                         SEQUENCE LISTING

<110>  Cynata Therapeutics Limited
 
<120>  Colony Forming Medium and Use Thereof

<130>  P100952.PCT

<150>  AU 2016900983
<151>  2016-03-16

<150>  AU 2016904039
<151>  2016-10-05

<150>  AU 2017900318
<151>  2017-02-02

<160>  8     

<170>  PatentIn version 3.5

<210>  1
<211>  116
<212>  PRT
<213>  Homo sapiens

<400>  1

Gly Leu Glu Cys Asp Gly Lys Val Asn Ile Cys Cys Lys Lys Gln Phe 
1               5                   10                  15      


Phe Val Ser Phe Lys Asp Ile Gly Trp Asn Asp Trp Ile Ile Ala Pro 
            20                  25                  30          


Ser Gly Tyr His Ala Asn Tyr Cys Glu Gly Glu Cys Pro Ser His Ile 
        35                  40                  45              


Ala Gly Thr Ser Gly Ser Ser Leu Ser Phe His Ser Thr Val Ile Asn 
    50                  55                  60                  


His Tyr Arg Met Arg Gly His Ser Pro Phe Ala Asn Leu Lys Ser Cys 
65                  70                  75                  80  


Cys Val Pro Thr Lys Leu Arg Pro Met Ser Met Leu Tyr Tyr Asp Asp 
                85                  90                  95      


Gly Gln Asn Ile Ile Lys Lys Asp Ile Gln Asn Met Ile Val Glu Glu 
            100                 105                 110         


Cys Gly Cys Ser 
        115     


<210>  2
<211>  106
<212>  PRT
<213>  Homo sapiens

<400>  2

Lys Lys Asn Lys Asn Cys Arg Arg His Ser Leu Tyr Val Asp Phe Ser 
1               5                   10                  15      


Asp Val Gly Trp Asn Asp Trp Ile Val Ala Pro Pro Gly Tyr Gln Ala 
            20                  25                  30          


Phe Tyr Cys His Gly Asp Cys Pro Phe Pro Leu Ala Asp His Leu Asn 
        35                  40                  45              


Ser Thr Asn His Ala Ile Val Gln Thr Leu Val Asn Ser Val Asn Ser 
    50                  55                  60                  


Ser Ile Pro Lys Ala Cys Cys Val Pro Thr Glu Leu Ser Ala Ile Ser 
65                  70                  75                  80  


Met Leu Tyr Leu Asp Glu Tyr Asp Lys Val Val Leu Lys Asn Tyr Gln 
                85                  90                  95      


Glu Met Val Val Glu Gly Cys Gly Cys Arg 
            100                 105     


<210>  3
<211>  1057
<212>  PRT
<213>  Homo sapiens

<400>  3

Gln Leu Ser Tyr Gly Tyr Asp Glu Lys Ser Thr Gly Gly Ile Ser Val 
1               5                   10                  15      


Pro Gly Pro Met Gly Pro Ser Gly Pro Arg Gly Leu Pro Gly Pro Pro 
            20                  25                  30          


Gly Ala Pro Gly Pro Gln Gly Phe Gln Gly Pro Pro Gly Glu Pro Gly 
        35                  40                  45              


Glu Pro Gly Ala Ser Gly Pro Met Gly Pro Arg Gly Pro Pro Gly Pro 
    50                  55                  60                  


Pro Gly Lys Asn Gly Asp Asp Gly Glu Ala Gly Lys Pro Gly Arg Pro 
65                  70                  75                  80  


Gly Glu Arg Gly Pro Pro Gly Pro Gln Gly Ala Arg Gly Leu Pro Gly 
                85                  90                  95      


Thr Ala Gly Leu Pro Gly Met Lys Gly His Arg Gly Phe Ser Gly Leu 
            100                 105                 110         


Asp Gly Ala Lys Gly Asp Ala Gly Pro Ala Gly Pro Lys Gly Glu Pro 
        115                 120                 125             


Gly Ser Pro Gly Glu Asn Gly Ala Pro Gly Gln Met Gly Pro Arg Gly 
    130                 135                 140                 


Leu Pro Gly Glu Arg Gly Arg Pro Gly Ala Pro Gly Pro Ala Gly Ala 
145                 150                 155                 160 


Arg Gly Asn Asp Gly Ala Thr Gly Ala Ala Gly Pro Pro Gly Pro Thr 
                165                 170                 175     


Gly Pro Ala Gly Pro Pro Gly Phe Pro Gly Ala Val Gly Ala Lys Gly 
            180                 185                 190         


Glu Ala Gly Pro Gln Gly Pro Arg Gly Ser Glu Gly Pro Gln Gly Val 
        195                 200                 205             


Arg Gly Glu Pro Gly Pro Pro Gly Pro Ala Gly Ala Ala Gly Pro Ala 
    210                 215                 220                 


Gly Asn Pro Gly Ala Asp Gly Gln Pro Gly Ala Lys Gly Ala Asn Gly 
225                 230                 235                 240 


Ala Pro Gly Ile Ala Gly Ala Pro Gly Phe Pro Gly Ala Arg Gly Pro 
                245                 250                 255     


Ser Gly Pro Gln Gly Pro Gly Gly Pro Pro Gly Pro Lys Gly Asn Ser 
            260                 265                 270         


Gly Glu Pro Gly Ala Pro Gly Ser Lys Gly Asp Thr Gly Ala Lys Gly 
        275                 280                 285             


Glu Pro Gly Pro Val Gly Val Gln Gly Pro Pro Gly Pro Ala Gly Glu 
    290                 295                 300                 


Glu Gly Lys Arg Gly Ala Arg Gly Glu Pro Gly Pro Thr Gly Leu Pro 
305                 310                 315                 320 


Gly Pro Pro Gly Glu Arg Gly Gly Pro Gly Ser Arg Gly Phe Pro Gly 
                325                 330                 335     


Ala Asp Gly Val Ala Gly Pro Lys Gly Pro Ala Gly Glu Arg Gly Ser 
            340                 345                 350         


Pro Gly Pro Ala Gly Pro Lys Gly Ser Pro Gly Glu Ala Gly Arg Pro 
        355                 360                 365             


Gly Glu Ala Gly Leu Pro Gly Ala Lys Gly Leu Thr Gly Ser Pro Gly 
    370                 375                 380                 


Ser Pro Gly Pro Asp Gly Lys Thr Gly Pro Pro Gly Pro Ala Gly Gln 
385                 390                 395                 400 


Asp Gly Arg Pro Gly Pro Pro Gly Pro Pro Gly Ala Arg Gly Gln Ala 
                405                 410                 415     


Gly Val Met Gly Phe Pro Gly Pro Lys Gly Ala Ala Gly Glu Pro Gly 
            420                 425                 430         


Lys Ala Gly Glu Arg Gly Val Pro Gly Pro Pro Gly Ala Val Gly Pro 
        435                 440                 445             


Ala Gly Lys Asp Gly Glu Ala Gly Ala Gln Gly Pro Pro Gly Pro Ala 
    450                 455                 460                 


Gly Pro Ala Gly Glu Arg Gly Glu Gln Gly Pro Ala Gly Ser Pro Gly 
465                 470                 475                 480 


Phe Gln Gly Leu Pro Gly Pro Ala Gly Pro Pro Gly Glu Ala Gly Lys 
                485                 490                 495     


Pro Gly Glu Gln Gly Val Pro Gly Asp Leu Gly Ala Pro Gly Pro Ser 
            500                 505                 510         


Gly Ala Arg Gly Glu Arg Gly Phe Pro Gly Glu Arg Gly Val Gln Gly 
        515                 520                 525             


Pro Pro Gly Pro Ala Gly Pro Arg Gly Ala Asn Gly Ala Pro Gly Asn 
    530                 535                 540                 


Asp Gly Ala Lys Gly Asp Ala Gly Ala Pro Gly Ala Pro Gly Ser Gln 
545                 550                 555                 560 


Gly Ala Pro Gly Leu Gln Gly Met Pro Gly Glu Arg Gly Ala Ala Gly 
                565                 570                 575     


Leu Pro Gly Pro Lys Gly Asp Arg Gly Asp Ala Gly Pro Lys Gly Ala 
            580                 585                 590         


Asp Gly Ser Pro Gly Lys Asp Gly Val Arg Gly Leu Thr Gly Pro Ile 
        595                 600                 605             


Gly Pro Pro Gly Pro Ala Gly Ala Pro Gly Asp Lys Gly Glu Ser Gly 
    610                 615                 620                 


Pro Ser Gly Pro Ala Gly Pro Thr Gly Ala Arg Gly Ala Pro Gly Asp 
625                 630                 635                 640 


Arg Gly Glu Pro Gly Pro Pro Gly Pro Ala Gly Phe Ala Gly Pro Pro 
                645                 650                 655     


Gly Ala Asp Gly Gln Pro Gly Ala Lys Gly Glu Pro Gly Asp Ala Gly 
            660                 665                 670         


Ala Lys Gly Asp Ala Gly Pro Pro Gly Pro Ala Gly Pro Ala Gly Pro 
        675                 680                 685             


Pro Gly Pro Ile Gly Asn Val Gly Ala Pro Gly Ala Lys Gly Ala Arg 
    690                 695                 700                 


Gly Ser Ala Gly Pro Pro Gly Ala Thr Gly Phe Pro Gly Ala Ala Gly 
705                 710                 715                 720 


