                         SEQUENCE LISTING

<110>  OXFORD UNIVERSITY INNOVATION LIMITED
 
<120>  HCV VACCINES

<130>  JDM81169P.WOP

<150>  GB 1605099.9
<151>  2016-03-24

<160>  195   

<170>  PatentIn version 3.5

<210>  1
<211>  191
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Ala Arg Arg Pro Glu Gly Arg Thr Trp Ala Gln Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Thr Asp Pro 
            100                 105                 110         


Arg Arg Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Ala Pro Leu 
    130                 135                 140                 


Gly Gly Ala Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Leu Thr Val Pro Ala Ser Ala 
            180                 185                 190     


<210>  2
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  2

Tyr Val Gly Asp Leu Cys Gly Ser Val Phe Leu Val Ser Gln Leu Phe 
1               5                   10                  15      


Thr Phe Ser Pro Arg 
            20      


<210>  3
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  3

Tyr Pro Gly His Ile Thr Gly His Arg Met Ala Trp Asp Met Met Met 
1               5                   10                  15      


Asn Trp Ser Pro 
            20  


<210>  4
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  4

Val Cys Gly Pro Val Tyr Cys Phe Thr Pro Ser Pro Val Val Val Gly 
1               5                   10                  15      


Thr Thr Asp Arg 
            20  


<210>  5
<211>  22
<212>  PRT
<213>  Homo sapiens

<400>  5

Thr Asp Val Phe Leu Leu Asn Asn Thr Arg Pro Pro Leu Gly Asn Trp 
1               5                   10                  15      


Phe Gly Cys Thr Trp Met 
            20          


<210>  6
<211>  36
<212>  PRT
<213>  Homo sapiens

<400>  6

Cys Pro Thr Asp Cys Phe Arg Lys His Pro Glu Ala Thr Tyr Ser Arg 
1               5                   10                  15      


Cys Gly Ser Gly Pro Trp Leu Thr Pro Arg Cys Leu Val Asp Tyr Pro 
            20                  25                  30          


Tyr Arg Leu Trp 
        35      


<210>  7
<211>  54
<212>  PRT
<213>  Homo sapiens

<400>  7

Asp Arg Asp Arg Ser Glu Leu Ser Pro Leu Leu Leu Ser Thr Thr Glu 
1               5                   10                  15      


Trp Gln Val Leu Pro Cys Ser Phe Thr Thr Leu Pro Ala Leu Ser Thr 
            20                  25                  30          


Gly Leu Ile His Leu His Gln Asn Ile Val Asp Val Gln Tyr Leu Tyr 
        35                  40                  45              


Gly Val Gly Ser Ser Val 
    50                  


<210>  8
<211>  54
<212>  PRT
<213>  Homo sapiens

<400>  8

Asp Arg Asp Arg Ser Glu Leu Ser Pro Leu Leu Leu Ser Thr Thr Gln 
1               5                   10                  15      


Trp Gln Val Leu Pro Cys Ser Phe Thr Thr Leu Pro Ala Leu Ser Thr 
            20                  25                  30          


Gly Leu Ile His Leu His Gln Asn Ile Val Asp Val Gln Tyr Leu Tyr 
        35                  40                  45              


Gly Val Gly Ser Ser Val 
    50                  


<210>  9
<211>  24
<212>  PRT
<213>  Homo sapiens

<400>  9

Ala Arg Val Cys Ala Cys Leu Trp Met Met Leu Leu Ile Ala Gln Ala 
1               5                   10                  15      


Glu Ala Ala Leu Glu Asn Leu Val 
            20                  


<210>  10
<211>  44
<212>  PRT
<213>  Homo sapiens

<400>  10

Gln Gly Trp Arg Leu Leu Ala Pro Ile Thr Ala Tyr Ala Gln Gln Thr 
1               5                   10                  15      


Arg Gly Leu Leu Gly Cys Ile Ile Thr Ser Leu Thr Gly Arg Asp Lys 
            20                  25                  30          


Asn Gln Val Glu Gly Glu Val Gln Ile Val Ser Thr 
        35                  40                  


<210>  11
<211>  44
<212>  PRT
<213>  Homo sapiens

<400>  11

Lys Gly Trp Arg Leu Leu Ala Pro Ile Thr Ala Tyr Ala Gln Gln Thr 
1               5                   10                  15      


Arg Gly Leu Leu Gly Cys Ile Ile Thr Ser Leu Thr Gly Arg Asp Lys 
            20                  25                  30          


Asn Gln Val Glu Gly Glu Val Gln Ile Val Ser Thr 
        35                  40                  


<210>  12
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  12

Gln Ser Phe Leu Ala Thr Cys Ile Asn Gly Val Cys Trp Thr Val Tyr 
1               5                   10                  15      


His Gly Ala Gly 
            20  


<210>  13
<211>  153
<212>  PRT
<213>  Homo sapiens

<400>  13

Pro Cys Thr Cys Gly Ser Ser Asp Leu Tyr Leu Val Thr Arg His Ala 
1               5                   10                  15      


Asp Val Ile Pro Val Arg Arg Arg Gly Asp Ser Arg Gly Ser Leu Leu 
            20                  25                  30          


Ser Pro Arg Pro Ile Ser Tyr Leu Lys Gly Ser Ser Gly Gly Pro Leu 
        35                  40                  45              


Leu Cys Pro Ser Gly His Ala Val Gly Ile Phe Arg Ala Ala Val Cys 
    50                  55                  60                  


Thr Arg Gly Val Ala Lys Ala Val Asp Phe Ile Pro Val Glu Ser Leu 
65                  70                  75                  80  


Glu Thr Thr Met Arg Ser Pro Val Phe Thr Asp Asn Ser Ser Pro Pro 
                85                  90                  95      


Ala Val Pro Gln Thr Phe Gln Val Ala His Leu His Ala Pro Thr Gly 
            100                 105                 110         


Ser Gly Lys Ser Thr Lys Val Pro Ala Ala Tyr Ala Ala Gln Gly Tyr 
        115                 120                 125             


Lys Val Leu Val Leu Asn Pro Ser Val Ala Ala Thr Leu Gly Phe Gly 
    130                 135                 140                 


Ala Tyr Met Ser Lys Ala His Gly Val 
145                 150             


<210>  14
<211>  153
<212>  PRT
<213>  Homo sapiens

<400>  14

Pro Cys Thr Cys Gly Ser Ser Asp Leu Tyr Leu Val Thr Arg His Ala 
1               5                   10                  15      


Asp Val Ile Pro Val Arg Arg Arg Gly Asp Ser Arg Gly Ser Leu Leu 
            20                  25                  30          


Ser Pro Arg Pro Ile Ser Tyr Leu Lys Gly Ser Ser Gly Gly Pro Leu 
        35                  40                  45              


Leu Cys Pro Ser Gly His Ala Val Gly Ile Phe Arg Ala Ala Val Cys 
    50                  55                  60                  


Thr Arg Gly Val Ala Lys Ala Val Asp Phe Ile Pro Val Glu Ser Met 
65                  70                  75                  80  


Glu Thr Thr Met Arg Ser Pro Val Phe Thr Asp Asn Ser Ser Pro Pro 
                85                  90                  95      


Ala Val Pro Gln Thr Phe Gln Val Ala His Leu His Ala Pro Thr Gly 
            100                 105                 110         


Ser Gly Lys Ser Thr Lys Val Pro Ala Ala Tyr Ala Ala Gln Gly Tyr 
        115                 120                 125             


Lys Val Leu Val Leu Asn Pro Ser Val Ala Ala Thr Leu Gly Phe Gly 
    130                 135                 140                 


Ala Tyr Met Ser Lys Ala His Gly Val 
145                 150             


<210>  15
<211>  86
<212>  PRT
<213>  Homo sapiens

<400>  15

Thr Gly Val Arg Thr Ile Thr Thr Gly Ala Pro Ile Thr Tyr Ser Thr 
1               5                   10                  15      


Tyr Gly Lys Phe Leu Ala Asp Gly Gly Cys Ser Gly Gly Ala Tyr Asp 
            20                  25                  30          


Ile Ile Ile Cys Asp Glu Cys His Ser Thr Asp Ala Thr Ser Ile Leu 
        35                  40                  45              


Gly Ile Gly Thr Val Leu Asp Gln Ala Glu Thr Ala Gly Ala Arg Leu 
    50                  55                  60                  


Val Val Leu Ala Thr Ala Thr Pro Pro Gly Ser Val Thr Val Pro His 
65                  70                  75                  80  


Pro Asn Ile Glu Glu Val 
                85      


<210>  16
<211>  86
<212>  PRT
<213>  Homo sapiens

<400>  16

Thr Gly Val Arg Thr Ile Thr Thr Gly Ser Pro Ile Thr Tyr Ser Thr 
1               5                   10                  15      


Tyr Gly Lys Phe Leu Ala Asp Gly Gly Cys Ser Gly Gly Ala Tyr Asp 
            20                  25                  30          


Ile Ile Ile Cys Asp Glu Cys His Ser Thr Asp Ala Thr Ser Ile Leu 
        35                  40                  45              


Gly Ile Gly Thr Val Leu Asp Gln Ala Glu Thr Ala Gly Ala Arg Leu 
    50                  55                  60                  


Val Val Leu Ala Thr Ala Thr Pro Pro Gly Ser Val Thr Val Pro His 
65                  70                  75                  80  


Pro Asn Ile Glu Glu Val 
                85      


<210>  17
<211>  83
<212>  PRT
<213>  Homo sapiens

<400>  17

Asn Ala Val Ala Tyr Tyr Arg Gly Leu Asp Val Ser Val Ile Pro Thr 
1               5                   10                  15      


Ser Gly Asp Val Val Val Val Ala Thr Asp Ala Leu Met Thr Gly Phe 
            20                  25                  30          


Thr Gly Asp Phe Asp Ser Val Ile Asp Cys Asn Thr Cys Val Thr Gln 
        35                  40                  45              


Thr Val Asp Phe Ser Leu Asp Pro Thr Phe Thr Ile Glu Thr Thr Thr 
    50                  55                  60                  


Leu Pro Gln Asp Ala Val Ser Arg Thr Gln Arg Arg Gly Arg Thr Gly 
65                  70                  75                  80  


Arg Gly Arg 
            


<210>  18
<211>  118
<212>  PRT
<213>  Homo sapiens

<400>  18

Tyr Arg Phe Val Thr Pro Gly Glu Arg Pro Ser Gly Met Phe Asp Ser 
1               5                   10                  15      


Ser Val Leu Cys Glu Cys Tyr Asp Ala Gly Cys Ala Trp Tyr Glu Leu 
            20                  25                  30          


Thr Pro Ala Glu Thr Thr Val Arg Leu Arg Ala Tyr Leu Asn Thr Pro 
        35                  40                  45              


Gly Leu Pro Val Cys Gln Asp His Leu Glu Phe Trp Glu Gly Val Phe 
    50                  55                  60                  


Thr Gly Leu Thr His Ile Asp Ala His Phe Leu Ser Gln Thr Lys Gln 
65                  70                  75                  80  


Ala Gly Glu Asn Phe Pro Tyr Leu Val Ala Tyr Gln Ala Thr Val Cys 
                85                  90                  95      


Ala Arg Ala Gln Ala Pro Pro Pro Ser Trp Asp Gln Met Trp Lys Cys 
            100                 105                 110         


Leu Ile Arg Leu Lys Pro 
        115             


<210>  19
<211>  118
<212>  PRT
<213>  Homo sapiens

<400>  19

Tyr Arg Phe Val Thr Pro Gly Glu Arg Pro Ser Gly Met Phe Asp Ser 
1               5                   10                  15      


Ser Val Leu Cys Glu Cys Tyr Asp Ala Gly Cys Ala Trp Tyr Glu Leu 
            20                  25                  30          


Thr Pro Ala Glu Thr Thr Val Arg Leu Arg Ala Tyr Leu Asn Thr Pro 
        35                  40                  45              


Gly Leu Pro Val Cys Gln Asp His Leu Glu Phe Trp Glu Gly Val Phe 
    50                  55                  60                  


Thr Gly Leu Thr His Ile Asp Ala His Phe Leu Ser Gln Thr Lys Gln 
65                  70                  75                  80  


Ala Gly Asp Asn Phe Pro Tyr Leu Val Ala Tyr Gln Ala Thr Val Cys 
                85                  90                  95      


Ala Arg Ala Gln Ala Pro Pro Pro Ser Trp Asp Gln Met Trp Lys Cys 
            100                 105                 110         


Leu Ile Arg Leu Lys Pro 
        115             


<210>  20
<211>  48
<212>  PRT
<213>  Homo sapiens

<400>  20

Lys Tyr Ile Met Thr Cys Met Ser Ala Asp Leu Glu Val Val Thr Ser 
1               5                   10                  15      


Thr Trp Val Leu Val Gly Gly Val Leu Ala Ala Leu Ala Ala Tyr Cys 
            20                  25                  30          


Leu Ser Thr Gly Cys Val Val Ile Val Gly Arg Ile Val Leu Ser Gly 
        35                  40                  45              


<210>  21
<211>  45
<212>  PRT
<213>  Homo sapiens

<400>  21

Phe Trp Ala Lys His Met Trp Asn Phe Ile Ser Gly Ile Gln Tyr Leu 
1               5                   10                  15      


Ala Gly Leu Ser Thr Leu Pro Gly Asn Pro Ala Ile Ala Ser Leu Met 
            20                  25                  30          


Ala Phe Thr Ala Ala Val Thr Ser Pro Leu Thr Thr Gln 
        35                  40                  45  


<210>  22
<211>  45
<212>  PRT
<213>  Homo sapiens

<400>  22

Phe Trp Ala Lys His Met Trp Asn Phe Ile Ser Gly Ile Gln Tyr Leu 
1               5                   10                  15      


Ala Gly Leu Ser Thr Leu Pro Gly Asn Pro Ala Ile Ala Ser Leu Met 
            20                  25                  30          


Ala Phe Thr Ala Ser Val Thr Ser Pro Leu Thr Thr Gln 
        35                  40                  45  


<210>  23
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  23

Gly Ser Ile Gly Leu Gly Lys Val Leu Val Asp Ile Leu Ala Gly Tyr 
1               5                   10                  15      


Gly Ala Gly Val Ala Gly Ala Leu Val Ala Phe Lys Ile Met Ser Gly 
            20                  25                  30          


Glu Val Pro Ser Thr Glu Asp Leu Val Asn Leu Leu Pro Ala Ile Leu 
        35                  40                  45              


Ser Pro Gly Ala Leu Val Val Gly Val Val Cys Ala Ala Ile Leu Arg 
    50                  55                  60                  


Arg His Val Gly Pro Gly Glu Gly Ala Val Gln Trp Met Asn Arg Leu 
65                  70                  75                  80  


Ile Ala Phe Ala Ser Arg Gly Asn His Val Ser Pro Thr His Tyr Val 
                85                  90                  95      


Pro Glu Ser Asp Ala Ala Ala Arg Val Thr Gln Ile Leu Ser 
            100                 105                 110 


<210>  24
<211>  22
<212>  PRT
<213>  Homo sapiens

<400>  24

Ser Trp Leu Arg Asp Ile Trp Asp Trp Ile Cys Glu Val Leu Ser Asp 
1               5                   10                  15      


Phe Lys Thr Trp Leu Lys 
            20          


<210>  25
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  25

Cys Pro Cys Gln Val Pro Ser Pro Glu Phe Phe Thr Glu Leu Asp Gly 
1               5                   10                  15      


Val Arg Leu His Arg 
            20      


<210>  26
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  26

Arg Arg Leu Ala Arg Gly Ser Pro Pro Ser Leu Ala Ser Ser Ser Ala 
1               5                   10                  15      


Ser Gln Leu Ser Ala Pro Ser Leu Lys Ala Thr Cys Thr Thr Asn His 
            20                  25                  30          


<210>  27
<211>  33
<212>  PRT
<213>  Homo sapiens

<400>  27

Ser Asp Ala Glu Ser Tyr Ser Ser Met Pro Pro Leu Glu Gly Glu Pro 
1               5                   10                  15      


Gly Asp Pro Asp Leu Ser Asp Gly Ser Trp Ser Thr Val Ser Ser Glu 
            20                  25                  30          


Glu 
    


<210>  28
<211>  33
<212>  PRT
<213>  Homo sapiens

<400>  28

Ser Asp Ala Glu Ser Tyr Ser Ser Met Pro Pro Leu Glu Gly Glu Pro 
1               5                   10                  15      


Gly Asp Pro Asp Leu Ser Asp Gly Ser Trp Ser Thr Val Ser Ser Glu 
            20                  25                  30          


Ala 
    


<210>  29
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  29

Leu Ser Asn Ser Leu Leu Arg His His Asn Met Val Tyr Ala Thr Thr 
1               5                   10                  15      


Ser Arg Ser Ala 
            20  


<210>  30
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  30

Leu Thr Pro Pro His Ser Ala Lys Ser Lys Phe Gly Tyr Gly Ala Lys 
1               5                   10                  15      


Asp Val Arg Cys His 
            20      


<210>  31
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  31

Lys Pro Ala Arg Leu Ile Val Phe Pro Asp Leu Gly Val Arg Val Cys 
1               5                   10                  15      


Glu Lys Met Ala Leu Tyr Asp Val Val 
            20                  25  


<210>  32
<211>  23
<212>  PRT
<213>  Homo sapiens

<400>  32

Pro Met Gly Phe Ser Tyr Asp Thr Arg Cys Phe Asp Ser Thr Val Thr 
1               5                   10                  15      


Glu Ser Asp Ile Arg Thr Glu 
            20              


<210>  33
<211>  54
<212>  PRT
<213>  Homo sapiens

<400>  33

Ser Leu Thr Glu Arg Leu Tyr Val Gly Gly Pro Leu Thr Asn Ser Lys 
1               5                   10                  15      


Gly Gln Asn Cys Gly Tyr Arg Arg Cys Arg Ala Ser Gly Val Leu Thr 
            20                  25                  30          


Thr Ser Cys Gly Asn Thr Leu Thr Cys Tyr Leu Lys Ala Ser Ala Ala 
        35                  40                  45              


Cys Arg Ala Ala Lys Leu 
    50                  


<210>  34
<211>  23
<212>  PRT
<213>  Homo sapiens

<400>  34

Cys Thr Met Leu Val Cys Gly Asp Asp Leu Val Val Ile Cys Glu Ser 
1               5                   10                  15      


Ala Gly Thr Gln Glu Asp Ala 
            20              


<210>  35
<211>  91
<212>  PRT
<213>  Homo sapiens

<400>  35

Ser Leu Arg Ala Phe Thr Glu Ala Met Thr Arg Tyr Ser Ala Pro Pro 
1               5                   10                  15      


Gly Asp Pro Pro Gln Pro Glu Tyr Asp Leu Glu Leu Ile Thr Ser Cys 
            20                  25                  30          


Ser Ser Asn Val Ser Val Ala His Asp Ala Ser Gly Lys Arg Val Tyr 
        35                  40                  45              


Tyr Leu Thr Arg Asp Pro Thr Thr Pro Leu Ala Arg Ala Ala Trp Glu 
    50                  55                  60                  


Thr Ala Arg His Thr Pro Val Asn Ser Trp Leu Gly Asn Ile Ile Met 
65                  70                  75                  80  


Phe Ala Pro Thr Leu Trp Ala Arg Met Ile Leu 
                85                  90      


<210>  36
<211>  91
<212>  PRT
<213>  Homo sapiens

<400>  36

Ser Leu Arg Ala Phe Thr Glu Ala Met Thr Arg Tyr Ser Ala Pro Pro 
1               5                   10                  15      


Gly Asp Pro Pro Gln Pro Glu Tyr Asp Leu Glu Leu Ile Thr Ser Cys 
            20                  25                  30          


Ser Ser Asn Val Ser Val Ala His Asp Ala Ser Gly Lys Arg Val Tyr 
        35                  40                  45              


Tyr Leu Thr Arg Asp Pro Thr Thr Pro Leu Ala Arg Ala Ala Trp Glu 
    50                  55                  60                  


Thr Ala Arg His Thr Pro Val Asn Ser Trp Leu Gly Asn Ile Ile Met 
65                  70                  75                  80  


Tyr Ala Pro Thr Leu Trp Ala Arg Met Ile Leu 
                85                  90      


<210>  37
<211>  55
<212>  PRT
<213>  Homo sapiens

<400>  37

Glu Pro Leu Asp Leu Pro Gln Ile Ile Gln Arg Leu His Gly Leu Ser 
1               5                   10                  15      


Ala Phe Ser Leu His Ser Tyr Ser Pro Gly Glu Ile Asn Arg Val Ala 
            20                  25                  30          


Ala Cys Leu Arg Lys Leu Gly Val Pro Pro Leu Arg Ala Trp Arg His 
        35                  40                  45              


Arg Ala Arg Ser Val Arg Ala 
    50                  55  


<210>  38
<211>  28
<212>  PRT
<213>  Homo sapiens

<400>  38

Gly Gly Arg Ala Ala Ile Cys Gly Lys Tyr Leu Phe Asn Trp Ala Val 
1               5                   10                  15      


Arg Thr Lys Leu Lys Leu Thr Pro Ile Pro Ala Ala 
            20                  25              


<210>  39
<211>  190
<212>  PRT
<213>  Homo sapiens

<400>  39

Met Ser Thr Leu Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Ala Arg Arg Pro Glu Gly Arg Ser Trp Ala Gln Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Asn Asp Pro 
            100                 105                 110         


Arg Arg Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Ala Pro Leu 
    130                 135                 140                 


Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Ala Leu Glu Asp 
145                 150                 155                 160 


Gly Val Asn Phe Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Leu Thr His Pro Ala Ser 
            180                 185                 190 


<210>  40
<211>  190
<212>  PRT
<213>  Homo sapiens

<400>  40

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Ala Arg Arg Pro Glu Gly Arg Ser Trp Ala Gln Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Thr Asp Pro 
            100                 105                 110         


Arg Arg Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Ala Pro Leu 
    130                 135                 140                 


Gly Gly Ala Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Leu Thr Val Pro Ala Ser 
            180                 185                 190 


<210>  41
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  41

Val Asp Leu Leu Val Gly Ala Ala Thr Met Cys Ser Ala Leu Tyr Val 
1               5                   10                  15      


Gly Asp Leu Cys Gly 
            20      


<210>  42
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  42

Val Asp Leu Leu Val Gly Ala Ala Thr Met Cys Ser Ala Leu Tyr Val 
1               5                   10                  15      


Gly Asp Leu Cys Gly 
            20      


<210>  43
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  43

His Trp Gly Val Leu Ala Gly Leu Ala Tyr Tyr Ser Met Gln Gly Asn 
1               5                   10                  15      


Trp Ala Lys Val 
            20  


<210>  44
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  44

Ser Val Cys Gly Pro Val Tyr Cys Phe Thr Pro Ser Pro Val Val Val 
1               5                   10                  15      


Gly Thr Thr Asp Arg 
            20      


<210>  45
<211>  26
<212>  PRT
<213>  Homo sapiens

<400>  45

Arg Cys Gly Ser Gly Pro Trp Leu Thr Pro Arg Cys Leu Val Asp Tyr 
1               5                   10                  15      


Pro Tyr Arg Leu Trp His Tyr Pro Cys Thr 
            20                  25      


<210>  46
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  46

Ala Ala Cys Asn Trp Thr Arg Gly Glu Arg Cys Asp Ile Glu Asp Arg 
1               5                   10                  15      


Asp Arg Ser Glu Leu 
            20      


<210>  47
<211>  41
<212>  PRT
<213>  Homo sapiens

<400>  47

Thr Thr Glu Leu Ala Ile Leu Pro Cys Ser Phe Thr Pro Leu Pro Ala 
1               5                   10                  15      


Leu Ser Thr Gly Leu Ile His Leu His Gln Asn Ile Val Asp Val Gln 
            20                  25                  30          


Tyr Leu Tyr Gly Val Gly Ser Gly Met 
        35                  40      


<210>  48
<211>  45
<212>  PRT
<213>  Homo sapiens

<400>  48

Met Gly Trp Arg Leu Leu Ala Pro Ile Thr Ala Tyr Ala Gln Gln Thr 
1               5                   10                  15      


Arg Gly Leu Leu Gly Cys Ile Val Thr Ser Leu Thr Gly Arg Asp Lys 
            20                  25                  30          


Asn Val Val Glu Gly Glu Val Gln Val Leu Ser Thr Ala 
        35                  40                  45  


