                         SEQUENCE LISTING

<110>  The General Hospital Corporation
       Brauns, Timothy
       Poznansky, Mark C.
       Gelfand, Jeffrey A.
       Chen, Hubiao
       McCormack, Stephen J.
 
<120>  ANTIGEN-BINDING FUSION PROTEINS WITH MODIFIED HSP70 DOMAINS

<130>  1417-3WO

<140>  PCT/US2017/021911
<141>  2017-03-10

<150>  US 62/306,168
<151>  2016-03-10

<160>  30    

<170>  PatentIn version 3.5

<210>  1
<211>  625
<212>  PRT
<213>  Mycobacterium tuberculosis

<400>  1

Met Ala Arg Ala Val Gly Ile Asp Leu Gly Thr Thr Asn Ser Val Val 
1               5                   10                  15      


Ser Val Leu Glu Gly Gly Asp Pro Val Val Val Ala Asn Ser Glu Gly 
            20                  25                  30          


Ser Arg Thr Thr Pro Ser Ile Val Ala Phe Ala Arg Asn Gly Glu Val 
        35                  40                  45              


Leu Val Gly Gln Pro Ala Lys Asn Gln Ala Val Thr Asn Val Asp Arg 
    50                  55                  60                  


Thr Val Arg Ser Val Lys Arg His Met Gly Ser Asp Trp Ser Ile Glu 
65                  70                  75                  80  


Ile Asp Gly Lys Lys Tyr Thr Ala Pro Glu Ile Ser Ala Arg Ile Leu 
                85                  90                  95      


Met Lys Leu Lys Arg Asp Ala Glu Ala Tyr Leu Gly Glu Asp Ile Thr 
            100                 105                 110         


Asp Ala Val Ile Thr Thr Pro Ala Tyr Phe Asn Asp Ala Gln Arg Gln 
        115                 120                 125             


Ala Thr Lys Asp Ala Gly Gln Ile Ala Gly Leu Asn Val Leu Arg Ile 
    130                 135                 140                 


Val Asn Glu Pro Thr Ala Ala Ala Leu Ala Tyr Gly Leu Asp Lys Gly 
145                 150                 155                 160 


Glu Lys Glu Gln Arg Ile Leu Val Phe Asp Leu Gly Gly Gly Thr Phe 
                165                 170                 175     


Asp Val Ser Leu Leu Glu Ile Gly Glu Gly Val Val Glu Val Arg Ala 
            180                 185                 190         


Thr Ser Gly Asp Asn His Leu Gly Gly Asp Asp Trp Asp Gln Arg Val 
        195                 200                 205             


Val Asp Trp Leu Val Asp Lys Phe Lys Gly Thr Ser Gly Ile Asp Leu 
    210                 215                 220                 


Thr Lys Asp Lys Met Ala Met Gln Arg Leu Arg Glu Ala Ala Glu Lys 
225                 230                 235                 240 


Ala Lys Ile Glu Leu Ser Ser Ser Gln Ser Thr Ser Ile Asn Leu Pro 
                245                 250                 255     


Tyr Ile Thr Val Asp Ala Asp Lys Asn Pro Leu Phe Leu Asp Glu Gln 
            260                 265                 270         


Leu Thr Arg Ala Glu Phe Gln Arg Ile Thr Gln Asp Leu Leu Asp Arg 
        275                 280                 285             


Thr Arg Lys Pro Phe Gln Ser Val Ile Ala Asp Thr Gly Ile Ser Val 
    290                 295                 300                 


Ser Glu Ile Asp His Val Val Leu Val Gly Gly Ser Thr Arg Met Pro 
305                 310                 315                 320 


Ala Val Thr Asp Leu Val Lys Glu Leu Thr Gly Gly Lys Glu Pro Asn 
                325                 330                 335     


Lys Gly Val Asn Pro Asp Glu Val Val Ala Val Gly Ala Ala Leu Gln 
            340                 345                 350         


Ala Gly Val Leu Lys Gly Glu Val Lys Asp Val Leu Leu Leu Asp Val 
        355                 360                 365             


Thr Pro Leu Ser Leu Gly Ile Glu Thr Lys Gly Gly Val Met Thr Arg 
    370                 375                 380                 


Leu Ile Glu Arg Asn Thr Thr Ile Pro Thr Lys Arg Ser Glu Thr Phe 
385                 390                 395                 400 


Thr Thr Ala Asp Asp Asn Gln Pro Ser Val Gln Ile Gln Val Tyr Gln 
                405                 410                 415     


Gly Glu Arg Glu Ile Ala Ala His Asn Lys Leu Leu Gly Ser Phe Glu 
            420                 425                 430         


Leu Thr Gly Ile Pro Pro Ala Pro Arg Gly Ile Pro Gln Ile Glu Val 
        435                 440                 445             


Thr Phe Asp Ile Asp Ala Asn Gly Ile Val His Val Thr Ala Lys Asp 
    450                 455                 460                 


Lys Gly Thr Gly Lys Glu Asn Thr Ile Arg Ile Gln Glu Gly Ser Gly 
465                 470                 475                 480 


Leu Ser Lys Glu Asp Ile Asp Arg Met Ile Lys Asp Ala Glu Ala His 
                485                 490                 495     


Ala Glu Glu Asp Arg Lys Arg Arg Glu Glu Ala Asp Val Arg Asn Gln 
            500                 505                 510         


Ala Glu Thr Leu Val Tyr Gln Thr Glu Lys Phe Val Lys Glu Gln Arg 
        515                 520                 525             


Glu Ala Glu Gly Gly Ser Lys Val Pro Glu Asp Thr Leu Asn Lys Val 
    530                 535                 540                 


Asp Ala Ala Val Ala Glu Ala Lys Ala Ala Leu Gly Gly Ser Asp Ile 
545                 550                 555                 560 


Ser Ala Ile Lys Ser Ala Met Glu Lys Leu Gly Gln Glu Ser Gln Ala 
                565                 570                 575     


Leu Gly Gln Ala Ile Tyr Glu Ala Ala Gln Ala Ala Ser Gln Ala Thr 
            580                 585                 590         


Gly Ala Ala His Pro Gly Gly Glu Pro Gly Gly Ala His Pro Gly Ser 
        595                 600                 605             


Ala Asp Asp Val Val Asp Ala Glu Val Val Asp Asp Gly Arg Glu Ala 
    610                 615                 620                 


Lys 
625 


<210>  2
<211>  1200
<212>  DNA
<213>  Artificial

<220>
<223>  encodes fusion protein

<400>  2
caagttcaac ttcaacaatc tggtcctggt cttgttactc cttctcaaac tctttctctt       60

acttgtgcta tttctggtga ttctgtttct tctaattctg ctacttggaa ttggattaga      120

caatctcctt ctagaggtct tgaatggctt ggtagaactt attatagatc taagtggtat      180

aatgattatg ctgtttctgt taagtctaga atgtctatta atcctgatac ttctaagaat      240

caattttctc ttcaacttaa ttctgttact cctgaagata ctgctgttta ttattgtgct      300

agaggtatga tgacttatta ttatggtatg gatgtttggg gtcaaggtac tactgttact      360

gtttcttctg gtattcttgg ttctggtgga ggtggatctg gtggaggtgg atcaggtgga      420

ggtggttctc aacctgttct tactcaatct tcttctcttt ctgcttctcc tggtgcttct      480

gcttctctta cttgtactct tagatctggt attaatgttg gtccttatag aatttattgg      540

tatcaacaaa agcctggttc tcctcctcaa tatcttctta attataagtc tgattctgat      600

aagcaacaag gttctggtgt tccttctaga ttttctggtt ctaaggatgc ttctgctaat      660

gctggtgttc ttcttatttc tggtcttaga tctgaagatg aagctgatta ttattgtatg      720

atttggcatt cttctgctgc tgtttttggt ggtggtactc aacttactgt tcttggtgga      780

ggtggatctg gtggaggtgg atcaggtgga ggtggttctg tgaccccttt gtctttgggt      840

attgaaacta aaggaggttt tatgactaga cttattgaac gtaataccac tattcctacg      900

aagagatcag agacatttac tactgctgat gacaatcaac ctagtgttca gatccaagtg      960

tatcaaggag agagggaaat tgctgcacat aataagttgc ttggctcatt tgaacttact     1020

ggaattccac ctgctcctag aggtattcca caaatagaag tgacatttga cattgacgca     1080

aatgggatag ttcatgtgac tgctaaggat aaaggaactg gtaaagagaa tactattcgt     1140

attcaggaag gtagtggact gtctaaggaa gatattgaca gaatgataaa ggacgcagaa     1200


<210>  3
<211>  401
<212>  PRT
<213>  Artificial

<220>
<223>  fusion protein

<400>  3

Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Thr Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser Val Ser Ser Asn 
            20                  25                  30          


Ser Ala Thr Trp Asn Trp Ile Arg Gln Ser Pro Ser Arg Gly Leu Glu 
        35                  40                  45              


Trp Leu Gly Arg Thr Tyr Tyr Arg Ser Lys Trp Tyr Asn Asp Tyr Ala 
    50                  55                  60                  


Val Ser Val Lys Ser Arg Met Ser Ile Asn Pro Asp Thr Ser Lys Asn 
65                  70                  75                  80  


Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Pro Glu Asp Thr Ala Val 
                85                  90                  95      


Tyr Tyr Cys Ala Arg Gly Met Met Thr Tyr Tyr Tyr Gly Met Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Ile Leu Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
    130                 135                 140                 


Pro Val Leu Thr Gln Ser Ser Ser Leu Ser Ala Ser Pro Gly Ala Ser 
145                 150                 155                 160 