Arg Val Gly Pro Pro Gly Pro Ser Gly Asn Ala Gly Pro Pro Gly Pro 
                725                 730                 735     


Pro Gly Pro Ala Gly Lys Glu Gly Gly Lys Gly Pro Arg Gly Glu Thr 
            740                 745                 750         


Gly Pro Ala Gly Arg Pro Gly Glu Val Gly Pro Pro Gly Pro Pro Gly 
        755                 760                 765             


Pro Ala Gly Glu Lys Gly Ser Pro Gly Ala Asp Gly Pro Ala Gly Ala 
    770                 775                 780                 


Pro Gly Thr Pro Gly Pro Gln Gly Ile Ala Gly Gln Arg Gly Val Val 
785                 790                 795                 800 


Gly Leu Pro Gly Gln Arg Gly Glu Arg Gly Phe Pro Gly Leu Pro Gly 
                805                 810                 815     


Pro Ser Gly Glu Pro Gly Lys Gln Gly Pro Ser Gly Ala Ser Gly Glu 
            820                 825                 830         


Arg Gly Pro Pro Gly Pro Met Gly Pro Pro Gly Leu Ala Gly Pro Pro 
        835                 840                 845             


Gly Glu Ser Gly Arg Glu Gly Ala Pro Gly Ala Glu Gly Ser Pro Gly 
    850                 855                 860                 


Arg Asp Gly Ser Pro Gly Ala Lys Gly Asp Arg Gly Glu Thr Gly Pro 
865                 870                 875                 880 


Ala Gly Pro Pro Gly Ala Pro Gly Ala Pro Gly Ala Pro Gly Pro Val 
                885                 890                 895     


Gly Pro Ala Gly Lys Ser Gly Asp Arg Gly Glu Thr Gly Pro Ala Gly 
            900                 905                 910         


Pro Ala Gly Pro Val Gly Pro Val Gly Ala Arg Gly Pro Ala Gly Pro 
        915                 920                 925             


Gln Gly Pro Arg Gly Asp Lys Gly Glu Thr Gly Glu Gln Gly Asp Arg 
    930                 935                 940                 


Gly Ile Lys Gly His Arg Gly Phe Ser Gly Leu Gln Gly Pro Pro Gly 
945                 950                 955                 960 


Pro Pro Gly Ser Pro Gly Glu Gln Gly Pro Ser Gly Ala Ser Gly Pro 
                965                 970                 975     


Ala Gly Pro Arg Gly Pro Pro Gly Ser Ala Gly Ala Pro Gly Lys Asp 
            980                 985                 990         


Gly Leu Asn Gly Leu Pro Gly Pro  Ile Gly Pro Pro Gly  Pro Arg Gly 
        995                 1000                 1005             


Arg Thr  Gly Asp Ala Gly Pro  Val Gly Pro Pro Gly  Pro Pro Gly 
    1010                 1015                 1020             


Pro Pro  Gly Pro Pro Gly Pro  Pro Ser Ala Gly Phe  Asp Phe Ser 
    1025                 1030                 1035             


Phe Leu  Pro Gln Pro Pro Gln  Glu Lys Ala His Asp  Gly Gly Arg 
    1040                 1045                 1050             


Tyr Tyr  Arg Ala 
    1055         


<210>  4
<211>  1497
<212>  PRT
<213>  Homo sapiens

<400>  4

Gly Glu Arg Gly Phe Pro Gly Ile Pro Gly Thr Pro Gly Pro Pro Gly 
1               5                   10                  15      


Leu Pro Gly Leu Gln Gly Pro Val Gly Pro Pro Gly Phe Thr Gly Pro 
            20                  25                  30          


Pro Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Glu Lys Gly Gln Met 
        35                  40                  45              


Gly Leu Ser Phe Gln Gly Pro Lys Gly Asp Lys Gly Asp Gln Gly Val 
    50                  55                  60                  


Ser Gly Pro Pro Gly Val Pro Gly Gln Ala Gln Val Gln Glu Lys Gly 
65                  70                  75                  80  


Asp Phe Ala Thr Lys Gly Glu Lys Gly Gln Lys Gly Glu Pro Gly Phe 
                85                  90                  95      


Gln Gly Met Pro Gly Val Gly Glu Lys Gly Glu Pro Gly Lys Pro Gly 
            100                 105                 110         


Pro Arg Gly Lys Pro Gly Lys Asp Gly Asp Lys Gly Glu Lys Gly Ser 
        115                 120                 125             


Pro Gly Phe Pro Gly Glu Pro Gly Tyr Pro Gly Leu Ile Gly Arg Gln 
    130                 135                 140                 


Gly Pro Gln Gly Glu Lys Gly Glu Ala Gly Pro Pro Gly Pro Pro Gly 
145                 150                 155                 160 


Ile Val Ile Gly Thr Gly Pro Leu Gly Glu Lys Gly Glu Arg Gly Tyr 
                165                 170                 175     


Pro Gly Thr Pro Gly Pro Arg Gly Glu Pro Gly Pro Lys Gly Phe Pro 
            180                 185                 190         


Gly Leu Pro Gly Gln Pro Gly Pro Pro Gly Leu Pro Val Pro Gly Gln 
        195                 200                 205             


Ala Gly Ala Pro Gly Phe Pro Gly Glu Arg Gly Glu Lys Gly Asp Arg 
    210                 215                 220                 


Gly Phe Pro Gly Thr Ser Leu Pro Gly Pro Ser Gly Arg Asp Gly Leu 
225                 230                 235                 240 


Pro Gly Pro Pro Gly Ser Pro Gly Pro Pro Gly Gln Pro Gly Tyr Thr 
                245                 250                 255     


Asn Gly Ile Val Glu Cys Gln Pro Gly Pro Pro Gly Asp Gln Gly Pro 
            260                 265                 270         


Pro Gly Ile Pro Gly Gln Pro Gly Phe Ile Gly Glu Ile Gly Glu Lys 
        275                 280                 285             


Gly Gln Lys Gly Glu Ser Cys Leu Ile Cys Asp Ile Asp Gly Tyr Arg 
    290                 295                 300                 


Gly Pro Pro Gly Pro Gln Gly Pro Pro Gly Glu Ile Gly Phe Pro Gly 
305                 310                 315                 320 


Gln Pro Gly Ala Lys Gly Asp Arg Gly Leu Pro Gly Arg Asp Gly Val 
                325                 330                 335     


Ala Gly Val Pro Gly Pro Gln Gly Thr Pro Gly Leu Ile Gly Gln Pro 
            340                 345                 350         


Gly Ala Lys Gly Glu Pro Gly Glu Phe Tyr Phe Asp Leu Arg Leu Lys 
        355                 360                 365             


Gly Asp Lys Gly Asp Pro Gly Phe Pro Gly Gln Pro Gly Met Pro Gly 
    370                 375                 380                 


Arg Ala Gly Ser Pro Gly Arg Asp Gly His Pro Gly Leu Pro Gly Pro 
385                 390                 395                 400 


Lys Gly Ser Pro Gly Ser Val Gly Leu Lys Gly Glu Arg Gly Pro Pro 
                405                 410                 415     


Gly Gly Val Gly Phe Pro Gly Ser Arg Gly Asp Thr Gly Pro Pro Gly 
            420                 425                 430         


Pro Pro Gly Tyr Gly Pro Ala Gly Pro Ile Gly Asp Lys Gly Gln Ala 
        435                 440                 445             


Gly Phe Pro Gly Gly Pro Gly Ser Pro Gly Leu Pro Gly Pro Lys Gly 
    450                 455                 460                 


Glu Pro Gly Lys Ile Val Pro Leu Pro Gly Pro Pro Gly Ala Glu Gly 
465                 470                 475                 480 


Leu Pro Gly Ser Pro Gly Phe Pro Gly Pro Gln Gly Asp Arg Gly Phe 
                485                 490                 495     


Pro Gly Thr Pro Gly Arg Pro Gly Leu Pro Gly Glu Lys Gly Ala Val 
            500                 505                 510         


Gly Gln Pro Gly Ile Gly Phe Pro Gly Pro Pro Gly Pro Lys Gly Val 
        515                 520                 525             


Asp Gly Leu Pro Gly Asp Met Gly Pro Pro Gly Thr Pro Gly Arg Pro 
    530                 535                 540                 


Gly Phe Asn Gly Leu Pro Gly Asn Pro Gly Val Gln Gly Gln Lys Gly 
545                 550                 555                 560 


Glu Pro Gly Val Gly Leu Pro Gly Leu Lys Gly Leu Pro Gly Leu Pro 
                565                 570                 575     


Gly Ile Pro Gly Thr Pro Gly Glu Lys Gly Ser Ile Gly Val Pro Gly 
            580                 585                 590         


Val Pro Gly Glu His Gly Ala Ile Gly Pro Pro Gly Leu Gln Gly Ile 
        595                 600                 605             


Arg Gly Glu Pro Gly Pro Pro Gly Leu Pro Gly Ser Val Gly Ser Pro 
    610                 615                 620                 


Gly Val Pro Gly Ile Gly Pro Pro Gly Ala Arg Gly Pro Pro Gly Gly 
625                 630                 635                 640 


Gln Gly Pro Pro Gly Leu Ser Gly Pro Pro Gly Ile Lys Gly Glu Lys 
                645                 650                 655     


Gly Phe Pro Gly Phe Pro Gly Leu Asp Met Pro Gly Pro Lys Gly Asp 
            660                 665                 670         


