                         SEQUENCE LISTING

<110>  Kansas State University Research Foundation
       Zhang, Weiping
 
<120>  ADHESIN TIP MULTIEPITOPE FUSION ANTIGEN PLATFORM AND VACCINES AND
        THEIR USE IN THE TREATMENT OF ENTEROTOXIGENIC DIARRHEA

<130>  40412-PCT

<150>  US 62/310,417
<151>  2016-03-18

<160>  121   

<170>  PatentIn version 3.5

<210>  1
<211>  361
<212>  PRT
<213>  Escherichia coli

<400>  1

Met Asn Lys Ile Leu Phe Ile Phe Thr Leu Phe Phe Ser Ser Gly Phe 
1               5                   10                  15      


Phe Thr Phe Ala Val Ser Ala Asp Lys Asn Asp Ile Gly Arg Leu Gln 
            20                  25                  30          


Ser Asp Ala Glu Tyr Pro His Asp Arg Asn Ile Thr Leu Asp Lys Asn 
        35                  40                  45              


Ala Gly Asn Thr Ser Tyr Leu Thr Ala Tyr Asn Gly Gln Phe Thr Glu 
    50                  55                  60                  


Lys Arg Ser Leu Ile Lys Arg Cys Leu Ser Ser Gln Asn Thr Leu Asn 
65                  70                  75                  80  


Gly Ala Cys Pro Ser Ser Asp Ala Pro Gly Thr Ala Thr Ile Asp Gly 
                85                  90                  95      


Glu Thr Asn Ile Thr Leu Gln Phe Thr Glu Lys Arg Ser Leu Ile Lys 
            100                 105                 110         


Arg Glu Leu Gln Ile Lys Gly Tyr Lys Gln Phe Leu Phe Tyr Asp Ser 
        115                 120                 125             


Asp Pro Lys Leu Asp Ser Gln Asn Ser Ser His Phe Gln Cys Asn Arg 
    130                 135                 140                 


Glu Gln Ala Ser Gly Ala Thr Val Ala Met Lys Asp Ala Tyr Gln Arg 
145                 150                 155                 160 


Asp Gly Lys Tyr Pro Asp Phe Gly Gly Val Trp Asn Ala Val Glu Gly 
                165                 170                 175     


Glu Lys Ser Pro Arg Arg Gly Val Thr Thr Tyr Gly Thr Tyr Thr Ile 
            180                 185                 190         


Asn Ile Thr Val Asn Leu Thr Asp Lys Gly Asn Ile Gln Ile Trp Leu 
        195                 200                 205             


Pro Gln Phe Lys Ser Asn Ala Arg Val Asp Leu Asn Leu Arg Pro Thr 
    210                 215                 220                 


Gly Gly Gly Thr Tyr Ile Gly Arg Asn Ser Val Asp Met Cys Phe Tyr 
225                 230                 235                 240 


Leu Arg Lys Ile Asn Asp Asp Thr Lys Leu Glu Ile Arg Phe Gln Asp 
                245                 250                 255     


Asp Asn Ser Lys Ser Asp Gly Lys Phe Tyr Leu Lys Lys Ile Asn Asp 
            260                 265                 270         


Asp Ser Lys Glu Leu Val Tyr Thr Leu Ser Leu Leu Leu Ala Gly Ser 
        275                 280                 285             


Gln Ser Ile Glu Met Arg Phe Gln Asp Asp Ser Gln Ile Asn Thr Ala 
    290                 295                 300                 


Ser Leu Glu Thr Asn Trp Asn Arg Ile Thr Ala Val Thr Met Pro Glu 
305                 310                 315                 320 


Ile Ser Val Pro Val Leu Cys Trp Pro Gly Arg Leu Gln Leu Asp Ala 
                325                 330                 335     


Lys Val Lys Asn Pro Glu Ala Gly Gln Tyr Met Gly Asn Ile Lys Ile 
            340                 345                 350         


Thr Phe Thr Pro Ser Ser Gln Thr Leu 
        355                 360     


<210>  2
<211>  400
<212>  PRT
<213>  Escherichia coli


<220>
<221>  MISC_FEATURE
<222>  (35)..(45)
<223>  Epitope

<400>  2

Met Asn Arg Ile Tyr Lys Leu Lys Phe Asp Lys Arg Arg Asn Glu Leu 
1               5                   10                  15      


Val Val Val Ser Glu Ile Thr Thr Gly Val Gly Asn Ala Lys Ala Thr 
            20                  25                  30          


Gly Ser Val Glu Gly Glu Lys Ser Pro Arg Arg Gly Val Arg Ala Met 
        35                  40                  45              


Ala Leu Ser Leu Leu Ser Gly Met Met Ile Met Ala His Pro Ala Met 
    50                  55                  60                  


Ser Ala Asn Leu Pro Thr Gly Gly Gln Ile Val Ala Gly Ser Gly Ser 
65                  70                  75                  80  


Ile Gln Thr Pro Ser Gly Asn Gln Met Asn Ile His Gln Asn Ser Gln 
                85                  90                  95      


Asn Met Val Ala Asn Trp Asn Ser Phe Asp Ile Gly Lys Gly Asn Thr 
            100                 105                 110         


Val Gln Phe Asp Gln Pro Ser Ser Ser Ala Val Ala Leu Asn Arg Val 
        115                 120                 125             


Val Gly Gly Gly Glu Ser Gln Ile Met Gly Asn Leu Lys Ala Asn Gly 
    130                 135                 140                 


Gln Val Phe Leu Val Asn Pro Asn Gly Val Leu Phe Gly Glu Gly Ala 
145                 150                 155                 160 


Ser Val Ser Thr Ser Gly Phe Val Ala Ser Thr Arg Asp Ile Lys Asn 
                165                 170                 175     


Asp Asp Phe Met Asn Arg Arg Tyr Thr Phe Ser Gly Gly Gln Lys Ala 
            180                 185                 190         


Gly Ala Ala Ile Val Asn Gln Gly Glu Leu Thr Thr Asn Ala Gly Gly 
        195                 200                 205             


Tyr Ile Val Leu Ala Ala Asp Arg Val Ser Asn Ser Gly Thr Ile Arg 
    210                 215                 220                 


Thr Pro Gly Gly Lys Thr Val Leu Ala Ala Ser Glu Arg Ile Thr Leu 
225                 230                 235                 240 


Gln Leu Asp Asn Gly Gly Leu Met Ser Val Gln Val Thr Gly Asp Val 
                245                 250                 255     


Val Asn Ala Leu Val Glu Asn Arg Gly Leu Val Ser Ala Arg Asp Gly 
            260                 265                 270         


Gln Val Tyr Leu Thr Ala Leu Gly Arg Gly Met Leu Met Asn Thr Val 
        275                 280                 285             


Leu Asn Val Ser Gly Val Val Glu Ala Ser Gly Met His Arg Gln Asp 
    290                 295                 300                 


Gly Asn Ile Val Leu Asp Gly Gly Asp Ser Gly Val Val His Leu Ser 
305                 310                 315                 320 


Gly Thr Leu Gln Ala Asp Asn Ala Ser Gly Gln Gly Gly Lys Val Val 
                325                 330                 335     


Val Gln Gly Lys Asn Ile Leu Leu Asp Lys Gly Ser Asn Ile Thr Ala 
            340                 345                 350         


Thr Gly Gly Gln Gly Gly Gly Glu Val Tyr Val Gly Gly Gly Trp Gln 
        355                 360                 365             


Gly Lys Asp Ser Asn Ile Arg Asn Ala Asp Lys Val Val Met Gln Gly 
    370                 375                 380                 


Gly Ala Arg Ile Asp Val Ser Ala Thr Gln Gln Gly Asn Gly Gly Thr 
385                 390                 395                 400 


<210>  3
<211>  31
<212>  DNA
<213>  Escherichia coli


<220>
<221>  misc_feature
<222>  (4)..(9)
<223>  Restriction Site

<400>  3
ctagctagcg ggcgataccc ggaaactaca g                                      31


<210>  4
<211>  29
<212>  DNA
<213>  Escherichia coli


<220>
<221>  misc_feature
<222>  (4)..(9)
<223>  Restricted Site

<400>  4
gatcggccgt cataaatttt cgacactgg                                         29


<210>  5
<211>  31
<212>  DNA
<213>  Escherichia coli


<220>
<221>  misc_feature
<222>  (4)..(9)
<223>  Restricted Site

<400>  5
ctagctagcc aatcatggca tacgaacgta g                                      31


<210>  6
<211>  32
<212>  DNA
<213>  Escherichia coli


<220>
<221>  misc_feature
<222>  (4)..(9)
<223>  Restriction Site

<400>  6
gatcggccgt tacagacttg aactactagg ag                                     32


<210>  7
<211>  47
<212>  DNA
<213>  Escherichia coli


<220>
<221>  misc_feature
<222>  (9)..(14)
<223>  Restriction Site

<400>  7
agttacatcc atgggcactc taaccaaaga actggcatta aatgtgc                     47


<210>  8
<211>  44
<212>  DNA
<213>  Escherichia coli


<220>
<221>  misc_feature
<222>  (9)..(14)
<223>  Restriction Site

<400>  8
tacatgatcg gccgttaatt acctgaaact aaatgttcgt tacc                        44


<210>  9
<211>  32
<212>  DNA
<213>  Escherichia coli


<220>
<221>  misc_feature
<222>  (4)..(9)
<223>  Restriction Site

<400>  9
ctagctagcg ataaaattcc cggagatgaa ag                                     32


<210>  10
<211>  34
<212>  DNA
<213>  Escherichia coli


<220>
<221>  misc_feature
<222>  (4)..(9)
<223>  Restriction Site

<400>  10
gatcggccgc tagagtgttt gactacttgg tgtg                                   34


<210>  11
<211>  30
<212>  DNA
<213>  Escherichia coli


<220>
<221>  misc_feature
<222>  (5)..(10)
<223>  Restriction Site

<400>  11
ttttccatgg ttatggttca ggctgctaca                                        30


<210>  12
<211>  30
<212>  DNA
<213>  Escherichia coli


<220>
<221>  misc_feature
<222>  (5)..(10)
<223>  Restriction Site

<400>  12
agatcggccg ttatttattg taacatttcc                                        30


<210>  13
<211>  44
<212>  DNA
<213>  Escherichia coli


<220>
<221>  misc_feature
<222>  (9)..(14)
<223>  Restriction Site

<400>  13
agttacatcc atgggctggc aatataaatc tctggatgta aatg                        44


<210>  14
<211>  45
<212>  DNA
<213>  Escherichia coli


<220>
<221>  misc_feature
<222>  (9)..(14)
<223>  Restriction Site

<400>  14
atgtagatcg gccgttaagt caaatttcct gcataagtac cagac                       45


<210>  15
<211>  34
<212>  DNA
<213>  Escherichia coli


<220>
<221>  misc_feature
<222>  (4)..(9)
<223>  Restriction Site

<400>  15
ctagctagca tgagcctgct ggaagttatc attg                                   34


<210>  16
<211>  32
<212>  DNA
<213>  Escherichia coli


<220>
<221>  misc_feature
<222>  (4)..(9)
<223>  Restriction Site

<400>  16
gatcggccgt taacggctac ctaaagtaat tg                                     32


<210>  17
<211>  33
<212>  DNA
<213>  Escherichia coli


<220>
<221>  misc_feature
<222>  (4)..(9)
<223>  Restriction Site

<400>  17
ctagctagcg gcgtgggtaa tgcaaaagcc acg                                    33


<210>  18
<211>  28
<212>  DNA
<213>  Escherichia coli


<220>
<221>  misc_feature
<222>  (4)..(9)
<223>  Restriction Site

<400>  18
ctagctagcg ataaaaatcc cggaagtg                                          28


<210>  19
<211>  29
<212>  DNA
<213>  Escherichia coli


<220>
<221>  misc_feature
<222>  (4)..(9)
<223>  Restriction Site

<400>  19
gatcggccgc tagagtgttt gactacttg                                         29


<210>  20
<211>  386
<212>  PRT
<213>  Escherichia coli


<220>
<221>  MISC_FEATURE
<222>  (24)..(39)
<223>  Epitopes

<220>
<221>  MISC_FEATURE
<222>  (91)..(106)
<223>  Epitope

<220>
<221>  MISC_FEATURE
<222>  (149)..(158)
<223>  Epitope

<220>
<221>  MISC_FEATURE
<222>  (231)..(243)
<223>  Epitope

<220>
<221>  MISC_FEATURE
<222>  (268)..(277)
<223>  Epitope

<220>
<221>  MISC_FEATURE
<222>  (303)..(316)
<223>  Epitope

<220>
<221>  MISC_FEATURE
<222>  (355)..(370)
<223>  Epitope

<400>  20

Met Asn Lys Ile Leu Phe Ile Phe Thr Leu Phe Phe Ser Ser Val Leu 
1               5                   10                  15      


Phe Thr Phe Ala Val Ser Ala Gln Glu Gly Ser Ser Asn Arg Ala Lys 
            20                  25                  30          


Ile Asp Gln Thr Gly Asp Tyr Thr Asn Ile Phe Gly Pro Arg Asp Arg 
        35                  40                  45              


Asn Glu Ser Ser Pro Lys His Asn Ile Leu Asn Asp Tyr Ile Thr Ala 
    50                  55                  60                  


Tyr Ser Glu Ser His Thr Leu Tyr Asp Arg Met Ile Phe Leu Cys Leu 
65                  70                  75                  80  


Ser Ser Gln Asn Thr Leu Asn Gly Ala Cys Pro Thr Ser Glu Asn Pro 
                85                  90                  95      


Ser Ser Ser Ser Val Ser Gly Glu Thr Asn Ile Thr Leu Gln Phe Thr 
            100                 105                 110         


Glu Lys Arg Ser Leu Ile Lys Arg Glu Leu Gln Ile Lys Gly Tyr Lys 
        115                 120                 125             


Arg Leu Leu Phe Lys Gly Ala Asn Cys Pro Ser Tyr Leu Thr Leu Asn 
    130                 135                 140                 


Ser Ala His Tyr Asn Lys Asp Gly Glu Gly Val Ser Pro Gly Gly Ala 
145                 150                 155                 160 


Ser Leu Tyr Leu Tyr Ile Pro Ala Gly Glu Leu Lys Asn Leu Pro Phe 
                165                 170                 175     


Gly Gly Ile Trp Asp Ala Thr Leu Lys Leu Arg Val Lys Arg Arg Tyr 
            180                 185                 190         


Asp Gln Thr Tyr Gly Thr Tyr Thr Ile Asn Ile Thr Val Lys Leu Thr 
        195                 200                 205             


Asp Lys Gly Asn Ile Gln Ile Trp Leu Pro Gln Phe Lys Ser Asp Ala 
    210                 215                 220                 


Arg Val Asp Leu Asn Leu Ser Phe Gln Ala Pro Arg Gln Asp Arg Ser 
225                 230                 235                 240 


Val Gln Ser Gly Arg Asn Ser Val Asp Met Cys Phe Tyr Asp Gly Tyr 
                245                 250                 255     


Ser Thr Asn Ser Ser Ser Leu Glu Leu Arg Phe Gln Asp Asn Asn Pro 
            260                 265                 270         


Lys Ser Asp Gly Lys Phe Tyr Leu Arg Lys Ile Asn Asp Asp Thr Lys 
        275                 280                 285             


Glu Ile Ala Tyr Thr Leu Ser Leu Leu Leu Ala Gly Lys Ser Ala Gly 
    290                 295                 300                 


Asn Lys Lys Pro Ile Trp Glu Asn Gln Ser Cys Asp Asn Ile Ala Asp 
305                 310                 315                 320 


Ala Ala Ser Leu Glu Ile Asn Trp Asn Arg Ile Thr Ala Val Thr Met 
                325                 330                 335     


Pro Glu Ile Ser Val Pro Val Leu Cys Trp Pro Gly Arg Leu Gln Leu 
            340                 345                 350         


Asp Ala Lys Lys Ser Pro Asp Ile Glu Asp Tyr Gln Glu Arg Pro Ala 
        355                 360                 365             


Asn Gly Tyr Met Gly Asn Ile Asn Ile Thr Phe Thr Pro Ser Ser Gln 
    370                 375                 380                 


Thr Leu 
385     


<210>  21
<211>  361
<212>  PRT
<213>  Escherichia coli


<220>
<221>  MISC_FEATURE
<222>  (23)..(33)
<223>  Epitope

<220>
<221>  MISC_FEATURE
<222>  (84)..(99)
<223>  Epitope

<220>
<221>  MISC_FEATURE
<222>  (141)..(150)
<223>  Epitope

<220>
<221>  MISC_FEATURE
<222>  (221)..(231)
<223>  Epitope

<220>
<221>  MISC_FEATURE
<222>  (255)..(264)
<223>  Epitope

<220>
<221>  MISC_FEATURE
<222>  (289)..(299)
<223>  Epitope

<220>
<221>  MISC_FEATURE
<222>  (336)..(346)
<223>  Epitope

<400>  21

Met Asn Lys Ile Leu Phe Ile Phe Thr Leu Phe Phe Ser Ser Val Leu 
1               5                   10                  15      


Phe Thr Phe Ala Val Ser Ala Asp Lys Ile Pro Gly Asp Glu Asn Ile 
            20                  25                  30          


Thr Asn Ile Phe Gly Pro Arg Asp Arg Asn Glu Ser Ser Pro Lys His 
        35                  40                  45              


Asn Ile Leu Asn Asp Tyr Ile Thr Ala Tyr Ser Glu Ser His Thr Leu 
    50                  55                  60                  


Tyr Asp Arg Met Ile Phe Leu Cys Leu Ser Ser Gln Asn Thr Leu Asn 
65                  70                  75                  80  


