                         SEQUENCE LISTING

<110>  Yale University
       Simons, Michael
       Chen, Pei-Yu
 
<120>  METHODS AND COMPOSITIONS FOR TREATING ATHEROSCLEROSIS

<130>  047162-7080WO1(00535)

<150>  62/311,086
<151>  2016-03-21

<150>  62/406,732
<151>  2016-10-11

<160>  38    

<170>  PatentIn version 3.5

<210>  1
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  1
gagtgtgctg tgattggaag gcag                                              24


<210>  2
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  2
ggcacgagtg tctgcagaca catg                                              24


<210>  3
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  3
gtctggcagt aaaaactatc                                                   20


<210>  4
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  4
gtgaaacagc attgctgtca ctt                                               23


<210>  5
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  5
ctaggccaca gaattgaaag atct                                              24


<210>  6
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  6
gtaggtggaa attctagcat catcc                                             25


<210>  7
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  7
gcctagccga gggagagccg                                                   20


<210>  8
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  8
gtgacttggg agctctgcag c                                                 21


<210>  9
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  9
gccgccccga ctgcatct                                                     18


<210>  10
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  10
gcctgcatta ccggtcgatg caacga                                            26


<210>  11
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  11
gtggcagatg gcgcggcaac accatt                                            26


<210>  12
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  12
actcacatgt tggctctcac tgtc                                              24


<210>  13
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  13
agtcatagag catgtgttag agtc                                              24


<210>  14
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  14
taaacaaggt ccggagccca                                                   20


<210>  15
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  15
acttctgcaa gaggtcccct                                                   20


<210>  16
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  16
ctctgctgcc tcctggcttc t                                                 21


<210>  17
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  17
cgaggcggat cacaagcaat a                                                 21


<210>  18
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  18
tcaatgggcg ggggtcgtt                                                    19


<210>  19
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  19
ugagguagua gguugugugg uu                                                22


<210>  20
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  20
cuauacaacc uacugccuuc cc                                                22


<210>  21
<211>  820
<212>  PRT
<213>  homo sapiens

<400>  21

Met Trp Ser Trp Lys Cys Leu Leu Phe Trp Ala Val Leu Val Thr Ala 
1               5                   10                  15      


Thr Leu Cys Thr Ala Arg Pro Ser Pro Thr Leu Pro Glu Gln Ala Gln 
            20                  25                  30          


Pro Trp Gly Ala Pro Val Glu Val Glu Ser Phe Leu Val His Pro Gly 
        35                  40                  45              


Asp Leu Leu Gln Leu Arg Cys Arg Leu Arg Asp Asp Val Gln Ser Ile 
    50                  55                  60                  


Asn Trp Leu Arg Asp Gly Val Gln Leu Ala Glu Ser Asn Arg Thr Arg 
65                  70                  75                  80  


Ile Thr Gly Glu Glu Val Glu Val Gln Asp Ser Val Pro Ala Asp Ser 
                85                  90                  95      


Gly Leu Tyr Ala Cys Val Thr Ser Ser Pro Ser Gly Ser Asp Thr Thr 
            100                 105                 110         


Tyr Phe Ser Val Asn Val Ser Asp Ala Leu Pro Ser Ser Glu Asp Asp 
        115                 120                 125             


Asp Asp Asp Asp Asp Ser Ser Ser Glu Glu Lys Glu Thr Asp Asn Thr 
    130                 135                 140                 


Lys Pro Asn Arg Met Pro Val Ala Pro Tyr Trp Thr Ser Pro Glu Lys 
145                 150                 155                 160 


Met Glu Lys Lys Leu His Ala Val Pro Ala Ala Lys Thr Val Lys Phe 
                165                 170                 175     


Lys Cys Pro Ser Ser Gly Thr Pro Asn Pro Thr Leu Arg Trp Leu Lys 
            180                 185                 190         


Asn Gly Lys Glu Phe Lys Pro Asp His Arg Ile Gly Gly Tyr Lys Val 
        195                 200                 205             


Arg Tyr Ala Thr Trp Ser Ile Ile Met Asp Ser Val Val Pro Ser Asp 
    210                 215                 220                 


Lys Gly Asn Tyr Thr Cys Ile Val Glu Asn Glu Tyr Gly Ser Ile Asn 
225                 230                 235                 240 


His Thr Tyr Gln Leu Asp Val Val Glu Arg Ser Pro His Arg Pro Ile 
                245                 250                 255     


Leu Gln Ala Gly Leu Pro Ala Asn Lys Thr Val Ala Leu Gly Ser Asn 
            260                 265                 270         


Val Glu Phe Met Cys Lys Val Tyr Ser Asp Pro Gln Pro His Ile Gln 
        275                 280                 285             


Trp Leu Lys His Ile Glu Val Asn Gly Ser Lys Ile Gly Pro Asp Asn 
    290                 295                 300                 


Leu Pro Tyr Val Gln Ile Leu Lys Thr Ala Gly Val Asn Thr Thr Asp 
305                 310                 315                 320 


Lys Glu Met Glu Val Leu His Leu Arg Asn Val Ser Phe Glu Asp Ala 
                325                 330                 335     


Gly Glu Tyr Thr Cys Leu Ala Gly Asn Ser Ile Gly Leu Ser His His 
            340                 345                 350         


Ser Ala Trp Leu Thr Val Leu Glu Ala Leu Glu Glu Arg Pro Ala Val 
        355                 360                 365             


Met Thr Ser Pro Leu Tyr Leu Glu Ile Ile Ile Tyr Cys Thr Gly Ala 
    370                 375                 380                 


Phe Leu Ile Ser Cys Met Val Gly Ser Val Ile Val Tyr Lys Met Lys 
385                 390                 395                 400 


Ser Gly Thr Lys Lys Ser Asp Phe His Ser Gln Met Ala Val His Lys 
                405                 410                 415     


Leu Ala Lys Ser Ile Pro Leu Arg Arg Gln Val Ser Ala Asp Ser Ser 
            420                 425                 430         


Ala Ser Met Asn Ser Gly Val Leu Leu Val Arg Pro Ser Arg Leu Ser 
        435                 440                 445             


Ser Ser Gly Thr Pro Met Leu Ala Gly Val Ser Glu Tyr Glu Leu Pro 
    450                 455                 460                 


Glu Asp Pro Arg Trp Glu Leu Pro Arg Asp Arg Leu Val Leu Gly Lys 
465                 470                 475                 480 


Pro Leu Gly Glu Gly Cys Phe Gly Gln Val Val Leu Ala Glu Ala Ile 
                485                 490                 495     


Gly Leu Asp Lys Asp Lys Pro Asn Arg Val Thr Lys Val Ala Val Lys 
            500                 505                 510         


Met Leu Lys Ser Asp Ala Thr Glu Lys Asp Leu Ser Asp Leu Ile Ser 
        515                 520                 525             


Glu Met Glu Met Met Lys Met Ile Gly Lys His Lys Asn Ile Ile Asn 
    530                 535                 540                 


Leu Leu Gly Ala Cys Thr Gln Asp Gly Pro Leu Tyr Val Ile Val Glu 
545                 550                 555                 560 


Tyr Ala Ser Lys Gly Asn Leu Arg Glu Tyr Leu Gln Ala Arg Arg Pro 
                565                 570                 575     


Pro Gly Leu Glu Tyr Cys Tyr Asn Pro Ser His Asn Pro Glu Glu Gln 
            580                 585                 590         


Leu Ser Ser Lys Asp Leu Val Ser Cys Ala Tyr Gln Val Ala Arg Gly 
        595                 600                 605             


Met Glu Tyr Leu Ala Ser Lys Lys Cys Ile His Arg Asp Leu Ala Ala 
    610                 615                 620                 


Arg Asn Val Leu Val Thr Glu Asp Asn Val Met Lys Ile Ala Asp Phe 
625                 630                 635                 640 


Gly Leu Ala Arg Asp Ile His His Ile Asp Tyr Tyr Lys Lys Thr Thr 
                645                 650                 655     


Asn Gly Arg Leu Pro Val Lys Trp Met Ala Pro Glu Ala Leu Phe Asp 
            660                 665                 670         


Arg Ile Tyr Thr His Gln Ser Asp Val Trp Ser Phe Gly Val Leu Leu 
        675                 680                 685             


Trp Glu Ile Phe Thr Leu Gly Gly Ser Pro Tyr Pro Gly Val Pro Val 
    690                 695                 700                 


Glu Glu Leu Phe Lys Leu Leu Lys Glu Gly His Arg Met Asp Lys Pro 
705                 710                 715                 720 


Ser Asn Cys Thr Asn Glu Leu Tyr Met Met Met Arg Asp Cys Trp His 
                725                 730                 735     


Ala Val Pro Ser Gln Arg Pro Thr Phe Lys Gln Leu Val Glu Asp Leu 
            740                 745                 750         


Asp Arg Ile Val Ala Leu Thr Ser Asn Gln Glu Tyr Leu Asp Leu Ser 
        755                 760                 765             


Met Pro Leu Asp Gln Tyr Ser Pro Ser Phe Pro Asp Thr Arg Ser Ser 
    770                 775                 780                 


Thr Cys Ser Ser Gly Glu Asp Ser Val Phe Ser His Glu Pro Leu Pro 
785                 790                 795                 800 


Glu Glu Pro Cys Leu Pro Arg His Pro Ala Gln Leu Ala Asn Gly Gly 
                805                 810                 815     


Leu Lys Arg Arg 
            820 


<210>  22
<211>  3913
<212>  PRT
<213>  homo sapiens

<400>  22

Ala Gly Cys Gly Cys Thr Cys Thr Thr Gly Cys Gly Gly Cys Cys Ala 
1               5                   10                  15      


Cys Ala Gly Gly Cys Gly Cys Gly Gly Cys Gly Thr Cys Cys Thr Cys 
            20                  25                  30          


Gly Gly Cys Gly Gly Cys Gly Gly Gly Cys Gly Gly Cys Ala Gly Cys 
        35                  40                  45              


Thr Ala Gly Cys Gly Gly Gly Ala Gly Cys Cys Gly Gly Gly Ala Cys 
    50                  55                  60                  


Gly Cys Cys Gly Gly Thr Gly Cys Ala Gly Cys Cys Gly Cys Ala Gly 
65                  70                  75                  80  


Cys Gly Cys Gly Cys Gly Gly Ala Gly Gly Ala Ala Cys Cys Cys Gly 
                85                  90                  95      


Gly Gly Thr Gly Thr Gly Cys Cys Gly Gly Gly Ala Gly Cys Thr Gly 
            100                 105                 110         


Gly Gly Cys Gly Gly Cys Cys Ala Cys Gly Thr Cys Cys Gly Gly Ala 
        115                 120                 125             


Cys Gly Gly Gly Ala Cys Cys Gly Ala Gly Ala Cys Cys Cys Cys Thr 
    130                 135                 140                 


Cys Gly Thr Ala Gly Cys Gly Cys Ala Thr Thr Gly Cys Gly Gly Cys 
145                 150                 155                 160 


Gly Ala Cys Cys Thr Cys Gly Cys Cys Thr Thr Cys Cys Cys Cys Gly 
                165                 170                 175     


Gly Cys Cys Gly Cys Gly Ala Gly Cys Gly Cys Gly Cys Cys Gly Cys 
            180                 185                 190         


Thr Gly Cys Thr Thr Gly Ala Ala Ala Ala Gly Cys Cys Gly Cys Gly 
        195                 200                 205             


Gly Ala Ala Cys Cys Cys Ala Ala Gly Gly Ala Cys Thr Thr Thr Thr 
    210                 215                 220                 


Cys Thr Cys Cys Gly Gly Thr Cys Cys Gly Ala Gly Cys Thr Cys Gly 
225                 230                 235                 240 


Gly Gly Gly Cys Gly Cys Cys Cys Cys Gly Cys Ala Gly Gly Gly Cys 
                245                 250                 255     


Gly Cys Ala Cys Gly Gly Thr Ala Cys Cys Cys Gly Thr Gly Cys Thr 
            260                 265                 270         


Gly Cys Ala Gly Thr Cys Gly Gly Gly Cys Ala Cys Gly Cys Cys Gly 
        275                 280                 285             


Cys Gly Gly Cys Gly Cys Cys Gly Gly Gly Gly Cys Cys Thr Cys Cys 
    290                 295                 300                 


Gly Cys Ala Gly Gly Gly Cys Gly Ala Thr Gly Gly Ala Gly Cys Cys 
305                 310                 315                 320 


Cys Gly Gly Thr Cys Thr Gly Cys Ala Ala Gly Gly Ala Ala Ala Gly 
                325                 330                 335     


Thr Gly Ala Gly Gly Cys Gly Cys Cys Gly Cys Cys Gly Cys Thr Gly 
            340                 345                 350         


Cys Gly Thr Thr Cys Thr Gly Gly Ala Gly Gly Ala Gly Gly Gly Gly 
        355                 360                 365             


Gly Gly Cys Ala Cys Cys Ala Gly Cys Thr Cys Cys Gly Gly Cys Thr 
    370                 375                 380                 


Cys Cys Ala Thr Thr Gly Thr Thr Cys Cys Cys Gly Cys Cys Cys Gly 
385                 390                 395                 400 


Gly Gly Cys Thr Gly Gly Ala Gly Gly Cys Gly Cys Cys Gly Ala Gly 
                405                 410                 415     


