165                 170                 175     
Glu Asn Thr Ile Val Val Lys Val Glu Asn Arg Leu Pro Ser Ser Arg 
            180                 185                 190         
Trp Tyr Ser Gly Ser Gly Ile Tyr Arg Asp Val Thr Leu Thr Val Thr 
        195                 200                 205             
Asp Gly Val His Val Gly Asn Asn Gly Val Ala Ile Lys Thr Pro Ser 
    210                 215                 220                 
Leu Ala Thr Gln Asn Gly Gly Asp Val Thr Met Asn Leu Thr Thr Lys 
225                 230                 235                 240 
Val Ala Asn Asp Thr Glu Ala Ala Ala Asn Ile Thr Leu Lys Gln Thr 
                245                 250                 255     
Val Phe Pro Lys Gly Gly Lys Thr Asp Ala Ala Ile Gly Thr Val Thr 
            260                 265                 270         
Thr Ala Ser Lys Ser Ile Ala Ala Gly Ala Ser Ala Asp Val Thr Ser 
        275                 280                 285             
Thr Ile Thr Ala Ala Ser Pro Lys Leu Trp Ser Ile Lys Asn Pro Asn 
    290                 295                 300                 
Leu Tyr Thr Val Arg Thr Glu Val Leu Asn Gly Gly Lys Val Leu Asp 
305                 310                 315                 320 
Thr Tyr Asp Thr Glu Tyr Gly Phe Arg Trp Thr Gly Phe Asp Ala Thr 
                325                 330                 335     
Ser Gly Phe Ser Leu Asn Gly Glu Lys Val Lys Leu Lys Gly Val Ser 
            340                 345                 350         
Met His His Asp Gln Gly Ser Leu Gly Ala Val Ala Asn Arg Arg Ala 
        355                 360                 365             
Ile Glu Arg Gln Val Glu Ile Leu Gln Lys Met Gly Val Asn Ser Ile 
    370                 375                 380                 
Arg Thr Thr His Asn Pro Ala Ala Lys Ala Leu Ile Asp Val Cys Asn 
385                 390                 395                 400 
Glu Lys Gly Val Leu Val Val Glu Glu Val Phe Asp Met Trp Asn Arg 
                405                 410                 415     
Ser Lys Asn Gly Asn Thr Glu Asp Tyr Gly Lys Trp Phe Gly Gln Ala 
            420                 425                 430         
Ile Ala Gly Asp Asn Ala Val Leu Gly Gly Asp Lys Asp Glu Thr Trp 
        435                 440                 445             
Ala Lys Phe Asp Leu Thr Ser Thr Ile Asn Arg Asp Arg Asn Ala Pro 
    450                 455                 460                 
Ser Val Ile Met Trp Ser Leu Gly Asn Glu Met Met Glu Gly Ile Ser 
465                 470                 475                 480 
Gly Ser Val Ser Gly Phe Ser Ala Thr Ser Ala Lys Leu Val Ala Trp 
                485                 490                 495     
Thr Lys Ala Ala Asp Ser Thr Arg Pro Met Thr Tyr Gly Asp Asn Lys 
            500                 505                 510         
Ile Lys Ala Asn Trp Asn Glu Ser Asn Thr Met Gly Asp Asn Leu Thr 
        515                 520                 525             
Ala Asn Gly Gly Val Val Gly Thr Asn Tyr Ser Asp Gly Ala Asn Tyr 
    530                 535                 540                 
Asp Lys Ile Arg Thr Thr His Pro Ser Trp Ala Ile Tyr Gly Ser Glu 
545                 550                 555                 560 
Thr Ala Ser Ala Ile Asn Ser Arg Gly Ile Tyr Asn Arg Thr Thr Gly 
                565                 570                 575     
Gly Ala Gln Ser Ser Asp Lys Gln Leu Thr Ser Tyr Asp Asn Ser Ala 
            580                 585                 590         
