                         SEQUENCE LISTING

<110>  Kymab Limited
       Atreca, Inc.
 
<120>  ANTI-MALARIAL ANTIBODIES THAT BIND CIRCUMSPOROZOITE PROTEIN

<130>  K00033-1 WO

<150>  62/311,059
<151>  2016-03-21

<160>  175   

<170>  PatentIn version 3.5

<210>  1
<211>  443
<212>  DNA
<213>  Homo sapiens

<400>  1
atggactgga cctggaggat cctctttttg gtggcagcag ccacaggtgc ccactcccag       60

gtccagcttg tgcagtctgg ggctgaggtg aagaagcctg gggcctcagt gaaggtttcc      120

tgcaaggctt ctggatacac cttcacaaac tatgctatgc attgggtgcg ccaggccccc      180

ggacaaaggc ttgagtggat gggatggatc aacgctggca atggtaatac aaaatattca      240

caaaatttcc agggcagagt caccattacc agggacacat ccgcgagcac agcctacatg      300

gagctgagca gcctgagatc tgaagacacg gctgtgtatt actgtgcgag agatgaatac      360

tatgcttcgg ggagttatta tgactactac tactacggta tggacgtctg gggccaaggg      420

accacggtca ccgtcacctc agc                                              443


<210>  2
<211>  128
<212>  PRT
<213>  Homo sapiens

<400>  2

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Ala Gly Asn Gly Asn Thr Lys Tyr Ser Gln Asn Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Glu Tyr Tyr Ala Ser Gly Ser Tyr Tyr Asp Tyr Tyr Tyr 
            100                 105                 110         


Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Thr Ser 
        115                 120                 125             


<210>  3
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  3

Gly Tyr Thr Phe Thr Asn Tyr Ala Met His 
1               5                   10  


<210>  4
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  4

Trp Ile Asn Ala Gly Asn Gly Asn Thr Lys Tyr Ser Gln Asn Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  5
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  5

Asp Glu Tyr Tyr Ala Ser Gly Ser Tyr Tyr Asp Tyr Tyr Tyr Tyr Gly 
1               5                   10                  15      


Met Asp Val 
            


<210>  6
<211>  389
<212>  DNA
<213>  Homo sapiens

<400>  6
atggcctggg ctctgctgct cctcaacctc ctcactcagg acacagggtc ctgggcccag       60

tctgccctga ctcagcctgc ctccgtgtct gggtctcctg gacagtcgat caccatctcc      120

tgcactggaa ccagcagtga tgttggtgtt tataactatg tctcctggtt ccaacagcac      180

ccaggcaaag cccccaaact catgatttat aatgtcagta agcggccctc aggggtttct      240

aatcgcttct ctggctccaa gtctggcaac acggcctccc tgacaatctc tgggctccag      300

gctgaggacg aggctgatta ttactgctgc tcatatgcag gtagtagcac ttgggtgttc      360

ggcggaggga ccaacctgac cgtcctagg                                        389


<210>  7
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  7

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Val Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Phe Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Asn Val Ser Lys Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Cys Ser Tyr Ala Gly Ser 
                85                  90                  95      


Ser Thr Trp Val Phe Gly Gly Gly Thr Asn Leu Thr Val Leu 
            100                 105                 110 


<210>  8
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  8

Thr Gly Thr Ser Ser Asp Val Gly Val Tyr Asn Tyr Val Ser 
1               5                   10                  


<210>  9
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  9

Asn Val Ser Lys Arg Pro Ser 
1               5           


<210>  10
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  10

Cys Ser Tyr Ala Gly Ser Ser Thr Trp Val 
1               5                   10  


<210>  11
<211>  443
<212>  DNA
<213>  Homo sapiens

<400>  11
atggactgga cctggagggt cctctttttg gtggcagcag ccacaggtgc ccactcccag       60

gtccagcttg tgcagtctgg ggctgaggtg aagaagcctg gggcctcagt gaaggtttcc      120

tgcagggctt ctggatacac cttcactaac tatgctatgc attgggtgcg ccaggccccc      180

ggacaaaggc ttgagtggat gggatggatc aacgctggca atggttacac aaaatattca      240

cagaagttcc aggacagagt caccattacc agggacacat ccgcgaccac agcctacatg      300

gagctgagca gcctgagatc tgaagacacg gctatgtatt actgtgcgag agattctttt      360

tacgatattt tgagtgggcc agtctatcac tactacggta tggacgtctg gggccaaggg      420

accacggtca ccgtctcctc agc                                              443


<210>  12
<211>  128
<212>  PRT
<213>  Homo sapiens

<400>  12

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Arg Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Ala Gly Asn Gly Tyr Thr Lys Tyr Ser Gln Lys Phe 
    50                  55                  60                  


Gln Asp Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Thr Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Ser Phe Tyr Asp Ile Leu Ser Gly Pro Val Tyr His Tyr 
            100                 105                 110         


Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125             


<210>  13
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  13

Gly Tyr Thr Phe Thr Asn Tyr Ala Met His 
1               5                   10  


<210>  14
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  14

Trp Ile Asn Ala Gly Asn Gly Tyr Thr Lys Tyr Ser Gln Lys Phe Gln 
1               5                   10                  15      


Asp 
    


<210>  15
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  15

Asp Ser Phe Tyr Asp Ile Leu Ser Gly Pro Val Tyr His Tyr Tyr Gly 
1               5                   10                  15      


Met Asp Val 
            


<210>  16
<211>  389
<212>  DNA
<213>  Homo sapiens

<400>  16
atggcctggg ctctgctgct cctcaacctc ctcactcagg ccacagggtc ctgggcccag       60

tctgccctga ctcagcctga ctccgtgtct gggtctcctg gacagtcgat caccatctcc      120

tgcactggaa ccagcaatga tgttggtatt tataaccatg tctcctggta ccaacagcac      180

ccaggcaaag cccccaaact catgatttat gatgtcaata agcggccctc agggatttct      240

aatcgcttct ctggctccaa gtctggcgac acggcctccc tgacaatctc tgggctccag      300

gctgaggacg aggctgatta ttactgctgc tcatatgcag gtagtagcgc ttgggtgttc      360

ggcggaggga ccaaattgac cgtccttgg                                        389


<210>  17
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  17

Gln Ser Ala Leu Thr Gln Pro Asp Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Asn Asp Val Gly Ile Tyr 
            20                  25                  30          


Asn His Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Asp Val Asn Lys Arg Pro Ser Gly Ile Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asp Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Cys Ser Tyr Ala Gly Ser 
                85                  90                  95      


Ser Ala Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  18
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  18

Thr Gly Thr Ser Asn Asp Val Gly Ile Tyr Asn His Val Ser 
1               5                   10                  


<210>  19
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  19

Asp Val Asn Lys Arg Pro Ser 
1               5           


<210>  20
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  20

Cys Ser Tyr Ala Gly Ser Ser Ala Trp Val 
1               5                   10  


<210>  21
<211>  437
<212>  DNA
<213>  Homo sapiens

<400>  21
atggactgga cctggaggat cctctttttg gtggcagcag ccgcaggtgc ccactcccag       60

gtccagcttg tgcagtctgg ggctgaggtg aagaagcctg gggcctcagt gaaggtttcc      120

tgcaaggctt ctggattcac cttcactgac tatgctatgc attgggtgcg ccaggccccc      180

ggacaaaggc ttgagtggat gggctggatc aacgctggca atggttacac aaaatattca      240

cagaagttcc aggacagact caccattacc agggacacat tcgcgagcac agtctacatg      300

gagctgagca gcctgagatc tgaagacacg actgtgtatt actgtgcgag agatgggttt      360

tgtcctagta acacttgttc tggttactac ggtatggacg tctggggcca agggaccacg      420

gtcaccgtct cctcagc                                                     437


<210>  22
<211>  126
<212>  PRT
<213>  Homo sapiens

<400>  22

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Ala Gly Asn Gly Tyr Thr Lys Tyr Ser Gln Lys Phe 
    50                  55                  60                  


Gln Asp Arg Leu Thr Ile Thr Arg Asp Thr Phe Ala Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Thr Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Phe Cys Pro Ser Asn Thr Cys Ser Gly Tyr Tyr Gly 
            100                 105                 110         


Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125     


<210>  23
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  23

Gly Phe Thr Phe Thr Asp Tyr Ala Met His 
1               5                   10  


<210>  24
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  24

Trp Ile Asn Ala Gly Asn Gly Tyr Thr Lys Tyr Ser Gln Lys Phe Gln 
1               5                   10                  15      


Asp 
    


<210>  25
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  25

Asp Gly Phe Cys Pro Ser Asn Thr Cys Ser Gly Tyr Tyr Gly Met Asp 
1               5                   10                  15      


Val 
    


<210>  26
<211>  389
<212>  DNA
<213>  Homo sapiens

<400>  26
atggcctggg ctctgctgct cctcaacctc ctcactcagg acacagggtc ctgggcccag       60

tctgccctga ctcagcctgc ctccgtgtct gggtctcctg gacagtcgat caccatctcc      120

tgcactggaa ccagcagtga tgttggttct tataactatg tctcctggta ccaacagcac      180

ccaggcaaag cccccaaact catgatttat gatgtcaata cgcggccctc aggggtttct      240

attcgcttct ctgcctccaa gtctggcaac acggcctccc tgacagtctc tgggctccag      300

gctgaggacg aggctgttta ttactgctcc tcatatgcag gtagtagcac ttgggtgttc      360

ggcggaggga ccaagctgac cgtcctagg                                        389


<210>  27
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  27

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Ser Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Asp Val Asn Thr Arg Pro Ser Gly Val Ser Ile Arg Phe 
    50                  55                  60                  


Ser Ala Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Val Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Val Tyr Tyr Cys Ser Ser Tyr Ala Gly Ser 
                85                  90                  95      


Ser Thr Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  28
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  28

Thr Gly Thr Ser Ser Asp Val Gly Ser Tyr Asn Tyr Val Ser 
1               5                   10                  


<210>  29
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  29

Asp Val Asn Thr Arg Pro Ser 
1               5           


<210>  30
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  30

Ser Ser Tyr Ala Gly Ser Ser Thr Trp Val 
1               5                   10  


<210>  31
<211>  437
<212>  DNA
<213>  Homo sapiens

<400>  31
atggactgga cctggaggat cctctttttg gtggcagcag ccacaggtgc ccactcccag       60

gtccagcttg tgcagtctgg ggctgaggtg aagaagcctg gggcctcagt gagggtttcc      120

tgcaaggctt ctggattcac cttcactagt tatgctatgc attgggtgcg ccaggccccc      180

ggacaaaggc ttgagtggat gggatggatc aacgctggca atggtcacac aaaatattca      240

cagaagttcc aggacagagt cgccattacc agggacacat ccgcgaccac agtctacatg      300

gacctgagca gcctgagatc tgaagacacg gctgtgtatt actgtacgag agatggattt      360

tgtactagta ccacctgctc cgaccactac ggtatggacg tctggggcca agggaccacg      420

gtcaccgtct cctcagc                                                     437


<210>  32
<211>  126
<212>  PRT
<213>  Homo sapiens

<400>  32

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Arg Val Ser Cys Lys Ala Ser Gly Phe Thr Phe Thr Ser Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Ala Gly Asn Gly His Thr Lys Tyr Ser Gln Lys Phe 
    50                  55                  60                  


Gln Asp Arg Val Ala Ile Thr Arg Asp Thr Ser Ala Thr Thr Val Tyr 
65                  70                  75                  80  


Met Asp Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Asp Gly Phe Cys Thr Ser Thr Thr Cys Ser Asp His Tyr Gly 
            100                 105                 110         


Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125     


<210>  33
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  33

Gly Phe Thr Phe Thr Ser Tyr Ala Met His 
1               5                   10  


<210>  34
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  34

Trp Ile Asn Ala Gly Asn Gly His Thr Lys Tyr Ser Gln Lys Phe Gln 
1               5                   10                  15      


Asp 
    


<210>  35
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  35

Asp Gly Phe Cys Thr Ser Thr Thr Cys Ser Asp His Tyr Gly Met Asp 
1               5                   10                  15      


Val 
    


<210>  36
<211>  389
<212>  DNA
<213>  Homo sapiens

<400>  36
atggcctggg ctctgctgct cctcaacctc ctcactcagg acacagggtc ctgggcccag       60

tctgccctga ctcagcctgc ctccgtgtct gggtctcctg gacagtcgat caccatctcc      120

tgcactggaa ccagcagtga tgttggtagt tataactatg tctcctggta ccaacagcac      180

ccaggcaaag cccccaaatt catgatttat gatgtcagta agcggccctc aggggtttct      240

aatcgcttct ctggctccaa gtctggcaac acggcctccc tgacaatctc tgggctccag      300

gctgaggacg aggctgatta ttactgctgc tcatatgcag gtagtagcac ttgggtgttc      360

ggcggaggga ccaagctgac cgtccttgg                                        389


<210>  37
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  37

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Ser Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Phe 
        35                  40                  45              


Met Ile Tyr Asp Val Ser Lys Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Cys Ser Tyr Ala Gly Ser 
                85                  90                  95      


Ser Thr Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  38
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  38

Thr Gly Thr Ser Ser Asp Val Gly Ser Tyr Asn Tyr Val Ser 
1               5                   10                  


<210>  39
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  39

Asp Val Ser Lys Arg Pro Ser 
1               5           


<210>  40
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  40

Cys Ser Tyr Ala Gly Ser Ser Thr Trp Val 
1               5                   10  


<210>  41
<211>  1260
<212>  DNA
<213>  Synthetic

<400>  41
cgaattgggg atcgatccac tagttaatta acgcgatgta aggtaccata tgctgtttca       60

agaatatcag tgctatggca gcagcagcaa cacccgtgtg ctgaacgagc tgaactatga      120

taacgcgggc accaacctgt ataacgagct ggaaatgaac tattacggca agcaggaaaa      180

ctggtacagc ctgaaaaaaa acagccgtag cctgggcgaa aacgatgatg gcaacaacaa      240

caacggcgat aacggccgtg aaggcaaaga tgaagataaa cgcgacggca ataacgaaga      300

taacgagaaa ctgcgtaaac cgaaacacaa aaaactgaaa cagccgggcg atggcaatcc      360

ggaccctaat gcgaatccaa atgtcgaccc taatgccaat ccgaatgtag atccgaacgc      420

gaatccgaac gtggatccaa atgcaaatcc caatgccaat ccaaatgcaa acccaaacgc      480

gaatcccaat gccaatccca acgcaaatcc aaatgcgaac ccaaatgcaa atcccaacgc      540

aaatcccaat gcgaacccca atgccaatcc caacgcaaat ccaaatgcca accctaatgc      600

aaatccaaat gctaatccaa atgtagatcc taacgctaac ccaaatgcta accctaacgc      660

aaaccctaat gccaatccta atgccaatcc aaacgccaat ccgaacgcga acccaaatgc      720

caaccctaac gcgaatccta atgccaatcc caatgccaat ccaaatgcca atccgaacgc      780

gaatccgaat gcgaatccga atgctaaccc taatgccaac cccaatgcca accccaatgc      840

taatcccaac gcaaacccta acaaaaacaa ccagggcaac ggccagggcc ataacatgcc      900

gaacgatccg aaccgtaacg tggatgaaaa cgcgaacgcg aacaacgcgg tgaaaaacaa      960

caacaacgaa gaaccgagcg ataaacacat cgaaaaatac ctgaaaaaga tccagaacag     1020

cctgagcacc gaatggtctc cgtgcagcgt gacctgcggc aacggcattc aggtgcgtat     1080

taaaccgggc agcgcgaaca aaccgaaaga tgagctggat tacgaaaacg acatcgaaaa     1140

aaaaatctgc aaaatggaaa aatgcagcag cgtgtttaac gtggtgaaca gcagcattgg     1200

cctgattctg gaacatcatc atcatcatca ctaaccgctc gagcggagct cttacatcgc     1260


<210>  42
<211>  394
<212>  PRT
<213>  Synthetic

<400>  42

Met Leu Phe Gln Glu Tyr Gln Cys Tyr Gly Ser Ser Ser Asn Thr Arg 
1               5                   10                  15      


Val Leu Asn Glu Leu Asn Tyr Asp Asn Ala Gly Thr Asn Leu Tyr Asn 
            20                  25                  30          


Glu Leu Glu Met Asn Tyr Tyr Gly Lys Gln Glu Asn Trp Tyr Ser Leu 
        35                  40                  45              


Lys Lys Asn Ser Arg Ser Leu Gly Glu Asn Asp Asp Gly Asn Asn Asn 
    50                  55                  60                  


Asn Gly Asp Asn Gly Arg Glu Gly Lys Asp Glu Asp Lys Arg Asp Gly 
65                  70                  75                  80  


Asn Asn Glu Asp Asn Glu Lys Leu Arg Lys Pro Lys His Lys Lys Leu 
                85                  90                  95      


Lys Gln Pro Gly Asp Gly Asn Pro Asp Pro Asn Ala Asn Pro Asn Val 
            100                 105                 110         


Asp Pro Asn Ala Asn Pro Asn Val Asp Pro Asn Ala Asn Pro Asn Val 
        115                 120                 125             


