                         SEQUENCE LISTING

<110>  Cancer Research Technology Limited
       The University of Birmingham
       Cell Therapy Catapult Limited
 
<120>  Chimeric Antigen Receptor

<130>  16/0002/JA

<160>  232   

<170>  PatentIn version 3.5

<210>  1
<211>  490
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Arg Pro Ala Phe Ala Leu Cys Leu Leu Trp Gln Ala Leu Trp Pro 
1               5                   10                  15      


Gly Pro Gly Gly Gly Glu His Pro Thr Ala Asp Arg Ala Gly Cys Ser 
            20                  25                  30          


Ala Ser Gly Ala Cys Tyr Ser Leu His His Ala Thr Met Lys Arg Gln 
        35                  40                  45              


Ala Ala Glu Glu Ala Cys Ile Leu Arg Gly Gly Ala Leu Ser Thr Val 
    50                  55                  60                  


Arg Ala Gly Ala Glu Leu Arg Ala Val Leu Ala Leu Leu Arg Ala Gly 
65                  70                  75                  80  


Pro Gly Pro Gly Gly Gly Ser Lys Asp Leu Leu Phe Trp Val Ala Leu 
                85                  90                  95      


Glu Arg Arg Arg Ser His Cys Thr Leu Glu Asn Glu Pro Leu Arg Gly 
            100                 105                 110         


Phe Ser Trp Leu Ser Ser Asp Pro Gly Gly Leu Glu Ser Asp Thr Leu 
        115                 120                 125             


Gln Trp Val Glu Glu Pro Gln Arg Ser Cys Thr Ala Arg Arg Cys Ala 
    130                 135                 140                 


Val Leu Gln Ala Thr Gly Gly Val Glu Pro Ala Gly Trp Lys Glu Met 
145                 150                 155                 160 


Arg Cys His Leu Arg Ala Asn Gly Tyr Leu Cys Lys Tyr Gln Phe Glu 
                165                 170                 175     


Val Leu Cys Pro Ala Pro Arg Pro Gly Ala Ala Ser Asn Leu Ser Tyr 
            180                 185                 190         


Arg Ala Pro Phe Gln Leu His Ser Ala Ala Leu Asp Phe Ser Pro Pro 
        195                 200                 205             


Gly Thr Glu Val Ser Ala Leu Cys Arg Gly Gln Leu Pro Ile Ser Val 
    210                 215                 220                 


Thr Cys Ile Ala Asp Glu Ile Gly Ala Arg Trp Asp Lys Leu Ser Gly 
225                 230                 235                 240 


Asp Val Leu Cys Pro Cys Pro Gly Arg Tyr Leu Arg Ala Gly Lys Cys 
                245                 250                 255     


Ala Glu Leu Pro Asn Cys Leu Asp Asp Leu Gly Gly Phe Ala Cys Glu 
            260                 265                 270         


Cys Ala Thr Gly Phe Glu Leu Gly Lys Asp Gly Arg Ser Cys Val Thr 
        275                 280                 285             


Ser Gly Glu Gly Gln Pro Thr Leu Gly Gly Thr Gly Val Pro Thr Arg 
    290                 295                 300                 


Arg Pro Pro Ala Thr Ala Thr Ser Pro Val Pro Gln Arg Thr Trp Pro 
305                 310                 315                 320 


Ile Arg Val Asp Glu Lys Leu Gly Glu Thr Pro Leu Val Pro Glu Gln 
                325                 330                 335     


Asp Asn Ser Val Thr Ser Ile Pro Glu Ile Pro Arg Trp Gly Ser Gln 
            340                 345                 350         


Ser Thr Met Ser Thr Leu Gln Met Ser Leu Gln Ala Glu Ser Lys Ala 
        355                 360                 365             


Thr Ile Thr Pro Ser Gly Ser Val Ile Ser Lys Phe Asn Ser Thr Thr 
    370                 375                 380                 


Ser Ser Ala Thr Pro Gln Ala Phe Asp Ser Ser Ser Ala Val Val Phe 
385                 390                 395                 400 


Ile Phe Val Ser Thr Ala Val Val Val Leu Val Ile Leu Thr Met Thr 
                405                 410                 415     


Val Leu Gly Leu Val Lys Leu Cys Phe His Glu Ser Pro Ser Ser Gln 
            420                 425                 430         


Pro Arg Lys Glu Ser Met Gly Pro Pro Gly Leu Glu Ser Asp Pro Glu 
        435                 440                 445             


Pro Ala Ala Leu Gly Ser Ser Ser Ala His Cys Thr Asn Asn Gly Val 
    450                 455                 460                 


Lys Val Gly Asp Cys Asp Leu Arg Asp Arg Ala Glu Gly Ala Leu Leu 
465                 470                 475                 480 


Ala Glu Ser Pro Leu Gly Ser Ser Asp Ala 
                485                 490 


<210>  2
<211>  2256
<212>  DNA
<213>  Homo sapiens

<400>  2
ctcctcttgc tctaagcagg gtgtttgacc ttctagtcga ctgcgtcccc tgtacccggc       60

gccagctgtg ttcctgaccc cagaataact cagggctgca ccgggcctgg cagcgctccg      120

cacacatttc ctgtcgcggc ctaagggaaa ctgttggccg ctgggcccgc ggggggattc      180

ttggcagttg gggggtccgt cgggagcgag ggcggagggg aagggagggg gaaccgggtt      240

ggggaagcca gctgtagagg gcggtgaccg cgctccagac acagctctgc gtcctcgagc      300

gggacagatc caagttggga gcagctctgc gtgcggggcc tcagagaatg aggccggcgt      360

tcgccctgtg cctcctctgg caggcgctct ggcccgggcc gggcggcggc gaacacccca      420

ctgccgaccg tgctggctgc tcggcctcgg gggcctgcta cagcctgcac cacgctacca      480

tgaagcggca ggcggccgag gaggcctgca tcctgcgagg tggggcgctc agcaccgtgc      540

gtgcgggcgc cgagctgcgc gctgtgctcg cgctcctgcg ggcaggccca gggcccggag      600

ggggctccaa agacctgctg ttctgggtcg cactggagcg caggcgttcc cactgcaccc      660

tggagaacga gcctttgcgg ggtttctcct ggctgtcctc cgaccccggc ggtctcgaaa      720

gcgacacgct gcagtgggtg gaggagcccc aacgctcctg caccgcgcgg agatgcgcgg      780

tactccaggc caccggtggg gtcgagcccg caggctggaa ggagatgcga tgccacctgc      840

gcgccaacgg ctacctgtgc aagtaccagt ttgaggtctt gtgtcctgcg ccgcgccccg      900

gggccgcctc taacttgagc tatcgcgcgc ccttccagct gcacagcgcc gctctggact      960

tcagtccacc tgggaccgag gtgagtgcgc tctgccgggg acagctcccg atctcagtta     1020

cttgcatcgc ggacgaaatc ggcgctcgct gggacaaact ctcgggcgat gtgttgtgtc     1080

cctgccccgg gaggtacctc cgtgctggca aatgcgcaga gctccctaac tgcctagacg     1140

acttgggagg ctttgcctgc gaatgtgcta cgggcttcga gctggggaag gacggccgct     1200

cttgtgtgac cagtggggaa ggacagccga cccttggggg gaccggggtg cccaccaggc     1260

gcccgccggc cactgcaacc agccccgtgc cgcagagaac atggccaatc agggtcgacg     1320

agaagctggg agagacacca cttgtccctg aacaagacaa ttcagtaaca tctattcctg     1380

agattcctcg atggggatca cagagcacga tgtctaccct tcaaatgtcc cttcaagccg     1440

agtcaaaggc cactatcacc ccatcaggga gcgtgatttc caagtttaat tctacgactt     1500

cctctgccac tcctcaggct ttcgactcct cctctgccgt ggtcttcata tttgtgagca     1560

cagcagtagt agtgttggtg atcttgacca tgacagtact ggggcttgtc aagctctgct     1620

ttcacgaaag cccctcttcc cagccaagga aggagtctat gggcccgccg ggcctggaga     1680

gtgatcctga gcccgctgct ttgggctcca gttctgcaca ttgcacaaac aatggggtga     1740

aagtcgggga ctgtgatctg cgggacagag cagagggtgc cttgctggcg gagtcccctc     1800

ttggctctag tgatgcatag ggaaacaggg gacatgggca ctcctgtgaa cagtttttca     1860

cttttgatga aacggggaac caagaggaac ttacttgtgt aactgacaat ttctgcagaa     1920

atcccccttc ctctaaattc cctttactcc actgaggagc taaatcagaa ctgcacactc     1980

cttccctgat gatagaggaa gtggaagtgc ctttaggatg gtgatactgg gggaccgggt     2040

agtgctgggg agagatattt tcttatgttt attcggagaa tttggagaag tgattgaact     2100

tttcaagaca ttggaaacaa atagaacaca atataattta cattaaaaaa taatttctac     2160

caaaatggaa aggaaatgtt ctatgttgtt caggctagga gtatattggt tcgaaatccc     2220

agggaaaaaa ataaaaataa aaaattaaag gattgt                               2256


<210>  3
<211>  1473
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CLEC14A cds

<400>  3
atgaggccgg cgttcgccct gtgcctcctc tggcaggcgc tctggcccgg gccgggcggc       60

ggcgaacacc ccactgccga ccgtgctggc tgctcggcct cgggggcctg ctacagcctg      120

caccacgcta ccatgaagcg gcaggcggcc gaggaggcct gcatcctgcg aggtggggcg      180

ctcagcaccg tgcgtgcggg cgccgagctg cgcgctgtgc tcgcgctcct gcgggcaggc      240

ccagggcccg gagggggctc caaagacctg ctgttctggg tcgcactgga gcgcaggcgt      300

tcccactgca ccctggagaa cgagcctttg cggggtttct cctggctgtc ctccgacccc      360

ggcggtctcg aaagcgacac gctgcagtgg gtggaggagc cccaacgctc ctgcaccgcg      420

cggagatgcg cggtactcca ggccaccggt ggggtcgagc ccgcaggctg gaaggagatg      480

cgatgccacc tgcgcgccaa cggctacctg tgcaagtacc agtttgaggt cttgtgtcct      540

gcgccgcgcc ccggggccgc ctctaacttg agctatcgcg cgcccttcca gctgcacagc      600

gccgctctgg acttcagtcc acctgggacc gaggtgagtg cgctctgccg gggacagctc      660

ccgatctcag ttacttgcat cgcggacgaa atcggcgctc gctgggacaa actctcgggc      720

gatgtgttgt gtccctgccc cgggaggtac ctccgtgctg gcaaatgcgc agagctccct      780

aactgcctag acgacttggg aggctttgcc tgcgaatgtg ctacgggctt cgagctgggg      840

aaggacggcc gctcttgtgt gaccagtggg gaaggacagc cgacccttgg ggggaccggg      900

gtgcccacca ggcgcccgcc ggccactgca accagccccg tgccgcagag aacatggcca      960

atcagggtcg acgagaagct gggagagaca ccacttgtcc ctgaacaaga caattcagta     1020

acatctattc ctgagattcc tcgatgggga tcacagagca cgatgtctac ccttcaaatg     1080

tcccttcaag ccgagtcaaa ggccactatc accccatcag ggagcgtgat ttccaagttt     1140

aattctacga cttcctctgc cactcctcag gctttcgact cctcctctgc cgtggtcttc     1200

atatttgtga gcacagcagt agtagtgttg gtgatcttga ccatgacagt actggggctt     1260

gtcaagctct gctttcacga aagcccctct tcccagccaa ggaaggagtc tatgggcccg     1320

ccgggcctgg agagtgatcc tgagcccgct gctttgggct ccagttctgc acattgcaca     1380

aacaatgggg tgaaagtcgg ggactgtgat ctgcgggaca gagcagaggg tgccttgctg     1440

gcggagtccc ctcttggctc tagtgatgca tag                                  1473


<210>  4
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human CLEC14A forward primer

<400>  4
tagtaggaat tcgagagaat gaggccggcg ttcgccctg                              39


<210>  5
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  human CLEC14A reverse primer

<400>  5
agaaccgcgg ccgctggagg agtcgaaagc ctgaggagt                              39


<210>  6
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Murine CLEC14A forward primer

<400>  6
tagtaggaat tcgagagaat gaggccagcg cttgccctg                              39


<210>  7
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Murine CLEC14A reverse primer

<400>  7
ctactagcgg ccgctcgtgg aagaggtgtc gaaagt                                 36


<210>  8
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  human CLEC14A forward primer

<400>  8
tagtagttaa ttaagagaga atgaggccgg cgttc                                  35


<210>  9
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Murine CLEC14A forward primer

<400>  9
tagtagttaa ttaagagaga atgaggccag cgctt                                  35


<210>  10
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human Fc reverse primer

<400>  10
ctactagttt aaactcattt acccggagac aggga                                  35


<210>  11
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MMRN2 forward primer

<400>  11
ccggaccggt caggcttcca gtactagcc                                         29


<210>  12
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MMRN2 reverse primer

<400>  12
cggggtaccg gtcttaaaca tcaggaagc                                         29


<210>  13
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5'UTR forward primer

<400>  13
ttccttttcc agggtttgtg                                                   20


<210>  14
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5'UTR reverse primer

<400>  14
gcctacaagg tggcttgaat                                                   20


<210>  15
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDS forward primer

<400>  15
aagctgtgct cctgctcttg                                                   20


<210>  16
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDS reverse primer

<400>  16
tcctgagtgc actgtgagat g                                                 21


<210>  17
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3'UTR forward primer

<400>  17
ctgtagaggg cggtgacttt                                                   20


<210>  18
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3' UTR reverse primer

<400>  18
agctgctccc aagtcctct                                                    19


<210>  19
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mACTB forward primer

<400>  19
ctaaggccaa ccgtgaaaag                                                   20


<210>  20
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mACTB reverse primer

<400>  20
accagaggca tacagggaca                                                   20


<210>  21
<211>  39
<212>  PRT
<213>  Unknown

<220>
<223>  N-terminal portion of CD141

<400>  21

Met Leu Gly Val Leu Val Leu Gly Ala Leu Ala Leu Ala Gly Leu Gly 
1               5                   10                  15      


Phe Pro Ala Pro Ala Glu Pro Gln Pro Gly Gly Ser Gln Cys Val Glu 
            20                  25                  30          


His Asp Cys Phe Ala Leu Tyr 
        35                  


<210>  22
<211>  12
<212>  PRT
<213>  Unknown

<220>
<223>  Residues 97-108 of CD141

<400>  22

Gln Leu Pro Pro Gly Cys Gly Asp Pro Lys Arg Leu 
1               5                   10          


<210>  23
<211>  20
<212>  PRT
<213>  Unknown

<220>
<223>  Residues 122-142 of CD141

<400>  23

Thr Ser Tyr Ser Arg Trp Ala Arg Leu Asp Leu Asn Gly Ala Pro Leu 
1               5                   10                  15      


Cys Gly Pro Leu 
            20  


<210>  24
<211>  12
<212>  PRT
<213>  Unknown

<220>
<223>  Residues 97-108 human CLEC14A

<400>  24

Glu Arg Arg Arg Ser Cys His Thr Leu Glu Asn Glu 
1               5                   10          


<210>  25
<211>  169
<212>  PRT
<213>  Unknown

<220>
<223>  CTLD of CD141

<400>  25

Met Leu Gly Val Leu Val Leu Gly Ala Leu Ala Leu Ala Gly Leu Gly 
1               5                   10                  15      


Phe Pro Ala Pro Ala Glu Pro Gln Pro Gly Gly Ser Gln Cys Val Glu 
            20                  25                  30          


His Asp Cys Phe Ala Leu Tyr Pro Gly Pro Ala Thr Phe Leu Asn Ala 
        35                  40                  45              


Ser Gln Ile Cys Asp Gly Leu Arg Gly His Leu Met Thr Val Arg Ser 
    50                  55                  60                  


Ser Val Ala Ala Asp Val Ile Ser Leu Leu Leu Asn Gly Asp Gly Gly 
65                  70                  75                  80  


Val Gly Arg Arg Arg Leu Trp Ile Gly Leu Gln Leu Pro Pro Gly Cys 
                85                  90                  95      


Gly Asp Pro Lys Arg Leu Gly Pro Leu Arg Gly Phe Gln Trp Val Thr 
            100                 105                 110         


Gly Asp Asn Asn Thr Ser Tyr Ser Arg Trp Ala Arg Leu Asp Leu Asn 
        115                 120                 125             


Gly Ala Pro Leu Cys Gly Pro Leu Cys Val Ala Val Ser Ala Ala Glu 
    130                 135                 140                 


Ala Thr Val Pro Ser Glu Pro Ile Trp Glu Glu Gln Gln Cys Glu Val 
145                 150                 155                 160 


Lys Ala Asp Gly Phe Leu Cys Glu Phe 
                165                 


<210>  26
<211>  740
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimera of CLEC14A, CD141 and GFP

<400>  26

Met Leu Gly Val Leu Val Leu Gly Ala Leu Ala Leu Ala Gly Leu Gly 
1               5                   10                  15      


Phe Pro Ala Pro Ala Glu Pro Gln Pro Gly Gly Ser Gln Cys Val Glu 
            20                  25                  30          


His Asp Cys Phe Ala Leu Tyr Pro Gly Pro Ala Thr Phe Leu Asn Ala 
        35                  40                  45              


Ser Gln Ile Cys Asp Gly Leu Arg Gly His Leu Met Thr Val Arg Ser 
    50                  55                  60                  


Ser Val Ala Ala Asp Val Ile Ser Leu Leu Leu Asn Gly Asp Gly Gly 
65                  70                  75                  80  


Val Gly Arg Arg Arg Leu Trp Ile Gly Leu Gln Leu Pro Pro Gly Cys 
                85                  90                  95      


Gly Asp Pro Lys Arg Leu Gly Pro Leu Arg Gly Phe Gln Trp Val Thr 
            100                 105                 110         


Gly Asp Asn Asn Thr Ser Tyr Ser Arg Trp Ala Arg Leu Asp Leu Asn 
        115                 120                 125             


Gly Ala Pro Leu Cys Gly Pro Leu Cys Val Ala Val Ser Ala Ala Glu 
    130                 135                 140                 


Ala Thr Val Pro Ser Glu Pro Ile Trp Glu Glu Gln Gln Cys Glu Val 
145                 150                 155                 160 


Lys Ala Asp Gly Phe Leu Cys Glu Phe Gln Phe Glu Val Leu Cys Pro 
                165                 170                 175     


Ala Pro Arg Pro Gly Ala Ala Ser Asn Leu Ser Tyr Arg Ala Pro Phe 
            180                 185                 190         


Gln Leu His Ser Ala Ala Leu Asp Phe Ser Pro Pro Gly Thr Glu Val 
        195                 200                 205             


Ser Ala Leu Cys Arg Gly Gln Leu Pro Ile Ser Val Thr Cys Ile Ala 
    210                 215                 220                 


Asp Glu Ile Gly Ala Arg Trp Asp Lys Leu Ser Gly Asp Val Leu Cys 
225                 230                 235                 240 


Pro Cys Pro Gly Arg Tyr Leu Arg Ala Gly Lys Cys Ala Glu Leu Pro 
                245                 250                 255     


Asn Cys Leu Asp Asp Leu Gly Gly Phe Ala Cys Glu Cys Ala Thr Gly 
            260                 265                 270         


Phe Glu Leu Gly Lys Asp Gly Arg Ser Cys Val Thr Ser Gly Glu Gly 
        275                 280                 285             


Gln Pro Thr Leu Gly Gly Thr Gly Val Pro Thr Arg Arg Pro Pro Ala 
    290                 295                 300                 


Thr Ala Thr Ser Pro Val Pro Gln Arg Thr Trp Pro Ile Arg Val Asp 
305                 310                 315                 320 


Glu Lys Leu Gly Glu Thr Pro Leu Val Pro Glu Gln Asp Asn Ser Val 
                325                 330                 335     


Thr Ser Ile Pro Glu Ile Pro Arg Trp Gly Ser Gln Ser Thr Met Ser 
            340                 345                 350         


Thr Leu Gln Met Ser Leu Gln Ala Glu Ser Lys Ala Thr Ile Thr Pro 
        355                 360                 365             


Ser Gly Ser Val Ile Ser Lys Phe Asn Ser Thr Thr Ser Ser Ala Thr 
    370                 375                 380                 


Pro Gln Ala Phe Asp Ser Ser Ser Ala Val Val Phe Ile Phe Val Ser 
385                 390                 395                 400 


Thr Ala Val Val Val Leu Val Ile Leu Thr Met Thr Val Leu Gly Leu 
                405                 410                 415     


Val Lys Leu Cys Phe His Glu Ser Pro Ser Ser Gln Pro Arg Lys Glu 
            420                 425                 430         


Ser Met Gly Pro Pro Gly Leu Glu Ser Asp Pro Glu Pro Ala Ala Leu 
        435                 440                 445             


Gly Ser Ser Ser Ala His Cys Thr Asn Asn Gly Val Lys Val Gly Asp 
    450                 455                 460                 


Cys Asp Leu Arg Asp Arg Ala Glu Gly Ala Leu Leu Ala Glu Ser Pro 
465                 470                 475                 480 


Leu Gly Ser Ser Asp Ala Leu Gln Ser Thr Val Pro Arg Ala Arg Asp 
                485                 490                 495     


Pro Pro Val Ala Thr Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly 
            500                 505                 510         


Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val Asn Gly His Lys 
        515                 520                 525             


Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu 
    530                 535                 540                 


Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro 
545                 550                 555                 560 


Thr Leu Val Thr Thr Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr 
                565                 570                 575     


Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu 
            580                 585                 590         


Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr 
        595                 600                 605             


Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg 
    610                 615                 620                 


Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly 
625                 630                 635                 640 


His Lys Leu Glu Tyr Asn Tyr Asn Ser His Asn Val Tyr Ile Met Ala 
                645                 650                 655     


Asp Lys Gln Lys Asn Gly Ile Lys Val Asn Phe Lys Ile Arg His Asn 
            660                 665                 670         


Ile Glu Asp Gly Ser Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr 
        675                 680                 685             


Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser 
    690                 695                 700                 


Thr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met 
705                 710                 715                 720 


Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp 
                725                 730                 735     


Glu Leu Tyr Lys 
            740 


<210>  27
<211>  745
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimera of CLEC14A, CD141 and GFP

<400>  27

Met Arg Pro Ala Phe Ala Leu Cys Leu Leu Trp Gln Ala Leu Trp Pro 
1               5                   10                  15      


Gly Pro Gly Gly Gly Glu His Pro Thr Ala Asp Arg Ala Gly Cys Ser 
            20                  25                  30          


Ala Ser Gly Ala Cys Tyr Ser Leu His His Ala Thr Met Lys Arg Gln 
        35                  40                  45              


Ala Ala Glu Glu Ala Cys Ile Leu Arg Gly Gly Ala Leu Ser Thr Val 
    50                  55                  60                  


Arg Ala Gly Ala Glu Leu Arg Ala Val Leu Ala Leu Leu Arg Ala Gly 
65                  70                  75                  80  


Pro Gly Pro Gly Gly Gly Ser Lys Asp Leu Leu Phe Trp Val Ala Leu 
                85                  90                  95      


Glu Arg Arg Arg Ser His Cys Thr Leu Glu Asn Glu Pro Leu Arg Gly 
            100                 105                 110         


Phe Ser Trp Leu Ser Ser Asp Pro Gly Gly Leu Glu Ser Asp Thr Leu 
        115                 120                 125             


Gln Trp Val Glu Glu Pro Gln Arg Ser Cys Thr Ala Arg Arg Cys Ala 
    130                 135                 140                 


Val Leu Gln Ala Thr Gly Gly Val Glu Pro Ala Gly Trp Lys Glu Met 
145                 150                 155                 160 


Arg Cys His Leu Arg Ala Asn Gly Tyr Leu Cys Lys Tyr His Phe Pro 
                165                 170                 175     


Ala Thr Cys Arg Pro Leu Ala Val Glu Pro Gly Ala Ala Ala Ala Ala 
            180                 185                 190         


Val Ser Ile Thr Tyr Gly Thr Pro Phe Ala Ala Arg Gly Ala Asp Phe 
        195                 200                 205             


Gln Ala Leu Pro Val Gly Ser Ser Ala Ala Val Ala Pro Leu Gly Leu 
    210                 215                 220                 


Gln Leu Met Cys Thr Ala Pro Pro Gly Ala Val Gln Gly His Trp Ala 
225                 230                 235                 240 


Arg Glu Ala Pro Gly Ala Cys Pro Gly Arg Tyr Leu Arg Ala Gly Lys 
                245                 250                 255     


Cys Ala Glu Leu Pro Asn Cys Leu Asp Asp Leu Gly Gly Phe Ala Cys 
            260                 265                 270         


Glu Cys Ala Thr Gly Phe Glu Leu Gly Lys Asp Gly Arg Ser Cys Val 
        275                 280                 285             


Thr Ser Gly Glu Gly Gln Pro Thr Leu Gly Gly Thr Gly Val Pro Thr 
    290                 295                 300                 


Arg Arg Pro Pro Ala Thr Ala Thr Ser Pro Val Pro Gln Arg Thr Trp 
305                 310                 315                 320 


Pro Ile Arg Val Asp Glu Lys Leu Gly Glu Thr Pro Leu Val Pro Glu 
                325                 330                 335     


Gln Asp Asn Ser Val Thr Ser Ile Pro Glu Ile Pro Arg Trp Gly Ser 
            340                 345                 350         


Gln Ser Thr Met Ser Thr Leu Gln Met Ser Leu Gln Ala Glu Ser Lys 
        355                 360                 365             


