               SEQUENCE LISTING

<110> A1M Pharma AB, Medicon Village, 223 81 Lund, Sweden

<120> Novel alpha-1-microglobulin derived proteins and their use

<130> P017240PCT1

<160> 95

<170> BiSSAP 1.3

<210> 1
<211> 183
<212> PRT
<213> Homo sapiens

<220> 
<223> Wildtype human A1M, no mutations

<400> 1
Gly Pro Val Pro Thr Pro Pro Asp Asn Ile Gln Val Gln Glu Asn Phe 
1               5                   10                  15      
Asn Ile Ser Arg Ile Tyr Gly Lys Trp Tyr Asn Leu Ala Ile Gly Ser 
            20                  25                  30          
Thr Cys Pro Trp Leu Lys Lys Ile Met Asp Arg Met Thr Val Ser Thr 
        35                  40                  45              
Leu Val Leu Gly Glu Gly Ala Thr Glu Ala Glu Ile Ser Met Thr Ser 
    50                  55                  60                  
Thr Arg Trp Arg Lys Gly Val Cys Glu Glu Thr Ser Gly Ala Tyr Glu 
65                  70                  75                  80  
Lys Thr Asp Thr Asp Gly Lys Phe Leu Tyr His Lys Ser Lys Trp Asn 
                85                  90                  95      
Ile Thr Met Glu Ser Tyr Val Val His Thr Asn Tyr Asp Glu Tyr Ala 
            100                 105                 110         
Ile Phe Leu Thr Lys Lys Phe Ser Arg His His Gly Pro Thr Ile Thr 
        115                 120                 125             
Ala Lys Leu Tyr Gly Arg Ala Pro Gln Leu Arg Glu Thr Leu Leu Gln 
    130                 135                 140                 
Asp Phe Arg Val Val Ala Gln Gly Val Gly Ile Pro Glu Asp Ser Ile 
145                 150                 155                 160 
Phe Thr Met Ala Asp Arg Gly Glu Cys Val Pro Gly Glu Gln Glu Pro 
                165                 170                 175     
Glu Pro Ile Leu Ile Pro Arg 
            180             

<210> 2
<211> 184
<212> PRT
<213> Homo sapiens

<220> 
<223> rhA1M, ie N-terminal Met

<400> 2
Met Gly Pro Val Pro Thr Pro Pro Asp Asn Ile Gln Val Gln Glu Asn 
1               5                   10                  15      
Phe Asn Ile Ser Arg Ile Tyr Gly Lys Trp Tyr Asn Leu Ala Ile Gly 
            20                  25                  30          
Ser Thr Cys Pro Trp Leu Lys Lys Ile Met Asp Arg Met Thr Val Ser 
        35                  40                  45              
Thr Leu Val Leu Gly Glu Gly Ala Thr Glu Ala Glu Ile Ser Met Thr 
    50                  55                  60                  
Ser Thr Arg Trp Arg Lys Gly Val Cys Glu Glu Thr Ser Gly Ala Tyr 
65                  70                  75                  80  
Glu Lys Thr Asp Thr Asp Gly Lys Phe Leu Tyr His Lys Ser Lys Trp 
                85                  90                  95      
Asn Ile Thr Met Glu Ser Tyr Val Val His Thr Asn Tyr Asp Glu Tyr 
            100                 105                 110         
Ala Ile Phe Leu Thr Lys Lys Phe Ser Arg His His Gly Pro Thr Ile 
        115                 120                 125             
Thr Ala Lys Leu Tyr Gly Arg Ala Pro Gln Leu Arg Glu Thr Leu Leu 
    130                 135                 140                 
Gln Asp Phe Arg Val Val Ala Gln Gly Val Gly Ile Pro Glu Asp Ser 
145                 150                 155                 160 
Ile Phe Thr Met Ala Asp Arg Gly Glu Cys Val Pro Gly Glu Gln Glu 
                165                 170                 175     
Pro Glu Pro Ile Leu Ile Pro Arg 
            180                 

<210> 3
<211> 184
<212> PRT
<213> Homo sapiens

<220> 
<223> hA1M, No tag, N-terminal Met, N17,96D; R66H

<400> 3
Met Gly Pro Val Pro Thr Pro Pro Asp Asn Ile Gln Val Gln Glu Asn 
1               5                   10                  15      
Phe Asp Ile Ser Arg Ile Tyr Gly Lys Trp Tyr Asn Leu Ala Ile Gly 
            20                  25                  30          
Ser Thr Cys Pro Trp Leu Lys Lys Ile Met Asp Arg Met Thr Val Ser 
        35                  40                  45              
Thr Leu Val Leu Gly Glu Gly Ala Thr Glu Ala Glu Ile Ser Met Thr 
    50                  55                  60                  
Ser Thr His Trp Arg Lys Gly Val Cys Glu Glu Thr Ser Gly Ala Tyr 
65                  70                  75                  80  
Glu Lys Thr Asp Thr Asp Gly Lys Phe Leu Tyr His Lys Ser Lys Trp 
                85                  90                  95      
Asp Ile Thr Met Glu Ser Tyr Val Val His Thr Asn Tyr Asp Glu Tyr 
            100                 105                 110         
Ala Ile Phe Leu Thr Lys Lys Phe Ser Arg His His Gly Pro Thr Ile 
        115                 120                 125             
Thr Ala Lys Leu Tyr Gly Arg Ala Pro Gln Leu Arg Glu Thr Leu Leu 
    130                 135                 140                 
Gln Asp Phe Arg Val Val Ala Gln Gly Val Gly Ile Pro Glu Asp Ser 
145                 150                 155                 160 
Ile Phe Thr Met Ala Asp Arg Gly Glu Cys Val Pro Gly Glu Gln Glu 
                165                 170                 175     
Pro Glu Pro Ile Leu Ile Pro Arg 
            180                 

<210> 4
<211> 184
<212> PRT
<213> Homo sapiens

<220> 
<223> hA1M, not tag, N-terminal Met, M41K

<400> 4
Met Gly Pro Val Pro Thr Pro Pro Asp Asn Ile Gln Val Gln Glu Asn 
1               5                   10                  15      
Phe Asn Ile Ser Arg Ile Tyr Gly Lys Trp Tyr Asn Leu Ala Ile Gly 
            20                  25                  30          
Ser Thr Cys Pro Trp Leu Lys Lys Ile Lys Asp Arg Met Thr Val Ser 
        35                  40                  45              
Thr Leu Val Leu Gly Glu Gly Ala Thr Glu Ala Glu Ile Ser Met Thr 
    50                  55                  60                  
Ser Thr Arg Trp Arg Lys Gly Val Cys Glu Glu Thr Ser Gly Ala Tyr 
65                  70                  75                  80  
Glu Lys Thr Asp Thr Asp Gly Lys Phe Leu Tyr His Lys Ser Lys Trp 
                85                  90                  95      
Asn Ile Thr Met Glu Ser Tyr Val Val His Thr Asn Tyr Asp Glu Tyr 
            100                 105                 110         
Ala Ile Phe Leu Thr Lys Lys Phe Ser Arg His His Gly Pro Thr Ile 
        115                 120                 125             
Thr Ala Lys Leu Tyr Gly Arg Ala Pro Gln Leu Arg Glu Thr Leu Leu 
    130                 135                 140                 
Gln Asp Phe Arg Val Val Ala Gln Gly Val Gly Ile Pro Glu Asp Ser 
145                 150                 155                 160 
Ile Phe Thr Met Ala Asp Arg Gly Glu Cys Val Pro Gly Glu Gln Glu 
                165                 170                 175     
Pro Glu Pro Ile Leu Ile Pro Arg 
            180                 

<210> 5
<211> 195
<212> PRT
<213> Homo sapiens

<220> 
<223> 6His, N17,96D; R66H

<400> 5
Met His His His His His His Asp Asp Asp Asp Lys Gly Pro Val Pro 
1               5                   10                  15      
Thr Pro Pro Asp Asn Ile Gln Val Gln Glu Asn Phe Asp Ile Ser Arg 
            20                  25                  30          
Ile Tyr Gly Lys Trp Tyr Asn Leu Ala Ile Gly Ser Thr Cys Pro Trp 
        35                  40                  45              
Leu Lys Lys Ile Met Asp Arg Met Thr Val Ser Thr Leu Val Leu Gly 
    50                  55                  60                  
Glu Gly Ala Thr Glu Ala Glu Ile Ser Met Thr Ser Thr His Trp Arg 
65                  70                  75                  80  
Lys Gly Val Cys Glu Glu Thr Ser Gly Ala Tyr Glu Lys Thr Asp Thr 
                85                  90                  95      
Asp Gly Lys Phe Leu Tyr His Lys Ser Lys Trp Asp Ile Thr Met Glu 
            100                 105                 110         
Ser Tyr Val Val His Thr Asn Tyr Asp Glu Tyr Ala Ile Phe Leu Thr 
        115                 120                 125             
Lys Lys Phe Ser Arg His His Gly Pro Thr Ile Thr Ala Lys Leu Tyr 
    130                 135                 140                 
Gly Arg Ala Pro Gln Leu Arg Glu Thr Leu Leu Gln Asp Phe Arg Val 
145                 150                 155                 160 
Val Ala Gln Gly Val Gly Ile Pro Glu Asp Ser Ile Phe Thr Met Ala 
                165                 170                 175     
Asp Arg Gly Glu Cys Val Pro Gly Glu Gln Glu Pro Glu Pro Ile Leu 
            180                 185                 190         
Ile Pro Arg 
        195 

<210> 6
<211> 195
<212> PRT
<213> Homo sapiens

<220> 
<223> hA1M, 6His, M41K

<400> 6
Met His His His His His His Asp Asp Asp Asp Lys Gly Pro Val Pro 
1               5                   10                  15      
Thr Pro Pro Asp Asn Ile Gln Val Gln Glu Asn Phe Asn Ile Ser Arg 
            20                  25                  30          
Ile Tyr Gly Lys Trp Tyr Asn Leu Ala Ile Gly Ser Thr Cys Pro Trp 
        35                  40                  45              
Leu Lys Lys Ile Lys Asp Arg Met Thr Val Ser Thr Leu Val Leu Gly 
    50                  55                  60                  
Glu Gly Ala Thr Glu Ala Glu Ile Ser Met Thr Ser Thr Arg Trp Arg 
65                  70                  75                  80  
Lys Gly Val Cys Glu Glu Thr Ser Gly Ala Tyr Glu Lys Thr Asp Thr 
                85                  90                  95      
Asp Gly Lys Phe Leu Tyr His Lys Ser Lys Trp Asn Ile Thr Met Glu 
            100                 105                 110         
Ser Tyr Val Val His Thr Asn Tyr Asp Glu Tyr Ala Ile Phe Leu Thr 
        115                 120                 125             
Lys Lys Phe Ser Arg His His Gly Pro Thr Ile Thr Ala Lys Leu Tyr 
    130                 135                 140                 
Gly Arg Ala Pro Gln Leu Arg Glu Thr Leu Leu Gln Asp Phe Arg Val 
145                 150                 155                 160 
Val Ala Gln Gly Val Gly Ile Pro Glu Asp Ser Ile Phe Thr Met Ala 
                165                 170                 175     
Asp Arg Gly Glu Cys Val Pro Gly Glu Gln Glu Pro Glu Pro Ile Leu 
            180                 185                 190         
Ile Pro Arg 
        195 

<210> 7
<211> 197
<212> PRT
<213> Homo sapiens

<220> 
<223> 8His, N17,96D; R66H

<400> 7
Met His His His His His His His His Asp Asp Asp Asp Lys Gly Pro 
1               5                   10                  15      
Val Pro Thr Pro Pro Asp Asn Ile Gln Val Gln Glu Asn Phe Asp Ile 
            20                  25                  30          
Ser Arg Ile Tyr Gly Lys Trp Tyr Asn Leu Ala Ile Gly Ser Thr Cys 
        35                  40                  45              
Pro Trp Leu Lys Lys Ile Met Asp Arg Met Thr Val Ser Thr Leu Val 
    50                  55                  60                  
Leu Gly Glu Gly Ala Thr Glu Ala Glu Ile Ser Met Thr Ser Thr His 
65                  70                  75                  80  
Trp Arg Lys Gly Val Cys Glu Glu Thr Ser Gly Ala Tyr Glu Lys Thr 
                85                  90                  95      
Asp Thr Asp Gly Lys Phe Leu Tyr His Lys Ser Lys Trp Asp Ile Thr 
            100                 105                 110         
Met Glu Ser Tyr Val Val His Thr Asn Tyr Asp Glu Tyr Ala Ile Phe 
        115                 120                 125             
Leu Thr Lys Lys Phe Ser Arg His His Gly Pro Thr Ile Thr Ala Lys 
    130                 135                 140                 
Leu Tyr Gly Arg Ala Pro Gln Leu Arg Glu Thr Leu Leu Gln Asp Phe 
145                 150                 155                 160 
Arg Val Val Ala Gln Gly Val Gly Ile Pro Glu Asp Ser Ile Phe Thr 
                165                 170                 175     
Met Ala Asp Arg Gly Glu Cys Val Pro Gly Glu Gln Glu Pro Glu Pro 
            180                 185                 190         
Ile Leu Ile Pro Arg 
        195         

<210> 8
<211> 197
<212> PRT
<213> Homo sapiens

<220> 
<223> hA1M, 8His, M41K

<400> 8
Met His His His His His His His His Asp Asp Asp Asp Lys Gly Pro 
1               5                   10                  15      
Val Pro Thr Pro Pro Asp Asn Ile Gln Val Gln Glu Asn Phe Asn Ile 
            20                  25                  30          
Ser Arg Ile Tyr Gly Lys Trp Tyr Asn Leu Ala Ile Gly Ser Thr Cys 
        35                  40                  45              
Pro Trp Leu Lys Lys Ile Lys Asp Arg Met Thr Val Ser Thr Leu Val 
    50                  55                  60                  
Leu Gly Glu Gly Ala Thr Glu Ala Glu Ile Ser Met Thr Ser Thr Arg 
65                  70                  75                  80  
Trp Arg Lys Gly Val Cys Glu Glu Thr Ser Gly Ala Tyr Glu Lys Thr 
                85                  90                  95      
Asp Thr Asp Gly Lys Phe Leu Tyr His Lys Ser Lys Trp Asn Ile Thr 
            100                 105                 110         
Met Glu Ser Tyr Val Val His Thr Asn Tyr Asp Glu Tyr Ala Ile Phe 
        115                 120                 125             
Leu Thr Lys Lys Phe Ser Arg His His Gly Pro Thr Ile Thr Ala Lys 
    130                 135                 140                 
Leu Tyr Gly Arg Ala Pro Gln Leu Arg Glu Thr Leu Leu Gln Asp Phe 
145                 150                 155                 160 
Arg Val Val Ala Gln Gly Val Gly Ile Pro Glu Asp Ser Ile Phe Thr 
                165                 170                 175     
Met Ala Asp Arg Gly Glu Cys Val Pro Gly Glu Gln Glu Pro Glu Pro 
            180                 185                 190         
Ile Leu Ile Pro Arg 
        195         

<210> 9
<211> 197
<212> PRT
<213> Homo sapiens

<220> 
<223> hA1M, 8His, no mut

<400> 9
Met His His His His His His His His Asp Asp Asp Asp Lys Gly Pro 
1               5                   10                  15      
Val Pro Thr Pro Pro Asp Asn Ile Gln Val Gln Glu Asn Phe Asn Ile 
            20                  25                  30          
Ser Arg Ile Tyr Gly Lys Trp Tyr Asn Leu Ala Ile Gly Ser Thr Cys 
        35                  40                  45              
Pro Trp Leu Lys Lys Ile Met Asp Arg Met Thr Val Ser Thr Leu Val 
    50                  55                  60                  
Leu Gly Glu Gly Ala Thr Glu Ala Glu Ile Ser Met Thr Ser Thr Arg 
65                  70                  75                  80  
Trp Arg Lys Gly Val Cys Glu Glu Thr Ser Gly Ala Tyr Glu Lys Thr 
                85                  90                  95      
Asp Thr Asp Gly Lys Phe Leu Tyr His Lys Ser Lys Trp Asn Ile Thr 
            100                 105                 110         
Met Glu Ser Tyr Val Val His Thr Asn Tyr Asp Glu Tyr Ala Ile Phe 
        115                 120                 125             
Leu Thr Lys Lys Phe Ser Arg His His Gly Pro Thr Ile Thr Ala Lys 
    130                 135                 140                 
Leu Tyr Gly Arg Ala Pro Gln Leu Arg Glu Thr Leu Leu Gln Asp Phe 
145                 150                 155                 160 
Arg Val Val Ala Gln Gly Val Gly Ile Pro Glu Asp Ser Ile Phe Thr 
                165                 170                 175     
Met Ala Asp Arg Gly Glu Cys Val Pro Gly Glu Gln Glu Pro Glu Pro 
            180                 185                 190         
Ile Leu Ile Pro Arg 
        195         

<210> 10
<211> 193
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT
<222> 1
<223> Xaa = Met or absent

