                         SEQUENCE LISTING

<110>  UNIVERSITE PARIS EST CRETEIL VAL DE MARNE
       ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS
 
<120>  ALZHEIMER'S DISEASE EARLY DIAGNOSIS AND/OR PROGNOSIS IN 
       CIRCULATING IMMUNE CELLS BASED ON HEPARAN SULFATES AND/OR OF 
       HEPARAN SULFATE SULFOTRANSFERASES

<130>  B372122D36033

<150>  EP16305285.5
<151>  2016-03-15

<160>  7     

<170>  PatentIn version 3.5

<210>  1
<211>  307
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ala Ala Leu Leu Leu Gly Ala Val Leu Leu Val Ala Gln Pro Gln 
1               5                   10                  15      


Leu Val Pro Ser Arg Thr Ala Glu Leu Gly Gln Gln Glu Leu Leu Arg 
            20                  25                  30          


Lys Ala Gly Thr Leu Gln Asp Asp Val Arg Asp Gly Val Ala Pro Asn 
        35                  40                  45              


Gly Ser Ala Gln Gln Leu Pro Gln Thr Ile Ile Ile Gly Val Arg Lys 
    50                  55                  60                  


Gly Gly Thr Arg Ala Leu Leu Glu Met Leu Ser Leu His Pro Asp Val 
65                  70                  75                  80  


Ala Ala Ala Glu Asn Glu Val His Phe Phe Asp Trp Glu Glu His Tyr 
                85                  90                  95      


Ser His Gly Leu Gly Trp Tyr Leu Ser Gln Met Pro Phe Ser Trp Pro 
            100                 105                 110         


His Gln Leu Thr Val Glu Lys Thr Pro Ala Tyr Phe Thr Ser Pro Lys 
        115                 120                 125             


Val Pro Glu Arg Val Tyr Ser Met Asn Pro Ser Ile Arg Leu Leu Leu 
    130                 135                 140                 


Ile Leu Arg Asp Pro Ser Glu Arg Val Leu Ser Asp Tyr Thr Gln Val 
145                 150                 155                 160 


Phe Tyr Asn His Met Gln Lys His Lys Pro Tyr Pro Ser Ile Glu Glu 
                165                 170                 175     


Phe Leu Val Arg Asp Gly Arg Leu Asn Val Asp Tyr Lys Ala Leu Asn 
            180                 185                 190         


Arg Ser Leu Tyr His Val His Met Gln Asn Trp Leu Arg Phe Phe Pro 
        195                 200                 205             


Leu Arg His Ile His Ile Val Asp Gly Asp Arg Leu Ile Arg Asp Pro 
    210                 215                 220                 


Phe Pro Glu Ile Gln Lys Val Glu Arg Phe Leu Lys Leu Ser Pro Gln 
225                 230                 235                 240 


Ile Asn Ala Ser Asn Phe Tyr Phe Asn Lys Thr Lys Gly Phe Tyr Cys 
                245                 250                 255     


Leu Arg Asp Ser Gly Arg Asp Arg Cys Leu His Glu Ser Lys Gly Arg 
            260                 265                 270         


Ala His Pro Gln Val Asp Pro Lys Leu Leu Asn Lys Leu His Glu Tyr 
        275                 280                 285             


Phe His Glu Pro Asn Lys Lys Phe Phe Glu Leu Val Gly Arg Thr Phe 
    290                 295                 300                 


Asp Trp His 
305         


<210>  2
<211>  367
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ala Tyr Arg Val Leu Gly Arg Ala Gly Pro Pro Gln Pro Arg Arg 
1               5                   10                  15      


Ala Arg Arg Leu Leu Phe Ala Phe Thr Leu Ser Leu Ser Cys Thr Tyr 
            20                  25                  30          


Leu Cys Tyr Ser Phe Leu Cys Cys Cys Asp Asp Leu Gly Arg Ser Arg 
        35                  40                  45              


Leu Leu Gly Ala Pro Arg Cys Leu Arg Gly Pro Ser Ala Gly Gly Gln 
    50                  55                  60                  


Lys Leu Leu Gln Lys Ser Arg Pro Cys Asp Pro Ser Gly Pro Thr Pro 
65                  70                  75                  80  