Ala Thr Ile Thr Pro Ser Gly Ser Val Ile Ser Lys Phe Asn Ser Thr 
    370                 375                 380                 


Thr Ser Ser Ala Thr Pro Gln Ala Phe Asp Ser Ser Ser Ala Val Val 
385                 390                 395                 400 


Phe Ile Phe Val Ser Thr Ala Val Val Val Leu Val Ile Leu Thr Met 
                405                 410                 415     


Thr Val Leu Gly Leu Val Lys Leu Cys Phe His Glu Ser Pro Ser Ser 
            420                 425                 430         


Gln Pro Arg Lys Glu Ser Met Gly Pro Pro Gly Leu Glu Ser Asp Pro 
        435                 440                 445             


Glu Pro Ala Ala Leu Gly Ser Ser Ser Ala His Cys Thr Asn Asn Gly 
    450                 455                 460                 


Val Lys Val Gly Asp Cys Asp Leu Arg Asp Arg Ala Glu Gly Ala Leu 
465                 470                 475                 480 


Leu Ala Glu Ser Pro Leu Gly Ser Ser Asp Ala Leu Gln Ser Thr Val 
                485                 490                 495     


Pro Arg Ala Arg Asp Pro Pro Val Ala Thr Met Val Ser Lys Gly Glu 
            500                 505                 510         


Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp 
        515                 520                 525             


Val Asn Gly His Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala 
    530                 535                 540                 


Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu 
545                 550                 555                 560 


Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu Thr Tyr Gly Val Gln 
                565                 570                 575     


Cys Phe Ser Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys 
            580                 585                 590         


Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys 
        595                 600                 605             


Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp 
    610                 615                 620                 


Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp 
625                 630                 635                 640 


Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Tyr Asn Ser His Asn 
                645                 650                 655     


Val Tyr Ile Met Ala Asp Lys Gln Lys Asn Gly Ile Lys Val Asn Phe 
            660                 665                 670         


Lys Ile Arg His Asn Ile Glu Asp Gly Ser Val Gln Leu Ala Asp His 
        675                 680                 685             


Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp 
    690                 695                 700                 


Asn His Tyr Leu Ser Thr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu 
705                 710                 715                 720 


Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile 
                725                 730                 735     


Thr Leu Gly Met Asp Glu Leu Tyr Lys 
            740                 745 


<210>  28
<211>  949
<212>  PRT
<213>  Unknown

<220>
<223>  MMRN2 protein sequence

<400>  28

Met Ile Leu Ser Leu Leu Phe Ser Leu Gly Gly Pro Leu Gly Trp Gly 
1               5                   10                  15      


Leu Leu Gly Ala Trp Ala Gln Ala Ser Ser Thr Ser Leu Ser Asp Leu 
            20                  25                  30          


Gln Ser Ser Arg Thr Pro Gly Val Trp Lys Ala Glu Ala Glu Asp Thr 
        35                  40                  45              


Gly Lys Asp Pro Val Gly Arg Asn Trp Cys Pro Tyr Pro Met Ser Lys 
    50                  55                  60                  


Leu Val Thr Leu Leu Ala Leu Cys Lys Thr Glu Lys Phe Leu Ile His 
65                  70                  75                  80  


Ser Gln Gln Pro Cys Pro Gln Gly Ala Pro Asp Cys Gln Lys Val Lys 
                85                  90                  95      


Val Met Tyr Arg Met Ala His Lys Pro Val Tyr Gln Val Lys Gln Lys 
            100                 105                 110         


Val Leu Thr Ser Leu Ala Trp Arg Cys Cys Pro Gly Tyr Thr Gly Pro 
        115                 120                 125             


Asn Cys Glu His His Asp Ser Met Ala Ile Pro Glu Pro Ala Asp Pro 
    130                 135                 140                 


Gly Asp Ser His Gln Glu Pro Gln Asp Gly Pro Val Ser Phe Lys Pro 
145                 150                 155                 160 


Gly His Leu Ala Ala Val Ile Asn Glu Val Glu Val Gln Gln Glu Gln 
                165                 170                 175     


Gln Glu His Leu Leu Gly Asp Leu Gln Asn Asp Val His Arg Val Ala 
            180                 185                 190         


Asp Ser Leu Pro Gly Leu Trp Lys Ala Leu Pro Gly Asn Leu Thr Ala 
        195                 200                 205             


Ala Val Met Glu Ala Asn Gln Thr Gly His Glu Phe Pro Asp Arg Ser 
    210                 215                 220                 


Leu Glu Gln Val Leu Leu Pro His Val Asp Thr Phe Leu Gln Val His 
225                 230                 235                 240 


Phe Ser Pro Ile Trp Arg Ser Phe Asn Gln Ser Leu His Ser Leu Thr 
                245                 250                 255     


Gln Ala Ile Arg Asn Leu Ser Leu Asp Val Glu Ala Asn Arg Gln Ala 
            260                 265                 270         


Ile Ser Arg Val Gln Asp Ser Ala Val Ala Arg Ala Asp Phe Gln Glu 
        275                 280                 285             


Leu Gly Ala Lys Phe Glu Ala Lys Val Gln Glu Asn Thr Gln Arg Val 
    290                 295                 300                 


Gly Gln Leu Arg Gln Asp Val Glu Asp Arg Leu His Ala Gln His Phe 
305                 310                 315                 320 


Thr Leu His Arg Ser Ile Ser Glu Leu Gln Ala Asp Val Asp Thr Lys 
                325                 330                 335     


Leu Lys Arg Leu His Lys Ala Gln Glu Ala Pro Gly Thr Asn Gly Ser 
            340                 345                 350         


Leu Val Leu Ala Thr Pro Gly Ala Gly Ala Arg Pro Glu Pro Asp Ser 
        355                 360                 365             


Leu Gln Ala Arg Leu Gly Gln Leu Gln Arg Asn Leu Ser Glu Leu His 
    370                 375                 380                 


Met Thr Thr Ala Arg Arg Glu Glu Glu Leu Gln Tyr Thr Leu Glu Asp 
385                 390                 395                 400 


Met Arg Ala Thr Leu Thr Arg His Val Asp Glu Ile Lys Glu Leu Tyr 
                405                 410                 415     


Ser Glu Ser Asp Glu Thr Phe Asp Gln Ile Ser Lys Val Glu Arg Gln 
            420                 425                 430         


Val Glu Glu Leu Gln Val Asn His Thr Ala Leu Arg Glu Leu Arg Val 
        435                 440                 445             


Ile Leu Met Glu Lys Ser Leu Ile Met Glu Glu Asn Lys Glu Glu Val 
    450                 455                 460                 


Glu Arg Gln Leu Leu Glu Leu Asn Leu Thr Leu Gln His Leu Gln Gly 
465                 470                 475                 480 


Gly His Ala Asp Leu Ile Lys Tyr Val Lys Asp Cys Asn Cys Gln Lys 
                485                 490                 495     


Leu Tyr Leu Asp Leu Asp Val Ile Arg Glu Gly Gln Arg Asp Ala Thr 
            500                 505                 510         


Arg Ala Leu Glu Glu Thr Gln Val Ser Leu Asp Glu Arg Arg Gln Leu 
        515                 520                 525             


Asp Gly Ser Ser Leu Gln Ala Leu Gln Asn Ala Val Asp Ala Val Ser 
    530                 535                 540                 


Leu Ala Val Asp Ala His Lys Ala Glu Gly Glu Arg Ala Arg Ala Ala 
545                 550                 555                 560 


Thr Ser Arg Leu Arg Ser Gln Val Gln Ala Leu Asp Asp Glu Val Gly 
                565                 570                 575     


Ala Leu Lys Ala Ala Ala Ala Glu Ala Arg His Glu Val Arg Gln Leu 
            580                 585                 590         


His Ser Ala Phe Ala Ala Leu Leu Glu Asp Ala Leu Arg His Glu Ala 
        595                 600                 605             


Val Leu Ala Ala Leu Phe Gly Glu Glu Val Leu Glu Glu Met Ser Glu 
    610                 615                 620                 


Gln Thr Pro Gly Pro Leu Pro Leu Ser Tyr Glu Gln Ile Arg Val Ala 
625                 630                 635                 640 


Leu Gln Asp Ala Ala Ser Gly Leu Gln Glu Gln Ala Leu Gly Trp Asp 
                645                 650                 655     


Glu Leu Ala Ala Arg Val Thr Ala Leu Glu Gln Ala Ser Glu Pro Pro 
            660                 665                 670         


Arg Pro Ala Glu His Leu Glu Pro Ser His Asp Ala Gly Arg Glu Glu 
        675                 680                 685             


Ala Ala Thr Thr Ala Leu Ala Gly Leu Ala Arg Glu Leu Gln Ser Leu 
    690                 695                 700                 


Ser Asn Asp Val Lys Asn Val Gly Arg Cys Cys Glu Ala Glu Ala Gly 
705                 710                 715                 720 


Ala Gly Ala Ala Ser Leu Asn Ala Ser Leu Asp Gly Leu His Asn Ala 
                725                 730                 735     


Leu Phe Ala Thr Gln Arg Ser Leu Glu Gln His Gln Arg Leu Phe His 
            740                 745                 750         


Ser Leu Phe Gly Asn Phe Gln Gly Leu Met Glu Ala Asn Val Ser Leu 
        755                 760                 765             


Asp Leu Gly Lys Leu Gln Thr Met Leu Ser Arg Lys Gly Lys Lys Gln 
    770                 775                 780                 


Gln Lys Asp Leu Glu Ala Pro Arg Lys Arg Asp Lys Lys Glu Ala Glu 
785                 790                 795                 800 


Pro Leu Val Asp Ile Arg Val Thr Gly Pro Val Pro Gly Ala Leu Gly 
                805                 810                 815     


Ala Ala Leu Trp Glu Ala Gly Ser Pro Val Ala Phe Tyr Ala Ser Phe 
            820                 825                 830         


Ser Glu Gly Thr Ala Ala Leu Gln Thr Val Lys Phe Asn Thr Thr Tyr 
        835                 840                 845             


Ile Asn Ile Gly Ser Ser Tyr Phe Pro Glu His Gly Tyr Phe Arg Ala 
    850                 855                 860                 


Pro Glu Arg Gly Val Tyr Leu Phe Ala Val Ser Val Glu Phe Gly Pro 
865                 870                 875                 880 


Gly Pro Gly Thr Gly Gln Leu Val Phe Gly Gly His His Arg Thr Pro 
                885                 890                 895     


Val Cys Thr Thr Gly Gln Gly Ser Gly Ser Thr Ala Thr Val Phe Ala 
            900                 905                 910         


Met Ala Glu Leu Gln Lys Gly Glu Arg Val Trp Phe Glu Leu Thr Gln 
        915                 920                 925             


Gly Ser Ile Thr Lys Arg Ser Leu Ser Gly Thr Ala Phe Gly Gly Phe 
    930                 935                 940                 


Leu Met Phe Lys Thr 
945                 


<210>  29
<211>  2850
<212>  DNA
<213>  Unknown

<220>
<223>  MMRN2 nucleotide

<400>  29
atgatcctga gcttgctgtt cagccttggg ggccccctgg gctgggggct gctgggggca       60

tgggcccagg cttccagtac tagcctctct gatctgcaga gctccaggac acctggggtc      120

tggaaggcag aggctgagga caccggcaag gaccccgttg gacgtaactg gtgcccctac      180

ccaatgtcca agctggtcac cttactagct ctttgcaaaa cagagaaatt cctcatccac      240

tcgcagcagc cgtgtccgca gggagctcca gactgccaga aagtcaaagt catgtaccgc      300

atggcccaca agccagtgta ccaggtcaag cagaaggtgc tgacctcttt ggcctggagg      360

tgctgccctg gctacacggg ccccaactgc gagcaccacg attccatggc aatccctgag      420

cctgcagatc ctggtgacag ccaccaggaa cctcaggatg gaccagtcag cttcaaacct      480

ggccaccttg ctgcagtgat caatgaggtt gaggtgcaac aggaacagca ggaacatctg      540

ctgggagatc tccagaatga tgtgcaccgg gtggcagaca gcctgccagg cctgtggaaa      600

gccctgcctg gtaacctcac agctgcagtg atggaagcaa atcaaacagg gcacgagttc      660

cctgatagat ccttggagca ggtgctgcta ccccacgtgg acaccttcct acaagtgcat      720

ttcagcccca tctggaggag ctttaaccaa agcctgcaca gccttaccca ggccataaga      780

aacctgtctc ttgacgtgga ggccaaccgc caggccatct ccagagtcca ggacagtgcc      840

gtggccaggg ctgacttcca ggagcttggt gccaaatttg aggccaaggt ccaggagaac      900

actcagagag tgggtcagct gcgacaggac gtggaggacc gcctgcacgc ccagcacttt      960

accctgcacc gctcgatctc agagctccaa gccgatgtgg acaccaaatt gaagaggctg     1020

cacaaggctc aggaggcccc agggaccaat ggcagtctgg tgttggcaac gcctggggct     1080

ggggcaaggc ctgagccgga cagcctgcag gccaggctgg gccagctgca gaggaacctc     1140

tcagagctgc acatgaccac ggcccgcagg gaggaggagt tgcagtacac cctggaggac     1200

atgagggcca ccctgacccg gcacgtggat gagatcaagg aactgtactc cgaatcggac     1260

gagactttcg atcagattag caaggtggag cggcaggtgg aggagctgca ggtgaaccac     1320

acggcgctcc gtgagctgcg cgtgatcctg atggagaagt ctctgatcat ggaggagaac     1380

aaggaggagg tggagcggca gctcctggag ctcaacctca cgctgcagca cctgcagggt     1440

ggccatgccg acctcatcaa gtacgtgaag gactgcaatt gccagaagct ctatttagac     1500

ctggacgtca tccgggaggg ccagagggac gccacgcgtg ccctggagga gacccaggtg     1560

agcctggacg agcggcggca gctggacggc tcctccctgc aggccctgca gaacgccgtg     1620

gacgccgtgt cgctggccgt ggacgcgcac aaagcggagg gcgagcgggc gcgggcggcc     1680

acgtcgcggc tccggagcca agtgcaggcg ctggatgacg aggtgggcgc gctgaaggcg     1740

gccgcggccg aggcccgcca cgaggtgcgc cagctgcaca gcgccttcgc cgccctgctg     1800

gaggacgcgc tgcggcacga ggcggtgctg gccgcgctct tcggggagga ggtgctggag     1860

gagatgtctg agcagacgcc gggaccgctg cccctgagct acgagcagat ccgcgtggcc     1920

ctgcaggacg ccgctagcgg gctgcaggag caggcgctcg gctgggacga gctggccgcc     1980

cgagtgacgg ccctggagca ggcctcggag cccccgcggc cggcagagca cctggagccc     2040

agccacgacg cgggccgcga ggaggccgcc accaccgccc tggccgggct ggcgcgggag     2100

ctccagagcc tgagcaacga cgtcaagaat gtcgggcggt gctgcgaggc tgaggccggg     2160

gccggggccg cctccctcaa cgcctccctt gacggcctcc acaacgcact cttcgccact     2220

cagcgcagct tggagcagca ccagcggctc ttccacagcc tctttgggaa cttccaaggg     2280

ctcatggaag ccaacgtcag cctggacctg gggaagctgc agaccatgct gagcaggaaa     2340

gggaagaagc agcagaaaga cctggaagct ccccggaaga gggacaagaa ggaagcggag     2400

cctttggtgg acatacgggt cacagggcct gtgccaggtg ccttgggcgc ggcgctctgg     2460

gaggcaggat cccctgtggc cttctatgcc agcttttcag aagggacggc tgccctgcag     2520

acagtgaagt tcaacaccac atacatcaac attggcagca gctacttccc tgaacatggc     2580

tacttccgag cccctgagcg tggtgtctac ctgtttgcag tgagcgttga atttggccca     2640

gggccaggca ccgggcagct ggtgtttgga ggtcaccatc ggactccagt ctgtaccact     2700

gggcagggga gtggaagcac agcaacggtc tttgccatgg ctgagctgca gaagggtgag     2760

cgagtatggt ttgagttaac ccagggatca ataacaaaga gaagcctgtc gggcactgca     2820

tttgggggct tcctgatgtt taagacctga                                      2850


<210>  30
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  siRNA duplex D1

<400>  30
gaacaagaca attcagtaa                                                    19


<210>  31
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  siRNA duplex D2

<400>  31
caatcagggt cgacgagaa                                                    19


<210>  32
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 heavy chain variant 1 of CRT1

<400>  32

Ser Ser Tyr Trp Ile Glu 
1               5       


<210>  33
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 of heavy chain variant 1 of CRT1

<400>  33

Trp Ile Gly Glu Ile Leu Pro Gly Ser Gly Ser Thr Asn 
1               5                   10              


<210>  34
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of heavy chain variant 1 of CRT1

<400>  34

Ala Arg Gly Gly Asp Tyr Asp Glu Glu Tyr Tyr Val Met Asp 
1               5                   10                  


<210>  35
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR 1 of light chain variant 1 of CRT1

<400>  35

Ser Tyr Met Tyr Trp Tyr 
1               5       


<210>  36
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 of light chain variant 1 of CRT1

<400>  36

Leu Leu Ile Tyr Asp Thr Ser Asn Leu Ala 
1               5                   10  


<210>  37
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of light chain variant 1 of CRT1

<400>  37

Gln Gln Trp Ser Ser Tyr Pro Leu 
1               5               


<210>  38
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDR1 of heavy chain variant 1 of CRT1

<400>  38
agtagctact ggatagag                                                     18


<210>  39
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDR2 of heavy chain variant 1 of CRT1

<400>  39
tggattggag agattttacc tggaagtggt agtactaat                              39


<210>  40
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDR3 heavy chain variant 1 of CRT1

<400>  40
gcaagagggg gggattacga cgaagaatac tatgtcatgg ac                          42


<210>  41
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDR1 of light chain variant 1 of CRT1

<400>  41
agttacatgt actggtac                                                     18


<210>  42
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDR2 of light chain variant 1 of CRT1

<400>  42
ctcctgattt atgacacatc caacctggct                                        30


<210>  43
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDR3 of light chain variant 1 of CRT1

<400>  43
cagcagtgga gtagttaccc gctc                                              24


<210>  44
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 of heavy chain variant 2 of CRT1

<400>  44

Gly Tyr Thr Phe Ser Ser Tyr Trp 
1               5               


<210>  45
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 of heavy chain variant 2 of CRT1

<400>  45

Ile Leu Pro Gly Ser Gly Ser Thr 
1               5               


<210>  46
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of heavy chain variant 2 of CRT1

<400>  46

Ala Arg Gly Gly Asp Tyr Asp Glu Glu Tyr Tyr Val Met Asp Tyr 
1               5                   10                  15  


<210>  47
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 of light chain variant 2 of CRT1

<400>  47

Ser Ser Val Ser Tyr 
1               5   


<210>  48
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence for OX40 costimulatory domain

<400>  48
agggaccaga ggctgccccc cgatgcccac aagccccctg ggggaggcag tttccggacc       60

cccatccaag aggagcaggc cgacgcccac tccaccctgg ccaagatc                   108


<210>  49
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 light chain variant 2 of CRT1

<400>  49

Gln Gln Trp Ser Ser Tyr Pro Leu Thr 
1               5                   


<210>  50
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDR1 heavy chain variant 2 of CRT1

<400>  50
ggctacacat tcagtagcta ctgg                                              24


<210>  51
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDR2 heavy chain variant 2 of CRT1

<400>  51
attttacctg gaagtggtag tact                                              24


<210>  52
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDR3 of heavy chain variant 2 of CRT1

<400>  52
gcaagagggg gggattacga cgaagaatac tatgtcatgg actac                       45


<210>  53
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDR1 of light chain variant 2 of CRT1

<400>  53
tcaagtgtaa gttac                                                        15


<210>  54
<211>  204
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence for CD28 costimulatory domain

<400>  54
ttttgggtgc tggtggtggt tggtggagtc ctggcttgct atagcttgct agtaacagtg       60

gcctttatta ttttctgggt gaggagtaag aggagcaggc tcctgcacag tgactacatg      120

aacatgactc cccgccgccc cgggcccacc cgcaagcatt accagcccta tgccccacca      180

cgcgacttcg cagcctatcg ctcc                                             204


<210>  55
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDR3 of light chain variant 2 for CRT1

<400>  55
cagcagtgga gtagttaccc gctcacg                                           27


<210>  56
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CRT1 heavy chain protein

<400>  56

Met Ala Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Met Lys Pro 
1               5                   10                  15      


Gly Ala Ser Val Lys Ile Ser Cys Lys Ala Thr Gly Tyr Thr Phe Ser 
            20                  25                  30          


Ser Tyr Trp Ile Glu Trp Val Lys Gln Arg Pro Gly His Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Glu Ile Leu Pro Gly Ser Gly Ser Thr Asn Tyr Asn Glu 
    50                  55                  60                  


Lys Phe Lys Gly Lys Ala Thr Phe Thr Ala Asp Thr Ser Ser Asn Thr 
65                  70                  75                  80  


Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Gly Gly Asp Tyr Asp Glu Glu Tyr Tyr Val Met Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Ser Val Thr Val 
        115                 120         


<210>  57
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CRT1 light chain protein

<400>  57

Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Arg Leu Leu Ile Tyr 
        35                  40                  45              


Asp Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Tyr Pro Leu Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg 
            100                 105         


<210>  58
<211>  249
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CRT1 scFv protein

<400>  58

Met Ala Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Met Lys Pro 
1               5                   10                  15      


Gly Ala Ser Val Lys Ile Ser Cys Lys Ala Thr Gly Tyr Thr Phe Ser 
            20                  25                  30          


Ser Tyr Trp Ile Glu Trp Val Lys Gln Arg Pro Gly His Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Glu Ile Leu Pro Gly Ser Gly Ser Thr Asn Tyr Asn Glu 
    50                  55                  60                  


Lys Phe Lys Gly Lys Ala Thr Phe Thr Ala Asp Thr Ser Ser Asn Thr 
65                  70                  75                  80  


Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Gly Gly Asp Tyr Asp Glu Glu Tyr Tyr Val Met Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ile Val Leu Thr 
    130                 135                 140                 


Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly Glu Lys Val Thr Met 
145                 150                 155                 160 


Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Tyr Trp Tyr Gln Gln 
                165                 170                 175     


Lys Pro Gly Ser Ser Pro Arg Leu Leu Ile Tyr Asp Thr Ser Asn Leu 
            180                 185                 190         


Ala Ser Gly Val Pro Val Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser 
        195                 200                 205             


Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu Asp Ala Ala Thr Tyr 
    210                 215                 220                 


Tyr Cys Gln Gln Trp Ser Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr 
225                 230                 235                 240 


Lys Leu Glu Leu Lys Arg Ala Ala Ala 
                245                 


<210>  59
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CRT1 heavy chain nucleotide

<400>  59
atggccgagg ttcagcttca gcagtctgga gctgagctga tgaagcctgg ggcctcagtg       60

aagatatcct gcaaggctac tggctacaca ttcagtagct actggataga gtgggtaaag      120

cagaggcctg gacatggcct tgagtggatt ggagagattt tacctggaag tggtagtact      180

aattacaatg agaagttcaa gggcaaggcc acattcactg cagatacatc ctccaacaca      240

gcctacatgc aactcagcag cctgacatct gaggactctg ccgtctatta ctgtgcaaga      300

gggggggatt acgacgaaga atactatgtc atggactact ggggtcaagg aacctcagtc      360

actgtc                                                                 366


<210>  60
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CRT1 light chain nucleotide

<400>  60
caaattgttc tcacccagtc tccagcaatc atgtctgcat ctccagggga gaaggtcacc       60

atgacctgca gtgccagctc aagtgtaagt tacatgtact ggtaccagca gaagccagga      120

tcctccccca gactcctgat ttatgacaca tccaacctgg cttctggagt ccctgttcgc      180

ttcagtggca gtgggtctgg gacctcttac tctctcacaa tcagccgaat ggaggctgaa      240

gatgctgcca cttattactg ccagcagtgg agtagttacc cgctcacgtt cggtgctggg      300

accaagctgg agctgaaacg t                                                321


<210>  61
<211>  747
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CRT1 scFv nucleotide

<400>  61
atggccgagg ttcagcttca gcagtctgga gctgagctga tgaagcctgg ggcctcagtg       60

aagatatcct gcaaggctac tggctacaca ttcagtagct actggataga gtgggtaaag      120

cagaggcctg gacatggcct tgagtggatt ggagagattt tacctggaag tggtagtact      180

aattacaatg agaagttcaa gggcaaggcc acattcactg cagatacatc ctccaacaca      240

gcctacatgc aactcagcag cctgacatct gaggactctg ccgtctatta ctgtgcaaga      300

gggggggatt acgacgaaga atactatgtc atggactact ggggtcaagg aacctcagtc      360

actgtctcct caggtggagg cggttcaggc ggaggtggct ctggcggtgg cggatcgcaa      420

attgttctca cccagtctcc agcaatcatg tctgcatctc caggggagaa ggtcaccatg      480

acctgcagtg ccagctcaag tgtaagttac atgtactggt accagcagaa gccaggatcc      540

tcccccagac tcctgattta tgacacatcc aacctggctt ctggagtccc tgttcgcttc      600

agtggcagtg ggtctgggac ctcttactct ctcacaatca gccgaatgga ggctgaagat      660

gctgccactt attactgcca gcagtggagt agttacccgc tcacgttcgg tgctgggacc      720

aagctggagc tgaaacgtgc ggccgca                                          747


<210>  62
<211>  493
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CRT1 CAR1 protein

<400>  62

Met Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu Ala 
1               5                   10                  15      