<220> 
<221> VARIANT
<222> 1
<223> Xaa = Met or absent

<220> 
<221> VARIANT
<222> 2
<223> Xaa = His or absent

<220> 
<221> VARIANT
<222> 2
<223> Xaa = His or absent

<220> 
<221> VARIANT
<222> 3
<223> Xaa = His or absent

<220> 
<221> VARIANT
<222> 3
<223> Xaa = His or absent

<220> 
<221> VARIANT
<222> 4
<223> Xaa = His or absent

<220> 
<221> VARIANT
<222> 4
<223> Xaa = His or absent

<220> 
<221> VARIANT
<222> 5
<223> Xaa = His or absent

<220> 
<221> VARIANT
<222> 5
<223> Xaa = His or absent

<220> 
<221> VARIANT
<222> 6
<223> Xaa = His or absent

<220> 
<221> VARIANT
<222> 6
<223> Xaa = His or absent

<220> 
<221> VARIANT
<222> 7
<223> Xaa = His or absent

<220> 
<221> VARIANT
<222> 7
<223> Xaa = His or absent

<220> 
<221> VARIANT
<222> 8
<223> Xaa = His or absent

<220> 
<221> VARIANT
<222> 8
<223> Xaa = His or absent

<220> 
<221> VARIANT
<222> 9
<223> Xaa = His or absent

<220> 
<221> VARIANT
<222> 9
<223> Xaa = His or absent

<220> 
<221> VARIANT
<222> 10
<223> Xaa = Asp, Glu, Lys, Arg, or absent

<220> 
<221> VARIANT
<222> 10
<223> Xaa = Asp, Glu, Lys, Arg, or absent

<220> 
<221> VARIANT
<222> 11
<223> Xaa = Asp, Glu, Lys, Arg, or absent

<220> 
<221> VARIANT
<222> 11
<223> Xaa = Asp, Glu, Lys, Arg, or absent

<220> 
<221> VARIANT
<222> 12
<223> Xaa = Asp, Glu, Lys, Arg, or absent

<220> 
<221> VARIANT
<222> 12
<223> Xaa = Asp, Glu, Lys, Arg, or absent

<220> 
<221> VARIANT
<222> 13
<223> Xaa = Asp, Glu, Lys, Arg, or absent

<220> 
<221> VARIANT
<222> 13
<223> Xaa = Asp, Glu, Lys, Arg, or absent

<220> 
<221> VARIANT
<222> 14
<223> Xaa = Asp, Glu, Lys, Arg, or absent

<220> 
<221> VARIANT
<222> 14
<223> Xaa = Asp, Glu, Lys, Arg, or absent

<220> 
<221> VARIANT
<222> 31
<223> Xaa = Asn or Asp

<220> 
<221> VARIANT
<222> 55
<223> Xaa = Met or Lys

<220> 
<221> VARIANT
<222> 80
<223> Xaa = Arg or His

<220> 
<221> VARIANT
<222> 110
<223> Xaa = Asn or Asp

<400> 10
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Gly Pro 
1               5                   10                  15      
Val Pro Thr Pro Pro Asp Asn Ile Gln Val Gln Glu Asn Phe Xaa Ile 
            20                  25                  30          
Ser Arg Ile Tyr Gly Lys Trp Tyr Asn Leu Ala Ile Gly Ser Thr Cys 
        35                  40                  45              
Pro Trp Leu Lys Lys Ile Xaa Asp Arg Met Thr Val Ser Thr Leu Val 
    50                  55                  60                  
Leu Gly Glu Gly Ala Thr Glu Ala Glu Ile Ser Met Thr Ser Thr Xaa 
65                  70                  75                  80  
Trp Arg Lys Gly Val Cys Glu Glu Thr Ser Gly Ala Tyr Glu Lys Thr 
                85                  90                  95      
Asp Thr Asp Gly Lys Phe Leu Tyr His Lys Ser Lys Trp Xaa Ile Thr 
            100                 105                 110         
Met Glu Ser Tyr Val Val His Thr Asn Tyr Asp Glu Tyr Ala Ile Phe 
        115                 120                 125             
Leu Thr Lys Lys Phe Ser Arg His His Gly Pro Thr Ile Thr Ala Lys 
    130                 135                 140                 
Leu Tyr Gly Arg Ala Pro Gln Leu Arg Glu Thr Leu Leu Gln Asp Phe 
145                 150                 155                 160 
Arg Val Val Ala Gln Gly Val Gly Ile Pro Glu Asp Ser Ile Phe Thr 
                165                 170                 175     
Met Ala Asp Arg Gly Glu Cys Val Pro Gly Glu Gln Glu Pro Glu Pro 
            180                 185                 190         
Ile Leu Ile Pro Arg 
        195         

<210> 11
<211> 16
<212> PRT
<213> Homo sapiens

<220> 
<223> Y1

<400> 11
Gly Pro Val Pro Thr Pro Pro Asp Asn Ile Gln Val Gln Glu Asn Phe 
1               5                   10                  15      



<210> 12
<211> 23
<212> PRT
<213> Homo sapiens

<220> 
<223> Y2

<400> 12
Ile Ser Arg Ile Tyr Gly Lys Trp Tyr Asn Leu Ala Ile Gly Ser Thr 
1               5                   10                  15      
Cys Pro Trp Leu Lys Lys Ile 
            20              

<210> 13
<211> 24
<212> PRT
<213> Homo sapiens

<220> 
<223> Y3

<400> 13
Asp Arg Met Thr Val Ser Thr Leu Val Leu Gly Glu Gly Ala Thr Glu 
1               5                   10                  15      
Ala Glu Ile Ser Met Thr Ser Thr 
            20                  

<210> 14
<211> 29
<212> PRT
<213> Homo sapiens
<220> 
<223> Y4

<400> 14
Trp Arg Lys Gly Val Cys Glu Glu Thr Ser Gly Ala Tyr Glu Lys Thr 
1               5                   10                  15      
Asp Thr Asp Gly Lys Phe Leu Tyr His Lys Ser Lys Trp 
            20                  25                  

<210> 15
<211> 87
<212> PRT
<213> Homo sapiens

<220> 
<223> Y5

<400> 15
Ile Thr Met Glu Ser Tyr Val Val His Thr Asn Tyr Asp Glu Tyr Ala 
1               5                   10                  15      
Ile Phe Leu Thr Lys Lys Phe Ser Arg His His Gly Pro Thr Ile Thr 
            20                  25                  30          
Ala Lys Leu Tyr Gly Arg Ala Pro Gln Leu Arg Glu Thr Leu Leu Gln 
        35                  40                  45              
Asp Phe Arg Val Val Ala Gln Gly Val Gly Ile Pro Glu Asp Ser Ile 
    50                  55                  60                  
Phe Thr Met Ala Asp Arg Gly Glu Cys Val Pro Gly Glu Gln Glu Pro 
65                  70                  75                  80  
Glu Pro Ile Leu Ile Pro Arg 
                85          


<210> 16
<211> 83
<212> PRT
<213> Homo sapiens

<220> 
<223> Y5

<400> 16
Ile Thr Met Glu Ser Tyr Val Val His Thr Asn Tyr Asp Glu Tyr Ala 
1               5                   10                  15      
Ile Phe Leu Thr Lys Lys Phe Ser Arg His His Gly Pro Thr Ile Thr 
            20                  25                  30          
Ala Lys Leu Tyr Gly Arg Ala Pro Gln Leu Arg Glu Thr Leu Leu Gln 
        35                  40                  45              
Asp Phe Arg Val Val Ala Gln Gly Val Gly Ile Pro Glu Asp Ser Ile 
    50                  55                  60                  
Phe Thr Met Ala Asp Arg Gly Glu Cys Val Pro Gly Glu Gln Glu Pro 
65                  70                  75                  80  
Glu Pro Ile Leu Ile Pro Arg 
                85          



<210> 17
<211> 197
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT
<222> 1
<223> Xaa = Met or absent

<220> 
<221> VARIANT
<222> 1
<223> Xaa = Met or absent

<220> 
<221> VARIANT
<222> 2
<223> Xaa = His or absent

<220> 
<221> VARIANT
<222> 2
<223> Xaa = His or absent

<220> 
<221> VARIANT
<222> 3
<223> Xaa = His or absent

<220> 
<221> VARIANT
<222> 3
<223> Xaa = His or absent

<220> 
<221> VARIANT
<222> 4
<223> Xaa = His or absent

<220> 
<221> VARIANT
<222> 4
<223> Xaa = His or absent

<220> 
<221> VARIANT
<222> 5
<223> Xaa = His or absent

<220> 
<221> VARIANT
<222> 5
<223> Xaa = His or absent

<220> 
<221> VARIANT
<222> 6
<223> Xaa = His or absent

<220> 
<221> VARIANT
<222> 6
<223> Xaa = His or absent

<220> 
<221> VARIANT
<222> 7
<223> Xaa = His or absent

<220> 
<221> VARIANT
<222> 7
<223> Xaa = His or absent

<220> 
<221> VARIANT
<222> 8
<223> Xaa = His or absent

<220> 
<221> VARIANT
<222> 8
<223> Xaa = His or absent

<220> 
<221> VARIANT
<222> 9
<223> Xaa = His or absent

<220> 
<221> VARIANT
<222> 9
<223> Xaa = His or absent

<220> 
<221> VARIANT
<222> 10
<223> Xaa = Asp, Glu, Lys, Arg, or absent

<220> 
<221> VARIANT
<222> 10
<223> Xaa = Asp, Glu, Lys, Arg, or absent

<220> 
<221> VARIANT
<222> 11
<223> Xaa = Asp, Glu, Lys, Arg, or absent

<220> 
<221> VARIANT
<222> 11
<223> Xaa = Asp, Glu, Lys, Arg, or absent

<220> 
<221> VARIANT
<222> 12
<223> Xaa = Asp, Glu, Lys, Arg, or absent

<220> 
<221> VARIANT
<222> 12
<223> Xaa = Asp, Glu, Lys, Arg, or absent

<220> 
<221> VARIANT
<222> 13
<223> Xaa = Asp, Glu, Lys, Arg, or absent

<220> 
<221> VARIANT
<222> 13
<223> Xaa = Asp, Glu, Lys, Arg, or absent

<220> 
<221> VARIANT
<222> 14
<223> Xaa = Asp, Glu, Lys, Arg, or absent

<220> 
<221> VARIANT
<222> 14
<223> Xaa = Asp, Glu, Lys, Arg, or absent

<220> 
<221> VARIANT
<222> 31
<223> Xaa = Asn or Asp

<220> 
<221> VARIANT
<222> 55
<223> Xaa = Met or Lys

<220> 
<221> VARIANT
<222> 80
<223> Xaa = Arg or His

<220> 
<221> VARIANT
<222> 110
<223> Xaa = Asn or Asp

<400> 17
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Gly Pro 
1               5                   10                  15      
Val Pro Thr Pro Pro Asp Asn Ile Gln Val Gln Glu Asn Phe Xaa Ile 
            20                  25                  30          
Ser Arg Ile Tyr Gly Lys Trp Tyr Asn Leu Ala Ile Gly Ser Thr Cys 
        35                  40                  45              
Pro Trp Leu Lys Lys Ile Xaa Asp Arg Met Thr Val Ser Thr Leu Val 
    50                  55                  60                  
Leu Gly Glu Gly Ala Thr Glu Ala Glu Ile Ser Met Thr Ser Thr Xaa 
65                  70                  75                  80  
Trp Arg Lys Gly Val Cys Glu Glu Thr Ser Gly Ala Tyr Glu Lys Thr 
                85                  90                  95      
Asp Thr Asp Gly Lys Phe Leu Tyr His Lys Ser Lys Trp Xaa Ile Thr 
            100                 105                 110         
Met Glu Ser Tyr Val Val His Thr Asn Tyr Asp Glu Tyr Ala Ile Phe 
        115                 120                 125             
Leu Thr Lys Lys Phe Ser Arg His His Gly Pro Thr Ile Thr Ala Lys 
    130                 135                 140                 
Leu Tyr Gly Arg Ala Pro Gln Leu Arg Glu Thr Leu Leu Gln Asp Phe 
145                 150                 155                 160 
Arg Val Val Ala Gln Gly Val Gly Ile Pro Glu Asp Ser Ile Phe Thr 
                165                 170                 175     
Met Ala Asp Arg Gly Glu Cys Val Pro Gly Glu Gln Glu Pro Glu Pro 
            180                 185                 190         
Ile
      

<210> 18
<211> 180
<212> PRT
<213> Homo sapiens

<220> 
<223> hA1M, No tag, N-terminal Met, N17,96D; R66H; truncated

<400> 18
Met Gly Pro Val Pro Thr Pro Pro Asp Asn Ile Gln Val Gln Glu Asn 
1               5                   10                  15      
Phe Asp Ile Ser Arg Ile Tyr Gly Lys Trp Tyr Asn Leu Ala Ile Gly 
            20                  25                  30          
Ser Thr Cys Pro Trp Leu Lys Lys Ile Met Asp Arg Met Thr Val Ser 
        35                  40                  45              
Thr Leu Val Leu Gly Glu Gly Ala Thr Glu Ala Glu Ile Ser Met Thr 
    50                  55                  60                  
Ser Thr His Trp Arg Lys Gly Val Cys Glu Glu Thr Ser Gly Ala Tyr 
65                  70                  75                  80  
Glu Lys Thr Asp Thr Asp Gly Lys Phe Leu Tyr His Lys Ser Lys Trp 
                85                  90                  95      
Asp Ile Thr Met Glu Ser Tyr Val Val His Thr Asn Tyr Asp Glu Tyr 
            100                 105                 110         
Ala Ile Phe Leu Thr Lys Lys Phe Ser Arg His His Gly Pro Thr Ile 
        115                 120                 125             
Thr Ala Lys Leu Tyr Gly Arg Ala Pro Gln Leu Arg Glu Thr Leu Leu 
    130                 135                 140                 
Gln Asp Phe Arg Val Val Ala Gln Gly Val Gly Ile Pro Glu Asp Ser 
145                 150                 155                 160 
Ile Phe Thr Met Ala Asp Arg Gly Glu Cys Val Pro Gly Glu Gln Glu 
                165                 170                 175     
Pro Glu Pro Ile  
            180                 

<210> 19
<211> 180
<212> PRT
<213> Homo sapiens

<220> 
<223> hA1M, not tag, N-terminal Met, M41K; truncated 

<400> 19
Met Gly Pro Val Pro Thr Pro Pro Asp Asn Ile Gln Val Gln Glu Asn 
1               5                   10                  15      
Phe Asn Ile Ser Arg Ile Tyr Gly Lys Trp Tyr Asn Leu Ala Ile Gly 
            20                  25                  30          
Ser Thr Cys Pro Trp Leu Lys Lys Ile Lys Asp Arg Met Thr Val Ser 
        35                  40                  45              
Thr Leu Val Leu Gly Glu Gly Ala Thr Glu Ala Glu Ile Ser Met Thr 
    50                  55                  60                  
Ser Thr Arg Trp Arg Lys Gly Val Cys Glu Glu Thr Ser Gly Ala Tyr 
65                  70                  75                  80  
Glu Lys Thr Asp Thr Asp Gly Lys Phe Leu Tyr His Lys Ser Lys Trp 
                85                  90                  95      
Asn Ile Thr Met Glu Ser Tyr Val Val His Thr Asn Tyr Asp Glu Tyr 
            100                 105                 110         
Ala Ile Phe Leu Thr Lys Lys Phe Ser Arg His His Gly Pro Thr Ile 
        115                 120                 125             
Thr Ala Lys Leu Tyr Gly Arg Ala Pro Gln Leu Arg Glu Thr Leu Leu 
    130                 135                 140                 
Gln Asp Phe Arg Val Val Ala Gln Gly Val Gly Ile Pro Glu Asp Ser 
145                 150                 155                 160 
Ile Phe Thr Met Ala Asp Arg Gly Glu Cys Val Pro Gly Glu Gln Glu 
                165                 170                 175     
Pro Glu Pro Ile Leu Ile Pro Arg 
            180                 

<210> 20
<211> 191
<212> PRT
<213> Homo sapiens

<220> 
<223> 6His, N17,96D; R66H;  truncated

<400> 20
Met His His His His His His Asp Asp Asp Asp Lys Gly Pro Val Pro 
1               5                   10                  15      
Thr Pro Pro Asp Asn Ile Gln Val Gln Glu Asn Phe Asp Ile Ser Arg 
            20                  25                  30          
Ile Tyr Gly Lys Trp Tyr Asn Leu Ala Ile Gly Ser Thr Cys Pro Trp 
        35                  40                  45              
Leu Lys Lys Ile Met Asp Arg Met Thr Val Ser Thr Leu Val Leu Gly 
    50                  55                  60                  
Glu Gly Ala Thr Glu Ala Glu Ile Ser Met Thr Ser Thr His Trp Arg 
65                  70                  75                  80  
Lys Gly Val Cys Glu Glu Thr Ser Gly Ala Tyr Glu Lys Thr Asp Thr 
                85                  90                  95      
Asp Gly Lys Phe Leu Tyr His Lys Ser Lys Trp Asp Ile Thr Met Glu 
            100                 105                 110         
Ser Tyr Val Val His Thr Asn Tyr Asp Glu Tyr Ala Ile Phe Leu Thr 
        115                 120                 125             
Lys Lys Phe Ser Arg His His Gly Pro Thr Ile Thr Ala Lys Leu Tyr 
    130                 135                 140                 
Gly Arg Ala Pro Gln Leu Arg Glu Thr Leu Leu Gln Asp Phe Arg Val 
145                 150                 155                 160 
Val Ala Gln Gly Val Gly Ile Pro Glu Asp Ser Ile Phe Thr Met Ala 
                165                 170                 175     
Asp Arg Gly Glu Cys Val Pro Gly Glu Gln Glu Pro Glu Pro Ile
            180                 185                 190         
 
      

<210> 21
<211> 191
<212> PRT
<213> Homo sapiens

<220> 
<223> hA1M, 6His, M41K; truncated

<400> 21
Met His His His His His His Asp Asp Asp Asp Lys Gly Pro Val Pro 
1               5                   10                  15      
Thr Pro Pro Asp Asn Ile Gln Val Gln Glu Asn Phe Asn Ile Ser Arg 
            20                  25                  30          
Ile Tyr Gly Lys Trp Tyr Asn Leu Ala Ile Gly Ser Thr Cys Pro Trp 
        35                  40                  45              
Leu Lys Lys Ile Lys Asp Arg Met Thr Val Ser Thr Leu Val Leu Gly 
    50                  55                  60                  
Glu Gly Ala Thr Glu Ala Glu Ile Ser Met Thr Ser Thr Arg Trp Arg 
65                  70                  75                  80  
Lys Gly Val Cys Glu Glu Thr Ser Gly Ala Tyr Glu Lys Thr Asp Thr 
                85                  90                  95      
Asp Gly Lys Phe Leu Tyr His Lys Ser Lys Trp Asn Ile Thr Met Glu 
            100                 105                 110         
Ser Tyr Val Val His Thr Asn Tyr Asp Glu Tyr Ala Ile Phe Leu Thr 
        115                 120                 125             
Lys Lys Phe Ser Arg His His Gly Pro Thr Ile Thr Ala Lys Leu Tyr 
    130                 135                 140                 
Gly Arg Ala Pro Gln Leu Arg Glu Thr Leu Leu Gln Asp Phe Arg Val 
145                 150                 155                 160 
Val Ala Gln Gly Val Gly Ile Pro Glu Asp Ser Ile Phe Thr Met Ala 
                165                 170                 175     
Asp Arg Gly Glu Cys Val Pro Gly Glu Gln Glu Pro Glu Pro Ile Leu 
            180                 185                 190         
Ile Pro Arg 
        195 


<210> 22
<211> 193
<212> PRT
<213> Homo sapiens

<220> 
<223> 8His, N17,96D; R66H; truncated

<400> 22
Met His His His His His His His His Asp Asp Asp Asp Lys Gly Pro 
1               5                   10                  15      
Val Pro Thr Pro Pro Asp Asn Ile Gln Val Gln Glu Asn Phe Asp Ile 
            20                  25                  30          
Ser Arg Ile Tyr Gly Lys Trp Tyr Asn Leu Ala Ile Gly Ser Thr Cys 
        35                  40                  45              
Pro Trp Leu Lys Lys Ile Met Asp Arg Met Thr Val Ser Thr Leu Val 
    50                  55                  60                  
Leu Gly Glu Gly Ala Thr Glu Ala Glu Ile Ser Met Thr Ser Thr His 
65                  70                  75                  80  
Trp Arg Lys Gly Val Cys Glu Glu Thr Ser Gly Ala Tyr Glu Lys Thr 
                85                  90                  95      
Asp Thr Asp Gly Lys Phe Leu Tyr His Lys Ser Lys Trp Asp Ile Thr 
            100                 105                 110         
Met Glu Ser Tyr Val Val His Thr Asn Tyr Asp Glu Tyr Ala Ile Phe 
        115                 120                 125             
Leu Thr Lys Lys Phe Ser Arg His His Gly Pro Thr Ile Thr Ala Lys 
    130                 135                 140                 
Leu Tyr Gly Arg Ala Pro Gln Leu Arg Glu Thr Leu Leu Gln Asp Phe 
145                 150                 155                 160 
Arg Val Val Ala Gln Gly Val Gly Ile Pro Glu Asp Ser Ile Phe Thr 
                165                 170                 175     
Met Ala Asp Arg Gly Glu Cys Val Pro Gly Glu Gln Glu Pro Glu Pro 
            180                 185                 190         
Ile 
          

