               SEQUENCE LISTING

<110> Université de Liège

<120> Osteomodulin and osteomodulin fragments as biomarkers for osteoarthritis and use thereof

<130> 2016-07

<160> 9

<170> BiSSAP 1.3

<210> 1
<211> 421
<212> PRT
<213> Homo sapiens

<220> 
<223> Osteomodulin

<400> 1
Met Gly Phe Leu Ser Pro Ile Tyr Val Ile Phe Phe Phe Phe Gly Val 
1               5                   10                  15      
Lys Val His Cys Gln Tyr Glu Thr Tyr Gln Trp Asp Glu Asp Tyr Asp 
            20                  25                  30          
Gln Glu Pro Asp Asp Asp Tyr Gln Thr Gly Phe Pro Phe Arg Gln Asn 
        35                  40                  45              
Val Asp Tyr Gly Val Pro Phe His Gln Tyr Thr Leu Gly Cys Val Ser 
    50                  55                  60                  
Glu Cys Phe Cys Pro Thr Asn Phe Pro Ser Ser Met Tyr Cys Asp Asn 
65                  70                  75                  80  
Arg Lys Leu Lys Thr Ile Pro Asn Ile Pro Met His Ile Gln Gln Leu 
                85                  90                  95      
Tyr Leu Gln Phe Asn Glu Ile Glu Ala Val Thr Ala Asn Ser Phe Ile 
            100                 105                 110         
Asn Ala Thr His Leu Lys Glu Ile Asn Leu Ser His Asn Lys Ile Lys 
        115                 120                 125             
Ser Gln Lys Ile Asp Tyr Gly Val Phe Ala Lys Leu Pro Asn Leu Leu 
    130                 135                 140                 
Gln Leu His Leu Glu His Asn Asn Leu Glu Glu Phe Pro Phe Pro Leu 
145                 150                 155                 160 
Pro Lys Ser Leu Glu Arg Leu Leu Leu Gly Tyr Asn Glu Ile Ser Lys 
                165                 170                 175     
Leu Gln Thr Asn Ala Met Asp Gly Leu Val Asn Leu Thr Met Leu Asp 
            180                 185                 190         
Leu Cys Tyr Asn Tyr Leu His Asp Ser Leu Leu Lys Asp Lys Ile Phe 
        195                 200                 205             
Ala Lys Met Glu Lys Leu Met Gln Leu Asn Leu Cys Ser Asn Arg Leu 
    210                 215                 220                 
Glu Ser Met Pro Pro Gly Leu Pro Ser Ser Leu Met Tyr Leu Ser Leu 
225                 230                 235                 240 
Glu Asn Asn Ser Ile Ser Ser Ile Pro Glu Lys Tyr Phe Asp Lys Leu 
                245                 250                 255     
Pro Lys Leu His Thr Leu Arg Met Ser His Asn Lys Leu Gln Asp Ile 
            260                 265                 270         
Pro Tyr Asn Ile Phe Asn Leu Pro Asn Ile Val Glu Leu Ser Val Gly 
        275                 280                 285             
His Asn Lys Leu Lys Gln Ala Phe Tyr Ile Pro Arg Asn Leu Glu His 
    290                 295                 300                 
Leu Tyr Leu Gln Asn Asn Glu Ile Glu Lys Met Asn Leu Thr Val Met 
305                 310                 315                 320 
Cys Pro Ser Ile Asp Pro Leu His Tyr His His Leu Thr Tyr Ile Arg 
                325                 330                 335     
Val Asp Gln Asn Lys Leu Lys Glu Pro Ile Ser Ser Tyr Ile Phe Phe 
            340                 345                 350         
Cys Phe Pro His Ile His Thr Ile Tyr Tyr Gly Glu Gln Arg Ser Thr 
        355                 360                 365             
Asn Gly Gln Thr Ile Gln Leu Lys Thr Gln Val Phe Arg Arg Phe Pro 
    370                 375                 380                 
Asp Asp Asp Asp Glu Ser Glu Asp His Asp Asp Pro Asp Asn Ala His 
385                 390                 395                 400 
Glu Ser Pro Glu Gln Glu Gly Ala Glu Gly His Phe Asp Leu His Tyr 
                405                 410                 415     
Tyr Glu Asn Gln Glu 
            420     

<210> 2
<211> 93
<212> PRT
<213> Homo sapiens

<220> 
<223> synthetic peptide

<400> 2
Lys Ile Asp Tyr Gly Val Phe Ala Lys Leu Pro Asn Leu Leu Gln Leu 
1               5                   10                  15      
His Leu Glu His Asn Asn Leu Glu Glu Phe Pro Phe Pro Leu Pro Lys 
            20                  25                  30          
Ser Leu Glu Arg Leu Leu Leu Gly Tyr Asn Glu Ile Ser Lys Leu Gln 
        35                  40                  45              
Thr Asn Ala Met Asp Gly Leu Val Asn Leu Thr Met Leu Asp Leu Cys 
    50                  55                  60                  
Tyr Asn Tyr Leu His Asp Ser Leu Leu Lys Asp Lys Ile Phe Ala Lys 
65                  70                  75                  80  
Met Glu Lys Leu Met Gln Leu Asn Leu Cys Ser Asn Arg 
                85                  90              

<210> 3
<211> 61
<212> PRT
<213> Homo sapiens

<220> 
<223> synthetic peptide

<400> 3
Met Tyr Leu Ser Leu Glu Asn Asn Ser Ile Ser Ser Ile Pro Glu Lys 
1               5                   10                  15      
Tyr Phe Asp Lys Leu Pro Lys Leu His Thr Leu Arg Met Ser His Asn 
            20                  25                  30          
Lys Leu Gln Asp Ile Pro Tyr Asn Ile Phe Asn Leu Pro Asn Ile Val 
        35                  40                  45              
Glu Leu Ser Val Gly His Asn Lys Leu Lys Gln Ala Phe 
    50                  55                  60      

<210> 4
<211> 15
<212> PRT
<213> Homo sapiens

<220> 
<223> synthetic peptide

<400> 4
Leu Glu His Asn Asn Leu Glu Glu Phe Pro Phe Pro Leu Pro Lys 
1               5                   10                  15  

<210> 5
<211> 15
<212> PRT
<213> Homo sapiens

<220> 
<223> synthetic peptide

<400> 5
Leu Arg Met Ser His Asn Lys Leu Gln Asp Ile Pro Tyr Asn Ile 
1               5                   10                  15  

<210> 6
<211> 21
<212> DNA
<213> Homo sapiens

<220> 
<223> primer

<400> 6
tgtaatgacc agtcaacagg g                                              21


<210> 7
<211> 18
<212> DNA
<213> Homo sapiens

<220> 
<223> primer

<400> 7
tgcctgacca aggaaagc                                                  18


<210> 8
<211> 22
<212> DNA
<213> Homo sapiens

<220> 
<223> primer

<400> 8
tcctggtttg ccttcttcac tt                                             22


<210> 9
<211> 23
<212> DNA
<213> Homo sapiens

<220> 
<223> primer

<400> 9
gggtcaatag aaggacacat cac                                            23