Lys Gly Ala Gln Gly Leu Pro Gly Ile Thr Gly Gln Ser Gly Leu Pro 
        675                 680                 685             


Gly Leu Pro Gly Gln Gln Gly Ala Pro Gly Ile Pro Gly Phe Pro Gly 
    690                 695                 700                 


Ser Lys Gly Glu Met Gly Val Met Gly Thr Pro Gly Gln Pro Gly Ser 
705                 710                 715                 720 


Pro Gly Pro Val Gly Ala Pro Gly Leu Pro Gly Glu Lys Gly Asp His 
                725                 730                 735     


Gly Phe Pro Gly Ser Ser Gly Pro Arg Gly Asp Pro Gly Leu Lys Gly 
            740                 745                 750         


Asp Lys Gly Asp Val Gly Leu Pro Gly Lys Pro Gly Ser Met Asp Lys 
        755                 760                 765             


Val Asp Met Gly Ser Met Lys Gly Gln Lys Gly Asp Gln Gly Glu Lys 
    770                 775                 780                 


Gly Gln Ile Gly Pro Ile Gly Glu Lys Gly Ser Arg Gly Asp Pro Gly 
785                 790                 795                 800 


Thr Pro Gly Val Pro Gly Lys Asp Gly Gln Ala Gly Gln Pro Gly Gln 
                805                 810                 815     


Pro Gly Pro Lys Gly Asp Pro Gly Ile Ser Gly Thr Pro Gly Ala Pro 
            820                 825                 830         


Gly Leu Pro Gly Pro Lys Gly Ser Val Gly Gly Met Gly Leu Pro Gly 
        835                 840                 845             


Thr Pro Gly Glu Lys Gly Val Pro Gly Ile Pro Gly Pro Gln Gly Ser 
    850                 855                 860                 


Pro Gly Leu Pro Gly Asp Lys Gly Ala Lys Gly Glu Lys Gly Gln Ala 
865                 870                 875                 880 


Gly Pro Pro Gly Ile Gly Ile Pro Gly Leu Arg Gly Glu Lys Gly Asp 
                885                 890                 895     


Gln Gly Ile Ala Gly Phe Pro Gly Ser Pro Gly Glu Lys Gly Glu Lys 
            900                 905                 910         


Gly Ser Ile Gly Ile Pro Gly Met Pro Gly Ser Pro Gly Leu Lys Gly 
        915                 920                 925             


Ser Pro Gly Ser Val Gly Tyr Pro Gly Ser Pro Gly Leu Pro Gly Glu 
    930                 935                 940                 


Lys Gly Asp Lys Gly Leu Pro Gly Leu Asp Gly Ile Pro Gly Val Lys 
945                 950                 955                 960 


Gly Glu Ala Gly Leu Pro Gly Thr Pro Gly Pro Thr Gly Pro Ala Gly 
                965                 970                 975     


Gln Lys Gly Glu Pro Gly Ser Asp Gly Ile Pro Gly Ser Ala Gly Glu 
            980                 985                 990         


Lys Gly Glu Pro Gly Leu Pro Gly  Arg Gly Phe Pro Gly  Phe Pro Gly 
        995                 1000                 1005             


Ala Lys  Gly Asp Lys Gly Ser  Lys Gly Glu Val Gly  Phe Pro Gly 
    1010                 1015                 1020             


Leu Ala  Gly Ser Pro Gly Ile  Pro Gly Ser Lys Gly  Glu Gln Gly 
    1025                 1030                 1035             


Phe Met  Gly Pro Pro Gly Pro  Gln Gly Gln Pro Gly  Leu Pro Gly 
    1040                 1045                 1050             


Ser Pro  Gly His Ala Thr Glu  Gly Pro Lys Gly Asp  Arg Gly Pro 
    1055                 1060                 1065             


Gln Gly  Gln Pro Gly Leu Pro  Gly Leu Pro Gly Pro  Met Gly Pro 
    1070                 1075                 1080             


Pro Gly  Leu Pro Gly Ile Asp  Gly Val Lys Gly Asp  Lys Gly Asn 
    1085                 1090                 1095             


Pro Gly  Trp Pro Gly Ala Pro  Gly Val Pro Gly Pro  Lys Gly Asp 
    1100                 1105                 1110             


Pro Gly  Phe Gln Gly Met Pro  Gly Ile Gly Gly Ser  Pro Gly Ile 
    1115                 1120                 1125             


Thr Gly  Ser Lys Gly Asp Met  Gly Pro Pro Gly Val  Pro Gly Phe 
    1130                 1135                 1140             


Gln Gly  Pro Lys Gly Leu Pro  Gly Leu Gln Gly Ile  Lys Gly Asp 
    1145                 1150                 1155             


Gln Gly  Asp Gln Gly Val Pro  Gly Ala Lys Gly Leu  Pro Gly Pro 
    1160                 1165                 1170             


Pro Gly  Pro Pro Gly Pro Tyr  Asp Ile Ile Lys Gly  Glu Pro Gly 
    1175                 1180                 1185             


Leu Pro  Gly Pro Glu Gly Pro  Pro Gly Leu Lys Gly  Leu Gln Gly 
    1190                 1195                 1200             


Leu Pro  Gly Pro Lys Gly Gln  Gln Gly Val Thr Gly  Leu Val Gly 
    1205                 1210                 1215             


Ile Pro  Gly Pro Pro Gly Ile  Pro Gly Phe Asp Gly  Ala Pro Gly 
    1220                 1225                 1230             


Gln Lys  Gly Glu Met Gly Pro  Ala Gly Pro Thr Gly  Pro Arg Gly 
    1235                 1240                 1245             


Phe Pro  Gly Pro Pro Gly Pro  Asp Gly Leu Pro Gly  Ser Met Gly 
    1250                 1255                 1260             


Pro Pro  Gly Thr Pro Ser Val  Asp His Gly Phe Leu  Val Thr Arg 
    1265                 1270                 1275             


His Ser  Gln Thr Ile Asp Asp  Pro Gln Cys Pro Ser  Gly Thr Lys 
    1280                 1285                 1290             


Ile Leu  Tyr His Gly Tyr Ser  Leu Leu Tyr Val Gln  Gly Asn Glu 
    1295                 1300                 1305             


Arg Ala  His Gly Gln Asp Leu  Gly Thr Ala Gly Ser  Cys Leu Arg 
    1310                 1315                 1320             


Lys Phe  Ser Thr Met Pro Phe  Leu Phe Cys Asn Ile  Asn Asn Val 
    1325                 1330                 1335             


Cys Asn  Phe Ala Ser Arg Asn  Asp Tyr Ser Tyr Trp  Leu Ser Thr 
    1340                 1345                 1350             


Pro Glu  Pro Met Pro Met Ser  Met Ala Pro Ile Thr  Gly Glu Asn 
    1355                 1360                 1365             


Ile Arg  Pro Phe Ile Ser Arg  Cys Ala Val Cys Glu  Ala Pro Ala 
    1370                 1375                 1380             


Met Val  Met Ala Val His Ser  Gln Thr Ile Gln Ile  Pro Pro Cys 
    1385                 1390                 1395             


Pro Ser  Gly Trp Ser Ser Leu  Trp Ile Gly Tyr Ser  Phe Val Met 
    1400                 1405                 1410             


His Thr  Ser Ala Gly Ala Glu  Gly Ser Gly Gln Ala  Leu Ala Ser 
    1415                 1420                 1425             


Pro Gly  Ser Cys Leu Glu Glu  Phe Arg Ser Ala Pro  Phe Ile Glu 
    1430                 1435                 1440             


Cys His  Gly Arg Gly Thr Cys  Asn Tyr Tyr Ala Asn  Ala Tyr Ser 
    1445                 1450                 1455             


Phe Trp  Leu Ala Thr Ile Glu  Arg Ser Glu Met Phe  Lys Lys Pro 
    1460                 1465                 1470             


Thr Pro  Ser Thr Leu Lys Ala  Gly Glu Leu Arg Thr  His Val Ser 
    1475                 1480                 1485             


Arg Cys  Gln Val Cys Met Arg  Arg Thr 
    1490                 1495         


<210>  5
<211>  288
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Val Gly Val Gly Gly Gly Asp Val Glu Asp Val Thr Pro Arg Pro 
1               5                   10                  15      


Gly Gly Cys Gln Ile Ser Gly Arg Gly Ala Arg Gly Cys Asn Gly Ile 
            20                  25                  30          


Pro Gly Ala Ala Ala Trp Glu Ala Ala Leu Pro Arg Arg Arg Pro Arg 
        35                  40                  45              


Arg His Pro Ser Val Asn Pro Arg Ser Arg Ala Ala Gly Ser Pro Arg 
    50                  55                  60                  


Thr Arg Gly Arg Arg Thr Glu Glu Arg Pro Ser Gly Ser Arg Leu Gly 
65                  70                  75                  80  


Asp Arg Gly Arg Gly Arg Ala Leu Pro Gly Gly Arg Leu Gly Gly Arg 
                85                  90                  95      


Gly Arg Gly Arg Ala Pro Glu Arg Val Gly Gly Arg Gly Arg Gly Arg 
            100                 105                 110         


Gly Thr Ala Ala Pro Arg Ala Ala Pro Ala Ala Arg Gly Ser Arg Pro 
        115                 120                 125             


Gly Pro Ala Gly Thr Met Ala Ala Gly Ser Ile Thr Thr Leu Pro Ala 
    130                 135                 140                 