<210> 23
<211> 193
<212> PRT
<213> Homo sapiens

<220> 
<223> hA1M, 8His, M41K; truncated

<400> 23
Met His His His His His His His His Asp Asp Asp Asp Lys Gly Pro 
1               5                   10                  15      
Val Pro Thr Pro Pro Asp Asn Ile Gln Val Gln Glu Asn Phe Asn Ile 
            20                  25                  30          
Ser Arg Ile Tyr Gly Lys Trp Tyr Asn Leu Ala Ile Gly Ser Thr Cys 
        35                  40                  45              
Pro Trp Leu Lys Lys Ile Lys Asp Arg Met Thr Val Ser Thr Leu Val 
    50                  55                  60                  
Leu Gly Glu Gly Ala Thr Glu Ala Glu Ile Ser Met Thr Ser Thr Arg 
65                  70                  75                  80  
Trp Arg Lys Gly Val Cys Glu Glu Thr Ser Gly Ala Tyr Glu Lys Thr 
                85                  90                  95      
Asp Thr Asp Gly Lys Phe Leu Tyr His Lys Ser Lys Trp Asn Ile Thr 
            100                 105                 110         
Met Glu Ser Tyr Val Val His Thr Asn Tyr Asp Glu Tyr Ala Ile Phe 
        115                 120                 125             
Leu Thr Lys Lys Phe Ser Arg His His Gly Pro Thr Ile Thr Ala Lys 
    130                 135                 140                 
Leu Tyr Gly Arg Ala Pro Gln Leu Arg Glu Thr Leu Leu Gln Asp Phe 
145                 150                 155                 160 
Arg Val Val Ala Gln Gly Val Gly Ile Pro Glu Asp Ser Ile Phe Thr 
                165                 170                 175     
Met Ala Asp Arg Gly Glu Cys Val Pro Gly Glu Gln Glu Pro Glu Pro 
            180                 185                 190         
Ile Leu Ile Pro Arg 
        195         



<210> 24
<211> 200
<212> PRT
<213> Mus <mouse, genus>

<220> 
<223> 1.M8H5GIEGR-Mouse

<400> 24
Met His His His His His His His His Gly Gly Gly Gly Gly Ile Glu 
1               5                   10                  15      
Gly Arg Asp Pro Ala Ser Thr Leu Pro Asp Ile Gln Val Gln Glu Asn 
            20                  25                  30          
Phe Ser Glu Ser Arg Ile Tyr Gly Lys Trp Tyr Asn Leu Ala Val Gly 
        35                  40                  45              
Ser Thr Cys Pro Trp Leu Ser Arg Ile Lys Asp Lys Met Ser Val Gln 
    50                  55                  60                  
Thr Leu Val Leu Gln Glu Gly Ala Thr Glu Thr Glu Ile Ser Met Thr 
65                  70                  75                  80  
Ser Thr Arg Trp Arg Arg Gly Val Cys Glu Glu Ile Thr Gly Ala Tyr 
                85                  90                  95      
Gln Lys Thr Asp Ile Asp Gly Lys Phe Leu Tyr His Lys Ser Lys Trp 
            100                 105                 110         
Asn Ile Thr Leu Glu Ser Tyr Val Val His Thr Asn Tyr Asp Glu Tyr 
        115                 120                 125             
Ala Ile Phe Leu Thr Lys Lys Ser Ser His His His Gly Leu Thr Ile 
    130                 135                 140                 
Thr Ala Lys Leu Tyr Gly Arg Glu Pro Gln Leu Arg Asp Ser Leu Leu 
145                 150                 155                 160 
Gln Glu Phe Lys Asp Val Ala Leu Asn Val Gly Ile Ser Glu Asn Ser 
                165                 170                 175     
Ile Ile Phe Met Pro Asp Arg Gly Glu Cys Val Pro Gly Asp Arg Glu 
            180                 185                 190         
Val Glu Pro Thr Ser Ile Ala Arg 
        195                 200 

<210> 25
<211> 201
<212> PRT
<213> Heterocephalus glaber

<220> 
<223> 2. M8H5GIEGR-Naked Mole rat

<400> 25
Met His His His His His His His His Gly Gly Gly Gly Gly Ile Glu 
1               5                   10                  15      
Gly Arg Asn Pro Val Pro Met Pro Pro Asp Asn Ile Gln Val Gln Glu 
            20                  25                  30          
Asn Phe Asp Glu Ser Arg Ile Tyr Gly Lys Trp Phe Asn Leu Ala Thr 
        35                  40                  45              
Gly Ser Thr Cys Pro Trp Leu Lys Arg Ile Lys Asp Arg Leu Ser Val 
    50                  55                  60                  
Ser Thr Met Val Leu Gly Lys Gly Thr Thr Glu Thr Gln Ile Ser Thr 
65                  70                  75                  80  
Thr His Thr His Trp Arg Gln Gly Val Cys Gln Glu Thr Ser Gly Val 
                85                  90                  95      
Tyr Lys Lys Thr Asp Thr Ala Gly Lys Phe Leu Tyr His Lys Ser Lys 
            100                 105                 110         
Trp Asn Val Thr Met Glu Ser Tyr Val Val His Thr Asn Tyr Asp Glu 
        115                 120                 125             
Tyr Ala Ile Ile Leu Thr Lys Lys Phe Ser His His His Gly Pro Thr 
    130                 135                 140                 
Ile Thr Ala Lys Leu Tyr Gly Arg Glu Pro Arg Leu Arg Asp Ser Leu 
145                 150                 155                 160 
Leu Gln Glu Phe Arg Glu Met Ala Leu Gly Val Gly Ile Pro Glu Asp 
                165                 170                 175     
Ser Ile Phe Thr Met Ala Asn Arg Gly Glu Cys Val Pro Gly Asp Gln 
            180                 185                 190         
Ala Pro Glu Ser Thr Pro Ala Pro Arg 
        195                 200     

<210> 26
<211> 197
<212> PRT
<213> Anura

<220> 
<223> 3. M8H5GIEGR-Frog

<400> 26
Met His His His His His His His His Gly Gly Gly Gly Gly Ile Glu 
1               5                   10                  15      
Gly Arg Cys Ser Pro Ile Gln Pro Glu Asp Asn Ile Gln Ile Gln Glu 
            20                  25                  30          
Asn Phe Asp Leu Gln Arg Ile Tyr Gly Lys Trp Tyr Asp Ile Ala Ile 
        35                  40                  45              
Gly Ser Thr Cys Lys Trp Leu Lys His His Lys Glu Lys Phe Asn Met 
    50                  55                  60                  
Gly Thr Leu Glu Leu Ser Asp Gly Glu Thr Asp Gly Glu Val Arg Ile 
65                  70                  75                  80  
Val Asn Thr Arg Met Arg His Gly Thr Cys Ser Gln Ile Val Gly Ser 
                85                  90                  95      
Tyr Gln Lys Thr Glu Thr Pro Gly Lys Phe Asp Tyr Phe Asn Ala Arg 
            100                 105                 110         
Trp Gly Thr Thr Ile Gln Asn Tyr Ile Val Phe Thr Asn Tyr Asn Glu 
        115                 120                 125             
Tyr Val Ile Met Gln Met Arg Lys Lys Lys Gly Ser Glu Thr Thr Thr 
    130                 135                 140                 
Thr Val Lys Leu Tyr Gly Arg Ser Pro Asp Leu Arg Pro Thr Leu Val 
145                 150                 155                 160 
Asp Glu Phe Arg Gln Phe Ala Leu Ala Gln Gly Ile Pro Glu Asp Ser 
                165                 170                 175     
Ile Val Met Leu Pro Asn Asn Gly Glu Cys Ser Pro Gly Glu Ile Glu 
            180                 185                 190         
Val Arg Pro Arg Arg 
        195         

<210> 27
<211> 197
<212> PRT
<213> Gallus

<220> 
<223> 4. M8H5GIEGR-Chicken

<400> 27
Met His His His His His His His His Gly Gly Gly Gly Gly Ile Glu 
1               5                   10                  15      
Gly Arg Thr Pro Val Gly Asp Gln Asp Glu Asp Ile Gln Val Gln Glu 
            20                  25                  30          
Asn Phe Glu Pro Glu Arg Met Tyr Gly Lys Trp Tyr Asp Val Ala Val 
        35                  40                  45              
Gly Thr Thr Cys Lys Trp Met Lys Asn Tyr Lys Glu Lys Phe Ser Met 
    50                  55                  60                  
Gly Thr Leu Val Leu Gly Pro Gly Pro Ser Ala Asp Gln Ile Ser Thr 
65                  70                  75                  80  
Ile Ser Thr Arg Leu Arg Gln Gly Asp Cys Lys Arg Val Ser Gly Glu 
                85                  90                  95      
Tyr Gln Lys Thr Asp Thr Pro Gly Lys Tyr Thr Tyr Tyr Asn Pro Lys 
            100                 105                 110         
Trp Asp Val Ser Ile Lys Ser Tyr Val Leu Arg Thr Asn Tyr Glu Glu 
        115                 120                 125             
Tyr Ala Val Ile Leu Met Lys Lys Thr Ser Asn Phe Gly Pro Thr Thr 
    130                 135                 140                 
Thr Leu Lys Leu Tyr Gly Arg Ser Pro Glu Leu Arg Glu Glu Leu Thr 
145                 150                 155                 160 
Glu Ala Phe Gln Gln Leu Ala Leu Glu Met Gly Ile Pro Ala Asp Ser 
                165                 170                 175     
Val Phe Ile Leu Ala Asn Lys Gly Glu Cys Val Pro Gln Glu Thr Ala 
            180                 185                 190         
Thr Ala Pro Glu Arg 
        195         

<210> 28
<211> 201
<212> PRT
<213> Oryctolagus cuniculus

<220> 
<223> 5. M8H5GIEGR-Rabbit

<400> 28
Met His His His His His His His His Gly Gly Gly Gly Gly Ile Glu 
1               5                   10                  15      
Gly Arg Asp Pro Val Pro Thr Leu Pro Asp Asp Ile Gln Val Gln Glu 
            20                  25                  30          
Asn Phe Glu Leu Ser Arg Ile Tyr Gly Lys Trp Tyr Asn Leu Ala Val 
        35                  40                  45              
Gly Ser Thr Cys Pro Trp Leu Lys Arg Ile Lys Asp Arg Met Ala Val 
    50                  55                  60                  
Ser Thr Leu Val Leu Gly Glu Gly Thr Ser Glu Thr Glu Ile Ser Met 
65                  70                  75                  80  
Thr Ser Thr His Trp Arg Arg Gly Val Cys Glu Glu Ile Ser Gly Ala 
                85                  90                  95      
Tyr Glu Lys Thr Asp Thr Asp Gly Lys Phe Leu Tyr His Lys Ala Lys 
            100                 105                 110         
Trp Asn Leu Thr Met Glu Ser Tyr Val Val His Thr Asn Tyr Asp Glu 
        115                 120                 125             
Tyr Ala Ile Phe Leu Thr Lys Lys Phe Ser Arg Arg His Gly Pro Thr 
    130                 135                 140                 
Ile Thr Ala Lys Leu Tyr Gly Arg Glu Pro Gln Leu Arg Glu Ser Leu 
145                 150                 155                 160 
Leu Gln Glu Phe Arg Glu Val Ala Leu Gly Val Gly Ile Pro Glu Asn 
                165                 170                 175     
Ser Ile Phe Thr Met Ile Asp Arg Gly Glu Cys Val Pro Gly Gln Gln 
            180                 185                 190         
Glu Pro Lys Pro Ala Pro Val Leu Arg 
        195                 200     

<210> 29
<211> 201
<212> PRT
<213> Saimiri

<220> 
<223> 6. M8H5GIEGR-SQ Monkey

<400> 29
Met His His His His His His His His Gly Gly Gly Gly Gly Ile Glu 
1               5                   10                  15      
Gly Arg Ser Pro Val Pro Thr Pro Pro Glu Gly Ile Gln Val Gln Glu 
            20                  25                  30          
Asn Phe Asn Leu Ser Arg Ile Tyr Gly Lys Trp Tyr Asn Leu Ala Ile 
        35                  40                  45              
Gly Ser Thr Cys Pro Trp Leu Lys Lys Ile Met Asp Arg Leu Lys Val 
    50                  55                  60                  
Ser Thr Leu Val Leu Glu Glu Gly Ala Thr Glu Ala Glu Ile Ser Met 
65                  70                  75                  80  
Thr Ser Thr Arg Trp Arg Lys Gly Phe Cys Glu Gln Thr Ser Trp Ala 
                85                  90                  95      
Tyr Glu Lys Thr Asp Thr Asp Gly Lys Phe Leu Tyr His Glu Pro Lys 
            100                 105                 110         
Trp Asn Val Thr Met Glu Ser Tyr Val Ala His Thr Asn Tyr Glu Glu 
        115                 120                 125             
Tyr Ala Ile Phe Leu Thr Lys Lys Phe Ser Arg His His Gly Pro Thr 
    130                 135                 140                 
Ile Thr Ala Lys Leu Tyr Gly Arg Glu Pro Gln Leu Arg Glu Ser Leu 
145                 150                 155                 160 
Leu Gln Asp Phe Arg Val Val Ala Gln Gly Val Gly Ile Pro Glu Asp 
                165                 170                 175     
Ser Ile Phe Thr Met Ala Asn Arg Gly Glu Cys Val Pro Gly Glu Gln 
            180                 185                 190         
Glu Pro Gln Pro Ile Leu His Arg Arg 
        195                 200     

<210> 30
<211> 201
<212> PRT
<213> Odobenus

<220> 
<223> 7. M8H5GIEGR-Walrus

<400> 30
Met His His His His His His His His Gly Gly Gly Gly Gly Ile Glu 
1               5                   10                  15      
Gly Arg Ser Pro Val Leu Thr Pro Pro Asp Ala Ile Gln Val Gln Glu 
            20                  25                  30          
Asn Phe Asp Ile Ser Arg Ile Tyr Gly Lys Trp Phe His Val Ala Met 
        35                  40                  45              
Gly Ser Thr Cys Pro Trp Leu Lys Lys Phe Met Asp Arg Met Ser Met 
    50                  55                  60                  
Ser Thr Leu Val Leu Gly Glu Gly Ala Thr Asp Gly Glu Ile Ser Met 
65                  70                  75                  80  
Thr Ser Thr Arg Trp Arg Arg Gly Thr Cys Glu Glu Ile Ser Gly Ala 
                85                  90                  95      
Tyr Glu Lys Thr Ser Thr Asn Gly Lys Phe Leu Tyr His Asn Pro Lys 
            100                 105                 110         
Trp Asn Ile Thr Met Glu Ser Tyr Val Val His Thr Asp Tyr Asp Glu 
        115                 120                 125             
Tyr Ala Ile Phe Leu Thr Lys Lys Phe Ser Arg His His Gly Pro Thr 
    130                 135                 140                 
Ile Thr Ala Lys Leu Tyr Gly Arg Gln Pro Gln Leu Arg Glu Ser Leu 
145                 150                 155                 160 
Leu Glu Glu Phe Arg Glu Leu Ala Leu Gly Val Gly Ile Pro Glu Asp 
                165                 170                 175     
Ser Ile Phe Thr Met Ala Asn Lys Gly Glu Cys Val Pro Gly Glu Gln 
            180                 185                 190         
Glu Pro Glu Pro Ser Pro His Met Arg 
        195                 200     

<210> 31
<211> 200
<212> PRT
<213> Trichechus

<220> 
<223> 8. M8H5GIEGR-Manatee

<400> 31
Met His His His His His His His His Gly Gly Gly Gly Gly Ile Glu 
1               5                   10                  15      
Gly Arg Ser Pro Val Lys Thr Pro Leu Asn Asp Ile Gln Val Gln Glu 
            20                  25                  30          
Asn Phe Asp Leu Pro Arg Ile Tyr Gly Lys Trp Phe Asn Ile Ala Ile 
        35                  40                  45              
Gly Ser Thr Cys Gln Trp Leu Lys Arg Leu Lys Ala Gly Pro Thr Met 
    50                  55                  60                  
Ser Thr Leu Val Leu Gly Glu Gly Ala Thr Asp Thr Glu Ile Ser Thr 
65                  70                  75                  80  
Thr Ser Thr Arg Trp Arg Lys Gly Phe Cys Glu Glu Ile Ser Gly Ala 
                85                  90                  95      
Tyr Glu Lys Thr Asp Thr Ala Gly Lys Phe Leu Tyr His Gly Ser Lys 
            100                 105                 110         
Trp Asn Val Thr Leu Glu Ser Tyr Val Val His Thr Asn Tyr Asp Glu 
        115                 120                 125             
Tyr Ala Ile Phe Leu Thr Lys Lys Phe Ser Arg Tyr Gly Leu Thr Ile 
    130                 135                 140                 
Thr Ala Lys Leu Tyr Gly Arg Gln Pro Gln Val Arg Glu Ser Leu Leu 
145                 150                 155                 160 
Glu Glu Phe Arg Glu Phe Ala Leu Gly Val Gly Ile Pro Glu Asp Ser 
                165                 170                 175     
Ile Phe Thr Thr Ala Asp Lys Gly Glu Cys Val Pro Gly Glu Gln Glu 
            180                 185                 190         
Pro Glu Pro Thr Ala Ala Leu Arg 
        195                 200 

<210> 32
<211> 202
<212> PRT
<213> Pleuronectes platessa

<220> 
<223> 9. M8H5GIEGR-Plaice

<400> 32
Met His His His His His His His His Gly Gly Gly Gly Gly Ile Glu 
1               5                   10                  15      
Gly Arg Leu Pro Val Leu Pro Glu Pro Leu Tyr Pro Thr Gln Glu Asn 
            20                  25                  30          
Phe Asp Leu Thr Arg Phe Val Gly Thr Trp His Asp Val Ala Leu Thr 
        35                  40                  45              
Ser Ser Cys Pro His Met Gln Arg Asn Arg Ala Asp Ala Ala Ile Gly 
    50                  55                  60                  
Lys Leu Val Leu Glu Lys Asp Thr Gly Asn Lys Leu Lys Val Thr Arg 
65                  70                  75                  80  
Thr Arg Leu Arg His Gly Thr Cys Val Glu Met Ser Gly Glu Tyr Glu 
                85                  90                  95      
Leu Thr Ser Thr Pro Gly Arg Ile Phe Tyr His Ile Asp Arg Trp Asp 
            100                 105                 110         
Ala Asp Val Asp Ala Tyr Val Val His Thr Asn Tyr Asp Glu Tyr Ala 
        115                 120                 125             
Ile Ile Ile Met Ser Lys Gln Lys Thr Ser Gly Glu Asn Ser Thr Ser 
    130                 135                 140                 
Leu Lys Leu Tyr Ser Arg Thr Met Ser Val Arg Asp Thr Val Leu Asp 
145                 150                 155                 160 
Asp Phe Lys Thr Leu Val Arg His Gln Gly Met Ser Asp Asp Thr Ile 
                165                 170                 175     
Ile Ile Lys Gln Asn Lys Gly Asp Cys Ile Pro Gly Glu Gln Val Glu 
            180                 185                 190         
Glu Ala Pro Ser Gln Pro Glu Pro Lys Arg 
        195                 200         