Cys Ala Cys Cys Gly Ala Gly Cys Gly Cys Cys Gly Cys Cys Gly Gly 
            420                 425                 430         


Gly Ala Gly Thr Cys Gly Ala Gly Cys Gly Cys Cys Gly Gly Cys Cys 
        435                 440                 445             


Gly Cys Gly Gly Ala Gly Cys Thr Cys Thr Thr Gly Cys Gly Ala Cys 
    450                 455                 460                 


Cys Cys Cys Gly Cys Cys Ala Gly Gly Ala Cys Cys Cys Gly Ala Ala 
465                 470                 475                 480 


Cys Ala Gly Ala Gly Cys Cys Cys Gly Gly Gly Gly Gly Cys Gly Gly 
                485                 490                 495     


Cys Gly Gly Gly Cys Cys Gly Gly Ala Gly Cys Cys Gly Gly Gly Gly 
            500                 505                 510         


Ala Cys Gly Cys Gly Gly Gly Cys Ala Cys Ala Cys Gly Cys Cys Cys 
        515                 520                 525             


Gly Cys Thr Cys Gly Cys Ala Cys Ala Ala Gly Cys Cys Ala Cys Gly 
    530                 535                 540                 


Gly Cys Gly Gly Ala Cys Thr Cys Thr Cys Cys Cys Gly Ala Gly Gly 
545                 550                 555                 560 


Cys Gly Gly Ala Ala Cys Cys Thr Cys Cys Ala Cys Gly Cys Cys Gly 
                565                 570                 575     


Ala Gly Cys Gly Ala Gly Gly Gly Thr Cys Ala Gly Thr Thr Thr Gly 
            580                 585                 590         


Ala Ala Ala Ala Gly Gly Ala Gly Gly Ala Thr Cys Gly Ala Gly Cys 
        595                 600                 605             


Thr Cys Ala Cys Thr Gly Thr Gly Gly Ala Gly Thr Ala Thr Cys Cys 
    610                 615                 620                 


Ala Thr Gly Gly Ala Gly Ala Thr Gly Thr Gly Gly Ala Gly Cys Cys 
625                 630                 635                 640 


Thr Thr Gly Thr Cys Ala Cys Cys Ala Ala Cys Cys Thr Cys Thr Ala 
                645                 650                 655     


Ala Cys Thr Gly Cys Ala Gly Ala Ala Cys Thr Gly Gly Gly Ala Thr 
            660                 665                 670         


Gly Thr Gly Gly Ala Gly Cys Thr Gly Gly Ala Ala Gly Thr Gly Cys 
        675                 680                 685             


Cys Thr Cys Cys Thr Cys Thr Thr Cys Thr Gly Gly Gly Cys Thr Gly 
    690                 695                 700                 


Thr Gly Cys Thr Gly Gly Thr Cys Ala Cys Ala Gly Cys Cys Ala Cys 
705                 710                 715                 720 


Ala Cys Thr Cys Thr Gly Cys Ala Cys Cys Gly Cys Thr Ala Gly Gly 
                725                 730                 735     


Cys Cys Gly Thr Cys Cys Cys Cys Gly Ala Cys Cys Thr Thr Gly Cys 
            740                 745                 750         


Cys Thr Gly Ala Ala Cys Ala Ala Gly Cys Cys Cys Ala Gly Cys Cys 
        755                 760                 765             


Cys Thr Gly Gly Gly Gly Ala Gly Cys Cys Cys Cys Thr Gly Thr Gly 
    770                 775                 780                 


Gly Ala Ala Gly Thr Gly Gly Ala Gly Thr Cys Cys Thr Thr Cys Cys 
785                 790                 795                 800 


Thr Gly Gly Thr Cys Cys Ala Cys Cys Cys Cys Gly Gly Thr Gly Ala 
                805                 810                 815     


Cys Cys Thr Gly Cys Thr Gly Cys Ala Gly Cys Thr Thr Cys Gly Cys 
            820                 825                 830         


Thr Gly Thr Cys Gly Gly Cys Thr Gly Cys Gly Gly Gly Ala Cys Gly 
        835                 840                 845             


Ala Thr Gly Thr Gly Cys Ala Gly Ala Gly Cys Ala Thr Cys Ala Ala 
    850                 855                 860                 


Cys Thr Gly Gly Cys Thr Gly Cys Gly Gly Gly Ala Cys Gly Gly Gly 
865                 870                 875                 880 


Gly Thr Gly Cys Ala Gly Cys Thr Gly Gly Cys Gly Gly Ala Ala Ala 
                885                 890                 895     


Gly Cys Ala Ala Cys Cys Gly Cys Ala Cys Cys Cys Gly Cys Ala Thr 
            900                 905                 910         


Cys Ala Cys Ala Gly Gly Gly Gly Ala Gly Gly Ala Gly Gly Thr Gly 
        915                 920                 925             


Gly Ala Gly Gly Thr Gly Cys Ala Gly Gly Ala Cys Thr Cys Cys Gly 
    930                 935                 940                 


Thr Gly Cys Cys Cys Gly Cys Ala Gly Ala Cys Thr Cys Cys Gly Gly 
945                 950                 955                 960 


Cys Cys Thr Cys Thr Ala Thr Gly Cys Thr Thr Gly Cys Gly Thr Ala 
                965                 970                 975     


Ala Cys Cys Ala Gly Cys Ala Gly Cys Cys Cys Cys Thr Cys Gly Gly 
            980                 985                 990         


Gly Cys Ala Gly Thr Gly Ala Cys  Ala Cys Cys Ala Cys  Cys Thr Ala 
        995                 1000                 1005             


Cys Thr  Thr Cys Thr Cys Cys  Gly Thr Cys Ala Ala  Thr Gly Thr 
    1010                 1015                 1020             


Thr Thr  Cys Ala Gly Ala Thr  Gly Cys Thr Cys Thr  Cys Cys Cys 
    1025                 1030                 1035             


Cys Thr  Cys Cys Thr Cys Gly  Gly Ala Gly Gly Ala  Thr Gly Ala 
    1040                 1045                 1050             


Thr Gly  Ala Thr Gly Ala Thr  Gly Ala Thr Gly Ala  Thr Gly Ala 
    1055                 1060                 1065             


Cys Thr  Cys Cys Thr Cys Thr  Thr Cys Ala Gly Ala  Gly Gly Ala 
    1070                 1075                 1080             


Gly Ala  Ala Ala Gly Ala Ala  Ala Cys Ala Gly Ala  Thr Ala Ala 
    1085                 1090                 1095             


Cys Ala  Cys Cys Ala Ala Ala  Cys Cys Ala Ala Ala  Cys Cys Gly 
    1100                 1105                 1110             


Thr Ala  Thr Gly Cys Cys Cys  Gly Thr Ala Gly Cys  Thr Cys Cys 
    1115                 1120                 1125             


Ala Thr  Ala Thr Thr Gly Gly  Ala Cys Ala Thr Cys  Cys Cys Cys 
    1130                 1135                 1140             


Ala Gly  Ala Ala Ala Ala Gly  Ala Thr Gly Gly Ala  Ala Ala Ala 
    1145                 1150                 1155             


Gly Ala  Ala Ala Thr Thr Gly  Cys Ala Thr Gly Cys  Ala Gly Thr 
    1160                 1165                 1170             


Gly Cys  Cys Gly Gly Cys Thr  Gly Cys Cys Ala Ala  Gly Ala Cys 
    1175                 1180                 1185             


Ala Gly  Thr Gly Ala Ala Gly  Thr Thr Cys Ala Ala  Ala Thr Gly 
    1190                 1195                 1200             


Cys Cys  Cys Thr Thr Cys Cys  Ala Gly Thr Gly Gly  Gly Ala Cys 
    1205                 1210                 1215             


Cys Cys  Cys Ala Ala Ala Cys  Cys Cys Cys Ala Cys  Ala Cys Thr 
    1220                 1225                 1230             


Gly Cys  Gly Cys Thr Gly Gly  Thr Thr Gly Ala Ala  Ala Ala Ala 
    1235                 1240                 1245             


Thr Gly  Gly Cys Ala Ala Ala  Gly Ala Ala Thr Thr  Cys Ala Ala 
    1250                 1255                 1260             


Ala Cys  Cys Thr Gly Ala Cys  Cys Ala Cys Ala Gly  Ala Ala Thr 
    1265                 1270                 1275             


Thr Gly  Gly Ala Gly Gly Cys  Thr Ala Cys Ala Ala  Gly Gly Thr 
    1280                 1285                 1290             


Cys Cys  Gly Thr Thr Ala Thr  Gly Cys Cys Ala Cys  Cys Thr Gly 
    1295                 1300                 1305             


Gly Ala  Gly Cys Ala Thr Cys  Ala Thr Ala Ala Thr  Gly Gly Ala 
    1310                 1315                 1320             


Cys Thr  Cys Thr Gly Thr Gly  Gly Thr Gly Cys Cys  Cys Thr Cys 
    1325                 1330                 1335             


Thr Gly  Ala Cys Ala Ala Gly  Gly Gly Cys Ala Ala  Cys Thr Ala 
    1340                 1345                 1350             


Cys Ala  Cys Cys Thr Gly Cys  Ala Thr Thr Gly Thr  Gly Gly Ala 
    1355                 1360                 1365             


Gly Ala  Ala Thr Gly Ala Gly  Thr Ala Cys Gly Gly  Cys Ala Gly 
    1370                 1375                 1380             


Cys Ala  Thr Cys Ala Ala Cys  Cys Ala Cys Ala Cys  Ala Thr Ala 
    1385                 1390                 1395             


Cys Cys  Ala Gly Cys Thr Gly  Gly Ala Thr Gly Thr  Cys Gly Thr 
    1400                 1405                 1410             


Gly Gly  Ala Gly Cys Gly Gly  Thr Cys Cys Cys Cys  Thr Cys Ala 
    1415                 1420                 1425             


Cys Cys  Gly Gly Cys Cys Cys  Ala Thr Cys Cys Thr  Gly Cys Ala 
    1430                 1435                 1440             


Ala Gly  Cys Ala Gly Gly Gly  Thr Thr Gly Cys Cys  Cys Gly Cys 
    1445                 1450                 1455             


Cys Ala  Ala Cys Ala Ala Ala  Ala Cys Ala Gly Thr  Gly Gly Cys 
    1460                 1465                 1470             


Cys Cys  Thr Gly Gly Gly Thr  Ala Gly Cys Ala Ala  Cys Gly Thr 
    1475                 1480                 1485             


Gly Gly  Ala Gly Thr Thr Cys  Ala Thr Gly Thr Gly  Thr Ala Ala 
    1490                 1495                 1500             


Gly Gly  Thr Gly Thr Ala Cys  Ala Gly Thr Gly Ala  Cys Cys Cys 
    1505                 1510                 1515             


Gly Cys  Ala Gly Cys Cys Gly  Cys Ala Cys Ala Thr  Cys Cys Ala 
    1520                 1525                 1530             


Gly Thr  Gly Gly Cys Thr Ala  Ala Ala Gly Cys Ala  Cys Ala Thr 
    1535                 1540                 1545             


Cys Gly  Ala Gly Gly Thr Gly  Ala Ala Thr Gly Gly  Gly Ala Gly 
    1550                 1555                 1560             


Cys Ala  Ala Gly Ala Thr Thr  Gly Gly Cys Cys Cys  Ala Gly Ala 
    1565                 1570                 1575             


Cys Ala  Ala Cys Cys Thr Gly  Cys Cys Thr Thr Ala  Thr Gly Thr 
    1580                 1585                 1590             


Cys Cys  Ala Gly Ala Thr Cys  Thr Thr Gly Ala Ala  Gly Ala Cys 
    1595                 1600                 1605             


Thr Gly  Cys Thr Gly Gly Ala  Gly Thr Thr Ala Ala  Thr Ala Cys 
    1610                 1615                 1620             


Cys Ala  Cys Cys Gly Ala Cys  Ala Ala Ala Gly Ala  Gly Ala Thr 
    1625                 1630                 1635             


Gly Gly  Ala Gly Gly Thr Gly  Cys Thr Thr Cys Ala  Cys Thr Thr 
    1640                 1645                 1650             


Ala Ala  Gly Ala Ala Ala Thr  Gly Thr Cys Thr Cys  Cys Thr Thr 
    1655                 1660                 1665             


Thr Gly  Ala Gly Gly Ala Cys  Gly Cys Ala Gly Gly  Gly Gly Ala 
    1670                 1675                 1680             


Gly Thr  Ala Thr Ala Cys Gly  Thr Gly Cys Thr Thr  Gly Gly Cys 
    1685                 1690                 1695             


Gly Gly  Gly Thr Ala Ala Cys  Thr Cys Thr Ala Thr  Cys Gly Gly 
    1700                 1705                 1710             


Ala Cys  Thr Cys Thr Cys Cys  Cys Ala Thr Cys Ala  Cys Thr Cys 
    1715                 1720                 1725             


Thr Gly  Cys Ala Thr Gly Gly  Thr Thr Gly Ala Cys  Cys Gly Thr 
    1730                 1735                 1740             


Thr Cys  Thr Gly Gly Ala Ala  Gly Cys Cys Cys Thr  Gly Gly Ala 
    1745                 1750                 1755             


Ala Gly  Ala Gly Ala Gly Gly  Cys Cys Gly Gly Cys  Ala Gly Thr 
    1760                 1765                 1770             