Val Gly Trp Gly Ala Val Ala Ser Ser Ala Trp Tyr Asp Val Val Gln 
        595                 600                 605             
Arg Asp Phe Val Ala Gly Thr Tyr Val Trp Thr Gly Phe Asp Tyr Leu 
    610                 615                 620                 
Gly Glu Pro Thr Pro Trp Asn Gly Thr Gly Ser Gly Ala Val Gly Ser 
625                 630                 635                 640 
Trp Pro Ser Pro Lys Asn Ser Tyr Phe Gly Ile Val Asp Thr Ala Gly 
                645                 650                 655     
Phe Pro Lys Asp Thr Tyr Tyr Phe Tyr Gln Ser Gln Trp Asn Asp Asp 
            660                 665                 670         
Val His Thr Leu His Ile Leu Pro Ala Trp Asn Glu Asn Val Val Ala 
        675                 680                 685             
Lys Gly Ser Gly Asn Asn Val Pro Val Val Val Tyr Thr Asp Ala Ala 
    690                 695                 700                 
Lys Val Lys Leu Tyr Phe Thr Pro Lys Gly Ser Thr Glu Gln Arg Leu 
705                 710                 715                 720 
Ile Gly Glu Lys Ser Phe Thr Lys Lys Thr Thr Ala Ala Gly Tyr Thr 
                725                 730                 735     
Tyr Gln Val Tyr Glu Gly Ser Asp Lys Asp Ser Thr Ala His Lys Asn 
            740                 745                 750         
Met Tyr Leu Thr Trp Asn Val Pro Trp Ala Glu Gly Thr Ile Ser Ala 
        755                 760                 765             
Glu Ala Tyr Asp Glu Asn Asn Arg Leu Ile Pro Glu Gly Ser Thr Glu 
    770                 775                 780                 
Gly Asn Ala Ser Val Thr Thr Thr Gly Lys Ala Ala Lys Leu Lys Ala 
785                 790                 795                 800 
Asp Ala Asp Arg Lys Thr Ile Thr Ala Asp Gly Lys Asp Leu Ser Tyr 
                805                 810                 815     
Ile Glu Val Asp Val Thr Asp Ala Asn Gly His Ile Val Pro Asp Ala 
            820                 825                 830         
Ala Asn Arg Val Thr Phe Asp Val Lys Gly Ala Gly Lys Leu Val Gly 
        835                 840                 845             
Val Asp Asn Gly Ser Ser Pro Asp His Asp Ser Tyr Gln Ala Asp Asn 
    850                 855                 860                 
Arg Lys Ala Phe Ser Gly Lys Val Leu Ala Ile Val Gln Ser Thr Lys 
865                 870                 875                 880 
Glu Ala Gly Glu Ile Thr Val Thr Ala Lys Ala Asp Gly Leu Gln Ser 
                885                 890                 895     
Ser Thr Val Lys Ile Ala Thr Thr Ala Val Pro Gly Thr Ser Thr Glu 
            900                 905                 910         
Lys Thr Val Arg Ser Phe Tyr Tyr Ser Arg Asn Tyr Tyr Val Lys Thr 
        915                 920                 925             
Gly Asn Lys Pro Ile Leu Pro Ser Asp Val Glu Val Arg Tyr Ser Asp 
    930                 935                 940                 
Gly Thr Ser Asp Arg Gln Asn Val Thr Trp Asp Ala Val Ser Asp Asp 
945                 950                 955                 960 
Gln Ile Ala Lys Ala Gly Ser Phe Ser Val Ala Gly Thr Val Ala Gly 
                965                 970                 975     
Gln Lys Ile Ser Val Arg Val Thr Met Ile Asp Glu Ile Gly Ala Leu 
            980                 985                 990         
Leu Asn Tyr Ser Ala Ser Thr Pro Val Gly Thr Pro Ala Val Leu Pro 
        995                 1000                1005            