Asp Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala 
    130                 135                 140                 


Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala 
145                 150                 155                 160 


Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala 
                165                 170                 175     


Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Val 
            180                 185                 190         


Asp Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala 
        195                 200                 205             


Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala 
    210                 215                 220                 


Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala 
225                 230                 235                 240 


Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala 
                245                 250                 255     


Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Lys 
            260                 265                 270         


Asn Asn Gln Gly Asn Gly Gln Gly His Asn Met Pro Asn Asp Pro Asn 
        275                 280                 285             


Arg Asn Val Asp Glu Asn Ala Asn Ala Asn Asn Ala Val Lys Asn Asn 
    290                 295                 300                 


Asn Asn Glu Glu Pro Ser Asp Lys His Ile Glu Lys Tyr Leu Lys Lys 
305                 310                 315                 320 


Ile Gln Asn Ser Leu Ser Thr Glu Trp Ser Pro Cys Ser Val Thr Cys 
                325                 330                 335     


Gly Asn Gly Ile Gln Val Arg Ile Lys Pro Gly Ser Ala Asn Lys Pro 
            340                 345                 350         


Lys Asp Glu Leu Asp Tyr Glu Asn Asp Ile Glu Lys Lys Ile Cys Lys 
        355                 360                 365             


Met Glu Lys Cys Ser Ser Val Phe Asn Val Val Asn Ser Ser Ile Gly 
    370                 375                 380                 


Leu Ile Leu Glu His His His His His His 
385                 390                 


<210>  43
<211>  388
<212>  PRT
<213>  Plasmodium falciparum

<400>  43

Met Leu Phe Gln Glu Tyr Gln Cys Tyr Gly Ser Ser Ser Asn Thr Arg 
1               5                   10                  15      


Val Leu Asn Glu Leu Asn Tyr Asp Asn Ala Gly Thr Asn Leu Tyr Asn 
            20                  25                  30          


Glu Leu Glu Met Asn Tyr Tyr Gly Lys Gln Glu Asn Trp Tyr Ser Leu 
        35                  40                  45              


Lys Lys Asn Ser Arg Ser Leu Gly Glu Asn Asp Asp Gly Asn Asn Asn 
    50                  55                  60                  


Asn Gly Asp Asn Gly Arg Glu Gly Lys Asp Glu Asp Lys Arg Asp Gly 
65                  70                  75                  80  


Asn Asn Glu Asp Asn Glu Lys Leu Arg Lys Pro Lys His Lys Lys Leu 
                85                  90                  95      


Lys Gln Pro Gly Asp Gly Asn Pro Asp Pro Asn Ala Asn Pro Asn Val 
            100                 105                 110         


Asp Pro Asn Ala Asn Pro Asn Val Asp Pro Asn Ala Asn Pro Asn Val 
        115                 120                 125             


Asp Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala 
    130                 135                 140                 


Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala 
145                 150                 155                 160 


Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala 
                165                 170                 175     


Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Val 
            180                 185                 190         


Asp Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala 
        195                 200                 205             


Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala 
    210                 215                 220                 


Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala 
225                 230                 235                 240 


Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala 
                245                 250                 255     


Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Lys 
            260                 265                 270         


Asn Asn Gln Gly Asn Gly Gln Gly His Asn Met Pro Asn Asp Pro Asn 
        275                 280                 285             


Arg Asn Val Asp Glu Asn Ala Asn Ala Asn Asn Ala Val Lys Asn Asn 
    290                 295                 300                 


Asn Asn Glu Glu Pro Ser Asp Lys His Ile Glu Lys Tyr Leu Lys Lys 
305                 310                 315                 320 


Ile Gln Asn Ser Leu Ser Thr Glu Trp Ser Pro Cys Ser Val Thr Cys 
                325                 330                 335     


Gly Asn Gly Ile Gln Val Arg Ile Lys Pro Gly Ser Ala Asn Lys Pro 
            340                 345                 350         


Lys Asp Glu Leu Asp Tyr Glu Asn Asp Ile Glu Lys Lys Ile Cys Lys 
        355                 360                 365             


Met Glu Lys Cys Ser Ser Val Phe Asn Val Val Asn Ser Ser Ile Gly 
    370                 375                 380                 


Leu Ile Leu Glu 
385             


<210>  44
<211>  160
<212>  PRT
<213>  Synthetic

<400>  44

Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro 
1               5                   10                  15      


Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro 
            20                  25                  30          


Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro 
        35                  40                  45              


Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro 
    50                  55                  60                  


Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro 
65                  70                  75                  80  


Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro 
                85                  90                  95      


Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro 
            100                 105                 110         


Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro 
        115                 120                 125             


Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro 
    130                 135                 140                 


Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro 
145                 150                 155                 160 


<210>  45
<211>  40
<212>  PRT
<213>  Synthetic

<400>  45

Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro 
1               5                   10                  15      


Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro 
            20                  25                  30          


Asn Ala Asn Pro Asn Ala Asn Pro 
        35                  40  


<210>  46
<211>  16
<212>  PRT
<213>  Synthetic

<400>  46

Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro 
1               5                   10                  15      


<210>  47
<211>  4
<212>  PRT
<213>  Synthetic

<400>  47

Asn Ala Asn Pro 
1               


<210>  48
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  48

Gly Cys Cys Ala Gly Thr Cys Thr Ala Thr Cys 
1               5                   10      


<210>  49
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  49

Thr Gly Gly Gly Thr Thr Thr Thr Gly Thr Cys Cys Thr 
1               5                   10              


<210>  50
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  50

Ala Cys Thr Thr Gly Thr Thr Cys Thr Gly Gly Thr 
1               5                   10          


<210>  51
<211>  24
<212>  PRT
<213>  Synthetic

<400>  51

Met Asp Pro Lys Gly Ser Leu Ser Trp Arg Ile Leu Leu Phe Leu Ser 
1               5                   10                  15      


Leu Ala Phe Glu Leu Ser Tyr Gly 
            20                  


<210>  52
<211>  20
<212>  PRT
<213>  Synthetic

<400>  52

Met Ser Val Pro Thr Gln Val Leu Gly Leu Leu Leu Leu Trp Leu Thr 
1               5                   10                  15      


Asp Ala Arg Cys 
            20  


<210>  53
<211>  20
<212>  PRT
<213>  Synthetic

<400>  53

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly 
            20  


<210>  54
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  54

Asn Tyr Ala Met His 
1               5   


<210>  55
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  55

Gly Tyr Thr Phe Thr Asn Tyr 
1               5           


<210>  56
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  56

Asn Ala Gly Asn Gly Asn 
1               5       


<210>  57
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  57

Asp Tyr Ala Met His 
1               5   


<210>  58
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  58

Gly Tyr Thr Phe Thr Ser Tyr 
1               5           


<210>  59
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  59

Ser Tyr Ala Met His 
1               5   


<210>  60
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  60

Gly Tyr Thr Phe Thr Ser Tyr Ala Met His 
1               5                   10  


<210>  61
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  61

Trp Ile Asn Ala Gly Asn Gly Asn Thr Lys Tyr Ser Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  62
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  62

Asp Asn Tyr Tyr Asp Ser Gly Ser Tyr Tyr Asp Tyr Tyr Tyr Tyr Gly 
1               5                   10                  15      


Met Asp Val 
            


<210>  63
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  63

Thr Gly Thr Ser Ser Asp Val Gly Ser Tyr Asn His Val Ser 
1               5                   10                  


<210>  64
<211>  443
<212>  PRT
<213>  Homo sapiens

<400>  64

Ala Thr Gly Gly Ala Cys Thr Gly Gly Ala Cys Cys Thr Gly Gly Ala 
1               5                   10                  15      


Gly Gly Ala Thr Cys Cys Thr Cys Thr Thr Thr Thr Thr Gly Gly Thr 
            20                  25                  30          


Gly Gly Cys Ala Gly Cys Ala Gly Cys Cys Ala Cys Ala Gly Gly Thr 
        35                  40                  45              


Gly Cys Cys Cys Ala Cys Thr Cys Cys Cys Ala Gly Gly Thr Cys Cys 
    50                  55                  60                  


Ala Gly Cys Thr Thr Gly Thr Gly Cys Ala Gly Thr Cys Thr Gly Gly 
65                  70                  75                  80  


Gly Gly Cys Thr Gly Ala Gly Gly Thr Gly Ala Ala Gly Ala Ala Gly 
                85                  90                  95      


Cys Cys Thr Gly Gly Gly Gly Cys Cys Thr Cys Ala Gly Thr Gly Ala 
            100                 105                 110         


Ala Gly Gly Thr Thr Thr Cys Cys Thr Gly Cys Ala Ala Gly Gly Cys 
        115                 120                 125             


Thr Thr Cys Thr Gly Gly Ala Thr Ala Cys Ala Cys Cys Thr Thr Cys 
    130                 135                 140                 


Ala Cys Thr Ala Gly Thr Thr Ala Thr Gly Cys Thr Ala Thr Gly Cys 
145                 150                 155                 160 


Ala Thr Thr Gly Gly Gly Thr Gly Cys Gly Cys Cys Ala Gly Gly Cys 
                165                 170                 175     


Cys Cys Cys Cys Gly Gly Ala Cys Ala Ala Ala Gly Gly Cys Thr Thr 
            180                 185                 190         


Gly Ala Gly Thr Gly Gly Ala Thr Gly Gly Gly Ala Thr Gly Gly Ala 
        195                 200                 205             


Thr Cys Ala Ala Cys Gly Cys Thr Gly Gly Cys Ala Ala Thr Gly Gly 
    210                 215                 220                 


Thr Ala Ala Cys Ala Cys Ala Ala Ala Ala Thr Ala Thr Thr Cys Ala 
225                 230                 235                 240 


Cys Ala Gly Ala Ala Gly Thr Thr Cys Cys Ala Gly Gly Gly Cys Gly 
                245                 250                 255     


Gly Ala Gly Thr Cys Ala Cys Cys Ala Thr Thr Ala Cys Cys Ala Gly 
            260                 265                 270         


Gly Gly Ala Cys Ala Cys Ala Thr Cys Cys Gly Cys Gly Ala Gly Cys 
        275                 280                 285             


Ala Cys Ala Gly Cys Cys Thr Ala Cys Ala Thr Gly Gly Ala Gly Cys 
    290                 295                 300                 


Thr Gly Ala Gly Cys Ala Gly Cys Cys Thr Gly Ala Gly Ala Thr Cys 
305                 310                 315                 320 


Thr Gly Ala Ala Gly Ala Cys Ala Cys Gly Gly Cys Thr Gly Thr Ala 
                325                 330                 335     


Thr Ala Thr Thr Ala Cys Thr Gly Thr Gly Cys Gly Ala Gly Ala Gly 
            340                 345                 350         


Ala Cys Ala Ala Thr Thr Ala Cys Thr Ala Thr Gly Ala Thr Thr Cys 
        355                 360                 365             


Gly Gly Gly Gly Ala Gly Thr Thr Ala Thr Thr Ala Thr Gly Ala Cys 
    370                 375                 380                 


Thr Ala Cys Thr Ala Cys Thr Ala Cys Thr Ala Cys Gly Gly Thr Ala 
385                 390                 395                 400 


Thr Gly Gly Ala Cys Gly Thr Cys Thr Gly Gly Gly Gly Cys Cys Ala 
                405                 410                 415     


Ala Gly Gly Gly Ala Cys Cys Ala Cys Gly Gly Thr Cys Ala Cys Cys 
            420                 425                 430         


Gly Thr Cys Thr Cys Cys Thr Cys Ala Gly Cys 
        435                 440             


<210>  65
<211>  128
<212>  PRT
<213>  Homo sapiens

<400>  65

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Ala Gly Asn Gly Asn Thr Lys Tyr Ser Gln Lys Phe 
    50                  55                  60                  


Gln Gly Gly Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Asn Tyr Tyr Asp Ser Gly Ser Tyr Tyr Asp Tyr Tyr Tyr 
            100                 105                 110         


Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125             


<210>  66
<211>  389
<212>  PRT
<213>  Homo sapiens

<400>  66

Ala Thr Gly Gly Cys Cys Thr Gly Gly Gly Cys Thr Cys Thr Gly Cys 
1               5                   10                  15      


Thr Gly Cys Thr Cys Cys Thr Cys Ala Ala Cys Cys Thr Cys Cys Thr 
            20                  25                  30          


Cys Ala Cys Thr Cys Ala Gly Gly Ala Cys Ala Cys Ala Gly Gly Gly 
        35                  40                  45              


Thr Cys Cys Thr Gly Gly Gly Cys Cys Cys Ala Gly Thr Cys Thr Gly 
    50                  55                  60                  


Cys Cys Cys Thr Gly Ala Cys Thr Cys Ala Gly Cys Cys Thr Gly Cys 
65                  70                  75                  80  


Cys Thr Cys Cys Gly Thr Gly Thr Cys Thr Gly Gly Gly Thr Cys Thr 
                85                  90                  95      


Cys Cys Thr Gly Gly Ala Cys Ala Gly Thr Cys Gly Ala Thr Cys Ala 
            100                 105                 110         


Cys Cys Thr Thr Cys Thr Cys Cys Thr Gly Cys Ala Cys Thr Gly Gly 
        115                 120                 125             


Ala Ala Cys Cys Ala Gly Cys Ala Gly Thr Gly Ala Thr Gly Thr Thr 
    130                 135                 140                 


Gly Gly Thr Ala Gly Thr Thr Ala Thr Ala Ala Thr Cys Ala Thr Gly 
145                 150                 155                 160 


Thr Cys Thr Cys Cys Thr Gly Gly Thr Ala Cys Cys Ala Ala Cys Ala 
                165                 170                 175     


Gly Cys Ala Cys Cys Cys Ala Gly Gly Cys Ala Ala Ala Gly Cys Cys 
            180                 185                 190         


Cys Cys Cys Ala Ala Ala Cys Thr Cys Ala Thr Gly Ala Thr Thr Thr 
        195                 200                 205             


Ala Thr Gly Ala Thr Gly Thr Cys Ala Gly Thr Ala Ala Gly Cys Gly 
    210                 215                 220                 


Gly Cys Cys Cys Thr Cys Ala Gly Gly Gly Gly Thr Thr Thr Cys Thr 
225                 230                 235                 240 


Ala Ala Thr Cys Gly Cys Thr Thr Cys Thr Cys Thr Gly Gly Cys Thr 
                245                 250                 255     


Cys Cys Ala Ala Gly Thr Cys Thr Gly Gly Cys Ala Ala Cys Ala Cys 
            260                 265                 270         


Gly Gly Cys Cys Thr Cys Cys Cys Thr Gly Ala Cys Ala Ala Thr Cys 
        275                 280                 285             


Thr Cys Thr Gly Gly Gly Cys Thr Cys Cys Ala Gly Gly Cys Thr Gly 
    290                 295                 300                 


Ala Gly Gly Ala Cys Gly Ala Gly Gly Cys Thr Gly Ala Thr Thr Ala 
305                 310                 315                 320 


Thr Thr Ala Cys Thr Gly Cys Thr Gly Cys Thr Cys Ala Thr Ala Thr 
                325                 330                 335     


Gly Cys Ala Gly Gly Thr Ala Gly Thr Ala Gly Cys Ala Cys Thr Thr 
            340                 345                 350         


Gly Gly Gly Thr Gly Thr Thr Cys Gly Gly Cys Gly Gly Ala Gly Gly 
        355                 360                 365             


Gly Ala Cys Cys Ala Ala Gly Cys Thr Gly Ala Cys Cys Gly Thr Cys 
    370                 375                 380                 


Cys Thr Ala Gly Gly 
385                 


<210>  67
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  67

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Phe Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Ser Tyr 
            20                  25                  30          


Asn His Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Asp Val Ser Lys Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Cys Ser Tyr Ala Gly Ser 
                85                  90                  95      


Ser Thr Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  68
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  68

Trp Ile Asn Ala Gly Asn Gly Tyr Thr Lys Tyr Ser Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  69
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  69

Asp Asn Tyr Tyr Asp Ser Gly Ser Tyr Tyr Glu Tyr Cys Tyr Tyr Gly 
1               5                   10                  15      


Met Asp Val 
            


<210>  70
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  70

Cys Ser Tyr Val Gly Ser Ser Thr Trp Val 
1               5                   10  


<210>  71
<211>  443
<212>  PRT
<213>  Homo sapiens

<400>  71

Ala Thr Gly Gly Ala Cys Thr Gly Gly Ala Cys Cys Thr Gly Gly Ala 
1               5                   10                  15      


Gly Gly Ala Thr Cys Cys Thr Cys Thr Thr Thr Thr Thr Gly Gly Thr 
            20                  25                  30          


Gly Gly Cys Ala Gly Cys Ala Gly Cys Cys Ala Cys Ala Gly Gly Thr 
        35                  40                  45              


Gly Cys Cys Cys Ala Cys Thr Cys Cys Cys Ala Gly Gly Thr Cys Cys 
    50                  55                  60                  


Ala Gly Cys Thr Thr Gly Thr Gly Cys Ala Gly Thr Cys Thr Gly Gly 
65                  70                  75                  80  


