                         SEQUENCE LISTING

<110>  UNIVERSITE D'AIX MARSEILLE et al.
 
<120>  Modulators of FPR2, compositions and uses thereof for modulating 
       influenza virus replication

<130>  B2208PC00

<160>  16    

<170>  PatentIn version 3.5

<210>  1
<211>  9751
<212>  DNA
<213>  Homo sapiens

<400>  1
aaactctgaa gaaggaaggg ctggacattc agattccttg acccttgaca tttggaagca       60

tgaactccag tctctcacag aaggctagag gtgaaggaac attcagacac attggtttct      120

aagaagagtc cgctgacaac atacccaagg tgtcttctga aaattataag aaatcctgag      180

tttctgttag gggattggct ccagctccat tgtccctccc ccatcattca gtagtctccg      240

cgaaagccct tagagccggt gttgctccac aggaagccaa gaagcacaca ggaaaaggag      300

cttagctgct ggtaagttgg ggactgacaa tttaaaattt atcaatggaa ctcctgctct      360

ctgacaaaca cctcctaaat tctagagcag tgctgtaatg gagcatccac ttgccacagg      420

tggcttttga gtgcctatgt ttctatcttg atctgaaatg tgcttaagtg taaaatatac      480

ttagtgtagt ttaatcatta gtatgatcaa aataatacaa tttatctcgt taataacttt      540

cattttggta acgtgttcca atgatttttt ttatttgcgg ggttaaatga aacatattat      600

tataattaat ttctcccaat gattttactt ttttaacatg gctactagaa agttgtaagt      660

cacgtgtgtg gctggcattt agggcttgca ttaccctgtc tctactaaaa atgcaaacaa      720

caaactagcc aggcgtagtg gtgggagcct gtaatcccag ctactcagga ggctgaggca      780

ggagaatcgc ttgaacctag gaggccgagg ttgcagtgag ccgatatcgt gccattgcac      840

tccagcctgg gcaagaagag tgaaactcta actcaaagat aaataaacat gtgaaggagc      900

caagtgtgag gagcttaaga ggaagagcat ggtaggcaga aggaacagag aaggcagaag      960

ccccgagatg acaatgagct gcatgttcaa ggaatcagag cccgttatgg gtggagccca     1020

gtgtgtccca cgagagtgca gagatgaggt ctgaggaatg cacagggcag gtccaggggt     1080

acttgaggga acttaagata aggataagtt agaagtttgg aagccattag aaggtgttga     1140

aaatagcatc accattttat tggacctttt tttttttttt ttttgagaca gaatcttgct     1200

ctgtcgccca ggctgaagtg cagtggcgca gtctcggctc actgcaaact ctgcctctca     1260

gggtcaagcg attctcctgc ctcagcctcc caagtagctg ggattacagg cacccgccat     1320

cacgcccagc taatttttgt gtttttttag tagagacggg gtttcatcat gttgggcagg     1380

ttggtcttga actcctgacc tcaggtgatc cacccacctc agcctcccaa agtgctggga     1440

ttacaggcat gagccactcc cggcccttat tggacttttt tttttttttt gagacagagt     1500

tttgctcttg ttgcccaggc tggagtgcaa tggcacgatc tcagctcact gcaacctccg     1560

cctccctggt tcaagcgatt ctcctgcgtc agcctcccga gcatctggaa ttacaggcac     1620

gtgccaccac gcccagctaa ttttgtattt ttagtagaga tggggtttct tcatgttggc     1680

caggttggtc tcgaactcct gacctctggt gacccacctg cctcggcctc ccaaagtgct     1740

gggattacag gtgtgagcca ctgcacctgg cccttattga actttttaaa agctcatttg     1800

gtttccttct ggagattgga ttgtagggca ggggaaagta ggaccaggaa caacctattt     1860

gcaaagttgg cgcaaacatt cctgcctgac aggaccatgg acacaggttg tagagataga     1920

gatggctctg gctgtgcatt cagcagattc tgtagataga attaatagga cttggatggg     1980

