                         SEQUENCE LISTING

<110>  Board of Regents, the University of Texas System
 
<120>  ENGINEERED POLYPEPTIDES FOR ANTIGEN DELIVERY

<130>  UTFB.P1109WO

<140>  PCT/US17/23796
<141>  2017-03-23

<150>  62312021
<151>  2016-03-23

<160>  11    

<170>  PatentIn version 3.5

<210>  1
<211>  986
<212>  PRT
<213>  Yersinia pseudotuberculosis

<400>  1

Met Met Val Phe Gln Pro Ile Ser Glu Phe Leu Leu Ile Arg Asn Ala 
1               5                   10                  15      


Gly Met Ser Met Tyr Phe Asn Lys Ile Ile Ser Phe Asn Ile Ile Ser 
            20                  25                  30          


Arg Ile Val Ile Cys Ile Phe Leu Ile Cys Gly Met Phe Met Ala Gly 
        35                  40                  45              


Ala Ser Glu Lys Tyr Asp Ala Asn Ala Pro Gln Gln Val Gln Pro Tyr 
    50                  55                  60                  


Ser Val Ser Ser Ser Ala Phe Glu Asn Leu His Pro Asn Asn Glu Met 
65                  70                  75                  80  


Glu Ser Ser Ile Asn Pro Phe Ser Ala Ser Asp Thr Glu Arg Asn Ala 
                85                  90                  95      


Ala Ile Ile Asp Arg Ala Asn Lys Glu Gln Glu Thr Glu Ala Val Asn 
            100                 105                 110         


Lys Met Ile Ser Thr Gly Ala Arg Leu Ala Ala Ser Gly Arg Ala Ser 
        115                 120                 125             


Asp Val Ala His Ser Met Val Gly Asp Ala Val Asn Gln Glu Ile Lys 
    130                 135                 140                 


Gln Trp Leu Asn Arg Phe Gly Thr Ala Gln Val Asn Leu Asn Phe Asp 
145                 150                 155                 160 


Lys Asn Phe Ser Leu Lys Glu Ser Ser Leu Asp Trp Leu Ala Pro Trp 
                165                 170                 175     


Tyr Asp Ser Ala Ser Phe Leu Phe Phe Ser Gln Leu Gly Ile Arg Asn 
            180                 185                 190         


Lys Asp Ser Arg Asn Thr Leu Asn Leu Gly Val Gly Ile Arg Thr Leu 
        195                 200                 205             


Glu Asn Gly Trp Leu Tyr Gly Leu Asn Thr Phe Tyr Asp Asn Asp Leu 
    210                 215                 220                 


Thr Gly His Asn His Arg Ile Gly Leu Gly Ala Glu Ala Trp Thr Asp 
225                 230                 235                 240 


Tyr Leu Gln Leu Ala Ala Asn Gly Tyr Phe Arg Leu Asn Gly Trp His 
                245                 250                 255     


Ser Ser Arg Asp Phe Ser Asp Tyr Lys Glu Arg Pro Ala Thr Gly Gly 
            260                 265                 270         


Asp Leu Arg Ala Asn Ala Tyr Leu Pro Ala Leu Pro Gln Leu Gly Gly 
        275                 280                 285             


Lys Leu Met Tyr Glu Gln Tyr Thr Gly Glu Arg Val Ala Leu Phe Gly 
    290                 295                 300                 


Lys Asp Asn Leu Gln Arg Asn Pro Tyr Ala Val Thr Ala Gly Ile Asn 
305                 310                 315                 320 


Tyr Thr Pro Val Pro Leu Leu Thr Val Gly Val Asp Gln Arg Met Gly 
                325                 330                 335     


Lys Ser Ser Lys His Glu Thr Gln Trp Asn Leu Gln Met Asn Tyr Arg 
            340                 345                 350         


Leu Gly Glu Ser Phe Gln Ser Gln Leu Ser Pro Ser Ala Val Ala Gly 
        355                 360                 365             


Thr Arg Leu Leu Ala Glu Ser Arg Tyr Asn Leu Val Asp Arg Asn Asn 
    370                 375                 380                 


Asn Ile Val Leu Glu Tyr Gln Lys Gln Gln Val Val Lys Leu Thr Leu 
385                 390                 395                 400 


