                         SEQUENCE LISTING

<110>  The Brigham and Women's Hospital
       Kahn, Josephine
       Jaiswal, Siddhartha
       Ebert, Benjamin
 
<120>  COMPOSITIONS AND METHODS FOR TREATING CHEMOTHERAPY RESISTANT 
       CANCER

<130>  167741-010401

<140>  PCT/US2017/021830
<141>  2017-03-10

<150>  62/306,952
<151>  2016-03-11

<160>  35    

<170>  PatentIn version 3.5

<210>  1
<211>  605
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ala Gly Leu Tyr Ser Leu Gly Val Ser Val Phe Ser Asp Gln Gly 
1               5                   10                  15      


Gly Arg Lys Tyr Met Glu Asp Val Thr Gln Ile Val Val Glu Pro Glu 
            20                  25                  30          


Pro Thr Ala Glu Glu Lys Pro Ser Pro Arg Arg Ser Leu Ser Gln Pro 
        35                  40                  45              


Leu Pro Pro Arg Pro Ser Pro Ala Ala Leu Pro Gly Gly Glu Val Ser 
    50                  55                  60                  


Gly Lys Gly Pro Ala Val Ala Ala Arg Glu Ala Arg Asp Pro Leu Pro 
65                  70                  75                  80  


Asp Ala Gly Ala Ser Pro Ala Pro Ser Arg Cys Cys Arg Arg Arg Ser 
                85                  90                  95      


Ser Val Ala Phe Phe Ala Val Cys Asp Gly His Gly Gly Arg Glu Ala 
            100                 105                 110         


Ala Gln Phe Ala Arg Glu His Leu Trp Gly Phe Ile Lys Lys Gln Lys 
        115                 120                 125             


Gly Phe Thr Ser Ser Glu Pro Ala Lys Val Cys Ala Ala Ile Arg Lys 
    130                 135                 140                 


Gly Phe Leu Ala Cys His Leu Ala Met Trp Lys Lys Leu Ala Glu Trp 
145                 150                 155                 160 


Pro Lys Thr Met Thr Gly Leu Pro Ser Thr Ser Gly Thr Thr Ala Ser 
                165                 170                 175     


Val Val Ile Ile Arg Gly Met Lys Met Tyr Val Ala His Val Gly Asp 
            180                 185                 190         


Ser Gly Val Val Leu Gly Ile Gln Asp Asp Pro Lys Asp Asp Phe Val 
        195                 200                 205             


Arg Ala Val Glu Val Thr Gln Asp His Lys Pro Glu Leu Pro Lys Glu 
    210                 215                 220                 


Arg Glu Arg Ile Glu Gly Leu Gly Gly Ser Val Met Asn Lys Ser Gly 
225                 230                 235                 240 


Val Asn Arg Val Val Trp Lys Arg Pro Arg Leu Thr His Asn Gly Pro 
                245                 250                 255     


Val Arg Arg Ser Thr Val Ile Asp Gln Ile Pro Phe Leu Ala Val Ala 
            260                 265                 270         


Arg Ala Leu Gly Asp Leu Trp Ser Tyr Asp Phe Phe Ser Gly Glu Phe 
        275                 280                 285             


Val Val Ser Pro Glu Pro Asp Thr Ser Val His Thr Leu Asp Pro Gln 
    290                 295                 300                 


Lys His Lys Tyr Ile Ile Leu Gly Ser Asp Gly Leu Trp Asn Met Ile 
305                 310                 315                 320 


Pro Pro Gln Asp Ala Ile Ser Met Cys Gln Asp Gln Glu Glu Lys Lys 
                325                 330                 335     


Tyr Leu Met Gly Glu His Gly Gln Ser Cys Ala Lys Met Leu Val Asn 
            340                 345                 350         


Arg Ala Leu Gly Arg Trp Arg Gln Arg Met Leu Arg Ala Asp Asn Thr 
        355                 360                 365             


Ser Ala Ile Val Ile Cys Ile Ser Pro Glu Val Asp Asn Gln Gly Asn 
    370                 375                 380                 