Ser Glu Pro Ser Ala Pro Ser Ala Pro Ala Ala Ala Val Pro Ala Pro 
                85                  90                  95      


Arg Leu Ser Gly Ser Asn His Ser Gly Ser Pro Lys Leu Gly Thr Lys 
            100                 105                 110         


Arg Leu Pro Gln Ala Leu Ile Val Gly Val Lys Lys Gly Gly Thr Arg 
        115                 120                 125             


Ala Val Leu Glu Phe Ile Arg Val His Pro Asp Val Arg Ala Leu Gly 
    130                 135                 140                 


Thr Glu Pro His Phe Phe Asp Arg Asn Tyr Gly Arg Gly Leu Asp Trp 
145                 150                 155                 160 


Tyr Arg Ser Leu Met Pro Arg Thr Leu Glu Ser Gln Ile Thr Leu Glu 
                165                 170                 175     


Lys Thr Pro Ser Tyr Phe Val Thr Gln Glu Ala Pro Arg Arg Ile Phe 
            180                 185                 190         


Asn Met Ser Arg Asp Thr Lys Leu Ile Val Val Val Arg Asn Pro Val 
        195                 200                 205             


Thr Arg Ala Ile Ser Asp Tyr Thr Gln Thr Leu Ser Lys Lys Pro Asp 
    210                 215                 220                 


Ile Pro Thr Phe Glu Gly Leu Ser Phe Arg Asn Arg Thr Leu Gly Leu 
225                 230                 235                 240 


Val Asp Val Ser Trp Asn Ala Ile Arg Ile Gly Met Tyr Val Leu His 
                245                 250                 255     


Leu Glu Ser Trp Leu Gln Tyr Phe Pro Leu Ala Gln Ile His Phe Val 
            260                 265                 270         


Ser Gly Glu Arg Leu Ile Thr Asp Pro Ala Gly Glu Met Gly Arg Val 
        275                 280                 285             


Gln Asp Phe Leu Gly Ile Lys Arg Phe Ile Thr Asp Lys His Phe Tyr 
    290                 295                 300                 


Phe Asn Lys Thr Lys Gly Phe Pro Cys Leu Lys Lys Thr Glu Ser Ser 
305                 310                 315                 320 


Leu Leu Pro Arg Cys Leu Gly Lys Ser Lys Gly Arg Thr His Val Gln 
                325                 330                 335     


Ile Asp Pro Glu Val Ile Asp Gln Leu Arg Glu Phe Tyr Arg Pro Tyr 
            340                 345                 350         


Asn Ile Lys Phe Tyr Glu Thr Val Gly Gln Asp Phe Arg Trp Glu 
        355                 360                 365         


<210>  3
<211>  393
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Ala Pro Ser Gly Pro Thr Gly Ala Gln Pro Ser Pro Ala Glu Pro 
1               5                   10                  15      


Leu Ser Arg Ser Ile Phe Arg Lys Phe Leu Leu Met Leu Cys Ser Leu 
            20                  25                  30          


Leu Thr Ser Leu Tyr Val Phe Tyr Cys Leu Ala Glu Arg Cys Pro Pro 
        35                  40                  45              


Gly Ser Gly Pro Val Ala Gly Val Pro Gly Arg Gly Val Pro Ala Gly 
    50                  55                  60                  


Pro Arg Glu Leu Ala Met Trp Pro Ala Gly Ala Pro Arg Lys Arg Leu 
65                  70                  75                  80  


Leu Gln Leu Arg Gln Arg Arg Arg Arg Gly Arg Ser Gly Pro Gly Asp 
                85                  90                  95      


Ser Ser Asp Gln Glu Glu Gln Ser Pro Gly Leu Ala Ala Ala Pro Gly 
            100                 105                 110         


Gly Ser Gly Ala Gly Ser Ser Val Ala Glu Ala Gln Pro Gly Thr Leu 
        115                 120                 125             


Ala Leu Leu Leu Asp Glu Gly Ser Lys Gln Leu Pro Gln Ala Ile Ile 
    130                 135                 140                 