attgtggtga gagaaagtga aatgaaagat aagttctagt ttggaagttt taacaactga     2040

atgtttaaac tcaaatagac acaaaatatt ggaagagtgg caggtttggg aggatgagac     2100

aatcaactgt ttggttgagc cacgttaggt ttgaaatgtc tacgggactc ccgtggggag     2160

aggttatatc agactggagc accagagaga ggccaaggct gatagtttag atgaaaagag     2220

agcatgatat tttaagccct gagactggat aatatcacct atagaaagac tatatagaga     2280

taagagaggt ggggaacaag taaaagctgc gggacactcc taaatttaga gtcaaattta     2340

gagcagaaaa tactagcaaa ggggactgaa aagcggtggc caattgagct tcaaatgcaa     2400

gtgaaagtgt gttgtgtgta catttatcat ctcatggcac aggaaaaacg tgatttaagg     2460

agaaggaagc gatccaatgg gaagaagaga tccaatggat cctctatcac gaagatattg     2520

agataagaac caatatggat ttgcacccac tgcatttgca gccttgaggt cataagcatc     2580

ctcaggaaaa tgcaccaggt cagtgctaag gactggagtc aatacagact ggattcagga     2640

gaaaaagtga ggcagggaat caaagggagc aaacacagaa aactccttcc aaaatctggc     2700

tgcaaattct tttcatagaa agaattctct caggagaaat agggttaaca ccagaaagga     2760

atatagtcca agatcttttt ggttgttttt tgttttgttt tttggggtgg tttttatttt     2820

gtttttgttt agttttgttg ttgtttgttt gtttgttttt gagacggagt cactgttgcc     2880

caggctggag tgcagtggtg cgatctcagc tcactgcaac ctccgccttc cggtgttcaa     2940

gaggtcttcc tgcctcagct tcccaagtag ctgggattgc aagcgcgtgc catcacgtcc     3000

agctaatttt tgtattttta gtagagatga ggtttcacca tgttggccag tctggtctca     3060

aactcctggc ctcaagtgat ccacttgcct cagcttccct aaatgttggg attacaggtg     3120

tgagccacgg cacctggcca aggatggttt ctttttaaag ggaggggata tgatttatgt     3180

aatgtttatg taatagtgag aatgatctag tagaaataaa atcttgaggg tttgtttttg     3240

gcagaaaatg gaaggacaaa tgcaggggga aagtttgtgg gaagatgaga gggcatcctg     3300

ggccaatgca gggagggaaa ttattggaaa gaacaagaag tctttattca cagtgacaga     3360

ggcaggtaga ctgagggtca ggggaggacc ggctgaaaat ttcacatcta gttattacca     3420

ttttctcatt ataatgtcag tcaagggcat ctgctgagag tgggaaaaac agagtaaatg     3480

aggtactttt tggagaaagc aggactgaaa taattaaggt gtgggatagc gagtgcgctg     3540

gagaagtaga gtaacctaat gaggaactgc tgagttttca tttgaaatct gtggtcataa     3600

attcaattgc aaccctcgat aattgtgaaa gtcacttccg ctctctgagc cgtactttcc     3660

tacctgttac acaaggacag cacttgtccc aaagcaaggg tattgtaatc agagatgata     3720

aaatatatag tgactggcac atattaagga ctcaccaaat agcagacctc ataatcagta     3780

caggtatcat ctgtggttcg cagttctcct ccttacatta caactagggt ggacccaaaa     3840

ctttgcaatt tttgccttgt taatttgtcc tcacctgtca ttgcacaatc atccttcctt     3900

gttgcatcaa catttttttt tttctgagac agagtctcgc tctttcaccc aggctggagt     3960

gctgtggcac gatcttggct cactgcaacc tctgcctccc agactcaagt gattctcctg     4020

cctcagcctc ccaagtaact gggattacag gcacccacca ccatgcccag ctaatttttg     4080

tatttttagt agagacaggg tttcaccatg ttggccaggc tggtttcaaa ttcctggcct     4140