Gly Ala  Thr Gly Ala Cys Cys  Thr Cys Gly Cys Cys  Cys Cys Thr 
    1775                 1780                 1785             


Gly Thr  Ala Cys Cys Thr Gly  Gly Ala Gly Ala Thr  Cys Ala Thr 
    1790                 1795                 1800             


Cys Ala  Thr Cys Thr Ala Thr  Thr Gly Cys Ala Cys  Ala Gly Gly 
    1805                 1810                 1815             


Gly Gly  Cys Cys Thr Thr Cys  Cys Thr Cys Ala Thr  Cys Thr Cys 
    1820                 1825                 1830             


Cys Thr  Gly Cys Ala Thr Gly  Gly Thr Gly Gly Gly  Gly Thr Cys 
    1835                 1840                 1845             


Gly Gly  Thr Cys Ala Thr Cys  Gly Thr Cys Thr Ala  Cys Ala Ala 
    1850                 1855                 1860             


Gly Ala  Thr Gly Ala Ala Gly  Ala Gly Thr Gly Gly  Thr Ala Cys 
    1865                 1870                 1875             


Cys Ala  Ala Gly Ala Ala Gly  Ala Gly Thr Gly Ala  Cys Thr Thr 
    1880                 1885                 1890             


Cys Cys  Ala Cys Ala Gly Cys  Cys Ala Gly Ala Thr  Gly Gly Cys 
    1895                 1900                 1905             


Thr Gly  Thr Gly Cys Ala Cys  Ala Ala Gly Cys Thr  Gly Gly Cys 
    1910                 1915                 1920             


Cys Ala  Ala Gly Ala Gly Cys  Ala Thr Cys Cys Cys  Thr Cys Thr 
    1925                 1930                 1935             


Gly Cys  Gly Cys Ala Gly Ala  Cys Ala Gly Gly Thr  Gly Thr Cys 
    1940                 1945                 1950             


Thr Gly  Cys Thr Gly Ala Cys  Thr Cys Cys Ala Gly  Thr Gly Cys 
    1955                 1960                 1965             


Ala Thr  Cys Cys Ala Thr Gly  Ala Ala Cys Thr Cys  Thr Gly Gly 
    1970                 1975                 1980             


Gly Gly  Thr Thr Cys Thr Thr  Cys Thr Gly Gly Thr  Thr Cys Gly 
    1985                 1990                 1995             


Gly Cys  Cys Ala Thr Cys Ala  Cys Gly Gly Cys Thr  Cys Thr Cys 
    2000                 2005                 2010             


Cys Thr  Cys Cys Ala Gly Thr  Gly Gly Gly Ala Cys  Thr Cys Cys 
    2015                 2020                 2025             


Cys Ala  Thr Gly Cys Thr Ala  Gly Cys Ala Gly Gly  Gly Gly Thr 
    2030                 2035                 2040             


Cys Thr  Cys Thr Gly Ala Gly  Thr Ala Thr Gly Ala  Gly Cys Thr 
    2045                 2050                 2055             


Thr Cys  Cys Cys Gly Ala Ala  Gly Ala Cys Cys Cys  Thr Cys Gly 
    2060                 2065                 2070             


Cys Thr  Gly Gly Gly Ala Gly  Cys Thr Gly Cys Cys  Thr Cys Gly 
    2075                 2080                 2085             


Gly Gly  Ala Cys Ala Gly Ala  Cys Thr Gly Gly Thr  Cys Thr Thr 
    2090                 2095                 2100             


Ala Gly  Gly Cys Ala Ala Ala  Cys Cys Cys Cys Thr  Gly Gly Gly 
    2105                 2110                 2115             


Ala Gly  Ala Gly Gly Gly Cys  Thr Gly Cys Thr Thr  Thr Gly Gly 
    2120                 2125                 2130             


Gly Cys  Ala Gly Gly Thr Gly  Gly Thr Gly Thr Thr  Gly Gly Cys 
    2135                 2140                 2145             


Ala Gly  Ala Gly Gly Cys Thr  Ala Thr Cys Gly Gly  Gly Cys Thr 
    2150                 2155                 2160             


Gly Gly  Ala Cys Ala Ala Gly  Gly Ala Cys Ala Ala  Ala Cys Cys 
    2165                 2170                 2175             


Cys Ala  Ala Cys Cys Gly Thr  Gly Thr Gly Ala Cys  Cys Ala Ala 
    2180                 2185                 2190             


Ala Gly  Thr Gly Gly Cys Thr  Gly Thr Gly Ala Ala  Gly Ala Thr 
    2195                 2200                 2205             


Gly Thr  Thr Gly Ala Ala Gly  Thr Cys Gly Gly Ala  Cys Gly Cys 
    2210                 2215                 2220             


Ala Ala  Cys Ala Gly Ala Gly  Ala Ala Ala Gly Ala  Cys Thr Thr 
    2225                 2230                 2235             


Gly Thr  Cys Ala Gly Ala Cys  Cys Thr Gly Ala Thr  Cys Thr Cys 
    2240                 2245                 2250             


Ala Gly  Ala Ala Ala Thr Gly  Gly Ala Gly Ala Thr  Gly Ala Thr 
    2255                 2260                 2265             


Gly Ala  Ala Gly Ala Thr Gly  Ala Thr Cys Gly Gly  Gly Ala Ala 
    2270                 2275                 2280             


Gly Cys  Ala Thr Ala Ala Gly  Ala Ala Thr Ala Thr  Cys Ala Thr 
    2285                 2290                 2295             


Cys Ala  Ala Cys Cys Thr Gly  Cys Thr Gly Gly Gly  Gly Gly Cys 
    2300                 2305                 2310             


Cys Thr  Gly Cys Ala Cys Gly  Cys Ala Gly Gly Ala  Thr Gly Gly 
    2315                 2320                 2325             


Thr Cys  Cys Cys Thr Thr Gly  Thr Ala Thr Gly Thr  Cys Ala Thr 
    2330                 2335                 2340             


Cys Gly  Thr Gly Gly Ala Gly  Thr Ala Thr Gly Cys  Cys Thr Cys 
    2345                 2350                 2355             


Cys Ala  Ala Gly Gly Gly Cys  Ala Ala Cys Cys Thr  Gly Cys Gly 
    2360                 2365                 2370             


Gly Gly  Ala Gly Thr Ala Cys  Cys Thr Gly Cys Ala  Gly Gly Cys 
    2375                 2380                 2385             


Cys Cys  Gly Gly Ala Gly Gly  Cys Cys Cys Cys Cys  Ala Gly Gly 
    2390                 2395                 2400             


Gly Cys  Thr Gly Gly Ala Ala  Thr Ala Cys Thr Gly  Cys Thr Ala 
    2405                 2410                 2415             


Cys Ala  Ala Cys Cys Cys Cys  Ala Gly Cys Cys Ala  Cys Ala Ala 
    2420                 2425                 2430             


Cys Cys  Cys Ala Gly Ala Gly  Gly Ala Gly Cys Ala  Gly Cys Thr 
    2435                 2440                 2445             


Cys Thr  Cys Cys Thr Cys Cys  Ala Ala Gly Gly Ala  Cys Cys Thr 
    2450                 2455                 2460             


Gly Gly  Thr Gly Thr Cys Cys  Thr Gly Cys Gly Cys  Cys Thr Ala 
    2465                 2470                 2475             


Cys Cys  Ala Gly Gly Thr Gly  Gly Cys Cys Cys Gly  Ala Gly Gly 
    2480                 2485                 2490             


Cys Ala  Thr Gly Gly Ala Gly  Thr Ala Thr Cys Thr  Gly Gly Cys 
    2495                 2500                 2505             


Cys Thr  Cys Cys Ala Ala Gly  Ala Ala Gly Thr Gly  Cys Ala Thr 
    2510                 2515                 2520             


Ala Cys  Ala Cys Cys Gly Ala  Gly Ala Cys Cys Thr  Gly Gly Cys 
    2525                 2530                 2535             


Ala Gly  Cys Cys Ala Gly Gly  Ala Ala Thr Gly Thr  Cys Cys Thr 
    2540                 2545                 2550             


Gly Gly  Thr Gly Ala Cys Ala  Gly Ala Gly Gly Ala  Cys Ala Ala 
    2555                 2560                 2565             


Thr Gly  Thr Gly Ala Thr Gly  Ala Ala Gly Ala Thr  Ala Gly Cys 
    2570                 2575                 2580             


Ala Gly  Ala Cys Thr Thr Thr  Gly Gly Cys Cys Thr  Cys Gly Cys 
    2585                 2590                 2595             


Ala Cys  Gly Gly Gly Ala Cys  Ala Thr Thr Cys Ala  Cys Cys Ala 
    2600                 2605                 2610             


Cys Ala  Thr Cys Gly Ala Cys  Thr Ala Cys Thr Ala  Thr Ala Ala 
    2615                 2620                 2625             


Ala Ala  Ala Gly Ala Cys Ala  Ala Cys Cys Ala Ala  Cys Gly Gly 
    2630                 2635                 2640             


Cys Cys  Gly Ala Cys Thr Gly  Cys Cys Thr Gly Thr  Gly Ala Ala 
    2645                 2650                 2655             


Gly Thr  Gly Gly Ala Thr Gly  Gly Cys Ala Cys Cys  Cys Gly Ala 
    2660                 2665                 2670             


Gly Gly  Cys Ala Thr Thr Ala  Thr Thr Thr Gly Ala  Cys Cys Gly 
    2675                 2680                 2685             


Gly Ala  Thr Cys Thr Ala Cys  Ala Cys Cys Cys Ala  Cys Cys Ala 
    2690                 2695                 2700             


Gly Ala  Gly Thr Gly Ala Thr  Gly Thr Gly Thr Gly  Gly Thr Cys 
    2705                 2710                 2715             


Thr Thr  Thr Cys Gly Gly Gly  Gly Thr Gly Cys Thr  Cys Cys Thr 
    2720                 2725                 2730             


Gly Thr  Gly Gly Gly Ala Gly  Ala Thr Cys Thr Thr  Cys Ala Cys 
    2735                 2740                 2745             


Thr Cys  Thr Gly Gly Gly Cys  Gly Gly Cys Thr Cys  Cys Cys Cys 
    2750                 2755                 2760             


Ala Thr  Ala Cys Cys Cys Cys  Gly Gly Thr Gly Thr  Gly Cys Cys 
    2765                 2770                 2775             


Thr Gly  Thr Gly Gly Ala Gly  Gly Ala Ala Cys Thr  Thr Thr Thr 
    2780                 2785                 2790             


Cys Ala  Ala Gly Cys Thr Gly  Cys Thr Gly Ala Ala  Gly Gly Ala 
    2795                 2800                 2805             


Gly Gly  Gly Thr Cys Ala Cys  Cys Gly Cys Ala Thr  Gly Gly Ala 
    2810                 2815                 2820             


Cys Ala  Ala Gly Cys Cys Cys  Ala Gly Thr Ala Ala  Cys Thr Gly 
    2825                 2830                 2835             


Cys Ala  Cys Cys Ala Ala Cys  Gly Ala Gly Cys Thr  Gly Thr Ala 
    2840                 2845                 2850             


Cys Ala  Thr Gly Ala Thr Gly  Ala Thr Gly Cys Gly  Gly Gly Ala 
    2855                 2860                 2865             


Cys Thr  Gly Cys Thr Gly Gly  Cys Ala Thr Gly Cys  Ala Gly Thr 
    2870                 2875                 2880             


Gly Cys  Cys Cys Thr Cys Ala  Cys Ala Gly Ala Gly  Ala Cys Cys 
    2885                 2890                 2895             


Cys Ala  Cys Cys Thr Thr Cys  Ala Ala Gly Cys Ala  Gly Cys Thr 
    2900                 2905                 2910             


Gly Gly  Thr Gly Gly Ala Ala  Gly Ala Cys Cys Thr  Gly Gly Ala 
    2915                 2920                 2925             


Cys Cys  Gly Cys Ala Thr Cys  Gly Thr Gly Gly Cys  Cys Thr Thr 
    2930                 2935                 2940             


Gly Ala  Cys Cys Thr Cys Cys  Ala Ala Cys Cys Ala  Gly Gly Ala 
    2945                 2950                 2955             


Gly Thr  Ala Cys Cys Thr Gly  Gly Ala Cys Cys Thr  Gly Thr Cys 
    2960                 2965                 2970             


Cys Ala  Thr Gly Cys Cys Cys  Cys Thr Gly Gly Ala  Cys Cys Ala 
    2975                 2980                 2985             


Gly Thr  Ala Cys Thr Cys Cys  Cys Cys Cys Ala Gly  Cys Thr Thr 
    2990                 2995                 3000             


Thr Cys  Cys Cys Gly Ala Cys  Ala Cys Cys Cys Gly  Gly Ala Gly 
    3005                 3010                 3015             


Cys Thr  Cys Thr Ala Cys Gly  Thr Gly Cys Thr Cys  Cys Thr Cys 
    3020                 3025                 3030             


Ala Gly  Gly Gly Gly Ala Gly  Gly Ala Thr Thr Cys  Cys Gly Thr 
    3035                 3040                 3045             


Cys Thr  Thr Cys Thr Cys Thr  Cys Ala Thr Gly Ala  Gly Cys Cys 
    3050                 3055                 3060             