Gly Ala Cys Pro Thr Ser Glu Asn Pro Ser Ser Ser Ser Val Ser Gly 
                85                  90                  95      


Glu Thr Asn Ile Thr Leu Gln Phe Thr Glu Lys Arg Ser Leu Ile Lys 
            100                 105                 110         


Arg Glu Leu Gln Ile Lys Gly Tyr Lys Arg Leu Leu Phe Lys Gly Ala 
        115                 120                 125             


Asn Cys Pro Ser Tyr Leu Thr Leu Asn Ser Ala His Tyr Thr Cys Asn 
    130                 135                 140                 


Arg Asn Ser Ala Ser Gly Ala Ser Leu Tyr Leu Tyr Ile Pro Ala Gly 
145                 150                 155                 160 


Glu Leu Lys Asn Leu Pro Phe Gly Gly Ile Trp Asp Ala Thr Leu Lys 
                165                 170                 175     


Leu Arg Val Lys Arg Arg Tyr Asp Gln Thr Tyr Gly Thr Tyr Thr Ile 
            180                 185                 190         


Asn Ile Thr Val Lys Leu Thr Asp Lys Gly Asn Ile Gln Ile Trp Leu 
        195                 200                 205             


Pro Gln Phe Lys Ser Asp Ala Arg Val Asp Leu Asn Leu Arg Pro Thr 
    210                 215                 220                 


Gly Gly Gly Thr Tyr Ile Gly Arg Asn Ser Val Asp Met Cys Phe Tyr 
225                 230                 235                 240 


Asp Gly Tyr Ser Thr Asn Ser Ser Ser Leu Glu Leu Arg Phe Gln Asp 
                245                 250                 255     


Asn Asn Pro Lys Ser Asp Gly Lys Phe Tyr Leu Arg Lys Ile Asn Asp 
            260                 265                 270         


Asp Thr Lys Glu Ile Ala Tyr Thr Leu Ser Leu Leu Leu Ala Gly Lys 
        275                 280                 285             


Ser Leu Thr Pro Thr Asn Gly Thr Ser Leu Asn Ile Ala Asp Ala Ala 
    290                 295                 300                 


Ser Leu Glu Ile Asn Trp Asn Arg Ile Thr Ala Val Thr Met Pro Glu 
305                 310                 315                 320 


Ile Ser Val Pro Val Leu Cys Trp Pro Gly Arg Leu Gln Leu Asp Ala 
                325                 330                 335     


Lys Val Glu Asn Pro Glu Ala Gly Gln Tyr Met Gly Asn Ile Asn Ile 
            340                 345                 350         


Thr Phe Thr Pro Ser Ser Gln Thr Leu 
        355                 360     


<210>  22
<211>  16
<212>  PRT
<213>  Escherichia coli

<400>  22

Gln Glu Gly Ser Ser Asn Arg Ala Lys Ile Asp Gln Thr Gly Asp Tyr 
1               5                   10                  15      


<210>  23
<211>  16
<212>  PRT
<213>  Escherichia coli

<400>  23

Pro Thr Ser Glu Asn Pro Ser Ser Ser Ser Val Ser Gly Glu Thr Asn 
1               5                   10                  15      


<210>  24
<211>  10
<212>  PRT
<213>  Escherichia coli

<400>  24

Asn Lys Asp Gly Glu Gly Val Ser Pro Gly 
1               5                   10  


<210>  25
<211>  13
<212>  PRT
<213>  Escherichia coli

<400>  25

Ser Phe Gln Ala Pro Arg Gln Asp Arg Ser Val Gln Ser 
1               5                   10              


<210>  26
<211>  10
<212>  PRT
<213>  Escherichia coli

<400>  26

Gln Asp Asn Asn Pro Lys Ser Asp Gly Lys 
1               5                   10  


<210>  27
<211>  14
<212>  PRT
<213>  Escherichia coli

<400>  27

Ala Gly Asn Lys Lys Pro Ile Trp Glu Asn Gln Ser Cys Asp 
1               5                   10                  


<210>  28
<211>  16
<212>  PRT
<213>  Escherichia coli

<400>  28

Lys Lys Ser Pro Asp Ile Glu Asp Tyr Gln Glu Arg Pro Ala Asn Gly 
1               5                   10                  15      


<210>  29
<211>  151
<212>  PRT
<213>  Escherichia coli


<220>
<221>  MISC_FEATURE
<222>  (73)..(88)
<223>  Epitope

<400>  29

Met Lys Asn Lys Leu Leu Phe Met Met Leu Thr Ile Leu Gly Ala Pro 
1               5                   10                  15      


Gly Ile Ala Ala Ala Ala Gly Tyr Asp Leu Ala Asn Ser Glu Tyr Asn 
            20                  25                  30          


Phe Ala Val Asn Glu Leu Ser Lys Ser Ser Phe Asn Gln Ala Ala Ile 
        35                  40                  45              


Ile Gly Gln Ala Gly Thr Asn Asn Ser Ala Gln Leu Arg Gln Gly Gly 
    50                  55                  60                  


Ser Lys Leu Leu Ala Val Val Ala Gln Glu Gly Ser Ser Asn Arg Ala 
65                  70                  75                  80  


Lys Ile Asp Gln Thr Gly Asp Tyr Asn Leu Ala Tyr Ile Asp Gln Ala 
                85                  90                  95      


Gly Ser Ala Asn Asp Ala Ser Ile Ser Gln Gly Ala Tyr Gly Asn Thr 
            100                 105                 110         


Ala Met Ile Ile Gln Lys Gly Ser Gly Asn Lys Ala Asn Ile Thr Gln 
        115                 120                 125             


Tyr Gly Thr Gln Lys Thr Ala Ile Val Val Gln Arg Gln Ser Gln Met 
    130                 135                 140                 


Ala Ile Arg Val Thr Gln Arg 
145                 150     


<210>  30
<211>  177
<212>  PRT
<213>  Escherichia coli


<220>
<221>  MISC_FEATURE
<222>  (155)..(164)
<223>  Epitope

<400>  30

Met Leu Lys Arg Ile Ser Cys Ile Ile Phe Val Phe Phe Ser Gly Leu 
1               5                   10                  15      


Ile Tyr Ala Ala Glu Ile Thr Asn Gln Ile Glu Leu Ser Val Lys Val 
            20                  25                  30          


Asn Ile Ser Lys Pro Met Cys Lys Leu Asn Ser Gly Thr Gln Thr Ile 
        35                  40                  45              


Asp Phe Gly Asp Phe Asp Val Leu Asp Ile Ile Thr Glu Asn Arg Lys 
    50                  55                  60                  


Leu Asn Gly His Ala Thr Phe Lys Phe Thr Glu Cys Ser Ser Val Lys 
65                  70                  75                  80  


Asn Met Lys Ile Lys Phe Lys Gln Ala Gly Gln Asn Pro Ala Leu Asp 
                85                  90                  95      


Ile Val Asn Asn Tyr Ile Pro Asn Ser Lys Gly Asp Arg Met Ala Lys 
            100                 105                 110         


Gly Val Ala Val Lys Leu Leu Asp Asp Lys Lys Gln Glu Ile Gln Leu 
        115                 120                 125             


Asn Lys Glu Met Asn Val Ile Val Glu Glu Ser Leu Thr Phe Lys Asp 
    130                 135                 140                 


Leu Thr Leu Asn Ala Gln Val Ile Ser Ile Asn Lys Asp Gly Glu Gly 
145                 150                 155                 160 


Val Ser Pro Gly Leu Leu Gln Thr Ala Ile Gly Met Glu Ile Ser Tyr 
                165                 170                 175     


Glu 
    


<210>  31
<211>  363
<212>  PRT
<213>  Escherichia coli


<220>
<221>  MISC_FEATURE
<222>  (32)..(44)
<223>  Epitope

<400>  31

Met Lys Lys Ile Phe Ile Phe Leu Ser Ile Ile Phe Ser Ala Val Val 
1               5                   10                  15      


Ser Ala Gly Arg Tyr Pro Glu Thr Thr Val Gly Asn Leu Thr Lys Ser 
            20                  25                  30          


Phe Gln Ala Pro Arg Gln Asp Arg Ser Val Gln Ser Pro Ile Tyr Asn 
        35                  40                  45              


Ile Phe Thr Asn His Val Ala Gly Tyr Ser Leu Ser His Asn Leu Tyr 
    50                  55                  60                  


Asp Arg Ile Val Phe Leu Cys Thr Ser Ser Ser Asn Pro Val Asn Gly 
65                  70                  75                  80  


Ala Cys Pro Thr Leu Gly Thr Ser Gly Val Gln Tyr Gly Thr Thr Thr 
                85                  90                  95      


Ile Thr Leu Gln Phe Thr Glu Lys Arg Ser Leu Ile Lys Arg Asn Ile 
            100                 105                 110         


Asn Leu Ala Gly Asn Lys Lys Pro Ile Trp Glu Asn Gln Ser Cys Asp 
        115                 120                 125             


Thr Ser Asn Leu Met Val Leu Asn Ser Lys Ser Trp Ser Cys Gly His 
    130                 135                 140                 


Tyr Gly Asn Ala Asn Gly Thr Leu Leu Asn Leu Tyr Ile Pro Ala Gly 
145                 150                 155                 160 


Glu Ile Asn Lys Leu Pro Phe Gly Gly Ile Trp Glu Ala Thr Leu Ile 
                165                 170                 175     


Leu Arg Leu Ser Arg Tyr Gly Glu Val Ser Ser Thr His Tyr Gly Asn 
            180                 185                 190         


Tyr Thr Val Asn Ile Thr Val Asp Leu Thr Asp Lys Gly Asn Ile Gln 
        195                 200                 205             


Val Trp Leu Pro Gly Phe His Ser Asn Pro Arg Val Asp Leu Asn Leu 
    210                 215                 220                 


His Pro Ile Gly Asn Tyr Lys Tyr Ser Gly Ser Asn Ser Leu Asp Met 
225                 230                 235                 240 


Cys Phe Tyr Asp Gly Tyr Ser Thr Asn Ser Asp Ser Met Val Ile Lys 
                245                 250                 255     


Phe Gln Asp Asp Asn Pro Thr Tyr Ser Ser Glu Tyr Asn Leu Tyr Lys 
            260                 265                 270         


Ile Gly Gly Thr Glu Lys Leu Pro Tyr Ala Val Ser Leu Leu Met Gly 
        275                 280                 285             


Glu Lys Ile Phe Tyr Pro Val Asn Gly Gln Ser Phe Thr Ile Asn Asp 
    290                 295                 300                 


Ser Ser Val Leu Glu Thr Asn Trp Asn Arg Val Thr Ala Val Ala Met 
305                 310                 315                 320 


Pro Glu Val Asn Val Pro Val Leu Cys Trp Pro Ala Arg Leu Leu Leu 
                325                 330                 335     


Asn Ala Asp Val Asn Ala Pro Asp Ala Gly Gln Tyr Ser Gly Gln Ile 
            340                 345                 350         


Tyr Ile Thr Phe Thr Pro Ser Val Glu Asn Leu 
        355                 360             


<210>  32
<211>  363
<212>  PRT
<213>  Escherichia coli


<220>
<221>  MISC_FEATURE
<222>  (115)..(128)
<223>  Epitope

<400>  32

Met Lys Lys Ile Phe Ile Phe Leu Ser Ile Ile Phe Ser Ala Val Val 
1               5                   10                  15      


Ser Ala Gly Arg Tyr Pro Glu Thr Thr Val Gly Asn Leu Thr Lys Ser 
            20                  25                  30          


Phe Gln Ala Pro Arg Leu Asp Arg Ser Val Gln Ser Pro Ile Tyr Asn 
        35                  40                  45              


Ile Phe Thr Asn His Val Ala Gly Tyr Ser Leu Ser His Arg Leu Tyr 
    50                  55                  60                  


Asp Arg Ile Val Phe Val Cys Thr Ser Ser Ser Asn Pro Val Asn Gly 
65                  70                  75                  80  


Ala Cys Pro Thr Ile Gly Thr Ser Arg Val Glu Tyr Gly Thr Thr Thr 
                85                  90                  95      


Ile Thr Leu Gln Phe Thr Glu Lys Arg Ser Leu Ile Lys Arg Asn Ile 
            100                 105                 110         


Asn Leu Ala Gly Asn Lys Lys Pro Ile Trp Glu Asn Gln Ser Cys Asp 
        115                 120                 125             


Thr Ser Asn Leu Met Val Leu Asn Ser Lys Ser Trp Ser Cys Gly Ala 
    130                 135                 140                 


Leu Gly Asn Ala Asn Gly Thr Leu Leu Asn Leu Tyr Ile Pro Ala Gly 
145                 150                 155                 160 


Glu Ile Asn Lys Leu Pro Phe Gly Gly Ile Trp Glu Ala Thr Leu Ile 
                165                 170                 175     


Leu Arg Leu Ser Arg Tyr Gly Glu Val Ser Ser Thr His Tyr Gly Asn 
            180                 185                 190         


Tyr Thr Val Asn Ile Thr Val Asp Leu Thr Asp Lys Gly Asn Ile Gln 
        195                 200                 205             


Val Trp Leu Pro Gly Phe His Ser Asn Pro Arg Val Asp Leu Asn Leu 
    210                 215                 220                 


His Pro Ile Gly Asn Tyr Lys Tyr Ser Gly Ser Asn Ser Leu Asp Met 
225                 230                 235                 240 


Cys Phe Tyr Asp Gly Tyr Ser Thr Asn Ser Asp Ser Met Val Ile Lys 
                245                 250                 255     


Phe Gln Asp Asp Asn Pro Thr Asn Ser Ser Glu Tyr Asn Leu Tyr Lys 
            260                 265                 270         


Ile Gly Gly Thr Glu Lys Leu Pro Tyr Ala Val Ser Leu Leu Met Gly 
        275                 280                 285             


Gly Lys Ile Phe Tyr Pro Val Asn Gly Gln Ser Phe Thr Ile Asn Asp 
    290                 295                 300                 


Ser Ser Val Leu Glu Thr Asn Trp Asn Arg Val Thr Ala Val Ala Met 
305                 310                 315                 320 


Pro Glu Val Asn Val Pro Val Leu Cys Trp Pro Ala Arg Leu Leu Leu 
                325                 330                 335     


Asn Ala Asp Val Asn Ala Pro Asp Ala Gly Gln Tyr Ser Gly Gln Ile 
            340                 345                 350         


Tyr Ile Thr Phe Thr Pro Ser Val Glu Asn Leu 
        355                 360             


<210>  33
<211>  290
<212>  PRT
<213>  Escherichia coli


<220>
<221>  MISC_FEATURE
<222>  (222)..(237)
<223>  Epitope

<400>  33

Met Ser His Tyr Lys Thr Gly His Lys Gln Pro Arg Phe Arg Tyr Ser 
1               5                   10                  15      


Val Leu Ala Arg Cys Val Ala Trp Ala Asn Ile Ser Val Gln Val Leu 
            20                  25                  30          


Phe Pro Leu Ala Val Thr Phe Thr Pro Val Met Ala Ala Arg Ala Gln 
        35                  40                  45              


His Ala Val Gln Pro Arg Leu Ser Met Gly Asn Thr Thr Val Thr Ala 
    50                  55                  60                  


Asp Asn Asn Val Glu Lys Asn Val Ala Ser Phe Ala Ala Asn Ala Gly 
65                  70                  75                  80  


Thr Phe Leu Ser Ser Gln Pro Asp Ser Asp Ala Thr Arg Asn Phe Ile 
                85                  90                  95      


Thr Gly Met Ala Thr Ala Lys Ala Asn Gln Glu Ile Gln Glu Trp Leu 
            100                 105                 110         


Gly Lys Tyr Gly Thr Ala Arg Val Lys Leu Asn Val Asp Lys Asp Phe 
        115                 120                 125             


Ser Leu Lys Asp Ser Ser Leu Glu Met Leu Tyr Pro Ile Tyr Asp Thr 
    130                 135                 140                 


Pro Thr Asn Met Leu Phe Thr Gln Gly Ala Ile His Arg Thr Asp Asp 
145                 150                 155                 160 


Arg Thr Gln Ser Asn Ile Gly Phe Gly Trp Arg His Phe Ser Gly Asn 
                165                 170                 175     


Asp Trp Met Ala Gly Val Asn Thr Phe Ile Asp His Asp Leu Ser Arg 
            180                 185                 190         


Ser His Thr Arg Ile Gly Val Gly Ala Glu Tyr Trp Arg Asp Tyr Leu 
        195                 200                 205             


Lys Leu Ser Ala Asn Gly Tyr Ile Arg Ala Ser Gly Trp Lys Lys Ser 
    210                 215                 220                 


Pro Asp Ile Glu Asp Tyr Gln Glu Arg Pro Ala Asn Gly Trp Asp Ile 
225                 230                 235                 240 


Arg Ala Glu Gly Tyr Leu Pro Ala Trp Pro Gln Leu Gly Ala Ser Leu 
                245                 250                 255     


Met Tyr Glu Gln Tyr Tyr Gly Asp Glu Val Gly Leu Phe Gly Lys Asp 
            260                 265                 270         


Lys Arg Gln Lys Asp Pro His Ala Ile Ser Ala Glu Val Thr Tyr Thr 
        275                 280                 285             


Pro Val 
    290 


<210>  34
<211>  42
<212>  DNA
<213>  Escherichia coli


<220>
<221>  misc_feature
<222>  (9)..(14)
<223>  Restriction Site

<400>  34
atgtagatcg gccgttagct gaaggtgtaa cgacggttca tg                          42


<210>  35
<211>  11
<212>  PRT
<213>  Escherichia coli

<400>  35

Asp Ile Gly Arg Leu Gln Ser Asp Ala Glu Tyr 
1               5                   10      


