                         SEQUENCE LISTING

<110>  LALLEMAND HUNGARY LIQUIDITY MANAGEMENT LLC
 
<120>  REGULATION OF THE RAS/CAMP/PKA SIGNALING PATHWAY IN YEASTS

<130>  N410440WO

<150>  62/310251
<151>  2016-03-18

<160>  11    

<170>  PatentIn version 3.5

<210>  1
<211>  322
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  1

Met Pro Leu Asn Lys Ser Asn Ile Arg Glu Tyr Lys Leu Val Val Val 
1               5                   10                  15      


Gly Gly Gly Gly Val Gly Lys Ser Ala Leu Thr Ile Gln Leu Thr Gln 
            20                  25                  30          


Ser His Phe Val Asp Glu Tyr Asp Pro Thr Ile Glu Asp Ser Tyr Arg 
        35                  40                  45              


Lys Gln Val Val Ile Asp Asp Glu Val Ser Ile Leu Asp Ile Leu Asp 
    50                  55                  60                  


Thr Ala Gly Gln Glu Glu Tyr Ser Ala Met Arg Glu Gln Tyr Met Arg 
65                  70                  75                  80  


Asn Gly Glu Gly Phe Leu Leu Val Tyr Ser Ile Thr Ser Lys Ser Ser 
                85                  90                  95      


Leu Asp Glu Leu Met Thr Tyr Tyr Gln Gln Ile Leu Arg Val Lys Asp 
            100                 105                 110         


Thr Asp Tyr Val Pro Ile Val Val Val Gly Asn Lys Ser Asp Leu Glu 
        115                 120                 125             


Asn Glu Lys Gln Val Ser Tyr Gln Asp Gly Leu Asn Met Ala Lys Gln 
    130                 135                 140                 


Met Asn Ala Pro Phe Leu Glu Thr Ser Ala Lys Gln Ala Ile Asn Val 
145                 150                 155                 160 


Glu Glu Ala Phe Tyr Thr Leu Ala Arg Leu Val Arg Asp Glu Gly Gly 
                165                 170                 175     


Lys Tyr Asn Lys Thr Leu Thr Glu Asn Asp Asn Ser Lys Gln Thr Ser 
            180                 185                 190         


Gln Asp Thr Lys Gly Ser Gly Ala Asn Ser Val Pro Arg Asn Ser Gly 
        195                 200                 205             


Gly His Arg Lys Met Ser Asn Ala Ala Asn Gly Lys Asn Val Asn Ser 
    210                 215                 220                 


Ser Thr Thr Val Val Asn Ala Arg Asn Ala Ser Ile Glu Ser Lys Thr 
225                 230                 235                 240 


Gly Leu Ala Gly Asn Gln Ala Thr Asn Gly Lys Thr Gln Thr Asp Arg 
                245                 250                 255     


Thr Asn Ile Asp Asn Ser Thr Gly Gln Ala Gly Gln Ala Asn Ala Gln 
            260                 265                 270         


Ser Ala Asn Thr Val Asn Asn Arg Val Asn Asn Asn Ser Lys Ala Gly 
        275                 280                 285             


Gln Val Ser Asn Ala Lys Gln Ala Arg Lys Gln Gln Ala Ala Pro Gly 
    290                 295                 300                 


Gly Asn Thr Ser Glu Ala Ser Lys Ser Gly Ser Gly Gly Cys Cys Ile 
305                 310                 315                 320 


Ile Ser 
        


<210>  2
<211>  322
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  2

Met Pro Leu Asn Lys Ser Asn Ile Arg Glu Tyr Lys Leu Val Val Val 
1               5                   10                  15      


Gly Gly Gly Gly Val Gly Lys Ser Ala Leu Thr Ile Gln Leu Thr Gln 
            20                  25                  30          


Ser His Phe Val Asp Glu Tyr Asp Pro Thr Ile Glu Asp Ser Tyr Arg 
        35                  40                  45              


Lys Gln Val Val Ile Asp Asp Glu Val Ser Ile Leu Asp Ile Leu Asp 
    50                  55                  60                  


Thr Thr Gly Gln Glu Glu Tyr Ser Ala Met Arg Glu Gln Tyr Met Arg 
65                  70                  75                  80  


Asn Gly Glu Gly Phe Leu Leu Val Tyr Ser Ile Thr Ser Lys Ser Ser 
                85                  90                  95      


Leu Asp Glu Leu Met Thr Tyr Tyr Gln Gln Ile Leu Arg Val Lys Asp 
            100                 105                 110         


Thr Asp Tyr Val Pro Ile Val Val Val Gly Asn Lys Ser Asp Leu Glu 
        115                 120                 125             


Asn Glu Lys Gln Val Ser Tyr Gln Asp Gly Leu Asn Met Ala Lys Gln 
    130                 135                 140                 


Met Asn Ala Pro Phe Leu Glu Thr Ser Ala Lys Gln Ala Ile Asn Val 
145                 150                 155                 160 


Glu Glu Ala Phe Tyr Thr Leu Ala Arg Leu Val Arg Asp Glu Gly Gly 
                165                 170                 175     


Lys Tyr Asn Lys Thr Leu Thr Glu Asn Asp Asn Ser Lys Gln Thr Ser 
            180                 185                 190         


Gln Asp Thr Lys Gly Ser Gly Ala Asn Ser Val Pro Arg Asn Ser Gly 
        195                 200                 205             


Gly His Arg Lys Met Ser Asn Ala Ala Asn Gly Lys Asn Val Asn Ser 
    210                 215                 220                 


Ser Thr Thr Val Val Asn Ala Arg Asn Ala Ser Ile Glu Ser Lys Thr 
225                 230                 235                 240 


Gly Leu Ala Gly Asn Gln Ala Thr Asn Gly Lys Thr Gln Thr Asp Arg 
                245                 250                 255     


Thr Asn Ile Asp Asn Ser Thr Gly Gln Ala Gly Gln Ala Asn Ala Gln 
            260                 265                 270         


Ser Ala Asn Thr Val Asn Asn Arg Val Asn Asn Asn Ser Lys Ala Gly 
        275                 280                 285             


Gln Val Ser Asn Ala Lys Gln Ala Arg Lys Gln Gln Ala Ala Pro Gly 
    290                 295                 300                 


Gly Asn Thr Ser Glu Ala Ser Lys Ser Gly Ser Gly Gly Cys Cys Ile 
305                 310                 315                 320 


Ile Ser 
        


<210>  3
<211>  969
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid sequence coding for a mutated Ras2p


<220>
<221>  variation
<222>  (198)..(198)
<223>  n = a, c, t or g

<220>
<221>  misc_feature
<222>  (198)..(198)
<223>  n is a, c, g, or t

<400>  3
atgcctttga acaagtcgaa cataagagag tacaagctag tcgtcgttgg tggtggtggt       60

gttggtaaat ctgctttgac catacaattg acccaatcgc actttgtaga tgaatacgat      120

cccacaattg aggattcata caggaagcaa gtggtgattg atgatgaagt gtctatattg      180

gacattttgg atactacngg gcaggaagaa tactctgcta tgagggaaca atacatgcgc      240

aacggcgaag gattcctatt ggtttactct ataacatcca agtcgtctct tgatgagctt      300

atgacttact atcaacagat attgagagtc aaagataccg actatgttcc aattgtggtt      360

gttggtaaca aatctgattt agaaaacgaa aaacaggtct cttaccagga cgggttgaac      420

atggcaaagc aaatgaacgc tcctttcttg gagacatctg ctaagcaagc aatcaacgtg      480

gaagaggcgt tttacactct agcacgttta gttagagacg aaggcggcaa gtacaacaag      540

actttgacgg aaaatgacaa ctccaagcaa acttctcaag atacaaaagg gagcggtgcc      600

aactctgtgc ctagaaatag cggtggccac aggaagatga gcaatgctgc caacggtaaa      660

aatgtgaaca gtagcacaac tgtcgtgaat gccaggaatg caagcataga gagtaagaca      720

gggttggcag gcaaccaggc gacaaatggt aagacacaaa ctgatcgcac caatatagac      780

aattccacgg gccaagctgg tcaggccaac gctcaaagcg ctaatacggt taataatcgt      840

gtaaataata atagtaaggc cggtcaagtt tcaaatgcta aacaggctag gaagcagcaa      900

gctgcacccg gcggtaacac cagtgaagcc tccaagagcg gatcgggtgg ctgttgtatt      960

ataagttaa                                                              969


<210>  4
<211>  969
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  4
atgcctttga acaagtcgaa cataagagag tacaagctag tcgtcgttgg tggtggtggt       60

gttggtaaat ctgctttgac catacaattg acccaatcgc actttgtaga tgaatacgat      120

cccacaattg aggattcata caggaagcaa gtggtgattg atgatgaagt gtctatattg      180

gacattttgg atactgcagg gcaggaagaa tactctgcta tgagggaaca atacatgcgc      240

aacggcgaag gattcctatt ggtttactct ataacatcca agtcgtctct tgatgagctt      300

atgacttact atcaacagat attgagagtc aaagataccg actatgttcc aattgtggtt      360

gttggtaaca aatctgattt agaaaacgaa aaacaggtct cttaccagga cgggttgaac      420

atggcaaagc aaatgaacgc tcctttcttg gagacatctg ctaagcaagc aatcaacgtg      480

gaagaggcgt tttacactct agcacgttta gttagagacg aaggcggcaa gtacaacaag      540

actttgacgg aaaatgacaa ctccaagcaa acttctcaag atacaaaagg gagcggtgcc      600

aactctgtgc ctagaaatag cggtggccac aggaagatga gcaatgctgc caacggtaaa      660

aatgtgaaca gtagcacaac tgtcgtgaat gccaggaatg caagcataga gagtaagaca      720

gggttggcag gcaaccaggc gacaaatggt aagacacaaa ctgatcgcac caatatagac      780

aattccacgg gccaagctgg tcaggccaac gctcaaagcg ctaatacggt taataatcgt      840

gtaaataata atagtaaggc cggtcaagtt tcaaatgcta aacaggctag gaagcagcaa      900

gctgcacccg gcggtaacac cagtgaagcc tccaagagcg gatcgggtgg ctgttgtatt      960

ataagttaa                                                              969


<210>  5
<211>  969
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  5
atgcctttga acaagtcgaa cataagagag tacaagctag tcgtcgttgg tggtggtggt       60