Gly Cys  Thr Gly Cys Cys Cys  Gly Ala Gly Gly Ala  Gly Cys Cys 
    3065                 3070                 3075             


Cys Thr  Gly Cys Cys Thr Gly  Cys Cys Cys Cys Gly  Ala Cys Ala 
    3080                 3085                 3090             


Cys Cys  Cys Ala Gly Cys Cys  Cys Ala Gly Cys Thr  Thr Gly Cys 
    3095                 3100                 3105             


Cys Ala  Ala Thr Gly Gly Cys  Gly Gly Ala Cys Thr  Cys Ala Ala 
    3110                 3115                 3120             


Ala Cys  Gly Cys Cys Gly Cys  Thr Gly Ala Cys Thr  Gly Cys Cys 
    3125                 3130                 3135             


Ala Cys  Cys Cys Ala Cys Ala  Cys Gly Cys Cys Cys  Thr Cys Cys 
    3140                 3145                 3150             


Cys Cys  Ala Gly Ala Cys Thr  Cys Cys Ala Cys Cys  Gly Thr Cys 
    3155                 3160                 3165             


Ala Gly  Cys Thr Gly Thr Ala  Ala Cys Cys Cys Thr  Cys Ala Cys 
    3170                 3175                 3180             


Cys Cys  Ala Cys Ala Gly Cys  Cys Cys Cys Thr Gly  Cys Thr Gly 
    3185                 3190                 3195             


Gly Gly  Cys Cys Cys Ala Cys  Cys Ala Cys Cys Thr  Gly Thr Cys 
    3200                 3205                 3210             


Cys Gly  Thr Cys Cys Cys Thr  Gly Thr Cys Cys Cys  Cys Thr Thr 
    3215                 3220                 3225             


Thr Cys  Cys Thr Gly Cys Thr  Gly Gly Cys Ala Gly  Gly Ala Gly 
    3230                 3235                 3240             


Cys Cys  Gly Gly Cys Thr Gly  Cys Cys Thr Ala Cys  Cys Ala Gly 
    3245                 3250                 3255             


Gly Gly  Gly Cys Cys Thr Thr  Cys Cys Thr Gly Thr  Gly Thr Gly 
    3260                 3265                 3270             


Gly Cys  Cys Thr Gly Cys Cys  Thr Thr Cys Ala Cys  Cys Cys Cys 
    3275                 3280                 3285             


Ala Cys  Thr Cys Ala Gly Cys  Thr Cys Ala Cys Cys  Thr Cys Thr 
    3290                 3295                 3300             


Cys Cys  Cys Thr Cys Cys Ala  Cys Cys Thr Cys Cys  Thr Cys Thr 
    3305                 3310                 3315             


Cys Cys  Ala Cys Cys Thr Gly  Cys Thr Gly Gly Thr  Gly Ala Gly 
    3320                 3325                 3330             


Ala Gly  Gly Thr Gly Cys Ala  Ala Ala Gly Ala Gly  Gly Cys Ala 
    3335                 3340                 3345             


Gly Ala  Thr Cys Thr Thr Thr  Gly Cys Thr Gly Cys  Cys Ala Gly 
    3350                 3355                 3360             


Cys Cys  Ala Cys Thr Thr Cys  Ala Thr Cys Cys Cys  Cys Thr Cys 
    3365                 3370                 3375             


Cys Cys  Ala Gly Ala Thr Gly  Thr Thr Gly Gly Ala  Cys Cys Ala 
    3380                 3385                 3390             


Ala Cys  Ala Cys Cys Cys Cys  Thr Cys Cys Cys Thr  Gly Cys Cys 
    3395                 3400                 3405             


Ala Cys  Cys Ala Gly Gly Cys  Ala Cys Thr Gly Cys  Cys Thr Gly 
    3410                 3415                 3420             


Gly Ala  Gly Gly Gly Cys Ala  Gly Gly Gly Ala Gly  Thr Gly Gly 
    3425                 3430                 3435             


Gly Ala  Gly Cys Cys Ala Ala  Thr Gly Ala Ala Cys  Ala Gly Gly 
    3440                 3445                 3450             


Cys Ala  Thr Gly Cys Ala Ala  Gly Thr Gly Ala Gly  Ala Gly Cys 
    3455                 3460                 3465             


Thr Thr  Cys Cys Thr Gly Ala  Gly Cys Thr Thr Thr  Cys Thr Cys 
    3470                 3475                 3480             


Cys Thr  Gly Thr Cys Gly Gly  Thr Thr Thr Gly Gly  Thr Cys Thr 
    3485                 3490                 3495             


Gly Thr  Thr Thr Thr Gly Cys  Cys Thr Thr Cys Ala  Cys Cys Cys 
    3500                 3505                 3510             


Ala Thr  Ala Ala Gly Cys Cys  Cys Cys Thr Cys Gly  Cys Ala Cys 
    3515                 3520                 3525             


Thr Cys  Thr Gly Gly Thr Gly  Gly Cys Ala Gly Gly  Thr Gly Cys 
    3530                 3535                 3540             


Cys Thr  Thr Gly Thr Cys Cys  Thr Cys Ala Gly Gly  Gly Cys Thr 
    3545                 3550                 3555             


Ala Cys  Ala Gly Cys Ala Gly  Thr Ala Gly Gly Gly  Ala Gly Gly 
    3560                 3565                 3570             


Thr Cys  Ala Gly Thr Gly Cys  Thr Thr Cys Gly Thr  Gly Cys Cys 
    3575                 3580                 3585             


Thr Cys  Gly Ala Thr Thr Gly  Ala Ala Gly Gly Thr  Gly Ala Cys 
    3590                 3595                 3600             


Cys Thr  Cys Thr Gly Cys Cys  Cys Cys Ala Gly Ala  Thr Ala Gly 
    3605                 3610                 3615             


Gly Thr  Gly Gly Thr Gly Cys  Cys Ala Gly Thr Gly  Gly Cys Thr 
    3620                 3625                 3630             


Thr Ala  Thr Thr Ala Ala Thr  Thr Cys Cys Gly Ala  Thr Ala Cys 
    3635                 3640                 3645             


Thr Ala  Gly Thr Thr Thr Gly  Cys Thr Thr Thr Gly  Cys Thr Gly 
    3650                 3655                 3660             


Ala Cys  Cys Ala Ala Ala Thr  Gly Cys Cys Thr Gly  Gly Thr Ala 
    3665                 3670                 3675             


Cys Cys  Ala Gly Ala Gly Gly  Ala Thr Gly Gly Thr  Gly Ala Gly 
    3680                 3685                 3690             


Gly Cys  Gly Ala Ala Gly Gly  Cys Cys Ala Gly Gly  Thr Thr Gly 
    3695                 3700                 3705             


Gly Gly  Gly Gly Cys Ala Gly  Thr Gly Thr Thr Gly  Thr Gly Gly 
    3710                 3715                 3720             


Cys Cys  Cys Thr Gly Gly Gly  Gly Cys Cys Cys Ala  Gly Cys Cys 
    3725                 3730                 3735             


Cys Cys  Ala Ala Ala Cys Thr  Gly Gly Gly Gly Gly  Cys Thr Cys 
    3740                 3745                 3750             


Thr Gly  Thr Ala Thr Ala Thr  Ala Gly Cys Thr Ala  Thr Gly Ala 
    3755                 3760                 3765             


Ala Gly  Ala Ala Ala Ala Cys  Ala Cys Ala Ala Ala  Gly Thr Gly 
    3770                 3775                 3780             


Thr Ala  Thr Ala Ala Ala Thr  Cys Thr Gly Ala Gly  Thr Ala Thr 
    3785                 3790                 3795             


Ala Thr  Ala Thr Thr Thr Ala  Cys Ala Thr Gly Thr  Cys Thr Thr 
    3800                 3805                 3810             


Thr Thr  Thr Ala Ala Ala Ala  Gly Gly Gly Thr Cys  Gly Thr Thr 
    3815                 3820                 3825             


Ala Cys  Cys Ala Gly Ala Gly  Ala Thr Thr Thr Ala  Cys Cys Cys 
    3830                 3835                 3840             


Ala Thr  Cys Gly Gly Gly Thr  Ala Ala Gly Ala Thr  Gly Cys Thr 
    3845                 3850                 3855             


Cys Cys  Thr Gly Gly Thr Gly  Gly Cys Thr Gly Gly  Gly Ala Gly 
    3860                 3865                 3870             


Gly Cys  Ala Thr Cys Ala Gly  Thr Thr Gly Cys Thr  Ala Thr Ala 
    3875                 3880                 3885             


Thr Ala  Thr Thr Ala Ala Ala  Ala Ala Cys Ala Ala  Ala Ala Ala 
    3890                 3895                 3900             


Ala Ala  Ala Ala Ala Ala Ala  Ala Ala Ala 
    3905                 3910             


<210>  23
<211>  508
<212>  PRT
<213>  homo sapiens

<400>  23

Met Gly Ser Cys Cys Ser Cys Pro Asp Lys Asp Thr Val Pro Asp Asn 
1               5                   10                  15      


His Arg Asn Lys Phe Lys Val Ile Asn Val Asp Asp Asp Gly Asn Glu 
            20                  25                  30          


Leu Gly Ser Gly Ile Met Glu Leu Thr Asp Thr Glu Leu Ile Leu Tyr 
        35                  40                  45              


Thr Arg Lys Arg Asp Ser Val Lys Trp His Tyr Leu Cys Leu Arg Arg 
    50                  55                  60                  


Tyr Gly Tyr Asp Ser Asn Leu Phe Ser Phe Glu Ser Gly Arg Arg Cys 
65                  70                  75                  80  


Gln Thr Gly Gln Gly Ile Phe Ala Phe Lys Cys Ala Arg Ala Glu Glu 
                85                  90                  95      


Leu Phe Asn Met Leu Gln Glu Ile Met Gln Asn Asn Ser Ile Asn Val 
            100                 105                 110         


Val Glu Glu Pro Val Val Glu Arg Asn Asn His Gln Thr Glu Leu Glu 
        115                 120                 125             


Val Pro Arg Thr Pro Arg Thr Pro Thr Thr Pro Gly Phe Ala Ala Gln 
    130                 135                 140                 


Asn Leu Pro Asn Gly Tyr Pro Arg Tyr Pro Ser Phe Gly Asp Ala Ser 
145                 150                 155                 160 


Ser His Pro Ser Ser Arg His Pro Ser Val Gly Ser Ala Arg Leu Pro 
                165                 170                 175     


Ser Val Gly Glu Glu Ser Thr His Pro Leu Leu Val Ala Glu Glu Gln 
            180                 185                 190         


Val His Thr Tyr Val Asn Thr Thr Gly Val Gln Glu Glu Arg Lys Asn 
        195                 200                 205             


Arg Thr Ser Val His Val Pro Leu Glu Ala Arg Val Ser Asn Ala Glu 
    210                 215                 220                 


Ser Ser Thr Pro Lys Glu Glu Pro Ser Ser Ile Glu Asp Arg Asp Pro 
225                 230                 235                 240 


Gln Ile Leu Leu Glu Pro Glu Gly Val Lys Phe Val Leu Gly Pro Thr 
                245                 250                 255     


Pro Val Gln Lys Gln Leu Met Glu Lys Glu Lys Leu Glu Gln Leu Gly 
            260                 265                 270         


Arg Asp Gln Val Ser Gly Ser Gly Ala Asn Asn Thr Glu Trp Asp Thr 
        275                 280                 285             


Gly Tyr Asp Ser Asp Glu Arg Arg Asp Ala Pro Ser Val Asn Lys Leu 
    290                 295                 300                 


Val Tyr Glu Asn Ile Asn Gly Leu Ser Ile Pro Ser Ala Ser Gly Val 
305                 310                 315                 320 


Arg Arg Gly Arg Leu Thr Ser Thr Ser Thr Ser Asp Thr Gln Asn Ile 
                325                 330                 335     


Asn Asn Ser Ala Gln Arg Arg Thr Ala Leu Leu Asn Tyr Glu Asn Leu 
            340                 345                 350         


Pro Ser Leu Pro Pro Val Trp Glu Ala Arg Lys Leu Ser Arg Asp Glu 
        355                 360                 365             


Asp Asp Asn Leu Gly Pro Lys Thr Pro Ser Leu Asn Gly Tyr His Asn 
    370                 375                 380                 


Asn Leu Asp Pro Met His Asn Tyr Val Asn Thr Glu Asn Val Thr Val 
385                 390                 395                 400 


Pro Ala Ser Ala His Lys Ile Glu Tyr Ser Arg Arg Arg Asp Cys Thr 
                405                 410                 415     


Pro Thr Val Phe Asn Phe Asp Ile Arg Arg Pro Ser Leu Glu His Arg 
            420                 425                 430         


Gln Leu Asn Tyr Ile Gln Val Asp Leu Glu Gly Gly Ser Asp Ser Asp 
        435                 440                 445             


Asn Pro Gln Thr Pro Lys Thr Pro Thr Thr Pro Leu Pro Gln Thr Pro 
    450                 455                 460                 


Thr Arg Arg Thr Glu Leu Tyr Ala Val Ile Asp Ile Glu Arg Thr Ala 
465                 470                 475                 480 


Ala Met Ser Asn Leu Gln Lys Ala Leu Pro Arg Asp Asp Gly Thr Ser 
                485                 490                 495     