caagtgatcc acctgtcttg gcctcccaaa gtgctaggat tacaggcgtg agccactgcg     4200

cccagcctgt atcaacattt taaaatgaat ttgaaattat ggatagatca tgtcttctaa     4260

gtgtcttgta gaatgtttgg agtgtggata gagaaaatct gagtctgttg aggaactatg     4320

gggtggaaaa gggttaacag cacaattctg ttgtaatcaa tctggctgag ctccaattct     4380

gtctctactc tttctacctg gtaacgttga acaattaacg cagcccatct aagtcttaac     4440

ttcctcatct gtacaatggt tatactaatt atcaggctgc tgcaaaagta cttgtggttt     4500

ttgatattat tttcaatggc aaaaacagcg ttacttttgc accaacctaa tatcactaag     4560

attaatcaat attcactgtg tctcaggagt gctcagtgtt cacacatatt aacacagccc     4620

atccacagat cctgtgagag gcgttgatag ggttaaagga aaagctcttg gtgtgtgggt     4680

aatgttcata agtagaaaca actattgcta tgagcatcgt tcttgtcctg accttgaact     4740

tcataatgga ttgagcccca cgacacagca cacagcctgg tgagggccaa gagttcccat     4800

ttgtcataga tatactcagt ctagcctaaa agatttccac atctattctc acttaatcct     4860

cacctgaaag ttagacttca ccataaaatt gtcctcgttc tgcagagcag aaaactgagg     4920

ctcaaagaga tatcactgac taaaaactca tagtgaggag acatcacaga tgagattaga     4980

agagagatgt agctgacttc agagcccagt atatatatat attttagaca gagtctcgct     5040

ctgtccccca ggctggagtg cagtggcacg gctcactgca acctccgcct cccgggttca     5100

agcgattctc ctgcctcagc ctcccgagta gctgggactg caagtgcatg ccaccaggcc     5160

cggctaattt tttgtatttt cggtagagac ggggcttcac cgtattgccc agggtggtct     5220

ggaactcctg acctcaggca atccaccccc cttggcctcc caaagtgttg ggattacagg     5280

cgtgagccac cgtatctggc tgagcccagt attctttgta acagtgactc tcaattgggg     5340

gtgactttgc ctccgagggg acctttgaca atgtttatgg aacctgttga ttgtcatttc     5400

tggagaagga gttgctactg gtgtctgtgg atagaggcca ggggggctgc tcaacatcct     5460

actgtgtcca gaacagtctg ccacaacgaa gaattaccca gacccagatg tcaaaggtgc     5520

caaggttgag aaaccctgag ctacattaaa taacgtccca tggaatacct cagtgaaact     5580

cactggtaat agcaggaaga aaaggaggaa ataaggaaaa ggaagaaggc taaaaatcac     5640

cagactgagg catagcccta tcctagtaat cttgggggaa tccctttcaa aggcaggact     5700

tccgtatgca aaggcagtgg ctctggagtt gttcatctcg gtttccgtat cttgctgcct     5760

ccactgactg gctgggcatg atgttgaaaa aaactacaga agtccccggg ccatgaattc     5820

ccccagatgt gatggctgtt tcccaatgtt attatgagca ttagatgtga acaagtgcta     5880

tggaattgct atttctctta aagatgctga atagcccagt ctgagatgat tctcaaattc     5940

tcatggccat agcaaatcat cctggctttt acacatacag attctagaat gagatttatg     6000

gatataattg tttttcattt ttattataag ttcaggggta tatgtgcagg tttgttatac     6060

aggtaaactt gtatcctggt gttttcttgt acagattatt tcatcactga gatattaagc     6120

ctaataccca ctacttattt ttcctgatcc tgtccctccc ctcaccctcc accttccggt     6180

aggccccagt gttcccctct ttgtgtccat gtgttctcat catttacctc ccatttgtaa     6240

atgagaacat gtggtatttg gttttctgtt cctgcattag tttgctaagg ataatgaata     6300

caattttaac aggcagcctg gatgtttctg ataaagtcca cagaccacgg cataagaaaa     6360