Leu Pro Glu Asp Gly Gly Ser Gly Ala Phe Pro Pro Gly His Phe Lys 
145                 150                 155                 160 


Asp Pro Lys Arg Leu Tyr Cys Lys Asn Gly Gly Phe Phe Leu Arg Ile 
                165                 170                 175     


His Pro Asp Gly Arg Val Asp Gly Val Arg Glu Lys Ser Asp Pro His 
            180                 185                 190         


Ile Lys Leu Gln Leu Gln Ala Glu Glu Arg Gly Val Val Ser Ile Lys 
        195                 200                 205             


Gly Val Cys Ala Asn Arg Tyr Leu Ala Met Lys Glu Asp Gly Arg Leu 
    210                 215                 220                 


Leu Ala Ser Lys Cys Val Thr Asp Glu Cys Phe Phe Phe Glu Arg Leu 
225                 230                 235                 240 


Glu Ser Asn Asn Tyr Asn Thr Tyr Arg Ser Arg Lys Tyr Thr Ser Trp 
                245                 250                 255     


Tyr Val Ala Leu Lys Arg Thr Gly Gln Tyr Lys Leu Gly Ser Lys Thr 
            260                 265                 270         


Gly Pro Gly Gln Lys Ala Ile Leu Phe Leu Pro Met Ser Ala Lys Ser 
        275                 280                 285             


<210>  6
<211>  2415
<212>  PRT
<213>  Homo sapiens

<400>  6

Gln Ala Gln Gln Met Val Gln Pro Gln Ser Pro Val Ala Val Ser Gln 
1               5                   10                  15      


Ser Lys Pro Gly Cys Tyr Asp Asn Gly Lys His Tyr Gln Ile Asn Gln 
            20                  25                  30          


Gln Trp Glu Arg Thr Tyr Leu Gly Asn Ala Leu Val Cys Thr Cys Tyr 
        35                  40                  45              


Gly Gly Ser Arg Gly Phe Asn Cys Glu Ser Lys Pro Glu Ala Glu Glu 
    50                  55                  60                  


Thr Cys Phe Asp Lys Tyr Thr Gly Asn Thr Tyr Arg Val Gly Asp Thr 
65                  70                  75                  80  


Tyr Glu Arg Pro Lys Asp Ser Met Ile Trp Asp Cys Thr Cys Ile Gly 
                85                  90                  95      


Ala Gly Arg Gly Arg Ile Ser Cys Thr Ile Ala Asn Arg Cys His Glu 
            100                 105                 110         


Gly Gly Gln Ser Tyr Lys Ile Gly Asp Thr Trp Arg Arg Pro His Glu 
        115                 120                 125             


Thr Gly Gly Tyr Met Leu Glu Cys Val Cys Leu Gly Asn Gly Lys Gly 
    130                 135                 140                 


Glu Trp Thr Cys Lys Pro Ile Ala Glu Lys Cys Phe Asp His Ala Ala 
145                 150                 155                 160 


Gly Thr Ser Tyr Val Val Gly Glu Thr Trp Glu Lys Pro Tyr Gln Gly 
                165                 170                 175     


Trp Met Met Val Asp Cys Thr Cys Leu Gly Glu Gly Ser Gly Arg Ile 
            180                 185                 190         


Thr Cys Thr Ser Arg Asn Arg Cys Asn Asp Gln Asp Thr Arg Thr Ser 
        195                 200                 205             


Tyr Arg Ile Gly Asp Thr Trp Ser Lys Lys Asp Asn Arg Gly Asn Leu 
    210                 215                 220                 


Leu Gln Cys Ile Cys Thr Gly Asn Gly Arg Gly Glu Trp Lys Cys Glu 
225                 230                 235                 240 


Arg His Thr Ser Val Gln Thr Thr Ser Ser Gly Ser Gly Pro Phe Thr 
                245                 250                 255     


Asp Val Arg Ala Ala Val Tyr Gln Pro Gln Pro His Pro Gln Pro Pro 
            260                 265                 270         


Pro Tyr Gly His Cys Val Thr Asp Ser Gly Val Val Tyr Ser Val Gly 
        275                 280                 285             


Met Gln Trp Leu Lys Thr Gln Gly Asn Lys Gln Met Leu Cys Thr Cys 
    290                 295                 300                 


Leu Gly Asn Gly Val Ser Cys Gln Glu Thr Ala Val Thr Gln Thr Tyr 
305                 310                 315                 320 


Gly Gly Asn Ser Asn Gly Glu Pro Cys Val Leu Pro Phe Thr Tyr Asn 
                325                 330                 335     


Gly Arg Thr Phe Tyr Ser Cys Thr Thr Glu Gly Arg Gln Asp Gly His 
            340                 345                 350         


Leu Trp Cys Ser Thr Thr Ser Asn Tyr Glu Gln Asp Gln Lys Tyr Ser 
        355                 360                 365             


Phe Cys Thr Asp His Thr Val Leu Val Gln Thr Arg Gly Gly Asn Ser 
    370                 375                 380                 


Asn Gly Ala Leu Cys His Phe Pro Phe Leu Tyr Asn Asn His Asn Tyr 
385                 390                 395                 400 


Thr Asp Cys Thr Ser Glu Gly Arg Arg Asp Asn Met Lys Trp Cys Gly 
                405                 410                 415     


Thr Thr Gln Asn Tyr Asp Ala Asp Gln Lys Phe Gly Phe Cys Pro Met 
            420                 425                 430         


Ala Ala His Glu Glu Ile Cys Thr Thr Asn Glu Gly Val Met Tyr Arg 
        435                 440                 445             


Ile Gly Asp Gln Trp Asp Lys Gln His Asp Met Gly His Met Met Arg 
    450                 455                 460                 


Cys Thr Cys Val Gly Asn Gly Arg Gly Glu Trp Thr Cys Ile Ala Tyr 
465                 470                 475                 480 


Ser Gln Leu Arg Asp Gln Cys Ile Val Asp Asp Ile Thr Tyr Asn Val 
                485                 490                 495     


Asn Asp Thr Phe His Lys Arg His Glu Glu Gly His Met Leu Asn Cys 
            500                 505                 510         


Thr Cys Phe Gly Gln Gly Arg Gly Arg Trp Lys Cys Asp Pro Val Asp 
        515                 520                 525             


Gln Cys Gln Asp Ser Glu Thr Gly Thr Phe Tyr Gln Ile Gly Asp Ser 
    530                 535                 540                 


Trp Glu Lys Tyr Val His Gly Val Arg Tyr Gln Cys Tyr Cys Tyr Gly 
545                 550                 555                 560 


Arg Gly Ile Gly Glu Trp His Cys Gln Pro Leu Gln Thr Tyr Pro Ser 
                565                 570                 575     


Ser Ser Gly Pro Val Glu Val Phe Ile Thr Glu Thr Pro Ser Gln Pro 
            580                 585                 590         


Asn Ser His Pro Ile Gln Trp Asn Ala Pro Gln Pro Ser His Ile Ser 
        595                 600                 605             


Lys Tyr Ile Leu Arg Trp Arg Pro Lys Asn Ser Val Gly Arg Trp Lys 
    610                 615                 620                 


Glu Ala Thr Ile Pro Gly His Leu Asn Ser Tyr Thr Ile Lys Gly Leu 
625                 630                 635                 640 


Lys Pro Gly Val Val Tyr Glu Gly Gln Leu Ile Ser Ile Gln Gln Tyr 
                645                 650                 655     


Gly His Gln Glu Val Thr Arg Phe Asp Phe Thr Thr Thr Ser Thr Ser 
            660                 665                 670         


Thr Pro Val Thr Ser Asn Thr Val Thr Gly Glu Thr Thr Pro Phe Ser 
        675                 680                 685             


Pro Leu Val Ala Thr Ser Glu Ser Val Thr Glu Ile Thr Ala Ser Ser 
    690                 695                 700                 


Phe Val Val Ser Trp Val Ser Ala Ser Asp Thr Val Ser Gly Phe Arg 
705                 710                 715                 720 


Val Glu Tyr Glu Leu Ser Glu Glu Gly Asp Glu Pro Gln Tyr Leu Asp 
                725                 730                 735     


Leu Pro Ser Thr Ala Thr Ser Val Asn Ile Pro Asp Leu Leu Pro Gly 
            740                 745                 750         


Arg Lys Tyr Ile Val Asn Val Tyr Gln Ile Ser Glu Asp Gly Glu Gln 
        755                 760                 765             


Ser Leu Ile Leu Ser Thr Ser Gln Thr Thr Ala Pro Asp Ala Pro Pro 
    770                 775                 780                 


Asp Pro Thr Val Asp Gln Val Asp Asp Thr Ser Ile Val Val Arg Trp 
785                 790                 795                 800 


Ser Arg Pro Gln Ala Pro Ile Thr Gly Tyr Arg Ile Val Tyr Ser Pro 
                805                 810                 815     


Ser Val Glu Gly Ser Ser Thr Glu Leu Asn Leu Pro Glu Thr Ala Asn 
            820                 825                 830         


Ser Val Thr Leu Ser Asp Leu Gln Pro Gly Val Gln Tyr Asn Ile Thr 
        835                 840                 845             


Ile Tyr Ala Val Glu Glu Asn Gln Glu Ser Thr Pro Val Val Ile Gln 
    850                 855                 860                 


Gln Glu Thr Thr Gly Thr Pro Arg Ser Asp Thr Val Pro Ser Pro Arg 
865                 870                 875                 880 


