               SEQUENCE LISTING

<110> Bayer

<120> Hepsin as therapeutic target

<130> BHC153053

<160> 22

<170> BiSSAP 1.3

<210> 1
<211> 1639
<212> DNA
<213> Homo sapiens

<400> 1
tcgagcccgc tttccaggga ccctacctga gggcccacag gtgaggcagc ctggcctagc      60

aggccccacg ccaccgcctc tgcctccagg ccgcccgctg ctgcggggcc accatgctcc     120

tgcccaggcc tggagactga cccgaccccg gcactacctc gaggctccgc ccccacctgc     180

tggaccccag ggtcccaccc tggcccagga ggtcagccag ggaatcatta acaagaggca     240

gtgacatggc gcagaaggag gtgcaggtca gctctgcgga cgctcggctc atggtctttg     300

acaagacgga agggacgtgg cggctgctgt gctcctcgcg ctccaacgcc agggtagccg     360

gactcagctg cgaggagatg ggcttcctca gggcactgac ccactccgag ctggacgtgc     420

gaacggcggg cgccaatggc acgtcgggct tcttctgtgt ggacgagggg aggctgcccc     480

acacccagag gctgctggag gtcatctccg tgtgtgattg ccccagaggc cgtttcttgg     540

ccgccatctg ccaagactgt ggccgcagga agctgcccgt ggaccgcatc gtgggaggcc     600

gggacaccag cttgggccgg tggccgtggc aagtcagcct tcgctatgat ggagcacacc     660

tctgtggggg atccctgctc tccggggact gggtgctgac agccgcccac tgcttcccgg     720

agcggaaccg ggtcctgtcc cgatggcgag tgtttgccgg tgccgtggcc caggcctctc     780

cccacggtct gcagctgggg gtgcaggctg tggtctacca cgggggctat cttccctttc     840

gggaccccaa cagcgaggag aacagcaacg atattgccct ggtccacctc tccagtcccc     900

tgcccctcac agaatacatc cagcctgtgt gcctcccagc tgccggccag gccctggtgg     960

atggcaagat ctgtaccgtg acgggctggg gcaacacgca gtactatggc caacaggccg    1020

gggtactcca ggaggctcga gtccccataa tcagcaatga tgtctgcaat ggcgctgact    1080

tctatggaaa ccagatcaag cccaagatgt tctgtgctgg ctaccccgag ggtggcattg    1140

atgcctgcca gggcgacagc ggtggtccct ttgtgtgtga ggacagcatc tctcggacgc    1200

cacgttggcg gctgtgtggc attgtgagtt ggggcactgg ctgtgccctg gcccagaagc    1260

caggcgtcta caccaaagtc agtgacttcc gggagtggat cttccaggcc ataaagactc    1320

actccgaagc cagcggcatg gtgacccagc tctgaccggt ggcttctcgc tgcgcagcct    1380

ccagggcccg aggtgatccc ggtggtggga tccacgctgg gcctaggatg ggacgttttt    1440

cttcttgggc ccggtccaca ggtccaagga caccctccct ccagggtcct ctcttccaca    1500

gtggcgggcc cactcagccc cgagaccacc caacctcacc ctcctgaccc ccatgtaaat    1560

attgttctgc tgtctgggac tcctgtctag gtgcccctga tgacgggatg ctctttaaat    1620

aataaagatg gttttgatt                                                 1639


<210> 2
<211> 2219
<212> DNA
<213> Homo sapiens

<400> 2
tcgagcccgc tttccaggga ccctacctga gggcccacag gtgaggcagc ctggcctagc      60

