               SEQUENCE LISTING

<110> Oryzon Genomics, S.A.

<120> Methods to determine KDMA1 target engagement and chemoprobes useful therefor

<130> Z1291 PCT S3

<150> EP16 38 2119.2
<151> 2016-03-16

<160> 2

<170> BiSSAP 1.3

<210> 1
<211> 852
<212> PRT
<213> Homo sapiens

<220> 
<223> KDM1A protein

<400> 1
Met Leu Ser Gly Lys Lys Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala 
1               5                   10                  15      
Ala Ala Thr Gly Thr Glu Ala Gly Pro Gly Thr Ala Gly Gly Ser Glu 
            20                  25                  30          
Asn Gly Ser Glu Val Ala Ala Gln Pro Ala Gly Leu Ser Gly Pro Ala 
        35                  40                  45              
Glu Val Gly Pro Gly Ala Val Gly Glu Arg Thr Pro Arg Lys Lys Glu 
    50                  55                  60                  
Pro Pro Arg Ala Ser Pro Pro Gly Gly Leu Ala Glu Pro Pro Gly Ser 
65                  70                  75                  80  
Ala Gly Pro Gln Ala Gly Pro Thr Val Val Pro Gly Ser Ala Thr Pro 
                85                  90                  95      
Met Glu Thr Gly Ile Ala Glu Thr Pro Glu Gly Arg Arg Thr Ser Arg 
            100                 105                 110         
Arg Lys Arg Ala Lys Val Glu Tyr Arg Glu Met Asp Glu Ser Leu Ala 
        115                 120                 125             
Asn Leu Ser Glu Asp Glu Tyr Tyr Ser Glu Glu Glu Arg Asn Ala Lys 
    130                 135                 140                 
Ala Glu Lys Glu Lys Lys Leu Pro Pro Pro Pro Pro Gln Ala Pro Pro 
145                 150                 155                 160 
Glu Glu Glu Asn Glu Ser Glu Pro Glu Glu Pro Ser Gly Val Glu Gly 
                165                 170                 175     
Ala Ala Phe Gln Ser Arg Leu Pro His Asp Arg Met Thr Ser Gln Glu 
            180                 185                 190         
Ala Ala Cys Phe Pro Asp Ile Ile Ser Gly Pro Gln Gln Thr Gln Lys 
        195                 200                 205             
Val Phe Leu Phe Ile Arg Asn Arg Thr Leu Gln Leu Trp Leu Asp Asn 
    210                 215                 220                 
Pro Lys Ile Gln Leu Thr Phe Glu Ala Thr Leu Gln Gln Leu Glu Ala 
225                 230                 235                 240 
Pro Tyr Asn Ser Asp Thr Val Leu Val His Arg Val His Ser Tyr Leu 
                245                 250                 255     
Glu Arg His Gly Leu Ile Asn Phe Gly Ile Tyr Lys Arg Ile Lys Pro 
            260                 265                 270         
Leu Pro Thr Lys Lys Thr Gly Lys Val Ile Ile Ile Gly Ser Gly Val 
        275                 280                 285             
Ser Gly Leu Ala Ala Ala Arg Gln Leu Gln Ser Phe Gly Met Asp Val 
    290                 295                 300                 
Thr Leu Leu Glu Ala Arg Asp Arg Val Gly Gly Arg Val Ala Thr Phe 
305                 310                 315                 320 
Arg Lys Gly Asn Tyr Val Ala Asp Leu Gly Ala Met Val Val Thr Gly 
                325                 330                 335     
Leu Gly Gly Asn Pro Met Ala Val Val Ser Lys Gln Val Asn Met Glu 
            340                 345                 350         
Leu Ala Lys Ile Lys Gln Lys Cys Pro Leu Tyr Glu Ala Asn Gly Gln 
        355                 360                 365             
Ala Val Pro Lys Glu Lys Asp Glu Met Val Glu Gln Glu Phe Asn Arg 
    370                 375                 380                 
Leu Leu Glu Ala Thr Ser Tyr Leu Ser His Gln Leu Asp Phe Asn Val 
385                 390                 395                 400 
Leu Asn Asn Lys Pro Val Ser Leu Gly Gln Ala Leu Glu Val Val Ile 
                405                 410                 415     
