                               SEQUENCE LISTING

<110> THE JOHNS HOPKINS UNIVERSITY
 
<120> METHODS OF PRODUCING AGGREGATE-FREE MONOMERIC DIPHTHERIA TOXIN 
      FUSION PROTEINS AND THERAPEUTIC USES

<130> P13869-02

<140>
<141>

<150> 62/306,281
<151> 2016-03-10

<160> 48    

<170> PatentIn version 3.5

<210> 1
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 1
ttaggatagc taagtccat                                                    19


<210> 2
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 2
ttgatttcag agcaccctta taattaggat agctaagtcc at                          42


<210> 3
<211> 1711
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 3
ttgatttcag agcaccctta taattaggat agctaagtcc attattttat gagtcctggt       60

aaggggatac gttgtgagca gaaaactgtt tgcgtcaatc ttaatagggg cgctactggg      120

gataggggcc ccaccttcag cccatgcagg cgctgatgat gttgttgatt cttctaaatc      180

ttttgtgatg gaaaactttt cttcgtacca cgggactaaa cctggttatg tagattccat      240

tcaaaaaggt atacaaaagc caaaatctgg tacacaagga aattatgacg atgattggaa      300

agggttttat agtaccgaca ataaatacga cgctgcggga tactctgtag ataatgaaaa      360

cccgctctct ggaaaagctg gaggcgtggt caaagtgacg tatccaggac tgacgaaggt      420

tctcgcacta aaagtggata atgccgaaac tattaagaaa gagttaggtt taagtctcac      480

tgaaccgttg atggagcaag tcggaacgga agagtttatc aaaaggttcg gtgatggtgc      540

ttcgcgtgta gtgctcagcc ttcccttcgc tgaggggagt tctagcgttg aatatattaa      600

taactgggaa caggcgaaag cgttaagcgt agaacttgag attaattttg aaacccgtgg      660

aaaacgtggc caagatgcga tgtatgagta tatggctcaa gcctgtgcag gaaatcgtgt      720

caggcgatca gtaggtagct cattgtcatg catcaacctg gattgggatg ttatccgtga      780

taaaactaaa actaagatcg aatctctgaa agaacacggt ccgatcaaaa acaaaatgag      840

cgaaagcccg aacaaaactg tatctgaaga aaaagctaaa cagtacctgg aagaattcca      900

ccagactgca ctggaacacc cggaactgtc tgaacttaag accgttactg gtaccaaccc      960

ggtattcgct ggtgctaact acgctgcttg ggcagtaaac gttgctcagg ttatcgatag     1020

cgaaactgct gataacctgg aaaaaactac cgcggctctg tctatcctgc cgggtatcgg     1080

tagcgtaatg ggcatcgcag acggcgccgt tcaccacaac actgaagaaa tcgttgcaca     1140

gtctatcgct ctgagctctc tgatggttgc tcaggccatc ccgctggtag gtgaactggt     1200

tgatatcggt ttcgctgcat acaacttcgt tgaaagcatc atcaacctgt tccaggttgt     1260

tcacaactct tacaaccgcc cggcttactc tccgggtcac aagacgcatg cacctacttc     1320

tagctctacc aagaaaaccc agctgcagct cgagcacctg ctgctggatt tgcagatgat     1380

cctgaacggt atcaacaatt acaagaaccc gaaactgacg cgtatgctga ccttcaagtt     1440

ctacatgccg aagaaggcca ccgaactgaa acacctgcag tgtctagaag aagaactgaa     1500

accgctggag gaagttctga acctggctca gtctaaaaac ttccacctgc ggccgcgtga     1560

cctgatctct aacatcaacg taatcgttct ggaactgaag ggctctgaaa ccaccttcat     1620

gtgtgaatac gctgatgaga ccgcaaccat cgtagaattc ctgaaccgtt ggatcacctt     1680

ctgtcagtct atcatctcta ccctgacctg a                                    1711


<210> 4
<211> 75
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 4
gtgagcagaa aactgtttgc gtcaatctta ataggggcgc tactggggat aggggcccca       60

ccttcagccc atgca                                                        75


<210> 5
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 5
Met Ser Arg Lys Leu Phe Ala Ser Ile Leu Ile Gly Ala Leu Leu Gly 
1               5                   10                  15      


Ile Gly Ala Pro Pro Ser Ala His Ala 
            20                  25  


<210> 6
<211> 1566
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 6
atgggcgctg atgatgttgt tgattcttct aaatcttttg tgatggaaaa cttttcttcg       60

taccacggga ctaaacctgg ttatgtagat tccattcaaa aaggtataca aaagccaaaa      120

tctggtacac aaggaaatta tgacgatgat tggaaagggt tttatagtac cgacaataaa      180

tacgacgctg cgggatactc tgtagataat gaaaacccgc tctctggaaa agctggaggc      240

gtggtcaaag tgacgtatcc aggactgacg aaggttctcg cactaaaagt ggataatgcc      300

gaaactatta agaaagagtt aggtttaagt ctcactgaac cgttgatgga gcaagtcgga      360

acggaagagt ttatcaaaag gttcggtgat ggtgcttcgc gtgtagtgct cagccttccc      420

ttcgctgagg ggagttctag cgttgaatat attaataact gggaacaggc gaaagcgtta      480

agcgtagaac ttgagattaa ttttgaaacc cgtggaaaac gtggccaaga tgcgatgtat      540

gagtatatgg ctcaagcctg tgcaggaaat cgtgtcaggc gatcagtagg tagctcattg      600

tcatgcatca acctggattg ggatgttatc cgtgataaaa ctaaaactaa gatcgaatct      660

ctgaaagaac acggtccgat caaaaacaaa atgagcgaaa gcccgaacaa aactgtatct      720

gaagaaaaag ctaaacagta cctggaagaa ttccaccaga ctgcactgga acacccggaa      780

ctgtctgaac ttaagaccgt tactggtacc aacccggtat tcgctggtgc taactacgct      840

gcttgggcag taaacgttgc tcaggttatc gatagcgaaa ctgctgataa cctggaaaaa      900

actaccgcgg ctctgtctat cctgccgggt atcggtagcg taatgggcat cgcagacggc      960

gccgttcacc acaacactga agaaatcgtt gcacagtcta tcgctctgag ctctctgatg     1020

gttgctcagg ccatcccgct ggtaggtgaa ctggttgata tcggtttcgc tgcatacaac     1080

ttcgttgaaa gcatcatcaa cctgttccag gttgttcaca actcttacaa ccgcccggct     1140

tactctccgg gtcacaagac gcatgcacct acttctagct ctaccaagaa aacccagctg     1200

cagctcgagc acctgctgct ggatttgcag atgatcctga acggtatcaa caattacaag     1260

aacccgaaac tgacgcgtat gctgaccttc aagttctaca tgccgaagaa ggccaccgaa     1320

ctgaaacacc tgcagtgtct agaagaagaa ctgaaaccgc tggaggaagt tctgaacctg     1380

gctcagtcta aaaacttcca cctgcggccg cgtgacctga tctctaacat caacgtaatc     1440

gttctggaac tgaagggctc tgaaaccacc ttcatgtgtg aatacgctga tgagaccgca     1500

accatcgtag aattcctgaa ccgttggatc accttctgtc agtctatcat ctctaccctg     1560

acctga                                                                1566


<210> 7
<211> 1566
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 7
atgggcgctg atgatgttgc tgattcttct aaatcttttg tgatggaaaa cttttcttcg       60

taccacggga ctaaacctgg ttatgtagat tccattcaaa aaggtataca aaagccaaaa      120

tctggtacac aaggaaatta tgacgatgat tggaaagggt tttatagtac cgacaataaa      180

tacgacgctg cgggatactc tgtagataat gaaaacccgc tctctggaaa agctggaggc      240

gtggtcaaag tgacgtatcc aggactgacg aaggttctcg cactaaaagt ggataatgcc      300

gaaactatta agaaagagtt aggtttaagt ctcactgaac cgttgatgga gcaagtcgga      360

acggaagagt ttatcaaaag gttcggtgat ggtgcttcgc gtgtagtgct cagccttccc      420

ttcgctgagg ggagttctag cgttgaatat attaataact gggaacaggc gaaagcgtta      480

agcgtagaac ttgagattaa ttttgaaacc cgtggaaaac gtggccaaga tgcgatgtat      540

gagtatatgg ctcaagcctg tgcaggaaat cgtgtcaggc gatcagtagg tagctcattg      600

tcatgcatca acctggattg ggatgttatc cgtgataaaa ctaaaactaa gatcgaatct      660

ctgaaagaac acggtccgat caaaaacaaa atgagcgaaa gcccgaacaa aactgtatct      720

gaagaaaaag ctaaacagta cctggaagaa ttccaccaga ctgcactgga acacccggaa      780

ctgtctgaac ttaagaccgt tactggtacc aacccggtat tcgctggtgc taactacgct      840

gcttgggcag taaacgttgc tcaggttatc gatagcgaaa ctgctgataa cctggaaaaa      900

actaccgcgg ctctgtctat cctgccgggt atcggtagcg taatgggcat cgcagacggc      960

gccgttcacc acaacactga agaaatcgtt gcacagtcta tcgctctgag ctctctgatg     1020

gttgctcagg ccatcccgct ggtaggtgaa ctggttgata tcggtttcgc tgcatacaac     1080

ttcgttgaaa gcatcatcaa cctgttccag gttgttcaca actcttacaa ccgcccggct     1140

tactctccgg gtcacaagac gcatgcacct acttctagct ctaccaagaa aacccagctg     1200

cagctcgagc acctgctgct ggatttgcag atgatcctga acggtatcaa caattacaag     1260

aacccgaaac tgacgcgtat gctgaccttc aagttctaca tgccgaagaa ggccaccgaa     1320

ctgaaacacc tgctgcagtg tctagaagaa gaactgaaac cgctggagga agttctgaac     1380

ctggctcagt ctaaaaactt ccacctgcgg ccgcgtgacc tgatctctaa catcaacgta     1440

atcgttctgg aactgaaggg ctctgaaacc accttcatgt gtgaatacgc tgatgagacc     1500

gcaaccatcg tagaattcct gaaccgttgg atcaccttct gtcagtctat catctctacc     1560

ctgacc                                                                1566


<210> 8
<211> 1638
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 8
gtgagcagaa aactgtttgc gtcaatctta ataggggcgc tactggggat aggggcccca       60

ccttcagccc atgcaggcgc tgatgatgtt gctgattctt ctaaatcttt tgtgatggaa      120

aacttttctt cgtaccacgg gactaaacct ggttatgtag attccattca aaaaggtata      180

caaaagccaa aatctggtac acaaggaaat tatgacgatg attggaaagg gttttatagt      240

accgacaata aatacgacgc tgcgggatac tctgtagata atgaaaaccc gctctctgga      300

aaagctggag gcgtggtcaa agtgacgtat ccaggactga cgaaggttct cgcactaaaa      360

gtggataatg ccgaaactat taagaaagag ttaggtttaa gtctcactga accgttgatg      420

gagcaagtcg gaacggaaga gtttatcaaa aggttcggtg atggtgcttc gcgtgtagtg      480

ctcagccttc ccttcgctga ggggagttct agcgttgaat atattaataa ctgggaacag      540

gcgaaagcgt taagcgtaga acttgagatt aattttgaaa cccgtggaaa acgtggccaa      600

gatgcgatgt atgagtatat ggctcaagcc tgtgcaggaa atcgtgtcag gcgatcagta      660

ggtagctcat tgtcatgcat caacctggat tgggatgtta tccgtgataa aactaaaact      720

aagatcgaat ctctgaaaga acacggtccg atcaaaaaca aaatgagcga aagcccgaac      780

aaaactgtat ctgaagaaaa agctaaacag tacctggaag aattccacca gactgcactg      840

gaacacccgg aactgtctga acttaagacc gttactggta ccaacccggt attcgctggt      900

gctaactacg ctgcttgggc agtaaacgtt gctcaggtta tcgatagcga aactgctgat      960

aacctggaaa aaactaccgc ggctctgtct atcctgccgg gtatcggtag cgtaatgggc     1020

atcgcagacg gcgccgttca ccacaacact gaagaaatcg ttgcacagtc tatcgctctg     1080

agctctctga tggttgctca ggccatcccg ctggtaggtg aactggttga tatcggtttc     1140

gctgcataca acttcgttga aagcatcatc aacctgttcc aggttgttca caactcttac     1200

aaccgcccgg cttactctcc gggtcacaag acgcatgcac ctacttctag ctctaccaag     1260

aaaacccagc tgcagctcga gcacctgctg ctggatttgc agatgatcct gaacggtatc     1320

aacaattaca agaacccgaa actgacgcgt atgctgacct tcaagttcta catgccgaag     1380

aaggccaccg aactgaaaca cctgcagtgt ctagaagaag aactgaaacc gctggaggaa     1440

gttctgaacc tggctcagtc taaaaacttc cacctgcggc cgcgtgacct gatctctaac     1500

atcaacgtaa tcgttctgga actgaagggc tctgaaacca ccttcatgtg tgaatacgct     1560

gatgagaccg caaccatcgt agaattcctg aaccgttgga tcaccttctg tcagtctatc     1620

atctctaccc tgacctga                                                   1638


<210> 9
<211> 402
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 9
gcacctactt ctagctctac caagaaaacc cagctgcagc tcgagcacct gctgctggat       60

ttgcagatga tcctgaacgg tatcaacaat tacaagaacc cgaaactgac gcgtatgctg      120

accttcaagt tctacatgcc gaagaaggcc accgaactga aacacctgca gtgtctagaa      180

gaagaactga aaccgctgga ggaagttctg aacctggctc agtctaaaaa cttccacctg      240

cggccgcgtg acctgatctc taacatcaac gtaatcgttc tggaactgaa gggctctgaa      300

accaccttca tgtgtgaata cgctgatgag accgcaacca tcgtagaatt cctgaaccgt      360

tggatcacct tctgtcagtc tatcatctct accctgacct ga                         402


<210> 10
<211> 521
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 10
Met Gly Ala Asp Asp Val Val Asp Ser Ser Lys Ser Phe Val Met Glu 
1               5                   10                  15      