gttggtaaat ctgctttgac catacaattg acccaatcgc actttgtaga tgaatacgat      120

cccacaattg aggattcata caggaagcaa gtggtgattg atgatgaagt gtctatattg      180

gacattttgg atactacagg gcaggaagaa tactctgcta tgagggaaca atacatgcgc      240

aacggcgaag gattcctatt ggtttactct ataacatcca agtcgtctct tgatgagctt      300

atgacttact atcaacagat attgagagtc aaagataccg actatgttcc aattgtggtt      360

gttggtaaca aatctgattt agaaaacgaa aaacaggtct cttaccagga cgggttgaac      420

atggcaaagc aaatgaacgc tcctttcttg gagacatctg ctaagcaagc aatcaacgtg      480

gaagaggcgt tttacactct agcacgttta gttagagacg aaggcggcaa gtacaacaag      540

actttgacgg aaaatgacaa ctccaagcaa acttctcaag atacaaaagg gagcggtgcc      600

aactctgtgc ctagaaatag cggtggccac aggaagatga gcaatgctgc caacggtaaa      660

aatgtgaaca gtagcacaac tgtcgtgaat gccaggaatg caagcataga gagtaagaca      720

gggttggcag gcaaccaggc gacaaatggt aagacacaaa ctgatcgcac caatatagac      780

aattccacgg gccaagctgg tcaggccaac gctcaaagcg ctaatacggt taataatcgt      840

gtaaataata atagtaaggc cggtcaagtt tcaaatgcta aacaggctag gaagcagcaa      900

gctgcacccg gcggtaacac cagtgaagcc tccaagagcg gatcgggtgg ctgttgtatt      960

ataagttaa                                                              969


<210>  6
<211>  9246
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  6
atgtcccagc ccactaagaa taagaagaaa gaacacggga ccgattccaa gtcatcccgc       60