<210>  49
<211>  45
<212>  PRT
<213>  Homo sapiens

<400>  49

Met Gly Trp Arg Leu Leu Ala Pro Ile Thr Ala Tyr Ala Gln Gln Thr 
1               5                   10                  15      


Arg Gly Leu Leu Gly Thr Ile Val Thr Ser Leu Thr Gly Arg Asp Lys 
            20                  25                  30          


Asn Val Val Thr Gly Glu Val Gln Val Leu Ser Thr Ala 
        35                  40                  45  


<210>  50
<211>  80
<212>  PRT
<213>  Homo sapiens

<400>  50

Pro Cys Thr Cys Gly Ser Ser Asp Leu Tyr Leu Val Thr Arg His Ala 
1               5                   10                  15      


Asp Val Ile Pro Ala Arg Arg Arg Gly Asp Ser Arg Ala Ser Leu Leu 
            20                  25                  30          


Ser Pro Arg Pro Leu Ala Tyr Leu Lys Gly Ser Ser Gly Gly Pro Leu 
        35                  40                  45              


Leu Cys Pro Ser Gly His Val Ala Gly Ile Phe Arg Ala Ala Val Cys 
    50                  55                  60                  


Thr Arg Gly Val Ala Lys Ala Leu Gln Phe Ile Pro Val Glu Thr Leu 
65                  70                  75                  80  


<210>  51
<211>  80
<212>  PRT
<213>  Homo sapiens

<400>  51

Pro Cys Thr Cys Gly Ser Ala Asp Leu Tyr Leu Val Thr Arg Asp Ala 
1               5                   10                  15      


Asp Val Ile Pro Ala Arg Arg Arg Gly Asp Ser Thr Ala Ser Leu Leu 
            20                  25                  30          


Ser Pro Arg Pro Leu Ala Cys Leu Lys Gly Ser Ser Gly Gly Pro Val 
        35                  40                  45              


Met Cys Pro Ser Gly His Val Ala Gly Ile Phe Arg Ala Ala Val Cys 
    50                  55                  60                  


Thr Arg Gly Val Ala Lys Ala Leu Gln Phe Ile Pro Val Glu Thr Leu 
65                  70                  75                  80  


<210>  52
<211>  66
<212>  PRT
<213>  Homo sapiens

<400>  52

Arg Ser Pro Ser Phe Ser Asp Asn Ser Thr Pro Pro Ala Val Pro Gln 
1               5                   10                  15      


Ser Tyr Gln Val Ala His Leu His Ala Pro Thr Gly Ser Gly Lys Ser 
            20                  25                  30          


Thr Lys Val Pro Ala Ala Tyr Ala Ala Gln Gly Tyr Lys Val Leu Val 
        35                  40                  45              


Leu Asn Pro Ser Val Ala Ala Thr Leu Gly Phe Gly Ala Tyr Met Ser 
    50                  55                  60                  


Lys Ala 
65      


<210>  53
<211>  66
<212>  PRT
<213>  Homo sapiens

<400>  53

Arg Ser Pro Val Phe Ser Asp Asn Ser Ser Pro Pro Ala Val Pro Gln 
1               5                   10                  15      


Ser Tyr Gln Val Ala His Leu His Ala Pro Thr Gly Ser Gly Lys Ser 
            20                  25                  30          


Thr Lys Val Pro Ala Ala Tyr Ala Ala Gln Gly Tyr Lys Val Leu Val 
        35                  40                  45              


Leu Asn Pro Ser Val Ala Ala Thr Leu Gly Phe Gly Ala Tyr Met Ser 
    50                  55                  60                  


Lys Ala 
65      


<210>  54
<211>  88
<212>  PRT
<213>  Homo sapiens

<400>  54

Thr Gly Asn Arg Thr Ile Thr Thr Gly Ala Lys Ile Thr Tyr Ser Thr 
1               5                   10                  15      


Tyr Gly Lys Phe Leu Ala Asp Gly Gly Cys Ser Gly Gly Ala Tyr Asp 
            20                  25                  30          


Ile Ile Ile Cys Asp Glu Cys His Ser Gln Asp Ala Thr Ser Ile Leu 
        35                  40                  45              


Gly Ile Gly Thr Val Leu Asp Gln Ala Glu Thr Ala Gly Ala Arg Leu 
    50                  55                  60                  


Thr Val Leu Ala Thr Ala Thr Pro Pro Gly Ser Ile Thr Val Pro His 
65                  70                  75                  80  


Ser Asn Ile Glu Glu Val Ala Leu 
                85              


<210>  55
<211>  88
<212>  PRT
<213>  Homo sapiens

<400>  55

Thr Gly Asn Arg Thr Ile Thr Thr Gly Ala Lys Leu Thr Tyr Ser Thr 
1               5                   10                  15      


Tyr Gly Lys Phe Leu Ala Asp Gly Gly Cys Ser Gly Gly Ala Tyr Asp 
            20                  25                  30          


Val Ile Ile Cys Asp Glu Cys His Ala Gln Asp Ala Thr Ser Ile Leu 
        35                  40                  45              


Gly Ile Gly Thr Val Leu Asp Gln Ala Glu Thr Ala Gly Val Arg Leu 
    50                  55                  60                  


Thr Val Leu Ala Thr Ala Thr Pro Pro Gly Ser Ile Thr Val Pro His 
65                  70                  75                  80  


Ser Asn Ile Glu Glu Val Ala Leu 
                85              


<210>  56
<211>  210
<212>  PRT
<213>  Homo sapiens

<400>  56

Ser Val Ile Pro Thr Ser Gly Asp Val Val Val Cys Ala Thr Asp Ala 
1               5                   10                  15      


Leu Met Thr Gly Phe Thr Gly Asp Phe Asp Ser Val Ile Asp Cys Asn 
            20                  25                  30          


Thr Cys Val Glu Gln Thr Val Asp Phe Ser Leu Asp Pro Thr Phe Ser 
        35                  40                  45              


Ile Glu Thr Thr Thr Ala Pro Gln Asp Ala Val Ser Arg Ser Gln Arg 
    50                  55                  60                  


Arg Gly Arg Thr Gly Arg Gly Arg Leu Gly Thr Tyr Arg Phe Val Thr 
65                  70                  75                  80  


Pro Gly Glu Arg Pro Ser Gly Met Phe Asp Ser Val Val Leu Cys Glu 
                85                  90                  95      


Cys Tyr Asp Ala Gly Cys Ala Trp Tyr Glu Leu Gln Pro Ala Glu Thr 
            100                 105                 110         


Thr Val Arg Leu Arg Ala Tyr Leu Asn Thr Pro Gly Leu Pro Val Cys 
        115                 120                 125             


Gln Asp His Leu Glu Phe Trp Glu Ser Val Phe Thr Gly Leu Thr His 
    130                 135                 140                 


Ile Asp Ala His Phe Leu Ser Gln Thr Lys Gln Gln Gly Leu Asn Phe 
145                 150                 155                 160 


Pro Tyr Leu Val Ala Tyr Gln Ala Thr Val Cys Ala Arg Ala Gln Ala 
                165                 170                 175     


Pro Pro Pro Ser Trp Asp Glu Met Trp Lys Cys Leu Val Arg Leu Lys 
            180                 185                 190         


Pro Thr Leu His Gly Pro Thr Pro Leu Leu Tyr Arg Leu Gly Ala Val 
        195                 200                 205             


Gln Asn 
    210 


<210>  57
<211>  210
<212>  PRT
<213>  Homo sapiens

<400>  57

Ser Val Ile Pro Thr Ala Gly Asp Val Val Val Cys Ala Thr Asp Ala 
1               5                   10                  15      


Leu Met Thr Gly Phe Thr Gly Asp Phe Asp Ser Val Ile Asp Cys Asn 
            20                  25                  30          


Val Ala Val Glu Gln Tyr Val Asp Phe Ser Leu Asp Pro Thr Phe Ser 
        35                  40                  45              


Ile Glu Thr Arg Thr Ala Pro Gln Asp Ala Val Ser Arg Ser Gln Arg 
    50                  55                  60                  


Arg Gly Arg Thr Gly Arg Gly Arg Leu Gly Thr Tyr Arg Tyr Val Gly 
65                  70                  75                  80  


Pro Gly Glu Arg Pro Ser Gly Met Phe Asp Ser Val Val Leu Cys Glu 
                85                  90                  95      


Cys Tyr Asp Ala Gly Cys Ala Trp Tyr Glu Leu Gln Pro Ala Glu Thr 
            100                 105                 110         


Thr Val Arg Leu Arg Ala Tyr Leu Ser Thr Pro Gly Leu Pro Val Cys 
        115                 120                 125             


Gln Asp His Leu Asp Phe Trp Glu Ser Val Phe Thr Gly Leu Thr His 
    130                 135                 140                 


Ile Asp Ala His Phe Leu Ser Gln Thr Lys Gln Gln Gly Leu Asn Phe 
145                 150                 155                 160 


Pro Tyr Leu Thr Ala Tyr Gln Ala Thr Val Cys Ala Arg Ala Gln Ala 
                165                 170                 175     


Pro Pro Pro Ser Trp Asp Glu Met Trp Lys Cys Leu Val Arg Leu Lys 
            180                 185                 190         


Pro Thr Leu His Gly Pro Thr Pro Leu Leu Tyr Arg Leu Gly Pro Val 
        195                 200                 205             


Gln Asn 
    210 


<210>  58
<211>  40
<212>  PRT
<213>  Homo sapiens

<400>  58

Met Ala Cys Met Ser Ala Asp Leu Glu Val Thr Thr Ser Thr Trp Val 
1               5                   10                  15      


Leu Leu Gly Gly Val Leu Ala Ala Leu Ala Ala Tyr Cys Leu Ser Thr 
            20                  25                  30          


Gly Cys Val Val Ile Val Gly His 
        35                  40  


<210>  59
<211>  40
<212>  PRT
<213>  Homo sapiens

<400>  59

Met Ala Cys Met Ser Ala Asp Leu Glu Val Thr Thr Ser Thr Trp Val 
1               5                   10                  15      


Leu Leu Gly Gly Val Leu Ala Ala Leu Ala Ala Tyr Cys Leu Ser Val 
            20                  25                  30          


Gly Cys Val Val Ile Val Gly His 
        35                  40  


<210>  60
<211>  36
<212>  PRT
<213>  Homo sapiens

<400>  60

Phe Trp Ala Lys His Met Trp Asn Phe Ile Ser Gly Ile Gln Tyr Leu 
1               5                   10                  15      


Ala Gly Leu Ser Thr Leu Pro Gly Asn Pro Ala Ile Ala Ser Leu Met 
            20                  25                  30          


Ala Phe Thr Ala 
        35      


<210>  61
<211>  114
<212>  PRT
<213>  Homo sapiens

<400>  61

Ile Gly Ser Ile Gly Leu Gly Lys Val Leu Val Asp Ile Leu Ala Gly 
1               5                   10                  15      


Tyr Gly Ala Gly Val Ala Gly Ala Leu Val Ala Phe Lys Ile Met Gly 
            20                  25                  30          


Gly Glu Leu Pro Ser Thr Glu Asp Met Val Asn Leu Leu Pro Ala Ile 
        35                  40                  45              


Leu Ser Pro Gly Ala Leu Val Val Gly Val Val Cys Ala Ala Ile Leu 
    50                  55                  60                  


Arg Arg His Val Gly Pro Gly Glu Gly Ala Val Gln Trp Met Asn Arg 
65                  70                  75                  80  


Leu Ile Ala Phe Ala Ser Arg Gly Asn His Val Ser Pro Thr His Tyr 
                85                  90                  95      


Val Pro Glu Ser Asp Ala Ala Ala Arg Val Thr Ala Ile Leu Ser Ser 
            100                 105                 110         


Leu Thr 
        


<210>  62
<211>  114
<212>  PRT
<213>  Homo sapiens

<400>  62

Ile Gly Ser Val Gly Leu Gly Lys Val Leu Val Asp Ile Leu Ala Gly 
1               5                   10                  15      


Tyr Gly Ala Gly Val Ala Gly Ala Leu Val Ala Phe Lys Ile Met Ser 
            20                  25                  30          


Gly Glu Ile Pro Ser Thr Glu Asp Leu Val Asn Leu Leu Pro Ala Ile 
        35                  40                  45              


Leu Ser Pro Gly Ala Leu Val Val Gly Val Val Cys Ala Ala Ile Leu 
    50                  55                  60                  


Arg Arg His Val Gly Pro Gly Glu Gly Ala Val Gln Trp Met Asn Arg 
65                  70                  75                  80  


Leu Ile Ala Phe Ala Ser Arg Gly Asn His Val Ser Pro Thr His Tyr 
                85                  90                  95      


Val Pro Glu Ser Asp Ala Ala Ala Arg Val Thr Ala Ile Leu Ser Ser 
            100                 105                 110         


Leu Thr 
        


<210>  63
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  63

Cys Pro Cys Gln Val Pro Ala Pro Glu Phe Phe Thr Glu Val Asp Gly 
1               5                   10                  15      


Val Arg Leu His Arg 
            20      


<210>  64
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  64

Ile Gly Ser Gln Leu Pro Cys Glu Pro Glu Pro Asp Val Ser Val Leu 
1               5                   10                  15      


Thr Ser Met Leu 
            20  


<210>  65
<211>  35
<212>  PRT
<213>  Homo sapiens

<400>  65

Thr Ala Ala Arg Arg Leu Ala Arg Gly Ser Pro Pro Ser Glu Ala Ser 
1               5                   10                  15      


Ser Ser Ala Ser Gln Leu Ser Ala Pro Ser Leu Lys Ala Thr Cys Gln 
            20                  25                  30          


Thr His His 
        35  


<210>  66
<211>  35
<212>  PRT
<213>  Homo sapiens

<400>  66

Thr Ala Ala Arg Arg Leu Ala Arg Gly Ser Pro Pro Ser Glu Ala Ser 
1               5                   10                  15      


Ser Ser Ala Ser Gln Leu Ser Ala Pro Ser Leu Lys Ala Thr Cys Gln 
            20                  25                  30          


Thr His Arg 
        35  


<210>  67
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  67

Glu Ser Asp Ser Glu Ser Cys Ser Ser Met Pro Pro Leu Glu Gly Glu 
1               5                   10                  15      


Pro Gly Asp Pro Asp Leu Ser Asp Gly Ser Trp Ser Thr Val Ser Asp 
            20                  25                  30          


<210>  68
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  68

Glu Ser Asp Ser Glu Ser Cys Ser Ser Met Pro Pro Leu Glu Gly Glu 
1               5                   10                  15      


Pro Gly Asp Pro Asp Leu Ser Cys Asp Ser Trp Ser Thr Val Ser Asp 
            20                  25                  30          


<210>  69
<211>  71
<212>  PRT
<213>  Homo sapiens

<400>  69

Gln Asp Val Val Cys Cys Ser Met Ser Tyr Ser Trp Thr Gly Ala Leu 
1               5                   10                  15      


Ile Thr Pro Cys Ala Ala Glu Glu Glu Lys Leu Pro Ile Asn Pro Leu 
            20                  25                  30          


Ser Asn Ser Leu Leu Arg His His Asn Leu Val Tyr Ser Thr Ser Ser 
        35                  40                  45              


Arg Ser Ala Ser Gln Arg Gln Lys Lys Val Thr Phe Asp Arg Leu Gln 
    50                  55                  60                  


Val Leu Asp Asp His Tyr Lys 
65                  70      


<210>  70
<211>  71
<212>  PRT
<213>  Homo sapiens

<400>  70

Gln Ser Val Val Cys Cys Ser Met Ser Tyr Ser Trp Thr Gly Ala Leu 
1               5                   10                  15      


Ile Thr Pro Cys Ser Ala Glu Glu Glu Lys Leu Pro Ile Asn Pro Leu 
            20                  25                  30          


Ser Asn Ser Leu Leu Arg His His Asn Leu Val Tyr Ser Thr Ser Ser 
        35                  40                  45              


Arg Ser Ala Ser Gln Arg Gln Lys Lys Val Thr Phe Asp Arg Leu Gln 
    50                  55                  60                  


Val Leu Asp Asp His Tyr Lys 
65                  70      


<210>  71
<211>  30
<212>  PRT
<213>  Homo sapiens

<400>  71

Pro Glu Lys Gly Gly Arg Lys Pro Ala Arg Leu Ile Val Tyr Pro Asp 
1               5                   10                  15      


Leu Gly Val Arg Val Cys Glu Lys Met Ala Leu Tyr Asp Val 
            20                  25                  30  


<210>  72
<211>  31
<212>  PRT
<213>  Homo sapiens

<400>  72

Trp Thr Ser Lys Lys Thr Pro Met Gly Phe Ser Tyr Asp Thr Arg Cys 
1               5                   10                  15      


Phe Asp Ser Thr Val Thr Glu Gln Asp Ile Arg Val Glu Glu Glu 
            20                  25                  30      


<210>  73
<211>  30
<212>  PRT
<213>  Homo sapiens

<400>  73

Cys Gly Tyr Arg Arg Cys Arg Ala Ser Gly Val Leu Pro Thr Ser Cys 
1               5                   10                  15      


Gly Asn Thr Leu Thr Cys Tyr Ile Lys Ala Thr Ala Ala Cys 
            20                  25                  30  


<210>  74
<211>  30
<212>  PRT
<213>  Homo sapiens

<400>  74

Cys Gly Tyr Arg Arg Cys Arg Ala Ser Gly Val Leu Thr Thr Ser Cys 
1               5                   10                  15      


Gly Asn Thr Leu Thr Cys Tyr Ile Lys Ala Arg Ala Ala Cys 
            20                  25                  30  


<210>  75
<211>  22
<212>  PRT
<213>  Homo sapiens

<400>  75

Ala Leu Arg Ala Phe Thr Glu Ala Met Thr Arg Tyr Ser Ala Pro Pro 
1               5                   10                  15      


Gly Asp Ala Pro Gln Pro 
            20          


<210>  76
<211>  49
<212>  PRT
<213>  Homo sapiens

<400>  76

Lys Gly Lys Arg Val Tyr Tyr Leu Thr Arg Asp Pro Thr Thr Pro Leu 
1               5                   10                  15      


Ala Arg Ala Ala Trp Glu Thr Ala Arg His Thr Pro Val Asn Ser Trp 
            20                  25                  30          


Leu Gly Asn Ile Ile Met Tyr Ala Pro Thr Ile Trp Val Arg Met Val 
        35                  40                  45              


Leu 
    


<210>  77
<211>  49
<212>  PRT
<213>  Homo sapiens

<400>  77

Lys Gly Lys Arg Tyr Tyr Tyr Leu Thr Arg Asp Pro Thr Thr Pro Leu 
1               5                   10                  15      


Ala Arg Ala Ala Trp Glu Thr Ala Arg His Thr Pro Val Asn Ser Trp 
            20                  25                  30          


Leu Gly Asn Ile Ile Met Tyr Ala Pro Thr Ile Trp Val Arg Met Val 
        35                  40                  45              


Met 
    


<210>  78
<211>  56
<212>  PRT
<213>  Homo sapiens

<400>  78

Tyr Gly Ala Thr Tyr Ser Val Glu Pro Leu Asp Leu Pro Ala Ile Ile 
1               5                   10                  15      


Glu Arg Leu His Gly Leu Ser Ala Phe Ser Leu His Ser Tyr Ser Pro 
            20                  25                  30          


Gly Glu Ile Asn Arg Val Ala Gly Cys Leu Arg Lys Leu Gly Cys Pro 
        35                  40                  45              


Pro Leu Arg Ala Trp Arg His Arg 
    50                  55      


<210>  79
<211>  56
<212>  PRT
<213>  Homo sapiens

<400>  79

Tyr Gly Ala Thr Tyr Ser Val Thr Pro Leu Asp Leu Pro Ala Ile Ile 
1               5                   10                  15      


Glu Arg Leu His Gly Leu Ser Ala Phe Thr Leu His Ser Tyr Ser Pro 
            20                  25                  30          


Val Glu Leu Asn Arg Val Ala Gly Thr Leu Arg Lys Leu Gly Cys Pro 
        35                  40                  45              


Pro Leu Arg Ala Trp Arg His Arg 
    50                  55      


<210>  80
<211>  27
<212>  PRT
<213>  Homo sapiens

<400>  80

Val Arg Ala Lys Leu Leu Ser Gln Gly Gly Arg Ala Ala Ile Cys Gly 
1               5                   10                  15      


Lys Tyr Leu Phe Asn Trp Ala Val Arg Thr Lys 
            20                  25          


<210>  81
<211>  180
<212>  PRT
<213>  Homo sapiens

<400>  81

Thr Lys Arg Asn Thr Asn Arg Arg Pro Gln Asp Val Lys Phe Pro Gly 
1               5                   10                  15      


Gly Gly Gln Ile Val Gly Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro 
            20                  25                  30          


Arg Leu Gly Val Arg Ala Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro 
        35                  40                  45              


Arg Gly Arg Arg Gln Pro Ile Pro Lys Ala Arg Arg Pro Glu Gly Arg 
    50                  55                  60                  


Ser Trp Ala Gln Pro Gly Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly 
65                  70                  75                  80  


Cys Gly Trp Ala Gly Trp Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser 
                85                  90                  95      


Trp Gly Pro Asn Asp Pro Arg Arg Arg Ser Arg Asn Leu Gly Lys Val 
            100                 105                 110         


Ile Asp Thr Leu Thr Cys Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro 
        115                 120                 125             


Leu Val Gly Ala Pro Val Gly Gly Val Ala Arg Ala Leu Ala His Gly 
    130                 135                 140                 


Val Arg Val Leu Glu Asp Gly Ile Asn Tyr Ala Thr Gly Asn Leu Pro 
145                 150                 155                 160 


Gly Cys Ser Phe Ser Ile Phe Leu Leu Ala Leu Leu Ser Cys Leu Thr 
                165                 170                 175     


Val Pro Ala Ser 
            180 


<210>  82
<211>  180
<212>  PRT
<213>  Homo sapiens

<400>  82

Thr Lys Arg Asn Thr Asn Arg Arg Pro Met Asp Val Lys Phe Pro Gly 
1               5                   10                  15      


Gly Gly Gln Ile Val Gly Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro 
            20                  25                  30          


Arg Leu Gly Val Arg Ala Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro 
        35                  40                  45              


Arg Gly Arg Arg Gln Pro Ile Pro Lys Ala Arg Arg Pro Glu Gly Arg 
    50                  55                  60                  


Ser Trp Ala Gln Pro Gly Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly 
65                  70                  75                  80  


Cys Gly Trp Ala Gly Trp Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser 
                85                  90                  95      


Trp Gly Pro Asn Asp Pro Arg Arg Arg Ser Arg Asn Leu Gly Lys Val 
            100                 105                 110         


Ile Asp Thr Leu Thr Cys Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro 
        115                 120                 125             


Leu Val Gly Ala Pro Val Gly Gly Val Ala Arg Ala Leu Ala His Gly 
    130                 135                 140                 


Val Arg Ala Leu Glu Asp Gly Ile Asn Tyr Ala Thr Gly Asn Leu Pro 
145                 150                 155                 160 


Gly Cys Ser Phe Ser Ile Phe Leu Leu Ala Leu Leu Ser Cys Leu Thr 
                165                 170                 175     


Val Pro Ala Ser 
            180 


<210>  83
<211>  27
<212>  PRT
<213>  Homo sapiens

<400>  83

Cys Asn Cys Ser Ile Tyr Pro Gly His Ile Thr Gly His Arg Met Ala 
1               5                   10                  15      


Trp Asp Met Met Met Asn Trp Ser Pro Thr Thr 
            20                  25          


<210>  84
<211>  22
<212>  PRT
<213>  Homo sapiens

<400>  84

Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Ser 
1               5                   10                  15      


Leu Asn Thr Gly Phe Ile 
            20          


<210>  85
<211>  44
<212>  PRT
<213>  Homo sapiens

<400>  85

Cys Pro Thr Asp Cys Phe Arg Lys His Pro Glu Ala Thr Tyr Thr Lys 
1               5                   10                  15      


Cys Gly Ser Gly Pro Trp Leu Thr Pro Arg Cys Leu Val Asp Tyr Pro 
            20                  25                  30          


Tyr Arg Leu Trp His Tyr Pro Cys Thr Val Asn Phe 
        35                  40                  


<210>  86
<211>  43
<212>  PRT
<213>  Homo sapiens

<400>  86

Leu Leu His Ser Thr Thr Glu Trp Ala Ile Leu Pro Cys Ser Phe Thr 
1               5                   10                  15      