aggccccacg ccaccgcctc tgcctccagg ccgcccgctg ctgcggggcc accatgctcc     120

tgcccaggcc tggagactga cccgaccccg gcactacctc gaggctccgc ccccacctgc     180

tggaccccag ggtaaggaca agggccccca gactcacagt tccagccctg aggacagggg     240

ttccctcatc cccccaccca gcctaatgcc cacctcctaa tagaggggtt cctggggacc     300

tgaagagggg gcactatgac gtccccccaa gcacctaggt gttctgtcct gctcttcctt     360

cagactcagc cgttggaccc cagtcctttc ctccccagac ccaggagttc cagccctcag     420

gcccctcctc cctcatacta gggagtcctg gcccccaaat tcctcctttc ccaagactta     480

tgatttcagg tcctcagctg tctcctccct caaaccggga tcctcagtcc cctgctccac     540

caggctcagg catgggggtc cccatccctg caaatccagg cgtccccccg ctgctggtca     600

gacactgacc ccatccttga acccagccca atctgcgtcc gtgatcacgg cgtgctctgg     660

ccaaggccca gtccctacag cctgcctgga tggacgcctg ggactggggg cgccaggact     720

gggctgggct gggctccccc aggccctgcc tccccgtcca tctcctcaca ggtcccaccc     780

tggcccagga ggtcagccag ggaatcatta acaagaggca gtgacatggc gcagaaggag     840

gtgcaggtca gctctgcgga cgctcggctc atggtctttg acaagacgga agggacgtgg     900

cggctgctgt gctcctcgcg ctccaacgcc agggtagccg gactcagctg cgaggagatg     960

ggcttcctca gggcactgac ccactccgag ctggacgtgc gaacggcggg cgccaatggc    1020

acgtcgggct tcttctgtgt ggacgagggg aggctgcccc acacccagag gctgctggag    1080

gtcatctccg tgtgtgattg ccccagaggc cgtttcttgg ccgccatctg ccaagactgt    1140

ggccgcagga agctgcccgt ggaccgcatc gtgggaggcc gggacaccag cttgggccgg    1200

tggccgtggc aagtcagcct tcgctatgat ggagcacacc tctgtggggg atccctgctc    1260

tccggggact gggtgctgac agccgcccac tgcttcccgg agcggaaccg ggtcctgtcc    1320

cgatggcgag tgtttgccgg tgccgtggcc caggcctctc cccacggtct gcagctgggg    1380

gtgcaggctg tggtctacca cgggggctat cttccctttc gggaccccaa cagcgaggag    1440

aacagcaacg atattgccct ggtccacctc tccagtcccc tgcccctcac agaatacatc    1500

cagcctgtgt gcctcccagc tgccggccag gccctggtgg atggcaagat ctgtaccgtg    1560

acgggctggg gcaacacgca gtactatggc caacaggccg gggtactcca ggaggctcga    1620

gtccccataa tcagcaatga tgtctgcaat ggcgctgact tctatggaaa ccagatcaag    1680

cccaagatgt tctgtgctgg ctaccccgag ggtggcattg atgcctgcca gggcgacagc    1740

ggtggtccct ttgtgtgtga ggacagcatc tctcggacgc cacgttggcg gctgtgtggc    1800

attgtgagtt ggggcactgg ctgtgccctg gcccagaagc caggcgtcta caccaaagtc    1860

agtgacttcc gggagtggat cttccaggcc ataaagactc actccgaagc cagcggcatg    1920

gtgacccagc tctgaccggt ggcttctcgc tgcgcagcct ccagggcccg aggtgatccc    1980

ggtggtggga tccacgctgg gcctaggatg ggacgttttt cttcttgggc ccggtccaca    2040

ggtccaagga caccctccct ccagggtcct ctcttccaca gtggcgggcc cactcagccc    2100

cgagaccacc caacctcacc ctcctgaccc ccatgtaaat attgttctgc tgtctgggac    2160

tcctgtctag gtgcccctga tgacgggatg ctctttaaat aataaagatg gttttgatt     2219


<210> 3
<211> 369
<212> PRT
<213> Homo sapiens

<400> 3
Met Ala Gln Lys Glu Val Gln Val Ser Ser Ala Asp Ala Arg Leu Met 
1               5                   10                  15      
Val Phe Asp Lys Thr Glu Gly Thr Trp Arg Leu Leu Cys Ser Ser Arg 
            20                  25                  30          
Ser Asn Ala Arg Val Ala Gly Leu Ser Cys Glu Glu Met Gly Phe Leu 
        35                  40                  45              
Arg Ala Leu Thr His Ser Glu Leu Asp Val Arg Thr Ala Gly Ala Asn 
    50                  55                  60                  
Gly Thr Ser Gly Phe Phe Cys Val Asp Glu Gly Arg Leu Pro His Thr 
65                  70                  75                  80  
Gln Arg Leu Leu Glu Val Ile Ser Val Cys Asp Cys Pro Arg Gly Arg 
                85                  90                  95      
Phe Leu Ala Ala Ile Cys Gln Asp Cys Gly Arg Arg Lys Leu Pro Val 
            100                 105                 110         
Asp Arg Ile Val Gly Gly Arg Asp Thr Ser Leu Gly Arg Trp Pro Trp 
        115                 120                 125             
Gln Val Ser Leu Arg Tyr Asp Gly Ala His Leu Cys Gly Gly Ser Leu 
    130                 135                 140                 
Leu Ser Gly Asp Trp Val Leu Thr Ala Ala His Cys Phe Pro Glu Arg 
145                 150                 155                 160 
Asn Arg Val Leu Ser Arg Trp Arg Val Phe Ala Gly Ala Val Ala Gln 
                165                 170                 175     
Ala Ser Pro His Gly Leu Gln Leu Gly Val Gln Ala Val Val Tyr His 
            180                 185                 190         
Gly Gly Tyr Leu Pro Phe Arg Asp Pro Asn Ser Glu Glu Asn Ser Asn 
        195                 200                 205             
Asp Ile Ala Leu Val His Leu Ser Ser Pro Leu Pro Leu Thr Glu Tyr 
    210                 215                 220                 
Ile Gln Pro Val Cys Leu Pro Ala Ala Gly Gln Ala Leu Val Asp Gly 
225                 230                 235                 240 
Lys Ile Cys Thr Val Thr Gly Trp Gly Asn Thr Gln Tyr Tyr Gly Gln 
                245                 250                 255     
Gln Ala Gly Val Leu Gln Glu Ala Arg Val Pro Ile Ile Ser Asn Asp 
            260                 265                 270         
Val Cys Asn Gly Ala Asp Phe Tyr Gly Asn Gln Ile Lys Pro Lys Met 
        275                 280                 285             
Phe Cys Ala Gly Tyr Pro Glu Gly Gly Ile Asp Ala Cys Gln Gly Asp 
    290                 295                 300                 
Ser Gly Gly Pro Phe Val Cys Glu Asp Ser Ile Ser Arg Thr Pro Arg 
305                 310                 315                 320 
Trp Arg Leu Cys Gly Ile Val Ser Trp Gly Thr Gly Cys Ala Leu Ala 
                325                 330                 335     
Gln Lys Pro Gly Val Tyr Thr Lys Val Ser Asp Phe Arg Glu Trp Ile 
            340                 345                 350         
Phe Gln Ala Ile Lys Thr His Ser Glu Ala Ser Gly Met Val Thr Gln 
        355                 360                 365             
Leu 
    