atgactcgga cgttggttaa tcatattctt tttgaaagaa ttctcccgat ccttccggtg      120

gagtctaatc taagtaccta ttcggaagtg gaagagtatt cctcattcat ttcatgcaga      180

tctgtgctca ttaacgttac cgtttcccaa gatgcaaacg ctatggtgga aggcaccttg      240

gagttgatag aatcgcttct tcaagggcac gaaatcattt cagataagtg tagcagtgac      300

gttattgaat caatactgat tatactaaga ttgttaagtg atgcgctaga gtataattgg      360

caaaatcaag aaagccttca ttacaacgac atttcgactc acgtagaaca tgaccaagaa      420

cagaagtaca gaccaaagct taacagtatt ctgcccgact actcgtcgac tcattccaat      480

ggcaacaaac actttttcca ccagagcaaa cctcaggcac tgataccgga actggcatcg      540

aaattgcttg agagttgcgc gaagttgaag ttcaatacaa gaactttgca aattttacaa      600

aatatgatca gtcatgttca tggaaacatt ctaacgactt tgagttcctc gattcttccc      660

cgccacaaat cctatctgac aaggcacaac catccttctc attgtaaaat gattgactct      720

actctaggcc atattctccg atttgtagcg gcttccaatc cgtccgagta ttttgaattt      780

atcagaaaga gtgtgcaagt gcccgtaaca cagacacaca cacacacgca ttcacactcc      840

cattcacact ctttgccatc ttccgtttat aacagcatag tgccccactt tgatcttttc      900

agcttcatct atttaagcaa gcataatttt aagaaatact tggaactcat caaaaactta      960

tcggtgacgt taaggaaaac gatttatcat tgcctacttt tgcattacag cgccaaagca     1020

ataatgtttt ggataatggc taggcctgcg gaatattatg aactcttcaa cttattaaaa     1080

gataataaca atgaacactc gaaatcctta aacacgttaa accatacact tttcgaggag     1140

atccattcga cttttaatgt gaatagcatg ataaccacca atcaaaatgc tcatcaaggc     1200

tcatcttccc cttcgtcctc ctcgccatcg tcaccaccta gctcatcatc atcggataac     1260

aacaatcaaa acataatagc aaaatcctta agtcgtcagc tttctcacca ccagtcatac     1320

attcaacagc agtctgaaag aaaactacat tcttcatgga ctacaaactc tcaatcctct     1380

acttcactgt catcttcaac gtctaattca acaacaactg atttctctac tcacactcaa     1440

ccaggagaat acgacccttc cttaccagat actcccacga tgtctaacat cactattagt     1500

gcatcttcat tattatctca aactccaact ccaacaacac aattgcaaca gcggttgaac     1560

tcagcagctg cagccgccgc cgcagctgct tcaccatcga attccacccc aactggatac     1620

acagcagagc aacaaagtcg cgcttcatac gatgcacaca aaactggcca tactggtaag     1680

gattatgacg aacatttttt gtctgtcact cgtttggata atgttttgga gttatacacg     1740

cactttgatg atactgaggt actaccacac acatccgtac tgaagttttt aactactttg     1800

acaatgttcg atattgacct ttttaatgaa ttaaacgcta catcattcaa atatattcct     1860

gattgtacta tgcatcgtcc aaaagaaaga acaagttctt tcaataatac tgcacacgag     1920

acaggttccg aaaagacttc gggtataaaa catattacac aaggcttaaa gaaattaact     1980

tctttacctt cctcaaccaa aaaaactgta aaatttatga agatgttgct aagaaattta     2040

aatgggaatc aagctgtatc agatgttgcc ctcttagata caatgagggc cttactatca     2100

ttctttacaa tgacttctgc ggtctttctc gtggatagaa acttaccctc agtacttttt     2160

gccaagagac tcatccccat aatggggaca aatttaagcg tcggtcaaga ctggaattca     2220

aaaataaata acagtttgat ggtttgtttg aaaaaaaact ccaccacgtt tgttcaatta     2280

caattaatat tcttctcttc agctattcaa ttcgatcatg aattattact ggcacgtctg     2340

agcatcgata caatggccaa caatttaaac atgcagaagc tatgccttta tactgaagga     2400

ttcaggatat tcttcgacat accaagtaag aaggaattgc ggaaggcaat tgcggttaaa     2460

atttctaaat ttttcaaaac attattctcc attatagcag atattctttt acaagaattt     2520

ccgtattttg atgagcaaat caccgacata gttgcttcca ttcttgacgg tacaattatc     2580

aatgagtatg gtacgaagaa acatttcaag gggagctcac cctctttatg ttcgacaacc     2640

cggtcaagat caggatctac atctcaaagt tcaatgacac cagtttctcc gctgggactg     2700

gatactgata tacgtccaat gaacaccctg tctttagttg gttcaagtac ttcaagaaat     2760

tctgacaacg ttaattcatt aaacagttca ccaaagaact tgtcttctga tccatacttg     2820

tcacatcttg tggccccaag agcacgtcat gctttaggtg ggccatctag tattataagg     2880

aataaaatac cgactacatt gacttcacct ccaggaacgg aaaaatcttc accagtacaa     2940

cgtccgcaaa cggaaagcat cagtgccaca ccaatggcca taacaaattc tactccatta     3000

tcgtcggcag cattcggaat tcgatcgcct ttgcagaaaa taagaacgag gcgttattcc     3060

gatgaaagtt taggaaaatt catgaaatca acaaataatt acattcaaga acatttgata     3120

ccaaaagatt tgaatgaagc aactcttcaa gatgctagaa gaataatgat taatattttc     3180

agtattttta agagaccgaa tagttacttc atcattcctc acaatataaa ttcgaattta     3240

caatgggttt cgcaggattt tagaaatatt atgaaaccga ttttcgtcgc catcgtaagt     3300

ccggatgtag atttacagaa tactgctcaa tcattcatgg ataccttatt atcgaatgtt     3360

attacttatg gtgaatcaga tgagaatatc agtattgaag ggtatcatct tctttgcagt     3420

tacactgtaa cattatttgc aatgggcctt ttcgatttga aaattaataa tgaaaagcgt     3480

caaattctct tggatataac tgtcaagttt atgaaggtta gatcacattt agcagggatc     3540

gcggaggcct cacaccacat ggaatacata agtgattctg aaaaactcac ctttccgctg     3600

attatgggga ctgttggtag ggccctattt gtttcattat actctagtca acaaaaaatt     3660

gaaaagactt taaatattgc ttacacagag tatctttctg caatcaattt tcatgagagg     3720

aatattgatg atgctgataa aacttgggtt cataatattg agtttgtaga agcgatgtgt     3780

catgacaact acacaacttc tggttcaatt gctttccaaa ggaggacaag aaataatatt     3840

ttacgatttg ctactattcc taacgctatc ttacttgatt ctatgaggat gatctataag     3900

aagtggcata cttacacaca cagtaaaagt ttagaaaaac aagaacggaa cgacttcaga     3960

aatttcgcgg gtattttagc ctctttgtcg ggtatcctat tcatcaataa aaagatattg     4020

caagaaatgt atccatacct actcgacacc gtttcagaat tgaaaaaaaa tatagactct     4080

tttatctcaa aacaatgcca atggttaaac tatccggatt tattaacgag agaaaattca     4140

agagatattc taagtgtaga actgcatcct ttgtctttta acttactttt taataatttg     4200

aggctcaagt taaaagaact tgcttgttca gacttatcaa taccagaaaa tgaaagttcc     4260

tatgttttat tagaacaaat aatcaaaatg ctgcggacaa tcctaggtcg tgatgatgac     4320

aattatgtaa tgatgctttt ttccacagag attgtagatc ttattgattt attgacagat     4380

gaaataaaaa aaataccagc ctattgtcca aaatatctca aggcaattat tcaaatgacc     4440

aaaatgttca gtgccttgca gcactcagag gttaatttag gtgtcaaaaa tcattttcac     4500

gttaaaaata aatggttgag gcaaatcact gattggtttc aagtgagtat tgcgagagag     4560

tacgatttcg aaaacttgtc aaaacctcta aaagaaatgg atttggtaaa aagagacatg     4620

gatattctat acatagatac ggcaatcgaa gcttcaaccg ctattgcgta cctcacgaga     4680

catactttct tagagattcc acctgccgcg tcagatcccg aactatctcg atctaggtct     4740

gtgatatttg ggttttattt caacatctta atgaaaggcc ttgaaaaaag tagtgatcgt     4800

gacaattacc cagtattctt gaggcacaaa atgagtgtcc tcaacgacaa tgtaatactt     4860

tcattaacaa atctttcaaa caccaatgtt gatgcgagtt tgcagttcac cttaccgatg     4920

ggctattcgg gaaatcgaaa cattaggaat gcatttttgg aggtcttcat taatatcgtt     4980

acgaactatc ggacatacac ggctaaaact gaccttggaa aattagaggc agcagacaaa     5040

tttttgcgat atacgattga acatccccag ctatcgtcct ttggagcagc ggtttgtccc     5100

gctagcgata ttgatgctta tgctgctggc ttaataaatg catttgaaac gaggaatgcc     5160

acccacattg tagtggcaca gttgattaaa aatgaaattg aaaaatcttc cagacctacg     5220

gatatcctta gaagaaatag ctgtgctacg agatcattat ctatgctagc caggtccaag     5280

ggtaacgaat atttgattcg cactttgcaa ccattactaa aaaaaattat ccagaacaga     5340

gatttttttg aaattgagaa actaaaaccg gaagattcag atgctgaacg tcaaatagag     5400

ctcttcgtta aatacatgaa tgaattattg gaatccatat ccaactccgt atcttatttt     5460

ccccctcctt tattttatat ttgccaaaac atttataaag ttgcgtgtga aaaatttccg     5520

gatcacgcaa ttatcgccgc tgggtctttc gtgtttttac ggtttttttg tcctgcttta     5580

gtcagccctg attctgaaaa tatcatagat atttctcact tgagcgaaaa gcgtaccttc     5640

atcagcttgg ctaaagttat ccaaaatatt gccaatggct cagaaaattt ctccagatgg     5700

ccagctttgt gttcccaaaa ggattttctt aaagaatgta gcgatagaat tttcagattc     5760

ctagctgaac tttgtagaac agatcgcacg atagacatcc aagtgagaac agacccaacg     5820

ccaattgcat ttgactatca attccttcat tcctttgttt acctttacgg tcttgaggtg     5880

agaaggaatg tgctaaatga agcaaaacat gatgatggtg acattgatgg tgacgatttc     5940

tataagacca catttttact tattgatgat gttcttggcc aattaggcca acctaaaatg     6000

gaattttcca atgaaatacc aatatacata agagaacata tggacgacta tccggaactg     6060

tatgagttca tgaataggca cgcgttcaga aacattgaga cttcaacagc gtacagccca     6120

agcgttcacg agtccacctc aagtgaaggc attccaatta ttacgttaac aatgtcaaat     6180

ttctcagaca gacatgtgga cattgataca gttgcttaca agttcttgca aatttatgct     6240

cgaatctgga ccaccaaaca ctgtttaata atcgactgta cagaatttga cgagggaggg     6300

cttgatatga ggaaatttat ttctttggtt atgggactat taccagaagt tgcacccaaa     6360

aattgtatag gctgttacta ctttaacgta aacgagacat ttatggataa ttatggaaaa     6420

tgtttggaca aagacaacgt atatgtttcc tcgaaaattc ctcattattt cattaatagt     6480

aactctgatg aaggacttat gaaatctgtg ggtataactg gacaagggtt gaaggttctg     6540

caagatattc gtgtctctct gcatgatatc acgctttatg acgaaaaaag aaatagattt     6600

acgccggtat cgttgaaaat aggcgatatt tactttcaag tcttgcatga aactcctagg     6660

caatataaaa taagagacat gggtacttta ttcgacgtaa aattcaatga tgtctacgaa     6720

attagccgaa tatttgaagt acatgtttcg tcaataactg gagtggcagc tgaatttaca     6780

gtaacttttc aggacgagag aaggttgatt tttagtagtc cgaaatacct tgaaattgtg     6840

aagatgttct attacgcaca gatccggtta gaaagtgaat atgaaatgga taataattcg     6900

agtacctcct ccccaaattc aaacaacaag gacaaacagc agaaagagag aacaaaatta     6960

ttgtgccacc tactgttagt atctcttatt ggtctgtttg atgagagtaa aaaaatgaaa     7020

aacagttcgt ataacctaat agctgccact gaggcgtcat ttggcttgaa ctttggctcc     7080

cattttcatc gctctcccga ggtgtacgtc cccgaatata ctacaacatt tttaggtgtt     7140

attggaaagt ctcttgcaga gtctaatcca gaactcacag cctatatgtt tatctatgtt     7200

ttggaggcat tgaagaacaa cgtaattcct cacgtttaca tccctcatac catttgcggt     7260

ttgtcttatt ggatccctaa tttataccaa catgtgtatt tggctgatga tgaagaaggc     7320

cccgaaaaca tatctcacat tttccgaatt cttatcaggc tctctgtgag agagactgac     7380

tttaaagccg tatacatgca atatgtttgg ttgctacttt tagatgatgg ccgcttaact     7440

gacattatcg ttgatgaagt tattaatcat gcgttagaaa gagactccga aaaccgcgat     7500

tggaagaaaa caatatcgtt actgactgtc ctacccacta ctgaggttgc taataacatt     7560

attcaaaaaa tattggcaaa aattagatca tttttaccgt cattgaagtt agaagctatg     7620

acccaaagtt ggtctgaact aacaatatta gttaagataa gcatccacgt tttttttgaa     7680

acttctttgc tggtacagat gtacttacca gagatcctgt ttatcgtatc cttattaatt     7740

gatgttggtc caagggaact cagatcatca ctacaccagc tattaatgaa tgtatgccat     7800

tccttggcta ttgactcagc tttatcacaa gatcatagaa ataatctaga tgaaataagt     7860

gatatatttg cacatcaaaa ggtgaagttt atgtttgggt tcagcgagga caaaggacga     7920

attttacaga tttttagcgc ttcttctttt gcaagcaagt ttaatattct ggatttcttc     7980

atcaataata tattattgct gatggaatat tcttcaacgt acgaagcaaa cgtgtggaag     8040

acaagataca agaaatatgt cttggaatct gtgtttacaa gtaattcttt tctttcggca     8100

cgttcaatca tgattgttgg tataatgggt aaatcttaca taactgaagg gttatgcaag     8160

gctatgttaa ttgaaaccat gaaagttatc gccgaaccaa agattactga cgagcatctt     8220

ttcttagcca tatctcatat ttttacttat tccaaaattg ttgaaggttt ggatcccaac     8280

cttgacttaa tgaagcactt attttggttt tcaacactct tccttgaatc acgtcacccg     8340

ataatttttg agggtgccct tctctttgtg tcaaactgta taaggcgcct atacatggcc     8400

cagtttgaaa atgaaagcga aacatcattg ataagtactt tacttaaggg gagaaagttt     8460

gctcatacct ttttaagcaa gatagagaat cttagtggta ttgtttggaa tgaagataat     8520

tttacacaca ttctgatttt catcattaat aaaggactat ccaatccttt cattaagagt     8580

acggcttttg atttcttgaa gatgatgttt agaaactcct actttgagca tcaaatcaat     8640

cagaaatctg atcattattt gtgctatatg ttcctattgt attttgtttt aaactgcaat     8700

caatttgagg aacttttagg tgacgttgat tttgaaggag aaatggttaa cattgaaaac     8760

aagaacacca ttcctaaaat tttgttagag tggttgagtt cggataacga aaatgcaaac     8820

attaccctct atcaaggtgc gatactgttc aaatgttcag ttacggatga accaagtaaa     8880

tttaggtttg cgttgattat taggcatcta ttgacaaaga aacccatttg tgcattgcgt     8940

ttttacagtg ttattcgtaa cgaaataaga aaaatatcag catttgagca aaattcggat     9000

tgtgttccac ttgctttcga tattttaaac ttattagtga cgcattcaga gtctaattcg     9060

ttagaaaaac ttcacgaaga atccattgaa cgtctaacca aaagaggttt atcgattgtg     9120

acttcttctg gtatatttgc gaagaattcc gacatgatga tacctttaga tgtaaaacct     9180

gaagatatct atgaacgtaa gagaataatg acaatgattt tatcaaggat gtcatgttct     9240

gcttag                                                                9246


<210>  7
<211>  9248
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  7
atgtcccagc ccactaagaa taagaagaaa gaacacggga ccgattccaa gtcatcccgc       60