Thr Leu Pro Ala Leu Ser Thr Gly Leu Ile His Leu His Gln Asn Ile 
            20                  25                  30          


Val Asp Val Gln Tyr Leu Tyr Gly Val Gly Ser 
        35                  40              


<210>  87
<211>  43
<212>  PRT
<213>  Homo sapiens

<400>  87

Leu Leu Leu Ser Thr Thr Glu Trp Gln Ile Leu Pro Cys Ser Phe Thr 
1               5                   10                  15      


Thr Leu Pro Ala Leu Ser Thr Gly Leu Ile His Leu His Gln Asn Ile 
            20                  25                  30          


Val Asp Val Gln Tyr Leu Tyr Gly Val Gly Ser 
        35                  40              


<210>  88
<211>  33
<212>  PRT
<213>  Homo sapiens

<400>  88

Lys Gly Trp Arg Leu Leu Ala Pro Ile Thr Ala Tyr Ala Gln Gln Thr 
1               5                   10                  15      


Arg Gly Leu Leu Gly Thr Ile Val Thr Ser Leu Thr Gly Arg Asp Lys 
            20                  25                  30          


Asn 
    


<210>  89
<211>  33
<212>  PRT
<213>  Homo sapiens

<400>  89

Met Gly Trp Arg Leu Leu Ala Pro Ile Thr Ala Tyr Ala Gln Gln Thr 
1               5                   10                  15      


Arg Gly Leu Leu Gly Thr Ile Val Thr Ser Leu Thr Gly Arg Asp Lys 
            20                  25                  30          


Asn 
    


<210>  90
<211>  81
<212>  PRT
<213>  Homo sapiens

<400>  90

Pro Cys Thr Cys Gly Ser Ser Asp Leu Tyr Leu Val Thr Arg His Ala 
1               5                   10                  15      


Asp Val Ile Pro Ala Arg Arg Arg Gly Asp Ser Arg Ala Ser Leu Leu 
            20                  25                  30          


Ser Pro Arg Pro Ile Ser Thr Leu Lys Gly Ser Ser Gly Gly Pro Val 
        35                  40                  45              


Leu Cys Pro Ser Gly His Val Val Gly Ile Phe Arg Ala Ala Val Cys 
    50                  55                  60                  


Thr Arg Gly Val Ala Lys Ala Leu Asp Phe Ile Pro Val Glu Ser Leu 
65                  70                  75                  80  


Glu 
    


<210>  91
<211>  81
<212>  PRT
<213>  Homo sapiens

<400>  91

Pro Cys Thr Cys Gly Ser Ser Asp Leu Tyr Leu Val Thr Arg His Ala 
1               5                   10                  15      


Asp Val Ile Pro Val Arg Arg Arg Gly Asp Ser Arg Gly Ser Leu Leu 
            20                  25                  30          


Ser Pro Arg Pro Ile Ser Tyr Leu Lys Gly Ser Ser Gly Gly Pro Val 
        35                  40                  45              


Leu Cys Pro Ser Gly His Ala Val Gly Ile Phe Arg Ala Ala Val Cys 
    50                  55                  60                  


Thr Arg Gly Val Ala Lys Ala Val Asp Phe Ile Pro Val Glu Ser Leu 
65                  70                  75                  80  


Glu 
    


<210>  92
<211>  70
<212>  PRT
<213>  Homo sapiens

<400>  92

Met Arg Ser Pro Val Phe Thr Asp Asn Ser Thr Pro Pro Ala Val Pro 
1               5                   10                  15      


Gln Thr Tyr Gln Val Gly His Leu His Ala Pro Thr Gly Ser Gly Lys 
            20                  25                  30          


Ser Thr Lys Val Pro Ala Ala Tyr Ala Ala Gln Gly Tyr Lys Val Leu 
        35                  40                  45              


Val Leu Asn Pro Ser Val Ala Ala Thr Leu Gly Phe Gly Ala Tyr Met 
    50                  55                  60                  


Ser Lys Ala Tyr Gly Ile 
65                  70  


<210>  93
<211>  70
<212>  PRT
<213>  Homo sapiens

<400>  93

Met Arg Ser Pro Val Phe Thr Asp Asn Ser Thr Pro Pro Ala Val Pro 
1               5                   10                  15      


Gln Thr Tyr Gln Val Ala His Leu His Ala Pro Thr Gly Ser Gly Lys 
            20                  25                  30          


Ser Thr Lys Val Pro Ala Ala Tyr Ala Ala Gln Gly Tyr Lys Val Leu 
        35                  40                  45              


Val Leu Asn Pro Ser Val Ala Ala Thr Leu Gly Phe Gly Ala Tyr Met 
    50                  55                  60                  


Ser Lys Ala Tyr Gly Ile 
65                  70  


<210>  94
<211>  75
<212>  PRT
<213>  Homo sapiens

<400>  94

Arg Thr Gly Val Arg Thr Val Thr Thr Gly Ala Pro Ile Thr Tyr Ser 
1               5                   10                  15      


Thr Tyr Gly Lys Phe Leu Ala Asp Gly Gly Cys Ser Gly Gly Ala Tyr 
            20                  25                  30          


Asp Ile Ile Ile Cys Asp Glu Cys His Ser Thr Asp Ala Thr Thr Ile 
        35                  40                  45              


Leu Gly Ile Gly Thr Val Leu Asp Gln Ala Glu Thr Ala Gly Val Arg 
    50                  55                  60                  


Leu Val Val Leu Ala Thr Ala Thr Pro Pro Gly 
65                  70                  75  


<210>  95
<211>  75
<212>  PRT
<213>  Homo sapiens

<400>  95

Arg Ser Gly Val Arg Thr Ile Thr Thr Gly Ala Pro Ile Thr Tyr Ser 
1               5                   10                  15      


Thr Tyr Gly Lys Phe Leu Ala Asp Gly Gly Cys Ser Gly Gly Ala Tyr 
            20                  25                  30          


Asp Ile Ile Ile Cys Asp Glu Cys His Ser Thr Asp Ser Thr Thr Ile 
        35                  40                  45              


Leu Gly Ile Gly Thr Val Leu Asp Gln Ala Glu Thr Ala Gly Val Arg 
    50                  55                  60                  


Leu Val Val Leu Ala Thr Ala Thr Pro Pro Gly 
65                  70                  75  


<210>  96
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  96

Ile Lys Gly Gly Arg His Leu Ile Phe Cys His Ser Lys Lys Lys Cys 
1               5                   10                  15      


Asp Glu Leu Ala 
            20  


<210>  97
<211>  196
<212>  PRT
<213>  Homo sapiens

<400>  97

Asn Ala Val Ala Tyr Tyr Arg Gly Leu Asp Val Ser Val Ile Pro Thr 
1               5                   10                  15      


Ser Gly Asp Val Val Val Cys Ala Thr Asp Ala Leu Met Thr Gly Phe 
            20                  25                  30          


Thr Gly Asp Phe Asp Ser Val Ile Asp Cys Asn Val Ala Val Thr Gln 
        35                  40                  45              


Thr Val Asp Phe Ser Leu Asp Pro Thr Phe Thr Ile Glu Thr Thr Thr 
    50                  55                  60                  


Val Pro Gln Asp Ala Val Ser Arg Ser Gln Arg Arg Gly Arg Thr Gly 
65                  70                  75                  80  


Arg Gly Arg Leu Gly Ile Tyr Arg Tyr Val Ser Pro Gly Glu Arg Pro 
                85                  90                  95      


Ser Gly Met Phe Asp Ser Val Val Leu Cys Glu Cys Tyr Asp Ala Gly 
            100                 105                 110         


Cys Ala Trp Tyr Glu Leu Thr Pro Ala Glu Thr Thr Val Arg Leu Arg 
        115                 120                 125             


Ala Tyr Leu Asn Thr Pro Gly Leu Pro Val Cys Gln Asp His Leu Glu 
    130                 135                 140                 


Phe Trp Glu Gly Val Phe Thr Gly Leu Thr His Ile Asp Ala His Phe 
145                 150                 155                 160 


Leu Ser Gln Thr Lys Gln Gly Gly Glu Asn Phe Pro Tyr Leu Val Ala 
                165                 170                 175     


Tyr Gln Ala Thr Val Cys Ala Arg Ala Lys Ala Pro Pro Pro Ser Trp 
            180                 185                 190         


Asp Thr Met Trp 
        195     


<210>  98
<211>  196
<212>  PRT
<213>  Homo sapiens

<400>  98

Asn Ala Val Ala Tyr Tyr Arg Gly Leu Asp Val Ser Val Ile Pro Thr 
1               5                   10                  15      


Ser Gly Asp Val Val Val Val Ala Thr Asp Ala Leu Met Thr Gly Phe 
            20                  25                  30          


Thr Gly Asp Phe Asp Ser Val Ile Asp Cys Asn Thr Cys Val Thr Gln 
        35                  40                  45              


Thr Val Asp Phe Ser Leu Asp Pro Thr Phe Thr Ile Glu Thr Thr Thr 
    50                  55                  60                  


Val Pro Gln Asp Ala Val Ser Arg Ser Gln Arg Arg Gly Arg Thr Gly 
65                  70                  75                  80  


Arg Gly Arg Arg Gly Ile Tyr Arg Phe Val Thr Pro Gly Glu Arg Pro 
                85                  90                  95      


Ser Gly Met Phe Asp Ser Ser Val Leu Cys Glu Cys Tyr Asp Ala Gly 
            100                 105                 110         


Cys Ala Trp Tyr Glu Leu Thr Pro Ala Glu Thr Ser Val Arg Leu Arg 
        115                 120                 125             


Ala Tyr Leu Asn Thr Pro Gly Leu Pro Val Cys Gln Asp His Leu Glu 
    130                 135                 140                 


Phe Trp Glu Gly Val Phe Thr Gly Leu Thr His Ile Asp Ala His Phe 
145                 150                 155                 160 


Leu Ser Gln Thr Lys Gln Ala Gly Asp Asn Phe Pro Tyr Leu Val Ala 
                165                 170                 175     


Tyr Gln Ala Thr Val Cys Ala Arg Ala Gln Ala Pro Pro Pro Ser Trp 
            180                 185                 190         


Asp Gln Met Trp 
        195     


<210>  99
<211>  47
<212>  PRT
<213>  Homo sapiens

<400>  99

Thr His Pro Ile Thr Lys Tyr Ile Met Ala Cys Met Ser Ala Asp Leu 
1               5                   10                  15      


Glu Val Val Thr Ser Thr Trp Val Leu Val Gly Gly Val Leu Ala Ala 
            20                  25                  30          


Leu Ala Ala Tyr Cys Leu Ser Val Gly Cys Val Val Ile Val Gly 
        35                  40                  45          


<210>  100
<211>  47
<212>  PRT
<213>  Homo sapiens

<400>  100

Thr His Pro Ile Thr Lys Tyr Ile Met Ala Cys Met Ser Ala Asp Leu 
1               5                   10                  15      


Glu Val Val Thr Ser Thr Trp Val Leu Val Gly Gly Val Leu Ala Ala 
            20                  25                  30          


Leu Ala Ala Tyr Cys Leu Ser Val Gly Ser Val Val Ile Val Gly 
        35                  40                  45          


<210>  101
<211>  42
<212>  PRT
<213>  Homo sapiens

<400>  101

Phe Trp Ala Lys His Met Trp Asn Phe Ile Ser Gly Ile Gln Tyr Leu 
1               5                   10                  15      


Ala Gly Leu Ser Thr Leu Pro Gly Asn Pro Ala Val Ala Ser Leu Met 
            20                  25                  30          


Ala Phe Thr Ala Ala Val Thr Ser Pro Leu 
        35                  40          


<210>  102
<211>  42
<212>  PRT
<213>  Homo sapiens

<400>  102

Phe Trp Ala Lys His Met Trp Asn Phe Ile Ser Gly Ile Gln Tyr Leu 
1               5                   10                  15      


Ala Gly Leu Ser Thr Leu Pro Gly Asn Pro Ala Ile Ala Ser Leu Met 
            20                  25                  30          


Ala Phe Thr Ala Ala Val Thr Ser Pro Leu 
        35                  40          


<210>  103
<211>  109
<212>  PRT
<213>  Homo sapiens

<400>  103

Gly Ala Ala Val Gly Ser Ile Gly Leu Gly Lys Val Leu Val Asp Ile 
1               5                   10                  15      


Leu Ala Gly Tyr Gly Ala Gly Val Ala Gly Ala Leu Val Ala Phe Lys 
            20                  25                  30          


Ile Met Ser Gly Glu Lys Pro Ser Thr Glu Asp Leu Val Asn Leu Leu 
        35                  40                  45              


Pro Ala Ile Leu Ser Pro Gly Ala Leu Val Val Gly Val Val Cys Ala 
    50                  55                  60                  


Ala Ile Leu Arg Arg His Val Gly Pro Gly Glu Gly Ala Val Gln Trp 
65                  70                  75                  80  


Met Asn Arg Leu Ile Ala Phe Ala Ser Arg Gly Asn His Val Ser Pro 
                85                  90                  95      


Thr His Tyr Val Pro Glu Ser Asp Ala Ala Ala Arg Val 
            100                 105                 


<210>  104
<211>  109
<212>  PRT
<213>  Homo sapiens

<400>  104

Gly Ala Ala Val Gly Ser Val Gly Leu Gly Lys Val Leu Val Asp Ile 
1               5                   10                  15      


Leu Ala Gly Tyr Gly Ala Gly Val Ala Gly Ala Leu Val Ala Phe Lys 
            20                  25                  30          


Ile Met Ser Gly Glu Val Pro Ser Thr Glu Asp Leu Val Asn Leu Leu 
        35                  40                  45              


Pro Ala Ile Leu Ser Pro Gly Ala Leu Val Val Gly Val Val Cys Ala 
    50                  55                  60                  


Ala Ile Leu Arg Arg His Val Gly Pro Gly Glu Gly Ala Val Gln Trp 
65                  70                  75                  80  


Met Asn Arg Leu Ile Ala Phe Ala Ser Arg Gly Asn His Val Ser Pro 
                85                  90                  95      


Thr His Tyr Val Pro Glu Ser Asp Ala Ala Ala Arg Val 
            100                 105                 


<210>  105
<211>  35
<212>  PRT
<213>  Homo sapiens

<400>  105

Thr Ala Glu Thr Ala Ala Arg Arg Leu Ala Arg Gly Ser Pro Pro Ser 
1               5                   10                  15      


Leu Ala Ser Ser Ser Ala Ser Gln Leu Ser Ala Pro Ser Leu Lys Ala 
            20                  25                  30          


Thr Cys Thr 
        35  


<210>  106
<211>  59
<212>  PRT
<213>  Homo sapiens

<400>  106

Val Cys Cys Ser Met Ser Tyr Ser Trp Thr Gly Ala Leu Ile Thr Pro 
1               5                   10                  15      


Cys Ala Ala Glu Glu Glu Lys Leu Pro Ile Asn Pro Leu Ser Asn Ser 
            20                  25                  30          


Leu Leu Arg His His Asn Leu Val Tyr Ser Thr Thr Ser Arg Ser Ala 
        35                  40                  45              


Ser Leu Arg Gln Lys Lys Val Thr Phe Asp Arg 
    50                  55                  


<210>  107
<211>  59
<212>  PRT
<213>  Homo sapiens

<400>  107

Val Cys Cys Ser Met Ser Tyr Ser Trp Thr Gly Ala Leu Ile Thr Pro 
1               5                   10                  15      


Cys Ala Ala Glu Glu Glu Lys Leu Pro Ile Asn Pro Leu Ser Asn Ser 
            20                  25                  30          


Leu Ile Arg His His Asn Met Val Tyr Ser Thr Thr Ser Arg Ser Ala 
        35                  40                  45              


Ser Leu Arg Gln Lys Lys Val Thr Phe Asp Arg 
    50                  55                  


<210>  108
<211>  30
<212>  PRT
<213>  Homo sapiens

<400>  108

Pro Ser Lys Gly Gly Arg Lys Pro Ala Arg Leu Ile Val Tyr Pro Asp 
1               5                   10                  15      


Leu Gly Val Arg Val Cys Glu Lys Arg Ala Leu Tyr Asp Val 
            20                  25                  30  


<210>  109
<211>  26
<212>  PRT
<213>  Homo sapiens

<400>  109

Lys Lys Thr Pro Met Gly Phe Ser Tyr Asp Thr Arg Cys Phe Asp Ser 
1               5                   10                  15      


Thr Val Thr Glu Arg Asp Ile Arg Thr Glu 
            20                  25      


<210>  110
<211>  29
<212>  PRT
<213>  Homo sapiens

<400>  110

Cys Gly Tyr Arg Arg Cys Arg Ala Ser Gly Val Leu Thr Thr Ser Met 
1               5                   10                  15      


Gly Asn Thr Leu Thr Cys Tyr Ile Lys Ala Leu Ala Ala 
            20                  25                  


<210>  111
<211>  29
<212>  PRT
<213>  Homo sapiens

<400>  111

Cys Gly Tyr Arg Arg Cys Arg Ala Ser Gly Val Leu Thr Thr Ser Met 
1               5                   10                  15      


Gly Asn Thr Ile Thr Cys Tyr Ile Lys Ala Leu Ala Ala 
            20                  25                  


<210>  112
<211>  35
<212>  PRT
<213>  Homo sapiens

<400>  112

Glu Ala Met Thr Arg Tyr Ser Ala Pro Pro Gly Asp Pro Pro Gln Pro 
1               5                   10                  15      


Glu Tyr Asp Leu Glu Leu Ile Thr Ser Cys Ser Ser Asn Val Ser Val 
            20                  25                  30          


Ala His Asp 
        35  


<210>  113
<211>  45
<212>  PRT
<213>  Homo sapiens

<400>  113

Thr Pro Leu Ala Arg Ala Ala Trp Glu Thr Ala Arg His Thr Pro Val 
1               5                   10                  15      


Asn Ser Trp Leu Gly Asn Ile Ile Met Tyr Ala Pro Thr Ile Trp Val 
            20                  25                  30          


Arg Met Val Leu Met Thr His Phe Phe Ser Ile Leu Gln 
        35                  40                  45  


<210>  114
<211>  31
<212>  PRT
<213>  Homo sapiens

<400>  114

Tyr Gly Ala Thr Tyr Ser Val Thr Pro Leu Asp Leu Pro Ala Ile Ile 
1               5                   10                  15      


Gln Arg Leu His Gly Leu Ser Ala Phe Ser Leu His Ser Tyr Ser 
            20                  25                  30      


<210>  115
<211>  31
<212>  PRT
<213>  Homo sapiens

<400>  115

Tyr Gly Ala Thr Tyr Ser Val Thr Pro Leu Asp Leu Pro Ala Ile Ile 
1               5                   10                  15      


Glu Arg Leu His Gly Leu Ser Ala Phe Thr Leu His Ser Tyr Ser 
            20                  25                  30      


<210>  116
<211>  50
<212>  PRT
<213>  Homo sapiens

<400>  116

Glu Leu Asn Arg Val Ala Ala Cys Leu Arg Lys Leu Gly Val Pro Pro 
1               5                   10                  15      


Leu Arg Ala Trp Arg His Arg Ala Arg Ala Val Arg Ala Lys Leu Ile 
            20                  25                  30          


Ala Gln Gly Gly Arg Ala Ala Ile Cys Gly Lys Tyr Leu Phe Asn Trp 
        35                  40                  45              


Ala Val 
    50  


<210>  117
<211>  50
<212>  PRT
<213>  Homo sapiens

<400>  117

Glu Leu Asn Arg Val Gly Ala Cys Leu Arg Lys Leu Gly Val Pro Pro 
1               5                   10                  15      


Leu Arg Ala Trp Arg His Arg Ala Arg Ala Val Arg Ala Lys Leu Ile 
            20                  25                  30          


Ala Gln Gly Gly Lys Ala Ala Ile Cys Gly Lys Tyr Leu Phe Asn Trp 
        35                  40                  45              


Ala Val 
    50  


<210>  118
<211>  1123
<212>  PRT
<213>  Homo sapiens

<400>  118

Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly 
1               5                   10                  15      


Ala Val Phe Val Ser Pro Ser Gln Glu Ile His Ala Arg Phe Arg Arg 
            20                  25                  30          


Lys Gly Gly Gly Pro Gly Gly Gly Lys Ser Thr Asn Pro Lys Pro Gln 
        35                  40                  45              


Arg Lys Thr Lys Arg Asn Thr Asn Arg Arg Pro Gln Asp Val Lys Phe 
    50                  55                  60                  


Pro Gly Gly Gly Gln Ile Val Gly Gly Val Tyr Leu Leu Pro Arg Arg 
65                  70                  75                  80  


Gly Pro Arg Leu Gly Val Arg Ala Thr Arg Lys Thr Ser Glu Arg Ser 
                85                  90                  95      


Gln Pro Arg Gly Arg Arg Gln Pro Ile Pro Lys Ala Arg Arg Pro Glu 
            100                 105                 110         


Gly Arg Thr Trp Ala Gln Pro Gly Tyr Pro Trp Pro Leu Tyr Gly Asn 
        115                 120                 125             


Glu Gly Cys Gly Trp Ala Gly Trp Leu Leu Ser Pro Arg Gly Ser Arg 
    130                 135                 140                 


Pro Ser Trp Gly Pro Thr Asp Pro Arg Arg Arg Ser Arg Asn Leu Gly 
145                 150                 155                 160 


Lys Val Ile Asp Thr Leu Thr Cys Gly Phe Ala Asp Leu Met Gly Tyr 
                165                 170                 175     


Ile Pro Leu Val Gly Ala Pro Leu Gly Gly Ala Ala Arg Ala Leu Ala 
            180                 185                 190         


His Gly Val Arg Val Leu Glu Asp Gly Val Asn Tyr Ala Thr Gly Asn 
        195                 200                 205             


Leu Pro Gly Cys Ser Phe Ser Ile Phe Leu Leu Ala Leu Leu Ser Cys 
    210                 215                 220                 


Leu Thr Val Pro Ala Ser Ala Gly Gly Ser Gly Asp Arg Asp Arg Ser 
225                 230                 235                 240 


Glu Leu Ser Pro Leu Leu Leu Ser Thr Thr Gln Trp Gln Val Leu Pro 
                245                 250                 255     


Cys Ser Phe Thr Thr Leu Pro Ala Leu Ser Thr Gly Leu Ile His Leu 
            260                 265                 270         


His Gln Asn Ile Val Asp Val Gln Tyr Leu Tyr Gly Val Gly Ser Ser 
        275                 280                 285             


Val Gly Pro Pro Cys Thr Cys Gly Ser Ser Asp Leu Tyr Leu Val Thr 
    290                 295                 300                 


Arg His Ala Asp Val Ile Pro Val Arg Arg Arg Gly Asp Ser Arg Gly 
305                 310                 315                 320 


Ser Leu Leu Ser Pro Arg Pro Ile Ser Tyr Leu Lys Gly Ser Ser Gly 
                325                 330                 335     


Gly Pro Leu Leu Cys Pro Ser Gly His Ala Val Gly Ile Phe Arg Ala 
            340                 345                 350         


Ala Val Cys Thr Arg Gly Val Ala Lys Ala Val Asp Phe Ile Pro Val 
        355                 360                 365             


Glu Ser Met Glu Thr Thr Met Arg Ser Pro Val Phe Thr Asp Asn Ser 
    370                 375                 380                 


Ser Pro Pro Ala Val Pro Gln Thr Phe Gln Val Ala His Leu His Ala 
385                 390                 395                 400 


Pro Thr Gly Ser Gly Lys Ser Thr Lys Val Pro Ala Ala Tyr Ala Ala 
                405                 410                 415     


Gln Gly Tyr Lys Val Leu Val Leu Asn Pro Ser Val Ala Ala Thr Leu 
            420                 425                 430         


Gly Phe Gly Ala Tyr Met Ser Lys Ala His Gly Val Ser Gly Thr Gly 
        435                 440                 445             


Val Arg Thr Ile Thr Thr Gly Ser Pro Ile Thr Tyr Ser Thr Tyr Gly 
    450                 455                 460                 


Lys Phe Leu Ala Asp Gly Gly Cys Ser Gly Gly Ala Tyr Asp Ile Ile 
465                 470                 475                 480 


Ile Cys Asp Glu Cys His Ser Thr Asp Ala Thr Ser Ile Leu Gly Ile 
                485                 490                 495     


Gly Thr Val Leu Asp Gln Ala Glu Thr Ala Gly Ala Arg Leu Val Val 
            500                 505                 510         