<210> 33
<211> 201
<212> PRT
<213> Pongo

<220> 
<223> 10. M8H5GIEGR-Orangutan

<400> 33
Met His His His His His His His His Gly Gly Gly Gly Gly Ile Glu 
1               5                   10                  15      
Gly Arg Gly Pro Val Pro Thr Pro Pro Asp Asn Ile Gln Val Gln Glu 
            20                  25                  30          
Asn Phe Asn Ile Ser Arg Ile Tyr Gly Lys Trp Tyr Asn Leu Ala Ile 
        35                  40                  45              
Gly Ser Thr Cys Pro Trp Leu Lys Lys Ile Met Asp Arg Met Thr Val 
    50                  55                  60                  
Ser Thr Leu Val Leu Gly Glu Gly Ala Thr Glu Ala Glu Ile Ser Met 
65                  70                  75                  80  
Thr Ser Thr Arg Trp Arg Lys Gly Val Cys Glu Glu Thr Ser Gly Ala 
                85                  90                  95      
Tyr Glu Lys Thr Asp Thr Asp Gly Lys Phe Leu Tyr His Lys Ser Lys 
            100                 105                 110         
Trp Asn Ile Thr Met Glu Ser Tyr Val Val His Thr Asn Tyr Asp Glu 
        115                 120                 125             
Tyr Ala Ile Phe Leu Thr Lys Lys Phe Ser Arg Arg His Gly Pro Thr 
    130                 135                 140                 
Ile Thr Ala Lys Leu Tyr Gly Arg Ala Pro Gln Leu Arg Glu Thr Leu 
145                 150                 155                 160 
Leu Gln Asp Phe Arg Val Val Ala Gln Gly Val Gly Ile Pro Glu Asp 
                165                 170                 175     
Ser Ile Phe Thr Met Ala Asp Arg Gly Glu Cys Val Pro Gly Glu Gln 
            180                 185                 190         
Glu Pro Glu Pro Ile Leu Ile Pro Arg 
        195                 200     

<210> 34
<211> 201
<212> PRT
<213> Homo sapiens

<220> 
<223> 11. M8H5GIEGR-Human P35K

<400> 34
Met His His His His His His His His Gly Gly Gly Gly Gly Ile Glu 
1               5                   10                  15      
Gly Arg Gly Pro Val Pro Thr Pro Pro Asp Asn Ile Gln Val Gln Glu 
            20                  25                  30          
Asn Phe Asn Ile Ser Arg Ile Tyr Gly Lys Trp Tyr Asn Leu Ala Ile 
        35                  40                  45              
Gly Ser Thr Cys Lys Trp Leu Lys Lys Ile Met Asp Arg Met Thr Val 
    50                  55                  60                  
Ser Thr Leu Val Leu Gly Glu Gly Ala Thr Glu Ala Glu Ile Ser Met 
65                  70                  75                  80  
Thr Ser Thr Arg Trp Arg Lys Gly Val Cys Glu Glu Thr Ser Gly Ala 
                85                  90                  95      
Tyr Glu Lys Thr Asp Thr Asp Gly Lys Phe Leu Tyr His Lys Ser Lys 
            100                 105                 110         
Trp Asn Ile Thr Met Glu Ser Tyr Val Val His Thr Asn Tyr Asp Glu 
        115                 120                 125             
Tyr Ala Ile Phe Leu Thr Lys Lys Phe Ser Arg His His Gly Pro Thr 
    130                 135                 140                 
Ile Thr Ala Lys Leu Tyr Gly Arg Ala Pro Gln Leu Arg Glu Thr Leu 
145                 150                 155                 160 
Leu Gln Asp Phe Arg Val Val Ala Gln Gly Val Gly Ile Pro Glu Asp 
                165                 170                 175     
Ser Ile Phe Thr Met Ala Asp Arg Gly Glu Cys Val Pro Gly Glu Gln 
            180                 185                 190         
Glu Pro Glu Pro Ile Leu Ile Pro Arg 
        195                 200     

<210> 35
<211> 201
<212> PRT
<213> Homo sapiens

<220> 
<223> 12. M8H5GIEGR-Human M41K

<400> 35
Met His His His His His His His His Gly Gly Gly Gly Gly Ile Glu 
1               5                   10                  15      
Gly Arg Gly Pro Val Pro Thr Pro Pro Asp Asn Ile Gln Val Gln Glu 
            20                  25                  30          
Asn Phe Asn Ile Ser Arg Ile Tyr Gly Lys Trp Tyr Asn Leu Ala Ile 
        35                  40                  45              
Gly Ser Thr Cys Pro Trp Leu Lys Lys Ile Lys Asp Arg Met Thr Val 
    50                  55                  60                  
Ser Thr Leu Val Leu Gly Glu Gly Ala Thr Glu Ala Glu Ile Ser Met 
65                  70                  75                  80  
Thr Ser Thr Arg Trp Arg Lys Gly Val Cys Glu Glu Thr Ser Gly Ala 
                85                  90                  95      
Tyr Glu Lys Thr Asp Thr Asp Gly Lys Phe Leu Tyr His Lys Ser Lys 
            100                 105                 110         
Trp Asn Ile Thr Met Glu Ser Tyr Val Val His Thr Asn Tyr Asp Glu 
        115                 120                 125             
Tyr Ala Ile Phe Leu Thr Lys Lys Phe Ser Arg His His Gly Pro Thr 
    130                 135                 140                 
Ile Thr Ala Lys Leu Tyr Gly Arg Ala Pro Gln Leu Arg Glu Thr Leu 
145                 150                 155                 160 
Leu Gln Asp Phe Arg Val Val Ala Gln Gly Val Gly Ile Pro Glu Asp 
                165                 170                 175     
Ser Ile Phe Thr Met Ala Asp Arg Gly Glu Cys Val Pro Gly Glu Gln 
            180                 185                 190         
Glu Pro Glu Pro Ile Leu Ile Pro Arg 
        195                 200     

<210> 36
<211> 201
<212> PRT
<213> Homo sapiens

<220> 
<223> 13. M8H5GIEGR-Human R66H

<400> 36
Met His His His His His His His His Gly Gly Gly Gly Gly Ile Glu 
1               5                   10                  15      
Gly Arg Gly Pro Val Pro Thr Pro Pro Asp Asn Ile Gln Val Gln Glu 
            20                  25                  30          
Asn Phe Asn Ile Ser Arg Ile Tyr Gly Lys Trp Tyr Asn Leu Ala Ile 
        35                  40                  45              
Gly Ser Thr Cys Pro Trp Leu Lys Lys Ile Met Asp Arg Met Thr Val 
    50                  55                  60                  
Ser Thr Leu Val Leu Gly Glu Gly Ala Thr Glu Ala Glu Ile Ser Met 
65                  70                  75                  80  
Thr Ser Thr His Trp Arg Lys Gly Val Cys Glu Glu Thr Ser Gly Ala 
                85                  90                  95      
Tyr Glu Lys Thr Asp Thr Asp Gly Lys Phe Leu Tyr His Lys Ser Lys 
            100                 105                 110         
Trp Asn Ile Thr Met Glu Ser Tyr Val Val His Thr Asn Tyr Asp Glu 
        115                 120                 125             
Tyr Ala Ile Phe Leu Thr Lys Lys Phe Ser Arg His His Gly Pro Thr 
    130                 135                 140                 
Ile Thr Ala Lys Leu Tyr Gly Arg Ala Pro Gln Leu Arg Glu Thr Leu 
145                 150                 155                 160 
Leu Gln Asp Phe Arg Val Val Ala Gln Gly Val Gly Ile Pro Glu Asp 
                165                 170                 175     
Ser Ile Phe Thr Met Ala Asp Arg Gly Glu Cys Val Pro Gly Glu Gln 
            180                 185                 190         
Glu Pro Glu Pro Ile Leu Ile Pro Arg 
        195                 200     

<210> 37
<211> 201
<212> PRT
<213> Homo sapiens

<220> 
<223> 14. M8H5GIEGR-Human T75K

<400> 37
Met His His His His His His His His Gly Gly Gly Gly Gly Ile Glu 
1               5                   10                  15      
Gly Arg Gly Pro Val Pro Thr Pro Pro Asp Asn Ile Gln Val Gln Glu 
            20                  25                  30          
Asn Phe Asn Ile Ser Arg Ile Tyr Gly Lys Trp Tyr Asn Leu Ala Ile 
        35                  40                  45              
Gly Ser Thr Cys Pro Trp Leu Lys Lys Ile Met Asp Arg Met Thr Val 
    50                  55                  60                  
Ser Thr Leu Val Leu Gly Glu Gly Ala Thr Glu Ala Glu Ile Ser Met 
65                  70                  75                  80  
Thr Ser Thr Arg Trp Arg Lys Gly Val Cys Glu Glu Lys Ser Gly Ala 
                85                  90                  95      
Tyr Glu Lys Thr Asp Thr Asp Gly Lys Phe Leu Tyr His Lys Ser Lys 
            100                 105                 110         
Trp Asn Ile Thr Met Glu Ser Tyr Val Val His Thr Asn Tyr Asp Glu 
        115                 120                 125             
Tyr Ala Ile Phe Leu Thr Lys Lys Phe Ser Arg His His Gly Pro Thr 
    130                 135                 140                 
Ile Thr Ala Lys Leu Tyr Gly Arg Ala Pro Gln Leu Arg Glu Thr Leu 
145                 150                 155                 160 
Leu Gln Asp Phe Arg Val Val Ala Gln Gly Val Gly Ile Pro Glu Asp 
                165                 170                 175     
Ser Ile Phe Thr Met Ala Asp Arg Gly Glu Cys Val Pro Gly Glu Gln 
            180                 185                 190         
Glu Pro Glu Pro Ile Leu Ile Pro Arg 
        195                 200     

<210> 38
<211> 201
<212> PRT
<213> Homo sapiens

<220> 
<223> 15. M8H5GIEGR-Human T75Y

<400> 38
Met His His His His His His His His Gly Gly Gly Gly Gly Ile Glu 
1               5                   10                  15      
Gly Arg Gly Pro Val Pro Thr Pro Pro Asp Asn Ile Gln Val Gln Glu 
            20                  25                  30          
Asn Phe Asn Ile Ser Arg Ile Tyr Gly Lys Trp Tyr Asn Leu Ala Ile 
        35                  40                  45              
Gly Ser Thr Cys Pro Trp Leu Lys Lys Ile Met Asp Arg Met Thr Val 
    50                  55                  60                  
Ser Thr Leu Val Leu Gly Glu Gly Ala Thr Glu Ala Glu Ile Ser Met 
65                  70                  75                  80  
Thr Ser Thr Arg Trp Arg Lys Gly Val Cys Glu Glu Tyr Ser Gly Ala 
                85                  90                  95      
Tyr Glu Lys Thr Asp Thr Asp Gly Lys Phe Leu Tyr His Lys Ser Lys 
            100                 105                 110         
Trp Asn Ile Thr Met Glu Ser Tyr Val Val His Thr Asn Tyr Asp Glu 
        115                 120                 125             
Tyr Ala Ile Phe Leu Thr Lys Lys Phe Ser Arg His His Gly Pro Thr 
    130                 135                 140                 
Ile Thr Ala Lys Leu Tyr Gly Arg Ala Pro Gln Leu Arg Glu Thr Leu 
145                 150                 155                 160 
Leu Gln Asp Phe Arg Val Val Ala Gln Gly Val Gly Ile Pro Glu Asp 
                165                 170                 175     
Ser Ile Phe Thr Met Ala Asp Arg Gly Glu Cys Val Pro Gly Glu Gln 
            180                 185                 190         
Glu Pro Glu Pro Ile Leu Ile Pro Arg 
        195                 200     

<210> 39
<211> 201
<212> PRT
<213> Homo sapiens

<220> 
<223> 16. M8H5GIEGR-Human M99K

<400> 39
Met His His His His His His His His Gly Gly Gly Gly Gly Ile Glu 
1               5                   10                  15      
Gly Arg Gly Pro Val Pro Thr Pro Pro Asp Asn Ile Gln Val Gln Glu 
            20                  25                  30          
Asn Phe Asn Ile Ser Arg Ile Tyr Gly Lys Trp Tyr Asn Leu Ala Ile 
        35                  40                  45              
Gly Ser Thr Cys Pro Trp Leu Lys Lys Ile Met Asp Arg Met Thr Val 
    50                  55                  60                  
Ser Thr Leu Val Leu Gly Glu Gly Ala Thr Glu Ala Glu Ile Ser Met 
65                  70                  75                  80  
Thr Ser Thr Arg Trp Arg Lys Gly Val Cys Glu Glu Thr Ser Gly Ala 
                85                  90                  95      
Tyr Glu Lys Thr Asp Thr Asp Gly Lys Phe Leu Tyr His Lys Ser Lys 
            100                 105                 110         
Trp Asn Ile Thr Lys Glu Ser Tyr Val Val His Thr Asn Tyr Asp Glu 
        115                 120                 125             
Tyr Ala Ile Phe Leu Thr Lys Lys Phe Ser Arg His His Gly Pro Thr 
    130                 135                 140                 
Ile Thr Ala Lys Leu Tyr Gly Arg Ala Pro Gln Leu Arg Glu Thr Leu 
145                 150                 155                 160 
Leu Gln Asp Phe Arg Val Val Ala Gln Gly Val Gly Ile Pro Glu Asp 
                165                 170                 175     
Ser Ile Phe Thr Met Ala Asp Arg Gly Glu Cys Val Pro Gly Glu Gln 
            180                 185                 190         
Glu Pro Glu Pro Ile Leu Ile Pro Arg 
        195                 200     

<210> 40
<211> 201
<212> PRT
<213> Homo sapiens

<220> 
<223> 17. M8H5GIEGR-Human S101Y

<400> 40
Met His His His His His His His His Gly Gly Gly Gly Gly Ile Glu 
1               5                   10                  15      
Gly Arg Gly Pro Val Pro Thr Pro Pro Asp Asn Ile Gln Val Gln Glu 
            20                  25                  30          
Asn Phe Asn Ile Ser Arg Ile Tyr Gly Lys Trp Tyr Asn Leu Ala Ile 
        35                  40                  45              
Gly Ser Thr Cys Pro Trp Leu Lys Lys Ile Met Asp Arg Met Thr Val 
    50                  55                  60                  
Ser Thr Leu Val Leu Gly Glu Gly Ala Thr Glu Ala Glu Ile Ser Met 
65                  70                  75                  80  
Thr Ser Thr Arg Trp Arg Lys Gly Val Cys Glu Glu Thr Ser Gly Ala 
                85                  90                  95      
Tyr Glu Lys Thr Asp Thr Asp Gly Lys Phe Leu Tyr His Lys Ser Lys 
            100                 105                 110         
Trp Asn Ile Thr Met Glu Tyr Tyr Val Val His Thr Asn Tyr Asp Glu 
        115                 120                 125             
Tyr Ala Ile Phe Leu Thr Lys Lys Phe Ser Arg His His Gly Pro Thr 
    130                 135                 140                 
Ile Thr Ala Lys Leu Tyr Gly Arg Ala Pro Gln Leu Arg Glu Thr Leu 
145                 150                 155                 160 
Leu Gln Asp Phe Arg Val Val Ala Gln Gly Val Gly Ile Pro Glu Asp 
                165                 170                 175     
Ser Ile Phe Thr Met Ala Asp Arg Gly Glu Cys Val Pro Gly Glu Gln 
            180                 185                 190         
Glu Pro Glu Pro Ile Leu Ile Pro Arg 
        195                 200     

<210> 41
<211> 201
<212> PRT
<213> Homo sapiens

<220> 
<223> 18. M8H5GIEGR-Human K69.92.118.130R

<400> 41
Met His His His His His His His His Gly Gly Gly Gly Gly Ile Glu 
1               5                   10                  15      
Gly Arg Gly Pro Val Pro Thr Pro Pro Asp Asn Ile Gln Val Gln Glu 
            20                  25                  30          
Asn Phe Asn Ile Ser Arg Ile Tyr Gly Lys Trp Tyr Asn Leu Ala Ile 
        35                  40                  45              
Gly Ser Thr Cys Pro Trp Leu Lys Lys Ile Met Asp Arg Met Thr Val 
    50                  55                  60                  
Ser Thr Leu Val Leu Gly Glu Gly Ala Thr Glu Ala Glu Ile Ser Met 
65                  70                  75                  80  
Thr Ser Thr Arg Trp Arg Arg Gly Val Cys Glu Glu Thr Ser Gly Ala 
                85                  90                  95      
Tyr Glu Lys Thr Asp Thr Asp Gly Lys Phe Leu Tyr His Arg Ser Lys 
            100                 105                 110         
Trp Asn Ile Thr Met Glu Ser Tyr Val Val His Thr Asn Tyr Asp Glu 
        115                 120                 125             
Tyr Ala Ile Phe Leu Thr Lys Arg Phe Ser Arg His His Gly Pro Thr 
    130                 135                 140                 
Ile Thr Ala Arg Leu Tyr Gly Arg Ala Pro Gln Leu Arg Glu Thr Leu 
145                 150                 155                 160 
Leu Gln Asp Phe Arg Val Val Ala Gln Gly Val Gly Ile Pro Glu Asp 
                165                 170                 175     
Ser Ile Phe Thr Met Ala Asp Arg Gly Glu Cys Val Pro Gly Glu Gln 
            180                 185                 190         
Glu Pro Glu Pro Ile Leu Ile Pro Arg 
        195                 200     