Leu Leu Phe Pro Ser Met Ala Ser Met Ala Glu Val Gln Leu Gln Gln 
            20                  25                  30          


Ser Gly Ala Glu Leu Met Lys Pro Gly Ala Ser Val Lys Ile Ser Cys 
        35                  40                  45              


Lys Ala Thr Gly Tyr Thr Phe Ser Ser Tyr Trp Ile Glu Trp Val Lys 
    50                  55                  60                  


Gln Arg Pro Gly His Gly Leu Glu Trp Ile Gly Glu Ile Leu Pro Gly 
65                  70                  75                  80  


Ser Gly Ser Thr Asn Tyr Asn Glu Lys Phe Lys Gly Lys Ala Thr Phe 
                85                  90                  95      


Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr Met Gln Leu Ser Ser Leu 
            100                 105                 110         


Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Gly Gly Asp Tyr 
        115                 120                 125             


Asp Glu Glu Tyr Tyr Val Met Asp Tyr Trp Gly Gln Gly Thr Ser Val 
    130                 135                 140                 


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala 
                165                 170                 175     


Ser Pro Gly Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val 
            180                 185                 190         


Ser Tyr Met Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Arg Leu 
        195                 200                 205             


Leu Ile Tyr Asp Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe 
    210                 215                 220                 


Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met 
225                 230                 235                 240 


Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Tyr 
                245                 250                 255     


Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Ala Ala 
            260                 265                 270         


Ala Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser 
        275                 280                 285             


Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro 
    290                 295                 300                 


Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly 
305                 310                 315                 320 


Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile 
                325                 330                 335     


Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met 
            340                 345                 350         


Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro 
        355                 360                 365             


Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe 
    370                 375                 380                 


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu 
385                 390                 395                 400 


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
                405                 410                 415     


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Gln Arg Arg 
            420                 425                 430         


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
        435                 440                 445             


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
    450                 455                 460                 


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
465                 470                 475                 480 


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490             


<210>  63
<211>  1502
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CRT1 CAR1 nucleotide

<400>  63
atgggcgtgc tgctgaccca gaggaccctg ctgagcctgg tgctggccct gctgtttcca       60

tctatggcat cgatggccga ggttcagctt cagcagtctg gagctgagct gatgaagcct      120

ggggcctcag tgaagatatc ctgcaaggct actggctaca cattcagtag ctactggata      180

gagtgggtaa agcagaggcc tggacatggc cttgagtgga ttggagagat tttacctgga      240

agtggtagta ctaattacaa tgagaagttc aagggcaagg ccacattcac tgcagataca      300

tcctccaaca cagcctacat gcaactcagc agcctgacat ctgaggactc tgccgtctat      360

tactgtgcaa gaggggggga ttacgacgaa gaatactatg tcatggacta ctggggtcaa      420

ggaacctcag tcactgtctc ctcaggtgga ggcggttcag gcggaggtgg ctctggcggt      480

ggcggatcgc aaattgttct cacccagtct ccagcaatca tgtctgcatc tccaggggag      540

aaggtcacca tgacctgcag tgccagctca agtgtaagtt acatgtactg gtaccagcag      600

aagccaggat cctcccccag actcctgatt tatgacacat ccaacctggc ttctggagtc      660

cctgttcgct tcagtggcag tgggtctggg acctcttact ctctcacaat cagccgaatg      720

gaggctgaag atgctgccac ttattactgc cagcagtgga gtagttaccc gctcacgttc      780

ggtgctggga ccaagctgga gctgaaacgt gcggccgcaa ttgaagttat gtatcctcct      840

ccttacctag acaatgagaa gagcaatgga accattatcc atgtgaaagg gaaacacctt      900

tgtccaagtc ccctatttcc cggaccttct aagccctttt gggtgctggt ggtggttggt      960

ggagtcctgg cttgctatag cttgctagta acagtggcct ttattatttt ctgggtgagg     1020

agtaagagga gcaggctcct gcacagtgac tacatgaaca tgactccccg ccgccccggg     1080

cccacccgca agcattacca gccctatgcc ccaccacgcg acttcgcagc ctatcgctcc     1140

agagtgaagt tcagcaggag cgcagacgcc cccgcgtacc agcagggcca gaaccagctc     1200

tataacgagc tcaatctagg acgaagagag gagtacgatg ttttggacaa gagacgtggc     1260

cgggaccctg agatgggggg aaagccgcag agaaggaaga accctcagga aggcctgtac     1320

aatgaactgc agaaagataa gatggcggag gcctacagtg agattgggat gaaaggcgag     1380

cgccggaggg gcaaggggca cgatggcctt taccagggtc tcagtacagc caccaaggac     1440

acctacgacg cccttcacat gcaggccctg ccccctcgct aataaaagct taacacgagc     1500

ca                                                                    1502


<210>  64
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 of heavy chain variant 1 of CRT3

<400>  64

Thr Ser Tyr Trp Met His 
1               5       


<210>  65
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 of heavy chain variant 1 of CRT3

<400>  65

Trp Ile Gly Ala Ile Tyr Pro Gly Asn Ser Asp Thr Ser 
1               5                   10              


<210>  66
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of heavy chain variant 1 of CRT3

<400>  66

Thr His Tyr Tyr Gly Ser Asp Tyr Ala Met Asp 
1               5                   10      


<210>  67
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 of light chain variant 1 of CRT3

<400>  67

Ser Ser Ser Tyr Leu His Trp Tyr 
1               5               


<210>  68
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 of light chain variant 1 of CRT3

<400>  68

Leu Trp Ile Tyr Ser Thr Ser Asn Leu Ala 
1               5                   10  


<210>  69
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of light chain variant 1 of CRT3

<400>  69

His Gln Tyr His Arg Ser Pro Arg 
1               5               


<210>  70
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDR1 of heavy chain variant 1 of CRT3

<400>  70
accagctact ggatgcac                                                     18


<210>  71
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDR2 of heavy chain variant 1 of CRT3

<400>  71
tggattggcg ctatttatcc tggaaatagt gatactagc                              39


<210>  72
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDR3 of heavy chain variant 1 of CRT3

<400>  72
acacattact acggtagtga ctatgctatg gac                                    33


<210>  73
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDR1 of light chain variant 1 of CRT3

<400>  73
agttccagtt acttgcactg gtac                                              24


<210>  74
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDR2 of light chain variant 1 of CRT3

<400>  74
ctctggattt atagcacatc caacctggct                                        30


<210>  75
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDR3 of light chain variant 1 of CRT3

<400>  75
ccaccagtat catcgttccc cacgg                                             25


<210>  76
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 of heavy chain variant 2 of CRT3

<400>  76

Gly Tyr Thr Phe Thr Ser Tyr Trp 
1               5               


<210>  77
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 of heavy chain variant 2 of CRT3

<400>  77

Ile Tyr Pro Gly Asn Ser Asp Thr 
1               5               


<210>  78
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of heavy chain variant 2 of CRT3

<400>  78

Thr His Tyr Tyr Gly Ser Asp Tyr Ala Met Asp Tyr 
1               5                   10          


<210>  79
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 of light chain variant 2 of CRT3

<400>  79

Ser Ser Val Ser Ser Ser Tyr 
1               5           


<210>  80
<211>  126
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence for 41BB costimulatory domain

<400>  80
aaacggggca gaaagaaact cctgtatata ttcaaacaac catttatgag accagtacaa       60

actactcaag aggaagatgg ctgtagctgc cgatttccag aagaagaaga aggaggatgt      120

gaactg                                                                 126


<210>  81
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of light chain variant 2 of CRT3

<400>  81

His Gln Tyr His Arg Ser Pro Arg Thr 
1               5                   


<210>  82
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDR1 of heavy chain variant 2 of CRT3

<400>  82
ggctacacct ttaccagcta ctgg                                              24


<210>  83
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDR2 of heavy chain variant 2 of CRT3

<400>  83
atttatcctg gaaatagtga tact                                              24


<210>  84
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDR3 of heavy chain variant 2 of CRT3

<400>  84
acacattact acggtagtga ctatgctatg gactac                                 36


<210>  85
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDR1 of light chain variant 2 of CRT3

<400>  85
tcaagtgtaa gttccagtta c                                                 21


<210>  86
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OX40 costimulatory domain

<400>  86

Arg Asp Gln Arg Leu Pro Pro Asp Ala His Lys Pro Pro Gly Gly Gly 
1               5                   10                  15      


Ser Phe Arg Thr Pro Ile Gln Glu Glu Gln Ala Asp Ala His Ser Thr 
            20                  25                  30          


Leu Ala Lys Ile 
        35      


<210>  87
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDR3 of light chain variant 2 of CRT3

<400>  87
caccagtatc atcgttcccc acggacg                                           27


<210>  88
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CRT3 heavy chain variant 1

<400>  88

Met Ala Glu Val Gln Leu Gln Gln Ser Gly Thr Val Leu Ala Arg Pro 
1               5                   10                  15      


Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 
            20                  25                  30          


Ser Tyr Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Ala Ile Tyr Pro Gly Asn Ser Asp Thr Ser Tyr Asn Gln 
    50                  55                  60                  


Lys Phe Lys Gly Lys Ala Lys Leu Thr Ala Val Thr Ser Thr Ser Thr 
65                  70                  75                  80  


Ala Tyr Met Glu Leu Ser Ser Leu Thr Asn Glu Asp Ser Ala Val Phe 
                85                  90                  95      


Tyr Cys Thr His Tyr Tyr Gly Ser Asp Tyr Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Ser Val Thr Ile Ser Ser Gly 
        115                 120         


<210>  89
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CRT3 light chain variant 1

<400>  89

Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Thr Met Thr Cys Thr Ala Ser Ser Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Leu Trp 
        35                  40                  45              


Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu 
65                  70                  75                  80  


Ala Glu Asp Ala Ala Thr Tyr Tyr Cys His Gln Tyr His Arg Ser Pro 
                85                  90                  95      


Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala Ala 
            100                 105                 110     


<210>  90
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CRT3 heavy chain variant 2

<400>  90

Met Ala Glu Val Gln Leu Gln Gln Ser Gly Thr Val Leu Ala Arg Pro 
1               5                   10                  15      


Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 
            20                  25                  30          


Ser Tyr Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Ala Ile Tyr Pro Gly Asn Ser Asp Thr Ser Tyr Asn Gln 
    50                  55                  60                  


Lys Phe Lys Gly Lys Ala Lys Leu Thr Ala Val Thr Ser Thr Ser Thr 
65                  70                  75                  80  


Ala Tyr Met Glu Leu Ser Ser Leu Thr Asn Glu Asp Ser Ala Val Phe 
                85                  90                  95      


Tyr Cys Thr His Tyr Tyr Gly Ser Asp Tyr Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Ser Val Thr Val 
        115                 


<210>  91
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CRT3 light chain variant 2

<400>  91

Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Thr Met Thr Cys Thr Ala Ser Ser Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Leu Trp 
        35                  40                  45              


Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu 
65                  70                  75                  80  


Ala Glu Asp Ala Ala Thr Tyr Tyr Cys His Gln Tyr His Arg Ser Pro 
                85                  90                  95      


Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala Ala Ala 
            100                 105                 110         


<210>  92
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CRT3 heavy chain variant 1 nucleotide sequence

<400>  92
atggccgagg tccagctgca gcagtctggg actgtgctgg caaggcctgg ggcttcagtg       60

aagatgtcct gcaaggcttc tggctacacc tttaccagct actggatgca ctgggtaaaa      120

cagaggcctg gacagggtct ggaatggatt ggcgctattt atcctggaaa tagtgatact      180

agctacaacc agaagttcaa gggcaaggcc aaactgactg cagtcacatc caccagcact      240

gcctacatgg agctcagcag cctgacaaat gaggactctg cggtctttta ctgtacacat      300

tactacggta gtgactatgc tatggactac tggggtcaag gaacctcagt cactgtctcc      360

tca                                                                    363


<210>  93
<211>  335
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CRT3 light chain variant 1 nucleotide sequence

<400>  93
caaattgttc tcacccagtc tccagcaatc atgtctgcat ctctagggga acgggtcacc       60

atgacctgca ctgccagctc aagtgtaagt tccagttact tgcactggta ccagcagaag      120

ccaggatcct cccccaaact ctggatttat agcacatcca acctggcttc tggagtccca      180

gctcgcttca gtggcagtgg gtctgggacc tcttactctc tcacaatcag cagcatggag      240

gctgaagatg ctgccactta ttactgccac cagtatcatc gttccccacg gacgttcggt      300

ggaggcacca agctggaaat caaacgtgcg gccgc                                 335


<210>  94
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CRT3 heavy chain variant 2 nucleotide sequence

<400>  94
atggccgagg tccagctgca gcagtctggg actgtgctgg caaggcctgg ggcttcagtg       60

aagatgtcct gcaaggcttc tggctacacc tttaccagct actggatgca ctgggtaaaa      120

cagaggcctg gacagggtct ggaatggatt ggcgctattt atcctggaaa tagtgatact      180

agctacaacc agaagttcaa gggcaaggcc aaactgactg cagtcacatc caccagcact      240

gcctacatgg agctcagcag cctgacaaat gaggactctg cggtctttta ctgtacacat      300

tactacggta gtgactatgc tatggactac tggggtcaag gaacctcagt cactgtc         357


<210>  95
<211>  327
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CRT3 light chain variant 2 nucleotide sequence

<400>  95
caaattgttc tcacccagtc tccagcaatc atgtctgcat ctctagggga acgggtcacc       60

atgacctgca ctgccagctc aagtgtaagt tccagttact tgcactggta ccagcagaag      120

ccaggatcct cccccaaact ctggatttat agcacatcca acctggcttc tggagtccca      180

gctcgcttca gtggcagtgg gtctgggacc tcttactctc tcacaatcag cagcatggag      240

gctgaagatg ctgccactta ttactgccac cagtatcatc gttccccacg gacgttcggt      300

ggaggcacca agctggaaat caaacgt                                          327


<210>  96
<211>  248
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CRT3 scFV

<400>  96

Met Ala Glu Val Gln Leu Gln Gln Ser Gly Thr Val Leu Ala Arg Pro 
1               5                   10                  15      


Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 
            20                  25                  30          


Ser Tyr Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Ala Ile Tyr Pro Gly Asn Ser Asp Thr Ser Tyr Asn Gln 
    50                  55                  60                  


Lys Phe Lys Gly Lys Ala Lys Leu Thr Ala Val Thr Ser Thr Ser Thr 
65                  70                  75                  80  


Ala Tyr Met Glu Leu Ser Ser Leu Thr Asn Glu Asp Ser Ala Val Phe 
                85                  90                  95      


Tyr Cys Thr His Tyr Tyr Gly Ser Asp Tyr Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gln Ile Val Leu Thr Gln Ser Pro 
    130                 135                 140                 


Ala Ile Met Ser Ala Ser Leu Gly Glu Arg Val Thr Met Thr Cys Thr 
145                 150                 155                 160 


Ala Ser Ser Ser Val Ser Ser Ser Tyr Leu His Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Ser Ser Pro Lys Leu Trp Ile Tyr Ser Thr Ser Asn Leu Ala 
            180                 185                 190         


Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr 
        195                 200                 205             


Ser Leu Thr Ile Ser Ser Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys His Gln Tyr His Arg Ser Pro Arg Thr Phe Gly Gly Gly Thr Lys 
225                 230                 235                 240 


Leu Glu Ile Lys Arg Ala Ala Ala 
                245             


<210>  97
<211>  744
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CRT3 scFV nucleotide sequence

<400>  97
atggccgagg tccagctgca gcagtctggg actgtgctgg caaggcctgg ggcttcagtg       60

aagatgtcct gcaaggcttc tggctacacc tttaccagct actggatgca ctgggtaaaa      120

cagaggcctg gacagggtct ggaatggatt ggcgctattt atcctggaaa tagtgatact      180

agctacaacc agaagttcaa gggcaaggcc aaactgactg cagtcacatc caccagcact      240

gcctacatgg agctcagcag cctgacaaat gaggactctg cggtctttta ctgtacacat      300

tactacggta gtgactatgc tatggactac tggggtcaag gaacctcagt cactgtctcc      360

tcaggtggag gcggttcagg cggaggtggc tctggcggtg gcggatcgca aattgttctc      420

acccagtctc cagcaatcat gtctgcatct ctaggggaac gggtcaccat gacctgcact      480

gccagctcaa gtgtaagttc cagttacttg cactggtacc agcagaagcc aggatcctcc      540

cccaaactct ggatttatag cacatccaac ctggcttctg gagtcccagc tcgcttcagt      600

ggcagtgggt ctgggacctc ttactctctc acaatcagca gcatggaggc tgaagatgct      660

gccacttatt actgccacca gtatcatcgt tccccacgga cgttcggtgg aggcaccaag      720

ctggaaatca aacgtgcggc cgca                                             744


<210>  98
<211>  492
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CRT3 CAR3

<400>  98

Met Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu Ala 
1               5                   10                  15      


Leu Leu Phe Pro Ser Met Ala Ser Met Ala Glu Val Gln Leu Gln Gln 
            20                  25                  30          


Ser Gly Thr Val Leu Ala Arg Pro Gly Ala Ser Val Lys Met Ser Cys 
        35                  40                  45              


Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Trp Met His Trp Val Lys 
    50                  55                  60                  


Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly Ala Ile Tyr Pro Gly 
65                  70                  75                  80  


Asn Ser Asp Thr Ser Tyr Asn Gln Lys Phe Lys Gly Lys Ala Lys Leu 
                85                  90                  95      


Thr Ala Val Thr Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu 
            100                 105                 110         


Thr Asn Glu Asp Ser Ala Val Phe Tyr Cys Thr His Tyr Tyr Gly Ser 
        115                 120                 125             


Asp Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Leu Gly 
                165                 170                 175     


Glu Arg Val Thr Met Thr Cys Thr Ala Ser Ser Ser Val Ser Ser Ser 
            180                 185                 190         


Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Leu Trp 
        195                 200                 205             


Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser 
    210                 215                 220                 


Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu 
225                 230                 235                 240 


Ala Glu Asp Ala Ala Thr Tyr Tyr Cys His Gln Tyr His Arg Ser Pro 
                245                 250                 255     


Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala Ala Ala 
            260                 265                 270         


Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn 
        275                 280                 285             


Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu 
    290                 295                 300                 


Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly 
305                 310                 315                 320 


Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe 
                325                 330                 335     


Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn 
            340                 345                 350         


Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr 
        355                 360                 365             


Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser 
    370                 375                 380                 


Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr 
385                 390                 395                 400 


Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys 
                405                 410                 415     


Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Gln Arg Arg Lys 
            420                 425                 430         


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
        435                 440                 445             


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
    450                 455                 460                 


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
465                 470                 475                 480 


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490         


<210>  99
<211>  1499
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CRT3 CAR3 nucleotide sequence

<400>  99
atgggcgtgc tgctgaccca gaggaccctg ctgagcctgg tgctggccct gctgtttcca       60

tctatggcat cgatggccga ggtccagctg cagcagtctg ggactgtgct ggcaaggcct      120

ggggcttcag tgaagatgtc ctgcaaggct tctggctaca cctttaccag ctactggatg      180

cactgggtaa aacagaggcc tggacagggt ctggaatgga ttggcgctat ttatcctgga      240

aatagtgata ctagctacaa ccagaagttc aagggcaagg ccaaactgac tgcagtcaca      300

tccaccagca ctgcctacat ggagctcagc agcctgacaa atgaggactc tgcggtcttt      360

tactgtacac attactacgg tagtgactat gctatggact actggggtca aggaacctca      420

gtcactgtct cctcaggtgg aggcggttca ggcggaggtg gctctggcgg tggcggatcg      480

caaattgttc tcacccagtc tccagcaatc atgtctgcat ctctagggga acgggtcacc      540

atgacctgca ctgccagctc aagtgtaagt tccagttact tgcactggta ccagcagaag      600

ccaggatcct cccccaaact ctggatttat agcacatcca acctggcttc tggagtccca      660

gctcgcttca gtggcagtgg gtctgggacc tcttactctc tcacaatcag cagcatggag      720

gctgaagatg ctgccactta ttactgccac cagtatcatc gttccccacg gacgttcggt      780

ggaggcacca agctggaaat caaacgtgcg gccgcaattg aagttatgta tcctcctcct      840

tacctagaca atgagaagag caatggaacc attatccatg tgaaagggaa acacctttgt      900

ccaagtcccc tatttcccgg accttctaag cccttttggg tgctggtggt ggttggtgga      960

gtcctggctt gctatagctt gctagtaaca gtggccttta ttattttctg ggtgaggagt     1020

aagaggagca ggctcctgca cagtgactac atgaacatga ctccccgccg ccccgggccc     1080

acccgcaagc attaccagcc ctatgcccca ccacgcgact tcgcagccta tcgctccaga     1140

gtgaagttca gcaggagcgc agacgccccc gcgtaccagc agggccagaa ccagctctat     1200

aacgagctca atctaggacg aagagaggag tacgatgttt tggacaagag acgtggccgg     1260

gaccctgaga tggggggaaa gccgcagaga aggaagaacc ctcaggaagg cctgtacaat     1320

gaactgcaga aagataagat ggcggaggcc tacagtgaga ttgggatgaa aggcgagcgc     1380

cggaggggca aggggcacga tggcctttac cagggtctca gtacagccac caaggacacc     1440

tacgacgccc ttcacatgca ggccctgccc cctcgctaat aaaagcttaa cacgagcca      1499


<210>  100
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 heavy chain variant 1 of CRT4

<400>  100

Ala Arg Gly Gly Asp Tyr Asp Glu Glu Tyr Tyr Leu Met Asp 
1               5                   10                  


<210>  101
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDR3 heavy chain variant 1 of CRT4

<400>  101
gcgagagggg gggattacga cgaagaatac tatctcatgg ac                          42


<210>  102
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of heavy chain variant 2 of CRT4

<400>  102

Ala Arg Gly Gly Asp Tyr Asp Glu Glu Tyr Tyr Leu Met Asp Tyr 
1               5                   10                  15  


<210>  103
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDR3 of heavy chain variant 2 of CRT4

<400>  103
gcgagagggg gggattacga cgaagaatac tatctcatta c                           41


<210>  104
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CRT4 variant 1 heavy chain

<400>  104

Met Ala Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Met Lys Pro 
1               5                   10                  15      


Gly Ala Ser Val Lys Ile Ser Cys Lys Ala Thr Gly Tyr Thr Phe Ser 
            20                  25                  30          


Ser Tyr Trp Ile Glu Trp Val Asn Arg Arg Pro Gly His Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Glu Ile Leu Pro Gly Ser Gly Ser Thr Asn Tyr Asn Glu 
    50                  55                  60                  


Lys Phe Lys Gly Lys Ala Thr Phe Thr Ala Asp Thr Ser Ser Asn Thr 
65                  70                  75                  80  


Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Gly Gly Asp Tyr Asp Glu Glu Tyr Tyr Leu Met Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120                 


<210>  105
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CRT4 variant 1 light chain

<400>  105

Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Arg Leu Leu Ile Tyr 
        35                  40                  45              


Asp Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Tyr Pro Leu Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys Leu Glu Ile Lys Arg Ala Ala 
            100                 105                 


<210>  106
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CRT4 variant 2 heavy chain

<400>  106

Met Ala Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Met Lys Pro 
1               5                   10                  15      


Gly Ala Ser Val Lys Ile Ser Cys Lys Ala Thr Gly Tyr Thr Phe Ser 
            20                  25                  30          


Ser Tyr Trp Ile Glu Trp Val Asn Arg Arg Pro Gly His Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Glu Ile Leu Pro Gly Ser Gly Ser Thr Asn Tyr Asn Glu 
    50                  55                  60                  


Lys Phe Lys Gly Lys Ala Thr Phe Thr Ala Asp Thr Ser Ser Asn Thr 
65                  70                  75                  80  


Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Gly Gly Asp Tyr Asp Glu Glu Tyr Tyr Leu Met Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val 
        115                 120         


<210>  107
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CRT4 variant 2 light chain

<400>  107

Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Arg Leu Leu Ile Tyr 
        35                  40                  45              


Asp Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Tyr Pro Leu Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys Leu Glu Ile Lys Arg Ala Ala Ala 
            100                 105                 110 


<210>  108
<211>  372
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CRT4 variant 1 heavy chain

<400>  108
atggcccagg ttcagctgca gcagtctgga gctgagctga tgaagcctgg ggcctcagtg       60

aagatatcct gcaaggctac tggctacaca ttcagtagct actggataga gtgggtaaac      120

cggaggcctg gacatggcct tgagtggatt ggagagattt tacctggaag tggtagtact      180

aattacaatg agaagttcaa gggcaaggcc acattcactg cagatacatc ctccaataca      240

gcctacatgc aactcagcag cctcacatct gaggactctg ccgtctatta ctgtgcgaga      300

gggggggatt acgacgaaga atactatctc atggactact ggggtcaagg caccactctc      360

acagtctcct ca                                                          372


<210>  109
<211>  329
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CRT4 variant 1 light chain nucleotide sequence

<400>  109
caaattgttc tcacccagtc tccagcaatc atgtctgcat ctccagggga gaaggtcacc       60

atgacctgca gtgccagctc aagtgtaagt tacatgtact ggtaccagca gaagccagga      120

tcctccccca gactcctgat ttatgacaca tccaacctgg cttctggagt ccctgttcgc      180

ttcagtggca gtgggtctgg gacctcttac tctctcacaa tcagccgaat ggaggctgaa      240

gatgctgcca cttattactg ccagcagtgg agtagttacc cgctcacgtt cggtgctggg      300

accaagctgg aaatcaaacg tgcggccgc                                        329


<210>  110
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CRT4 variant 2 heavy chain nucleotide sequence