Leu Ala Thr Ala Thr Pro Pro Gly Ser Val Thr Val Pro His Pro Asn 
        515                 520                 525             


Ile Glu Glu Val Gly Pro Gly Asn Ala Val Ala Tyr Tyr Arg Gly Leu 
    530                 535                 540                 


Asp Val Ser Val Ile Pro Thr Ser Gly Asp Val Val Val Val Ala Thr 
545                 550                 555                 560 


Asp Ala Leu Met Thr Gly Phe Thr Gly Asp Phe Asp Ser Val Ile Asp 
                565                 570                 575     


Cys Asn Thr Cys Val Thr Gln Thr Val Asp Phe Ser Leu Asp Pro Thr 
            580                 585                 590         


Phe Thr Ile Glu Thr Thr Thr Leu Pro Gln Asp Ala Val Ser Arg Thr 
        595                 600                 605             


Gln Arg Arg Gly Arg Thr Gly Arg Gly Arg Pro Gly Gly Gly Ser Gly 
    610                 615                 620                 


Gly Gly Tyr Arg Phe Val Thr Pro Gly Glu Arg Pro Ser Gly Met Phe 
625                 630                 635                 640 


Asp Ser Ser Val Leu Cys Glu Cys Tyr Asp Ala Gly Cys Ala Trp Tyr 
                645                 650                 655     


Glu Leu Thr Pro Ala Glu Thr Thr Val Arg Leu Arg Ala Tyr Leu Asn 
            660                 665                 670         


Thr Pro Gly Leu Pro Val Cys Gln Asp His Leu Glu Phe Trp Glu Gly 
        675                 680                 685             


Val Phe Thr Gly Leu Thr His Ile Asp Ala His Phe Leu Ser Gln Thr 
    690                 695                 700                 


Lys Gln Ala Gly Asp Asn Phe Pro Tyr Leu Val Ala Tyr Gln Ala Thr 
705                 710                 715                 720 


Val Cys Ala Arg Ala Gln Ala Pro Pro Pro Ser Trp Asp Gln Met Trp 
                725                 730                 735     


Lys Cys Leu Ile Arg Leu Lys Pro Gly Gly Lys Gly Pro Gly Gly Lys 
            740                 745                 750         


Tyr Ile Met Thr Cys Met Ser Ala Asp Leu Glu Val Val Thr Ser Thr 
        755                 760                 765             


Trp Val Leu Val Gly Gly Val Leu Ala Ala Leu Ala Ala Tyr Cys Leu 
    770                 775                 780                 


Ser Thr Gly Cys Val Val Ile Val Gly Arg Ile Val Leu Ser Gly Gly 
785                 790                 795                 800 


Ser Gly Gly Ser Ile Gly Leu Gly Lys Val Leu Val Asp Ile Leu Ala 
                805                 810                 815     


Gly Tyr Gly Ala Gly Val Ala Gly Ala Leu Val Ala Phe Lys Ile Met 
            820                 825                 830         


Ser Gly Glu Val Pro Ser Thr Glu Asp Leu Val Asn Leu Leu Pro Ala 
        835                 840                 845             


Ile Leu Ser Pro Gly Ala Leu Val Val Gly Val Val Cys Ala Ala Ile 
    850                 855                 860                 


Leu Arg Arg His Val Gly Pro Gly Glu Gly Ala Val Gln Trp Met Asn 
865                 870                 875                 880 


Arg Leu Ile Ala Phe Ala Ser Arg Gly Asn His Val Ser Pro Thr His 
                885                 890                 895     


Tyr Val Pro Glu Ser Asp Ala Ala Ala Arg Val Thr Gln Ile Leu Ser 
            900                 905                 910         


Gly Pro Ser Leu Thr Glu Arg Leu Tyr Val Gly Gly Pro Leu Thr Asn 
        915                 920                 925             


Ser Lys Gly Gln Asn Cys Gly Tyr Arg Arg Cys Arg Ala Ser Gly Val 
    930                 935                 940                 


Leu Thr Thr Ser Cys Gly Asn Thr Leu Thr Cys Tyr Leu Lys Ala Ser 
945                 950                 955                 960 


Ala Ala Cys Arg Ala Ala Lys Leu Gly Gly Pro Gly Ser Leu Arg Ala 
                965                 970                 975     


Phe Thr Glu Ala Met Thr Arg Tyr Ser Ala Pro Pro Gly Asp Pro Pro 
            980                 985                 990         


Gln Pro Glu Tyr Asp Leu Glu Leu  Ile Thr Ser Cys Ser  Ser Asn Val 
        995                 1000                 1005             


Ser Val  Ala His Asp Ala Ser  Gly Lys Arg Val Tyr  Tyr Leu Thr 
    1010                 1015                 1020             


Arg Asp  Pro Thr Thr Pro Leu  Ala Arg Ala Ala Trp  Glu Thr Ala 
    1025                 1030                 1035             


Arg His  Thr Pro Val Asn Ser  Trp Leu Gly Asn Ile  Ile Met Tyr 
    1040                 1045                 1050             


Ala Pro  Thr Leu Trp Ala Arg  Met Ile Leu Gly Gly  Ser Gly Gly 
    1055                 1060                 1065             


Glu Pro  Leu Asp Leu Pro Gln  Ile Ile Gln Arg Leu  His Gly Leu 
    1070                 1075                 1080             


Ser Ala  Phe Ser Leu His Ser  Tyr Ser Pro Gly Glu  Ile Asn Arg 
    1085                 1090                 1095             


Val Ala  Ala Cys Leu Arg Lys  Leu Gly Val Pro Pro  Leu Arg Ala 
    1100                 1105                 1110             


Trp Arg  His Arg Ala Arg Ser  Val Arg Ala 
    1115                 1120             


<210>  119
<211>  1655
<212>  PRT
<213>  Homo sapiens

<400>  119

Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly 
1               5                   10                  15      


Ala Val Phe Val Ser Pro Ser Gln Glu Ile His Ala Arg Phe Arg Arg 
            20                  25                  30          


Lys Gly Gly Gly Pro Gly Gly Gly Lys Ser Thr Asn Pro Lys Pro Gln 
        35                  40                  45              


Arg Lys Thr Lys Arg Asn Thr Asn Arg Arg Pro Gln Asp Val Lys Phe 
    50                  55                  60                  


Pro Gly Gly Gly Gln Ile Val Gly Gly Val Tyr Leu Leu Pro Arg Arg 
65                  70                  75                  80  


Gly Pro Arg Leu Gly Val Arg Ala Thr Arg Lys Thr Ser Glu Arg Ser 
                85                  90                  95      


Gln Pro Arg Gly Arg Arg Gln Pro Ile Pro Lys Ala Arg Arg Pro Glu 
            100                 105                 110         


Gly Arg Thr Trp Ala Gln Pro Gly Tyr Pro Trp Pro Leu Tyr Gly Asn 
        115                 120                 125             


Glu Gly Cys Gly Trp Ala Gly Trp Leu Leu Ser Pro Arg Gly Ser Arg 
    130                 135                 140                 


Pro Ser Trp Gly Pro Thr Asp Pro Arg Arg Arg Ser Arg Asn Leu Gly 
145                 150                 155                 160 


Lys Val Ile Asp Thr Leu Thr Cys Gly Phe Ala Asp Leu Met Gly Tyr 
                165                 170                 175     


Ile Pro Leu Val Gly Ala Pro Leu Gly Gly Ala Ala Arg Ala Leu Ala 
            180                 185                 190         


His Gly Val Arg Val Leu Glu Asp Gly Val Asn Tyr Ala Thr Gly Asn 
        195                 200                 205             


Leu Pro Gly Cys Ser Phe Ser Ile Phe Leu Leu Ala Leu Leu Ser Cys 
    210                 215                 220                 


Leu Thr Val Pro Ala Ser Ala Gly Gly Ser Gly Tyr Val Gly Asp Leu 
225                 230                 235                 240 


Cys Gly Ser Val Phe Leu Val Ser Gln Leu Phe Thr Phe Ser Pro Arg 
                245                 250                 255     


Pro Tyr Pro Gly His Ile Thr Gly His Arg Met Ala Trp Asp Met Met 
            260                 265                 270         


Met Asn Trp Ser Pro Val Cys Gly Pro Val Tyr Cys Phe Thr Pro Ser 
        275                 280                 285             


Pro Val Val Val Gly Thr Thr Asp Arg Thr Asp Val Phe Leu Leu Asn 
    290                 295                 300                 


Asn Thr Arg Pro Pro Leu Gly Asn Trp Phe Gly Cys Thr Trp Met Cys 
305                 310                 315                 320 


Pro Thr Asp Cys Phe Arg Lys His Pro Glu Ala Thr Tyr Ser Arg Cys 
                325                 330                 335     


Gly Ser Gly Pro Trp Leu Thr Pro Arg Cys Leu Val Asp Tyr Pro Tyr 
            340                 345                 350         


Arg Leu Trp Gly Asp Arg Asp Arg Ser Glu Leu Ser Pro Leu Leu Leu 
        355                 360                 365             


Ser Thr Thr Gln Trp Gln Val Leu Pro Cys Ser Phe Thr Thr Leu Pro 
    370                 375                 380                 


Ala Leu Ser Thr Gly Leu Ile His Leu His Gln Asn Ile Val Asp Val 
385                 390                 395                 400 


Gln Tyr Leu Tyr Gly Val Gly Ser Ser Val Ala Arg Val Cys Ala Cys 
                405                 410                 415     


Leu Trp Met Met Leu Leu Ile Ala Gln Ala Glu Ala Ala Leu Glu Asn 
            420                 425                 430         


Leu Val Lys Gly Trp Arg Leu Leu Ala Pro Ile Thr Ala Tyr Ala Gln 
        435                 440                 445             


Gln Thr Arg Gly Leu Leu Gly Cys Ile Ile Thr Ser Leu Thr Gly Arg 
    450                 455                 460                 


Asp Lys Asn Gln Val Glu Gly Glu Val Gln Ile Val Ser Thr Gln Ser 
465                 470                 475                 480 


Phe Leu Ala Thr Cys Ile Asn Gly Val Cys Trp Thr Val Tyr His Gly 
                485                 490                 495     


Ala Gly Pro Cys Thr Cys Gly Ser Ser Asp Leu Tyr Leu Val Thr Arg 
            500                 505                 510         


His Ala Asp Val Ile Pro Val Arg Arg Arg Gly Asp Ser Arg Gly Ser 
        515                 520                 525             


Leu Leu Ser Pro Arg Pro Ile Ser Tyr Leu Lys Gly Ser Ser Gly Gly 
    530                 535                 540                 


Pro Leu Leu Cys Pro Ser Gly His Ala Val Gly Ile Phe Arg Ala Ala 
545                 550                 555                 560 


Val Cys Thr Arg Gly Val Ala Lys Ala Val Asp Phe Ile Pro Val Glu 
                565                 570                 575     


Ser Met Glu Thr Thr Met Arg Ser Pro Val Phe Thr Asp Asn Ser Ser 
            580                 585                 590         


Pro Pro Ala Val Pro Gln Thr Phe Gln Val Ala His Leu His Ala Pro 
        595                 600                 605             


Thr Gly Ser Gly Lys Ser Thr Lys Val Pro Ala Ala Tyr Ala Ala Gln 
    610                 615                 620                 


Gly Tyr Lys Val Leu Val Leu Asn Pro Ser Val Ala Ala Thr Leu Gly 
625                 630                 635                 640 


Phe Gly Ala Tyr Met Ser Lys Ala His Gly Val Ser Gly Thr Gly Val 
                645                 650                 655     


Arg Thr Ile Thr Thr Gly Ser Pro Ile Thr Tyr Ser Thr Tyr Gly Lys 
            660                 665                 670         


Phe Leu Ala Asp Gly Gly Cys Ser Gly Gly Ala Tyr Asp Ile Ile Ile 
        675                 680                 685             


Cys Asp Glu Cys His Ser Thr Asp Ala Thr Ser Ile Leu Gly Ile Gly 
    690                 695                 700                 


Thr Val Leu Asp Gln Ala Glu Thr Ala Gly Ala Arg Leu Val Val Leu 
705                 710                 715                 720 


Ala Thr Ala Thr Pro Pro Gly Ser Val Thr Val Pro His Pro Asn Ile 
                725                 730                 735     


Glu Glu Val Gly Pro Gly Asn Ala Val Ala Tyr Tyr Arg Gly Leu Asp 
            740                 745                 750         


Val Ser Val Ile Pro Thr Ser Gly Asp Val Val Val Val Ala Thr Asp 
        755                 760                 765             


Ala Leu Met Thr Gly Phe Thr Gly Asp Phe Asp Ser Val Ile Asp Cys 
    770                 775                 780                 


Asn Thr Cys Val Thr Gln Thr Val Asp Phe Ser Leu Asp Pro Thr Phe 
785                 790                 795                 800 


Thr Ile Glu Thr Thr Thr Leu Pro Gln Asp Ala Val Ser Arg Thr Gln 
                805                 810                 815     


Arg Arg Gly Arg Thr Gly Arg Gly Arg Pro Gly Gly Gly Ser Gly Gly 
            820                 825                 830         


Gly Tyr Arg Phe Val Thr Pro Gly Glu Arg Pro Ser Gly Met Phe Asp 
        835                 840                 845             


Ser Ser Val Leu Cys Glu Cys Tyr Asp Ala Gly Cys Ala Trp Tyr Glu 
    850                 855                 860                 


Leu Thr Pro Ala Glu Thr Thr Val Arg Leu Arg Ala Tyr Leu Asn Thr 
865                 870                 875                 880 


Pro Gly Leu Pro Val Cys Gln Asp His Leu Glu Phe Trp Glu Gly Val 
                885                 890                 895     


Phe Thr Gly Leu Thr His Ile Asp Ala His Phe Leu Ser Gln Thr Lys 
            900                 905                 910         


Gln Ala Gly Asp Asn Phe Pro Tyr Leu Val Ala Tyr Gln Ala Thr Val 
        915                 920                 925             


Cys Ala Arg Ala Gln Ala Pro Pro Pro Ser Trp Asp Gln Met Trp Lys 
    930                 935                 940                 


Cys Leu Ile Arg Leu Lys Pro Gly Gly Lys Gly Pro Gly Gly Lys Tyr 
945                 950                 955                 960 


Ile Met Thr Cys Met Ser Ala Asp Leu Glu Val Val Thr Ser Thr Trp 
                965                 970                 975     


Val Leu Val Gly Gly Val Leu Ala Ala Leu Ala Ala Tyr Cys Leu Ser 
            980                 985                 990         


Thr Gly Cys Val Val Ile Val Gly  Arg Ile Val Leu Ser  Gly Gly Pro 
        995                 1000                 1005             


Gly Phe  Trp Ala Lys His Met  Trp Asn Phe Ile Ser  Gly Ile Gln 
    1010                 1015                 1020             


Tyr Leu  Ala Gly Leu Ser Thr  Leu Pro Gly Asn Pro  Ala Ile Ala 
    1025                 1030                 1035             


Ser Leu  Met Ala Phe Thr Ala  Ser Val Thr Ser Pro  Leu Thr Thr 
    1040                 1045                 1050             


Gln Pro  Gly Ser Ile Gly Leu  Gly Lys Val Leu Val  Asp Ile Leu 
    1055                 1060                 1065             


Ala Gly  Tyr Gly Ala Gly Val  Ala Gly Ala Leu Val  Ala Phe Lys 
    1070                 1075                 1080             


Ile Met  Ser Gly Glu Val Pro  Ser Thr Glu Asp Leu  Val Asn Leu 
    1085                 1090                 1095             


Leu Pro  Ala Ile Leu Ser Pro  Gly Ala Leu Val Val  Gly Val Val 
    1100                 1105                 1110             


Cys Ala  Ala Ile Leu Arg Arg  His Val Gly Pro Gly  Glu Gly Ala 
    1115                 1120                 1125             


Val Gln  Trp Met Asn Arg Leu  Ile Ala Phe Ala Ser  Arg Gly Asn 
    1130                 1135                 1140             


His Val  Ser Pro Thr His Tyr  Val Pro Glu Ser Asp  Ala Ala Ala 
    1145                 1150                 1155             


Arg Val  Thr Gln Ile Leu Ser  Ser Trp Leu Arg Asp  Ile Trp Asp 
    1160                 1165                 1170             


Trp Ile  Cys Glu Val Leu Ser  Asp Phe Lys Thr Trp  Leu Lys Cys 
    1175                 1180                 1185             


Pro Cys  Gln Val Pro Ser Pro  Glu Phe Phe Thr Glu  Leu Asp Gly 
    1190                 1195                 1200             


Val Arg  Leu His Arg Lys Lys  Gly Pro Gly Ser Gly  Pro Gly Pro 
    1205                 1210                 1215             


Arg Arg  Leu Ala Arg Gly Ser  Pro Pro Ser Leu Ala  Ser Ser Ser 
    1220                 1225                 1230             


Ala Ser  Gln Leu Ser Ala Pro  Ser Leu Lys Ala Thr  Cys Thr Thr 
    1235                 1240                 1245             


Asn His  Ser Asp Ala Glu Ser  Tyr Ser Ser Met Pro  Pro Leu Glu 
    1250                 1255                 1260             


Gly Glu  Pro Gly Asp Pro Asp  Leu Ser Asp Gly Ser  Trp Ser Thr 
    1265                 1270                 1275             


Val Ser  Ser Glu Ala Gly Ser  Gly Ser Leu Ser Asn  Ser Leu Leu 
    1280                 1285                 1290             


Arg His  His Asn Met Val Tyr  Ala Thr Thr Ser Arg  Ser Ala Gly 
    1295                 1300                 1305             


Pro Leu  Thr Pro Pro His Ser  Ala Lys Ser Lys Phe  Gly Tyr Gly 
    1310                 1315                 1320             


Ala Lys  Asp Val Arg Cys His  Ser Gly Ser Gly Gly  Gly Ser Lys 
    1325                 1330                 1335             


Pro Ala  Arg Leu Ile Val Phe  Pro Asp Leu Gly Val  Arg Val Cys 
    1340                 1345                 1350             


Glu Lys  Met Ala Leu Tyr Asp  Val Val Gly Gly Pro  Met Gly Phe 
    1355                 1360                 1365             


Ser Tyr  Asp Thr Arg Cys Phe  Asp Ser Thr Val Thr  Glu Ser Asp 
    1370                 1375                 1380             


Ile Arg  Thr Glu Gly Gly Ser  Gly Gly Gly Ser Leu  Thr Glu Arg 
    1385                 1390                 1395             


Leu Tyr  Val Gly Gly Pro Leu  Thr Asn Ser Lys Gly  Gln Asn Cys 
    1400                 1405                 1410             


Gly Tyr  Arg Arg Cys Arg Ala  Ser Gly Val Leu Thr  Thr Ser Cys 
    1415                 1420                 1425             


Gly Asn  Thr Leu Thr Cys Tyr  Leu Lys Ala Ser Ala  Ala Cys Arg 
    1430                 1435                 1440             


Ala Ala  Lys Leu Gly Gly Ser  Gly Gly Cys Thr Met  Leu Val Cys 
    1445                 1450                 1455             


Gly Asp  Asp Leu Val Val Ile  Cys Glu Ser Ala Gly  Thr Gln Glu 
    1460                 1465                 1470             


Asp Ala  Ser Leu Arg Ala Phe  Thr Glu Ala Met Thr  Arg Tyr Ser 
    1475                 1480                 1485             


Ala Pro  Pro Gly Asp Pro Pro  Gln Pro Glu Tyr Asp  Leu Glu Leu 
    1490                 1495                 1500             


Ile Thr  Ser Cys Ser Ser Asn  Val Ser Val Ala His  Asp Ala Ser 
    1505                 1510                 1515             


Gly Lys  Arg Val Tyr Tyr Leu  Thr Arg Asp Pro Thr  Thr Pro Leu 
    1520                 1525                 1530             


Ala Arg  Ala Ala Trp Glu Thr  Ala Arg His Thr Pro  Val Asn Ser 
    1535                 1540                 1545             


Trp Leu  Gly Asn Ile Ile Met  Tyr Ala Pro Thr Leu  Trp Ala Arg 
    1550                 1555                 1560             


Met Ile  Leu Gly Gly Ser Gly  Gly Glu Pro Leu Asp  Leu Pro Gln 
    1565                 1570                 1575             


Ile Ile  Gln Arg Leu His Gly  Leu Ser Ala Phe Ser  Leu His Ser 
    1580                 1585                 1590             


Tyr Ser  Pro Gly Glu Ile Asn  Arg Val Ala Ala Cys  Leu Arg Lys 
    1595                 1600                 1605             


Leu Gly  Val Pro Pro Leu Arg  Ala Trp Arg His Arg  Ala Arg Ser 
    1610                 1615                 1620             


Val Arg  Ala Ser Gly Gly Arg  Ala Ala Ile Cys Gly  Lys Tyr Leu 
    1625                 1630                 1635             


Phe Asn  Trp Ala Val Arg Thr  Lys Leu Lys Leu Thr  Pro Ile Pro 
    1640                 1645                 1650             


Ala Ala  
    1655 


<210>  120
<211>  1072
<212>  PRT
<213>  Homo sapiens

<400>  120

Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly 
1               5                   10                  15      


Ala Val Phe Val Ser Pro Ser Gln Glu Ile His Ala Arg Phe Arg Arg 
            20                  25                  30          


Lys Gly Gly Gly Pro Gly Gly Gly Lys Ser Thr Asn Pro Lys Pro Gln 
        35                  40                  45              


Arg Lys Thr Lys Arg Asn Thr Asn Arg Arg Pro Gln Asp Val Lys Phe 
    50                  55                  60                  


Pro Gly Gly Gly Gln Ile Val Gly Gly Val Tyr Leu Leu Pro Arg Arg 
65                  70                  75                  80  


Gly Pro Arg Leu Gly Val Arg Ala Thr Arg Lys Thr Ser Glu Arg Ser 
                85                  90                  95      


Gln Pro Arg Gly Arg Arg Gln Pro Ile Pro Lys Ala Arg Arg Pro Glu 
            100                 105                 110         


Gly Arg Ser Trp Ala Gln Pro Gly Tyr Pro Trp Pro Leu Tyr Gly Asn 
        115                 120                 125             


Glu Gly Cys Gly Trp Ala Gly Trp Leu Leu Ser Pro Arg Gly Ser Arg 
    130                 135                 140                 


Pro Ser Trp Gly Pro Thr Asp Pro Arg Arg Arg Ser Arg Asn Leu Gly 
145                 150                 155                 160 


Lys Val Ile Asp Thr Leu Thr Cys Gly Phe Ala Asp Leu Met Gly Tyr 
                165                 170                 175     


Ile Pro Leu Val Gly Ala Pro Leu Gly Gly Ala Ala Arg Ala Leu Ala 
            180                 185                 190         


His Gly Val Arg Val Leu Glu Asp Gly Val Asn Tyr Ala Thr Gly Asn 
        195                 200                 205             


Leu Pro Gly Cys Ser Phe Ser Ile Phe Leu Leu Ala Leu Leu Ser Cys 
    210                 215                 220                 


Leu Thr Val Pro Ala Ser Gly Lys Gly Gly Thr Thr Glu Leu Ala Ile 
225                 230                 235                 240 


Leu Pro Cys Ser Phe Thr Pro Leu Pro Ala Leu Ser Thr Gly Leu Ile 
                245                 250                 255     


His Leu His Gln Asn Ile Val Asp Val Gln Tyr Leu Tyr Gly Val Gly 
            260                 265                 270         


Ser Gly Met Met Gly Trp Arg Leu Leu Ala Pro Ile Thr Ala Tyr Ala 
        275                 280                 285             


Gln Gln Thr Arg Gly Leu Leu Gly Thr Ile Val Thr Ser Leu Thr Gly 
    290                 295                 300                 


Arg Asp Lys Asn Val Val Thr Gly Glu Val Gln Val Leu Ser Thr Ala 
305                 310                 315                 320 


Gly Ser Gly Pro Cys Thr Cys Gly Ser Ala Asp Leu Tyr Leu Val Thr 
                325                 330                 335     


Arg Asp Ala Asp Val Ile Pro Ala Arg Arg Arg Gly Asp Ser Thr Ala 
            340                 345                 350         


Ser Leu Leu Ser Pro Arg Pro Leu Ala Cys Leu Lys Gly Ser Ser Gly 
        355                 360                 365             


Gly Pro Val Met Cys Pro Ser Gly His Val Ala Gly Ile Phe Arg Ala 
    370                 375                 380                 