Gly Gly Cys Thr Gly Ala Gly Gly Thr Gly Ala Ala Gly Ala Ala Gly 
                85                  90                  95      


Cys Cys Thr Gly Gly Gly Gly Cys Cys Thr Cys Ala Gly Thr Gly Ala 
            100                 105                 110         


Ala Gly Gly Thr Thr Thr Cys Cys Thr Gly Cys Ala Ala Gly Gly Cys 
        115                 120                 125             


Gly Thr Cys Thr Gly Gly Ala Thr Ala Cys Ala Cys Cys Thr Thr Cys 
    130                 135                 140                 


Ala Cys Gly Ala Ala Cys Thr Ala Thr Gly Cys Thr Ala Thr Gly Cys 
145                 150                 155                 160 


Ala Thr Thr Gly Gly Gly Thr Gly Cys Gly Cys Cys Ala Gly Gly Cys 
                165                 170                 175     


Cys Cys Cys Cys Gly Gly Ala Cys Ala Ala Ala Gly Gly Cys Thr Thr 
            180                 185                 190         


Gly Ala Gly Thr Gly Gly Ala Thr Gly Gly Gly Ala Thr Gly Gly Ala 
        195                 200                 205             


Thr Cys Ala Ala Cys Gly Cys Thr Gly Gly Cys Ala Ala Thr Gly Gly 
    210                 215                 220                 


Thr Thr Ala Cys Ala Cys Ala Ala Ala Ala Thr Ala Thr Thr Cys Ala 
225                 230                 235                 240 


Cys Ala Gly Ala Ala Gly Thr Thr Cys Cys Ala Gly Gly Gly Cys Ala 
                245                 250                 255     


Gly Ala Gly Thr Cys Ala Cys Cys Ala Thr Thr Ala Thr Cys Ala Gly 
            260                 265                 270         


Gly Gly Ala Cys Ala Cys Ala Thr Cys Thr Gly Cys Gly Ala Cys Cys 
        275                 280                 285             


Ala Cys Ala Gly Cys Cys Thr Ala Thr Ala Thr Gly Gly Ala Gly Cys 
    290                 295                 300                 


Thr Gly Ala Gly Cys Ala Gly Cys Cys Thr Gly Ala Gly Ala Thr Cys 
305                 310                 315                 320 


Thr Gly Ala Ala Gly Ala Cys Ala Cys Gly Gly Cys Thr Gly Thr Gly 
                325                 330                 335     


Thr Ala Thr Thr Ala Cys Thr Gly Thr Gly Cys Gly Ala Gly Ala Gly 
            340                 345                 350         


Ala Thr Ala Ala Thr Thr Ala Thr Thr Ala Thr Gly Ala Thr Thr Cys 
        355                 360                 365             


Gly Gly Gly Gly Ala Gly Thr Thr Ala Thr Thr Ala Thr Gly Ala Ala 
    370                 375                 380                 


Thr Ala Cys Thr Gly Cys Thr Ala Cys Thr Ala Cys Gly Gly Thr Ala 
385                 390                 395                 400 


Thr Gly Gly Ala Cys Gly Thr Cys Thr Gly Gly Gly Gly Cys Cys Ala 
                405                 410                 415     


Ala Gly Gly Gly Ala Cys Cys Ala Cys Gly Gly Thr Cys Ala Cys Cys 
            420                 425                 430         


Gly Thr Cys Thr Cys Cys Thr Cys Ala Gly Cys 
        435                 440             


<210>  72
<211>  128
<212>  PRT
<213>  Homo sapiens

<400>  72

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Ala Gly Asn Gly Tyr Thr Lys Tyr Ser Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Ile Arg Asp Thr Ser Ala Thr Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Asn Tyr Tyr Asp Ser Gly Ser Tyr Tyr Glu Tyr Cys Tyr 
            100                 105                 110         


Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125             


<210>  73
<211>  389
<212>  PRT
<213>  Homo sapiens

<400>  73

Ala Thr Gly Gly Cys Cys Thr Gly Gly Gly Cys Thr Cys Thr Gly Cys 
1               5                   10                  15      


Thr Gly Cys Thr Cys Cys Thr Cys Ala Ala Cys Cys Thr Cys Cys Thr 
            20                  25                  30          


Cys Ala Cys Thr Cys Ala Gly Gly Ala Cys Ala Cys Ala Gly Gly Gly 
        35                  40                  45              


Thr Cys Cys Thr Gly Gly Gly Cys Cys Cys Ala Gly Thr Cys Thr Gly 
    50                  55                  60                  


Cys Cys Cys Thr Gly Ala Cys Thr Cys Ala Gly Cys Cys Thr Gly Cys 
65                  70                  75                  80  


Cys Thr Cys Cys Gly Thr Gly Thr Cys Thr Gly Gly Gly Thr Cys Thr 
                85                  90                  95      


Cys Cys Thr Gly Gly Ala Cys Ala Gly Thr Cys Gly Ala Thr Cys Ala 
            100                 105                 110         


Cys Cys Ala Thr Cys Thr Cys Cys Thr Gly Cys Ala Cys Thr Gly Gly 
        115                 120                 125             


Ala Ala Cys Cys Ala Gly Cys Ala Gly Thr Gly Ala Thr Gly Thr Thr 
    130                 135                 140                 


Gly Gly Thr Ala Gly Thr Thr Ala Thr Ala Ala Cys Cys Ala Thr Gly 
145                 150                 155                 160 


Thr Cys Thr Cys Cys Thr Gly Gly Thr Ala Cys Cys Ala Ala Cys Ala 
                165                 170                 175     


Ala Thr Ala Cys Cys Cys Ala Gly Gly Cys Ala Ala Ala Gly Cys Cys 
            180                 185                 190         


Cys Cys Cys Ala Ala Ala Cys Thr Cys Cys Thr Gly Ala Thr Thr Thr 
        195                 200                 205             


Ala Thr Gly Ala Thr Gly Thr Cys Ala Gly Thr Ala Ala Gly Cys Gly 
    210                 215                 220                 


Gly Cys Cys Cys Thr Cys Ala Gly Gly Gly Gly Thr Thr Thr Cys Thr 
225                 230                 235                 240 


Ala Ala Thr Cys Gly Cys Thr Thr Cys Thr Cys Thr Gly Gly Cys Thr 
                245                 250                 255     


Cys Cys Ala Ala Gly Thr Cys Thr Gly Gly Cys Ala Ala Cys Ala Cys 
            260                 265                 270         


Gly Gly Cys Cys Thr Cys Cys Cys Thr Gly Ala Cys Ala Ala Thr Cys 
        275                 280                 285             


Thr Ala Thr Gly Gly Gly Cys Thr Cys Cys Ala Gly Gly Cys Thr Gly 
    290                 295                 300                 


Ala Gly Gly Ala Cys Gly Ala Gly Gly Cys Thr Gly Ala Thr Thr Ala 
305                 310                 315                 320 


Thr Thr Ala Cys Thr Gly Cys Thr Gly Cys Thr Cys Ala Thr Ala Thr 
                325                 330                 335     


Gly Thr Ala Gly Gly Thr Ala Gly Cys Ala Gly Cys Ala Cys Thr Thr 
            340                 345                 350         


Gly Gly Gly Thr Gly Thr Thr Cys Gly Gly Cys Gly Gly Ala Gly Gly 
        355                 360                 365             


Gly Ala Cys Cys Ala Ala Gly Cys Thr Gly Ala Cys Cys Gly Thr Cys 
    370                 375                 380                 


Cys Thr Ala Gly Gly 
385                 


<210>  74
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  74

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Ser Tyr 
            20                  25                  30          


Asn His Val Ser Trp Tyr Gln Gln Tyr Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Asp Val Ser Lys Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Tyr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Cys Ser Tyr Val Gly Ser 
                85                  90                  95      


Ser Thr Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  75
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  75

Gly Tyr Thr Phe Ser Asn Tyr Ala Met His 
1               5                   10  


<210>  76
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  76

Asp Ser Phe Tyr Asp Ile Leu Thr Gly Pro Val Tyr His Tyr Tyr Gly 
1               5                   10                  15      


Met Asp Val 
            


<210>  77
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  77

Thr Gly Thr Ser Asn Asp Val Gly Val Tyr Asn His Val Ser 
1               5                   10                  


<210>  78
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  78

Cys Ser Tyr Val Gly Asn Ser Ala Trp Val 
1               5                   10  


<210>  79
<211>  443
<212>  PRT
<213>  Homo sapiens

<400>  79

Ala Thr Gly Gly Ala Cys Thr Gly Gly Ala Cys Cys Thr Gly Gly Ala 
1               5                   10                  15      


Gly Gly Gly Thr Cys Cys Thr Cys Thr Thr Thr Thr Thr Gly Gly Thr 
            20                  25                  30          


Gly Gly Cys Ala Gly Cys Ala Gly Cys Cys Ala Cys Ala Gly Gly Thr 
        35                  40                  45              


Gly Cys Cys Cys Ala Cys Thr Cys Cys Cys Ala Gly Gly Thr Cys Cys 
    50                  55                  60                  


Ala Gly Cys Thr Thr Gly Thr Gly Cys Ala Gly Thr Cys Thr Gly Gly 
65                  70                  75                  80  


Gly Gly Cys Thr Gly Ala Gly Gly Thr Gly Ala Ala Gly Ala Ala Gly 
                85                  90                  95      


Cys Cys Thr Gly Gly Gly Gly Cys Cys Thr Cys Ala Gly Thr Gly Ala 
            100                 105                 110         


Ala Gly Gly Thr Thr Thr Cys Cys Thr Gly Cys Ala Gly Gly Gly Cys 
        115                 120                 125             


Thr Thr Cys Thr Gly Gly Ala Thr Ala Cys Ala Cys Cys Thr Thr Cys 
    130                 135                 140                 


Ala Gly Thr Ala Ala Thr Thr Ala Thr Gly Cys Thr Ala Thr Gly Cys 
145                 150                 155                 160 


Ala Thr Thr Gly Gly Gly Thr Gly Cys Gly Cys Cys Ala Gly Gly Cys 
                165                 170                 175     


Cys Cys Cys Cys Gly Gly Ala Cys Ala Ala Ala Gly Gly Cys Thr Thr 
            180                 185                 190         


Gly Ala Gly Thr Gly Gly Ala Thr Gly Gly Gly Ala Thr Gly Gly Ala 
        195                 200                 205             


Thr Cys Ala Ala Cys Gly Cys Thr Gly Gly Cys Ala Ala Thr Gly Gly 
    210                 215                 220                 


Thr Thr Ala Cys Ala Cys Ala Ala Ala Ala Thr Ala Thr Thr Cys Ala 
225                 230                 235                 240 


Cys Ala Gly Ala Ala Gly Thr Thr Cys Cys Ala Gly Gly Ala Cys Ala 
                245                 250                 255     


Gly Ala Gly Thr Cys Ala Cys Cys Ala Thr Thr Ala Cys Cys Ala Gly 
            260                 265                 270         


Gly Gly Ala Cys Ala Cys Ala Thr Cys Cys Gly Cys Gly Ala Cys Cys 
        275                 280                 285             


Ala Cys Ala Gly Cys Cys Thr Ala Cys Ala Thr Gly Gly Ala Ala Cys 
    290                 295                 300                 


Thr Gly Ala Gly Cys Ala Gly Cys Cys Thr Gly Ala Gly Ala Thr Cys 
305                 310                 315                 320 


Thr Gly Ala Ala Gly Ala Cys Ala Cys Gly Gly Cys Thr Ala Thr Gly 
                325                 330                 335     


Thr Ala Thr Thr Ala Cys Thr Gly Thr Thr Cys Gly Ala Gly Ala Gly 
            340                 345                 350         


Ala Thr Thr Cys Thr Thr Thr Thr Thr Ala Cys Gly Ala Thr Ala Thr 
        355                 360                 365             


Thr Thr Thr Gly Ala Cys Thr Gly Gly Gly Cys Cys Ala Gly Thr Cys 
    370                 375                 380                 


Thr Ala Thr Cys Ala Cys Thr Ala Cys Thr Ala Cys Gly Gly Thr Ala 
385                 390                 395                 400 


Thr Gly Gly Ala Cys Gly Thr Cys Thr Gly Gly Gly Gly Cys Cys Ala 
                405                 410                 415     


Ala Gly Gly Gly Ala Cys Cys Ala Cys Gly Gly Thr Cys Ala Cys Cys 
            420                 425                 430         


Gly Thr Cys Thr Cys Cys Thr Cys Ala Gly Cys 
        435                 440             


<210>  80
<211>  128
<212>  PRT
<213>  Homo sapiens

<400>  80

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Arg Ala Ser Gly Tyr Thr Phe Ser Asn Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Ala Gly Asn Gly Tyr Thr Lys Tyr Ser Gln Lys Phe 
    50                  55                  60                  


Gln Asp Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Thr Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Asp Ser Phe Tyr Asp Ile Leu Thr Gly Pro Val Tyr His Tyr 
            100                 105                 110         


Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125             


<210>  81
<211>  389
<212>  PRT
<213>  Homo sapiens

<400>  81

Ala Thr Gly Gly Cys Cys Thr Gly Gly Gly Cys Thr Cys Thr Gly Cys 
1               5                   10                  15      


Thr Gly Cys Thr Cys Cys Thr Cys Ala Ala Cys Cys Thr Cys Cys Thr 
            20                  25                  30          


Cys Ala Cys Thr Cys Ala Gly Gly Ala Cys Ala Cys Ala Gly Gly Gly 
        35                  40                  45              


Thr Cys Cys Thr Gly Gly Gly Cys Cys Cys Ala Gly Thr Cys Thr Gly 
    50                  55                  60                  


Cys Cys Cys Thr Gly Ala Cys Thr Cys Ala Gly Cys Cys Thr Gly Ala 
65                  70                  75                  80  


Cys Thr Cys Cys Gly Thr Gly Thr Cys Thr Gly Gly Gly Thr Cys Thr 
                85                  90                  95      


Cys Cys Thr Gly Gly Ala Cys Ala Gly Thr Cys Gly Ala Thr Cys Ala 
            100                 105                 110         


Cys Cys Ala Thr Cys Thr Cys Cys Thr Gly Cys Ala Cys Thr Gly Gly 
        115                 120                 125             


Ala Ala Cys Cys Ala Gly Cys Ala Ala Thr Gly Ala Thr Gly Thr Thr 
    130                 135                 140                 


Gly Gly Thr Gly Thr Thr Thr Ala Thr Ala Ala Cys Cys Ala Thr Gly 
145                 150                 155                 160 


Thr Cys Thr Cys Cys Thr Gly Gly Thr Ala Cys Cys Ala Ala Cys Ala 
                165                 170                 175     


Gly Cys Ala Cys Cys Cys Ala Gly Gly Cys Ala Ala Ala Gly Cys Cys 
            180                 185                 190         


Cys Cys Cys Ala Ala Ala Cys Thr Cys Ala Thr Gly Ala Thr Thr Thr 
        195                 200                 205             


Ala Thr Gly Ala Thr Gly Thr Cys Ala Gly Thr Ala Ala Gly Cys Gly 
    210                 215                 220                 


Gly Cys Cys Cys Thr Cys Ala Gly Gly Gly Gly Thr Thr Thr Cys Thr 
225                 230                 235                 240 


Ala Ala Thr Cys Gly Cys Thr Thr Cys Thr Cys Thr Gly Gly Cys Thr 
                245                 250                 255     


Cys Cys Ala Ala Gly Thr Cys Thr Gly Gly Cys Ala Ala Cys Ala Cys 
            260                 265                 270         


Gly Gly Cys Cys Thr Cys Cys Cys Thr Gly Ala Cys Ala Ala Thr Cys 
        275                 280                 285             


Thr Cys Thr Gly Gly Gly Cys Thr Cys Cys Ala Gly Gly Cys Thr Gly 
    290                 295                 300                 


Ala Gly Gly Ala Cys Gly Ala Gly Gly Cys Thr Gly Ala Thr Thr Ala 
305                 310                 315                 320 


Thr Thr Ala Cys Thr Gly Cys Thr Gly Cys Thr Cys Ala Thr Ala Thr 
                325                 330                 335     


Gly Thr Ala Gly Gly Thr Ala Ala Thr Ala Gly Cys Gly Cys Thr Thr 
            340                 345                 350         


Gly Gly Gly Thr Gly Thr Thr Cys Gly Gly Cys Gly Gly Ala Gly Gly 
        355                 360                 365             


Gly Ala Cys Cys Ala Ala Ala Cys Thr Gly Ala Cys Cys Gly Thr Cys 
    370                 375                 380                 


Cys Thr Ala Gly Gly 
385                 


<210>  82
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  82

Gln Ser Ala Leu Thr Gln Pro Asp Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Asn Asp Val Gly Val Tyr 
            20                  25                  30          


Asn His Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Asp Val Ser Lys Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Cys Ser Tyr Val Gly Asn 
                85                  90                  95      


Ser Ala Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  83
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  83

Cys Ser Tyr Val Gly Ser Ser Ala Trp Val 
1               5                   10  


<210>  84
<211>  443
<212>  PRT
<213>  Homo sapiens

<400>  84

Ala Thr Gly Gly Ala Cys Thr Gly Gly Ala Cys Cys Thr Gly Gly Ala 
1               5                   10                  15      