<400>  110
atggcccagg ttcagctgca gcagtctgga gctgagctga tgaagcctgg ggcctcagtg       60

aagatatcct gcaaggctac tggctacaca ttcagtagct actggataga gtgggtaaac      120

cggaggcctg gacatggcct tgagtggatt ggagagattt tacctggaag tggtagtact      180

aattacaatg agaagttcaa gggcaaggcc acattcactg cagatacatc ctccaataca      240

gcctacatgc aactcagcag cctcacatct gaggactctg tcgtctatta ctgtgcgaga      300

gggggggatt acgacgaaga atactatctc atggactact ggggtcaagg caccactctc      360

acagtc                                                                 366


<210>  111
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CRT4 variant 2 light chain nucleotide sequence

<400>  111
caaattgttc tcacccagtc tccagcaatc atgtctgcat ctccagggga gaaggtcacc       60

atgacctgca gtgccagctc aagtgtaagt tacatgtact ggtaccagca gaagccagga      120

tcctccccca gactcctgat ttatgacaca tccaacctgg cttctggagt ccctgttcgc      180

ttcagtggca gtgggtctgg gacctcttac tctctcacaa tcagccgaat ggaggctgaa      240

gatgctgcca cttattactg ccagcagtgg agtagttacc cgctcacgtt cggtgctggg      300

accaagctgg aaatcaaacg t                                                321


<210>  112
<211>  249
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CRT4 scFv

<400>  112

Met Ala Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Met Lys Pro 
1               5                   10                  15      


Gly Ala Ser Val Lys Ile Ser Cys Lys Ala Thr Gly Tyr Thr Phe Ser 
            20                  25                  30          


Ser Tyr Trp Ile Glu Trp Val Asn Arg Arg Pro Gly His Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Glu Ile Leu Pro Gly Ser Gly Ser Thr Asn Tyr Asn Glu 
    50                  55                  60                  


Lys Phe Lys Gly Lys Ala Thr Phe Thr Ala Asp Thr Ser Ser Asn Thr 
65                  70                  75                  80  


Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Val Val Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Gly Gly Asp Tyr Asp Glu Glu Tyr Tyr Leu Met Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ile Val Leu Thr 
    130                 135                 140                 


Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly Glu Lys Val Thr Met 
145                 150                 155                 160 


Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Tyr Trp Tyr Gln Gln 
                165                 170                 175     


Lys Pro Gly Ser Ser Pro Arg Leu Leu Ile Tyr Asp Thr Ser Asn Leu 
            180                 185                 190         


Ala Ser Gly Val Pro Val Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser 
        195                 200                 205             


Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu Asp Ala Ala Thr Tyr 
    210                 215                 220                 


Tyr Cys Gln Gln Trp Ser Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr 
225                 230                 235                 240 


Lys Leu Glu Ile Lys Arg Ala Ala Ala 
                245                 


<210>  113
<211>  747
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CRT4 scFv nucleotide sequence

<400>  113
atggcccagg ttcagctgca gcagtctgga gctgagctga tgaagcctgg ggcctcagtg       60

aagatatcct gcaaggctac tggctacaca ttcagtagct actggataga gtgggtaaac      120

cggaggcctg gacatggcct tgagtggatt ggagagattt tacctggaag tggtagtact      180

aattacaatg agaagttcaa gggcaaggcc acattcactg cagatacatc ctccaataca      240

gcctacatgc aactcagcag cctcacatct gaggactctg tcgtctatta ctgtgcgaga      300

gggggggatt acgacgaaga atactatctc atggactact ggggtcaagg caccactctc      360

acagtctcct caggtggagg cggttcaggc ggaggtggct ctggcggtgg cggatcgcaa      420

attgttctca cccagtctcc agcaatcatg tctgcatctc caggggagaa ggtcaccatg      480

acctgcagtg ccagctcaag tgtaagttac atgtactggt accagcagaa gccaggatcc      540

tcccccagac tcctgattta tgacacatcc aacctggctt ctggagtccc tgttcgcttc      600

agtggcagtg ggtctgggac ctcttactct ctcacaatca gccgaatgga ggctgaagat      660

gctgccactt attactgcca gcagtggagt agttacccgc tcacgttcgg tgctgggacc      720

aagctggaaa tcaaacgtgc ggccgca                                          747


<210>  114
<211>  493
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CRT4 CAR4

<400>  114

Met Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu Ala 
1               5                   10                  15      


Leu Leu Phe Pro Ser Met Ala Ser Met Ala Gln Val Gln Leu Gln Gln 
            20                  25                  30          


Ser Gly Ala Glu Leu Met Lys Pro Gly Ala Ser Val Lys Ile Ser Cys 
        35                  40                  45              


Lys Ala Thr Gly Tyr Thr Phe Ser Ser Tyr Trp Ile Glu Trp Val Asn 
    50                  55                  60                  


Arg Arg Pro Gly His Gly Leu Glu Trp Ile Gly Glu Ile Leu Pro Gly 
65                  70                  75                  80  


Ser Gly Ser Thr Asn Tyr Asn Glu Lys Phe Lys Gly Lys Ala Thr Phe 
                85                  90                  95      


Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr Met Gln Leu Ser Ser Leu 
            100                 105                 110         


Thr Ser Glu Asp Ser Val Val Tyr Tyr Cys Ala Arg Gly Gly Asp Tyr 
        115                 120                 125             


Asp Glu Glu Tyr Tyr Leu Met Asp Tyr Trp Gly Gln Gly Thr Thr Leu 
    130                 135                 140                 


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala 
                165                 170                 175     


Ser Pro Gly Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val 
            180                 185                 190         


Ser Tyr Met Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Arg Leu 
        195                 200                 205             


Leu Ile Tyr Asp Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe 
    210                 215                 220                 


Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met 
225                 230                 235                 240 


Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Tyr 
                245                 250                 255     


Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile Lys Arg Ala Ala 
            260                 265                 270         


Ala Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser 
        275                 280                 285             


Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro 
    290                 295                 300                 


Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly 
305                 310                 315                 320 


Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile 
                325                 330                 335     


Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met 
            340                 345                 350         


Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro 
        355                 360                 365             


Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe 
    370                 375                 380                 


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu 
385                 390                 395                 400 


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
                405                 410                 415     


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Gln Arg Arg 
            420                 425                 430         


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
        435                 440                 445             


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
    450                 455                 460                 


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
465                 470                 475                 480 


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490             


<210>  115
<211>  1413
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CRT4 CAR4 nucleotide sequence

<400>  115
atggcccagg ttcagctgca gcagtctgga gctgagctga tgaagcctgg ggcctcagtg       60

aagatatcct gcaaggctac tggctacaca ttcagtagct actggataga gtgggtaaac      120

cggaggcctg gacatggcct tgagtggatt ggagagattt tacctggaag tggtagtact      180

aattacaatg agaagttcaa gggcaaggcc acattcactg cagatacatc ctccaataca      240

gcctacatgc aactcagcag cctcacatct gaggactctg tcgtctatta ctgtgcgaga      300

gggggggatt acgacgaaga atactatctc atggactact ggggtcaagg caccactctc      360

acagtctcct caggtggagg cggttcaggc ggaggtggct ctggcggtgg cggatcgcaa      420

attgttctca cccagtctcc agcaatcatg tctgcatctc caggggagaa ggtcaccatg      480

acctgcagtg ccagctcaag tgtaagttac atgtactggt accagcagaa gccaggatcc      540

tcccccagac tcctgattta tgacacatcc aacctggctt ctggagtccc tgttcgcttc      600

agtggcagtg ggtctgggac ctcttactct ctcacaatca gccgaatgga ggctgaagat      660

gctgccactt attactgcca gcagtggagt agttacccgc tcacgttcgg tgctgggacc      720

aagctggaaa tcaaacgtgc ggccgcaatt gaagttatgt atcctcctcc ttacctagac      780

aatgagaaga gcaatggaac cattatccat gtgaaaggga aacacctttg tccaagtccc      840

ctatttcccg gaccttctaa gcccttttgg gtgctggtgg tggttggtgg agtcctggct      900

tgctatagct tgctagtaac agtggccttt attattttct gggtgaggag taagaggagc      960

aggctcctgc acagtgacta catgaacatg actccccgcc gccccgggcc cacccgcaag     1020

cattaccagc cctatgcccc accacgcgac ttcgcagcct atcgctccag agtgaagttc     1080

agcaggagcg cagacgcccc cgcgtaccag cagggccaga accagctcta taacgagctc     1140

aatctaggac gaagagagga gtacgatgtt ttggacaaga gacgtggccg ggaccctgag     1200

atggggggaa agccgcagag aaggaagaac cctcaggaag gcctgtacaa tgaactgcag     1260

aaagataaga tggcggaggc ctacagtgag attgggatga aaggcgagcg ccggaggggc     1320

aaggggcacg atggccttta ccagggtctc agtacagcca ccaaggacac ctacgacgcc     1380

cttcacatgc aggccctgcc ccctcgctaa taa                                  1413


<210>  116
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of heavy chain variant 1 of CRT5

<400>  116

Ala Arg Gly Gly Asp Tyr Asp Glu Glu Tyr Tyr Ala Met Asp 
1               5                   10                  


<210>  117
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDR3 heavy chain variant 1 of CRT5

<400>  117
gcaagagggg gggattacga cgaagaatac tatgctatgg ac                          42


<210>  118
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of heavy chain variant 2 of CRT5

<400>  118

Ala Arg Gly Gly Asp Tyr Asp Glu Glu Tyr Tyr Ala Met Asp Tyr 
1               5                   10                  15  


<210>  119
<211>  72
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence for CD8alpha transmembrane domain

<400>  119
atctacatct gggcgccctt ggccgggact tgtggggtcc ttctcctgtc actggttatc       60

accctttact gc                                                           72


<210>  120
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDR3 of heavy chain variant 2 of CRT5

<400>  120
gcaagagggg gggattacga cgaagaatac tatgctatgg actac                       45


<210>  121
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CRT5 heavy chain

<400>  121

Met Ala Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Met Lys Pro 
1               5                   10                  15      


Gly Ala Ser Val Lys Ile Ser Cys Lys Ala Thr Gly Tyr Thr Phe Ser 
            20                  25                  30          


Ser Tyr Trp Ile Glu Trp Val Asn Gln Arg Pro Gly His Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Glu Ile Leu Pro Gly Ser Gly Ser Thr Asn Tyr Asn Glu 
    50                  55                  60                  


Lys Phe Lys Gly Lys Ala Thr Phe Thr Ala Asp Thr Ser Ser Asn Thr 
65                  70                  75                  80  


Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Gly Gly Asp Tyr Asp Glu Glu Tyr Tyr Ala Met Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Ser Val Thr Leu 
        115                 120         


<210>  122
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CRT5 light chain

<400>  122

Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Arg Leu Leu Ile Tyr 
        35                  40                  45              


Asp Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu 
65                  70                  75                  80  


Asp Gly Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Tyr Pro Leu Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg 
            100                 105         


<210>  123
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence for CRT5 heavy chain

<400>  123
atggccgagg ttcagcttca gcagtctgga gctgagctga tgaagcctgg ggcctcagtg       60

aagatatcct gcaaggctac tggctacaca ttcagtagct actggataga gtgggtaaat      120

cagaggcctg gacatggcct tgagtggatt ggagagattt tacctggaag tggtagtact      180

aattacaatg agaagttcaa gggcaaggcc acattcactg cagatacatc ctccaacaca      240

gcctacatgc aactcagcag cctgacatct gaggactctg ccgtctatta ctgtgcaaga      300

gggggggatt acgacgaaga atactatgct atggactact ggggtcaagg aacctcagtc      360

accctc                                                                 366


<210>  124
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of CRT5 light chain

<400>  124
caaattgttc tcacccagtc tccagcaatc atgtctgcat ctccagggga gaaggtcacc       60

atgacctgca gtgccagctc aagtgtaagt tacatgtact ggtaccagca gaagccagga      120

tcctccccca gactcctgat ttatgacaca tccaacctgg cttctggagt ccctgttcgc      180

ttcagtggca gtgggtctgg gacctcttac tctctcacaa tcagccgaat ggaggctgaa      240

gatgctgcca cttattactg ccagcagtgg agtagttacc cgctcacgtt cggtgctggg      300

accaagctgg agctgaaacg t                                                321


<210>  125
<211>  249
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CRT5 scFv

<400>  125

Met Ala Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Met Lys Pro 
1               5                   10                  15      


Gly Ala Ser Val Lys Ile Ser Cys Lys Ala Thr Gly Tyr Thr Phe Ser 
            20                  25                  30          


Ser Tyr Trp Ile Glu Trp Val Asn Gln Arg Pro Gly His Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Glu Ile Leu Pro Gly Ser Gly Ser Thr Asn Tyr Asn Glu 
    50                  55                  60                  


Lys Phe Lys Gly Lys Ala Thr Phe Thr Ala Asp Thr Ser Ser Asn Thr 
65                  70                  75                  80  


Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Gly Gly Asp Tyr Asp Glu Glu Tyr Tyr Ala Met Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Ser Val Thr Leu Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ile Val Leu Thr 
    130                 135                 140                 


Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly Glu Lys Val Thr Met 
145                 150                 155                 160 


Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Tyr Trp Tyr Gln Gln 
                165                 170                 175     


Lys Pro Gly Ser Ser Pro Arg Leu Leu Ile Tyr Asp Thr Ser Asn Leu 
            180                 185                 190         


Ala Ser Gly Val Pro Val Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser 
        195                 200                 205             


Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu Asp Ala Ala Thr Tyr 
    210                 215                 220                 


Tyr Cys Gln Gln Trp Ser Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr 
225                 230                 235                 240 


Lys Leu Glu Leu Lys Arg Ala Ala Ala 
                245                 


<210>  126
<211>  747
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of CRT5 scFv

<400>  126
atggccgagg ttcagcttca gcagtctgga gctgagctga tgaagcctgg ggcctcagtg       60

aagatatcct gcaaggctac tggctacaca ttcagtagct actggataga gtgggtaaat      120

cagaggcctg gacatggcct tgagtggatt ggagagattt tacctggaag tggtagtact      180

aattacaatg agaagttcaa gggcaaggcc acattcactg cagatacatc ctccaacaca      240

gcctacatgc aactcagcag cctgacatct gaggactctg ccgtctatta ctgtgcaaga      300

gggggggatt acgacgaaga atactatgct atggactact ggggtcaagg aacctcagtc      360

accctctcct caggtggagg cggttcaggc ggaggtggct ctggcggtgg cggatcgcaa      420

attgttctca cccagtctcc agcaatcatg tctgcatctc caggggagaa ggtcaccatg      480

acctgcagtg ccagctcaag tgtaagttac atgtactggt accagcagaa gccaggatcc      540

tcccccagac tcctgattta tgacacatcc aacctggctt ctggagtccc tgttcgcttc      600

agtggcagtg ggtctgggac ctcttactct ctcacaatca gccgaatgga ggctgaagat      660

gctgccactt attactgcca gcagtggagt agttacccgc tcacgttcgg tgctgggacc      720

aagctggagc tgaaacgtgc ggccgca                                          747


<210>  127
<211>  493
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR5 CRT5 (oncostatin leader, scFv CRT5, CD28-CD3 portion)

<400>  127

Met Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu Ala 
1               5                   10                  15      


Leu Leu Phe Pro Ser Met Ala Ser Met Ala Glu Val Gln Leu Gln Gln 
            20                  25                  30          


Ser Gly Ala Glu Leu Met Lys Pro Gly Ala Ser Val Lys Ile Ser Cys 
        35                  40                  45              


Lys Ala Thr Gly Tyr Thr Phe Ser Ser Tyr Trp Ile Glu Trp Val Asn 
    50                  55                  60                  


Gln Arg Pro Gly His Gly Leu Glu Trp Ile Gly Glu Ile Leu Pro Gly 
65                  70                  75                  80  


Ser Gly Ser Thr Asn Tyr Asn Glu Lys Phe Lys Gly Lys Ala Thr Phe 
                85                  90                  95      


Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr Met Gln Leu Ser Ser Leu 
            100                 105                 110         


Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Gly Gly Asp Tyr 
        115                 120                 125             


Asp Glu Glu Tyr Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val 
    130                 135                 140                 


Thr Leu Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala 
                165                 170                 175     


Ser Pro Gly Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val 
            180                 185                 190         


Ser Tyr Met Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Arg Leu 
        195                 200                 205             


Leu Ile Tyr Asp Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe 
    210                 215                 220                 


Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met 
225                 230                 235                 240 


Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Tyr 
                245                 250                 255     


Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Ala Ala 
            260                 265                 270         


Ala Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser 
        275                 280                 285             


Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro 
    290                 295                 300                 


Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly 
305                 310                 315                 320 


Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile 
                325                 330                 335     


Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met 
            340                 345                 350         


Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro 
        355                 360                 365             


Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe 
    370                 375                 380                 


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu 
385                 390                 395                 400 


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
                405                 410                 415     


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Gln Arg Arg 
            420                 425                 430         


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
        435                 440                 445             


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
    450                 455                 460                 


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
465                 470                 475                 480 


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490             


<210>  128
<211>  1502
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence for CAr5 CRT5

<400>  128
atgggcgtgc tgctgaccca gaggaccctg ctgagcctgg tgctggccct gctgtttcca       60

tctatggcat cgatggccga ggttcagctt cagcagtctg gagctgagct gatgaagcct      120

ggggcctcag tgaagatatc ctgcaaggct actggctaca cattcagtag ctactggata      180

gagtgggtaa atcagaggcc tggacatggc cttgagtgga ttggagagat tttacctgga      240

agtggtagta ctaattacaa tgagaagttc aagggcaagg ccacattcac tgcagataca      300

tcctccaaca cagcctacat gcaactcagc agcctgacat ctgaggactc tgccgtctat      360

tactgtgcaa gaggggggga ttacgacgaa gaatactatg ctatggacta ctggggtcaa      420

ggaacctcag tcaccctctc ctcaggtgga ggcggttcag gcggaggtgg ctctggcggt      480

ggcggatcgc aaattgttct cacccagtct ccagcaatca tgtctgcatc tccaggggag      540

aaggtcacca tgacctgcag tgccagctca agtgtaagtt acatgtactg gtaccagcag      600

aagccaggat cctcccccag actcctgatt tatgacacat ccaacctggc ttctggagtc      660

cctgttcgct tcagtggcag tgggtctggg acctcttact ctctcacaat cagccgaatg      720

gaggctgaag atgctgccac ttattactgc cagcagtgga gtagttaccc gctcacgttc      780

ggtgctggga ccaagctgga gctgaaacgt gcggccgcaa ttgaagttat gtatcctcct      840

ccttacctag acaatgagaa gagcaatgga accattatcc atgtgaaagg gaaacacctt      900

tgtccaagtc ccctatttcc cggaccttct aagccctttt gggtgctggt ggtggttggt      960

ggagtcctgg cttgctatag cttgctagta acagtggcct ttattatttt ctgggtgagg     1020

agtaagagga gcaggctcct gcacagtgac tacatgaaca tgactccccg ccgccccggg     1080

cccacccgca agcattacca gccctatgcc ccaccacgcg acttcgcagc ctatcgctcc     1140

agagtgaagt tcagcaggag cgcagacgcc cccgcgtacc agcagggcca gaaccagctc     1200

tataacgagc tcaatctagg acgaagagag gagtacgatg ttttggacaa gagacgtggc     1260

cgggaccctg agatgggggg aaagccgcag agaaggaaga accctcagga aggcctgtac     1320

aatgaactgc agaaagataa gatggcggag gcctacagtg agattgggat gaaaggcgag     1380

cgccggaggg gcaaggggca cgatggcctt taccagggtc tcagtacagc caccaaggac     1440

acctacgacg cccttcacat gcaggccctg ccccctcgct aataaaagct taacacgagc     1500

ca                                                                    1502


<210>  129
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 of light chain of CRT2

<400>  129

Ser Tyr Met His Trp Phe 
1               5       


<210>  130
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of light chain of CRT2

<400>  130

Gln Gln Arg Ser Ser Tyr Pro Leu 
1               5               


<210>  131
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDR1 of light chain of CRT2

<400>  131
agttacatgc actggttc                                                     18


<210>  132
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDR3 of light chain of CRT2

<400>  132
cagcaaagga gtagttaccc cctc                                              24


<210>  133
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CRT2 light chain

<400>  133

Glu Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Phe Gln Gln Lys Pro Gly Thr Ser Pro Lys Leu Trp Ile Tyr 
        35                  40                  45              


Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Leu Thr 
                85                  90                  95      


Phe Gly Ala Pro Gly Lys Leu Glu Leu Lys Arg Ala Ala 
            100                 105                 


<210>  134
<211>  329
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of CRT2 light chain

<400>  134
gaaattgttc tcacccagtc tccagcaatc atgtctgcat ctccagggga gaaggtcacc       60

ataacctgca gtgccagctc aagtgtaagt tacatgcact ggttccagca gaagccaggc      120

acttctccca aactctggat ttatagcaca tccaacctgg cttctggagt ccctgctcgc      180

ttcagtggca gtggatctgg gacctcttac tctctcacaa tcagccgaat ggaggctgaa      240

gatgctgcca cttattactg ccagcaaagg agtagttacc ccctcacgtt cggtgctggg      300

accaagctgg agctgaaacg tgcggccgc                                        329


<210>  135
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Oncostatin M leader

<400>  135

Met Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu Ala 
1               5                   10                  15      


Leu Leu Phe Pro Ser Met Ala Ser 
            20                  


<210>  136
<211>  836
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR5 CRT5 with truncated CD34

<400>  136

Met Pro Arg Gly Trp Thr Ala Leu Cys Leu Leu Ser Leu Leu Pro Ser 
1               5                   10                  15      


Gly Phe Met Ser Leu Asp Asn Asn Gly Thr Ala Thr Pro Glu Leu Pro 
            20                  25                  30          


Thr Gln Gly Thr Phe Ser Asn Val Ser Thr Asn Val Ser Tyr Gln Glu 
        35                  40                  45              


Thr Thr Thr Pro Ser Thr Leu Gly Ser Thr Ser Leu His Pro Val Ser 
    50                  55                  60                  


Gln His Gly Asn Glu Ala Thr Thr Asn Ile Thr Glu Thr Thr Val Lys 
65                  70                  75                  80  


Phe Thr Ser Thr Ser Val Ile Thr Ser Val Tyr Gly Asn Thr Asn Ser 
                85                  90                  95      


Ser Val Gln Ser Gln Thr Ser Val Ile Ser Thr Val Phe Thr Thr Pro 
            100                 105                 110         


Ala Asn Val Ser Thr Pro Glu Thr Thr Leu Lys Pro Ser Leu Ser Pro 
        115                 120                 125             


Gly Asn Val Ser Asp Leu Ser Thr Thr Ser Thr Ser Leu Ala Thr Ser 
    130                 135                 140                 


Pro Thr Lys Pro Tyr Thr Ser Ser Ser Pro Ile Leu Ser Asp Ile Lys 
145                 150                 155                 160 


Ala Glu Ile Lys Cys Ser Gly Ile Arg Glu Val Lys Leu Thr Gln Gly 
                165                 170                 175     


Ile Cys Leu Glu Gln Asn Lys Thr Ser Ser Cys Ala Glu Phe Lys Lys 
            180                 185                 190         


Asp Arg Gly Glu Gly Leu Ala Arg Val Leu Cys Gly Glu Glu Gln Ala 
        195                 200                 205             


Asp Ala Asp Ala Gly Ala Gln Val Cys Ser Leu Leu Leu Ala Gln Ser 
    210                 215                 220                 


Glu Val Arg Pro Gln Cys Leu Leu Leu Val Leu Ala Asn Arg Thr Glu 
225                 230                 235                 240 


Ile Ser Ser Lys Leu Gln Leu Met Lys Lys His Gln Ser Asp Leu Lys 
                245                 250                 255     


Lys Leu Gly Ile Leu Asp Phe Thr Glu Gln Asp Val Ala Ser His Gln 
            260                 265                 270         


Ser Tyr Ser Gln Lys Thr Leu Ile Ala Leu Val Thr Ser Gly Ala Leu 
        275                 280                 285             


Leu Ala Val Leu Gly Ile Thr Gly Tyr Phe Leu Met Asn Arg Arg Ser 
    290                 295                 300                 


Trp Ser Pro Thr Gly Glu Arg Leu Glu Leu Glu Pro Val Asp Arg Val 
305                 310                 315                 320 


Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu 
                325                 330                 335     


Ser Asn Pro Gly Pro Gly Asn Met Gly Val Leu Leu Thr Gln Arg Thr 
            340                 345                 350         


Leu Leu Ser Leu Val Leu Ala Leu Leu Phe Pro Ser Met Ala Ser Met 
        355                 360                 365             


Ala Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Met Lys Pro Gly 
    370                 375                 380                 


Ala Ser Val Lys Ile Ser Cys Lys Ala Thr Gly Tyr Thr Phe Ser Ser 
385                 390                 395                 400 


Tyr Trp Ile Glu Trp Val Asn Gln Arg Pro Gly His Gly Leu Glu Trp 
                405                 410                 415     


Ile Gly Glu Ile Leu Pro Gly Ser Gly Ser Thr Asn Tyr Asn Glu Lys 
            420                 425                 430         


Phe Lys Gly Lys Ala Thr Phe Thr Ala Asp Thr Ser Ser Asn Thr Ala 
        435                 440                 445             


Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr 
    450                 455                 460                 


Cys Ala Arg Gly Gly Asp Tyr Asp Glu Glu Tyr Tyr Ala Met Asp Tyr 
465                 470                 475                 480 


Trp Gly Gln Gly Thr Ser Val Thr Leu Ser Ser Gly Gly Gly Gly Ser 
                485                 490                 495     


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ile Val Leu Thr Gln 
            500                 505                 510         