<210> 4
<211> 496
<212> PRT
<213> Homo sapiens

<400> 4
Met Asp Tyr Lys Asp Asp Asp Asp Lys Ser Ser Met Gly Ser Arg Thr 
1               5                   10                  15      
Ser Leu Tyr Lys Lys Ala Gly Ser Asp Tyr Asp Ile Pro Thr Thr Glu 
            20                  25                  30          
Asn Leu Tyr Phe Gln Ala Ser Leu Leu Gln Ser Asp Arg Val Leu Tyr 
        35                  40                  45              
Leu Val Gln Gly Glu Lys Lys Val Arg Ala Pro Leu Ser Gln Leu Tyr 
    50                  55                  60                  
Phe Cys Arg Tyr Cys Ser Glu Leu Arg Ser Leu Glu Cys Val Ser His 
65                  70                  75                  80  
Glu Val Asp Ser His Tyr Cys Pro Ser Cys Leu Glu Asn Met Pro Ser 
                85                  90                  95      
Ala Glu Ala Lys Leu Lys Lys Asn Arg Cys Ala Asn Cys Phe Asp Cys 
            100                 105                 110         
Pro Gly Cys Met His Thr Leu Ser Thr Arg Ala Thr Ser Ile Ser Thr 
        115                 120                 125             
Gln Leu Pro Asp Asp Pro Ala Lys Thr Thr Met Lys Lys Ala Tyr Tyr 
    130                 135                 140                 
Leu Ala Cys Gly Phe Cys Arg Trp Thr Ser Arg Asp Val Gly Met Ala 
145                 150                 155                 160 
Asp Lys Ser Val Ala Ser Gly Gly Trp Gln Glu Pro Glu Asn Pro His 
                165                 170                 175     
Thr Gln Arg Met Asn Lys Leu Ile Glu Tyr Tyr Gln Gln Leu Ala Gln 
            180                 185                 190         
Lys Glu Lys Val Glu Arg Asp Arg Lys Lys Leu Ala Arg Arg Arg Asn 
        195                 200                 205             
Tyr Met Pro Leu Ala Phe Ser Asp Lys Tyr Gly Leu Gly Thr Arg Leu 
    210                 215                 220                 
Gln Arg Pro Arg Ala Gly Ala Ser Ile Ser Thr Leu Ala Gly Leu Ser 
225                 230                 235                 240 
Leu Lys Glu Gly Glu Asp Gln Lys Glu Ile Lys Ile Glu Pro Ala Gln 
                245                 250                 255     
Ala Val Asp Glu Val Glu Pro Leu Pro Glu Asp Tyr Tyr Thr Arg Pro 
            260                 265                 270         
Val Asn Leu Thr Glu Val Thr Thr Leu Gln Gln Arg Leu Leu Gln Pro 
        275                 280                 285             
Asp Phe Gln Pro Val Cys Ala Ser Gln Leu Tyr Pro Arg His Lys His 
    290                 295                 300                 
Leu Leu Ile Lys Arg Ser Leu Arg Cys Arg Lys Cys Glu His Asn Leu 
305                 310                 315                 320 
Ser Lys Pro Glu Phe Asn Pro Thr Ser Ile Lys Phe Lys Ile Gln Leu 
                325                 330                 335     
Val Ala Val Asn Tyr Ile Pro Glu Val Arg Ile Met Ser Ile Pro Asn 
            340                 345                 350         
Leu Arg Tyr Met Lys Glu Ser Gln Val Leu Leu Thr Leu Thr Asn Pro 
        355                 360                 365             
Val Glu Asn Leu Thr His Val Thr Leu Phe Glu Cys Glu Glu Gly Asp 
    370                 375                 380                 
Pro Asp Asp Ile Asn Ser Thr Ala Lys Val Val Val Pro Pro Lys Glu 
385                 390                 395                 400 
Leu Val Leu Ala Gly Lys Asp Ala Ala Ala Glu Tyr Asp Glu Leu Ala 
                405                 410                 415     
Glu Pro Gln Asp Phe Gln Asp Asp Pro Asp Ile Ile Ala Phe Arg Lys 
            420                 425                 430         
Ala Asn Lys Val Gly Ile Phe Ile Lys Val Thr Pro Gln Arg Glu Glu 
        435                 440                 445             
Gly Glu Val Thr Val Cys Phe Lys Met Lys His Asp Phe Lys Asn Leu 
    450                 455                 460                 
Ala Ala Pro Ile Arg Pro Ile Glu Glu Ser Asp Gln Gly Thr Glu Val 
465                 470                 475                 480 
Ile Trp Leu Thr Gln His Val Glu Leu Ser Leu Gly Pro Leu Leu Pro 
                485                 490                 495     