Gly Gly Gly Thr Cys Cys Thr Cys Thr Thr Thr Thr Thr Gly Gly Thr 
            20                  25                  30          


Gly Gly Cys Ala Gly Cys Ala Gly Cys Cys Ala Cys Ala Gly Gly Thr 
        35                  40                  45              


Gly Cys Cys Cys Ala Cys Thr Cys Cys Cys Ala Gly Gly Thr Cys Cys 
    50                  55                  60                  


Ala Gly Cys Thr Thr Gly Thr Gly Cys Ala Gly Thr Cys Thr Gly Gly 
65                  70                  75                  80  


Gly Gly Cys Thr Gly Ala Gly Gly Thr Gly Ala Ala Gly Ala Ala Gly 
                85                  90                  95      


Cys Cys Thr Gly Gly Gly Gly Cys Cys Thr Cys Ala Gly Thr Gly Ala 
            100                 105                 110         


Ala Gly Gly Thr Thr Thr Cys Cys Thr Gly Cys Ala Gly Gly Gly Cys 
        115                 120                 125             


Thr Thr Cys Thr Gly Gly Ala Thr Ala Cys Ala Cys Cys Thr Thr Cys 
    130                 135                 140                 


Ala Cys Thr Ala Ala Cys Thr Ala Thr Gly Cys Thr Ala Thr Gly Cys 
145                 150                 155                 160 


Ala Thr Thr Gly Gly Gly Thr Gly Cys Gly Cys Cys Ala Gly Gly Cys 
                165                 170                 175     


Cys Cys Cys Cys Gly Gly Ala Cys Ala Ala Ala Gly Gly Cys Thr Thr 
            180                 185                 190         


Gly Ala Gly Thr Gly Gly Ala Thr Gly Gly Gly Ala Thr Gly Gly Ala 
        195                 200                 205             


Thr Cys Ala Ala Cys Gly Cys Thr Gly Gly Cys Ala Ala Thr Gly Gly 
    210                 215                 220                 


Thr Thr Ala Cys Ala Cys Ala Ala Ala Gly Thr Ala Thr Thr Cys Ala 
225                 230                 235                 240 


Cys Ala Gly Ala Ala Gly Thr Thr Cys Cys Ala Gly Gly Ala Cys Ala 
                245                 250                 255     


Gly Ala Gly Thr Cys Ala Cys Cys Ala Thr Thr Ala Cys Cys Ala Gly 
            260                 265                 270         


Gly Gly Ala Cys Ala Cys Ala Thr Cys Cys Gly Cys Gly Ala Cys Cys 
        275                 280                 285             


Ala Cys Ala Gly Cys Cys Cys Ala Cys Ala Thr Gly Gly Ala Ala Cys 
    290                 295                 300                 


Thr Gly Ala Gly Cys Ala Gly Cys Cys Thr Gly Ala Gly Ala Thr Cys 
305                 310                 315                 320 


Thr Gly Ala Ala Gly Ala Cys Ala Cys Gly Gly Cys Thr Ala Thr Gly 
                325                 330                 335     


Thr Ala Thr Thr Ala Cys Thr Gly Thr Gly Cys Gly Ala Gly Ala Gly 
            340                 345                 350         


Ala Thr Thr Cys Thr Thr Thr Thr Thr Ala Cys Gly Ala Thr Ala Thr 
        355                 360                 365             


Thr Thr Thr Gly Ala Cys Thr Gly Gly Gly Cys Cys Ala Gly Thr Cys 
    370                 375                 380                 


Thr Ala Thr Cys Ala Cys Thr Ala Cys Thr Ala Cys Gly Gly Thr Ala 
385                 390                 395                 400 


Thr Gly Gly Ala Cys Gly Thr Cys Thr Gly Gly Gly Gly Cys Cys Ala 
                405                 410                 415     


Ala Gly Gly Gly Ala Cys Cys Ala Cys Gly Gly Thr Cys Ala Cys Cys 
            420                 425                 430         


Gly Thr Cys Thr Cys Cys Thr Cys Ala Gly Cys 
        435                 440             


<210>  85
<211>  128
<212>  PRT
<213>  Homo sapiens

<400>  85

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Arg Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Ala Gly Asn Gly Tyr Thr Lys Tyr Ser Gln Lys Phe 
    50                  55                  60                  


Gln Asp Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Thr Thr Ala His 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Ser Phe Tyr Asp Ile Leu Thr Gly Pro Val Tyr His Tyr 
            100                 105                 110         


Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125             


<210>  86
<211>  389
<212>  PRT
<213>  Homo sapiens

<400>  86

Ala Thr Gly Gly Cys Cys Thr Gly Gly Gly Cys Thr Cys Thr Gly Cys 
1               5                   10                  15      


Thr Gly Cys Thr Cys Cys Thr Cys Ala Ala Cys Cys Thr Cys Cys Thr 
            20                  25                  30          


Cys Ala Cys Thr Cys Ala Gly Gly Ala Cys Ala Cys Ala Gly Gly Gly 
        35                  40                  45              


Thr Cys Cys Thr Gly Gly Gly Cys Cys Cys Ala Gly Thr Cys Thr Gly 
    50                  55                  60                  


Cys Cys Cys Thr Gly Ala Cys Thr Cys Ala Gly Cys Cys Thr Gly Ala 
65                  70                  75                  80  


Cys Thr Cys Cys Gly Thr Gly Thr Cys Thr Gly Gly Gly Thr Cys Thr 
                85                  90                  95      


Cys Cys Thr Gly Gly Ala Cys Ala Gly Thr Cys Gly Ala Thr Cys Ala 
            100                 105                 110         


Cys Cys Ala Thr Cys Thr Cys Cys Thr Gly Cys Ala Cys Thr Gly Gly 
        115                 120                 125             


Ala Ala Cys Cys Ala Gly Cys Ala Ala Thr Gly Ala Thr Gly Thr Thr 
    130                 135                 140                 


Gly Gly Thr Gly Thr Thr Thr Ala Thr Ala Ala Cys Cys Ala Thr Gly 
145                 150                 155                 160 


Thr Cys Thr Cys Cys Thr Gly Gly Thr Ala Cys Cys Ala Ala Cys Ala 
                165                 170                 175     


Gly Cys Ala Cys Cys Cys Ala Gly Gly Cys Ala Ala Ala Gly Cys Cys 
            180                 185                 190         


Cys Cys Cys Ala Ala Ala Cys Thr Cys Ala Thr Gly Ala Thr Thr Thr 
        195                 200                 205             


Ala Thr Gly Ala Thr Gly Thr Cys Ala Gly Thr Ala Ala Gly Cys Gly 
    210                 215                 220                 


Gly Cys Cys Cys Thr Cys Ala Gly Gly Gly Gly Thr Thr Thr Cys Thr 
225                 230                 235                 240 


Ala Ala Thr Cys Gly Cys Thr Thr Cys Thr Cys Thr Gly Gly Cys Thr 
                245                 250                 255     


Cys Cys Ala Ala Gly Thr Cys Thr Gly Gly Cys Ala Ala Cys Ala Cys 
            260                 265                 270         


Gly Gly Cys Cys Thr Cys Cys Cys Thr Gly Ala Cys Ala Ala Thr Cys 
        275                 280                 285             


Thr Cys Thr Gly Gly Gly Cys Thr Cys Cys Ala Gly Gly Cys Thr Gly 
    290                 295                 300                 


Ala Gly Gly Ala Cys Gly Ala Gly Gly Cys Thr Gly Ala Thr Thr Ala 
305                 310                 315                 320 


Thr Thr Ala Cys Thr Gly Cys Thr Gly Cys Thr Cys Ala Thr Ala Thr 
                325                 330                 335     


Gly Thr Ala Gly Gly Thr Ala Gly Thr Ala Gly Cys Gly Cys Thr Thr 
            340                 345                 350         


Gly Gly Gly Thr Gly Thr Thr Cys Gly Gly Cys Gly Gly Ala Gly Gly 
        355                 360                 365             


Gly Ala Cys Cys Ala Ala Thr Cys Thr Gly Ala Cys Cys Gly Thr Cys 
    370                 375                 380                 


Cys Thr Ala Gly Gly 
385                 


<210>  87
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  87

Gln Ser Ala Leu Thr Gln Pro Asp Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Asn Asp Val Gly Val Tyr 
            20                  25                  30          


Asn His Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Asp Val Ser Lys Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Cys Ser Tyr Val Gly Ser 
                85                  90                  95      


Ser Ala Trp Val Phe Gly Gly Gly Thr Asn Leu Thr Val Leu 
            100                 105                 110 


<210>  88
<211>  443
<212>  PRT
<213>  Homo sapiens

<400>  88

Ala Thr Gly Gly Ala Cys Thr Gly Gly Ala Cys Cys Thr Gly Gly Ala 
1               5                   10                  15      


Gly Gly Gly Thr Cys Cys Thr Cys Thr Thr Thr Thr Thr Gly Gly Thr 
            20                  25                  30          


Gly Gly Cys Ala Gly Cys Ala Gly Cys Cys Ala Cys Ala Gly Gly Thr 
        35                  40                  45              


Gly Cys Cys Cys Ala Cys Thr Cys Cys Cys Ala Gly Gly Thr Cys Cys 
    50                  55                  60                  


Ala Gly Cys Thr Thr Gly Thr Gly Cys Ala Gly Thr Cys Thr Gly Gly 
65                  70                  75                  80  


Gly Gly Cys Thr Gly Ala Gly Gly Thr Gly Ala Ala Gly Ala Ala Gly 
                85                  90                  95      


Cys Cys Thr Gly Gly Gly Gly Cys Cys Thr Cys Ala Gly Thr Gly Ala 
            100                 105                 110         


Ala Gly Gly Thr Thr Thr Cys Cys Thr Gly Cys Ala Gly Gly Gly Cys 
        115                 120                 125             


Thr Thr Cys Thr Gly Gly Ala Thr Ala Cys Ala Cys Cys Thr Thr Cys 
    130                 135                 140                 


Ala Cys Thr Ala Ala Cys Thr Ala Thr Gly Cys Thr Ala Thr Gly Cys 
145                 150                 155                 160 


Ala Thr Thr Gly Gly Gly Thr Gly Cys Gly Cys Cys Ala Gly Gly Cys 
                165                 170                 175     


Cys Cys Cys Cys Gly Gly Ala Cys Ala Ala Ala Gly Gly Cys Thr Thr 
            180                 185                 190         


Gly Ala Gly Thr Gly Gly Ala Thr Gly Gly Gly Ala Thr Gly Gly Ala 
        195                 200                 205             


Thr Cys Ala Ala Cys Gly Cys Thr Gly Gly Cys Ala Ala Thr Gly Gly 
    210                 215                 220                 


Thr Thr Ala Cys Ala Cys Ala Ala Ala Ala Thr Ala Thr Thr Cys Ala 
225                 230                 235                 240 


Cys Ala Gly Ala Ala Gly Thr Thr Cys Cys Ala Gly Gly Ala Cys Ala 
                245                 250                 255     


Gly Ala Thr Thr Cys Ala Cys Cys Ala Thr Thr Ala Cys Cys Ala Gly 
            260                 265                 270         


Gly Gly Ala Cys Ala Cys Ala Thr Cys Cys Gly Cys Gly Ala Cys Cys 
        275                 280                 285             


Ala Cys Ala Gly Cys Cys Thr Ala Cys Ala Thr Gly Gly Ala Ala Cys 
    290                 295                 300                 


Thr Gly Ala Gly Cys Ala Gly Cys Cys Thr Gly Ala Gly Ala Thr Cys 
305                 310                 315                 320 


Thr Gly Ala Ala Gly Ala Cys Ala Cys Gly Gly Cys Thr Gly Thr Ala 
                325                 330                 335     


Thr Ala Thr Thr Ala Cys Thr Gly Thr Gly Cys Gly Ala Gly Ala Gly 
            340                 345                 350         


Ala Thr Thr Cys Thr Thr Thr Thr Thr Ala Cys Gly Ala Thr Ala Thr 
        355                 360                 365             


Thr Thr Thr Gly Ala Cys Thr Gly Gly Gly Cys Cys Ala Gly Thr Cys 
    370                 375                 380                 


Thr Ala Thr Cys Ala Cys Thr Ala Cys Thr Ala Cys Gly Gly Thr Ala 
385                 390                 395                 400 


Thr Gly Gly Ala Cys Gly Thr Cys Thr Gly Gly Gly Gly Cys Cys Ala 
                405                 410                 415     


Ala Gly Gly Gly Ala Cys Cys Ala Cys Gly Gly Thr Cys Ala Cys Cys 
            420                 425                 430         


Gly Thr Cys Thr Cys Cys Thr Cys Ala Gly Cys 
        435                 440             


<210>  89
<211>  128
<212>  PRT
<213>  Homo sapiens

<400>  89

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Arg Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Ala Gly Asn Gly Tyr Thr Lys Tyr Ser Gln Lys Phe 
    50                  55                  60                  


Gln Asp Arg Phe Thr Ile Thr Arg Asp Thr Ser Ala Thr Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Ser Phe Tyr Asp Ile Leu Thr Gly Pro Val Tyr His Tyr 
            100                 105                 110         


Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125             


<210>  90
<211>  389
<212>  PRT
<213>  Homo sapiens

<400>  90

Ala Thr Gly Gly Cys Cys Thr Gly Gly Gly Cys Thr Cys Thr Gly Cys 
1               5                   10                  15      


Thr Gly Cys Thr Cys Cys Thr Cys Ala Ala Cys Cys Thr Cys Cys Thr 
            20                  25                  30          


Cys Ala Cys Thr Cys Ala Gly Gly Ala Cys Ala Cys Ala Gly Gly Gly 
        35                  40                  45              


Thr Cys Cys Thr Gly Gly Gly Cys Cys Cys Ala Gly Thr Cys Thr Gly 
    50                  55                  60                  


Cys Cys Cys Thr Gly Ala Cys Thr Cys Ala Gly Cys Cys Thr Gly Ala 
65                  70                  75                  80  


Cys Thr Cys Cys Gly Thr Gly Thr Cys Thr Gly Gly Gly Thr Cys Thr 
                85                  90                  95      


Cys Cys Thr Gly Gly Ala Cys Ala Gly Thr Cys Gly Ala Thr Cys Ala 
            100                 105                 110         


Cys Cys Ala Thr Cys Thr Cys Cys Thr Gly Cys Ala Cys Thr Gly Gly 
        115                 120                 125             


Ala Ala Cys Cys Ala Gly Cys Ala Ala Thr Gly Ala Thr Gly Thr Thr 
    130                 135                 140                 


Gly Gly Thr Gly Thr Thr Thr Ala Thr Ala Ala Cys Cys Ala Thr Gly 
145                 150                 155                 160 


Thr Cys Thr Cys Cys Thr Gly Gly Thr Ala Cys Cys Ala Ala Cys Ala 
                165                 170                 175     


Gly Cys Ala Cys Cys Cys Ala Gly Gly Cys Ala Ala Ala Gly Cys Cys 
            180                 185                 190         


Cys Cys Cys Ala Ala Ala Cys Thr Cys Ala Thr Gly Ala Thr Thr Thr 
        195                 200                 205             


Ala Thr Gly Ala Thr Gly Thr Cys Ala Gly Thr Ala Ala Gly Cys Gly 
    210                 215                 220                 


Gly Cys Cys Cys Thr Cys Ala Gly Gly Gly Gly Thr Thr Thr Cys Thr 
225                 230                 235                 240 


Ala Ala Thr Cys Gly Cys Thr Thr Cys Thr Cys Thr Gly Gly Cys Thr 
                245                 250                 255     


Cys Cys Ala Ala Gly Thr Cys Thr Gly Gly Cys Ala Ala Cys Ala Cys 
            260                 265                 270         


Gly Gly Cys Cys Thr Cys Cys Cys Thr Gly Ala Cys Ala Ala Thr Cys 
        275                 280                 285             


Thr Cys Thr Gly Gly Gly Cys Thr Cys Cys Ala Gly Gly Cys Thr Gly 
    290                 295                 300                 


Ala Gly Gly Ala Cys Gly Ala Gly Ala Gly Thr Gly Ala Thr Thr Ala 
305                 310                 315                 320 


Thr Thr Ala Cys Thr Gly Cys Thr Gly Cys Thr Cys Ala Thr Ala Thr 
                325                 330                 335     


Gly Cys Ala Gly Gly Thr Ala Gly Thr Ala Gly Cys Ala Cys Thr Thr 
            340                 345                 350         


Gly Gly Gly Thr Gly Thr Thr Cys Gly Gly Cys Gly Gly Ala Gly Gly 
        355                 360                 365             


Gly Ala Cys Cys Ala Ala Gly Cys Thr Gly Ala Cys Cys Gly Thr Cys 
    370                 375                 380                 


Cys Thr Ala Gly Gly 
385                 


<210>  91
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  91

Gln Ser Ala Leu Thr Gln Pro Asp Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Asn Asp Val Gly Val Tyr 
            20                  25                  30          