<210> 42
<211> 198
<212> PRT
<213> Latimeria

<220> 
<223> 19. M8H5GIEGR-Coelacanth

<400> 42
Met His His His His His His His His Gly Gly Gly Gly Gly Ile Glu 
1               5                   10                  15      
Gly Arg Gly Ser Pro Leu Arg Asp Glu Asp Ile Gln Val Gln Glu Asn 
            20                  25                  30          
Phe Asp Leu Pro Arg Ile Tyr Gly Lys Trp Tyr Glu Ile Ala Ile Ala 
        35                  40                  45              
Ser Thr Cys Pro Trp Val Lys Asn His Lys Asp Lys Met Phe Met Gly 
    50                  55                  60                  
Thr Met Val Leu Gln Glu Gly Glu Gln Ser Asp Arg Ile Ser Thr Thr 
65                  70                  75                  80  
Ser Thr Arg Ile Arg Asp Gly Thr Cys Ser Gln Ile Thr Gly Tyr Tyr 
                85                  90                  95      
Thr Leu Thr Thr Thr Pro Gly Lys Phe Ala Tyr His Asn Ser Lys Trp 
            100                 105                 110         
Asn Leu Asp Val Asn Ser Tyr Val Val His Thr Asn Tyr Asp Glu Tyr 
        115                 120                 125             
Ser Ile Val Met Met Gln Lys Tyr Lys Ser Ser Asn Ser Thr Thr Thr 
    130                 135                 140                 
Val Arg Leu Tyr Gly Arg Thr Gln Glu Leu Arg Asp Ser Leu His Ala 
145                 150                 155                 160 
Glu Phe Lys Lys Phe Ala Leu Asp Gln Gly Ile Asp Glu Asp Ser Ile 
                165                 170                 175     
Tyr Ile Leu Pro Lys Arg Asp Glu Cys Val Pro Gly Glu Pro Lys Ala 
            180                 185                 190         
Glu Ser Leu Met Ala Arg 
        195             

<210> 43
<211> 201
<212> PRT
<213> Homo sapiens

<220> 
<223> 21. M8H5GIEGR-Human L89T

<400> 43
Met His His His His His His His His Gly Gly Gly Gly Gly Ile Glu 
1               5                   10                  15      
Gly Arg Gly Pro Val Pro Thr Pro Pro Asp Asn Ile Gln Val Gln Glu 
            20                  25                  30          
Asn Phe Asn Ile Ser Arg Ile Tyr Gly Lys Trp Tyr Asn Leu Ala Ile 
        35                  40                  45              
Gly Ser Thr Cys Pro Trp Leu Lys Lys Ile Met Asp Arg Met Thr Val 
    50                  55                  60                  
Ser Thr Leu Val Leu Gly Glu Gly Ala Thr Glu Ala Glu Ile Ser Met 
65                  70                  75                  80  
Thr Ser Thr Arg Trp Arg Lys Gly Val Cys Glu Glu Thr Ser Gly Ala 
                85                  90                  95      
Tyr Glu Lys Thr Asp Thr Asp Gly Lys Phe Thr Tyr His Lys Ser Lys 
            100                 105                 110         
Trp Asn Ile Thr Met Glu Ser Tyr Val Val His Thr Asn Tyr Asp Glu 
        115                 120                 125             
Tyr Ala Ile Phe Leu Thr Lys Lys Phe Ser Arg His His Gly Pro Thr 
    130                 135                 140                 
Ile Thr Ala Lys Leu Tyr Gly Arg Ala Pro Gln Leu Arg Glu Thr Leu 
145                 150                 155                 160 
Leu Gln Asp Phe Arg Val Val Ala Gln Gly Val Gly Ile Pro Glu Asp 
                165                 170                 175     
Ser Ile Phe Thr Met Ala Asp Arg Gly Glu Cys Val Pro Gly Glu Gln 
            180                 185                 190         
Glu Pro Glu Pro Ile Leu Ile Pro Arg 
        195                 200     

<210> 44
<211> 201
<212> PRT
<213> Homo sapiens

<220> 
<223> 22. M8H5GIEGR-Human N1796D

<400> 44
Met His His His His His His His His Gly Gly Gly Gly Gly Ile Glu 
1               5                   10                  15      
Gly Arg Gly Pro Val Pro Thr Pro Pro Asp Asn Ile Gln Val Gln Glu 
            20                  25                  30          
Asn Phe Asp Ile Ser Arg Ile Tyr Gly Lys Trp Tyr Asn Leu Ala Ile 
        35                  40                  45              
Gly Ser Thr Cys Pro Trp Leu Lys Lys Ile Met Asp Arg Met Thr Val 
    50                  55                  60                  
Ser Thr Leu Val Leu Gly Glu Gly Ala Thr Glu Ala Glu Ile Ser Met 
65                  70                  75                  80  
Thr Ser Thr Arg Trp Arg Lys Gly Val Cys Glu Glu Thr Ser Gly Ala 
                85                  90                  95      
Tyr Glu Lys Thr Asp Thr Asp Gly Lys Phe Leu Tyr His Lys Ser Lys 
            100                 105                 110         
Trp Asp Ile Thr Met Glu Ser Tyr Val Val His Thr Asn Tyr Asp Glu 
        115                 120                 125             
Tyr Ala Ile Phe Leu Thr Lys Lys Phe Ser Arg His His Gly Pro Thr 
    130                 135                 140                 
Ile Thr Ala Lys Leu Tyr Gly Arg Ala Pro Gln Leu Arg Glu Thr Leu 
145                 150                 155                 160 
Leu Gln Asp Phe Arg Val Val Ala Gln Gly Val Gly Ile Pro Glu Asp 
                165                 170                 175     
Ser Ile Phe Thr Met Ala Asp Arg Gly Glu Cys Val Pro Gly Glu Gln 
            180                 185                 190         
Glu Pro Glu Pro Ile Leu Ile Pro Arg 
        195                 200     

<210> 45
<211> 201
<212> PRT
<213> Homo sapiens

<220> 
<223> 23. M8H5GIEGR-Human T45K

<400> 45
Met His His His His His His His His Gly Gly Gly Gly Gly Ile Glu 
1               5                   10                  15      
Gly Arg Gly Pro Val Pro Thr Pro Pro Asp Asn Ile Gln Val Gln Glu 
            20                  25                  30          
Asn Phe Asn Ile Ser Arg Ile Tyr Gly Lys Trp Tyr Asn Leu Ala Ile 
        35                  40                  45              
Gly Ser Thr Cys Pro Trp Leu Lys Lys Ile Met Asp Arg Met Lys Val 
    50                  55                  60                  
Ser Thr Leu Val Leu Gly Glu Gly Ala Thr Glu Ala Glu Ile Ser Met 
65                  70                  75                  80  
Thr Ser Thr Arg Trp Arg Lys Gly Val Cys Glu Glu Thr Ser Gly Ala 
                85                  90                  95      
Tyr Glu Lys Thr Asp Thr Asp Gly Lys Phe Leu Tyr His Lys Ser Lys 
            100                 105                 110         
Trp Asn Ile Thr Met Glu Ser Tyr Val Val His Thr Asn Tyr Asp Glu 
        115                 120                 125             
Tyr Ala Ile Phe Leu Thr Lys Lys Phe Ser Arg His His Gly Pro Thr 
    130                 135                 140                 
Ile Thr Ala Lys Leu Tyr Gly Arg Ala Pro Gln Leu Arg Glu Thr Leu 
145                 150                 155                 160 
Leu Gln Asp Phe Arg Val Val Ala Gln Gly Val Gly Ile Pro Glu Asp 
                165                 170                 175     
Ser Ile Phe Thr Met Ala Asp Arg Gly Glu Cys Val Pro Gly Glu Gln 
            180                 185                 190         
Glu Pro Glu Pro Ile Leu Ile Pro Arg 
        195                 200     

<210> 46
<211> 201
<212> PRT
<213> Homo sapiens

<220> 
<223> 24. M8H5GIEGR-Human A135E

<400> 46
Met His His His His His His His His Gly Gly Gly Gly Gly Ile Glu 
1               5                   10                  15      
Gly Arg Gly Pro Val Pro Thr Pro Pro Asp Asn Ile Gln Val Gln Glu 
            20                  25                  30          
Asn Phe Asn Ile Ser Arg Ile Tyr Gly Lys Trp Tyr Asn Leu Ala Ile 
        35                  40                  45              
Gly Ser Thr Cys Pro Trp Leu Lys Lys Ile Met Asp Arg Met Thr Val 
    50                  55                  60                  
Ser Thr Leu Val Leu Gly Glu Gly Ala Thr Glu Ala Glu Ile Ser Met 
65                  70                  75                  80  
Thr Ser Thr Arg Trp Arg Lys Gly Val Cys Glu Glu Thr Ser Gly Ala 
                85                  90                  95      
Tyr Glu Lys Thr Asp Thr Asp Gly Lys Phe Leu Tyr His Lys Ser Lys 
            100                 105                 110         
Trp Asn Ile Thr Met Glu Ser Tyr Val Val His Thr Asn Tyr Asp Glu 
        115                 120                 125             
Tyr Ala Ile Phe Leu Thr Lys Lys Phe Ser Arg His His Gly Pro Thr 
    130                 135                 140                 
Ile Thr Ala Lys Leu Tyr Gly Arg Glu Pro Gln Leu Arg Glu Thr Leu 
145                 150                 155                 160 
Leu Gln Asp Phe Arg Val Val Ala Gln Gly Val Gly Ile Pro Glu Asp 
                165                 170                 175     
Ser Ile Phe Thr Met Ala Asp Arg Gly Glu Cys Val Pro Gly Glu Gln 
            180                 185                 190         
Glu Pro Glu Pro Ile Leu Ile Pro Arg 
        195                 200     

<210> 47
<211> 201
<212> PRT
<213> Homo sapiens

<220> 
<223> 25. M8H5GIEGR-Human V170S

<400> 47
Met His His His His His His His His Gly Gly Gly Gly Gly Ile Glu 
1               5                   10                  15      
Gly Arg Gly Pro Val Pro Thr Pro Pro Asp Asn Ile Gln Val Gln Glu 
            20                  25                  30          
Asn Phe Asn Ile Ser Arg Ile Tyr Gly Lys Trp Tyr Asn Leu Ala Ile 
        35                  40                  45              
Gly Ser Thr Cys Pro Trp Leu Lys Lys Ile Met Asp Arg Met Thr Val 
    50                  55                  60                  
Ser Thr Leu Val Leu Gly Glu Gly Ala Thr Glu Ala Glu Ile Ser Met 
65                  70                  75                  80  
Thr Ser Thr Arg Trp Arg Lys Gly Val Cys Glu Glu Thr Ser Gly Ala 
                85                  90                  95      
Tyr Glu Lys Thr Asp Thr Asp Gly Lys Phe Leu Tyr His Lys Ser Lys 
            100                 105                 110         
Trp Asn Ile Thr Met Glu Ser Tyr Val Val His Thr Asn Tyr Asp Glu 
        115                 120                 125             
Tyr Ala Ile Phe Leu Thr Lys Lys Phe Ser Arg His His Gly Pro Thr 
    130                 135                 140                 
Ile Thr Ala Lys Leu Tyr Gly Arg Ala Pro Gln Leu Arg Glu Thr Leu 
145                 150                 155                 160 
Leu Gln Asp Phe Arg Val Val Ala Gln Gly Val Gly Ile Pro Glu Asp 
                165                 170                 175     
Ser Ile Phe Thr Met Ala Asp Arg Gly Glu Cys Ser Pro Gly Glu Gln 
            180                 185                 190         
Glu Pro Glu Pro Ile Leu Ile Pro Arg 
        195                 200     

<210> 48
<211> 201
<212> PRT
<213> Homo sapiens

<220> 
<223> 26. M8H5GIEGR-Human

<400> 48
Met His His His His His His His His Gly Gly Gly Gly Gly Ile Glu 
1               5                   10                  15      
Gly Arg Gly Pro Val Pro Thr Pro Pro Asp Asn Ile Gln Val Gln Glu 
            20                  25                  30          
Asn Phe Asn Ile Ser Arg Ile Tyr Gly Lys Trp Tyr Asn Leu Ala Ile 
        35                  40                  45              
Gly Ser Thr Cys Pro Trp Leu Lys Lys Ile Met Asp Arg Met Thr Val 
    50                  55                  60                  
Ser Thr Leu Val Leu Gly Glu Gly Ala Thr Glu Ala Glu Ile Ser Met 
65                  70                  75                  80  
Thr Ser Thr Arg Trp Arg Lys Gly Val Cys Glu Glu Thr Ser Gly Ala 
                85                  90                  95      
Tyr Glu Lys Thr Asp Thr Asp Gly Lys Phe Leu Tyr His Lys Ser Lys 
            100                 105                 110         
Trp Asn Ile Thr Met Glu Ser Tyr Val Val His Thr Asn Tyr Asp Glu 
        115                 120                 125             
Tyr Ala Ile Phe Leu Thr Lys Lys Phe Ser Arg His His Gly Pro Thr 
    130                 135                 140                 
Ile Thr Ala Lys Leu Tyr Gly Arg Ala Pro Gln Leu Arg Glu Thr Leu 
145                 150                 155                 160 
Leu Gln Asp Phe Arg Asp Val Ala Gln Gly Val Gly Ile Pro Glu Asp 
                165                 170                 175     
Ser Ile Phe Thr Met Ala Asp Arg Gly Glu Cys Val Pro Gly Glu Gln 
            180                 185                 190         
Glu Pro Glu Pro Ile Leu Ile Pro Arg 
        195                 200     

<210> 49
<211> 201
<212> PRT
<213> Homo sapiens

<220> 
<223> 27. M8H5GIEGR-Human G172Q

<400> 49
Met His His His His His His His His Gly Gly Gly Gly Gly Ile Glu 
1               5                   10                  15      
Gly Arg Gly Pro Val Pro Thr Pro Pro Asp Asn Ile Gln Val Gln Glu 
            20                  25                  30          
Asn Phe Asn Ile Ser Arg Ile Tyr Gly Lys Trp Tyr Asn Leu Ala Ile 
        35                  40                  45              
Gly Ser Thr Cys Pro Trp Leu Lys Lys Ile Met Asp Arg Met Thr Val 
    50                  55                  60                  
Ser Thr Leu Val Leu Gly Glu Gly Ala Thr Glu Ala Glu Ile Ser Met 
65                  70                  75                  80  
Thr Ser Thr Arg Trp Arg Lys Gly Val Cys Glu Glu Thr Ser Gly Ala 
                85                  90                  95      
Tyr Glu Lys Thr Asp Thr Asp Gly Lys Phe Leu Tyr His Lys Ser Lys 
            100                 105                 110         
Trp Asn Ile Thr Met Glu Ser Tyr Val Val His Thr Asn Tyr Asp Glu 
        115                 120                 125             
Tyr Ala Ile Phe Leu Thr Lys Lys Phe Ser Arg His His Gly Pro Thr 
    130                 135                 140                 
Ile Thr Ala Lys Leu Tyr Gly Arg Ala Pro Gln Leu Arg Glu Thr Leu 
145                 150                 155                 160 
Leu Gln Asp Phe Arg Val Val Ala Gln Gly Val Gly Ile Pro Glu Asp 
                165                 170                 175     
Ser Ile Phe Thr Met Ala Asp Arg Gly Glu Cys Val Pro Gln Glu Gln 
            180                 185                 190         
Glu Pro Glu Pro Ile Leu Ile Pro Arg 
        195                 200     

<210> 50
<211> 197
<212> PRT
<213> Homo sapiens

<220> 
<223> 33. M8H4DK-Human M41K+

<400> 50
Met His His His His His His His His Asp Asp Asp Asp Lys Gly Pro 
1               5                   10                  15      
Val Pro Thr Pro Pro Asp Asn Ile Gln Val Gln Glu Asn Phe Asn Ile 
            20                  25                  30          
Ser Arg Ile Tyr Gly Lys Trp Tyr Asn Leu Ala Ile Gly Ser Thr Cys 
        35                  40                  45              
Pro Trp Leu Lys Lys Ile Lys Asp Arg Met Thr Val Ser Thr Leu Val 
    50                  55                  60                  
Leu Gly Glu Gly Ala Thr Glu Ala Glu Ile Ser Met Thr Ser Thr His 
65                  70                  75                  80  
Trp Arg Lys Gly Val Cys Glu Glu Thr Ser Gly Ala Tyr Glu Lys Thr 
                85                  90                  95      
Asp Thr Asp Gly Lys Phe Leu Tyr His Lys Ser Lys Trp Asn Ile Thr 
            100                 105                 110         
Met Glu Ser Tyr Val Val His Thr Asn Tyr Asp Glu Tyr Ala Ile Phe 
        115                 120                 125             
Leu Thr Lys Lys Phe Ser Arg His His Gly Pro Thr Ile Thr Ala Lys 
    130                 135                 140                 
Leu Tyr Gly Arg Ala Pro Gln Leu Arg Glu Thr Leu Leu Gln Asp Phe 
145                 150                 155                 160 
Arg Val Val Ala Gln Gly Val Gly Ile Pro Glu Asp Ser Ile Phe Thr 
                165                 170                 175     
Met Ala Asp Arg Gly Glu Cys Val Pro Gly Glu Gln Glu Pro Glu Pro 
            180                 185                 190         
Ile Leu Ile Pro Arg 
        195         

<210> 51
<211> 197
<212> PRT
<213> Homo sapiens

<220> 
<223> 34. M8H4DK-Human M41K+N1796D 34

<400> 51
Met His His His His His His His His Asp Asp Asp Asp Lys Gly Pro 
1               5                   10                  15      
Val Pro Thr Pro Pro Asp Asn Ile Gln Val Gln Glu Asn Phe Asp Ile 
            20                  25                  30          
Ser Arg Ile Tyr Gly Lys Trp Tyr Asn Leu Ala Ile Gly Ser Thr Cys 
        35                  40                  45              
Pro Trp Leu Lys Lys Ile Lys Asp Arg Met Thr Val Ser Thr Leu Val 
    50                  55                  60                  
Leu Gly Glu Gly Ala Thr Glu Ala Glu Ile Ser Met Thr Ser Thr Arg 
65                  70                  75                  80  
Trp Arg Lys Gly Val Cys Glu Glu Thr Ser Gly Ala Tyr Glu Lys Thr 
                85                  90                  95      
Asp Thr Asp Gly Lys Phe Leu Tyr His Lys Ser Lys Trp Asp Ile Thr 
            100                 105                 110         
Met Glu Ser Tyr Val Val His Thr Asn Tyr Asp Glu Tyr Ala Ile Phe 
        115                 120                 125             
Leu Thr Lys Lys Phe Ser Arg His His Gly Pro Thr Ile Thr Ala Lys 
    130                 135                 140                 
Leu Tyr Gly Arg Ala Pro Gln Leu Arg Glu Thr Leu Leu Gln Asp Phe 
145                 150                 155                 160 
Arg Val Val Ala Gln Gly Val Gly Ile Pro Glu Asp Ser Ile Phe Thr 
                165                 170                 175     
Met Ala Asp Arg Gly Glu Cys Val Pro Gly Glu Gln Glu Pro Glu Pro 
            180                 185                 190         
Ile Leu Ile Pro Arg 
        195         