atgactcgga cgttggttaa tcatattctt tttgaaagaa ttctcccgat ccttccggtg      120

gagtctaatc taagtaccta ttcggaagtg gaagagtatt cctcattcat ttcatgcaga      180

tctgtgctca ttaacgttac cgtttcccaa gatgcaaacg ctatggtgga aggcaccttg      240

gagttgatag aatcgcttct tcaagggcac gaaatcattt cagataagtg tagcagtgac      300

gttattgaat caatactgat tatactaaga ttgttaagtg atgcgctaga gtataattgg      360

caaaatcaag aaagccttca ttacaacgac atttcgactc acgtagaaca tgaccaagaa      420

cagaagtaca gaccaaagct taacagtatt ctgcccgact actcgtcgac tcattccaat      480

ggcaacaaac actttttcca ccagagcaaa cctcaggcac tgataccgga actggcatcg      540

aaattgcttg agagttgcgc gaagttgaag ttcaatacaa gaactttgca aattttacaa      600

aatatgatca gtcatgttca tggaaacatt ctaacgactt tgagttcctc gattcttccc      660

cgccacaaat cctatctgac aaggcacaac catccttctc attgtaaaat gattgactct      720

actctaggcc atattctccg atttgtagcg gcttccaatc cgtccgagta ttttgaattt      780

atcagaaaga gtgtgcaagt gcccgtaaca cagacacaca cacacacacg cattcacact      840

cccattcaca ctctttgcca tcttccgttt ataacagcat agtgccccac tttgatcttt      900

tcagcttcat ctatttaagc aagcataatt ttaagaaata cttggaactc atcaaaaact      960

tatcggtgac gttaaggaaa acgatttatc attgcctact tttgcattac agcgccaaag     1020

caataatgtt ttggataatg gctaggcctg cggaatatta tgaactcttc aacttattaa     1080

aagataataa caatgaacac tcgaaatcct taaacacgtt aaaccataca cttttcgagg     1140

agatccattc gacttttaat gtgaatagca tgataaccac caatcaaaat gctcatcaag     1200

gctcatcttc cccttcgtcc tcctcgccat cgtcaccacc tagctcatca tcatcggata     1260

acaacaatca aaacataata gcaaaatcct taagtcgtca gctttctcac caccagtcat     1320

acattcaaca gcagtctgaa agaaaactac attcttcatg gactacaaac tctcaatcct     1380

ctacttcact gtcatcttca acgtctaatt caacaacaac tgatttctct actcacactc     1440

aaccaggaga atacgaccct tccttaccag atactcccac gatgtctaac atcactatta     1500

gtgcatcttc attattatct caaactccaa ctccaacaac acaattgcaa cagcggttga     1560

actcagcagc tgcagccgcc gccgcagctg cttcaccatc gaattccacc ccaactggat     1620

acacagcaga gcaacaaagt cgcgcttcat acgatgcaca caaaactggc catactggta     1680

aggattatga cgaacatttt ttgtctgtca ctcgtttgga taatgttttg gagttataca     1740

cgcactttga tgatactgag gtactaccac acacatccgt actgaagttt ttaactactt     1800

tgacaatgtt cgatattgac ctttttaatg aattaaacgc tacatcattc aaatatattc     1860

ctgattgtac tatgcatcgt ccaaaagaaa gaacaagttc tttcaataat actgcacacg     1920

agacaggttc cgaaaagact tcgggtataa aacatattac acaaggctta aagaaattaa     1980

cttctttacc ttcctcaacc aaaaaaactg taaaatttat gaagatgttg ctaagaaatt     2040

taaatgggaa tcaagctgta tcagatgttg ccctcttaga tacaatgagg gccttactat     2100

cattctttac aatgacttct gcggtctttc tcgtggatag aaacttaccc tcagtacttt     2160

ttgccaagag actcatcccc ataatgggga caaatttaag cgtcggtcaa gactggaatt     2220

caaaaataaa taacagtttg atggtttgtt tgaaaaaaaa ctccaccacg tttgttcaat     2280

tacaattaat attcttctct tcagctattc aattcgatca tgaattatta ctggcacgtc     2340

tgagcatcga tacaatggcc aacaatttaa acatgcagaa gctatgcctt tatactgaag     2400

gattcaggat attcttcgac ataccaagta agaaggaatt gcggaaggca attgcggtta     2460

aaatttctaa atttttcaaa acattattct ccattatagc agatattctt ttacaagaat     2520

ttccgtattt tgatgagcaa atcaccgaca tagttgcttc cattcttgac ggtacaatta     2580

tcaatgagta tggtacgaag aaacatttca aggggagctc accctcttta tgttcgacaa     2640

cccggtcaag atcaggatct acatctcaaa gttcaatgac accagtttct ccgctgggac     2700

tggatactga tatacgtcca atgaacaccc tgtctttagt tggttcaagt acttcaagaa     2760

attctgacaa cgttaattca ttaaacagtt caccaaagaa cttgtcttct gatccatact     2820

tgtcacatct tgtggcccca agagcacgtc atgctttagg tgggccatct agtattataa     2880

ggaataaaat accgactaca ttgacttcac ctccaggaac ggaaaaatct tcaccagtac     2940

aacgtccgca aacggaaagc atcagtgcca caccaatggc cataacaaat tctactccat     3000

tatcgtcggc agcattcgga attcgatcgc ctttgcagaa aataagaacg aggcgttatt     3060

ccgatgaaag tttaggaaaa ttcatgaaat caacaaataa ttacattcaa gaacatttga     3120

taccaaaaga tttgaatgaa gcaactcttc aagatgctag aagaataatg attaatattt     3180

tcagtatttt taagagaccg aatagttact tcatcattcc tcacaatata aattcgaatt     3240

tacaatgggt ttcgcaggat tttagaaata ttatgaaacc gattttcgtc gccatcgtaa     3300

gtccggatgt agatttacag aatactgctc aatcattcat ggatacctta ttatcgaatg     3360

ttattactta tggtgaatca gatgagaata tcagtattga agggtatcat cttctttgca     3420

gttacactgt aacattattt gcaatgggcc ttttcgattt gaaaattaat aatgaaaagc     3480

gtcaaattct cttggatata actgtcaagt ttatgaaggt tagatcacat ttagcaggga     3540

tcgcggaggc ctcacaccac atggaataca taagtgattc tgaaaaactc acctttccgc     3600

tgattatggg gactgttggt agggccctat ttgtttcatt atactctagt caacaaaaaa     3660

ttgaaaagac tttaaatatt gcttacacag agtatctttc tgcaatcaat tttcatgaga     3720

ggaatattga tgatgctgat aaaacttggg ttcataatat tgagtttgta gaagcgatgt     3780

gtcatgacaa ctacacaact tctggttcaa ttgctttcca aaggaggaca agaaataata     3840

ttttacgatt tgctactatt cctaacgcta tcttacttga ttctatgagg atgatctata     3900

agaagtggca tacttacaca cacagtaaaa gtttagaaaa acaagaacgg aacgacttca     3960

gaaatttcgc gggtatttta gcctctttgt cgggtatcct attcatcaat aaaaagatat     4020

tgcaagaaat gtatccatac ctactcgaca ccgtttcaga attgaaaaaa aatatagact     4080

cttttatctc aaaacaatgc caatggttaa actatccgga tttattaacg agagaaaatt     4140

caagagatat tctaagtgta gaactgcatc ctttgtcttt taacttactt tttaataatt     4200

tgaggctcaa gttaaaagaa cttgcttgtt cagacttatc aataccagaa aatgaaagtt     4260

cctatgtttt attagaacaa ataatcaaaa tgctgcggac aatcctaggt cgtgatgatg     4320

acaattatgt aatgatgctt ttttccacag agattgtaga tcttattgat ttattgacag     4380

atgaaataaa aaaaatacca gcctattgtc caaaatatct caaggcaatt attcaaatga     4440

ccaaaatgtt cagtgccttg cagcactcag aggttaattt aggtgtcaaa aatcattttc     4500

acgttaaaaa taaatggttg aggcaaatca ctgattggtt tcaagtgagt attgcgagag     4560

agtacgattt cgaaaacttg tcaaaacctc taaaagaaat ggatttggta aaaagagaca     4620

tggatattct atacatagat acggcaatcg aagcttcaac cgctattgcg tacctcacga     4680

gacatacttt cttagagatt ccacctgccg cgtcagatcc cgaactatct cgatctaggt     4740

ctgtgatatt tgggttttat ttcaacatct taatgaaagg ccttgaaaaa agtagtgatc     4800

gtgacaatta cccagtattc ttgaggcaca aaatgagtgt cctcaacgac aatgtaatac     4860

tttcattaac aaatctttca aacaccaatg ttgatgcgag tttgcagttc accttaccga     4920

tgggctattc gggaaatcga aacattagga atgcattttt ggaggtcttc attaatatcg     4980

ttacgaacta tcggacatac acggctaaaa ctgaccttgg aaaattagag gcagcagaca     5040

aatttttgcg atatacgatt gaacatcccc agctatcgtc ctttggagca gcggtttgtc     5100

ccgctagcga tattgatgct tatgctgctg gcttaataaa tgcatttgaa acgaggaatg     5160

ccacccacat tgtagtggca cagttgatta aaaatgaaat tgaaaaatct tccagaccta     5220

cggatatcct tagaagaaat agctgtgcta cgagatcatt atctatgcta gccaggtcca     5280

agggtaacga atatttgatt cgcactttgc aaccattact aaaaaaaatt atccagaaca     5340

gagatttttt tgaaattgag aaactaaaac cggaagattc agatgctgaa cgtcaaatag     5400

agctcttcgt taaatacatg aatgaattat tggaatccat atccaactcc gtatcttatt     5460

ttccccctcc tttattttat atttgccaaa acatttataa agttgcgtgt gaaaaatttc     5520

cggatcacgc aattatcgcc gctgggtctt tcgtgttttt acggtttttt tgtcctgctt     5580

tagtcagccc tgattctgaa aatatcatag atatttctca cttgagcgaa aagcgtacct     5640

tcatcagctt ggctaaagtt atccaaaata ttgccaatgg ctcagaaaat ttctccagat     5700

ggccagcttt gtgttcccaa aaggattttc ttaaagaatg tagcgataga attttcagat     5760

tcctagctga actttgtaga acagatcgca cgatagacat ccaagtgaga acagacccaa     5820

cgccaattgc atttgactat caattccttc attcctttgt ttacctttac ggtcttgagg     5880

tgagaaggaa tgtgctaaat gaagcaaaac atgatgatgg tgacattgat ggtgacgatt     5940

tctataagac cacattttta cttattgatg atgttcttgg ccaattaggc caacctaaaa     6000

tggaattttc caatgaaata ccaatataca taagagaaca tatggacgac tatccggaac     6060

tgtatgagtt catgaatagg cacgcgttca gaaacattga gacttcaaca gcgtacagcc     6120

caagcgttca cgagtccacc tcaagtgaag gcattccaat tattacgtta acaatgtcaa     6180

atttctcaga cagacatgtg gacattgata cagttgctta caagttcttg caaatttatg     6240

ctcgaatctg gaccaccaaa cactgtttaa taatcgactg tacagaattt gacgagggag     6300

ggcttgatat gaggaaattt atttctttgg ttatgggact attaccagaa gttgcaccca     6360

aaaattgtat aggctgttac tactttaacg taaacgagac atttatggat aattatggaa     6420

aatgtttgga caaagacaac gtatatgttt cctcgaaaat tcctcattat ttcattaata     6480

gtaactctga tgaaggactt atgaaatctg tgggtataac tggacaaggg ttgaaggttc     6540

tgcaagatat tcgtgtctct ctgcatgata tcacgcttta tgacgaaaaa agaaatagat     6600

ttacgccggt atcgttgaaa ataggcgata tttactttca agtcttgcat gaaactccta     6660

ggcaatataa aataagagac atgggtactt tattcgacgt aaaattcaat gatgtctacg     6720

aaattagccg aatatttgaa gtacatgttt cgtcaataac tggagtggca gctgaattta     6780

cagtaacttt tcaggacgag agaaggttga tttttagtag tccgaaatac cttgaaattg     6840

tgaagatgtt ctattacgca cagatccggt tagaaagtga atatgaaatg gataataatt     6900

cgagtacctc ctccccaaat tcaaacaaca aggacaaaca gcagaaagag agaacaaaat     6960

tattgtgcca cctactgtta gtatctctta ttggtctgtt tgatgagagt aaaaaaatga     7020

aaaacagttc gtataaccta atagctgcca ctgaggcgtc atttggcttg aactttggct     7080

cccattttca tcgctctccc gaggtgtacg tccccgaata tactacaaca tttttaggtg     7140

ttattggaaa gtctcttgca gagtctaatc cagaactcac agcctatatg tttatctatg     7200

ttttggaggc attgaagaac aacgtaattc ctcacgttta catccctcat accatttgcg     7260