Arg Lys Thr Arg His Asn Ser Thr Asp Leu Pro Met 
            500                 505             


<210>  24
<211>  6676
<212>  DNA
<213>  homo sapiens

<400>  24
aaaacccttc cctcccccgc tcccccggaa gtgcttttcc aagattcggg ccggagagag       60

gccttgtagg cacagcggct gagactcgat ctgctccaag taggggctcc agcgcgggtc      120

ggagtctggg ggttcgcgcc cgccgacccg cgccctgctc cctctcagca cctgggcgga      180

cggttaaatc agcaaacaaa gaaaacatgg tattttgaaa tatgattaaa ctcctgatgc      240

tgcagcagag gctaagaata ttaatggcca gatctagtgc acacatggtc ttctgaagaa      300

gccatgggta gctgttgtag ctgtccagat aaagacactg tcccagataa ccatcggaac      360

aagtttaagg tcattaatgt ggatgatgat gggaatgagt taggttctgg cataatggaa      420

cttacagaca cagaactgat tttatacacc cgcaaacgtg actcagtaaa atggcactac      480

ctctgcctgc gacgctatgg ctatgactcg aatctctttt cttttgaaag tggtcgaagg      540

tgtcaaactg gacaaggaat ctttgccttt aagtgtgccc gtgcagaaga attatttaac      600

atgttgcaag agattatgca aaataatagt ataaatgtgg tggaagagcc agttgtagaa      660

agaaataatc atcagacaga attggaagtc cctagaacac ctcgaacacc tacaactcca      720

ggatttgctg ctcagaactt acctaatgga tatccccgat atccctcatt tggagatgct      780

tcatcccatc cgtcaagcag acatccttct gtgggaagtg ctcgcctgcc ttcagtaggg      840

gaagaatcta cacatccttt gcttgtggct gaggaacaag tacataccta tgtcaacact      900

acaggtgtgc aagaagagcg gaaaaaccgc acaagtgtgc atgttccatt ggaggcgagg      960

gtttctaacg ctgaaagcag cacaccaaaa gaagaaccaa gtagtattga ggacagggat     1020

cctcagattc ttcttgaacc tgaaggagtc aaatttgttt tagggccaac ccctgttcaa     1080

aagcagttaa tggaaaaaga gaaactggag caacttggaa gagatcaagt tagtggaagt     1140

ggagcaaata acacagaatg ggacactggc tatgacagtg atgaacgaag agatgcaccc     1200

tctgttaaca aactggtgta tgaaaatata aatgggctat ctatccctag tgcctcaggg     1260

gtcaggagag gtcgtctgac atccaccagt acctcagata cccagaatat caacaactca     1320

gctcagagaa gaactgcatt attaaactat gaaaatctac catctttgcc tcctgtttgg     1380

gaagcccgca agctaagtag ggatgaagat gacaatttag gaccaaagac cccatctcta     1440

aatggctacc ataataatct agatccaatg cataactatg taaatacaga gaatgtaaca     1500

gtgccagcaa gtgctcacaa aatagaatat tcaaggcgtc gggactgtac accaacagtc     1560

tttaactttg atatcagacg cccaagttta gaacacaggc agcttaatta catacaggtt     1620

gacttggaag gtggcagtga ctctgacaac cctcagactc caaaaacgcc tacaactccc     1680

cttccacaaa cccctaccag gcgcacagag ctgtatgccg tgatagacat cgagagaact     1740

gctgctatgt caaatttgca gaaagcactg ccacgagatg atggtacatc taggaaaact     1800

agacacaata gtactgatct gcccatgtga gcctggaaag cattgtgttg tttgcacctt     1860

tgtgaagttt ttaaaaatga agatgcaagt gcttcatttt catttctaaa cactaactcc     1920

ttttatagac tgataaaatt tttttctgaa tatttcatgt gcatctttaa ctaaagggaa     1980

ttaatgtaga gcaggtactc cttaaagaac actaatttca ttatatacta ctcgttgtac     2040

agcagcattc ccgttttcac agtgcctatt taaaatgaga gttgaagtaa atgacatgct     2100

ggttgatttt tatcaatatt ctggacttaa cgcatacctt tcatgtctaa gtcatggttg     2160

gcttttaaaa ctttttataa agcctcttga caatgtacat tgctaacagg taactatagg     2220

ctttgaaagt aatgctcgta gattcagtgt tcacagtatg tggcctccag catgtaacat     2280

gaggaatcct ttatttcatt aattaatggc tttttgactt gagccaaaac atatgtaaag     2340

gaaacagaag taccgcacct cctcttacac cagtcagctc ctttgccttc agtgttacta     2400

gaaagcggcc tgtgtccatg agtgtgcttt gctgttggtg cactgaaagg caggaaggag     2460

acaagatttt ctatttactc atctcatgat gtcatttgaa gggcatgtcc agatatctta     2520

aaattataat aggctcaaga atcagtctca ggtcacttta cccaaaaaca tttgaaaatc     2580

tgaaccacaa tctcctgaaa gtttttctcc tatagattgt tgacaacaca ttgttttctg     2640

gaggcatttg tgccattagg tttccattta tcttcagttt ttttctttgg tgtttgggat     2700

gtcttatttt gttgccttat gtccttttca atttaaaatg tttgagtttg tatatagttt     2760

tgaaattgga ttatgtgttc attgttgttt agtttgcatt tttgtcaaat tatggttttg     2820

aaggttcatt tggaacttac tgttagtctg taacagggtt gcccttgtcc agtatttatt     2880

tataagctgt ttacttttca agttgataaa aacattctcc aattctaaat ttgcttgtgt     2940

ccataggtga tctctttagc aaactgagaa aaaaaggaag ctacttttaa catgcaaagt     3000

tccctcaagg tgtaccgtgt tgtctctgtg ggcactcttc cccagcactt tagcagtaat     3060

tcccccagct acacgctgca gttgtactct gcccactcta gtgttcctca gctctgctgt     3120

ccttttactt gtagctggat ctttgattat ccttcgattt ccatgaaata ttaatattgt     3180

tgccagcata gcaggtacag tggaagtctt gtagcagtga gattgtatca taatttagga     3240

tttaaaatga attaaagttt atataaactg aagagtctcc atatgtcaaa ctcttggaaa     3300

atcaaagatg ttccaatttc ctaaacacta gagaatacga gagaaggtag agtggaaaag     3360

gttaggtaac cttgcaaaat attttactat tttctctaaa tatgaggaag tttgagatta     3420

tgatctggat ctaccagata taactaaggt taatttagca tgaaaaagtt ttagtcatat     3480

tggcatccaa cctattcagt aaccgaatca taggacaatg atggattagg agaacaatag     3540

agtgggatca ttataaagaa aataaattat taaaggtgtc tttatcgttt tagtgccatt     3600

tttagtgtct ttactataaa tcaatatcag tgtattttat cattctatgt gcatagcaga     3660

attttctttt ctcccttttg ttcccctgtg aacttggtgc ttattaaagt gctcactgtt     3720

ctcttaaaag agagcagtgg tataggtgtg cagtttccat gatgcaggtt ccatttttaa     3780

tatattgttc cacttatcct ttcttctgag taaattgcta attgtgccaa atttatgtaa     3840

tagtttttgt aatgtggaat aagaattatg atggaaccat tgcacatttt tttctgaaac     3900

agccagtcaa ggcagaacat taatctccaa atgcaagggc tgatctattt attcattttg     3960

gaggttgggt actttattct ttctttccgt catccttttc attgtttccc ccggattcta     4020

attagttttt atttttttta gataactcca atataatcat tacagtttat gctttaaata     4080

ctatgtgctt taaaaaggaa aatgggacca atttgtctgc taagaatttg attttaggta     4140

ctataagagt attaggaaaa tatatacaac tggtgttaat ttctagatat tttctagaaa     4200

tcacttgtgt tcctatttaa taaaaggtaa tttagaatac tacttgtcct ttgcagtagt     4260

ttagtaatgg gcattaagct gtgtcctcga aggatgtacc tattactagg tgcattttag     4320

aatgaaatat tgatatttta ttagcatata attgtggcca tatatctcag attttctgag     4380

gcagatctaa ttttagataa ttctgttggt agaccatgtg atccttcttt ttggttttgg     4440

aaatataatc attgttaatg ttttccctcc aaatagaata ctgttttatc catacaaatc     4500

ataacagcat ctatcccatg ctagggttgg aaactgatat tggtattact tgtgtttttt     4560

cttagtgtgt tttatttccc agtttcatct tcttctaaaa atgaaaatat ggtgccttcc     4620

ctccctccag gaagactggc aaatatttcc ttttatttac tgctgctgtg gagtgatgag     4680

atatgcactt tactctttaa gattcagcaa aaagcttttc acttctcagt atatccagaa     4740

tacatcatat ctgggactta ggaaaatttg ccaagcaatc tttgttttta tagatactaa     4800

tgttgaccct ctccagcgtt caatgttata aatagaacaa gtcaagctag tgtttatctc     4860

ctccccctcc ccaaaactgt ggcacagcat ataaaaatgt acctcaataa tgttctatta     4920

aaaatgggac aggggcctta tgttttcata atttcccaac aatgtgccgc catatttttg     4980

cctcaaggta aaggttttaa cagatgaaaa agtacttccc aattcccccg tgctattcct     5040

aacctataat gcccaaatgt tttgtgcaat gtgtagtgtg tgtgtataaa tacatatatt     5100

cttgaaatag acataccatc agagacatca ttcacaagta actgatgtat tggcatctca     5160

ttcatatttc tgatgtgtga ggtatatggt actaattacc ttttccttga tgtttgccaa     5220

atttgaataa aggcattggt acgaaattac agaatgtaaa gaaaatgttt ttggcttgaa     5280

aaattaacat attttatgac gtaccacagt atactctgcc caaaccagca ccctatctat     5340

ctttcctgtt ctttacatcc ctgttcccca tccctacttc ctcatttttg gtataacaca     5400

gttcttttgt agcatcatta taattgcagt tctatggcaa ttggacagtt atagcatgga     5460

aacagactgg tataagtagt acagtagtca ccagtgtgcc acatttgcat tagtaatgca     5520

aaatatacat tttataaagg acaaactttg tgttatgttt tattttcatt acattgtata     5580

atattgtaag actattgtat gtcctaattt gcattataaa tgtttttttc ctacgtaaag     5640

gcataaatat agcaactttg tataaaggta gcttattaga tttttaattt tttcttttat     5700

aaaaaattgt ccaacagtgg gactaccatt gccaaattgt atatgaaata tgaattttac     5760

ccccatggtt aatttctttt ataaacattc catatttctc taataaaaag acataagtga     5820

tactgtacta tgcatacatt gtatcttaat gctgtttcag atcagcattt taaattttgg     5880

tttgcatttt taatattggc aaaacgtaac cactgttaat taaaataaaa ccttgttgta     5940

tatgtaacaa cataattttc cctctatccc ttcccaccct ttgttctcta tttctcccta     6000

tcagtgccaa cttcatacat tttgtagcat ggcaataaaa tataactttt acactgaggc     6060

cgagtgtggc tttttggagg aagtggggat gggacgattg ccctctagtt gtcctttgca     6120

tatgactgtt ttttgccata taagccatgt catcaggcat gaaaagtttt ctcatatatg     6180

atgtaaactt gcttttaagg acaagtgtga atgtgctttt taagcttaat ttttgtcatg     6240

acaactaatt ttttttatct ttggagaagt cagagttctt tacaatcaaa cgtttattaa     6300

ctggagtact tagaataagc tagtaattga atttagttca agggctaagc aacacatttt     6360

taaatcctta tttattgtag agtattagta tactgtccta caaattatgt aaaatatggt     6420

ttaatattag atgactttgg attttgcaat gccttactgt tgtcattcta gcataaatat     6480

ccataatgag gtactcaagt tgatactgga agctgagctg atcatacact gacctgaagc     6540

attcatgaaa agctgcttta ttgaataaag tctgattgga gttcttttca tgctcacttt     6600

ccccttattg ctgaaagtag attgcaataa aaccccaata aaacgtttgg tcggatatct     6660

acttaaaaaa aaaaaa                                                     6676


<210>  25
<211>  390
<212>  PRT
<213>  homo sapiens

<400>  25

Met Pro Pro Ser Gly Leu Arg Leu Leu Leu Leu Leu Leu Pro Leu Leu 
1               5                   10                  15      


Trp Leu Leu Val Leu Thr Pro Gly Arg Pro Ala Ala Gly Leu Ser Thr 
            20                  25                  30          


Cys Lys Thr Ile Asp Met Glu Leu Val Lys Arg Lys Arg Ile Glu Ala 
        35                  40                  45              


Ile Arg Gly Gln Ile Leu Ser Lys Leu Arg Leu Ala Ser Pro Pro Ser 
    50                  55                  60                  


Gln Gly Glu Val Pro Pro Gly Pro Leu Pro Glu Ala Val Leu Ala Leu 
65                  70                  75                  80  


Tyr Asn Ser Thr Arg Asp Arg Val Ala Gly Glu Ser Ala Glu Pro Glu 
                85                  90                  95      


Pro Glu Pro Glu Ala Asp Tyr Tyr Ala Lys Glu Val Thr Arg Val Leu 
            100                 105                 110         


Met Val Glu Thr His Asn Glu Ile Tyr Asp Lys Phe Lys Gln Ser Thr 
        115                 120                 125             