Phe Thr Asn Glu Asp Glu Leu Tyr Leu Asn Leu Thr Asp Ser Pro Ser 
385                 390                 395                 400 


Tyr Asn Ser Gln Glu Thr Cys Val Met Thr Pro Ser Pro Cys Ser Thr 
                405                 410                 415     


Pro Pro Val Lys Ser Leu Glu Glu Asp Pro Trp Pro Arg Val Asn Ser 
            420                 425                 430         


Lys Asp His Ile Pro Ala Leu Val Arg Ser Asn Ala Phe Ser Glu Asn 
        435                 440                 445             


Phe Leu Glu Val Ser Ala Glu Ile Ala Arg Glu Asn Val Gln Gly Val 
    450                 455                 460                 


Val Ile Pro Ser Lys Asp Pro Glu Pro Leu Glu Glu Asn Cys Ala Lys 
465                 470                 475                 480 


Ala Leu Thr Leu Arg Ile His Asp Ser Leu Asn Asn Ser Leu Pro Ile 
                485                 490                 495     


Gly Leu Val Pro Thr Asn Ser Thr Asn Thr Val Met Asp Gln Lys Asn 
            500                 505                 510         


Leu Lys Met Ser Thr Pro Gly Gln Met Lys Ala Gln Glu Ile Glu Arg 
        515                 520                 525             


Thr Pro Pro Thr Asn Phe Lys Arg Thr Leu Glu Glu Ser Asn Ser Gly 
    530                 535                 540                 


Pro Leu Met Lys Lys His Arg Arg Asn Gly Leu Ser Arg Ser Ser Gly 
545                 550                 555                 560 


Ala Gln Pro Ala Ser Leu Pro Thr Thr Ser Gln Arg Lys Asn Ser Val 
                565                 570                 575     


Lys Leu Thr Met Arg Arg Arg Leu Arg Gly Gln Lys Lys Ile Gly Asn 
            580                 585                 590         


Pro Leu Leu His Gln His Arg Lys Thr Val Cys Val Cys 
        595                 600                 605 


<210>  2
<211>  4790
<212>  DNA
<213>  Homo sapiens

<400>  2
ggggaagcgc agtgcgcagg cgcaactgcc tggctctgct cgctccggcg ctccggccca       60