Ile Gly Val Lys Lys Gly Gly Thr Arg Ala Leu Leu Glu Phe Leu Arg 
145                 150                 155                 160 


Val His Pro Asp Val Arg Ala Val Gly Ala Glu Pro His Phe Phe Asp 
                165                 170                 175     


Arg Ser Tyr His Lys Gly Leu Ala Trp Tyr Arg Asp Leu Met Pro Arg 
            180                 185                 190         


Thr Leu Glu Gly Gln Ile Thr Met Glu Lys Thr Pro Ser Tyr Phe Val 
        195                 200                 205             


Thr Arg Glu Ala Pro Ala Arg Ile Ser Ala Met Ser Lys Asp Thr Lys 
    210                 215                 220                 


Leu Ile Val Val Val Arg Asp Pro Val Thr Arg Ala Ile Ser Asp Tyr 
225                 230                 235                 240 


Thr Gln Thr Leu Ser Lys Arg Pro Asp Ile Pro Ser Phe Glu Ser Leu 
                245                 250                 255     


Thr Phe Arg Asn Arg Ser Ala Gly Leu Ile Asp Thr Ser Trp Ser Ala 
            260                 265                 270         


Ile Gln Ile Gly Leu Tyr Ala Lys His Leu Glu Pro Trp Leu Arg His 
        275                 280                 285             


Phe Pro Leu Gly Gln Met Leu Phe Val Ser Gly Glu Arg Leu Val Ser 
    290                 295                 300                 


Asp Pro Ala Gly Glu Leu Arg Arg Val Gln Asp Phe Leu Gly Leu Lys 
305                 310                 315                 320 


Arg Ile Ile Thr Asp Lys His Phe Tyr Phe Asn Gln Thr Lys Gly Phe 
                325                 330                 335     


Pro Cys Leu Lys Lys Ala Glu Gly Ser Gly Lys Pro His Cys Leu Gly 
            340                 345                 350         


Lys Thr Lys Gly Arg Ala His Pro Thr Ile Ala Arg Glu Val Leu Arg 
        355                 360                 365             


Gln Leu Arg Asp Phe Tyr Arg Pro Phe Asn Arg Lys Phe Tyr Gln Met 
    370                 375                 380                 


Thr Gly Arg Asp Phe Gly Trp Asp Gly 
385                 390             


<210>  4
<211>  390
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Gly Gln Arg Leu Ser Gly Gly Arg Ser Cys Leu Asp Val Pro Gly 
1               5                   10                  15      


Arg Leu Leu Pro Gln Pro Pro Pro Pro Pro Pro Pro Val Arg Arg Lys 
            20                  25                  30          


Leu Ala Leu Leu Phe Ala Met Leu Cys Val Trp Leu Tyr Met Phe Leu 
        35                  40                  45              


Tyr Ser Cys Ala Gly Ser Cys Ala Ala Ala Pro Gly Leu Leu Leu Leu 
    50                  55                  60                  


Gly Ser Gly Ser Arg Ala Ala His Asp Pro Pro Ala Leu Ala Thr Ala 
65                  70                  75                  80  


Pro Asp Gly Thr Pro Pro Arg Leu Pro Phe Arg Ala Pro Pro Ala Thr 
                85                  90                  95      


Pro Leu Ala Ser Gly Lys Glu Met Ala Glu Gly Ala Ala Ser Pro Glu 
            100                 105                 110         


Glu Gln Ser Pro Glu Val Pro Asp Ser Pro Ser Pro Ile Ser Ser Phe 
        115                 120                 125             


Phe Ser Gly Ser Gly Ser Lys Gln Leu Pro Gln Ala Ile Ile Ile Gly 
    130                 135                 140                 


Val Lys Lys Gly Gly Thr Arg Ala Leu Leu Glu Phe Leu Arg Val His 
145                 150                 155                 160 


Pro Asp Val Arg Ala Val Gly Ala Glu Pro His Phe Phe Asp Arg Ser 
                165                 170                 175     


Tyr Asp Lys Gly Leu Ala Trp Tyr Arg Asp Leu Met Pro Arg Thr Leu 
            180                 185                 190         


