                         SEQUENCE LISTING

<110>  FUNDACI INSTITUT DE RECERCA BIOMDICA (IRB BARCELONA)
       KATHOLIEKE UNIVERSITEIT LEUVEN
 
<120>  AMYLOID BETA PEPTIDE OLIGOMERS AND USES THEREOF

<130>  P12700PC00

<150>  EP16382123
<151>  2016-03-21

<160>  28    

<170>  PatentIn version 3.5

<210>  1
<211>  42
<212>  PRT
<213>  Homo sapiens

<400>  1

Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val His His Gln Lys 
1               5                   10                  15      


Leu Val Phe Phe Ala Glu Asp Val Gly Ser Asn Lys Gly Ala Ile Ile 
            20                  25                  30          


Gly Leu Met Val Gly Gly Val Val Ile Ala 
        35                  40          


<210>  2
<211>  43
<212>  PRT
<213>  Homo sapiens

<400>  2

Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val His His Gln Lys 
1               5                   10                  15      


Leu Val Phe Phe Ala Glu Asp Val Gly Ser Asn Lys Gly Ala Ile Ile 
            20                  25                  30          


Gly Leu Met Val Gly Gly Val Val Ile Ala Thr 
        35                  40              


<210>  3
<211>  44
<212>  PRT
<213>  Homo sapiens

<400>  3

Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val His His Gln Lys 
1               5                   10                  15      


Leu Val Phe Phe Ala Glu Asp Val Gly Ser Asn Lys Gly Ala Ile Ile 
            20                  25                  30          


Gly Leu Met Val Gly Gly Val Val Ile Ala Thr Val 
        35                  40                  


<210>  4
<211>  45
<212>  PRT
<213>  Homo sapiens

<400>  4

Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val His His Gln Lys 
1               5                   10                  15      


Leu Val Phe Phe Ala Glu Asp Val Gly Ser Asn Lys Gly Ala Ile Ile 
            20                  25                  30          


Gly Leu Met Val Gly Gly Val Val Ile Ala Thr Val Ile 
        35                  40                  45  


<210>  5
<211>  46
<212>  PRT
<213>  Homo sapiens

<400>  5

Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val His His Gln Lys 
1               5                   10                  15      


Leu Val Phe Phe Ala Glu Asp Val Gly Ser Asn Lys Gly Ala Ile Ile 
            20                  25                  30          


Gly Leu Met Val Gly Gly Val Val Ile Ala Thr Val Ile Val 
        35                  40                  45      


<210>  6
<211>  47
<212>  PRT
<213>  Homo sapiens

<400>  6

Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val His His Gln Lys 
1               5                   10                  15      


Leu Val Phe Phe Ala Glu Asp Val Gly Ser Asn Lys Gly Ala Ile Ile 
            20                  25                  30          


Gly Leu Met Val Gly Gly Val Val Ile Ala Thr Val Ile Val Ile 
        35                  40                  45          


<210>  7
<211>  49
<212>  PRT
<213>  Homo sapiens

<400>  7

Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val His His Gln Lys 
1               5                   10                  15      


Leu Val Phe Phe Ala Glu Asp Val Gly Ser Asn Lys Gly Ala Ile Ile 
            20                  25                  30          


Gly Leu Met Val Gly Gly Val Val Ile Ala Thr Val Ile Val Ile Thr 
        35                  40                  45              


Leu 
    


<210>  8
<211>  55
<212>  PRT
<213>  Homo sapiens

<400>  8

Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val His His Gln Lys 
1               5                   10                  15      


Leu Val Phe Phe Ala Glu Asp Val Gly Ser Asn Lys Gly Ala Ile Ile 
            20                  25                  30          


Gly Leu Met Val Gly Gly Val Val Ile Ala Thr Val Ile Val Ile Thr 
        35                  40                  45              


Leu Val Met Leu Lys Lys Lys 
    50                  55  


<210>  9
<211>  42
<212>  PRT
<213>  Homo sapiens


<220>
<221>  VARIANT
<222>  (6)..(6)
<223>  /replace="Arg"

<220>
<221>  VARIANT
<222>  (7)..(7)
<223>  /replace="Asn"

<220>
<221>  VARIANT
<222>  (21)..(21)
<223>  /replace="Gly"