<210>  36
<211>  10
<212>  PRT
<213>  Escherichia coli

<400>  36

Tyr Asp Ser Asp Pro Lys Leu Asp Ser Gln 
1               5                   10  


<210>  37
<211>  11
<212>  PRT
<213>  Escherichia coli

<400>  37

Gln Phe Thr Glu Lys Arg Ser Leu Ile Lys Arg 
1               5                   10      


<210>  38
<211>  10
<212>  PRT
<213>  Escherichia coli

<400>  38

Tyr Asp Ser Asp Pro Lys Leu Asp Ser Gln 
1               5                   10  


<210>  39
<211>  16
<212>  PRT
<213>  Escherichia coli

<400>  39

Val Ala Met Lys Asp Ala Tyr Gln Arg Asp Gly Lys Tyr Pro Asp Phe 
1               5                   10                  15      


<210>  40
<211>  11
<212>  PRT
<213>  Escherichia coli

<400>  40

Val Glu Gly Glu Lys Ser Pro Arg Arg Gly Val 
1               5                   10      


<210>  41
<211>  11
<212>  PRT
<213>  Escherichia coli

<400>  41

Phe Tyr Leu Arg Lys Ile Asn Asp Asp Thr Lys 
1               5                   10      


<210>  42
<211>  13
<212>  PRT
<213>  Escherichia coli

<400>  42

Ser Gln Ser Ile Glu Met Arg Phe Gln Asp Asp Ser Gln 
1               5                   10              


<210>  43
<211>  14
<212>  PRT
<213>  Escherichia coli

<400>  43

Thr Glu Lys Arg Ser Leu Ile Lys Arg Glu Leu Gln Ile Lys 
1               5                   10                  


<210>  44
<211>  22
<212>  PRT
<213>  Escherichia coli

<400>  44

Gln Asp Asp Asn Ser Lys Ser Asp Gly Lys Phe Tyr Leu Lys Lys Ile 
1               5                   10                  15      


Asn Asp Asp Ser Lys Glu 
            20          


<210>  45
<211>  13
<212>  PRT
<213>  Escherichia coli

<400>  45

Arg Leu Gln Leu Asp Ala Lys Val Lys Asn Pro Glu Ala 
1               5                   10              


<210>  46
<211>  360
<212>  PRT
<213>  Escherichia coli


<220>
<221>  MISC_FEATURE
<222>  (105)..(118)
<223>  Epitope

<220>
<221>  MISC_FEATURE
<222>  (255)..(276)
<223>  Epitope

<220>
<221>  MISC_FEATURE
<222>  (330)..(342)
<223>  Epitope

<400>  46

Met Asn Lys Ile Leu Phe Ile Phe Thr Leu Phe Phe Ser Ser Gly Phe 
1               5                   10                  15      


Phe Thr Phe Ala Val Ser Ala Asp Lys Asn Pro Gly Ser Glu Asn Met 
            20                  25                  30          


Thr Asn Thr Ile Gly Pro His Asp Arg Gly Gly Ser Ser Pro Ile Tyr 
        35                  40                  45              


Asn Ile Leu Asn Ser Tyr Leu Thr Ala Tyr Asn Gly Ser His His Leu 
    50                  55                  60                  


Tyr Asp Arg Met Ser Phe Leu Cys Leu Ser Ser Gln Asn Thr Leu Asn 
65                  70                  75                  80  


Gly Ala Cys Pro Ser Ser Asp Ala Pro Gly Thr Ala Thr Ile Asp Gly 
                85                  90                  95      


Glu Thr Asn Ile Thr Leu Gln Phe Thr Glu Lys Arg Ser Leu Ile Lys 
            100                 105                 110         


Arg Glu Leu Gln Ile Lys Gly Tyr Lys Gln Phe Leu Phe Lys Asn Ala 
        115                 120                 125             


Asn Cys Pro Ser Lys Leu Ala Leu Asn Ser Ser His Phe Gln Cys Asn 
    130                 135                 140                 


Arg Glu Gln Ala Ser Gly Ala Thr Leu Ser Leu Tyr Ile Pro Ala Gly 
145                 150                 155                 160 


Glu Leu Asn Lys Leu Pro Phe Gly Gly Val Trp Asn Ala Val Leu Lys 
                165                 170                 175     


Leu Asn Val Lys Arg Arg Tyr Asp Thr Thr Tyr Gly Thr Tyr Thr Ile 
            180                 185                 190         


Asn Ile Thr Val Asn Leu Thr Asp Lys Gly Asn Ile Gln Ile Trp Leu 
        195                 200                 205             


Pro Gln Phe Lys Ser Asn Ala Arg Val Asp Leu Asn Leu Arg Pro Thr 
    210                 215                 220                 


Gly Gly Gly Thr Tyr Ile Gly Arg Asn Ser Val Asp Met Cys Phe Tyr 
225                 230                 235                 240 


Asp Gly Tyr Ser Thr Asn Ser Ser Ser Leu Glu Ile Arg Phe Gln Asp 
                245                 250                 255     


Asp Asn Ser Lys Ser Asp Gly Lys Phe Tyr Leu Lys Lys Ile Asn Asp 
            260                 265                 270         


Asp Ser Lys Glu Leu Val Tyr Thr Leu Ser Leu Leu Leu Ala Gly Lys 
        275                 280                 285             


Asn Leu Thr Pro Thr Asn Gly Gln Ala Leu Asn Ile Asn Thr Ala Ser 
    290                 295                 300                 


Leu Glu Thr Asn Trp Asn Arg Ile Thr Ala Val Thr Met Pro Glu Ile 
305                 310                 315                 320 


Ser Val Pro Val Leu Cys Trp Pro Gly Arg Leu Gln Leu Asp Ala Lys 
                325                 330                 335     


Val Lys Asn Pro Glu Ala Gly Gln Tyr Met Gly Asn Ile Lys Ile Thr 
            340                 345                 350         


Phe Thr Pro Ser Ser Gln Thr Leu 
        355                 360 


<210>  47
<211>  363
<212>  PRT
<213>  Escherichia coli


<220>
<221>  MISC_FEATURE
<222>  (100)..(110)
<223>  Epitope

<400>  47

Met Lys Lys Ile Phe Ile Phe Leu Ser Ile Ile Phe Ser Ala Val Val 
1               5                   10                  15      


Ser Ala Gly Arg Tyr Pro Glu Thr Thr Val Gly Asn Leu Thr Lys Ser 
            20                  25                  30          


Phe Gln Ala Pro Arg Leu Asp Arg Ser Val Gln Ser Pro Ile Tyr Asn 
        35                  40                  45              


Ile Phe Thr Asn His Val Ala Gly Tyr Ser Leu Ser His Ser Leu Tyr 
    50                  55                  60                  


Asp Arg Ile Val Phe Leu Cys Thr Ser Ser Ser Asn Pro Val Asn Gly 
65                  70                  75                  80  


Ala Cys Pro Thr Ile Gly Thr Ser Gly Val Gln Tyr Gly Thr Thr Thr 
                85                  90                  95      


Ile Thr Leu Gln Phe Thr Glu Lys Arg Ser Leu Ile Lys Arg Asn Ile 
            100                 105                 110         


Asn Leu Ala Gly Asn Lys Lys Pro Ile Trp Glu Asn Gln Ser Cys Asp 
        115                 120                 125             


Phe Ser Asn Leu Met Val Leu Asn Ser Lys Ser Trp Ser Cys Gly Ala 
    130                 135                 140                 


His Gly Asn Ala Asn Gly Thr Leu Leu Asn Leu Tyr Ile Pro Ala Gly 
145                 150                 155                 160 


Glu Ile Asn Lys Leu Pro Phe Gly Gly Ile Trp Glu Ala Thr Leu Ile 
                165                 170                 175     


Leu Arg Leu Ser Arg Tyr Gly Glu Val Ser Ser Thr His Tyr Gly Asn 
            180                 185                 190         


Tyr Thr Val Asn Ile Thr Val Asp Leu Thr Asp Lys Gly Asn Ile Gln 
        195                 200                 205             


Val Trp Leu Pro Gly Phe His Ser Asn Pro Arg Val Asp Leu Asn Leu 
    210                 215                 220                 


Arg Pro Ile Gly Asn Tyr Lys Tyr Ser Gly Ser Asn Ser Leu Asp Met 
225                 230                 235                 240 


Cys Phe Tyr Asp Gly Tyr Ser Thr Asn Ser Asp Ser Met Val Ile Lys 
                245                 250                 255     


Phe Gln Asp Asp Asn Pro Thr Asn Ser Ser Glu Tyr Asn Leu Tyr Lys 
            260                 265                 270         


Ile Gly Gly Thr Glu Lys Leu Pro Tyr Ala Val Ser Leu Leu Met Gly 
        275                 280                 285             


Glu Lys Ile Phe Tyr Pro Val Asn Gly Gln Ser Phe Thr Ile Asn Asp 
    290                 295                 300                 


Ser Ser Val Leu Glu Thr Asn Trp Asn Arg Val Thr Ala Val Ala Met 
305                 310                 315                 320 


Pro Glu Val Asn Val Pro Val Leu Cys Trp Pro Ala Arg Leu Leu Leu 
                325                 330                 335     


Asn Ala Asp Val Asn Ala Pro Asp Ala Gly Gln Tyr Ser Gly Gln Ile 
            340                 345                 350         


Tyr Ile Thr Phe Thr Pro Ser Val Glu Asn Leu 
        355                 360             


<210>  48
<211>  364
<212>  PRT
<213>  Escherichia coli


<220>
<221>  MISC_FEATURE
<222>  (250)..(263)
<223>  Epitope

<400>  48

Met Lys Lys Val Ile Phe Val Leu Ser Met Phe Leu Cys Ser Gln Val 
1               5                   10                  15      


Tyr Gly Gln Ser Trp His Thr Asn Val Glu Ala Gly Ser Ile Asn Lys 
            20                  25                  30          


Thr Glu Ser Ile Gly Pro Ile Asp Arg Ser Ala Ala Ala Ser Tyr Pro 
        35                  40                  45              


Ala His Tyr Ile Phe His Glu His Val Ala Gly Tyr Asn Lys Asp His 
    50                  55                  60                  


Ser Leu Phe Asp Arg Met Thr Phe Leu Cys Met Ser Ser Thr Asp Ala 
65                  70                  75                  80  


Ser Lys Gly Ala Cys Pro Thr Gly Glu Asn Ser Lys Ser Ser Gln Gly 
                85                  90                  95      


Glu Thr Asn Ile Lys Leu Ile Phe Thr Glu Lys Lys Ser Leu Ala Arg 
            100                 105                 110         


Lys Thr Leu Asn Leu Lys Gly Tyr Lys Arg Phe Leu Tyr Glu Ser Asp 
        115                 120                 125             


Arg Cys Ile His Tyr Val Asp Lys Met Asn Leu Asn Ser His Thr Val 
    130                 135                 140                 


Lys Cys Val Gly Ser Phe Thr Arg Gly Val Asp Phe Thr Leu Tyr Ile 
145                 150                 155                 160 


Pro Gln Gly Glu Ile Asp Gly Leu Leu Thr Gly Gly Ile Trp Glu Ala 
                165                 170                 175     


Thr Leu Glu Leu Arg Val Lys Arg His Tyr Asp Tyr Asn His Gly Thr 
            180                 185                 190         


Tyr Lys Val Asn Ile Thr Val Asp Leu Thr Asp Lys Gly Asn Ile Gln 
        195                 200                 205             


Val Trp Thr Pro Lys Phe His Ser Asp Pro Arg Ile Asp Leu Asn Leu 
    210                 215                 220                 


Arg Pro Glu Gly Asn Gly Lys Tyr Ser Gly Ser Asn Val Leu Glu Met 
225                 230                 235                 240 


Cys Leu Tyr Asp Gly Tyr Ser Thr His Ser Gln Ser Ile Glu Met Arg 
                245                 250                 255     


Phe Gln Asp Asp Ser Gln Thr Gly Asn Asn Glu Tyr Asn Leu Ile Lys 
            260                 265                 270         


Thr Gly Glu Pro Leu Lys Lys Leu Pro Tyr Lys Leu Ser Leu Leu Leu 
        275                 280                 285             


Gly Gly Arg Glu Phe Tyr Pro Asn Asn Gly Glu Ala Phe Thr Ile Asn 
    290                 295                 300                 


Asp Thr Ser Ser Leu Phe Ile Asn Trp Asn Arg Ile Lys Ser Val Ser 
305                 310                 315                 320 


Leu Pro Gln Ile Ser Ile Pro Val Leu Cys Trp Pro Ala Asn Leu Thr 
                325                 330                 335     


Phe Met Ser Glu Leu Asn Asn Pro Glu Ala Gly Glu Tyr Ser Gly Ile 
            340                 345                 350         


Leu Asn Val Thr Phe Thr Pro Ser Ser Ser Ser Leu 
        355                 360                 


<210>  49
<211>  168
<212>  PRT
<213>  Escherichia coli


<220>
<221>  MISC_FEATURE
<222>  (115)..(125)
<223>  Epitope

<400>  49

Met Leu Lys Ile Lys Tyr Leu Leu Ile Gly Leu Ser Leu Ser Ala Met 
1               5                   10                  15      


Ser Ser Tyr Ser Leu Ala Ala Ala Gly Pro Thr Leu Thr Lys Glu Leu 
            20                  25                  30          


Ala Leu Asn Val Leu Ser Pro Ala Ala Leu Asp Ala Thr Trp Ala Pro 
        35                  40                  45              


Gln Asp Asn Leu Thr Leu Ser Asn Thr Gly Val Ser Asn Thr Leu Val 
    50                  55                  60                  


Gly Val Leu Thr Leu Ser Asn Thr Ser Ile Asp Thr Val Ser Ile Ala 
65                  70                  75                  80  


Ser Thr Asn Val Ser Asp Thr Ser Lys Asn Gly Thr Val Thr Phe Ala 
                85                  90                  95      


His Glu Thr Asn Asn Ser Ala Ser Phe Ala Thr Thr Ile Ser Thr Asp 
            100                 105                 110         


Asn Ala Asn Ile Thr Leu Asp Lys Asn Ala Gly Asn Thr Ile Val Lys 
        115                 120                 125             


Thr Thr Asn Gly Ser Gln Leu Pro Thr Asn Leu Pro Leu Lys Phe Ile 
    130                 135                 140                 


Thr Thr Glu Gly Asn Glu His Leu Val Ser Gly Asn Tyr Arg Ala Asn 
145                 150                 155                 160 


Ile Thr Ile Thr Ser Thr Ile Lys 
                165             


<210>  50
<211>  361
<212>  PRT
<213>  Escherichia coli


<220>
<221>  MISC_FEATURE
<222>  (265)..(275)
<223>  Epitope

<400>  50

Met Asn Lys Ile Leu Phe Ile Phe Thr Leu Phe Phe Ser Ser Val Leu 
1               5                   10                  15      


Phe Thr Phe Ala Val Ser Ala Asp Lys Ile Pro Gly Asp Glu Ser Ile 
            20                  25                  30          


Thr Asn Ile Phe Gly Pro Arg Asp Arg Asn Glu Ser Ser Pro Lys His 
        35                  40                  45              


Asn Ile Leu Asn Asn His Ile Thr Ala Tyr Ser Glu Ser His Thr Leu 
    50                  55                  60                  


Tyr Asp Arg Met Thr Phe Leu Cys Leu Ser Ser His Asn Thr Leu Asn 
65                  70                  75                  80  


Gly Ala Cys Pro Thr Ser Glu Asn Pro Ser Ser Ser Ser Val Ser Gly 
                85                  90                  95      


Glu Thr Asn Ile Thr Leu Gln Phe Thr Glu Lys Arg Ser Leu Ile Lys 
            100                 105                 110         


Arg Glu Leu Gln Ile Lys Gly Tyr Lys Gln Leu Leu Phe Lys Ser Val 
        115                 120                 125             


Asn Cys Pro Ser Gly Leu Thr Leu Asn Ser Ala His Phe Asn Cys Asn 
    130                 135                 140                 


Lys Asn Ala Ala Ser Gly Ala Ser Leu Tyr Leu Tyr Ile Pro Ala Gly 
145                 150                 155                 160 


Glu Leu Lys Asn Leu Pro Phe Gly Gly Ile Trp Asp Ala Thr Leu Lys 
                165                 170                 175     


Leu Arg Val Lys Arg Arg Tyr Ser Glu Thr Tyr Gly Thr Tyr Thr Ile 
            180                 185                 190         


Asn Ile Thr Ile Lys Leu Thr Asp Lys Gly Asn Ile Gln Ile Trp Leu 
        195                 200                 205             


Pro Gln Phe Lys Ser Asp Ala Arg Val Asp Leu Asn Leu Arg Pro Thr 
    210                 215                 220                 


Gly Gly Gly Thr Tyr Ile Gly Arg Asn Ser Val Asp Met Cys Phe Tyr 
225                 230                 235                 240 


Asp Gly Tyr Ser Thr Asn Ser Ser Ser Leu Glu Ile Arg Phe Gln Asp 
                245                 250                 255     


Asn Asn Pro Lys Ser Asp Gly Lys Phe Tyr Leu Arg Lys Ile Asn Asp 
            260                 265                 270         


Asp Thr Lys Glu Ile Ala Tyr Thr Leu Ser Leu Leu Leu Ala Gly Lys 
        275                 280                 285             


Ser Leu Thr Pro Thr Asn Gly Thr Ser Leu Asn Ile Ala Asp Ala Ala 
    290                 295                 300                 


Ser Leu Glu Thr Asn Trp Asn Arg Ile Thr Ala Val Thr Met Pro Glu 
305                 310                 315                 320 