Asp Gly Gln Ile Thr Met Glu Lys Thr Pro Ser Tyr Phe Val Thr Arg 
        195                 200                 205             


Glu Ala Pro Ala Arg Ile Ser Ala Met Ser Lys Asp Thr Lys Leu Ile 
    210                 215                 220                 


Val Val Val Arg Asp Pro Val Thr Arg Ala Ile Ser Asp Tyr Thr Gln 
225                 230                 235                 240 


Thr Leu Ser Lys Arg Pro Asp Ile Pro Thr Phe Glu Ser Leu Thr Phe 
                245                 250                 255     


Lys Asn Arg Thr Ala Gly Leu Ile Asp Thr Ser Trp Ser Ala Ile Gln 
            260                 265                 270         


Ile Gly Ile Tyr Ala Lys His Leu Glu His Trp Leu Arg His Phe Pro 
        275                 280                 285             


Ile Arg Gln Met Leu Phe Val Ser Gly Glu Arg Leu Ile Ser Asp Pro 
    290                 295                 300                 


Ala Gly Glu Leu Gly Arg Val Gln Asp Phe Leu Gly Leu Lys Arg Ile 
305                 310                 315                 320 


Ile Thr Asp Lys His Phe Tyr Phe Asn Lys Thr Lys Gly Phe Pro Cys 
                325                 330                 335     


Leu Lys Lys Ala Glu Gly Ser Ser Arg Pro His Cys Leu Gly Lys Thr 
            340                 345                 350         


Lys Gly Arg Thr His Pro Glu Ile Asp Arg Glu Val Val Arg Arg Leu 
        355                 360                 365             


Arg Glu Phe Tyr Arg Pro Phe Asn Leu Lys Phe Tyr Gln Met Thr Gly 
    370                 375                 380                 


His Asp Phe Gly Trp Asp 
385                 390 


<210>  5
<211>  456
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Ala Arg Trp Pro Ala Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro 
1               5                   10                  15      


Leu Ala Ala Pro Pro Pro Pro Gly Ala Ser Ala Lys Gly Pro Pro Ala 
            20                  25                  30          


Arg Lys Leu Leu Phe Met Cys Thr Leu Ser Leu Ser Val Thr Tyr Leu 
        35                  40                  45              


Cys Tyr Ser Leu Leu Gly Gly Ser Gly Ser Leu Gln Phe Pro Leu Ala 
    50                  55                  60                  


Leu Gln Glu Ser Pro Gly Ala Ala Ala Glu Pro Pro Pro Ser Pro Pro 
65                  70                  75                  80  


Pro Pro Ser Leu Leu Pro Thr Pro Val Arg Leu Gly Ala Pro Ser Gln 
                85                  90                  95      


Pro Pro Ala Pro Pro Pro Leu Asp Asn Ala Ser His Gly Glu Pro Pro 
            100                 105                 110         


Glu Pro Pro Glu Gln Pro Ala Ala Pro Gly Thr Asp Gly Trp Gly Leu 
        115                 120                 125             


Pro Ser Gly Gly Gly Gly Ala Arg Asp Ala Trp Leu Arg Thr Pro Leu 
    130                 135                 140                 


Ala Pro Ser Glu Met Ile Thr Ala Gln Ser Ala Leu Pro Glu Arg Glu 
145                 150                 155                 160 


Ala Gln Glu Ser Ser Thr Thr Asp Glu Asp Leu Ala Gly Arg Arg Ala 
                165                 170                 175     


Ala Asn Gly Ser Ser Glu Arg Gly Gly Ala Val Ser Thr Pro Asp Tyr 
            180                 185                 190         


Gly Glu Lys Lys Leu Pro Gln Ala Leu Ile Ile Gly Val Lys Lys Gly 
        195                 200                 205             


Gly Thr Arg Ala Leu Leu Glu Ala Ile Arg Val His Pro Asp Val Arg 
    210                 215                 220                 


Ala Val Gly Val Glu Pro His Phe Phe Asp Arg Asn Tyr Glu Lys Gly 
225                 230                 235                 240 


Leu Glu Trp Tyr Arg Asn Val Met Pro Lys Thr Leu Asp Gly Gln Ile 
                245                 250                 255     