gctctcgcgg acaagtccag acatcgcgcg cccccccttc tccgggtccg ccccctcccc      120

cttctcggcg tcgtcgaaga taaacaatag ttggccggcg agcgcctagt gtgtctcccg      180

ccgccggatt cggcgggctg cgtgggaccg gcgggatccc ggccagccgg ccatggcggg      240

gctgtactcg ctgggagtga gcgtcttctc cgaccagggc gggaggaagt acatggagga      300

cgttactcaa atcgttgtgg agcccgaacc gacggctgaa gaaaagccct cgccgcggcg      360

gtcgctgtct cagccgttgc ctccgcggcc gtcgccggcc gcccttcccg gcggcgaagt      420

ctcggggaaa ggcccagcgg tggcagcccg agaggctcgc gaccctctcc cggacgccgg      480

ggcctcgccg gcacctagcc gctgctgccg ccgccgttcc tccgtggcct ttttcgccgt      540

gtgcgacggg cacggcgggc gggaggcggc acagtttgcc cgggagcact tgtggggttt      600

catcaagaag cagaagggtt tcacctcgtc cgagccggct aaggtttgcg ctgccatccg      660

caaaggcttt ctcgcttgtc accttgccat gtggaagaaa ctggcggaat ggccaaagac      720

tatgacgggt cttcctagca catcagggac aactgccagt gtggtcatca ttcggggcat      780

gaagatgtat gtagctcacg taggtgactc aggggtggtt cttggaattc aggatgaccc      840

gaaggatgac tttgtcagag ctgtggaggt gacacaggac cataagccag aacttcccaa      900

ggaaagagaa cgaatcgaag gacttggtgg gagtgtaatg aacaagtctg gggtgaatcg      960

tgtagtttgg aaacgacctc gactcactca caatggacct gttagaagga gcacagttat     1020

tgaccagatt ccttttctgg cagtagcaag agcacttggt gatttgtgga gctatgattt     1080

cttcagtggt gaatttgtgg tgtcacctga accagacaca agtgtccaca ctcttgaccc     1140

tcagaagcac aagtatatta tattggggag tgatggactt tggaatatga ttccaccaca     1200

agatgccatc tcaatgtgcc aggaccaaga ggagaaaaaa tacctgatgg gtgagcatgg     1260

acaatcttgt gccaaaatgc ttgtgaatcg agcattgggc cgctggaggc agcgtatgct     1320

ccgagcagat aacactagtg ccatagtaat ctgcatctct ccagaagtgg acaatcaggg     1380

aaactttacc aatgaagatg agttatacct gaacctgact gacagccctt cctataatag     1440

tcaagaaacc tgtgtgatga ctccttcccc atgttctaca ccaccagtca agtcactgga     1500

ggaggatcca tggccaaggg tgaattctaa ggaccatata cctgccctgg ttcgtagcaa     1560

tgccttctca gagaattttt tagaggtttc agctgagata gctcgagaga atgtccaagg     1620

tgtagtcata ccctcaaaag atccagaacc acttgaagaa aattgcgcta aagccctgac     1680

tttaaggata catgattctt tgaataatag ccttccaatt ggccttgtgc ctactaattc     1740

aacaaacact gtcatggacc aaaaaaattt gaagatgtca actcctggcc aaatgaaagc     1800

ccaagaaatt gaaagaaccc ctccaacaaa ctttaaaagg acattagaag agtccaattc     1860

tggccccctg atgaagaagc atagacgaaa tggcttaagt cgaagtagtg gtgctcagcc     1920

tgcaagtctc cccacaacct cacagcgaaa gaactctgtt aaactcacca tgcgacgcag     1980

acttaggggc cagaagaaaa ttggaaatcc tttacttcat caacacagga aaactgtttg     2040

tgtttgctga aatgcatctg ggaaatgagg tttttccaaa cttaggatat aagagggctt     2100

tttaaatttg gtgccgatgt tgaacttttt ttaaggggag aaaattaaaa gaaatataca     2160

gtttgacttt ttggaattca gcagttttat cctggccttg tacttgcttg tattgtaaat     2220

gtggattttg tagatgttag ggtataagtt gctgtaaaat ttgtgtaaat ttgtatccac     2280

acaaattcag tctctgaata cacagtattc agagtctctg atacacagta attgtgacaa     2340

tagggctaaa tgtttaaaga aatcaaaaga atctattaga ttttagaaaa acatttaaac     2400

tttttaaaat acttattaaa aaatttgtat aagccacttg tcttgaaaac tgtgcaactt     2460

tttaaagtaa attattaagc agactggaaa agtgatgtat tttcatagtg acctgtgttt     2520

cacttaatgt ttcttagagc caagtgtctt ttaaacatta ttttttattt ctgatttcat     2580

aattcagaac taaatttttc atagaagtgt tgagccatgc tacagttagt cttgtcccaa     2640

ttaaaatact atgcagtatc tcttacatca gtagcatttt tctaaaacct tagtcatcag     2700

