                         SEQUENCE LISTING

<110>  Amal Therapeutics SA, Geneva, Switzerland
 
<120>  COMBINATION OF AN IMMUNE CHECKPOINT MODULATOR AND A COMPLEX 
       COMPRISING A CELL PENETRATING PEPTIDE, A CARGO AND A TLR PEPTIDE 
       AGONIST FOR USE IN MEDICINE

<130>  AM05P007WO2

<150>  PCT/EP2016/000472
<151>  2016-03-16

<150>  PCT/EP2016/070264
<151>  2016-08-26

<160>  47    

<170>  PatentIn version 3.5

<210>  1
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CPP: Penetratin

<400>  1

Arg Gln Ile Lys Ile Tyr Phe Gln Asn Arg Arg Met Lys Trp Lys Lys 
1               5                   10                  15      


<210>  2
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CPP: TAT minimal domain

<400>  2

Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg 
1               5                   10      


<210>  3
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ZEBRA amino acid sequence (natural sequence from Epstein - Barr 
       virus (EBV)) (YP_401673)

<400>  3

Met Met Asp Pro Asn Ser Thr Ser Glu Asp Val Lys Phe Thr Pro Asp 
1               5                   10                  15      


Pro Tyr Gln Val Pro Phe Val Gln Ala Phe Asp Gln Ala Thr Arg Val 
            20                  25                  30          


Tyr Gln Asp Leu Gly Gly Pro Ser Gln Ala Pro Leu Pro Cys Val Leu 
        35                  40                  45              


Trp Pro Val Leu Pro Glu Pro Leu Pro Gln Gly Gln Leu Thr Ala Tyr 
    50                  55                  60                  


His Val Ser Thr Ala Pro Thr Gly Ser Trp Phe Ser Ala Pro Gln Pro 
65                  70                  75                  80  


Ala Pro Glu Asn Ala Tyr Gln Ala Tyr Ala Ala Pro Gln Leu Phe Pro 
                85                  90                  95      


Val Ser Asp Ile Thr Gln Asn Gln Gln Thr Asn Gln Ala Gly Gly Glu 
            100                 105                 110         


Ala Pro Gln Pro Gly Asp Asn Ser Thr Val Gln Thr Ala Ala Ala Val 
        115                 120                 125             


Val Phe Ala Cys Pro Gly Ala Asn Gln Gly Gln Gln Leu Ala Asp Ile 
    130                 135                 140                 


Gly Val Pro Gln Pro Ala Pro Val Ala Ala Pro Ala Arg Arg Thr Arg 
145                 150                 155                 160 


Lys Pro Gln Gln Pro Glu Ser Leu Glu Glu Cys Asp Ser Glu Leu Glu 
                165                 170                 175     


Ile Lys Arg Tyr Lys Asn Arg Val Ala Ser Arg Lys Cys Arg Ala Lys 
            180                 185                 190         


Phe Lys Gln Leu Leu Gln His Tyr Arg Glu Val Ala Ala Ala Lys Ser 
        195                 200                 205             


Ser Glu Asn Asp Arg Leu Arg Leu Leu Leu Lys Gln Met Cys Pro Ser 
    210                 215                 220                 


Leu Asp Val Asp Ser Ile Ile Pro Arg Thr Pro Asp Val Leu His Glu 
225                 230                 235                 240 


Asp Leu Leu Asn Phe 
                245 


<210>  4
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CPP1 (Z11)

<400>  4

Lys Arg Tyr Lys Asn Arg Val Ala Ser Arg Lys Cys Arg Ala Lys Phe 
1               5                   10                  15      


Lys Gln Leu Leu Gln His Tyr Arg Glu Val Ala Ala Ala Lys Ser Ser 
            20                  25                  30          


Glu Asn Asp Arg Leu Arg Leu Leu Leu Lys Gln Met Cys 
        35                  40                  45  


<210>  5
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CPP2 (Z12)

<400>  5

Lys Arg Tyr Lys Asn Arg Val Ala Ser Arg Lys Cys Arg Ala Lys Phe 
1               5                   10                  15      


Lys Gln Leu Leu Gln His Tyr Arg Glu Val Ala Ala Ala Lys Ser Ser 
            20                  25                  30          