Ala Ser Leu Thr Cys Thr Leu Arg Ser Gly Ile Asn Val Gly Pro Tyr 
                165                 170                 175     


Arg Ile Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Pro Pro Gln Tyr Leu 
            180                 185                 190         


Leu Asn Tyr Lys Ser Asp Ser Asp Lys Gln Gln Gly Ser Gly Val Pro 
        195                 200                 205             


Ser Arg Phe Ser Gly Ser Lys Asp Ala Ser Ala Asn Ala Gly Val Leu 
    210                 215                 220                 


Leu Ile Ser Gly Leu Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Met 
225                 230                 235                 240 


Ile Trp His Ser Ser Ala Ala Val Phe Gly Gly Gly Thr Gln Leu Thr 
                245                 250                 255     


Val Leu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            260                 265                 270         


Ser Val Thr Pro Leu Ser Leu Gly Ile Glu Thr Lys Gly Gly Phe Met 
        275                 280                 285             


Thr Arg Leu Ile Glu Arg Asn Thr Thr Ile Pro Thr Lys Arg Ser Glu 
    290                 295                 300                 


Thr Phe Thr Thr Ala Asp Asp Asn Gln Pro Ser Val Gln Ile Gln Val 
305                 310                 315                 320 


Tyr Gln Gly Glu Arg Glu Ile Ala Ala His Asn Lys Leu Leu Gly Ser 
                325                 330                 335     


Phe Glu Leu Thr Gly Ile Pro Pro Ala Pro Arg Gly Ile Pro Gln Ile 
            340                 345                 350         


Glu Val Thr Phe Asp Ile Asp Ala Asn Gly Ile Val His Val Thr Ala 
        355                 360                 365             


Lys Asp Lys Gly Thr Gly Lys Glu Asn Thr Ile Arg Ile Gln Glu Gly 
    370                 375                 380                 


Ser Gly Leu Ser Lys Glu Asp Ile Asp Arg Met Ile Lys Asp Ala Glu 
385                 390                 395                 400 


Ala 
    


<210>  4
<211>  1200
<212>  DNA
<213>  Artificial

<220>
<223>  encodes fusion protein

<400>  4
caagttcaac ttcaacaatc tggtcctggt cttgttactc cttctcaaac tctttctctt       60

acttgtgcta tttctggtga ttctgtttct tctaattctg ctacttggaa ttggattaga      120

caatctcctt ctagaggtct tgaatggctt ggtagaactt attatagatc taagtggtat      180

aatgattatg ctgtttctgt taagtctaga atgtctatta atcctgatac ttctaagaat      240

caattttctc ttcaacttaa ttctgttact cctgaagata ctgctgttta ttattgtgct      300

agaggtatga tgacttatta ttatggtatg gatgtttggg gtcaaggtac tactgttact      360

gtttcttctg gtattcttgg ttctggtgga ggtggatctg gtggaggtgg atcaggtgga      420

ggtggttctc aacctgttct tactcaatct tcttctcttt ctgcttctcc tggtgcttct      480

gcttctctta cttgtactct tagatctggt attaatgttg gtccttatag aatttattgg      540

tatcaacaaa agcctggttc tcctcctcaa tatcttctta attataagtc tgattctgat      600

aagcaacaag gttctggtgt tccttctaga ttttctggtt ctaaggatgc ttctgctaat      660

gctggtgttc ttcttatttc tggtcttaga tctgaagatg aagctgatta ttattgtatg      720

atttggcatt cttctgctgc tgtttttggt ggtggtactc aacttactgt tcttggtgga      780

ggtggatctg gtggaggtgg atcaggtgga ggtggttctg tgaccccttt gtctttgggt      840

attgaaacta aaggaggttt tatgactaga cttattgaac gtaataccac tattcctacg      900

aagagatcag agacatttac tactgctgat gacaatcaac ctagtgttca gatccaagtg      960

tatcaaggag agagggaaat tactaaggag aataatcttc ttggtagatt tgaattgtct     1020

ggtattccac ctgctcctag aggtattcca caaatagaag tgacatttga cattgacgca     1080

aatgggatag ttcatgtgac tgctaaggat aaaggaactg gtaaagagaa tactattcgt     1140

attcaggaag gtagtggact gtctaaggaa gatattgaca gaatgataaa ggacgcagaa     1200


<210>  5
<211>  401
<212>  PRT
<213>  Artificial

<220>
<223>  fusion protein

<400>  5

Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Thr Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser Val Ser Ser Asn 
            20                  25                  30          


Ser Ala Thr Trp Asn Trp Ile Arg Gln Ser Pro Ser Arg Gly Leu Glu 
        35                  40                  45              


Trp Leu Gly Arg Thr Tyr Tyr Arg Ser Lys Trp Tyr Asn Asp Tyr Ala 
    50                  55                  60                  


Val Ser Val Lys Ser Arg Met Ser Ile Asn Pro Asp Thr Ser Lys Asn 
65                  70                  75                  80  


Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Pro Glu Asp Thr Ala Val 
                85                  90                  95      


Tyr Tyr Cys Ala Arg Gly Met Met Thr Tyr Tyr Tyr Gly Met Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Ile Leu Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
    130                 135                 140                 


Pro Val Leu Thr Gln Ser Ser Ser Leu Ser Ala Ser Pro Gly Ala Ser 
145                 150                 155                 160 


Ala Ser Leu Thr Cys Thr Leu Arg Ser Gly Ile Asn Val Gly Pro Tyr 
                165                 170                 175     


Arg Ile Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Pro Pro Gln Tyr Leu 
            180                 185                 190         


Leu Asn Tyr Lys Ser Asp Ser Asp Lys Gln Gln Gly Ser Gly Val Pro 
        195                 200                 205             


Ser Arg Phe Ser Gly Ser Lys Asp Ala Ser Ala Asn Ala Gly Val Leu 
    210                 215                 220                 


Leu Ile Ser Gly Leu Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Met 
225                 230                 235                 240 


Ile Trp His Ser Ser Ala Ala Val Phe Gly Gly Gly Thr Gln Leu Thr 
                245                 250                 255     


Val Leu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            260                 265                 270         


Ser Val Thr Pro Leu Ser Leu Gly Ile Glu Thr Lys Gly Gly Phe Met 
        275                 280                 285             


Thr Arg Leu Ile Glu Arg Asn Thr Thr Ile Pro Thr Lys Arg Ser Glu 
    290                 295                 300                 


Thr Phe Thr Thr Ala Asp Asp Asn Gln Pro Ser Val Gln Ile Gln Val 
305                 310                 315                 320 


Tyr Gln Gly Glu Arg Glu Ile Thr Lys Glu Asn Asn Leu Leu Gly Arg 
                325                 330                 335     


Phe Glu Leu Ser Gly Ile Pro Pro Ala Pro Arg Gly Ile Pro Gln Ile 
            340                 345                 350         


Glu Val Thr Phe Asp Ile Asp Ala Asn Gly Ile Val His Val Thr Ala 
        355                 360                 365             


Lys Asp Lys Gly Thr Gly Lys Glu Asn Thr Ile Arg Ile Gln Glu Gly 
    370                 375                 380                 


Ser Gly Leu Ser Lys Glu Asp Ile Asp Arg Met Ile Lys Asp Ala Glu 
385                 390                 395                 400 


Ala 
    


<210>  6
<211>  1200
<212>  DNA
<213>  Artificial

<220>
<223>  encodes fusion protein

<400>  6
caagttcaac ttcaacaatc tggtcctggt cttgttactc cttctcaaac tctttctctt       60

acttgtgcta tttctggtga ttctgtttct tctaattctg ctacttggaa ttggattaga      120

caatctcctt ctagaggtct tgaatggctt ggtagaactt attatagatc taagtggtat      180

aatgattatg ctgtttctgt taagtctaga atgtctatta atcctgatac ttctaagaat      240

caattttctc ttcaacttaa ttctgttact cctgaagata ctgctgttta ttattgtgct      300

agaggtatga tgacttatta ttatggtatg gatgtttggg gtcaaggtac tactgttact      360

gtttcttctg gtattcttgg ttctggtgga ggtggatctg gtggaggtgg atcaggtgga      420

ggtggttctc aacctgttct tactcaatct tcttctcttt ctgcttctcc tggtgcttct      480

gcttctctta cttgtactct tagatctggt attaatgttg gtccttatag aatttattgg      540

tatcaacaaa agcctggttc tcctcctcaa tatcttctta attataagtc tgattctgat      600

aagcaacaag gttctggtgt tccttctaga ttttctggtt ctaaggatgc ttctgctaat      660

gctggtgttc ttcttatttc tggtcttaga tctgaagatg aagctgatta ttattgtatg      720

atttggcatt cttctgctgc tgtttttggt ggtggtactc aacttactgt tcttggtgga      780

ggtggatctg gtggaggtgg atcaggtgga ggtggttctg tgaccccttt gtctttgggt      840

attgaaacta aaggaggttt tatgactaga cttattgaac gtaataccac tattcctacg      900

aagagatcag agacatttac tactgctgat gacaatcaac ctagtgttca gatccaagtg      960

tatcaaggag agagggaaat tactaaggat aataatcttc ttggtagatt tgaactttct     1020

ggtattccac ctgctcctag aggtattcca caaatagaag tgacatttga cattgacgca     1080

aatgggatag ttcatgtgac tgctaaggat aaaggaactg gtaaagagaa tactattcgt     1140

attcaggaag gtagtggact gtctaaggaa gatattgaca gaatgataaa ggacgcagaa     1200


<210>  7
<211>  401
<212>  PRT
<213>  Artificial

<220>
<223>  fusion protein

<400>  7

Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Thr Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser Val Ser Ser Asn 
            20                  25                  30          