Gly Ser Arg Pro Ala Val Leu Pro Asp Gly Thr Val Thr Ser Ala Asn 
    1010                1015                1020                
Phe Ala Val His Trp Thr Lys Pro Ala Asp Thr Val Tyr Asn Thr Ala 
1025                1030                1035                1040
Gly Thr Val Lys Val Pro Gly Thr Ala Thr Val Phe Gly Lys Glu Phe 
                1045                1050                1055    
Lys Val Thr Ala Thr Ile Arg Val Gln Arg Ser Gln Val Thr Ile Gly 
            1060                1065                1070        
Ser Ser Val Ser Gly Asn Ala Leu Arg Leu Thr Gln Asn Ile Pro Ala 
        1075                1080                1085            
Asp Lys Gln Ser Asp Thr Leu Asp Ala Ile Lys Asp Gly Ser Thr Thr 
    1090                1095                1100                
Val Asp Ala Asn Thr Gly Gly Gly Ala Asn Pro Ser Ala Trp Thr Asn 
1105                1110                1115                1120
Trp Ala Tyr Ser Lys Ala Gly His Asn Thr Ala Glu Ile Thr Phe Glu 
                1125                1130                1135    
Tyr Ala Thr Glu Gln Gln Leu Gly Gln Ile Val Met Tyr Phe Phe Arg 
            1140                1145                1150        
Asp Ser Asn Ala Val Arg Phe Pro Asp Ala Gly Lys Thr Lys Ile Gln 
        1155                1160                1165            
Ile Ser Ala Asp Gly Lys Asn Trp Thr Asp Leu Ala Ala Thr Glu Thr 
    1170                1175                1180                
Ile Ala Ala Gln Glu Ser Ser Asp Arg Val Lys Pro Tyr Thr Tyr Asp 
1185                1190                1195                1200
Phe Ala Pro Val Gly Ala Thr Phe Val Arg Val Thr Val Thr Asn Ala 
                1205                1210                1215    
Asp Thr Thr Thr Pro Ser Gly Val Val Cys Ala Gly Leu Thr Glu Ile 
            1220                1225                1230        
Glu Leu Lys Thr Ala Thr Ser Lys Phe Val Ala Asn Thr Ser Ala Ala 
        1235                1240                1245            
Leu Ser Ser Leu Thr Val Asn Gly Thr Lys Val Ser Asp Ser Val Leu 
    1250                1255                1260                
Ala Ala Gly Ser Tyr Asn Thr Pro Ala Ile Ile Ala Asp Val Lys Ala 
1265                1270                1275                1280
Glu Gly Glu Gly Asn Ala Ser Val Thr Val Leu Pro Ala His Asp Asn 
                1285                1290                1295    
Val Ile Arg Val Ile Thr Glu Ser Glu Asp His Val Thr Arg Lys Thr 
            1300                1305                1310        
Phe Thr Ile Asn Leu Gly Thr Glu Gln Glu Phe Pro Ala Asp Ser Asp 
        1315                1320                1325            
Glu Arg Asp Gln His Gln His Gln His Gln His Gln Gln 
    1330                1335                1340    

<210> 4
<211> 1331
<212> PRT
<213> Bifidobacterium bifidum


<400> 4
Met Lys Lys Pro Leu Gly Lys Ile Val Ala Ser Thr Ala Leu Leu Ile 
1               5                   10                  15      
Ser Val Ala Phe Ser Ser Ser Ile Ala Ser Ala Val Glu Asp Ala Thr 
            20                  25                  30          
Arg Ser Asp Ser Thr Thr Gln Met Ser Ser Thr Pro Glu Val Val Tyr 
        35                  40                  45              
Ser Ser Ala Val Asp Ser Lys Gln Asn Arg Thr Ser Asp Phe Asp Ala 
    50                  55                  60                  
Asn Trp Lys Phe Met Leu Ser Asp Ser Val Gln Ala Gln Asp Pro Ala 