His Ser Ile Tyr Met Phe Phe Asn Thr Ser Glu Leu Arg Glu Ala Val 
    130                 135                 140                 


Pro Glu Pro Val Leu Leu Ser Arg Ala Glu Leu Arg Leu Leu Arg Leu 
145                 150                 155                 160 


Lys Leu Lys Val Glu Gln His Val Glu Leu Tyr Gln Lys Tyr Ser Asn 
                165                 170                 175     


Asn Ser Trp Arg Tyr Leu Ser Asn Arg Leu Leu Ala Pro Ser Asp Ser 
            180                 185                 190         


Pro Glu Trp Leu Ser Phe Asp Val Thr Gly Val Val Arg Gln Trp Leu 
        195                 200                 205             


Ser Arg Gly Gly Glu Ile Glu Gly Phe Arg Leu Ser Ala His Cys Ser 
    210                 215                 220                 


Cys Asp Ser Arg Asp Asn Thr Leu Gln Val Asp Ile Asn Gly Phe Thr 
225                 230                 235                 240 


Thr Gly Arg Arg Gly Asp Leu Ala Thr Ile His Gly Met Asn Arg Pro 
                245                 250                 255     


Phe Leu Leu Leu Met Ala Thr Pro Leu Glu Arg Ala Gln His Leu Gln 
            260                 265                 270         


Ser Ser Arg His Arg Arg Ala Leu Asp Thr Asn Tyr Cys Phe Ser Ser 
        275                 280                 285             


Thr Glu Lys Asn Cys Cys Val Arg Gln Leu Tyr Ile Asp Phe Arg Lys 
    290                 295                 300                 


Asp Leu Gly Trp Lys Trp Ile His Glu Pro Lys Gly Tyr His Ala Asn 
305                 310                 315                 320 


Phe Cys Leu Gly Pro Cys Pro Tyr Ile Trp Ser Leu Asp Thr Gln Tyr 
                325                 330                 335     


Ser Lys Val Leu Ala Leu Tyr Asn Gln His Asn Pro Gly Ala Ser Ala 
            340                 345                 350         


Ala Pro Cys Cys Val Pro Gln Ala Leu Glu Pro Leu Pro Ile Val Tyr 
        355                 360                 365             


Tyr Val Gly Arg Lys Pro Lys Val Glu Gln Leu Ser Asn Met Ile Val 
    370                 375                 380                 


Arg Ser Cys Lys Cys Ser 
385                 390 


<210>  26
<211>  1746
<212>  DNA
<213>  homo sapiens

<400>  26
cccagacctc gggcgcaccc cctgcacgcc gccttcatcc ccggcctgtc tcctgagccc       60

ccgcgcatcc tagacccttt ctcctccagg agacggatct ctctccgacc tgccacagat      120

cccctattca agaccaccca ccttctggta ccagatcgcg cccatctagg ttatttccgt      180

gggatactga gacacccccg gtccaagcct cccctccacc actgcgccct tctccctgag      240

gacctcagct ttccctcgag gccctcctac cttttgccgg gagaccccca gcccctgcag      300

gggcggggcc tccccaccac accagccctg ttcgcgctct cggcagtgcc ggggggcgcc      360

gcctccccca tgccgccctc cgggctgcgg ctgctgctgc tgctgctacc gctgctgtgg      420

ctactggtgc tgacgcctgg ccggccggcc gcgggactat ccacctgcaa gactatcgac      480

atggagctgg tgaagcggaa gcgcatcgag gccatccgcg gccagatcct gtccaagctg      540

cggctcgcca gccccccgag ccagggggag gtgccgcccg gcccgctgcc cgaggccgtg      600

ctcgccctgt acaacagcac ccgcgaccgg gtggccgggg agagtgcaga accggagccc      660

gagcctgagg ccgactacta cgccaaggag gtcacccgcg tgctaatggt ggaaacccac      720

aacgaaatct atgacaagtt caagcagagt acacacagca tatatatgtt cttcaacaca      780

tcagagctcc gagaagcggt acctgaaccc gtgttgctct cccgggcaga gctgcgtctg      840

ctgaggctca agttaaaagt ggagcagcac gtggagctgt accagaaata cagcaacaat      900

tcctggcgat acctcagcaa ccggctgctg gcacccagcg actcgccaga gtggttatct      960

tttgatgtca ccggagttgt gcggcagtgg ttgagccgtg gaggggaaat tgagggcttt     1020

cgccttagcg cccactgctc ctgtgacagc agggataaca cactgcaagt ggacatcaac     1080

gggttcacta ccggccgccg aggtgacctg gccaccattc atggcatgaa ccggcctttc     1140

ctgcttctca tggccacccc gctggagagg gcccagcatc tgcaaagctc ccggcaccgc     1200

cgagccctgg acaccaacta ttgcttcagc tccacggaga agaactgctg cgtgcggcag     1260

ctgtacattg acttccgcaa ggacctcggc tggaagtgga tccacgagcc caagggctac     1320

catgccaact tctgcctcgg gccctgcccc tacatttgga gcctggacac gcagtacagc     1380

aaggtcctgg ccctgtacaa ccagcataac ccgggcgcct cggcggcgcc gtgctgcgtg     1440

ccgcaggcgc tggagccgct gcccatcgtg tactacgtgg gccgcaagcc caaggtggag     1500

cagctgtcca acatgatcgt gcgctcctgc aagtgcagct gaggtcccgc cccgccccgc     1560

cccgccccgg caggcccggc cccaccccgc cccgcccccg ctgccttgcc catgggggct     1620

gtatttaagg acacccgtgc cccaagccca cctggggccc cattaaagat ggagagagga     1680

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1740

aaaaaa                                                                1746


<210>  27
<211>  413
<212>  PRT
<213>  homo sapiens

<400>  27

Met His Tyr Cys Val Leu Ser Ala Phe Leu Ile Leu His Leu Val Thr 
1               5                   10                  15      


Val Ala Leu Ser Leu Ser Thr Cys Ser Thr Leu Asp Met Asp Gln Phe 
            20                  25                  30          


Met Arg Lys Arg Ile Glu Ala Ile Arg Gly Gln Ile Leu Ser Lys Leu 
        35                  40                  45              


Lys Leu Thr Ser Pro Pro Glu Asp Tyr Pro Glu Pro Glu Glu Val Pro 
    50                  55                  60                  


Pro Glu Val Ile Ser Ile Tyr Asn Ser Thr Arg Asp Leu Leu Gln Glu 
65                  70                  75                  80  


Lys Ala Ser Arg Arg Ala Ala Ala Cys Glu Arg Glu Arg Ser Asp Glu 
                85                  90                  95      


Glu Tyr Tyr Ala Lys Glu Val Tyr Lys Ile Asp Met Pro Pro Phe Phe 
            100                 105                 110         


Pro Ser Glu Ala Ile Pro Pro Thr Phe Tyr Arg Pro Tyr Phe Arg Ile 
        115                 120                 125             


Val Arg Phe Asp Val Ser Ala Met Glu Lys Asn Ala Ser Asn Leu Val 
    130                 135                 140                 


Lys Ala Glu Phe Arg Val Phe Arg Leu Gln Asn Pro Lys Ala Arg Val 
145                 150                 155                 160 


Pro Glu Gln Arg Ile Glu Leu Tyr Gln Ile Leu Lys Ser Lys Asp Leu 
                165                 170                 175     


Thr Ser Pro Thr Gln Arg Tyr Ile Asp Ser Lys Val Val Lys Thr Arg 
            180                 185                 190         


Ala Glu Gly Glu Trp Leu Ser Phe Asp Val Thr Asp Ala Val His Glu 
        195                 200                 205             


Trp Leu His His Lys Asp Arg Asn Leu Gly Phe Lys Ile Ser Leu His 
    210                 215                 220                 


Cys Pro Cys Cys Thr Phe Val Pro Ser Asn Asn Tyr Ile Ile Pro Asn 
225                 230                 235                 240 


Lys Ser Glu Glu Leu Glu Ala Arg Phe Ala Gly Ile Asp Gly Thr Ser 
                245                 250                 255     


Thr Tyr Thr Ser Gly Asp Gln Lys Thr Ile Lys Ser Thr Arg Lys Lys 
            260                 265                 270         


Asn Ser Gly Lys Thr Pro His Leu Leu Leu Met Leu Leu Pro Ser Tyr 
        275                 280                 285             


Arg Leu Glu Ser Gln Gln Thr Asn Arg Arg Lys Lys Arg Ala Leu Asp 
    290                 295                 300                 


Ala Ala Tyr Cys Phe Arg Asn Val Gln Asp Asn Cys Cys Leu Arg Pro 
305                 310                 315                 320 


Leu Tyr Ile Asp Phe Lys Arg Asp Leu Gly Trp Lys Trp Ile His Glu 
                325                 330                 335     


Pro Lys Gly Tyr Asn Ala Asn Phe Cys Ala Gly Ala Cys Pro Tyr Leu 
            340                 345                 350         


Trp Ser Ser Asp Thr Gln His Ser Arg Val Leu Ser Leu Tyr Asn Thr 
        355                 360                 365             


Ile Asn Pro Glu Ala Ser Ala Ser Pro Cys Cys Val Ser Gln Asp Leu 
    370                 375                 380                 


Glu Pro Leu Thr Ile Leu Tyr Tyr Ile Gly Lys Thr Pro Lys Ile Glu 
385                 390                 395                 400 


Gln Leu Ser Asn Met Ile Val Lys Ser Cys Lys Cys Ser 
                405                 410             


<210>  28
<211>  2570
<212>  DNA
<213>  homo sapiens

<400>  28
gcccctcccg tcagttcgcc agctgccagc cccgggacct tttcatctct tcccttttgg       60

ccggaggagc cgagttcaga tccgccactc cgcacccgag actgacacac tgaactccac      120

ttcctcctct taaatttatt tctacttaat agccactcgt ctcttttttt ccccatctca      180

ttgctccaag aatttttttc ttcttactcg ccaaagtcag ggttccctct gcccgtcccg      240

tattaatatt tccacttttg gaactactgg ccttttcttt ttaaaggaat tcaagcagga      300

tacgtttttc tgttgggcat tgactagatt gtttgcaaaa gtttcgcatc aaaaacaaca      360

acaacaaaaa accaaacaac tctccttgat ctatactttg agaattgttg atttcttttt      420

tttattctga cttttaaaaa caactttttt ttccactttt ttaaaaaatg cactactgtg      480

tgctgagcgc ttttctgatc ctgcatctgg tcacggtcgc gctcagcctg tctacctgca      540

gcacactcga tatggaccag ttcatgcgca agaggatcga ggcgatccgc gggcagatcc      600

tgagcaagct gaagctcacc agtcccccag aagactatcc tgagcccgag gaagtccccc      660

cggaggtgat ttccatctac aacagcacca gggacttgct ccaggagaag gcgagccgga      720

gggcggccgc ctgcgagcgc gagaggagcg acgaagagta ctacgccaag gaggtttaca      780

aaatagacat gccgcccttc ttcccctccg aaactgtctg cccagttgtt acaacaccct      840

ctggctcagt gggcagcttg tgctccagac agtcccaggt gctctgtggg taccttgatg      900

ccatcccgcc cactttctac agaccctact tcagaattgt tcgatttgac gtctcagcaa      960

tggagaagaa tgcttccaat ttggtgaaag cagagttcag agtctttcgt ttgcagaacc     1020

caaaagccag agtgcctgaa caacggattg agctatatca gattctcaag tccaaagatt     1080

taacatctcc aacccagcgc tacatcgaca gcaaagttgt gaaaacaaga gcagaaggcg     1140

aatggctctc cttcgatgta actgatgctg ttcatgaatg gcttcaccat aaagacagga     1200

acctgggatt taaaataagc ttacactgtc cctgctgcac ttttgtacca tctaataatt     1260

acatcatccc aaataaaagt gaagaactag aagcaagatt tgcaggtatt gatggcacct     1320

ccacatatac cagtggtgat cagaaaacta taaagtccac taggaaaaaa aacagtggga     1380

agaccccaca tctcctgcta atgttattgc cctcctacag acttgagtca caacagacca     1440

accggcggaa gaagcgtgct ttggatgcgg cctattgctt tagaaatgtg caggataatt     1500

gctgcctacg tccactttac attgatttca agagggatct agggtggaaa tggatacacg     1560

aacccaaagg gtacaatgcc aacttctgtg ctggagcatg cccgtattta tggagttcag     1620

acactcagca cagcagggtc ctgagcttat ataataccat aaatccagaa gcatctgctt     1680

ctccttgctg cgtgtcccaa gatttagaac ctctaaccat tctctactac attggcaaaa     1740

cacccaagat tgaacagctt tctaatatga ttgtaaagtc ttgcaaatgc agctaaaatt     1800

cttggaaaag tggcaagacc aaaatgacaa tgatgatgat aatgatgatg acgacgacaa     1860

cgatgatgct tgtaacaaga aaacataaga gagccttggt tcatcagtgt taaaaaattt     1920

ttgaaaaggc ggtactagtt cagacacttt ggaagtttgt gttctgtttg ttaaaactgg     1980

catctgacac aaaaaaagtt gaaggcctta ttctacattt cacctacttt gtaagtgaga     2040

gagacaagaa gcaaattttt tttaaagaaa aaaataaaca ctggaagaat ttattagtgt     2100

taattatgtg aacaacgaca acaacaacaa caacaacaaa caggaaaatc ccattaagtg     2160

gagttgctgt acgtaccgtt cctatcccgc gcctcacttg atttttctgt attgctatgc     2220

aataggcacc cttcccattc ttactcttag agttaacagt gagttattta ttgtgtgtta     2280

ctatataatg aacgtttcat tgcccttgga aaataaaaca ggtgtataaa gtggagacca     2340

aatactttgc cagaaactca tggatggctt aaggaacttg aactcaaacg agccagaaaa     2400

aaagaggtca tattaatggg atgaaaaccc aagtgagtta ttatatgacc gagaaagtct     2460

gcattaagat aaagaccctg aaaacacatg ttatgtatca gctgcctaag gaagcttctt     2520

gtaaggtcca aaaactaaaa agactgttaa taaaagaaac tttcagtcag                2570


<210>  29
<211>  412
<212>  PRT
<213>  homo sapiens

<400>  29

Met Lys Met His Leu Gln Arg Ala Leu Val Val Leu Ala Leu Leu Asn 
1               5                   10                  15      


