                         SEQUENCE LISTING

<110>  Immatics Biotechnologies GmbH
 
<120>  TRANSFECTED T-CELLS AND T-CELL RECEPTORS FOR USE IN IMMUNOTHERAPY
        AGAINST CANCERS

<130>  I32956WO

<150>  GB1604494.3
<151>  2016-03-16

<150>  US 62/308,970
<151>  2016-03-16

<160>  45    

<170>  PatentIn version 3.5

<210>  1
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  1

Lys Ile Gln Glu Ile Leu Thr Gln Val 
1               5                   


<210>  2
<211>  271
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Lys Thr Phe Ala Gly Phe Ser Phe Leu Phe Leu Trp Leu Gln Leu 
1               5                   10                  15      


Asp Cys Met Ser Arg Gly Glu Asp Val Glu Gln Ser Leu Phe Leu Ser 
            20                  25                  30          


Val Arg Glu Gly Asp Ser Ser Val Ile Asn Cys Thr Tyr Thr Asp Ser 
        35                  40                  45              


Ser Ser Thr Tyr Leu Tyr Trp Tyr Lys Gln Glu Pro Gly Ala Gly Leu 
    50                  55                  60                  


Gln Leu Leu Thr Tyr Ile Phe Ser Asn Met Asp Met Lys Gln Asp Gln 
65                  70                  75                  80  


Arg Leu Thr Val Leu Leu Asn Lys Lys Asp Lys His Leu Ser Leu Arg 
                85                  90                  95      


Ile Ala Asp Thr Gln Thr Gly Asp Ser Ala Ile Tyr Phe Cys Ala Glu 
            100                 105                 110         


Ser Lys Glu Thr Arg Leu Met Phe Gly Asp Gly Thr Gln Leu Val Val 
        115                 120                 125             


Lys Pro Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp 
    130                 135                 140                 


Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser 
145                 150                 155                 160 


Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp 
                165                 170                 175     


Lys Thr Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala 
            180                 185                 190         


Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn 
        195                 200                 205             


Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser 
    210                 215                 220                 


Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn Leu 
225                 230                 235                 240 


Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu Lys 
                245                 250                 255     


Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265                 270     


<210>  3
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Lys Thr Phe Ala Gly Phe Ser Phe Leu Phe Leu Trp Leu Gln Leu 
1               5                   10                  15      


Asp Cys Met Ser Arg 
            20      


<210>  4
<211>  113
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Lys Thr Phe Ala Gly Phe Ser Phe Leu Phe Leu Trp Leu Gln Leu 
1               5                   10                  15      


Asp Cys Met Ser Arg Gly Glu Asp Val Glu Gln Ser Leu Phe Leu Ser 
            20                  25                  30          


Val Arg Glu Gly Asp Ser Ser Val Ile Asn Cys Thr Tyr Thr Asp Ser 
        35                  40                  45              


Ser Ser Thr Tyr Leu Tyr Trp Tyr Lys Gln Glu Pro Gly Ala Gly Leu 
    50                  55                  60                  


Gln Leu Leu Thr Tyr Ile Phe Ser Asn Met Asp Met Lys Gln Asp Gln 
65                  70                  75                  80  


Arg Leu Thr Val Leu Leu Asn Lys Lys Asp Lys His Leu Ser Leu Arg 
                85                  90                  95      


Ile Ala Asp Thr Gln Thr Gly Asp Ser Ala Ile Tyr Phe Cys Ala Glu 
            100                 105                 110         


Ser 
    


<210>  5
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  5

Asp Ser Ser Ser Thr Tyr 
1               5       


<210>  6
<211>  3
<212>  PRT
<213>  Homo sapiens

<400>  6

Ile Phe Ser 
1           


<210>  7
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  7

Cys Ala Glu Ser Lys Glu Thr Arg Leu Met Phe 
1               5                   10      


<210>  8
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  8

Arg Leu Met Phe Gly Asp Gly Thr Gln Leu Val Val Lys Pro 
1               5                   10                  


<210>  9
<211>  141
<212>  PRT
<213>  Homo sapiens

<400>  9

Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser Lys 
1               5                   10                  15      


Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Gln Thr 
            20                  25                  30          


Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys Thr 
        35                  40                  45              


Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala Val Ala 
    50                  55                  60                  


Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn Ser 
65                  70                  75                  80  


Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser Cys Asp 
                85                  90                  95      


Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn Leu Asn Phe 
            100                 105                 110         


Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu Lys Val Ala 
        115                 120                 125             


Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
    130                 135                 140     


<210>  10
<211>  318
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Leu Leu Leu Leu Leu Leu Leu Gly Pro Gly Ile Ser Leu Leu Leu 
1               5                   10                  15      


Pro Gly Ser Leu Ala Gly Ser Gly Leu Gly Ala Val Val Ser Gln His 
            20                  25                  30          


Pro Ser Trp Val Ile Cys Lys Ser Gly Thr Ser Val Lys Ile Glu Cys 
        35                  40                  45              


Arg Ser Leu Asp Phe Gln Ala Thr Thr Met Phe Trp Tyr Arg Gln Phe 
    50                  55                  60                  


Pro Lys Gln Ser Leu Met Leu Met Ala Thr Ser Asn Glu Gly Ser Lys 
65                  70                  75                  80  


Ala Thr Tyr Glu Gln Gly Val Glu Lys Asp Lys Phe Leu Ile Asn His 
                85                  90                  95      


Ala Ser Leu Thr Leu Ser Thr Leu Thr Val Thr Ser Ala His Pro Glu 
            100                 105                 110         


Asp Ser Ser Phe Tyr Ile Cys Ser Ala Arg Ala Gly Gly His Glu Gln 
        115                 120                 125             


Phe Phe Gly Pro Gly Thr Arg Leu Thr Val Leu Glu Asp Leu Lys Asn 
    130                 135                 140                 


Val Phe Pro Pro Glu Val Ala Val Phe Glu Pro Ser Glu Ala Glu Ile 
145                 150                 155                 160 


Ser His Thr Gln Lys Ala Thr Leu Val Cys Leu Ala Thr Gly Phe Tyr 
                165                 170                 175     


Pro Asp His Val Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val His 
            180                 185                 190         


Ser Gly Val Ser Thr Asp Pro Gln Pro Leu Lys Glu Gln Pro Ala Leu 
        195                 200                 205             


Asn Asp Ser Arg Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr 
    210                 215                 220                 


Phe Trp Gln Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe Tyr 
225                 230                 235                 240 


Gly Leu Ser Glu Asn Asp Glu Trp Thr Gln Asp Arg Ala Lys Pro Val 
                245                 250                 255     


Thr Gln Ile Val Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Phe 
            260                 265                 270         


Thr Ser Glu Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr 
        275                 280                 285             


Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Ala 
    290                 295                 300                 


Leu Val Leu Met Ala Met Val Lys Arg Lys Asp Ser Arg Gly 
305                 310                 315             


<210>  11
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Leu Leu Leu Leu Leu Leu Leu Gly Pro Gly Ile Ser Leu Leu Leu 
1               5                   10                  15      


Pro Gly Ser Leu Ala Gly Ser Gly Leu 
            20                  25  


<210>  12
<211>  122
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Leu Leu Leu Leu Leu Leu Leu Gly Pro Gly Ile Ser Leu Leu Leu 
1               5                   10                  15      


Pro Gly Ser Leu Ala Gly Ser Gly Leu Gly Ala Val Val Ser Gln His 
            20                  25                  30          


Pro Ser Trp Val Ile Cys Lys Ser Gly Thr Ser Val Lys Ile Glu Cys 
        35                  40                  45              


Arg Ser Leu Asp Phe Gln Ala Thr Thr Met Phe Trp Tyr Arg Gln Phe 
    50                  55                  60                  


Pro Lys Gln Ser Leu Met Leu Met Ala Thr Ser Asn Glu Gly Ser Lys 
65                  70                  75                  80  


Ala Thr Tyr Glu Gln Gly Val Glu Lys Asp Lys Phe Leu Ile Asn His 
                85                  90                  95      