<220>
<221>  VARIANT
<222>  (22)..(22)
<223>  /replace="Gly"

/replace="Gln"

/replace="Lys"

/replace=""

<220>
<221>  VARIANT
<222>  (23)..(23)
<223>  /replace="Asn"

<400>  9

Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val His His Gln Lys 
1               5                   10                  15      


Leu Val Phe Phe Ala Glu Asp Val Gly Ser Asn Lys Gly Ala Ile Ile 
            20                  25                  30          


Gly Leu Met Val Gly Gly Val Val Ile Ala 
        35                  40          


<210>  10
<211>  41
<212>  PRT
<213>  Homo sapiens

<400>  10

Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val His His Gln Lys Leu 
1               5                   10                  15      


Val Phe Phe Ala Glu Asp Val Gly Ser Asn Lys Gly Ala Ile Ile Gly 
            20                  25                  30          


Leu Met Val Gly Gly Val Val Ile Ala 
        35                  40      


<210>  11
<211>  40
<212>  PRT
<213>  Homo sapiens

<400>  11

Glu Phe Arg His Asp Ser Gly Tyr Glu Val His His Gln Lys Leu Val 
1               5                   10                  15      


Phe Phe Ala Glu Asp Val Gly Ser Asn Lys Gly Ala Ile Ile Gly Leu 
            20                  25                  30          


Met Val Gly Gly Val Val Ile Ala 
        35                  40  


<210>  12
<211>  39
<212>  PRT
<213>  Homo sapiens

<400>  12

Phe Arg His Asp Ser Gly Tyr Glu Val His His Gln Lys Leu Val Phe 
1               5                   10                  15      


Phe Ala Glu Asp Val Gly Ser Asn Lys Gly Ala Ile Ile Gly Leu Met 
            20                  25                  30          


Val Gly Gly Val Val Ile Ala 
        35                  


<210>  13
<211>  38
<212>  PRT
<213>  Homo sapiens

<400>  13

Arg His Asp Ser Gly Tyr Glu Val His His Gln Lys Leu Val Phe Phe 
1               5                   10                  15      


Ala Glu Asp Val Gly Ser Asn Lys Gly Ala Ile Ile Gly Leu Met Val 
            20                  25                  30          


Gly Gly Val Val Ile Ala 
        35              


<210>  14
<211>  36
<212>  PRT
<213>  Homo sapiens

<400>  14

Asp Ser Gly Tyr Glu Val His His Gln Lys Leu Val Phe Phe Ala Glu 
1               5                   10                  15      


Asp Val Gly Ser Asn Lys Gly Ala Ile Ile Gly Leu Met Val Gly Gly 
            20                  25                  30          


Val Val Ile Ala 
        35      


<210>  15
<211>  35
<212>  PRT
<213>  Homo sapiens

<400>  15

Ser Gly Tyr Glu Val His His Gln Lys Leu Val Phe Phe Ala Glu Asp 
1               5                   10                  15      


Val Gly Ser Asn Lys Gly Ala Ile Ile Gly Leu Met Val Gly Gly Val 
            20                  25                  30          


Val Ile Ala 
        35  


<210>  16
<211>  34
<212>  PRT
<213>  Homo sapiens

<400>  16

Gly Tyr Glu Val His His Gln Lys Leu Val Phe Phe Ala Glu Asp Val 
1               5                   10                  15      


Gly Ser Asn Lys Gly Ala Ile Ile Gly Leu Met Val Gly Gly Val Val 
            20                  25                  30          


Ile Ala 
        


<210>  17
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  17

Glu Val His His Gln Lys Leu Val Phe Phe Ala Glu Asp Val Gly Ser 
1               5                   10                  15      


Asn Lys Gly Ala Ile Ile Gly Leu Met Val Gly Gly Val Val Ile Ala 
            20                  25                  30          


<210>  18
<211>  42
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  PHOSPHORYLATION

<400>  18

Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val His His Gln Lys 
1               5                   10                  15      


Leu Val Phe Phe Ala Glu Asp Val Gly Ser Asn Lys Gly Ala Ile Ile 
            20                  25                  30          


Gly Leu Met Val Gly Gly Val Val Ile Ala 
        35                  40          


<210>  19
<211>  42
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  PHOSPHORYLATION