Ser Ala Thr Trp Asn Trp Ile Arg Gln Ser Pro Ser Arg Gly Leu Glu 
        35                  40                  45              


Trp Leu Gly Arg Thr Tyr Tyr Arg Ser Lys Trp Tyr Asn Asp Tyr Ala 
    50                  55                  60                  


Val Ser Val Lys Ser Arg Met Ser Ile Asn Pro Asp Thr Ser Lys Asn 
65                  70                  75                  80  


Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Pro Glu Asp Thr Ala Val 
                85                  90                  95      


Tyr Tyr Cys Ala Arg Gly Met Met Thr Tyr Tyr Tyr Gly Met Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Ile Leu Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
    130                 135                 140                 


Pro Val Leu Thr Gln Ser Ser Ser Leu Ser Ala Ser Pro Gly Ala Ser 
145                 150                 155                 160 


Ala Ser Leu Thr Cys Thr Leu Arg Ser Gly Ile Asn Val Gly Pro Tyr 
                165                 170                 175     


Arg Ile Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Pro Pro Gln Tyr Leu 
            180                 185                 190         


Leu Asn Tyr Lys Ser Asp Ser Asp Lys Gln Gln Gly Ser Gly Val Pro 
        195                 200                 205             


Ser Arg Phe Ser Gly Ser Lys Asp Ala Ser Ala Asn Ala Gly Val Leu 
    210                 215                 220                 


Leu Ile Ser Gly Leu Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Met 
225                 230                 235                 240 


Ile Trp His Ser Ser Ala Ala Val Phe Gly Gly Gly Thr Gln Leu Thr 
                245                 250                 255     


Val Leu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            260                 265                 270         


Ser Val Thr Pro Leu Ser Leu Gly Ile Glu Thr Lys Gly Gly Phe Met 
        275                 280                 285             


Thr Arg Leu Ile Glu Arg Asn Thr Thr Ile Pro Thr Lys Arg Ser Glu 
    290                 295                 300                 


Thr Phe Thr Thr Ala Asp Asp Asn Gln Pro Ser Val Gln Ile Gln Val 
305                 310                 315                 320 


Tyr Gln Gly Glu Arg Glu Ile Thr Lys Asp Asn Asn Leu Leu Gly Arg 
                325                 330                 335     


Phe Glu Leu Ser Gly Ile Pro Pro Ala Pro Arg Gly Ile Pro Gln Ile 
            340                 345                 350         


Glu Val Thr Phe Asp Ile Asp Ala Asn Gly Ile Val His Val Thr Ala 
        355                 360                 365             


Lys Asp Lys Gly Thr Gly Lys Glu Asn Thr Ile Arg Ile Gln Glu Gly 
    370                 375                 380                 


Ser Gly Leu Ser Lys Glu Asp Ile Asp Arg Met Ile Lys Asp Ala Glu 
385                 390                 395                 400 


Ala 
    


<210>  8
<211>  1209
<212>  DNA
<213>  Artificial

<220>
<223>  encodes fusion protein

<400>  8
caagttcaac ttcaacaatc tggtcctggt cttgttactc cttctcaaac tctttctctt       60

acttgtgcta tttctggtga ttctgtttct tctaattctg ctacttggaa ttggattaga      120

caatctcctt ctagaggtct tgaatggctt ggtagaactt attatagatc taagtggtat      180

aatgattatg ctgtttctgt taagtctaga atgtctatta atcctgatac ttctaagaat      240

caattttctc ttcaacttaa ttctgttact cctgaagata ctgctgttta ttattgtgct      300

agaggtatga tgacttatta ttatggtatg gatgtttggg gtcaaggtac tactgttact      360

gtttcttctg gtattcttgg ttctggtgga ggtggatctg gtggaggtgg atcaggtgga      420

ggtggttctc aacctgttct tactcaatct tcttctcttt ctgcttctcc tggtgcttct      480

gcttctctta cttgtactct tagatctggt attaatgttg gtccttatag aatttattgg      540

tatcaacaaa agcctggttc tcctcctcaa tatcttctta attataagtc tgattctgat      600

aagcaacaag gttctggtgt tccttctaga ttttctggtt ctaaggatgc ttctgctaat      660

gctggtgttc ttcttatttc tggtcttaga tctgaagatg aagctgatta ttattgtatg      720

atttggcatt cttctgctgc tgtttttggt ggtggtactc aacttactgt tcttggtgga      780

tcttcaagat cttcaagttc tggtggagga ggttctggtg gaggtggtgt gacccctttg      840

tctttgggta ttgaaactaa aggaggtttt atgactagac ttattgaacg taataccact      900

attcctacga agagatcaga gacatttact actgctgatg acaatcaacc tagtgttcag      960

atccaagtgt atcaaggaga gagggaaatt actaaggaga ataatcttct tggtagattt     1020

gaattgtctg gtattccacc tgctcctaga ggtattccac aaatagaagt gacatttgac     1080

attgacgcaa atgggatagt tcatgtgact gctaaggata aaggaactgg taaagagaat     1140

actattcgta ttcaggaagg tagtggactg tctaaggaag atattgacag aatgataaag     1200

gacgcagaa                                                             1209


<210>  9
<211>  404
<212>  PRT
<213>  Artificial

<220>
<223>  fusion protein

<400>  9

Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Thr Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser Val Ser Ser Asn 
            20                  25                  30          


Ser Ala Thr Trp Asn Trp Ile Arg Gln Ser Pro Ser Arg Gly Leu Glu 
        35                  40                  45              


Trp Leu Gly Arg Thr Tyr Tyr Arg Ser Lys Trp Tyr Asn Asp Tyr Ala 
    50                  55                  60                  


Val Ser Val Lys Ser Arg Met Ser Ile Asn Pro Asp Thr Ser Lys Asn 
65                  70                  75                  80  


Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Pro Glu Asp Thr Ala Val 
                85                  90                  95      


Tyr Tyr Cys Ala Arg Gly Met Met Thr Tyr Tyr Tyr Gly Met Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Ile Leu Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
    130                 135                 140                 


Pro Val Leu Thr Gln Ser Ser Ser Leu Ser Ala Ser Pro Gly Ala Ser 
145                 150                 155                 160 


Ala Ser Leu Thr Cys Thr Leu Arg Ser Gly Ile Asn Val Gly Pro Tyr 
                165                 170                 175     


Arg Ile Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Pro Pro Gln Tyr Leu 
            180                 185                 190         


Leu Asn Tyr Lys Ser Asp Ser Asp Lys Gln Gln Gly Ser Gly Val Pro 
        195                 200                 205             


Ser Arg Phe Ser Gly Ser Lys Asp Ala Ser Ala Asn Ala Gly Val Leu 
    210                 215                 220                 


Leu Ile Ser Gly Leu Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Met 
225                 230                 235                 240 


Ile Trp His Ser Ser Ala Ala Val Phe Gly Gly Gly Thr Gln Leu Thr 
                245                 250                 255     


Val Leu Gly Gly Ser Ser Arg Ser Ser Ser Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Gly Gly Gly Gly Val Thr Pro Leu Ser Leu Gly Ile Glu Thr Lys Gly 
        275                 280                 285             


Gly Phe Met Thr Arg Leu Ile Glu Arg Asn Thr Thr Ile Pro Thr Lys 
    290                 295                 300                 


Arg Ser Glu Thr Phe Thr Thr Ala Asp Asp Asn Gln Pro Ser Val Gln 
305                 310                 315                 320 


Ile Gln Val Tyr Gln Gly Glu Arg Glu Ile Thr Lys Glu Asn Asn Leu 
                325                 330                 335     


Leu Gly Arg Phe Glu Leu Ser Gly Ile Pro Pro Ala Pro Arg Gly Ile 
            340                 345                 350         


Pro Gln Ile Glu Val Thr Phe Asp Ile Asp Ala Asn Gly Ile Val His 
        355                 360                 365             


Val Thr Ala Lys Asp Lys Gly Thr Gly Lys Glu Asn Thr Ile Arg Ile 
    370                 375                 380                 


Gln Glu Gly Ser Gly Leu Ser Lys Glu Asp Ile Asp Arg Met Ile Lys 
385                 390                 395                 400 


Asp Ala Glu Ala 
                


<210>  10
<211>  1209
<212>  DNA
<213>  Artificial

<220>
<223>  encodes fusion protein

<400>  10
caagttcaac ttcaacaatc tggtcctggt cttgttactc cttctcaaac tctttctctt       60

acttgtgcta tttctggtga ttctgtttct tctaattctg ctacttggaa ttggattaga      120

caatctcctt ctagaggtct tgaatggctt ggtagaactt attatagatc taagtggtat      180

aatgattatg ctgtttctgt taagtctaga atgtctatta atcctgatac ttctaagaat      240

caattttctc ttcaacttaa ttctgttact cctgaagata ctgctgttta ttattgtgct      300

agaggtatga tgacttatta ttatggtatg gatgtttggg gtcaaggtac tactgttact      360

gtttcttctg gtattcttgg ttctggtgga ggtggatctg gtggaggtgg atcaggtgga      420

ggtggttctc aacctgttct tactcaatct tcttctcttt ctgcttctcc tggtgcttct      480

gcttctctta cttgtactct tagatctggt attaatgttg gtccttatag aatttattgg      540

tatcaacaaa agcctggttc tcctcctcaa tatcttctta attataagtc tgattctgat      600

aagcaacaag gttctggtgt tccttctaga ttttctggtt ctaaggatgc ttctgctaat      660

gctggtgttc ttcttatttc tggtcttaga tctgaagatg aagctgatta ttattgtatg      720

atttggcatt cttctgctgc tgtttttggt ggtggtactc aacttactgt tcttggtgga      780

tcttcagaat cttcaagttc tggtggagga ggttctggtg gaggtggtgt gacccctttg      840

tctttgggta ttgaaactaa aggaggtttt atgactagac ttattgaacg taataccact      900

attcctacga agagatcaga gacatttact actgctgatg acaatcaacc tagtgttcag      960

atccaagtgt atcaaggaga gagggaaatt actaaggaga ataatcttct tggtagattt     1020

gaattgtctg gtattccacc tgctcctaga ggtattccac aaatagaagt gacatttgac     1080

attgacgcaa atgggatagt tcatgtgact gctaaggata aaggaactgg taaagagaat     1140

actattcgta ttcaggaagg tagtggactg tctaaggaag atattgacag aatgataaag     1200

gacgcagaa                                                             1209


<210>  11
<211>  404
<212>  PRT
<213>  Artificial

<220>
<223>  fusion protein

<400>  11

Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Thr Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser Val Ser Ser Asn 
            20                  25                  30          