Asn Phe Ser Ser Tyr His Gly Thr Lys Pro Gly Tyr Val Asp Ser Ile 
            20                  25                  30          


Gln Lys Gly Ile Gln Lys Pro Lys Ser Gly Thr Gln Gly Asn Tyr Asp 
        35                  40                  45              


Asp Asp Trp Lys Gly Phe Tyr Ser Thr Asp Asn Lys Tyr Asp Ala Ala 
    50                  55                  60                  


Gly Tyr Ser Val Asp Asn Glu Asn Pro Leu Ser Gly Lys Ala Gly Gly 
65                  70                  75                  80  


Val Val Lys Val Thr Tyr Pro Gly Leu Thr Lys Val Leu Ala Leu Lys 
                85                  90                  95      


Val Asp Asn Ala Glu Thr Ile Lys Lys Glu Leu Gly Leu Ser Leu Thr 
            100                 105                 110         


Glu Pro Leu Met Glu Gln Val Gly Thr Glu Glu Phe Ile Lys Arg Phe 
        115                 120                 125             


Gly Asp Gly Ala Ser Arg Val Val Leu Ser Leu Pro Phe Ala Glu Gly 
    130                 135                 140                 


Ser Ser Ser Val Glu Tyr Ile Asn Asn Trp Glu Gln Ala Lys Ala Leu 
145                 150                 155                 160 


Ser Val Glu Leu Glu Ile Asn Phe Glu Thr Arg Gly Lys Arg Gly Gln 
                165                 170                 175     


Asp Ala Met Tyr Glu Tyr Met Ala Gln Ala Cys Ala Gly Asn Arg Val 
            180                 185                 190         


Arg Arg Ser Val Gly Ser Ser Leu Ser Cys Ile Asn Leu Asp Trp Asp 
        195                 200                 205             


Val Ile Arg Asp Lys Thr Lys Thr Lys Ile Glu Ser Leu Lys Glu His 
    210                 215                 220                 


Gly Pro Ile Lys Asn Lys Met Ser Glu Ser Pro Asn Lys Thr Val Ser 
225                 230                 235                 240 


Glu Glu Lys Ala Lys Gln Tyr Leu Glu Glu Phe His Gln Thr Ala Leu 
                245                 250                 255     


Glu His Pro Glu Leu Ser Glu Leu Lys Thr Val Thr Gly Thr Asn Pro 
            260                 265                 270         


Val Phe Ala Gly Ala Asn Tyr Ala Ala Trp Ala Val Asn Val Ala Gln 
        275                 280                 285             


Val Ile Asp Ser Glu Thr Ala Asp Asn Leu Glu Lys Thr Thr Ala Ala 
    290                 295                 300                 


Leu Ser Ile Leu Pro Gly Ile Gly Ser Val Met Gly Ile Ala Asp Gly 
305                 310                 315                 320 


Ala Val His His Asn Thr Glu Glu Ile Val Ala Gln Ser Ile Ala Leu 
                325                 330                 335     


Ser Ser Leu Met Val Ala Gln Ala Ile Pro Leu Val Gly Glu Leu Val 
            340                 345                 350         


Asp Ile Gly Phe Ala Ala Tyr Asn Phe Val Glu Ser Ile Ile Asn Leu 
        355                 360                 365             


Phe Gln Val Val His Asn Ser Tyr Asn Arg Pro Ala Tyr Ser Pro Gly 
    370                 375                 380                 


His Lys Thr His Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu 
385                 390                 395                 400 


Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile 
                405                 410                 415     


Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe 
            420                 425                 430         


Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu 
        435                 440                 445             


Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys 
    450                 455                 460                 


Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile 
465                 470                 475                 480 


Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala 
                485                 490                 495     


Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe 
            500                 505                 510         


Cys Gln Ser Ile Ile Ser Thr Leu Thr 
        515                 520     


<210> 11
<211> 560
<212> PRT
<213> Corynebacterium diphtheriae

<400> 11
Met Ser Arg Lys Leu Phe Ala Ser Ile Leu Ile Gly Ala Leu Leu Gly 
1               5                   10                  15      


Ile Gly Ala Pro Pro Ser Ala His Ala Gly Ala Asp Asp Val Val Asp 
            20                  25                  30          


Ser Ser Lys Ser Phe Val Met Glu Asn Phe Ser Ser Tyr His Gly Thr 
        35                  40                  45              


Lys Pro Gly Tyr Val Asp Ser Ile Gln Lys Gly Ile Gln Lys Pro Lys 
    50                  55                  60                  


Ser Gly Thr Gln Gly Asn Tyr Asp Asp Asp Trp Lys Gly Phe Tyr Ser 
65                  70                  75                  80  


Thr Asp Asn Lys Tyr Asp Ala Ala Gly Tyr Ser Val Asp Asn Glu Asn 
                85                  90                  95      


Pro Leu Ser Gly Lys Ala Gly Gly Val Val Lys Val Thr Tyr Pro Gly 
            100                 105                 110         


Leu Thr Lys Val Leu Ala Leu Lys Val Asp Asn Ala Glu Thr Ile Lys 
        115                 120                 125             


Lys Glu Leu Gly Leu Ser Leu Thr Glu Pro Leu Met Glu Gln Val Gly 
    130                 135                 140                 


Thr Glu Glu Phe Ile Lys Arg Phe Gly Asp Gly Ala Ser Arg Val Val 
145                 150                 155                 160 


Leu Ser Leu Pro Phe Ala Glu Gly Ser Ser Ser Val Glu Tyr Ile Asn 
                165                 170                 175     


Asn Trp Glu Gln Ala Lys Ala Leu Ser Val Glu Leu Glu Ile Asn Phe 
            180                 185                 190         


Glu Thr Arg Gly Lys Arg Gly Gln Asp Ala Met Tyr Glu Tyr Met Ala 
        195                 200                 205             


Gln Ala Cys Ala Gly Asn Arg Val Arg Arg Ser Val Gly Ser Ser Leu 
    210                 215                 220                 


Ser Cys Ile Asn Leu Asp Trp Asp Val Ile Arg Asp Lys Thr Lys Thr 
225                 230                 235                 240 


Lys Ile Glu Ser Leu Lys Glu His Gly Pro Ile Lys Asn Lys Met Ser 
                245                 250                 255     


Glu Ser Pro Asn Lys Thr Val Ser Glu Glu Lys Ala Lys Gln Tyr Leu 
            260                 265                 270         


Glu Glu Phe His Gln Thr Ala Leu Glu His Pro Glu Leu Ser Glu Leu 
        275                 280                 285             


Lys Thr Val Thr Gly Thr Asn Pro Val Phe Ala Gly Ala Asn Tyr Ala 
    290                 295                 300                 


Ala Trp Ala Val Asn Val Ala Gln Val Ile Asp Ser Glu Thr Ala Asp 
305                 310                 315                 320 


Asn Leu Glu Lys Thr Thr Ala Ala Leu Ser Ile Leu Pro Gly Ile Gly 
                325                 330                 335     


Ser Val Met Gly Ile Ala Asp Gly Ala Val His His Asn Thr Glu Glu 
            340                 345                 350         


Ile Val Ala Gln Ser Ile Ala Leu Ser Ser Leu Met Val Ala Gln Ala 
        355                 360                 365             


Ile Pro Leu Val Gly Glu Leu Val Asp Ile Gly Phe Ala Ala Tyr Asn 
    370                 375                 380                 


Phe Val Glu Ser Ile Ile Asn Leu Phe Gln Val Val His Asn Ser Tyr 
385                 390                 395                 400 


Asn Arg Pro Ala Tyr Ser Pro Gly His Lys Thr Gln Pro Phe Leu His 
                405                 410                 415     


Asp Gly Tyr Ala Val Ser Trp Asn Thr Val Glu Asp Ser Ile Ile Arg 
            420                 425                 430         


Thr Gly Phe Gln Gly Glu Ser Gly His Asp Ile Lys Ile Thr Ala Glu 
        435                 440                 445             


Asn Thr Pro Leu Pro Ile Ala Gly Val Leu Leu Pro Thr Ile Pro Gly 
    450                 455                 460                 


Lys Leu Asp Val Asn Lys Ser Lys Thr His Ile Ser Val Asn Gly Arg 
465                 470                 475                 480 


Lys Ile Arg Met Arg Cys Arg Ala Ile Asp Gly Asp Val Thr Phe Cys 
                485                 490                 495     


Arg Pro Lys Ser Pro Val Tyr Val Gly Asn Gly Val His Ala Asn Leu 
            500                 505                 510         


His Val Ala Phe His Arg Ser Ser Ser Glu Lys Ile His Ser Asn Glu 
        515                 520                 525             


Ile Ser Ser Asp Ser Ile Gly Val Leu Gly Tyr Gln Lys Thr Val Asp 
    530                 535                 540                 


His Thr Lys Val Asn Ser Lys Leu Ser Leu Phe Phe Glu Ile Lys Ser 
545                 550                 555                 560 


<210> 12
<211> 545
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 12
Met Ser Arg Lys Leu Phe Ala Ser Ile Leu Ile Gly Ala Leu Leu Gly 
1               5                   10                  15      


Ile Gly Ala Pro Pro Ser Ala His Ala Gly Ala Asp Asp Val Val Asp 
            20                  25                  30          


Ser Ser Lys Ser Phe Val Met Glu Asn Phe Ser Ser Tyr His Gly Thr 
        35                  40                  45              


Lys Pro Gly Tyr Val Asp Ser Ile Gln Lys Gly Ile Gln Lys Pro Lys 
    50                  55                  60                  


Ser Gly Thr Gln Gly Asn Tyr Asp Asp Asp Trp Lys Gly Phe Tyr Ser 
65                  70                  75                  80  


Thr Asp Asn Lys Tyr Asp Ala Ala Gly Tyr Ser Val Asp Asn Glu Asn 
                85                  90                  95      


Pro Leu Ser Gly Lys Ala Gly Gly Val Val Lys Val Thr Tyr Pro Gly 
            100                 105                 110         


Leu Thr Lys Val Leu Ala Leu Lys Val Asp Asn Ala Glu Thr Ile Lys 
        115                 120                 125             


Lys Glu Leu Gly Leu Ser Leu Thr Glu Pro Leu Met Glu Gln Val Gly 
    130                 135                 140                 


Thr Glu Glu Phe Ile Lys Arg Phe Gly Asp Gly Ala Ser Arg Val Val 
145                 150                 155                 160 


Leu Ser Leu Pro Phe Ala Glu Gly Ser Ser Ser Val Glu Tyr Ile Asn 
                165                 170                 175     


Asn Trp Glu Gln Ala Lys Ala Leu Ser Val Glu Leu Glu Ile Asn Phe 
            180                 185                 190         


Glu Thr Arg Gly Lys Arg Gly Gln Asp Ala Met Tyr Glu Tyr Met Ala 
        195                 200                 205             


Gln Ala Cys Ala Gly Asn Arg Val Arg Arg Ser Val Gly Ser Ser Leu 
    210                 215                 220                 


Ser Cys Ile Asn Leu Asp Trp Asp Val Ile Arg Asp Lys Thr Lys Thr 
225                 230                 235                 240 


Lys Ile Glu Ser Leu Lys Glu His Gly Pro Ile Lys Asn Lys Met Ser 
                245                 250                 255     


Glu Ser Pro Asn Lys Thr Val Ser Glu Glu Lys Ala Lys Gln Tyr Leu 
            260                 265                 270         


Glu Glu Phe His Gln Thr Ala Leu Glu His Pro Glu Leu Ser Glu Leu 
        275                 280                 285             


Lys Thr Val Thr Gly Thr Asn Pro Val Phe Ala Gly Ala Asn Tyr Ala 
    290                 295                 300                 


Ala Trp Ala Val Asn Val Ala Gln Val Ile Asp Ser Glu Thr Ala Asp 
305                 310                 315                 320 


Asn Leu Glu Lys Thr Thr Ala Ala Leu Ser Ile Leu Pro Gly Ile Gly 
                325                 330                 335     


Ser Val Met Gly Ile Ala Asp Gly Ala Val His His Asn Thr Glu Glu 
            340                 345                 350         


Ile Val Ala Gln Ser Ile Ala Leu Ser Ser Leu Met Val Ala Gln Ala 
        355                 360                 365             


Ile Pro Leu Val Gly Glu Leu Val Asp Ile Gly Phe Ala Ala Tyr Asn 
    370                 375                 380                 


Phe Val Glu Ser Ile Ile Asn Leu Phe Gln Val Val His Asn Ser Tyr 
385                 390                 395                 400 


Asn Arg Pro Ala Tyr Ser Pro Gly His Lys Thr His Ala Pro Thr Ser 
                405                 410                 415     


Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His Leu Leu Leu Asp 
            420                 425                 430         


Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys Asn Pro Lys Leu 
        435                 440                 445             


Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys Lys Ala Thr Glu 
    450                 455                 460                 


Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys Pro Leu Glu Glu 
465                 470                 475                 480 


Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu Arg Pro Arg Asp 
                485                 490                 495     


Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu Lys Gly Ser Glu 
            500                 505                 510         


Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala Thr Ile Val Glu 
        515                 520                 525             


Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile Ile Ser Thr Leu 
    530                 535                 540                 


Thr 
545 


<210> 13
<211> 520
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 13
Gly Ala Asp Asp Val Val Asp Ser Ser Lys Ser Phe Val Met Glu Asn 
1               5                   10                  15      


Phe Ser Ser Tyr His Gly Thr Lys Pro Gly Tyr Val Asp Ser Ile Gln 
            20                  25                  30          