65                  70                  75                  80  
Phe Asp Asp Ser Ala Trp Gln Gln Val Asp Leu Pro His Asp Tyr Ser 
                85                  90                  95      
Ile Thr Gln Lys Tyr Ser Gln Ser Asn Glu Ala Glu Ser Ala Tyr Leu 
            100                 105                 110         
Pro Gly Gly Thr Gly Trp Tyr Arg Lys Ser Phe Thr Ile Asp Arg Asp 
        115                 120                 125             
Leu Ala Gly Lys Arg Ile Ala Ile Asn Phe Asp Gly Val Tyr Met Asn 
    130                 135                 140                 
Ala Thr Val Trp Phe Asn Gly Val Lys Leu Gly Thr His Pro Tyr Gly 
145                 150                 155                 160 
Tyr Ser Pro Phe Ser Phe Asp Leu Thr Gly Asn Ala Lys Phe Gly Gly 
                165                 170                 175     
Glu Asn Thr Ile Val Val Lys Val Glu Asn Arg Leu Pro Ser Ser Arg 
            180                 185                 190         
Trp Tyr Ser Gly Ser Gly Ile Tyr Arg Asp Val Thr Leu Thr Val Thr 
        195                 200                 205             
Asp Gly Val His Val Gly Asn Asn Gly Val Ala Ile Lys Thr Pro Ser 
    210                 215                 220                 
Leu Ala Thr Gln Asn Gly Gly Asn Val Thr Met Asn Leu Thr Thr Lys 
225                 230                 235                 240 
Val Ala Asn Asp Thr Lys Ala Ala Ala Asn Ile Thr Leu Lys Gln Thr 
                245                 250                 255     
Val Phe Pro Lys Gly Gly Lys Thr Asp Ala Ala Ile Gly Thr Val Thr 
            260                 265                 270         
Thr Ala Ser Lys Ser Ile Ala Ala Gly Ala Ser Ala Asp Val Thr Ser 
        275                 280                 285             
Thr Ile Thr Ala Ala Ser Pro Lys Leu Trp Ser Ile Lys Asn Pro Asn 
    290                 295                 300                 
Leu Tyr Thr Val Arg Thr Glu Val Leu Asn Gly Gly Lys Val Leu Asp 
305                 310                 315                 320 
Thr Tyr Asp Thr Glu Tyr Gly Phe Arg Trp Thr Gly Phe Asp Ala Thr 
                325                 330                 335     
Ser Gly Phe Ser Leu Asn Gly Glu Lys Val Lys Leu Lys Gly Val Ser 
            340                 345                 350         
Met His His Asp Gln Gly Ser Leu Gly Ala Val Ala Asn Arg Arg Ala 
        355                 360                 365             
Ile Glu Arg Gln Val Glu Ile Leu Gln Lys Met Gly Val Asn Ser Ile 
    370                 375                 380                 
Arg Thr Thr His Asn Pro Ala Ala Lys Ala Leu Ile Asp Val Cys Asn 
385                 390                 395                 400 
Glu Lys Gly Val Leu Val Val Glu Glu Val Phe Asp Met Trp Asn Arg 
                405                 410                 415     
Ser Lys Asn Gly Asn Thr Glu Asp Tyr Gly Lys Trp Phe Gly Gln Ala 
            420                 425                 430         
Ile Ala Gly Asp Asn Ala Val Leu Gly Gly Asp Lys Asp Glu Thr Trp 
        435                 440                 445             
Ala Lys Phe Asp Leu Thr Ser Thr Ile Asn Arg Asp Arg Asn Ala Pro 
    450                 455                 460                 
Ser Val Ile Met Trp Ser Leu Gly Asn Glu Met Met Glu Gly Ile Ser 
465                 470                 475                 480 
Gly Ser Val Ser Gly Phe Pro Ala Thr Ser Ala Lys Leu Val Ala Trp 
                485                 490                 495     