Ser Pro Ala Ile Met Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr 
        515                 520                 525             


Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Tyr Trp Tyr Gln Gln Lys 
    530                 535                 540                 


Pro Gly Ser Ser Pro Arg Leu Leu Ile Tyr Asp Thr Ser Asn Leu Ala 
545                 550                 555                 560 


Ser Gly Val Pro Val Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr 
                565                 570                 575     


Ser Leu Thr Ile Ser Arg Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr 
            580                 585                 590         


Cys Gln Gln Trp Ser Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys 
        595                 600                 605             


Leu Glu Leu Lys Arg Ala Ala Ala Ile Glu Val Met Tyr Pro Pro Pro 
    610                 615                 620                 


Tyr Leu Asp Asn Glu Lys Ser Asn Gly Thr Ile Ile His Val Lys Gly 
625                 630                 635                 640 


Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe 
                645                 650                 655     


Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu 
            660                 665                 670         


Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg 
        675                 680                 685             


Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro 
    690                 695                 700                 


Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala 
705                 710                 715                 720 


Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
                725                 730                 735     


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
            740                 745                 750         


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
        755                 760                 765             


Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
    770                 775                 780                 


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
785                 790                 795                 800 


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
                805                 810                 815     


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
            820                 825                 830         


Leu Pro Pro Arg 
        835     


<210>  137
<211>  2514
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of CAR5-CRT5 with truncated CD34

<400>  137
atgcctcgcg gctggacagc cctgtgcctg ctgtctctgc tgccatccgg cttcatgagc       60

ctggataata acggcacagc caccccagag ctgcctacac agggcacctt cagcaatgtg      120

tccacaaacg tgagctatca ggagaccaca accccttcta ccctgggatc cacaagcctg      180

caccccgtgt ctcagcacgg caacgaagcc accaccaaca tcaccgagac cacagtgaag      240

tttacctcca cctctgtgat tacctctgtg tacggaaata caaactccag cgtgcagtct      300

cagacatctg tgatctccac agtgtttaca acacctgcca atgtgtccac cccagagaca      360

accctgaagc ccagcctgtc tcctggaaat gtgtccgatc tgtctaccac ctccaccagc      420

ctggccacct ctcccaccaa gccctatacc tcctcttctc ccatcctgag cgatatcaaa      480

gccgagatca aatgcagcgg gattcgggaa gtgaaactga cacagggcat ctgcctggaa      540

cagaataaga catccagctg cgccgagttt aagaaagata gaggagaggg actggccagg      600

gtgctgtgtg gcgaagagca ggccgacgcc gatgccggcg cccaggtgtg ttccctgctg      660

ctggcccagt ctgaggtgcg cccccagtgc ctgctgctgg tgctggccaa tcggacagaa      720

attagcagca agctgcagct gatgaaaaaa caccagagcg atctgaaaaa gctgggcatc      780

ctggacttta ccgagcagga cgtggcctct caccagagct acagccagaa aacactgatc      840

gccctggtga ccagcggagc cctgctggcc gtgctgggca tcaccggata tttcctgatg      900

aataggcgca gctggagccc caccggcgag cggctggagc tggagcctgt cgaccgagtg      960

aagcagaccc tgaactttga tctgctgaag ctggccggcg acgtggagtc caaccccggg     1020

ccagggaata tgggcgtgct gctgacccag aggaccctgc tgagcctggt gctggccctg     1080

ctgtttccat ctatggcatc gatggccgag gttcagcttc agcagtctgg agctgagctg     1140

atgaagcctg gggcctcagt gaagatatcc tgcaaggcta ctggctacac attcagtagc     1200

tactggatag agtgggtaaa tcagaggcct ggacatggcc ttgagtggat tggagagatt     1260

ttacctggaa gtggtagtac taattacaat gagaagttca agggcaaggc cacattcact     1320

gcagatacat cctccaacac agcctacatg caactcagca gcctgacatc tgaggactct     1380

gccgtctatt actgtgcaag agggggggat tacgacgaag aatactatgc tatggactac     1440

tggggtcaag gaacctcagt caccctctcc tcaggtggag gcggttcagg cggaggtggc     1500

tctggcggtg gcggatcgca aattgttctc acccagtctc cagcaatcat gtctgcatct     1560

ccaggggaga aggtcaccat gacctgcagt gccagctcaa gtgtaagtta catgtactgg     1620

taccagcaga agccaggatc ctcccccaga ctcctgattt atgacacatc caacctggct     1680

tctggagtcc ctgttcgctt cagtggcagt gggtctggga cctcttactc tctcacaatc     1740

agccgaatgg aggctgaaga tgctgccact tattactgcc agcagtggag tagttacccg     1800

ctcacgttcg gtgctgggac caagctggag ctgaaacgtg cggccgcaat tgaagttatg     1860

tatcctcctc cttacctaga caatgagaag agcaatggaa ccattatcca tgtgaaaggg     1920

aaacaccttt gtccaagtcc cctatttccc ggaccttcta agcccttttg ggtgctggtg     1980

gtggttggtg gagtcctggc ttgctatagc ttgctagtaa cagtggcctt tattattttc     2040

tgggtgagga gtaagaggag caggctcctg cacagtgact acatgaacat gactccccgc     2100

cgccccgggc ccacccgcaa gcattaccag ccctatgccc caccacgcga cttcgcagcc     2160

tatcgctcca gagtgaagtt cagcaggagc gcagacgccc ccgcgtacca gcagggccag     2220

aaccagctct ataacgagct caatctagga cgaagagagg agtacgatgt tttggacaag     2280

agacgtggcc gggaccctga gatgggggga aagccgcaga gaaggaagaa ccctcaggaa     2340

ggcctgtaca atgaactgca gaaagataag atggcggagg cctacagtga gattgggatg     2400

aaaggcgagc gccggagggg caaggggcac gatggccttt accagggtct cagtacagcc     2460

accaaggaca cctacgacgc ccttcacatg caggccctgc cccctcgcta ataa           2514


<210>  138
<211>  836
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR1 CRT1 with truncated CD34

<400>  138

Met Pro Arg Gly Trp Thr Ala Leu Cys Leu Leu Ser Leu Leu Pro Ser 
1               5                   10                  15      


Gly Phe Met Ser Leu Asp Asn Asn Gly Thr Ala Thr Pro Glu Leu Pro 
            20                  25                  30          


Thr Gln Gly Thr Phe Ser Asn Val Ser Thr Asn Val Ser Tyr Gln Glu 
        35                  40                  45              


Thr Thr Thr Pro Ser Thr Leu Gly Ser Thr Ser Leu His Pro Val Ser 
    50                  55                  60                  


Gln His Gly Asn Glu Ala Thr Thr Asn Ile Thr Glu Thr Thr Val Lys 
65                  70                  75                  80  


Phe Thr Ser Thr Ser Val Ile Thr Ser Val Tyr Gly Asn Thr Asn Ser 
                85                  90                  95      


Ser Val Gln Ser Gln Thr Ser Val Ile Ser Thr Val Phe Thr Thr Pro 
            100                 105                 110         


Ala Asn Val Ser Thr Pro Glu Thr Thr Leu Lys Pro Ser Leu Ser Pro 
        115                 120                 125             


Gly Asn Val Ser Asp Leu Ser Thr Thr Ser Thr Ser Leu Ala Thr Ser 
    130                 135                 140                 


Pro Thr Lys Pro Tyr Thr Ser Ser Ser Pro Ile Leu Ser Asp Ile Lys 
145                 150                 155                 160 


Ala Glu Ile Lys Cys Ser Gly Ile Arg Glu Val Lys Leu Thr Gln Gly 
                165                 170                 175     


Ile Cys Leu Glu Gln Asn Lys Thr Ser Ser Cys Ala Glu Phe Lys Lys 
            180                 185                 190         


Asp Arg Gly Glu Gly Leu Ala Arg Val Leu Cys Gly Glu Glu Gln Ala 
        195                 200                 205             


Asp Ala Asp Ala Gly Ala Gln Val Cys Ser Leu Leu Leu Ala Gln Ser 
    210                 215                 220                 


Glu Val Arg Pro Gln Cys Leu Leu Leu Val Leu Ala Asn Arg Thr Glu 
225                 230                 235                 240 


Ile Ser Ser Lys Leu Gln Leu Met Lys Lys His Gln Ser Asp Leu Lys 
                245                 250                 255     


Lys Leu Gly Ile Leu Asp Phe Thr Glu Gln Asp Val Ala Ser His Gln 
            260                 265                 270         


Ser Tyr Ser Gln Lys Thr Leu Ile Ala Leu Val Thr Ser Gly Ala Leu 
        275                 280                 285             


Leu Ala Val Leu Gly Ile Thr Gly Tyr Phe Leu Met Asn Arg Arg Ser 
    290                 295                 300                 


Trp Ser Pro Thr Gly Glu Arg Leu Glu Leu Glu Pro Val Asp Arg Val 
305                 310                 315                 320 


Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu 
                325                 330                 335     


Ser Asn Pro Gly Pro Gly Asn Met Gly Val Leu Leu Thr Gln Arg Thr 
            340                 345                 350         


Leu Leu Ser Leu Val Leu Ala Leu Leu Phe Pro Ser Met Ala Ser Met 
        355                 360                 365             


Ala Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Met Lys Pro Gly 
    370                 375                 380                 


Ala Ser Val Lys Ile Ser Cys Lys Ala Thr Gly Tyr Thr Phe Ser Ser 
385                 390                 395                 400 


Tyr Trp Ile Glu Trp Val Lys Gln Arg Pro Gly His Gly Leu Glu Trp 
                405                 410                 415     


Ile Gly Glu Ile Leu Pro Gly Ser Gly Ser Thr Asn Tyr Asn Glu Lys 
            420                 425                 430         


Phe Lys Gly Lys Ala Thr Phe Thr Ala Asp Thr Ser Ser Asn Thr Ala 
        435                 440                 445             


Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr 
    450                 455                 460                 


Cys Ala Arg Gly Gly Asp Tyr Asp Glu Glu Tyr Tyr Val Met Asp Tyr 
465                 470                 475                 480 


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
                485                 490                 495     


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ile Val Leu Thr Gln 
            500                 505                 510         


Ser Pro Ala Ile Met Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr 
        515                 520                 525             


Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Tyr Trp Tyr Gln Gln Lys 
    530                 535                 540                 


Pro Gly Ser Ser Pro Arg Leu Leu Ile Tyr Asp Thr Ser Asn Leu Ala 
545                 550                 555                 560 


Ser Gly Val Pro Val Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr 
                565                 570                 575     


Ser Leu Thr Ile Ser Arg Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr 
            580                 585                 590         


Cys Gln Gln Trp Ser Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys 
        595                 600                 605             


Leu Glu Leu Lys Arg Ala Ala Ala Ile Glu Val Met Tyr Pro Pro Pro 
    610                 615                 620                 


Tyr Leu Asp Asn Glu Lys Ser Asn Gly Thr Ile Ile His Val Lys Gly 
625                 630                 635                 640 


Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe 
                645                 650                 655     


Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu 
            660                 665                 670         


Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg 
        675                 680                 685             


Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro 
    690                 695                 700                 


Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala 
705                 710                 715                 720 


Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
                725                 730                 735     


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
            740                 745                 750         


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
        755                 760                 765             


Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
    770                 775                 780                 


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
785                 790                 795                 800 


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
                805                 810                 815     


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
            820                 825                 830         


Leu Pro Pro Arg 
        835     


<210>  139
<211>  2515
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of CAR1 CRT1 with truncated CD34

<400>  139
atgcctcgcg gctggacagc cctgtgcctg ctgtctctgc tgccatccgg cttcatgagc       60

ctggataata acggcacagc caccccagag ctgcctacac agggcacctt cagcaatgtg      120

tccacaaacg tgagctatca ggagaccaca accccttcta ccctgggatc cacaagcctg      180

caccccgtgt ctcagcacgg caacgaagcc accaccaaca tcaccgagac cacagtgaag      240

tttacctcca cctctgtgat tacctctgtg tacggaaata caaactccag cgtgcagtct      300

cagacatctg tgatctccac agtgtttaca acacctgcca atgtgtccac cccagagaca      360

accctgaagc ccagcctgtc tcctggaaat gtgtccgatc tgtctaccac ctccaccagc      420

ctggccacct ctcccaccaa gccctatacc tcctcttctc ccatcctgag cgatatcaaa      480

gccgagatca aatgcagcgg gattcgggaa gtgaaactga cacagggcat ctgcctggaa      540

cagaataaga catccagctg cgccgagttt aagaaagata gaggagaggg actggccagg      600

gtgctgtgtg gcgaagagca ggccgacgcc gatgccggcg cccaggtgtg ttccctgctg      660

ctggcccagt ctgaggtgcg cccccagtgc ctgctgctgg tgctggccaa tcggacagaa      720

attagcagca agctgcagct gatgaaaaaa caccagagcg atctgaaaaa gctgggcatc      780

ctggacttta ccgagcagga cgtggcctct caccagagct acagccagaa aacactgatc      840

gccctggtga ccagcggagc cctgctggcc gtgctgggca tcaccggata tttcctgatg      900

aataggcgca gctggagccc caccggcgag cggctggagc tggagcctgt cgaccgagtg      960

aagcagaccc tgaactttga tctgctgaag ctggccggcg acgtggagtc caaccccggg     1020

ccagggaata tgggcgtgct gctgacccag aggaccctgc tgagcctggt gctggccctg     1080

ctgtttccat ctatggcatc gatggccgag gttcagcttc agcagtctgg agctgagctg     1140

atgaagcctg gggcctcagt gaagatatcc tgcaaggcta ctggctacac attcagtagc     1200

tactggatag agtgggtaaa gcagaggcct ggacatggcc ttgagtggat tggagagatt     1260

ttacctggaa gtggtagtac taattacaat gagaagttca agggcaaggc cacattcact     1320

gcagatacat cctccaacac agcctacatg caactcagca gcctgacatc tgaggactct     1380

gccgtctatt actgtgcaag agggggggat tacgacgaag aatactatgt catggactac     1440

tggggtcaag gaacctcagt cactgtctcc tcaggtggag gcggttcagg cggaggtggc     1500

tctggcggtg gcggatcgca aattgttctc acccagtctc cagcaatcat gtctgcatct     1560

ccaggggaga aggtcaccat gacctgcagt gccagctcaa gtgtaagtta catgtactgg     1620

taccagcaga agccaggatc ctcccccaga ctcctgattt atgacacatc caacctggct     1680

tctggagtcc ctgttcgctt cagtggcagt gggtctggga cctcttactc tctcacaatc     1740

agccgaatgg aggctgaaga tgctgccact tattactgcc agcagtggag tagttacccg     1800

ctcacgttcg gtgctgggac caagctggag ctgaaacgtg cggccgcaaa ttgaagttat     1860

gtatcctcct ccttacctag acaatgagaa gagcaatgga accattatcc atgtgaaagg     1920

gaaacacctt tgtccaagtc ccctatttcc cggaccttct aagccctttt gggtgctggt     1980

ggtggttggt ggagtcctgg cttgctatag cttgctagta acagtggcct ttattatttt     2040

ctgggtgagg agtaagagga gcaggctcct gcacagtgac tacatgaaca tgactccccg     2100

ccgccccggg cccacccgca agcattacca gccctatgcc ccaccacgcg acttcgcagc     2160

ctatcgctcc agagtgaagt tcagcaggag cgcagacgcc cccgcgtacc agcagggcca     2220

gaaccagctc tataacgagc tcaatctagg acgaagagag gagtacgatg ttttggacaa     2280

gagacgtggc cgggaccctg agatgggggg aaagccgcag agaaggaaga accctcagga     2340

aggcctgtac aatgaactgc agaaagataa gatggcggag gcctacagtg agattgggat     2400

gaaaggcgag cgccggaggg gcaaggggca cgatggcctt taccagggtc tcagtacagc     2460

caccaaggac acctacgacg cccttcacat gcaggccctg ccccctcgct aataa          2515


<210>  140
<211>  835
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR3 CRT3 with truncated CD34

<400>  140

Met Pro Arg Gly Trp Thr Ala Leu Cys Leu Leu Ser Leu Leu Pro Ser 
1               5                   10                  15      


Gly Phe Met Ser Leu Asp Asn Asn Gly Thr Ala Thr Pro Glu Leu Pro 
            20                  25                  30          


Thr Gln Gly Thr Phe Ser Asn Val Ser Thr Asn Val Ser Tyr Gln Glu 
        35                  40                  45              


Thr Thr Thr Pro Ser Thr Leu Gly Ser Thr Ser Leu His Pro Val Ser 
    50                  55                  60                  


Gln His Gly Asn Glu Ala Thr Thr Asn Ile Thr Glu Thr Thr Val Lys 
65                  70                  75                  80  


Phe Thr Ser Thr Ser Val Ile Thr Ser Val Tyr Gly Asn Thr Asn Ser 
                85                  90                  95      


Ser Val Gln Ser Gln Thr Ser Val Ile Ser Thr Val Phe Thr Thr Pro 
            100                 105                 110         


Ala Asn Val Ser Thr Pro Glu Thr Thr Leu Lys Pro Ser Leu Ser Pro 
        115                 120                 125             


Gly Asn Val Ser Asp Leu Ser Thr Thr Ser Thr Ser Leu Ala Thr Ser 
    130                 135                 140                 


Pro Thr Lys Pro Tyr Thr Ser Ser Ser Pro Ile Leu Ser Asp Ile Lys 
145                 150                 155                 160 


Ala Glu Ile Lys Cys Ser Gly Ile Arg Glu Val Lys Leu Thr Gln Gly 
                165                 170                 175     


Ile Cys Leu Glu Gln Asn Lys Thr Ser Ser Cys Ala Glu Phe Lys Lys 
            180                 185                 190         


Asp Arg Gly Glu Gly Leu Ala Arg Val Leu Cys Gly Glu Glu Gln Ala 
        195                 200                 205             


Asp Ala Asp Ala Gly Ala Gln Val Cys Ser Leu Leu Leu Ala Gln Ser 
    210                 215                 220                 


Glu Val Arg Pro Gln Cys Leu Leu Leu Val Leu Ala Asn Arg Thr Glu 
225                 230                 235                 240 


Ile Ser Ser Lys Leu Gln Leu Met Lys Lys His Gln Ser Asp Leu Lys 
                245                 250                 255     


Lys Leu Gly Ile Leu Asp Phe Thr Glu Gln Asp Val Ala Ser His Gln 
            260                 265                 270         


Ser Tyr Ser Gln Lys Thr Leu Ile Ala Leu Val Thr Ser Gly Ala Leu 
        275                 280                 285             


Leu Ala Val Leu Gly Ile Thr Gly Tyr Phe Leu Met Asn Arg Arg Ser 
    290                 295                 300                 


Trp Ser Pro Thr Gly Glu Arg Leu Glu Leu Glu Pro Val Asp Arg Val 
305                 310                 315                 320 


Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu 
                325                 330                 335     


Ser Asn Pro Gly Pro Gly Asn Met Gly Val Leu Leu Thr Gln Arg Thr 
            340                 345                 350         


Leu Leu Ser Leu Val Leu Ala Leu Leu Phe Pro Ser Met Ala Ser Met 
        355                 360                 365             


Ala Glu Val Gln Leu Gln Gln Ser Gly Thr Val Leu Ala Arg Pro Gly 
    370                 375                 380                 


Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser 
385                 390                 395                 400 


Tyr Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp 
                405                 410                 415     


Ile Gly Ala Ile Tyr Pro Gly Asn Ser Asp Thr Ser Tyr Asn Gln Lys 
            420                 425                 430         


Phe Lys Gly Lys Ala Lys Leu Thr Ala Val Thr Ser Thr Ser Thr Ala 
        435                 440                 445             


Tyr Met Glu Leu Ser Ser Leu Thr Asn Glu Asp Ser Ala Val Phe Tyr 
    450                 455                 460                 


Cys Thr His Tyr Tyr Gly Ser Asp Tyr Ala Met Asp Tyr Trp Gly Gln 
465                 470                 475                 480 


Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                485                 490                 495     


Gly Ser Gly Gly Gly Gly Ser Gln Ile Val Leu Thr Gln Ser Pro Ala 
            500                 505                 510         


Ile Met Ser Ala Ser Leu Gly Glu Arg Val Thr Met Thr Cys Thr Ala 
        515                 520                 525             


Ser Ser Ser Val Ser Ser Ser Tyr Leu His Trp Tyr Gln Gln Lys Pro 
    530                 535                 540                 


Gly Ser Ser Pro Lys Leu Trp Ile Tyr Ser Thr Ser Asn Leu Ala Ser 
545                 550                 555                 560 


Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser 
                565                 570                 575     


Leu Thr Ile Ser Ser Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys 
            580                 585                 590         


His Gln Tyr His Arg Ser Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu 
        595                 600                 605             


Glu Ile Lys Arg Ala Ala Ala Ile Glu Val Met Tyr Pro Pro Pro Tyr 
    610                 615                 620                 


Leu Asp Asn Glu Lys Ser Asn Gly Thr Ile Ile His Val Lys Gly Lys 
625                 630                 635                 640 


His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp 
                645                 650                 655     


Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val 
            660                 665                 670         


Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu 
        675                 680                 685             


Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr 
    690                 695                 700                 


Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr 
705                 710                 715                 720 


Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln 
                725                 730                 735     


Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu 
            740                 745                 750         


Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly 
        755                 760                 765             


Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
    770                 775                 780                 


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
785                 790                 795                 800 


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
                805                 810                 815     


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
            820                 825                 830         


Pro Pro Arg 
        835 


<210>  141
<211>  2512
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of CAR3 CRT3 with truncated CD34

<400>  141
atgcctcgcg gctggacagc cctgtgcctg ctgtctctgc tgccatccgg cttcatgagc       60

ctggataata acggcacagc caccccagag ctgcctacac agggcacctt cagcaatgtg      120

tccacaaacg tgagctatca ggagaccaca accccttcta ccctgggatc cacaagcctg      180

caccccgtgt ctcagcacgg caacgaagcc accaccaaca tcaccgagac cacagtgaag      240

tttacctcca cctctgtgat tacctctgtg tacggaaata caaactccag cgtgcagtct      300

cagacatctg tgatctccac agtgtttaca acacctgcca atgtgtccac cccagagaca      360

accctgaagc ccagcctgtc tcctggaaat gtgtccgatc tgtctaccac ctccaccagc      420

ctggccacct ctcccaccaa gccctatacc tcctcttctc ccatcctgag cgatatcaaa      480

gccgagatca aatgcagcgg gattcgggaa gtgaaactga cacagggcat ctgcctggaa      540

cagaataaga catccagctg cgccgagttt aagaaagata gaggagaggg actggccagg      600

gtgctgtgtg gcgaagagca ggccgacgcc gatgccggcg cccaggtgtg ttccctgctg      660

ctggcccagt ctgaggtgcg cccccagtgc ctgctgctgg tgctggccaa tcggacagaa      720

attagcagca agctgcagct gatgaaaaaa caccagagcg atctgaaaaa gctgggcatc      780

ctggacttta ccgagcagga cgtggcctct caccagagct acagccagaa aacactgatc      840

gccctggtga ccagcggagc cctgctggcc gtgctgggca tcaccggata tttcctgatg      900

aataggcgca gctggagccc caccggcgag cggctggagc tggagcctgt cgaccgagtg      960

aagcagaccc tgaactttga tctgctgaag ctggccggcg acgtggagtc caaccccggg     1020

ccagggaata tgggcgtgct gctgacccag aggaccctgc tgagcctggt gctggccctg     1080

ctgtttccat ctatggcatc gatggccgag gtccagctgc agcagtctgg gactgtgctg     1140

gcaaggcctg gggcttcagt gaagatgtcc tgcaaggctt ctggctacac ctttaccagc     1200

tactggatgc actgggtaaa acagaggcct ggacagggtc tggaatggat tggcgctatt     1260

tatcctggaa atagtgatac tagctacaac cagaagttca agggcaaggc caaactgact     1320

gcagtcacat ccaccagcac tgcctacatg gagctcagca gcctgacaaa tgaggactct     1380

gcggtctttt actgtacaca ttactacggt agtgactatg ctatggacta ctggggtcaa     1440

ggaacctcag tcactgtctc ctcaggtgga ggcggttcag gcggaggtgg ctctggcggt     1500

ggcggatcgc aaattgttct cacccagtct ccagcaatca tgtctgcatc tctaggggaa     1560

cgggtcacca tgacctgcac tgccagctca agtgtaagtt ccagttactt gcactggtac     1620

cagcagaagc caggatcctc ccccaaactc tggatttata gcacatccaa cctggcttct     1680

ggagtcccag ctcgcttcag tggcagtggg tctgggacct cttactctct cacaatcagc     1740

agcatggagg ctgaagatgc tgccacttat tactgccacc agtatcatcg ttccccacgg     1800

acgttcggtg gaggcaccaa gctggaaatc aaacgtgcgg ccgcaaattg aagttatgta     1860

tcctcctcct tacctagaca atgagaagag caatggaacc attatccatg tgaaagggaa     1920

acacctttgt ccaagtcccc tatttcccgg accttctaag cccttttggg tgctggtggt     1980

ggttggtgga gtcctggctt gctatagctt gctagtaaca gtggccttta ttattttctg     2040

ggtgaggagt aagaggagca ggctcctgca cagtgactac atgaacatga ctccccgccg     2100

ccccgggccc acccgcaagc attaccagcc ctatgcccca ccacgcgact tcgcagccta     2160

tcgctccaga gtgaagttca gcaggagcgc agacgccccc gcgtaccagc agggccagaa     2220

ccagctctat aacgagctca atctaggacg aagagaggag tacgatgttt tggacaagag     2280

acgtggccgg gaccctgaga tggggggaaa gccgcagaga aggaagaacc ctcaggaagg     2340

cctgtacaat gaactgcaga aagataagat ggcggaggcc tacagtgaga ttgggatgaa     2400

aggcgagcgc cggaggggca aggggcacga tggcctttac cagggtctca gtacagccac     2460

caaggacacc tacgacgccc ttcacatgca ggccctgccc cctcgctaat aa             2512


<210>  142
<211>  836
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR4 CRT4 with truncated CD34