gtttgtctta ttggatccct aatttatacc aacatgtgta tttggctgat gatgaagaag     7320

gccccgaaaa catatctcac attttccgaa ttcttatcag gctctctgtg agagagactg     7380

actttaaagc cgtatacatg caatatgttt ggttgctact tttagatgat ggccgcttaa     7440

ctgacattat cgttgatgaa gttattaatc atgcgttaga aagagactcc gaaaaccgcg     7500

attggaagaa aacaatatcg ttactgactg tcctacccac tactgaggtt gctaataaca     7560

ttattcaaaa aatattggca aaaattagat catttttacc gtcattgaag ttagaagcta     7620

tgacccaaag ttggtctgaa ctaacaatat tagttaagat aagcatccac gttttttttg     7680

aaacttcttt gctggtacag atgtacttac cagagatcct gtttatcgta tccttattaa     7740

ttgatgttgg tccaagggaa ctcagatcat cactacacca gctattaatg aatgtatgcc     7800

attccttggc tattgactca gctttatcac aagatcatag aaataatcta gatgaaataa     7860

gtgatatatt tgcacatcaa aaggtgaagt ttatgtttgg gttcagcgag gacaaaggac     7920

gaattttaca gatttttagc gcttcttctt ttgcaagcaa gtttaatatt ctggatttct     7980

tcatcaataa tatattattg ctgatggaat attcttcaac gtacgaagca aacgtgtgga     8040

agacaagata caagaaatat gtcttggaat ctgtgtttac aagtaattct tttctttcgg     8100

cacgttcaat catgattgtt ggtataatgg gtaaatctta cataactgaa gggttatgca     8160

aggctatgtt aattgaaacc atgaaagtta tcgccgaacc aaagattact gacgagcatc     8220

ttttcttagc catatctcat atttttactt attccaaaat tgttgaaggt ttggatccca     8280

accttgactt aatgaagcac ttattttggt tttcaacact cttccttgaa tcacgtcacc     8340

cgataatttt tgagggtgcc cttctctttg tgtcaaactg tataaggcgc ctatacatgg     8400

cccagtttga aaatgaaagc gaaacatcat tgataagtac tttacttaag gggagaaagt     8460

ttgctcatac ctttttaagc aagatagaga atcttagtgg tattgtttgg aatgaagata     8520

attttacaca cattctgatt ttcatcatta ataaaggact atccaatcct ttcattaaga     8580

gtacggcttt tgatttcttg aagatgatgt ttagaaactc ctactttgag catcaaatca     8640

atcagaaatc tgatcattat ttgtgctata tgttcctatt gtattttgtt ttaaactgca     8700

atcaatttga ggaactttta ggtgacgttg attttgaagg agaaatggtt aacattgaaa     8760

acaagaacac cattcctaaa attttgttag agtggttgag ttcggataac gaaaatgcaa     8820

acattaccct ctatcaaggt gcgatactgt tcaaatgttc agttacggat gaaccaagta     8880

aatttaggtt tgcgttgatt attaggcatc tattgacaaa gaaacccatt tgtgcattgc     8940

gtttttacag tgttattcgt aacgaaataa gaaaaatatc agcatttgag caaaattcgg     9000

attgtgttcc acttgctttc gatattttaa acttattagt gacgcattca gagtctaatt     9060

cgttagaaaa acttcacgaa gaatccattg aacgtctaac caaaagaggt ttatcgattg     9120

tgacttcttc tggtatattt gcgaagaatt ccgacatgat gataccttta gatgtaaaac     9180

ctgaagatat ctatgaacgt aagagaataa tgacaatgat tttatcaagg atgtcatgtt     9240

ctgcttag                                                              9248


<210>  8
<211>  3081
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  8

Met Ser Gln Pro Thr Lys Asn Lys Lys Lys Glu His Gly Thr Asp Ser 
1               5                   10                  15      


Lys Ser Ser Arg Met Thr Arg Thr Leu Val Asn His Ile Leu Phe Glu 
            20                  25                  30          


Arg Ile Leu Pro Ile Leu Pro Val Glu Ser Asn Leu Ser Thr Tyr Ser 
        35                  40                  45              


Glu Val Glu Glu Tyr Ser Ser Phe Ile Ser Cys Arg Ser Val Leu Ile 
    50                  55                  60                  


Asn Val Thr Val Ser Gln Asp Ala Asn Ala Met Val Glu Gly Thr Leu 
65                  70                  75                  80  


Glu Leu Ile Glu Ser Leu Leu Gln Gly His Glu Ile Ile Ser Asp Lys 
                85                  90                  95      


Cys Ser Ser Asp Val Ile Glu Ser Ile Leu Ile Ile Leu Arg Leu Leu 
            100                 105                 110         


Ser Asp Ala Leu Glu Tyr Asn Trp Gln Asn Gln Glu Ser Leu His Tyr 
        115                 120                 125             


Asn Asp Ile Ser Thr His Val Glu His Asp Gln Glu Gln Lys Tyr Arg 
    130                 135                 140                 


Pro Lys Leu Asn Ser Ile Leu Pro Asp Tyr Ser Ser Thr His Ser Asn 
145                 150                 155                 160 


Gly Asn Lys His Phe Phe His Gln Ser Lys Pro Gln Ala Leu Ile Pro 
                165                 170                 175     


Glu Leu Ala Ser Lys Leu Leu Glu Ser Cys Ala Lys Leu Lys Phe Asn 
            180                 185                 190         


Thr Arg Thr Leu Gln Ile Leu Gln Asn Met Ile Ser His Val His Gly 
        195                 200                 205             


Asn Ile Leu Thr Thr Leu Ser Ser Ser Ile Leu Pro Arg His Lys Ser 
    210                 215                 220                 


Tyr Leu Thr Arg His Asn His Pro Ser His Cys Lys Met Ile Asp Ser 
225                 230                 235                 240 


Thr Leu Gly His Ile Leu Arg Phe Val Ala Ala Ser Asn Pro Ser Glu 
                245                 250                 255     


Tyr Phe Glu Phe Ile Arg Lys Ser Val Gln Val Pro Val Thr Gln Thr 
            260                 265                 270         


His Thr His Thr His Ser His Ser His Ser His Ser Leu Pro Ser Ser 
        275                 280                 285             


Val Tyr Asn Ser Ile Val Pro His Phe Asp Leu Phe Ser Phe Ile Tyr 
    290                 295                 300                 


Leu Ser Lys His Asn Phe Lys Lys Tyr Leu Glu Leu Ile Lys Asn Leu 
305                 310                 315                 320 


Ser Val Thr Leu Arg Lys Thr Ile Tyr His Cys Leu Leu Leu His Tyr 
                325                 330                 335     


Ser Ala Lys Ala Ile Met Phe Trp Ile Met Ala Arg Pro Ala Glu Tyr 
            340                 345                 350         


Tyr Glu Leu Phe Asn Leu Leu Lys Asp Asn Asn Asn Glu His Ser Lys 
        355                 360                 365             


Ser Leu Asn Thr Leu Asn His Thr Leu Phe Glu Glu Ile His Ser Thr 
    370                 375                 380                 


Phe Asn Val Asn Ser Met Ile Thr Thr Asn Gln Asn Ala His Gln Gly 
385                 390                 395                 400 


Ser Ser Ser Pro Ser Ser Ser Ser Pro Ser Ser Pro Pro Ser Ser Ser 
                405                 410                 415     


Ser Ser Asp Asn Asn Asn Gln Asn Ile Ile Ala Lys Ser Leu Ser Arg 
            420                 425                 430         


Gln Leu Ser His His Gln Ser Tyr Ile Gln Gln Gln Ser Glu Arg Lys 
        435                 440                 445             


Leu His Ser Ser Trp Thr Thr Asn Ser Gln Ser Ser Thr Ser Leu Ser 
    450                 455                 460                 


Ser Ser Thr Ser Asn Ser Thr Thr Thr Asp Phe Ser Thr His Thr Gln 
465                 470                 475                 480 


Pro Gly Glu Tyr Asp Pro Ser Leu Pro Asp Thr Pro Thr Met Ser Asn 
                485                 490                 495     


Ile Thr Ile Ser Ala Ser Ser Leu Leu Ser Gln Thr Pro Thr Pro Thr 
            500                 505                 510         


Thr Gln Leu Gln Gln Arg Leu Asn Ser Ala Ala Ala Ala Ala Ala Ala 
        515                 520                 525             


Ala Ala Ser Pro Ser Asn Ser Thr Pro Thr Gly Tyr Thr Ala Glu Gln 
    530                 535                 540                 


Gln Ser Arg Ala Ser Tyr Asp Ala His Lys Thr Gly His Thr Gly Lys 
545                 550                 555                 560 


Asp Tyr Asp Glu His Phe Leu Ser Val Thr Arg Leu Asp Asn Val Leu 
                565                 570                 575     


Glu Leu Tyr Thr His Phe Asp Asp Thr Glu Val Leu Pro His Thr Ser 
            580                 585                 590         


Val Leu Lys Phe Leu Thr Thr Leu Thr Met Phe Asp Ile Asp Leu Phe 
        595                 600                 605             


Asn Glu Leu Asn Ala Thr Ser Phe Lys Tyr Ile Pro Asp Cys Thr Met 
    610                 615                 620                 


His Arg Pro Lys Glu Arg Thr Ser Ser Phe Asn Asn Thr Ala His Glu 
625                 630                 635                 640 


Thr Gly Ser Glu Lys Thr Ser Gly Ile Lys His Ile Thr Gln Gly Leu 
                645                 650                 655     


Lys Lys Leu Thr Ser Leu Pro Ser Ser Thr Lys Lys Thr Val Lys Phe 
            660                 665                 670         


Met Lys Met Leu Leu Arg Asn Leu Asn Gly Asn Gln Ala Val Ser Asp 
        675                 680                 685             


Val Ala Leu Leu Asp Thr Met Arg Ala Leu Leu Ser Phe Phe Thr Met 
    690                 695                 700                 


Thr Ser Ala Val Phe Leu Val Asp Arg Asn Leu Pro Ser Val Leu Phe 
705                 710                 715                 720 


Ala Lys Arg Leu Ile Pro Ile Met Gly Thr Asn Leu Ser Val Gly Gln 
                725                 730                 735     


Asp Trp Asn Ser Lys Ile Asn Asn Ser Leu Met Val Cys Leu Lys Lys 
            740                 745                 750         


Asn Ser Thr Thr Phe Val Gln Leu Gln Leu Ile Phe Phe Ser Ser Ala 
        755                 760                 765             


Ile Gln Phe Asp His Glu Leu Leu Leu Ala Arg Leu Ser Ile Asp Thr 
    770                 775                 780                 