<210> 52
<211> 197
<212> PRT
<213> Homo sapiens

<220> 
<223> 35. M8H4DK-Human R66H+N1796D

<400> 52
Met His His His His His His His His Asp Asp Asp Asp Lys Gly Pro 
1               5                   10                  15      
Val Pro Thr Pro Pro Asp Asn Ile Gln Val Gln Glu Asn Phe Asp Ile 
            20                  25                  30          
Ser Arg Ile Tyr Gly Lys Trp Tyr Asn Leu Ala Ile Gly Ser Thr Cys 
        35                  40                  45              
Pro Trp Leu Lys Lys Ile Met Asp Arg Met Thr Val Ser Thr Leu Val 
    50                  55                  60                  
Leu Gly Glu Gly Ala Thr Glu Ala Glu Ile Ser Met Thr Ser Thr His 
65                  70                  75                  80  
Trp Arg Lys Gly Val Cys Glu Glu Thr Ser Gly Ala Tyr Glu Lys Thr 
                85                  90                  95      
Asp Thr Asp Gly Lys Phe Leu Tyr His Lys Ser Lys Trp Asp Ile Thr 
            100                 105                 110         
Met Glu Ser Tyr Val Val His Thr Asn Tyr Asp Glu Tyr Ala Ile Phe 
        115                 120                 125             
Leu Thr Lys Lys Phe Ser Arg His His Gly Pro Thr Ile Thr Ala Lys 
    130                 135                 140                 
Leu Tyr Gly Arg Ala Pro Gln Leu Arg Glu Thr Leu Leu Gln Asp Phe 
145                 150                 155                 160 
Arg Val Val Ala Gln Gly Val Gly Ile Pro Glu Asp Ser Ile Phe Thr 
                165                 170                 175     
Met Ala Asp Arg Gly Glu Cys Val Pro Gly Glu Gln Glu Pro Glu Pro 
            180                 185                 190         
Ile Leu Ile Pro Arg 
        195         

<210> 53
<211> 197
<212> PRT
<213> Homo sapiens

<220> 
<223> 36. M8H4DK-Human M41K+R66H+N1796D

<400> 53
Met His His His His His His His His Asp Asp Asp Asp Lys Gly Pro 
1               5                   10                  15      
Val Pro Thr Pro Pro Asp Asn Ile Gln Val Gln Glu Asn Phe Asp Ile 
            20                  25                  30          
Ser Arg Ile Tyr Gly Lys Trp Tyr Asn Leu Ala Ile Gly Ser Thr Cys 
        35                  40                  45              
Pro Trp Leu Lys Lys Ile Lys Asp Arg Met Thr Val Ser Thr Leu Val 
    50                  55                  60                  
Leu Gly Glu Gly Ala Thr Glu Ala Glu Ile Ser Met Thr Ser Thr His 
65                  70                  75                  80  
Trp Arg Lys Gly Val Cys Glu Glu Thr Ser Gly Ala Tyr Glu Lys Thr 
                85                  90                  95      
Asp Thr Asp Gly Lys Phe Leu Tyr His Lys Ser Lys Trp Asp Ile Thr 
            100                 105                 110         
Met Glu Ser Tyr Val Val His Thr Asn Tyr Asp Glu Tyr Ala Ile Phe 
        115                 120                 125             
Leu Thr Lys Lys Phe Ser Arg His His Gly Pro Thr Ile Thr Ala Lys 
    130                 135                 140                 
Leu Tyr Gly Arg Ala Pro Gln Leu Arg Glu Thr Leu Leu Gln Asp Phe 
145                 150                 155                 160 
Arg Val Val Ala Gln Gly Val Gly Ile Pro Glu Asp Ser Ile Phe Thr 
                165                 170                 175     
Met Ala Asp Arg Gly Glu Cys Val Pro Gly Glu Gln Glu Pro Glu Pro 
            180                 185                 190         
Ile Leu Ile Pro Arg 
        195         

<210> 54
<211> 197
<212> PRT
<213> Homo sapiens

<220> 
<223> 38. M8H4DK-Human R66H

<400> 54
Met His His His His His His His His Asp Asp Asp Asp Lys Gly Pro 
1               5                   10                  15      
Val Pro Thr Pro Pro Asp Asn Ile Gln Val Gln Glu Asn Phe Asn Ile 
            20                  25                  30          
Ser Arg Ile Tyr Gly Lys Trp Tyr Asn Leu Ala Ile Gly Ser Thr Cys 
        35                  40                  45              
Pro Trp Leu Lys Lys Ile Met Asp Arg Met Thr Val Ser Thr Leu Val 
    50                  55                  60                  
Leu Gly Glu Gly Ala Thr Glu Ala Glu Ile Ser Met Thr Ser Thr His 
65                  70                  75                  80  
Trp Arg Lys Gly Val Cys Glu Glu Thr Ser Gly Ala Tyr Glu Lys Thr 
                85                  90                  95      
Asp Thr Asp Gly Lys Phe Leu Tyr His Lys Ser Lys Trp Asn Ile Thr 
            100                 105                 110         
Met Glu Ser Tyr Val Val His Thr Asn Tyr Asp Glu Tyr Ala Ile Phe 
        115                 120                 125             
Leu Thr Lys Lys Phe Ser Arg His His Gly Pro Thr Ile Thr Ala Lys 
    130                 135                 140                 
Leu Tyr Gly Arg Ala Pro Gln Leu Arg Glu Thr Leu Leu Gln Asp Phe 
145                 150                 155                 160 
Arg Val Val Ala Gln Gly Val Gly Ile Pro Glu Asp Ser Ile Phe Thr 
                165                 170                 175     
Met Ala Asp Arg Gly Glu Cys Val Pro Gly Glu Gln Glu Pro Glu Pro 
            180                 185                 190         
Ile Leu Ile Pro Arg 
        195         

<210> 55
<211> 197
<212> PRT
<213> Homo sapiens

<220> 
<223> 39.M8H4DK-Human

<400> 55
Met His His His His His His His His Asp Asp Asp Asp Lys Gly Pro 
1               5                   10                  15      
Val Pro Thr Pro Pro Asp Asn Ile Gln Val Gln Glu Asn Phe Asp Ile 
            20                  25                  30          
Ser Arg Ile Tyr Gly Lys Trp Tyr Asn Leu Ala Ile Gly Ser Thr Cys 
        35                  40                  45              
Pro Trp Leu Lys Lys Ile Met Asp Arg Met Thr Val Ser Thr Leu Val 
    50                  55                  60                  
Leu Gly Glu Gly Ala Thr Glu Ala Glu Ile Ser Met Thr Ser Thr Arg 
65                  70                  75                  80  
Trp Arg Lys Gly Val Cys Glu Glu Thr Ser Gly Ala Tyr Glu Lys Thr 
                85                  90                  95      
Asp Thr Asp Gly Lys Phe Leu Tyr His Lys Ser Lys Trp Asp Ile Thr 
            100                 105                 110         
Met Glu Ser Tyr Val Val His Thr Asn Tyr Asp Glu Tyr Ala Ile Phe 
        115                 120                 125             
Leu Thr Lys Lys Phe Ser Arg His His Gly Pro Thr Ile Thr Ala Lys 
    130                 135                 140                 
Leu Tyr Gly Arg Ala Pro Gln Leu Arg Glu Thr Leu Leu Gln Asp Phe 
145                 150                 155                 160 
Arg Val Val Ala Gln Gly Val Gly Ile Pro Glu Asp Ser Ile Phe Thr 
                165                 170                 175     
Met Ala Asp Arg Gly Glu Cys Val Pro Gly Glu Gln Glu Pro Glu Pro 
            180                 185                 190         
Ile Leu Ile Pro Arg 
        195         

<210> 56
<211> 192
<212> PRT
<213> Homo sapiens

<220> 
<223> 40. M8H-Human wt

<400> 56
Met His His His His His His His His Gly Pro Val Pro Thr Pro Pro 
1               5                   10                  15      
Asp Asn Ile Gln Val Gln Glu Asn Phe Asn Ile Ser Arg Ile Tyr Gly 
            20                  25                  30          
Lys Trp Tyr Asn Leu Ala Ile Gly Ser Thr Cys Pro Trp Leu Lys Lys 
        35                  40                  45              
Ile Met Asp Arg Met Thr Val Ser Thr Leu Val Leu Gly Glu Gly Ala 
    50                  55                  60                  
Thr Glu Ala Glu Ile Ser Met Thr Ser Thr Arg Trp Arg Lys Gly Val 
65                  70                  75                  80  
Cys Glu Glu Thr Ser Gly Ala Tyr Glu Lys Thr Asp Thr Asp Gly Lys 
                85                  90                  95      
Phe Leu Tyr His Lys Ser Lys Trp Asn Ile Thr Met Glu Ser Tyr Val 
            100                 105                 110         
Val His Thr Asn Tyr Asp Glu Tyr Ala Ile Phe Leu Thr Lys Lys Phe 
        115                 120                 125             
Ser Arg His His Gly Pro Thr Ile Thr Ala Lys Leu Tyr Gly Arg Ala 
    130                 135                 140                 
Pro Gln Leu Arg Glu Thr Leu Leu Gln Asp Phe Arg Val Val Ala Gln 
145                 150                 155                 160 
Gly Val Gly Ile Pro Glu Asp Ser Ile Phe Thr Met Ala Asp Arg Gly 
                165                 170                 175     
Glu Cys Val Pro Gly Glu Gln Glu Pro Glu Pro Ile Leu Ile Pro Arg 
            180                 185                 190         



<210> 57
<211> 192
<212> PRT
<213> Homo sapiens

<220> 
<223> 41. M8H-Human R66H+N1796D

<400> 57
Met His His His His His His His His Gly Pro Val Pro Thr Pro Pro 
1               5                   10                  15      
Asp Asn Ile Gln Val Gln Glu Asn Phe Asp Ile Ser Arg Ile Tyr Gly 
            20                  25                  30          
Lys Trp Tyr Asn Leu Ala Ile Gly Ser Thr Cys Pro Trp Leu Lys Lys 
        35                  40                  45              
Ile Met Asp Arg Met Thr Val Ser Thr Leu Val Leu Gly Glu Gly Ala 
    50                  55                  60                  
Thr Glu Ala Glu Ile Ser Met Thr Ser Thr His Trp Arg Lys Gly Val 
65                  70                  75                  80  
Cys Glu Glu Thr Ser Gly Ala Tyr Glu Lys Thr Asp Thr Asp Gly Lys 
                85                  90                  95      
Phe Leu Tyr His Lys Ser Lys Trp Asp Ile Thr Met Glu Ser Tyr Val 
            100                 105                 110         
Val His Thr Asn Tyr Asp Glu Tyr Ala Ile Phe Leu Thr Lys Lys Phe 
        115                 120                 125             
Ser Arg His His Gly Pro Thr Ile Thr Ala Lys Leu Tyr Gly Arg Ala 
    130                 135                 140                 
Pro Gln Leu Arg Glu Thr Leu Leu Gln Asp Phe Arg Val Val Ala Gln 
145                 150                 155                 160 
Gly Val Gly Ile Pro Glu Asp Ser Ile Phe Thr Met Ala Asp Arg Gly 
                165                 170                 175     
Glu Cys Val Pro Gly Glu Gln Glu Pro Glu Pro Ile Leu Ile Pro Arg 
            180                 185                 190         



<210> 58
<211> 594
<212> DNA
<213> Homo sapiens

<220> 
<223> 60. M8H4DK-Human wt

<400> 58
atgcatcacc atcaccatca ccatcacgat gacgatgaca agggccctgt gccaacgccg      60

cccgacaaca tccaagtgca ggaaaacttc aatatctctc ggatctatgg gaagtggtac     120

aacctggcca tcggttccac ctgcccctgg ctgaagaaga tcatggacag gatgacagtg     180

agcacgctgg tgctgggaga gggcgctaca gaggcggaga tcagcatgac cagcactcgt     240

tggcggaaag gtgtctgtga ggagacgtct ggagcttatg agaaaacaga tactgatggg     300

aagtttctct atcacaaatc caaatggaac ataaccatgg agtcctatgt ggtccacacc     360

aactatgatg agtatgccat tttcctgacc aagaaattca gccgccatca tggacccacc     420

attactgcca agctctacgg gcgggcgccg cagctgaggg aaactctcct gcaggacttc     480

agagtggttg cccagggtgt gggcatccct gaggactcca tcttcaccat ggctgaccga     540

ggtgaatgtg tccctgggga gcaggaacca gagcccatct taatcccgag atga           594


<210> 59
<211> 603
<212> DNA
<213> Mus <mouse, genus>

<220> 
<223> 1.M8H5GIEGR-Mouse

<400> 59
atgcatcacc atcaccatca ccatcacggt ggaggagggg gtatcgaggg ccgcgaccct      60

gcgtcaacac tgccagatat ccaggttcag gagaacttca gtgagtcccg gatctatgga     120

aaatggtaca acctggcggt gggatccacc tgcccgtggc tgagccgcat taaggacaag     180

atgagcgtga gcacgctggt gctgcaggag ggggcgacag aaacagagat cagcatgacc     240

agtactcgat ggcggagagg tgtctgtgag gagatcactg gggcgtacca gaagacggac     300

atcgatggaa agttcctcta ccacaaatcc aaatggaaca taaccttgga atcctatgtg     360

gtccacacca actatgacga atatgccatt ttccttacca agaagtccag ccaccaccac     420

gggctcacca tcactgccaa gctctatggt cgggagccac agctgaggga cagccttctg     480

caggagttca aggatgtggc cctgaatgtg ggcatctctg agaactccat catttttatg     540

cctgacagag gggaatgtgt ccctggggat cgggaggtgg agcccacatc aattgccaga     600

tga                                                                   603


<210> 60
<211> 606
<212> DNA
<213> Heterocephalus glaber

<220> 
<223> 2. M8H5GIEGR-Naked Mole

<400> 60
atgcatcacc atcaccatca ccatcacggt ggaggagggg gtatcgaggg ccgcaatcct      60

gtgccgatgc cgccagacaa catccaagtg caggagaact ttgatgaatc ccggatctat     120

gggaaatggt tcaacctggc tacgggctcc acgtgcccgt ggctgaagag gatcaaagac     180

aggctgagtg tgagcacaat ggtgctgggc aaggggacca cggagacaca gatcagcaca     240

acccacaccc actggcggca aggggtgtgc caggagacct caggggttta caagaaaaca     300

gacacggctg ggaagttcct ctaccacaag tccaaatgga atgtaaccat ggagtcctat     360

gtggtccaca ccaactatga tgagtatgcc atcattctaa ctaagaagtt cagccaccac     420

catggaccga ccattactgc caagctctat gggagagagc cgcggctgag agacagcctc     480

ctgcaggaat tcagggagat ggccctgggc gtaggcatcc ccgaggattc catcttcaca     540

atggccaaca gaggggaatg tgtccctggt gaccaggcac cagagtccac cccagccccg     600

aggtga                                                                606


<210> 61
<211> 594
<212> DNA
<213> Anura

<220> 
<223> 3. M8H5GIEGR-Frog

<400> 61
atgcatcacc atcaccatca ccatcacggt ggaggagggg gtatcgaggg ccgctgcagc      60

ccaatccagc cagaggacaa tatccagatc caggagaact ttgatctcca gaggatttat     120

ggcaaatggt acgacattgc catcggctcc acctgcaaat ggctgaagca ccacaaggaa     180

aagttcaaca tggggacact ggagcttagc gatggggaga ccgacgggga ggtgcggatt     240

gtgaacacaa ggatgaggca cggaacctgc tctcagattg ttgggtccta tcagaagaca     300

gagaccccag ggaagttcga ctatttcaac gcacggtggg gaaccacgat ccaaaactac     360

attgtcttca ctaactacaa tgagtatgtc atcatgcaga tgaggaagaa gaagggatcg     420

gagaccacca cgaccgtcaa gctgtatggg cggagcccag acttgcgtcc gaccctcgtt     480

gatgaattca ggcagtttgc cttggctcag ggcattcctg aagactccat cgtgatgcta     540

cctaacaatg gtgagtgctc tccaggggaa atagaagtga gaccacggag atga           594


<210> 62
<211> 594
<212> DNA
<213> Gallus gallus

<220> 
<223> 4. M8H5GIEGR-Chicken

<400> 62
atgcatcacc atcaccatca ccatcacggt ggaggagggg gtatcgaggg ccgcacgcct      60

gttggggacc aggatgagga cattcaagtg caagagaatt ttgagcctga gcggatgtat     120

gggaaatggt atgacgtagc tgttggcacc acctgcaagt ggatgaagaa ctacaaggag     180

aagttcagca tgggcacact ggtgctgggc cccggcccca gcgctgacca gatcagtacc     240

atcagcacca ggctgcggca aggtgactgc aaacgtgtct caggagagta ccagaaaact     300

gacacccctg gcaaatacac ctactataac cccaagtggg atgtgtctat caagtcctac     360

gtgcttcgca ccaactatga agaatacgca gtcattctga tgaagaagac aagtaatttt     420

ggcccaacca ccacactgaa gctgtatggg agaagcccag agctgcggga agagctcacc     480

gaggctttcc agcagctggc tctggagatg ggcatccctg cagattccgt cttcatcctg     540

gccaacaaag gtgaatgtgt cccacaggag actgccactg cccctgagag gtga           594


<210> 63
<211> 606
<212> DNA
<213> Oryctolagus

<220> 
<223> 5. M8H5GIEGR-Rabbit

<400> 63
atgcatcacc atcaccatca ccatcacggt ggaggagggg gtatcgaggg ccgcgacccc      60

gtgcccaccc tgccggacga catccaagtg caggagaact tcgagctctc tcggatctac     120

gggaaatggt acaacctggc tgtggggtcc acctgcccgt ggctgaagag gatcaaggac     180

aggatggccg tgagcacgct ggtgctggga gaggggacga gcgagacgga gatcagcatg     240

accagcacgc actggcggag gggcgtctgt gaggagatct ccggggccta tgagaaaacg     300

gacactgacg ggaagttcct gtaccacaaa gccaaatgga acttaaccat ggagtcctac     360

gtggtgcaca ccaactacga tgagtatgcc atttttctca ccaagaaatt cagccgccgc     420

cacggcccca ccatcaccgc caagctctat gggcgggagc cgcagctgag ggagagcctc     480

ctgcaggagt tcagggaggt ggctctcggg gtggggatcc ccgagaactc catcttcacc     540

atgatcgaca gaggggaatg tgtgcccggg cagcaggaac caaagcctgc ccccgtgttg     600

agatga                                                                606


<210> 64
<211> 606
<212> DNA
<213> Saimiri

<220> 
<223> 6. M8H5GIEGR-SQ Monkey

<400> 64
atgcatcacc atcaccatca ccatcacggt ggaggagggg gtatcgaggg ccgcagccca      60

gtgccgacgc cgcccgaagg cattcaagtg caggaaaact tcaatctctc tcggatctac     120

ggcaagtggt acaacctggc catcggttcc acctgcccct ggctaaagaa gatcatggac     180

aggttgaaag tgagcacgct ggtgctggaa gagggcgcca cggaggcgga gatcagcatg     240

accagcactc gctggcggaa aggtttctgt gagcagacct cttgggctta tgagaaaaca     300

gatactgatg ggaagtttct ctatcacgaa cccaaatgga acgtaaccat ggagtcctat     360

gtggcccaca ccaactatga ggagtatgcc attttcctga ccaagaaatt cagccgccat     420

catggaccca ccattactgc caagctctat gggcgggagc cacagctgag ggaaagcctc     480

ctgcaggact tcagagtggt tgcccagggt gtgggcatcc ctgaggattc catcttcacc     540

atggctaacc gaggtgaatg cgtccctggg gagcaggaac cacagcccat cctacaccgg     600

agatga                                                                606


<210> 65
<211> 606
<212> DNA
<213> Odobenus

<220> 
<223> 7. M8H5GIEGR-Walrus

<400> 65
atgcatcacc atcaccatca ccatcacggt ggaggagggg gtatcgaggg ccgcagtccc      60