Glu Asn Asp Arg Leu Arg Leu Leu Leu Lys 
        35                  40          


<210>  6
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CPP3 (Z13)

<400>  6

Lys Arg Tyr Lys Asn Arg Val Ala Ser Arg Lys Ser Arg Ala Lys Phe 
1               5                   10                  15      


Lys Gln Leu Leu Gln His Tyr Arg Glu Val Ala Ala Ala Lys Ser Ser 
            20                  25                  30          


Glu Asn Asp Arg Leu Arg Leu Leu Leu Lys 
        35                  40          


<210>  7
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CPP4 (Z14)

<400>  7

Lys Arg Tyr Lys Asn Arg Val Ala Ser Arg Lys Ser Arg Ala Lys Phe 
1               5                   10                  15      


Lys Gln Leu Leu Gln His Tyr Arg Glu Val Ala Ala Ala Lys 
            20                  25                  30  


<210>  8
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CPP5 (Z15)

<400>  8

Lys Arg Tyr Lys Asn Arg Val Ala Ser Arg Lys Ser Arg Ala Lys Phe 
1               5                   10                  15      


Lys 
    


<210>  9
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CPP6 (Z16)

<400>  9

Gln His Tyr Arg Glu Val Ala Ala Ala Lys Ser Ser Glu Asn Asp 
1               5                   10                  15  


<210>  10
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CPP7 (Z17)

<400>  10

Gln Leu Leu Gln His Tyr Arg Glu Val Ala Ala Ala Lys 
1               5                   10              


<210>  11
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CPP8 (Z18)

<400>  11

Arg Glu Val Ala Ala Ala Lys Ser Ser Glu Asn Asp Arg Leu Arg Leu 
1               5                   10                  15      


Leu Leu Lys 
            


<210>  12
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CPP9 (Z19)

<400>  12

Lys Arg Tyr Lys Asn Arg Val Ala 
1               5               


<210>  13
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CPP10 (Z20)

<400>  13

Val Ala Ser Arg Lys Ser Arg Ala Lys Phe Lys 
1               5                   10      


<210>  14
<211>  85
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MAD5 cargo

<400>  14

Glu Ser Leu Lys Ile Ser Gln Ala Val His Ala Ala His Ala Glu Ile 
1               5                   10                  15      


Asn Glu Ala Gly Arg Glu Val Val Gly Val Gly Ala Leu Lys Val Pro 
            20                  25                  30          


Arg Asn Gln Asp Trp Leu Gly Val Pro Arg Phe Ala Lys Phe Ala Ser 
        35                  40                  45              


Phe Glu Ala Gln Gly Ala Leu Ala Asn Ile Ala Val Asp Lys Ala Asn 
    50                  55                  60                  


Leu Asp Val Glu Gln Leu Glu Ser Ile Ile Asn Phe Glu Lys Leu Thr 
65                  70                  75                  80  


Glu Trp Thr Gly Ser 
                85  


<210>  15
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TLR2 peptide agonist Anaxa

<400>  15

Ser Thr Val His Glu Ile Leu Cys Lys Leu Ser Leu Glu Gly Asp His 
1               5                   10                  15      


Ser Thr Pro Pro Ser Ala Tyr Gly Ser Val Lys Pro Tyr Thr Asn Phe 
            20                  25                  30          


Asp Ala Glu 
        35  


<210>  16
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  enterokinase target site

<400>  16

Asp Asp Asp Lys 
1               


<210>  17
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  factor Xa target site

<400>  17

Ile Glu Asp Gly Arg 
1               5   


<210>  18
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  thrombin target site

<400>  18

Leu Val Pro Arg Gly Ser 
1               5       


<210>  19
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease TEV target site

<400>  19

Glu Asn Leu Tyr Phe Gln Gly 
1               5           


<210>  20
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PreScission protease target site

<400>  20

Leu Glu Val Leu Phe Gln Gly Pro 
1               5               


<210>  21
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  furin target site