Met Ala Asn Asn Leu Asn Met Gln Lys Leu Cys Leu Tyr Thr Glu Gly 
785                 790                 795                 800 


Phe Arg Ile Phe Phe Asp Ile Pro Ser Lys Lys Glu Leu Arg Lys Ala 
                805                 810                 815     


Ile Ala Val Lys Ile Ser Lys Phe Phe Lys Thr Leu Phe Ser Ile Ile 
            820                 825                 830         


Ala Asp Ile Leu Leu Gln Glu Phe Pro Tyr Phe Asp Glu Gln Ile Thr 
        835                 840                 845             


Asp Ile Val Ala Ser Ile Leu Asp Gly Thr Ile Ile Asn Glu Tyr Gly 
    850                 855                 860                 


Thr Lys Lys His Phe Lys Gly Ser Ser Pro Ser Leu Cys Ser Thr Thr 
865                 870                 875                 880 


Arg Ser Arg Ser Gly Ser Thr Ser Gln Ser Ser Met Thr Pro Val Ser 
                885                 890                 895     


Pro Leu Gly Leu Asp Thr Asp Ile Arg Pro Met Asn Thr Leu Ser Leu 
            900                 905                 910         


Val Gly Ser Ser Thr Ser Arg Asn Ser Asp Asn Val Asn Ser Leu Asn 
        915                 920                 925             


Ser Ser Pro Lys Asn Leu Ser Ser Asp Pro Tyr Leu Ser His Leu Val 
    930                 935                 940                 


Ala Pro Arg Ala Arg His Ala Leu Gly Gly Pro Ser Ser Ile Ile Arg 
945                 950                 955                 960 


Asn Lys Ile Pro Thr Thr Leu Thr Ser Pro Pro Gly Thr Glu Lys Ser 
                965                 970                 975     


Ser Pro Val Gln Arg Pro Gln Thr Glu Ser Ile Ser Ala Thr Pro Met 
            980                 985                 990         


Ala Ile Thr Asn Ser Thr Pro Leu  Ser Ser Ala Ala Phe  Gly Ile Arg 
        995                 1000                 1005             


Ser Pro  Leu Gln Lys Ile Arg  Thr Arg Arg Tyr Ser  Asp Glu Ser 
    1010                 1015                 1020             


Leu Gly  Lys Phe Met Lys Ser  Thr Asn Asn Tyr Ile  Gln Glu His 
    1025                 1030                 1035             


Leu Ile  Pro Lys Asp Leu Asn  Glu Ala Thr Leu Gln  Asp Ala Arg 
    1040                 1045                 1050             


Arg Ile  Met Ile Asn Ile Phe  Ser Ile Phe Lys Arg  Pro Asn Ser 
    1055                 1060                 1065             


Tyr Phe  Ile Ile Pro His Asn  Ile Asn Ser Asn Leu  Gln Trp Val 
    1070                 1075                 1080             


Ser Gln  Asp Phe Arg Asn Ile  Met Lys Pro Ile Phe  Val Ala Ile 
    1085                 1090                 1095             


Val Ser  Pro Asp Val Asp Leu  Gln Asn Thr Ala Gln  Ser Phe Met 
    1100                 1105                 1110             


Asp Thr  Leu Leu Ser Asn Val  Ile Thr Tyr Gly Glu  Ser Asp Glu 
    1115                 1120                 1125             


Asn Ile  Ser Ile Glu Gly Tyr  His Leu Leu Cys Ser  Tyr Thr Val 
    1130                 1135                 1140             


Thr Leu  Phe Ala Met Gly Leu  Phe Asp Leu Lys Ile  Asn Asn Glu 
    1145                 1150                 1155             


Lys Arg  Gln Ile Leu Leu Asp  Ile Thr Val Lys Phe  Met Lys Val 
    1160                 1165                 1170             


Arg Ser  His Leu Ala Gly Ile  Ala Glu Ala Ser His  His Met Glu 
    1175                 1180                 1185             


Tyr Ile  Ser Asp Ser Glu Lys  Leu Thr Phe Pro Leu  Ile Met Gly 
    1190                 1195                 1200             


Thr Val  Gly Arg Ala Leu Phe  Val Ser Leu Tyr Ser  Ser Gln Gln 
    1205                 1210                 1215             


Lys Ile  Glu Lys Thr Leu Asn  Ile Ala Tyr Thr Glu  Tyr Leu Ser 
    1220                 1225                 1230             


Ala Ile  Asn Phe His Glu Arg  Asn Ile Asp Asp Ala  Asp Lys Thr 
    1235                 1240                 1245             


Trp Val  His Asn Ile Glu Phe  Val Glu Ala Met Cys  His Asp Asn 
    1250                 1255                 1260             


Tyr Thr  Thr Ser Gly Ser Ile  Ala Phe Gln Arg Arg  Thr Arg Asn 
    1265                 1270                 1275             


Asn Ile  Leu Arg Phe Ala Thr  Ile Pro Asn Ala Ile  Leu Leu Asp 
    1280                 1285                 1290             


Ser Met  Arg Met Ile Tyr Lys  Lys Trp His Thr Tyr  Thr His Ser 
    1295                 1300                 1305             


Lys Ser  Leu Glu Lys Gln Glu  Arg Asn Asp Phe Arg  Asn Phe Ala 
    1310                 1315                 1320             


Gly Ile  Leu Ala Ser Leu Ser  Gly Ile Leu Phe Ile  Asn Lys Lys 
    1325                 1330                 1335             


Ile Leu  Gln Glu Met Tyr Pro  Tyr Leu Leu Asp Thr  Val Ser Glu 
    1340                 1345                 1350             


Leu Lys  Lys Asn Ile Asp Ser  Phe Ile Ser Lys Gln  Cys Gln Trp 
    1355                 1360                 1365             


Leu Asn  Tyr Pro Asp Leu Leu  Thr Arg Glu Asn Ser  Arg Asp Ile 
    1370                 1375                 1380             


Leu Ser  Val Glu Leu His Pro  Leu Ser Phe Asn Leu  Leu Phe Asn 
    1385                 1390                 1395             


Asn Leu  Arg Leu Lys Leu Lys  Glu Leu Ala Cys Ser  Asp Leu Ser 
    1400                 1405                 1410             


Ile Pro  Glu Asn Glu Ser Ser  Tyr Val Leu Leu Glu  Gln Ile Ile 
    1415                 1420                 1425             


Lys Met  Leu Arg Thr Ile Leu  Gly Arg Asp Asp Asp  Asn Tyr Val 
    1430                 1435                 1440             


Met Met  Leu Phe Ser Thr Glu  Ile Val Asp Leu Ile  Asp Leu Leu 
    1445                 1450                 1455             


Thr Asp  Glu Ile Lys Lys Ile  Pro Ala Tyr Cys Pro  Lys Tyr Leu 
    1460                 1465                 1470             


Lys Ala  Ile Ile Gln Met Thr  Lys Met Phe Ser Ala  Leu Gln His 
    1475                 1480                 1485             


Ser Glu  Val Asn Leu Gly Val  Lys Asn His Phe His  Val Lys Asn 
    1490                 1495                 1500             


Lys Trp  Leu Arg Gln Ile Thr  Asp Trp Phe Gln Val  Ser Ile Ala 
    1505                 1510                 1515             


Arg Glu  Tyr Asp Phe Glu Asn  Leu Ser Lys Pro Leu  Lys Glu Met 
    1520                 1525                 1530             


Asp Leu  Val Lys Arg Asp Met  Asp Ile Leu Tyr Ile  Asp Thr Ala 
    1535                 1540                 1545             


Ile Glu  Ala Ser Thr Ala Ile  Ala Tyr Leu Thr Arg  His Thr Phe 
    1550                 1555                 1560             


Leu Glu  Ile Pro Pro Ala Ala  Ser Asp Pro Glu Leu  Ser Arg Ser 
    1565                 1570                 1575             


Arg Ser  Val Ile Phe Gly Phe  Tyr Phe Asn Ile Leu  Met Lys Gly 
    1580                 1585                 1590             


Leu Glu  Lys Ser Ser Asp Arg  Asp Asn Tyr Pro Val  Phe Leu Arg 
    1595                 1600                 1605             


His Lys  Met Ser Val Leu Asn  Asp Asn Val Ile Leu  Ser Leu Thr 
    1610                 1615                 1620             


Asn Leu  Ser Asn Thr Asn Val  Asp Ala Ser Leu Gln  Phe Thr Leu 
    1625                 1630                 1635             


Pro Met  Gly Tyr Ser Gly Asn  Arg Asn Ile Arg Asn  Ala Phe Leu 
    1640                 1645                 1650             


Glu Val  Phe Ile Asn Ile Val  Thr Asn Tyr Arg Thr  Tyr Thr Ala 
    1655                 1660                 1665             


Lys Thr  Asp Leu Gly Lys Leu  Glu Ala Ala Asp Lys  Phe Leu Arg 
    1670                 1675                 1680             


Tyr Thr  Ile Glu His Pro Gln  Leu Ser Ser Phe Gly  Ala Ala Val 
    1685                 1690                 1695             


Cys Pro  Ala Ser Asp Ile Asp  Ala Tyr Ala Ala Gly  Leu Ile Asn 
    1700                 1705                 1710             


Ala Phe  Glu Thr Arg Asn Ala  Thr His Ile Val Val  Ala Gln Leu 
    1715                 1720                 1725             


Ile Lys  Asn Glu Ile Glu Lys  Ser Ser Arg Pro Thr  Asp Ile Leu 
    1730                 1735                 1740             


Arg Arg  Asn Ser Cys Ala Thr  Arg Ser Leu Ser Met  Leu Ala Arg 
    1745                 1750                 1755             


Ser Lys  Gly Asn Glu Tyr Leu  Ile Arg Thr Leu Gln  Pro Leu Leu 
    1760                 1765                 1770             


Lys Lys  Ile Ile Gln Asn Arg  Asp Phe Phe Glu Ile  Glu Lys Leu 
    1775                 1780                 1785             


Lys Pro  Glu Asp Ser Asp Ala  Glu Arg Gln Ile Glu  Leu Phe Val 
    1790                 1795                 1800             


Lys Tyr  Met Asn Glu Leu Leu  Glu Ser Ile Ser Asn  Ser Val Ser 
    1805                 1810                 1815             


Tyr Phe  Pro Pro Pro Leu Phe  Tyr Ile Cys Gln Asn  Ile Tyr Lys 
    1820                 1825                 1830             