Ala Ser Leu Thr Leu Ser Thr Leu Thr Val Thr Ser Ala His Pro Glu 
            100                 105                 110         


Asp Ser Ser Phe Tyr Ile Cys Ser Ala Arg 
        115                 120         


<210>  13
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  13

Asp Phe Gln Ala Thr Thr 
1               5       


<210>  14
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  14

Ser Asn Glu Gly Ser Lys Ala 
1               5           


<210>  15
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  15

Cys Ser Ala Arg Ala Gly Gly His Glu Gln Phe Phe 
1               5                   10          


<210>  16
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  16

Glu Gln Phe Phe Gly Pro Gly Thr Arg Leu Thr Val Leu 
1               5                   10              


<210>  17
<211>  179
<212>  PRT
<213>  Homo sapiens

<400>  17

Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala Val Phe Glu Pro 
1               5                   10                  15      


Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu Val Cys Leu 
            20                  25                  30          


Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser Trp Trp Val Asn 
        35                  40                  45              


Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln Pro Leu Lys 
    50                  55                  60                  


Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser Ser Arg Leu 
65                  70                  75                  80  


Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His Phe Arg Cys 
                85                  90                  95      


Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp Thr Gln Asp 
            100                 105                 110         


Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala Trp Gly Arg 
        115                 120                 125             


Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln Gln Gly Val Leu Ser 
    130                 135                 140                 


Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala 
145                 150                 155                 160 


Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val Lys Arg Lys Asp 
                165                 170                 175     


Ser Arg Gly 
            


<210>  18
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  18

Val Ile Gly Phe Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu 
1               5                   10                  15      


Leu Met Thr Leu 
            20  


<210>  19
<211>  23
<212>  PRT
<213>  Homo sapiens

<400>  19

Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val 
1               5                   10                  15      


Leu Val Ser Ala Leu Val Leu 
            20              


<210>  20
<211>  274
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Glu Thr Leu Leu Gly Leu Leu Ile Leu Trp Leu Gln Leu Gln Trp 
1               5                   10                  15      


Val Ser Ser Lys Gln Glu Val Thr Gln Ile Pro Ala Ala Leu Ser Val 
            20                  25                  30          


Pro Glu Gly Glu Asn Leu Val Leu Asn Cys Ser Phe Thr Asp Ser Ala 
        35                  40                  45              


Ile Tyr Asn Leu Gln Trp Phe Arg Gln Asp Pro Gly Lys Gly Leu Thr 
    50                  55                  60                  


Ser Leu Leu Leu Ile Gln Ser Ser Gln Arg Glu Gln Thr Ser Gly Arg 
65                  70                  75                  80  


Leu Asn Ala Ser Leu Asp Lys Ser Ser Gly Arg Ser Thr Leu Tyr Ile 
                85                  90                  95      


Ala Ala Ser Gln Pro Gly Asp Ser Ala Thr Tyr Leu Cys Ala Val Arg 
            100                 105                 110         


Pro Thr Ser Gly Gly Ser Tyr Ile Pro Thr Phe Gly Arg Gly Thr Ser 
        115                 120                 125             


Leu Ile Val His Pro Tyr Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln 
    130                 135                 140                 


Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp 
145                 150                 155                 160 


Phe Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr 
                165                 170                 175     


Ile Thr Asp Lys Thr Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser 
            180                 185                 190         


Asn Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn 
        195                 200                 205             


Ala Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro 
    210                 215                 220                 


Glu Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp 
225                 230                 235                 240 


Thr Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu 
                245                 250                 255     


Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp 
            260                 265                 270         


Ser Ser 
        


<210>  21
<211>  311
<212>  PRT
<213>  Homo sapiens

<400>  21

Met Ser Ile Gly Leu Leu Cys Cys Ala Ala Leu Ser Leu Leu Trp Ala 
1               5                   10                  15      


Gly Pro Val Asn Ala Gly Val Thr Gln Thr Pro Lys Phe Gln Val Leu 
            20                  25                  30          


Lys Thr Gly Gln Ser Met Thr Leu Gln Cys Ala Gln Asp Met Asn His 
        35                  40                  45              