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X may be any amino acid

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X is R or K

<400>  21

Arg Xaa Xaa Arg 
1               


<210>  22
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptidic linker

<400>  22

Gly Gly Gly Gly Gly 
1               5   


<210>  23
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptidic linker

<400>  23

Gly Gly Gly Gly 
1               


<210>  24
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptidic linker

<400>  24

Glu Gln Leu Glu 
1               


<210>  25
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptidic linker

<400>  25

Thr Glu Trp Thr 
1               


<210>  26
<211>  224
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EDAZ13Mad5

<400>  26

Met His His His His His His Asn Ile Asp Arg Pro Lys Gly Leu Ala 
1               5                   10                  15      


Phe Thr Asp Val Asp Val Asp Ser Ile Lys Ile Ala Trp Glu Ser Pro 
            20                  25                  30          


Gln Gly Gln Val Ser Arg Tyr Arg Val Thr Tyr Ser Ser Pro Glu Asp 
        35                  40                  45              


Gly Ile Arg Glu Leu Phe Pro Ala Pro Asp Gly Glu Asp Asp Thr Ala 
    50                  55                  60                  


Glu Leu Gln Gly Leu Arg Pro Gly Ser Glu Tyr Thr Val Ser Val Val 
65                  70                  75                  80  


Ala Leu His Asp Asp Met Glu Ser Gln Pro Leu Ile Gly Ile Gln Ser 
                85                  90                  95      


Thr Lys Arg Tyr Lys Asn Arg Val Ala Ser Arg Lys Ser Arg Ala Lys 
            100                 105                 110         


Phe Lys Gln Leu Leu Gln His Tyr Arg Glu Val Ala Ala Ala Lys Ser 
        115                 120                 125             


Ser Glu Asn Asp Arg Leu Arg Leu Leu Leu Lys Glu Ser Leu Lys Ile 
    130                 135                 140                 


Ser Gln Ala Val His Ala Ala His Ala Glu Ile Asn Glu Ala Gly Arg 
145                 150                 155                 160 


Glu Val Val Gly Val Gly Ala Leu Lys Val Pro Arg Asn Gln Asp Trp 
                165                 170                 175     


Leu Gly Val Pro Arg Phe Ala Lys Phe Ala Ser Phe Glu Ala Gln Gly 
            180                 185                 190         


Ala Leu Ala Asn Ile Ala Val Asp Lys Ala Asn Leu Asp Val Glu Gln 
        195                 200                 205             


Leu Glu Ser Ile Ile Asn Phe Glu Lys Leu Thr Glu Trp Thr Gly Ser 
    210                 215                 220                 


<210>  27
<211>  169
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AnaxaZ13Mad5

<400>  27

Met His His His His His His Ser Thr Val His Glu Ile Leu Cys Lys 
1               5                   10                  15      


Leu Ser Leu Glu Gly Asp His Ser Thr Pro Pro Ser Ala Tyr Gly Ser 
            20                  25                  30          


Val Lys Pro Tyr Thr Asn Phe Asp Ala Glu Lys Arg Tyr Lys Asn Arg 
        35                  40                  45              


Val Ala Ser Arg Lys Ser Arg Ala Lys Phe Lys Gln Leu Leu Gln His 
    50                  55                  60                  


Tyr Arg Glu Val Ala Ala Ala Lys Ser Ser Glu Asn Asp Arg Leu Arg 
65                  70                  75                  80  


Leu Leu Leu Lys Glu Ser Leu Lys Ile Ser Gln Ala Val His Ala Ala 
                85                  90                  95      


His Ala Glu Ile Asn Glu Ala Gly Arg Glu Val Val Gly Val Gly Ala 
            100                 105                 110         


Leu Lys Val Pro Arg Asn Gln Asp Trp Leu Gly Val Pro Arg Phe Ala 
        115                 120                 125             


Lys Phe Ala Ser Phe Glu Ala Gln Gly Ala Leu Ala Asn Ile Ala Val 
    130                 135                 140                 


Asp Lys Ala Asn Leu Asp Val Glu Gln Leu Glu Ser Ile Ile Asn Phe 
145                 150                 155                 160 


Glu Lys Leu Thr Glu Trp Thr Gly Ser 
                165                 


<210>  28
<211>  169
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Z13Mad5Anaxa

<400>  28

Met His His His His His His Lys Arg Tyr Lys Asn Arg Val Ala Ser 
1               5                   10                  15      