<400>  142

Met Pro Arg Gly Trp Thr Ala Leu Cys Leu Leu Ser Leu Leu Pro Ser 
1               5                   10                  15      


Gly Phe Met Ser Leu Asp Asn Asn Gly Thr Ala Thr Pro Glu Leu Pro 
            20                  25                  30          


Thr Gln Gly Thr Phe Ser Asn Val Ser Thr Asn Val Ser Tyr Gln Glu 
        35                  40                  45              


Thr Thr Thr Pro Ser Thr Leu Gly Ser Thr Ser Leu His Pro Val Ser 
    50                  55                  60                  


Gln His Gly Asn Glu Ala Thr Thr Asn Ile Thr Glu Thr Thr Val Lys 
65                  70                  75                  80  


Phe Thr Ser Thr Ser Val Ile Thr Ser Val Tyr Gly Asn Thr Asn Ser 
                85                  90                  95      


Ser Val Gln Ser Gln Thr Ser Val Ile Ser Thr Val Phe Thr Thr Pro 
            100                 105                 110         


Ala Asn Val Ser Thr Pro Glu Thr Thr Leu Lys Pro Ser Leu Ser Pro 
        115                 120                 125             


Gly Asn Val Ser Asp Leu Ser Thr Thr Ser Thr Ser Leu Ala Thr Ser 
    130                 135                 140                 


Pro Thr Lys Pro Tyr Thr Ser Ser Ser Pro Ile Leu Ser Asp Ile Lys 
145                 150                 155                 160 


Ala Glu Ile Lys Cys Ser Gly Ile Arg Glu Val Lys Leu Thr Gln Gly 
                165                 170                 175     


Ile Cys Leu Glu Gln Asn Lys Thr Ser Ser Cys Ala Glu Phe Lys Lys 
            180                 185                 190         


Asp Arg Gly Glu Gly Leu Ala Arg Val Leu Cys Gly Glu Glu Gln Ala 
        195                 200                 205             


Asp Ala Asp Ala Gly Ala Gln Val Cys Ser Leu Leu Leu Ala Gln Ser 
    210                 215                 220                 


Glu Val Arg Pro Gln Cys Leu Leu Leu Val Leu Ala Asn Arg Thr Glu 
225                 230                 235                 240 


Ile Ser Ser Lys Leu Gln Leu Met Lys Lys His Gln Ser Asp Leu Lys 
                245                 250                 255     


Lys Leu Gly Ile Leu Asp Phe Thr Glu Gln Asp Val Ala Ser His Gln 
            260                 265                 270         


Ser Tyr Ser Gln Lys Thr Leu Ile Ala Leu Val Thr Ser Gly Ala Leu 
        275                 280                 285             


Leu Ala Val Leu Gly Ile Thr Gly Tyr Phe Leu Met Asn Arg Arg Ser 
    290                 295                 300                 


Trp Ser Pro Thr Gly Glu Arg Leu Glu Leu Glu Pro Val Asp Arg Val 
305                 310                 315                 320 


Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu 
                325                 330                 335     


Ser Asn Pro Gly Pro Gly Asn Met Gly Val Leu Leu Thr Gln Arg Thr 
            340                 345                 350         


Leu Leu Ser Leu Val Leu Ala Leu Leu Phe Pro Ser Met Ala Ser Met 
        355                 360                 365             


Ala Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Met Lys Pro Gly 
    370                 375                 380                 


Ala Ser Val Lys Ile Ser Cys Lys Ala Thr Gly Tyr Thr Phe Ser Ser 
385                 390                 395                 400 


Tyr Trp Ile Glu Trp Val Asn Arg Arg Pro Gly His Gly Leu Glu Trp 
                405                 410                 415     


Ile Gly Glu Ile Leu Pro Gly Ser Gly Ser Thr Asn Tyr Asn Glu Lys 
            420                 425                 430         


Phe Lys Gly Lys Ala Thr Phe Thr Ala Asp Thr Ser Ser Asn Thr Ala 
        435                 440                 445             


Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Val Val Tyr Tyr 
    450                 455                 460                 


Cys Ala Arg Gly Gly Asp Tyr Asp Glu Glu Tyr Tyr Leu Met Asp Tyr 
465                 470                 475                 480 


Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Gly Gly Gly Gly Ser 
                485                 490                 495     


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ile Val Leu Thr Gln 
            500                 505                 510         


Ser Pro Ala Ile Met Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr 
        515                 520                 525             


Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Tyr Trp Tyr Gln Gln Lys 
    530                 535                 540                 


Pro Gly Ser Ser Pro Arg Leu Leu Ile Tyr Asp Thr Ser Asn Leu Ala 
545                 550                 555                 560 


Ser Gly Val Pro Val Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr 
                565                 570                 575     


Ser Leu Thr Ile Ser Arg Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr 
            580                 585                 590         


Cys Gln Gln Trp Ser Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys 
        595                 600                 605             


Leu Glu Ile Lys Arg Ala Ala Ala Ile Glu Val Met Tyr Pro Pro Pro 
    610                 615                 620                 


Tyr Leu Asp Asn Glu Lys Ser Asn Gly Thr Ile Ile His Val Lys Gly 
625                 630                 635                 640 


Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe 
                645                 650                 655     


Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu 
            660                 665                 670         


Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg 
        675                 680                 685             


Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro 
    690                 695                 700                 


Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala 
705                 710                 715                 720 


Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
                725                 730                 735     


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
            740                 745                 750         


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
        755                 760                 765             


Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
    770                 775                 780                 


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
785                 790                 795                 800 


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
                805                 810                 815     


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
            820                 825                 830         


Leu Pro Pro Arg 
        835     


<210>  143
<211>  2515
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence for CAR4 CRT4 with truncated CD34

<400>  143
atgcctcgcg gctggacagc cctgtgcctg ctgtctctgc tgccatccgg cttcatgagc       60

ctggataata acggcacagc caccccagag ctgcctacac agggcacctt cagcaatgtg      120

tccacaaacg tgagctatca ggagaccaca accccttcta ccctgggatc cacaagcctg      180

caccccgtgt ctcagcacgg caacgaagcc accaccaaca tcaccgagac cacagtgaag      240

tttacctcca cctctgtgat tacctctgtg tacggaaata caaactccag cgtgcagtct      300

cagacatctg tgatctccac agtgtttaca acacctgcca atgtgtccac cccagagaca      360

accctgaagc ccagcctgtc tcctggaaat gtgtccgatc tgtctaccac ctccaccagc      420

ctggccacct ctcccaccaa gccctatacc tcctcttctc ccatcctgag cgatatcaaa      480

gccgagatca aatgcagcgg gattcgggaa gtgaaactga cacagggcat ctgcctggaa      540

cagaataaga catccagctg cgccgagttt aagaaagata gaggagaggg actggccagg      600

gtgctgtgtg gcgaagagca ggccgacgcc gatgccggcg cccaggtgtg ttccctgctg      660

ctggcccagt ctgaggtgcg cccccagtgc ctgctgctgg tgctggccaa tcggacagaa      720

attagcagca agctgcagct gatgaaaaaa caccagagcg atctgaaaaa gctgggcatc      780

ctggacttta ccgagcagga cgtggcctct caccagagct acagccagaa aacactgatc      840

gccctggtga ccagcggagc cctgctggcc gtgctgggca tcaccggata tttcctgatg      900

aataggcgca gctggagccc caccggcgag cggctggagc tggagcctgt cgaccgagtg      960

aagcagaccc tgaactttga tctgctgaag ctggccggcg acgtggagtc caaccccggg     1020

ccagggaata tgggcgtgct gctgacccag aggaccctgc tgagcctggt gctggccctg     1080

ctgtttccat ctatggcatc gatggcccag gttcagctgc agcagtctgg agctgagctg     1140

atgaagcctg gggcctcagt gaagatatcc tgcaaggcta ctggctacac attcagtagc     1200

tactggatag agtgggtaaa ccggaggcct ggacatggcc ttgagtggat tggagagatt     1260

ttacctggaa gtggtagtac taattacaat gagaagttca agggcaaggc cacattcact     1320

gcagatacat cctccaatac agcctacatg caactcagca gcctcacatc tgaggactct     1380

gtcgtctatt actgtgcgag agggggggat tacgacgaag aatactatct catggactac     1440

tggggtcaag gcaccactct cacagtctcc tcaggtggag gcggttcagg cggaggtggc     1500

tctggcggtg gcggatcgca aattgttctc acccagtctc cagcaatcat gtctgcatct     1560

ccaggggaga aggtcaccat gacctgcagt gccagctcaa gtgtaagtta catgtactgg     1620

taccagcaga agccaggatc ctcccccaga ctcctgattt atgacacatc caacctggct     1680

tctggagtcc ctgttcgctt cagtggcagt gggtctggga cctcttactc tctcacaatc     1740

agccgaatgg aggctgaaga tgctgccact tattactgcc agcagtggag tagttacccg     1800

ctcacgttcg gtgctgggac caagctggaa atcaaacgtg cggccgcaaa ttgaagttat     1860

gtatcctcct ccttacctag acaatgagaa gagcaatgga accattatcc atgtgaaagg     1920

gaaacacctt tgtccaagtc ccctatttcc cggaccttct aagccctttt gggtgctggt     1980

ggtggttggt ggagtcctgg cttgctatag cttgctagta acagtggcct ttattatttt     2040

ctgggtgagg agtaagagga gcaggctcct gcacagtgac tacatgaaca tgactccccg     2100

ccgccccggg cccacccgca agcattacca gccctatgcc ccaccacgcg acttcgcagc     2160

ctatcgctcc agagtgaagt tcagcaggag cgcagacgcc cccgcgtacc agcagggcca     2220

gaaccagctc tataacgagc tcaatctagg acgaagagag gagtacgatg ttttggacaa     2280

gagacgtggc cgggaccctg agatgggggg aaagccgcag agaaggaaga accctcagga     2340

aggcctgtac aatgaactgc agaaagataa gatggcggag gcctacagtg agattgggat     2400

gaaaggcgag cgccggaggg gcaaggggca cgatggcctt taccagggtc tcagtacagc     2460

caccaaggac acctacgacg cccttcacat gcaggccctg ccccctcgct aataa          2515


<210>  144
<211>  367
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Truncated CD34 plus peptide 2A linker

<400>  144

Met Pro Arg Gly Trp Thr Ala Leu Cys Leu Leu Ser Leu Leu Pro Ser 
1               5                   10                  15      


Gly Phe Met Ser Leu Asp Asn Asn Gly Thr Ala Thr Pro Glu Leu Pro 
            20                  25                  30          


Thr Gln Gly Thr Phe Ser Asn Val Ser Thr Asn Val Ser Tyr Gln Glu 
        35                  40                  45              


Thr Thr Thr Pro Ser Thr Leu Gly Ser Thr Ser Leu His Pro Val Ser 
    50                  55                  60                  


Gln His Gly Asn Glu Ala Thr Thr Asn Ile Thr Glu Thr Thr Val Lys 
65                  70                  75                  80  


Phe Thr Ser Thr Ser Val Ile Thr Ser Val Tyr Gly Asn Thr Asn Ser 
                85                  90                  95      


Ser Val Gln Ser Gln Thr Ser Val Ile Ser Thr Val Phe Thr Thr Pro 
            100                 105                 110         


Ala Asn Val Ser Thr Pro Glu Thr Thr Leu Lys Pro Ser Leu Ser Pro 
        115                 120                 125             


Gly Asn Val Ser Asp Leu Ser Thr Thr Ser Thr Ser Leu Ala Thr Ser 
    130                 135                 140                 


Pro Thr Lys Pro Tyr Thr Ser Ser Ser Pro Ile Leu Ser Asp Ile Lys 
145                 150                 155                 160 


Ala Glu Ile Lys Cys Ser Gly Ile Arg Glu Val Lys Leu Thr Gln Gly 
                165                 170                 175     


Ile Cys Leu Glu Gln Asn Lys Thr Ser Ser Cys Ala Glu Phe Lys Lys 
            180                 185                 190         


Asp Arg Gly Glu Gly Leu Ala Arg Val Leu Cys Gly Glu Glu Gln Ala 
        195                 200                 205             


Asp Ala Asp Ala Gly Ala Gln Val Cys Ser Leu Leu Leu Ala Gln Ser 
    210                 215                 220                 


Glu Val Arg Pro Gln Cys Leu Leu Leu Val Leu Ala Asn Arg Thr Glu 
225                 230                 235                 240 


Ile Ser Ser Lys Leu Gln Leu Met Lys Lys His Gln Ser Asp Leu Lys 
                245                 250                 255     


Lys Leu Gly Ile Leu Asp Phe Thr Glu Gln Asp Val Ala Ser His Gln 
            260                 265                 270         


Ser Tyr Ser Gln Lys Thr Leu Ile Ala Leu Val Thr Ser Gly Ala Leu 
        275                 280                 285             


Leu Ala Val Leu Gly Ile Thr Gly Tyr Phe Leu Met Asn Arg Arg Ser 
    290                 295                 300                 


Trp Ser Pro Thr Gly Glu Arg Leu Glu Leu Glu Pro Val Asp Arg Val 
305                 310                 315                 320 


Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu 
                325                 330                 335     


Ser Asn Pro Gly Pro Gly Asn Met Gly Val Leu Leu Thr Gln Arg Thr 
            340                 345                 350         


Leu Leu Ser Leu Val Leu Ala Leu Leu Phe Pro Ser Met Ala Ser 
        355                 360                 365         


<210>  145
<211>  1101
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence for truncated CD34 plus peptide 2A

<400>  145
atgcctcgcg gctggacagc cctgtgcctg ctgtctctgc tgccatccgg cttcatgagc       60

ctggataata acggcacagc caccccagag ctgcctacac agggcacctt cagcaatgtg      120

tccacaaacg tgagctatca ggagaccaca accccttcta ccctgggatc cacaagcctg      180

caccccgtgt ctcagcacgg caacgaagcc accaccaaca tcaccgagac cacagtgaag      240

tttacctcca cctctgtgat tacctctgtg tacggaaata caaactccag cgtgcagtct      300

cagacatctg tgatctccac agtgtttaca acacctgcca atgtgtccac cccagagaca      360

accctgaagc ccagcctgtc tcctggaaat gtgtccgatc tgtctaccac ctccaccagc      420

ctggccacct ctcccaccaa gccctatacc tcctcttctc ccatcctgag cgatatcaaa      480

gccgagatca aatgcagcgg gattcgggaa gtgaaactga cacagggcat ctgcctggaa      540

cagaataaga catccagctg cgccgagttt aagaaagata gaggagaggg actggccagg      600

gtgctgtgtg gcgaagagca ggccgacgcc gatgccggcg cccaggtgtg ttccctgctg      660

ctggcccagt ctgaggtgcg cccccagtgc ctgctgctgg tgctggccaa tcggacagaa      720

attagcagca agctgcagct gatgaaaaaa caccagagcg atctgaaaaa gctgggcatc      780

ctggacttta ccgagcagga cgtggcctct caccagagct acagccagaa aacactgatc      840

gccctggtga ccagcggagc cctgctggcc gtgctgggca tcaccggata tttcctgatg      900

aataggcgca gctggagccc caccggcgag cggctggagc tggagcctgt cgaccgagtg      960

aagcagaccc tgaactttga tctgctgaag ctggccggcg acgtggagtc caaccccggg     1020

ccagggaata tgggcgtgct gctgacccag aggaccctgc tgagcctggt gctggccctg     1080

ctgtttccat ctatggcatc g                                               1101


<210>  146
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  146

Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn 
1               5                   10                  15      


Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu 
            20                  25                  30          


Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly 
        35                  40                  45              


Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe 
    50                  55                  60                  


Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn 
65                  70                  75                  80  


Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr 
                85                  90                  95      


Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
            100                 105         


<210>  147
<211>  322
<212>  DNA
<213>  Homo sapiens

<400>  147
aattgaagtt atgtatcctc ctccttacct agacaatgag aagagcaatg gaaccattat       60

ccatgtgaaa gggaaacacc tttgtccaag tcccctattt cccggacctt ctaagccctt      120

ttgggtgctg gtggtggttg gtggagtcct ggcttgctat agcttgctag taacagtggc      180

ctttattatt ttctgggtga ggagtaagag gagcaggctc ctgcacagtg actacatgaa      240

catgactccc cgccgccccg ggcccacccg caagcattac cagccctatg ccccaccacg      300

cgacttcgca gcctatcgct cc                                               322


<210>  148
<211>  113
<212>  PRT
<213>  Homo sapiens

<400>  148

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
    50                  55                  60                  


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
65                  70                  75                  80  


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
                85                  90                  95      


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
            100                 105                 110         


Arg 
    


<210>  149
<211>  345
<212>  DNA
<213>  Homo sapiens

<400>  149
agagtgaagt tcagcaggag cgcagacgcc cccgcgtacc agcagggcca gaaccagctc       60

tataacgagc tcaatctagg acgaagagag gagtacgatg ttttggacaa gagacgtggc      120

cgggaccctg agatgggggg aaagccgcag agaaggaaga accctcagga aggcctgtac      180

aatgaactgc agaaagataa gatggcggag gcctacagtg agattgggat gaaaggcgag      240

cgccggaggg gcaaggggca cgatggcctt taccagggtc tcagtacagc caccaaggac      300

acctacgacg cccttcacat gcaggccctg ccccctcgct aataa                      345


<210>  150
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus sequence for CRT1, 3, 4 and 5 variant 1 heavy chain 
       CDR1


<220>
<221>  X
<222>  (1)..(1)
<223>  X is S or T

<220>
<221>  X
<222>  (5)..(5)
<223>  X is I or M

<220>
<221>  X
<222>  (6)..(6)
<223>  X is E or H

<400>  150

Xaa Ser Tyr Trp Xaa Xaa 
1               5       


<210>  151
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus sequence for CRT1, 3, 4 and 5 variant 2 heavy chain 
       CDR1


<220>
<221>  X
<222>  (5)..(5)
<223>  X is S or T

<400>  151

Gly Tyr Thr Phe Xaa Ser Tyr Trp 
1               5               


<210>  152
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus sequence for CRT1, 3, 4 and 5 variant 1 heavy chain 
       CDR2


<220>
<221>  X
<222>  (4)..(4)
<223>  X is E or A

<220>
<221>  X
<222>  (6)..(6)
<223>  X is L or Y

<220>
<221>  X
<222>  (9)..(9)
<223>  X is S or N

<220>
<221>  X
<222>  (10)..(10)
<223>  X is G orS

<220>
<221>  X
<222>  (11)..(11)
<223>  X is S or D

<220>
<221>  X
<222>  (13)..(13)
<223>  X is N or S

<400>  152

Trp Ile Gly Xaa Ile Xaa Pro Gly Xaa Xaa Xaa Thr Xaa 
1               5                   10              


<210>  153
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus sequence for CRT1, 3, 4 and 5 variant 2 heavy chain 
       CDR2


<220>
<221>  X
<222>  (2)..(2)
<223>  X is L or Y

<220>
<221>  X
<222>  (5)..(5)
<223>  X is S or N

<220>
<221>  X
<222>  (6)..(6)
<223>  X is G or S

<220>
<221>  X
<222>  (7)..(7)
<223>  X is S or D

<400>  153

Ile Xaa Pro Gly Xaa Xaa Xaa Thr 
1               5               


<210>  154
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus sequence for CRT1, 3, 4 and 5 variant 1 heavy chain 
       CDR3


<220>
<221>  X
<222>  (1)..(1)
<223>  X is A or T

<220>
<221>  X
<222>  (2)..(2)
<223>  X is R or H

<220>
<221>  X
<222>  (3)..(3)
<223>  X is G or no amino acid

<220>
<221>  X
<222>  (4)..(4)
<223>  X is G or no amino acid

<220>
<221>  X
<222>  (5)..(5)
<223>  X is D or no amino acid

<220>
<221>  X
<222>  (7)..(7)
<223>  X is D or Y

<220>
<221>  X
<222>  (8)..(8)
<223>  X is E or G

<220>
<221>  X
<222>  (9)..(9)
<223>  X is E or S

<220>
<221>  X
<222>  (10)..(10)
<223>  X is Y or D

<220>
<221>  X
<222>  (12)..(12)
<223>  X is V, A or L

<400>  154

Xaa Xaa Xaa Xaa Xaa Tyr Xaa Xaa Xaa Xaa Tyr Xaa Met Asp 
1               5                   10                  


<210>  155
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus sequence for CRT1, 3, 4 and 5 variant 2 heavy chain 
       CDR3


<220>
<221>  X
<222>  (1)..(1)
<223>  X is A or T

<220>
<221>  X
<222>  (2)..(2)
<223>  X is R or H

<220>
<221>  X
<222>  (3)..(3)
<223>  X is G or no amino acid

<220>
<221>  X
<222>  (4)..(4)
<223>  X is G or no amino acid

<220>
<221>  X
<222>  (5)..(5)
<223>  X is D or no amino acid

<220>
<221>  X
<222>  (7)..(7)
<223>  X is D or Y

<220>
<221>  X
<222>  (8)..(8)
<223>  X is E or G

<220>
<221>  X
<222>  (9)..(9)
<223>  X is E or S

<220>
<221>  X
<222>  (10)..(10)
<223>  X is Y or D

<220>
<221>  X
<222>  (12)..(12)
<223>  X is V, A or L

<400>  155

Xaa Xaa Xaa Xaa Xaa Tyr Xaa Xaa Xaa Xaa Tyr Xaa Met Asp Tyr 
1               5                   10                  15  


<210>  156
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus sequence for CRT1, 3, 4 and 5 variant 1 light chain 
       CDR1


<220>
<221>  X
<222>  (1)..(1)
<223>  X is S or no amino acid

<220>
<221>  X
<222>  (2)..(2)
<223>  X is S or no amino acid

<220>
<221>  X
<222>  (5)..(5)
<223>  X is M or L

<220>
<221>  X
<222>  (6)..(6)
<223>  X is Y or H

<400>  156

Xaa Xaa Ser Tyr Xaa Xaa Trp Tyr 
1               5               


<210>  157
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus sequence for CRT1, 3, 4, and 5 variant 2 light chain 
       CDR1


<220>
<221>  X
<222>  (5)..(5)
<223>  X is Y or S

<220>
<221>  X
<222>  (6)..(6)
<223>  X is S or no amino acid

<220>
<221>  X
<222>  (7)..(7)
<223>  X is Y or no amino acid

<400>  157

Ser Ser Val Ser Xaa Xaa Xaa 
1               5           


<210>  158
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus sequence for CRT1, 3, 4 and 5 variant 1 light chain 
       CDR2


<220>
<221>  X
<222>  (2)..(2)
<223>  X is L or W

<220>
<221>  X
<222>  (5)..(5)
<223>  X is D or S

<400>  158

Leu Xaa Ile Tyr Xaa Thr Ser Asn Leu Ala 
1               5                   10  


<210>  159
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  159

Lys Asp Pro Lys 
1               


<210>  160
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus sequence for CRT1, 3, 4 and 5 variant 1 light chain 
       CDR3


<220>
<221>  X
<222>  (1)..(1)
<223>  X is Q or H

<220>
<221>  X
<222>  (3)..(3)
<223>  X is W or Y

<220>
<221>  X
<222>  (4)..(4)
<223>  X is S or H

<220>
<221>  X
<222>  (5)..(5)
<223>  X is S or R

<220>
<221>  X
<222>  (6)..(6)
<223>  X is Y or S

<220>
<221>  X
<222>  (8)..(8)
<223>  X is L or R

<400>  160

Xaa Gln Xaa Xaa Xaa Xaa Pro Xaa 
1               5               


<210>  161
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus sequence for CRT1, 3, 4 and 5 variant 2 light chain 
       CDR3


<220>
<221>  X
<222>  (1)..(1)
<223>  X is Q or H

<220>
<221>  X
<222>  (3)..(3)
<223>  X is W or Y

<220>
<221>  X
<222>  (4)..(4)
<223>  X is S or H

<220>
<221>  X
<222>  (5)..(5)
<223>  X is S or R

<220>
<221>  X
<222>  (6)..(6)
<223>  X is Y or S

<220>
<221>  X
<222>  (8)..(8)
<223>  X is L or R

<220>
<221>  X
<222>  (10)..(10)
<223>  X is F or no amino acid

<400>  161

Xaa Gln Xaa Xaa Xaa Xaa Pro Xaa Thr Xaa 
1               5                   10  


<210>  162
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of CD8alpha leader

<400>  162
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccg                                                                     63


<210>  163
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CH2CH3 hinge

<400>  163

Asp Pro Ala Glu Pro Lys Ser Pro Asp Lys Thr His Thr Cys Pro Pro 
1               5                   10                  15      


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
            20                  25                  30          


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
        35                  40                  45              


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
    50                  55                  60                  


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
65                  70                  75                  80  


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
                85                  90                  95      


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
            100                 105                 110         


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
        115                 120                 125             


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
    130                 135                 140                 


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
145                 150                 155                 160 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
                165                 170                 175     


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
            180                 185                 190         


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
        195                 200                 205             


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
    210                 215                 220                 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Lys Asp Pro Lys 
225                 230                 235                 


<210>  164
<211>  703
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence for CH2CH3 hinge