Ala Val Cys Thr Arg Gly Val Ala Lys Ala Leu Gln Phe Ile Pro Val 
385                 390                 395                 400 


Glu Thr Leu Arg Ser Pro Val Phe Ser Asp Asn Ser Ser Pro Pro Ala 
                405                 410                 415     


Val Pro Gln Ser Tyr Gln Val Ala His Leu His Ala Pro Thr Gly Ser 
            420                 425                 430         


Gly Lys Ser Thr Lys Val Pro Ala Ala Tyr Ala Ala Gln Gly Tyr Lys 
        435                 440                 445             


Val Leu Val Leu Asn Pro Ser Val Ala Ala Thr Leu Gly Phe Gly Ala 
    450                 455                 460                 


Tyr Met Ser Lys Ala Thr Gly Asn Arg Thr Ile Thr Thr Gly Ala Lys 
465                 470                 475                 480 


Leu Thr Tyr Ser Thr Tyr Gly Lys Phe Leu Ala Asp Gly Gly Cys Ser 
                485                 490                 495     


Gly Gly Ala Tyr Asp Val Ile Ile Cys Asp Glu Cys His Ala Gln Asp 
            500                 505                 510         


Ala Thr Ser Ile Leu Gly Ile Gly Thr Val Leu Asp Gln Ala Glu Thr 
        515                 520                 525             


Ala Gly Val Arg Leu Thr Val Leu Ala Thr Ala Thr Pro Pro Gly Ser 
    530                 535                 540                 


Ile Thr Val Pro His Ser Asn Ile Glu Glu Val Ala Leu Ser Val Ile 
545                 550                 555                 560 


Pro Thr Ala Gly Asp Val Val Val Cys Ala Thr Asp Ala Leu Met Thr 
                565                 570                 575     


Gly Phe Thr Gly Asp Phe Asp Ser Val Ile Asp Cys Asn Val Ala Val 
            580                 585                 590         


Glu Gln Tyr Val Asp Phe Ser Leu Asp Pro Thr Phe Ser Ile Glu Thr 
        595                 600                 605             


Arg Thr Ala Pro Gln Asp Ala Val Ser Arg Ser Gln Arg Arg Gly Arg 
    610                 615                 620                 


Thr Gly Arg Gly Arg Leu Gly Thr Tyr Arg Tyr Val Gly Pro Gly Glu 
625                 630                 635                 640 


Arg Pro Ser Gly Met Phe Asp Ser Val Val Leu Cys Glu Cys Tyr Asp 
                645                 650                 655     


Ala Gly Cys Ala Trp Tyr Glu Leu Gln Pro Ala Glu Thr Thr Val Arg 
            660                 665                 670         


Leu Arg Ala Tyr Leu Ser Thr Pro Gly Leu Pro Val Cys Gln Asp His 
        675                 680                 685             


Leu Asp Phe Trp Glu Ser Val Phe Thr Gly Leu Thr His Ile Asp Ala 
    690                 695                 700                 


His Phe Leu Ser Gln Thr Lys Gln Gln Gly Leu Asn Phe Pro Tyr Leu 
705                 710                 715                 720 


Thr Ala Tyr Gln Ala Thr Val Cys Ala Arg Ala Gln Ala Pro Pro Pro 
                725                 730                 735     


Ser Trp Asp Glu Met Trp Lys Cys Leu Val Arg Leu Lys Pro Thr Leu 
            740                 745                 750         


His Gly Pro Thr Pro Leu Leu Tyr Arg Leu Gly Pro Val Gln Asn Gly 
        755                 760                 765             


Gly Ser Gly Lys Gly Gly Ile Gly Ser Val Gly Leu Gly Lys Val Leu 
    770                 775                 780                 


Val Asp Ile Leu Ala Gly Tyr Gly Ala Gly Val Ala Gly Ala Leu Val 
785                 790                 795                 800 


Ala Phe Lys Ile Met Ser Gly Glu Ile Pro Ser Thr Glu Asp Leu Val 
                805                 810                 815     


Asn Leu Leu Pro Ala Ile Leu Ser Pro Gly Ala Leu Val Val Gly Val 
            820                 825                 830         


Val Cys Ala Ala Ile Leu Arg Arg His Val Gly Pro Gly Glu Gly Ala 
        835                 840                 845             


Val Gln Trp Met Asn Arg Leu Ile Ala Phe Ala Ser Arg Gly Asn His 
    850                 855                 860                 


Val Ser Pro Thr His Tyr Val Pro Glu Ser Asp Ala Ala Ala Arg Val 
865                 870                 875                 880 


Thr Ala Ile Leu Ser Ser Leu Thr Ser Gly Gln Ser Val Val Cys Cys 
                885                 890                 895     


Ser Met Ser Tyr Ser Trp Thr Gly Ala Leu Ile Thr Pro Cys Ser Ala 
            900                 905                 910         


Glu Glu Glu Lys Leu Pro Ile Asn Pro Leu Ser Asn Ser Leu Leu Arg 
        915                 920                 925             


His His Asn Leu Val Tyr Ser Thr Ser Ser Arg Ser Ala Ser Gln Arg 
    930                 935                 940                 


Gln Lys Lys Val Thr Phe Asp Arg Leu Gln Val Leu Asp Asp His Tyr 
945                 950                 955                 960 


Lys Lys Gly Lys Arg Tyr Tyr Tyr Leu Thr Arg Asp Pro Thr Thr Pro 
                965                 970                 975     


Leu Ala Arg Ala Ala Trp Glu Thr Ala Arg His Thr Pro Val Asn Ser 
            980                 985                 990         


Trp Leu Gly Asn Ile Ile Met Tyr  Ala Pro Thr Ile Trp  Val Arg Met 
        995                 1000                 1005             


Val Met  Gly Lys Gly Pro Gly  Ser Tyr Gly Ala Thr  Tyr Ser Val 
    1010                 1015                 1020             


Thr Pro  Leu Asp Leu Pro Ala  Ile Ile Glu Arg Leu  His Gly Leu 
    1025                 1030                 1035             


Ser Ala  Phe Thr Leu His Ser  Tyr Ser Pro Val Glu  Leu Asn Arg 
    1040                 1045                 1050             


Val Ala  Gly Thr Leu Arg Lys  Leu Gly Cys Pro Pro  Leu Arg Ala 
    1055                 1060                 1065             


Trp Arg  His Arg 
    1070         


<210>  121
<211>  1554
<212>  PRT
<213>  Homo sapiens

<400>  121

Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly 
1               5                   10                  15      


Ala Val Phe Val Ser Pro Ser Gln Glu Ile His Ala Arg Phe Arg Arg 
            20                  25                  30          


Lys Gly Gly Gly Pro Gly Gly Gly Lys Ser Thr Asn Pro Lys Pro Gln 
        35                  40                  45              


Arg Lys Thr Lys Arg Asn Thr Asn Arg Arg Pro Gln Asp Val Lys Phe 
    50                  55                  60                  


Pro Gly Gly Gly Gln Ile Val Gly Gly Val Tyr Leu Leu Pro Arg Arg 
65                  70                  75                  80  


Gly Pro Arg Leu Gly Val Arg Ala Thr Arg Lys Thr Ser Glu Arg Ser 
                85                  90                  95      


Gln Pro Arg Gly Arg Arg Gln Pro Ile Pro Lys Ala Arg Arg Pro Glu 
            100                 105                 110         


Gly Arg Ser Trp Ala Gln Pro Gly Tyr Pro Trp Pro Leu Tyr Gly Asn 
        115                 120                 125             


Glu Gly Cys Gly Trp Ala Gly Trp Leu Leu Ser Pro Arg Gly Ser Arg 
    130                 135                 140                 


Pro Ser Trp Gly Pro Thr Asp Pro Arg Arg Arg Ser Arg Asn Leu Gly 
145                 150                 155                 160 


Lys Val Ile Asp Thr Leu Thr Cys Gly Phe Ala Asp Leu Met Gly Tyr 
                165                 170                 175     


Ile Pro Leu Val Gly Ala Pro Leu Gly Gly Ala Ala Arg Ala Leu Ala 
            180                 185                 190         


His Gly Val Arg Val Leu Glu Asp Gly Val Asn Tyr Ala Thr Gly Asn 
        195                 200                 205             


Leu Pro Gly Cys Ser Phe Ser Ile Phe Leu Leu Ala Leu Leu Ser Cys 
    210                 215                 220                 


Leu Thr Val Pro Ala Ser Gly Gly Gly Ser Gly Gly Gly Val Asp Leu 
225                 230                 235                 240 


Leu Val Gly Ala Ala Thr Met Cys Ser Ala Leu Tyr Val Gly Asp Met 
                245                 250                 255     


Cys Gly Pro His Trp Gly Val Leu Ala Gly Leu Ala Tyr Tyr Ser Met 
            260                 265                 270         


Gln Gly Asn Trp Ala Lys Val Ser Val Cys Gly Pro Val Tyr Cys Phe 
        275                 280                 285             


Thr Pro Ser Pro Val Val Val Gly Thr Thr Asp Arg Gly Pro Gly Ser 
    290                 295                 300                 


Gly Lys Gly Pro Gly Gly Arg Cys Gly Ser Gly Pro Trp Leu Thr Pro 
305                 310                 315                 320 


Arg Cys Leu Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys Thr 
                325                 330                 335     


Ala Ala Cys Asn Trp Thr Arg Gly Glu Arg Cys Asp Ile Glu Asp Arg 
            340                 345                 350         


Asp Arg Ser Glu Leu Gly Gly Ser Gly Thr Thr Glu Leu Ala Ile Leu 
        355                 360                 365             


Pro Cys Ser Phe Thr Pro Leu Pro Ala Leu Ser Thr Gly Leu Ile His 
    370                 375                 380                 


Leu His Gln Asn Ile Val Asp Val Gln Tyr Leu Tyr Gly Val Gly Ser 
385                 390                 395                 400 


Gly Met Met Gly Trp Arg Leu Leu Ala Pro Ile Thr Ala Tyr Ala Gln 
                405                 410                 415     


Gln Thr Arg Gly Leu Leu Gly Thr Ile Val Thr Ser Leu Thr Gly Arg 
            420                 425                 430         


Asp Lys Asn Val Val Thr Gly Glu Val Gln Val Leu Ser Thr Ala Gly 
        435                 440                 445             


Ser Gly Pro Cys Thr Cys Gly Ser Ala Asp Leu Tyr Leu Val Thr Arg 
    450                 455                 460                 


Asp Ala Asp Val Ile Pro Ala Arg Arg Arg Gly Asp Ser Thr Ala Ser 
465                 470                 475                 480 


Leu Leu Ser Pro Arg Pro Leu Ala Cys Leu Lys Gly Ser Ser Gly Gly 
                485                 490                 495     


Pro Val Met Cys Pro Ser Gly His Val Ala Gly Ile Phe Arg Ala Ala 
            500                 505                 510         


Val Cys Thr Arg Gly Val Ala Lys Ala Leu Gln Phe Ile Pro Val Glu 
        515                 520                 525             


Thr Leu Arg Ser Pro Val Phe Ser Asp Asn Ser Ser Pro Pro Ala Val 
    530                 535                 540                 


Pro Gln Ser Tyr Gln Val Ala His Leu His Ala Pro Thr Gly Ser Gly 
545                 550                 555                 560 


Lys Ser Thr Lys Val Pro Ala Ala Tyr Ala Ala Gln Gly Tyr Lys Val 
                565                 570                 575     


Leu Val Leu Asn Pro Ser Val Ala Ala Thr Leu Gly Phe Gly Ala Tyr 
            580                 585                 590         


Met Ser Lys Ala Thr Gly Asn Arg Thr Ile Thr Thr Gly Ala Lys Leu 
        595                 600                 605             


Thr Tyr Ser Thr Tyr Gly Lys Phe Leu Ala Asp Gly Gly Cys Ser Gly 
    610                 615                 620                 


Gly Ala Tyr Asp Val Ile Ile Cys Asp Glu Cys His Ala Gln Asp Ala 
625                 630                 635                 640 


Thr Ser Ile Leu Gly Ile Gly Thr Val Leu Asp Gln Ala Glu Thr Ala 
                645                 650                 655     


Gly Val Arg Leu Thr Val Leu Ala Thr Ala Thr Pro Pro Gly Ser Ile 
            660                 665                 670         


Thr Val Pro His Ser Asn Ile Glu Glu Val Ala Leu Ser Val Ile Pro 
        675                 680                 685             


Thr Ala Gly Asp Val Val Val Cys Ala Thr Asp Ala Leu Met Thr Gly 
    690                 695                 700                 


Phe Thr Gly Asp Phe Asp Ser Val Ile Asp Cys Asn Val Ala Val Glu 
705                 710                 715                 720 


Gln Tyr Val Asp Phe Ser Leu Asp Pro Thr Phe Ser Ile Glu Thr Arg 
                725                 730                 735     


Thr Ala Pro Gln Asp Ala Val Ser Arg Ser Gln Arg Arg Gly Arg Thr 
            740                 745                 750         


Gly Arg Gly Arg Leu Gly Thr Tyr Arg Tyr Val Gly Pro Gly Glu Arg 
        755                 760                 765             


Pro Ser Gly Met Phe Asp Ser Val Val Leu Cys Glu Cys Tyr Asp Ala 
    770                 775                 780                 


Gly Cys Ala Trp Tyr Glu Leu Gln Pro Ala Glu Thr Thr Val Arg Leu 
785                 790                 795                 800 


Arg Ala Tyr Leu Ser Thr Pro Gly Leu Pro Val Cys Gln Asp His Leu 
                805                 810                 815     


Asp Phe Trp Glu Ser Val Phe Thr Gly Leu Thr His Ile Asp Ala His 
            820                 825                 830         


Phe Leu Ser Gln Thr Lys Gln Gln Gly Leu Asn Phe Pro Tyr Leu Thr 
        835                 840                 845             


Ala Tyr Gln Ala Thr Val Cys Ala Arg Ala Gln Ala Pro Pro Pro Ser 
    850                 855                 860                 


Trp Asp Glu Met Trp Lys Cys Leu Val Arg Leu Lys Pro Thr Leu His 
865                 870                 875                 880 


Gly Pro Thr Pro Leu Leu Tyr Arg Leu Gly Pro Val Gln Asn Gly Pro 
                885                 890                 895     


Pro Met Ala Cys Met Ser Ala Asp Leu Glu Val Thr Thr Ser Thr Trp 
            900                 905                 910         


Val Leu Leu Gly Gly Val Leu Ala Ala Leu Ala Ala Tyr Cys Leu Ser 
        915                 920                 925             


Val Gly Cys Val Val Ile Val Gly His Phe Trp Ala Lys His Met Trp 
    930                 935                 940                 


Asn Phe Ile Ser Gly Ile Gln Tyr Leu Ala Gly Leu Ser Thr Leu Pro 
945                 950                 955                 960 


Gly Asn Pro Ala Ile Ala Ser Leu Met Ala Phe Thr Ala Gly Pro Ile 
                965                 970                 975     


Gly Ser Val Gly Leu Gly Lys Val Leu Val Asp Ile Leu Ala Gly Tyr 
            980                 985                 990         


Gly Ala Gly Val Ala Gly Ala Leu  Val Ala Phe Lys Ile  Met Ser Gly 
        995                 1000                 1005             


Glu Ile  Pro Ser Thr Glu Asp  Leu Val Asn Leu Leu  Pro Ala Ile 
    1010                 1015                 1020             


Leu Ser  Pro Gly Ala Leu Val  Val Gly Val Val Cys  Ala Ala Ile 
    1025                 1030                 1035             


Leu Arg  Arg His Val Gly Pro  Gly Glu Gly Ala Val  Gln Trp Met 
    1040                 1045                 1050             


Asn Arg  Leu Ile Ala Phe Ala  Ser Arg Gly Asn His  Val Ser Pro 
    1055                 1060                 1065             


Thr His  Tyr Val Pro Glu Ser  Asp Ala Ala Ala Arg  Val Thr Ala 
    1070                 1075                 1080             


Ile Leu  Ser Ser Leu Thr Cys  Pro Cys Gln Val Pro  Ala Pro Glu 
    1085                 1090                 1095             


Phe Phe  Thr Glu Val Asp Gly  Val Arg Leu His Arg  Gly Gly Gly 
    1100                 1105                 1110             


Pro Pro  Gly Gly Gly Ile Gly  Ser Gln Leu Pro Cys  Glu Pro Glu 
    1115                 1120                 1125             


Pro Asp  Val Ser Val Leu Thr  Ser Met Leu Pro Thr  Ala Ala Arg 
    1130                 1135                 1140             


Arg Leu  Ala Arg Gly Ser Pro  Pro Ser Glu Ala Ser  Ser Ser Ala 
    1145                 1150                 1155             


Ser Gln  Leu Ser Ala Pro Ser  Leu Lys Ala Thr Cys  Gln Thr His 
    1160                 1165                 1170             


Arg Glu  Ser Asp Ser Glu Ser  Cys Ser Ser Met Pro  Pro Leu Glu 
    1175                 1180                 1185             


Gly Glu  Pro Gly Asp Pro Asp  Leu Ser Cys Asp Ser  Trp Ser Thr 
    1190                 1195                 1200             


Val Ser  Asp Gln Ser Val Val  Cys Cys Ser Met Ser  Tyr Ser Trp 
    1205                 1210                 1215             


Thr Gly  Ala Leu Ile Thr Pro  Cys Ser Ala Glu Glu  Glu Lys Leu 
    1220                 1225                 1230             


Pro Ile  Asn Pro Leu Ser Asn  Ser Leu Leu Arg His  His Asn Leu 
    1235                 1240                 1245             


Val Tyr  Ser Thr Ser Ser Arg  Ser Ala Ser Gln Arg  Gln Lys Lys 
    1250                 1255                 1260             


Val Thr  Phe Asp Arg Leu Gln  Val Leu Asp Asp His  Tyr Lys Gly 
    1265                 1270                 1275             


Pro Gly  Pro Glu Lys Gly Gly  Arg Lys Pro Ala Arg  Leu Ile Val 
    1280                 1285                 1290             


Tyr Pro  Asp Leu Gly Val Arg  Val Cys Glu Lys Met  Ala Leu Tyr 
    1295                 1300                 1305             


Asp Val  Pro Gly Pro Gly Gly  Gly Trp Thr Ser Lys  Lys Thr Pro 
    1310                 1315                 1320             


Met Gly  Phe Ser Tyr Asp Thr  Arg Cys Phe Asp Ser  Thr Val Thr 
    1325                 1330                 1335             


Glu Gln  Asp Ile Arg Val Glu  Glu Glu Gly Pro Cys  Gly Tyr Arg 
    1340                 1345                 1350             


Arg Cys  Arg Ala Ser Gly Val  Leu Thr Thr Ser Cys  Gly Asn Thr 
    1355                 1360                 1365             


Leu Thr  Cys Tyr Ile Lys Ala  Arg Ala Ala Cys Gly  Gly Ser Gly 
    1370                 1375                 1380             


Gly Ala  Leu Arg Ala Phe Thr  Glu Ala Met Thr Arg  Tyr Ser Ala 
    1385                 1390                 1395             


Pro Pro  Gly Asp Ala Pro Gln  Pro Gly Gly Lys Gly  Lys Arg Tyr 
    1400                 1405                 1410             


Tyr Tyr  Leu Thr Arg Asp Pro  Thr Thr Pro Leu Ala  Arg Ala Ala 
    1415                 1420                 1425             


Trp Glu  Thr Ala Arg His Thr  Pro Val Asn Ser Trp  Leu Gly Asn 
    1430                 1435                 1440             


Ile Ile  Met Tyr Ala Pro Thr  Ile Trp Val Arg Met  Val Met Gly 
    1445                 1450                 1455             


Lys Gly  Pro Gly Ser Tyr Gly  Ala Thr Tyr Ser Val  Thr Pro Leu 
    1460                 1465                 1470             


Asp Leu  Pro Ala Ile Ile Glu  Arg Leu His Gly Leu  Ser Ala Phe 
    1475                 1480                 1485             


Thr Leu  His Ser Tyr Ser Pro  Val Glu Leu Asn Arg  Val Ala Gly 
    1490                 1495                 1500             


Thr Leu  Arg Lys Leu Gly Cys  Pro Pro Leu Arg Ala  Trp Arg His 
    1505                 1510                 1515             


Arg Gly  Gly Pro Gly Gly Pro  Gly Gly Val Arg Ala  Lys Leu Leu 
    1520                 1525                 1530             


Ser Gln  Gly Gly Arg Ala Ala  Ile Cys Gly Lys Tyr  Leu Phe Asn 
    1535                 1540                 1545             


Trp Ala  Val Arg Thr Lys 
    1550                 


<210>  122
<211>  1115
<212>  PRT
<213>  Homo sapiens

<400>  122

Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly 
1               5                   10                  15      


Ala Val Phe Val Ser Pro Ser Gln Glu Ile His Ala Arg Phe Arg Arg 
            20                  25                  30          


Lys Gly Gly Gly Pro Gly Gly Gly Thr Lys Arg Asn Thr Asn Arg Arg 
        35                  40                  45              


Pro Met Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly Gly Val 
    50                  55                  60                  


Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala Thr Arg 
65                  70                  75                  80  


Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro Ile Pro 
                85                  90                  95      


Lys Ala Arg Arg Pro Glu Gly Arg Ser Trp Ala Gln Pro Gly Tyr Pro 
            100                 105                 110         


Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp Leu Leu 
        115                 120                 125             


Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Asn Asp Pro Arg Arg 
    130                 135                 140                 


Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys Gly Phe 
145                 150                 155                 160 


Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Ala Pro Val Gly Gly 
                165                 170                 175     


Val Ala Arg Ala Leu Ala His Gly Val Arg Ala Leu Glu Asp Gly Ile 
            180                 185                 190         


Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile Phe Leu 
        195                 200                 205             


Leu Ala Leu Leu Ser Cys Leu Thr Val Pro Ala Ser Cys Pro Thr Asp 
    210                 215                 220                 


Cys Phe Arg Lys His Pro Glu Ala Thr Tyr Thr Lys Cys Gly Ser Gly 
225                 230                 235                 240 


Pro Trp Leu Thr Pro Arg Cys Leu Val Asp Tyr Pro Tyr Arg Leu Trp 
                245                 250                 255     


His Tyr Pro Cys Thr Val Asn Phe Gly Ser Gly Leu Leu Leu Ser Thr 
            260                 265                 270         


Thr Glu Trp Gln Ile Leu Pro Cys Ser Phe Thr Thr Leu Pro Ala Leu 
        275                 280                 285             


Ser Thr Gly Leu Ile His Leu His Gln Asn Ile Val Asp Val Gln Tyr 
    290                 295                 300                 


Leu Tyr Gly Val Gly Ser Gly Pro Pro Cys Thr Cys Gly Ser Ser Asp 
305                 310                 315                 320 


Leu Tyr Leu Val Thr Arg His Ala Asp Val Ile Pro Val Arg Arg Arg 
                325                 330                 335     


Gly Asp Ser Arg Gly Ser Leu Leu Ser Pro Arg Pro Ile Ser Tyr Leu 
            340                 345                 350         


Lys Gly Ser Ser Gly Gly Pro Val Leu Cys Pro Ser Gly His Ala Val 
        355                 360                 365             


Gly Ile Phe Arg Ala Ala Val Cys Thr Arg Gly Val Ala Lys Ala Val 
    370                 375                 380                 


Asp Phe Ile Pro Val Glu Ser Leu Glu Met Arg Ser Pro Val Phe Thr 
385                 390                 395                 400 


Asp Asn Ser Thr Pro Pro Ala Val Pro Gln Thr Tyr Gln Val Ala His 
                405                 410                 415     


Leu His Ala Pro Thr Gly Ser Gly Lys Ser Thr Lys Val Pro Ala Ala 
            420                 425                 430         


Tyr Ala Ala Gln Gly Tyr Lys Val Leu Val Leu Asn Pro Ser Val Ala 
        435                 440                 445             


Ala Thr Leu Gly Phe Gly Ala Tyr Met Ser Lys Ala Tyr Gly Ile Gly 
    450                 455                 460                 


Gly Ser Arg Ser Gly Val Arg Thr Ile Thr Thr Gly Ala Pro Ile Thr 
465                 470                 475                 480 


Tyr Ser Thr Tyr Gly Lys Phe Leu Ala Asp Gly Gly Cys Ser Gly Gly 
                485                 490                 495     


Ala Tyr Asp Ile Ile Ile Cys Asp Glu Cys His Ser Thr Asp Ser Thr 
            500                 505                 510         