Arg Lys Ser Arg Ala Lys Phe Lys Gln Leu Leu Gln His Tyr Arg Glu 
            20                  25                  30          


Val Ala Ala Ala Lys Ser Ser Glu Asn Asp Arg Leu Arg Leu Leu Leu 
        35                  40                  45              


Lys Glu Ser Leu Lys Ile Ser Gln Ala Val His Ala Ala His Ala Glu 
    50                  55                  60                  


Ile Asn Glu Ala Gly Arg Glu Val Val Gly Val Gly Ala Leu Lys Val 
65                  70                  75                  80  


Pro Arg Asn Gln Asp Trp Leu Gly Val Pro Arg Phe Ala Lys Phe Ala 
                85                  90                  95      


Ser Phe Glu Ala Gln Gly Ala Leu Ala Asn Ile Ala Val Asp Lys Ala 
            100                 105                 110         


Asn Leu Asp Val Glu Gln Leu Glu Ser Ile Ile Asn Phe Glu Lys Leu 
        115                 120                 125             


Thr Glu Trp Thr Gly Ser Ser Thr Val His Glu Ile Leu Cys Lys Leu 
    130                 135                 140                 


Ser Leu Glu Gly Asp His Ser Thr Pro Pro Ser Ala Tyr Gly Ser Val 
145                 150                 155                 160 


Lys Pro Tyr Thr Asn Phe Asp Ala Glu 
                165                 


<210>  29
<211>  157
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Z14Mad5Anaxa

<400>  29

Met His His His His His His Lys Arg Tyr Lys Asn Arg Val Ala Ser 
1               5                   10                  15      


Arg Lys Ser Arg Ala Lys Phe Lys Gln Leu Leu Gln His Tyr Arg Glu 
            20                  25                  30          


Val Ala Ala Ala Lys Glu Ser Leu Lys Ile Ser Gln Ala Val His Ala 
        35                  40                  45              


Ala His Ala Glu Ile Asn Glu Ala Gly Arg Glu Val Val Gly Val Gly 
    50                  55                  60                  


Ala Leu Lys Val Pro Arg Asn Gln Asp Trp Leu Gly Val Pro Arg Phe 
65                  70                  75                  80  


Ala Lys Phe Ala Ser Phe Glu Ala Gln Gly Ala Leu Ala Asn Ile Ala 
                85                  90                  95      


Val Asp Lys Ala Asn Leu Asp Val Glu Gln Leu Glu Ser Ile Ile Asn 
            100                 105                 110         


Phe Glu Lys Leu Thr Glu Trp Thr Gly Ser Ser Thr Val His Glu Ile 
        115                 120                 125             


Leu Cys Lys Leu Ser Leu Glu Gly Asp His Ser Thr Pro Pro Ser Ala 
    130                 135                 140                 


Tyr Gly Ser Val Lys Pro Tyr Thr Asn Phe Asp Ala Glu 
145                 150                 155         


<210>  30
<211>  146
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Z18Mad5Anaxa

<400>  30

Met His His His His His His Arg Glu Val Ala Ala Ala Lys Ser Ser 
1               5                   10                  15      


Glu Asn Asp Arg Leu Arg Leu Leu Leu Lys Glu Ser Leu Lys Ile Ser 
            20                  25                  30          


Gln Ala Val His Ala Ala His Ala Glu Ile Asn Glu Ala Gly Arg Glu 
        35                  40                  45              


Val Val Gly Val Gly Ala Leu Lys Val Pro Arg Asn Gln Asp Trp Leu 
    50                  55                  60                  


Gly Val Pro Arg Phe Ala Lys Phe Ala Ser Phe Glu Ala Gln Gly Ala 
65                  70                  75                  80  


Leu Ala Asn Ile Ala Val Asp Lys Ala Asn Leu Asp Val Glu Gln Leu 
                85                  90                  95      


Glu Ser Ile Ile Asn Phe Glu Lys Leu Thr Glu Trp Thr Gly Ser Ser 
            100                 105                 110         


Thr Val His Glu Ile Leu Cys Lys Leu Ser Leu Glu Gly Asp His Ser 
        115                 120                 125             