Ile Ser Val Pro Val Leu Cys Trp Pro Gly Arg Leu Gln Leu Asp Ala 
                325                 330                 335     


Lys Val Glu Asn Pro Glu Ala Gly Gln Tyr Met Gly Asn Ile Asn Val 
            340                 345                 350         


Thr Phe Thr Pro Ser Ser Gln Thr Leu 
        355                 360     


<210>  51
<211>  373
<212>  PRT
<213>  Escherichia coli


<220>
<221>  MISC_FEATURE
<222>  (185)..(195)
<223>  Epitope

<400>  51

Met Lys Lys Gln Pro Ile Val Leu Thr Leu Gly Phe Phe Ser Phe Met 
1               5                   10                  15      


Val Gln Ala Ala Thr Thr Val Thr Ser Glu Phe Glu Ile Thr Asn Lys 
            20                  25                  30          


Thr Ile Glu Lys Tyr Thr Ile Ser Ser Thr Asp Ser Thr Met Thr Tyr 
        35                  40                  45              


Thr Asp Val Ser Gly Ser Gly Leu Tyr Lys Ile Ser Asp Gln Tyr Ser 
    50                  55                  60                  


Asp Ala Asn Val Asn Ile Arg Asn Tyr Gly Asn His Gln Phe Gly Leu 
65                  70                  75                  80  


Leu Arg Asn Asn Ser Thr Val Asn Ile Ile Met Lys Gly Val Asn Leu 
                85                  90                  95      


Gly His Thr Phe Thr Val Gln Gly Lys Tyr Ala Asn Ser Ala Val Ser 
            100                 105                 110         


Val Pro Asn Pro Gln Lys Tyr Phe Thr Val Arg Ser Asn Asn Gly Cys 
        115                 120                 125             


Ser Ser Val Ser Ser Ala Tyr Leu Gly Asn Ala Ser Tyr Thr Leu Tyr 
    130                 135                 140                 


Glu Ile Arg Ser Ser Asn Asp Val Thr Arg Asn Cys Ser Gly Gln Thr 
145                 150                 155                 160 


Asp Gln Tyr Thr His Met Pro Asn Asn Ser Gly Gln Val Asn Val Thr 
                165                 170                 175     


Gly Ile Tyr Arg Asp Phe Tyr Leu Asp Ile Gly Arg Leu Gln Ser Asp 
            180                 185                 190         


Ala Glu Tyr Arg Lys Ala Pro Pro Asp Thr Tyr Ile Gly Thr Gly Thr 
        195                 200                 205             


Phe Ala Gly Glu Val Leu Lys Asn Arg Val Gly Ser Gly Tyr Thr Pro 
    210                 215                 220                 


Thr Tyr Thr Asn Lys Ile Thr Ile Thr Lys Lys Pro Tyr Phe Glu Ser 
225                 230                 235                 240 


Val Thr Leu Pro Thr Val Asp Asn Ile Phe Asp Thr Arg Thr Ile Gly 
                245                 250                 255     


Arg Gln Ile Gln Gly Asn Leu Val Ile Pro Phe Val Ile Asn Gly His 
            260                 265                 270         


Phe Thr Pro Tyr Asn Thr Ile Ser Leu Gln Val Ile Ser Leu Asn Gly 
        275                 280                 285             


Phe Lys Leu Gln Ser Glu Asn Val Gly Ser Ser Ala Thr Ile Pro Tyr 
    290                 295                 300                 


Ser Leu Asn Met Thr Ile Gly Ser Glu Arg Arg Tyr Ser Leu Ala Thr 
305                 310                 315                 320 


Asn Gly Asn Gly Leu Gly Asn Val Thr Ile Asn Asn Leu Glu Ser Asp 
                325                 330                 335     


Gly Tyr Ser Ile Gln Gly Arg Phe Asn Ala Asp Phe Leu Ile Asp Lys 
            340                 345                 350         


Asn Thr Ala Val Thr Gly Asp Tyr Ala Asp Thr Leu Thr Ala Ile Phe 
        355                 360                 365             


Gln Ile Ser Leu Leu 
    370             


<210>  52
<211>  167
<212>  PRT
<213>  Escherichia coli


<220>
<221>  MISC_FEATURE
<222>  (53)..(63)
<223>  Epitope

<400>  52

Met Leu Lys Lys Ile Ile Ser Ala Ile Ala Leu Ile Ala Gly Thr Ser 
1               5                   10                  15      


Gly Val Val Asn Ala Gly Asn Trp Gln Tyr Lys Ser Leu Asp Val Asn 
            20                  25                  30          


Val Lys Ile Glu Gln Asn Phe Ile Pro Asp Ile Asp Ser Ala Val Arg 
        35                  40                  45              


Ile Ile Pro Val Asn Tyr Asp Ser Asp Pro Lys Leu Asp Ser Gln Leu 
    50                  55                  60                  


Tyr Thr Val Glu Met Thr Ile Pro Ala Gly Val Ser Ala Val Lys Ile 
65                  70                  75                  80  


Ala Pro Thr Asp Ser Leu Thr Ser Ser Gly Gln Gln Ile Gly Lys Leu 
                85                  90                  95      


Val Asn Val Asn Asn Pro Asp Gln Asn Met Asn Tyr Tyr Ile Arg Lys 
            100                 105                 110         


Asp Ser Gly Ala Gly Asn Phe Met Ala Gly Gln Lys Gly Ser Phe Pro 
        115                 120                 125             


Val Lys Glu Asn Thr Ser Tyr Thr Phe Ser Ala Ile Tyr Thr Gly Gly 
    130                 135                 140                 


Glu Tyr Pro Asn Ser Gly Tyr Ser Ser Gly Thr Tyr Ala Gly Asn Leu 
145                 150                 155                 160 


Thr Val Ser Phe Tyr Ser Asn 
                165         


<210>  53
<211>  206
<212>  PRT
<213>  Escherichia coli


<220>
<221>  MISC_FEATURE
<222>  (45)..(60)
<223>  Epitope

<400>  53

Met Ser Leu Leu Glu Val Ile Ile Val Leu Gly Ile Ile Gly Thr Ile 
1               5                   10                  15      


Ala Ala Gly Val Val Ile Leu Ala Gln Arg Ala Phe Asp Ser Arg Ala 
            20                  25                  30          


Val Thr Asp Leu Val Thr Asn Thr Asn Thr Val Arg Val Ala Met Lys 
        35                  40                  45              


Asp Ala Tyr Gln Arg Asp Gly Lys Tyr Pro Asp Phe Val Asp Pro Leu 
    50                  55                  60                  


Ser Leu Thr Ala Asn Thr Ile Lys Thr Asp Thr Ser Gly Ile Pro Ala 
65                  70                  75                  80  


Ala Gln Leu Val Gln Leu Gly Lys Ile Thr Pro Asp Glu Val Arg Asn 
                85                  90                  95      


Asn Ile Ser Gly Asp Phe Ile Ala Ile Gly Gly Ala Leu Thr Ser Asn 
            100                 105                 110         


Gly Ala Gln Val Lys Lys Gly Phe Ala Ile Glu Leu Asn Gly Leu Ser 
        115                 120                 125             


Gln Glu Gln Cys Arg Ser Ile Leu Gly Gln Val Gly Asn Asn Trp Glu 
    130                 135                 140                 


Tyr Val Ala Ile Gly Thr Ser Ala Ser Gly Ser Tyr Ala Met Thr Ala 
145                 150                 155                 160 


Thr Gly Val Asp Met Ser Val Ala Ala Ser Thr Thr Val Leu Arg Ser 
                165                 170                 175     


Leu Gly Asn Gly Gly Gln Thr Thr Leu Thr Ala Asp Lys Ile Leu Ser 
            180                 185                 190         


Thr Cys Thr Ala Gln Val Asn Ser Ile Thr Leu Gly Ser Arg 
        195                 200                 205     


<210>  54
<211>  7
<212>  PRT
<213>  Escherichia coli

<400>  54

Gln Val Thr Val Tyr Pro Val 
1               5           


<210>  55
<211>  1035
<212>  DNA
<213>  Escherichia coli

<400>  55
gggcgatacc cggaaactac agtaggtaat ctgacgaaga gttttcaagc ccctcgtctg       60

gatagaagcg tacaatcacc aatatataac atctttacga atcatgtggc tggatatagt      120

ttgagtcata gcttatatga caggattgtt tttttatgta catcctcgtc gaatccggtt      180

aatggtgctt gcccaaccat tggaacatct ggagttcaat acggtactac aaccataacc      240

ttgcagttta cagaaaaaag aagtctgata aaaagaaata ttaatcttgc aggtaataag      300

aaaccaatat gggagaatca gagttgcgac tttagcaatc taatggtgtt gaattcgaag      360

tcttggagct gtggggctca cggaaatgct aacggaacac ttctaaatct gtatatccct      420

gcaggagaaa tcaacaaatt gccttttgga gggatatggg aggcaactct gatcttacgc      480

ttatcaagat atggcgaagt cagtagcacc cattacggca attataccgt aaatattacg      540

gttgatttaa ctgataaagg taatattcag gtatggcttc cagggtttca cagcaacccg      600

cgtgtagacc tgaatctgcg ccctatcggt aattataaat atagtggtag taattcactc      660

gacatgtgtt tctatgatgg atatagtaca aacagtgata gcatggtaat aaagttccag      720

gatgataatc ctaccaattc atctgaatat aatctttata agataggggg cactgaaaaa      780

ttaccatatg ctgtttcact gcttatggga gaaaaaatat tttatccagt gaatggtcaa      840

tcatttacta tcaatgacag tagtgtactc gaaacaaact ggaatcgagt aaccgcagtt      900

gctatgccgg aagttaatgt tccagtatta tgctggccag caagattgct attaaatgct      960

gatgtaaatg ctcccgatgc aggacagtat tcaggacaga tatatataac atttacaccc     1020

agtgtcgaaa attta                                                      1035


<210>  56
<211>  1043
<212>  DNA
<213>  Escherichia coli

<400>  56
caatcatggc atacgaacgt agaggctggt tcaataaata aaacagagtc gataggcccc       60

atagaccgaa gtgctgctgc atcgtatcct gctcattata tatttcatga acatgttgct      120

ggttacaata aagatcactc tctttttgac aggatgacgt ttttatgtat gtcatcaaca      180

gatgcatcta aaggtgcatg tccgacagga gaaaactcca aatcctctca aggggagact      240

aatattaagc taatatttac tgaaaagaaa agtctggcca gaaaaacatt aaacttaaaa      300

ggatataaga gatttttata tgaatcagat agatgcattc attatgtcga taaaatgaat      360

ctcaattctc atactgttaa atgtgtaggt tcattcacaa gaggagtaga tttcacttta      420

tatatcccac aaggtgaaat tgatgggctt ctaactggag gtatatggga ggcaacacta      480

gagttacgag tcaaaaggca ttacgactat aatcatggta cttacaaagt taatatcaca      540

gttgatttga cagacaaagg aaatattcag gtctggacac caaagtttca tagcgatcct      600

agaattgatc tgaatttacg tcctgaaggt aatggtaaat attctggtag taacgtgctt      660

gagatgtgtc tctatgatgg ctatagtaca catagtcaaa gtatagaaat gaggtttcag      720

gatgactcac aaacaggaaa taatgaatat aatcttataa aaactggaga gccattaaaa      780

aaattgccat ataaactttc tcttctttta ggaggacgag agttttatcc aaataatgga      840

gaggctttta ctattaatga tacttcgtca ttgtttataa actggaatcg tattaagtct      900

gtatccttac cacagattag tattccagta ctatgctggc cagcaaactt gacatttatg      960

tcagagctaa ataatccaga agcgggtgag tattcaggaa tacttaacgt aacatttact     1020

cctagtagtt caagtctgta acg                                             1043


<210>  57
<211>  405
<212>  DNA
<213>  Escherichia coli

<400>  57
atgggcactc taaccaaaga actggcatta aatgtgcttt ctcctgcagc tctggatgca       60

gcttgggctc ctcaggataa tttaacatta tccaatactg gcgtttctaa tactttggtg      120

ggtgttttga ctctttcaaa taccagtatt gatacagtta gcattgcgag tacaaatgtt      180

tctgatacat ctaagaatgg tacagtaact tttgcacatg agacaaataa ctctgctagc      240

tttgccacca ccatttcaac agataatgcc aacattacgt tggataaaaa tgctggaaat      300

acgattgtta aaactacaaa tgggagtcag ttgccaacta atttaccact taagtttatt      360

accactgaag gtaacgaaca tttagtttca ggtaattaac ggccg                      405


<210>  58
<211>  1023
<212>  DNA
<213>  Escherichia coli


<220>
<221>  misc_feature
<222>  (331)..(331)
<223>  n is a, c, g, or t

<400>  58
gataaaattc ccggagatga aagcataact aatatttttg gcccgcgtga caggaacgaa       60

tcttccccca aacataatat attaaataac catattacag catacagtga aagtcatact      120

ctgtatgata ggatgacttt tttatgtttg tcttctcaca atacacttaa tggagcatgt      180

ccaaccagtg agaatcctag cagttcatcg gtcagcggtg aaacaaatat aacattacaa      240

tttacggaaa aaagaagttt aataaaaaga gagctacaaa ttaaaggcta taaacaatta      300

ttgttcaaaa gtgttaactg cccatccggc ntaacactta actcagctca ttttaactgt      360

aataaaaacg cggcttcagg tgcaagttta tatttatata ttcctgctgg cgaactaaaa      420

aatttgcctt ttggtggtat ctgggatgct actctgaagt taagagtaaa aagacgatat      480

agtgagacct atggaactta cactataaat atcactatta aattaactga taagggaaat      540

attcagatat ggttacctca gttcaaaagt gacgctcgcg tcgatcttaa cttgcgtcca      600

actggtgggg gcacatatat tggaagaaat tctgttgata tgtgctttta tgatggatat      660

agtactaaca gcagctcttt ggagataaga tttcaggata acaatcctaa atctgatggg      720

aaattttatc taaggaaaat aaatgatgac accaaagaaa ttgcatatac tttgtcactt      780

ctcttggcgg gtaaaagttt aactccaaca aatggaacgt cattaaatat tgctgacgca      840

gcttctctgg aaacaaactg gaatagaatt acagctgtca ccatgccaga aatcagtgtt      900

ccggtgttgt gttggcctgg acgtttgcaa ttggatgcaa aagtggaaaa tcccgaggct      960

ggacaatata tgggtaatat taatgttact ttcacaccaa gtagtcaaac actctagcgg     1020

ccg                                                                   1023


<210>  59
<211>  962
<212>  DNA
<213>  Escherichia coli

<400>  59
atggttatgg ttcaggctgc tacaacagtt acttcagaat ttgaaattac taataaaact       60

atcgaaaaat atacaatatc aagtacagat agtactatga catatactga tgtatcaggg      120

agtggtttat ataaaatatc agaccagtat tcagatgcca atgtcaatat tagaaattac      180

ggcaatcatc agtttggatt gctcagaaat aacagcactg ttaatattat catgaagggc      240

gtaaacttag gccacacttt tactgtacaa ggaaaatatg ccaattcagc cgtgtcagtt      300

cccaatcctc aaaaatattt taccgttaga agtaataatg gatgctcaag tgtatcttct      360

gcatatctag gtaatgcgag ttatacgcta tacgaaataa gatctagtaa tgatgttaca      420

cggaactgtt ccggacaaac ggatcagtac actcatatgc caaataatag tggtcaggta      480

aatgttacag gaatttacag agatttctac ttggatattg gtcgactgca atcagacgct      540

gagtatagga aagcacctcc tgatacctat ataggaacag ggacattcgc tggagaggtt      600

ttaaagaatc gagtaggttc tggttatact ccgacttata caaacaaaat aacaattaca      660

aaaaaaccat attttgaaag tgtgacattg cccacggtag ataatatctt cgatactcgt      720

actatcggca gacagattca ggggaatctt gtaattccat ttgtgattaa tgggcatttc      780

acaccataca atactatttc gttgcaggtc atttcactaa atgggtttaa gttacaaagt      840

gagaatgttg gttcctcagc aaccattcct tattcgctaa atatgacgat aggtagtgaa      900

cgacgttatt ccttggccac aaatgggaat ggtttgggaa atgttacaat aaataacggc      960

cg                                                                     962


<210>  60
<211>  393
<212>  DNA
<213>  Escherichia coli

<400>  60
aatattgagc aaaattttat tccagatatt gattccgctg ttcgtataat acctgttaat       60

tacgattcgg atccgaaact gaattcacag ttatatacgg ttgagatgac gatccctgca      120

ggtgtaagcg cagttaaaat cgtaccaaca gatagtctga catcttctgg acagcagatc      180

ggaaagctgg ttaatgtaaa caatccagat caaaatatga attattatat cagaaaggat      240

tctggcgctg gtaagtttat ggcagggcaa aaaggctcct tttctgtcaa agagaatacg      300

tcatacacat tctcagcaat ttatactggt ggcgaatacc ctaatagcgg atattcgtct      360

ggtacttatg caggaaattt gacttaacgg ccg                                   393


<210>  61
<211>  630
<212>  DNA
<213>  Escherichia coli


<220>
<221>  misc_feature
<222>  (600)..(600)
<223>  n is a, c, g, or t

<400>  61
atggctagca tgagcctgct ggaagttatc attgttcttg gcattatcgg tacgattgca       60