Ser Ala Thr Trp Asn Trp Ile Arg Gln Ser Pro Ser Arg Gly Leu Glu 
        35                  40                  45              


Trp Leu Gly Arg Thr Tyr Tyr Arg Ser Lys Trp Tyr Asn Asp Tyr Ala 
    50                  55                  60                  


Val Ser Val Lys Ser Arg Met Ser Ile Asn Pro Asp Thr Ser Lys Asn 
65                  70                  75                  80  


Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Pro Glu Asp Thr Ala Val 
                85                  90                  95      


Tyr Tyr Cys Ala Arg Gly Met Met Thr Tyr Tyr Tyr Gly Met Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Ile Leu Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
    130                 135                 140                 


Pro Val Leu Thr Gln Ser Ser Ser Leu Ser Ala Ser Pro Gly Ala Ser 
145                 150                 155                 160 


Ala Ser Leu Thr Cys Thr Leu Arg Ser Gly Ile Asn Val Gly Pro Tyr 
                165                 170                 175     


Arg Ile Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Pro Pro Gln Tyr Leu 
            180                 185                 190         


Leu Asn Tyr Lys Ser Asp Ser Asp Lys Gln Gln Gly Ser Gly Val Pro 
        195                 200                 205             


Ser Arg Phe Ser Gly Ser Lys Asp Ala Ser Ala Asn Ala Gly Val Leu 
    210                 215                 220                 


Leu Ile Ser Gly Leu Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Met 
225                 230                 235                 240 


Ile Trp His Ser Ser Ala Ala Val Phe Gly Gly Gly Thr Gln Leu Thr 
                245                 250                 255     


Val Leu Gly Gly Ser Ser Glu Ser Ser Ser Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Gly Gly Gly Gly Val Thr Pro Leu Ser Leu Gly Ile Glu Thr Lys Gly 
        275                 280                 285             


Gly Phe Met Thr Arg Leu Ile Glu Arg Asn Thr Thr Ile Pro Thr Lys 
    290                 295                 300                 


Arg Ser Glu Thr Phe Thr Thr Ala Asp Asp Asn Gln Pro Ser Val Gln 
305                 310                 315                 320 


Ile Gln Val Tyr Gln Gly Glu Arg Glu Ile Thr Lys Glu Asn Asn Leu 
                325                 330                 335     


Leu Gly Arg Phe Glu Leu Ser Gly Ile Pro Pro Ala Pro Arg Gly Ile 
            340                 345                 350         


Pro Gln Ile Glu Val Thr Phe Asp Ile Asp Ala Asn Gly Ile Val His 
        355                 360                 365             


Val Thr Ala Lys Asp Lys Gly Thr Gly Lys Glu Asn Thr Ile Arg Ile 
    370                 375                 380                 


Gln Glu Gly Ser Gly Leu Ser Lys Glu Asp Ile Asp Arg Met Ile Lys 
385                 390                 395                 400 


Asp Ala Glu Ala 
                


<210>  12
<211>  771
<212>  PRT
<213>  Artificial

<220>
<223>  fusion protein

<400>  12

Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Thr Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser Val Ser Ser Asn 
            20                  25                  30          


Ser Ala Thr Trp Asn Trp Ile Arg Gln Ser Pro Ser Arg Gly Leu Glu 
        35                  40                  45              


Trp Leu Gly Arg Thr Tyr Tyr Arg Ser Lys Trp Tyr Asn Asp Tyr Ala 
    50                  55                  60                  


Val Ser Val Lys Ser Arg Met Ser Ile Asn Pro Asp Thr Ser Lys Asn 
65                  70                  75                  80  


Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Pro Glu Asp Thr Ala Val 
                85                  90                  95      


Tyr Tyr Cys Ala Arg Gly Met Met Thr Tyr Tyr Tyr Gly Met Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Ile Leu Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
    130                 135                 140                 


Pro Val Leu Thr Gln Ser Ser Ser Leu Ser Ala Ser Pro Gly Ala Ser 
145                 150                 155                 160 


Ala Ser Leu Thr Cys Thr Leu Arg Ser Gly Ile Asn Val Gly Pro Tyr 
                165                 170                 175     


Arg Ile Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Pro Pro Gln Tyr Leu 
            180                 185                 190         


Leu Asn Tyr Lys Ser Asp Ser Asp Lys Gln Gln Gly Ser Gly Val Pro 
        195                 200                 205             


Ser Arg Phe Ser Gly Ser Lys Asp Ala Ser Ala Asn Ala Gly Val Leu 
    210                 215                 220                 


Leu Ile Ser Gly Leu Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Met 
225                 230                 235                 240 


Ile Trp His Ser Ser Ala Ala Val Phe Gly Gly Gly Thr Gln Leu Thr 
                245                 250                 255     


Val Leu Gly Gly Ser Ser Arg Ser Ser Ser Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Gly Gly Gly Gly Met Ala Arg Ala Val Gly Ile Asp Leu Gly Thr Thr 
        275                 280                 285             


Asn Ser Val Val Ser Val Leu Glu Gly Gly Asp Pro Val Val Val Ala 
    290                 295                 300                 


Asn Ser Glu Gly Ser Arg Thr Thr Pro Ser Ile Val Ala Phe Ala Arg 
305                 310                 315                 320 


Asn Gly Glu Val Leu Val Gly Gln Pro Ala Lys Asn Gln Ala Val Thr 
                325                 330                 335     


Asn Val Asp Arg Thr Val Arg Ser Val Lys Arg His Met Gly Ser Asp 
            340                 345                 350         


Trp Ser Ile Glu Ile Asp Gly Lys Lys Tyr Thr Ala Pro Glu Ile Ser 
        355                 360                 365             


Ala Arg Ile Leu Met Lys Leu Lys Arg Asp Ala Glu Ala Tyr Leu Gly 
    370                 375                 380                 


Glu Asp Ile Thr Asp Ala Val Ile Thr Thr Pro Ala Tyr Phe Asn Asp 
385                 390                 395                 400 


Ala Gln Arg Gln Ala Thr Lys Asp Ala Gly Gln Ile Ala Gly Leu Asn 
                405                 410                 415     


Val Leu Arg Ile Val Asn Glu Pro Thr Ala Ala Ala Leu Ala Tyr Gly 
            420                 425                 430         


Leu Asp Lys Gly Glu Lys Glu Gln Arg Ile Leu Val Phe Asp Leu Gly 
        435                 440                 445             


Gly Gly Thr Phe Asp Val Ser Leu Leu Glu Ile Gly Glu Gly Val Val 
    450                 455                 460                 


Glu Val Arg Ala Thr Ser Gly Asp Asn His Leu Gly Gly Asp Asp Trp 
465                 470                 475                 480 


Asp Gln Arg Val Val Asp Trp Leu Val Asp Lys Phe Lys Gly Thr Ser 
                485                 490                 495     


Gly Ile Asp Leu Thr Lys Asp Lys Met Ala Met Gln Arg Leu Arg Glu 
            500                 505                 510         


Ala Ala Glu Lys Ala Lys Ile Glu Leu Ser Ser Ser Gln Ser Thr Ser 
        515                 520                 525             


Ile Asn Leu Pro Tyr Ile Thr Val Asp Ala Asp Lys Asn Pro Leu Phe 
    530                 535                 540                 


Leu Asp Glu Gln Leu Thr Arg Ala Glu Phe Gln Arg Ile Thr Gln Asp 
545                 550                 555                 560 


Leu Leu Asp Arg Thr Arg Lys Pro Phe Gln Ser Val Ile Ala Asp Thr 
                565                 570                 575     


Gly Ile Ser Val Ser Glu Ile Asp His Val Val Leu Val Gly Gly Ser 
            580                 585                 590         


Thr Ala Met Pro Ala Val Thr Asp Leu Val Lys Glu Leu Thr Gly Gly 
        595                 600                 605             


Lys Glu Pro Asn Lys Gly Val Asn Pro Asp Glu Val Val Ala Val Gly 
    610                 615                 620                 


Ala Ala Leu Gln Ala Gly Val Leu Lys Gly Glu Val Lys Asp Val Leu 
625                 630                 635                 640 


Leu Leu Asp Val Thr Pro Leu Ser Leu Gly Ile Glu Thr Lys Gly Gly 
                645                 650                 655     


Phe Met Thr Arg Leu Ile Glu Arg Asn Thr Thr Ile Pro Thr Lys Arg 
            660                 665                 670         


Ser Glu Thr Phe Thr Thr Ala Asp Asp Asn Gln Pro Ser Val Gln Ile 
        675                 680                 685             