Lys Gly Ile Gln Lys Pro Lys Ser Gly Thr Gln Gly Asn Tyr Asp Asp 
        35                  40                  45              


Asp Trp Lys Gly Phe Tyr Ser Thr Asp Asn Lys Tyr Asp Ala Ala Gly 
    50                  55                  60                  


Tyr Ser Val Asp Asn Glu Asn Pro Leu Ser Gly Lys Ala Gly Gly Val 
65                  70                  75                  80  


Val Lys Val Thr Tyr Pro Gly Leu Thr Lys Val Leu Ala Leu Lys Val 
                85                  90                  95      


Asp Asn Ala Glu Thr Ile Lys Lys Glu Leu Gly Leu Ser Leu Thr Glu 
            100                 105                 110         


Pro Leu Met Glu Gln Val Gly Thr Glu Glu Phe Ile Lys Arg Phe Gly 
        115                 120                 125             


Asp Gly Ala Ser Arg Val Val Leu Ser Leu Pro Phe Ala Glu Gly Ser 
    130                 135                 140                 


Ser Ser Val Glu Tyr Ile Asn Asn Trp Glu Gln Ala Lys Ala Leu Ser 
145                 150                 155                 160 


Val Glu Leu Glu Ile Asn Phe Glu Thr Arg Gly Lys Arg Gly Gln Asp 
                165                 170                 175     


Ala Met Tyr Glu Tyr Met Ala Gln Ala Cys Ala Gly Asn Arg Val Arg 
            180                 185                 190         


Arg Ser Val Gly Ser Ser Leu Ser Cys Ile Asn Leu Asp Trp Asp Val 
        195                 200                 205             


Ile Arg Asp Lys Thr Lys Thr Lys Ile Glu Ser Leu Lys Glu His Gly 
    210                 215                 220                 


Pro Ile Lys Asn Lys Met Ser Glu Ser Pro Asn Lys Thr Val Ser Glu 
225                 230                 235                 240 


Glu Lys Ala Lys Gln Tyr Leu Glu Glu Phe His Gln Thr Ala Leu Glu 
                245                 250                 255     


His Pro Glu Leu Ser Glu Leu Lys Thr Val Thr Gly Thr Asn Pro Val 
            260                 265                 270         


Phe Ala Gly Ala Asn Tyr Ala Ala Trp Ala Val Asn Val Ala Gln Val 
        275                 280                 285             


Ile Asp Ser Glu Thr Ala Asp Asn Leu Glu Lys Thr Thr Ala Ala Leu 
    290                 295                 300                 


Ser Ile Leu Pro Gly Ile Gly Ser Val Met Gly Ile Ala Asp Gly Ala 
305                 310                 315                 320 


Val His His Asn Thr Glu Glu Ile Val Ala Gln Ser Ile Ala Leu Ser 
                325                 330                 335     


Ser Leu Met Val Ala Gln Ala Ile Pro Leu Val Gly Glu Leu Val Asp 
            340                 345                 350         


Ile Gly Phe Ala Ala Tyr Asn Phe Val Glu Ser Ile Ile Asn Leu Phe 
        355                 360                 365             


Gln Val Val His Asn Ser Tyr Asn Arg Pro Ala Tyr Ser Pro Gly His 
    370                 375                 380                 


Lys Thr His Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln 
385                 390                 395                 400 


Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn 
                405                 410                 415     


Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr 
            420                 425                 430         


Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu 
        435                 440                 445             


Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn 
    450                 455                 460                 


Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val 
465                 470                 475                 480 


Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp 
                485                 490                 495     


Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys 
            500                 505                 510         


Gln Ser Ile Ile Ser Thr Leu Thr 
        515                 520 


<210> 14
<211> 545
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 14
Met Ser Arg Lys Leu Phe Ala Ser Ile Leu Ile Gly Ala Leu Leu Gly 
1               5                   10                  15      


Ile Gly Ala Pro Pro Ser Ala His Ala Gly Ala Asp Asp Val Ala Asp 
            20                  25                  30          


Ser Ser Lys Ser Phe Val Met Glu Asn Phe Ser Ser Tyr His Gly Thr 
        35                  40                  45              


Lys Pro Gly Tyr Val Asp Ser Ile Gln Lys Gly Ile Gln Lys Pro Lys 
    50                  55                  60                  


Ser Gly Thr Gln Gly Asn Tyr Asp Asp Asp Trp Lys Gly Phe Tyr Ser 
65                  70                  75                  80  


Thr Asp Asn Lys Tyr Asp Ala Ala Gly Tyr Ser Val Asp Asn Glu Asn 
                85                  90                  95      


Pro Leu Ser Gly Lys Ala Gly Gly Val Val Lys Val Thr Tyr Pro Gly 
            100                 105                 110         


Leu Thr Lys Val Leu Ala Leu Lys Val Asp Asn Ala Glu Thr Ile Lys 
        115                 120                 125             


Lys Glu Leu Gly Leu Ser Leu Thr Glu Pro Leu Met Glu Gln Val Gly 
    130                 135                 140                 


Thr Glu Glu Phe Ile Lys Arg Phe Gly Asp Gly Ala Ser Arg Val Val 
145                 150                 155                 160 


Leu Ser Leu Pro Phe Ala Glu Gly Ser Ser Ser Val Glu Tyr Ile Asn 
                165                 170                 175     


Asn Trp Glu Gln Ala Lys Ala Leu Ser Val Glu Leu Glu Ile Asn Phe 
            180                 185                 190         


Glu Thr Arg Gly Lys Arg Gly Gln Asp Ala Met Tyr Glu Tyr Met Ala 
        195                 200                 205             


Gln Ala Cys Ala Gly Asn Arg Val Arg Arg Ser Val Gly Ser Ser Leu 
    210                 215                 220                 


Ser Cys Ile Asn Leu Asp Trp Asp Val Ile Arg Asp Lys Thr Lys Thr 
225                 230                 235                 240 


Lys Ile Glu Ser Leu Lys Glu His Gly Pro Ile Lys Asn Lys Met Ser 
                245                 250                 255     


Glu Ser Pro Asn Lys Thr Val Ser Glu Glu Lys Ala Lys Gln Tyr Leu 
            260                 265                 270         


Glu Glu Phe His Gln Thr Ala Leu Glu His Pro Glu Leu Ser Glu Leu 
        275                 280                 285             


Lys Thr Val Thr Gly Thr Asn Pro Val Phe Ala Gly Ala Asn Tyr Ala 
    290                 295                 300                 


Ala Trp Ala Val Asn Val Ala Gln Val Ile Asp Ser Glu Thr Ala Asp 
305                 310                 315                 320 


Asn Leu Glu Lys Thr Thr Ala Ala Leu Ser Ile Leu Pro Gly Ile Gly 
                325                 330                 335     


Ser Val Met Gly Ile Ala Asp Gly Ala Val His His Asn Thr Glu Glu 
            340                 345                 350         


Ile Val Ala Gln Ser Ile Ala Leu Ser Ser Leu Met Val Ala Gln Ala 
        355                 360                 365             


Ile Pro Leu Val Gly Glu Leu Val Asp Ile Gly Phe Ala Ala Tyr Asn 
    370                 375                 380                 


Phe Val Glu Ser Ile Ile Asn Leu Phe Gln Val Val His Asn Ser Tyr 
385                 390                 395                 400 


Asn Arg Pro Ala Tyr Ser Pro Gly His Lys Thr His Ala Pro Thr Ser 
                405                 410                 415     


Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His Leu Leu Leu Asp 
            420                 425                 430         


Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys Asn Pro Lys Leu 
        435                 440                 445             


Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys Lys Ala Thr Glu 
    450                 455                 460                 


Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys Pro Leu Glu Glu 
465                 470                 475                 480 


Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu Arg Pro Arg Asp 
                485                 490                 495     


Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu Lys Gly Ser Glu 
            500                 505                 510         


Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala Thr Ile Val Glu 
        515                 520                 525             


Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile Ile Ser Thr Leu 
    530                 535                 540                 


Thr 
545 


<210> 15
<211> 520
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 15
Gly Ala Asp Asp Val Ala Asp Ser Ser Lys Ser Phe Val Met Glu Asn 
1               5                   10                  15      


Phe Ser Ser Tyr His Gly Thr Lys Pro Gly Tyr Val Asp Ser Ile Gln 
            20                  25                  30          


Lys Gly Ile Gln Lys Pro Lys Ser Gly Thr Gln Gly Asn Tyr Asp Asp 
        35                  40                  45              


Asp Trp Lys Gly Phe Tyr Ser Thr Asp Asn Lys Tyr Asp Ala Ala Gly 
    50                  55                  60                  


Tyr Ser Val Asp Asn Glu Asn Pro Leu Ser Gly Lys Ala Gly Gly Val 
65                  70                  75                  80  


Val Lys Val Thr Tyr Pro Gly Leu Thr Lys Val Leu Ala Leu Lys Val 
                85                  90                  95      


Asp Asn Ala Glu Thr Ile Lys Lys Glu Leu Gly Leu Ser Leu Thr Glu 
            100                 105                 110         


Pro Leu Met Glu Gln Val Gly Thr Glu Glu Phe Ile Lys Arg Phe Gly 
        115                 120                 125             


Asp Gly Ala Ser Arg Val Val Leu Ser Leu Pro Phe Ala Glu Gly Ser 
    130                 135                 140                 


Ser Ser Val Glu Tyr Ile Asn Asn Trp Glu Gln Ala Lys Ala Leu Ser 
145                 150                 155                 160 


Val Glu Leu Glu Ile Asn Phe Glu Thr Arg Gly Lys Arg Gly Gln Asp 
                165                 170                 175     


Ala Met Tyr Glu Tyr Met Ala Gln Ala Cys Ala Gly Asn Arg Val Arg 
            180                 185                 190         


Arg Ser Val Gly Ser Ser Leu Ser Cys Ile Asn Leu Asp Trp Asp Val 
        195                 200                 205             


Ile Arg Asp Lys Thr Lys Thr Lys Ile Glu Ser Leu Lys Glu His Gly 
    210                 215                 220                 


Pro Ile Lys Asn Lys Met Ser Glu Ser Pro Asn Lys Thr Val Ser Glu 
225                 230                 235                 240 


Glu Lys Ala Lys Gln Tyr Leu Glu Glu Phe His Gln Thr Ala Leu Glu 
                245                 250                 255     


His Pro Glu Leu Ser Glu Leu Lys Thr Val Thr Gly Thr Asn Pro Val 
            260                 265                 270         


Phe Ala Gly Ala Asn Tyr Ala Ala Trp Ala Val Asn Val Ala Gln Val 
        275                 280                 285             


Ile Asp Ser Glu Thr Ala Asp Asn Leu Glu Lys Thr Thr Ala Ala Leu 
    290                 295                 300                 


Ser Ile Leu Pro Gly Ile Gly Ser Val Met Gly Ile Ala Asp Gly Ala 
305                 310                 315                 320 


Val His His Asn Thr Glu Glu Ile Val Ala Gln Ser Ile Ala Leu Ser 
                325                 330                 335     


Ser Leu Met Val Ala Gln Ala Ile Pro Leu Val Gly Glu Leu Val Asp 
            340                 345                 350         


Ile Gly Phe Ala Ala Tyr Asn Phe Val Glu Ser Ile Ile Asn Leu Phe 
        355                 360                 365             


Gln Val Val His Asn Ser Tyr Asn Arg Pro Ala Tyr Ser Pro Gly His 
    370                 375                 380                 


Lys Thr His Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln 
385                 390                 395                 400 


Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn 
                405                 410                 415     


Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr 
            420                 425                 430         


Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu 
        435                 440                 445             


Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn 
    450                 455                 460                 


Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val 
465                 470                 475                 480 


Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp 
                485                 490                 495     


Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys 
            500                 505                 510         


Gln Ser Ile Ile Ser Thr Leu Thr 
        515                 520 


<210> 16
<211> 522
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 16
Met Gly Ala Asp Asp Val Ala Asp Ser Ser Lys Ser Phe Val Met Glu 
1               5                   10                  15      


Asn Phe Ser Ser Tyr His Gly Thr Lys Pro Gly Tyr Val Asp Ser Ile 
            20                  25                  30          


Gln Lys Gly Ile Gln Lys Pro Lys Ser Gly Thr Gln Gly Asn Tyr Asp 
        35                  40                  45              


Asp Asp Trp Lys Gly Phe Tyr Ser Thr Asp Asn Lys Tyr Asp Ala Ala 
    50                  55                  60                  


Gly Tyr Ser Val Asp Asn Glu Asn Pro Leu Ser Gly Lys Ala Gly Gly 
65                  70                  75                  80  


Val Val Lys Val Thr Tyr Pro Gly Leu Thr Lys Val Leu Ala Leu Lys 
                85                  90                  95      


Val Asp Asn Ala Glu Thr Ile Lys Lys Glu Leu Gly Leu Ser Leu Thr 
            100                 105                 110         


Glu Pro Leu Met Glu Gln Val Gly Thr Glu Glu Phe Ile Lys Arg Phe 
        115                 120                 125             


Gly Asp Gly Ala Ser Arg Val Val Leu Ser Leu Pro Phe Ala Glu Gly 
    130                 135                 140                 


Ser Ser Ser Val Glu Tyr Ile Asn Asn Trp Glu Gln Ala Lys Ala Leu 
145                 150                 155                 160 


Ser Val Glu Leu Glu Ile Asn Phe Glu Thr Arg Gly Lys Arg Gly Gln 
                165                 170                 175     


Asp Ala Met Tyr Glu Tyr Met Ala Gln Ala Cys Ala Gly Asn Arg Val 
            180                 185                 190         


Arg Arg Ser Val Gly Ser Ser Leu Ser Cys Ile Asn Leu Asp Trp Asp 
        195                 200                 205             


Val Ile Arg Asp Lys Thr Lys Thr Lys Ile Glu Ser Leu Lys Glu His 
    210                 215                 220                 