<400>  164
aaaatcttgt gacaaaactc acacatgccc accgtgccca gcacctgaac tcctgggggg       60

accgtcagtc ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc      120

tgaggtcaca tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca agttcaactg      180

gtacgtggac ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacaa      240

cagcacgtac cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa      300

ggagtacaag tgcaaggtct ccaacaaagc cctcccagcc cccatcgaga aaaccatctc      360

caaagccaaa gggcagcccc gagaaccaca ggtgtacacc ctgcccccat cccgggatga      420

gctgaccaag aaccaggtca gcctgacctg cctggtcaaa ggcttctatc ccagcgacat      480

cgccgtggag tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt      540

gctggactcc gacggctcct tcttcctcta cagcaagctc accgtggaca agagcaggtg      600

gcagcagggg aacgtcttct catgctccgt gatgcatgag ggtctgcaca accactacac      660

gcagaagagc ctctccctgt ctccgggtaa agggccggcc gct                        703


<210>  165
<211>  55
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8alpha hinge

<400>  165

Phe Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro 
1               5                   10                  15      


Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu 
            20                  25                  30          


Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg 
        35                  40                  45              


Gly Leu Asp Phe Ala Cys Asp 
    50                  55  


<210>  166
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Shortened IgG hinge

<400>  166

Ala Glu Pro Lys Ser Pro Asp Lys Thr His Thr Cys Pro 
1               5                   10              


<210>  167
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 of heavy chain variable region of CRT2

<400>  167

Gly Phe Thr Phe Asn Thr Tyr Ala 
1               5               


<210>  168
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 of heavy chain variable region of CRT2

<400>  168

Ile Arg Ser Lys Ser Asn Asn Tyr Ala Thr 
1               5                   10  


<210>  169
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of heavy chain variable region of CRT2

<400>  169

Val Arg Glu Gly Val Tyr Tyr Tyr Gly Ser Ser Gly Tyr Tyr Ala Met 
1               5                   10                  15      


Asp Tyr 
        


<210>  170
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence encoding CDR1 of heavy chain of CRT2

<400>  170
ggtttcacct tcaataccta tgcc                                              24


<210>  171
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence encoding CDR2 of CRT2

<400>  171
ataagaagta aaagtaataa ttatgcaaca                                        30


<210>  172
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence encoding CDR3 of CRT

<400>  172
gtgagagaag gggtttatta ctacggtagt agtgggtact atgctatgga ctac             54


<210>  173
<211>  130
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable region of CRT2

<400>  173

Met Ala Glu Val Gln Gly Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
1               5                   10                  15      


Lys Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn 
            20                  25                  30          


Thr Tyr Ala Met His Trp Val Cys Gln Ala Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Val Ala Arg Ile Arg Ser Lys Ser Asn Asn Tyr Ala Thr Tyr Tyr 
    50                  55                  60                  


Ala Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Gln 
65                  70                  75                  80  


Ser Met Leu Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala 
                85                  90                  95      


Met Tyr Tyr Cys Val Arg Glu Gly Val Tyr Tyr Tyr Gly Ser Ser Gly 
            100                 105                 110         


Tyr Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser 
        115                 120                 125             


Ser Gly 
    130 


<210>  174
<211>  401
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence encoding CRT2 heavy chain variable region

<400>  174
gacgcttatc gatggccgag gtgcaggggg tggagtctgg tggaggattg gtgcagccta       60

aaggatcatt gaaactctca tgtgccgcct ctggtttcac cttcaatacc tatgccatgc      120

actgggtctg ccaggctcca ggaaagggtt tggaatgggt tgctcgcata agaagtaaaa      180

gtaataatta tgcaacatat tatgccgatt cagtgaaaga cagattcacc atctccagag      240

atgattcaca aagcatgctc tatctgcaaa tgaacaacct gaaaactgag gacacagcca      300

tgtattactg tgtgagagaa ggggtttatt actacggtag tagtgggtac tatgctatgg      360

actactgggg tcaaggaacc tcagtcaccg tctcctcagg t                          401


<210>  175
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv of CRT2

<400>  175

Met Ala Glu Val Gln Gly Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
1               5                   10                  15      


Lys Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn 
            20                  25                  30          


Thr Tyr Ala Met His Trp Val Cys Gln Ala Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Val Ala Arg Ile Arg Ser Lys Ser Asn Asn Tyr Ala Thr Tyr Tyr 
    50                  55                  60                  


Ala Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Gln 
65                  70                  75                  80  


Ser Met Leu Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala 
                85                  90                  95      


Met Tyr Tyr Cys Val Arg Glu Gly Val Tyr Tyr Tyr Gly Ser Ser Gly 
            100                 105                 110         


Tyr Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser 
        115                 120                 125             


Ser Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Glu Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro 
145                 150                 155                 160 


Gly Glu Lys Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr 
                165                 170                 175     


Met His Trp Phe Gln Gln Lys Pro Gly Thr Ser Pro Lys Leu Trp Ile 
            180                 185                 190         


Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly 
        195                 200                 205             


Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala 
    210                 215                 220                 


Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Leu 
225                 230                 235                 240 


Thr Phe Gly Ala Pro Gly Lys Leu Glu Leu Lys Arg Ala Ala 
                245                 250                 


<210>  176
<211>  781
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CRT2 scFv nucleotide

<400>  176
gacgcttatc gatggccgag gtgcaggggg tggagtctgg tggaggattg gtgcagccta       60

aaggatcatt gaaactctca tgtgccgcct ctggtttcac cttcaatacc tatgccatgc      120

actgggtctg ccaggctcca ggaaagggtt tggaatgggt tgctcgcata agaagtaaaa      180

gtaataatta tgcaacatat tatgccgatt cagtgaaaga cagattcacc atctccagag      240

atgattcaca aagcatgctc tatctgcaaa tgaacaacct gaaaactgag gacacagcca      300

tgtattactg tgtgagagaa ggggtttatt actacggtag tagtgggtac tatgctatgg      360

actactgggg tcaaggaacc tcagtcaccg tctcctcagg ttcctcaggt ggaggcggtt      420

caggcggagg tggctctggc ggtggcggat cggaaattgt tctcacccag tctccagcaa      480

tcatgtctgc atctccaggg gagaaggtca ccataacctg cagtgccagc tcaagtgtaa      540

gttacatgca ctggttccag cagaagccag gcacttctcc caaactctgg atttatagca      600

catccaacct ggcttctgga gtccctgctc gcttcagtgg cagtggatct gggacctctt      660

actctctcac aatcagccga atggaggctg aagatgctgc cacttattac tgccagcaaa      720

ggagtagtta ccccctcacg ttcggtgctg ggaccaagct ggagctgaaa cgtgcggccg      780

c                                                                      781


<210>  177
<211>  747
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CRT1 scFv human codon optimised sequence

<400>  177
atggcagagg tgcagctgca gcagagcgga gcagagctga tgaagccagg agcctctgtg       60

aagatcagct gtaaggccac cggctataca ttcagctcct actggatcga gtgggtgaag      120

cagcggcctg gccacggcct ggagtggatc ggagagatcc tgccaggcag cggctccacc      180

aactataatg agaagttcaa gggcaaggcc acctttacag ccgacacctc tagcaacaca      240

gcctacatgc agctgtcctc tctgacaagc gaggattccg ccgtgtacta ttgcgccagg      300

ggcggcgact atgatgagga gtactatgtg atggactact ggggccaggg cacctccgtg      360

accgtgagca gcggcggagg cggcagcgga ggaggaggct ccggcggcgg cggctctcag      420

atcgtgctga cccagagccc agcaatcatg tctgccagcc caggagagaa ggtgaccatg      480

acatgttccg cctctagctc cgtgagctac atgtattggt atcagcagaa gcccggctct      540

agccctcggc tgctgatcta tagaacctcc aatctggcat ctggcgtgcc cgcaaggttc      600

tccggctctg gcagcggcac ctcctactct ctgaccatcg gcacaatgga ggccgaggat      660

gccgccacat actattgcca gcagtggtcc tcttaccctc tgacctttgg cgccggcaca      720

aagctggaga tcaagcgcgc ggccgca                                          747


<210>  178
<211>  747
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CRT1 scFv codon optimised murine sequence

<400>  178
atggctgagg tgcagctgca gcagtccgga gctgagctga tgaagccagg cgcctctgtg       60

aagatcagct gtaaggccac cggctacaca ttcagctcct actggatcga gtgggtgaag      120

cagaggcctg gccacggact ggagtggatc ggagagatcc tgccaggcag cggcagcacc      180

aactacaacg agaagttcaa gggcaaggct acctttacag ccgacacctc tagcaacaca      240

gcttacatgc agctgtcctc tctgacaagc gaggatagcg ccgtgtacta ctgcgccagg      300

ggcggagact acgatgagga gtactacgtg atggactact ggggccaggg aacctctgtg      360

accgtgagca gcggaggagg aggaagcggc ggaggaggca gcggaggagg aggatctcag      420

atcgtgctga cccagagccc agctatcatg tctgccagcc ccggcgagaa ggtgaccatg      480

acatgtagcg cctctagctc cgtgtcctac atgtactggt atcagcagaa gcccggatct      540

agccctaggc tgctgatcta cagaacatcc aacctggctt ctggcgtgcc cgctcggttc      600

tccggctctg gaagcggcac ctcctactct ctgaccatcg gcacaatgga ggctgaggat      660

gccgctacat actactgcca gcagtggtcc tcttaccctc tgacctttgg agccggcaca      720

aagctggaga tcaagcgcgc ggccgca                                          747


<210>  179
<211>  762
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CRT2 scFV codon optimised human sequence

<400>  179
atggcagagg tgcagggagt ggagagcgga ggcggcctgg tgcagcctaa gggctccctg       60

aagctgtctt gcgccgccag cggcttcacc tttaacacat atgcaatgca ctgggtgtgc      120

caggcaccag gcaagggcct ggagtgggtg gcacggatca gaagcaagtc caacaattat      180

gccacctact atgccgacag cgtgaaggat aggttcacaa tctcccgcga cgattctcag      240

agcatgctgt acctgcagat gaacaatctg aagaccgagg acacagccat gtactattgc      300

gtgcgggagg gcgtgtacta ttacggcagc tccggctatt acgctatgga ctactggggc      360

cagggcacca gcgtgacagt gtctagcgga ggaggaggct ccggaggagg aggctctggc      420

ggcggcggca gcgagatcgt gctgacccag tccccagcaa tcatgtccgc ctctccagga      480

gagaaggtga ccatcacatg ctccgcctcc tctagcgtgt cttatatgca ctggttccag      540

cagaagcccg gcacctctcc taagctgtgg atctacagca catccaatct ggcatccggc      600

gtgcccgcaa ggttttctgg cagcggctcc ggcacctctt atagcctgac aatcagccgg      660

atggaggcag aggacgcagc aacctattac tgtcagcaga gatcctctta ccctctgacc      720

tttggcgccg gcacaaagct ggagctgaag cgcgcggccg ca                         762


<210>  180
<211>  762
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CRT2 scFv codon optimised human sequence

<400>  180
atggctgagg tgcagggagt ggagagcgga ggaggcctgg tgcagcctaa gggctccctg       60

aagctgtctt gcgccgctag cggattcacc tttaacacat acgctatgca ctgggtgtgc      120

caggctccag gaaagggcct ggagtgggtg gccaggatca gaagcaagtc caacaactac      180

gctacctact acgccgacag cgtgaaggat cggttcacaa tctcccgcga cgattctcag      240

agcatgctgt acctgcagat gaacaacctg aagaccgagg acacagctat gtactactgc      300

gtgcgggagg gcgtgtacta ctacggcagc tccggatact acgctatgga ctactgggga      360

cagggcacct ccgtgacagt gtctagcgga ggaggaggct ccggaggagg aggctctgga      420

ggcggaggca gcgagatcgt gctgacccag tctccagcta tcatgtccgc ctctcccggc      480

gagaaggtga ccatcacatg ctccgcctcc tctagcgtgt cttacatgca ctggttccag      540

cagaagcccg gcacctctcc taagctgtgg atctacagca catccaacct ggctagcgga      600

gtgcccgctc ggttttctgg aagcggctcc ggaacctctt acagcctgac aatctccagg      660

atggaggctg aggacgccgc tacatactac tgtcagcaga gatcctctta ccctctgacc      720

tttggcgccg gaacaaagct ggagctgaag cgcgcggccg ca                         762


<210>  181
<211>  744
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CRT3 scFv codon optimised human sequence

<400>  181
atggccgagg tgcagctgca gcagtctggc accgtgctgg ccaggcccgg agcaagcgtg       60

aagatgtcct gcaaggcctc tggctacacc ttcacaagct attggatgca ctgggtgaag      120

cagcgcccag gacagggcct ggagtggatc ggagcaatct accccggcaa ctccgacacc      180

tcttataatc agaagttcaa gggcaaggcc aagctgacag ccgtgacctc tacaagcacc      240

gcctacatgg agctgagcag cctgaccaac gaggatagcg ccgtgtttta ttgcacacac      300

tactatggct ccgactacgc tatggactat tggggccagg gcacctccgt gacagtgtct      360

agcggaggag gaggcagcgg aggaggaggc tccggcggcg gcggctctca gatcgtgctg      420

acccagagcc ctgccatcat gtccgcctct ctgggcgagc gggtgacaat gacctgtaca      480

gcctcctcta gcgtgtcctc tagctacctg cactggtatc agcagaagcc cggctcctct      540

cctaagctgt ggatctacag cacctccaat ctggcatccg gcgtgcctgc aaggttctct      600

ggcagcggct ccggcacctc ttacagcctg acaatcagca gcatggaggc agaggacgca      660

gcaacatact attgtcacca gtatcaccgg agcccaagaa cctttggcgg cggcacaaag      720

ctggagatca agcgggcggc cgca                                             744


<210>  182
<211>  744
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CRT3 scFv codon optimised murine sequence

<400>  182
atggccgagg tgcagctgca gcagtctggc accgtgctgg ctcggcccgg agctagcgtg       60

aagatgtcct gcaaggcttc tggctacacc ttcacaagct actggatgca ctgggtgaag      120

cagcgcccag gacagggcct ggagtggatc ggcgccatct accccggaaa ctccgacacc      180

tcttacaacc agaagttcaa gggcaaggct aagctgacag ccgtgacctc tacaagcacc      240

gcttacatgg agctgagcag cctgaccaac gaggatagcg ccgtgtttta ctgcacacac      300

tactacggct ccgactacgc tatggattac tggggacagg gcacctccgt gacagtgtct      360

agcggaggag gaggaagcgg cggaggcggc agcggaggag gaggatctca gatcgtgctg      420

acccagtctc ctgctatcat gtccgcctct ctgggcgaga gggtgacaat gacctgtaca      480

gcctcctcta gcgtgtcctc tagctacctg cactggtatc agcagaagcc cggctcctct      540

cctaagctgt ggatctacag cacctccaac ctggcttccg gagtgcctgc tcggttctct      600

ggaagcggct ccggaacctc ttacagcctg acaatcagca gcatggaggc tgaggacgcc      660

gctacatact actgtcacca gtaccacagg agcccaagaa cctttggcgg aggcacaaag      720

ctggagatca agagggcggc cgca                                             744


<210>  183
<211>  747
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CRT4 scFv codon optimised human sequence

<400>  183
atggcacagg tgcagctgca gcagagcgga gcagagctga tgaagccagg agcctctgtg       60

aagatcagct gtaaggccac cggctataca ttcagctcct actggatcga gtgggtgaac      120

agacggcccg gccacggcct ggagtggatc ggagagatcc tgccaggcag cggctccacc      180

aactataatg agaagttcaa gggcaaggcc acctttacag ccgacacctc tagcaataca      240

gcctacatgc agctgtcctc tctgacaagc gaggattccg tggtgtacta ttgcgccagg      300

ggcggcgact atgatgagga gtactatctg atggactact ggggccaggg caccacactg      360

accgtgagca gcggaggagg aggcagcgga ggaggaggct ccggcggcgg cggctctcag      420

atcgtgctga cacagtcccc agcaatcatg tctgccagcc caggagagaa ggtgaccatg      480

acatgttccg cctctagctc cgtgagctac atgtattggt atcagcagaa gcccggctct      540

agccctaggc tgctgatcta tgacacctcc aacctggcat ctggcgtgcc cgtgcgcttc      600

tccggctctg gcagcggcac ctcctactct ctgacaatca gccggatgga ggcagaggat      660

gcagcaacct actattgcca gcagtggtcc tcttaccctc tgacctttgg cgccggcaca      720

aagctggaga tcaagcgggc ggccgca                                          747


<210>  184
<211>  747
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CRT4 scFv codon optimised murine sequence

<400>  184
atggctcagg tgcagctgca gcagtccgga gctgagctga tgaagccagg cgcctctgtg       60

aagatcagct gtaaggccac cggctacaca ttcagctcct actggatcga gtgggtgaac      120

aggaggcccg gccacggact ggagtggatc ggagagatcc tgccaggcag cggcagcacc      180

aactacaacg agaagttcaa gggcaaggct acctttacag ccgacacctc tagcaacaca      240

gcttacatgc agctgtcctc tctgacaagc gaggattccg tggtgtacta ctgcgccagg      300

ggcggagact acgatgagga gtactacctg atggactact ggggccaggg aaccacactg      360

accgtgagca gcggaggagg aggaagcggc ggaggaggca gcggaggagg aggatctcag      420

atcgtgctga cacagtctcc agctatcatg tctgccagcc ccggcgagaa ggtgaccatg      480

acatgtagcg ccagcagcag cgtgagctac atgtactggt atcagcagaa gcccggatct      540

agccctcggc tgctgatcta cgacacctcc aacctggctt ctggcgtgcc cgtgcgcttc      600

tccggctctg gaagcggcac ctcctactct ctgacaatca gcaggatgga ggctgaggat      660

gccgctacat actactgcca gcagtggtcc tcttaccctc tgacctttgg agccggcaca      720

aagctggaga tcaagagggc ggccgca                                          747


<210>  185
<211>  747
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CRT5 scFv codon optimised human sequence

<400>  185
atggcagagg tgcagctgca gcagtccgga gcagagctga tgaagccagg agcctctgtg       60

aagatcagct gtaaggccac cggctataca ttcagctcct actggatcga gtgggtgaac      120

cagcgccctg gccacggcct ggagtggatc ggagagatcc tgccaggcag cggctccacc      180

aactataatg agaagttcaa gggcaaggcc acctttacag ccgacacctc tagcaataca      240

gcctacatgc agctgtcctc tctgacaagc gaggattccg ccgtgtacta ttgcgccaga      300

ggcggcgact atgatgagga gtactatgct atggactact ggggccaggg cacctctgtg      360

accctgagca gcggaggagg aggcagcggc ggaggaggct ccggcggcgg cggctctcag      420

atcgtgctga cccagagccc agcaatcatg tctgccagcc caggagagaa ggtgaccatg      480

acatgtagcg cctctagctc cgtgtcctac atgtattggt atcagcagaa gcccggctct      540

agccctcggc tgctgatcta tgacacctcc aacctggcct ctggcgtgcc cgtgagattc      600

tccggctctg gcagcggcac ctcctactct ctgacaatca gcaggatgga ggccgaggat      660

gccgccacat actattgcca gcagtggtcc tcttaccctc tgacctttgg cgccggcaca      720

aagctggagc tgaagagggc ggccgca                                          747


<210>  186
<211>  747
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CRT5 scFv codon optimised murine sequence

<400>  186
atggctgagg tgcagctgca gcagtccgga gctgagctga tgaagccagg cgcctctgtg       60

aagatcagct gtaaggccac cggctacaca ttcagctcct actggatcga gtgggtgaac      120

cagcgccctg gccacggact ggagtggatc ggagagatcc tgccaggcag cggcagcacc      180

aactacaacg agaagttcaa gggcaaggct acctttacag ccgacacctc tagcaacaca      240

gcttacatgc agctgtcctc tctgacaagc gaggatagcg ccgtgtacta ctgcgccagg      300

ggcggagact acgatgagga gtactacgct atggactact ggggccaggg aacctctgtg      360

accctgagca gcggaggagg aggaagcggc ggaggaggca gcggaggagg aggatctcag      420

atcgtgctga cccagagccc agctatcatg tctgccagcc ccggcgagaa ggtgaccatg      480

acatgtagcg ccagcagcag cgtgagctac atgtactggt atcagcagaa gcccggatct      540

agccctaggc tgctgatcta cgacacctcc aacctggcct ctggcgtgcc cgtgagattc      600

tccggctctg gaagcggcac ctcctactct ctgacaatca gccggatgga ggctgaggat      660

gccgctacat actactgcca gcagtggtcc tcttaccctc tgacctttgg agccggcaca      720

aagctggagc tgaagcgggc ggccgca                                          747


<210>  187
<211>  141
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human TCR alpha chain constant region

<400>  187

Tyr Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser Lys 
1               5                   10                  15      


Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Gln Thr 
            20                  25                  30          


Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys Thr 
        35                  40                  45              


Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala Val Ala 
    50                  55                  60                  


Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn Ser 
65                  70                  75                  80  


Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser Cys Asp 
                85                  90                  95      


Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn Leu Asn Phe 
            100                 105                 110         


Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu Lys Val Ala 
        115                 120                 125             


Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
    130                 135                 140     


<210>  188
<211>  179
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human TCR beta chain constant region

<400>  188

Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala Val Phe Glu Pro 
1               5                   10                  15      


Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu Val Cys Leu 
            20                  25                  30          


Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser Trp Trp Val Asn 
        35                  40                  45              


Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln Pro Leu Lys 
    50                  55                  60                  


Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser Ser Arg Leu 
65                  70                  75                  80  


Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His Phe Arg Cys 
                85                  90                  95      


Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp Thr Gln Asp 
            100                 105                 110         


Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala Trp Gly Arg 
        115                 120                 125             


Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln Gln Gly Val Leu Ser 
    130                 135                 140                 


Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala 
145                 150                 155                 160 


Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val Lys Arg Lys Asp 
                165                 170                 175     


Ser Arg Gly 
            


<210>  189
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  WT1 epitope

<400>  189

Arg Met Phe Pro Asn Ala Pro Tyr Leu 
1               5                   


<210>  190
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 of WT1 TCR alpha chain

<400>  190

Ser Ser Tyr Ser Pro Ser 
1               5       


<210>  191
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 of WT1 TCR alpha chain

<400>  191

Tyr Thr Ser Ala Ala Thr Leu 
1               5           


<210>  192
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of WT1 TCR alpha chain

<400>  192

Val Val Ser Pro Phe Ser Gly Gly Gly Ala Asp Gly Leu Thr 
1               5                   10                  


<210>  193
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of WT1 TCR alpha chain

<400>  193

Ser Pro Phe Ser Gly Gly Gly Ala Asp Gly Leu Thr 
1               5                   10          


<210>  194
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 of WT1 TCR beta chain

<400>  194

Asp Phe Gln Ala Thr Thr 
1               5       


<210>  195
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 of WT1 TCR beta chain

<400>  195

Ser Asn Glu Gly Ser Lys Ala 
1               5           


<210>  196
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of WT1 TCR beta chain

<400>  196

Ser Ala Arg Asp Gly Gly Glu Gly 
1               5               


<210>  197
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of WT1 TCR beta chain

<400>  197

Arg Asp Gly Gly Glu Gly Ser Glu Thr Gln Tyr 
1               5                   10      


<210>  198
<211>  276
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human TCR alpha chain WT1

<400>  198

Met Leu Leu Leu Leu Val Pro Val Leu Glu Val Ile Phe Thr Leu Gly 
1               5                   10                  15      


Gly Thr Arg Ala Gln Ser Val Thr Gln Leu Asp Ser His Val Ser Val 
            20                  25                  30          


Ser Glu Gly Thr Pro Val Leu Leu Arg Cys Asn Tyr Ser Ser Ser Tyr 
        35                  40                  45              


Ser Pro Ser Leu Phe Trp Tyr Val Gln His Pro Asn Lys Gly Leu Gln 
    50                  55                  60                  


Leu Leu Leu Lys Tyr Thr Ser Ala Ala Thr Leu Val Lys Gly Ile Asn 
65                  70                  75                  80  


Gly Phe Glu Ala Glu Phe Lys Lys Ser Glu Thr Ser Phe His Leu Thr 
                85                  90                  95      


Lys Pro Ser Ala His Met Ser Asp Ala Ala Glu Tyr Phe Cys Val Val 
            100                 105                 110         


Ser Pro Phe Ser Gly Gly Gly Ala Asp Gly Leu Thr Phe Gly Lys Gly 
        115                 120                 125             


Thr His Leu Ile Ile Gln Pro Tyr Ile Gln Asn Pro Asp Pro Ala Val 
    130                 135                 140                 


Tyr Gln Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe 
145                 150                 155                 160 


Thr Asp Phe Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp 
                165                 170                 175     


Val Tyr Ile Thr Asp Lys Thr Val Leu Asp Met Arg Ser Met Asp Phe 
            180                 185                 190         


Lys Ser Asn Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys 
        195                 200                 205             


Ala Asn Ala Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro 
    210                 215                 220                 


Ser Pro Glu Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu 
225                 230                 235                 240 


Thr Asp Thr Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg 
                245                 250                 255     


Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg 
            260                 265                 270         


Leu Trp Ser Ser 
        275     


<210>  199
<211>  310
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human TCR beta chain WT1

<400>  199

Met Leu Leu Leu Leu Leu Leu Leu Gly Pro Gly Ser Gly Leu Gly Ala 
1               5                   10                  15      


Val Val Ser Gln His Pro Ser Trp Val Ile Cys Lys Ser Gly Thr Ser 
            20                  25                  30          


Val Lys Ile Glu Cys Arg Ser Leu Asp Phe Gln Ala Thr Thr Met Phe 
        35                  40                  45              