tgtgctcagg tgacgtggga ctttgtgttg aactggatac aaatattaca gatgtgatcc     6420

ggaccagagg cagggactac atgttttggg tttttgttct taaaagaaaa aaacaaaaac     6480

aaaaaaactt gatctgagaa gctctgaagg gtcatattct tacaatgtta ttgtccacaa     6540

tttagtcacg tgtccactac caaagcaatc ccttgcaaag taaaagggat tctggttagt     6600

gctaattaga ctagtcagga tttactccca acatggagaa aagacacctt ctctgcaggg     6660

tgagtaacta aacacaattg tggtttttca agcagagaag aatggggaac cgttgctggg     6720

tgggcaacca gcaatatctg tcaagcgtaa gggtttagaa gtcagaccat gccaaactga     6780

agtcctgaat ctattatcta ctacctaagt gaccttcaac acatttcaca attgccctga     6840

gctttcattt attctaatga aaactagaag taatgaatat tacatagcta ttacataggc     6900

caaaccggat cccatatgta gtaattaaca caatgcatag tctctaataa gaacttcaca     6960

agtattaata caacttatta ttcttatagt ctttatccca cagacaccaa agctatacaa     7020

atcggcactg attatttgca ttccaaacag agaagagctc cacatcaagc agggacaggg     7080

aaaagcagag ggtagaaagc agagatggaa ctctctttgc tgacttcctc tagtgcagaa     7140

tcctcaggat ataacatact actacatgtt accagtgact cctcaaaatt ctcttcaaca     7200

ataacctcaa gccaaaccct caaactttat cttgagtact agccaagcaa taggtcaagg     7260

gttctcacag tttgagggac aggagttggg agactggaag aacctggggc tgaaagagat     7320

tgcagagctt gccagcatgt ttgcattgaa tggtgggaga cacagatgtg agccttctga     7380

ttctgagtca tgtgccttcc tcacaatgct gaggctgcct atgctcaatt ttccattgtc     7440

catacaacat aagttcagta tgagccttgt aatcctcttg gtgaagtgat cagcccgata     7500

agcgaaatgc atattgataa tgatgggaat atggaggact atcccttccc aaaggagcat     7560

ccaagagaat gccaattcta tagcaccgtt gtcaacaagg cttggtagat agagtgggtc     7620

tcctggtagg agtgggagct ttagtggaag ttgatgtgag ctataaatac agatgctgta     7680

agatggttcc acagctgaga aatggccatt gttggaatgt ttcaggtgct gctggcaaga     7740

tggaaaccaa cttctccact cctctgaatg aatatgaaga agtgtcctat gagtctgctg     7800

gctacactgt tctgcggatc ctcccattgg tggtgcttgg ggtcaccttt gtcctcgggg     7860

tcctgggcaa tgggcttgtg atctgggtgg ctggattccg gatgacacgc acagtcacca     7920

ccatctgtta cctgaacctg gccctggctg acttttcttt cacggccaca ttaccattcc     7980

tcattgtctc catggccatg ggagaaaaat ggccttttgg ctggttcctg tgtaagttaa     8040

ttcacatcgt ggtggacatc aacctctttg gaagtgtctt cttgattggt ttcattgcac     8100

tggaccgctg catttgtgtc ctgcatccag tctgggccca gaaccaccgc actgtgagtc     8160

tggccatgaa ggtgatcgtc ggaccttgga ttcttgctct agtccttacc ttgccagttt     8220

tcctcttttt gactacagta actattccaa atggggacac atactgtact ttcaactttg     8280

catcctgggg tggcacccct gaggagaggc tgaaggtggc cattaccatg ctgacagcca     8340

gagggattat ccggtttgtc attggcttta gcttgccgat gtccattgtt gccatctgct     8400

atgggctcat tgcagccaag atccacaaaa agggcatgat taaatccagc cgtcccttac     8460

gggtcctcac tgctgtggtg gcttctttct tcatctgttg gtttcccttt caactggttg     8520

cccttctggg caccgtctgg ctcaaagaga tgttgttcta tggcaagtac aaaatcattg     8580