gccggtgtcg tgattctggc tcagcgtgcg tttgattcac gtgctgtgac tgatttagta      120

actaatacaa atacagtccg cgtagcaatg aaagatgctt atcaacgtga tggtaaatat      180

ccagattttg tggacccatt aagccttact gcaaatacaa ttaaaactga tacaagcgga      240

atacctgcag cacagttagt tcagcttggg aaaattacac cagacgaagt gcgtaataac      300

atttctggcg actttatcgc tattggcggt gctttaactt cgaatggtgc tcaagttaaa      360

aaaggttttg ctatcgaact taatggatta agccaagagc agtgccgttc tattcttggg      420

caagttggga ataactggga atatgttgct attggtactt ctgcgtctgg ttcatatgcc      480

atgacagcaa ctggtgtaga tatgtctgtg gccgcctcta caactgtttt acgctcttta      540

ggtaacggtg gacaaacaac cttgactgca gacaaaattc taagtacctg tactgctcan      600

gtaaactcaa ttactttagg tagccgttaa                                       630


<210>  62
<211>  480
<212>  DNA
<213>  Escherichia coli

<400>  62
atggcaaaag ccacgggcag cgtggagggc gaaaagtccc cccgtcgtgg cgtgcgcgcc       60

atggcgctga gcctgctgtc gggtatgatg ataatggccc atccggcgat gtcagcaaac      120

ctgccgaccg gtggccagat tgtggcaggt tcaggcagta tccagacgcc ttccggcaac      180

cagatgaata ttcatcagaa cagccagaac atggtggcca actggaacag ctttgacatt      240

ggtaaaggaa atacggtgca gttttaccag cccagcagca gtgcagtggc gctgaaccgt      300

gttgtgggtg gcggtgaatc gcagattatg ggtaacctga aggcgaatgg tcaggtgttc      360

ctggttaacc cgaacggcgt gctgtttggt aagggtgcca gtgtcagcac gtcaggtttt      420

gtggcatcga cccgcgacat taaaaacgac gacttcatga accgtcgtta caccttcagc      480


<210>  63
<211>  1161
<212>  DNA
<213>  Escherichia coli

<400>  63
atgaataaga ttttatttat ttttacattg tttttctctt cagtactttt tacatttgct       60

gtatcggcac aagaaggtag tagcaaccgg gcaaagattg accagacagg agattatact      120

aatatttttg gcccgcgtga caggaacgaa tcttccccca aacataatat attaaatgac      180

tatattacag catacagtga aagtcatact ctgtatgata ggatgatttt tttatgtttg      240

tcttctcaaa atacacttaa tggagcatgt ccaaccagtg agaatcctag cagttcatcg      300

gtcagtggcg aaacaaatat aacattacaa tttacggaaa aaagaagttt aattaaaaga      360

gagctacaaa ttaaaggcta taaacgatta ttgttcaaag gtgctaactg cccatcctac      420

ctaacactta actcagctca ttataataaa gacggagagg gagtttcacc tgggggtgca      480

agtttatatt tatatattcc tgctggcgaa ctaaaaaatt taccttttgg tggtatctgg      540

gatgctactc tgaagttaag agtaaaaaga cgatatgatc agacctatgg aacttacact      600

ataaatatca ctgttaaatt aactgataag ggaaatattc agatatggtt acctcagttc      660

aaaagtgacg ctcgcgtcga tcttaacttg agttttcaag cccctcgtca ggatagaagc      720

gtacaatcag gaagaaattc tgttgatatg tgcttttatg atggatatag tactaacagc      780

agctctttgg agctaagatt tcaggataac aatcctaaat ctgatgggaa attttatcta      840

aggaaaataa atgatgacac caaagaaatt gcatatactt tgtcacttct cttggcgggt      900

aaaagtgcag gtaataagaa accaatatgg gagaatcaga gttgcgacaa tattgctgac      960

gcagcttctc tggaaataaa ctggaataga attacagctg tcaccatgcc agaaatcagt     1020

gttccggtgt tgtgttggcc tggacgtttg caattggatg caaaaaaatc gccggatatt     1080

gaggattatc aggaacgccc ggcgaatggc tatatgggta atattaatat tactttcaca     1140

ccaagtagtc aaacactcta g                                               1161


<210>  64
<211>  386
<212>  PRT
<213>  Escherichia coli

<400>  64

Met Asn Lys Ile Leu Phe Ile Phe Thr Leu Phe Phe Ser Ser Val Leu 
1               5                   10                  15      


Phe Thr Phe Ala Val Ser Ala Gln Glu Gly Ser Ser Asn Arg Ala Lys 
            20                  25                  30          


Ile Asp Gln Thr Gly Asp Tyr Thr Asn Ile Phe Gly Pro Arg Asp Arg 
        35                  40                  45              


Asn Glu Ser Ser Pro Lys His Asn Ile Leu Asn Asp Tyr Ile Thr Ala 
    50                  55                  60                  


Tyr Ser Glu Ser His Thr Leu Tyr Asp Arg Met Ile Phe Leu Cys Leu 
65                  70                  75                  80  


Ser Ser Gln Asn Thr Leu Asn Gly Ala Cys Pro Thr Ser Glu Asn Pro 
                85                  90                  95      


Ser Ser Ser Ser Val Ser Gly Glu Thr Asn Ile Thr Leu Gln Phe Thr 
            100                 105                 110         


Glu Lys Arg Ser Leu Ile Lys Arg Glu Leu Gln Ile Lys Gly Tyr Lys 
        115                 120                 125             


Arg Leu Leu Phe Lys Gly Ala Asn Cys Pro Ser Tyr Leu Thr Leu Asn 
    130                 135                 140                 


Ser Ala His Tyr Asn Lys Asp Gly Glu Gly Val Ser Pro Gly Gly Ala 
145                 150                 155                 160 


Ser Leu Tyr Leu Tyr Ile Pro Ala Gly Glu Leu Lys Asn Leu Pro Phe 
                165                 170                 175     


Gly Gly Ile Trp Asp Ala Thr Leu Lys Leu Arg Val Lys Arg Arg Tyr 
            180                 185                 190         


Asp Gln Thr Tyr Gly Thr Tyr Thr Ile Asn Ile Thr Val Lys Leu Thr 
        195                 200                 205             


Asp Lys Gly Asn Ile Gln Ile Trp Leu Pro Gln Phe Lys Ser Asp Ala 
    210                 215                 220                 


Arg Val Asp Leu Asn Leu Ser Phe Gln Ala Pro Arg Gln Asp Arg Ser 
225                 230                 235                 240 


Val Gln Ser Gly Arg Asn Ser Val Asp Met Cys Phe Tyr Asp Gly Tyr 
                245                 250                 255     


Ser Thr Asn Ser Ser Ser Leu Glu Leu Arg Phe Gln Asp Asn Asn Pro 
            260                 265                 270         


Lys Ser Asp Gly Lys Phe Tyr Leu Arg Lys Ile Asn Asp Asp Thr Lys 
        275                 280                 285             


Glu Ile Ala Tyr Thr Leu Ser Leu Leu Leu Ala Gly Lys Ser Ala Gly 
    290                 295                 300                 


Asn Lys Lys Pro Ile Trp Glu Asn Gln Ser Cys Asp Asn Ile Ala Asp 
305                 310                 315                 320 


Ala Ala Ser Leu Glu Ile Asn Trp Asn Arg Ile Thr Ala Val Thr Met 
                325                 330                 335     


Pro Glu Ile Ser Val Pro Val Leu Cys Trp Pro Gly Arg Leu Gln Leu 
            340                 345                 350         


Asp Ala Lys Lys Ser Pro Asp Ile Glu Asp Tyr Gln Glu Arg Pro Ala 
        355                 360                 365             


Asn Gly Tyr Met Gly Asn Ile Asn Ile Thr Phe Thr Pro Ser Ser Gln 
    370                 375                 380                 


Thr Leu 
385     


<210>  65
<211>  1161
<212>  DNA
<213>  Escherichia coli

<400>  65
atgaataaga ttttatttat ttttacattg tttttctctt cagtactttt tacatttgct       60

gtatcggcac aagaaggtag tagcaaccgg gcaaagattg accagacagg agattatact      120

aatatttttg gcccgcgtga caggaacgaa tcttccccca aacataatat attaaatgac      180

tatattacag catacagtga aagtcatact ctgtatgata ggatgatttt tttatgtttg      240

tcttctcaaa atacacttaa tggagcatgt ccaaccagtg agaatcctag cagttcatcg      300

gtcagtggcg aaacaaatat aacattacaa tttacggaaa aaagaagttt aattaaaaga      360

gagctacaaa ttaaaggcta taaacgatta ttgttcaaag gtgctaactg cccatcctac      420

ctaacactta actcagctca ttataataaa gacggagagg gagtttcacc tgggggtgca      480

agtttatatt tatatattcc tgctggcgaa ctaaaaaatt taccttttgg tggtatctgg      540

gatgctactc tgaagttaag agtaaaaaga cgatatgatc agacctatgg aacttacact      600

ataaatatca ctgttaaatt aactgataag ggaaatattc agatatggtt acctcagttc      660

aaaagtgacg ctcgcgtcga tcttaacttg agttttcaag cccctcgtca ggatagaagc      720

gtacaatcag gaagaaattc tgttgatatg tgcttttatg atggatatag tactaacagc      780

agctctttgg agctaagatt tcaggataac aatcctaaat ctgatgggaa attttatcta      840

aggaaaataa atgatgacac caaagaaatt gcatatactt tgtcacttct cttggcgggt      900

aaaagtgcag gtaataagaa accaatatgg gagaatcaga gttgcgacaa tattgctgac      960

gcagcttctc tggaaataaa ctggaataga attacagctg tcaccatgcc agaaatcagt     1020

gttccggtgt tgtgttggcc tggacgtttg caattggatg caaaaaaatc gccggatatt     1080

gaggattatc aggaacgccc ggcgaatggc tatatgggta atattaatat tactttcaca     1140

ccaagtagtc aaacactcta g                                               1161


<210>  66
<211>  386
<212>  PRT
<213>  Escherichia coli

<400>  66

Met Asn Lys Ile Leu Phe Ile Phe Thr Leu Phe Phe Ser Ser Val Leu 
1               5                   10                  15      


Phe Thr Phe Ala Val Ser Ala Gln Glu Gly Ser Ser Asn Arg Ala Lys 
            20                  25                  30          


Ile Asp Gln Thr Gly Asp Tyr Thr Asn Ile Phe Gly Pro Arg Asp Arg 
        35                  40                  45              


Asn Glu Ser Ser Pro Lys His Asn Ile Leu Asn Asp Tyr Ile Thr Ala 
    50                  55                  60                  


Tyr Ser Glu Ser His Thr Leu Tyr Asp Arg Met Ile Phe Leu Cys Leu 
65                  70                  75                  80  


Ser Ser Gln Asn Thr Leu Asn Gly Ala Cys Pro Thr Ser Glu Asn Pro 
                85                  90                  95      


Ser Ser Ser Ser Val Ser Gly Glu Thr Asn Ile Thr Leu Gln Phe Thr 
            100                 105                 110         


Glu Lys Arg Ser Leu Ile Lys Arg Glu Leu Gln Ile Lys Gly Tyr Lys 
        115                 120                 125             


Arg Leu Leu Phe Lys Gly Ala Asn Cys Pro Ser Tyr Leu Thr Leu Asn 
    130                 135                 140                 


Ser Ala His Tyr Asn Lys Asp Gly Glu Gly Val Ser Pro Gly Gly Ala 
145                 150                 155                 160 


Ser Leu Tyr Leu Tyr Ile Pro Ala Gly Glu Leu Lys Asn Leu Pro Phe 
                165                 170                 175     


Gly Gly Ile Trp Asp Ala Thr Leu Lys Leu Arg Val Lys Arg Arg Tyr 
            180                 185                 190         


Asp Gln Thr Tyr Gly Thr Tyr Thr Ile Asn Ile Thr Val Lys Leu Thr 
        195                 200                 205             


Asp Lys Gly Asn Ile Gln Ile Trp Leu Pro Gln Phe Lys Ser Asp Ala 
    210                 215                 220                 


Arg Val Asp Leu Asn Leu Ser Phe Gln Ala Pro Arg Gln Asp Arg Ser 
225                 230                 235                 240 


Val Gln Ser Gly Arg Asn Ser Val Asp Met Cys Phe Tyr Asp Gly Tyr 
                245                 250                 255     


Ser Thr Asn Ser Ser Ser Leu Glu Leu Arg Phe Gln Asp Asn Asn Pro 
            260                 265                 270         


Lys Ser Asp Gly Lys Phe Tyr Leu Arg Lys Ile Asn Asp Asp Thr Lys 
        275                 280                 285             


Glu Ile Ala Tyr Thr Leu Ser Leu Leu Leu Ala Gly Lys Ser Ala Gly 
    290                 295                 300                 


Asn Lys Lys Pro Ile Trp Glu Asn Gln Ser Cys Asp Asn Ile Ala Asp 
305                 310                 315                 320 


Ala Ala Ser Leu Glu Ile Asn Trp Asn Arg Ile Thr Ala Val Thr Met 
                325                 330                 335     


Pro Glu Ile Ser Val Pro Val Leu Cys Trp Pro Gly Arg Leu Gln Leu 
            340                 345                 350         


Asp Ala Lys Lys Ser Pro Asp Ile Glu Asp Tyr Gln Glu Arg Pro Ala 
        355                 360                 365             


Asn Gly Tyr Met Gly Asn Ile Asn Ile Thr Phe Thr Pro Ser Ser Gln 
    370                 375                 380                 


Thr Leu 
385     


<210>  67
<211>  242
<212>  PRT
<213>  Escherichia coli

<400>  67

Met Ser Leu Leu Glu Val Ile Ile Val Leu Gly Ile Ile Gly Thr Ile 
1               5                   10                  15      


Ala Ala Gly Val Val Ile Leu Ala Gln Arg Ala Phe Asp Ser Arg Ala 
            20                  25                  30          


Val Thr Asp Leu Glu Ala Ala Pro Pro Glu Ala Gly Asn Tyr Thr Val 
        35                  40                  45              


Arg Val Ala Met Lys Asp Ala Tyr Gln Arg Asp Gly Lys Tyr Pro Asp 
    50                  55                  60                  


Phe Val Asp Pro Leu Ser Leu Thr Ala Asn Thr Ile Lys Thr Asp Thr 
65                  70                  75                  80  


Ser Gly Ile Pro Ala Ala Gln Leu Val Gln Leu Gly Lys Ala Asp Thr 
                85                  90                  95      


Gln Gly Thr Ala Pro Glu Ala Gly Asn Tyr Ile Ser Gly Asp Phe Ile 
            100                 105                 110         


Ala Ile Gly Gly Ala Val Glu Gly Glu Lys Ser Pro Arg Arg Gly Val 
        115                 120                 125             


Lys Lys Gly Phe Ala Ile Glu Leu Asn Gly Leu Thr Ser Gly Thr Ala 
    130                 135                 140                 


Pro Ser Ala Gly Lys Tyr Gln Glu Gln Cys Arg Ser Ile Leu Gly Gln 
145                 150                 155                 160 


Val Gly Ala Gly Ser Pro Val Thr Arg Ser Asp Thr Thr Ser Trp Glu 
                165                 170                 175     


Tyr Val Ala Gly Ser Asn Gly Gln Ala Asn Asn Asn Asp Ala Ser Gln 
            180                 185                 190         


Val Asp Met Ser Val Ala Ala Ser Thr Thr Val Leu Arg Ser Leu Gly 
        195                 200                 205             


Asn Lys Lys Ser Pro Asp Ile Glu Asp Tyr Gln Glu Arg Thr Ala Asp 
    210                 215                 220                 


Lys Ile Leu Ser Thr Cys Thr Ala Gln Val Asn Ser Ile Thr Leu Gly 
225                 230                 235                 240 


Ser Arg 
        


<210>  68
<211>  12
<212>  PRT
<213>  Escherichia coli

<400>  68

Ala Gly Ser Pro Val Thr Arg Ser Asp Thr Thr Ser 
1               5                   10          


<210>  69
<211>  13
<212>  PRT
<213>  Escherichia coli

<400>  69

Gly Ser Asn Gly Gln Ala Asn Asn Asn Asp Ala Ser Gln 
1               5                   10              


<210>  70
<211>  12
<212>  PRT
<213>  Escherichia coli

<400>  70

Thr Ser Gly Thr Ala Pro Ser Ala Gly Lys Tyr Gln 
1               5                   10          


<210>  71
<211>  13
<212>  PRT
<213>  Escherichia coli

<400>  71

Ala Asp Thr Gln Gly Thr Ala Pro Glu Ala Gly Asn Tyr 
1               5                   10              


<210>  72
<211>  10
<212>  PRT
<213>  Escherichia coli

<400>  72

Glu Ala Ala Pro Pro Glu Ala Gly Asn Tyr 
1               5                   10  


<210>  73
<211>  12
<212>  PRT
<213>  Escherichia coli

<400>  73

Lys Lys Ser Pro Asp Ile Glu Asp Tyr Gln Glu Arg 
1               5                   10          


<210>  74
<211>  729
<212>  DNA
<213>  Escherichia coli

<400>  74
atgagcctgc tggaagttat cattgttctt ggcattatcg gtacgattgc agccggtgtc       60

gtgattctgg ctcagcgtgc gtttgattca cgtgctgtga ctgatttaga agctgctccg      120

cctgaggcag gtaattacac agtccgcgta gcaatgaaag atgcttatca acgtgatggt      180

aaatatccag attttgtgga cccattaagc cttactgcaa atacaattaa aactgataca      240

agcggaatac ctgcagcaca gttagttcag cttgggaaag cagacacaca aggaactgcg      300

cctgaggcag gcaattacat ttctggcgac tttatcgcta ttggcggtgc tgtggagggc      360

gaaaagtccc cccgtcgtgg cgtgaaaaaa ggttttgcta tcgaacttaa tggattaaca      420

tccggaactg caccaagtgc aggtaagtat caagagcagt gccgttctat tcttgggcaa      480

gttggggctg gatcgccggt tacacgtagt gatacgacat cttgggaata tgttgctggt      540

agtaacggcc aagcgaataa caatgatgca agccaggtag atatgtctgt ggccgcctct      600

acaactgttt tacgctcttt aggtaacaaa aaatcgccgg atattgagga ttatcaggaa      660

cgcactgcag acaaaattct aagtacctgt actgctcagg taaactcaat tactttaggt      720

agccgttaa                                                              729


<210>  75
<211>  203
<212>  PRT
<213>  Escherichia coli

<400>  75

Met Lys Lys Lys Leu Leu Ile Ala Ser Val Leu Ala Met Ala Thr Val 
1               5                   10                  15      