Val Ala  Cys Glu Lys Phe Pro  Asp His Ala Ile Ile  Ala Ala Gly 
    1835                 1840                 1845             


Ser Phe  Val Phe Leu Arg Phe  Phe Cys Pro Ala Leu  Val Ser Pro 
    1850                 1855                 1860             


Asp Ser  Glu Asn Ile Ile Asp  Ile Ser His Leu Ser  Glu Lys Arg 
    1865                 1870                 1875             


Thr Phe  Ile Ser Leu Ala Lys  Val Ile Gln Asn Ile  Ala Asn Gly 
    1880                 1885                 1890             


Ser Glu  Asn Phe Ser Arg Trp  Pro Ala Leu Cys Ser  Gln Lys Asp 
    1895                 1900                 1905             


Phe Leu  Lys Glu Cys Ser Asp  Arg Ile Phe Arg Phe  Leu Ala Glu 
    1910                 1915                 1920             


Leu Cys  Arg Thr Asp Arg Thr  Ile Asp Ile Gln Val  Arg Thr Asp 
    1925                 1930                 1935             


Pro Thr  Pro Ile Ala Phe Asp  Tyr Gln Phe Leu His  Ser Phe Val 
    1940                 1945                 1950             


Tyr Leu  Tyr Gly Leu Glu Val  Arg Arg Asn Val Leu  Asn Glu Ala 
    1955                 1960                 1965             


Lys His  Asp Asp Gly Asp Ile  Asp Gly Asp Asp Phe  Tyr Lys Thr 
    1970                 1975                 1980             


Thr Phe  Leu Leu Ile Asp Asp  Val Leu Gly Gln Leu  Gly Gln Pro 
    1985                 1990                 1995             


Lys Met  Glu Phe Ser Asn Glu  Ile Pro Ile Tyr Ile  Arg Glu His 
    2000                 2005                 2010             


Met Asp  Asp Tyr Pro Glu Leu  Tyr Glu Phe Met Asn  Arg His Ala 
    2015                 2020                 2025             


Phe Arg  Asn Ile Glu Thr Ser  Thr Ala Tyr Ser Pro  Ser Val His 
    2030                 2035                 2040             


Glu Ser  Thr Ser Ser Glu Gly  Ile Pro Ile Ile Thr  Leu Thr Met 
    2045                 2050                 2055             


Ser Asn  Phe Ser Asp Arg His  Val Asp Ile Asp Thr  Val Ala Tyr 
    2060                 2065                 2070             


Lys Phe  Leu Gln Ile Tyr Ala  Arg Ile Trp Thr Thr  Lys His Cys 
    2075                 2080                 2085             


Leu Ile  Ile Asp Cys Thr Glu  Phe Asp Glu Gly Gly  Leu Asp Met 
    2090                 2095                 2100             


Arg Lys  Phe Ile Ser Leu Val  Met Gly Leu Leu Pro  Glu Val Ala 
    2105                 2110                 2115             


Pro Lys  Asn Cys Ile Gly Cys  Tyr Tyr Phe Asn Val  Asn Glu Thr 
    2120                 2125                 2130             


Phe Met  Asp Asn Tyr Gly Lys  Cys Leu Asp Lys Asp  Asn Val Tyr 
    2135                 2140                 2145             


Val Ser  Ser Lys Ile Pro His  Tyr Phe Ile Asn Ser  Asn Ser Asp 
    2150                 2155                 2160             


Glu Gly  Leu Met Lys Ser Val  Gly Ile Thr Gly Gln  Gly Leu Lys 
    2165                 2170                 2175             


Val Leu  Gln Asp Ile Arg Val  Ser Leu His Asp Ile  Thr Leu Tyr 
    2180                 2185                 2190             


Asp Glu  Lys Arg Asn Arg Phe  Thr Pro Val Ser Leu  Lys Ile Gly 
    2195                 2200                 2205             


Asp Ile  Tyr Phe Gln Val Leu  His Glu Thr Pro Arg  Gln Tyr Lys 
    2210                 2215                 2220             


Ile Arg  Asp Met Gly Thr Leu  Phe Asp Val Lys Phe  Asn Asp Val 
    2225                 2230                 2235             


Tyr Glu  Ile Ser Arg Ile Phe  Glu Val His Val Ser  Ser Ile Thr 
    2240                 2245                 2250             


Gly Val  Ala Ala Glu Phe Thr  Val Thr Phe Gln Asp  Glu Arg Arg 
    2255                 2260                 2265             


Leu Ile  Phe Ser Ser Pro Lys  Tyr Leu Glu Ile Val  Lys Met Phe 
    2270                 2275                 2280             


Tyr Tyr  Ala Gln Ile Arg Leu  Glu Ser Glu Tyr Glu  Met Asp Asn 
    2285                 2290                 2295             


Asn Ser  Ser Thr Ser Ser Pro  Asn Ser Asn Asn Lys  Asp Lys Gln 
    2300                 2305                 2310             


Gln Lys  Glu Arg Thr Lys Leu  Leu Cys His Leu Leu  Leu Val Ser 
    2315                 2320                 2325             


Leu Ile  Gly Leu Phe Asp Glu  Ser Lys Lys Met Lys  Asn Ser Ser 
    2330                 2335                 2340             


Tyr Asn  Leu Ile Ala Ala Thr  Glu Ala Ser Phe Gly  Leu Asn Phe 
    2345                 2350                 2355             


Gly Ser  His Phe His Arg Ser  Pro Glu Val Tyr Val  Pro Glu Tyr 
    2360                 2365                 2370             


Thr Thr  Thr Phe Leu Gly Val  Ile Gly Lys Ser Leu  Ala Glu Ser 
    2375                 2380                 2385             


Asn Pro  Glu Leu Thr Ala Tyr  Met Phe Ile Tyr Val  Leu Glu Ala 
    2390                 2395                 2400             


Leu Lys  Asn Asn Val Ile Pro  His Val Tyr Ile Pro  His Thr Ile 
    2405                 2410                 2415             


Cys Gly  Leu Ser Tyr Trp Ile  Pro Asn Leu Tyr Gln  His Val Tyr 
    2420                 2425                 2430             


Leu Ala  Asp Asp Glu Glu Gly  Pro Glu Asn Ile Ser  His Ile Phe 
    2435                 2440                 2445             


Arg Ile  Leu Ile Arg Leu Ser  Val Arg Glu Thr Asp  Phe Lys Ala 
    2450                 2455                 2460             


Val Tyr  Met Gln Tyr Val Trp  Leu Leu Leu Leu Asp  Asp Gly Arg 
    2465                 2470                 2475             


Leu Thr  Asp Ile Ile Val Asp  Glu Val Ile Asn His  Ala Leu Glu 
    2480                 2485                 2490             


Arg Asp  Ser Glu Asn Arg Asp  Trp Lys Lys Thr Ile  Ser Leu Leu 
    2495                 2500                 2505             


Thr Val  Leu Pro Thr Thr Glu  Val Ala Asn Asn Ile  Ile Gln Lys 
    2510                 2515                 2520             


Ile Leu  Ala Lys Ile Arg Ser  Phe Leu Pro Ser Leu  Lys Leu Glu 
    2525                 2530                 2535             


Ala Met  Thr Gln Ser Trp Ser  Glu Leu Thr Ile Leu  Val Lys Ile 
    2540                 2545                 2550             


Ser Ile  His Val Phe Phe Glu  Thr Ser Leu Leu Val  Gln Met Tyr 
    2555                 2560                 2565             


Leu Pro  Glu Ile Leu Phe Ile  Val Ser Leu Leu Ile  Asp Val Gly 
    2570                 2575                 2580             


Pro Arg  Glu Leu Arg Ser Ser  Leu His Gln Leu Leu  Met Asn Val 
    2585                 2590                 2595             


Cys His  Ser Leu Ala Ile Asp  Ser Ala Leu Ser Gln  Asp His Arg 
    2600                 2605                 2610             


Asn Asn  Leu Asp Glu Ile Ser  Asp Ile Phe Ala His  Gln Lys Val 
    2615                 2620                 2625             


Lys Phe  Met Phe Gly Phe Ser  Glu Asp Lys Gly Arg  Ile Leu Gln 
    2630                 2635                 2640             


Ile Phe  Ser Ala Ser Ser Phe  Ala Ser Lys Phe Asn  Ile Leu Asp 
    2645                 2650                 2655             


Phe Phe  Ile Asn Asn Ile Leu  Leu Leu Met Glu Tyr  Ser Ser Thr 
    2660                 2665                 2670             


Tyr Glu  Ala Asn Val Trp Lys  Thr Arg Tyr Lys Lys  Tyr Val Leu 
    2675                 2680                 2685             


Glu Ser  Val Phe Thr Ser Asn  Ser Phe Leu Ser Ala  Arg Ser Ile 
    2690                 2695                 2700             


Met Ile  Val Gly Ile Met Gly  Lys Ser Tyr Ile Thr  Glu Gly Leu 
    2705                 2710                 2715             


Cys Lys  Ala Met Leu Ile Glu  Thr Met Lys Val Ile  Ala Glu Pro 
    2720                 2725                 2730             


Lys Ile  Thr Asp Glu His Leu  Phe Leu Ala Ile Ser  His Ile Phe 
    2735                 2740                 2745             


Thr Tyr  Ser Lys Ile Val Glu  Gly Leu Asp Pro Asn  Leu Asp Leu 
    2750                 2755                 2760             


Met Lys  His Leu Phe Trp Phe  Ser Thr Leu Phe Leu  Glu Ser Arg 
    2765                 2770                 2775             


His Pro  Ile Ile Phe Glu Gly  Ala Leu Leu Phe Val  Ser Asn Cys 
    2780                 2785                 2790             


Ile Arg  Arg Leu Tyr Met Ala  Gln Phe Glu Asn Glu  Ser Glu Thr 
    2795                 2800                 2805             


Ser Leu  Ile Ser Thr Leu Leu  Lys Gly Arg Lys Phe  Ala His Thr 
    2810                 2815                 2820             


Phe Leu  Ser Lys Ile Glu Asn  Leu Ser Gly Ile Val  Trp Asn Glu 
    2825                 2830                 2835             


Asp Asn  Phe Thr His Ile Leu  Ile Phe Ile Ile Asn  Lys Gly Leu 
    2840                 2845                 2850             


Ser Asn  Pro Phe Ile Lys Ser  Thr Ala Phe Asp Phe  Leu Lys Met 
    2855                 2860                 2865             


Met Phe  Arg Asn Ser Tyr Phe  Glu His Gln Ile Asn  Gln Lys Ser 
    2870                 2875                 2880             