Gln Leu Gln Glu Lys His Val Lys Asp Glu Gln Ile Glu His Trp Lys 
            420                 425                 430         
Lys Ile Val Lys Thr Gln Glu Glu Leu Lys Glu Leu Leu Asn Lys Met 
        435                 440                 445             
Val Asn Leu Lys Glu Lys Ile Lys Glu Leu His Gln Gln Tyr Lys Glu 
    450                 455                 460                 
Ala Ser Glu Val Lys Pro Pro Arg Asp Ile Thr Ala Glu Phe Leu Val 
465                 470                 475                 480 
Lys Ser Lys His Arg Asp Leu Thr Ala Leu Cys Lys Glu Tyr Asp Glu 
                485                 490                 495     
Leu Ala Glu Thr Gln Gly Lys Leu Glu Glu Lys Leu Gln Glu Leu Glu 
            500                 505                 510         
Ala Asn Pro Pro Ser Asp Val Tyr Leu Ser Ser Arg Asp Arg Gln Ile 
        515                 520                 525             
Leu Asp Trp His Phe Ala Asn Leu Glu Phe Ala Asn Ala Thr Pro Leu 
    530                 535                 540                 
Ser Thr Leu Ser Leu Lys His Trp Asp Gln Asp Asp Asp Phe Glu Phe 
545                 550                 555                 560 
Thr Gly Ser His Leu Thr Val Arg Asn Gly Tyr Ser Cys Val Pro Val 
                565                 570                 575     
Ala Leu Ala Glu Gly Leu Asp Ile Lys Leu Asn Thr Ala Val Arg Gln 
            580                 585                 590         
Val Arg Tyr Thr Ala Ser Gly Cys Glu Val Ile Ala Val Asn Thr Arg 
        595                 600                 605             
Ser Thr Ser Gln Thr Phe Ile Tyr Lys Cys Asp Ala Val Leu Cys Thr 
    610                 615                 620                 
Leu Pro Leu Gly Val Leu Lys Gln Gln Pro Pro Ala Val Gln Phe Val 
625                 630                 635                 640 
Pro Pro Leu Pro Glu Trp Lys Thr Ser Ala Val Gln Arg Met Gly Phe 
                645                 650                 655     
Gly Asn Leu Asn Lys Val Val Leu Cys Phe Asp Arg Val Phe Trp Asp 
            660                 665                 670         
Pro Ser Val Asn Leu Phe Gly His Val Gly Ser Thr Thr Ala Ser Arg 
        675                 680                 685             
Gly Glu Leu Phe Leu Phe Trp Asn Leu Tyr Lys Ala Pro Ile Leu Leu 
    690                 695                 700                 
Ala Leu Val Ala Gly Glu Ala Ala Gly Ile Met Glu Asn Ile Ser Asp 
705                 710                 715                 720 
Asp Val Ile Val Gly Arg Cys Leu Ala Ile Leu Lys Gly Ile Phe Gly 
                725                 730                 735     
Ser Ser Ala Val Pro Gln Pro Lys Glu Thr Val Val Ser Arg Trp Arg 
            740                 745                 750         
Ala Asp Pro Trp Ala Arg Gly Ser Tyr Ser Tyr Val Ala Ala Gly Ser 
        755                 760                 765             
Ser Gly Asn Asp Tyr Asp Leu Met Ala Gln Pro Ile Thr Pro Gly Pro 
    770                 775                 780                 
Ser Ile Pro Gly Ala Pro Gln Pro Ile Pro Arg Leu Phe Phe Ala Gly 
785                 790                 795                 800 
Glu His Thr Ile Arg Asn Tyr Pro Ala Thr Val His Gly Ala Leu Leu 
                805                 810                 815     
Ser Gly Leu Arg Glu Ala Gly Arg Ile Ala Asp Gln Phe Leu Gly Ala 
            820                 825                 830         
Met Tyr Thr Leu Pro Arg Gln Ala Thr Pro Gly Val Pro Ala Gln Gln 
        835                 840                 845             
Ser Pro Ser Met 
    850         

<210> 2
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> Epitope of mAb825

<400> 2
Ala Met Tyr Thr Leu Pro Arg Gln Ala Thr Pro Gly Val Pro Ala Gln 
1               5                   10                  15      



