                         SEQUENCE LISTING

<110>  BAYLOR COLLEGE OF MEDICINE
 
<120>  Tc24-C4, A CHAGAS DISEASE VACCINE ANTIGEN WITH IMPROVED STABILITY
        AND DECREASED AGGREGATION

<130>  BAYM.P0173WO-11702018

<150>  62/308,054
<151>  2016-03-14

<160>  5     

<170>  PatentIn version 3.5

<210>  1
<211>  633
<212>  DNA
<213>  Escherichia coli

<400>  1
atgggtgcta gcggctccaa aggttcaacg agtgataaag gtctggcttc ggataaagat       60

ggtaaaaatg ctaaagatcg caaagaagcg tgggaacgta ttcgccaggc catcccgcgt      120

gaaaaaaccg cggaagccaa acaacgtcgc atcgaactgt tcaaaaaatt cgataaaaac      180

gaaacgggca aactgagcta tgacgaagtg catagcggta gcctggaagt tctgaaactg      240

gatgaattca ccccgcgtgt ccgcgatatc acgaaacgtg cctttgacaa agcacgcgct      300

ctgggcagca aactggaaaa caaaggttct gaagatttcg tggaattcct ggaatttcgt      360

ctgatgctga gctatattta cgactttttc gaactgaccg ttatgttcga tgaaatcgac      420

gcaagcggca acatgctggt cgatgaagaa gaactgaaac gcgcggtgcc gaaactggaa      480

gcatggggtg ctaaagttga agatccggcg gccctgttta aagaactgga caaaaatggc      540

accggtagtg ttacgttcga tgaatttgca gcttgggcgt ccgccgtcaa actggatgca      600

gacggcgacc cggataatgt cccggaatca gcc                                   633


<210>  2
<211>  211
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  2

Met Gly Ala Ser Gly Ser Lys Gly Ser Thr Ser Asp Lys Gly Leu Ala 
1               5                   10                  15      


Ser Asp Lys Asp Gly Lys Asn Ala Lys Asp Arg Lys Glu Ala Trp Glu 
            20                  25                  30          


Arg Ile Arg Gln Ala Ile Pro Arg Glu Lys Thr Ala Glu Ala Lys Gln 
        35                  40                  45              


Arg Arg Ile Glu Leu Phe Lys Lys Phe Asp Lys Asn Glu Thr Gly Lys 
    50                  55                  60                  


Leu Ser Tyr Asp Glu Val His Ser Gly Ser Leu Glu Val Leu Lys Leu 
65                  70                  75                  80  


Asp Glu Phe Thr Pro Arg Val Arg Asp Ile Thr Lys Arg Ala Phe Asp 
                85                  90                  95      


Lys Ala Arg Ala Leu Gly Ser Lys Leu Glu Asn Lys Gly Ser Glu Asp 
            100                 105                 110         


Phe Val Glu Phe Leu Glu Phe Arg Leu Met Leu Ser Tyr Ile Tyr Asp 
        115                 120                 125             


Phe Phe Glu Leu Thr Val Met Phe Asp Glu Ile Asp Ala Ser Gly Asn 
    130                 135                 140                 


Met Leu Val Asp Glu Glu Glu Leu Lys Arg Ala Val Pro Lys Leu Glu 
145                 150                 155                 160 


Ala Trp Gly Ala Lys Val Glu Asp Pro Ala Ala Leu Phe Lys Glu Leu 
                165                 170                 175     


Asp Lys Asn Gly Thr Gly Ser Val Thr Phe Asp Glu Phe Ala Ala Trp 
            180                 185                 190         


Ala Ser Ala Val Lys Leu Asp Ala Asp Gly Asp Pro Asp Asn Val Pro 
        195                 200                 205             