Gln Val Tyr Gln Gly Glu Arg Glu Ile Thr Lys Glu Asn Asn Leu Leu 
    690                 695                 700                 


Gly Arg Phe Glu Leu Ser Gly Ile Pro Pro Ala Pro Arg Gly Ile Pro 
705                 710                 715                 720 


Gln Ile Glu Val Thr Phe Asp Ile Asp Ala Asn Gly Ile Val His Val 
                725                 730                 735     


Thr Ala Lys Asp Lys Gly Thr Gly Lys Glu Asn Thr Ile Arg Ile Gln 
            740                 745                 750         


Glu Gly Ser Gly Leu Ser Lys Glu Asp Ile Asp Arg Met Ile Lys Asp 
        755                 760                 765             


Ala Glu Ala 
    770     


<210>  13
<211>  771
<212>  PRT
<213>  Artificial

<220>
<223>  fusion protein

<400>  13

Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Thr Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser Val Ser Ser Asn 
            20                  25                  30          


Ser Ala Thr Trp Asn Trp Ile Arg Gln Ser Pro Ser Arg Gly Leu Glu 
        35                  40                  45              


Trp Leu Gly Arg Thr Tyr Tyr Arg Ser Lys Trp Tyr Asn Asp Tyr Ala 
    50                  55                  60                  


Val Ser Val Lys Ser Arg Met Ser Ile Asn Pro Asp Thr Ser Lys Asn 
65                  70                  75                  80  


Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Pro Glu Asp Thr Ala Val 
                85                  90                  95      


Tyr Tyr Cys Ala Arg Gly Met Met Thr Tyr Tyr Tyr Gly Met Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Ile Leu Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
    130                 135                 140                 


Pro Val Leu Thr Gln Ser Ser Ser Leu Ser Ala Ser Pro Gly Ala Ser 
145                 150                 155                 160 


Ala Ser Leu Thr Cys Thr Leu Arg Ser Gly Ile Asn Val Gly Pro Tyr 
                165                 170                 175     


Arg Ile Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Pro Pro Gln Tyr Leu 
            180                 185                 190         


Leu Asn Tyr Lys Ser Asp Ser Asp Lys Gln Gln Gly Ser Gly Val Pro 
        195                 200                 205             


Ser Arg Phe Ser Gly Ser Lys Asp Ala Ser Ala Asn Ala Gly Val Leu 
    210                 215                 220                 


Leu Ile Ser Gly Leu Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Met 
225                 230                 235                 240 


Ile Trp His Ser Ser Ala Ala Val Phe Gly Gly Gly Thr Gln Leu Thr 
                245                 250                 255     


Val Leu Gly Gly Ser Ser Glu Ser Ser Ser Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Gly Gly Gly Gly Met Ala Arg Ala Val Gly Ile Asp Leu Gly Thr Thr 
        275                 280                 285             


Asn Ser Val Val Ser Val Leu Glu Gly Gly Asp Pro Val Val Val Ala 
    290                 295                 300                 


Asn Ser Glu Gly Ser Arg Thr Thr Pro Ser Ile Val Ala Phe Ala Arg 
305                 310                 315                 320 


Asn Gly Glu Val Leu Val Gly Gln Pro Ala Lys Asn Gln Ala Val Thr 
                325                 330                 335     


Asn Val Asp Arg Thr Val Arg Ser Val Lys Arg His Met Gly Ser Asp 
            340                 345                 350         


Trp Ser Ile Glu Ile Asp Gly Lys Lys Tyr Thr Ala Pro Glu Ile Ser 
        355                 360                 365             


Ala Arg Ile Leu Met Lys Leu Lys Arg Asp Ala Glu Ala Tyr Leu Gly 
    370                 375                 380                 


Glu Asp Ile Thr Asp Ala Val Ile Thr Thr Pro Ala Tyr Phe Asn Asp 
385                 390                 395                 400 


Ala Gln Arg Gln Ala Thr Lys Asp Ala Gly Gln Ile Ala Gly Leu Asn 
                405                 410                 415     


Val Leu Arg Ile Val Asn Glu Pro Thr Ala Ala Ala Leu Ala Tyr Gly 
            420                 425                 430         


Leu Asp Lys Gly Glu Lys Glu Gln Arg Ile Leu Val Phe Asp Leu Gly 
        435                 440                 445             


Gly Gly Thr Phe Asp Val Ser Leu Leu Glu Ile Gly Glu Gly Val Val 
    450                 455                 460                 


Glu Val Arg Ala Thr Ser Gly Asp Asn His Leu Gly Gly Asp Asp Trp 
465                 470                 475                 480 


Asp Gln Arg Val Val Asp Trp Leu Val Asp Lys Phe Lys Gly Thr Ser 
                485                 490                 495     


Gly Ile Asp Leu Thr Lys Asp Lys Met Ala Met Gln Arg Leu Arg Glu 
            500                 505                 510         


Ala Ala Glu Lys Ala Lys Ile Glu Leu Ser Ser Ser Gln Ser Thr Ser 
        515                 520                 525             


Ile Asn Leu Pro Tyr Ile Thr Val Asp Ala Asp Lys Asn Pro Leu Phe 
    530                 535                 540                 


Leu Asp Glu Gln Leu Thr Arg Ala Glu Phe Gln Arg Ile Thr Gln Asp 
545                 550                 555                 560 


Leu Leu Asp Arg Thr Arg Lys Pro Phe Gln Ser Val Ile Ala Asp Thr 
                565                 570                 575     


Gly Ile Ser Val Ser Glu Ile Asp His Val Val Leu Val Gly Gly Ser 
            580                 585                 590         


Thr Ala Met Pro Ala Val Thr Asp Leu Val Lys Glu Leu Thr Gly Gly 
        595                 600                 605             


Lys Glu Pro Asn Lys Gly Val Asn Pro Asp Glu Val Val Ala Val Gly 
    610                 615                 620                 


Ala Ala Leu Gln Ala Gly Val Leu Lys Gly Glu Val Lys Asp Val Leu 
625                 630                 635                 640 


Leu Leu Asp Val Thr Pro Leu Ser Leu Gly Ile Glu Thr Lys Gly Gly 
                645                 650                 655     


Phe Met Thr Arg Leu Ile Glu Arg Asn Thr Thr Ile Pro Thr Lys Arg 
            660                 665                 670         


Ser Glu Thr Phe Thr Thr Ala Asp Asp Asn Gln Pro Ser Val Gln Ile 
        675                 680                 685             


Gln Val Tyr Gln Gly Glu Arg Glu Ile Thr Lys Glu Asn Asn Leu Leu 
    690                 695                 700                 


Gly Arg Phe Glu Leu Ser Gly Ile Pro Pro Ala Pro Arg Gly Ile Pro 
705                 710                 715                 720 


Gln Ile Glu Val Thr Phe Asp Ile Asp Ala Asn Gly Ile Val His Val 
                725                 730                 735     


Thr Ala Lys Asp Lys Gly Thr Gly Lys Glu Asn Thr Ile Arg Ile Gln 
            740                 745                 750         


Glu Gly Ser Gly Leu Ser Lys Glu Asp Ile Asp Arg Met Ile Lys Asp 
        755                 760                 765             


Ala Glu Ala 
    770     


<210>  14
<211>  4
<212>  PRT
<213>  Mycobacterium tuberculosis

<400>  14

Lys Asp Glu Leu 
1               


<210>  15
<211>  14
<212>  PRT
<213>  Mycobacterium tuberculosis

<400>  15

Ala Ala His Asn Lys Leu Leu Gly Ser Phe Glu Leu Thr Gly 
1               5                   10                  


<210>  16
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  modified CD94 domain

<400>  16

Ala Ala His Asn Asn Leu Leu Gly Ser Phe Glu Leu Thr Gly 
1               5                   10                  


<210>  17
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  modified CD94 domain

<400>  17

Ala Ala His Asn Asn Leu Leu Gly Arg Phe Glu Leu Thr Gly 
1               5                   10                  


<210>  18
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  modified CD94 domain

<400>  18

Ala Ala His Asn Asn Leu Leu Gly Arg Phe Glu Leu Ser Gly 
1               5                   10                  


<210>  19
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  modified CD94 domain

<400>  19

Thr Lys Glu Asn Asn Leu Leu Gly Arg Phe Glu Leu Ser Gly 
1               5                   10                  


<210>  20
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  modified CD94 domain

<400>  20

Thr Arg Asp Asn Asn Leu Leu Gly Arg Phe Glu Leu Ser Gly 
1               5                   10                  


<210>  21
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  linker

<400>  21

Gly Gly Ser Ser Arg Ser Ser 
1               5           


<210>  22
<211>  28
<212>  PRT
<213>  Artificial

<220>
<223>  linker

<400>  22

Gly Gly Gly Ser Gly Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly 
1               5                   10                  15      


Gly Ser Gly Gly Gly Gly Gly Gly Ser Gly Gly Gly 
            20                  25              


<210>  23
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  linker

<400>  23

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  24
<211>  18
<212>  PRT
<213>  Artificial

<220>
<223>  linker

<400>  24

Gly Gly Ser Ser Arg Ser Ser Ser Ser Gly Gly Gly Gly Ser Gly Gly 
1               5                   10                  15      


Gly Gly 
        


<210>  25
<211>  18
<212>  PRT
<213>  Artificial

<220>
<223>  linker

<400>  25

Gly Gly Ser Ser Glu Ser Ser Ser Ser Gly Gly Gly Gly Ser Gly Gly 
1               5                   10                  15      