Ser Gly Ser Val Leu Ala Ala Val Thr Asn Gly Gln Leu Thr Phe Asn 
            20                  25                  30          


Trp Gln Gly Val Val Pro Ser Ala Pro Val Thr Lys Asn Thr Trp Ala 
        35                  40                  45              


Phe Val Asn Gly Leu Asp Ile Pro Phe Thr Pro Gly Thr Glu Gln Leu 
    50                  55                  60                  


Asn Ile Thr Leu Gly Ala Asp Lys Gly Ile Thr Ala Arg Ser Val Lys 
65                  70                  75                  80  


Pro Tyr Asp Phe Phe Ile Val Pro Val Thr Gly Thr Val Thr Ala Gly 
                85                  90                  95      


Ser Pro Val Thr Arg Ser Asp Thr Thr Ser Met Asn Ser Val Lys Ala 
            100                 105                 110         


Phe Leu Ser Ser Glu Pro Val Ser Asn Gly Phe Val Gly Asn Lys Gln 
        115                 120                 125             


Leu Thr Leu Ser Thr Thr Ala Glu Ala Val Thr Gly Gln Val Ala Ile 
    130                 135                 140                 


Thr Leu Asn Gly Gln Pro Leu Lys Val Gly Ser Ala Asn Ala Thr Thr 
145                 150                 155                 160 


Val Ala Met Asp Thr Asn Lys Lys Glu Ser His Ile Ser Ile Asp Met 
                165                 170                 175     


Asn Ala Lys Ala Ser Ala Ser Asp Val Ala Glu Gly Ser Ala Ile Asn 
            180                 185                 190         


Phe Val Ala Pro Val Thr Phe Ala Val Asp Ile 
        195                 200             


<210>  76
<211>  612
<212>  DNA
<213>  Escherichia coli

<400>  76
atgaagaaaa aattactgat agcttcagta ttagcaatgg caaccgtatc aggttctgtt       60

ttggctgctg ttacaaatgg ccagctcaca tttaattggc agggagtggt tccttctgct      120

cccgttacta aaaatacgtg ggcttttgtg aacggattgg atataccgtt tactcctggt      180

actgaacagt tgaatatcac ccttggtgca gataaaggta tcacagcccg ttcggttaag      240

ccttatgatt ttttcattgt tccagttact ggaacagtaa ctgctggatc gccggttaca      300

cgtagtgata cgacatctat gaatagtgtg aaagcttttc tatcaagtga acccgtttct      360

aatggttttg ttggcaacaa gcagttaacc ctgagcacca cagcagaagc agttacgggg      420

caagtcgcaa tcactttaaa tggtcagccg cttaaagtgg ggagtgctaa tgcaacaact      480

gttgctatgg ataccaataa aaaagagtct catatttcta ttgatatgaa tgccaaggca      540

agtgcttcgg atgtggcgga gggttcagct attaactttg tagctccggt aacatttgct      600

gttgatattt aa                                                          612


<210>  77
<211>  26
<212>  DNA
<213>  Escherichia coli

<400>  77
cgccatggaa atggcaaccg tatcag                                            26


<210>  78
<211>  31
<212>  DNA
<213>  Escherichia coli

<400>  78
tcggccgctt tacgccacat ccgaagcact t                                      31


<210>  79
<211>  196
<212>  PRT
<213>  Escherichia coli

<400>  79

Met Arg Lys Ile Thr Ser Leu Ile Met Ala Val Thr Leu Met Asn Ser 
1               5                   10                  15      


Ser Ala Phe Ala Ala Ile Gly Ser Asn Gly Gln Ala Asn Asn Asn Asp 
            20                  25                  30          


Ala Ser Gln Ala Glu Leu His Phe Thr Gly Lys Leu Thr Ser Ser Leu 
        35                  40                  45              


Cys Gln Val Ala Thr Ser Asp Val Lys Lys Glu Ile Asp Leu Gly Glu 
    50                  55                  60                  


Leu Ser Lys Ala Ala Leu Ile Ala Ser Gly Arg Gly Pro Ser Gln Ser 
65                  70                  75                  80  


Phe Ser Val Ser Leu Val Asn Cys Asp Pro Thr Ile Asn Thr Ile Ser 
                85                  90                  95      


Tyr Ala Leu Gln Asp Lys Asn Gly Ser Val Gly Asn Tyr Leu Val Asn 
            100                 105                 110         


Gln Ser Gly Asp Thr Met Ala Lys Gly Val Gly Val Tyr Ile Glu Asn 
        115                 120                 125             


Asn Leu Asn Ser Pro Leu Lys Val Asp Gly Ser Leu Asn Thr Val Gly 
    130                 135                 140                 


Val Gln Lys Asp Gly Ala Thr Ala Leu Pro Asp Gln Val Ile Pro Leu 
145                 150                 155                 160 


Thr Ala Tyr Ile Gly Ser Thr Thr Pro Gly Ala Val Ala Asp Phe Ala 
                165                 170                 175     


Thr Val Thr Pro Gly Leu Val Asp Ala Asn Ala Val Met Thr Ile Arg 
            180                 185                 190         


Ala Ser Ala Pro 
        195     


<210>  80
<211>  591
<212>  DNA
<213>  Escherichia coli

<400>  80
atgagaaaaa ttacgtctct gatcatggct gttactctaa tgaatagctc agccttcgct       60

gcgatcggta gtaacggcca agcgaataac aatgatgcaa gccaggctga attgcatttc      120

actggtaagt tgacttccag tctatgccag gttgctacat cagatgttaa aaaagaaatt      180

gatctagggg aacttagcaa agctgcgtta attgcatcag gtcgagggcc atcgcagtct      240

ttttcagtta gtttggtaaa ctgtgacccc acaataaata caattagtta tgctttgcag      300

gataaaaacg gcagtgtagg taattatctt gtaaaccagt caggtgacac gatggctaag      360

ggggttggtg tctatattga aaataattta aatagccctt tgaaggttga tggttcactt      420

aatactgttg gtgttcagaa agatggtgct acggctttac ctgatcaggt tattccgttg      480

actgcttata ttggtagcac aactccggga gctgtggccg attttgctac agtaactcct      540

ggcttagttg atgcaaatgc agtaatgact attcgtgcga gcgcaccata a               591


<210>  81
<211>  39
<212>  DNA
<213>  Escherichia coli

<400>  81
catgccatgg aaatggctgt tactctaatg aatagctca                              39


<210>  82
<211>  39
<212>  DNA
<213>  Escherichia coli

<400>  82
gagtcggccg ctttatgaac accaacagta ttaagtgaa                              39


<210>  83
<211>  175
<212>  PRT
<213>  Escherichia coli

<400>  83

Met Lys Leu Lys Lys Thr Ile Gly Ala Met Ala Leu Ser Thr Ile Phe 
1               5                   10                  15      


Val Ala Val Ser Ala Ser Ala Val Glu Lys Asn Ile Thr Val Thr Ala 
            20                  25                  30          


Ser Val Asp Pro Thr Ile Asp Ile Leu Gln Ala Asn Gly Ser Ala Leu 
        35                  40                  45              


Pro Thr Ala Val Asp Leu Thr Tyr Leu Pro Gly Ala Lys Thr Phe Glu 
    50                  55                  60                  


Asn Tyr Ser Val Leu Thr Gln Ile Tyr Thr Asn Asp Pro Ser Lys Gly 
65                  70                  75                  80  


Leu Asp Val Arg Leu Val Asp Thr Pro Lys Leu Thr Asn Ile Leu Gln 
                85                  90                  95      


Pro Thr Ser Thr Ile Pro Leu Thr Val Ser Trp Ala Gly Lys Thr Leu 
            100                 105                 110         


Ser Thr Ser Ala Gln Lys Ile Ala Val Gly Asp Leu Gly Phe Gly Ser 
        115                 120                 125             


Thr Gly Thr Ala Gly Val Ser Asn Ser Lys Glu Leu Val Ile Gly Ala 
    130                 135                 140                 


Thr Thr Ser Gly Thr Ala Pro Ser Ala Gly Lys Tyr Gln Gly Val Val 
145                 150                 155                 160 


Ser Ile Val Met Thr Gln Ser Thr Asp Thr Ala Ala Pro Val Pro 
                165                 170                 175 


<210>  84
<211>  510
<212>  DNA
<213>  Escherichia coli

<400>  84
atgaaattaa aaaaaactat tggcgcaatg gctctgagca caatatttgt agcggtgagt       60

gcttcagcag tagagaaaaa tattactgtg acagccagtg ttgatcctac tattgatatt      120

cttcaagcaa atggttctgc gctaccgaca gctgtagatt taacttatct acctggtgca      180

aaaacttttg aaaattacag tgttctaacc cagatttaca caaatgaccc ttcaaaaggt      240

ttagatgttc gactggttga tacaccgaaa cttacaaata ttttgcaacc gacatctacc      300

attcctctta ctgtctcatg ggcagggagg acattaagta caagtgctca gaagatcgca      360

gttggcgatc tgggttttgg ttccaccgga acggcaggtg tttcgaatag taaagaatta      420

gtaattggag caactacatc cggaactgca ccaagtgcag gtaagtatca aggcgtcgtt      480

tccattgtaa tgactcaatc gacaaactaa                                       510


<210>  85
<211>  37
<212>  DNA
<213>  Escherichia coli

<400>  85
catgccatgg aaatggctct gagcacaata tttgtag                                37


<210>  86
<211>  42
<212>  DNA
<213>  Escherichia coli

<400>  86
gagtcggccg ctttagtttg tcgattgagt cattacaatg ga                          42


<210>  87
<211>  168
<212>  PRT
<213>  Escherichia coli

<400>  87

Met Lys Leu Lys Lys Thr Ile Gly Ala Met Ala Met Ala Thr Leu Phe 
1               5                   10                  15      


Ala Thr Met Ala Ala Ser Ala Val Glu Lys Asn Ile Thr Val Arg Ala 
            20                  25                  30          


Ser Val Asp Pro Lys Leu Asp Leu Leu Gln Ala Asp Gly Thr Ser Leu 
        35                  40                  45              


Pro Asp Ser Ile Ala Leu Thr Tyr Ser Ser Ala Ser Asn Asn Phe Glu 
    50                  55                  60                  


Val Tyr Ser Leu Asn Thr Ala Ile His Thr Asn Asp Lys Ser Lys Gly 
65                  70                  75                  80  


Val Val Val Lys Leu Ser Ala Ser Pro Val Leu Ser Asn Ile Met Lys 
                85                  90                  95      


Pro Asn Ser Gln Ile Pro Met Lys Val Thr Leu Gly Gly Lys Thr Leu 
            100                 105                 110         


Asn Thr Thr Asp Thr Glu Phe Thr Val Asp Thr Leu Asn Phe Gly Thr 
        115                 120                 125             


Ser Gly Val Glu Asn Val Ser Ser Thr Gln Gln Leu Thr Ile His Ala 
    130                 135                 140                 


Asp Thr Gln Gly Thr Ala Pro Glu Ala Gly Asn Tyr Gln Gly Ile Ile 
145                 150                 155                 160 


Ser Leu Ile Met Thr Gln Lys Thr 
                165             


<210>  88
<211>  507
<212>  DNA
<213>  Escherichia coli

<400>  88
atgaaactga agaaaacaat tggcgcaatg gctatggcga ctctgtttgc caccatggct       60

gcctctgcag tcgaaaaaaa tattactgtg agggcaagtg ttgaccctaa acttgatctt      120

ctgcaagcag atggaacttc actgccggac tctatcgcat taacctattc ttcggcttca      180

aataattttg aagtttactc tcttaatact gctattcata caaatgacaa aagcaaggga      240

gttgtagtga agctgtcagc ttcaccagtt ctgtccaata ttatgaagcc aaactcgcaa      300

attccgatga aagtgacttt gggggggaag acgctgaata caactgatac tgagtttact      360

gttgatactc tgaactttgg tacatctggt gttgaaaacg tttcttccac tcaacagctt      420

acgattcatg cagacacaca aggaactgcg cctgaggcag gcaattacca aggtattatt      480

tctcttatca tgactcaaaa aacttaa                                          507


<210>  89
<211>  37
<212>  DNA
<213>  Escherichia coli

<400>  89
ctagctagct agatggctat ggcgactctg tttgcca                                37


<210>  90
<211>  41
<212>  DNA
<213>  Escherichia coli

<400>  90
gagtcggccg ctttataata ccttggtaat tgcctgcctc a                           41


<210>  91
<211>  166
<212>  PRT
<213>  Escherichia coli

<400>  91

Met Lys Leu Lys Lys Thr Ile Gly Ala Met Ala Met Ala Thr Leu Phe 
1               5                   10                  15      


Ala Thr Met Ala Ala Ser Ala Val Glu Lys Asn Ile Thr Val Arg Ala 
            20                  25                  30          


Ser Val Asp Pro Lys Leu Asp Leu Leu Gln Ala Asp Gly Thr Ser Leu 
        35                  40                  45              


Pro Asp Ser Ile Ala Leu Thr Tyr Ser Ser Ala Ser Asn Asn Phe Glu 
    50                  55                  60                  


Val Tyr Ser Leu Asn Thr Ala Ile His Thr Asn Asp Lys Thr Lys Ala 
65                  70                  75                  80  


Val Val Val Lys Leu Ser Ala Pro Ala Val Leu Ser Asn Ile Met Lys 
                85                  90                  95      


Pro Ser Ser Gln Ile Pro Met Lys Val Thr Leu Gly Gly Lys Thr Leu 
            100                 105                 110         


Ser Thr Ala Asp Ala Glu Phe Ala Ala Asp Thr Leu Asn Phe Gly Ala 
        115                 120                 125             


Ser Gly Val Glu Asn Val Ser Ser Val Gln Gln Leu Thr Ile His Ala 
    130                 135                 140                 


Glu Ala Ala Pro Pro Glu Ala Gly Asn Tyr Gln Gly Val Ile Ser Leu 
145                 150                 155                 160 


Ile Met Thr Gln Lys Thr 
                165     


<210>  92
<211>  501
<212>  DNA
<213>  Escherichia coli

<400>  92
atgaaactga agaaaacaat tggcgcaatg gctatggcga ctctgtttgc caccatggct       60

gcctctgcag tcgaaaaaaa tattactgtg agggcaagtg ttgaccctaa acttgatctt      120

ctgcaagcag atggaacttc actgccggac tctatcgcat taacctattc ttcggcttca      180

aataattttg aagtttactc tcttaatact gctattcata caaatgacaa aaccaaggca      240

gttgtagtga agctgtcagc tccagcagtt ctgtccaata ttatgaagcc aagctcgcaa      300

attccgatga aagtgacttt gggggggaag acgctgagta cagctgatgc tgagtttgct      360

gctgatactc tgaactttgg tgcatctggt gttgaaaacg tttcttccgt tcaacagctt      420

acgattcatg cagaagctgc tccgcctgag gcaggtaatt accaaggtgt tatttctctt      480

atcatgactc aaaaaactta a                                                501


<210>  93
<211>  37
<212>  DNA
<213>  Escherichia coli

<400>  93
ctagctagct agatggctat ggcgactctg tttgcca                                37


<210>  94
<211>  39
<212>  DNA
<213>  Escherichia coli

<400>  94
gagtcggccg ctttagagtc atgataagag aaataacac                              39


<210>  95
<211>  206
<212>  PRT
<213>  Escherichia coli

<400>  95

Met Ser Leu Leu Glu Val Ile Ile Val Leu Gly Ile Ile Gly Thr Ile 
1               5                   10                  15      


Ala Ala Gly Val Val Ile Leu Ala Gln Arg Ala Phe Asp Ser Arg Ala 
            20                  25                  30          


Val Thr Asp Leu Val Thr Asn Thr Asn Thr Val Arg Val Ala Met Lys 
        35                  40                  45              


Asp Ala Tyr Gln Arg Asp Gly Lys Tyr Pro Asp Phe Val Asp Pro Leu 
    50                  55                  60                  


Ser Leu Thr Ala Asn Thr Ile Lys Thr Asp Thr Ser Gly Ile Pro Ala 
65                  70                  75                  80  


Ala Gln Leu Val Gln Leu Gly Lys Ile Thr Pro Asp Glu Val Arg Asn 
                85                  90                  95      


Asn Ile Ser Gly Asp Phe Ile Ala Ile Gly Gly Ala Leu Thr Ser Asn 
            100                 105                 110         


Gly Ala Gln Val Lys Lys Gly Phe Ala Ile Glu Leu Asn Gly Leu Ser 
        115                 120                 125             


Gln Glu Gln Cys Arg Ser Ile Leu Gly Gln Val Gly Asn Asn Trp Glu 
    130                 135                 140                 


Tyr Val Ala Ile Gly Thr Ser Ala Ser Gly Ser Tyr Ala Met Thr Ala 
145                 150                 155                 160 


Thr Gly Val Asp Met Ser Val Ala Ala Ser Thr Thr Val Leu Arg Ser 
                165                 170                 175     