Ser Pro Ala Thr Ile Ser Gly Leu Pro Gly Gln Val Tyr Gln Val Asn 
                405                 410                 415     


Ala Gln Val Gln Gly Ala Ser Ala Val Arg Glu Ile Val Trp Ser Asp 
            420                 425                 430         


Ala Glu Leu Ile Ala Ala Gly Gly Thr Leu Thr Pro Leu Ser Thr Thr 
        435                 440                 445             


Gln Phe Asn Leu Val Leu Pro Pro Tyr Lys Arg Thr Ala Gln Val Ser 
    450                 455                 460                 


Arg Val Thr Asp Asp Leu Thr Ala Asn Phe Tyr Ser Leu Ser Ala Leu 
465                 470                 475                 480 


Ala Val Asp His Gln Gly Asn Arg Ser Asn Ser Phe Thr Leu Ser Val 
                485                 490                 495     


Thr Val Gln Gln Pro Gln Leu Thr Leu Thr Ala Ala Val Ile Gly Asp 
            500                 505                 510         


Gly Ala Pro Ala Asn Gly Lys Thr Ala Ile Thr Val Glu Phe Thr Val 
        515                 520                 525             


Ala Asp Phe Glu Gly Lys Pro Leu Ala Gly Gln Glu Val Val Ile Thr 
    530                 535                 540                 


Thr Asn Asn Gly Ala Leu Pro Asn Lys Ile Thr Glu Lys Thr Asp Ala 
545                 550                 555                 560 


Asn Gly Val Ala Arg Ile Ala Leu Thr Asn Thr Thr Asp Gly Val Thr 
                565                 570                 575     


Val Val Thr Ala Glu Val Glu Gly Gln Arg Gln Ser Val Asp Thr His 
            580                 585                 590         


Phe Val Lys Gly Thr Ile Ala Ala Asp Lys Ser Thr Leu Ala Ala Val 
        595                 600                 605             


Pro Thr Ser Ile Ile Ala Asp Gly Leu Met Ala Ser Thr Ile Thr Leu 
    610                 615                 620                 


Glu Leu Lys Asp Thr Tyr Gly Asp Pro Gln Ala Gly Ala Asn Val Ala 
625                 630                 635                 640 


Phe Asp Thr Thr Leu Gly Asn Met Gly Val Ile Thr Asp His Asn Asp 
                645                 650                 655     


Gly Thr Tyr Ser Ala Pro Leu Thr Ser Thr Thr Leu Gly Val Ala Thr 
            660                 665                 670         


Val Thr Val Lys Val Asp Gly Ala Ala Phe Ser Val Pro Ser Val Thr 
        675                 680                 685             


Val Asn Phe Thr Ala Asp Pro Ile Pro Asp Ala Gly Arg Ser Ser Phe 
    690                 695                 700                 


Thr Val Ser Thr Pro Asp Ile Leu Ala Asp Gly Thr Met Ser Ser Thr 
705                 710                 715                 720 


Leu Ser Phe Val Pro Val Asp Lys Asn Gly His Phe Ile Ser Gly Met 
                725                 730                 735     


Gln Gly Leu Ser Phe Thr Gln Asn Gly Val Pro Val Ser Ile Ser Pro 
            740                 745                 750         


Ile Thr Glu Gln Pro Asp Ser Tyr Thr Ala Thr Val Val Gly Asn Ser 
        755                 760                 765             


Val Gly Asp Val Thr Ile Thr Pro Gln Val Asp Thr Leu Ile Leu Ser 
    770                 775                 780                 


Thr Leu Gln Lys Lys Ile Ser Leu Phe Pro Val Pro Thr Leu Thr Gly 
785                 790                 795                 800 


Ile Leu Val Asn Gly Gln Asn Phe Ala Thr Asp Lys Gly Phe Pro Lys 
                805                 810                 815     


Thr Ile Phe Lys Asn Ala Thr Phe Gln Leu Gln Met Asp Asn Asp Val 
            820                 825                 830         


Ala Asn Asn Thr Gln Tyr Glu Trp Ser Ser Ser Phe Thr Pro Asn Val 
        835                 840                 845             


Ser Val Asn Asp Gln Gly Gln Val Thr Ile Thr Tyr Gln Thr Tyr Ser 
    850                 855                 860                 