Phe Ala Thr Val Ser Leu Ser Leu Ser Thr Cys Thr Thr Leu Asp Phe 
            20                  25                  30          


Gly His Ile Lys Lys Lys Arg Val Glu Ala Ile Arg Gly Gln Ile Leu 
        35                  40                  45              


Ser Lys Leu Arg Leu Thr Ser Pro Pro Glu Pro Thr Val Met Thr His 
    50                  55                  60                  


Val Pro Tyr Gln Val Leu Ala Leu Tyr Asn Ser Thr Arg Glu Leu Leu 
65                  70                  75                  80  


Glu Glu Met His Gly Glu Arg Glu Glu Gly Cys Thr Gln Glu Asn Thr 
                85                  90                  95      


Glu Ser Glu Tyr Tyr Ala Lys Glu Ile His Lys Phe Asp Met Ile Gln 
            100                 105                 110         


Gly Leu Ala Glu His Asn Glu Leu Ala Val Cys Pro Lys Gly Ile Thr 
        115                 120                 125             


Ser Lys Val Phe Arg Phe Asn Val Ser Ser Val Glu Lys Asn Arg Thr 
    130                 135                 140                 


Asn Leu Phe Arg Ala Glu Phe Arg Val Leu Arg Val Pro Asn Pro Ser 
145                 150                 155                 160 


Ser Lys Arg Asn Glu Gln Arg Ile Glu Leu Phe Gln Ile Leu Arg Pro 
                165                 170                 175     


Asp Glu His Ile Ala Lys Gln Arg Tyr Ile Gly Gly Lys Asn Leu Pro 
            180                 185                 190         


Thr Arg Gly Thr Ala Glu Trp Leu Ser Phe Asp Val Thr Asp Thr Val 
        195                 200                 205             


Arg Glu Trp Leu Leu Arg Arg Glu Ser Asn Leu Gly Leu Glu Ile Ser 
    210                 215                 220                 


Ile His Cys Pro Cys His Thr Phe Gln Pro Asn Gly Asp Ile Leu Glu 
225                 230                 235                 240 


Asn Ile His Glu Val Met Glu Ile Lys Phe Lys Gly Val Asp Asn Glu 
                245                 250                 255     


Asp Asp His Gly Arg Gly Asp Leu Gly Arg Leu Lys Lys Gln Lys Asp 
            260                 265                 270         


His His Asn Pro His Leu Ile Leu Met Met Ile Pro Pro His Arg Leu 
        275                 280                 285             


Asp Asn Pro Gly Gln Gly Gly Gln Arg Lys Lys Arg Ala Leu Asp Thr 
    290                 295                 300                 


Asn Tyr Cys Phe Arg Asn Leu Glu Glu Asn Cys Cys Val Arg Pro Leu 
305                 310                 315                 320 


Tyr Ile Asp Phe Arg Gln Asp Leu Gly Trp Lys Trp Val His Glu Pro 
                325                 330                 335     


Lys Gly Tyr Tyr Ala Asn Phe Cys Ser Gly Pro Cys Pro Tyr Leu Arg 
            340                 345                 350         


Ser Ala Asp Thr Thr His Ser Thr Val Leu Gly Leu Tyr Asn Thr Leu 
        355                 360                 365             


Asn Pro Glu Ala Ser Ala Ser Pro Cys Cys Val Pro Gln Asp Leu Glu 
    370                 375                 380                 


Pro Leu Thr Ile Leu Tyr Tyr Val Gly Arg Thr Pro Lys Val Glu Gln 
385                 390                 395                 400 


Leu Ser Asn Met Val Val Lys Ser Cys Lys Cys Ser 
                405                 410         


<210>  30
<211>  930
<212>  DNA
<213>  homo sapiens

<400>  30
atgaagatgc acttgcaaag ggctctggtg gtcctggccc tgctgaactt tgccacggtc       60

agcctctctc tgtccacttg caccaccttg gacttcggcc acatcaagaa gaagagggtg      120

gaagccatta ggggacagat cttgagcaag ctcaggctca ccagcccccc tgagccaacg      180

gtgatgaccc acgtccccta tcaggtcctg gccctttaca acagcacccg ggagctgctg      240

gaggagatgc atggggagag ggaggaaggc tgcacccagg aaaacaccga gtcggaatac      300

tatgccaaag aaatccataa attcgacatg atccaggggc tggcggagca caacgaactg      360

gctgtctgcc ctaaaggaat tacctccaag gttttccgct tcaatgtgtc ctcagtggag      420

aaaaatagaa ccaacctatt ccgagcagaa ttccgggtct tgcgggtgcc caaccccagc      480

tctaagcgga atgagcagag gatcgagctc ttccagatcc ttcggccaga tgagcacatt      540

gccaaacagc gctatatcgg tggcaagaat ctgcccacac ggggcactgc cgagtggctg      600

tcctttgatg tcactgacac tgtgcgtgag tggctgttga gaagagagtc caacttaggt      660

ctagaaatca gcattcactg tccatgtcac acctttcagc ccaatggaga tatcctggaa      720

aacattcacg aggtgatgga aatcaaattc aaaggcgtgg acaatgagga tgaccatggc      780

cgtggagatc tggggcgcct caagaagcag aaggatcacc acaaccctca tctaatcctc      840

atgatgattc ccccacaccg gctcgacaac ccgggccagg ggggtcagag gaagaagcgg      900

gctttggaca ccaattactg cttccggtag                                       930


<210>  31
<211>  426
<212>  PRT
<213>  homo sapiens

<400>  31

Met Glu Ala Ala Val Ala Ala Pro Arg Pro Arg Leu Leu Leu Leu Val 
1               5                   10                  15      


Leu Ala Ala Ala Ala Ala Ala Ala Ala Ala Leu Leu Pro Gly Ala Thr 
            20                  25                  30          


Ala Leu Gln Cys Phe Cys His Leu Cys Thr Lys Asp Asn Phe Thr Cys 
        35                  40                  45              


Val Thr Asp Gly Leu Cys Phe Val Ser Val Thr Glu Thr Thr Asp Lys 
    50                  55                  60                  


Val Ile His Asn Ser Met Cys Ile Ala Glu Ile Asp Leu Ile Pro Arg 
65                  70                  75                  80  


Asp Arg Pro Phe Val Cys Ala Pro Ser Ser Lys Thr Gly Ser Val Thr 
                85                  90                  95      


Thr Thr Tyr Cys Cys Asn Gln Asp His Cys Asn Lys Ile Glu Leu Pro 
            100                 105                 110         


Thr Thr Gly Leu Pro Leu Leu Val Gln Arg Thr Ile Ala Arg Thr Ile 
        115                 120                 125             


Val Leu Gln Glu Ser Ile Gly Lys Gly Arg Phe Gly Glu Val Trp Arg 
    130                 135                 140                 


Gly Lys Trp Arg Gly Glu Glu Val Ala Val Lys Ile Phe Ser Ser Arg 
145                 150                 155                 160 


Glu Glu Arg Ser Trp Phe Arg Glu Ala Glu Ile Tyr Gln Thr Val Met 
                165                 170                 175     


Leu Arg His Glu Asn Ile Leu Gly Phe Ile Ala Ala Asp Asn Lys Asp 
            180                 185                 190         


Asn Gly Thr Trp Thr Gln Leu Trp Leu Val Ser Asp Tyr His Glu His 
        195                 200                 205             


Gly Ser Leu Phe Asp Tyr Leu Asn Arg Tyr Thr Val Thr Val Glu Gly 
    210                 215                 220                 


Met Ile Lys Leu Ala Leu Ser Thr Ala Ser Gly Leu Ala His Leu His 
225                 230                 235                 240 


Met Glu Ile Val Gly Thr Gln Gly Lys Pro Ala Ile Ala His Arg Asp 
                245                 250                 255     


Leu Lys Ser Lys Asn Ile Leu Val Lys Lys Asn Gly Thr Cys Cys Ile 
            260                 265                 270         


Ala Asp Leu Gly Leu Ala Val Arg His Asp Ser Ala Thr Asp Thr Ile 
        275                 280                 285             


Asp Ile Ala Pro Asn His Arg Val Gly Thr Lys Arg Tyr Met Ala Pro 
    290                 295                 300                 


Glu Val Leu Asp Asp Ser Ile Asn Met Lys His Phe Glu Ser Phe Lys 
305                 310                 315                 320 


Arg Ala Asp Ile Tyr Ala Met Gly Leu Val Phe Trp Glu Ile Ala Arg 
                325                 330                 335     


Arg Cys Ser Ile Gly Gly Ile His Glu Asp Tyr Gln Leu Pro Tyr Tyr 
            340                 345                 350         


Asp Leu Val Pro Ser Asp Pro Ser Val Glu Glu Met Arg Lys Val Val 
        355                 360                 365             


Cys Glu Gln Lys Leu Arg Pro Asn Ile Pro Asn Arg Trp Gln Ser Cys 
    370                 375                 380                 


Glu Ala Leu Arg Val Met Ala Lys Ile Met Arg Glu Cys Trp Tyr Ala 
385                 390                 395                 400 


Asn Gly Ala Ala Arg Leu Thr Ala Leu Arg Ile Lys Lys Thr Leu Ser 
                405                 410                 415     


Gln Leu Ser Gln Gln Glu Gly Ile Lys Met 
            420                 425     


<210>  32
<211>  5766
<212>  DNA
<213>  homo sapiens

<400>  32
gcggcggcta gggaggtggg gcgaggcgag gtttgctggg gtgaggcagc ggcgcggccg       60