acatcctggt taacccaacg agctccctgg ccttcttcaa cagctgcctc aaccccatgc     8640

tttacgtctt tgtgggccaa gacttccgag agagactgat ccactccctg cccaccagtc     8700

tggagagggc cctgtctgag gactcagccc caactaatga cacggctgcc aattctgctt     8760

cacctcctgc agagactgag ttacaggcaa tgtgaggatg gggtcaggga tattttgagt     8820

tctgttcatc ctaccctaat gccagttcca gcttcatcta cccttgagtc atattgaggc     8880

attcaaggat gcacagctca agtatttatt caggaaaaat gcttttgtgt ccctgatttg     8940

gggctaagaa atagacagtc aggctactaa aatattagtg ttattttttg ttttttgact     9000

tctgcctata ccctggggta agtggagttg ggaaatacaa gaagagaaag accagtgggg     9060

atttgtaaga cttagatgag atagcgcata ataaggggaa gactttaaag tataaagtaa     9120

aatgtttgct gtaggttttt tatagctatt aaaaaaaatc agattatgga agttttcttc     9180

tatttttagt ttgctaagag ttttctgttt ctttttctta catcatgagt ggactttgca     9240

ttttatcaaa tgcattttct acatgtatta agatggtcat attattcttc ttcttttatg     9300

taaatcatta taaataatgt tcattaagtt ctgaatgtta aactactctt gaattcctgg     9360

aataaaccac acttagtcct gatgtacttt aaatatttat atctcacagg agttggttag     9420

aatttctgtg tttatgttta tatactgtta tttcactttt tctactatcc ttgctaagtt     9480

ttcatagaaa ataaggaaca aagagaaact tgtaatggtc tctgaaaagg aattgagaag     9540

taattcctct gattctgttt tctggtgtta tatctttatt aaatattcag aaaaattcac     9600

cagtgaagcc aacttggtct tgtgttttct ttctgggaag atttttaata acaagtttgt     9660

tttctttaac agtgattaga ctcttctgtt ttttggtttt ttgttttttc ctatctgtca     9720

gttttggtaa actgaatttc aaggagtttg g                                    9751


<210>  2
<211>  351
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Glu Thr Asn Phe Ser Thr Pro Leu Asn Glu Tyr Glu Glu Val Ser 
1               5                   10                  15      


Tyr Glu Ser Ala Gly Tyr Thr Val Leu Arg Ile Leu Pro Leu Val Val 
            20                  25                  30          


Leu Gly Val Thr Phe Val Leu Gly Val Leu Gly Asn Gly Leu Val Ile 
        35                  40                  45              


Trp Val Ala Gly Phe Arg Met Thr Arg Thr Val Thr Thr Ile Cys Tyr 
    50                  55                  60                  


Leu Asn Leu Ala Leu Ala Asp Phe Ser Phe Thr Ala Thr Leu Pro Phe 
65                  70                  75                  80  


Leu Ile Val Ser Met Ala Met Gly Glu Lys Trp Pro Phe Gly Trp Phe 
                85                  90                  95      


Leu Cys Lys Leu Ile His Ile Val Val Asp Ile Asn Leu Phe Gly Ser 
            100                 105                 110         


Val Phe Leu Ile Gly Phe Ile Ala Leu Asp Arg Cys Ile Cys Val Leu 
        115                 120                 125             


His Pro Val Trp Ala Gln Asn His Arg Thr Val Ser Leu Ala Met Lys 
    130                 135                 140                 