Asp His  Tyr Leu Cys Tyr Met  Phe Leu Leu Tyr Phe  Val Leu Asn 
    2885                 2890                 2895             


Cys Asn  Gln Phe Glu Glu Leu  Leu Gly Asp Val Asp  Phe Glu Gly 
    2900                 2905                 2910             


Glu Met  Val Asn Ile Glu Asn  Lys Asn Thr Ile Pro  Lys Ile Leu 
    2915                 2920                 2925             


Leu Glu  Trp Leu Ser Ser Asp  Asn Glu Asn Ala Asn  Ile Thr Leu 
    2930                 2935                 2940             


Tyr Gln  Gly Ala Ile Leu Phe  Lys Cys Ser Val Thr  Asp Glu Pro 
    2945                 2950                 2955             


Ser Lys  Phe Arg Phe Ala Leu  Ile Ile Arg His Leu  Leu Thr Lys 
    2960                 2965                 2970             


Lys Pro  Ile Cys Ala Leu Arg  Phe Tyr Ser Val Ile  Arg Asn Glu 
    2975                 2980                 2985             


Ile Arg  Lys Ile Ser Ala Phe  Glu Gln Asn Ser Asp  Cys Val Pro 
    2990                 2995                 3000             


Leu Ala  Phe Asp Ile Leu Asn  Leu Leu Val Thr His  Ser Glu Ser 
    3005                 3010                 3015             


Asn Ser  Leu Glu Lys Leu His  Glu Glu Ser Ile Glu  Arg Leu Thr 
    3020                 3025                 3030             


Lys Arg  Gly Leu Ser Ile Val  Thr Ser Ser Gly Ile  Phe Ala Lys 
    3035                 3040                 3045             


Asn Ser  Asp Met Met Ile Pro  Leu Asp Val Lys Pro  Glu Asp Ile 
    3050                 3055                 3060             


Tyr Glu  Arg Lys Arg Ile Met  Thr Met Ile Leu Ser  Arg Met Ser 
    3065                 3070                 3075             


Cys Ser  Ala 
    3080     


<210>  9
<211>  293
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  9

Met Ser Gln Pro Thr Lys Asn Lys Lys Lys Glu His Gly Thr Asp Ser 
1               5                   10                  15      


Lys Ser Ser Arg Met Thr Arg Thr Leu Val Asn His Ile Leu Phe Glu 
            20                  25                  30          


Arg Ile Leu Pro Ile Leu Pro Val Glu Ser Asn Leu Ser Thr Tyr Ser 
        35                  40                  45              


Glu Val Glu Glu Tyr Ser Ser Phe Ile Ser Cys Arg Ser Val Leu Ile 
    50                  55                  60                  


Asn Val Thr Val Ser Gln Asp Ala Asn Ala Met Val Glu Gly Thr Leu 
65                  70                  75                  80  


Glu Leu Ile Glu Ser Leu Leu Gln Gly His Glu Ile Ile Ser Asp Lys 
                85                  90                  95      


Cys Ser Ser Asp Val Ile Glu Ser Ile Leu Ile Ile Leu Arg Leu Leu 
            100                 105                 110         


Ser Asp Ala Leu Glu Tyr Asn Trp Gln Asn Gln Glu Ser Leu His Tyr 
        115                 120                 125             


Asn Asp Ile Ser Thr His Val Glu His Asp Gln Glu Gln Lys Tyr Arg 
    130                 135                 140                 


Pro Lys Leu Asn Ser Ile Leu Pro Asp Tyr Ser Ser Thr His Ser Asn 
145                 150                 155                 160 


Gly Asn Lys His Phe Phe His Gln Ser Lys Pro Gln Ala Leu Ile Pro 
                165                 170                 175     


Glu Leu Ala Ser Lys Leu Leu Glu Ser Cys Ala Lys Leu Lys Phe Asn 
            180                 185                 190         


Thr Arg Thr Leu Gln Ile Leu Gln Asn Met Ile Ser His Val His Gly 
        195                 200                 205             


Asn Ile Leu Thr Thr Leu Ser Ser Ser Ile Leu Pro Arg His Lys Ser 
    210                 215                 220                 


Tyr Leu Thr Arg His Asn His Pro Ser His Cys Lys Met Ile Asp Ser 
225                 230                 235                 240 


Thr Leu Gly His Ile Leu Arg Phe Val Ala Ala Ser Asn Pro Ser Glu 
                245                 250                 255     


Tyr Phe Glu Phe Ile Arg Lys Ser Val Gln Val Pro Val Thr Gln Thr 
            260                 265                 270         


His Thr His Thr Arg Ile His Thr Pro Ile His Thr Leu Cys His Leu 
        275                 280                 285             


Pro Phe Ile Thr Ala 
    290             


<210>  10
<211>  309
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  10

Met Gln Gly Asn Lys Ser Thr Ile Arg Glu Tyr Lys Ile Val Val Val 
1               5                   10                  15      


Gly Gly Gly Gly Val Gly Lys Ser Ala Leu Thr Ile Gln Phe Ile Gln 
            20                  25                  30          


Ser Tyr Phe Val Asp Glu Tyr Asp Pro Thr Ile Glu Asp Ser Tyr Arg 
        35                  40                  45              


Lys Gln Val Val Ile Asp Asp Lys Val Ser Ile Leu Asp Ile Leu Asp 
    50                  55                  60                  


Thr Ala Gly Gln Glu Glu Tyr Ser Ala Met Arg Glu Gln Tyr Met Arg 
65                  70                  75                  80  


Thr Gly Glu Gly Phe Leu Leu Val Tyr Ser Val Thr Ser Arg Asn Ser 
                85                  90                  95      


Phe Asp Glu Leu Leu Ser Tyr Tyr Gln Gln Ile Gln Arg Val Lys Asp 
            100                 105                 110         


Ser Asp Tyr Ile Pro Val Val Val Val Gly Asn Lys Leu Asp Leu Glu 
        115                 120                 125             


Asn Glu Arg Gln Val Ser Tyr Glu Asp Gly Leu Arg Leu Ala Lys Gln 
    130                 135                 140                 


Leu Asn Ala Pro Phe Leu Glu Thr Ser Ala Lys Gln Ala Ile Asn Val 
145                 150                 155                 160 


Asp Glu Ala Phe Tyr Ser Leu Ile Arg Leu Val Arg Asp Asp Gly Gly 
                165                 170                 175     


Lys Tyr Asn Ser Met Asn Arg Gln Leu Asp Asn Thr Asn Glu Ile Arg 
            180                 185                 190         


Asp Ser Glu Leu Thr Ser Ser Ala Thr Ala Asp Arg Glu Lys Lys Asn 
        195                 200                 205             


Asn Gly Ser Tyr Val Leu Asp Asn Ser Leu Thr Asn Ala Gly Thr Gly 
    210                 215                 220                 


Ser Ser Ser Lys Ser Ala Val Asn His Asn Gly Glu Thr Thr Lys Arg 
225                 230                 235                 240 


Thr Asp Glu Lys Asn Tyr Val Asn Gln Asn Asn Asn Asn Glu Gly Asn 
                245                 250                 255     


Thr Lys Tyr Ser Ser Asn Gly Asn Gly Asn Arg Ser Asp Ile Ser Arg 
            260                 265                 270         


Gly Asn Gln Asn Asn Ala Leu Asn Ser Arg Ser Lys Gln Ser Ala Glu 
        275                 280                 285             


Pro Gln Lys Asn Ser Ser Ala Asn Ala Arg Lys Glu Ser Ser Gly Gly 
    290                 295                 300                 


Cys Cys Ile Ile Cys 
305                 


<210>  11
<211>  309
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  11

Met Gln Gly Asn Lys Ser Thr Ile Arg Glu Tyr Lys Ile Val Val Val 
1               5                   10                  15      


Gly Gly Gly Gly Val Gly Lys Ser Ala Leu Thr Ile Gln Phe Ile Gln 
            20                  25                  30          


Ser Tyr Phe Val Asp Glu Tyr Asp Pro Thr Ile Glu Asp Ser Tyr Arg 
        35                  40                  45              


Lys Gln Val Val Ile Asp Asp Lys Val Ser Ile Leu Asp Ile Leu Asp 
    50                  55                  60                  


Thr Thr Gly Gln Glu Glu Tyr Ser Ala Met Arg Glu Gln Tyr Met Arg 
65                  70                  75                  80  


Thr Gly Glu Gly Phe Leu Leu Val Tyr Ser Val Thr Ser Arg Asn Ser 
                85                  90                  95      


Phe Asp Glu Leu Leu Ser Tyr Tyr Gln Gln Ile Gln Arg Val Lys Asp 
            100                 105                 110         


Ser Asp Tyr Ile Pro Val Val Val Val Gly Asn Lys Leu Asp Leu Glu 
        115                 120                 125             


Asn Glu Arg Gln Val Ser Tyr Glu Asp Gly Leu Arg Leu Ala Lys Gln 
    130                 135                 140                 


Leu Asn Ala Pro Phe Leu Glu Thr Ser Ala Lys Gln Ala Ile Asn Val 
145                 150                 155                 160 


Asp Glu Ala Phe Tyr Ser Leu Ile Arg Leu Val Arg Asp Asp Gly Gly 
                165                 170                 175     


Lys Tyr Asn Ser Met Asn Arg Gln Leu Asp Asn Thr Asn Glu Ile Arg 
            180                 185                 190         


Asp Ser Glu Leu Thr Ser Ser Ala Thr Ala Asp Arg Glu Lys Lys Asn 
        195                 200                 205             


Asn Gly Ser Tyr Val Leu Asp Asn Ser Leu Thr Asn Ala Gly Thr Gly 
    210                 215                 220                 


Ser Ser Ser Lys Ser Ala Val Asn His Asn Gly Glu Thr Thr Lys Arg 
225                 230                 235                 240 


Thr Asp Glu Lys Asn Tyr Val Asn Gln Asn Asn Asn Asn Glu Gly Asn 
                245                 250                 255     


Thr Lys Tyr Ser Ser Asn Gly Asn Gly Asn Arg Ser Asp Ile Ser Arg 
            260                 265                 270         


Gly Asn Gln Asn Asn Ala Leu Asn Ser Arg Ser Lys Gln Ser Ala Glu 
        275                 280                 285             


Pro Gln Lys Asn Ser Ser Ala Asn Ala Arg Lys Glu Ser Ser Gly Gly 
    290                 295                 300                 


Cys Cys Ile Ile Cys 
305                 