ggccgggccg ggccacaggc ggtggcggcg ggaccatgga ggcggcggtc gctgctccgc      120

gtccccggct gctcctcctc gtgctggcgg cggcggcggc ggcggcggcg gcgctgctcc      180

cgggggcgac ggcgttacag tgtttctgcc acctctgtac aaaagacaat tttacttgtg      240

tgacagatgg gctctgcttt gtctctgtca cagagaccac agacaaagtt atacacaaca      300

gcatgtgtat agctgaaatt gacttaattc ctcgagatag gccgtttgta tgtgcaccct      360

cttcaaaaac tgggtctgtg actacaacat attgctgcaa tcaggaccat tgcaataaaa      420

tagaacttcc aactactggt ttaccattgc ttgttcagag aacaattgcg agaactattg      480

tgttacaaga aagcattggc aaaggtcgat ttggagaagt ttggagagga aagtggcggg      540

gagaagaagt tgctgttaag atattctcct ctagagaaga acgttcgtgg ttccgtgagg      600

cagagattta tcaaactgta atgttacgtc atgaaaacat cctgggattt atagcagcag      660

acaataaaga caatggtact tggactcagc tctggttggt gtcagattat catgagcatg      720

gatccctttt tgattactta aacagataca cagttactgt ggaaggaatg ataaaacttg      780

ctctgtccac ggcgagcggt cttgcccatc ttcacatgga gattgttggt acccaaggaa      840

agccagccat tgctcataga gatttgaaat caaagaatat cttggtaaag aagaatggaa      900

cttgctgtat tgcagactta ggactggcag taagacatga ttcagccaca gataccattg      960

atattgctcc aaaccacaga gtgggaacaa aaaggtacat ggcccctgaa gttctcgatg     1020

attccataaa tatgaaacat tttgaatcct tcaaacgtgc tgacatctat gcaatgggct     1080

tagtattctg ggaaattgct cgacgatgtt ccattggtgg aattcatgaa gattaccaac     1140

tgccttatta tgatcttgta ccttctgacc catcagttga agaaatgaga aaagttgttt     1200

gtgaacagaa gttaaggcca aatatcccaa acagatggca gagctgtgaa gccttgagag     1260

taatggctaa aattatgaga gaatgttggt atgccaatgg agcagctagg cttacagcat     1320

tgcggattaa gaaaacatta tcgcaactca gtcaacagga aggcatcaaa atgtaattct     1380

acagctttgc ctgaactctc cttttttctt cagatctgct cctgggtttt aatttgggag     1440

gtcaattgtt ctacctcact gagagggaac agaaggatat tgcttccttt tgcagcagtg     1500

taataaagtc aattaaaaac ttcccaggat ttctttggac ccaggaaaca gccatgtggg     1560

tcctttctgt gcactatgaa cgcttctttc ccaggacaga aaatgtgtag tctaccttta     1620

ttttttatta acaaaacttg ttttttaaaa agatgattgc tggtcttaac tttaggtaac     1680

tctgctgtgc tggagatcat ctttaagggc aaaggagttg gattgctgaa ttacaatgaa     1740

acatgtctta ttactaaaga aagtgattta ctcctggtta gtacattctc agaggattct     1800

gaaccactag agtttccttg attcagactt tgaatgtact gttctatagt ttttcaggat     1860

cttaaaacta acacttataa aactcttatc ttgagtctaa aaatgacctc atatagtagt     1920

gaggaacata attcatgcaa ttgtattttg tatactatta ttgttctttc acttattcag     1980

aacattacat gccttcaaaa tgggattgta ctataccagt aagtgccact tctgtgtctt     2040

tctaatggaa atgagtagaa ttgctgaaag tctctatgtt aaaacctata gtgtttgaat     2100

tcaaaaagct tatttatctg ggtaacccaa actttttctg ttttgttttt ggaagggttt     2160

ttgtggtatg tcatttggta ttctattctg aaaatgcctt tctcctacca aaatgtgctt     2220

aagccactaa agaaatgaag tggcattaat tagtaaatta ttagcatggt catgtttgaa     2280

tattctcaca tcaagctttt gcattttaat tgtgttgtct aagtatactt ttaaaaaatc     2340

aagtggcact ctagatgctt atagtacttt aatatttgta gcatacagac taatttttct     2400

aaaagggaaa gtctgtctag ctgcttgtga aaagttatgt ggtattctgt aagccatttt     2460

tttctttatc tgttcaaaga cttatttttt aagacatgaa ttacatttaa aattagaata     2520

tggttaatat taaataatag gcctttttct aggaaggcga aggtagttaa taatttgaat     2580

agataacaga tgtgcaagaa agtcacattt gttatgtatg taggagtaaa cgttcggtgg     2640

atcctctgtc tttgtaactg aggttagagc tagtgtggtt ttgaggtctc actacacttt     2700

gaggaaggca gcttttaatt cagtgtttcc ttatgtgtgc gtacattgca actgcttaca     2760

tgtaatttat gtaatgcatt cagtgcaccc ttgttacttg ggagaggtgg tagctaaaga     2820

acattctgag tataggtttt tctccattta cagatgtctt tggtcaaata ttgaaagcaa     2880

acttgtcatg gtcttcttac attaagttga aactagctta taataactgg tttttacttc     2940

caatgctatg aagtctctgc agggctttta cagttttcga agtcctttta tcactgtgat     3000

cttattctga ggggagaaaa aactatcata gctctgaggc aagacttcga ctttatagtg     3060

ctatcagttc cccgatacag ggtcagagta acccatacag tattttggtc aggaagagaa     3120

agtggccatt tacactgaat gagttgcatt ctgataatgt cttatctctt atacgtagaa     3180

taaatttgaa agactatttg atcttaaaac caaagtaatt ttagaatgag tgacatatta     3240

cataggaatt tagtgtcaat ttcatgtgtt taaaaacatc atgggaaaaa tgcttagagg     3300

ttactatttt gactacaaag ttgagttttt ttctgtagtt accataattt cattgaagca     3360

aatgaatgag tttgagaggt ttgtttttat agttgtgttg tattacttgt ttaataataa     3420

tctctaattc tgtgatcagg tacttttttt gtgggggttt tttttttgtt tttttttttt     3480

tttgttgttg tttttgggcc atttctaagc ctaccagatc tgctttatga aatccagggg     3540

accaatgcat tttatcacta aaactatttt tatataattt taagaatata ccaaaagttg     3600

tctgatttaa agttgtaata catgatttct cactttcatg taaggttatc cacttttgct     3660

gaagatattt tttattgaat caaagattga gttacaatta tacttttctt acctaagtgg     3720

ataaaatgta cttttgatga atcagggaat ttttttaaag ttggagttta gttctaaatt     3780

gactttacgt attactgcag ttaattcctt ttttggctag ggatggtttg ataaaccaca     3840

attggctgat attgaaaatg aaagaaactt aaaaggtggg atggatcatg attactgtcg     3900

ataactgcag ataaatttga ttagagtaat aattttgtca tttaaaaaca cagttgttta     3960

tactgcccat cctaggatgc tcaccttcca agattcaacg tggctaaaac atcttctggt     4020

aaattgtgcg tccatattca ttttgtcagt agccaggaga aatggggatg ggggaaatac     4080

gacttagtga ggcatagaca tccctggtcc atcctttctg tctccagctg tttcttggaa     4140

cctgctctcc tgcttgctgg tccctgacgc agagaccgtt gcctccccca cagccgtttg     4200

actgaaggct gctctggaga cctagagtaa aacggctgat ggaagttgtg ggacccactt     4260

ccatttcctt cagtcattag aggtggaagg gaggggtctc caagtttgga gattgagcag     4320

atgaggcttg ggatgcccct gctttgactt cagccatgga tgaggagtgg gatggcagca     4380

aggtggctcc tgtggcagtg gagttgtgcc agaaacagtg gccagttgta tcgcctataa     4440

gacagggtaa ggtctgaaga gctgagcctg taattctgct gtaataatga tagtgctcaa     4500

gaagtgcctt gagttggtgt acagtgccat ggccatcaag aatcccagat ttcaggtttt     4560

attacaaaat gtaagtggtc acttggcgat tttgtagtac atgcatgagt tacctttttt     4620

ctctatgtct gagaactgtc agattaaaac aagatggcaa agagatcgtt agagtgcaca     4680

acaaaatcac tatcccatta gacacatcat caaaagctta tttttattct tgcactggaa     4740

gaatcgtaag tcaactgttt cttgaccatg gcagtgttct ggctccaaat ggtagtgatt     4800

ccaaataatg gttctgttaa cactttggca gaaaatgcca gctcagatat tttgagatac     4860

taaggattat ctttggacat gtactgcagc ttcttgtctc tgttttggat tactggaata     4920

cccatgggcc ctctcaagag tgctggactt ctaggacatt aagatgattg tcagtacatt     4980

aaacttttca atcccattat gcaatcttgt ttgtaaatgt aaacttctaa aaatatggtt     5040

aataacattc aacctgttta ttacaactta aaaggaactt cagtgaattt gtttttattt     5100

tttaacaaga tttgtgaact gaatatcatg aaccatgttt tgatacccct ttttcacgtt     5160

gtgccaacgg aatagggtgt ttgatatttc ttcatatgtt aaggagatgc ttcaaaatgt     5220

caattgcttt aaacttaaat tacctctcaa gagaccaagg tacatttacc tcattgtgta     5280

tataatgttt aatatttgtc agagcattct ccaggtttgc agttttattt ctataaagta     5340

tgggtattat gttgctcagt tactcaaatg gtactgtatt gtttatattt gtaccccaaa     5400

taacatcgtc tgtactttct gttttctgta ttgtatttgt gcaggattct ttaggcttta     5460

tcagtgtaat ttctgccttt taagatatgt acagaaaatg tccatataaa tttccattga     5520

agtcgaatga tactgagaag cctgtaaaga ggagaaaaaa cataagctgt gtttccccat     5580

aagttttttt aaattgtata ttgtatttgt agtaatattc caaaagaatg taaataggaa     5640

atagaagagt gatgcttatg ttaagtccta acactacagt agaagaatgg aagcagtgca     5700

aataaattac atttttccca aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa gaaaaaaaaa     5760

aaaaaa                                                                5766


<210>  33
<211>  567
<212>  PRT
<213>  homo sapiens

<400>  33

Met Gly Arg Gly Leu Leu Arg Gly Leu Trp Pro Leu His Ile Val Leu 
1               5                   10                  15      


Trp Thr Arg Ile Ala Ser Thr Ile Pro Pro His Val Gln Lys Ser Val 
            20                  25                  30          


Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro 
        35                  40                  45              


Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln 
    50                  55                  60                  


Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro 
65                  70                  75                  80  


Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr 
                85                  90                  95      


Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile 
            100                 105                 110         


Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys 
        115                 120                 125             


Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn 
    130                 135                 140                 


Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu 
145                 150                 155                 160 


Leu Leu Val Ile Phe Gln Val Thr Gly Ile Ser Leu Leu Pro Pro Leu 
                165                 170                 175     


Gly Val Ala Ile Ser Val Ile Ile Ile Phe Tyr Cys Tyr Arg Val Asn 
            180                 185                 190         


Arg Gln Gln Lys Leu Ser Ser Thr Trp Glu Thr Gly Lys Thr Arg Lys 
        195                 200                 205             


Leu Met Glu Phe Ser Glu His Cys Ala Ile Ile Leu Glu Asp Asp Arg 
    210                 215                 220                 


Ser Asp Ile Ser Ser Thr Cys Ala Asn Asn Ile Asn His Asn Thr Glu 
225                 230                 235                 240 


Leu Leu Pro Ile Glu Leu Asp Thr Leu Val Gly Lys Gly Arg Phe Ala 
                245                 250                 255     


Glu Val Tyr Lys Ala Lys Leu Lys Gln Asn Thr Ser Glu Gln Phe Glu 
            260                 265                 270         


Thr Val Ala Val Lys Ile Phe Pro Tyr Glu Glu Tyr Ala Ser Trp Lys 
        275                 280                 285             


Thr Glu Lys Asp Ile Phe Ser Asp Ile Asn Leu Lys His Glu Asn Ile 
    290                 295                 300                 


Leu Gln Phe Leu Thr Ala Glu Glu Arg Lys Thr Glu Leu Gly Lys Gln 
305                 310                 315                 320 


Tyr Trp Leu Ile Thr Ala Phe His Ala Lys Gly Asn Leu Gln Glu Tyr 
                325                 330                 335     


Leu Thr Arg His Val Ile Ser Trp Glu Asp Leu Arg Lys Leu Gly Ser 
            340                 345                 350         


Ser Leu Ala Arg Gly Ile Ala His Leu His Ser Asp His Thr Pro Cys 
        355                 360                 365             


Gly Arg Pro Lys Met Pro Ile Val His Arg Asp Leu Lys Ser Ser Asn 
    370                 375                 380                 


Ile Leu Val Lys Asn Asp Leu Thr Cys Cys Leu Cys Asp Phe Gly Leu 
385                 390                 395                 400 


Ser Leu Arg Leu Asp Pro Thr Leu Ser Val Asp Asp Leu Ala Asn Ser 
                405                 410                 415     


Gly Gln Val Gly Thr Ala Arg Tyr Met Ala Pro Glu Val Leu Glu Ser 
            420                 425                 430         


Arg Met Asn Leu Glu Asn Val Glu Ser Phe Lys Gln Thr Asp Val Tyr 
        435                 440                 445             


Ser Met Ala Leu Val Leu Trp Glu Met Thr Ser Arg Cys Asn Ala Val 
    450                 455                 460                 


Gly Glu Val Lys Asp Tyr Glu Pro Pro Phe Gly Ser Lys Val Arg Glu 
465                 470                 475                 480 


His Pro Cys Val Glu Ser Met Lys Asp Asn Val Leu Arg Asp Arg Gly 
                485                 490                 495     


Arg Pro Glu Ile Pro Ser Phe Trp Leu Asn His Gln Gly Ile Gln Met 
            500                 505                 510         


Val Cys Glu Thr Leu Thr Glu Cys Trp Asp His Asp Pro Glu Ala Arg 
        515                 520                 525             


Leu Thr Ala Gln Cys Val Ala Glu Arg Phe Ser Glu Leu Glu His Leu 
    530                 535                 540                 


Asp Arg Leu Ser Gly Arg Ser Cys Ser Glu Glu Lys Ile Pro Glu Asp 
545                 550                 555                 560 


Gly Ser Leu Asn Thr Thr Lys 
                565         


<210>  34
<211>  487
<212>  DNA
<213>  homo sapiens

<400>  34
cctcctggct ggcgagcggg cgccacatct ggcccgcaca tctgcgctgc cggcccggcg       60

cggggtccgg agagggcgcg gcgcggaggc gcagccaggg gtccgggaag gcgccgtccg      120

ctgcgctggg ggctcggtct atgacgagca gcggggtctg ccatgggtcg ggggctgctc      180

aggggcctgt ggccgctgca catcgtcctg tggacgcgta tcgccagcac gatcccaccg      240

cacgttcaga agtcgggtga gtggtcccca gcccgggctc ggcggggcgc cgggggtctt      300

cctggggtcc ccgcctctcc gctgcgcttg acagtcgggc ccggcaaccc ggcccccggg      360

cggaaacgag gaaagtttcc cccgcgacac tcacgcagcc cgactcccgt agctgcaggg      420

attgtgagtt tttcttgaaa aagagaagga aagttcagtt gcaaggggcg cggggcacgt      480

ttggtcc                                                                487


<210>  35
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  siRNA sequence for Tgfbr1 sense strand

<400>  35
ugucaaggag augcuucaau att                                               23


<210>  36
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  siRNA sequence for Tgfbr1 antisense strand

<400>  36
uauugaagca ucuccuugac auatt                                             25


<210>  37
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  siRNA sequence for Tgfbr2 sense strand

<400>  37
ggcucgcuga acacuaccaa att                                               23


<210>  38
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  siRNA sequence for Tgfbr2 antisense strand

<400>  38
uuugguagug uucagcgagc cautt                                             25