atatgcttac taaatcttca gcatagaagg aagtgtgttt gcctaaaaca atctaaaaca     2760

attcccttct ttttcatccc agaccaatgg cattattagg tcttaaagta gttactccct     2820

tctcgtgttt gcttaaaata tgtgaagttt tccttgctat ttcaataaca gatggtgctg     2880

ctaattccca acatttctta aattatttta tatcatacag ttttcattga ttatatgggt     2940

atatattcat ctaataaatc agtgaactgt tcctcatgtt gctgaatttg tagttgttgg     3000

tttattttaa tggtatgtac aagttgagta tcccttatcc aaaatgcttg ggaccagaag     3060

tgtttcagat tttttaaaat tttggaatat ttgctttata ctgagctttt gagtgttccc     3120

aatctgaaat tcaaaatgct ctaatgagca tttcctttga gcatcatgcc tgctctgaaa     3180

aagtttctga ttctggagca ttttggattt tggattttca gattagggat gcttaacctg     3240

gattaacatt ctgttgtgcc atgatcatgc tttacagtga gtgtatttta tttatttatt     3300

attttgtttg tttgtttgag atggagtctc actctgtcat ccaggctaga gtgcagtggc     3360

gtgatctcgg ctgactgcaa cctctgcctc ccgggttcaa gtgattctcc tgcctcaatc     3420

tctctcccca gaagctggga ttacaggtgt gtgccaccac acccggctaa tttttttttt     3480

tttttttgag atggagtcta gctctgtcat ccaggctgga gtgcagtggt gtgatctcgg     3540

ctccctgcaa cctctgcctt ctgggttcct gcgattctcc tgcctcagcc tcctgagtag     3600

ctgagattac aggcacgcgc cactgtgccc agccaatttt tgtattttta gtagagatgg     3660

ggtttcacat gtcagtcatg ctggtcttga tctcctgacc tcgtgatcca cccgcctcga     3720

cctcccaaag tactgggatt acaggcgtga gccaccgcat ccggcctgag ttttatgctt     3780

tcaatgtatt tcttacattt cagttcaagt gattttcatg tctcagcctc ctgagtagct     3840

ggaactacag gtgcgtgcca ccatgcctgg ctaagttttg tatttttagt agagatgggt     3900

tttcatcatg ttggccaaga tggtcttgat ctcttgacct catgatccac cagcctaggc     3960

ctcccaaagt gctgggatta caggtgtgag ccaccgtgcc cagccaacta tgccattatt     4020

taaccatgtc cacacattct ggttattttc aatattttgc agaagataat tcttgatcgg     4080

tgtgtcttat gccacaagga ttaaaatatg tattcattgc tacaaaacaa tatctcgaaa     4140

tttagcagtt taaaacaaca aatattatct ccagtttctg agcctcagaa atctgagagt     4200

ggtttagctg ggtgatagtc tcgtggtttt ggtcaagcta ccaaccaggg ctacaatctt     4260

tcgaaggtgt cattggggct agaagatctg cttcccgcaa gactcacagc tgttggcagg     4320

agacctcagt ttgttgccac atgttcccct ccagagggcc tctcacaaca tggcagttat     4380

ttgtccccag agcaagcaac accggagggc aaggaagaag ccatgatgtt ttttgtaacc     4440

tagcctctga aagtgtcata ccaattctgt attttgttgg tcacacagac caagtcaact     4500

acaacgtggg agactcctac acaaggcatg aattctagga ggtgggcatt tttaagtgtc     4560

atctggaagg aggctgtcac aacctggaag ttaaaagcat tgatattctg aaatacagcg     4620

tgtataacat tgttttagta gggtgtgcaa tagttatgtt ttggtaatag cattaatgaa     4680

caatgttatt ttcatcttcc agacatctgg aagattgctc tagtggagta aaacatctta     4740

atgtattttg tccctaaata aactatctca ctaacaaaaa aaaaaaaaaa                4790


<210>  3
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Generic Formula for PPM1D substrate 
       candidates


<220>
<221>  misc_feature
<222>  (1)
<223>  Xaa can be Ser, Tyr, Leu, Lys, Gly, Glu, Gln,
       Asp, Ala, Trp, Val, Thr, Asn, Met, Phe, Cys

<220>
<221>  misc_feature
<222>  (2)
<223>  Xaa can be Arg, Asp, Lys, Glu, Ala, Ser, Gln,
       Leu, Val, Thr, Pro, Gly, Tyr, Trp, Phe

<220>
<221>  misc_feature
<222>  (3)
<223>  Xaa can be Glu, Leu, Lys, Arg, Gly, Asp, Ala,
       Val, Cys, Tyr, Thr, Gln, Asn, Phe

<220>
<221>  misc_feature
<222>  (4)
<223>  Xaa can be Glu, Gly, Ser, Asp, Ala, Tyr, Pro,
       Leu, Arg, His, Val, Thr, Asn, Met, Cys