<210> 5
<211> 8
<212> PRT
<213> Homo sapiens

<400> 5
Gln Arg Pro Arg Ala Gly Ala Ser 
1               5               

<210> 6
<211> 12
<212> PRT
<213> Homo sapiens

<400> 6
Leu Gln Arg Pro Arg Ala Gly Ala Ser Ile Ser Thr 
1               5                   10          

<210> 7
<211> 8
<212> PRT
<213> Homo sapiens

<400> 7
Arg Met Arg Arg Tyr Ala Asp Ala 
1               5               

<210> 8
<211> 10
<212> PRT
<213> Homo sapiens

<400> 8
Leu Thr Ala Pro Arg Ser Leu Arg Arg Ser 
1               5                   10  

<210> 9
<211> 8
<212> PRT
<213> Homo sapiens

<400> 9
Ala Arg Arg His Ser Asp Gly Thr 
1               5               

<210> 10
<211> 8
<212> PRT
<213> Homo sapiens

<400> 10
Ala Ala Thr Arg Arg Gln Ala Val 
1               5               

<210> 11
<211> 8
<212> PRT
<213> Homo sapiens

<400> 11
Gln Leu Gln Lys Arg Phe Gly Gly 
1               5               

<210> 12
<211> 8
<212> PRT
<213> Homo sapiens

<400> 12
Arg Gln Arg Tyr Gly Lys Arg Ser 
1               5               

<210> 13
<211> 8
<212> PRT
<213> Homo sapiens

<400> 13
Leu Arg Asn Arg Ala Gln Ser Gly 
1               5               

<210> 14
<211> 46
<212> RNA
<213> Homo sapiens

<400> 14
gcaatggcgc tgacttctat gcgaacatag aagtcagcgc cattgc                    46


<210> 15
<211> 46
<212> RNA
<213> Homo sapiens

<400> 15
ggcgctgact tctatggaaa ccgaagtttc catagaagtc agcgcc                    46


<210> 16
<211> 46
<212> RNA
<213> Homo sapiens

<400> 16
gcgctgactt ctatggaaac ccgaaggttt ccatagaagt cagcgc                    46


<210> 17
<211> 47
<212> RNA
<213> Homo sapiens

<400> 17
ttctccgaac gtgtcacgtt tcaagagaac gtgacacgtt cggagaa                   47


<210> 18
<211> 19
<212> RNA
<213> Homo sapiens

<400> 18
caauggcgcu gacuucuau                                                 19


<210> 19
<211> 19
<212> RNA
<213> Homo sapiens

<400> 19
cuuacgcuga guacuucga                                                 19


<210> 20
<211> 19
<212> DNA
<213> Homo sapiens

<400> 20
cattgtggct gttctccta                                                 19


<210> 21
<211> 19
<212> DNA
<213> Homo sapiens

<400> 21
cagctcggag tgggtcagt                                                 19


<210> 22
<211> 26
<212> DNA
<213> Homo sapiens

<400> 22
tgacatggcg cagaaggagg tgcagg                                         26