Asn His Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Asp Val Ser Lys Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ser Asp Tyr Tyr Cys Cys Ser Tyr Ala Gly Ser 
                85                  90                  95      


Ser Thr Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  92
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  92

Thr Gly Thr Ser Ser Asp Val Gly Ala Tyr Lys Tyr Val Ser 
1               5                   10                  


<210>  93
<211>  437
<212>  PRT
<213>  Homo sapiens

<400>  93

Ala Thr Gly Gly Ala Cys Thr Gly Gly Ala Cys Cys Thr Gly Gly Ala 
1               5                   10                  15      


Gly Gly Ala Thr Cys Cys Thr Cys Thr Thr Thr Thr Thr Gly Gly Thr 
            20                  25                  30          


Gly Gly Cys Ala Gly Cys Ala Gly Cys Cys Gly Cys Ala Gly Gly Thr 
        35                  40                  45              


Gly Cys Cys Cys Ala Cys Thr Cys Cys Cys Ala Gly Gly Thr Cys Cys 
    50                  55                  60                  


Ala Gly Cys Thr Thr Gly Thr Gly Cys Ala Gly Thr Cys Thr Gly Gly 
65                  70                  75                  80  


Gly Gly Cys Thr Gly Ala Gly Gly Thr Gly Ala Ala Gly Ala Ala Gly 
                85                  90                  95      


Cys Cys Thr Gly Gly Gly Gly Cys Cys Thr Cys Ala Gly Thr Gly Ala 
            100                 105                 110         


Ala Gly Gly Thr Thr Thr Cys Cys Thr Gly Cys Ala Ala Gly Gly Cys 
        115                 120                 125             


Thr Thr Cys Thr Gly Gly Ala Thr Thr Cys Ala Cys Cys Thr Thr Cys 
    130                 135                 140                 


Ala Cys Thr Gly Ala Cys Thr Ala Cys Gly Cys Thr Ala Thr Gly Cys 
145                 150                 155                 160 


Ala Thr Thr Gly Gly Gly Thr Gly Cys Gly Cys Cys Ala Gly Gly Cys 
                165                 170                 175     


Cys Cys Cys Cys Gly Gly Ala Cys Ala Ala Ala Gly Gly Cys Thr Thr 
            180                 185                 190         


Gly Ala Gly Thr Gly Gly Ala Thr Gly Gly Gly Thr Thr Gly Gly Ala 
        195                 200                 205             


Thr Cys Ala Ala Cys Gly Cys Thr Gly Gly Cys Ala Ala Thr Gly Gly 
    210                 215                 220                 


Thr Thr Ala Cys Ala Cys Ala Ala Ala Ala Thr Ala Thr Thr Cys Ala 
225                 230                 235                 240 


Cys Ala Gly Ala Ala Gly Thr Thr Cys Cys Ala Gly Gly Ala Cys Ala 
                245                 250                 255     


Gly Ala Cys Thr Cys Ala Cys Cys Ala Thr Thr Ala Cys Cys Ala Gly 
            260                 265                 270         


Gly Gly Ala Cys Ala Cys Ala Thr Thr Cys Gly Cys Gly Ala Gly Cys 
        275                 280                 285             


Ala Cys Ala Gly Thr Cys Thr Ala Cys Ala Thr Gly Gly Ala Gly Cys 
    290                 295                 300                 


Thr Gly Ala Gly Cys Ala Gly Cys Cys Thr Gly Ala Gly Ala Thr Cys 
305                 310                 315                 320 


Thr Gly Ala Ala Gly Ala Cys Ala Cys Gly Ala Cys Thr Gly Thr Gly 
                325                 330                 335     


Thr Ala Thr Thr Ala Cys Thr Gly Thr Gly Cys Gly Ala Gly Ala Gly 
            340                 345                 350         


Ala Thr Gly Gly Gly Thr Thr Thr Thr Gly Thr Cys Cys Thr Ala Gly 
        355                 360                 365             


Thr Ala Ala Cys Ala Cys Thr Thr Gly Thr Thr Cys Thr Gly Gly Thr 
    370                 375                 380                 


Thr Ala Cys Thr Ala Cys Gly Gly Thr Ala Thr Gly Gly Ala Cys Gly 
385                 390                 395                 400 


Thr Cys Thr Gly Gly Gly Gly Cys Cys Ala Ala Gly Gly Gly Ala Cys 
                405                 410                 415     


Cys Ala Cys Gly Gly Thr Cys Ala Cys Cys Gly Thr Cys Thr Cys Cys 
            420                 425                 430         


Thr Cys Ala Gly Cys 
        435         


<210>  94
<211>  126
<212>  PRT
<213>  Homo sapiens

<400>  94

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Ala Gly Asn Gly Tyr Thr Lys Tyr Ser Gln Lys Phe 
    50                  55                  60                  


Gln Asp Arg Leu Thr Ile Thr Arg Asp Thr Phe Ala Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Thr Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Phe Cys Pro Ser Asn Thr Cys Ser Gly Tyr Tyr Gly 
            100                 105                 110         


Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125     


<210>  95
<211>  389
<212>  PRT
<213>  Homo sapiens

<400>  95

Ala Thr Gly Gly Cys Cys Thr Gly Gly Gly Cys Thr Cys Thr Gly Cys 
1               5                   10                  15      


Thr Gly Cys Thr Cys Cys Thr Cys Ala Ala Cys Cys Thr Cys Cys Thr 
            20                  25                  30          


Cys Ala Cys Thr Cys Ala Gly Gly Ala Cys Ala Cys Ala Gly Gly Gly 
        35                  40                  45              


Thr Cys Cys Thr Gly Gly Gly Cys Cys Cys Ala Gly Thr Cys Thr Gly 
    50                  55                  60                  


Cys Cys Cys Thr Gly Ala Cys Thr Cys Ala Gly Cys Cys Thr Gly Cys 
65                  70                  75                  80  


Cys Thr Cys Cys Gly Thr Gly Thr Cys Thr Gly Gly Gly Thr Cys Thr 
                85                  90                  95      


Cys Cys Thr Gly Gly Ala Cys Ala Gly Thr Cys Gly Ala Thr Cys Ala 
            100                 105                 110         


Cys Cys Ala Thr Cys Thr Cys Cys Thr Gly Cys Ala Cys Thr Gly Gly 
        115                 120                 125             


Ala Ala Cys Cys Ala Gly Cys Ala Gly Thr Gly Ala Thr Gly Thr Thr 
    130                 135                 140                 


Gly Gly Thr Gly Cys Thr Thr Ala Thr Ala Ala Gly Thr Ala Thr Gly 
145                 150                 155                 160 


Thr Cys Thr Cys Cys Thr Gly Gly Thr Ala Cys Cys Ala Ala Cys Ala 
                165                 170                 175     


Gly Cys Ala Cys Cys Cys Ala Gly Gly Cys Ala Ala Ala Gly Cys Cys 
            180                 185                 190         


Cys Cys Cys Ala Ala Ala Cys Thr Cys Ala Thr Gly Ala Thr Thr Thr 
        195                 200                 205             


Ala Thr Gly Ala Thr Gly Thr Cys Ala Ala Thr Ala Cys Gly Cys Gly 
    210                 215                 220                 


Gly Cys Cys Cys Thr Cys Ala Gly Gly Gly Gly Thr Thr Thr Cys Thr 
225                 230                 235                 240 


Ala Cys Thr Cys Gly Cys Thr Thr Cys Thr Cys Thr Gly Cys Cys Thr 
                245                 250                 255     


Cys Cys Ala Ala Gly Thr Cys Thr Gly Gly Cys Ala Ala Cys Ala Cys 
            260                 265                 270         


Gly Gly Cys Cys Thr Cys Cys Cys Thr Gly Ala Cys Ala Gly Thr Cys 
        275                 280                 285             


Thr Cys Thr Gly Gly Gly Cys Thr Cys Cys Ala Gly Gly Cys Thr Gly 
    290                 295                 300                 


Ala Gly Gly Ala Cys Gly Ala Gly Gly Cys Thr Gly Thr Thr Thr Ala 
305                 310                 315                 320 


Thr Thr Ala Cys Thr Gly Cys Thr Cys Cys Thr Cys Ala Thr Ala Thr 
                325                 330                 335     


Gly Cys Ala Gly Gly Thr Ala Gly Thr Ala Gly Cys Ala Cys Thr Thr 
            340                 345                 350         


Gly Gly Gly Thr Gly Thr Thr Cys Gly Gly Cys Gly Gly Ala Gly Gly 
        355                 360                 365             


Gly Ala Cys Cys Ala Ala Gly Cys Thr Gly Ala Cys Cys Gly Thr Cys 
    370                 375                 380                 


Cys Thr Ala Gly Gly 
385                 


<210>  96
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  96

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Ala Tyr 
            20                  25                  30          


Lys Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Asp Val Asn Thr Arg Pro Ser Gly Val Ser Thr Arg Phe 
    50                  55                  60                  


Ser Ala Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Val Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Val Tyr Tyr Cys Ser Ser Tyr Ala Gly Ser 
                85                  90                  95      


Ser Thr Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  97
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  97

Gly Phe Thr Phe Ile Ser Tyr Ala Met His 
1               5                   10  


<210>  98
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  98

Trp Ile Asn Ala Gly Asp Gly His Thr Lys Tyr Ser Gln Lys Phe Gln 
1               5                   10                  15      


Asp 
    


<210>  99
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  99

Asp Gly Phe Cys Thr Thr Thr Thr Cys Ser Asp His Tyr Gly Met Asp 
1               5                   10                  15      


Val 
    


<210>  100
<211>  437
<212>  PRT
<213>  Homo sapiens

<400>  100

Ala Thr Gly Gly Ala Cys Thr Gly Gly Ala Cys Cys Thr Gly Gly Ala 
1               5                   10                  15      


Gly Gly Ala Thr Cys Cys Thr Cys Thr Thr Thr Thr Thr Gly Gly Thr 
            20                  25                  30          


Gly Gly Cys Ala Gly Cys Ala Gly Cys Cys Ala Cys Ala Gly Gly Thr 
        35                  40                  45              


Gly Cys Cys Cys Ala Cys Thr Cys Cys Cys Ala Gly Gly Thr Cys Cys 
    50                  55                  60                  


Ala Gly Cys Thr Thr Gly Thr Gly Cys Ala Gly Thr Cys Thr Gly Gly 
65                  70                  75                  80  


Gly Gly Cys Thr Gly Ala Gly Gly Thr Gly Ala Ala Gly Ala Ala Gly 
                85                  90                  95      


Cys Cys Thr Gly Gly Gly Gly Cys Cys Thr Cys Ala Gly Thr Gly Ala 
            100                 105                 110         


Gly Gly Gly Thr Thr Thr Cys Cys Thr Gly Cys Ala Ala Gly Gly Cys 
        115                 120                 125             


Thr Thr Cys Thr Gly Gly Ala Thr Thr Cys Ala Cys Cys Thr Thr Cys 
    130                 135                 140                 


Ala Thr Thr Ala Gly Thr Thr Ala Thr Gly Cys Thr Ala Thr Gly Cys 
145                 150                 155                 160 


Ala Thr Thr Gly Gly Gly Thr Gly Cys Gly Cys Cys Ala Gly Gly Cys 
                165                 170                 175     


Cys Cys Cys Cys Gly Gly Ala Cys Ala Ala Gly Gly Gly Cys Thr Thr 
            180                 185                 190         


Gly Ala Gly Thr Gly Gly Ala Thr Gly Gly Gly Ala Thr Gly Gly Ala 
        195                 200                 205             


Thr Cys Ala Ala Cys Gly Cys Thr Gly Gly Cys Gly Ala Thr Gly Gly 
    210                 215                 220                 


Thr Cys Ala Cys Ala Cys Ala Ala Ala Ala Thr Ala Thr Thr Cys Ala 
225                 230                 235                 240 


Cys Ala Gly Ala Ala Gly Thr Thr Cys Cys Ala Gly Gly Ala Cys Ala 
                245                 250                 255     


Gly Ala Gly Thr Cys Gly Cys Cys Ala Thr Thr Ala Cys Cys Ala Gly 
            260                 265                 270         


Gly Gly Ala Cys Ala Cys Ala Thr Cys Cys Gly Cys Gly Ala Cys Cys 
        275                 280                 285             


Ala Cys Ala Gly Thr Cys Thr Ala Cys Ala Thr Gly Gly Ala Cys Cys 
    290                 295                 300                 


Thr Gly Ala Gly Cys Ala Gly Cys Cys Thr Gly Ala Gly Ala Thr Cys 
305                 310                 315                 320 


Thr Gly Ala Ala Gly Ala Cys Ala Cys Gly Gly Cys Thr Gly Thr Gly 
                325                 330                 335     


Thr Ala Thr Thr Ala Cys Thr Gly Thr Thr Cys Gly Ala Gly Ala Gly 
            340                 345                 350         


Ala Thr Gly Gly Ala Thr Thr Thr Thr Gly Thr Ala Cys Thr Ala Cys 
        355                 360                 365             


Thr Ala Cys Cys Ala Cys Cys Thr Gly Thr Thr Cys Cys Gly Ala Cys 
    370                 375                 380                 


Cys Ala Cys Thr Ala Cys Gly Gly Thr Ala Thr Gly Gly Ala Cys Gly 
385                 390                 395                 400 


Thr Cys Thr Gly Gly Gly Gly Cys Cys Ala Ala Gly Gly Gly Ala Cys 
                405                 410                 415     


Cys Ala Cys Gly Gly Thr Cys Ala Cys Cys Gly Thr Cys Thr Cys Cys 
            420                 425                 430         


Thr Cys Ala Gly Cys 
        435         


<210>  101
<211>  126
<212>  PRT
<213>  Homo sapiens

<400>  101

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Arg Val Ser Cys Lys Ala Ser Gly Phe Thr Phe Ile Ser Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Ala Gly Asp Gly His Thr Lys Tyr Ser Gln Lys Phe 
    50                  55                  60                  


Gln Asp Arg Val Ala Ile Thr Arg Asp Thr Ser Ala Thr Thr Val Tyr 
65                  70                  75                  80  


Met Asp Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Asp Gly Phe Cys Thr Thr Thr Thr Cys Ser Asp His Tyr Gly 
            100                 105                 110         


Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125     


<210>  102
<211>  389
<212>  PRT
<213>  Homo sapiens

<400>  102

Ala Thr Gly Gly Cys Cys Thr Gly Gly Gly Cys Thr Cys Thr Gly Cys 
1               5                   10                  15      


Thr Gly Cys Thr Cys Cys Thr Cys Ala Ala Cys Cys Thr Cys Cys Thr 
            20                  25                  30          


Cys Ala Cys Thr Cys Ala Gly Gly Ala Cys Ala Cys Ala Gly Gly Gly 
        35                  40                  45              


Thr Cys Cys Thr Gly Gly Gly Cys Cys Cys Ala Gly Thr Cys Thr Gly 
    50                  55                  60                  


Cys Cys Cys Thr Gly Ala Cys Thr Cys Ala Gly Cys Cys Thr Gly Cys 
65                  70                  75                  80  


Cys Thr Cys Cys Gly Thr Gly Thr Cys Thr Gly Gly Gly Thr Cys Thr 
                85                  90                  95      


Cys Cys Thr Gly Gly Ala Cys Ala Gly Thr Cys Gly Ala Thr Cys Ala 
            100                 105                 110         


Cys Cys Ala Thr Cys Thr Cys Cys Thr Gly Cys Ala Cys Thr Gly Gly 
        115                 120                 125             


Ala Ala Cys Cys Ala Gly Cys Ala Gly Thr Gly Ala Thr Gly Thr Thr 
    130                 135                 140                 


Gly Gly Thr Ala Gly Thr Thr Ala Thr Ala Ala Cys Thr Ala Thr Gly 
145                 150                 155                 160 


Thr Cys Thr Cys Cys Thr Gly Gly Thr Ala Cys Cys Ala Ala Cys Ala 
                165                 170                 175     


Gly Cys Ala Cys Cys Cys Ala Gly Gly Cys Ala Ala Ala Gly Cys Cys 
            180                 185                 190         


Cys Cys Cys Ala Ala Ala Thr Thr Cys Ala Thr Gly Ala Thr Thr Thr 
        195                 200                 205             


Ala Thr Gly Ala Thr Gly Thr Cys Ala Gly Thr Ala Ala Gly Cys Gly 
    210                 215                 220                 


Gly Cys Cys Cys Thr Cys Ala Gly Gly Gly Gly Thr Thr Thr Cys Thr 
225                 230                 235                 240 


Gly Ala Thr Cys Gly Cys Thr Thr Cys Thr Cys Thr Gly Gly Cys Thr 
                245                 250                 255     


Cys Cys Ala Ala Gly Thr Cys Thr Gly Gly Cys Ala Ala Cys Ala Cys 
            260                 265                 270         


Gly Gly Cys Cys Thr Cys Cys Cys Thr Gly Ala Cys Ala Ala Thr Cys 
        275                 280                 285             


Thr Cys Thr Gly Gly Gly Cys Thr Cys Cys Ala Gly Gly Cys Thr Gly 
    290                 295                 300                 