<220>
<221>  misc_feature
<222>  (5)
<223>  Xaa can be Glu, Ser, Arg, Gly, Thr, Gln, Asp,
       Ala, Tyr, Val, Pro, Asn, Met, Leu, Lys, Phe

<220>
<221>  misc_feature
<222>  (6)
<223>  Xaa can be Glu, Ala, Gln, Pro, Asp, Val, Thr,
       Asn, Leu, Lys, Gly, Tyr, Ser, Arg, His, Cys

<220>
<221>  misc_feature
<222>  (7)
<223>  Xaa can be Asp, Leu, Glu, Ser, Asn, Ala, Tyr,
       Arg, Pro, Lys, Thr, Gln, His, Gly, Cys

<220>
<221>  misc_feature
<222>  (8)
<223>  Xaa can be Ser, Thr, Tyr

<220>
<221>  misc_feature
<222>  (9)
<223>  Xaa can be Gln, Glu, Leu, Lys, Asp, Pro, Asn, 
       Gly, Lys, His, Cys, Ala

<220>
<221>  misc_feature
<222>  (10)
<223>  Xaa can be Asp, Glu, Leu, Asn, Ala, Thr, Arg,
       Gln, Pro, Lys, Gly, Cys

<220>
<221>  misc_feature
<222>  (11)
<223>  Xaa can be Glu, Ser, Asp, Thr, Leu, Lys, Gly,
       Tyr, Val, Arg, Gln, Pro, Asn, His, Phe, Ala

<220>
<221>  misc_feature
<222>  (12)
<223>  Xaa can be Glu, Asp, Ser, Leu, Gln, Gly, Phe,
       Trp, Thr, Arg, Pro, Asn, Met, Cys

<220>
<221>  misc_feature
<222>  (13)
<223>  Xaa can be Glu, Asp, Ala, Thr, Arg, Gln, Leu,
       Pro, Gly, Val, Ser, Asn, Lys, His, Phe, Cys

<220>
<221>  misc_feature
<222>  (14)
<223>  Xaa can be Asp, Lys, Glu, Ala, Pro, Thr, Ser,
       Gln, Leu, Tyr, Val, Asn, Phe

<220>
<221>  misc_feature
<222>  (15)
<223>  Xaa can be Ala, Ser, Leu, Glu, Asp, Lys, Val,
       Thr, Arg, Pro, Phe, Tyr, Gln, Asn, Gly

<400>  3

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15  


<210>  4
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  4

Cys Val Thr Arg Glu Pro Leu Thr Ala Asp Glu Glu Glu Ala Leu 
1               5                   10                  15  


<210>  5
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  5

Ser Thr Glu Asp Thr Ala Ser Ser Leu Cys Gly Glu Glu Asp Thr 
1               5                   10                  15  


<210>  6
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  6

Ser Leu Cys Gly Glu Glu Asp Thr Glu Asp Glu Glu Leu Glu Ala 
1               5                   10                  15  


<210>  7
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  7

Ser Ala Val Gly Ala Arg Gly Ser Pro Glu Thr Asn His Leu Ile 
1               5                   10                  15  


<210>  8
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  8

Leu Asp Lys Thr Ala Glu Ser Ser Leu Leu Glu Asp Glu Ile Ala 
1               5                   10                  15  


<210>  9
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  9

Tyr Trp Phe Gly Arg Asp Lys Ser Cys Glu Tyr Cys Phe Asp Glu 
1               5                   10                  15  


<210>  10
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  10

Thr Asp Lys Tyr Arg Thr Tyr Ser Lys Lys His Phe Arg Ile Phe 
1               5                   10                  15  


<210>  11
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  11

Gln Pro Leu Glu Ser Thr Gln Ser Gln Asp Phe 
1               5                   10      


<210>  12
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  12

Gln Gly Glu Ala Glu Glu Asp Ser Gln Gly Lys Glu Gly Pro Ser 
1               5                   10                  15  


<210>  13
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  13

Lys Glu Glu Glu Glu Gly Ile Ser Gln Glu Ser Ser Glu Glu Glu 
1               5                   10                  15  


<210>  14
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  14

Tyr Asp Leu Leu Arg Ala Ala Ser Glu Asn Ser Gln Asp Ala Leu 
1               5                   10                  15  