gtgctgacgc cgcctgacgc catccaagtg caagagaact tcgacatctc tcggatctac     120

gggaagtggt ttcatgtggc catgggctcc acctgcccgt ggctgaagaa gttcatggac     180

aggatgtcca tgagcacgct ggtgctgggc gagggggcga cggatgggga gatcagcatg     240

accagcacac gttggcggag aggcacctgt gaggagatct ctggggctta tgagaaaacc     300

agcactaacg gaaagttcct ctatcataat cccaaatgga acatcaccat ggagtcctat     360

gtggtccaca ccgactatga tgagtacgcc atctttctga ccaagaaatt cagccgccac     420

catgggccca ccattactgc caagctctat gggcgacagc cgcagcttcg agaaagcctg     480

ctggaggagt tcagggagct tgccttgggt gtgggcatcc ccgaggactc catcttcacc     540

atggccaaca aaggtgagtg tgtccctggg gagcaggaac cagagccctc tccacacatg     600

aggtga                                                                606


<210> 66
<211> 603
<212> DNA
<213> Trichechus

<220> 
<223> 8. M8H5GIEGR-Manatee

<400> 66
atgcatcacc atcaccatca ccatcacggt ggaggagggg gtatcgaggg ccgcagccca      60

gtgaaaacac cactcaacga catccaagtg caggagaact ttgacctccc tcggatctac     120

gggaaatggt tcaacatagc cattggctcc acctgccaat ggctgaagag gttgaaggcc     180

gggccgacca tgagcaccct ggtcctggga gagggagcta cagacacaga gatcagcaca     240

accagcactc gttggcggaa aggcttctgt gaggagatct ctggggcata tgagaaaaca     300

gacacagctg ggaagttcct ttatcacgga tccaaatgga atgtaacctt ggagtcctat     360

gtggtccaca ccaactatga tgagtacgcc atttttctga ccaagaaatt cagccgctat     420

ggactcacca ttactgctaa gctctatggg cggcagcctc aggtgaggga gagcctcctg     480

gaggagttca gggaatttgc cctgggtgtg ggcatccctg aggattccat cttcaccacg     540

gccgacaaag gtgagtgtgt ccctggagag caggagccag aacccaccgc agccctgaga     600

tga                                                                   603


<210> 67
<211> 609
<212> DNA
<213> Pleuronectes platessa

<220> 
<223> 9. M8H5GIEGR-Plaice

<400> 67
atgcatcacc atcaccatca ccatcacggt ggaggagggg gtatcgaggg ccgcctccct      60

gtgctccctg aacctcttta cccgacacag gagaactttg atctgacccg gtttgtgggg     120

acatggcacg atgttgcctt gacgagcagc tgcccccata tgcagcgtaa cagggcggat     180

gcagccattg gtaaactggt tctggagaaa gacactggaa acaaactcaa ggtgacacga     240

actagactca gacatggaac atgtgtggag atgtctggag aatatgagtt aaccagcaca     300

ccaggacgaa tcttctacca tattgacagg tgggatgcag acgtggacgc ctacgtggtt     360

cacaccaact acgacgagta cgcaattata ataatgagca aacagaaaac atcgggggag     420

aacagcacct cactcaagct gtacagtcgg acgatgtctg tgagagacac tgtgctggat     480

gacttcaaaa ctctggtcag acatcaggga atgagtgacg acaccattat catcaagcag     540

aacaaaggtg actgtattcc tggagagcag gtggaagaag caccatctca gccagagccc     600

aagcggtga                                                             609


<210> 68
<211> 606
<212> DNA
<213> Pongo

<220> 
<223> 10. M8H5GIEGR-Orangutan

<400> 68
atgcatcacc atcaccatca ccatcacggt ggaggagggg gtatcgaggg ccgcggccct      60

gtgccgacgc cgcccgacaa catccaagtg caggaaaact tcaatatctc tcggatctat     120

gggaagtggt acaacctggc catcggttcc acctgcccct ggctgaagaa gatcatggac     180

aggatgacag tgagcaccct ggtgctggga gagggcgcta cagaggcgga gatcagcatg     240

accagcactc gttggcggaa aggtgtctgt gaggagacat ctggagctta tgagaaaaca     300

gatactgatg ggaagtttct ctatcacaaa tccaaatgga acataaccat ggagtcctat     360

gtggtccaca ccaactatga tgagtatgcc attttcctga ccaagaaatt cagccgccgt     420

catggaccca ccattactgc caagctctac gggcgggcgc cgcagctgag ggaaaccctc     480

ctgcaggact tcagagtggt tgcccagggt gtgggcatcc ctgaggactc catcttcacc     540

atggctgacc gaggtgaatg tgtccctggg gaacaggaac cagagcccat cttaatcccg     600

agatga                                                                606


<210> 69
<211> 606
<212> DNA
<213> Homo sapiens

<220> 
<223> 11. M8H5GIEGR-Human P35K

<400> 69
atgcatcacc atcaccatca ccatcacggt ggaggagggg gtatcgaggg ccgcggccct      60

gtgccaacgc cgcccgacaa catccaagtg caggaaaact tcaatatctc tcggatctat     120

gggaagtggt acaacctggc catcggttcc acctgcaaat ggctgaagaa gatcatggac     180

aggatgacag tgagcacgct ggtgctggga gagggcgcta cagaggcgga gatcagcatg     240

accagcactc gttggcggaa aggtgtctgt gaggagacgt ctggagctta tgagaaaaca     300

gatactgatg ggaagtttct ctatcacaaa tccaaatgga acataaccat ggagtcctat     360

gtggtccaca ccaactatga tgagtatgcc attttcctga ccaagaaatt cagccgccat     420

catggaccca ccattactgc caagctctac gggcgggcgc cgcagctgag ggaaactctc     480

ctgcaggact tcagagtggt tgcccagggt gtgggcatcc ctgaggactc catcttcacc     540

atggctgacc gaggtgaatg tgtccctggg gagcaggaac cagagcccat cttaatcccg     600

agatga                                                                606


<210> 70
<211> 606
<212> DNA
<213> Homo sapiens

<220> 
<223> 12. M8H5GIEGR-Human M41K

<400> 70
atgcatcacc atcaccatca ccatcacggt ggaggagggg gtatcgaggg ccgcggccct      60

gtgccaacgc cgcccgacaa catccaagtg caggaaaact tcaatatctc tcggatctat     120

gggaagtggt acaacctggc catcggttcc acctgcccct ggctgaagaa gatcaaagac     180

aggatgacag tgagcacgct ggtgctggga gagggcgcta cagaggcgga gatcagcatg     240

accagcactc gttggcggaa aggtgtctgt gaggagacgt ctggagctta tgagaaaaca     300

gatactgatg ggaagtttct ctatcacaaa tccaaatgga acataaccat ggagtcctat     360

gtggtccaca ccaactatga tgagtatgcc attttcctga ccaagaaatt cagccgccat     420

catggaccca ccattactgc caagctctac gggcgggcgc cgcagctgag ggaaactctc     480

ctgcaggact tcagagtggt tgcccagggt gtgggcatcc ctgaggactc catcttcacc     540

atggctgacc gaggtgaatg tgtccctggg gagcaggaac cagagcccat cttaatcccg     600

agatga                                                                606


<210> 71
<211> 606
<212> DNA
<213> Homo sapiens

<220> 
<223> 13. M8H5GIEGR-Human R66H

<400> 71
atgcatcacc atcaccatca ccatcacggt ggaggagggg gtatcgaggg ccgcggccct      60

gtgccaacgc cgcccgacaa catccaagtg caggaaaact tcaatatctc tcggatctat     120

gggaagtggt acaacctggc catcggttcc acctgcccct ggctgaagaa gatcatggac     180

aggatgacag tgagcacgct ggtgctggga gagggcgcta cagaggcgga gatcagcatg     240

accagcactc attggcggaa aggtgtctgt gaggagacgt ctggagctta tgagaaaaca     300

gatactgatg ggaagtttct ctatcacaaa tccaaatgga acataaccat ggagtcctat     360

gtggtccaca ccaactatga tgagtatgcc attttcctga ccaagaaatt cagccgccat     420

catggaccca ccattactgc caagctctac gggcgggcgc cgcagctgag ggaaactctc     480

ctgcaggact tcagagtggt tgcccagggt gtgggcatcc ctgaggactc catcttcacc     540

atggctgacc gaggtgaatg tgtccctggg gagcaggaac cagagcccat cttaatcccg     600

agatga                                                                606


<210> 72
<211> 606
<212> DNA
<213> Homo sapiens

<220> 
<223> 14. M8H5GIEGR-Human T75K

<400> 72
atgcatcacc atcaccatca ccatcacggt ggaggagggg gtatcgaggg ccgcggccct      60

gtgccaacgc cgcccgacaa catccaagtg caggaaaact tcaatatctc tcggatctat     120

gggaagtggt acaacctggc catcggttcc acctgcccct ggctgaagaa gatcatggac     180

aggatgacag tgagcacgct ggtgctggga gagggcgcta cagaggcgga gatcagcatg     240

accagcactc gttggcggaa aggtgtctgt gaggagaaat ctggagctta tgagaaaaca     300

gatactgatg ggaagtttct ctatcacaaa tccaaatgga acataaccat ggagtcctat     360

gtggtccaca ccaactatga tgagtatgcc attttcctga ccaagaaatt cagccgccat     420

catggaccca ccattactgc caagctctac gggcgggcgc cgcagctgag ggaaactctc     480

ctgcaggact tcagagtggt tgcccagggt gtgggcatcc ctgaggactc catcttcacc     540

atggctgacc gaggtgaatg tgtccctggg gagcaggaac cagagcccat cttaatcccg     600

agatga                                                                606


<210> 73
<211> 606
<212> DNA
<213> Homo sapiens

<220> 
<223> 15. M8H5GIEGR-Human T75Y

<400> 73
atgcatcacc atcaccatca ccatcacggt ggaggagggg gtatcgaggg ccgcggccct      60

gtgccaacgc cgcccgacaa catccaagtg caggaaaact tcaatatctc tcggatctat     120

gggaagtggt acaacctggc catcggttcc acctgcccct ggctgaagaa gatcatggac     180

aggatgacag tgagcacgct ggtgctggga gagggcgcta cagaggcgga gatcagcatg     240

accagcactc gttggcggaa aggtgtctgt gaggagtatt ctggagctta tgagaaaaca     300

gatactgatg ggaagtttct ctatcacaaa tccaaatgga acataaccat ggagtcctat     360

gtggtccaca ccaactatga tgagtatgcc attttcctga ccaagaaatt cagccgccat     420

catggaccca ccattactgc caagctctac gggcgggcgc cgcagctgag ggaaactctc     480

ctgcaggact tcagagtggt tgcccagggt gtgggcatcc ctgaggactc catcttcacc     540

atggctgacc gaggtgaatg tgtccctggg gagcaggaac cagagcccat cttaatcccg     600

agatga                                                                606


<210> 74
<211> 606
<212> DNA
<213> Homo sapiens

<220> 
<223> 16. M8H5GIEGR-Human M99K

<400> 74
atgcatcacc atcaccatca ccatcacggt ggaggagggg gtatcgaggg ccgcggccct      60

gtgccaacgc cgcccgacaa catccaagtg caggaaaact tcaatatctc tcggatctat     120

gggaagtggt acaacctggc catcggttcc acctgcccct ggctgaagaa gatcatggac     180

aggatgacag tgagcacgct ggtgctggga gagggcgcta cagaggcgga gatcagcatg     240

accagcactc gttggcggaa aggtgtctgt gaggagacgt ctggagctta tgagaaaaca     300

gatactgatg ggaagtttct ctatcacaaa tccaaatgga acataaccaa agagtcctat     360

gtggtccaca ccaactatga tgagtatgcc attttcctga ccaagaaatt cagccgccat     420

catggaccca ccattactgc caagctctac gggcgggcgc cgcagctgag ggaaactctc     480

ctgcaggact tcagagtggt tgcccagggt gtgggcatcc ctgaggactc catcttcacc     540

atggctgacc gaggtgaatg tgtccctggg gagcaggaac cagagcccat cttaatcccg     600

agatga                                                                606


<210> 75
<211> 606
<212> DNA
<213> Homo sapiens

<220> 
<223> 17. M8H5GIEGR-Human S101Y

<400> 75
atgcatcacc atcaccatca ccatcacggt ggaggagggg gtatcgaggg ccgcggccct      60

gtgccaacgc cgcccgacaa catccaagtg caggaaaact tcaatatctc tcggatctat     120

gggaagtggt acaacctggc catcggttcc acctgcccct ggctgaagaa gatcatggac     180

aggatgacag tgagcacgct ggtgctggga gagggcgcta cagaggcgga gatcagcatg     240

accagcactc gttggcggaa aggtgtctgt gaggagacgt ctggagctta tgagaaaaca     300

gatactgatg ggaagtttct ctatcacaaa tccaaatgga acataaccat ggagtattat     360

gtggtccaca ccaactatga tgagtatgcc attttcctga ccaagaaatt cagccgccat     420

catggaccca ccattactgc caagctctac gggcgggcgc cgcagctgag ggaaactctc     480

ctgcaggact tcagagtggt tgcccagggt gtgggcatcc ctgaggactc catcttcacc     540

atggctgacc gaggtgaatg tgtccctggg gagcaggaac cagagcccat cttaatcccg     600

agatga                                                                606


<210> 76
<211> 606
<212> DNA
<213> Homo sapiens

<220> 
<223> 18. M8H5GIEGR-Human K69.92.118.

<400> 76
atgcatcacc atcaccatca ccatcacggt ggaggagggg gtatcgaggg ccgcggccct      60

gtgccaacgc cgcccgacaa catccaagtg caggaaaact tcaatatctc tcggatctat     120

gggaagtggt acaacctggc catcggttcc acctgcccct ggctgaagaa gatcatggac     180

aggatgacag tgagcacgct ggtgctggga gagggcgcta cagaggcgga gatcagcatg     240

accagcactc gttggcggcg tggtgtctgt gaggagacgt ctggagctta tgagaaaaca     300

gatactgatg ggaagtttct ctatcaccgt tccaaatgga acataaccat ggagtcctat     360

gtggtccaca ccaactatga tgagtatgcc attttcctga ccaagcgttt cagccgccat     420

catggaccca ccattactgc ccgtctctac gggcgggcgc cgcagctgag ggaaactctc     480

ctgcaggact tcagagtggt tgcccagggt gtgggcatcc ctgaggactc catcttcacc     540

atggctgacc gaggtgaatg tgtccctggg gagcaggaac cagagcccat cttaatcccg     600

agatga                                                                606


<210> 77
<211> 597
<212> DNA
<213> Latimeria

<220> 
<223> 19. M8H5GIEGR-Coelacanth

<400> 77
atgcatcacc atcaccatca ccatcacggt ggaggagggg gtatcgaggg ccgcggaagt      60

ccccttcgag atgaagacat ccaagtgcag gagaactttg accttcccag gatttatgga     120

aaatggtacg aaattgcaat cgcttcgacc tgtccctggg tgaagaatca caaggataag     180

atgttcatgg gaactatggt gctacaagag ggagagcaga gtgaccggat cagtaccacc     240

tccacccgaa tcagggatgg aacctgctca cagatcactg gatattacac gttaaccaca     300

acacctggga agttcgctta tcacaattct aaatggaact tggatgtcaa cagttatgtt     360

gttcacacta actatgacga atactcgatt gtgatgatgc agaaatacaa aagctctaac     420

tctaccacta cagtccgact ctatggaaga actcaagagc tacgagacag cttgcatgcc     480

gagttcaaaa agtttgctct ggatcaggga atagatgagg actccattta cattctgcca     540

aaaagagatg aatgtgtacc tggtgaacct aaagcagaat ctctcatggc acgttga        597


<210> 78
<211> 606
<212> DNA
<213> Homo sapiens

<220> 
<223> 21. M8H5GIEGR-Human L89T

<400> 78
atgcatcacc atcaccatca ccatcacggt ggaggagggg gtatcgaggg ccgcggccct      60

gtgccaacgc cgcccgacaa catccaagtg caggaaaact tcaatatctc tcggatctat     120

gggaagtggt acaacctggc catcggttcc acctgcccct ggctgaagaa gatcatggac     180

aggatgacag tgagcacgct ggtgctggga gagggcgcta cagaggcgga gatcagcatg     240

accagcactc gttggcggaa aggtgtctgt gaggagacgt ctggagctta tgagaaaaca     300

gatactgatg ggaagtttac ctatcacaaa tccaaatgga acataaccat ggagtcctat     360

gtggtccaca ccaactatga tgagtatgcc attttcctga ccaagaaatt cagccgccat     420

catggaccca ccattactgc caagctctac gggcgggcgc cgcagctgag ggaaactctc     480

ctgcaggact tcagagtggt tgcccagggt gtgggcatcc ctgaggactc catcttcacc     540

atggctgacc gaggtgaatg tgtccctggg gagcaggaac cagagcccat cttaatcccg     600

agatga                                                                606


<210> 79
<211> 606
<212> DNA
<213> Homo sapiens

<220> 
<223> 22. M8H5GIEGR-Human N1796D

<400> 79
atgcatcacc atcaccatca ccatcacggt ggaggagggg gtatcgaggg ccgcggccct      60

gtgccaacgc cgcccgacaa catccaagtg caggaaaact tcgatatctc tcggatctat     120

gggaagtggt acaacctggc catcggttcc acctgcccct ggctgaagaa gatcatggac     180

aggatgacag tgagcacgct ggtgctggga gagggcgcta cagaggcgga gatcagcatg     240

accagcactc gttggcggaa aggtgtctgt gaggagacgt ctggagctta tgagaaaaca     300

gatactgatg ggaagtttct ctatcacaaa tccaaatggg atataaccat ggagtcctat     360

gtggtccaca ccaactatga tgagtatgcc attttcctga ccaagaaatt cagccgccat     420

catggaccca ccattactgc caagctctac gggcgggcgc cgcagctgag ggaaactctc     480

ctgcaggact tcagagtggt tgcccagggt gtgggcatcc ctgaggactc catcttcacc     540

atggctgacc gaggtgaatg tgtccctggg gagcaggaac cagagcccat cttaatcccg     600

agatga                                                                606


<210> 80
<211> 606
<212> DNA
<213> Homo sapiens

<220> 
<223> 23. M8H5GIEGR-Human T45K

<400> 80
atgcatcacc atcaccatca ccatcacggt ggaggagggg gtatcgaggg ccgcggccct      60