Gly Pro Ile Lys Asn Lys Met Ser Glu Ser Pro Asn Lys Thr Val Ser 
225                 230                 235                 240 


Glu Glu Lys Ala Lys Gln Tyr Leu Glu Glu Phe His Gln Thr Ala Leu 
                245                 250                 255     


Glu His Pro Glu Leu Ser Glu Leu Lys Thr Val Thr Gly Thr Asn Pro 
            260                 265                 270         


Val Phe Ala Gly Ala Asn Tyr Ala Ala Trp Ala Val Asn Val Ala Gln 
        275                 280                 285             


Val Ile Asp Ser Glu Thr Ala Asp Asn Leu Glu Lys Thr Thr Ala Ala 
    290                 295                 300                 


Leu Ser Ile Leu Pro Gly Ile Gly Ser Val Met Gly Ile Ala Asp Gly 
305                 310                 315                 320 


Ala Val His His Asn Thr Glu Glu Ile Val Ala Gln Ser Ile Ala Leu 
                325                 330                 335     


Ser Ser Leu Met Val Ala Gln Ala Ile Pro Leu Val Gly Glu Leu Val 
            340                 345                 350         


Asp Ile Gly Phe Ala Ala Tyr Asn Phe Val Glu Ser Ile Ile Asn Leu 
        355                 360                 365             


Phe Gln Val Val His Asn Ser Tyr Asn Arg Pro Ala Tyr Ser Pro Gly 
    370                 375                 380                 


His Lys Thr His Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu 
385                 390                 395                 400 


Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile 
                405                 410                 415     


Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe 
            420                 425                 430         


Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Leu Gln Cys Leu 
        435                 440                 445             


Glu Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser 
    450                 455                 460                 


Lys Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val 
465                 470                 475                 480 


Ile Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr 
                485                 490                 495     


Ala Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr 
            500                 505                 510         


Phe Cys Gln Ser Ile Ile Ser Thr Leu Thr 
        515                 520         


<210> 17
<211> 535
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 17
Gly Ala Asp Asp Val Val Asp Ser Ser Lys Ser Phe Val Met Glu Asn 
1               5                   10                  15      


Phe Ser Ser Tyr His Gly Thr Lys Pro Gly Tyr Val Asp Ser Ile Gln 
            20                  25                  30          


Lys Gly Ile Gln Lys Pro Lys Ser Gly Thr Gln Gly Asn Tyr Asp Asp 
        35                  40                  45              


Asp Trp Lys Glu Phe Tyr Ser Thr Asp Asn Lys Tyr Asp Ala Ala Gly 
    50                  55                  60                  


Tyr Ser Val Asp Asn Glu Asn Pro Leu Ser Gly Lys Ala Gly Gly Val 
65                  70                  75                  80  


Val Lys Val Thr Tyr Pro Gly Leu Thr Lys Val Leu Ala Leu Lys Val 
                85                  90                  95      


Asp Asn Ala Glu Thr Ile Lys Lys Glu Leu Gly Leu Ser Leu Thr Glu 
            100                 105                 110         


Pro Leu Met Glu Gln Val Gly Thr Glu Glu Phe Ile Lys Arg Phe Gly 
        115                 120                 125             


Asp Gly Ala Ser Arg Val Val Leu Ser Leu Pro Phe Ala Glu Gly Ser 
    130                 135                 140                 


Ser Ser Val Glu Tyr Ile Asn Asn Trp Glu Gln Ala Lys Ala Leu Ser 
145                 150                 155                 160 


Val Glu Leu Glu Ile Asn Phe Glu Thr Arg Gly Lys Arg Gly Gln Asp 
                165                 170                 175     


Ala Met Tyr Glu Tyr Met Ala Gln Ala Cys Ala Gly Asn Arg Val Arg 
            180                 185                 190         


Arg Ser Val Gly Ser Ser Leu Ser Cys Ile Asn Leu Asp Trp Asp Val 
        195                 200                 205             


Ile Arg Asp Lys Thr Lys Thr Lys Ile Glu Ser Leu Lys Glu His Gly 
    210                 215                 220                 


Pro Ile Lys Asn Lys Met Ser Glu Ser Pro Asn Lys Thr Val Ser Glu 
225                 230                 235                 240 


Glu Lys Ala Lys Gln Tyr Leu Glu Glu Phe His Gln Thr Ala Leu Glu 
                245                 250                 255     


His Pro Glu Leu Ser Glu Leu Lys Thr Val Thr Gly Thr Asn Pro Val 
            260                 265                 270         


Phe Ala Gly Ala Asn Tyr Ala Ala Trp Ala Val Asn Val Ala Gln Val 
        275                 280                 285             


Ile Asp Ser Glu Thr Ala Asp Asn Leu Glu Lys Thr Thr Ala Ala Leu 
    290                 295                 300                 


Ser Ile Leu Pro Gly Ile Gly Ser Val Met Gly Ile Ala Asp Gly Ala 
305                 310                 315                 320 


Val His His Asn Thr Glu Glu Ile Val Ala Gln Ser Ile Ala Leu Ser 
                325                 330                 335     


Ser Leu Met Val Ala Gln Ala Ile Pro Leu Val Gly Glu Leu Val Asp 
            340                 345                 350         


Ile Gly Phe Ala Ala Tyr Asn Phe Val Glu Ser Ile Ile Asn Leu Phe 
        355                 360                 365             


Gln Val Val His Asn Ser Tyr Asn Arg Pro Ala Tyr Ser Pro Gly His 
    370                 375                 380                 


Lys Thr Gln Pro Phe Leu His Asp Gly Tyr Ala Val Ser Trp Asn Thr 
385                 390                 395                 400 


Val Glu Asp Ser Ile Ile Arg Thr Gly Phe Gln Gly Glu Ser Gly His 
                405                 410                 415     


Asp Ile Lys Ile Thr Ala Glu Asn Thr Pro Leu Pro Ile Ala Gly Val 
            420                 425                 430         


Leu Leu Pro Thr Ile Pro Gly Lys Leu Asp Val Asn Lys Ser Lys Thr 
        435                 440                 445             


His Ile Ser Val Asn Gly Arg Lys Ile Arg Met Arg Cys Arg Ala Ile 
    450                 455                 460                 


Asp Gly Asp Val Thr Phe Cys Arg Pro Lys Ser Pro Val Tyr Val Gly 
465                 470                 475                 480 


Asn Gly Val His Ala Asn Leu His Val Ala Phe His Arg Ser Ser Ser 
                485                 490                 495     


Glu Lys Ile His Ser Asn Glu Ile Ser Ser Asp Ser Ile Gly Val Leu 
            500                 505                 510         


Gly Tyr Gln Lys Thr Val Asp His Thr Lys Val Asn Ser Lys Leu Ser 
        515                 520                 525             


Leu Phe Phe Glu Ile Lys Ser 
    530                 535 


<210> 18
<211> 560
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 18
Met Ser Arg Lys Leu Phe Ala Ser Ile Leu Ile Gly Ala Leu Leu Gly 
1               5                   10                  15      


Ile Gly Ala Pro Pro Ser Ala His Ala Gly Ala Asp Asp Val Val Asp 
            20                  25                  30          


Ser Ser Lys Ser Phe Val Met Glu Asn Phe Ser Ser Tyr His Gly Thr 
        35                  40                  45              


Lys Pro Gly Tyr Val Asp Ser Ile Gln Lys Gly Ile Gln Lys Pro Lys 
    50                  55                  60                  


Ser Gly Thr Gln Gly Asn Tyr Asp Asp Asp Trp Lys Glu Phe Tyr Ser 
65                  70                  75                  80  


Thr Asp Asn Lys Tyr Asp Ala Ala Gly Tyr Ser Val Asp Asn Glu Asn 
                85                  90                  95      


Pro Leu Ser Gly Lys Ala Gly Gly Val Val Lys Val Thr Tyr Pro Gly 
            100                 105                 110         


Leu Thr Lys Val Leu Ala Leu Lys Val Asp Asn Ala Glu Thr Ile Lys 
        115                 120                 125             


Lys Glu Leu Gly Leu Ser Leu Thr Glu Pro Leu Met Glu Gln Val Gly 
    130                 135                 140                 


Thr Glu Glu Phe Ile Lys Arg Phe Gly Asp Gly Ala Ser Arg Val Val 
145                 150                 155                 160 


Leu Ser Leu Pro Phe Ala Glu Gly Ser Ser Ser Val Glu Tyr Ile Asn 
                165                 170                 175     


Asn Trp Glu Gln Ala Lys Ala Leu Ser Val Glu Leu Glu Ile Asn Phe 
            180                 185                 190         


Glu Thr Arg Gly Lys Arg Gly Gln Asp Ala Met Tyr Glu Tyr Met Ala 
        195                 200                 205             


Gln Ala Cys Ala Gly Asn Arg Val Arg Arg Ser Val Gly Ser Ser Leu 
    210                 215                 220                 


Ser Cys Ile Asn Leu Asp Trp Asp Val Ile Arg Asp Lys Thr Lys Thr 
225                 230                 235                 240 


Lys Ile Glu Ser Leu Lys Glu His Gly Pro Ile Lys Asn Lys Met Ser 
                245                 250                 255     


Glu Ser Pro Asn Lys Thr Val Ser Glu Glu Lys Ala Lys Gln Tyr Leu 
            260                 265                 270         


Glu Glu Phe His Gln Thr Ala Leu Glu His Pro Glu Leu Ser Glu Leu 
        275                 280                 285             


Lys Thr Val Thr Gly Thr Asn Pro Val Phe Ala Gly Ala Asn Tyr Ala 
    290                 295                 300                 


Ala Trp Ala Val Asn Val Ala Gln Val Ile Asp Ser Glu Thr Ala Asp 
305                 310                 315                 320 


Asn Leu Glu Lys Thr Thr Ala Ala Leu Ser Ile Leu Pro Gly Ile Gly 
                325                 330                 335     


Ser Val Met Gly Ile Ala Asp Gly Ala Val His His Asn Thr Glu Glu 
            340                 345                 350         


Ile Val Ala Gln Ser Ile Ala Leu Ser Ser Leu Met Val Ala Gln Ala 
        355                 360                 365             


Ile Pro Leu Val Gly Glu Leu Val Asp Ile Gly Phe Ala Ala Tyr Asn 
    370                 375                 380                 


Phe Val Glu Ser Ile Ile Asn Leu Phe Gln Val Val His Asn Ser Tyr 
385                 390                 395                 400 


Asn Arg Pro Ala Tyr Ser Pro Gly His Lys Thr Gln Pro Phe Leu His 
                405                 410                 415     


Asp Gly Tyr Ala Val Ser Trp Asn Thr Val Glu Asp Ser Ile Ile Arg 
            420                 425                 430         


Thr Gly Phe Gln Gly Glu Ser Gly His Asp Ile Lys Ile Thr Ala Glu 
        435                 440                 445             


Asn Thr Pro Leu Pro Ile Ala Gly Val Leu Leu Pro Thr Ile Pro Gly 
    450                 455                 460                 


Lys Leu Asp Val Asn Lys Ser Lys Thr His Ile Ser Val Asn Gly Arg 
465                 470                 475                 480 


Lys Ile Arg Met Arg Cys Arg Ala Ile Asp Gly Asp Val Thr Phe Cys 
                485                 490                 495     


Arg Pro Lys Ser Pro Val Tyr Val Gly Asn Gly Val His Ala Asn Leu 
            500                 505                 510         


His Val Ala Phe His Arg Ser Ser Ser Glu Lys Ile His Ser Asn Glu 
        515                 520                 525             


Ile Ser Ser Asp Ser Ile Gly Val Leu Gly Tyr Gln Lys Thr Val Asp 
    530                 535                 540                 


His Thr Lys Val Asn Ser Lys Leu Ser Leu Phe Phe Glu Ile Lys Ser 
545                 550                 555                 560 


<210> 19
<211> 535
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 19
Gly Ala Asp Asp Val Val Asp Ser Ser Lys Ser Phe Val Met Glu Asn 
1               5                   10                  15      


Phe Ser Ser Tyr His Gly Thr Lys Pro Gly Tyr Val Asp Ser Ile Gln 
            20                  25                  30          


Lys Gly Ile Gln Lys Pro Lys Ser Gly Thr Gln Gly Asn Tyr Asp Asp 
        35                  40                  45              


Asp Trp Lys Gly Phe Tyr Ser Thr Asp Asn Lys Tyr Asp Ala Ala Gly 
    50                  55                  60                  


Tyr Ser Val Asp Asn Glu Asn Pro Leu Ser Gly Lys Ala Gly Gly Val 
65                  70                  75                  80  


Val Lys Val Thr Tyr Pro Gly Leu Thr Lys Val Leu Ala Leu Lys Val 
                85                  90                  95      


Asp Asn Ala Glu Thr Ile Lys Lys Glu Leu Gly Leu Ser Leu Thr Glu 
            100                 105                 110         


Pro Leu Met Glu Gln Val Gly Thr Glu Glu Phe Ile Lys Arg Phe Gly 
        115                 120                 125             


Asp Gly Ala Ser Arg Val Val Leu Ser Leu Pro Phe Ala Glu Gly Ser 
    130                 135                 140                 


Ser Ser Val Glu Tyr Ile Asn Asn Trp Glu Gln Ala Lys Ala Leu Ser 
145                 150                 155                 160 


Val Glu Leu Glu Ile Asn Phe Glu Thr Arg Gly Lys Arg Gly Gln Asp 
                165                 170                 175     


Ala Met Tyr Glu Tyr Met Ala Gln Ala Cys Ala Gly Asn Arg Val Arg 
            180                 185                 190         


Arg Ser Val Gly Ser Ser Leu Ser Cys Ile Asn Leu Asp Trp Asp Val 
        195                 200                 205             


Ile Arg Asp Lys Thr Lys Thr Lys Ile Glu Ser Leu Lys Glu His Gly 
    210                 215                 220                 