Glu Ser Ala 
    210     


<210>  3
<211>  633
<212>  DNA
<213>  Trypanosoma cruzi

<400>  3
atgggtgctt gtgggtcgaa gggctcgacg agcgacaagg ggttggcgag cgataaggac       60

ggcaagaacg ccaaggaccg caaggaagcg tgggagcgca ttcgccaggc gattcctcgt      120

gagaagaccg ccgaggcaaa acagcgccgc atcgagctat tcaagaagtt cgacaagaac      180

gagactggga agctgtgcta cgatgaggtg cacagcggct gcctcgaggt gctgaagttg      240

gacgagttca cgccgcgagt gcgcgacatc acgaagcgtg cgttcgacaa ggcgagggcc      300

ctgggcagca agctggagaa caagggctcc gaggactttg ttgaatttct ggagttccgt      360

ctgatgctgt gctacatcta cgacttcttc gagctgacgg tgatgttcga cgagattgac      420

gcctccggca acatgctggt cgacgaggag gagctcaagc gcgccgtgcc caagcttgag      480

gcgtggggcg ccaaggtcga ggatcccgcg gcgctgttca aggagctcga taagaatggc      540

actgggtccg tgacgttcga cgagtttgca gcgtgggctt ctgcagtcaa actggacgcc      600

gacggcgacc cggacaacgt gccggagagc gcg                                   633


<210>  4
<211>  211
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  4

Met Gly Ala Cys Gly Ser Lys Gly Ser Thr Ser Asp Lys Gly Leu Ala 
1               5                   10                  15      


Ser Asp Lys Asp Gly Lys Asn Ala Lys Asp Arg Lys Glu Ala Trp Glu 
            20                  25                  30          


Arg Ile Arg Gln Ala Ile Pro Arg Glu Lys Thr Ala Glu Ala Lys Gln 
        35                  40                  45              


Arg Arg Ile Glu Leu Phe Lys Lys Phe Asp Lys Asn Glu Thr Gly Lys 
    50                  55                  60                  


Leu Cys Tyr Asp Glu Val His Ser Gly Cys Leu Glu Val Leu Lys Leu 
65                  70                  75                  80  


Asp Glu Phe Thr Pro Arg Val Arg Asp Ile Thr Lys Arg Ala Phe Asp 
                85                  90                  95      


Lys Ala Arg Ala Leu Gly Ser Lys Leu Glu Asn Lys Gly Ser Glu Asp 
            100                 105                 110         


Phe Val Glu Phe Leu Glu Phe Arg Leu Met Leu Cys Tyr Ile Tyr Asp 
        115                 120                 125             


Phe Phe Glu Leu Thr Val Met Phe Asp Glu Ile Asp Ala Ser Gly Asn 
    130                 135                 140                 


Met Leu Val Asp Glu Glu Glu Leu Lys Arg Ala Val Pro Lys Leu Glu 
145                 150                 155                 160 


Ala Trp Gly Ala Lys Val Glu Asp Pro Ala Ala Leu Phe Lys Glu Leu 
                165                 170                 175     


Asp Lys Asn Gly Thr Gly Ser Val Thr Phe Asp Glu Phe Ala Ala Trp 
            180                 185                 190         


Ala Ser Ala Val Lys Leu Asp Ala Asp Gly Asp Pro Asp Asn Val Pro 
        195                 200                 205             


Glu Ser Ala 
    210     


<210>  5
<211>  633
<212>  DNA
<213>  Escherichia coli

<400>  5
atgggtgctt gtggctccaa aggttcaacg agtgataaag gtctggcttc ggataaagat       60

ggtaaaaatg ctaaagatcg caaagaagcg tgggaacgta ttcgccaggc catcccgcgt      120

gaaaaaaccg cggaagccaa acaacgtcgc atcgaactgt tcaaaaaatt cgataaaaac      180

gaaacgggca aactgtgcta tgacgaagtg catagcggtt gtctggaagt tctgaaactg      240

gatgaattca ccccgcgtgt ccgcgatatc acgaaacgtg cctttgacaa agcacgcgct      300

ctgggcagca aactggaaaa caaaggttct gaagatttcg tggaattcct ggaatttcgt      360

ctgatgctgt gctatattta cgactttttc gaactgaccg ttatgttcga tgaaatcgac      420

gcaagcggca acatgctggt cgatgaagaa gaactgaaac gcgcggtgcc gaaactggaa      480

gcatggggtg ctaaagttga agatccggcg gccctgttta aagaactgga caaaaatggc      540

accggtagtg ttacgttcga tgaatttgca gcttgggcgt ccgccgtcaa actggatgca      600

gacggcgacc cggataatgt cccggaatca gcc                                   633