Thr Pro Pro Ser Ala Tyr Gly Ser Val Lys Pro Tyr Thr Asn Phe Asp 
    130                 135                 140                 


Ala Glu 
145     


<210>  31
<211>  212
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EDAZ14Mad5

<400>  31

Met His His His His His His Asn Ile Asp Arg Pro Lys Gly Leu Ala 
1               5                   10                  15      


Phe Thr Asp Val Asp Val Asp Ser Ile Lys Ile Ala Trp Glu Ser Pro 
            20                  25                  30          


Gln Gly Gln Val Ser Arg Tyr Arg Val Thr Tyr Ser Ser Pro Glu Asp 
        35                  40                  45              


Gly Ile Arg Glu Leu Phe Pro Ala Pro Asp Gly Glu Asp Asp Thr Ala 
    50                  55                  60                  


Glu Leu Gln Gly Leu Arg Pro Gly Ser Glu Tyr Thr Val Ser Val Val 
65                  70                  75                  80  


Ala Leu His Asp Asp Met Glu Ser Gln Pro Leu Ile Gly Ile Gln Ser 
                85                  90                  95      


Thr Lys Arg Tyr Lys Asn Arg Val Ala Ser Arg Lys Ser Arg Ala Lys 
            100                 105                 110         


Phe Lys Gln Leu Leu Gln His Tyr Arg Glu Val Ala Ala Ala Lys Glu 
        115                 120                 125             


Ser Leu Lys Ile Ser Gln Ala Val His Ala Ala His Ala Glu Ile Asn 
    130                 135                 140                 


Glu Ala Gly Arg Glu Val Val Gly Val Gly Ala Leu Lys Val Pro Arg 
145                 150                 155                 160 


Asn Gln Asp Trp Leu Gly Val Pro Arg Phe Ala Lys Phe Ala Ser Phe 
                165                 170                 175     


Glu Ala Gln Gly Ala Leu Ala Asn Ile Ala Val Asp Lys Ala Asn Leu 
            180                 185                 190         


Asp Val Glu Gln Leu Glu Ser Ile Ile Asn Phe Glu Lys Leu Thr Glu 
        195                 200                 205             


Trp Thr Gly Ser 
    210         


<210>  32
<211>  201
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EDAZ18Mad5

<400>  32

Met His His His His His His Asn Ile Asp Arg Pro Lys Gly Leu Ala 
1               5                   10                  15      


Phe Thr Asp Val Asp Val Asp Ser Ile Lys Ile Ala Trp Glu Ser Pro 
            20                  25                  30          


Gln Gly Gln Val Ser Arg Tyr Arg Val Thr Tyr Ser Ser Pro Glu Asp 
        35                  40                  45              


Gly Ile Arg Glu Leu Phe Pro Ala Pro Asp Gly Glu Asp Asp Thr Ala 
    50                  55                  60                  


Glu Leu Gln Gly Leu Arg Pro Gly Ser Glu Tyr Thr Val Ser Val Val 
65                  70                  75                  80  


Ala Leu His Asp Asp Met Glu Ser Gln Pro Leu Ile Gly Ile Gln Ser 
                85                  90                  95      


Thr Arg Glu Val Ala Ala Ala Lys Ser Ser Glu Asn Asp Arg Leu Arg 
            100                 105                 110         


Leu Leu Leu Lys Glu Ser Leu Lys Ile Ser Gln Ala Val His Ala Ala 
        115                 120                 125             


His Ala Glu Ile Asn Glu Ala Gly Arg Glu Val Val Gly Val Gly Ala 
    130                 135                 140                 


Leu Lys Val Pro Arg Asn Gln Asp Trp Leu Gly Val Pro Arg Phe Ala 
145                 150                 155                 160 


Lys Phe Ala Ser Phe Glu Ala Gln Gly Ala Leu Ala Asn Ile Ala Val 
                165                 170                 175     


Asp Lys Ala Asn Leu Asp Val Glu Gln Leu Glu Ser Ile Ile Asn Phe 
            180                 185                 190         