gtgccaacgc cgcccgacaa catccaagtg caggaaaact tcaatatctc tcggatctat     120

gggaagtggt acaacctggc catcggttcc acctgcccct ggctgaagaa gatcatggac     180

aggatgaaag tgagcacgct ggtgctggga gagggcgcta cagaggcgga gatcagcatg     240

accagcactc gttggcggaa aggtgtctgt gaggagacgt ctggagctta tgagaaaaca     300

gatactgatg ggaagtttct ctatcacaaa tccaaatgga acataaccat ggagtcctat     360

gtggtccaca ccaactatga tgagtatgcc attttcctga ccaagaaatt cagccgccat     420

catggaccca ccattactgc caagctctac gggcgggcgc cgcagctgag ggaaactctc     480

ctgcaggact tcagagtggt tgcccagggt gtgggcatcc ctgaggactc catcttcacc     540

atggctgacc gaggtgaatg tgtccctggg gagcaggaac cagagcccat cttaatcccg     600

agatga                                                                606


<210> 81
<211> 606
<212> DNA
<213> Homo sapiens

<220> 
<223> 24. M8H5GIEGR-Human A135E

<400> 81
atgcatcacc atcaccatca ccatcacggt ggaggagggg gtatcgaggg ccgcggccct      60

gtgccaacgc cgcccgacaa catccaagtg caggaaaact tcaatatctc tcggatctat     120

gggaagtggt acaacctggc catcggttcc acctgcccct ggctgaagaa gatcatggac     180

aggatgacag tgagcacgct ggtgctggga gagggcgcta cagaggcgga gatcagcatg     240

accagcactc gttggcggaa aggtgtctgt gaggagacgt ctggagctta tgagaaaaca     300

gatactgatg ggaagtttct ctatcacaaa tccaaatgga acataaccat ggagtcctat     360

gtggtccaca ccaactatga tgagtatgcc attttcctga ccaagaaatt cagccgccat     420

catggaccca ccattactgc caagctctac gggcgggaac cgcagctgag ggaaactctc     480

ctgcaggact tcagagtggt tgcccagggt gtgggcatcc ctgaggactc catcttcacc     540

atggctgacc gaggtgaatg tgtccctggg gagcaggaac cagagcccat cttaatcccg     600

agatga                                                                606


<210> 82
<211> 606
<212> DNA
<213> Homo sapiens

<220> 
<223> 25. M8H5GIEGR-Human V170S

<400> 82
atgcatcacc atcaccatca ccatcacggt ggaggagggg gtatcgaggg ccgcggccct      60

gtgccaacgc cgcccgacaa catccaagtg caggaaaact tcaatatctc tcggatctat     120

gggaagtggt acaacctggc catcggttcc acctgcccct ggctgaagaa gatcatggac     180

aggatgacag tgagcacgct ggtgctggga gagggcgcta cagaggcgga gatcagcatg     240

accagcactc gttggcggaa aggtgtctgt gaggagacgt ctggagctta tgagaaaaca     300

gatactgatg ggaagtttct ctatcacaaa tccaaatgga acataaccat ggagtcctat     360

gtggtccaca ccaactatga tgagtatgcc attttcctga ccaagaaatt cagccgccat     420

catggaccca ccattactgc caagctctac gggcgggcgc cgcagctgag ggaaactctc     480

ctgcaggact tcagagtggt tgcccagggt gtgggcatcc ctgaggactc catcttcacc     540

atggctgacc gaggtgaatg ttctcctggg gagcaggaac cagagcccat cttaatcccg     600

agatga                                                                606


<210> 83
<211> 606
<212> DNA
<213> Homo sapiens

<220> 
<223> 26. M8H5GIEGR-Human V148D

<400> 83
atgcatcacc atcaccatca ccatcacggt ggaggagggg gtatcgaggg ccgcggccct      60

gtgccaacgc cgcccgacaa catccaagtg caggaaaact tcaatatctc tcggatctat     120

gggaagtggt acaacctggc catcggttcc acctgcccct ggctgaagaa gatcatggac     180

aggatgacag tgagcacgct ggtgctggga gagggcgcta cagaggcgga gatcagcatg     240

accagcactc gttggcggaa aggtgtctgt gaggagacgt ctggagctta tgagaaaaca     300

gatactgatg ggaagtttct ctatcacaaa tccaaatgga acataaccat ggagtcctat     360

gtggtccaca ccaactatga tgagtatgcc attttcctga ccaagaaatt cagccgccat     420

catggaccca ccattactgc caagctctac gggcgggcgc cgcagctgag ggaaactctc     480

ctgcaggact tcagagatgt tgcccagggt gtgggcatcc ctgaggactc catcttcacc     540

atggctgacc gaggtgaatg tgtccctggg gagcaggaac cagagcccat cttaatcccg     600

agatga                                                                606


<210> 84
<211> 606
<212> DNA
<213> Homo sapiens

<220> 
<223> 27. M8H5GIEGR-Human G172Q

<400> 84
atgcatcacc atcaccatca ccatcacggt ggaggagggg gtatcgaggg ccgcggccct      60

gtgccaacgc cgcccgacaa catccaagtg caggaaaact tcaatatctc tcggatctat     120

gggaagtggt acaacctggc catcggttcc acctgcccct ggctgaagaa gatcatggac     180

aggatgacag tgagcacgct ggtgctggga gagggcgcta cagaggcgga gatcagcatg     240

accagcactc gttggcggaa aggtgtctgt gaggagacgt ctggagctta tgagaaaaca     300

gatactgatg ggaagtttct ctatcacaaa tccaaatgga acataaccat ggagtcctat     360

gtggtccaca ccaactatga tgagtatgcc attttcctga ccaagaaatt cagccgccat     420

catggaccca ccattactgc caagctctac gggcgggcgc cgcagctgag ggaaactctc     480

ctgcaggact tcagagtggt tgcccagggt gtgggcatcc ctgaggactc catcttcacc     540

atggctgacc gaggtgaatg tgtccctcag gagcaggaac cagagcccat cttaatcccg     600

agatga                                                                606


<210> 85
<211> 594
<212> DNA
<213> Homo sapiens

<220> 
<223> 33. M8H4DK-Human M41K+R66H

<400> 85
atgcatcacc atcaccatca ccatcacgat gacgatgaca agggccctgt gccaacgccg      60

cccgacaaca tccaagtgca ggaaaacttc aatatctctc ggatctatgg gaagtggtac     120

aacctggcca tcggttccac ctgcccctgg ctgaagaaga tcaaagacag gatgacagtg     180

agcacgctgg tgctgggaga gggcgctaca gaggcggaga tcagcatgac cagcactcat     240

tggcggaaag gtgtctgtga ggagacgtct ggagcttatg agaaaacaga tactgatggg     300

aagtttctct atcacaaatc caaatggaac ataaccatgg agtcctatgt ggtccacacc     360

aactatgatg agtatgccat tttcctgacc aagaaattca gccgccatca tggacccacc     420

attactgcca agctctacgg gcgggcgccg cagctgaggg aaactctcct gcaggacttc     480

agagtggttg cccagggtgt gggcatccct gaggactcca tcttcaccat ggctgaccga     540

ggtgaatgtg tccctgggga gcaggaacca gagcccatct taatcccgag atga           594


<210> 86
<211> 594
<212> DNA
<213> Homo sapiens

<220> 
<223> 34. M8H4DK-Human M41K+N1796D

<400> 86
atgcatcacc atcaccatca ccatcacgat gacgatgaca agggccctgt gccaacgccg      60

cccgacaaca tccaagtgca ggaaaacttc gatatctctc ggatctatgg gaagtggtac     120

aacctggcca tcggttccac ctgcccctgg ctgaagaaga tcaaagacag gatgacagtg     180

agcacgctgg tgctgggaga gggcgctaca gaggcggaga tcagcatgac cagcactcgt     240

tggcggaaag gtgtctgtga ggagacgtct ggagcttatg agaaaacaga tactgatggg     300

aagtttctct atcacaaatc caaatgggat ataaccatgg agtcctatgt ggtccacacc     360

aactatgatg agtatgccat tttcctgacc aagaaattca gccgccatca tggacccacc     420

attactgcca agctctacgg gcgggcgccg cagctgaggg aaactctcct gcaggacttc     480

agagtggttg cccagggtgt gggcatccct gaggactcca tcttcaccat ggctgaccga     540

ggtgaatgtg tccctgggga gcaggaacca gagcccatct taatcccgag atga           594


<210> 87
<211> 594
<212> DNA
<213> Homo sapiens

<220> 
<223> 35. M8H4DK-Human R66H+N1796D

<400> 87
atgcatcacc atcaccatca ccatcacgat gacgatgaca agggccctgt gccaacgccg      60

cccgacaaca tccaagtgca ggaaaacttc gatatctctc ggatctatgg gaagtggtac     120

aacctggcca tcggttccac ctgcccctgg ctgaagaaga tcatggacag gatgacagtg     180

agcacgctgg tgctgggaga gggcgctaca gaggcggaga tcagcatgac cagcactcat     240

tggcggaaag gtgtctgtga ggagacgtct ggagcttatg agaaaacaga tactgatggg     300

aagtttctct atcacaaatc caaatgggat ataaccatgg agtcctatgt ggtccacacc     360

aactatgatg agtatgccat tttcctgacc aagaaattca gccgccatca tggacccacc     420

attactgcca agctctacgg gcgggcgccg cagctgaggg aaactctcct gcaggacttc     480

agagtggttg cccagggtgt gggcatccct gaggactcca tcttcaccat ggctgaccga     540

ggtgaatgtg tccctgggga gcaggaacca gagcccatct taatcccgag atga           594


<210> 88
<211> 594
<212> DNA
<213> Homo sapiens

<220> 
<223> 36. M8H4DK-Human M41K+R66H+N1796D

<400> 88
atgcatcacc atcaccatca ccatcacgat gacgatgaca agggccctgt gccaacgccg      60

cccgacaaca tccaagtgca ggaaaacttc gatatctctc ggatctatgg gaagtggtac     120

aacctggcca tcggttccac ctgcccctgg ctgaagaaga tcaaagacag gatgacagtg     180

agcacgctgg tgctgggaga gggcgctaca gaggcggaga tcagcatgac cagcactcat     240

tggcggaaag gtgtctgtga ggagacgtct ggagcttatg agaaaacaga tactgatggg     300

aagtttctct atcacaaatc caaatgggat ataaccatgg agtcctatgt ggtccacacc     360

aactatgatg agtatgccat tttcctgacc aagaaattca gccgccatca tggacccacc     420

attactgcca agctctacgg gcgggcgccg cagctgaggg aaactctcct gcaggacttc     480

agagtggttg cccagggtgt gggcatccct gaggactcca tcttcaccat ggctgaccga     540

ggtgaatgtg tccctgggga gcaggaacca gagcccatct taatcccgag atga           594


<210> 89
<211> 594
<212> DNA
<213> Homo sapiens

<220> 
<223> 37. M8H4DK-Human M41K

<400> 89
atgcatcacc atcaccatca ccatcacgat gacgatgaca agggccctgt gccaacgccg      60

cccgacaaca tccaagtgca ggaaaacttc aatatctctc ggatctatgg gaagtggtac     120

aacctggcca tcggttccac ctgcccctgg ctgaagaaga tcaaagacag gatgacagtg     180

agcacgctgg tgctgggaga gggcgctaca gaggcggaga tcagcatgac cagcactcgt     240

tggcggaaag gtgtctgtga ggagacgtct ggagcttatg agaaaacaga tactgatggg     300

aagtttctct atcacaaatc caaatggaac ataaccatgg agtcctatgt ggtccacacc     360

aactatgatg agtatgccat tttcctgacc aagaaattca gccgccatca tggacccacc     420

attactgcca agctctacgg gcgggcgccg cagctgaggg aaactctcct gcaggacttc     480

agagtggttg cccagggtgt gggcatccct gaggactcca tcttcaccat ggctgaccga     540

ggtgaatgtg tccctgggga gcaggaacca gagcccatct taatcccgag atga           594


<210> 90
<211> 594
<212> DNA
<213> Homo sapiens

<220> 
<223> 38. M8H4DK-Human R66H

<400> 90
atgcatcacc atcaccatca ccatcacgat gacgatgaca agggccctgt gccaacgccg      60

cccgacaaca tccaagtgca ggaaaacttc aatatctctc ggatctatgg gaagtggtac     120

aacctggcca tcggttccac ctgcccctgg ctgaagaaga tcatggacag gatgacagtg     180

agcacgctgg tgctgggaga gggcgctaca gaggcggaga tcagcatgac cagcactcat     240

tggcggaaag gtgtctgtga ggagacgtct ggagcttatg agaaaacaga tactgatggg     300

aagtttctct atcacaaatc caaatggaac ataaccatgg agtcctatgt ggtccacacc     360

aactatgatg agtatgccat tttcctgacc aagaaattca gccgccatca tggacccacc     420

attactgcca agctctacgg gcgggcgccg cagctgaggg aaactctcct gcaggacttc     480

agagtggttg cccagggtgt gggcatccct gaggactcca tcttcaccat ggctgaccga     540

ggtgaatgtg tccctgggga gcaggaacca gagcccatct taatcccgag atga           594


<210> 91
<211> 594
<212> DNA
<213> Homo sapiens

<220> 
<223> 39. M8H4DK-Human N1796D

<400> 91
atgcatcacc atcaccatca ccatcacgat gacgatgaca agggccctgt gccaacgccg      60

cccgacaaca tccaagtgca ggaaaacttc gatatctctc ggatctatgg gaagtggtac     120

aacctggcca tcggttccac ctgcccctgg ctgaagaaga tcatggacag gatgacagtg     180

agcacgctgg tgctgggaga gggcgctaca gaggcggaga tcagcatgac cagcactcgt     240

tggcggaaag gtgtctgtga ggagacgtct ggagcttatg agaaaacaga tactgatggg     300

aagtttctct atcacaaatc caaatgggat ataaccatgg agtcctatgt ggtccacacc     360

aactatgatg agtatgccat tttcctgacc aagaaattca gccgccatca tggacccacc     420

attactgcca agctctacgg gcgggcgccg cagctgaggg aaactctcct gcaggacttc     480

agagtggttg cccagggtgt gggcatccct gaggactcca tcttcaccat ggctgaccga     540

ggtgaatgtg tccctgggga gcaggaacca gagcccatct taatcccgag atga           594


<210> 92
<211> 579
<212> DNA
<213> Homo sapiens

<220> 
<223> 40. M8H-Human wt

<400> 92
atgcatcacc atcaccatca ccatcacggc cctgtgccaa cgccgcccga caacatccaa      60

gtgcaggaaa acttcaatat ctctcggatc tatgggaagt ggtacaacct ggccatcggt     120

tccacctgcc cctggctgaa gaagatcatg gacaggatga cagtgagcac gctggtgctg     180

ggagagggcg ctacagaggc ggagatcagc atgaccagca ctcgttggcg gaaaggtgtc     240

tgtgaggaga cgtctggagc ttatgagaaa acagatactg atgggaagtt tctctatcac     300

aaatccaaat ggaacataac catggagtcc tatgtggtcc acaccaacta tgatgagtat     360

gccattttcc tgaccaagaa attcagccgc catcatggac ccaccattac tgccaagctc     420

tacgggcggg cgccgcagct gagggaaact ctcctgcagg acttcagagt ggttgcccag     480

ggtgtgggca tccctgagga ctccatcttc accatggctg accgaggtga atgtgtccct     540

ggggagcagg aaccagagcc catcttaatc ccgagatga                            579


<210> 93
<211> 579
<212> DNA
<213> Homo sapiens

<220> 
<223> 41. M8H-Human R66H+N1796D

<400> 93
atgcatcacc atcaccatca ccatcacggc cctgtgccaa cgccgcccga caacatccaa      60

gtgcaggaaa acttcgatat ctctcggatc tatgggaagt ggtacaacct ggccatcggt     120

tccacctgcc cctggctgaa gaagatcatg gacaggatga cagtgagcac gctggtgctg     180

ggagagggcg ctacagaggc ggagatcagc atgaccagca ctcattggcg gaaaggtgtc     240

tgtgaggaga cgtctggagc ttatgagaaa acagatactg atgggaagtt tctctatcac     300

aaatccaaat gggatataac catggagtcc tatgtggtcc acaccaacta tgatgagtat     360

gccattttcc tgaccaagaa attcagccgc catcatggac ccaccattac tgccaagctc     420

tacgggcggg cgccgcagct gagggaaact ctcctgcagg acttcagagt ggttgcccag     480

ggtgtgggca tccctgagga ctccatcttc accatggctg accgaggtga atgtgtccct     540

ggggagcagg aaccagagcc catcttaatc ccgagatga                            579


<210> 94
<211> 555
<212> DNA
<213> Homo sapiens

<220> 
<223> 42. untagged-Human R66H+N1796D

<400> 94
atgggccctg tgccaacgcc gcccgacaac atccaagtgc aggaaaactt cgatatctct      60

cggatctatg ggaagtggta caacctggcc atcggttcca cctgcccctg gctgaagaag     120

atcatggaca ggatgacagt gagcacgctg gtgctgggag agggcgctac agaggcggag     180

atcagcatga ccagcactca ttggcggaaa ggtgtctgtg aggagacgtc tggagcttat     240

gagaaaacag atactgatgg gaagtttctc tatcacaaat ccaaatggga tataaccatg     300

gagtcctatg tggtccacac caactatgat gagtatgcca ttttcctgac caagaaattc     360

agccgccatc atggacccac cattactgcc aagctctacg ggcgggcgcc gcagctgagg     420

gaaactctcc tgcaggactt cagagtggtt gcccagggtg tgggcatccc tgaggactcc     480

atcttcacca tggctgaccg aggtgaatgt gtccctgggg agcaggaacc agagcccatc     540

ttaatcccga gatga                                                      555


<210> 95
<211> 555
<212> DNA
<213> Homo sapiens

<220> 
<223> 61. untagged-Human wt

<400> 95
atgggccctg tgccaacgcc gcccgacaac atccaagtgc aggaaaactt caatatctct      60

cggatctatg ggaagtggta caacctggcc atcggttcca cctgcccctg gctgaagaag     120

atcatggaca ggatgacagt gagcacgctg gtgctgggag agggcgctac agaggcggag     180

atcagcatga ccagcactcg ttggcggaaa ggtgtctgtg aggagacgtc tggagcttat     240

gagaaaacag atactgatgg gaagtttctc tatcacaaat ccaaatggaa cataaccatg     300

gagtcctatg tggtccacac caactatgat gagtatgcca ttttcctgac caagaaattc     360

agccgccatc atggacccac cattactgcc aagctctacg ggcgggcgcc gcagctgagg     420

gaaactctcc tgcaggactt cagagtggtt gcccagggtg tgggcatccc tgaggactcc     480

atcttcacca tggctgaccg aggtgaatgt gtccctgggg agcaggaacc agagcccatc     540

ttaatcccga gatga                                                      555