Ala Gly Gly Ala Cys Gly Ala Gly Gly Cys Thr Gly Ala Thr Thr Ala 
305                 310                 315                 320 


Thr Thr Ala Cys Thr Gly Cys Thr Gly Cys Thr Cys Ala Thr Ala Thr 
                325                 330                 335     


Gly Cys Ala Gly Gly Thr Ala Gly Thr Ala Gly Cys Ala Cys Thr Thr 
            340                 345                 350         


Gly Gly Gly Thr Gly Thr Thr Cys Gly Gly Cys Gly Gly Ala Gly Gly 
        355                 360                 365             


Gly Ala Cys Cys Ala Ala Gly Cys Thr Gly Ala Cys Cys Gly Thr Cys 
    370                 375                 380                 


Cys Thr Thr Gly Gly 
385                 


<210>  103
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  103

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Ser Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Phe 
        35                  40                  45              


Met Ile Tyr Asp Val Ser Lys Arg Pro Ser Gly Val Ser Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Cys Ser Tyr Ala Gly Ser 
                85                  90                  95      


Ser Thr Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  104
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  104

Gly Phe Thr Phe Thr Ser Tyr Ala Ile Gln 
1               5                   10  


<210>  105
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  105

Cys Ser Tyr Ala Gly Gly Ser Thr Trp Val 
1               5                   10  


<210>  106
<211>  437
<212>  PRT
<213>  Homo sapiens

<400>  106

Ala Thr Gly Gly Ala Cys Thr Gly Gly Ala Cys Cys Thr Gly Gly Ala 
1               5                   10                  15      


Gly Gly Ala Thr Cys Cys Thr Cys Thr Thr Thr Thr Thr Gly Gly Thr 
            20                  25                  30          


Gly Gly Cys Ala Gly Cys Ala Gly Cys Cys Ala Cys Ala Gly Gly Thr 
        35                  40                  45              


Gly Cys Cys Cys Ala Cys Thr Cys Cys Cys Ala Gly Gly Thr Cys Cys 
    50                  55                  60                  


Ala Gly Cys Thr Thr Gly Thr Gly Cys Ala Gly Thr Cys Thr Gly Gly 
65                  70                  75                  80  


Gly Gly Cys Thr Gly Ala Gly Gly Thr Gly Ala Ala Gly Ala Ala Gly 
                85                  90                  95      


Cys Cys Thr Gly Gly Gly Gly Cys Cys Thr Cys Ala Gly Thr Gly Ala 
            100                 105                 110         


Gly Gly Gly Thr Thr Thr Cys Cys Thr Gly Cys Ala Ala Gly Ala Cys 
        115                 120                 125             


Thr Thr Cys Thr Gly Gly Ala Thr Thr Cys Ala Cys Cys Thr Thr Cys 
    130                 135                 140                 


Ala Cys Thr Ala Gly Thr Thr Ala Thr Gly Cys Thr Ala Thr Ala Cys 
145                 150                 155                 160 


Ala Gly Thr Gly Gly Gly Thr Gly Cys Gly Cys Cys Ala Gly Gly Cys 
                165                 170                 175     


Cys Cys Cys Cys Gly Gly Ala Cys Ala Ala Gly Gly Gly Cys Thr Thr 
            180                 185                 190         


Gly Ala Gly Thr Gly Gly Ala Thr Gly Gly Gly Ala Thr Gly Gly Ala 
        195                 200                 205             


Thr Cys Ala Ala Cys Gly Cys Thr Gly Gly Cys Gly Ala Thr Gly Gly 
    210                 215                 220                 


Thr Cys Ala Cys Ala Cys Gly Ala Ala Ala Thr Ala Thr Thr Cys Ala 
225                 230                 235                 240 


Cys Ala Gly Ala Ala Gly Thr Thr Cys Cys Ala Gly Gly Ala Cys Ala 
                245                 250                 255     


Gly Ala Gly Thr Cys Gly Thr Cys Ala Thr Thr Ala Cys Cys Ala Gly 
            260                 265                 270         


Gly Gly Ala Cys Ala Cys Ala Thr Cys Cys Gly Cys Gly Ala Cys Cys 
        275                 280                 285             


Ala Cys Ala Gly Thr Cys Thr Ala Cys Ala Thr Gly Gly Ala Cys Cys 
    290                 295                 300                 


Thr Gly Ala Gly Cys Ala Gly Cys Cys Thr Gly Ala Gly Ala Thr Cys 
305                 310                 315                 320 


Thr Gly Ala Ala Gly Ala Cys Ala Cys Gly Gly Cys Thr Gly Thr Gly 
                325                 330                 335     


Thr Ala Thr Thr Ala Cys Thr Gly Thr Ala Cys Gly Ala Gly Ala Gly 
            340                 345                 350         


Ala Thr Gly Gly Ala Thr Thr Thr Thr Gly Thr Ala Cys Thr Ala Cys 
        355                 360                 365             


Gly Ala Cys Cys Ala Cys Cys Thr Gly Cys Thr Cys Cys Gly Ala Cys 
    370                 375                 380                 


Cys Ala Cys Thr Ala Cys Gly Gly Thr Ala Thr Gly Gly Ala Cys Gly 
385                 390                 395                 400 


Thr Cys Thr Gly Gly Gly Gly Cys Cys Ala Ala Gly Gly Gly Ala Cys 
                405                 410                 415     


Cys Ala Cys Gly Gly Thr Cys Ala Cys Cys Gly Thr Cys Thr Cys Cys 
            420                 425                 430         


Thr Cys Ala Gly Cys 
        435         


<210>  107
<211>  126
<212>  PRT
<213>  Homo sapiens

<400>  107

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Arg Val Ser Cys Lys Thr Ser Gly Phe Thr Phe Thr Ser Tyr 
            20                  25                  30          


Ala Ile Gln Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Ala Gly Asp Gly His Thr Lys Tyr Ser Gln Lys Phe 
    50                  55                  60                  


Gln Asp Arg Val Val Ile Thr Arg Asp Thr Ser Ala Thr Thr Val Tyr 
65                  70                  75                  80  


Met Asp Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Asp Gly Phe Cys Thr Thr Thr Thr Cys Ser Asp His Tyr Gly 
            100                 105                 110         


Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125     


<210>  108
<211>  389
<212>  PRT
<213>  Homo sapiens

<400>  108

Ala Thr Gly Gly Cys Cys Thr Gly Gly Gly Cys Thr Cys Thr Gly Cys 
1               5                   10                  15      


Thr Gly Cys Thr Cys Cys Thr Cys Ala Ala Cys Cys Thr Cys Cys Thr 
            20                  25                  30          


Cys Ala Cys Thr Cys Ala Gly Gly Ala Cys Ala Cys Ala Gly Gly Gly 
        35                  40                  45              


Thr Cys Cys Thr Gly Gly Gly Cys Cys Cys Ala Gly Thr Cys Thr Gly 
    50                  55                  60                  


Cys Cys Cys Thr Gly Ala Cys Thr Cys Ala Gly Cys Cys Thr Gly Cys 
65                  70                  75                  80  


Cys Thr Cys Cys Gly Thr Gly Thr Cys Thr Gly Gly Gly Thr Cys Thr 
                85                  90                  95      


Cys Cys Thr Gly Gly Ala Cys Ala Gly Thr Cys Gly Ala Thr Cys Ala 
            100                 105                 110         


Cys Cys Ala Thr Cys Thr Cys Cys Thr Gly Cys Ala Cys Thr Gly Gly 
        115                 120                 125             


Ala Ala Cys Cys Ala Gly Cys Ala Gly Thr Gly Ala Thr Gly Thr Thr 
    130                 135                 140                 


Gly Gly Thr Ala Gly Thr Thr Ala Thr Ala Ala Cys Thr Ala Thr Gly 
145                 150                 155                 160 


Thr Cys Thr Cys Cys Thr Gly Gly Thr Ala Cys Cys Ala Ala Cys Ala 
                165                 170                 175     


Gly Cys Ala Cys Cys Cys Ala Gly Gly Cys Ala Ala Ala Gly Thr Cys 
            180                 185                 190         


Cys Cys Cys Ala Ala Ala Thr Thr Cys Ala Thr Gly Ala Thr Thr Thr 
        195                 200                 205             


Cys Thr Gly Ala Thr Gly Thr Cys Ala Gly Thr Ala Ala Gly Cys Gly 
    210                 215                 220                 


Gly Cys Cys Cys Thr Cys Ala Gly Gly Ala Ala Thr Thr Thr Cys Thr 
225                 230                 235                 240 


Gly Ala Thr Cys Gly Cys Thr Thr Cys Thr Cys Thr Gly Gly Cys Thr 
                245                 250                 255     


Cys Cys Ala Ala Gly Thr Cys Thr Gly Gly Cys Ala Ala Thr Ala Cys 
            260                 265                 270         


Gly Gly Cys Cys Thr Cys Cys Cys Thr Gly Ala Cys Ala Ala Thr Cys 
        275                 280                 285             


Thr Cys Thr Gly Gly Gly Cys Thr Cys Cys Ala Gly Gly Cys Thr Gly 
    290                 295                 300                 


Ala Gly Gly Ala Cys Gly Ala Gly Gly Cys Thr Gly Ala Thr Thr Ala 
305                 310                 315                 320 


Thr Thr Ala Cys Thr Gly Cys Thr Gly Cys Thr Cys Ala Thr Ala Thr 
                325                 330                 335     


Gly Cys Ala Gly Gly Thr Gly Gly Thr Ala Gly Thr Ala Cys Thr Thr 
            340                 345                 350         


Gly Gly Gly Thr Gly Thr Thr Cys Gly Gly Cys Gly Gly Ala Gly Gly 
        355                 360                 365             


Gly Ala Cys Cys Ala Ala Gly Cys Thr Gly Ala Cys Cys Gly Thr Cys 
    370                 375                 380                 


Cys Thr Thr Gly Gly 
385                 


<210>  109
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  109

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Ser Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Val Pro Lys Phe 
        35                  40                  45              


Met Ile Ser Asp Val Ser Lys Arg Pro Ser Gly Ile Ser Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Cys Ser Tyr Ala Gly Gly 
                85                  90                  95      


Ser Thr Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  110
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  110

Gly Phe Thr Phe Thr Asn Tyr Ala Met His 
1               5                   10  


<210>  111
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  111

Asp Gly Phe Cys Ser Thr Thr Thr Cys Ser Asp His Tyr Gly Met Asp 
1               5                   10                  15      


Val 
    


<210>  112
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  112

Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr Asn Tyr Val Ser 
1               5                   10                  


<210>  113
<211>  437
<212>  PRT
<213>  Homo sapiens

<400>  113

Ala Thr Gly Gly Ala Cys Thr Gly Gly Ala Cys Cys Thr Gly Gly Ala 
1               5                   10                  15      


Gly Gly Ala Thr Cys Cys Thr Cys Thr Thr Thr Thr Thr Gly Gly Thr 
            20                  25                  30          


Gly Gly Cys Ala Gly Cys Ala Gly Cys Cys Ala Cys Ala Gly Gly Thr 
        35                  40                  45              


Gly Cys Cys Cys Ala Cys Thr Cys Cys Cys Ala Gly Gly Thr Cys Cys 
    50                  55                  60                  


Ala Gly Cys Thr Thr Gly Thr Gly Cys Ala Gly Thr Cys Thr Gly Gly 
65                  70                  75                  80  


Gly Gly Cys Thr Gly Ala Gly Gly Thr Gly Ala Ala Gly Ala Ala Cys 
                85                  90                  95      


Cys Cys Thr Gly Gly Gly Gly Cys Cys Thr Cys Ala Gly Thr Gly Ala 
            100                 105                 110         


Ala Gly Gly Thr Thr Thr Cys Cys Thr Gly Cys Ala Ala Gly Gly Cys 
        115                 120                 125             


Thr Thr Cys Thr Gly Gly Ala Thr Thr Cys Ala Cys Cys Thr Thr Cys 
    130                 135                 140                 


Ala Cys Thr Ala Ala Cys Thr Ala Thr Gly Cys Thr Ala Thr Gly Cys 
145                 150                 155                 160 


Ala Thr Thr Gly Gly Gly Thr Gly Cys Gly Cys Cys Ala Gly Gly Cys 
                165                 170                 175     


Cys Cys Cys Cys Gly Gly Ala Cys Ala Ala Ala Gly Gly Cys Thr Thr 
            180                 185                 190         


Gly Ala Gly Thr Gly Gly Ala Thr Gly Gly Gly Ala Thr Gly Gly Ala 
        195                 200                 205             


Thr Cys Ala Ala Cys Gly Cys Thr Gly Gly Cys Ala Ala Thr Gly Gly 
    210                 215                 220                 


Thr Cys Ala Cys Ala Cys Ala Ala Ala Ala Thr Ala Thr Thr Cys Ala 
225                 230                 235                 240 


Cys Ala Gly Ala Ala Gly Thr Thr Cys Cys Ala Gly Gly Ala Cys Ala 
                245                 250                 255     


Gly Ala Gly Thr Cys Gly Cys Cys Ala Thr Thr Ala Cys Cys Ala Gly 
            260                 265                 270         


Gly Gly Ala Cys Ala Cys Ala Thr Cys Cys Gly Cys Gly Ala Cys Cys 
        275                 280                 285             


Ala Cys Ala Gly Cys Cys Thr Ala Cys Ala Thr Gly Gly Ala Ala Cys 
    290                 295                 300                 


Thr Gly Ala Gly Cys Ala Gly Cys Cys Thr Gly Ala Gly Ala Thr Cys 
305                 310                 315                 320 


Thr Gly Ala Ala Gly Ala Cys Ala Cys Gly Gly Cys Thr Gly Thr Gly 
                325                 330                 335     


Thr Ala Thr Thr Ala Cys Thr Gly Thr Thr Cys Gly Ala Gly Ala Gly 
            340                 345                 350         


Ala Thr Gly Gly Ala Thr Thr Thr Thr Gly Thr Ala Gly Thr Ala Cys 
        355                 360                 365             


Thr Ala Cys Cys Ala Cys Cys Thr Gly Cys Thr Cys Cys Gly Ala Cys 
    370                 375                 380                 


Cys Ala Cys Thr Ala Cys Gly Gly Thr Ala Thr Gly Gly Ala Cys Gly 
385                 390                 395                 400 


Thr Cys Thr Gly Gly Gly Gly Cys Cys Ala Ala Gly Gly Gly Ala Cys 
                405                 410                 415     


Cys Ala Cys Gly Gly Thr Cys Ala Cys Cys Gly Thr Cys Thr Cys Cys 
            420                 425                 430         


Thr Cys Ala Gly Cys 
        435         


<210>  114
<211>  126
<212>  PRT
<213>  Homo sapiens

<400>  114

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Asn Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Thr Phe Thr Asn Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Ala Gly Asn Gly His Thr Lys Tyr Ser Gln Lys Phe 
    50                  55                  60                  


Gln Asp Arg Val Ala Ile Thr Arg Asp Thr Ser Ala Thr Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Asp Gly Phe Cys Ser Thr Thr Thr Cys Ser Asp His Tyr Gly 
            100                 105                 110         


Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125     


<210>  115
<211>  389
<212>  PRT
<213>  Homo sapiens

<400>  115

Ala Thr Gly Gly Cys Cys Thr Gly Gly Gly Cys Thr Cys Thr Gly Cys 
1               5                   10                  15      


Thr Gly Cys Thr Cys Cys Thr Cys Ala Ala Cys Cys Thr Cys Cys Thr 
            20                  25                  30          


Cys Ala Cys Thr Cys Ala Gly Gly Ala Cys Ala Cys Ala Gly Gly Gly 
        35                  40                  45              


Thr Cys Cys Thr Gly Gly Gly Cys Cys Cys Ala Gly Thr Cys Thr Gly 
    50                  55                  60                  


Cys Cys Cys Thr Gly Ala Cys Thr Cys Ala Gly Cys Cys Thr Gly Cys 
65                  70                  75                  80  


Cys Thr Cys Cys Gly Thr Gly Thr Cys Thr Gly Gly Gly Thr Cys Thr 
                85                  90                  95      


Cys Cys Thr Gly Gly Ala Cys Ala Gly Thr Cys Gly Ala Thr Cys Ala 
            100                 105                 110         


Cys Cys Ala Thr Cys Thr Cys Cys Thr Gly Cys Ala Cys Thr Gly Gly 
        115                 120                 125             


Ala Ala Cys Cys Ala Gly Cys Ala Gly Thr Gly Ala Thr Gly Thr Thr 
    130                 135                 140                 


Gly Gly Thr Gly Gly Thr Thr Ala Thr Ala Ala Cys Thr Ala Thr Gly 
145                 150                 155                 160 


Thr Cys Thr Cys Cys Thr Gly Gly Thr Ala Cys Cys Ala Ala Cys Ala 
                165                 170                 175     


Gly Cys Ala Cys Cys Cys Ala Gly Gly Cys Ala Ala Ala Gly Cys Cys 
            180                 185                 190         


Cys Cys Cys Ala Ala Ala Thr Thr Cys Ala Thr Gly Ala Thr Thr Thr 
        195                 200                 205             