Glu Lys Leu Thr Glu Trp Thr Gly Ser 
        195                 200     


<210>  33
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Z13Mad8Anaxa

<400>  33

Lys Arg Tyr Lys Asn Arg Val Ala Ser Arg Lys Ser Arg Ala Lys Phe 
1               5                   10                  15      


Lys Gln Leu Leu Gln His Tyr Arg Glu Val Ala Ala Ala Lys Ser Ser 
            20                  25                  30          


Glu Asn Asp Arg Leu Arg Leu Leu Leu Lys Val Thr Tyr His Ser Pro 
        35                  40                  45              


Ser Tyr Val Tyr His Gln Phe Glu Arg Arg Ala Ile Leu Asn Arg Leu 
    50                  55                  60                  


Val Gln Phe Ile Lys Asp Arg Ile Ser Val Val Gln Ala Leu Val Leu 
65                  70                  75                  80  


Thr Ser Thr Val His Glu Ile Leu Cys Lys Leu Ser Leu Glu Gly Asp 
                85                  90                  95      


His Ser Thr Pro Pro Ser Ala Tyr Gly Ser Val Lys Pro Tyr Thr Asn 
            100                 105                 110         


Phe Asp Ala Glu 
        115     


<210>  34
<211>  182
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EDAMad5

<400>  34

Met His His His His His His Asn Ile Asp Arg Pro Lys Gly Leu Ala 
1               5                   10                  15      


Phe Thr Asp Val Asp Val Asp Ser Ile Lys Ile Ala Trp Glu Ser Pro 
            20                  25                  30          


Gln Gly Gln Val Ser Arg Tyr Arg Val Thr Tyr Ser Ser Pro Glu Asp 
        35                  40                  45              


Gly Ile Arg Glu Leu Phe Pro Ala Pro Asp Gly Glu Asp Asp Thr Ala 
    50                  55                  60                  


Glu Leu Gln Gly Leu Arg Pro Gly Ser Glu Tyr Thr Val Ser Val Val 
65                  70                  75                  80  


Ala Leu His Asp Asp Met Glu Ser Gln Pro Leu Ile Gly Ile Gln Ser 
                85                  90                  95      


Thr Glu Ser Leu Lys Ile Ser Gln Ala Val His Ala Ala His Ala Glu 
            100                 105                 110         


Ile Asn Glu Ala Gly Arg Glu Val Val Gly Val Gly Ala Leu Lys Val 
        115                 120                 125             


Pro Arg Asn Gln Asp Trp Leu Gly Val Pro Arg Phe Ala Lys Phe Ala 
    130                 135                 140                 


Ser Phe Glu Ala Gln Gly Ala Leu Ala Asn Ile Ala Val Asp Lys Ala 
145                 150                 155                 160 


Asn Leu Asp Val Glu Gln Leu Glu Ser Ile Ile Asn Phe Glu Lys Leu 
                165                 170                 175     


Thr Glu Trp Thr Gly Ser 
            180         


<210>  35
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SIINFEKL OVACD8 peptide

<400>  35

Ser Ile Ile Asn Phe Glu Lys Leu 
1               5               


<210>  36
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mad8

<400>  36

Val Thr Tyr His Ser Pro Ser Tyr Ala Tyr His Gln Phe Glu Arg Arg 
1               5                   10                  15      


Ala Ile Leu Asn Arg Leu Val Gln Phe Ile Lys Asp Arg Ile 
            20                  25                  30  


<210>  37
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mad11

<400>  37

Asn Tyr Arg Ile Ala Thr Phe Lys Asn Trp Pro Phe Leu Glu Asp Cys 
1               5                   10                  15      


Ala Met Glu Glu Leu Thr Val Ser Glu Phe Leu Lys Leu Asp Arg Gln 
            20                  25                  30          


Arg 
    


<210>  38
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mad9

<400>  38

His Leu Glu Leu Ala Ser Met Thr Asn Met Glu Leu Met Ser Ser Ile 
1               5                   10                  15      


Val 
    


<210>  39
<211>  50
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mad12

<400>  39

Leu Phe Arg Ala Ala Gln Leu Ala Asn Asp Val Val Leu Gln Ile Met 
1               5                   10                  15      


Glu His Leu Glu Leu Ala Ser Met Thr Asn Met Glu Leu Met Ser Ser 
            20                  25                  30          