Glu Val Ala Val Thr Ala Lys Ser Lys Lys Phe Pro Ser Tyr Ser Val 
865                 870                 875                 880 


Ser Tyr Arg Phe Tyr Pro Asn Arg Trp Ile Tyr Asp Gly Gly Arg Ser 
                885                 890                 895     


Leu Val Ser Ser Leu Glu Ala Ser Arg Gln Cys Gln Gly Ser Asp Met 
            900                 905                 910         


Ser Ala Val Leu Glu Ser Ser Arg Ala Thr Asn Gly Thr Arg Ala Pro 
        915                 920                 925             


Asp Gly Thr Leu Trp Gly Glu Trp Gly Ser Leu Thr Ala Tyr Ser Ser 
    930                 935                 940                 


Asp Trp Gln Ser Gly Glu Tyr Trp Val Lys Lys Thr Ser Thr Asp Phe 
945                 950                 955                 960 


Glu Thr Met Asn Met Asp Thr Gly Ala Leu Gln Pro Gly Pro Ala Tyr 
                965                 970                 975     


Leu Ala Phe Pro Leu Cys Ala Leu Ser Ile 
            980                 985     


<210>  2
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide (218 linker)

<400>  2

Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr 
1               5                   10                  15      


Lys Gly 
        


<210>  3
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide (HL linker)

<400>  3

Glu Ala Ala Ala Lys 
1               5   


<210>  4
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  4

Gly Gly Gly Gly Ser 
1               5   


<210>  5
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  5
agctatcgag ctcgaactca ttcacattga gcgtc                                  35


<210>  6
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  6
cgtcattata ccatggctag ttaatcatta tattgacagc gcacagag                    48


<210>  7
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  7
taactgacga tctagaactt taagaaggag atataccatg atggttttcc agcc             54


<210>  8
<211>  53
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  8
tacgatgtct aatgtatgca tgctcaatta ttcattatat tgacagcgca cag              53


<210>  9
<211>  742
<212>  PRT
<213>  Yersinia enterocolitica

<400>  9

Met Thr Ser Phe Phe Asn Thr Leu Thr Val Thr Lys Ile Ile Ser Arg 
1               5                   10                  15      


Leu Ile Leu Ser Ile Gly Leu Ile Phe Gly Ile Phe Thr Tyr Gly Phe 
            20                  25                  30          


Ser Gln Cys His Tyr Phe Asn Ser Glu Ala Leu Glu Asn Pro Ala Glu 
        35                  40                  45              


His Asn Gly Ala Gly Val Arg Thr Phe Gln Gln Ser Trp Met Tyr Gly 
    50                  55                  60                  


Phe Asn Thr Phe Tyr Asp Asn Asp Met Thr Gly His Asn His Arg Ile 
65                  70                  75                  80  


Gly Val Gly Ala Glu Ala Trp Thr Asp Tyr Leu Gln Leu Ser Ala Asn 
                85                  90                  95      


Gly Tyr Phe Arg Leu Asn Gly Trp His Gln Ser Arg Asp Phe Ala Asp 
            100                 105                 110         


Tyr Asn Glu Arg Pro Ala Ser Gly Gly Asp Ile His Val Lys Ala Tyr 
        115                 120                 125             


Leu Pro Ala Leu Pro Gln Leu Gly Gly Lys Leu Lys Tyr Glu Gln Tyr 
    130                 135                 140                 


Arg Gly Glu Arg Val Ala Leu Phe Gly Lys Asp Asn Leu Gln Ser Asn 
145                 150                 155                 160 


Pro Tyr Ala Val Thr Thr Gly Leu Ile Tyr Thr Pro Ile Pro Phe Ile 
                165                 170                 175     


Thr Leu Gly Val Asp Gln Arg Met Gly Lys Ser Arg Gln His Glu Ile 
            180                 185                 190         


Gln Trp Asn Leu Gln Met Asp Tyr Arg Leu Gly Glu Ser Phe Arg Ser 
        195                 200                 205             


Gln Phe Ser Pro Ala Val Val Ala Gly Thr Arg Leu Leu Ala Glu Ser 
    210                 215                 220                 


Arg Tyr Asn Leu Val Glu Arg Asn Pro Asn Ile Val Leu Glu Tyr Gln 
225                 230                 235                 240 