Trp Tyr Arg Gln Phe Pro Lys Gln Ser Leu Met Leu Met Ala Thr Ser 
    50                  55                  60                  


Asn Glu Gly Ser Lys Ala Thr Tyr Glu Gln Gly Val Glu Lys Asp Lys 
65                  70                  75                  80  


Phe Leu Ile Asn His Ala Ser Leu Thr Leu Ser Thr Leu Thr Val Thr 
                85                  90                  95      


Ser Ala His Pro Glu Asp Ser Ser Phe Tyr Ile Cys Ser Ala Arg Asp 
            100                 105                 110         


Gly Gly Glu Gly Ser Glu Thr Gln Tyr Phe Gly Pro Gly Thr Arg Leu 
        115                 120                 125             


Leu Val Leu Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala Val 
    130                 135                 140                 


Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu 
145                 150                 155                 160 


Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser Trp 
                165                 170                 175     


Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln 
            180                 185                 190         


Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser 
        195                 200                 205             


Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His 
    210                 215                 220                 


Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp 
225                 230                 235                 240 


Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala 
                245                 250                 255     


Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln Gln Gly 
            260                 265                 270         


Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr 
        275                 280                 285             


Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val Lys 
    290                 295                 300                 


Arg Lys Asp Ser Arg Gly 
305                 310 


<210>  200
<211>  276
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human TCR alpha chain (WT1) with Thr 48 to Cys substitution

<400>  200

Met Leu Leu Leu Leu Val Pro Val Leu Glu Val Ile Phe Thr Leu Gly 
1               5                   10                  15      


Gly Thr Arg Ala Gln Ser Val Thr Gln Leu Asp Ser His Val Ser Val 
            20                  25                  30          


Ser Glu Gly Thr Pro Val Leu Leu Arg Cys Asn Tyr Ser Ser Ser Tyr 
        35                  40                  45              


Ser Pro Ser Leu Phe Trp Tyr Val Gln His Pro Asn Lys Gly Leu Gln 
    50                  55                  60                  


Leu Leu Leu Lys Tyr Thr Ser Ala Ala Thr Leu Val Lys Gly Ile Asn 
65                  70                  75                  80  


Gly Phe Glu Ala Glu Phe Lys Lys Ser Glu Thr Ser Phe His Leu Thr 
                85                  90                  95      


Lys Pro Ser Ala His Met Ser Asp Ala Ala Glu Tyr Phe Cys Val Val 
            100                 105                 110         


Ser Pro Phe Ser Gly Gly Gly Ala Asp Gly Leu Thr Phe Gly Lys Gly 
        115                 120                 125             


Thr His Leu Ile Ile Gln Pro Tyr Ile Gln Asn Pro Asp Pro Ala Val 
    130                 135                 140                 


Tyr Gln Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe 
145                 150                 155                 160 


Thr Asp Phe Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp 
                165                 170                 175     


Val Tyr Ile Thr Asp Lys Cys Val Leu Asp Met Arg Ser Met Asp Phe 
            180                 185                 190         


Lys Ser Asn Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys 
        195                 200                 205             


Ala Asn Ala Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro 
    210                 215                 220                 


Ser Pro Glu Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu 
225                 230                 235                 240 


Thr Asp Thr Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg 
                245                 250                 255     


Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg 
            260                 265                 270         


Leu Trp Ser Ser 
        275     


<210>  201
<211>  310
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human TCR beta chain (WT1) with Ser 57 to Cys substitution

<400>  201

Met Leu Leu Leu Leu Leu Leu Leu Gly Pro Gly Ser Gly Leu Gly Ala 
1               5                   10                  15      


Val Val Ser Gln His Pro Ser Trp Val Ile Cys Lys Ser Gly Thr Ser 
            20                  25                  30          


Val Lys Ile Glu Cys Arg Ser Leu Asp Phe Gln Ala Thr Thr Met Phe 
        35                  40                  45              


Trp Tyr Arg Gln Phe Pro Lys Gln Ser Leu Met Leu Met Ala Thr Ser 
    50                  55                  60                  


Asn Glu Gly Ser Lys Ala Thr Tyr Glu Gln Gly Val Glu Lys Asp Lys 
65                  70                  75                  80  


Phe Leu Ile Asn His Ala Ser Leu Thr Leu Ser Thr Leu Thr Val Thr 
                85                  90                  95      


Ser Ala His Pro Glu Asp Ser Ser Phe Tyr Ile Cys Ser Ala Arg Asp 
            100                 105                 110         


Gly Gly Glu Gly Ser Glu Thr Gln Tyr Phe Gly Pro Gly Thr Arg Leu 
        115                 120                 125             


Leu Val Leu Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala Val 
    130                 135                 140                 


Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu 
145                 150                 155                 160 


Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser Trp 
                165                 170                 175     


Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro Gln 
            180                 185                 190         


Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser 
        195                 200                 205             


Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His 
    210                 215                 220                 


Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp 
225                 230                 235                 240 


Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala 
                245                 250                 255     


Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln Gln Gly 
            260                 265                 270         


Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr 
        275                 280                 285             


Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val Lys 
    290                 295                 300                 


Arg Lys Asp Ser Arg Gly 
305                 310 


<210>  202
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  WT1 epitope 235-243

<400>  202

Cys Met Thr Trp Asn Gln Met Asn Leu 
1               5                   


<210>  203
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Framework region

<400>  203

Phe Gly Lys Gly Thr His Leu Ile Ile Gln Pro 
1               5                   10      


<210>  204
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Framework region

<400>  204

Phe Gly Pro Gly Thr Arg Leu Leu Val Leu 
1               5                   10  


<210>  205
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus sequence of CRT5, 1 and 4 variant 1 heavy chain CDR3


<220>
<221>  X
<222>  (12)..(12)
<223>  X is A or V or L

<400>  205

Ala Arg Gly Gly Asp Tyr Asp Glu Glu Tyr Tyr Xaa Met Asp 
1               5                   10                  


<210>  206
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus sequence of CRT5, 1 and 4 variant 2 heavy chain CDR3


<220>
<221>  Xaa
<222>  (12)..(12)
<223>  Xaa is A or V or L

<400>  206

Ala Arg Gly Gly Asp Tyr Asp Glu Glu Tyr Tyr Xaa Met Asp Tyr 
1               5                   10                  15  


<210>  207
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus sequence of CRT5, 1 and 4 variants 1 and 2 heavy chain 
       CDR3


<220>
<221>  Xaa
<222>  (12)..(12)
<223>  Xaa is A or V or L

<220>
<221>  Xaa
<222>  (15)..(15)
<223>  Xaa is Y or no amino acid

<400>  207

Ala Arg Gly Gly Asp Tyr Asp Glu Glu Tyr Tyr Xaa Met Asp Xaa 
1               5                   10                  15  


<210>  208
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus of CRT5, 1 and 4 variants 1 and 2 light chain CDR3


<220>
<221>  Xaa
<222>  (9)..(9)
<223>  Xaa is T or no amino acid

<400>  208

Gln Gln Trp Ser Ser Tyr Pro Leu Xaa 
1               5                   


<210>  209
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus of CRT5, 1 and 4 variants 1 and 2 heavy chain CDR1


<220>
<221>  Xaa
<222>  (1)..(1)
<223>  Xaa is GYTF or no amino acid

<220>
<221>  Xaa
<222>  (6)..(6)
<223>  Xaa is IE or no amino acid

<400>  209

Xaa Ser Ser Tyr Trp Xaa 
1               5       


<210>  210
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus of CRT5, 1 and 4 variants 1 and 2 heavy chain CDR2


<220>
<221>  Xaa
<222>  (1)..(1)
<223>  Xaa is WIGE or no amino acid

<220>
<221>  Xaa
<222>  (10)..(10)
<223>  Xaa is N or no amino acid

<400>  210

Xaa Ile Leu Pro Gly Ser Gly Ser Thr Xaa 
1               5                   10  


<210>  211
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus sequenc of CRT5, 1, 4 and 3 variants 1 and 2 heavy 
       chains CDR1


<220>
<221>  Xaa
<222>  (1)..(1)
<223>  Xaa is GYTF or no amino acid

<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is S or T

<220>
<221>  Xaa
<222>  (6)..(6)
<223>  Xaa is I or M and E or H, or no amino acid

<400>  211

Xaa Xaa Ser Tyr Trp Xaa 
1               5       


<210>  212
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus of CRT5, 1, 4 and 3 variants 1 and 2 heavy chain CDR2


<220>
<221>  Xaa
<222>  (1)..(1)
<223>  Xaa is WIG and E or A, or no amino acid

<220>
<221>  Xaa
<222>  (3)..(3)
<223>  Xaa is L or Y

<220>
<221>  Xaa
<222>  (6)..(6)
<223>  Xaa is S or N

<220>
<221>  Xaa
<222>  (7)..(7)
<223>  Xaa is G or S

<220>
<221>  Xaa
<222>  (8)..(8)
<223>  Xaa is S or D

<220>
<221>  Xaa
<222>  (10)..(10)
<223>  Xaa is N or S or no amino acid

<400>  212

Xaa Ile Xaa Pro Gly Xaa Xaa Xaa Thr Xaa 
1               5                   10  


<210>  213
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus of CRT5, 1, 4 and 3 variants 1 and 2 heavy chain CDR3


<220>
<221>  Xaa
<222>  (1)..(1)
<223>  Xaa is A or T

<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is R or H

<220>
<221>  Xaa
<222>  (3)..(3)
<223>  Xaa is G or no amino acid

<220>
<221>  Xaa
<222>  (4)..(4)
<223>  Xaa is G or no amino acid

<220>
<221>  Xaa
<222>  (5)..(5)
<223>  Xaa is D or no amino acid

<220>
<221>  Xaa
<222>  (7)..(7)
<223>  Xaa is D or Y

<220>
<221>  Xaa
<222>  (8)..(8)
<223>  Xaa is E or G

<220>
<221>  Xaa
<222>  (9)..(9)
<223>  Xaa is E or S

<220>
<221>  Xaa
<222>  (10)..(10)
<223>  Xaa is Y or D

<220>
<221>  Xaa
<222>  (12)..(12)
<223>  Xaa is V or A or L

<220>
<221>  Xaa
<222>  (15)..(15)
<223>  Xaa is Y or no amino acid

<400>  213

Xaa Xaa Xaa Xaa Xaa Tyr Xaa Xaa Xaa Xaa Tyr Xaa Met Asp Xaa 
1               5                   10                  15  


<210>  214
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus of CRT5, 1, 4 and 3 variants 1 and 2 light chain CDR2


<220>
<221>  Xaa
<222>  (1)..(1)
<223>  Xaa is (L, L or W ,IY) or no amino acid

<220>
<221>  Xaa
<222>  (2)..(2)
<223>  D or S

<220>
<221>  Xaa
<222>  (5)..(5)
<223>  Xaa is NLA or no amino acid

<400>  214

Xaa Xaa Thr Ser Xaa 
1               5   


<210>  215
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus of CRT5, 1, 4, and 3 variants 1 and 2 light chain CDR3


<220>
<221>  Xaa
<222>  (1)..(1)
<223>  Xaa is Q or H

<220>
<221>  Xaa
<222>  (3)..(3)
<223>  Xaa is W or Y

<220>
<221>  Xaa
<222>  (4)..(4)
<223>  Xaa is S or H

<220>
<221>  Xaa
<222>  (5)..(5)
<223>  Xaa is S or R

<220>
<221>  Xaa
<222>  (6)..(6)
<223>  Xaa is Y or S

<220>
<221>  Xaa
<222>  (8)..(8)
<223>  Xaa is L or R

<220>
<221>  Xaa
<222>  (9)..(9)
<223>  Xaa is TF or no amino acid

<400>  215

Xaa Gln Xaa Xaa Xaa Xaa Pro Xaa Xaa 
1               5                   


<210>  216
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus of CRT3 variants 1 and 2 heavy chain CDR1


<220>
<221>  Xaa
<222>  (1)..(1)
<223>  Xaa is GYTF or no amino acid

<220>
<221>  Xaa
<222>  (6)..(6)
<223>  Xaa is MH or no amino acid

<400>  216

Xaa Thr Ser Tyr Trp Xaa 
1               5       


<210>  217
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus of CRT3 variants 1 and 2 heavy chain CDR2


<220>
<221>  Xaa
<222>  (1)..(1)
<223>  Xaa is WIGA or no amino acid

<220>
<221>  Xaa
<222>  (10)..(10)
<223>  Xaa is S or no amino acid

<400>  217

Xaa Ile Tyr Pro Gly Asn Ser Asp Thr Xaa 
1               5                   10  


<210>  218
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus of CRT3 variants 1 and 2 heavy chain CDR3


<220>
<221>  Xaa
<222>  (12)..(12)
<223>  Xaa is Y or no amino acid

<400>  218

Thr His Tyr Tyr Gly Ser Asp Tyr Ala Met Asp Xaa 
1               5                   10          


<210>  219
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus of CRT3 variants 1 and 2 light chain CDR1


<220>
<221>  Xaa
<222>  (1)..(1)
<223>  Xaa is SSV or no amino acid

<220>
<221>  Xaa
<222>  (6)..(6)
<223>  Xaa is LHWY or no amino acid

<400>  219

Xaa Ser Ser Ser Tyr Xaa 
1               5       


<210>  220
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus of CRT3 variants 1 and 2 light chain CDR2


<220>
<221>  Xaa
<222>  (1)..(1)
<223>  Xaa is LWIY or no amino acid

<220>
<221>  Xaa
<222>  (5)..(5)
<223>  Xaa is NLA or no amino acid

<400>  220

Xaa Ser Thr Ser Xaa 
1               5   


<210>  221
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus of CRT3 variants 1 and 2 light chain CDR3


<220>
<221>  Xaa
<222>  (9)..(9)
<223>  Xaa is T or no amino acid

<400>  221

His Gln Tyr His Arg Ser Pro Arg Xaa 
1               5                   


<210>  222
<211>  216
<212>  DNA
<213>  Mus musculus

<400>  222
actactacca agccagtgct gcgaactccc tcacctgtgc accctaccgg gacatctcag       60

ccccagagac cagaagattg tcggccccgt ggctcagtga aggggaccgg attggacttc      120

gcctgtgata tttacatctg ggcacccttg gccggaatct gcgtggccct tctgctgtcc      180

ttgatcatca ctctcatctg ctaccacagg agccga                                216


<210>  223
<211>  123
<212>  DNA
<213>  Mus musculus

<400>  223
aatagtagaa ggaacagact ccttcaaagt gactacatga acatgactcc ccggaggcct       60

gggctcactc gaaagcctta ccagccctac gcccctgcca gagactttgc agcgtaccgc      120

ccc                                                                    123


<210>  224
<211>  135
<212>  DNA
<213>  Mus musculus

<400>  224
aaatggatca ggaaaaaatt cccccacata ttcaagcaac catttaagaa gaccactgga       60

gcagctcaag aggaagatgc ttgtagctgc cgatgtccac aggaagaaga aggaggagga      120

ggaggctatg agctg                                                       135


<210>  225
<211>  334
<212>  DNA
<213>  Mus musculus

<400>  225
agagcaaaat tcagcaggag tgcagagact gctgccaacc tgcaggaccc caaccagctc       60

tacaatgagc tcaatctagg gcgaagagag gaatatgacg tcttggagaa gaagcgggct      120

cgggatccag agatgggagg caaacagcag aggaggagga acccccagga aggcgtatac      180

aatgcactgc agaaagacaa gatggcagaa gcctacagtg agatcggcac aaaaggcgag      240

aggcggagag gcaaggggca cgatggcctt taccagggtc tcagcactgc caccaaggac      300

acctatgatg ccctgcatat gcagaccctg gccc                                  334


<210>  226
<211>  108
<212>  DNA
<213>  Mus musculus

<400>  226
cggaaggctt ggagattgcc taacactccc aaaccttgtt ggggaaacag cttcaggacc       60

ccgatccagg aggaacacac agacgcacac tttactctgg ccaagatc                   108


<210>  227
<211>  752
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Murine CD8 alpha hinge-CD8 alpha transmembrane domain- CD28 
       costimulatory domain-CD3 zeta intracellular signalling domain

<400>  227
ggaggcacca agctggaaat caaacgtgcg gccgcaacta ctaccaagcc agtgctgcga       60

actccctcac ctgtgcaccc taccgggaca tctcagcccc agagaccaga agattgtcgg      120

ccccgtggct cagtgaaggg gaccggattg gacttcgcct gtgatattta catctgggca      180

cccttggccg gaatctgcgt ggcccttctg ctgtccttga tcatcactct catctgctac      240

cacaggagcc gaaatagtag aaggaacaga ctccttcaaa gtgactacat gaacatgact      300

ccccggaggc ctgggctcac tcgaaagcct taccagccct acgcccctgc cagagacttt      360

gcagcgtacc gccccagagc aaaattcagc aggagtgcag agactgctgc caacctgcag      420

gaccccaacc agctctacaa tgagctcaat ctagggcgaa gagaggaata tgacgtcttg      480

gagaagaagc gggctcggga tccagagatg ggaggcaaac agcagaggag gaggaacccc      540

caggaaggcg tatacaatgc actgcagaaa gacaagatgg cagaagccta cagtgagatc      600

ggcacaaaag gcgagaggcg gagaggcaag gggcacgatg gcctttacca gggtctcagc      660

actgccacca aggacaccta tgatgccctg catatgcaga ccctggcccc tcgctaataa      720

aagcttaaca cgagccatag atagaataaa ag                                    752


<210>  228
<211>  764
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Murine CD8alpha hinge-CD8alpha transmembrane domain-41BB 
       costimulatory domain- CD3 zeta intracellular signalling domain

<400>  228
ggaggcacca agctggaaat caaacgtgcg gccgcaacta ctaccaagcc agtgctgcga       60

actccctcac ctgtgcaccc taccgggaca tctcagcccc agagaccaga agattgtcgg      120

ccccgtggct cagtgaaggg gaccggattg gacttcgcct gtgatattta catctgggca      180

cccttggccg gaatctgcgt ggcccttctg ctgtccttga tcatcactct catctgctac      240

cacaggagcc gaaaatggat caggaaaaaa ttcccccaca tattcaagca accatttaag      300

aagaccactg gagcagctca agaggaagat gcttgtagct gccgatgtcc acaggaagaa      360

gaaggaggag gaggaggcta tgagctgaga gcaaaattca gcaggagtgc agagactgct      420

gccaacctgc aggaccccaa ccagctctac aatgagctca atctagggcg aagagaggaa      480

tatgacgtct tggagaagaa gcgggctcgg gatccagaga tgggaggcaa acagcagagg      540

aggaggaacc cccaggaagg cgtatacaat gcactgcaga aagacaagat ggcagaagcc      600

tacagtgaga tcggcacaaa aggcgagagg cggagaggca aggggcacga tggcctttac      660

cagggtctca gcactgccac caaggacacc tatgatgccc tgcatatgca gaccctggcc      720

cctcgctaat aaaagcttaa cacgagccat agatagaata aaag                       764


<210>  229
<211>  737
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Murine CD8alpha hinge-CD8alpha transmembrane domain-OX40 
       costimulatory domain-CD3 zeta intracellular signalling domain

<400>  229
ggaggcacca agctggaaat caaacgtgcg gccgcaacta ctaccaagcc agtgctgcga       60

actccctcac ctgtgcaccc taccgggaca tctcagcccc agagaccaga agattgtcgg      120

ccccgtggct cagtgaaggg gaccggattg gacttcgcct gtgatattta catctgggca      180

cccttggccg gaatctgcgt ggcccttctg ctgtccttga tcatcactct catctgctac      240

cacaggagcc gacggaaggc ttggagattg cctaacactc ccaaaccttg ttggggaaac      300

agcttcagga ccccgatcca ggaggaacac acagacgcac actttactct ggccaagatc      360

agagcaaaat tcagcaggag tgcagagact gctgccaacc tgcaggaccc caaccagctc      420

tacaatgagc tcaatctagg gcgaagagag gaatatgacg tcttggagaa gaagcgggct      480

cgggatccag agatgggagg caaacagcag aggaggagga acccccagga aggcgtatac      540

aatgcactgc agaaagacaa gatggcagaa gcctacagtg agatcggcac aaaaggcgag      600

aggcggagag gcaaggggca cgatggcctt taccagggtc tcagcactgc caccaaggac      660

acctatgatg ccctgcatat gcagaccctg gcccctcgct aataaaagct taacacgagc      720

catagataga ataaaag                                                     737


<210>  230
<211>  887
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Murine CD8alpha hinge-CD8alpha transmembrane domain-CD28 
       costimulatory domain- 41BB costimulatory domain-CD3 zeta 
       intracellular signalling domain

<400>  230
ggaggcacca agctggaaat caaacgtgcg gccgcaacta ctaccaagcc agtgctgcga       60

actccctcac ctgtgcaccc taccgggaca tctcagcccc agagaccaga agattgtcgg      120

ccccgtggct cagtgaaggg gaccggattg gacttcgcct gtgatattta catctgggca      180

cccttggccg gaatctgcgt ggcccttctg ctgtccttga tcatcactct catctgctac      240

cacaggagcc gaaatagtag aaggaacaga ctccttcaaa gtgactacat gaacatgact      300

ccccggaggc ctgggctcac tcgaaagcct taccagccct acgcccctgc cagagacttt      360

gcagcgtacc gccccaaatg gatcaggaaa aaattccccc acatattcaa gcaaccattt      420

aagaagacca ctggagcagc tcaagaggaa gatgcttgta gctgccgatg tccacaggaa      480

gaagaaggag gaggaggagg ctatgagctg agagcaaaat tcagcaggag tgcagagact      540

gctgccaacc tgcaggaccc caaccagctc tacaatgagc tcaatctagg gcgaagagag      600

gaatatgacg tcttggagaa gaagcgggct cgggatccag agatgggagg caaacagcag      660

aggaggagga acccccagga aggcgtatac aatgcactgc agaaagacaa gatggcagaa      720

gcctacagtg agatcggcac aaaaggcgag aggcggagag gcaaggggca cgatggcctt      780

taccagggtc tcagcactgc caccaaggac acctatgatg ccctgcatat gcagaccctg      840

gcccctcgct aataaaagct taacacgagc catagataga ataaaag                    887


<210>  231
<211>  860
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Murine CD8alpha hinge-CD8alpha transmembrane domain- CD28 and 
       OX40 costimulatory domains- CD3 zeta intracellular signalling 
       domain

<400>  231
ggaggcacca agctggaaat caaacgtgcg gccgcaacta ctaccaagcc agtgctgcga       60

actccctcac ctgtgcaccc taccgggaca tctcagcccc agagaccaga agattgtcgg      120

ccccgtggct cagtgaaggg gaccggattg gacttcgcct gtgatattta catctgggca      180

cccttggccg gaatctgcgt ggcccttctg ctgtccttga tcatcactct catctgctac      240

cacaggagcc gaaatagtag aaggaacaga ctccttcaaa gtgactacat gaacatgact      300

ccccggaggc ctgggctcac tcgaaagcct taccagccct acgcccctgc cagagacttt      360

gcagcgtacc gcccccggaa ggcttggaga ttgcctaaca ctcccaaacc ttgttgggga      420

aacagcttca ggaccccgat ccaggaggaa cacacagacg cacactttac tctggccaag      480

atcagagcaa aattcagcag gagtgcagag actgctgcca acctgcagga ccccaaccag      540

ctctacaatg agctcaatct agggcgaaga gaggaatatg acgtcttgga gaagaagcgg      600

gctcgggatc cagagatggg aggcaaacag cagaggagga ggaaccccca ggaaggcgta      660

tacaatgcac tgcagaaaga caagatggca gaagcctaca gtgagatcgg cacaaaaggc      720

gagaggcgga gaggcaaggg gcacgatggc ctttaccagg gtctcagcac tgccaccaag      780

gacacctatg atgccctgca tatgcagacc ctggcccctc gctaataaaa gcttaacacg      840

agccatagat agaataaaag                                                  860


<210>  232
<211>  872
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Murine CD8alpha hinge-CD8alpha transmembrane domain- 41BB and 
       OX40 costimulatory domains-CD3 zeta intracellular signalling 
       domain

<400>  232
ggaggcacca agctggaaat caaacgtgcg gccgcaacta ctaccaagcc agtgctgcga       60

actccctcac ctgtgcaccc taccgggaca tctcagcccc agagaccaga agattgtcgg      120

ccccgtggct cagtgaaggg gaccggattg gacttcgcct gtgatattta catctgggca      180

cccttggccg gaatctgcgt ggcccttctg ctgtccttga tcatcactct catctgctac      240

cacaggagcc gaaaatggat caggaaaaaa ttcccccaca tattcaagca accatttaag      300

aagaccactg gagcagctca agaggaagat gcttgtagct gccgatgtcc acaggaagaa      360

gaaggaggag gaggaggcta tgagctgcgg aaggcttgga gattgcctaa cactcccaaa      420

ccttgttggg gaaacagctt caggaccccg atccaggagg aacacacaga cgcacacttt      480

actctggcca agatcagagc aaaattcagc aggagtgcag agactgctgc caacctgcag      540

gaccccaacc agctctacaa tgagctcaat ctagggcgaa gagaggaata tgacgtcttg      600

gagaagaagc gggctcggga tccagagatg ggaggcaaac agcagaggag gaggaacccc      660

caggaaggcg tatacaatgc actgcagaaa gacaagatgg cagaagccta cagtgagatc      720

ggcacaaaag gcgagaggcg gagaggcaag gggcacgatg gcctttacca gggtctcagc      780

actgccacca aggacaccta tgatgccctg catatgcaga ccctggcccc tcgctaataa      840

aagcttaaca cgagccatag atagaataaa ag                                    872