Ile Val Val Ile Ser Ala Ser Ile Ile Val Phe Asn Leu Leu Glu Leu 
        35                  40                  45              


Glu Gly 
    50  


<210>  40
<211>  90
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EDA

<400>  40

Asn Ile Asp Arg Pro Lys Gly Leu Ala Phe Thr Asp Val Asp Val Asp 
1               5                   10                  15      


Ser Ile Lys Ile Ala Trp Glu Ser Pro Gln Gly Gln Val Ser Arg Tyr 
            20                  25                  30          


Arg Val Thr Tyr Ser Ser Pro Glu Asp Gly Ile Arg Glu Leu Phe Pro 
        35                  40                  45              


Ala Pro Asp Gly Glu Asp Asp Thr Ala Glu Leu Gln Gly Leu Arg Pro 
    50                  55                  60                  


Gly Ser Glu Tyr Thr Val Ser Val Val Ala Leu His Asp Asp Met Glu 
65                  70                  75                  80  


Ser Gln Pro Leu Ile Gly Ile Gln Ser Thr 
                85                  90  


<210>  41
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Z13Mad8Anaxa

<400>  41

Lys Arg Tyr Lys Asn Arg Val Ala Ser Arg Lys Ser Arg Ala Lys Phe 
1               5                   10                  15      


Lys Gln Leu Leu Gln His Tyr Arg Glu Val Ala Ala Ala Lys Ser Ser 
            20                  25                  30          


Glu Asn Asp Arg Leu Arg Leu Leu Leu Lys Val Thr Tyr His Ser Pro 
        35                  40                  45              


Ser Tyr Ala Tyr His Gln Phe Glu Arg Arg Ala Ile Leu Asn Arg Leu 
    50                  55                  60                  


Val Gln Phe Ile Lys Asp Arg Ile Ser Val Val Gln Ala Leu Val Leu 
65                  70                  75                  80  


Thr Ser Thr Val His Glu Ile Leu Cys Lys Leu Ser Leu Glu Gly Asp 
                85                  90                  95      


His Ser Thr Pro Pro Ser Ala Tyr Gly Ser Val Lys Pro Tyr Thr Asn 
            100                 105                 110         


Phe Asp Ala Glu 
        115     


<210>  42
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Z13Mad11Anaxa

<400>  42

Lys Arg Tyr Lys Asn Arg Val Ala Ser Arg Lys Ser Arg Ala Lys Phe 
1               5                   10                  15      


Lys Gln Leu Leu Gln His Tyr Arg Glu Val Ala Ala Ala Lys Ser Ser 
            20                  25                  30          


Glu Asn Asp Arg Leu Arg Leu Leu Leu Lys Asn Tyr Arg Ile Ala Thr 
        35                  40                  45              


Phe Lys Asn Trp Pro Phe Leu Glu Asp Cys Ala Met Glu Glu Leu Thr 
    50                  55                  60                  


Val Ser Glu Phe Leu Lys Leu Asp Arg Gln Arg Ser Thr Val His Glu 
65                  70                  75                  80  


Ile Leu Cys Lys Leu Ser Leu Glu Gly Asp His Ser Thr Pro Pro Ser 
                85                  90                  95      


Ala Tyr Gly Ser Val Lys Pro Tyr Thr Asn Phe Asp Ala Glu 
            100                 105                 110 


<210>  43
<211>  94
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Z13Mad9Anaxa

<400>  43

Lys Arg Tyr Lys Asn Arg Val Ala Ser Arg Lys Ser Arg Ala Lys Phe 
1               5                   10                  15      


Lys Gln Leu Leu Gln His Tyr Arg Glu Val Ala Ala Ala Lys Ser Ser 
            20                  25                  30          


Glu Asn Asp Arg Leu Arg Leu Leu Leu Lys His Leu Glu Leu Ala Ser 
        35                  40                  45              


Met Thr Asn Met Glu Leu Met Ser Ser Ile Val Ser Thr Val His Glu 
    50                  55                  60                  


Ile Leu Cys Lys Leu Ser Leu Glu Gly Asp His Ser Thr Pro Pro Ser 
65                  70                  75                  80  