<400>  19

Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val His His Gln Lys 
1               5                   10                  15      


Leu Val Phe Phe Ala Glu Asp Val Gly Ser Asn Lys Gly Ala Ile Ile 
            20                  25                  30          


Gly Leu Met Val Gly Gly Val Val Ile Ala 
        35                  40          


<210>  20
<211>  42
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES
<222>  (26)..(26)
<223>  PHOSPHORYLATION

<400>  20

Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val His His Gln Lys 
1               5                   10                  15      


Leu Val Phe Phe Ala Glu Asp Val Gly Ser Asn Lys Gly Ala Ile Ile 
            20                  25                  30          


Gly Leu Met Val Gly Gly Val Val Ile Ala 
        35                  40          


<210>  21
<211>  42
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  PHOSPHORYLATION

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  PHOSPHORYLATION

<400>  21

Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val His His Gln Lys 
1               5                   10                  15      


Leu Val Phe Phe Ala Glu Asp Val Gly Ser Asn Lys Gly Ala Ile Ile 
            20                  25                  30          


Gly Leu Met Val Gly Gly Val Val Ile Ala 
        35                  40          


<210>  22
<211>  42
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  PHOSPHORYLATION

<220>
<221>  MOD_RES
<222>  (26)..(26)
<223>  PHOSPHORYLATION

<400>  22

Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val His His Gln Lys 
1               5                   10                  15      


Leu Val Phe Phe Ala Glu Asp Val Gly Ser Asn Lys Gly Ala Ile Ile 
            20                  25                  30          


Gly Leu Met Val Gly Gly Val Val Ile Ala 
        35                  40          


<210>  23
<211>  42
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  PHOSPHORYLATION

<220>
<221>  MOD_RES
<222>  (26)..(26)
<223>  PHOSPHORYLATION

<400>  23

Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val His His Gln Lys 
1               5                   10                  15      


Leu Val Phe Phe Ala Glu Asp Val Gly Ser Asn Lys Gly Ala Ile Ile 
            20                  25                  30          


Gly Leu Met Val Gly Gly Val Val Ile Ala 
        35                  40          


<210>  24
<211>  42
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  PHOSPHORYLATION

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  PHOSPHORYLATION

<220>
<221>  MOD_RES
<222>  (26)..(26)
<223>  PHOSPHORYLATION

<400>  24

Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val His His Gln Lys 
1               5                   10                  15      


Leu Val Phe Phe Ala Glu Asp Val Gly Ser Asn Lys Gly Ala Ile Ile 
            20                  25                  30          


Gly Leu Met Val Gly Gly Val Val Ile Ala 
        35                  40          


<210>  25
<211>  42
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  NITRATION

<400>  25

Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val His His Gln Lys 
1               5                   10                  15      


Leu Val Phe Phe Ala Glu Asp Val Gly Ser Asn Lys Gly Ala Ile Ile 
            20                  25                  30          


Gly Leu Met Val Gly Gly Val Val Ile Ala 
        35                  40          


<210>  26
<211>  42
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (35)..(35)
<223>  OXIDATION

<400>  26

Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val His His Gln Lys 
1               5                   10                  15      


Leu Val Phe Phe Ala Glu Asp Val Gly Ser Asn Lys Gly Ala Ile Ile 
            20                  25                  30          


Gly Leu Met Val Gly Gly Val Val Ile Ala 
        35                  40          


<210>  27
<211>  40
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  PYROGLUTAMINATION

<400>  27

Glu Phe Arg His Asp Ser Gly Tyr Glu Val His His Gln Lys Leu Val 
1               5                   10                  15      


Phe Phe Ala Glu Asp Val Gly Ser Asn Lys Gly Ala Ile Ile Gly Leu 
            20                  25                  30          


Met Val Gly Gly Val Val Ile Ala 
        35                  40  


<210>  28
<211>  32
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  PYROGLUTAMINATION

<400>  28

Glu Val His His Gln Lys Leu Val Phe Phe Ala Glu Asp Val Gly Ser 
1               5                   10                  15      


Asn Lys Gly Ala Ile Ile Gly Leu Met Val Gly Gly Val Val Ile Ala 
            20                  25                  30          