Pro Ile Lys Asn Lys Met Ser Glu Ser Pro Asn Lys Thr Val Ser Glu 
225                 230                 235                 240 


Glu Lys Ala Lys Gln Tyr Leu Glu Glu Phe His Gln Thr Ala Leu Glu 
                245                 250                 255     


His Pro Glu Leu Ser Glu Leu Lys Thr Val Thr Gly Thr Asn Pro Val 
            260                 265                 270         


Phe Ala Gly Ala Asn Tyr Ala Ala Trp Ala Val Asn Val Ala Gln Val 
        275                 280                 285             


Ile Asp Ser Glu Thr Ala Asp Asn Leu Glu Lys Thr Thr Ala Ala Leu 
    290                 295                 300                 


Ser Ile Leu Pro Gly Ile Gly Ser Val Met Gly Ile Ala Asp Gly Ala 
305                 310                 315                 320 


Val His His Asn Thr Glu Glu Ile Val Ala Gln Ser Ile Ala Leu Ser 
                325                 330                 335     


Ser Leu Met Val Ala Gln Ala Ile Pro Leu Val Gly Glu Leu Val Asp 
            340                 345                 350         


Ile Gly Phe Ala Ala Tyr Asn Phe Val Glu Ser Ile Ile Asn Leu Phe 
        355                 360                 365             


Gln Val Val His Asn Ser Tyr Asn Arg Pro Ala Tyr Ser Pro Gly His 
    370                 375                 380                 


Lys Thr Gln Pro Phe Phe His Asp Gly Tyr Ala Val Ser Trp Asn Thr 
385                 390                 395                 400 


Val Glu Asp Ser Ile Ile Arg Thr Gly Phe Gln Gly Glu Ser Gly His 
                405                 410                 415     


Asp Ile Lys Ile Thr Ala Glu Asn Thr Pro Leu Pro Ile Ala Gly Val 
            420                 425                 430         


Leu Leu Pro Thr Ile Pro Gly Lys Leu Asp Val Asn Lys Ser Lys Thr 
        435                 440                 445             


His Ile Ser Val Asn Gly Arg Lys Ile Arg Met Arg Cys Arg Ala Ile 
    450                 455                 460                 


Asp Gly Asp Val Thr Phe Cys Arg Pro Lys Ser Pro Val Tyr Val Gly 
465                 470                 475                 480 


Asn Gly Val His Ala Asn Leu His Val Ala Phe His Arg Ser Ser Ser 
                485                 490                 495     


Glu Lys Ile His Ser Asn Glu Ile Ser Ser Asp Ser Ile Gly Val Leu 
            500                 505                 510         


Gly Tyr Gln Lys Thr Val Asp His Thr Lys Val Asn Phe Lys Leu Ser 
        515                 520                 525             


Leu Phe Phe Glu Ile Lys Ser 
    530                 535 


<210> 20
<211> 560
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 20
Met Ser Arg Lys Leu Phe Ala Ser Ile Leu Ile Gly Ala Leu Leu Gly 
1               5                   10                  15      


Ile Gly Ala Pro Pro Ser Ala His Ala Gly Ala Asp Asp Val Val Asp 
            20                  25                  30          


Ser Ser Lys Ser Phe Val Met Glu Asn Phe Ser Ser Tyr His Gly Thr 
        35                  40                  45              


Lys Pro Gly Tyr Val Asp Ser Ile Gln Lys Gly Ile Gln Lys Pro Lys 
    50                  55                  60                  


Ser Gly Thr Gln Gly Asn Tyr Asp Asp Asp Trp Lys Gly Phe Tyr Ser 
65                  70                  75                  80  


Thr Asp Asn Lys Tyr Asp Ala Ala Gly Tyr Ser Val Asp Asn Glu Asn 
                85                  90                  95      


Pro Leu Ser Gly Lys Ala Gly Gly Val Val Lys Val Thr Tyr Pro Gly 
            100                 105                 110         


Leu Thr Lys Val Leu Ala Leu Lys Val Asp Asn Ala Glu Thr Ile Lys 
        115                 120                 125             


Lys Glu Leu Gly Leu Ser Leu Thr Glu Pro Leu Met Glu Gln Val Gly 
    130                 135                 140                 


Thr Glu Glu Phe Ile Lys Arg Phe Gly Asp Gly Ala Ser Arg Val Val 
145                 150                 155                 160 


Leu Ser Leu Pro Phe Ala Glu Gly Ser Ser Ser Val Glu Tyr Ile Asn 
                165                 170                 175     


Asn Trp Glu Gln Ala Lys Ala Leu Ser Val Glu Leu Glu Ile Asn Phe 
            180                 185                 190         


Glu Thr Arg Gly Lys Arg Gly Gln Asp Ala Met Tyr Glu Tyr Met Ala 
        195                 200                 205             


Gln Ala Cys Ala Gly Asn Arg Val Arg Arg Ser Val Gly Ser Ser Leu 
    210                 215                 220                 


Ser Cys Ile Asn Leu Asp Trp Asp Val Ile Arg Asp Lys Thr Lys Thr 
225                 230                 235                 240 


Lys Ile Glu Ser Leu Lys Glu His Gly Pro Ile Lys Asn Lys Met Ser 
                245                 250                 255     


Glu Ser Pro Asn Lys Thr Val Ser Glu Glu Lys Ala Lys Gln Tyr Leu 
            260                 265                 270         


Glu Glu Phe His Gln Thr Ala Leu Glu His Pro Glu Leu Ser Glu Leu 
        275                 280                 285             


Lys Thr Val Thr Gly Thr Asn Pro Val Phe Ala Gly Ala Asn Tyr Ala 
    290                 295                 300                 


Ala Trp Ala Val Asn Val Ala Gln Val Ile Asp Ser Glu Thr Ala Asp 
305                 310                 315                 320 


Asn Leu Glu Lys Thr Thr Ala Ala Leu Ser Ile Leu Pro Gly Ile Gly 
                325                 330                 335     


Ser Val Met Gly Ile Ala Asp Gly Ala Val His His Asn Thr Glu Glu 
            340                 345                 350         


Ile Val Ala Gln Ser Ile Ala Leu Ser Ser Leu Met Val Ala Gln Ala 
        355                 360                 365             


Ile Pro Leu Val Gly Glu Leu Val Asp Ile Gly Phe Ala Ala Tyr Asn 
    370                 375                 380                 


Phe Val Glu Ser Ile Ile Asn Leu Phe Gln Val Val His Asn Ser Tyr 
385                 390                 395                 400 


Asn Arg Pro Ala Tyr Ser Pro Gly His Lys Thr Gln Pro Phe Phe His 
                405                 410                 415     


Asp Gly Tyr Ala Val Ser Trp Asn Thr Val Glu Asp Ser Ile Ile Arg 
            420                 425                 430         


Thr Gly Phe Gln Gly Glu Ser Gly His Asp Ile Lys Ile Thr Ala Glu 
        435                 440                 445             


Asn Thr Pro Leu Pro Ile Ala Gly Val Leu Leu Pro Thr Ile Pro Gly 
    450                 455                 460                 


Lys Leu Asp Val Asn Lys Ser Lys Thr His Ile Ser Val Asn Gly Arg 
465                 470                 475                 480 


Lys Ile Arg Met Arg Cys Arg Ala Ile Asp Gly Asp Val Thr Phe Cys 
                485                 490                 495     


Arg Pro Lys Ser Pro Val Tyr Val Gly Asn Gly Val His Ala Asn Leu 
            500                 505                 510         


His Val Ala Phe His Arg Ser Ser Ser Glu Lys Ile His Ser Asn Glu 
        515                 520                 525             


Ile Ser Ser Asp Ser Ile Gly Val Leu Gly Tyr Gln Lys Thr Val Asp 
    530                 535                 540                 


His Thr Lys Val Asn Phe Lys Leu Ser Leu Phe Phe Glu Ile Lys Ser 
545                 550                 555                 560 


<210> 21
<211> 6402
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 21
ggcgagtgct ttgaatgctt gggcttcttc acggcgggtc ttgaccgcgt tgataagttc       60