Lys Gln Asn Thr Ile Lys Leu Ala Phe Ser Pro Ala Val Leu Ser Gly 
                245                 250                 255     


Leu Pro Gly Gln Val Tyr Ser Val Ser Ala Gln Ile Gln Ser Gln Ala 
            260                 265                 270         


Leu Gln Arg Ile Leu Trp Asn Asp Ala Gln Trp Val Ala Ala Gly Gly 
        275                 280                 285             


Lys Leu Ile Pro Val Ser Ala Thr Asp Tyr Asn Val Val Leu Pro Pro 
    290                 295                 300                 


Tyr Lys Pro Met Ala Pro Ala Ser Arg Thr Val Gly Lys Thr Gly Glu 
305                 310                 315                 320 


Ser Glu Ala Ala Val Asn Thr Tyr Thr Leu Ser Ala Thr Ala Ile Asp 
                325                 330                 335     


Asn His Gly Asn Ser Ser Asn Pro Ala Thr Leu Thr Val Ile Val Gln 
            340                 345                 350         


Gln Pro Gln Phe Val Ile Thr Ser Glu Val Thr Asp Asp Gly Ala Leu 
        355                 360                 365             


Ala Asp Gly Arg Thr Pro Ile Thr Val Lys Phe Asn Thr Val Thr Asn 
    370                 375                 380                 


Ile Asp Ser Thr Pro Val Ala Glu Gln Glu Gly Val Ile Thr Thr Ser 
385                 390                 395                 400 


Asn Gly Ala Leu Pro Ser Lys Val Thr Lys Lys Thr Asp Ala Gln Gly 
                405                 410                 415     


Val Ile Ser Ile Ala Leu Thr Ser Phe Thr Val Gly Val Ser Val Val 
            420                 425                 430         


Thr Leu Asp Ile Gln Gly Gln Gln Ala Thr Val Asp Val Arg Phe Ala 
        435                 440                 445             


Val Leu Pro Pro Asp Val Thr Asn Ser Ser Phe Asn Val Ser Pro Ser 
    450                 455                 460                 


Asp Ile Val Ala Asp Gly Ser Met Gln Ser Ile Leu Thr Phe Val Pro 
465                 470                 475                 480 


Arg Asn Lys Asn Asn Glu Phe Val Ser Gly Ile Thr Asp Leu Glu Phe 
                485                 490                 495     


Ile Gln Ser Gly Val Pro Val Thr Ile Ser Ser Val Thr Glu Asn Ala 
            500                 505                 510         


Asp Asn Tyr Thr Ala Ser Val Val Gly Asn Ser Val Gly Asp Val Asp 
        515                 520                 525             


Ile Thr Thr Gln Val Gly Gly Glu Ser Leu Asp Leu Leu Gln Lys Arg 
    530                 535                 540                 


Ile Thr Leu Tyr Pro Val Pro Ile Thr Gly Ile Lys Val Asn Gly Glu 
545                 550                 555                 560 


Gln Phe Ala Thr Asp Lys Gly Phe Pro Lys Thr Thr Phe Asn Lys Ala 
                565                 570                 575     


Thr Phe Gln Leu Val Met Asn Asp Asp Val Ala Asn Asn Thr Gln Tyr 
            580                 585                 590         


Asp Trp Thr Ser Ser Tyr Ala Ala Ser Ala Pro Val Asp Asn Gln Gly 
        595                 600                 605             


Lys Val Asn Ile Ala Tyr Lys Thr Tyr Gly Ser Thr Val Thr Val Thr 
    610                 615                 620                 


Ala Lys Ser Lys Lys Phe Pro Ser Tyr Thr Ala Thr Tyr Gln Phe Lys 
625                 630                 635                 640 


Pro Asn Leu Trp Val Phe Ser Gly Thr Met Ser Ser Leu Gln Ser Ser 
                645                 650                 655     


Val Glu Ala Ser Arg Asn Cys Gln Arg Thr Asp Phe Thr Ala Leu Ile 
            660                 665                 670         


Glu Ser Ala Arg Ala Ser Asn Gly Ser Arg Ser Pro Asp Gly Thr Leu 
        675                 680                 685             


Trp Gly Glu Trp Gly Ser Leu Ala Thr Tyr Asp Ser Ala Glu Trp Pro 
    690                 695                 700                 