<210>  15
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  15

Phe Pro Arg Val Met Pro Leu Ser Lys Pro Val Pro Ala Thr Lys 
1               5                   10                  15  


<210>  16
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  16

Ser Tyr Lys His Arg Ser Lys Ser Arg Asp Arg Glu Gln Asp Arg 
1               5                   10                  15  


<210>  17
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  17

Val Lys Gln Glu Lys Ala Asp Thr Gln Asp Glu Trp Thr Pro Gly 
1               5                   10                  15  


<210>  18
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  18

Ala Val Glu Gly Pro Cys Pro Ser Gln Glu Ser Leu Ser Gln Glu 
1               5                   10                  15  


<210>  19
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  19

Gly Ala Glu Ala Phe Gly Asp Ser Glu Glu Asp Gly Glu Asp Val 
1               5                   10                  15  


<210>  20
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  20

Lys Arg Arg Ser Gly Lys Asn Ser Gln Glu Asp Ser Glu Asp Ser 
1               5                   10                  15  


<210>  21
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  21

Ser Gln Leu Glu Glu His Leu Ser Gln Leu Gln Asp Asn Pro Pro 
1               5                   10                  15  


<210>  22
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  22

Trp Arg Glu Arg Tyr Glu Asp Ser Gln Gln Glu Glu Ala Gln Tyr 
1               5                   10                  15  


<210>  23
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  23

Ser Ala Asp Asp Glu Glu Leu Thr Asn Asp Ser Leu Thr Leu Ser 
1               5                   10                  15  


<210>  24
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  24

Asp Ala Glu Tyr Ile Tyr Pro Ser Leu Glu Ser Asp Asp Asp Asp 
1               5                   10                  15  


<210>  25
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  25

Gly Ser Leu Asp Arg Ala Thr Ser Pro Arg Pro Arg Ala Phe Asp 
1               5                   10                  15  


<210>  26
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  26

Ser Glu Glu Glu Leu Glu His Ser Gln Asp Thr Asp Ala Asp Asp 
1               5                   10                  15  


<210>  27
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  27

Gly Phe Gly Pro Gly Asp Arg Ser His Leu Asp Ser Pro Glu Ala 
1               5                   10                  15  


<210>  28
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  28

Glu Asp Val Leu Gly Asp Glu Thr Glu Glu Glu Glu Thr Lys Pro 
1               5                   10                  15  


<210>  29
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  29

Met Arg Ala Met Asn Val Leu Thr Glu Ala Glu Glu Arg Tyr Asn 
1               5                   10                  15  


<210>  30
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  30

Ser Lys Asp Tyr Asp Val Tyr Ser Asp Asn Asp Ile Cys Ser Gln 
1               5                   10                  15  


<210>  31
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  31

Lys Lys Ala Glu Glu Asn Ala Ser Gln Glu Glu Glu Glu Ala Ala 
1               5                   10                  15  


<210>  32
<211>  1818
<212>  DNA
<213>  Homo sapiens

<400>  32
atggcggggc tgtactcgct gggagtgagc gtcttctccg accagggcgg gaggaagtac       60