gcggccagag ctgaattgct ggcgtggggt ggggttgaac tggtcgtgtc ctgccatatc      120

ccttacctgc tttatcaagt ctccaaggcg catcacccgg ttgtgctgcc tataccaacg      180

ataagcggta ggggctttgc ctgtgtagaa cgggttgcgg ctaaagcggt gggaaaagtg      240

cgggtcatgg tctaaaagct cacccagcac acgcgtggtt gctgcaagaa gcttcatctg      300

cgcagattta ccgttacggt cagcgtagac agggtcaata agccatatga actgggcttt      360

gccgttagtt gggttaatac ccacccaggc tggcccgacg ctatgagtaa tcagtgagcg      420

caccacgtcg cggacgtacg ggtttaagtc tgcggggtca ccgcctgcgg tacctacttg      480

gtcaacgtct acgaccagga cggcggcgta ctgcttggtg gtgagcatgg cgtactcgca      540

ccgtcctaaa gcatcagtct cgaagcgata catacgcggc gagttcgtgc cgtcagcgtt      600

gcgtcgatag gcctttttaa agtctcgtgt gactgaaccg tggagtacat cgcggcctag      660

atgatcgcgt aaaaggtcgc ggtcactggc agatgctggg gtgttgtcca gtccaccacg      720

gtcgcgctcg acgcgggtag gtgttttagt gtgcgcattc tgcgcatgag tctgtaaact      780

catgaccgtg ctttctccca ggtgtgtgct gggtgataag cgaaagtcat cgggttgccg      840

cccggtggct ttcttcgttt ttcattgtct ttccctgact ctaaatgaca ccggtgttat      900

ttactagcca tgacacgcga aaaatatgcc ttttacctgc ggttacgtat ggctagacat      960

atggcaagct atacgtaacc gcgtttcagc tgcacagggc tgtctgcgca gatttaccat     1020

cacgggactt ttcccagttc aggctgcgca tatttacgca tacaacgaaa gcggttgcgc     1080

agatttacca cacactctgc gctgatttac cgatacgcag aaaaagcgtg cgcagattta     1140

cccatacggt ggcgaattat ccagagcaat aggtatacag caatacagta atacaggtgc     1200

cataaacctg tattactgta ttgctgtatg cctgtaaacc tttatttatt gttgtggacg     1260

tattcttcga ggtaggtgct aacaatctcg cggatggtca cgcctttttg ggcggcgatg     1320

actttaagtt ctgcgtgaag gtcgcggtcg atttcaatcg tcatcttctt gacgtagtcg     1380

cggcctgtgg gttggtggaa tgcgcttcgc actgttttct tctcggctgc tggagttagc     1440

ttcgtggctt ttttcattga ggttcgcggg ccttgctgcg ccctggcgcg ttctttactg     1500

gtgctcattt catcatctcc atgagttcgt cggcgacgtg gtcgtagccg tgcatgtcgg     1560

ggcctgggca gtatccaaac gctaggtgca tatcttcgcg tagcgggatt tcggttttaa     1620

agtgcggcat gtgttccgcg tcgagcgctt ctcgtgccgc gtcaagggcg ctggtgcctt     1680

tcctggcgaa cgtcagtaag actgcatgag gtgttccgtt gactgcgtcg cgcagctccc     1740

atactcggga gaggtcggca gcagcagaac gggtcggaag aatgatgaag tcgctgactg     1800

cgattgctgc ttcgatagcg ttctcgtctc ctggcggcac atcgataccg actgggcgat     1860

ggcccactac gtgaaccatc accctaatca agttttttgg ggtcgaggtg ccgtaaagca     1920

ctaaatcgga accctaaagg gagcccccga tttagagctt gacggggaaa gccggcgaac     1980

gtggcgagaa aggaagggaa gaaagcgaaa ggagcgggcg ctagggcgct ggcaagtgta     2040

gcggtcacgc tgcgcgtaac caccacaccc gccgcgctta atgcgccgct acagggcgct     2100

cccattcgcc attcaggctg cgcaactgtt gggaagggcg atcggtgcgg gcctcttcgc     2160

tattacgcca gctggcgaaa gggggatgtg ctgcaaggcg attaagttgg gtaacgccag     2220

ggttttccca gtcacgacgt tgtaaaacga cggccagtga attgtaatac gactcactat     2280

agggcgaatt ggagctccac cgcggtggcg gccgctctag aactagtgga tccagggcat     2340

tgatttcaga gcacccttat aattaggata gctaagtcca ttattttatg agtcctggta     2400

aggggatacg ttgtgagcag aaaactgttt gcgtcaatct taataggggc gctactgggg     2460

ataggggccc caccttcagc ccatgcaggc gctgatgatg ttgttgattc ttctaaatct     2520

tttgtgatgg aaaacttttc ttcgtaccac gggactaaac ctggttatgt agattccatt     2580

caaaaaggta tacaaaagcc aaaatctggt acacaaggaa attatgacga tgattggaaa     2640

gggttttata gtaccgacaa taaatacgac gctgcgggat actctgtaga taatgaaaac     2700

ccgctctctg gaaaagctgg aggcgtggtc aaagtgacgt atccaggact gacgaaggtt     2760

ctcgcactaa aagtggataa tgccgaaact attaagaaag agttaggttt aagtctcact     2820

gaaccgttga tggagcaagt cggaacggaa gagtttatca aaaggttcgg tgatggtgct     2880

tcgcgtgtag tgctcagcct tcccttcgct gaggggagtt ctagcgttga atatattaat     2940

aactgggaac aggcgaaagc gttaagcgta gaacttgaga ttaattttga aacccgtgga     3000

aaacgtggcc aagatgcgat gtatgagtat atggctcaag cctgtgcagg aaatcgtgtc     3060

aggcgatcag taggtagctc attgtcatgc atcaacctgg attgggatgt tatccgtgat     3120

aaaactaaaa ctaagatcga atctctgaaa gaacacggtc cgatcaaaaa caaaatgagc     3180

gaaagcccga acaaaactgt atctgaagaa aaagctaaac agtacctgga agaattccac     3240

cagactgcac tggaacaccc ggaactgtct gaacttaaga ccgttactgg taccaacccg     3300

gtattcgctg gtgctaacta cgctgcttgg gcagtaaacg ttgctcaggt tatcgatagc     3360

gaaactgctg ataacctgga aaaaactacc gcggctctgt ctatcctgcc gggtatcggt     3420

agcgtaatgg gcatcgcaga cggcgccgtt caccacaaca ctgaagaaat cgttgcacag     3480

tctatcgctc tgagctctct gatggttgct caggccatcc cgctggtagg tgaactggtt     3540

gatatcggtt tcgctgcata caacttcgtt gaaagcatca tcaacctgtt ccaggttgtt     3600

cacaactctt acaaccgccc ggcttactct ccgggtcaca agacgcatgc acctacttct     3660

agctctacca agaaaaccca gctgcagctc gagcacctgc tgctggattt gcagatgatc     3720

ctgaacggta tcaacaatta caagaacccg aaactgacgc gtatgctgac cttcaagttc     3780

tacatgccga agaaggccac cgaactgaaa cacctgcagt gtctagaaga agaactgaaa     3840

ccgctggagg aagttctgaa cctggctcag tctaaaaact tccacctgcg gccgcgtgac     3900

ctgatctcta acatcaacgt aatcgttctg gaactgaagg gctctgaaac caccttcatg     3960

tgtgaatacg ctgatgagac cgcaaccatc gtagaattcc tgaaccgttg gatcaccttc     4020

tgtcagtcta tcatctctac cctgacctga ggatcccccg ggctgcagga attcgatatc     4080

aagcttatcg ataccgtcga cctcgagggg gggcccggta ccagcttttg ttccctttag     4140

tgagggttaa tttcgagctt ggcgtaatca tggtcatagc tgtttcctgt gtgaaattgt     4200

tatccgctca caattccaca caacatacga gccggaagca taaagtgtaa agcctggggt     4260

gcctaatgag tgagtccccg atccgtcgag ctcgacctgc aggggggggg gggcgctgag     4320

gtctgcctcg tgaagaaggt gttgctgact cataccaggc ctgaatcgcc ccatcatcca     4380

gccagaaagt gagggagcca cggttgatga gagctttgtt gtaggtggac cagttggtga     4440

ttttgaactt ttgctttgcc acggaacggt ctgcgttgtc gggaagatgc gtgatctgat     4500

ccttcaactc agcaaaagtt cgatttattc aacaaagccg ccgtcccgtc aagtcagcgt     4560

aatgctctgc cagtgttaca accaattaac caattctgat tagaaaaact catcgagcat     4620

caaatgaaac tgcaatttat tcatatcagg attatcaata ccatattttt gaaaaagccg     4680

tttctgtaat gaaggagaaa actcaccgag gcagttccat aggatggcaa gatcctggta     4740

tcggtctgcg attccgactc gtccaacatc aatacaacct attaatttcc cctcgtcaaa     4800

aataaggtta tcaagtgaga aatcaccatg agtgacgact gaatccggtg agaatggcaa     4860

aagcttatgc atttctttcc agacttgttc aacaggccag ccattacgct cgtcatcaaa     4920

atcactcgca tcaaccaaac cgttattcat tcgtgattgc gcctgagcga gacgaaatac     4980

gcgatcgctg ttaaaaggac aattacaaac aggaatcgaa tgcaaccggc gcaggaacac     5040

tgccagcgca tcaacaatat tttcacctga atcaggatat tcttctaata cctggaatgc     5100

tgttttcccg gggatcgcag tggtgagtaa ccatgcatca tcaggagtac ggataaaatg     5160

cttgatggtc ggaagaggca taaattccgt cagccagttt agtctgacca tctcatctgt     5220

aacatcattg gcaacgctac ctttgccatg tttcagaaac aactctggcg catcgggctt     5280

cccatacaat cgatagattg tcgcacctga ttgcccgaca ttatcgcgag cccatttata     5340

cccatataaa tcagcatcca tgttggaatt taatcgcggc ctcgagcaag acgtttcccg     5400

ttgaatatgg ctcataacac cccttgtatt actgtttatg taagcagaca gttttattgt     5460

tcatgatgat atatttttat cttgtgcaat gtaacatcag agattttgag acacaacgtg     5520

gctttccccc ccccccctgc aggtcgagct cgacggatcg ggctgcagga attcggtgag     5580

gttatggcgg agggttgcga ggtctaggag aacagaggaa gtcatgcttt gaagcatata     5640

agctgccctg cccctcaagg ttttcttcaa gtgaggtttt atctaactgc ctaacggcag     5700

gggaaccgta tattgcttac ggtatgagac cccttaaacg tccggatagt caccgctctt     5760

ctttagctcc gcgacatgcc tagcaaccgt ggcgcgagag actcctacct ctgcccctat     5820

ttcagcccac gtgggaactg tccctgtctg gaaatactga tcgttcacca tttggctaat     5880

acgggacttc gtagatcgtc cttgagcctt tttcttacgg tgcgtctttt caagcttcga     5940

cctttgtgct tgcgcatatt tgccctcggg gtctgttttc cagcgttgtg cggctttttg     6000

tccgcctctg cgtcccatcg tggccaaggc tttccgctcg ctgctggtgg ctttacctgg     6060

tgcgttagag ccgctgtagg tctcgctctt ggattgggcg acatacccgc gcacgcgcct     6120

tgccatggtt tggcggtcgc gcatgggtgg catctcgttg tcgcggcctg caccgccgtg     6180

ggtgtgtgcg acgttgtagg cgtgctcata ggcgtcgatg attgctgcgt ctgtcaggcg     6240

ttggccttgc tggcgcaagc ggtggccagt cttaagcgca tgtctaaagg ctgtttcgtc     6300

gcgtgctgcg gttccttgga caatccagag cacacgcaca ccgtcgataa gttccgggtc     6360

atactggtcg agaccaccgg cgatttccgc gtctacgtcc tg                        6402


<210> 22
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 22
Met Ser Arg Lys Leu Phe Ala Ser Ile Leu Ile Gly Ala Leu Leu Gly 
1               5                   10                  15      


Ile Gly Ala Pro Pro Ser Ala His Ala 
            20                  25  


<210> 23
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      6xHis tag

<400> 23
His His His His His His 
1               5       


<210> 24
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 24
Asp Tyr Lys Asp Asp Asp Asp Lys 
1               5               


<210> 25
<211> 19
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      wild-type toxO sequence

<400> 25
ttaggatagc tttacctaa                                                    19


<210> 26
<211> 32
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 26
Met Gly Ala Asp Asp Val Val Asp Ser Ser Lys Ser Phe Val Met Glu 
1               5                   10                  15      


Asn Phe Ser Ser Tyr His Gly Thr Lys Pro Gly Tyr Val Asp Ser Ile 
            20                  25                  30          


<210> 27
<211> 31
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 27
Met Ser Arg Lys Leu Phe Ala Ser Ile Leu Ile Gly Ala Leu Leu Gly 
1               5                   10                  15      


Ile Gly Ala Pro Pro Ser Ala His Ala Gly Ala Asp Asp Val Val 
            20                  25                  30      


<210> 28
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 28
Met Gly Ala Asp Asp 
1               5   


<210> 29
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 29
Gly Ala Asp Asp 
1              


<210> 30
<211> 526
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 30
Gly Ala Asp Asp Val Ala Asp Ser Ser Lys Ser Phe Val Met Glu Asn 
1               5                   10                  15      


Phe Ser Ser Tyr His Gly Thr Lys Pro Gly Tyr Val Asp Ser Ile Gln 
            20                  25                  30          


Lys Gly Ile Gln Lys Pro Lys Ser Gly Thr Gln Gly Asn Tyr Asp Asp 
        35                  40                  45              


Asp Trp Lys Gly Phe Tyr Ser Thr Asp Asn Lys Tyr Asp Ala Ala Gly 
    50                  55                  60                  


Tyr Ser Val Asp Asn Glu Asn Pro Leu Ser Gly Lys Ala Gly Gly Val 
65                  70                  75                  80  


Val Lys Val Thr Tyr Pro Gly Leu Thr Lys Val Leu Ala Leu Lys Val 
                85                  90                  95      


Asp Asn Ala Glu Thr Ile Lys Lys Glu Leu Gly Leu Ser Leu Thr Glu 
            100                 105                 110         


Pro Leu Met Glu Gln Val Gly Thr Glu Glu Phe Ile Lys Arg Phe Gly 
        115                 120                 125             


Asp Gly Ala Ser Arg Val Val Leu Ser Leu Pro Phe Ala Glu Gly Ser 
    130                 135                 140                 


Ser Ser Val Glu Tyr Ile Asn Asn Trp Glu Gln Ala Lys Ala Leu Ser 
145                 150                 155                 160 


Val Glu Leu Glu Ile Asn Phe Glu Thr Arg Gly Lys Arg Gly Gln Asp 
                165                 170                 175     


Ala Met Tyr Glu Tyr Met Ala Gln Ala Cys Ala Gly Asn Arg Val Arg 
            180                 185                 190         


Arg Ser Val Gly Ser Ser Leu Ser Cys Ile Asn Leu Asp Trp Asp Val 
        195                 200                 205             


Ile Arg Asp Lys Thr Lys Thr Lys Ile Glu Ser Leu Lys Glu His Gly 
    210                 215                 220                 


Pro Ile Lys Asn Lys Met Ser Glu Ser Pro Asn Lys Thr Val Ser Glu 
225                 230                 235                 240 


Glu Lys Ala Lys Gln Tyr Leu Glu Glu Phe His Gln Thr Ala Leu Glu 
                245                 250                 255     


His Pro Glu Leu Ser Glu Leu Lys Thr Val Thr Gly Thr Asn Pro Val 
            260                 265                 270         


Phe Ala Gly Ala Asn Tyr Ala Ala Trp Ala Val Asn Val Ala Gln Val 
        275                 280                 285             


Ile Asp Ser Glu Thr Ala Asp Asn Leu Glu Lys Thr Thr Ala Ala Leu 
    290                 295                 300                 


Ser Ile Leu Pro Gly Ile Gly Ser Val Met Gly Ile Ala Asp Gly Ala 
305                 310                 315                 320 


Val His His Asn Thr Glu Glu Ile Val Ala Gln Ser Ile Ala Leu Ser 
                325                 330                 335     


Ser Leu Met Val Ala Gln Ala Ile Pro Leu Val Gly Glu Leu Val Asp 
            340                 345                 350         


Ile Gly Phe Ala Ala Tyr Asn Phe Val Glu Ser Ile Ile Asn Leu Phe 
        355                 360                 365             


Gln Val Val His Asn Ser Tyr Asn Arg Pro Ala Tyr Ser Pro Gly His 
    370                 375                 380                 


Lys Thr His Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln 
385                 390                 395                 400 


Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn 
                405                 410                 415     


Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr 
            420                 425                 430         


Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu 
        435                 440                 445             


Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn 
    450                 455                 460                 


Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val 
465                 470                 475                 480 


Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp 
                485                 490                 495     


Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys 
            500                 505                 510         


Gln Ser Ile Ile Ser Thr Leu Thr Glu Asn Leu Tyr Phe Gln 
        515                 520                 525     


<210> 31
<211> 1686
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 31
gtgagcagaa aactgtttgc gtcaatctta ataggggcgc tactggggat aggggcccca       60

ccttcagccc atgcaggcgc tgatgatgtt gctgattctt ctaaatcttt tgtgatggaa      120

aacttttctt cgtaccacgg gactaaacct ggttatgtag attccattca aaaaggtata      180

caaaagccaa aatctggtac acaaggaaat tatgacgatg attggaaagg gttttatagt      240

accgacaata aatacgacgc tgcgggatac tctgtagata atgaaaaccc gctctctgga      300

aaagctggag gcgtggtcaa agtgacgtat ccaggactga cgaaggttct cgcactaaaa      360

gtggataatg ccgaaactat taagaaagag ttaggtttaa gtctcactga accgttgatg      420

gagcaagtcg gaacggaaga gtttatcaaa aggttcggtg atggtgcttc gcgtgtagtg      480

ctcagccttc ccttcgctga ggggagttct agcgttgaat atattaataa ctgggaacag      540

gcgaaagcgt taagcgtaga acttgagatt aattttgaaa cccgtggaaa acgtggccaa      600

gatgcgatgt atgagtatat ggctcaagcc tgtgcaggaa atcgtgtcag gcgatcagta      660

ggtagctcat tgtcatgcat caacctggat tgggatgtta tccgtgataa aactaaaact      720

aagatcgaat ctctgaaaga acacggtccg atcaaaaaca aaatgagcga aagcccgaac      780

aaaactgtat ctgaagaaaa agctaaacag tacctggaag aattccacca gactgcactg      840

gaacacccgg aactgtctga acttaagacc gttactggta ccaacccggt attcgctggt      900

gctaactacg ctgcttgggc agtaaacgtt gctcaggtta tcgatagcga aactgctgat      960

aacctggaaa aaactaccgc ggctctgtct atcctgccgg gtatcggtag cgtaatgggc     1020

atcgcagacg gcgccgttca ccacaacact gaagaaatcg ttgcacagtc tatcgctctg     1080

agctctctga tggttgctca ggccatcccg ctggtaggtg aactggttga tatcggtttc     1140

gctgcataca acttcgttga aagcatcatc aacctgttcc aggttgttca caactcttac     1200

aaccgcccgg cttactctcc gggtcacaag acgcatgcac ctacttctag ctctaccaag     1260

aaaacccagc tgcagctcga gcacctgctg ctggatttgc agatgatcct gaacggtatc     1320

aacaattaca agaacccgaa actgacgcgt atgctgacct tcaagttcta catgccgaag     1380

aaggccaccg aactgaaaca cctgcagtgt ctagaagaag aactgaaacc gctggaggaa     1440

gttctgaacc tggctcagtc taaaaacttc cacctgcggc cgcgtgacct gatctctaac     1500

atcaacgtaa tcgttctgga actgaagggc tctgaaacca ccttcatgtg tgaatacgct     1560

gatgagaccg caaccatcgt agaattcctg aaccgttgga tcaccttctg tcagtctatc     1620

atctctaccc tgaccgagaa cctgtacttc cagggccatc accaccacca ccaccatcat     1680

cactag                                                                1686


<210> 32
<211> 250
<212> PRT
<213> Corynebacterium diphtheriae

<400> 32
Met Arg Lys Ile Val Thr Leu Ala Ala Ala Ser Leu Leu Gly Ile Ala 
1               5                   10                  15      