Ala Thr Gly Ala Thr Gly Thr Cys Ala Gly Thr Ala Ala Gly Cys Gly 
    210                 215                 220                 


Gly Cys Cys Cys Thr Cys Ala Gly Gly Gly Gly Thr Thr Thr Cys Cys 
225                 230                 235                 240 


Ala Ala Thr Cys Gly Cys Thr Thr Cys Thr Cys Thr Gly Gly Cys Thr 
                245                 250                 255     


Cys Cys Ala Ala Gly Thr Cys Thr Gly Gly Cys Ala Ala Cys Ala Cys 
            260                 265                 270         


Gly Gly Cys Cys Thr Cys Cys Cys Thr Gly Ala Cys Ala Ala Thr Cys 
        275                 280                 285             


Thr Cys Thr Gly Gly Gly Cys Thr Cys Cys Ala Gly Gly Cys Thr Gly 
    290                 295                 300                 


Ala Gly Gly Ala Cys Gly Ala Gly Gly Cys Thr Gly Ala Thr Thr Ala 
305                 310                 315                 320 


Thr Thr Ala Cys Thr Gly Cys Thr Gly Cys Thr Cys Ala Thr Ala Thr 
                325                 330                 335     


Gly Cys Ala Gly Gly Thr Ala Gly Thr Ala Gly Cys Ala Cys Thr Thr 
            340                 345                 350         


Gly Gly Gly Thr Gly Thr Thr Cys Gly Gly Cys Gly Gly Ala Gly Gly 
        355                 360                 365             


Gly Ala Cys Cys Ala Ala Gly Cys Thr Gly Ala Cys Cys Gly Thr Cys 
    370                 375                 380                 


Cys Thr Ala Gly Gly 
385                 


<210>  116
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  116

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Phe 
        35                  40                  45              


Met Ile Tyr Asp Val Ser Lys Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Cys Ser Tyr Ala Gly Ser 
                85                  90                  95      


Ser Thr Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  117
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  117

Gly Phe Thr Phe Thr Ser His Ala Ile His 
1               5                   10  


<210>  118
<211>  437
<212>  PRT
<213>  Homo sapiens

<400>  118

Ala Thr Gly Gly Ala Cys Thr Gly Gly Ala Cys Cys Thr Gly Gly Ala 
1               5                   10                  15      


Gly Gly Ala Thr Cys Cys Thr Cys Thr Thr Thr Thr Thr Gly Gly Thr 
            20                  25                  30          


Gly Gly Cys Ala Gly Cys Ala Gly Cys Cys Ala Cys Ala Gly Gly Thr 
        35                  40                  45              


Gly Cys Cys Cys Ala Cys Thr Cys Cys Cys Ala Gly Gly Thr Cys Cys 
    50                  55                  60                  


Ala Gly Cys Thr Thr Gly Thr Gly Cys Ala Gly Thr Cys Thr Gly Gly 
65                  70                  75                  80  


Gly Gly Cys Thr Gly Ala Gly Gly Thr Gly Ala Ala Gly Ala Ala Gly 
                85                  90                  95      


Cys Cys Thr Gly Gly Gly Gly Cys Cys Thr Cys Ala Gly Thr Gly Ala 
            100                 105                 110         


Ala Gly Gly Thr Thr Thr Cys Cys Thr Gly Cys Ala Ala Gly Gly Cys 
        115                 120                 125             


Thr Thr Cys Thr Gly Gly Ala Thr Thr Cys Ala Cys Cys Thr Thr Cys 
    130                 135                 140                 


Ala Cys Thr Ala Gly Cys Cys Ala Thr Gly Cys Thr Ala Thr Ala Cys 
145                 150                 155                 160 


Ala Thr Thr Gly Gly Gly Thr Gly Cys Gly Cys Cys Ala Gly Gly Cys 
                165                 170                 175     


Cys Cys Cys Cys Gly Gly Ala Cys Ala Ala Ala Gly Gly Cys Thr Thr 
            180                 185                 190         


Gly Ala Gly Thr Gly Gly Ala Thr Gly Gly Gly Ala Thr Gly Gly Ala 
        195                 200                 205             


Thr Cys Ala Ala Cys Gly Cys Thr Gly Gly Cys Ala Ala Thr Gly Gly 
    210                 215                 220                 


Thr Thr Ala Cys Ala Cys Ala Ala Ala Ala Thr Ala Thr Thr Cys Ala 
225                 230                 235                 240 


Cys Ala Gly Ala Ala Gly Thr Thr Cys Cys Ala Gly Gly Ala Cys Ala 
                245                 250                 255     


Gly Ala Gly Thr Cys Gly Cys Cys Ala Thr Thr Ala Cys Cys Ala Gly 
            260                 265                 270         


Gly Gly Ala Cys Ala Cys Ala Thr Cys Cys Gly Cys Gly Ala Gly Cys 
        275                 280                 285             


Ala Cys Ala Gly Cys Cys Thr Ala Cys Ala Thr Gly Gly Ala Gly Cys 
    290                 295                 300                 


Thr Gly Ala Gly Cys Ala Gly Cys Cys Thr Gly Ala Gly Ala Thr Cys 
305                 310                 315                 320 


Thr Gly Ala Ala Gly Ala Cys Ala Cys Gly Gly Cys Thr Gly Thr Gly 
                325                 330                 335     


Thr Ala Thr Thr Ala Cys Thr Gly Thr Ala Cys Gly Ala Gly Ala Gly 
            340                 345                 350         


Ala Thr Gly Gly Ala Thr Thr Thr Thr Gly Thr Ala Gly Thr Ala Cys 
        355                 360                 365             


Thr Ala Cys Cys Ala Cys Cys Thr Gly Cys Thr Cys Cys Gly Ala Cys 
    370                 375                 380                 


Cys Ala Cys Thr Ala Cys Gly Gly Thr Ala Thr Gly Gly Ala Cys Gly 
385                 390                 395                 400 


Thr Cys Thr Gly Gly Gly Gly Cys Cys Ala Ala Gly Gly Gly Ala Cys 
                405                 410                 415     


Cys Ala Cys Gly Gly Thr Cys Ala Cys Cys Gly Thr Cys Thr Cys Cys 
            420                 425                 430         


Thr Cys Ala Gly Cys 
        435         


<210>  119
<211>  126
<212>  PRT
<213>  Homo sapiens

<400>  119

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Thr Phe Thr Ser His 
            20                  25                  30          


Ala Ile His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Ala Gly Asn Gly Tyr Thr Lys Tyr Ser Gln Lys Phe 
    50                  55                  60                  


Gln Asp Arg Val Ala Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Asp Gly Phe Cys Ser Thr Thr Thr Cys Ser Asp His Tyr Gly 
            100                 105                 110         


Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125     


<210>  120
<211>  389
<212>  PRT
<213>  Homo sapiens

<400>  120

Ala Thr Gly Gly Cys Cys Thr Gly Gly Gly Cys Thr Cys Thr Gly Cys 
1               5                   10                  15      


Thr Gly Cys Thr Cys Cys Thr Cys Ala Ala Cys Cys Thr Cys Cys Thr 
            20                  25                  30          


Cys Ala Cys Thr Cys Ala Gly Gly Ala Cys Ala Cys Ala Gly Gly Gly 
        35                  40                  45              


Thr Cys Cys Thr Gly Gly Gly Cys Cys Cys Ala Gly Thr Cys Thr Gly 
    50                  55                  60                  


Cys Cys Cys Thr Gly Ala Cys Thr Cys Ala Gly Cys Cys Thr Gly Cys 
65                  70                  75                  80  


Cys Thr Cys Cys Gly Thr Gly Thr Cys Thr Gly Gly Gly Thr Cys Thr 
                85                  90                  95      


Cys Cys Thr Gly Gly Ala Cys Ala Gly Thr Cys Gly Ala Thr Cys Ala 
            100                 105                 110         


Cys Cys Ala Thr Cys Thr Cys Cys Thr Gly Cys Ala Cys Thr Gly Gly 
        115                 120                 125             


Ala Ala Cys Cys Ala Gly Cys Ala Gly Thr Gly Ala Thr Gly Thr Thr 
    130                 135                 140                 


Gly Gly Cys Gly Gly Thr Thr Ala Thr Ala Ala Cys Thr Ala Thr Gly 
145                 150                 155                 160 


Thr Cys Thr Cys Cys Thr Gly Gly Thr Ala Cys Cys Ala Ala Cys Ala 
                165                 170                 175     


Gly Cys Ala Cys Cys Cys Ala Gly Gly Cys Ala Ala Ala Gly Cys Cys 
            180                 185                 190         


Cys Cys Cys Ala Ala Ala Thr Thr Cys Ala Thr Gly Ala Thr Thr Thr 
        195                 200                 205             


Ala Thr Gly Ala Thr Gly Thr Cys Ala Gly Thr Ala Ala Gly Cys Gly 
    210                 215                 220                 


Gly Cys Cys Cys Thr Cys Ala Gly Gly Gly Gly Thr Thr Thr Cys Thr 
225                 230                 235                 240 


Ala Ala Thr Cys Gly Cys Thr Thr Cys Thr Cys Thr Gly Gly Cys Thr 
                245                 250                 255     


Cys Cys Ala Ala Gly Thr Cys Thr Gly Gly Cys Ala Ala Cys Ala Cys 
            260                 265                 270         


Gly Gly Cys Cys Thr Cys Cys Cys Thr Gly Ala Cys Ala Ala Thr Cys 
        275                 280                 285             


Thr Cys Thr Gly Gly Gly Cys Thr Cys Cys Ala Gly Gly Cys Thr Gly 
    290                 295                 300                 


Ala Gly Gly Ala Cys Gly Ala Gly Gly Cys Thr Gly Ala Thr Thr Ala 
305                 310                 315                 320 


Thr Thr Ala Cys Thr Gly Cys Thr Gly Cys Thr Cys Ala Thr Ala Thr 
                325                 330                 335     


Gly Cys Ala Gly Gly Thr Ala Gly Thr Ala Gly Cys Ala Cys Thr Thr 
            340                 345                 350         


Gly Gly Gly Thr Gly Thr Thr Cys Gly Gly Cys Gly Gly Ala Gly Gly 
        355                 360                 365             


Gly Ala Cys Cys Ala Ala Gly Cys Thr Gly Ala Cys Cys Gly Thr Cys 
    370                 375                 380                 


Cys Thr Ala Gly Gly 
385                 


<210>  121
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  121

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Phe 
        35                  40                  45              


Met Ile Tyr Asp Val Ser Lys Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Cys Ser Tyr Ala Gly Ser 
                85                  90                  95      


Ser Thr Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  122
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  122

Gly Tyr Ile Phe Ile Asn Tyr Ala Met Gln 
1               5                   10  


<210>  123
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  123

Asp Gly Phe Cys Arg Thr Thr Ser Cys Ser Asp His Tyr Gly Met Asp 
1               5                   10                  15      


Val 
    


<210>  124
<211>  437
<212>  PRT
<213>  Homo sapiens

<400>  124

Ala Thr Gly Gly Ala Cys Thr Gly Gly Ala Cys Cys Thr Gly Gly Ala 
1               5                   10                  15      


Gly Gly Ala Thr Cys Cys Thr Cys Thr Thr Thr Thr Thr Gly Gly Thr 
            20                  25                  30          


Gly Gly Cys Ala Gly Cys Ala Gly Cys Cys Ala Cys Ala Gly Gly Thr 
        35                  40                  45              


Gly Cys Cys Cys Ala Cys Thr Cys Cys Cys Ala Gly Gly Thr Cys Cys 
    50                  55                  60                  


Ala Gly Cys Thr Thr Gly Thr Gly Cys Ala Gly Thr Cys Thr Gly Gly 
65                  70                  75                  80  


Gly Gly Cys Thr Gly Ala Gly Gly Thr Gly Ala Ala Gly Ala Ala Gly 
                85                  90                  95      


Cys Cys Thr Gly Gly Gly Gly Cys Cys Thr Cys Ala Gly Thr Gly Ala 
            100                 105                 110         


Ala Gly Gly Thr Thr Thr Cys Cys Thr Gly Thr Ala Ala Gly Gly Cys 
        115                 120                 125             


Thr Thr Cys Thr Gly Gly Ala Thr Ala Cys Ala Thr Cys Thr Thr Thr 
    130                 135                 140                 


Ala Thr Thr Ala Ala Cys Thr Ala Thr Gly Cys Thr Ala Thr Gly Cys 
145                 150                 155                 160 


Ala Ala Thr Gly Gly Gly Thr Gly Cys Gly Cys Cys Ala Gly Gly Cys 
                165                 170                 175     


Cys Cys Cys Cys Gly Gly Ala Cys Ala Ala Ala Gly Gly Cys Thr Thr 
            180                 185                 190         


Gly Ala Gly Thr Gly Gly Ala Thr Gly Gly Gly Ala Thr Gly Gly Ala 
        195                 200                 205             


Thr Cys Ala Ala Cys Gly Cys Thr Gly Gly Cys Ala Ala Cys Gly Gly 
    210                 215                 220                 


Thr Thr Ala Cys Ala Cys Ala Ala Ala Ala Thr Ala Thr Thr Cys Ala 
225                 230                 235                 240 


Cys Ala Gly Ala Ala Gly Thr Thr Cys Cys Ala Gly Gly Gly Cys Ala 
                245                 250                 255     


Gly Ala Gly Thr Cys Ala Cys Cys Ala Thr Cys Ala Cys Cys Ala Gly 
            260                 265                 270         


Gly Gly Ala Cys Ala Thr Ala Thr Cys Cys Gly Cys Gly Ala Gly Cys 
        275                 280                 285             


Ala Cys Ala Gly Thr Cys Thr Ala Cys Ala Thr Gly Gly Ala Gly Cys 
    290                 295                 300                 


Thr Gly Ala Gly Cys Ala Gly Cys Cys Thr Gly Ala Gly Ala Thr Cys 
305                 310                 315                 320 


Thr Gly Ala Ala Gly Ala Cys Ala Cys Gly Gly Cys Thr Gly Thr Gly 
                325                 330                 335     


Thr Ala Thr Thr Ala Cys Thr Gly Thr Gly Cys Gly Ala Gly Ala Gly 
            340                 345                 350         


Ala Thr Gly Gly Ala Thr Thr Thr Thr Gly Thr Ala Gly Gly Ala Cys 
        355                 360                 365             


Ala Ala Cys Cys Ala Gly Cys Thr Gly Cys Thr Cys Cys Gly Ala Cys 
    370                 375                 380                 


Cys Ala Cys Thr Ala Cys Gly Gly Thr Ala Thr Gly Gly Ala Cys Gly 
385                 390                 395                 400 


Thr Cys Thr Gly Gly Gly Gly Cys Cys Ala Ala Gly Gly Gly Ala Cys 
                405                 410                 415     


Cys Ala Cys Gly Gly Thr Cys Ala Cys Cys Gly Thr Cys Thr Cys Cys 
            420                 425                 430         


Thr Cys Ala Gly Cys 
        435         


<210>  125
<211>  126
<212>  PRT
<213>  Homo sapiens

<400>  125

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ile Phe Ile Asn Tyr 
            20                  25                  30          


Ala Met Gln Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Ala Gly Asn Gly Tyr Thr Lys Tyr Ser Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Ile Ser Ala Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Phe Cys Arg Thr Thr Ser Cys Ser Asp His Tyr Gly 
            100                 105                 110         


Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125     


<210>  126
<211>  389
<212>  PRT
<213>  Homo sapiens

<400>  126

Ala Thr Gly Gly Cys Cys Thr Gly Gly Gly Cys Thr Cys Thr Gly Cys 
1               5                   10                  15      


Thr Gly Cys Thr Cys Cys Thr Cys Ala Ala Cys Cys Thr Cys Cys Thr 
            20                  25                  30          


Cys Ala Cys Thr Cys Ala Gly Gly Ala Cys Ala Cys Ala Gly Gly Gly 
        35                  40                  45              


Thr Cys Cys Thr Gly Gly Gly Cys Cys Cys Ala Gly Thr Cys Thr Gly 
    50                  55                  60                  


Cys Cys Cys Thr Gly Ala Cys Thr Cys Ala Gly Cys Cys Thr Gly Cys 
65                  70                  75                  80  


Cys Thr Cys Cys Gly Thr Gly Thr Cys Thr Gly Gly Gly Thr Cys Thr 
                85                  90                  95      


Cys Cys Thr Gly Gly Ala Cys Ala Gly Thr Cys Gly Ala Thr Cys Ala 
            100                 105                 110         


Cys Cys Ala Thr Cys Thr Cys Cys Thr Gly Cys Ala Cys Thr Gly Gly 
        115                 120                 125             


Ala Ala Cys Cys Ala Gly Cys Ala Gly Thr Gly Ala Thr Gly Thr Thr 
    130                 135                 140                 


Gly Gly Thr Gly Gly Thr Thr Ala Thr Ala Ala Cys Thr Ala Thr Gly 
145                 150                 155                 160 


Thr Cys Thr Cys Cys Thr Gly Gly Thr Ala Cys Cys Ala Ala Cys Ala 
                165                 170                 175     