Gly Gly 
        


<210>  26
<211>  625
<212>  PRT
<213>  Artificial

<220>
<223>  fusion protein

<400>  26

Met Ala Arg Ala Val Gly Ile Asp Leu Gly Thr Thr Asn Ser Val Val 
1               5                   10                  15      


Ser Val Leu Glu Gly Gly Asp Pro Val Val Val Ala Asn Ser Glu Gly 
            20                  25                  30          


Ser Arg Thr Thr Pro Ser Ile Val Ala Phe Ala Arg Asn Gly Glu Val 
        35                  40                  45              


Leu Val Gly Gln Pro Ala Lys Asn Gln Ala Val Thr Asn Val Asp Arg 
    50                  55                  60                  


Thr Val Arg Ser Val Lys Arg His Met Gly Ser Asp Trp Ser Ile Glu 
65                  70                  75                  80  


Ile Asp Gly Lys Lys Tyr Thr Ala Pro Glu Ile Ser Ala Arg Ile Leu 
                85                  90                  95      


Met Lys Leu Lys Arg Asp Ala Glu Ala Tyr Leu Gly Glu Asp Ile Thr 
            100                 105                 110         


Asp Ala Val Ile Thr Thr Pro Ala Tyr Phe Asn Asp Ala Gln Arg Gln 
        115                 120                 125             


Ala Thr Lys Asp Ala Gly Gln Ile Ala Gly Leu Asn Val Leu Arg Ile 
    130                 135                 140                 


Val Asn Glu Pro Thr Ala Ala Ala Leu Ala Tyr Gly Leu Asp Lys Gly 
145                 150                 155                 160 


Glu Lys Glu Gln Arg Ile Leu Val Phe Asp Leu Gly Gly Gly Thr Phe 
                165                 170                 175     


Asp Val Ser Leu Leu Glu Ile Gly Glu Gly Val Val Glu Val Arg Ala 
            180                 185                 190         


Thr Ser Gly Asp Asn His Leu Gly Gly Asp Asp Trp Asp Gln Arg Val 
        195                 200                 205             


Val Asp Trp Leu Val Asp Lys Phe Lys Gly Thr Ser Gly Ile Asp Leu 
    210                 215                 220                 


Thr Lys Asp Lys Met Ala Met Gln Arg Leu Arg Glu Ala Ala Glu Lys 
225                 230                 235                 240 


Ala Lys Ile Glu Leu Ser Ser Ser Gln Ser Thr Ser Ile Asn Leu Pro 
                245                 250                 255     


Tyr Ile Thr Val Asp Ala Asp Lys Asn Pro Leu Phe Leu Asp Glu Gln 
            260                 265                 270         


Leu Thr Arg Ala Glu Phe Gln Arg Ile Thr Gln Asp Leu Leu Asp Arg 
        275                 280                 285             


Thr Arg Lys Pro Phe Gln Ser Val Ile Ala Asp Thr Gly Ile Ser Val 
    290                 295                 300                 


Ser Glu Ile Asp His Val Val Leu Val Gly Gly Ser Thr Arg Met Pro 
305                 310                 315                 320 


Ala Val Thr Asp Leu Val Lys Glu Leu Thr Gly Gly Lys Glu Pro Asn 
                325                 330                 335     


Lys Gly Val Asn Pro Asp Glu Val Val Ala Val Gly Ala Ala Leu Gln 
            340                 345                 350         


Ala Gly Val Leu Lys Gly Glu Val Lys Asp Val Leu Leu Leu Asp Val 
        355                 360                 365             


Thr Pro Leu Ser Leu Gly Ile Glu Thr Lys Gly Gly Phe Met Thr Arg 
    370                 375                 380                 


Leu Ile Glu Arg Asn Thr Thr Ile Pro Thr Lys Arg Ser Glu Thr Phe 
385                 390                 395                 400 


Thr Thr Ala Asp Asp Asn Gln Pro Ser Val Gln Ile Gln Val Tyr Gln 
                405                 410                 415     


Gly Glu Arg Glu Ile Ala Ala His Asn Lys Leu Leu Gly Ser Phe Glu 
            420                 425                 430         


Leu Thr Gly Ile Pro Pro Ala Pro Arg Gly Ile Pro Gln Ile Glu Val 
        435                 440                 445             


Thr Phe Asp Ile Asp Ala Asn Gly Ile Val His Val Thr Ala Lys Asp 
    450                 455                 460                 


Lys Gly Thr Gly Lys Glu Asn Thr Ile Arg Ile Gln Glu Gly Ser Gly 
465                 470                 475                 480 


Leu Ser Lys Glu Asp Ile Asp Arg Met Ile Lys Asp Ala Glu Ala His 
                485                 490                 495     


Ala Glu Glu Asp Arg Lys Arg Arg Glu Glu Ala Asp Val Arg Asn Gln 
            500                 505                 510         


Ala Glu Thr Leu Val Tyr Gln Thr Glu Lys Phe Val Lys Glu Gln Arg 
        515                 520                 525             


Glu Ala Glu Gly Gly Ser Lys Val Pro Glu Asp Thr Leu Asn Lys Val 
    530                 535                 540                 


Asp Ala Ala Val Ala Glu Ala Lys Ala Ala Leu Gly Gly Ser Asp Ile 
545                 550                 555                 560 


Ser Ala Ile Lys Ser Ala Met Glu Lys Leu Gly Gln Glu Ser Gln Ala 
                565                 570                 575     


Leu Gly Gln Ala Ile Tyr Glu Ala Ala Gln Ala Ala Ser Gln Ala Thr 
            580                 585                 590         


Gly Ala Ala His Pro Gly Gly Glu Pro Gly Gly Ala His Pro Gly Ser 
        595                 600                 605             


Ala Asp Asp Val Val Asp Ala Glu Val Val Asp Asp Gly Arg Glu Ala 
    610                 615                 620                 


Lys 
625 


<210>  27
<211>  898
<212>  PRT
<213>  Artificial

<220>
<223>  fusion protein

<400>  27

Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Thr Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser Val Ser Ser Asn 
            20                  25                  30          


Ser Ala Thr Trp Asn Trp Ile Arg Gln Ser Pro Ser Arg Gly Leu Glu 
        35                  40                  45              


Trp Leu Gly Arg Thr Tyr Tyr Arg Ser Lys Trp Tyr Asn Asp Tyr Ala 
    50                  55                  60                  


Val Ser Val Lys Ser Arg Met Ser Ile Asn Pro Asp Thr Ser Lys Asn 
65                  70                  75                  80  


Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Pro Glu Asp Thr Ala Val 
                85                  90                  95      


Tyr Tyr Cys Ala Arg Gly Met Met Thr Tyr Tyr Tyr Gly Met Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Ile Leu Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
    130                 135                 140                 


Pro Val Leu Thr Gln Ser Ser Ser Leu Ser Ala Ser Pro Gly Ala Ser 
145                 150                 155                 160 


Ala Ser Leu Thr Cys Thr Leu Arg Ser Gly Ile Asn Val Gly Pro Tyr 
                165                 170                 175     


Arg Ile Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Pro Pro Gln Tyr Leu 
            180                 185                 190         


Leu Asn Tyr Lys Ser Asp Ser Asp Lys Gln Gln Gly Ser Gly Val Pro 
        195                 200                 205             


Ser Arg Phe Ser Gly Ser Lys Asp Ala Ser Ala Asn Ala Gly Val Leu 
    210                 215                 220                 


Leu Ile Ser Gly Leu Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Met 
225                 230                 235                 240 


Ile Trp His Ser Ser Ala Ala Val Phe Gly Gly Gly Thr Gln Leu Thr 
                245                 250                 255     


Val Leu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            260                 265                 270         


Ser Met Ala Arg Ala Val Gly Ile Asp Leu Gly Thr Thr Asn Ser Val 
        275                 280                 285             


Val Ser Val Leu Glu Gly Gly Asp Pro Val Val Val Ala Asn Ser Glu 
    290                 295                 300                 


Gly Ser Arg Thr Thr Pro Ser Ile Val Ala Phe Ala Arg Asn Gly Glu 
305                 310                 315                 320 


Val Leu Val Gly Gln Pro Ala Lys Asn Gln Ala Val Thr Asn Val Asp 
                325                 330                 335     


Arg Thr Val Arg Ser Val Lys Arg His Met Gly Ser Asp Trp Ser Ile 
            340                 345                 350         


Glu Ile Asp Gly Lys Lys Tyr Thr Ala Pro Glu Ile Ser Ala Arg Ile 
        355                 360                 365             


Leu Met Lys Leu Lys Arg Asp Ala Glu Ala Tyr Leu Gly Glu Asp Ile 
    370                 375                 380                 


Thr Asp Ala Val Ile Thr Thr Pro Ala Tyr Phe Asn Asp Ala Gln Arg 
385                 390                 395                 400 


Gln Ala Thr Lys Asp Ala Gly Gln Ile Ala Gly Leu Asn Val Leu Arg 
                405                 410                 415     


Ile Val Asn Glu Pro Thr Ala Ala Ala Leu Ala Tyr Gly Leu Asp Lys 
            420                 425                 430         


Gly Glu Lys Glu Gln Arg Ile Leu Val Phe Asp Leu Gly Gly Gly Thr 
        435                 440                 445             


Phe Asp Val Ser Leu Leu Glu Ile Gly Glu Gly Val Val Glu Val Arg 
    450                 455                 460                 


Ala Thr Ser Gly Asp Asn His Leu Gly Gly Asp Asp Trp Asp Gln Arg 
465                 470                 475                 480 


Val Val Asp Trp Leu Val Asp Lys Phe Lys Gly Thr Ser Gly Ile Asp 
                485                 490                 495     


Leu Thr Lys Asp Lys Met Ala Met Gln Arg Leu Arg Glu Ala Ala Glu 
            500                 505                 510         