Asp Leu Gln Phe Val Glu Val Thr Asp Val Lys Val Thr Ile Met Trp 
                885                 890                 895     


Thr Pro Pro Glu Ser Ala Val Thr Gly Tyr Arg Val Asp Val Ile Pro 
            900                 905                 910         


Val Asn Leu Pro Gly Glu His Gly Gln Arg Leu Pro Ile Ser Arg Asn 
        915                 920                 925             


Thr Phe Ala Glu Val Thr Gly Leu Ser Pro Gly Val Thr Tyr Tyr Phe 
    930                 935                 940                 


Lys Val Phe Ala Val Ser His Gly Arg Glu Ser Lys Pro Leu Thr Ala 
945                 950                 955                 960 


Gln Gln Thr Thr Lys Leu Asp Ala Pro Thr Asn Leu Gln Phe Val Asn 
                965                 970                 975     


Glu Thr Asp Ser Thr Val Leu Val Arg Trp Thr Pro Pro Arg Ala Gln 
            980                 985                 990         


Ile Thr Gly Tyr Arg Leu Thr Val  Gly Leu Thr Arg Arg  Gly Gln Pro 
        995                 1000                 1005             


Arg Gln  Tyr Asn Val Gly Pro  Ser Val Ser Lys Tyr  Pro Leu Arg 
    1010                 1015                 1020             


Asn Leu  Gln Pro Ala Ser Glu  Tyr Thr Val Ser Leu  Val Ala Ile 
    1025                 1030                 1035             


Lys Gly  Asn Gln Glu Ser Pro  Lys Ala Thr Gly Val  Phe Thr Thr 
    1040                 1045                 1050             


Leu Gln  Pro Gly Ser Ser Ile  Pro Pro Tyr Asn Thr  Glu Val Thr 
    1055                 1060                 1065             


Glu Thr  Thr Ile Val Ile Thr  Trp Thr Pro Ala Pro  Arg Ile Gly 
    1070                 1075                 1080             


Phe Lys  Leu Gly Val Arg Pro  Ser Gln Gly Gly Glu  Ala Pro Arg 
    1085                 1090                 1095             


Glu Val  Thr Ser Asp Ser Gly  Ser Ile Val Val Ser  Gly Leu Thr 
    1100                 1105                 1110             


Pro Gly  Val Glu Tyr Val Tyr  Thr Ile Gln Val Leu  Arg Asp Gly 
    1115                 1120                 1125             


Gln Glu  Arg Asp Ala Pro Ile  Val Asn Lys Val Val  Thr Pro Leu 
    1130                 1135                 1140             


Ser Pro  Pro Thr Asn Leu His  Leu Glu Ala Asn Pro  Asp Thr Gly 
    1145                 1150                 1155             


Val Leu  Thr Val Ser Trp Glu  Arg Ser Thr Thr Pro  Asp Ile Thr 
    1160                 1165                 1170             


Gly Tyr  Arg Ile Thr Thr Thr  Pro Thr Asn Gly Gln  Gln Gly Asn 
    1175                 1180                 1185             


Ser Leu  Glu Glu Val Val His  Ala Asp Gln Ser Ser  Cys Thr Phe 
    1190                 1195                 1200             


Asp Asn  Leu Ser Pro Gly Leu  Glu Tyr Asn Val Ser  Val Tyr Thr 
    1205                 1210                 1215             


Val Lys  Asp Asp Lys Glu Ser  Val Pro Ile Ser Asp  Thr Ile Ile 
    1220                 1225                 1230             


Pro Glu  Val Pro Gln Leu Thr  Asp Leu Ser Phe Val  Asp Ile Thr 
    1235                 1240                 1245             


Asp Ser  Ser Ile Gly Leu Arg  Trp Thr Pro Leu Asn  Ser Ser Thr 
    1250                 1255                 1260             


Ile Ile  Gly Tyr Arg Ile Thr  Val Val Ala Ala Gly  Glu Gly Ile 
    1265                 1270                 1275             


Pro Ile  Phe Glu Asp Phe Val  Asp Ser Ser Val Gly  Tyr Tyr Thr 
    1280                 1285                 1290             


Val Thr  Gly Leu Glu Pro Gly  Ile Asp Tyr Asp Ile  Ser Val Ile 
    1295                 1300                 1305             


Thr Leu  Ile Asn Gly Gly Glu  Ser Ala Pro Thr Thr  Leu Thr Gln 
    1310                 1315                 1320             


Gln Thr  Ala Val Pro Pro Pro  Thr Asp Leu Arg Phe  Thr Asn Ile 
    1325                 1330                 1335             


Gly Pro  Asp Thr Met Arg Val  Thr Trp Ala Pro Pro  Pro Ser Ile 
    1340                 1345                 1350             


Asp Leu  Thr Asn Phe Leu Val  Arg Tyr Ser Pro Val  Lys Asn Glu 
    1355                 1360                 1365             


Glu Asp  Val Ala Glu Leu Ser  Ile Ser Pro Ser Asp  Asn Ala Val 
    1370                 1375                 1380             


Val Leu  Thr Asn Leu Leu Pro  Gly Thr Glu Tyr Val  Val Ser Val 
    1385                 1390                 1395             


Ser Ser  Val Tyr Glu Gln His  Glu Ser Thr Pro Leu  Arg Gly Arg 
    1400                 1405                 1410             


Gln Lys  Thr Gly Leu Asp Ser  Pro Thr Gly Ile Asp  Phe Ser Asp 
    1415                 1420                 1425             


Ile Thr  Ala Asn Ser Phe Thr  Val His Trp Ile Ala  Pro Arg Ala 
    1430                 1435                 1440             


Thr Ile  Thr Gly Tyr Arg Ile  Arg His His Pro Glu  His Phe Ser 
    1445                 1450                 1455             


Gly Arg  Pro Arg Glu Asp Arg  Val Pro His Ser Arg  Asn Ser Ile 
    1460                 1465                 1470             


Thr Leu  Thr Asn Leu Thr Pro  Gly Thr Glu Tyr Val  Val Ser Ile 
    1475                 1480                 1485             


Val Ala  Leu Asn Gly Arg Glu  Glu Ser Pro Leu Leu  Ile Gly Gln 
    1490                 1495                 1500             


Gln Ser  Thr Val Ser Asp Val  Pro Arg Asp Leu Glu  Val Val Ala 
    1505                 1510                 1515             


Ala Thr  Pro Thr Ser Leu Leu  Ile Ser Trp Asp Ala  Pro Ala Val 
    1520                 1525                 1530             


Thr Val  Arg Tyr Tyr Arg Ile  Thr Tyr Gly Glu Thr  Gly Gly Asn 
    1535                 1540                 1545             


Ser Pro  Val Gln Glu Phe Thr  Val Pro Gly Ser Lys  Ser Thr Ala 
    1550                 1555                 1560             


Thr Ile  Ser Gly Leu Lys Pro  Gly Val Asp Tyr Thr  Ile Thr Val 
    1565                 1570                 1575             


Tyr Ala  Val Thr Gly Arg Gly  Asp Ser Pro Ala Ser  Ser Lys Pro 
    1580                 1585                 1590             


Ile Ser  Ile Asn Tyr Arg Thr  Glu Ile Asp Lys Pro  Ser Gln Met 
    1595                 1600                 1605             


Gln Val  Thr Asp Val Gln Asp  Asn Ser Ile Ser Val  Lys Trp Leu 
    1610                 1615                 1620             


Pro Ser  Ser Ser Pro Val Thr  Gly Tyr Arg Val Thr  Thr Thr Pro 
    1625                 1630                 1635             


Lys Asn  Gly Pro Gly Pro Thr  Lys Thr Lys Thr Ala  Gly Pro Asp 
    1640                 1645                 1650             


Gln Thr  Glu Met Thr Ile Glu  Gly Leu Gln Pro Thr  Val Glu Tyr 
    1655                 1660                 1665             


Val Val  Ser Val Tyr Ala Gln  Asn Pro Ser Gly Glu  Ser Gln Pro 
    1670                 1675                 1680             


Leu Val  Gln Thr Ala Val Thr  Asn Ile Asp Arg Pro  Lys Gly Leu 
    1685                 1690                 1695             


Ala Phe  Thr Asp Val Asp Val  Asp Ser Ile Lys Ile  Ala Trp Glu 
    1700                 1705                 1710             


Ser Pro  Gln Gly Gln Val Ser  Arg Tyr Arg Val Thr  Tyr Ser Ser 
    1715                 1720                 1725             


Pro Glu  Asp Gly Ile His Glu  Leu Phe Pro Ala Pro  Asp Gly Glu 
    1730                 1735                 1740             


Glu Asp  Thr Ala Glu Leu Gln  Gly Leu Arg Pro Gly  Ser Glu Tyr 
    1745                 1750                 1755             


Thr Val  Ser Val Val Ala Leu  His Asp Asp Met Glu  Ser Gln Pro 
    1760                 1765                 1770             


Leu Ile  Gly Thr Gln Ser Thr  Ala Ile Pro Ala Pro  Thr Asp Leu 
    1775                 1780                 1785             


Lys Phe  Thr Gln Val Thr Pro  Thr Ser Leu Ser Ala  Gln Trp Thr 
    1790                 1795                 1800             


Pro Pro  Asn Val Gln Leu Thr  Gly Tyr Arg Val Arg  Val Thr Pro 
    1805                 1810                 1815             