Thr Met Glu Lys Thr Pro Ser Tyr Phe Val Thr Asn Glu Ala Pro Lys 
            260                 265                 270         


Arg Ile His Ser Met Ala Lys Asp Ile Lys Leu Ile Val Val Val Arg 
        275                 280                 285             


Asn Pro Val Thr Arg Ala Ile Ser Asp Tyr Thr Gln Thr Leu Ser Lys 
    290                 295                 300                 


Lys Pro Glu Ile Pro Thr Phe Glu Val Leu Ala Phe Lys Asn Arg Thr 
305                 310                 315                 320 


Leu Gly Leu Ile Asp Ala Ser Trp Ser Ala Ile Arg Ile Gly Ile Tyr 
                325                 330                 335     


Ala Leu His Leu Glu Asn Trp Leu Gln Tyr Phe Pro Leu Ser Gln Ile 
            340                 345                 350         


Leu Phe Val Ser Gly Glu Arg Leu Ile Val Asp Pro Ala Gly Glu Met 
        355                 360                 365             


Ala Lys Val Gln Asp Phe Leu Gly Leu Lys Arg Val Val Thr Lys Lys 
    370                 375                 380                 


His Phe Tyr Phe Asn Lys Thr Lys Gly Phe Pro Cys Leu Lys Lys Pro 
385                 390                 395                 400 


Glu Asp Ser Ser Ala Pro Arg Cys Leu Gly Lys Ser Lys Gly Arg Thr 
                405                 410                 415     


His Pro Arg Ile Asp Pro Asp Val Ile His Arg Leu Arg Lys Phe Tyr 
            420                 425                 430         


Lys Pro Phe Asn Leu Met Phe Tyr Gln Met Thr Gly Gln Asp Phe Gln 
        435                 440                 445             


Trp Glu Gln Glu Glu Gly Asp Lys 
    450                 455     


<210>  6
<211>  346
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Leu Phe Lys Gln Gln Ala Trp Leu Arg Gln Lys Leu Leu Val Leu 
1               5                   10                  15      


Gly Ser Leu Ala Val Gly Ser Leu Leu Tyr Leu Val Ala Arg Val Gly 
            20                  25                  30          


Ser Leu Asp Arg Leu Gln Pro Ile Cys Pro Ile Glu Gly Arg Leu Gly 
        35                  40                  45              


Gly Ala Arg Thr Gln Ala Glu Phe Pro Leu Arg Ala Leu Gln Phe Lys 
    50                  55                  60                  


Arg Gly Leu Leu His Glu Phe Arg Lys Gly Asn Ala Ser Lys Glu Gln 
65                  70                  75                  80  


Val Arg Leu His Asp Leu Val Gln Gln Leu Pro Lys Ala Ile Ile Ile 
                85                  90                  95      


Gly Val Arg Lys Gly Gly Thr Arg Ala Leu Leu Glu Met Leu Asn Leu 
            100                 105                 110         


His Pro Ala Val Val Lys Ala Ser Gln Glu Ile His Phe Phe Asp Asn 
        115                 120                 125             


Asp Glu Asn Tyr Gly Lys Gly Ile Glu Trp Tyr Arg Lys Lys Met Pro 
    130                 135                 140                 


Phe Ser Tyr Pro Gln Gln Ile Thr Ile Glu Lys Ser Pro Ala Tyr Phe 
145                 150                 155                 160 


Ile Thr Glu Glu Val Pro Glu Arg Ile Tyr Lys Met Asn Ser Ser Ile 
                165                 170                 175     


Lys Leu Leu Ile Ile Val Arg Glu Pro Thr Thr Arg Ala Ile Ser Asp 
            180                 185                 190         


Tyr Thr Gln Val Leu Glu Gly Lys Glu Arg Lys Asn Lys Thr Tyr Tyr 
        195                 200                 205             


Lys Phe Glu Lys Leu Ala Ile Asp Pro Asn Thr Cys Glu Val Asn Thr 
    210                 215                 220                 


Lys Tyr Lys Ala Val Arg Thr Ser Ile Tyr Thr Lys His Leu Glu Arg 
225                 230                 235                 240 