Thr Ile Leu Gly Ile Gly Thr Val Leu Asp Gln Ala Glu Thr Ala Gly 
        515                 520                 525             


Val Arg Leu Val Val Leu Ala Thr Ala Thr Pro Pro Gly Gly Asn Ala 
    530                 535                 540                 


Val Ala Tyr Tyr Arg Gly Leu Asp Val Ser Val Ile Pro Thr Ser Gly 
545                 550                 555                 560 


Asp Val Val Val Val Ala Thr Asp Ala Leu Met Thr Gly Phe Thr Gly 
                565                 570                 575     


Asp Phe Asp Ser Val Ile Asp Cys Asn Thr Cys Val Thr Gln Thr Val 
            580                 585                 590         


Asp Phe Ser Leu Asp Pro Thr Phe Thr Ile Glu Thr Thr Thr Val Pro 
        595                 600                 605             


Gln Asp Ala Val Ser Arg Ser Gln Arg Arg Gly Arg Thr Gly Arg Gly 
    610                 615                 620                 


Arg Arg Gly Ile Tyr Arg Phe Val Thr Pro Gly Glu Arg Pro Ser Gly 
625                 630                 635                 640 


Met Phe Asp Ser Ser Val Leu Cys Glu Cys Tyr Asp Ala Gly Cys Ala 
                645                 650                 655     


Trp Tyr Glu Leu Thr Pro Ala Glu Thr Ser Val Arg Leu Arg Ala Tyr 
            660                 665                 670         


Leu Asn Thr Pro Gly Leu Pro Val Cys Gln Asp His Leu Glu Phe Trp 
        675                 680                 685             


Glu Gly Val Phe Thr Gly Leu Thr His Ile Asp Ala His Phe Leu Ser 
    690                 695                 700                 


Gln Thr Lys Gln Ala Gly Asp Asn Phe Pro Tyr Leu Val Ala Tyr Gln 
705                 710                 715                 720 


Ala Thr Val Cys Ala Arg Ala Gln Ala Pro Pro Pro Ser Trp Asp Gln 
                725                 730                 735     


Met Trp Thr His Pro Ile Thr Lys Tyr Ile Met Ala Cys Met Ser Ala 
            740                 745                 750         


Asp Leu Glu Val Val Thr Ser Thr Trp Val Leu Val Gly Gly Val Leu 
        755                 760                 765             


Ala Ala Leu Ala Ala Tyr Cys Leu Ser Val Gly Ser Val Val Ile Val 
    770                 775                 780                 


Gly Gly Pro Gly Phe Trp Ala Lys His Met Trp Asn Phe Ile Ser Gly 
785                 790                 795                 800 


Ile Gln Tyr Leu Ala Gly Leu Ser Thr Leu Pro Gly Asn Pro Ala Ile 
                805                 810                 815     


Ala Ser Leu Met Ala Phe Thr Ala Ala Val Thr Ser Pro Leu Gly Ala 
            820                 825                 830         


Ala Val Gly Ser Val Gly Leu Gly Lys Val Leu Val Asp Ile Leu Ala 
        835                 840                 845             


Gly Tyr Gly Ala Gly Val Ala Gly Ala Leu Val Ala Phe Lys Ile Met 
    850                 855                 860                 


Ser Gly Glu Val Pro Ser Thr Glu Asp Leu Val Asn Leu Leu Pro Ala 
865                 870                 875                 880 


Ile Leu Ser Pro Gly Ala Leu Val Val Gly Val Val Cys Ala Ala Ile 
                885                 890                 895     


Leu Arg Arg His Val Gly Pro Gly Glu Gly Ala Val Gln Trp Met Asn 
            900                 905                 910         


Arg Leu Ile Ala Phe Ala Ser Arg Gly Asn His Val Ser Pro Thr His 
        915                 920                 925             


Tyr Val Pro Glu Ser Asp Ala Ala Ala Arg Val Gly Gly Gly Ser Gly 
    930                 935                 940                 


Gly Gly Val Cys Cys Ser Met Ser Tyr Ser Trp Thr Gly Ala Leu Ile 
945                 950                 955                 960 


Thr Pro Cys Ala Ala Glu Glu Glu Lys Leu Pro Ile Asn Pro Leu Ser 
                965                 970                 975     


Asn Ser Leu Ile Arg His His Asn Met Val Tyr Ser Thr Thr Ser Arg 
            980                 985                 990         


Ser Ala Ser Leu Arg Gln Lys Lys  Val Thr Phe Asp Arg  Gly Gly Gly 
        995                 1000                 1005             


Lys Gly  Gly Gly Pro Thr Pro  Leu Ala Arg Ala Ala  Trp Glu Thr 
    1010                 1015                 1020             


Ala Arg  His Thr Pro Val Asn  Ser Trp Leu Gly Asn  Ile Ile Met 
    1025                 1030                 1035             


Tyr Ala  Pro Thr Ile Trp Val  Arg Met Val Leu Met  Thr His Phe 
    1040                 1045                 1050             


Phe Ser  Ile Leu Gln Gly Gly  Gly Ser Gly Gly Pro  Glu Leu Asn 
    1055                 1060                 1065             


Arg Val  Gly Ala Cys Leu Arg  Lys Leu Gly Val Pro  Pro Leu Arg 
    1070                 1075                 1080             


Ala Trp  Arg His Arg Ala Arg  Ala Val Arg Ala Lys  Leu Ile Ala 
    1085                 1090                 1095             


Gln Gly  Gly Lys Ala Ala Ile  Cys Gly Lys Tyr Leu  Phe Asn Trp 
    1100                 1105                 1110             


Ala Val  
    1115 


<210>  123
<211>  1453
<212>  PRT
<213>  Homo sapiens

<400>  123

Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly 
1               5                   10                  15      


Ala Val Phe Val Ser Pro Ser Gln Glu Ile His Ala Arg Phe Arg Arg 
            20                  25                  30          


Lys Gly Gly Gly Pro Gly Gly Gly Thr Lys Arg Asn Thr Asn Arg Arg 
        35                  40                  45              


Pro Met Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly Gly Val 
    50                  55                  60                  


Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala Thr Arg 
65                  70                  75                  80  


Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro Ile Pro 
                85                  90                  95      


Lys Ala Arg Arg Pro Glu Gly Arg Ser Trp Ala Gln Pro Gly Tyr Pro 
            100                 105                 110         


Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp Leu Leu 
        115                 120                 125             


Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Asn Asp Pro Arg Arg 
    130                 135                 140                 


Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys Gly Phe 
145                 150                 155                 160 


Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Ala Pro Val Gly Gly 
                165                 170                 175     


Val Ala Arg Ala Leu Ala His Gly Val Arg Ala Leu Glu Asp Gly Ile 
            180                 185                 190         


Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile Phe Leu 
        195                 200                 205             


Leu Ala Leu Leu Ser Cys Leu Thr Val Pro Ala Ser Pro Gly Cys Asn 
    210                 215                 220                 


Cys Ser Ile Tyr Pro Gly His Ile Thr Gly His Arg Met Ala Trp Asp 
225                 230                 235                 240 


Met Met Met Asn Trp Ser Pro Thr Thr Lys Lys Asn Gly Ser Trp His 
                245                 250                 255     


Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Ser Leu Asn Thr Gly Phe 
            260                 265                 270         


Ile Gly Pro Gly Gly Ser Val Cys Gly Pro Val Tyr Cys Phe Thr Pro 
        275                 280                 285             


Ser Pro Val Val Val Gly Thr Thr Asp Arg Gly Pro Gly Cys Pro Thr 
    290                 295                 300                 


Asp Cys Phe Arg Lys His Pro Glu Ala Thr Tyr Thr Lys Cys Gly Ser 
305                 310                 315                 320 


Gly Pro Trp Leu Thr Pro Arg Cys Leu Val Asp Tyr Pro Tyr Arg Leu 
                325                 330                 335     


Trp His Tyr Pro Cys Thr Val Asn Phe Gly Ser Gly Leu Leu Leu Ser 
            340                 345                 350         


Thr Thr Glu Trp Gln Ile Leu Pro Cys Ser Phe Thr Thr Leu Pro Ala 
        355                 360                 365             


Leu Ser Thr Gly Leu Ile His Leu His Gln Asn Ile Val Asp Val Gln 
    370                 375                 380                 


Tyr Leu Tyr Gly Val Gly Ser Met Gly Trp Arg Leu Leu Ala Pro Ile 
385                 390                 395                 400 


Thr Ala Tyr Ala Gln Gln Thr Arg Gly Leu Leu Gly Thr Ile Val Thr 
                405                 410                 415     


Ser Leu Thr Gly Arg Asp Lys Asn Pro Cys Thr Cys Gly Ser Ser Asp 
            420                 425                 430         


Leu Tyr Leu Val Thr Arg His Ala Asp Val Ile Pro Val Arg Arg Arg 
        435                 440                 445             


Gly Asp Ser Arg Gly Ser Leu Leu Ser Pro Arg Pro Ile Ser Tyr Leu 
    450                 455                 460                 


Lys Gly Ser Ser Gly Gly Pro Val Leu Cys Pro Ser Gly His Ala Val 
465                 470                 475                 480 


Gly Ile Phe Arg Ala Ala Val Cys Thr Arg Gly Val Ala Lys Ala Val 
                485                 490                 495     


Asp Phe Ile Pro Val Glu Ser Leu Glu Met Arg Ser Pro Val Phe Thr 
            500                 505                 510         


Asp Asn Ser Thr Pro Pro Ala Val Pro Gln Thr Tyr Gln Val Ala His 
        515                 520                 525             


Leu His Ala Pro Thr Gly Ser Gly Lys Ser Thr Lys Val Pro Ala Ala 
    530                 535                 540                 


Tyr Ala Ala Gln Gly Tyr Lys Val Leu Val Leu Asn Pro Ser Val Ala 
545                 550                 555                 560 


Ala Thr Leu Gly Phe Gly Ala Tyr Met Ser Lys Ala Tyr Gly Ile Gly 
                565                 570                 575     


Gly Ser Arg Ser Gly Val Arg Thr Ile Thr Thr Gly Ala Pro Ile Thr 
            580                 585                 590         


Tyr Ser Thr Tyr Gly Lys Phe Leu Ala Asp Gly Gly Cys Ser Gly Gly 
        595                 600                 605             


Ala Tyr Asp Ile Ile Ile Cys Asp Glu Cys His Ser Thr Asp Ser Thr 
    610                 615                 620                 


Thr Ile Leu Gly Ile Gly Thr Val Leu Asp Gln Ala Glu Thr Ala Gly 
625                 630                 635                 640 


Val Arg Leu Val Val Leu Ala Thr Ala Thr Pro Pro Gly Gly Lys Gly 
                645                 650                 655     


Gly Lys Gly Ile Lys Gly Gly Arg His Leu Ile Phe Cys His Ser Lys 
            660                 665                 670         


Lys Lys Cys Asp Glu Leu Ala Gly Pro Gly Asn Ala Val Ala Tyr Tyr 
        675                 680                 685             


Arg Gly Leu Asp Val Ser Val Ile Pro Thr Ser Gly Asp Val Val Val 
    690                 695                 700                 


Val Ala Thr Asp Ala Leu Met Thr Gly Phe Thr Gly Asp Phe Asp Ser 
705                 710                 715                 720 


Val Ile Asp Cys Asn Thr Cys Val Thr Gln Thr Val Asp Phe Ser Leu 
                725                 730                 735     


Asp Pro Thr Phe Thr Ile Glu Thr Thr Thr Val Pro Gln Asp Ala Val 
            740                 745                 750         


Ser Arg Ser Gln Arg Arg Gly Arg Thr Gly Arg Gly Arg Arg Gly Ile 
        755                 760                 765             


Tyr Arg Phe Val Thr Pro Gly Glu Arg Pro Ser Gly Met Phe Asp Ser 
    770                 775                 780                 


Ser Val Leu Cys Glu Cys Tyr Asp Ala Gly Cys Ala Trp Tyr Glu Leu 
785                 790                 795                 800 


Thr Pro Ala Glu Thr Ser Val Arg Leu Arg Ala Tyr Leu Asn Thr Pro 
                805                 810                 815     


Gly Leu Pro Val Cys Gln Asp His Leu Glu Phe Trp Glu Gly Val Phe 
            820                 825                 830         


Thr Gly Leu Thr His Ile Asp Ala His Phe Leu Ser Gln Thr Lys Gln 
        835                 840                 845             


Ala Gly Asp Asn Phe Pro Tyr Leu Val Ala Tyr Gln Ala Thr Val Cys 
    850                 855                 860                 


Ala Arg Ala Gln Ala Pro Pro Pro Ser Trp Asp Gln Met Trp Thr His 
865                 870                 875                 880 


Pro Ile Thr Lys Tyr Ile Met Ala Cys Met Ser Ala Asp Leu Glu Val 
                885                 890                 895     


Val Thr Ser Thr Trp Val Leu Val Gly Gly Val Leu Ala Ala Leu Ala 
            900                 905                 910         


Ala Tyr Cys Leu Ser Val Gly Ser Val Val Ile Val Gly Gly Pro Gly 
        915                 920                 925             


Phe Trp Ala Lys His Met Trp Asn Phe Ile Ser Gly Ile Gln Tyr Leu 
    930                 935                 940                 


Ala Gly Leu Ser Thr Leu Pro Gly Asn Pro Ala Ile Ala Ser Leu Met 
945                 950                 955                 960 


Ala Phe Thr Ala Ala Val Thr Ser Pro Leu Gly Ala Ala Val Gly Ser 
                965                 970                 975     


Val Gly Leu Gly Lys Val Leu Val Asp Ile Leu Ala Gly Tyr Gly Ala 
            980                 985                 990         


Gly Val Ala Gly Ala Leu Val Ala  Phe Lys Ile Met Ser  Gly Glu Val 
        995                 1000                 1005             


Pro Ser  Thr Glu Asp Leu Val  Asn Leu Leu Pro Ala  Ile Leu Ser 
    1010                 1015                 1020             


Pro Gly  Ala Leu Val Val Gly  Val Val Cys Ala Ala  Ile Leu Arg 
    1025                 1030                 1035             


Arg His  Val Gly Pro Gly Glu  Gly Ala Val Gln Trp  Met Asn Arg 
    1040                 1045                 1050             


Leu Ile  Ala Phe Ala Ser Arg  Gly Asn His Val Ser  Pro Thr His 
    1055                 1060                 1065             


Tyr Val  Pro Glu Ser Asp Ala  Ala Ala Arg Val Gly  Pro Thr Ala 
    1070                 1075                 1080             


Glu Thr  Ala Ala Arg Arg Leu  Ala Arg Gly Ser Pro  Pro Ser Leu 
    1085                 1090                 1095             


Ala Ser  Ser Ser Ala Ser Gln  Leu Ser Ala Pro Ser  Leu Lys Ala 
    1100                 1105                 1110             


Thr Cys  Thr Val Cys Cys Ser  Met Ser Tyr Ser Trp  Thr Gly Ala 
    1115                 1120                 1125             


Leu Ile  Thr Pro Cys Ala Ala  Glu Glu Glu Lys Leu  Pro Ile Asn 
    1130                 1135                 1140             


Pro Leu  Ser Asn Ser Leu Ile  Arg His His Asn Met  Val Tyr Ser 
    1145                 1150                 1155             


Thr Thr  Ser Arg Ser Ala Ser  Leu Arg Gln Lys Lys  Val Thr Phe 
    1160                 1165                 1170             


Asp Arg  Gly Gly Ser Gly Gly  Pro Gly Pro Ser Lys  Gly Gly Arg 
    1175                 1180                 1185             


Lys Pro  Ala Arg Leu Ile Val  Tyr Pro Asp Leu Gly  Val Arg Val 
    1190                 1195                 1200             


Cys Glu  Lys Arg Ala Leu Tyr  Asp Val Pro Gly Gly  Pro Lys Lys 
    1205                 1210                 1215             


Thr Pro  Met Gly Phe Ser Tyr  Asp Thr Arg Cys Phe  Asp Ser Thr 
    1220                 1225                 1230             


Val Thr  Glu Arg Asp Ile Arg  Thr Glu Gly Gly Gly  Pro Gly Gly 
    1235                 1240                 1245             


Cys Gly  Tyr Arg Arg Cys Arg  Ala Ser Gly Val Leu  Thr Thr Ser 
    1250                 1255                 1260             


Met Gly  Asn Thr Ile Thr Cys  Tyr Ile Lys Ala Leu  Ala Ala Glu 
    1265                 1270                 1275             


Ala Met  Thr Arg Tyr Ser Ala  Pro Pro Gly Asp Pro  Pro Gln Pro 
    1280                 1285                 1290             


Glu Tyr  Asp Leu Glu Leu Ile  Thr Ser Cys Ser Ser  Asn Val Ser 
    1295                 1300                 1305             


Val Ala  His Asp Gly Gly Ser  Gly Gly Thr Pro Leu  Ala Arg Ala 
    1310                 1315                 1320             


Ala Trp  Glu Thr Ala Arg His  Thr Pro Val Asn Ser  Trp Leu Gly 
    1325                 1330                 1335             


Asn Ile  Ile Met Tyr Ala Pro  Thr Ile Trp Val Arg  Met Val Leu 
    1340                 1345                 1350             


Met Thr  His Phe Phe Ser Ile  Leu Gln Gly Gly Pro  Gly Tyr Gly 
    1355                 1360                 1365             


Ala Thr  Tyr Ser Val Thr Pro  Leu Asp Leu Pro Ala  Ile Ile Glu 
    1370                 1375                 1380             


Arg Leu  His Gly Leu Ser Ala  Phe Thr Leu His Ser  Tyr Ser Gly 
    1385                 1390                 1395             


Gly Pro  Gly Gly Pro Glu Leu  Asn Arg Val Gly Ala  Cys Leu Arg 
    1400                 1405                 1410             


Lys Leu  Gly Val Pro Pro Leu  Arg Ala Trp Arg His  Arg Ala Arg 
    1415                 1420                 1425             


Ala Val  Arg Ala Lys Leu Ile  Ala Gln Gly Gly Lys  Ala Ala Ile 
    1430                 1435                 1440             


Cys Gly  Lys Tyr Leu Phe Asn  Trp Ala Val 
    1445                 1450             


<210>  124
<211>  1390
<212>  PRT
<213>  Homo sapiens

<400>  124

Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly 
1               5                   10                  15      


Ala Val Phe Val Ser Pro Ser Gln Glu Ile His Ala Arg Phe Arg Arg 
            20                  25                  30          


Lys Gly Gly Gly Pro Gly Gly Gly Thr Lys Arg Asn Thr Asn Arg Arg 
        35                  40                  45              


Pro Met Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly Gly Val 
    50                  55                  60                  


Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala Thr Arg 
65                  70                  75                  80  


Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro Ile Pro 
                85                  90                  95      


Lys Ala Arg Arg Pro Glu Gly Arg Ser Trp Ala Gln Pro Gly Tyr Pro 
            100                 105                 110         


Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp Leu Leu 
        115                 120                 125             


Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Asn Asp Pro Arg Arg 
    130                 135                 140                 


Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys Gly Phe 
145                 150                 155                 160 


Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Ala Pro Val Gly Gly 
                165                 170                 175     


Val Ala Arg Ala Leu Ala His Gly Val Arg Ala Leu Glu Asp Gly Ile 
            180                 185                 190         


Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile Phe Leu 
        195                 200                 205             


Leu Ala Leu Leu Ser Cys Leu Thr Val Pro Ala Ser Cys Asn Cys Ser 
    210                 215                 220                 


Ile Tyr Pro Gly His Ile Thr Gly His Arg Met Ala Trp Asp Met Met 
225                 230                 235                 240 


Met Asn Trp Ser Pro Thr Thr Asn Gly Ser Trp His Ile Asn Arg Thr 
                245                 250                 255     


Ala Leu Asn Cys Asn Asp Ser Leu Asn Thr Gly Phe Ile Ser Val Cys 
            260                 265                 270         


Gly Pro Val Tyr Cys Phe Thr Pro Ser Pro Val Val Val Gly Thr Thr 
        275                 280                 285             


Asp Arg Cys Pro Thr Asp Cys Phe Arg Lys His Pro Glu Ala Thr Tyr 
    290                 295                 300                 


Thr Lys Cys Gly Ser Gly Pro Trp Leu Thr Pro Arg Cys Leu Val Asp 
305                 310                 315                 320 


Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys Thr Val Asn Phe Leu Leu 
                325                 330                 335     


Leu Ser Thr Thr Glu Trp Gln Ile Leu Pro Cys Ser Phe Thr Thr Leu 
            340                 345                 350         


Pro Ala Leu Ser Thr Gly Leu Ile His Leu His Gln Asn Ile Val Asp 
        355                 360                 365             


Val Gln Tyr Leu Tyr Gly Val Gly Ser Met Gly Trp Arg Leu Leu Ala 
    370                 375                 380                 


Pro Ile Thr Ala Tyr Ala Gln Gln Thr Arg Gly Leu Leu Gly Thr Ile 
385                 390                 395                 400 


Val Thr Ser Leu Thr Gly Arg Asp Lys Asn Pro Cys Thr Cys Gly Ser 
                405                 410                 415     


Ser Asp Leu Tyr Leu Val Thr Arg His Ala Asp Val Ile Pro Val Arg 
            420                 425                 430         


Arg Arg Gly Asp Ser Arg Gly Ser Leu Leu Ser Pro Arg Pro Ile Ser 
        435                 440                 445             


Tyr Leu Lys Gly Ser Ser Gly Gly Pro Val Leu Cys Pro Ser Gly His 
    450                 455                 460                 


Ala Val Gly Ile Phe Arg Ala Ala Val Cys Thr Arg Gly Val Ala Lys 
465                 470                 475                 480 


Ala Val Asp Phe Ile Pro Val Glu Ser Leu Glu Met Arg Ser Pro Val 
                485                 490                 495     


Phe Thr Asp Asn Ser Thr Pro Pro Ala Val Pro Gln Thr Tyr Gln Val 
            500                 505                 510         


Ala His Leu His Ala Pro Thr Gly Ser Gly Lys Ser Thr Lys Val Pro 
        515                 520                 525             


Ala Ala Tyr Ala Ala Gln Gly Tyr Lys Val Leu Val Leu Asn Pro Ser 
    530                 535                 540                 


Val Ala Ala Thr Leu Gly Phe Gly Ala Tyr Met Ser Lys Ala Tyr Gly 
545                 550                 555                 560 


Ile Arg Ser Gly Val Arg Thr Ile Thr Thr Gly Ala Pro Ile Thr Tyr 
                565                 570                 575     


Ser Thr Tyr Gly Lys Phe Leu Ala Asp Gly Gly Cys Ser Gly Gly Ala 
            580                 585                 590         


Tyr Asp Ile Ile Ile Cys Asp Glu Cys His Ser Thr Asp Ser Thr Thr 
        595                 600                 605             


Ile Leu Gly Ile Gly Thr Val Leu Asp Gln Ala Glu Thr Ala Gly Val 
    610                 615                 620                 


Arg Leu Val Val Leu Ala Thr Ala Thr Pro Pro Gly Ile Lys Gly Gly 
625                 630                 635                 640 


Arg His Leu Ile Phe Cys His Ser Lys Lys Lys Cys Asp Glu Leu Ala 
                645                 650                 655     


Asn Ala Val Ala Tyr Tyr Arg Gly Leu Asp Val Ser Val Ile Pro Thr 
            660                 665                 670         


Ser Gly Asp Val Val Val Val Ala Thr Asp Ala Leu Met Thr Gly Phe 
        675                 680                 685             


Thr Gly Asp Phe Asp Ser Val Ile Asp Cys Asn Thr Cys Val Thr Gln 
    690                 695                 700                 


Thr Val Asp Phe Ser Leu Asp Pro Thr Phe Thr Ile Glu Thr Thr Thr 
705                 710                 715                 720 


Val Pro Gln Asp Ala Val Ser Arg Ser Gln Arg Arg Gly Arg Thr Gly 
                725                 730                 735     


Arg Gly Arg Arg Gly Ile Tyr Arg Phe Val Thr Pro Gly Glu Arg Pro 
            740                 745                 750         


Ser Gly Met Phe Asp Ser Ser Val Leu Cys Glu Cys Tyr Asp Ala Gly 
        755                 760                 765             


Cys Ala Trp Tyr Glu Leu Thr Pro Ala Glu Thr Ser Val Arg Leu Arg 
    770                 775                 780                 


Ala Tyr Leu Asn Thr Pro Gly Leu Pro Val Cys Gln Asp His Leu Glu 
785                 790                 795                 800 