atggaggacg ttactcaaat cgttgtggag cccgaaccga cggctgaaga aaagccctcg      120

ccgcggcggt cgctgtctca gccgttgcct ccgcggccgt cgccggccgc ccttcccggc      180

ggcgaagtct cggggaaagg cccagcggtg gcagcccgag aggctcgcga ccctctcccg      240

gacgccgggg cctcgccggc acctagccgc tgctgccgcc gccgttcctc cgtggccttt      300

ttcgccgtgt gcgacgggca cggcgggcgg gaggcggcac agtttgcccg ggagcacttg      360

tggggtttca tcaagaagca gaagggtttc acctcgtccg agccggctaa ggtttgcgct      420

gccatccgca aaggctttct cgcttgtcac cttgccatgt ggaagaaact ggcggaatgg      480

ccaaagacta tgacgggtct tcctagcaca tcagggacaa ctgccagtgt ggtcatcatt      540

cggggcatga agatgtatgt agctcacgta ggtgactcag gggtggttct tggaattcag      600

gatgacccga aggatgactt tgtcagagct gtggaggtga cacaggacca taagccagaa      660

cttcccaagg aaagagaacg aatcgaagga cttggtggga gtgtaatgaa caagtctggg      720

gtgaatcgtg tagtttggaa acgacctcga ctcactcaca atggacctgt tagaaggagc      780

acagttattg accagattcc ttttctggca gtagcaagag cacttggtga tttgtggagc      840

tatgatttct tcagtggtga atttgtggtg tcacctgaac cagacacaag tgtccacact      900

cttgaccctc agaagcacaa gtatattata ttggggagtg atggactttg gaatatgatt      960

ccaccacaag atgccatctc aatgtgccag gaccaagagg agaaaaaata cctgatgggt     1020

gagcatggac aatcttgtgc caaaatgctt gtgaatcgag cattgggccg ctggaggcag     1080

cgtatgctcc gagcagataa cactagtgcc atagtaatct gcatctctcc agaagtggac     1140

aatcagggaa actttaccaa tgaagatgag ttatacctga acctgactga cagcccttcc     1200

tataatagtc aagaaacctg tgtgatgact ccttccccat gttctacacc accagtcaag     1260

tcactggagg aggatccatg gccaagggtg aattctaagg accatatacc tgccctggtt     1320

cgtagcaatg ccttctcaga gaatttttta gaggtttcag ctgagatagc tcgagagaat     1380

gtccaaggtg tagtcatacc ctcaaaagat ccagaaccac ttgaagaaaa ttgcgctaaa     1440

gccctgactt taaggataca tgattctttg aataatagcc ttccaattgg ccttgtgcct     1500

actaattcaa caaacactgt catggaccaa aaaaatttga agatgtcaac tcctggccaa     1560

atgaaagccc aagaaattga aagaacccct ccaacaaact ttaaaaggac attagaagag     1620

tccaattctg gccccctgat gaagaagcat agacgaaatg gcttaagtcg aagtagtggt     1680

gctcagcctg caagtctccc cacaacctca cagcgaaaga actctgttaa actcaccatg     1740

cgacgcagac ttaggggcca gaagaaaatt ggaaatcctt tacttcatca acacaggaaa     1800

actgtttgtg tttgctga                                                   1818


<210>  33
<211>  1437
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic

       polynucleotide

<400>  33
atggcggggc tgtactcgct gggagtgagc gtcttctccg accagggcgg gaggaagtac       60