Leu Gly Asn Gly Gly Gln Thr Thr Leu Thr Ala Asp Lys Ile Leu Ser 
            180                 185                 190         


Thr Cys Thr Ala Gln Val Asn Ser Ile Thr Leu Gly Ser Arg 
        195                 200                 205     


<210>  96
<211>  621
<212>  DNA
<213>  Escherichia coli

<400>  96
atgagcctgc tggaagttat cattgttctt ggcattatcg gtacgattgc agccggtgtc       60

gtgattctgg ctcagcgtgc gtttgattca cgtgctgtga ctgatttagt aactaataca      120

aatacagtcc gcgtagcaat gaaagatgct tatcaacgtg atggtaaata tccagatttt      180

gtggacccat taagccttac tgcaaataca attaaaactg atacaagcgg aatacctgca      240

gcacagttag ttcagcttgg gaaaattaca ccagacgaag tgcgtaataa catttctggc      300

gactttatcg ctattggcgg tgctttaact tcgaatggtg ctcaagttaa aaaaggtttt      360

gctatcgaac ttaatggatt aagccaagag cagtgccgtt ctattcttgg gcaagttggg      420

aataactggg aatatgttgc tattggtact tctgcgtctg gttcatatgc catgacagca      480

actggtgtag atatgtctgt ggccgcctct acaactgttt tacgctcttt aggtaacggt      540

ggacaaacaa ccttgactgc agacaaaatt ctaagtacct gtactgctca ggtaaactca      600

attactttag gtagccgtta a                                                621


<210>  97
<211>  39
<212>  DNA
<213>  Escherichia coli

<400>  97
catgccatgg gcatgagcct gctggaagtt atcattgtt                              39


<210>  98
<211>  37
<212>  DNA
<213>  Escherichia coli

<400>  98
gagtcggccg ctttaacggc tacctaaagt aattgag                                37


<210>  99
<211>  216
<212>  PRT
<213>  Escherichia coli

<400>  99

Val Ser Glu Ile Thr Thr Gly Val Gly Asn Ala Lys Ala Thr Gly Ser 
1               5                   10                  15      


Val Glu Gly Glu Lys Ser Pro Arg Arg Gly Val Arg Ala Met Ala Leu 
            20                  25                  30          


Ser Leu Leu Ser Gly Met Met Ile Met Ala His Pro Ala Met Ser Ala 
        35                  40                  45              


Asn Leu Pro Thr Gly Gly Gln Ile Val Ala Gly Ser Gly Ser Ile Gln 
    50                  55                  60                  


Thr Pro Ser Gly Asn Gln Met Asn Ile His Gln Asn Ser Gln Asn Met 
65                  70                  75                  80  


Val Ala Asn Trp Asn Ser Phe Asp Ile Gly Lys Gly Asn Thr Val Gln 
                85                  90                  95      


Phe Asp Gln Pro Ser Ser Ser Ala Val Ala Leu Asn Arg Val Val Gly 
            100                 105                 110         


Gly Gly Glu Ser Gln Ile Met Gly Asn Leu Lys Ala Asn Gly Gln Val 
        115                 120                 125             


Phe Leu Val Asn Pro Asn Gly Val Leu Phe Gly Glu Gly Ala Ser Val 
    130                 135                 140                 


Ser Thr Ser Gly Phe Val Ala Ser Thr Arg Asp Ile Lys Asn Asp Asp 
145                 150                 155                 160 


Phe Met Asn Arg Arg Tyr Thr Phe Ser Gly Gly Gln Lys Ala Gly Ala 
                165                 170                 175     


Ala Ile Val Asn Gln Gly Glu Leu Thr Thr Asn Ala Gly Gly Tyr Ile 
            180                 185                 190         


Val Leu Ala Ala Asp Arg Val Ser Asn Ser Gly Thr Ile Arg Thr Pro 
        195                 200                 205             


Gly Gly Lys Thr Val Leu Ala Ala 
    210                 215     


<210>  100
<211>  5304
<212>  DNA
<213>  Escherichia coli

<400>  100
atgaaccgta tatataaact gaagtttgac aaacgccgca acgaactggt ggtggtgagt       60

gaaatcacca ccggcgtggg taatgcaaaa gccacgggca gcgtggaggg cgaaaagtcc      120

ccccgtcgtg gcgtgcgcgc catggcgctg agcctgctgt cgggtatgat gataatggcc      180

catccggcga tgtcagcaaa cctgccgacc ggtggccaga ttgtggcagg ttcaggcagt      240

atccagacgc cttccggcaa ccagatgaat attcatcaga acagccagaa catggtggcc      300

aactggaaca gctttgacat tggtaaagga aatacggtgc agtttgacca gcccagcagc      360

agtgcggtgg cgctgaaccg tgttgtgggt ggcggtgaat cgcagattat gggtaacctg      420

aaggcgaatg gtcaggtgtt cctggttaac ccgaacggcg tgctgtttgg tgagggggcc      480

agtgtcagca cgtcaggttt tgtggcatcg acccgcgaca ttaaaaacga cgacttcatg      540

aaccgtcgtt acaccttcag cggcggacag aaagccgggg cagcgattgt gaaccagggg      600

gaactgacca caaatgccgg tggctatatt gtgctggcag cagacagggt cagcaacagt      660

ggcaccatcc gtacgccggg cggcaagacc gtcctggcgg ccagcgagcg catcacgctg      720

cagctggata atggtggcct gatgtccgtg caggtgacag gagatgtggt taatgccctg      780

gtggaaaacc gcggtctggt cagtgcccgg gatggtcagg tgtacctgac cgcacttggc      840

cggggtatgc tgatgaacac ggtactgaac gtgagcgggg tggtggaagc cagcggtatg      900

caccgtcagg acggtaacat tgtactggac ggtggcgaca gtggtgtggt gcacctgagt      960

ggtaccctgc aggcggacaa tgcgtccggt cagggtggta aggttgtcgt gcagggtaag     1020

aatattctgc tggacaaggg cagcaacatc acagcaaccg gtggtcaggg cggcggtgaa     1080

gtgtatgtcg gtggcggctg gcagggtaag gacagcaaca tccgtaatgc ggacaaggtg     1140

gtgatgcagg gcggcgcccg cattgacgtt tctgcaacgc agcagggtaa cggcggtacg     1200

gctgtgctgt ggtcagacag ctacaccaac ttccatggtc agattagcgc gaagggcggt     1260

gagaccggcg gtaacggtgg tcgggtggag acctcttcgc acggtaacct gcaggcattt     1320

ggtacggtca gtgcatccgc gaagaaaggc aaggcgggta actggctgct ggactcggcg     1380

gatatcacca ttgtgaatgg tagcaatgtt agcaaaactg agacgactca atcgccgccg     1440

cacacgcaat ttgcacccac cgctgcgggc tctgcggtca gcaataccag tatcaacaac     1500

aggctgaaca acgggaccag tgtcactatt ctgacccatc gcacaagaac aggcacagct     1560

cagggcggga atattaccgt taatgcggca attaacaaaa gcaacggaag tgatgtcaac     1620

ctgacgctgc aggctggcgg caacatcacg gtaaacaaca gcatcacgtc caccgagggt     1680

aagctgaatg ttaatctgtc gggcgccagg accagcaatg gcagtatcac cattagcaat     1740

aacgccaata taacgaccaa tggtggggat ataactgttg ggacgacaaa tacttcaaac     1800

cgtgtgaata tatctattaa taacactacc ctgaatgcgt caaatggcaa catccagttg     1860

accgggaccg ggaccgatag cgggattctg tttgctggca acaacaggct gacggccagt     1920

aacattgctc ttaccgggaa cagtacgagt gggaatgcca tcaaccttac aggcactgcc     1980

acgctgaatg ccacgaataa cattactctt accgggagca gtacgagtgg gaatgccatc     2040

aaccttaaag gcaacaacac gctgacggcc agtaacatta ctcttaccgg ggaaagtacg     2100

agtgggaatg ccatcaacct tacagacact acaggcacta ccacgctgaa tgccacgaat     2160

aacatcacta tgcaggggac ccgtgttcag attaaacact ccaacatcac cgcgggcaac     2220

tttgcgctga atgcgacagt ggccggctct gaaatcagca ataccacgct gacggccacc     2280

aacaacatca acctggcggc taagacgaac agtgcgagct ctggtgttta cctgaaagat     2340

gcaagaatta catccaccaa tggcagtatc acggctaacg gtactgccac agcaaacggc     2400

aaggccacgc atctggacgg caacgtcacc ctgaatgcgt caaatggcag aatcaagttg     2460

accgggaacg ggcacggtag cgcctccggg attctgtttg ctggcaacaa caggctgacg     2520

gccagtaaca ttgctcttac cgggaacagt acgagtggga atgccatcaa ccttacaggc     2580

actgccacgc tgaatgccac gaatgacatt actcttaccg ggagcagtac gagtgggaat     2640

gccatcaacc ttacaggcac tgccacgctg aatgccacga ataacattac tcttaccggg     2700

agcagtacga gtgggaatgc catcaacctt aaaggcaaca acacgctgac ggccagtaac     2760

attactctta ccggggaaag tacgagtggg aatgccatca accttacaga cactacaggc     2820

actaccacgc tgaatgccac gaataacatc actatgcagg ggacccgtgt tcagattaaa     2880

cactccaaca tcaccgcggg caactttgcg ctgaatgcga cagtggccgg ctctgaaatc     2940

agcaatacca cgctgacggc caccaacaac atcaacctgg cggctaagac gaacagtgcg     3000

agctctggtg tttacctgaa agatgcaaga attacatcca ccaatggcag tatcacggct     3060

aacggtactg ccacagcaaa cggcaaggcc acgcatctgg acggcaacgt caccctgaat     3120

gcgtcaaatg gcagaatcaa gttgaccggg aacgggcacg gtagcgcctc cgggattctg     3180

tttgctggca acaacaggct gacggccagt aacattgctc ttaccgggaa cagtacgagt     3240

gggaatgcca tcaaccttac aggcactgcc acgctgaatg ccacgaatga cattactctt     3300

accgggagca gtacgagtgg gaatgccatc aaccttacag gcactgccac gctgaatgcc     3360

acgaataaca ttactcttac cgggagcagt acgagtggga atgccatcaa ccttaaaggc     3420

aacaacacgc tgacggccag taacattact cttaccgggg aaagtacgag tgggaatgcc     3480

atcaacctta cagacactac aggcactacc acgctgaatg ccacgaataa catcactatg     3540

caggggaccc gtgttcagat taaacactcc aacatcaccg cgggcaactt tgcgctgaat     3600

gcgacagtgg ccggctctga aatcagcaat accacgctga cggccaccaa caacatcaac     3660

ctggcggcta agacgaacag tgcgagctct ggtgtttacc tgaaagatgc aagaattaca     3720

tccaccaatg gcagtatcac ggctaacggt actgccacag caaacggcaa ggccacgcat     3780

ctggacggca acgtcaccct gaatgcgtca aatggcagaa tcaagttgac cgggaacggg     3840

cacggtagcg cctccgggat tctgtttgct ggcaacaaca ggctgacggc cagtaacatt     3900

gctcttaccg ggaacagtac gagtgggaat gccatcaacc ttacaggcac tgccacgctg     3960

aatgccacga atgacattac tcttaccggg agcagtacga gtgggaatgc catcaacctt     4020

acaggcactg ccacgctgaa tgccacgaat aacattactc ttaccgggag cagtacgagt     4080

gggaatgcca tcaaccttaa aggcaacaac acgctgacgg ccagtaacat tactcttacc     4140

ggggaaagta cgagtgggaa tgccatcaac cttacagaca ctacaggcac taccacgctg     4200

aatgccacga ataacatcac tatgcagggg acccgtgttc agattaaaca ctccaacatc     4260

accgcgggca actttgcgct gaatgcgaca gtggccggct ctgaaatcag caataccacg     4320

ctgacggcca ccaacaacat caacctggcg gctaagacga acagtgcgag ctctggtgtt     4380

tacctgaaag atgcaagaat tacatccact aatggcagta tcacgactaa cggtactgcc     4440

acagcaaacg gcaaggccac gcatctggac ggcaacgtca ccctgaatgc gtcaaatggc     4500

agaatcaagt tgaccgggaa cgggcacggt agcgcctccg ggattctgtt tgctggcaac     4560

aacaggctga cggccagtaa cattgctctt accgggaaca gtacgagtgg gaatgccatc     4620

aaccttacag gcactgccac gctgaatgcc acgaatgaca ttactcttac cgggagcagt     4680

acgagtggga atgccatcaa ccttacaggc actgccacgc tgaatgccac gaataacatt     4740

actcttaccg ggagcagtac gagtgggaat gccatcaacc ttaaaggcaa caacacgctg     4800

acggccagta acattactct taccggggaa agtacgagtg ggaatgccat caaccttaca     4860

gacactacag gcactaccac gctgaatgcc acgaataaca tcactatgca ggggacccgt     4920

gttcagatta aacactccaa catcaccgcg ggcaactttg cgctgaatgc gacagtggcc     4980

ggctctgaaa tcagcaatac cacgctgacg gccaccaaca acatcaacct ggcggctaag     5040

acgaacagtg cgagctctgg tgtttacctg aaagatgcaa gaattacatc caccaatggc     5100

agtatcacgg ctaacggtac tgccccagca aacgacaatg ccacgtatct ggacggcaac     5160

gtcaccctga atgcgtcaaa tggcagcatc aagttgaccg ggaacgggaa cggtagcacc     5220

tccgggattc tgtttgctgg caacaacacg ctgacggcca gtaacattac tcttaccggg     5280

aacagtgagg tgtactggca atag                                            5304


<210>  101
<211>  33
<212>  DNA
<213>  Escherichia coli

<400>  101
ctagctagct agatgaaccg tatatataaa ctg                                    33


<210>  102
<211>  40
<212>  DNA
<213>  Escherichia coli

<400>  102
gagtcggccg ctttataatc tgaccatgga agttggtgta                             40


<210>  103
<211>  290
<212>  PRT
<213>  Escherichia coli

<400>  103

Met Ser His Tyr Lys Thr Gly His Lys Gln Pro Arg Phe Arg Tyr Ser 
1               5                   10                  15      


Val Leu Ala Arg Cys Val Ala Trp Ala Asn Ile Ser Val Gln Val Leu 
            20                  25                  30          


Phe Pro Leu Ala Val Thr Phe Thr Pro Val Met Ala Ala Arg Ala Gln 
        35                  40                  45              


His Ala Val Gln Pro Arg Leu Ser Met Gly Asn Thr Thr Val Thr Ala 
    50                  55                  60                  


Asp Asn Asn Val Glu Lys Asn Val Ala Ser Phe Ala Ala Asn Ala Gly 
65                  70                  75                  80  


Thr Phe Leu Ser Ser Gln Pro Asp Ser Asp Ala Thr Arg Asn Phe Ile 
                85                  90                  95      


Thr Gly Met Ala Thr Ala Lys Ala Asn Gln Glu Ile Gln Glu Trp Leu 
            100                 105                 110         


Gly Lys Tyr Gly Thr Ala Arg Val Lys Leu Asn Val Asp Lys Asp Phe 
        115                 120                 125             


Ser Leu Lys Asp Ser Ser Leu Glu Met Leu Tyr Pro Ile Tyr Asp Thr 
    130                 135                 140                 


Pro Thr Asn Met Leu Phe Thr Gln Gly Ala Ile His Arg Thr Asp Asp 
145                 150                 155                 160 


Arg Thr Gln Ser Asn Ile Gly Phe Gly Trp Arg His Phe Ser Gly Asn 
                165                 170                 175     


Asp Trp Met Ala Gly Val Asn Thr Phe Ile Asp His Asp Leu Ser Arg 
            180                 185                 190         


Ser His Thr Arg Ile Gly Val Gly Ala Glu Tyr Trp Arg Asp Tyr Leu 
        195                 200                 205             


Lys Leu Ser Ala Asn Gly Tyr Ile Arg Ala Ser Gly Trp Lys Lys Ser 
    210                 215                 220                 


Pro Asp Ile Glu Asp Tyr Gln Glu Arg Pro Ala Asn Gly Trp Asp Ile 
225                 230                 235                 240 


Arg Ala Glu Gly Tyr Leu Pro Ala Trp Pro Gln Leu Gly Ala Ser Leu 
                245                 250                 255     


Met Tyr Glu Gln Tyr Tyr Gly Asp Glu Val Gly Leu Phe Gly Lys Asp 
            260                 265                 270         


Lys Arg Gln Lys Asp Pro His Ala Ile Ser Ala Glu Val Thr Tyr Thr 
        275                 280                 285             