Ala Cys Ala Cys Cys Cys Ala Gly Gly Cys Ala Ala Ala Gly Cys Cys 
            180                 185                 190         


Cys Cys Cys Ala Ala Ala Cys Thr Cys Ala Thr Gly Ala Thr Thr Thr 
        195                 200                 205             


Ala Thr Gly Ala Thr Gly Thr Cys Ala Gly Thr Ala Ala Gly Cys Gly 
    210                 215                 220                 


Gly Cys Cys Cys Thr Cys Ala Gly Gly Gly Gly Thr Thr Thr Cys Thr 
225                 230                 235                 240 


Gly Ala Thr Cys Gly Cys Thr Thr Cys Thr Cys Thr Gly Gly Cys Thr 
                245                 250                 255     


Cys Cys Ala Ala Gly Thr Cys Thr Gly Gly Cys Ala Ala Cys Ala Cys 
            260                 265                 270         


Gly Gly Cys Cys Thr Cys Cys Cys Thr Gly Ala Cys Ala Ala Thr Cys 
        275                 280                 285             


Thr Cys Thr Gly Gly Gly Cys Thr Cys Cys Ala Gly Ala Cys Thr Gly 
    290                 295                 300                 


Ala Gly Gly Ala Cys Gly Ala Gly Gly Cys Thr Gly Ala Thr Thr Thr 
305                 310                 315                 320 


Thr Thr Ala Cys Thr Gly Cys Thr Gly Cys Thr Cys Ala Thr Ala Thr 
                325                 330                 335     


Gly Cys Ala Gly Gly Thr Ala Gly Thr Ala Gly Cys Ala Cys Thr Thr 
            340                 345                 350         


Gly Gly Gly Thr Gly Thr Thr Cys Gly Gly Cys Gly Gly Ala Gly Gly 
        355                 360                 365             


Gly Ala Cys Cys Ala Ala Gly Cys Thr Gly Ala Cys Cys Gly Thr Cys 
    370                 375                 380                 


Cys Thr Ala Gly Gly 
385                 


<210>  127
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  127

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Asp Val Ser Lys Arg Pro Ser Gly Val Ser Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Thr Glu Asp Glu Ala Asp Phe Tyr Cys Cys Ser Tyr Ala Gly Ser 
                85                  90                  95      


Ser Thr Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  128
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  128

Gly Phe Ile Phe Ile Asn Tyr Ala Met Gln 
1               5                   10  


<210>  129
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  129

Asp Gly Phe Cys Ser Thr Thr Thr Cys Ser Asp His Tyr Gly Met Asp 
1               5                   10                  15      


Val 
    


<210>  130
<211>  437
<212>  PRT
<213>  Homo sapiens

<400>  130

Ala Thr Gly Gly Ala Cys Thr Gly Gly Ala Cys Cys Thr Gly Gly Ala 
1               5                   10                  15      


Gly Gly Ala Thr Cys Cys Thr Cys Thr Thr Thr Thr Thr Gly Gly Thr 
            20                  25                  30          


Gly Gly Cys Ala Gly Cys Ala Gly Cys Cys Ala Cys Ala Gly Gly Thr 
        35                  40                  45              


Gly Thr Cys Cys Ala Cys Thr Cys Cys Cys Ala Gly Gly Thr Cys Cys 
    50                  55                  60                  


Ala Gly Cys Thr Thr Gly Thr Gly Cys Ala Gly Thr Cys Thr Gly Gly 
65                  70                  75                  80  


Gly Gly Cys Thr Gly Ala Gly Gly Thr Gly Ala Ala Gly Ala Ala Gly 
                85                  90                  95      


Cys Cys Thr Gly Gly Gly Gly Cys Cys Thr Cys Ala Gly Thr Gly Ala 
            100                 105                 110         


Ala Gly Gly Thr Thr Thr Cys Cys Thr Gly Cys Ala Ala Gly Gly Cys 
        115                 120                 125             


Thr Thr Cys Thr Gly Gly Ala Thr Thr Cys Ala Thr Cys Thr Thr Thr 
    130                 135                 140                 


Ala Thr Thr Ala Ala Cys Thr Ala Thr Gly Cys Thr Ala Thr Gly Cys 
145                 150                 155                 160 


Ala Ala Thr Gly Gly Gly Thr Gly Cys Gly Cys Cys Ala Gly Gly Cys 
                165                 170                 175     


Cys Cys Cys Cys Gly Gly Ala Cys Ala Ala Ala Gly Gly Cys Thr Thr 
            180                 185                 190         


Gly Ala Gly Thr Gly Gly Ala Thr Gly Gly Gly Ala Thr Gly Gly Ala 
        195                 200                 205             


Thr Cys Ala Ala Cys Gly Cys Thr Gly Gly Cys Ala Ala Cys Gly Gly 
    210                 215                 220                 


Thr Thr Ala Cys Ala Cys Ala Ala Ala Ala Thr Ala Thr Thr Cys Ala 
225                 230                 235                 240 


Cys Ala Gly Ala Ala Ala Thr Thr Cys Cys Ala Gly Gly Gly Cys Ala 
                245                 250                 255     


Gly Ala Gly Thr Cys Ala Cys Cys Ala Thr Cys Ala Cys Cys Ala Gly 
            260                 265                 270         


Gly Gly Ala Cys Ala Thr Ala Thr Cys Cys Gly Cys Gly Ala Ala Cys 
        275                 280                 285             


Ala Cys Ala Gly Thr Cys Thr Ala Cys Ala Thr Gly Gly Ala Gly Cys 
    290                 295                 300                 


Thr Gly Ala Gly Cys Ala Gly Cys Cys Thr Gly Ala Gly Ala Thr Cys 
305                 310                 315                 320 


Thr Gly Ala Ala Gly Ala Cys Ala Cys Gly Gly Cys Thr Gly Thr Gly 
                325                 330                 335     


Thr Ala Thr Thr Ala Cys Thr Gly Thr Gly Cys Gly Ala Gly Ala Gly 
            340                 345                 350         


Ala Thr Gly Gly Ala Thr Thr Thr Thr Gly Thr Ala Gly Thr Ala Cys 
        355                 360                 365             


Ala Ala Cys Cys Ala Cys Cys Thr Gly Cys Thr Cys Cys Gly Ala Cys 
    370                 375                 380                 


Cys Ala Cys Thr Ala Cys Gly Gly Thr Ala Thr Gly Gly Ala Cys Gly 
385                 390                 395                 400 


Thr Cys Thr Gly Gly Gly Gly Cys Cys Ala Ala Gly Gly Gly Ala Cys 
                405                 410                 415     


Cys Ala Cys Gly Gly Thr Cys Ala Cys Cys Gly Thr Cys Thr Cys Cys 
            420                 425                 430         


Thr Cys Ala Gly Cys 
        435         


<210>  131
<211>  126
<212>  PRT
<213>  Homo sapiens

<400>  131

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Ile Phe Ile Asn Tyr 
            20                  25                  30          


Ala Met Gln Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Ala Gly Asn Gly Tyr Thr Lys Tyr Ser Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Ile Ser Ala Asn Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Phe Cys Ser Thr Thr Thr Cys Ser Asp His Tyr Gly 
            100                 105                 110         


Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125     


<210>  132
<211>  389
<212>  PRT
<213>  Homo sapiens

<400>  132

Ala Thr Gly Gly Cys Cys Thr Gly Gly Gly Cys Thr Cys Thr Gly Cys 
1               5                   10                  15      


Thr Gly Cys Thr Cys Cys Thr Cys Ala Ala Cys Cys Thr Cys Cys Thr 
            20                  25                  30          


Cys Ala Cys Thr Cys Ala Gly Gly Ala Cys Ala Cys Ala Gly Gly Gly 
        35                  40                  45              


Thr Cys Cys Thr Gly Gly Gly Cys Cys Cys Ala Gly Thr Cys Thr Gly 
    50                  55                  60                  


Cys Cys Cys Thr Gly Ala Cys Thr Cys Ala Gly Cys Cys Thr Gly Cys 
65                  70                  75                  80  


Cys Thr Cys Cys Gly Thr Gly Thr Cys Thr Gly Gly Gly Thr Cys Thr 
                85                  90                  95      


Cys Cys Thr Gly Gly Ala Cys Ala Gly Thr Cys Gly Ala Thr Cys Ala 
            100                 105                 110         


Cys Cys Ala Thr Cys Thr Cys Cys Thr Gly Cys Ala Cys Thr Gly Gly 
        115                 120                 125             


Ala Ala Cys Cys Ala Gly Cys Ala Gly Thr Gly Ala Thr Gly Thr Thr 
    130                 135                 140                 


Gly Gly Thr Gly Gly Thr Thr Ala Thr Ala Ala Cys Thr Ala Thr Gly 
145                 150                 155                 160 


Thr Cys Thr Cys Cys Thr Gly Gly Thr Ala Cys Cys Ala Ala Cys Ala 
                165                 170                 175     


Ala Cys Ala Cys Cys Cys Ala Gly Gly Cys Ala Ala Ala Gly Cys Cys 
            180                 185                 190         


Cys Cys Cys Ala Ala Ala Cys Thr Cys Ala Thr Gly Ala Thr Thr Thr 
        195                 200                 205             


Ala Thr Gly Ala Thr Gly Thr Cys Ala Gly Thr Ala Ala Gly Cys Gly 
    210                 215                 220                 


Gly Cys Cys Cys Thr Cys Ala Gly Gly Gly Gly Thr Thr Thr Cys Thr 
225                 230                 235                 240 


Gly Ala Thr Cys Gly Cys Thr Thr Cys Thr Cys Thr Gly Gly Cys Thr 
                245                 250                 255     


Cys Cys Ala Ala Gly Thr Cys Thr Gly Gly Cys Ala Ala Cys Ala Cys 
            260                 265                 270         


Gly Gly Cys Cys Thr Cys Cys Cys Thr Gly Ala Cys Ala Ala Thr Cys 
        275                 280                 285             


Thr Cys Thr Gly Gly Gly Cys Thr Cys Cys Ala Gly Ala Cys Thr Gly 
    290                 295                 300                 


Ala Gly Gly Ala Cys Gly Ala Gly Gly Cys Thr Gly Ala Thr Thr Ala 
305                 310                 315                 320 


Thr Thr Ala Cys Thr Gly Cys Thr Gly Cys Thr Cys Ala Thr Ala Thr 
                325                 330                 335     


Gly Cys Ala Gly Gly Thr Ala Gly Thr Ala Gly Cys Ala Cys Thr Thr 
            340                 345                 350         


Gly Gly Gly Thr Gly Thr Thr Cys Gly Gly Cys Gly Gly Ala Gly Gly 
        355                 360                 365             


Gly Ala Cys Cys Ala Ala Gly Cys Thr Gly Ala Cys Cys Gly Thr Cys 
    370                 375                 380                 


Cys Thr Ala Gly Gly 
385                 


<210>  133
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  133

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Asp Val Ser Lys Arg Pro Ser Gly Val Ser Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Cys Ser Tyr Ala Gly Ser 
                85                  90                  95      


Ser Thr Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  134
<211>  10
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is Tyr or Phe

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is Asn or Asp

<400>  134

Gly Xaa Thr Phe Thr Xaa Tyr Ala Met His 
1               5                   10  


<210>  135
<211>  13
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is Asn or Ser

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa is Ile or Ser

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa is His or Tyr-Val

<400>  135

Thr Gly Thr Ser Xaa Asp Val Gly Xaa Tyr Asn Xaa Ser 
1               5                   10              


<210>  136
<211>  7
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is Thr or Lys

<400>  136

Asp Val Asn Xaa Arg Pro Ser 
1               5           


<210>  137
<211>  10
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is Cys or Ser

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa is Ala or Thr

<400>  137

Xaa Ser Tyr Ala Gly Ser Ser Xaa Trp Val 
1               5                   10  


<210>  138
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  138

Asn Ala Gly Asn Gly Tyr 
1               5       


<210>  139
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  139

Gly Tyr Thr Phe Ser Asn Tyr 
1               5           


<210>  140
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  140

Gly Phe Thr Phe Thr Asp Tyr 
1               5           


<210>  141
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  141

Gly Phe Thr Phe Thr Ser Tyr 
1               5           


<210>  142
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  142

Asn Ala Gly Asn Gly His 
1               5       


<210>  143
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  143

Gly Phe Thr Phe Ile Ser Tyr 
1               5           


<210>  144
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  144

Asn Ala Gly Asp Gly His 
1               5       


<210>  145
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  145

Ser Tyr Ala Ile Gln 
1               5   


<210>  146
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  146

Gly Phe Thr Phe Thr Asn Tyr 
1               5           


<210>  147
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  147

Ser His Ala Ile His 
1               5   


<210>  148
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  148

Gly Phe Thr Phe Thr Ser His 
1               5           


<210>  149
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  149

Asn Tyr Ala Met Gln 
1               5   


<210>  150
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  150

Gly Tyr Ile Phe Ile Asn Tyr 
1               5           


<210>  151
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  151

Gly Phe Ile Phe Ile Asn Tyr 
1               5           


<210>  152
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  152

Asp Asn Phe Phe Glu Ser Ser Gly Tyr Tyr Ser Tyr Tyr Phe Tyr Gly 
1               5                   10                  15      


Met Asp Val 
            


<210>  153
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  153

Trp Ile Asn Ala Gly Asn Gly Tyr Thr Lys Tyr Ser Gln Arg Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  154
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  154

Cys Ser Tyr Val Gly Ser Ser Thr Trp Ile 
1               5                   10  


<210>  155
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  155

Asp Asn Phe Tyr Gly Ser Gly Thr Tyr Phe Ser Tyr Phe Phe Tyr His 
1               5                   10                  15      


Met Asp Val 
            


<210>  156
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  156

Gly Tyr Thr Phe Thr Asn Tyr Ala Ile His 
1               5                   10  


<210>  157
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  157

Val Val Ser Lys Arg Pro Ser 
1               5           


<210>  158
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  158

Asp Gly Phe Cys Pro Ser Thr Thr Cys Ser Gly Tyr Tyr Gly Met Asp 
1               5                   10                  15      


Val 
    


<210>  159
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  159

Trp Ile Asn Ala Gly Asn Gly Tyr Thr Lys Tyr Ser Gln Lys Phe Gln 
1               5                   10                  15      


Val 
    


<210>  160
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  160

Ser Ser Tyr Ala Gly Ser Ser Thr Trp Ile 
1               5                   10  


<210>  161
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  161

Thr Gly Thr Ser Ser Asp Val Gly Ala Tyr Asn Tyr Val Ser 
1               5                   10                  


<210>  162
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  162

Trp Ile Asn Ala Gly Asn Gly Tyr Thr Lys Tyr Ser Gln Gln Phe Gln 
1               5                   10                  15      


Val 
    


<210>  163
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  163

Asp Asn Tyr Tyr Asp Ser Asn Val Tyr Asn Ser Tyr Tyr Phe Tyr Gly 
1               5                   10                  15      


Met Asp Val 
            


<210>  164
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  164

Thr Gly Thr Ser Ser Asp Val Gly Asn Tyr Asn His Val Ser 
1               5                   10                  


<210>  165
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  165

Asp Gln Tyr Tyr Asp Ile Leu Thr Pro Tyr Tyr Tyr Tyr Tyr Tyr Gly 
1               5                   10                  15      


Met Asp Val 
            


<210>  166
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  166

Asp Gly Tyr Cys Ser Ser Thr Ser Cys Tyr Gly Tyr Tyr Gly Met Asp 
1               5                   10                  15      


Val 
    


<210>  167
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  167

Gly Phe Thr Phe Ser Ser Tyr Ala Met His 
1               5                   10  


<210>  168
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  168

Asp Gln Tyr Tyr Asp Ile Leu Lys Gly Tyr Tyr Asn Val Asp Tyr Tyr 
1               5                   10                  15      


Tyr Gly Met Asp Val 
            20      


<210>  169
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  169

Asp Asn Tyr Phe Asp Ser Ser Val Tyr Asp Ser Ser Tyr Tyr Phe Tyr 
1               5                   10                  15      


Tyr Gly Met Asp Val 
            20      


<210>  170
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  170

Trp Ile Asn Ala Gly Asn Gly Tyr Thr Lys Tyr Ser Gln Asn Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  171
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  171

Asp Glu Tyr Tyr Glu Ser Gly Ser Ser Asn Tyr Tyr Tyr Tyr Gly Met 
1               5                   10                  15      


Asp Val 
        


<210>  172
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  172

Trp Ile Asn Ala Gly Asn Gly Tyr Thr Lys Tyr Ser Gln Thr Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  173
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  173

Asp Gln Phe Tyr Glu Thr Leu Thr Gly Tyr Tyr Asn Val Tyr Tyr Tyr 
1               5                   10                  15      


Tyr Gly Met Asp Val 
            20      


<210>  174
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  174

Trp Ile Asn Ala Gly Asn Gly Tyr Thr Lys Tyr Ser Gln Met Phe Gln 
1               5                   10                  15      


Asp 
    


<210>  175
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  175

Asp Glu Tyr Tyr Asp Ser Gly Ser Ser Asn Tyr Tyr Tyr Tyr Gly Met 
1               5                   10                  15      


Asp Val 
        