Thr Lys Ala Ala Asp Ser Thr Arg Pro Met Thr Tyr Gly Asp Asn Lys 
            500                 505                 510         
Ile Lys Ala Asn Trp Asn Glu Ser Asn Thr Met Gly Asp Asn Leu Thr 
        515                 520                 525             
Ala Asn Gly Gly Val Val Gly Thr Asn Tyr Ser Asp Gly Ala Asn Tyr 
    530                 535                 540                 
Asp Lys Ile Arg Thr Thr His Pro Ser Trp Ala Ile Tyr Gly Ser Glu 
545                 550                 555                 560 
Thr Ala Ser Ala Ile Asn Ser Arg Gly Ile Tyr Asn Arg Thr Thr Gly 
                565                 570                 575     
Gly Ala Gln Ser Ser Asp Lys Gln Leu Thr Ser Tyr Asp Asn Ser Ala 
            580                 585                 590         
Val Gly Trp Gly Ala Val Ala Ser Ser Ala Trp Tyr Asp Val Val Gln 
        595                 600                 605             
Arg Asp Phe Val Ala Gly Thr Tyr Val Trp Thr Gly Phe Asp Tyr Leu 
    610                 615                 620                 
Gly Glu Pro Thr Pro Trp Asn Gly Thr Gly Ser Gly Ala Val Gly Ser 
625                 630                 635                 640 
Trp Pro Ser Pro Lys Asn Ser Tyr Phe Gly Ile Val Asp Thr Ala Gly 
                645                 650                 655     
Phe Pro Lys Asp Thr Tyr Tyr Phe Tyr Gln Ser Gln Trp Asn Asp Asp 
            660                 665                 670         
Val His Thr Leu His Ile Leu Pro Ala Trp Asn Glu Asn Val Val Ala 
        675                 680                 685             
Lys Gly Ser Gly Asn Asn Val Pro Val Val Val Tyr Thr Asp Ala Ala 
    690                 695                 700                 
Lys Val Lys Leu Tyr Phe Thr Pro Lys Gly Ser Thr Glu Lys Arg Leu 
705                 710                 715                 720 
Ile Gly Glu Lys Ser Phe Thr Lys Lys Thr Thr Ala Ala Gly Tyr Thr 
                725                 730                 735     
Tyr Gln Val Tyr Glu Gly Ala Asp Lys Asp Ser Thr Ala His Lys Asn 
            740                 745                 750         
Met Tyr Leu Thr Trp Asn Val Pro Trp Ala Glu Gly Thr Ile Ser Ala 
        755                 760                 765             
Glu Ala Tyr Asp Glu Asn Asn Arg Leu Ile Pro Glu Gly Ser Thr Glu 
    770                 775                 780                 
Gly Asn Ala Ser Val Thr Thr Thr Gly Lys Ala Ala Lys Leu Lys Ala 
785                 790                 795                 800 
Asp Ala Asp Arg Lys Thr Ile Thr Ala Asp Gly Lys Asp Leu Ser Tyr 
                805                 810                 815     
Ile Glu Val Asp Val Thr Asp Ala Asn Gly His Ile Val Pro Asp Ala 
            820                 825                 830         
Ala Asn Arg Val Thr Phe Asp Val Lys Gly Ala Gly Lys Leu Val Gly 
        835                 840                 845             
Val Asp Asn Gly Ser Ser Pro Asp His Asp Ser Tyr Gln Ala Asp Asn 
    850                 855                 860                 
Arg Lys Ala Phe Ser Gly Lys Val Leu Ala Ile Val Gln Ser Thr Lys 
865                 870                 875                 880 
Glu Ala Gly Glu Ile Thr Val Thr Ala Lys Ala Asp Gly Leu Gln Ser 
                885                 890                 895     
Ser Thr Val Lys Ile Ala Thr Thr Ala Val Pro Gly Thr Ser Thr Glu 
            900                 905                 910         