Ser Gly Asn Tyr Trp Thr Lys Lys Thr Ser Thr Asp Phe Val Thr Asn 
705                 710                 715                 720 


Asp Met Thr Thr Gly Asp Ile Pro Thr Ser Ala Ala Thr Ala Tyr Pro 
                725                 730                 735     


Leu Cys Ala Glu Pro Gln 
            740         


<210>  10
<211>  785
<212>  PRT
<213>  Yersinia pseudotuberculosis

<400>  10

Met Val Phe Gln Pro Ile Ser Glu Phe Leu Leu Ile Arg Asn Ala Gly 
1               5                   10                  15      


Met Ser Met Tyr Phe Asn Lys Ile Ile Ser Phe Asn Ile Ile Ser Arg 
            20                  25                  30          


Ile Val Ile Cys Ile Phe Leu Ile Cys Gly Met Phe Met Ala Gly Ala 
        35                  40                  45              


Ser Glu Lys Tyr Asp Ala Asn Ala Pro Gln Gln Val Gln Pro Tyr Ser 
    50                  55                  60                  


Val Ser Ser Ser Ala Phe Glu Asn Leu His Pro Asn Asn Glu Met Glu 
65                  70                  75                  80  


Ser Ser Ile Asn Pro Phe Ser Ala Ser Asp Thr Glu Arg Asn Ala Ala 
                85                  90                  95      


Ile Ile Asp Arg Gly Val Gly Ile Arg Thr Leu Glu Asn Gly Trp Leu 
            100                 105                 110         


Tyr Gly Leu Asn Thr Phe Tyr Asp Asn Asp Leu Thr Gly His Asn His 
        115                 120                 125             


Arg Ile Gly Leu Gly Ala Glu Ala Trp Thr Asp Tyr Leu Gln Leu Ala 
    130                 135                 140                 


Ala Asn Gly Tyr Phe Arg Leu Asn Gly Trp His Ser Ser Arg Asp Phe 
145                 150                 155                 160 


Ser Asp Tyr Lys Glu Arg Pro Ala Thr Gly Gly Asp Leu Arg Ala Asn 
                165                 170                 175     


Ala Tyr Leu Pro Ala Leu Pro Gln Leu Gly Gly Lys Leu Met Tyr Glu 
            180                 185                 190         


Gln Tyr Thr Gly Glu Arg Val Ala Pro Ala Thr Ile Ser Gly Leu Pro 
        195                 200                 205             


Gly Gln Val Thr Gln Asn Val Ala Gln Val Gln Gly Ala Ser Ala Val 
    210                 215                 220                 


Arg Glu Ile Val Trp Ser Asp Ala Glu Leu Ile Ala Ala Gly Gly Thr 
225                 230                 235                 240 


Leu Thr Pro Leu Ser Thr Thr Gln Phe Asn Leu Val Leu Pro Pro Tyr 
                245                 250                 255     


Lys Arg Thr Ala Gln Val Ser Arg Val Thr Asp Asp Leu Thr Ala Asn 
            260                 265                 270         


Phe Tyr Ser Leu Ser Ala Leu Ala Val Asp His Gln Gly Asn Arg Ser 
        275                 280                 285             


Asn Ser Phe Thr Leu Ser Val Thr Val Gln Gln Pro Gln Leu Thr Leu 
    290                 295                 300                 


Thr Ala Ala Val Ile Gly Asp Gly Ala Pro Ala Asn Gly Lys Thr Ala 
305                 310                 315                 320 


Ile Thr Val Glu Phe Thr Val Ala Asp Phe Glu Gly Lys Pro Leu Ala 
                325                 330                 335     


Gly Gln Glu Val Val Ile Thr Thr Asn Asn Gly Ala Leu Pro Asn Lys 
            340                 345                 350         


Ile Thr Glu Lys Thr Asp Ala Asn Gly Val Ala Arg Ile Ala Leu Thr 
        355                 360                 365             


Asn Thr Thr Asp Gly Val Thr Val Val Thr Ala Glu Val Glu Gly Gln 
    370                 375                 380                 


Arg Gln Ser Val Asp Thr His Phe Val Lys Gly Thr Ile Ala Ala Asp 
385                 390                 395                 400 


Lys Ser Thr Leu Ala Ala Val Pro Thr Ser Ile Ile Ala Asp Gly Leu 
                405                 410                 415     


