                               SEQUENCE LISTING

<110> MERRIMACK PHARMACEUTICALS, INC.
 
<120> METHODS FOR TREATING ER+, HER2-, HRG+ BREAST CANCER USING 
      COMBINATION THERAPIES COMPRISING AN ANTI-ERBB3 ANTIBODY

<130> MMJ-088PC

<140>
<141>

<150> 62/431,242
<151> 2016-12-07

<150> 62/356,127
<151> 2016-06-29

<150> 62/308,783
<151> 2016-03-15

<160> 13    

<170> PatentIn version 3.5

<210> 1
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 1
His Tyr Val Met Ala 
1               5   


<210> 2
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 2
Ser Ile Ser Ser Ser Gly Gly Trp Thr Leu Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 3
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 3
Gly Leu Lys Met Ala Thr Ile Phe Asp Tyr 
1               5                   10  


<210> 4
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 4
Thr Gly Thr Ser Ser Asp Val Gly Ser Tyr Asn Val Val Ser 
1               5                   10                  


<210> 5
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 5
Glu Val Ser Gln Arg Pro Ser 
1               5           


<210> 6
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 6
Cys Ser Tyr Ala Gly Ser Ser Ile Phe Val Ile 
1               5                   10      


<210> 7
<211> 445
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 7
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser His Tyr 
            20                  25                  30          


Val Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Ser Ser Gly Gly Trp Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Gly Leu Lys Met Ala Thr Ile Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys Val Glu 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu 
225                 230                 235                 240 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                245                 250                 255     


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln 
            260                 265                 270         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        275                 280                 285             


Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu 
    290                 295                 300                 


Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
305                 310                 315                 320 


Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                325                 330                 335     


Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            340                 345                 350         


Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        355                 360                 365             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    370                 375                 380                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly 
385                 390                 395                 400 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                405                 410                 415     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            420                 425                 430         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445 


<210> 8
<211> 217
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 8
Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Ser Tyr 
            20                  25                  30          


Asn Val Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Ile Ile Tyr Glu Val Ser Gln Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Cys Ser Tyr Ala Gly Ser 
                85                  90                  95      


Ser Ile Phe Val Ile Phe Gly Gly Gly Thr Lys Val Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Val Ser Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro Val 
145                 150                 155                 160 


Lys Val Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
            180                 185                 190         


His Arg Ser Tyr Ser Cys Arg Val Thr His Glu Gly Ser Thr Val Glu 
        195                 200                 205             


Lys Thr Val Ala Pro Ala Glu Cys Ser 
    210                 215         


<210> 9
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 9
gaggtgcagc tgctggagag cggcggaggg ctggtccagc caggcggcag cctgaggctg       60

tcctgcgccg ccagcggctt caccttcagc cactacgtga tggcctgggt gcggcaggcc      120

ccaggcaagg gcctggaatg ggtgtccagc atcagcagca gcggcggctg gaccctgtac      180

gccgacagcg tgaagggcag gttcaccatc agcagggaca acagcaagaa caccctgtac      240

ctgcagatga acagcctgag ggccgaggac accgccgtgt actactgcac caggggcctg      300

aagatggcca ccatcttcga ctactggggc cagggcaccc tggtgaccgt gagcagc         357


<210> 10
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 10
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser His Tyr 
            20                  25                  30          


Val Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Ser Ser Gly Gly Trp Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Gly Leu Lys Met Ala Thr Ile Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 11
<211> 333
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 11
cagtccgccc tgacccagcc cgccagcgtg agcggcagcc caggccagag catcaccatc       60

agctgcaccg gcaccagcag cgacgtgggc agctacaacg tggtgtcctg gtatcagcag      120

caccccggca aggcccccaa gctgatcatc tacgaggtgt cccagaggcc cagcggcgtg      180

agcaacaggt tcagcggcag caagagcggc aacaccgcca gcctgaccat cagcggcctg      240

cagaccgagg acgaggccga ctactactgc tgcagctacg ccggcagcag catcttcgtg      300

atcttcggcg gagggaccaa ggtgaccgtc cta                                   333


<210> 12
<211> 111
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 12
Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Ser Tyr 
            20                  25                  30          


Asn Val Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Ile Ile Tyr Glu Val Ser Gln Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Cys Ser Tyr Ala Gly Ser 
                85                  90                  95      


Ser Ile Phe Val Ile Phe Gly Gly Gly Thr Lys Val Thr Val Leu 
            100                 105                 110     