Gly Thr Ser Gly Val Leu Gly Ala Ala Thr Ala Thr Ala Leu Thr Asn 
            20                  25                  30          


Gly Thr Pro Val Ser Pro Glu Asp Asp Thr Ala Ala Glu Gly Val Val 
        35                  40                  45              


Gln Val Ala Ser Cys Thr Gly Thr Val Val Ala Ser Gln Trp Val Leu 
    50                  55                  60                  


Thr Ala Gln His Cys Val Glu Val Pro Asn Leu Gln Arg Pro Val Tyr 
65                  70                  75                  80  


Val Gly Thr Thr Arg Glu Gln Gln Gln Arg Glu Glu Asn Thr Phe Thr 
                85                  90                  95      


Ser Asp Tyr Ala Val Trp Ala Pro His Gly Asp Val Ala Leu Val His 
            100                 105                 110         


Val Thr Asp Ala Leu Pro Gln Arg Leu Val Arg Ala Val Arg Arg Ala 
        115                 120                 125             


Pro Val Ser Phe Gly Glu Gln Gly Arg Val Tyr Gly Trp Gly Ala Gly 
    130                 135                 140                 


Thr Gly Glu Thr Leu Gln Tyr Ala Arg Ala Ala Val Gly Lys Thr Ser 
145                 150                 155                 160 


Ser Gly Val Arg Pro Gln Gly Asn Gln His Gly Ala Phe Ile Val Gln 
                165                 170                 175     


Tyr Leu Asp Glu Ala Lys Ala Gly Arg Gly Asp Ser Gly Gly Pro Leu 
            180                 185                 190         


Phe Val Asn Gly Glu Val Ala Gly Val Thr Ser Phe Lys Ala Pro Gln 
        195                 200                 205             


Gly Gly Gly Arg Phe Ser Leu Phe Ala Ser Leu His Gly Leu Gly Asp 
    210                 215                 220                 


Trp Ile Ala Gln Thr Thr Ala Ala Lys Pro Glu Asn Pro Asn Ser Lys 
225                 230                 235                 240 


Asn Gln Gln Ser Gln Gln Pro Arg Arg Pro 
                245                 250 


<210> 33
<211> 753
<212> DNA
<213> Corynebacterium diphtheriae

<400> 33
atgcggaaaa ttgttactct tgctgcagca agcttgctgg gtattgcggg taccagcggt       60

gttcttggtg cggcaacagc caccgcactg acaaatggca cgcccgtctc ccctgaggac      120

gataccgctg ccgaaggcgt ggttcaagtg gctagttgta ctggcaccgt ggttgcttct      180

cagtgggtgc tgaccgccca gcattgcgtc gaggtgccca atttgcagcg gccggtctat      240

gttggcacca cccgcgagca gcaacaacgg gaagaaaata cgttcacctc ggattacgca      300

gtgtgggcac cgcacggcga tgtggcgttg gtgcatgtca ccgatgcgct gccgcagcgt      360

ctggtccgcg cggttcgccg cgcaccggtg agctttggtg agcagggacg cgtgtacggc      420

tggggtgctg gcaccggcga gacgctgcag tatgcccgcg ctgcggttgg taaaacttct      480

tccggagttc ggccgcaggg caaccagcat ggtgcattca tcgtgcagta tttggacgag      540

gctaaagccg ggcgtggcga ttccggcggg ccgctttttg tcaacggtga ggttgctggg      600

gtgacctcgt ttaaggctcc tcaaggtggt gggcgtttct cgctgtttgc ttcgctgcat      660

gggctaggcg attggattgc gcagaccacc gccgccaagc ccgagaaccc gaattccaag      720

aatcaacagt cccagcaacc acgtagaccg tag                                   753


<210> 34
<211> 1012
<212> DNA
<213> Corynebacterium diphtheriae

<400> 34
ggatccgcaa ttgcgggaat cgtcgtgctt tttagccgaa attttcttgc agccagcgct       60

atgcttatcg cctcagggtt agccgctgac atttaccgct tgaggaataa tatgagtgga      120

aatcaacggt aatttcagaa gacttgccta cacctttagc tagcgaccac cattggtggt      180

cgctagcttt ttgatggctt aagggacatt tgggcatccg tgtatcgcac attagtcata      240

caggaaatcc tccaagattt cgtccgcatg cccgaccaga cactacagca cccacatagc      300

ttctcgattg tcttgcggag cgggagtagg tagctcacgt gctaccgcac ggggaaccgt      360

atattgctta tggtgtgccc attacccacc gttggtgcta tgatccgaac ggaaaaagtc      420

agtcgtatta gtgaatcacc gttccgccgc gcgagaacgc agggctccaa caagcgtgtg      480

gttccacaag attgcaagga tgtgtacggt gctggtggcg gtggctccag cctgggtctg      540

tcgtcttctt agcaagtctg cattcacggt tccctaggca atctttgagc aaatccctgt      600

ttaacgcccc tgtacgttcg gcgccgcaga aacctgccgg atcgtgatgt taatcctgcc      660

ttgttccagc ccgcagccgt cgggaagcgt ggcatcattc acgcgcacca ccccgtgata      720

agcaaaacgc ttcggcccac cgaaaaccac caagtcgccg gagcacagag tcacatcgtc      780

ccagggttgg gtgcgtgatt cggtgtgtcc catccgaaac agtgcttcgt cgccaatcga      840

tactgaaatg accggcgccc gcgattcctc aaattcatcg acgtgcatgc ccatcccgga      900

acccggcgga tagtagttga ccagcaccat ctctgtcacg aaggcctcta cccacggggc      960

tagttcttcg gcaacctccg ctgctgcgcg caacgctgcc ggcgccggat cc             1012


<210> 35
<211> 242
<212> PRT
<213> Corynebacterium diphtheriae

<400> 35
Met Lys Lys Leu Arg Thr Leu Ala Val Thr Leu Thr Ala Ile Ala Ala 
1               5                   10                  15      


Ser Thr Met Ala Thr Met Pro Ala Gln Ala Val Ile Ser Pro Thr Pro 
            20                  25                  30          


Ser His Gln Val Ser Leu Ala Tyr Val Ser Phe Asp Asn Met Gln Cys 
        35                  40                  45              


Thr Gly Thr Leu Val Ser Pro Thr Ala Val Leu Thr Ala Arg His Cys 
    50                  55                  60                  


Leu Asn Gly Gly Leu Gly His Val Arg Leu Gly Ala Asp His Phe Thr 
65                  70                  75                  80  


Ala Val Arg Ala Val Ala His Pro Gln Ala Asp Leu Ala Val Leu His 
                85                  90                  95      


Leu Asp Arg Pro Ala Pro Ile Ala Pro Ser Ala Ile Ser Gly Arg His 
            100                 105                 110         


Thr Gln Pro Gly Asn Arg Phe Gly Val Ala Gly Tyr Gly Ser Thr Phe 
        115                 120                 125             


Thr Gly Ile Pro Met Ala Ala Ala Ala Thr Met Gln Arg Arg Val Thr 
    130                 135                 140                 


Asp Val Pro Ser Pro Asp Arg Gln Ala Val Met Ile Glu Asn His Ile 
145                 150                 155                 160 


Ser Gln Gly Val Leu Arg Pro Gly Asp Ser Gly Gly Pro Leu Leu Glu 
                165                 170                 175     


Gly Asn His Val Ile Gly Val Leu Ser Met Ser Ser Ala Ser Gly Arg 
            180                 185                 190         


Val Gly Trp Tyr Ile Pro Thr Ala Glu His Ala Asp Trp Ile Ala Ala 
        195                 200                 205             


Ala Ala Gly Ile Pro Ala Pro Gly Ser Val Asp Lys Pro Ala Pro Leu 
    210                 215                 220                 


Val Asp Ala Thr Ala Phe Pro Thr Gln Glu Pro Ser Leu Ala Ser Leu 
225                 230                 235                 240 


Ser Ser 
        


<210> 36
<211> 729
<212> DNA
<213> Corynebacterium diphtheriae

<400> 36
atgaagaaac ttcgtaccct agccgtaacc ctgaccgcaa tcgcagcatc aaccatggcg       60

accatgccag cacaagcagt gattagtccg acaccgtcac atcaagtttc gctagcgtac      120

gtcagttttg acaacatgca gtgcaccggc acactcgtca gccccaccgc cgtgctcaca      180

gcacgacact gcctcaacgg cggcctcggc cacgtccgac tcggcgccga tcacttcacc      240

gccgtacgtg ccgtggcaca cccccaagca gaccttgccg tcctccacct cgatcgccca      300

gcgccaatag cgccatccgc aatctctgga cgtcacaccc aaccaggtaa ccgcttcgga      360

gttgccggct acggaagcac cttcaccggc atccccatgg cagcagctgc aaccatgcaa      420

cgccgcgtca ccgacgtccc cagccccgac cgccaagcag tcatgatcga aaaccacatc      480

agccaaggtg tactacgccc aggcgactct ggcggccccc tcctagaggg caatcacgtc      540

ataggagtac tcagcatgag cagtgcatcc ggccgcgtcg gctggtacat ccccaccgca      600

gaacacgccg actggatcgc ggcggcagcc ggaatccccg caccgggaag cgtcgacaag      660

cccgctccgc tcgtcgacgc cacagccttc ccgacgcaag agccaagcct cgctagccta      720

tcctcctag                                                              729


<210> 37
<211> 1012
<212> DNA
<213> Corynebacterium diphtheriae

<400> 37
ggatccgggc ttatcaccgc agaagacgcc gaaaaagcca tcgatgccac cctcctagcc       60

gtcgacggca tcacacgcca taacgacgac cccatggcat ggctcgccgc tatgggatac      120

ccactaacat gggcaaaaaa catcacgctt aaggaggccg aatgattacc gtctatcaca      180

acccccgctg ctccacctcg cgcaaagcct tggagtacat agaacaacac agcgacgacg      240

aggtgaccat catccgctac ctcgacgccc ctcctagtga acaagagctg cgcactttgc      300

ttgccgacgc ccacctcagc ccgcacgacg caatccgcac caaagaagcc gaatacaaag      360

aactcggact cagctccacc acccccgaat cagagctaat caaggccatg gtcacccacc      420

cacgcctcat tcagcgccca attgtggcaa catgcaaggg aacgcggatc gcccgaccaa      480

ccgaaattct gaaagaaatt ctctagccga atcgccagcg atctcggaag ccaaggaatc      540

cttcggcatg ttaaaaaatg taaaagttta atgcgggcac aaacgcgttg aaagagcaac      600

acaccaccat cgttgaacat acttgattat ttcccacttt ccagaatttt aatgagcatg      660

cccagctcga catcaagaac gcagggaaga tctcactagc aatcgacgat aggcccttct      720

tcgacaaccc ggaacatctt gccacgtacg acggaactac actggcagga tcgtcaatat      780

gtggtgaatt ccctgttaaa gtaggaagaa cagagggtgt cagtccgttt gtgtacgggg      840

actgacaccc tctgttcaaa tgattcatcg aagacggttt cacttttcta gcaaaacagc      900

aagacccgca agatttcata tattggtcaa gcgcagccac aaactatcac tcatagctat      960

gtagccccct attaattcat atctcaaaga gtatccaagc actttgggat cc             1012


<210> 38
<211> 558
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 38
Met Ser Arg Lys Leu Phe Ala Ser Ile Leu Ile Gly Ala Leu Leu Gly 
1               5                   10                  15      


Ile Gly Ala Pro Pro Ser Ala His Ala Met His His His His His His 
            20                  25                  30          


Glu Asn Leu Tyr Phe Gln Gly Ala Asp Asp Val Ala Asp Ser Ser Lys 
        35                  40                  45              


Ser Phe Val Met Glu Asn Phe Ser Ser Tyr His Gly Thr Lys Pro Gly 
    50                  55                  60                  


Tyr Val Asp Ser Ile Gln Lys Gly Ile Gln Lys Pro Lys Ser Gly Thr 
65                  70                  75                  80  


Gln Gly Asn Tyr Asp Asp Asp Trp Lys Gly Phe Tyr Ser Thr Asp Asn 
                85                  90                  95      


Lys Tyr Asp Ala Ala Gly Tyr Ser Val Asp Asn Glu Asn Pro Leu Ser 
            100                 105                 110         


Gly Lys Ala Gly Gly Val Val Lys Val Thr Tyr Pro Gly Leu Thr Lys 
        115                 120                 125             


Val Leu Ala Leu Lys Val Asp Asn Ala Glu Thr Ile Lys Lys Glu Leu 
    130                 135                 140                 


Gly Leu Ser Leu Thr Glu Pro Leu Met Glu Gln Val Gly Thr Glu Glu 
145                 150                 155                 160 


Phe Ile Lys Arg Phe Gly Asp Gly Ala Ser Arg Val Val Leu Ser Leu 
                165                 170                 175     


Pro Phe Ala Glu Gly Ser Ser Ser Val Glu Tyr Ile Asn Asn Trp Glu 
            180                 185                 190         


Gln Ala Lys Ala Leu Ser Val Glu Leu Glu Ile Asn Phe Glu Thr Arg 
        195                 200                 205             