Lys Glu  Lys Thr Gly Pro Met  Lys Glu Ile Asn Leu  Ala Pro Asp 
    1820                 1825                 1830             


Ser Ser  Ser Val Val Val Ser  Gly Leu Met Val Ala  Thr Lys Tyr 
    1835                 1840                 1845             


Glu Val  Ser Val Tyr Ala Leu  Lys Asp Thr Leu Thr  Ser Arg Pro 
    1850                 1855                 1860             


Ala Gln  Gly Val Val Thr Thr  Leu Glu Asn Val Ser  Pro Pro Arg 
    1865                 1870                 1875             


Arg Ala  Arg Val Thr Asp Ala  Thr Glu Thr Thr Ile  Thr Ile Ser 
    1880                 1885                 1890             


Trp Arg  Thr Lys Thr Glu Thr  Ile Thr Gly Phe Gln  Val Asp Ala 
    1895                 1900                 1905             


Val Pro  Ala Asn Gly Gln Thr  Pro Ile Gln Arg Thr  Ile Lys Pro 
    1910                 1915                 1920             


Asp Val  Arg Ser Tyr Thr Ile  Thr Gly Leu Gln Pro  Gly Thr Asp 
    1925                 1930                 1935             


Tyr Lys  Ile Tyr Leu Tyr Thr  Leu Asn Asp Asn Ala  Arg Ser Ser 
    1940                 1945                 1950             


Pro Val  Val Ile Asp Ala Ser  Thr Ala Ile Asp Ala  Pro Ser Asn 
    1955                 1960                 1965             


Leu Arg  Phe Leu Ala Thr Thr  Pro Asn Ser Leu Leu  Val Ser Trp 
    1970                 1975                 1980             


Gln Pro  Pro Arg Ala Arg Ile  Thr Gly Tyr Ile Ile  Lys Tyr Glu 
    1985                 1990                 1995             


Lys Pro  Gly Ser Pro Pro Arg  Glu Val Val Pro Arg  Pro Arg Pro 
    2000                 2005                 2010             


Gly Val  Thr Glu Ala Thr Ile  Thr Gly Leu Glu Pro  Gly Thr Glu 
    2015                 2020                 2025             


Tyr Thr  Ile Tyr Val Ile Ala  Leu Lys Asn Asn Gln  Lys Ser Glu 
    2030                 2035                 2040             


Pro Leu  Ile Gly Arg Lys Lys  Thr Asp Glu Leu Pro  Gln Leu Val 
    2045                 2050                 2055             


Thr Leu  Pro His Pro Asn Leu  His Gly Pro Glu Ile  Leu Asp Val 
    2060                 2065                 2070             


Pro Ser  Thr Val Gln Lys Thr  Pro Phe Val Thr His  Pro Gly Tyr 
    2075                 2080                 2085             


Asp Thr  Gly Asn Gly Ile Gln  Leu Pro Gly Thr Ser  Gly Gln Gln 
    2090                 2095                 2100             


Pro Ser  Val Gly Gln Gln Met  Ile Phe Glu Glu His  Gly Phe Arg 
    2105                 2110                 2115             


Arg Thr  Thr Pro Pro Thr Thr  Ala Thr Pro Ile Arg  His Arg Pro 
    2120                 2125                 2130             


Arg Pro  Tyr Pro Pro Asn Val  Gly Gln Glu Ala Leu  Ser Gln Thr 
    2135                 2140                 2145             


Thr Ile  Ser Trp Ala Pro Phe  Gln Asp Thr Ser Glu  Tyr Ile Ile 
    2150                 2155                 2160             


Ser Cys  His Pro Val Gly Thr  Asp Glu Glu Pro Leu  Gln Phe Arg 
    2165                 2170                 2175             


Val Pro  Gly Thr Ser Thr Ser  Ala Thr Leu Thr Gly  Leu Thr Arg 
    2180                 2185                 2190             


Gly Ala  Thr Tyr Asn Ile Ile  Val Glu Ala Leu Lys  Asp Gln Gln 
    2195                 2200                 2205             


Arg His  Lys Val Arg Glu Glu  Val Val Thr Val Gly  Asn Ser Val 
    2210                 2215                 2220             


Asn Glu  Gly Leu Asn Gln Pro  Thr Asp Asp Ser Cys  Phe Asp Pro 
    2225                 2230                 2235             


Tyr Thr  Val Ser His Tyr Ala  Val Gly Asp Glu Trp  Glu Arg Met 
    2240                 2245                 2250             


Ser Glu  Ser Gly Phe Lys Leu  Leu Cys Gln Cys Leu  Gly Phe Gly 
    2255                 2260                 2265             


Ser Gly  His Phe Arg Cys Asp  Ser Ser Arg Trp Cys  His Asp Asn 
    2270                 2275                 2280             


Gly Val  Asn Tyr Lys Ile Gly  Glu Lys Trp Asp Arg  Gln Gly Glu 
    2285                 2290                 2295             


Asn Gly  Gln Met Met Ser Cys  Thr Cys Leu Gly Asn  Gly Lys Gly 
    2300                 2305                 2310             


Glu Phe  Lys Cys Asp Pro His  Glu Ala Thr Cys Tyr  Asp Asp Gly 
    2315                 2320                 2325             


Lys Thr  Tyr His Val Gly Glu  Gln Trp Gln Lys Glu  Tyr Leu Gly 
    2330                 2335                 2340             


Ala Ile  Cys Ser Cys Thr Cys  Phe Gly Gly Gln Arg  Gly Trp Arg 
    2345                 2350                 2355             


Cys Asp  Asn Cys Arg Arg Pro  Gly Gly Glu Pro Ser  Pro Glu Gly 
    2360                 2365                 2370             


Thr Thr  Gly Gln Ser Tyr Asn  Gln Tyr Ser Gln Arg  Tyr His Gln 
    2375                 2380                 2385             


Arg Thr  Asn Thr Asn Val Asn  Cys Pro Ile Glu Cys  Phe Met Pro 
    2390                 2395                 2400             


Leu Asp  Val Gln Ala Asp Arg  Glu Asp Ser Arg Glu  
    2405                 2410                 2415 


<210>  7
<211>  109
<212>  PRT
<213>  Homo sapiens

<400>  7

Ser Leu Gly Ser Leu Thr Ile Ala Glu Pro Ala Met Ile Ala Glu Cys 
1               5                   10                  15      


Lys Thr Arg Thr Glu Val Phe Glu Ile Ser Arg Arg Leu Ile Asp Arg 
            20                  25                  30          


Thr Asn Ala Asn Phe Leu Val Trp Pro Pro Cys Val Glu Val Gln Arg 
        35                  40                  45              


Cys Ser Gly Cys Cys Asn Asn Arg Asn Val Gln Cys Arg Pro Thr Gln 
    50                  55                  60                  


Val Gln Leu Arg Pro Val Gln Val Arg Lys Ile Glu Ile Val Arg Lys 
65                  70                  75                  80  


Lys Pro Ile Phe Lys Lys Ala Thr Val Thr Leu Glu Asp His Leu Ala 
                85                  90                  95      


Cys Lys Cys Glu Thr Val Ala Ala Ala Arg Pro Val Thr 
            100                 105                 


<210>  8
<211>  2179
<212>  PRT
<213>  Homo sapiens

<400>  8

Gly Val Leu Lys Lys Val Ile Arg His Lys Arg Gln Ser Gly Val Asn 
1               5                   10                  15      


Ala Thr Leu Pro Glu Glu Asn Gln Pro Val Val Phe Asn His Val Tyr 
            20                  25                  30          


Asn Ile Lys Leu Pro Val Gly Ser Gln Cys Ser Val Asp Leu Glu Ser 
        35                  40                  45              


Ala Ser Gly Glu Lys Asp Leu Ala Pro Pro Ser Glu Pro Ser Glu Ser 
    50                  55                  60                  


Phe Gln Glu His Thr Val Asp Gly Glu Asn Gln Ile Val Phe Thr His 
65                  70                  75                  80  


Arg Ile Asn Ile Pro Arg Arg Ala Cys Gly Cys Ala Ala Ala Pro Asp 
                85                  90                  95      


Val Lys Glu Leu Leu Ser Arg Leu Glu Glu Leu Glu Asn Leu Val Ser 
            100                 105                 110         


Ser Leu Arg Glu Gln Cys Thr Ala Gly Ala Gly Cys Cys Leu Gln Pro 
        115                 120                 125             


Ala Thr Gly Arg Leu Asp Thr Arg Pro Phe Cys Ser Gly Arg Gly Asn 
    130                 135                 140                 


Phe Ser Thr Glu Gly Cys Gly Cys Val Cys Glu Pro Gly Trp Lys Gly 
145                 150                 155                 160 


Pro Asn Cys Ser Glu Pro Glu Cys Pro Gly Asn Cys His Leu Arg Gly 
                165                 170                 175     


Arg Cys Ile Asp Gly Gln Cys Ile Cys Asp Asp Gly Phe Thr Gly Glu 
            180                 185                 190         


Asp Cys Ser Gln Leu Ala Cys Pro Ser Asp Cys Asn Asp Gln Gly Lys 
        195                 200                 205             


Cys Val Asn Gly Val Cys Ile Cys Phe Glu Gly Tyr Ala Gly Ala Asp 
    210                 215                 220                 


Cys Ser Arg Glu Ile Cys Pro Val Pro Cys Ser Glu Glu His Gly Thr 
225                 230                 235                 240 


Cys Val Asp Gly Leu Cys Val Cys His Asp Gly Phe Ala Gly Asp Asp 
                245                 250                 255     