Lys Ala Lys Ile Glu Leu Ser Ser Ser Gln Ser Thr Ser Ile Asn Leu 
        515                 520                 525             


Pro Tyr Ile Thr Val Asp Ala Asp Lys Asn Pro Leu Phe Leu Asp Glu 
    530                 535                 540                 


Gln Leu Thr Arg Ala Glu Phe Gln Arg Ile Thr Gln Asp Leu Leu Asp 
545                 550                 555                 560 


Arg Thr Arg Lys Pro Phe Gln Ser Val Ile Ala Asp Thr Gly Ile Ser 
                565                 570                 575     


Val Ser Glu Ile Asp His Val Val Leu Val Gly Gly Ser Thr Arg Met 
            580                 585                 590         


Pro Ala Val Thr Asp Leu Val Lys Glu Leu Thr Gly Gly Lys Glu Pro 
        595                 600                 605             


Asn Lys Gly Val Asn Pro Asp Glu Val Val Ala Val Gly Ala Ala Leu 
    610                 615                 620                 


Gln Ala Gly Val Leu Lys Gly Glu Val Lys Asp Val Leu Leu Leu Asp 
625                 630                 635                 640 


Val Thr Pro Leu Ser Leu Gly Ile Glu Thr Lys Gly Gly Phe Met Thr 
                645                 650                 655     


Arg Leu Ile Glu Arg Asn Thr Thr Ile Pro Thr Lys Arg Ser Glu Thr 
            660                 665                 670         


Phe Thr Thr Ala Asp Asp Asn Gln Pro Ser Val Gln Ile Gln Val Tyr 
        675                 680                 685             


Gln Gly Glu Arg Glu Ile Ala Ala His Asn Lys Leu Leu Gly Ser Phe 
    690                 695                 700                 


Glu Leu Thr Gly Ile Pro Pro Ala Pro Arg Gly Ile Pro Gln Ile Glu 
705                 710                 715                 720 


Val Thr Phe Asp Ile Asp Ala Asn Gly Ile Val His Val Thr Ala Lys 
                725                 730                 735     


Asp Lys Gly Thr Gly Lys Glu Asn Thr Ile Arg Ile Gln Glu Gly Ser 
            740                 745                 750         


Gly Leu Ser Lys Glu Asp Ile Asp Arg Met Ile Lys Asp Ala Glu Ala 
        755                 760                 765             


His Ala Glu Glu Asp Arg Lys Arg Arg Glu Glu Ala Asp Val Arg Asn 
    770                 775                 780                 


Gln Ala Glu Thr Leu Val Tyr Gln Thr Glu Lys Phe Val Lys Glu Gln 
785                 790                 795                 800 


Arg Glu Ala Glu Gly Gly Ser Lys Val Pro Glu Asp Thr Leu Asn Lys 
                805                 810                 815     


Val Asp Ala Ala Val Ala Glu Ala Lys Ala Ala Leu Gly Gly Ser Asp 
            820                 825                 830         


Ile Ser Ala Ile Lys Ser Ala Met Glu Lys Leu Gly Gln Glu Ser Gln 
        835                 840                 845             


Ala Leu Gly Gln Ala Ile Tyr Glu Ala Ala Gln Ala Ala Ser Gln Ala 
    850                 855                 860                 


Thr Gly Ala Ala His Pro Gly Gly Glu Pro Gly Gly Ala His Pro Gly 
865                 870                 875                 880 


Ser Ala Asp Asp Val Val Asp Ala Glu Val Val Asp Asp Gly Arg Glu 
                885                 890                 895     


Ala Lys 
        


<210>  28
<211>  915
<212>  PRT
<213>  Artificial

<220>
<223>  fusion protein

<400>  28

Gly Ser Ser Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Thr 
1               5                   10                  15      


Pro Ser Gln Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser Val 
            20                  25                  30          


Ser Ser Asn Ser Ala Thr Trp Asn Trp Ile Arg Gln Ser Pro Ser Arg 
        35                  40                  45              


Gly Leu Glu Trp Leu Gly Arg Thr Tyr Tyr Arg Ser Lys Trp Tyr Asn 
    50                  55                  60                  


Asp Tyr Ala Val Ser Val Lys Ser Arg Met Ser Ile Asn Pro Asp Thr 
65                  70                  75                  80  


Ser Lys Asn Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Pro Glu Asp 
                85                  90                  95      


Thr Ala Val Tyr Tyr Cys Ala Arg Gly Met Met Thr Tyr Tyr Tyr Gly 
            100                 105                 110         


Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Ile 
        115                 120                 125             


Leu Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gln Pro Val Leu Thr Gln Ser Ser Ser Leu Ser Ala Ser Pro 
145                 150                 155                 160 


Gly Ala Ser Ala Ser Leu Thr Cys Thr Leu Arg Ser Gly Ile Asn Val 
                165                 170                 175     


Gly Pro Tyr Arg Ile Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Pro Pro 
            180                 185                 190         


Gln Tyr Leu Leu Asn Tyr Lys Ser Asp Ser Asp Lys Gln Gln Gly Ser 
        195                 200                 205             


Gly Val Pro Ser Arg Phe Ser Gly Ser Lys Asp Ala Ser Ala Asn Ala 
    210                 215                 220                 


Gly Val Leu Leu Ile Ser Gly Leu Arg Ser Glu Asp Glu Ala Asp Tyr 
225                 230                 235                 240 


Tyr Cys Met Ile Trp His Ser Ser Ala Ala Val Phe Gly Gly Gly Thr 
                245                 250                 255     


Gln Leu Thr Val Leu Ser Gly Ile Leu Glu Gln Gln Gly Gly Gly Gly 
            260                 265                 270         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Ala Ala Met 
        275                 280                 285             


Arg Ser Met Ala Arg Ala Val Gly Ile Asp Leu Gly Thr Thr Asn Ser 
    290                 295                 300                 


Val Val Ser Val Leu Glu Gly Gly Asp Pro Val Val Val Ala Asn Ser 
305                 310                 315                 320 


Glu Gly Ser Arg Thr Thr Pro Ser Ile Val Ala Phe Ala Arg Asn Gly 
                325                 330                 335     


Glu Val Leu Val Gly Gln Pro Ala Lys Asn Gln Ala Val Thr Asn Val 
            340                 345                 350         


Asp Arg Thr Val Arg Ser Val Lys Arg His Met Gly Ser Asp Trp Ser 
        355                 360                 365             


Ile Glu Ile Asp Gly Lys Lys Tyr Thr Ala Pro Glu Ile Ser Ala Arg 
    370                 375                 380                 


Ile Leu Met Lys Leu Lys Arg Asp Ala Glu Ala Tyr Leu Gly Glu Asp 
385                 390                 395                 400 


Ile Thr Asp Ala Val Ile Thr Thr Pro Ala Tyr Phe Asn Asp Ala Gln 
                405                 410                 415     


Arg Gln Ala Thr Lys Asp Ala Gly Gln Ile Ala Gly Leu Asn Val Leu 
            420                 425                 430         


Arg Ile Val Asn Glu Pro Thr Ala Ala Ala Leu Ala Tyr Gly Leu Asp 
        435                 440                 445             


Lys Gly Glu Lys Glu Gln Arg Ile Leu Val Phe Asp Leu Gly Gly Gly 
    450                 455                 460                 


Thr Phe Asp Val Ser Leu Leu Glu Ile Gly Glu Gly Val Val Glu Val 
465                 470                 475                 480 


Arg Ala Thr Ser Gly Asp Asn His Leu Gly Gly Asp Asp Trp Asp Gln 
                485                 490                 495     


Arg Val Val Asp Trp Leu Val Asp Lys Phe Lys Gly Thr Ser Gly Ile 
            500                 505                 510         


Asp Leu Thr Lys Asp Lys Met Ala Met Gln Arg Leu Arg Glu Ala Ala 
        515                 520                 525             


Glu Lys Ala Lys Ile Glu Leu Ser Ser Ser Gln Ser Thr Ser Ile Asn 
    530                 535                 540                 


Leu Pro Tyr Ile Thr Val Asp Ala Asp Lys Asn Pro Leu Phe Leu Asp 
545                 550                 555                 560 


Glu Gln Leu Thr Arg Ala Glu Phe Gln Arg Ile Thr Gln Asp Leu Leu 
                565                 570                 575     


Asp Arg Thr Arg Lys Pro Phe Gln Ser Val Ile Ala Asp Thr Gly Ile 
            580                 585                 590         


Ser Val Ser Glu Ile Asp His Val Val Leu Val Gly Gly Ser Thr Arg 
        595                 600                 605             


Met Pro Ala Val Thr Asp Leu Val Lys Glu Leu Thr Gly Gly Lys Glu 
    610                 615                 620                 


Pro Asn Lys Gly Val Asn Pro Asp Glu Val Val Ala Val Gly Ala Ala 
625                 630                 635                 640 


Leu Gln Ala Gly Val Leu Lys Gly Glu Val Lys Asp Val Leu Leu Leu 
                645                 650                 655     


Asp Val Thr Pro Leu Ser Leu Gly Ile Glu Thr Lys Gly Gly Phe Met 
            660                 665                 670         


Thr Arg Leu Ile Glu Arg Asn Thr Thr Ile Pro Thr Lys Arg Ser Glu 
        675                 680                 685             


Thr Phe Thr Thr Ala Asp Asp Asn Gln Pro Ser Val Gln Ile Gln Val 
    690                 695                 700                 


Tyr Gln Gly Glu Arg Glu Ile Ala Ala His Asn Lys Leu Leu Gly Ser 
705                 710                 715                 720 