Glu Tyr Met Ser Trp Tyr Arg Gln Asp Pro Gly Met Gly Leu Arg Leu 
    50                  55                  60                  


Ile His Tyr Ser Val Gly Ala Gly Ile Thr Asp Gln Gly Glu Val Pro 
65                  70                  75                  80  


Asn Gly Tyr Asn Val Ser Arg Ser Thr Thr Glu Asp Phe Pro Leu Arg 
                85                  90                  95      


Leu Leu Ser Ala Ala Pro Ser Gln Thr Ser Val Tyr Phe Cys Ala Ser 
            100                 105                 110         


Ser Tyr Val Gly Asn Thr Gly Glu Leu Phe Phe Gly Glu Gly Ser Arg 
        115                 120                 125             


Leu Thr Val Leu Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala 
    130                 135                 140                 


Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr 
145                 150                 155                 160 


Leu Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser 
                165                 170                 175     


Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro 
            180                 185                 190         


Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu 
        195                 200                 205             


Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn 
    210                 215                 220                 


His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu 
225                 230                 235                 240 


Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu 
                245                 250                 255     


Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln Gln 
            260                 265                 270         


Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala 
        275                 280                 285             


Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val 
    290                 295                 300                 


Lys Arg Lys Asp Ser Arg Gly 
305                 310     


<210>  22
<211>  36
<212>  DNA
<213>  Homo sapiens

<400>  22
ggaattccat atgagtcaac aaggagaaga agatcc                                 36


<210>  23
<211>  36
<212>  DNA
<213>  Homo sapiens

<400>  23
ttgtcagtcg acttagagtc tctcagctgg tacacg                                 36


<210>  24
<211>  36
<212>  DNA
<213>  Homo sapiens

<400>  24
tctctcatat ggatggtgga attactcaat ccccaa                                 36


<210>  25
<211>  32
<212>  DNA
<213>  Homo sapiens

<400>  25
tagaaaccgg tggccaggca caccagtgtg gc                                     32


<210>  26
<211>  0
<212>  PRT
<213>  Homo sapiens

<400>  26
000
<210>  27
<211>  0
<212>  PRT
<213>  Homo sapiens

<400>  27
000
<210>  28
<211>  0
<212>  PRT
<213>  Homo sapiens

<400>  28
000
<210>  29
<211>  0
<212>  PRT
<213>  Homo sapiens

<400>  29
000
<210>  30
<211>  0
<212>  PRT
<213>  Homo sapiens

<400>  30
000
<210>  31
<211>  0
<212>  PRT
<213>  Homo sapiens

<400>  31
000
<210>  32
<211>  0
<212>  PRT
<213>  Homo sapiens

<400>  32
000
<210>  33
<211>  0
<212>  PRT
<213>  Homo sapiens

<400>  33
000
<210>  34
<211>  0
<212>  PRT
<213>  Homo sapiens

<400>  34
000
<210>  35
<211>  0
<212>  PRT
<213>  Homo sapiens

<400>  35
000
<210>  36
<211>  0
<212>  PRT
<213>  Homo sapiens

<400>  36
000
<210>  37
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  37

Ala Ile Gln Glu Ile Leu Thr Gln Val 
1               5                   


<210>  38
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  38

Lys Ala Gln Glu Ile Leu Thr Gln Val 
1               5                   


<210>  39
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  39

Lys Ile Ala Glu Ile Leu Thr Gln Val 
1               5                   


<210>  40
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  40

Lys Ile Gln Ala Ile Leu Thr Gln Val 
1               5                   


<210>  41
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  41

Lys Ile Gln Glu Ala Leu Thr Gln Val 
1               5                   


<210>  42
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  42

Lys Ile Gln Glu Ile Ala Thr Gln Val 
1               5                   


<210>  43
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  43

Lys Ile Gln Glu Ile Leu Ala Gln Val 
1               5                   


<210>  44
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  44

Lys Ile Gln Glu Ile Leu Thr Ala Val 
1               5                   


<210>  45
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  45

Lys Ile Gln Glu Ile Leu Thr Gln Ala 
1               5                   





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