Trp Leu Lys Tyr Phe Pro Ile Glu Gln Phe His Val Val Asp Gly Asp 
                245                 250                 255     


Arg Leu Ile Thr Glu Pro Leu Pro Glu Leu Gln Leu Val Glu Lys Phe 
            260                 265                 270         


Leu Asn Leu Pro Pro Arg Ile Ser Gln Tyr Asn Leu Tyr Phe Asn Ala 
        275                 280                 285             


Thr Arg Gly Phe Tyr Cys Leu Arg Phe Asn Ile Ile Phe Asn Lys Cys 
    290                 295                 300                 


Leu Ala Gly Ser Lys Gly Arg Ile His Pro Glu Val Asp Pro Ser Val 
305                 310                 315                 320 


Ile Thr Lys Leu Arg Lys Phe Phe His Pro Phe Asn Gln Lys Phe Tyr 
                325                 330                 335     


Gln Ile Thr Gly Arg Thr Leu Asn Trp Pro 
            340                 345     


<210>  7
<211>  341
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Ala Gly Ser Gly Gly Leu Gly Gly Gly Ala Gly Gly Gly Gln Gly 
1               5                   10                  15      


Ala Gly Ala Gly Gln Gly Ala Ala Leu Arg Ala Ser Arg Ala Pro Met 
            20                  25                  30          


Leu Leu Val Ala Leu Val Leu Gly Ala Tyr Cys Leu Cys Ala Leu Pro 
        35                  40                  45              


Gly Arg Cys Pro Pro Ala Ala Arg Ala Pro Ala Pro Ala Pro Ala Pro 
    50                  55                  60                  


Ser Glu Pro Ser Ser Val His Arg Pro Gly Ala Pro Gly Leu Pro Leu 
65                  70                  75                  80  


Ala Ser Gly Pro Gly Arg Arg Arg Phe Pro Gln Ala Leu Ile Val Gly 
                85                  90                  95      


Val Lys Lys Gly Gly Thr Arg Ala Leu Leu Glu Phe Leu Arg Leu His 
            100                 105                 110         


Pro Asp Val Arg Ala Leu Gly Ser Glu Pro His Phe Phe Asp Arg Cys 
        115                 120                 125             


Tyr Glu Arg Gly Leu Ala Trp Tyr Arg Ser Leu Met Pro Arg Thr Leu 
    130                 135                 140                 


Asp Gly Gln Ile Thr Met Glu Lys Thr Pro Ser Tyr Phe Val Thr Arg 
145                 150                 155                 160 


Glu Ala Pro Arg Arg Ile His Ala Met Ser Pro Asp Thr Lys Leu Ile 
                165                 170                 175     


Val Val Val Arg Asn Pro Val Thr Arg Ala Ile Ser Asp Tyr Ala Gln 
            180                 185                 190         


Thr Leu Ser Lys Thr Pro Gly Leu Pro Ser Phe Arg Ala Leu Ala Phe 
        195                 200                 205             


Arg His Gly Leu Gly Pro Val Asp Thr Ala Trp Ser Ala Val Arg Ile 
    210                 215                 220                 


Gly Leu Tyr Ala Gln His Leu Asp His Trp Leu Arg Tyr Phe Pro Leu 
225                 230                 235                 240 


Ser His Phe Leu Phe Val Ser Gly Glu Arg Leu Val Ser Asp Pro Ala 
                245                 250                 255     


Gly Glu Val Gly Arg Val Gln Asp Phe Leu Gly Leu Lys Arg Val Val 
            260                 265                 270         


Thr Asp Lys His Phe Tyr Phe Asn Ala Thr Lys Gly Phe Pro Cys Leu 
        275                 280                 285             


Lys Lys Ala Gln Gly Gly Ser Arg Pro Arg Cys Leu Gly Lys Ser Lys 
    290                 295                 300                 


Gly Arg Pro His Pro Arg Val Pro Gln Ala Leu Val Arg Arg Leu Gln 
305                 310                 315                 320 


Glu Phe Tyr Arg Pro Phe Asn Arg Arg Phe Tyr Gln Met Thr Gly Gln 
                325                 330                 335     


Asp Phe Gly Trp Gly 
            340     