Cys Asn Lys Pro Leu Cys Leu Asn Asn Cys Tyr Asn Arg Gly Arg Cys 
            260                 265                 270         


Val Glu Asn Glu Cys Val Cys Asp Glu Gly Phe Thr Gly Glu Asp Cys 
        275                 280                 285             


Ser Glu Leu Ile Cys Pro Asn Asp Cys Phe Asp Arg Gly Arg Cys Ile 
    290                 295                 300                 


Asn Gly Thr Cys Tyr Cys Glu Glu Gly Phe Thr Gly Glu Asp Cys Gly 
305                 310                 315                 320 


Lys Pro Thr Cys Pro His Ala Cys His Thr Gln Gly Arg Cys Glu Glu 
                325                 330                 335     


Gly Gln Cys Val Cys Asp Glu Gly Phe Ala Gly Val Asp Cys Ser Glu 
            340                 345                 350         


Lys Arg Cys Pro Ala Asp Cys His Asn Arg Gly Arg Cys Val Asp Gly 
        355                 360                 365             


Arg Cys Glu Cys Asp Asp Gly Phe Thr Gly Ala Asp Cys Gly Glu Leu 
    370                 375                 380                 


Lys Cys Pro Asn Gly Cys Ser Gly His Gly Arg Cys Val Asn Gly Gln 
385                 390                 395                 400 


Cys Val Cys Asp Glu Gly Tyr Thr Gly Glu Asp Cys Ser Gln Leu Arg 
                405                 410                 415     


Cys Pro Asn Asp Cys His Ser Arg Gly Arg Cys Val Glu Gly Lys Cys 
            420                 425                 430         


Val Cys Glu Gln Gly Phe Lys Gly Tyr Asp Cys Ser Asp Met Ser Cys 
        435                 440                 445             


Pro Asn Asp Cys His Gln His Gly Arg Cys Val Asn Gly Met Cys Val 
    450                 455                 460                 


Cys Asp Asp Gly Tyr Thr Gly Glu Asp Cys Arg Asp Arg Gln Cys Pro 
465                 470                 475                 480 


Arg Asp Cys Ser Asn Arg Gly Leu Cys Val Asp Gly Gln Cys Val Cys 
                485                 490                 495     


Glu Asp Gly Phe Thr Gly Pro Asp Cys Ala Glu Leu Ser Cys Pro Asn 
            500                 505                 510         


Asp Cys His Gly Gln Gly Arg Cys Val Asn Gly Gln Cys Val Cys His 
        515                 520                 525             


Glu Gly Phe Met Gly Lys Asp Cys Lys Glu Gln Arg Cys Pro Ser Asp 
    530                 535                 540                 


Cys His Gly Gln Gly Arg Cys Val Asp Gly Gln Cys Ile Cys His Glu 
545                 550                 555                 560 


Gly Phe Thr Gly Leu Asp Cys Gly Gln His Ser Cys Pro Ser Asp Cys 
                565                 570                 575     


Asn Asn Leu Gly Gln Cys Val Ser Gly Arg Cys Ile Cys Asn Glu Gly 
            580                 585                 590         


Tyr Ser Gly Glu Asp Cys Ser Glu Val Ser Pro Pro Lys Asp Leu Val 
        595                 600                 605             


Val Thr Glu Val Thr Glu Glu Thr Val Asn Leu Ala Trp Asp Asn Glu 
    610                 615                 620                 


Met Arg Val Thr Glu Tyr Leu Val Val Tyr Thr Pro Thr His Glu Gly 
625                 630                 635                 640 


Gly Leu Glu Met Gln Phe Arg Val Pro Gly Asp Gln Thr Ser Thr Ile 
                645                 650                 655     


Ile Gln Glu Leu Glu Pro Gly Val Glu Tyr Phe Ile Arg Val Phe Ala 
            660                 665                 670         


Ile Leu Glu Asn Lys Lys Ser Ile Pro Val Ser Ala Arg Val Ala Thr 
        675                 680                 685             


Tyr Leu Pro Ala Pro Glu Gly Leu Lys Phe Lys Ser Ile Lys Glu Thr 
    690                 695                 700                 


Ser Val Glu Val Glu Trp Asp Pro Leu Asp Ile Ala Phe Glu Thr Trp 
705                 710                 715                 720 


Glu Ile Ile Phe Arg Asn Met Asn Lys Glu Asp Glu Gly Glu Ile Thr 
                725                 730                 735     


Lys Ser Leu Arg Arg Pro Glu Thr Ser Tyr Arg Gln Thr Gly Leu Ala 
            740                 745                 750         


Pro Gly Gln Glu Tyr Glu Ile Ser Leu His Ile Val Lys Asn Asn Thr 
        755                 760                 765             


Arg Gly Pro Gly Leu Lys Arg Val Thr Thr Thr Arg Leu Asp Ala Pro 
    770                 775                 780                 


Ser Gln Ile Glu Val Lys Asp Val Thr Asp Thr Thr Ala Leu Ile Thr 
785                 790                 795                 800 


Trp Phe Lys Pro Leu Ala Glu Ile Asp Gly Ile Glu Leu Thr Tyr Gly 
                805                 810                 815     


Ile Lys Asp Val Pro Gly Asp Arg Thr Thr Ile Asp Leu Thr Glu Asp 
            820                 825                 830         


Glu Asn Gln Tyr Ser Ile Gly Asn Leu Lys Pro Asp Thr Glu Tyr Glu 
        835                 840                 845             


Val Ser Leu Ile Ser Arg Arg Gly Asp Met Ser Ser Asn Pro Ala Lys 
    850                 855                 860                 


Glu Thr Phe Thr Thr Gly Leu Asp Ala Pro Arg Asn Leu Arg Arg Val 
865                 870                 875                 880 


Ser Gln Thr Asp Asn Ser Ile Thr Leu Glu Trp Arg Asn Gly Lys Ala 
                885                 890                 895     


Ala Ile Asp Ser Tyr Arg Ile Lys Tyr Ala Pro Ile Ser Gly Gly Asp 
            900                 905                 910         


His Ala Glu Val Asp Val Pro Lys Ser Gln Gln Ala Thr Thr Lys Thr 
        915                 920                 925             


Thr Leu Thr Gly Leu Arg Pro Gly Thr Glu Tyr Gly Ile Gly Val Ser 
    930                 935                 940                 


Ala Val Lys Glu Asp Lys Glu Ser Asn Pro Ala Thr Ile Asn Ala Ala 
945                 950                 955                 960 


Thr Glu Leu Asp Thr Pro Lys Asp Leu Gln Val Ser Glu Thr Ala Glu 
                965                 970                 975     


Thr Ser Leu Thr Leu Leu Trp Lys Thr Pro Leu Ala Lys Phe Asp Arg 
            980                 985                 990         


Tyr Arg Leu Asn Tyr Ser Leu Pro  Thr Gly Gln Trp Val  Gly Val Gln 
        995                 1000                 1005             


Leu Pro  Arg Asn Thr Thr Ser  Tyr Val Leu Arg Gly  Leu Glu Pro 
    1010                 1015                 1020             


Gly Gln  Glu Tyr Asn Val Leu  Leu Thr Ala Glu Lys  Gly Arg His 
    1025                 1030                 1035             


Lys Ser  Lys Pro Ala Arg Val  Lys Ala Ser Thr Glu  Gln Ala Pro 
    1040                 1045                 1050             


Glu Leu  Glu Asn Leu Thr Val  Thr Glu Val Gly Trp  Asp Gly Leu 
    1055                 1060                 1065             


Arg Leu  Asn Trp Thr Ala Ala  Asp Gln Ala Tyr Glu  His Phe Ile 
    1070                 1075                 1080             


Ile Gln  Val Gln Glu Ala Asn  Lys Val Glu Ala Ala  Arg Asn Leu 
    1085                 1090                 1095             


Thr Val  Pro Gly Ser Leu Arg  Ala Val Asp Ile Pro  Gly Leu Lys 
    1100                 1105                 1110             


Ala Ala  Thr Pro Tyr Thr Val  Ser Ile Tyr Gly Val  Ile Gln Gly 
    1115                 1120                 1125             


Tyr Arg  Thr Pro Val Leu Ser  Ala Glu Ala Ser Thr  Gly Glu Thr 
    1130                 1135                 1140             


Pro Asn  Leu Gly Glu Val Val  Val Ala Glu Val Gly  Trp Asp Ala 
    1145                 1150                 1155             


Leu Lys  Leu Asn Trp Thr Ala  Pro Glu Gly Ala Tyr  Glu Tyr Phe 
    1160                 1165                 1170             


Phe Ile  Gln Val Gln Glu Ala  Asp Thr Val Glu Ala  Ala Gln Asn 
    1175                 1180                 1185             


Leu Thr  Val Pro Gly Gly Leu  Arg Ser Thr Asp Leu  Pro Gly Leu 
    1190                 1195                 1200             


Lys Ala  Ala Thr His Tyr Thr  Ile Thr Ile Arg Gly  Val Thr Gln 
    1205                 1210                 1215             


Asp Phe  Ser Thr Thr Pro Leu  Ser Val Glu Val Leu  Thr Glu Glu 
    1220                 1225                 1230             


Val Pro  Asp Met Gly Asn Leu  Thr Val Thr Glu Val  Ser Trp Asp 
    1235                 1240                 1245             