Lys Thr Val Arg Ser Phe Tyr Tyr Ser Arg Asn Tyr Tyr Val Lys Thr 
        915                 920                 925             
Gly Asn Lys Pro Ile Leu Pro Ser Asp Val Glu Val Arg Tyr Ser Asp 
    930                 935                 940                 
Gly Thr Ser Asp Arg Gln Asn Val Thr Trp Asp Ala Val Ser Asp Asp 
945                 950                 955                 960 
Gln Ile Ala Lys Ala Gly Ser Phe Ser Val Ala Gly Thr Val Ala Gly 
                965                 970                 975     
Gln Lys Ile Ser Val Arg Val Thr Met Ile Asp Glu Ile Gly Ala Leu 
            980                 985                 990         
Leu Asn Tyr Ser Ala Ser Thr Pro Val Gly Thr Pro Ala Val Leu Pro 
        995                 1000                1005            
Gly Ser Arg Pro Ala Val Leu Pro Asp Gly Thr Val Thr Ser Ala Asn 
    1010                1015                1020                
Phe Ala Val Asp Trp Thr Lys Pro Ala Asp Thr Val Tyr Asn Thr Ala 
1025                1030                1035                1040
Gly Thr Val Lys Val Pro Gly Thr Ala Thr Val Phe Gly Lys Glu Phe 
                1045                1050                1055    
Lys Val Thr Ala Thr Ile Arg Val Gln Arg Ser Gln Val Thr Ile Gly 
            1060                1065                1070        
Ser Ser Val Ser Gly Asn Ala Leu Arg Leu Thr Gln Asn Ile Pro Ala 
        1075                1080                1085            
Asp Lys Gln Ser Asp Thr Leu Asp Ala Ile Lys Asp Gly Ser Thr Thr 
    1090                1095                1100                
Val Asp Ala Asn Thr Gly Gly Gly Ala Asn Pro Ser Ala Trp Thr Asn 
1105                1110                1115                1120
Trp Ala Tyr Ser Lys Ala Gly His Asn Thr Ala Glu Ile Thr Phe Glu 
                1125                1130                1135    
Tyr Ala Thr Glu Gln Gln Leu Gly Gln Ile Val Met Tyr Phe Phe Arg 
            1140                1145                1150        
Asp Ser Asn Ala Val Arg Phe Pro Asp Ala Gly Lys Thr Lys Ile Gln 
        1155                1160                1165            
Ile Ser Ala Asp Gly Lys Asn Trp Thr Asp Leu Ala Ala Thr Glu Thr 
    1170                1175                1180                
Ile Ala Ala Gln Glu Ser Ser Glu Arg Val Lys Pro Tyr Thr Tyr Asp 
1185                1190                1195                1200
Phe Ala Pro Val Gly Ala Thr Phe Val Lys Val Thr Val Thr Asn Ala 
                1205                1210                1215    
Asp Thr Thr Thr Pro Ser Gly Val Val Cys Ala Gly Leu Thr Glu Ile 
            1220                1225                1230        
Glu Leu Lys Thr Ala Thr Ser Lys Phe Val Thr Asn Thr Ser Ala Ala 
        1235                1240                1245            
Leu Ser Ser Leu Thr Val Asn Gly Thr Lys Val Ser Asp Ser Val Leu 
    1250                1255                1260                
Ala Ala Gly Ser Tyr Asn Thr Pro Ala Ile Ile Ala Asp Val Lys Ala 
1265                1270                1275                1280
Glu Gly Glu Gly Asn Ala Ser Val Thr Val Leu Pro Ala His Asp Asn 
                1285                1290                1295    
Val Ile Arg Val Ile Thr Glu Ser Glu Asp His Val Thr Arg Lys Thr 
            1300                1305                1310        
Phe Thr Ile Asn Leu Gly Thr Glu Gln Glu Phe Pro Ala Asp Ser Asp 
        1315                1320                1325            
Glu Arg Asp 
    1330    