Met Ala Ser Thr Ile Thr Leu Glu Leu Lys Asp Thr Tyr Gly Asp Pro 
            420                 425                 430         


Gln Ala Gly Ala Asn Val Ala Phe Asp Thr Thr Leu Gly Asn Met Gly 
        435                 440                 445             


Val Ile Thr Asp His Asn Asp Gly Thr Tyr Ser Ala Pro Leu Thr Ser 
    450                 455                 460                 


Thr Thr Leu Gly Val Ala Thr Val Thr Val Lys Val Asp Gly Ala Ala 
465                 470                 475                 480 


Phe Ser Val Pro Ser Val Thr Val Asn Phe Thr Ala Asp Pro Ile Pro 
                485                 490                 495     


Asp Ala Gly Arg Ser Ser Phe Thr Val Ser Thr Pro Asp Ile Leu Ala 
            500                 505                 510         


Asp Gly Thr Asn Ser Ser Thr Leu Ser Phe Val Pro Val Asp Lys Asn 
        515                 520                 525             


Gly His Phe Ile Ser Gly Met Gln Gly Leu Ser Phe Thr Gln Asn Gly 
    530                 535                 540                 


Val Pro Val Ser Ile Ser Pro Ile Thr Glu Gln Pro Asp Ser Tyr Thr 
545                 550                 555                 560 


Ala Thr Val Val Gly Asn Thr Ala Gly Asp Val Thr Ile Thr Pro Gln 
                565                 570                 575     


Val Asp Thr Leu Ile Leu Ser Thr Leu Gln Lys Lys Ile Ser Leu Phe 
            580                 585                 590         


Pro Val Pro Leu Thr Phe Ile Leu Val Asn Gly Gln Asn Phe Ala Thr 
        595                 600                 605             


Asp Lys Gly Phe Pro Lys Thr Ile Phe Lys Asn Ala Thr Phe Gln Leu 
    610                 615                 620                 


Gln Met Asp Asn Asp Val Ala Asn Asn Thr Gln Tyr Glu Trp Ser Ser 
625                 630                 635                 640 


Ser Phe Thr Pro Asn Val Ser Val Asn Asp Gln Gly Gln Val Thr Ile 
                645                 650                 655     


Thr Tyr Gln Thr Tyr Ser Glu Val Ala Val Thr Ala Lys Ser Lys Lys 
            660                 665                 670         


Phe Pro Ser Tyr Ser Val Ser Tyr Arg Phe Tyr Pro Asn Arg Trp Ile 
        675                 680                 685             


Tyr Asp Gly Gly Thr Ser Ser Leu Val Ser Ser Leu Glu Ala Ser Arg 
    690                 695                 700                 


Gln Cys Gln Gly Ser Asp Met Ser Ala Val Leu Glu Ser Ser Arg Ala 
705                 710                 715                 720 


Thr Asn Gly Thr Arg Ala Pro Asp Gly Thr Leu Trp Gly Glu Trp Gly 
                725                 730                 735     


Ser Leu Thr Ala Tyr Ser Ser Asp Trp Gln Ser Gly Glu Tyr Trp Val 
            740                 745                 750         


Lys Lys Thr Ser Thr Asp Phe Glu Thr Met Asn Met Asp Thr Gly Ala 
        755                 760                 765             


Leu Val Gln Gly Pro Ala Tyr Leu Ala Phe Pro Leu Cys Ala Leu Ala 
    770                 775                 780                 


Ile 
785 


<210>  11
<211>  542
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  11

Met Phe Phe Asn Ile Ile Ile Ser Arg Ile Ile Ile Ile Leu Ile Gly 
1               5                   10                  15      


Ile Phe Gly Ser His Asn Ala Ala Glu Asn Asn Gly Gly Ile Arg Thr 
            20                  25                  30          


Asn Trp Leu Tyr Gly Asn Thr Phe Tyr Asp Asn Asp Leu Thr Gly His 
        35                  40                  45              


Asn His Arg Ile Gly Leu Gly Ala Glu Ala Trp Thr Asp Tyr Leu Gln 
    50                  55                  60                  


Leu Ala Ala Asn Gly Tyr Phe Arg Leu Asn Gly Trp His Ser Arg Asp 
65                  70                  75                  80  