Pro Val 
    290 


<210>  104
<211>  4257
<212>  DNA
<213>  Escherichia coli

<400>  104
atgtcacatt ataaaacagg tcataaacaa ccacgatttc gttattcagt tctggcccgc       60

tgcgtggcgt gggcaaatat ctctgttcag gttctttttc cactcgctgt cacctttacc      120

ccagtaatgg cggcacgtgc gcagcatgcg gttcagccac ggttgagcat gggaaatact      180

acggtaactg ctgataataa cgtggagaaa aatgtcgcgt cgtttgccgc aaatgccggg      240

acatttttaa gcagtcagcc agatagcgat gcgacacgta actttattac cggaatggcc      300

acagctaaag ctaaccagga aatacaggag tggctcggga aatatggtac tgcgcgcgtc      360

aaactgaatg tcgataaaga tttctcgctg aaggattctt cgctggaaat gctttatccg      420

atttatgata cgccgacaaa tatgttgttc actcaggggg caatacatcg tacagacgat      480

cgtactcagt caaatattgg ttttggctgg cgtcattttt caggaaatga ctggatggcg      540

ggggtgaata cttttatcga tcatgattta tcccgtagtc atacccgcat tggtgttggt      600

gcggaatact ggcgcgatta tctgaaactg agcgccaatg gttatattcg ggcttctggc      660

tggaaaaaat cgccggatat tgaggattat caggaacgcc cggcgaatgg ctgggatatt      720

cgtgctgagg gctatttacc cgcctggccg cagcttggcg caagcctgat gtatgaacag      780

tattatggcg atgaagtcgg gctgtttggt aaagataagc gccagaaaga cccgcatgct      840

atttctgccg aggtgaccta tacgccagtg cctcttctga cactgagcgc cgggcataag      900

cagggcaaga gtggtgagaa tgacactcgc tttggcctgg aagttaatta tcggattggc      960

gaacctctgg cgaaacaact cgatacagac agcattcgcg agcgtcgggt actggcaggc     1020

agccgctatg acctggttga gcgtaataac aacatcgttc ttgagtaccg caaatctgaa     1080

gtgatccgta ttgctctgcc tgaacgtatt gaaggtaagg gtggtcagac actttccctg     1140

gggcttgtgg tcagcaaagc aactcacgga ctgaaaaatg tgcagtggga agcgccgtca     1200

ttactggctg agggtggcaa aattaccggt cagggtagtc agtggcaagt aacgctcccg     1260

gcttatcgtc caggcaaaga caattattat gcgatttctg cggttgccta cgataacaaa     1320

ggcaatgcct caaaacgcgt gcagacagag gtggtcatta ccggagcagg tatgagcgcc     1380

gatcgcacgg cgttaacgct tgacggtcag agccgtattc aaatgcttgc taacggtaat     1440

gagcaaagac cgctggtgct gtctctgcgc gacgccgagg ggcagccagt cacgggcatg     1500

aaagatcaga tcaagactga actagccttc aaaccggctg gaaatattgt gactcgttcc     1560

ctgaaggcca ctaaatcaca ggcaaagcca acactgggtg agttcaccga aactgaagca     1620

ggggtgtatc agtctgtctt tactaccgga acgcagtcag gtgaggcaac gattactgtt     1680

agcgttgatg gcatgagcaa aaccgtcact gcagaactgc gggccacgat gatggatgtg     1740

gcaaactcca ccctgagcgc taacgagccg tcaggtgatg tggttgctga tggtcagcaa     1800

gcctatacgt tgacgttgac tgcggtggac tccgagggta atccggtgac gggagaagcc     1860

agccgcttgc gatttgttcc gcaagacact aatggtgtaa ccgttggtgc catttcggaa     1920

ataaaaccag gcgtttacag cgccacggtt tcttcgaccc gtgccggaaa cgttgttgtg     1980

cgtgctttca gcgagcagta tcagctgggc acattacaac aaacgctgaa gtttgttgcc     2040

ggtccgcttg atgcagcaca ttcgtccatc cccctgaatc ctgataaacc ggtggttggc     2100

ggtacagtta cggcaatctg gacggcaaaa gatgcctatg acaaccctgt gaccagcctc     2160

acgccggaag cgccgtcatt agcgggtgcc gctgctgtag gttctacggc atctggctgg     2220

acaaataatg gtgatgggac gtggactgcg cagattactc tcggctctac ggcgggtgaa     2280

ttagaagtta tgccgaagct aaatggacag gatgcggcag caaatgcggc aaaagtaacc     2340

gtggtggctg atgcgttatc ttcaaaccag tcgaaagtct ctgtcgcaga agatcacgta     2400

aaagccggcg aaagcacaac cgtgacgctt attgcaaaag atgcacatgg caacactatc     2460

agtggtcttt cgttgtcggc aagtttgacg gggaccgcct ctgaaggggc gaccgtttcc     2520

agttggaccg aaaaaggtga ctgttcctat gttgctacgt taactacagg cggaaagacg     2580

ggcgagcttc gtgtcatgcc gctcttcaac ggccagccag cagccaccga agccgcgcag     2640

ttgacggtca tcgccggaga gatgtcatca gcgaactcta cgcttgttgc ggacaataag     2700

gctccgaccg tcaaaatgac gacggaactc accttcaccg tgaaggatgc gtacgggaac     2760

ccggtcaccg ggctgaagcc agatgcacca gtgtttagcg gtgccgccag cacggggagt     2820

gagcgtcctt cagcaggaaa ctggacagag aaaggtaatg gggtctacgt ggcgacctta     2880

acgctgggat ctgccgcggg tcagttgtct gtgatgccgc gagtgaacgg ccaaaatgcc     2940

gttgctcagc cactggtgct gaacgttgca ggtgacgcat ctaaggctga gattcgtgat     3000

atgacagtga aggttaataa ccaactggct aatggacagt ctgctaacca gataaccctg     3060

accgtcgtgg acagctatgg taacccgttg caggggcaag aagttacgct gactttaccg     3120

cagggtgtga ccagcaagac ggggaataca gtaacaacca atgcggcagg gaaagtggac     3180

attgagctta tgtcaacggt tgcgggggaa cacagcatca cggcctcagt gaataatgct     3240

cagaagacgg ttacggtgaa attcaaggcg gatttcagta ccggtcaggc gaccctggag     3300

gttgatggca gcacgccaaa agtggcaaac gacaatgatg cctttacgct gacggcaacg     3360

gttaaggatc aatacggcaa ccttctgcct ggcgctgtgg tcgtctttaa tctgcctcgg     3420

ggcgtcaaac cgcttgcaga cggtaatatc atggtgaacg ccgacaagga gggtaaagcg     3480

gaactgaaag tggtctccgt gactgccgga acgtatgaga tcacggcgtc ggcaggaaat     3540

gaccagcctt cgaatgcgca gtctgtaacg tttgtggccg ataagactac ggcgaccatc     3600

tccagtattg aggtgattgg caaccgtgca gtggcggatg gcaaaaccaa acagacgtat     3660

aaagttacgg tgactgatgc caataacaac ctgttgaagg atagcgacgt gacgctgact     3720

gccagctcgg aaaatttagt tctggatcct aaagggacgg cgaaaactaa tgagcaagga     3780

caggctgttt tcaccggctc taccactatc gcagcgacat atacactcac ggcgaaagtg     3840

gaacaggcca acggtcaggt atcgacgaaa actgctgaat ctaaattcgt cgcggatgat     3900

aaaaacgcgg tgctcgccgc atctccagaa cgtgtagatt ctctggtggc ggacgggaag     3960

actactgcaa caatgacggt taccctgatg gcgggagtca atcccgtagg aggaagtatg     4020

tgggtcgaca ttgaggctcc ggaaggagtg acggagaagg attatcaatt cctgccgtcg     4080

aaggctgacc atttctcagg tgggaaaatc acgcgtacat ttagtaccag caagccaggt     4140

gtctatacgt tcacattcaa cgcactgacg tatggcgggt acgaaatgac gcctgtgaag     4200

gtgacaatta acgccgttgc tgcagagact gaaaatggcg aggaggagat gccataa        4257


<210>  105
<211>  35
<212>  DNA
<213>  Escherichia coli

<400>  105
catgccatgg aaatgggaaa tactacggta actgc                                  35


<210>  106
<211>  40
<212>  DNA
<213>  Escherichia coli

<400>  106
gagtcggccg cattaggttc gccaatccga taattaactt                             40


<210>  107
<211>  13
<212>  PRT
<213>  Escherichia coli

<400>  107

Asn Thr Ile Lys Thr Asp Thr Ser Gly Ile Pro Ala Ala 
1               5                   10              


<210>  108
<211>  12
<212>  PRT
<213>  Escherichia coli

<400>  108

Asp Ala Tyr Gln Arg Asp Gly Lys Tyr Pro Asp Phe 
1               5                   10          


<210>  109
<211>  1086
<212>  DNA
<213>  Escherichia coli

<400>  109
atgaataaga ttttatttat ttttacattg tttttctctt cagtactttt tacatttgct       60

gtatcggcag ataaaattcc cggagatgag aatataacta atatttttgg cccgcgtgac      120

aggaacgaat cttcccccaa acataatata ttaaatgact atattacagc atacagtgaa      180

agtcatactc tgtatgatag gatgattttt ttatgtttgt cttctcaaaa tacacttaat      240

ggagcatgtc caaccagtga gaatcctagc agttcatcgg tcagtggcga aacaaatata      300

acattacaat ttacggaaaa aagaagttta attaaaagag agctacaaat taaaggctat      360

aaacgattat tgttcaaagg tgctaactgc ccatcctacc taacacttaa ctcagctcat      420

tatacctgca atagaaactc ggcttcaggt gcaagtttat atttatatat tcctgctggc      480

gaactaaaaa atttaccttt tggtggtatc tgggatgcta ctctgaagtt aagagtaaaa      540

agacgatatg atcagaccta tggaacttac actataaata tcactgttaa attaactgat      600

aagggaaata ttcagatatg gttacctcag ttcaaaagtg acgctcgcgt cgatcttaac      660

ttgcgtccaa ctggtggggg cacatatatt ggaagaaatt ctgttgatat gtgcttttat      720

gatggatata gtactaacag cagctctttg gagctaagat ttcaggataa caatcctaaa      780

tctgatggga aattttatct aaggaaaata aatgatgaca ccaaagaaat tgcatatact      840

ttgtcacttc tcttggcggg taaaagttta actccaacaa atggaacgtc attaaatatt      900

gctgacgcag cttctctgga aataaactgg aatagaatta cagctgtcac catgccagaa      960

atcagtgttc cggtgttgtg ttggcctgga cgtttgcaat tggatgcaaa agtggaaaat     1020

cccgaggccg gacaatatat gggtaatatt aatattactt tcacaccaag tagtcaaaca     1080

ctctag                                                                1086


<210>  110
<211>  534
<212>  DNA
<213>  Escherichia coli

<400>  110
atgttgaaaa gaatatcgtg tataattttt gttttttttt cagggctgat ttatgctgcg       60

gaaattacaa atcagataga gctttcggta aaggttaata tatctaagcc tatgtgtaaa      120

cttaattctg gaacgcaaac aatagacttc ggcgattttg atgtactgga tattattacg      180

gagaacagaa aattaaatgg tcatgcgacc tttaaattta ctgagtgtag ttctgtcaaa      240

aacatgaaga taaaatttaa acaggcagga caaaatccag cgttagatat cgtaaacaat      300

tatatcccta atagtaaggg agatagaatg gcaaaggggg tagcggtaaa gcttctggat      360

gataaaaagc aagaaattca actgaacaag gaaatgaatg ttattgtgga ggagagtctg      420

acatttaaag atttaacgtt aaatgctcag gttatctcta ttaataaaga cggagaggga      480

gtttcacctg ggctacttca gaccgcaata ggaatggaga tatcctatga atga            534


<210>  111
<211>  1092
<212>  DNA
<213>  Escherichia coli

<400>  111
atgaaaaaga tatttatttt tttgtctatc atattttctg cggtggtcag tgccgggcga       60

tacccggaaa ctacagtagg taatctgacg aagagttttc aagcccctcg tcaggataga      120

agcgtacaat caccaatata taacatcttt acgaatcatg tggctggata tagtttgagt      180

cataacttat atgacaggat tgttttttta tgtacatcct cgtcgaatcc ggttaatggt      240

gcttgcccaa cccttggaac atctggagtt caatacggta ctacaaccat aaccttgcag      300

tttacagaaa aaagaagtct gataaaaaga aatattaatc ttgcaggtaa taagaaacca      360

atatgggaga atcagagttg cgacactagc aatctaatgg tgttgaattc gaagtcttgg      420

tcctgtgggc attacggaaa tgctaacgga acacttctaa atctgtatat ccctgcagga      480

gaaatcaaca aattgccttt tggagggata tgggaggcaa ctctgatctt acgcttatca      540

agatatggcg aagtcagtag cacccattac ggcaattata ccgtaaatat tacggttgat      600

ttaactgata aaggtaatat tcaggtatgg cttccagggt ttcacagcaa cccgcgtgta      660

gacctgaatc tgcaccctat cggtaattat aaatatagtg gtagtaattc actcgacatg      720

tgtttctatg atggatatag tacaaacagt gatagcatgg taataaagtt ccaggatgat      780

aatcctacct attcatctga atataatctt tataagatag ggggcactga aaaattacca      840

tatgctgttt cactgcttat gggagaaaaa atattttatc cagtgaatgg tcaatcattt      900

actatcaatg acagtagtgt actcgaaaca aactggaatc gagtaaccgc agttgctatg      960

ccggaagtta atgttccagt attatgctgg ccagcaagat tgctattaaa tgctgatgta     1020

aatgctcccg atgcaggaca gtattcagga cagatatata taacatttac acccagtgtc     1080

gaaaatttat ga                                                         1092


<210>  112
<211>  1092
<212>  DNA
<213>  Escherichia coli

<400>  112
atgaaaaaga tatttatttt tttgtctatc atattttctg cggtggtcag tgccgggcga       60

tacccggaaa ctacagtagg taatctgacg aagagttttc aagcccctcg tctggataga      120

agcgtacaat caccaatata taacatcttt acgaatcatg tggctggata tagtttgagt      180

catagattat atgacaggat tgtttttgta tgtacatcct cgtcgaatcc ggttaatggt      240

gcttgcccaa ccattggaac atctagagtt gaatacggta ctacaaccat aaccttgcag      300

tttacagaaa aaagaagtct gataaaaaga aatattaatc ttgcaggtaa taagaaacca      360

atatgggaga atcagagttg cgacactagc aatctaatgg tgttgaattc gaagtcttgg      420

tcctgtgggg ctctaggaaa tgctaacgga acacttctaa atctgtatat ccctgcagga      480

gaaatcaaca aattgccttt tggagggata tgggaggcaa ctctgatctt acgcttatca      540

agatatggcg aagtcagtag cacccattac ggcaattata ccgtaaatat tacggttgat      600

ttaactgata aaggtaatat tcaggtatgg cttccagggt ttcacagcaa cccgcgtgta      660

gacctgaatc tgcaccctat cggtaattat aaatatagtg gtagtaattc actcgacatg      720

tgtttctatg atggatatag tacaaacagt gatagcatgg taataaagtt ccaggatgat      780

aatcctacca attcatctga atataatctt tataagatag ggggcactga aaaattacca      840

tatgctgttt cactgcttat gggaggaaaa atattttatc cagtgaatgg tcaatcattt      900

actatcaatg acagtagtgt actcgaaaca aactggaatc gagtaaccgc agttgctatg      960

ccggaagtta atgttccagt attatgctgg ccagcaagat tgctattaaa tgctgatgta     1020

aatgctcccg atgcaggaca gtattcagga cagatatata taacatttac acccagtgtc     1080

gaaaatttat ga                                                         1092


<210>  113
<211>  872
<212>  DNA
<213>  Escherichia coli

<400>  113
atgtcacatt ataaaacagg tcataaacaa ccacgatttc gttattcagt tctggcccgc       60

tgcgtggcgt gggcaaatat ctctgttcag gttctttttc cactcgctgt cacctttacc      120

ccagtaatgg cggcacgtgc gcagcatgcg gttcagccac ggttgagcat gggaaatact      180

acggtaactg ctgataataa cgtggagaaa aatgtcgcgt cgtttgccgc aaatgccggg      240

acatttttaa gcagtcagcc agatagcgat gcgacacgta actttattac cggaatggcc      300

acagctaaag ctaaccagga aatacaggag tggctcggga aatatggtac tgcgcgcgtc      360

aaactgaatg tcgataaaga tttctcgctg aaggattctt cgctggaaat gctttatccg      420

atttatgata cgccgacaaa tatgttgttc actcaggggg caatacatcg tacagacgat      480

cgtactcagt caaatattgg ttttggctgg cgtcattttt caggaaatga ctggatggcg      540

ggggtgaata cttttatcga tcatgattta tcccgtagtc atacccgcat tggtgttggt      600

gcggaatact ggcgcgatta tctgaaactg agcgccaatg gttatattcg ggcttctggc      660

tggaaaaaat cgccggatat tgaggattat caggaacgcc cggcgaatgg ctgggatatt      720

cgtgctgagg gctatttacc cgcctggccg cagcttggcg caagcctgat gtatgaacag      780

tattatggcg atgaagtcgg gctgtttggt aaagataagc gccagaaaga cccgcatgct      840

atttctgccg aggtgaccta tacgccagtg cc                                    872


<210>  114
<211>  33
<212>  DNA
<213>  Escherichia coli

<400>  114
atatccatgg ctatgtgtaa acttaattct gga                                    33


<210>  115
<211>  30
<212>  DNA
<213>  Escherichia coli

<400>  115
atctcggccg ctattgcggt ctgaagtagc                                        30


<210>  116
<211>  33
<212>  DNA
<213>  Escherichia coli

<400>  116
ttttccatgg gcatgaaaaa gatatttatt ttt                                    33


<210>  117
<211>  30
<212>  DNA
<213>  Escherichia coli

<400>  117
ggtgcggccg ttatatatat ctgtcctgaa                                        30


<210>  118
<211>  33
<212>  DNA
<213>  Escherichia coli

<400>  118
gtcaccatgg atatgacagg attgtttttg tac                                    33


<210>  119
<211>  30
<212>  DNA
<213>  Escherichia coli

<400>  119
ggtgcggccg ttatatatat ctgtcctgaa                                        30


<210>  120
<211>  33
<212>  DNA
<213>  Escherichia coli

<400>  120
tttaccatgg taatggcggc acgtgcgcag cat                                    33


<210>  121
<211>  30
<212>  DNA
<213>  Escherichia coli

<400>  121
tttccggccg ttatctttac caaacagccc                                        30