Ala Tyr Gly Ser Val Lys Pro Tyr Thr Asn Phe Asp Ala Glu 
                85                  90                  


<210>  44
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TatFMad5Anaxa

<400>  44

Arg Lys Lys Arg Arg Gln Arg Arg Arg Arg Val Lys Arg Ile Ser Gln 
1               5                   10                  15      


Ala Val His Ala Ala His Ala Glu Ile Asn Glu Ala Gly Arg Arg Val 
            20                  25                  30          


Lys Arg Lys Val Pro Arg Asn Gln Asp Trp Leu Arg Val Lys Arg Ala 
        35                  40                  45              


Ser Phe Glu Ala Gln Gly Ala Leu Ala Asn Ile Ala Val Asp Lys Ala 
    50                  55                  60                  


Arg Val Lys Arg Ser Ile Ile Asn Phe Glu Lys Leu Arg Val Lys Arg 
65                  70                  75                  80  


Ser Thr Val His Glu Ile Leu Cys Lys Leu Ser Leu Glu Gly Asp His 
                85                  90                  95      


Ser Thr Pro Pro Ser Ala Tyr Gly Ser Val Lys Pro Tyr Thr Asn Phe 
            100                 105                 110         


Asp Ala Glu 
        115 


<210>  45
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Z13Mad12Anaxa

<400>  45

Lys Arg Tyr Lys Asn Arg Val Ala Ser Arg Lys Ser Arg Ala Lys Phe 
1               5                   10                  15      


Lys Gln Leu Leu Gln His Tyr Arg Glu Val Ala Ala Ala Lys Ser Ser 
            20                  25                  30          


Glu Asn Asp Arg Leu Arg Leu Leu Leu Lys Leu Phe Arg Ala Ala Gln 
        35                  40                  45              


Leu Ala Asn Asp Val Val Leu Gln Ile Met Glu His Leu Glu Leu Ala 
    50                  55                  60                  


Ser Met Thr Asn Met Glu Leu Met Ser Ser Ile Val Val Ile Ser Ala 
65                  70                  75                  80  


Ser Ile Ile Val Phe Asn Leu Leu Glu Leu Glu Gly Ser Thr Val His 
                85                  90                  95      


Glu Ile Leu Cys Lys Leu Ser Leu Glu Gly Asp His Ser Thr Pro Pro 
            100                 105                 110         


Ser Ala Tyr Gly Ser Val Lys Pro Tyr Thr Asn Phe Asp Ala Glu 
        115                 120                 125         


<210>  46
<211>  134
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Z13Mad5

<400>  46

Met His His His His His His Lys Arg Tyr Lys Asn Arg Val Ala Ser 
1               5                   10                  15      


Arg Lys Ser Arg Ala Lys Phe Lys Gln Leu Leu Gln His Tyr Arg Glu 
            20                  25                  30          


Val Ala Ala Ala Lys Ser Ser Glu Asn Asp Arg Leu Arg Leu Leu Leu 
        35                  40                  45              


Lys Glu Ser Leu Lys Ile Ser Gln Ala Val His Ala Ala His Ala Glu 
    50                  55                  60                  


Ile Asn Glu Ala Gly Arg Glu Val Val Gly Val Gly Ala Leu Lys Val 
65                  70                  75                  80  


Pro Arg Asn Gln Asp Trp Leu Gly Val Pro Arg Phe Ala Lys Phe Ala 
                85                  90                  95      


Ser Phe Glu Ala Gln Gly Ala Leu Ala Asn Ile Ala Val Asp Lys Ala 
            100                 105                 110         


Asn Leu Asp Val Glu Gln Leu Glu Ser Ile Ile Asn Phe Glu Lys Leu 
        115                 120                 125             


Thr Glu Trp Thr Gly Ser 
    130                 


<210>  47
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TLR peptide agonist: "Anaxa" sequence variant

<400>  47

Ser Thr Val His Glu Ile Leu Ser Lys Leu Ser Leu Glu Gly Asp His 
1               5                   10                  15      


Ser Thr Pro Pro Ser Ala Tyr Gly Ser Val Lys Pro Tyr Thr Asn Phe 
            20                  25                  30          


Asp Ala Glu 
        35  