Phe Ala Asp Tyr Glu Arg Pro Ala Ser Gly Gly Asp Ile Ala Tyr Leu 
                85                  90                  95      


Pro Ala Leu Pro Gln Leu Gly Gly Lys Leu Tyr Glu Gln Tyr Gly Glu 
            100                 105                 110         


Arg Val Ala Leu Phe Gly Lys Asp Asn Leu Gln Asn Pro Tyr Ala Val 
        115                 120                 125             


Thr Gly Ile Tyr Thr Pro Ile Pro Ile Thr Leu Gly Val Asp Gln Arg 
    130                 135                 140                 


Met Gly Lys Ser His Glu Gln Trp Asn Leu Gln Met Tyr Arg Leu Gly 
145                 150                 155                 160 


Glu Ser Phe Ser Gln Ser Pro Ala Val Ala Gly Thr Arg Leu Leu Ala 
                165                 170                 175     


Glu Ser Arg Tyr Asn Leu Val Asp Arg Asn Asn Ile Val Leu Glu Tyr 
            180                 185                 190         


Gln Lys Gln Asn Ile Lys Leu Ser Pro Ala Ile Ser Gly Leu Pro Gly 
        195                 200                 205             


Gln Val Tyr Val Ala Gln Ile Gln Ser Ala Leu Ile Leu Trp Asp Ala 
    210                 215                 220                 


Ile Ala Ala Gly Gly Leu Pro Leu Ser Thr Phe Asn Leu Val Leu Pro 
225                 230                 235                 240 


Pro Tyr Lys Ala Ser Arg Asp Asn Tyr Ser Leu Ser Ala Ala Ile Asp 
                245                 250                 255     


Gly Asn Ser Asn Thr Leu Ser Val Val Gln Gln Pro Gln Ile Thr Ala 
            260                 265                 270         


Val Asp Gly Ala Ala Gly Lys Thr Ile Thr Val Phe Thr Val Asp Pro 
        275                 280                 285             


Leu Ala Gln Glu Val Ile Thr Thr Asn Gly Ala Leu Pro Lys Ile Thr 
    290                 295                 300                 


Lys Thr Asp Ala Asn Gly Val Ile Ala Leu Thr Thr Gly Val Ser Val 
305                 310                 315                 320 


Val Thr Asp Ile Gly Gln Gln Ala Val Phe Pro Asp Ser Ser Phe Val 
                325                 330                 335     


Ser Asp Ile Leu Ala Asp Gly Ser Met Ser Leu Ser Phe Val Pro Lys 
            340                 345                 350         


Asn Phe Ile Ser Gln Ile Leu Phe Gln Gly Val Pro Val Ser Ile Ser 
        355                 360                 365             


Ile Thr Glu Asn Asp Tyr Thr Ala Ser Val Val Gly Asn Ser Gly Asp 
    370                 375                 380                 


Val Ile Thr Pro Gln Val Leu Leu Gln Lys Lys Ile Ser Leu Phe Pro 
385                 390                 395                 400 


Val Pro Ile Thr Gly Ile Val Asn Gly Asn Phe Ala Thr Asp Lys Gly 
                405                 410                 415     


Phe Pro Lys Thr Phe Ala Thr Phe Gln Leu Met Asp Val Ala Asn Asn 
            420                 425                 430         


Thr Gln Tyr Asp Trp Ser Ser Ser Phe Val Gln Gly Val Ile Tyr Thr 
        435                 440                 445             


Tyr Ser Val Val Thr Ala Lys Ser Lys Lys Phe Pro Ser Tyr Ser Ser 
    450                 455                 460                 


Tyr Phe Pro Asn Trp Ile Phe Gly Ser Ser Leu Ser Ser Leu Glu Ala 
465                 470                 475                 480 


Ser Arg Asn Cys Gln Ser Asp Ser Ala Leu Ile Glu Ser Ala Arg Ala 
                485                 490                 495     


Ser Asn Gly Ser Arg Ala Pro Asp Gly Thr Leu Trp Gly Glu Trp Gly 
            500                 505                 510         


Ser Leu Tyr Ala Asp Trp Ser Gly Tyr Trp Lys Lys Thr Ser Thr Asp 
        515                 520                 525             


Phe Thr Met Met Thr Gly Ile Ala Ala Phe Pro Leu Cys Ala 
    530                 535                 540         