Phe Trp Glu Gly Val Phe Thr Gly Leu Thr His Ile Asp Ala His Phe 
                805                 810                 815     


Leu Ser Gln Thr Lys Gln Ala Gly Asp Asn Phe Pro Tyr Leu Val Ala 
            820                 825                 830         


Tyr Gln Ala Thr Val Cys Ala Arg Ala Gln Ala Pro Pro Pro Ser Trp 
        835                 840                 845             


Asp Gln Met Trp Thr His Pro Ile Thr Lys Tyr Ile Met Ala Cys Met 
    850                 855                 860                 


Ser Ala Asp Leu Glu Val Val Thr Ser Thr Trp Val Leu Val Gly Gly 
865                 870                 875                 880 


Val Leu Ala Ala Leu Ala Ala Tyr Cys Leu Ser Val Gly Ser Val Val 
                885                 890                 895     


Ile Val Gly Phe Trp Ala Lys His Met Trp Asn Phe Ile Ser Gly Ile 
            900                 905                 910         


Gln Tyr Leu Ala Gly Leu Ser Thr Leu Pro Gly Asn Pro Ala Ile Ala 
        915                 920                 925             


Ser Leu Met Ala Phe Thr Ala Ala Val Thr Ser Pro Leu Gly Ala Ala 
    930                 935                 940                 


Val Gly Ser Val Gly Leu Gly Lys Val Leu Val Asp Ile Leu Ala Gly 
945                 950                 955                 960 


Tyr Gly Ala Gly Val Ala Gly Ala Leu Val Ala Phe Lys Ile Met Ser 
                965                 970                 975     


Gly Glu Val Pro Ser Thr Glu Asp Leu Val Asn Leu Leu Pro Ala Ile 
            980                 985                 990         


Leu Ser Pro Gly Ala Leu Val Val  Gly Val Val Cys Ala  Ala Ile Leu 
        995                 1000                 1005             


Arg Arg  His Val Gly Pro Gly  Glu Gly Ala Val Gln  Trp Met Asn 
    1010                 1015                 1020             


Arg Leu  Ile Ala Phe Ala Ser  Arg Gly Asn His Val  Ser Pro Thr 
    1025                 1030                 1035             


His Tyr  Val Pro Glu Ser Asp  Ala Ala Ala Arg Val  Thr Ala Glu 
    1040                 1045                 1050             


Thr Ala  Ala Arg Arg Leu Ala  Arg Gly Ser Pro Pro  Ser Leu Ala 
    1055                 1060                 1065             


Ser Ser  Ser Ala Ser Gln Leu  Ser Ala Pro Ser Leu  Lys Ala Thr 
    1070                 1075                 1080             


Cys Thr  Val Cys Cys Ser Met  Ser Tyr Ser Trp Thr  Gly Ala Leu 
    1085                 1090                 1095             


Ile Thr  Pro Cys Ala Ala Glu  Glu Glu Lys Leu Pro  Ile Asn Pro 
    1100                 1105                 1110             


Leu Ser  Asn Ser Leu Ile Arg  His His Asn Met Val  Tyr Ser Thr 
    1115                 1120                 1125             


Thr Ser  Arg Ser Ala Ser Leu  Arg Gln Lys Lys Val  Thr Phe Asp 
    1130                 1135                 1140             


Arg Pro  Ser Lys Gly Gly Arg  Lys Pro Ala Arg Leu  Ile Val Tyr 
    1145                 1150                 1155             


Pro Asp  Leu Gly Val Arg Val  Cys Glu Lys Arg Ala  Leu Tyr Asp 
    1160                 1165                 1170             


Val Lys  Lys Thr Pro Met Gly  Phe Ser Tyr Asp Thr  Arg Cys Phe 
    1175                 1180                 1185             


Asp Ser  Thr Val Thr Glu Arg  Asp Ile Arg Thr Glu  Cys Gly Tyr 
    1190                 1195                 1200             


Arg Arg  Cys Arg Ala Ser Gly  Val Leu Thr Thr Ser  Met Gly Asn 
    1205                 1210                 1215             


Thr Ile  Thr Cys Tyr Ile Lys  Ala Leu Ala Ala Glu  Ala Met Thr 
    1220                 1225                 1230             


Arg Tyr  Ser Ala Pro Pro Gly  Asp Pro Pro Gln Pro  Glu Tyr Asp 
    1235                 1240                 1245             


Leu Glu  Leu Ile Thr Ser Cys  Ser Ser Asn Val Ser  Val Ala His 
    1250                 1255                 1260             


Asp Thr  Pro Leu Ala Arg Ala  Ala Trp Glu Thr Ala  Arg His Thr 
    1265                 1270                 1275             


Pro Val  Asn Ser Trp Leu Gly  Asn Ile Ile Met Tyr  Ala Pro Thr 
    1280                 1285                 1290             


Ile Trp  Val Arg Met Val Leu  Met Thr His Phe Phe  Ser Ile Leu 
    1295                 1300                 1305             


Gln Tyr  Gly Ala Thr Tyr Ser  Val Thr Pro Leu Asp  Leu Pro Ala 
    1310                 1315                 1320             


Ile Ile  Glu Arg Leu His Gly  Leu Ser Ala Phe Thr  Leu His Ser 
    1325                 1330                 1335             


Tyr Ser  Glu Leu Asn Arg Val  Gly Ala Cys Leu Arg  Lys Leu Gly 
    1340                 1345                 1350             


Val Pro  Pro Leu Arg Ala Trp  Arg His Arg Ala Arg  Ala Val Arg 
    1355                 1360                 1365             


Ala Lys  Leu Ile Ala Gln Gly  Gly Lys Ala Ala Ile  Cys Gly Lys 
    1370                 1375                 1380             


Tyr Leu  Phe Asn Trp Ala Val  
    1385                 1390 


<210>  125
<211>  1414
<212>  PRT
<213>  Homo sapiens

<400>  125

Met Thr Lys Arg Asn Thr Asn Arg Arg Pro Met Asp Val Lys Phe Pro 
1               5                   10                  15      


Gly Gly Gly Gln Ile Val Gly Gly Val Tyr Leu Leu Pro Arg Arg Gly 
            20                  25                  30          


Pro Arg Leu Gly Val Arg Ala Thr Arg Lys Thr Ser Glu Arg Ser Gln 
        35                  40                  45              


Pro Arg Gly Arg Arg Gln Pro Ile Pro Lys Ala Arg Arg Pro Glu Gly 
    50                  55                  60                  


Arg Ser Trp Ala Gln Pro Gly Tyr Pro Trp Pro Leu Tyr Gly Asn Glu 
65                  70                  75                  80  


Gly Cys Gly Trp Ala Gly Trp Leu Leu Ser Pro Arg Gly Ser Arg Pro 
                85                  90                  95      


Ser Trp Gly Pro Asn Asp Pro Arg Arg Arg Ser Arg Asn Leu Gly Lys 
            100                 105                 110         


Val Ile Asp Thr Leu Thr Cys Gly Phe Ala Asp Leu Met Gly Tyr Ile 
        115                 120                 125             


Pro Leu Val Gly Ala Pro Val Gly Gly Val Ala Arg Ala Leu Ala His 
    130                 135                 140                 


Gly Val Arg Ala Leu Glu Asp Gly Ile Asn Tyr Ala Thr Gly Asn Leu 
145                 150                 155                 160 


Pro Gly Cys Ser Phe Ser Ile Phe Leu Leu Ala Leu Leu Ser Cys Leu 
                165                 170                 175     


Thr Val Pro Ala Ser Pro Gly Cys Asn Cys Ser Ile Tyr Pro Gly His 
            180                 185                 190         


Ile Thr Gly His Arg Met Ala Trp Asp Met Met Met Asn Trp Ser Pro 
        195                 200                 205             


Thr Thr Lys Lys Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn 
    210                 215                 220                 


Cys Asn Asp Ser Leu Asn Thr Gly Phe Ile Gly Pro Gly Gly Ser Val 
225                 230                 235                 240 


Cys Gly Pro Val Tyr Cys Phe Thr Pro Ser Pro Val Val Val Gly Thr 
                245                 250                 255     


Thr Asp Arg Gly Pro Gly Cys Pro Thr Asp Cys Phe Arg Lys His Pro 
            260                 265                 270         


Glu Ala Thr Tyr Thr Lys Cys Gly Ser Gly Pro Trp Leu Thr Pro Arg 
        275                 280                 285             


Cys Leu Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys Thr Val 
    290                 295                 300                 


Asn Phe Gly Ser Gly Leu Leu Leu Ser Thr Thr Glu Trp Gln Ile Leu 
305                 310                 315                 320 


Pro Cys Ser Phe Thr Thr Leu Pro Ala Leu Ser Thr Gly Leu Ile His 
                325                 330                 335     


Leu His Gln Asn Ile Val Asp Val Gln Tyr Leu Tyr Gly Val Gly Ser 
            340                 345                 350         


Met Gly Trp Arg Leu Leu Ala Pro Ile Thr Ala Tyr Ala Gln Gln Thr 
        355                 360                 365             


Arg Gly Leu Leu Gly Thr Ile Val Thr Ser Leu Thr Gly Arg Asp Lys 
    370                 375                 380                 


Asn Pro Cys Thr Cys Gly Ser Ser Asp Leu Tyr Leu Val Thr Arg His 
385                 390                 395                 400 


Ala Asp Val Ile Pro Val Arg Arg Arg Gly Asp Ser Arg Gly Ser Leu 
                405                 410                 415     


Leu Ser Pro Arg Pro Ile Ser Tyr Leu Lys Gly Ser Ser Gly Gly Pro 
            420                 425                 430         


Val Leu Cys Pro Ser Gly His Ala Val Gly Ile Phe Arg Ala Ala Val 
        435                 440                 445             


Cys Thr Arg Gly Val Ala Lys Ala Val Asp Phe Ile Pro Val Glu Ser 
    450                 455                 460                 


Leu Glu Met Arg Ser Pro Val Phe Thr Asp Asn Ser Thr Pro Pro Ala 
465                 470                 475                 480 


Val Pro Gln Thr Tyr Gln Val Ala His Leu His Ala Pro Thr Gly Ser 
                485                 490                 495     


Gly Lys Ser Thr Lys Val Pro Ala Ala Tyr Ala Ala Gln Gly Tyr Lys 
            500                 505                 510         


Val Leu Val Leu Asn Pro Ser Val Ala Ala Thr Leu Gly Phe Gly Ala 
        515                 520                 525             


Tyr Met Ser Lys Ala Tyr Gly Ile Gly Gly Ser Arg Ser Gly Val Arg 
    530                 535                 540                 


Thr Ile Thr Thr Gly Ala Pro Ile Thr Tyr Ser Thr Tyr Gly Lys Phe 
545                 550                 555                 560 


Leu Ala Asp Gly Gly Cys Ser Gly Gly Ala Tyr Asp Ile Ile Ile Cys 
                565                 570                 575     


Asp Glu Cys His Ser Thr Asp Ser Thr Thr Ile Leu Gly Ile Gly Thr 
            580                 585                 590         


Val Leu Asp Gln Ala Glu Thr Ala Gly Val Arg Leu Val Val Leu Ala 
        595                 600                 605             


Thr Ala Thr Pro Pro Gly Gly Lys Gly Gly Lys Gly Ile Lys Gly Gly 
    610                 615                 620                 


Arg His Leu Ile Phe Cys His Ser Lys Lys Lys Cys Asp Glu Leu Ala 
625                 630                 635                 640 


Gly Pro Gly Asn Ala Val Ala Tyr Tyr Arg Gly Leu Asp Val Ser Val 
                645                 650                 655     


Ile Pro Thr Ser Gly Asp Val Val Val Val Ala Thr Asp Ala Leu Met 
            660                 665                 670         


Thr Gly Phe Thr Gly Asp Phe Asp Ser Val Ile Asp Cys Asn Thr Cys 
        675                 680                 685             


Val Thr Gln Thr Val Asp Phe Ser Leu Asp Pro Thr Phe Thr Ile Glu 
    690                 695                 700                 


Thr Thr Thr Val Pro Gln Asp Ala Val Ser Arg Ser Gln Arg Arg Gly 
705                 710                 715                 720 


Arg Thr Gly Arg Gly Arg Arg Gly Ile Tyr Arg Phe Val Thr Pro Gly 
                725                 730                 735     


Glu Arg Pro Ser Gly Met Phe Asp Ser Ser Val Leu Cys Glu Cys Tyr 
            740                 745                 750         


Asp Ala Gly Cys Ala Trp Tyr Glu Leu Thr Pro Ala Glu Thr Ser Val 
        755                 760                 765             


Arg Leu Arg Ala Tyr Leu Asn Thr Pro Gly Leu Pro Val Cys Gln Asp 
    770                 775                 780                 


His Leu Glu Phe Trp Glu Gly Val Phe Thr Gly Leu Thr His Ile Asp 
785                 790                 795                 800 


Ala His Phe Leu Ser Gln Thr Lys Gln Ala Gly Asp Asn Phe Pro Tyr 
                805                 810                 815     


Leu Val Ala Tyr Gln Ala Thr Val Cys Ala Arg Ala Gln Ala Pro Pro 
            820                 825                 830         


Pro Ser Trp Asp Gln Met Trp Thr His Pro Ile Thr Lys Tyr Ile Met 
        835                 840                 845             


Ala Cys Met Ser Ala Asp Leu Glu Val Val Thr Ser Thr Trp Val Leu 
    850                 855                 860                 


Val Gly Gly Val Leu Ala Ala Leu Ala Ala Tyr Cys Leu Ser Val Gly 
865                 870                 875                 880 


Ser Val Val Ile Val Gly Gly Pro Gly Phe Trp Ala Lys His Met Trp 
                885                 890                 895     


Asn Phe Ile Ser Gly Ile Gln Tyr Leu Ala Gly Leu Ser Thr Leu Pro 
            900                 905                 910         


Gly Asn Pro Ala Ile Ala Ser Leu Met Ala Phe Thr Ala Ala Val Thr 
        915                 920                 925             


Ser Pro Leu Gly Ala Ala Val Gly Ser Val Gly Leu Gly Lys Val Leu 
    930                 935                 940                 


Val Asp Ile Leu Ala Gly Tyr Gly Ala Gly Val Ala Gly Ala Leu Val 
945                 950                 955                 960 


Ala Phe Lys Ile Met Ser Gly Glu Val Pro Ser Thr Glu Asp Leu Val 
                965                 970                 975     


Asn Leu Leu Pro Ala Ile Leu Ser Pro Gly Ala Leu Val Val Gly Val 
            980                 985                 990         


Val Cys Ala Ala Ile Leu Arg Arg  His Val Gly Pro Gly  Glu Gly Ala 
        995                 1000                 1005             


Val Gln  Trp Met Asn Arg Leu  Ile Ala Phe Ala Ser  Arg Gly Asn 
    1010                 1015                 1020             


His Val  Ser Pro Thr His Tyr  Val Pro Glu Ser Asp  Ala Ala Ala 
    1025                 1030                 1035             


Arg Val  Gly Pro Thr Ala Glu  Thr Ala Ala Arg Arg  Leu Ala Arg 
    1040                 1045                 1050             


Gly Ser  Pro Pro Ser Leu Ala  Ser Ser Ser Ala Ser  Gln Leu Ser 
    1055                 1060                 1065             


Ala Pro  Ser Leu Lys Ala Thr  Cys Thr Val Cys Cys  Ser Met Ser 
    1070                 1075                 1080             


Tyr Ser  Trp Thr Gly Ala Leu  Ile Thr Pro Cys Ala  Ala Glu Glu 
    1085                 1090                 1095             


Glu Lys  Leu Pro Ile Asn Pro  Leu Ser Asn Ser Leu  Ile Arg His 
    1100                 1105                 1110             


His Asn  Met Val Tyr Ser Thr  Thr Ser Arg Ser Ala  Ser Leu Arg 
    1115                 1120                 1125             


Gln Lys  Lys Val Thr Phe Asp  Arg Gly Gly Ser Gly  Gly Pro Gly 
    1130                 1135                 1140             


Pro Ser  Lys Gly Gly Arg Lys  Pro Ala Arg Leu Ile  Val Tyr Pro 
    1145                 1150                 1155             


Asp Leu  Gly Val Arg Val Cys  Glu Lys Arg Ala Leu  Tyr Asp Val 
    1160                 1165                 1170             


Pro Gly  Gly Pro Lys Lys Thr  Pro Met Gly Phe Ser  Tyr Asp Thr 
    1175                 1180                 1185             


Arg Cys  Phe Asp Ser Thr Val  Thr Glu Arg Asp Ile  Arg Thr Glu 
    1190                 1195                 1200             


Gly Gly  Gly Pro Gly Gly Cys  Gly Tyr Arg Arg Cys  Arg Ala Ser 
    1205                 1210                 1215             


Gly Val  Leu Thr Thr Ser Met  Gly Asn Thr Ile Thr  Cys Tyr Ile 
    1220                 1225                 1230             


Lys Ala  Leu Ala Ala Glu Ala  Met Thr Arg Tyr Ser  Ala Pro Pro 
    1235                 1240                 1245             


Gly Asp  Pro Pro Gln Pro Glu  Tyr Asp Leu Glu Leu  Ile Thr Ser 
    1250                 1255                 1260             


Cys Ser  Ser Asn Val Ser Val  Ala His Asp Gly Gly  Ser Gly Gly 
    1265                 1270                 1275             


Thr Pro  Leu Ala Arg Ala Ala  Trp Glu Thr Ala Arg  His Thr Pro 
    1280                 1285                 1290             


Val Asn  Ser Trp Leu Gly Asn  Ile Ile Met Tyr Ala  Pro Thr Ile 
    1295                 1300                 1305             


Trp Val  Arg Met Val Leu Met  Thr His Phe Phe Ser  Ile Leu Gln 
    1310                 1315                 1320             


Gly Gly  Pro Gly Tyr Gly Ala  Thr Tyr Ser Val Thr  Pro Leu Asp 
    1325                 1330                 1335             


Leu Pro  Ala Ile Ile Glu Arg  Leu His Gly Leu Ser  Ala Phe Thr 
    1340                 1345                 1350             


Leu His  Ser Tyr Ser Gly Gly  Pro Gly Gly Pro Glu  Leu Asn Arg 
    1355                 1360                 1365             


Val Gly  Ala Cys Leu Arg Lys  Leu Gly Val Pro Pro  Leu Arg Ala 
    1370                 1375                 1380             


Trp Arg  His Arg Ala Arg Ala  Val Arg Ala Lys Leu  Ile Ala Gln 
    1385                 1390                 1395             


Gly Gly  Lys Ala Ala Ile Cys  Gly Lys Tyr Leu Phe  Asn Trp Ala 
    1400                 1405                 1410             


Val 
    


<210>  126
<211>  180
<212>  PRT
<213>  Homo sapiens


<220>
<221>  VARIANT
<222>  (65)..(65)
<223>  X is T or S

<220>
<221>  VARIANT
<222>  (100)..(100)
<223>  X is T or N

<220>
<221>  VARIANT
<222>  (134)..(134)
<223>  X is L or V

<220>
<221>  VARIANT
<222>  (137)..(137)
<223>  X is A or V

<220>
<221>  VARIANT
<222>  (147)..(147)
<223>  X is V or A

<220>
<221>  VARIANT
<222>  (152)..(152)
<223>  X is V or I

<220>
<221>  VARIANT
<222>  (154)..(154)
<223>  X is Y or F

<220>
<221>  VARIANT
<222>  (177)..(177)
<223>  X is V or H

<400>  126

Thr Lys Arg Asn Thr Asn Arg Arg Pro Gln Asp Val Lys Phe Pro Gly 
1               5                   10                  15      


Gly Gly Gln Ile Val Gly Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro 
            20                  25                  30          


Arg Leu Gly Val Arg Ala Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro 
        35                  40                  45              


Arg Gly Arg Arg Gln Pro Ile Pro Lys Ala Arg Arg Pro Glu Gly Arg 
    50                  55                  60                  


Xaa Trp Ala Gln Pro Gly Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly 
65                  70                  75                  80  


Cys Gly Trp Ala Gly Trp Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser 
                85                  90                  95      


Trp Gly Pro Xaa Asp Pro Arg Arg Arg Ser Arg Asn Leu Gly Lys Val 
            100                 105                 110         


Ile Asp Thr Leu Thr Cys Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro 
        115                 120                 125             


Leu Val Gly Ala Pro Xaa Gly Gly Xaa Ala Arg Ala Leu Ala His Gly 
    130                 135                 140                 


Val Arg Xaa Leu Glu Asp Gly Xaa Asn Xaa Ala Thr Gly Asn Leu Pro 
145                 150                 155                 160 


Gly Cys Ser Phe Ser Ile Phe Leu Leu Ala Leu Leu Ser Cys Leu Thr 
                165                 170                 175     


Xaa Pro Ala Ser 
            180 


<210>  127
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  127

Val Cys Gly Pro Val Tyr Cys Phe Thr Pro Ser Pro Val Val Val Gly 
1               5                   10                  15      


Thr Thr Asp Arg 
            20  


<210>  128
<211>  21
<212>  PRT
<213>  Homo sapiens


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  X is R or K

<400>  128

Xaa Cys Gly Ser Gly Pro Trp Leu Thr Pro Arg Cys Leu Val Asp Tyr 
1               5                   10                  15      


Pro Tyr Arg Leu Trp 
            20      


<210>  129
<211>  39
<212>  PRT
<213>  Homo sapiens


<220>
<221>  VARIANT
<222>  (4)..(4)
<223>  X is W or L

<220>
<221>  VARIANT
<222>  (5)..(5)
<223>  X is Q or A

<220>
<221>  VARIANT
<222>  (6)..(6)
<223>  X is V or I

<220>
<221>  VARIANT
<222>  (13)..(13)
<223>  X is T or P

<400>  129

Thr Thr Glu Xaa Xaa Xaa Leu Pro Cys Ser Phe Thr Xaa Leu Pro Ala 
1               5                   10                  15      


Leu Ser Thr Gly Leu Ile His Leu His Gln Asn Ile Val Asp Val Gln 
            20                  25                  30          


Tyr Leu Tyr Gly Val Gly Ser 
        35                  


<210>  130
<211>  33
<212>  PRT
<213>  Homo sapiens


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  X is Q or M or K

<220>
<221>  VARIANT
<222>  (22)..(22)
<223>  X is C or T

<220>
<221>  VARIANT
<222>  (24)..(24)
<223>  X is I or V

<400>  130

Xaa Gly Trp Arg Leu Leu Ala Pro Ile Thr Ala Tyr Ala Gln Gln Thr 
1               5                   10                  15      


Arg Gly Leu Leu Gly Xaa Ile Xaa Thr Ser Leu Thr Gly Arg Asp Lys 
            20                  25                  30          


Asn 
    


<210>  131
<211>  80
<212>  PRT
<213>  Homo sapiens


<220>
<221>  VARIANT
<222>  (21)..(21)
<223>  X is V or A

<220>
<221>  VARIANT
<222>  (29)..(29)
<223>  X is G or A

<220>
<221>  VARIANT
<222>  (37)..(37)
<223>  X is I or L

<220>
<221>  VARIANT
<222>  (38)..(38)
<223>  X is S or A

<220>
<221>  VARIANT
<222>  (39)..(39)
<223>  X is Y or T

<220>
<221>  VARIANT
<222>  (48)..(48)
<223>  X is L or V

<220>
<221>  VARIANT
<222>  (55)..(55)
<223>  X is A or V

<220>
<221>  VARIANT
<222>  (56)..(56)
<223>  X is A or V

<220>
<221>  VARIANT
<222>  (72)..(72)
<223>  X is V or L

<220>
<221>  VARIANT
<222>  (73)..(73)
<223>  X is D or Q

<220>
<221>  VARIANT
<222>  (79)..(79)
<223>  X is S or T

<400>  131

Pro Cys Thr Cys Gly Ser Ser Asp Leu Tyr Leu Val Thr Arg His Ala 
1               5                   10                  15      


Asp Val Ile Pro Xaa Arg Arg Arg Gly Asp Ser Arg Xaa Ser Leu Leu 
            20                  25                  30          


Ser Pro Arg Pro Xaa Xaa Xaa Leu Lys Gly Ser Ser Gly Gly Pro Xaa 
        35                  40                  45              


Leu Cys Pro Ser Gly His Xaa Xaa Gly Ile Phe Arg Ala Ala Val Cys 
    50                  55                  60                  