Phe Glu Leu Thr Gly Ile Pro Pro Ala Pro Arg Gly Ile Pro Gln Ile 
                725                 730                 735     


Glu Val Thr Phe Asp Ile Asp Ala Asn Gly Ile Val His Val Thr Ala 
            740                 745                 750         


Lys Asp Lys Gly Thr Gly Lys Glu Asn Thr Ile Arg Ile Gln Glu Gly 
        755                 760                 765             


Ser Gly Leu Ser Lys Glu Asp Ile Asp Arg Met Ile Lys Asp Ala Glu 
    770                 775                 780                 


Ala His Ala Glu Glu Asp Arg Lys Arg Arg Glu Glu Ala Asp Val Arg 
785                 790                 795                 800 


Asn Gln Ala Glu Thr Leu Val Tyr Gln Thr Glu Lys Phe Val Lys Glu 
                805                 810                 815     


Gln Arg Glu Ala Glu Gly Gly Ser Lys Val Pro Glu Asp Thr Leu Asn 
            820                 825                 830         


Lys Val Asp Ala Ala Val Ala Glu Ala Lys Ala Ala Leu Gly Gly Ser 
        835                 840                 845             


Asp Ile Ser Ala Ile Lys Ser Ala Met Glu Lys Leu Gly Gln Glu Ser 
    850                 855                 860                 


Gln Ala Leu Gly Gln Ala Ile Tyr Glu Ala Ala Gln Ala Ala Ser Gln 
865                 870                 875                 880 


Ala Thr Gly Ala Ala His Pro Gly Gly Glu Pro Gly Gly Ala His Pro 
                885                 890                 895     


Gly Ser Ala Asp Asp Val Val Asp Ala Glu Val Val Asp Asp Gly Arg 
            900                 905                 910         


Glu Ala Lys 
        915 


<210>  29
<211>  641
<212>  PRT
<213>  Artificial

<220>
<223>  fusion protein

<400>  29

Met Ala Lys Ala Ala Ala Ile Gly Ile Asp Leu Gly Thr Thr Tyr Ser 
1               5                   10                  15      


Cys Val Gly Val Phe Gln His Gly Lys Val Glu Ile Ile Ala Asn Asp 
            20                  25                  30          


Gln Gly Asn Arg Thr Thr Pro Ser Tyr Val Ala Phe Thr Asp Thr Glu 
        35                  40                  45              


Arg Leu Ile Gly Asp Ala Ala Lys Asn Gln Val Ala Leu Asn Pro Gln 
    50                  55                  60                  


Asn Thr Val Phe Asp Ala Lys Arg Leu Ile Gly Arg Lys Phe Gly Asp 
65                  70                  75                  80  


Pro Val Val Gln Ser Asp Met Lys His Trp Pro Phe Gln Val Ile Asn 
                85                  90                  95      


Asp Gly Asp Lys Pro Lys Val Gln Val Ser Tyr Lys Gly Asp Thr Lys 
            100                 105                 110         


Ala Phe Tyr Pro Glu Glu Ile Ser Ser Met Val Leu Thr Lys Met Lys 
        115                 120                 125             


Glu Ile Ala Glu Ala Tyr Leu Gly Tyr Pro Val Thr Asn Ala Val Ile 
    130                 135                 140                 


Thr Val Pro Ala Tyr Phe Asn Asp Ser Gln Arg Gln Ala Thr Lys Asp 
145                 150                 155                 160 


Ala Gly Val Ile Ala Gly Leu Asn Val Leu Arg Ile Ile Asn Glu Pro 
                165                 170                 175     


Thr Ala Ala Ala Ile Ala Tyr Gly Leu Asp Arg Thr Gly Lys Gly Glu 
            180                 185                 190         


Arg Asn Val Leu Ile Phe Asp Leu Gly Gly Gly Thr Phe Asp Val Ser 
        195                 200                 205             


Ile Leu Thr Ile Asp Asp Gly Ile Phe Glu Val Lys Ala Thr Ala Gly 
    210                 215                 220                 


Asp Thr His Leu Gly Gly Glu Asp Phe Asp Asn Arg Leu Val Asn His 
225                 230                 235                 240 


Phe Val Glu Glu Phe Lys Arg Lys His Lys Lys Asp Ile Ser Gln Asn 
                245                 250                 255     


Lys Arg Ala Val Arg Arg Leu Arg Thr Ala Cys Glu Arg Ala Lys Arg 
            260                 265                 270         


Thr Leu Ser Ser Ser Thr Gln Ala Ser Leu Glu Ile Asp Ser Leu Phe 
        275                 280                 285             


Glu Gly Ile Asp Phe Tyr Thr Ser Ile Thr Arg Ala Arg Phe Glu Glu 
    290                 295                 300                 


Leu Cys Ser Asp Leu Phe Arg Ser Thr Leu Glu Pro Val Glu Lys Ala 
305                 310                 315                 320 


Leu Arg Asp Ala Lys Leu Asp Lys Ala Gln Ile His Asp Leu Val Leu 
                325                 330                 335     


Val Gly Gly Ser Thr Arg Ile Pro Lys Val Gln Lys Leu Leu Gln Asp 
            340                 345                 350         


Phe Phe Asn Gly Arg Asp Leu Asn Lys Ser Ile Asn Pro Asp Glu Ala 
        355                 360                 365             


Val Ala Tyr Gly Ala Ala Val Gln Ala Ala Ile Leu Met Gly Asp Lys 
    370                 375                 380                 


Ser Glu Asn Val Gln Asp Leu Leu Leu Leu Asp Val Ala Pro Leu Ser 
385                 390                 395                 400 


Leu Gly Leu Glu Thr Ala Gly Gly Val Met Thr Ala Leu Ile Lys Arg 
                405                 410                 415     


Asn Ser Thr Ile Pro Thr Lys Gln Thr Gln Ile Phe Thr Thr Tyr Ser 
            420                 425                 430         


Asp Asn Gln Pro Gly Val Leu Ile Gln Val Tyr Glu Gly Glu Arg Ala 
        435                 440                 445             


Met Thr Lys Asp Asn Asn Leu Leu Gly Arg Phe Glu Leu Ser Gly Ile 
    450                 455                 460                 


Pro Pro Ala Pro Arg Gly Val Pro Gln Ile Glu Val Thr Phe Asp Ile 
465                 470                 475                 480 


Asp Ala Asn Gly Ile Leu Asn Val Thr Ala Thr Asp Lys Ser Thr Gly 
                485                 490                 495     


Lys Ala Asn Lys Ile Thr Ile Thr Asn Asp Lys Gly Arg Leu Ser Lys 
            500                 505                 510         


Glu Glu Ile Glu Arg Met Val Gln Glu Ala Glu Lys Tyr Lys Ala Glu 
        515                 520                 525             


Asp Glu Val Gln Arg Glu Arg Val Ser Ala Lys Asn Ala Leu Glu Ser 
    530                 535                 540                 


Tyr Ala Phe Asn Met Lys Ser Ala Val Glu Asp Glu Gly Leu Lys Gly 
545                 550                 555                 560 


Lys Ile Ser Glu Ala Asp Lys Lys Lys Val Leu Asp Lys Cys Gln Glu 
                565                 570                 575     


Val Ile Ser Trp Leu Asp Ala Asn Thr Leu Ala Glu Lys Asp Glu Phe 
            580                 585                 590         


Glu His Lys Arg Lys Glu Leu Glu Gln Val Cys Asn Pro Ile Ile Ser 
        595                 600                 605             


Gly Leu Tyr Gln Gly Ala Gly Gly Pro Gly Pro Gly Gly Phe Gly Ala 
    610                 615                 620                 


Gln Gly Pro Lys Gly Gly Ser Gly Ser Gly Pro Thr Ile Glu Glu Val 
625                 630                 635                 640 


Asp 
    


<210>  30
<211>  258
<212>  PRT
<213>  Artificial

<220>
<223>  fusion protein

<400>  30

Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Thr Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser Val Ser Ser Asn 
            20                  25                  30          


Ser Ala Thr Trp Asn Trp Ile Arg Gln Ser Pro Ser Arg Gly Leu Glu 
        35                  40                  45              


Trp Leu Gly Arg Thr Tyr Tyr Arg Ser Lys Trp Tyr Asn Asp Tyr Ala 
    50                  55                  60                  


Val Ser Val Lys Ser Arg Met Ser Ile Asn Pro Asp Thr Ser Lys Asn 
65                  70                  75                  80  


Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Pro Glu Asp Thr Ala Val 
                85                  90                  95      


Tyr Tyr Cys Ala Arg Gly Met Met Thr Tyr Tyr Tyr Gly Met Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Ile Leu Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
    130                 135                 140                 


Pro Val Leu Thr Gln Ser Ser Ser Leu Ser Ala Ser Pro Gly Ala Ser 
145                 150                 155                 160 


Ala Ser Leu Thr Cys Thr Leu Arg Ser Gly Ile Asn Val Gly Pro Tyr 
                165                 170                 175     


Arg Ile Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Pro Pro Gln Tyr Leu 
            180                 185                 190         


Leu Asn Tyr Lys Ser Asp Ser Asp Lys Gln Gln Gly Ser Gly Val Pro 
        195                 200                 205             


Ser Arg Phe Ser Gly Ser Lys Asp Ala Ser Ala Asn Ala Gly Val Leu 
    210                 215                 220                 


Leu Ile Ser Gly Leu Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Met 
225                 230                 235                 240 


Ile Trp His Ser Ser Ala Ala Val Phe Gly Gly Gly Thr Gln Leu Thr 
                245                 250                 255     


Val Leu 
        