<210> 13
<211> 3093
<212> DNA
<213> Homo sapiens

<400> 13
gaggccaggg gagggtgcga aggaggcgcc tgcctccaac ctgcgggcgg gaggtgggtg       60

gctgcggggc aattgaaaaa gagccggcga ggagttcccc gaaacttgtt ggaactccgg      120

gctcgcgcgg aggccaggag ctgagcggcg gcggctgccg gacgatggga gcgtgagcag      180

gacggtgata acctctcccc gatcgggttg cgagggcgcc gggcagaggc caggacgcga      240

gccgccagcg gtgggaccca tcgacgactt cccggggcga caggagcagc cccgagagcc      300

agggcgagcg cccgttccag gtggccggac cgcccgccgc gtccgcgccg cgctccctgc      360

aggcaacggg agacgccccc gcgcagcgcg agcgcctcag cgcggccgct cgctctcccc      420

ctcgagggac aaacttttcc caaacccgat ccgagccctt ggaccaaact cgcctgcgcc      480

gagagccgtc cgcgtagagc gctccgtctc cggcgagatg tccgagcgca aagaaggcag      540

aggcaaaggg aagggcaaga agaaggagcg aggctccggc aagaagccgg agtccgcggc      600

gggcagccag agcccagcct tgcctccccg attgaaagag atgaaaagcc aggaatcggc      660

tgcaggttcc aaactagtcc ttcggtgtga aaccagttct gaatactcct ctctcagatt      720

caagtggttc aagaatggga atgaattgaa tcgaaaaaac aaaccacaaa atatcaagat      780

acaaaaaaag ccagggaagt cagaacttcg cattaacaaa gcatcactgg ctgattctgg      840

agagtatatg tgcaaagtga tcagcaaatt aggaaatgac agtgcctctg ccaatatcac      900

catcgtggaa tcaaacgaga tcatcactgg tatgccagcc tcaactgaag gagcatatgt      960

gtcttcagag tctcccatta gaatatcagt atccacagaa ggagcaaata cttcttcatc     1020

tacatctaca tccaccactg ggacaagcca tcttgtaaaa tgtgcggaga aggagaaaac     1080

tttctgtgtg aatggagggg agtgcttcat ggtgaaagac ctttcaaacc cctcgagata     1140

cttgtgcaag tgcccaaatg agtttactgg tgatcgctgc caaaactacg taatggccag     1200

cttctacaag catcttggga ttgaatttat ggaggcggag gagctgtacc agaagagagt     1260

gctgaccata accggcatct gcatcgccct ccttgtggtc ggcatcatgt gtgtggtggc     1320

ctactgcaaa accaagaaac agcggaaaaa gctgcatgac cgtcttcggc agagccttcg     1380

gtctgaacga aacaatatga tgaacattgc caatgggcct caccatccta acccaccccc     1440

cgagaatgtc cagctggtga atcaatacgt atctaaaaac gtcatctcca gtgagcatat     1500

tgttgagaga gaagcagaga catccttttc caccagtcac tatacttcca cagcccatca     1560

ctccactact gtcacccaga ctcctagcca cagctggagc aacggacaca ctgaaagcat     1620

cctttccgaa agccactctg taatcgtgat gtcatccgta gaaaacagta ggcacagcag     1680

cccaactggg ggcccaagag gacgtcttaa tggcacagga ggccctcgtg aatgtaacag     1740

cttcctcagg catgccagag aaacccctga ttcctaccga gactctcctc atagtgaaag     1800

gtatgtgtca gccatgacca ccccggctcg tatgtcacct gtagatttcc acacgccaag     1860

ctcccccaaa tcgccccctt cggaaatgtc tccacccgtg tccagcatga cggtgtccat     1920

gccttccatg gcggtcagcc ccttcatgga agaagagaga cctctacttc tcgtgacacc     1980

accaaggctg cgggagaaga agtttgacca tcaccctcag cagttcagct ccttccacca     2040

caaccccgcg catgacagta acagcctccc tgctagcccc ttgaggatag tggaggatga     2100

ggagtatgaa acgacccaag agtacgagcc agcccaagag cctgttaaga aactcgccaa     2160

tagccggcgg gccaaaagaa ccaagcccaa tggccacatt gctaacagat tggaagtgga     2220

cagcaacaca agctcccaga gcagtaactc agagagtgaa acagaagatg aaagagtagg     2280

tgaagatacg cctttcctgg gcatacagaa ccccctggca gccagtcttg aggcaacacc     2340

tgccttccgc ctggctgaca gcaggactaa cccagcaggc cgcttctcga cacaggaaga     2400

aatccaggcc aggctgtcta gtgtaattgc taaccaagac cctattgctg tataaaacct     2460

aaataaacac atagattcac ctgtaaaact ttattttata taataaagta ttccacctta     2520

aattaaacaa tttattttat tttagcagtt ctgcaaatag aaaacaggaa aaaaactttt     2580

ataaattaaa tatatgtatg taaaaatgtg ttatgtgcca tatgtagcaa ttttttacag     2640

tatttcaaaa cgagaaagat atcaatggtg cctttatgtt atgttatgtc gagagcaagt     2700

tttgtacagt tacagtgatt gcttttccac agtatttctg caaaacctct catagattca     2760

gtttttgctg gcttcttgtg cattgcatta tgatgttgac tggatgtatg atttgcaaga     2820

cttgcaactg tccctctgtt tgcttgtagt agcacccgat cagtatgtct tgtaatggca     2880

catccatcca gatatgcctc tcttgtgtat gaagttttct ttgctttcag aatatgaaat     2940

gagttgtgtc tactctgcca gccaaaggtt tgcctcattg ggctctgaga taatagtaga     3000

tccaacagca tgctactatt aaatacagca agaaactgca ttaagtaatg ttaaatatta     3060

ggaagaaagt aatactgtga tttaaaaaaa act                                  3093