Ala Leu  Arg Leu Asn Trp Thr  Thr Pro Asp Gly Thr  Tyr Asp Gln 
    1250                 1255                 1260             


Phe Thr  Ile Gln Val Gln Glu  Ala Asp Gln Val Glu  Glu Ala His 
    1265                 1270                 1275             


Asn Leu  Thr Val Pro Gly Ser  Leu Arg Ser Met Glu  Ile Pro Gly 
    1280                 1285                 1290             


Leu Arg  Ala Gly Thr Pro Tyr  Thr Val Thr Leu His  Gly Glu Val 
    1295                 1300                 1305             


Arg Gly  His Ser Thr Arg Pro  Leu Ala Val Glu Val  Val Thr Glu 
    1310                 1315                 1320             


Asp Leu  Pro Gln Leu Gly Asp  Leu Ala Val Ser Glu  Val Gly Trp 
    1325                 1330                 1335             


Asp Gly  Leu Arg Leu Asn Trp  Thr Ala Ala Asp Asn  Ala Tyr Glu 
    1340                 1345                 1350             


His Phe  Val Ile Gln Val Gln  Glu Val Asn Lys Val  Glu Ala Ala 
    1355                 1360                 1365             


Gln Asn  Leu Thr Leu Pro Gly  Ser Leu Arg Ala Val  Asp Ile Pro 
    1370                 1375                 1380             


Gly Leu  Glu Ala Ala Thr Pro  Tyr Arg Val Ser Ile  Tyr Gly Val 
    1385                 1390                 1395             


Ile Arg  Gly Tyr Arg Thr Pro  Val Leu Ser Ala Glu  Ala Ser Thr 
    1400                 1405                 1410             


Ala Lys  Glu Pro Glu Ile Gly  Asn Leu Asn Val Ser  Asp Ile Thr 
    1415                 1420                 1425             


Pro Glu  Ser Phe Asn Leu Ser  Trp Met Ala Thr Asp  Gly Ile Phe 
    1430                 1435                 1440             


Glu Thr  Phe Thr Ile Glu Ile  Ile Asp Ser Asn Arg  Leu Leu Glu 
    1445                 1450                 1455             


Thr Val  Glu Tyr Asn Ile Ser  Gly Ala Glu Arg Thr  Ala His Ile 
    1460                 1465                 1470             


Ser Gly  Leu Pro Pro Ser Thr  Asp Phe Ile Val Tyr  Leu Ser Gly 
    1475                 1480                 1485             


Leu Ala  Pro Ser Ile Arg Thr  Lys Thr Ile Ser Ala  Thr Ala Thr 
    1490                 1495                 1500             


Thr Glu  Ala Leu Pro Leu Leu  Glu Asn Leu Thr Ile  Ser Asp Ile 
    1505                 1510                 1515             


Asn Pro  Tyr Gly Phe Thr Val  Ser Trp Met Ala Ser  Glu Asn Ala 
    1520                 1525                 1530             


Phe Asp  Ser Phe Leu Val Thr  Val Val Asp Ser Gly  Lys Leu Leu 
    1535                 1540                 1545             


Asp Pro  Gln Glu Phe Thr Leu  Ser Gly Thr Gln Arg  Lys Leu Glu 
    1550                 1555                 1560             


Leu Arg  Gly Leu Ile Thr Gly  Ile Gly Tyr Glu Val  Met Val Ser 
    1565                 1570                 1575             


Gly Phe  Thr Gln Gly His Gln  Thr Lys Pro Leu Arg  Ala Glu Ile 
    1580                 1585                 1590             


Val Thr  Glu Ala Glu Pro Glu  Val Asp Asn Leu Leu  Val Ser Asp 
    1595                 1600                 1605             


Ala Thr  Pro Asp Gly Phe Arg  Leu Ser Trp Thr Ala  Asp Glu Gly 
    1610                 1615                 1620             


Val Phe  Asp Asn Phe Val Leu  Lys Ile Arg Asp Thr  Lys Lys Gln 
    1625                 1630                 1635             


Ser Glu  Pro Leu Glu Ile Thr  Leu Leu Ala Pro Glu  Arg Thr Arg 
    1640                 1645                 1650             


Asp Ile  Thr Gly Leu Arg Glu  Ala Thr Glu Tyr Glu  Ile Glu Leu 
    1655                 1660                 1665             


Tyr Gly  Ile Ser Lys Gly Arg  Arg Ser Gln Thr Val  Ser Ala Ile 
    1670                 1675                 1680             


Ala Thr  Thr Ala Met Gly Ser  Pro Lys Glu Val Ile  Phe Ser Asp 
    1685                 1690                 1695             


Ile Thr  Glu Asn Ser Ala Thr  Val Ser Trp Arg Ala  Pro Thr Ala 
    1700                 1705                 1710             


Gln Val  Glu Ser Phe Arg Ile  Thr Tyr Val Pro Ile  Thr Gly Gly 
    1715                 1720                 1725             


Thr Pro  Ser Met Val Thr Val  Asp Gly Thr Lys Thr  Gln Thr Arg 
    1730                 1735                 1740             


Leu Val  Lys Leu Ile Pro Gly  Val Glu Tyr Leu Val  Ser Ile Ile 
    1745                 1750                 1755             


Ala Met  Lys Gly Phe Glu Glu  Ser Glu Pro Val Ser  Gly Ser Phe 
    1760                 1765                 1770             


Thr Thr  Ala Leu Asp Gly Pro  Ser Gly Leu Val Thr  Ala Asn Ile 
    1775                 1780                 1785             


Thr Asp  Ser Glu Ala Leu Ala  Arg Trp Gln Pro Ala  Ile Ala Thr 
    1790                 1795                 1800             


Val Asp  Ser Tyr Val Ile Ser  Tyr Thr Gly Glu Lys  Val Pro Glu 
    1805                 1810                 1815             


Ile Thr  Arg Thr Val Ser Gly  Asn Thr Val Glu Tyr  Ala Leu Thr 
    1820                 1825                 1830             


Asp Leu  Glu Pro Ala Thr Glu  Tyr Thr Leu Arg Ile  Phe Ala Glu 
    1835                 1840                 1845             


Lys Gly  Pro Gln Lys Ser Ser  Thr Ile Thr Ala Lys  Phe Thr Thr 
    1850                 1855                 1860             


Asp Leu  Asp Ser Pro Arg Asp  Leu Thr Ala Thr Glu  Val Gln Ser 
    1865                 1870                 1875             


Glu Thr  Ala Leu Leu Thr Trp  Arg Pro Pro Arg Ala  Ser Val Thr 
    1880                 1885                 1890             


Gly Tyr  Leu Leu Val Tyr Glu  Ser Val Asp Gly Thr  Val Lys Glu 
    1895                 1900                 1905             


Val Ile  Val Gly Pro Asp Thr  Thr Ser Tyr Ser Leu  Ala Asp Leu 
    1910                 1915                 1920             


Ser Pro  Ser Thr His Tyr Thr  Ala Lys Ile Gln Ala  Leu Asn Gly 
    1925                 1930                 1935             


Pro Leu  Arg Ser Asn Met Ile  Gln Thr Ile Phe Thr  Thr Ile Gly 
    1940                 1945                 1950             


Leu Leu  Tyr Pro Phe Pro Lys  Asp Cys Ser Gln Ala  Met Leu Asn 
    1955                 1960                 1965             


Gly Asp  Thr Thr Ser Gly Leu  Tyr Thr Ile Tyr Leu  Asn Gly Asp 
    1970                 1975                 1980             


Lys Ala  Glu Ala Leu Glu Val  Phe Cys Asp Met Thr  Ser Asp Gly 
    1985                 1990                 1995             


Gly Gly  Trp Ile Val Phe Leu  Arg Arg Lys Asn Gly  Arg Glu Asn 
    2000                 2005                 2010             


Phe Tyr  Gln Asn Trp Lys Ala  Tyr Ala Ala Gly Phe  Gly Asp Arg 
    2015                 2020                 2025             


Arg Glu  Glu Phe Trp Leu Gly  Leu Asp Asn Leu Asn  Lys Ile Thr 
    2030                 2035                 2040             


Ala Gln  Gly Gln Tyr Glu Leu  Arg Val Asp Leu Arg  Asp His Gly 
    2045                 2050                 2055             


Glu Thr  Ala Phe Ala Val Tyr  Asp Lys Phe Ser Val  Gly Asp Ala 
    2060                 2065                 2070             


Lys Thr  Arg Tyr Lys Leu Lys  Val Glu Gly Tyr Ser  Gly Thr Ala 
    2075                 2080                 2085             


Gly Asp  Ser Met Ala Tyr His  Asn Gly Arg Ser Phe  Ser Thr Phe 
    2090                 2095                 2100             


Asp Lys  Asp Thr Asp Ser Ala  Ile Thr Asn Cys Ala  Leu Ser Tyr 
    2105                 2110                 2115             


Lys Gly  Ala Phe Trp Tyr Arg  Asn Cys His Arg Val  Asn Leu Met 
    2120                 2125                 2130             


Gly Arg  Tyr Gly Asp Asn Asn  His Ser Gln Gly Val  Asn Trp Phe 
    2135                 2140                 2145             


His Trp  Lys Gly His Glu His  Ser Ile Gln Phe Ala  Glu Met Lys 
    2150                 2155                 2160             


Leu Arg  Pro Ser Asn Phe Arg  Asn Leu Glu Gly Arg  Arg Lys Arg 
    2165                 2170                 2175             


Ala 
    