atggaggacg ttactcaaat cgttgtggag cccgaaccga cggctgaaga aaagccctcg      120

ccgcggcggt cgctgtctca gccgttgcct ccgcggccgt cgccggccgc ccttcccggc      180

ggcgaagtct cggggaaagg cccagcggtg gcagcccgag aggctcgcga ccctctcccg      240

gacgccgggg cctcgccggc acctagccgc tgctgccgcc gccgttcctc cgtggccttt      300

ttcgccgtgt gcgacgggca cggcgggcgg gaggcggcac agtttgcccg ggagcacttg      360

tggggtttca tcaagaagca gaagggtttc acctcgtccg agccggctaa ggtttgcgct      420

gccatccgca aaggctttct cgcttgtcac cttgccatgt ggaagaaact ggcggaatgg      480

ccaaagacta tgacgggtct tcctagcaca tcagggacaa ctgccagtgt ggtcatcatt      540

cggggcatga agatgtatgt agctcacgta ggtgactcag gggtggttct tggaattcag      600

gatgacccga aggatgactt tgtcagagct gtggaggtga cacaggacca taagccagaa      660

cttcccaagg aaagagaacg aatcgaagga cttggtggga gtgtaatgaa caagtctggg      720

gtgaatcgtg tagtttggaa acgacctcga ctcactcaca atggacctgt tagaaggagc      780

acagttattg accagattcc ttttctggca gtagcaagag cacttggtga tttgtggagc      840

tatgatttct tcagtggtga atttgtggtg tcacctgaac cagacacaag tgtccacact      900

cttgaccctc agaagcacaa gtatattata ttggggagtg atggactttg gaatatgatt      960

ccaccacaag atgccatctc aatgtgccag gaccaagagg agaaaaaata cctgatgggt     1020

gagcatggac aatcttgtgc caaaatgctt gtgaatcgag cattgggccg ctggaggcag     1080

cgtatgctcc gagcagataa cactagtgcc atagtaatct gcatctctcc agaagtggac     1140

aatcagggaa actttaccaa tgaagatgag ttatacctga acctgactga cagcccttcc     1200

tataatagtc aagaaacctg tgtgatgact ccttccccat gttctacacc accagtcaag     1260

tcactggagg aggatccatg gccaagggtg aattctaagg accatatacc tgccctggtt     1320

cgtagcaatg ccttctcaga gaatttttta gaggtttcag ctgagatagc tcgagagaat     1380

gtccaaggtg tagtcatacc ctcaaaagat ccagaaccac ttgaagaaaa ttgctaa        1437


<210>  34
<211>  1428
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic

       polynucleotide

<400>  34
atggcggggc tgtactcgct gggagtgagc gtcttctccg accagggcgg gaggaagtac       60

atggaggacg ttactcaaat cgttgtggag cccgaaccga cggctgaaga aaagccctcg      120

ccgcggcggt cgctgtctca gccgttgcct ccgcggccgt cgccggccgc ccttcccggc      180

ggcgaagtct cggggaaagg cccagcggtg gcagcccgag aggctcgcga ccctctcccg      240

gacgccgggg cctcgccggc acctagccgc tgctgccgcc gccgttcctc cgtggccttt      300

ttcgccgtgt gcgacgggca cggcgggcgg gaggcggcac agtttgcccg ggagcacttg      360

tggggtttca tcaagaagca gaagggtttc acctcgtccg agccggctaa ggtttgcgct      420

gccatccgca aaggctttct cgcttgtcac cttgccatgt ggaagaaact ggcggaatgg      480

ccaaagacta tgacgggtct tcctagcaca tcagggacaa ctgccagtgt ggtcatcatt      540

cggggcatga agatgtatgt agctcacgta ggtgactcag gggtggttct tggaattcag      600

gatgacccga aggatgactt tgtcagagct gtggaggtga cacaggacca taagccagaa      660

cttcccaagg aaagagaacg aatcgaagga cttggtggga gtgtaatgaa caagtctggg      720

gtgaatcgtg tagtttggaa acgacctcga ctcactcaca atggacctgt tagaaggagc      780

acagttattg accagattcc ttttctggca gtagcaagag cacttggtga tttgtggagc      840

tatgatttct tcagtggtga atttgtggtg tcacctgaac cagacacaag tgtccacact      900

cttgaccctc agaagcacaa gtatattata ttggggagtg atggactttg gaatatgatt      960

ccaccacaag atgccatctc aatgtgccag gaccaagagg agaaaaaata cctgatgggt     1020

gagcatggac aatcttgtgc caaaatgctt gtgaatcgag cattgggccg ctggaggcag     1080

cgtatgctcc gagcagataa cactagtgcc atagtaatct gcatctctcc agaagtggac     1140

aatcagggaa actttaccaa tgaagatgag ttatacctga acctgactga cagcccttcc     1200

tataatagtc aagaaacctg tgtgatgact ccttccccat gttctacacc accagtcaag     1260

tcactggagg aggatccatg gccaagggtg aattctaagg accatatacc tgccctggtt     1320

cgtagcaatg ccttctcaga gaatttttta gaggtttcag ctgagatagc tcgagagaat     1380

gtccaaggtg tagtcatacc ctcaaaagat ccagaaccac ttgaatga                  1428


<210>  35
<211>  165
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic

       polynucleotide

<400>  35
cgaaatggct taagtcgaag tagtggtgct cagcctgcaa gtctccccac aacctcacag       60

cgaaagaact ctgttaaact caccatgcga cgcagactta ggggccagaa gaaaattgga      120

aatcctttac ttcatcaaca caggaaaact gtttgtgttt gctga                      165