Val Ile Val Gly Pro Trp Ile Leu Ala Leu Val Leu Thr Leu Pro Val 
145                 150                 155                 160 


Phe Leu Phe Leu Thr Thr Val Thr Ile Pro Asn Gly Asp Thr Tyr Cys 
                165                 170                 175     


Thr Phe Asn Phe Ala Ser Trp Gly Gly Thr Pro Glu Glu Arg Leu Lys 
            180                 185                 190         


Val Ala Ile Thr Met Leu Thr Ala Arg Gly Ile Ile Arg Phe Val Ile 
        195                 200                 205             


Gly Phe Ser Leu Pro Met Ser Ile Val Ala Ile Cys Tyr Gly Leu Ile 
    210                 215                 220                 


Ala Ala Lys Ile His Lys Lys Gly Met Ile Lys Ser Ser Arg Pro Leu 
225                 230                 235                 240 


Arg Val Leu Thr Ala Val Val Ala Ser Phe Phe Ile Cys Trp Phe Pro 
                245                 250                 255     


Phe Gln Leu Val Ala Leu Leu Gly Thr Val Trp Leu Lys Glu Met Leu 
            260                 265                 270         


Phe Tyr Gly Lys Tyr Lys Ile Ile Asp Ile Leu Val Asn Pro Thr Ser 
        275                 280                 285             


Ser Leu Ala Phe Phe Asn Ser Cys Leu Asn Pro Met Leu Tyr Val Phe 
    290                 295                 300                 


Val Gly Gln Asp Phe Arg Glu Arg Leu Ile His Ser Leu Pro Thr Ser 
305                 310                 315                 320 


Leu Glu Arg Ala Leu Ser Glu Asp Ser Ala Pro Thr Asn Asp Thr Ala 
                325                 330                 335     


Ala Asn Ser Ala Ser Pro Pro Ala Glu Thr Glu Leu Gln Ala Met 
            340                 345                 350     


<210>  3
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FPR2 inhibitor

<400>  3

Trp Arg Trp Trp Trp Trp 
1               5       


<210>  4
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FPR2 inhibitor PBP10

<400>  4

Gln Arg Leu Phe Gln Val Lys Gly Arg Arg 
1               5                   10  


<210>  5
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FLFLF peptide

<400>  5

Phe Leu Phe Leu Phe 
1               5   


<210>  6
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  WKYMVM peptide

<400>  6

Trp Lys Tyr Met Val Met 
1               5       


<210>  7
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CGEN-855A

<400>  7

Thr Ile Pro Met Phe Val Pro Glu Ser Thr Ser Lys Leu Gln Lys Phe 
1               5                   10                  15      


Thr Ser Trp Phe Met 
            20      


<210>  8
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PSMalpha3

<400>  8

Met Glu Phe Val Ala Lys Leu Phe Lys Phe Phe Lys Asp Leu Leu Gly 
1               5                   10                  15      


Lys Phe Leu Gly Asn Asn 
            20          


<210>  9
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MMK1

<400>  9

Leu Glu Ser Ile Phe Arg Ser Leu Leu Phe Arg Val Met 
1               5                   10              


<210>  10
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PAR4 agonist

<400>  10

Ala Tyr Pro Gly Lys Phe 
1               5       


<210>  11
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Viral NS1 Forward Primer

<400>  11
ctgtgtcaag ctttcaggta ga                                                22


<210>  12
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Viral NS1 Reverse primer

<400>  12
ggtacagagg ccatggtcat                                                   20


<210>  13
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human GADPH forward primer

<400>  13
gaaggtgaag gtcggagt                                                     18


<210>  14
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human GADPH reverse primer

<400>  14
gaagatggtg atgggatttc                                                   20


<210>  15
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Uni12 primer

<400>  15
agcaaaagca gg                                                           12


<210>  16
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GAPDH RT primer

<400>  16
gagatgatga cccttttggc                                                   20