Thr Arg Gly Val Ala Lys Ala Xaa Xaa Phe Ile Pro Val Glu Xaa Leu 
65                  70                  75                  80  


<210>  132
<211>  66
<212>  PRT
<213>  Homo sapiens


<220>
<221>  VARIANT
<222>  (4)..(4)
<223>  X is V or S

<220>
<221>  VARIANT
<222>  (6)..(6)
<223>  X is T or S

<220>
<221>  VARIANT
<222>  (10)..(10)
<223>  X is S or T

<220>
<221>  VARIANT
<222>  (17)..(17)
<223>  X is T or S

<220>
<221>  VARIANT
<222>  (18)..(18)
<223>  X is F or Y

<220>
<221>  VARIANT
<222>  (21)..(21)
<223>  X is A or G

<400>  132

Arg Ser Pro Xaa Phe Xaa Asp Asn Ser Xaa Pro Pro Ala Val Pro Gln 
1               5                   10                  15      


Xaa Xaa Gln Val Xaa His Leu His Ala Pro Thr Gly Ser Gly Lys Ser 
            20                  25                  30          


Thr Lys Val Pro Ala Ala Tyr Ala Ala Gln Gly Tyr Lys Val Leu Val 
        35                  40                  45              


Leu Asn Pro Ser Val Ala Ala Thr Leu Gly Phe Gly Ala Tyr Met Ser 
    50                  55                  60                  


Lys Ala 
65      


<210>  133
<211>  74
<212>  PRT
<213>  Homo sapiens


<220>
<221>  VARIANT
<222>  (3)..(3)
<223>  X is V or N

<220>
<221>  VARIANT
<222>  (6)..(6)
<223>  X is I or V

<220>
<221>  VARIANT
<222>  (11)..(11)
<223>  X is P or K

<220>
<221>  VARIANT
<222>  (42)..(42)
<223>  X is T or Q

<220>
<221>  VARIANT
<222>  (46)..(46)
<223>  X is S or T

<220>
<221>  VARIANT
<222>  (62)..(62)
<223>  X is A or V

<220>
<221>  VARIANT
<222>  (65)..(65)
<223>  X is V or T

<400>  133

Thr Gly Xaa Arg Thr Xaa Thr Thr Gly Ala Xaa Ile Thr Tyr Ser Thr 
1               5                   10                  15      


Tyr Gly Lys Phe Leu Ala Asp Gly Gly Cys Ser Gly Gly Ala Tyr Asp 
            20                  25                  30          


Ile Ile Ile Cys Asp Glu Cys His Ser Xaa Asp Ala Thr Xaa Ile Leu 
        35                  40                  45              


Gly Ile Gly Thr Val Leu Asp Gln Ala Glu Thr Ala Gly Xaa Arg Leu 
    50                  55                  60                  


Xaa Val Leu Ala Thr Ala Thr Pro Pro Gly 
65                  70                  


<210>  134
<211>  72
<212>  PRT
<213>  Homo sapiens


<220>
<221>  VARIANT
<222>  (12)..(12)
<223>  X is V or C

<220>
<221>  VARIANT
<222>  (33)..(33)
<223>  X is T or V

<220>
<221>  VARIANT
<222>  (34)..(34)
<223>  X is C or A

<220>
<221>  VARIANT
<222>  (36)..(36)
<223>  X is T or E

<220>
<221>  VARIANT
<222>  (48)..(48)
<223>  X is T or S

<220>
<221>  VARIANT
<222>  (54)..(54)
<223>  X is L or A

<220>
<221>  VARIANT
<222>  (62)..(62)
<223>  X is T or S

<400>  134

Ser Val Ile Pro Thr Ser Gly Asp Val Val Val Xaa Ala Thr Asp Ala 
1               5                   10                  15      


Leu Met Thr Gly Phe Thr Gly Asp Phe Asp Ser Val Ile Asp Cys Asn 
            20                  25                  30          


Xaa Xaa Val Xaa Gln Thr Val Asp Phe Ser Leu Asp Pro Thr Phe Xaa 
        35                  40                  45              


Ile Glu Thr Thr Thr Xaa Pro Gln Asp Ala Val Ser Arg Xaa Gln Arg 
    50                  55                  60                  


Arg Gly Arg Thr Gly Arg Gly Arg 
65                  70          


<210>  135
<211>  110
<212>  PRT
<213>  Homo sapiens


<220>
<221>  VARIANT
<222>  (3)..(3)
<223>  X is F or Y

<220>
<221>  VARIANT
<222>  (5)..(5)
<223>  X is T or S

<220>
<221>  VARIANT
<222>  (17)..(17)
<223>  X is S or V

<220>
<221>  VARIANT
<222>  (33)..(33)
<223>  X is T or Q

<220>
<221>  VARIANT
<222>  (62)..(62)
<223>  X is G or S

<220>
<221>  VARIANT
<222>  (81)..(81)
<223>  X is A or Q or G

<220>
<221>  VARIANT
<222>  (83)..(83)
<223>  X is E or L

<220>
<221>  VARIANT
<222>  (100)..(100)
<223>  X is Q or K

<220>
<221>  VARIANT
<222>  (108)..(108)
<223>  X is Q or E or T

<400>  135

Tyr Arg Xaa Val Xaa Pro Gly Glu Arg Pro Ser Gly Met Phe Asp Ser 
1               5                   10                  15      


Xaa Val Leu Cys Glu Cys Tyr Asp Ala Gly Cys Ala Trp Tyr Glu Leu 
            20                  25                  30          


Xaa Pro Ala Glu Thr Thr Val Arg Leu Arg Ala Tyr Leu Asn Thr Pro 
        35                  40                  45              


Gly Leu Pro Val Cys Gln Asp His Leu Glu Phe Trp Glu Xaa Val Phe 
    50                  55                  60                  


Thr Gly Leu Thr His Ile Asp Ala His Phe Leu Ser Gln Thr Lys Gln 
65                  70                  75                  80  


Xaa Gly Xaa Asn Phe Pro Tyr Leu Val Ala Tyr Gln Ala Thr Val Cys 
                85                  90                  95      


Ala Arg Ala Xaa Ala Pro Pro Pro Ser Trp Asp Xaa Met Trp 
            100                 105                 110 


<210>  136
<211>  39
<212>  PRT
<213>  Homo sapiens


<220>
<221>  VARIANT
<222>  (2)..(2)
<223>  X is T or A

<220>
<221>  VARIANT
<222>  (11)..(11)
<223>  X is V or T

<220>
<221>  VARIANT
<222>  (18)..(18)
<223>  X is V or L

<220>
<221>  VARIANT
<222>  (32)..(32)
<223>  X is T or V

<400>  136

Met Xaa Cys Met Ser Ala Asp Leu Glu Val Xaa Thr Ser Thr Trp Val 
1               5                   10                  15      


Leu Xaa Gly Gly Val Leu Ala Ala Leu Ala Ala Tyr Cys Leu Ser Xaa 
            20                  25                  30          


Gly Cys Val Val Ile Val Gly 
        35                  


<210>  137
<211>  36
<212>  PRT
<213>  Homo sapiens


<220>
<221>  VARIANT
<222>  (28)..(28)
<223>  X is I or V

<400>  137

Phe Trp Ala Lys His Met Trp Asn Phe Ile Ser Gly Ile Gln Tyr Leu 
1               5                   10                  15      


Ala Gly Leu Ser Thr Leu Pro Gly Asn Pro Ala Xaa Ala Ser Leu Met 
            20                  25                  30          


Ala Phe Thr Ala 
        35      


<210>  138
<211>  105
<212>  PRT
<213>  Homo sapiens


<220>
<221>  VARIANT
<222>  (31)..(31)
<223>  X is S or G

<220>
<221>  VARIANT
<222>  (34)..(34)
<223>  X is V or L or K

<220>
<221>  VARIANT
<222>  (40)..(40)
<223>  X is L or M

<400>  138

Gly Ser Ile Gly Leu Gly Lys Val Leu Val Asp Ile Leu Ala Gly Tyr 
1               5                   10                  15      


Gly Ala Gly Val Ala Gly Ala Leu Val Ala Phe Lys Ile Met Xaa Gly 
            20                  25                  30          


Glu Xaa Pro Ser Thr Glu Asp Xaa Val Asn Leu Leu Pro Ala Ile Leu 
        35                  40                  45              


Ser Pro Gly Ala Leu Val Val Gly Val Val Cys Ala Ala Ile Leu Arg 
    50                  55                  60                  


Arg His Val Gly Pro Gly Glu Gly Ala Val Gln Trp Met Asn Arg Leu 
65                  70                  75                  80  


Ile Ala Phe Ala Ser Arg Gly Asn His Val Ser Pro Thr His Tyr Val 
                85                  90                  95      


Pro Glu Ser Asp Ala Ala Ala Arg Val 
            100                 105 


<210>  139
<211>  29
<212>  PRT
<213>  Homo sapiens


<220>
<221>  VARIANT
<222>  (11)..(11)
<223>  X is L or E

<220>
<221>  VARIANT
<222>  (29)..(29)
<223>  X is T or Q

<400>  139

Arg Arg Leu Ala Arg Gly Ser Pro Pro Ser Xaa Ala Ser Ser Ser Ala 
1               5                   10                  15      


Ser Gln Leu Ser Ala Pro Ser Leu Lys Ala Thr Cys Xaa 
            20                  25                  


<210>  140
<211>  26
<212>  PRT
<213>  Homo sapiens


<220>
<221>  VARIANT
<222>  (3)..(3)
<223>  X is Y or C

<220>
<221>  VARIANT
<222>  (19)..(19)
<223>  X is S or E

<220>
<221>  VARIANT
<222>  (20)..(20)
<223>  X is D or F

<220>
<221>  VARIANT
<222>  (21)..(21)
<223>  X is G or E

<220>
<221>  VARIANT
<222>  (22)..(22)
<223>  X is S or Q

<220>
<221>  VARIANT
<222>  (23)..(23)
<223>  X is W or V

<220>
<221>  VARIANT
<222>  (24)..(24)
<223>  X is S or E

<220>
<221>  VARIANT
<222>  (25)..(25)
<223>  X is T or S

<220>
<221>  VARIANT
<222>  (26)..(26)
<223>  X is V or Q

<400>  140

Glu Ser Xaa Ser Ser Met Pro Pro Leu Glu Gly Glu Pro Gly Asp Pro 
1               5                   10                  15      


Asp Leu Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25      


<210>  141
<211>  20
<212>  PRT
<213>  Homo sapiens


<220>
<221>  VARIANT
<222>  (11)..(11)
<223>  X is M or L

<220>
<221>  VARIANT
<222>  (14)..(14)
<223>  X is A or S

<220>
<221>  VARIANT
<222>  (16)..(16)
<223>  X is T or S

<400>  141

Leu Ser Asn Ser Leu Leu Arg His His Asn Xaa Val Tyr Xaa Thr Xaa 
1               5                   10                  15      


Ser Arg Ser Ala 
            20  


<210>  142
<211>  24
<212>  PRT
<213>  Homo sapiens


<220>
<221>  VARIANT
<222>  (8)..(8)
<223>  X is F or Y

<220>
<221>  VARIANT
<222>  (19)..(19)
<223>  X is M or R

<400>  142

Lys Pro Ala Arg Leu Ile Val Xaa Pro Asp Leu Gly Val Arg Val Cys 
1               5                   10                  15      


Glu Lys Xaa Ala Leu Tyr Asp Val 
            20                  


<210>  143
<211>  23
<212>  PRT
<213>  Homo sapiens


<220>
<221>  VARIANT
<222>  (18)..(18)
<223>  X is S or Q or R

<220>
<221>  VARIANT
<222>  (22)..(22)
<223>  X is T or V

<400>  143

Pro Met Gly Phe Ser Tyr Asp Thr Arg Cys Phe Asp Ser Thr Val Thr 
1               5                   10                  15      


Glu Xaa Asp Ile Arg Xaa Glu 
            20              


<210>  144
<211>  29
<212>  PRT
<213>  Homo sapiens


<220>
<221>  VARIANT
<222>  (13)..(13)
<223>  X is T or P

<220>
<221>  VARIANT
<222>  (16)..(16)
<223>  X is C or M

<220>
<221>  VARIANT
<222>  (24)..(24)
<223>  X is L or I

<220>
<221>  VARIANT
<222>  (27)..(27)
<223>  X is S or T or L

<400>  144

Cys Gly Tyr Arg Arg Cys Arg Ala Ser Gly Val Leu Xaa Thr Ser Xaa 
1               5                   10                  15      


Gly Asn Thr Leu Thr Cys Tyr Xaa Lys Ala Xaa Ala Ala 
            20                  25                  


<210>  145
<211>  16
<212>  PRT
<213>  Homo sapiens


<220>
<221>  VARIANT
<222>  (13)..(13)
<223>  X is P or A

<400>  145

Glu Ala Met Thr Arg Tyr Ser Ala Pro Pro Gly Asp Xaa Pro Gln Pro 
1               5                   10                  15      


<210>  146
<211>  36
<212>  PRT
<213>  Homo sapiens


<220>
<221>  VARIANT
<222>  (26)..(26)
<223>  X is F or Y

<220>
<221>  VARIANT
<222>  (30)..(30)
<223>  X is L or |

<220>
<221>  VARIANT
<222>  (32)..(32)
<223>  X is A or V

<220>
<221>  VARIANT
<222>  (35)..(35)
<223>  X is I or V

<400>  146

Thr Pro Leu Ala Arg Ala Ala Trp Glu Thr Ala Arg His Thr Pro Val 
1               5                   10                  15      


Asn Ser Trp Leu Gly Asn Ile Ile Met Xaa Ala Pro Thr Xaa Trp Xaa 
            20                  25                  30          


Arg Met Xaa Leu 
        35      


<210>  147
<211>  24
<212>  PRT
<213>  Homo sapiens


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  X is E or T

<220>
<221>  VARIANT
<222>  (7)..(7)
<223>  X is Q or A

<220>
<221>  VARIANT
<222>  (10)..(10)
<223>  X is Q or E

<400>  147

Xaa Pro Leu Asp Leu Pro Xaa Ile Ile Xaa Arg Leu His Gly Leu Ser 
1               5                   10                  15      


Ala Phe Ser Leu His Ser Tyr Ser 
            20                  


<210>  148
<211>  23
<212>  PRT
<213>  Homo sapiens


<220>
<221>  VARIANT
<222>  (2)..(2)
<223>  X is I or L

<220>
<221>  VARIANT
<222>  (7)..(7)
<223>  X is A or G

<220>
<221>  VARIANT
<222>  (14)..(14)
<223>  X is V or C

<400>  148

Glu Xaa Asn Arg Val Ala Xaa Cys Leu Arg Lys Leu Gly Xaa Pro Pro 
1               5                   10                  15      


Leu Arg Ala Trp Arg His Arg 
            20              


<210>  149
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  149

Gly Gly Arg Ala Ala Ile Cys Gly Lys Tyr Leu Phe Asn Trp Ala Val 
1               5                   10                  15      


<210>  150
<211>  64
<212>  PRT
<213>  Homo sapiens

<400>  150

Thr Lys Arg Asn Thr Asn Arg Arg Pro Gln Asp Val Lys Phe Pro Gly 
1               5                   10                  15      


Gly Gly Gln Ile Val Gly Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro 
            20                  25                  30          


Arg Leu Gly Val Arg Ala Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro 
        35                  40                  45              


Arg Gly Arg Arg Gln Pro Ile Pro Lys Ala Arg Arg Pro Glu Gly Arg 
    50                  55                  60                  


<210>  151
<211>  34
<212>  PRT
<213>  Homo sapiens

<400>  151

Trp Ala Gln Pro Gly Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys 
1               5                   10                  15      


Gly Trp Ala Gly Trp Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp 
            20                  25                  30          


Gly Pro 
        


<210>  152
<211>  33
<212>  PRT
<213>  Homo sapiens

<400>  152

Asp Pro Arg Arg Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu 
1               5                   10                  15      


Thr Cys Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Ala 
            20                  25                  30          


Pro 
    


<210>  153
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  153

Ala Arg Ala Leu Ala His Gly Val Arg 
1               5                   


<210>  154
<211>  22
<212>  PRT
<213>  Homo sapiens

<400>  154

Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile Phe Leu Leu Ala 
1               5                   10                  15      


Leu Leu Ser Cys Leu Thr 
            20          


<210>  155
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  155

Val Cys Gly Pro Val Tyr Cys Phe Thr Pro Ser Pro Val Val Val Gly 
1               5                   10                  15      


Thr Thr Asp Arg 
            20  


<210>  156
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  156

Cys Gly Ser Gly Pro Trp Leu Thr Pro Arg Cys Leu Val Asp Tyr Pro 
1               5                   10                  15      


Tyr Arg Leu Trp 
            20  


<210>  157
<211>  26
<212>  PRT
<213>  Homo sapiens

<400>  157

Leu Pro Ala Leu Ser Thr Gly Leu Ile His Leu His Gln Asn Ile Val 
1               5                   10                  15      


Asp Val Gln Tyr Leu Tyr Gly Val Gly Ser 
            20                  25      


<210>  158
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  158

Gly Trp Arg Leu Leu Ala Pro Ile Thr Ala Tyr Ala Gln Gln Thr Arg 
1               5                   10                  15      


Gly Leu Leu Gly 
            20  


<210>  159
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  159

Thr Ser Leu Thr Gly Arg Asp Lys Asn 
1               5                   


<210>  160
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  160

Pro Cys Thr Cys Gly Ser Ser Asp Leu Tyr Leu Val Thr Arg His Ala 
1               5                   10                  15      


Asp Val Ile Pro 
            20  


<210>  161
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  161

Leu Lys Gly Ser Ser Gly Gly Pro 
1               5               


<210>  162
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  162

Gly Ile Phe Arg Ala Ala Val Cys Thr Arg Gly Val Ala Lys Ala 
1               5                   10                  15  


<210>  163
<211>  45
<212>  PRT
<213>  Homo sapiens

<400>  163

His Leu His Ala Pro Thr Gly Ser Gly Lys Ser Thr Lys Val Pro Ala 
1               5                   10                  15      


Ala Tyr Ala Ala Gln Gly Tyr Lys Val Leu Val Leu Asn Pro Ser Val 
            20                  25                  30          


Ala Ala Thr Leu Gly Phe Gly Ala Tyr Met Ser Lys Ala 
        35                  40                  45  


<210>  164
<211>  30
<212>  PRT
<213>  Homo sapiens

<400>  164

Ile Thr Tyr Ser Thr Tyr Gly Lys Phe Leu Ala Asp Gly Gly Cys Ser 
1               5                   10                  15      


Gly Gly Ala Tyr Asp Ile Ile Ile Cys Asp Glu Cys His Ser 
            20                  25                  30  


<210>  165
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  165

Ile Leu Gly Ile Gly Thr Val Leu Asp Gln Ala Glu Thr Ala Gly 
1               5                   10                  15  


<210>  166
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  166

Val Leu Ala Thr Ala Thr Pro Pro Gly 
1               5                   


<210>  167
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  167

Ser Val Ile Pro Thr Ser Gly Asp Val Val Val 
1               5                   10      


<210>  168
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  168

Ala Thr Asp Ala Leu Met Thr Gly Phe Thr Gly Asp Phe Asp Ser Val 
1               5                   10                  15      


Ile Asp Cys Asn 
            20  


<210>  169
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  169

Gln Thr Val Asp Phe Ser Leu Asp Pro Thr Phe 
1               5                   10      


<210>  170
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  170

Gln Arg Arg Gly Arg Thr Gly Arg Gly Arg 
1               5                   10  


<210>  171
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  171

Pro Gly Glu Arg Pro Ser Gly Met Phe Asp Ser 
1               5                   10      


<210>  172
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  172

Val Leu Cys Glu Cys Tyr Asp Ala Gly Cys Ala Trp Tyr Glu Leu 
1               5                   10                  15  


<210>  173
<211>  28
<212>  PRT
<213>  Homo sapiens

<400>  173

Pro Ala Glu Thr Thr Val Arg Leu Arg Ala Tyr Leu Asn Thr Pro Gly 
1               5                   10                  15      


Leu Pro Val Cys Gln Asp His Leu Glu Phe Trp Glu 
            20                  25              


<210>  174
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  174

Val Phe Thr Gly Leu Thr His Ile Asp Ala His Phe Leu Ser Gln Thr 
1               5                   10                  15      


Lys Gln 
        


<210>  175
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  175

Asn Phe Pro Tyr Leu Val Ala Tyr Gln Ala Thr Val Cys Ala Arg Ala 
1               5                   10                  15      


<210>  176
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  176

Cys Met Ser Ala Asp Leu Glu Val 
1               5               


<210>  177
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  177

Gly Gly Val Leu Ala Ala Leu Ala Ala Tyr Cys Leu Ser 
1               5                   10              


<210>  178
<211>  27
<212>  PRT
<213>  Homo sapiens

<400>  178

Phe Trp Ala Lys His Met Trp Asn Phe Ile Ser Gly Ile Gln Tyr Leu 
1               5                   10                  15      


Ala Gly Leu Ser Thr Leu Pro Gly Asn Pro Ala 
            20                  25          


<210>  179
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  179

Ala Ser Leu Met Ala Phe Thr Ala 
1               5               


<210>  180
<211>  30
<212>  PRT
<213>  Homo sapiens

<400>  180

Gly Ser Ile Gly Leu Gly Lys Val Leu Val Asp Ile Leu Ala Gly Tyr 
1               5                   10                  15      


Gly Ala Gly Val Ala Gly Ala Leu Val Ala Phe Lys Ile Met 
            20                  25                  30  


<210>  181
<211>  65
<212>  PRT
<213>  Homo sapiens

<400>  181

Val Asn Leu Leu Pro Ala Ile Leu Ser Pro Gly Ala Leu Val Val Gly 
1               5                   10                  15      


Val Val Cys Ala Ala Ile Leu Arg Arg His Val Gly Pro Gly Glu Gly 
            20                  25                  30          


Ala Val Gln Trp Met Asn Arg Leu Ile Ala Phe Ala Ser Arg Gly Asn 
        35                  40                  45              


His Val Ser Pro Thr His Tyr Val Pro Glu Ser Asp Ala Ala Ala Arg 
    50                  55                  60                  


Val 
65  


<210>  182
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  182

Arg Arg Leu Ala Arg Gly Ser Pro Pro Ser 
1               5                   10  


<210>  183
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  183

Ala Ser Ser Ser Ala Ser Gln Leu Ser Ala Pro Ser Leu Lys Ala Thr 
1               5                   10                  15      


Cys 
    


<210>  184
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  184

Ser Ser Met Pro Pro Leu Glu Gly Glu Pro Gly Asp Pro Asp Leu 
1               5                   10                  15  


<210>  185
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  185

Leu Ser Asn Ser Leu Leu Arg His His 
1               5                   


<210>  186
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  186

Pro Asp Leu Gly Val Arg Val Cys Glu Lys 
1               5                   10  


<210>  187
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  187

Pro Met Gly Phe Ser Tyr Asp Thr Arg Cys Phe Asp Ser Thr Val Thr 
1               5                   10                  15      


Glu 
    


<210>  188
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  188

Cys Gly Tyr Arg Arg Cys Arg Ala Ser Gly Val Leu 
1               5                   10          


<210>  189
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  189

Glu Ala Met Thr Arg Tyr Ser Ala Pro Pro Gly Asp 
1               5                   10          


<210>  190
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  190

Thr Pro Leu Ala Arg Ala Ala Trp Glu Thr Ala Arg His Thr Pro Val 
1               5                   10                  15      


Asn Ser Trp Leu Gly Asn Ile Ile Met 
            20                  25  


<210>  191
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  191

Arg Leu His Gly Leu Ser Ala Phe Ser Leu His Ser Tyr Ser 
1               5                   10                  


<210>  192
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  192

Pro Pro Leu Arg Ala Trp Arg His Arg 
1               5                   


<210>  193
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  193

Gly Gly Arg Ala Ala Ile Cys Gly Lys Tyr Leu Phe Asn Trp Ala Val 
1               5                   10                  15      


<210>  194
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  194

Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly 
1               5                   10                  15      


Ala Val Phe Val Ser Pro Ser Gln Glu Ile His Ala Arg Phe Arg Arg 
            20                  25                  30          


<210>  195
<211>  27
<212>  PRT
<213>  Homo sapiens

<400>  195

Ser Leu Leu Trp Gly Gly Val Thr Val Leu Ala Ala Met Leu Ile Ala 
1               5                   10                  15      


Gly Gln Val Ala Ser Ser Val Val Phe Leu Val 
            20                  25          