Gly Lys Arg Gly Gln Asp Ala Met Tyr Glu Tyr Met Ala Gln Ala Cys 
    210                 215                 220                 


Ala Gly Asn Arg Val Arg Arg Ser Val Gly Ser Ser Leu Ser Cys Ile 
225                 230                 235                 240 


Asn Leu Asp Trp Asp Val Ile Arg Asp Lys Thr Lys Thr Lys Ile Glu 
                245                 250                 255     


Ser Leu Lys Glu His Gly Pro Ile Lys Asn Lys Met Ser Glu Ser Pro 
            260                 265                 270         


Asn Lys Thr Val Ser Glu Glu Lys Ala Lys Gln Tyr Leu Glu Glu Phe 
        275                 280                 285             


His Gln Thr Ala Leu Glu His Pro Glu Leu Ser Glu Leu Lys Thr Val 
    290                 295                 300                 


Thr Gly Thr Asn Pro Val Phe Ala Gly Ala Asn Tyr Ala Ala Trp Ala 
305                 310                 315                 320 


Val Asn Val Ala Gln Val Ile Asp Ser Glu Thr Ala Asp Asn Leu Glu 
                325                 330                 335     


Lys Thr Thr Ala Ala Leu Ser Ile Leu Pro Gly Ile Gly Ser Val Met 
            340                 345                 350         


Gly Ile Ala Asp Gly Ala Val His His Asn Thr Glu Glu Ile Val Ala 
        355                 360                 365             


Gln Ser Ile Ala Leu Ser Ser Leu Met Val Ala Gln Ala Ile Pro Leu 
    370                 375                 380                 


Val Gly Glu Leu Val Asp Ile Gly Phe Ala Ala Tyr Asn Phe Val Glu 
385                 390                 395                 400 


Ser Ile Ile Asn Leu Phe Gln Val Val His Asn Ser Tyr Asn Arg Pro 
                405                 410                 415     


Ala Tyr Ser Pro Gly His Lys Thr His Ala Pro Thr Ser Ser Ser Thr 
            420                 425                 430         


Lys Lys Thr Gln Leu Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met 
        435                 440                 445             


Ile Leu Asn Gly Ile Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met 
    450                 455                 460                 


Leu Thr Phe Lys Phe Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His 
465                 470                 475                 480 


Leu Gln Cys Leu Glu Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn 
                485                 490                 495     


Leu Ala Gln Ser Lys Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser 
            500                 505                 510         


Asn Ile Asn Val Ile Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe 
        515                 520                 525             


Met Cys Glu Tyr Ala Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn 
    530                 535                 540                 


Arg Trp Ile Thr Phe Cys Gln Ser Ile Ile Ser Thr Leu Thr 
545                 550                 555             


<210> 39
<211> 533
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 39
Met His His His His His His Glu Asn Leu Tyr Phe Gln Gly Ala Asp 
1               5                   10                  15      


Asp Val Ala Asp Ser Ser Lys Ser Phe Val Met Glu Asn Phe Ser Ser 
            20                  25                  30          


Tyr His Gly Thr Lys Pro Gly Tyr Val Asp Ser Ile Gln Lys Gly Ile 
        35                  40                  45              


Gln Lys Pro Lys Ser Gly Thr Gln Gly Asn Tyr Asp Asp Asp Trp Lys 
    50                  55                  60                  


Gly Phe Tyr Ser Thr Asp Asn Lys Tyr Asp Ala Ala Gly Tyr Ser Val 
65                  70                  75                  80  


Asp Asn Glu Asn Pro Leu Ser Gly Lys Ala Gly Gly Val Val Lys Val 
                85                  90                  95      


Thr Tyr Pro Gly Leu Thr Lys Val Leu Ala Leu Lys Val Asp Asn Ala 
            100                 105                 110         


Glu Thr Ile Lys Lys Glu Leu Gly Leu Ser Leu Thr Glu Pro Leu Met 
        115                 120                 125             


Glu Gln Val Gly Thr Glu Glu Phe Ile Lys Arg Phe Gly Asp Gly Ala 
    130                 135                 140                 


Ser Arg Val Val Leu Ser Leu Pro Phe Ala Glu Gly Ser Ser Ser Val 
145                 150                 155                 160 


Glu Tyr Ile Asn Asn Trp Glu Gln Ala Lys Ala Leu Ser Val Glu Leu 
                165                 170                 175     


Glu Ile Asn Phe Glu Thr Arg Gly Lys Arg Gly Gln Asp Ala Met Tyr 
            180                 185                 190         


Glu Tyr Met Ala Gln Ala Cys Ala Gly Asn Arg Val Arg Arg Ser Val 
        195                 200                 205             


Gly Ser Ser Leu Ser Cys Ile Asn Leu Asp Trp Asp Val Ile Arg Asp 
    210                 215                 220                 


Lys Thr Lys Thr Lys Ile Glu Ser Leu Lys Glu His Gly Pro Ile Lys 
225                 230                 235                 240 


Asn Lys Met Ser Glu Ser Pro Asn Lys Thr Val Ser Glu Glu Lys Ala 
                245                 250                 255     


Lys Gln Tyr Leu Glu Glu Phe His Gln Thr Ala Leu Glu His Pro Glu 
            260                 265                 270         


Leu Ser Glu Leu Lys Thr Val Thr Gly Thr Asn Pro Val Phe Ala Gly 
        275                 280                 285             


Ala Asn Tyr Ala Ala Trp Ala Val Asn Val Ala Gln Val Ile Asp Ser 
    290                 295                 300                 


Glu Thr Ala Asp Asn Leu Glu Lys Thr Thr Ala Ala Leu Ser Ile Leu 
305                 310                 315                 320 


Pro Gly Ile Gly Ser Val Met Gly Ile Ala Asp Gly Ala Val His His 
                325                 330                 335     


Asn Thr Glu Glu Ile Val Ala Gln Ser Ile Ala Leu Ser Ser Leu Met 
            340                 345                 350         


Val Ala Gln Ala Ile Pro Leu Val Gly Glu Leu Val Asp Ile Gly Phe 
        355                 360                 365             


Ala Ala Tyr Asn Phe Val Glu Ser Ile Ile Asn Leu Phe Gln Val Val 
    370                 375                 380                 


His Asn Ser Tyr Asn Arg Pro Ala Tyr Ser Pro Gly His Lys Thr His 
385                 390                 395                 400 


Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
                405                 410                 415     


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            420                 425                 430         


Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys 
        435                 440                 445             


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    450                 455                 460                 


Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu 
465                 470                 475                 480 


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                485                 490                 495     


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            500                 505                 510         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile 
        515                 520                 525             


Ile Ser Thr Leu Thr 
    530             


<210> 40
<211> 520
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 40
Gly Ala Asp Asp Val Ala Asp Ser Ser Lys Ser Phe Val Met Glu Asn 
1               5                   10                  15      


Phe Ser Ser Tyr His Gly Thr Lys Pro Gly Tyr Val Asp Ser Ile Gln 
            20                  25                  30          


Lys Gly Ile Gln Lys Pro Lys Ser Gly Thr Gln Gly Asn Tyr Asp Asp 
        35                  40                  45              


Asp Trp Lys Gly Phe Tyr Ser Thr Asp Asn Lys Tyr Asp Ala Ala Gly 
    50                  55                  60                  


Tyr Ser Val Asp Asn Glu Asn Pro Leu Ser Gly Lys Ala Gly Gly Val 
65                  70                  75                  80  


Val Lys Val Thr Tyr Pro Gly Leu Thr Lys Val Leu Ala Leu Lys Val 
                85                  90                  95      


Asp Asn Ala Glu Thr Ile Lys Lys Glu Leu Gly Leu Ser Leu Thr Glu 
            100                 105                 110         


Pro Leu Met Glu Gln Val Gly Thr Glu Glu Phe Ile Lys Arg Phe Gly 
        115                 120                 125             


Asp Gly Ala Ser Arg Val Val Leu Ser Leu Pro Phe Ala Glu Gly Ser 
    130                 135                 140                 


Ser Ser Val Glu Tyr Ile Asn Asn Trp Glu Gln Ala Lys Ala Leu Ser 
145                 150                 155                 160 


Val Glu Leu Glu Ile Asn Phe Glu Thr Arg Gly Lys Arg Gly Gln Asp 
                165                 170                 175     


Ala Met Tyr Glu Tyr Met Ala Gln Ala Cys Ala Gly Asn Arg Val Arg 
            180                 185                 190         


Arg Ser Val Gly Ser Ser Leu Ser Cys Ile Asn Leu Asp Trp Asp Val 
        195                 200                 205             


Ile Arg Asp Lys Thr Lys Thr Lys Ile Glu Ser Leu Lys Glu His Gly 
    210                 215                 220                 


Pro Ile Lys Asn Lys Met Ser Glu Ser Pro Asn Lys Thr Val Ser Glu 
225                 230                 235                 240 


Glu Lys Ala Lys Gln Tyr Leu Glu Glu Phe His Gln Thr Ala Leu Glu 
                245                 250                 255     


His Pro Glu Leu Ser Glu Leu Lys Thr Val Thr Gly Thr Asn Pro Val 
            260                 265                 270         


Phe Ala Gly Ala Asn Tyr Ala Ala Trp Ala Val Asn Val Ala Gln Val 
        275                 280                 285             


Ile Asp Ser Glu Thr Ala Asp Asn Leu Glu Lys Thr Thr Ala Ala Leu 
    290                 295                 300                 


Ser Ile Leu Pro Gly Ile Gly Ser Val Met Gly Ile Ala Asp Gly Ala 
305                 310                 315                 320 


Val His His Asn Thr Glu Glu Ile Val Ala Gln Ser Ile Ala Leu Ser 
                325                 330                 335     


Ser Leu Met Val Ala Gln Ala Ile Pro Leu Val Gly Glu Leu Val Asp 
            340                 345                 350         


Ile Gly Phe Ala Ala Tyr Asn Phe Val Glu Ser Ile Ile Asn Leu Phe 
        355                 360                 365             


Gln Val Val His Asn Ser Tyr Asn Arg Pro Ala Tyr Ser Pro Gly His 
    370                 375                 380                 


Lys Thr His Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln 
385                 390                 395                 400 


Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn 
                405                 410                 415     


Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr 
            420                 425                 430         


Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu 
        435                 440                 445             


Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn 
    450                 455                 460                 


Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val 
465                 470                 475                 480 


Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp 
                485                 490                 495     


Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys 
            500                 505                 510         


Gln Ser Ile Ile Ser Thr Leu Thr 
        515                 520 


<210> 41
<211> 1677
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 41
gtgagcagaa aactgtttgc gtcaatctta ataggggcgc tactggggat aggggcccca       60

ccttcagccc atgcaatgca tcaccaccac caccacgaga acctgtactt ccagggcgct      120

gatgatgttg ctgattcttc taaatctttt gtgatggaaa acttttcttc gtaccacggg      180

actaaacctg gttatgtaga ttccattcaa aaaggtatac aaaagccaaa atctggtaca      240

caaggaaatt atgacgatga ttggaaaggg ttttatagta ccgacaataa atacgacgct      300

gcgggatact ctgtagataa tgaaaacccg ctctctggaa aagctggagg cgtggtcaaa      360

gtgacgtatc caggactgac gaaggttctc gcactaaaag tggataatgc cgaaactatt      420

aagaaagagt taggtttaag tctcactgaa ccgttgatgg agcaagtcgg aacggaagag      480

tttatcaaaa ggttcggtga tggtgcttcg cgtgtagtgc tcagccttcc cttcgctgag      540

gggagttcta gcgttgaata tattaataac tgggaacagg cgaaagcgtt aagcgtagaa      600

cttgagatta attttgaaac ccgtggaaaa cgtggccaag atgcgatgta tgagtatatg      660

gctcaagcct gtgcaggaaa tcgtgtcagg cgatcagtag gtagctcatt gtcatgcatc      720

aacctggatt gggatgttat ccgtgataaa actaaaacta agatcgaatc tctgaaagaa      780

cacggtccga tcaaaaacaa aatgagcgaa agcccgaaca aaactgtatc tgaagaaaaa      840

gctaaacagt acctggaaga attccaccag actgcactgg aacacccgga actgtctgaa      900

cttaagaccg ttactggtac caacccggta ttcgctggtg ctaactacgc tgcttgggca      960

gtaaacgttg ctcaggttat cgatagcgaa actgctgata acctggaaaa aactaccgcg     1020

gctctgtcta tcctgccggg tatcggtagc gtaatgggca tcgcagacgg cgccgttcac     1080

cacaacactg aagaaatcgt tgcacagtct atcgctctga gctctctgat ggttgctcag     1140

gccatcccgc tggtaggtga actggttgat atcggtttcg ctgcatacaa cttcgttgaa     1200

agcatcatca acctgttcca ggttgttcac aactcttaca accgcccggc ttactctccg     1260

ggtcacaaga cgcatgcacc tacttctagc tctaccaaga aaacccagct gcagctcgag     1320

cacctgctgc tggatttgca gatgatcctg aacggtatca acaattacaa gaacccgaaa     1380

ctgacgcgta tgctgacctt caagttctac atgccgaaga aggccaccga actgaaacac     1440

ctgcagtgtc tagaagaaga actgaaaccg ctggaggaag ttctgaacct ggctcagtct     1500

aaaaacttcc acctgcggcc gcgtgacctg atctctaaca tcaacgtaat cgttctggaa     1560

ctgaagggct ctgaaaccac cttcatgtgt gaatacgctg atgagaccgc aaccatcgta     1620

gaattcctga accgttggat caccttctgt cagtctatca tctctaccct gacctga        1677


<210> 42
<211> 551
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 42
Met Ser Arg Lys Leu Phe Ala Ser Ile Leu Ile Gly Ala Leu Leu Gly 
1               5                   10                  15      


Ile Gly Ala Pro Pro Ser Ala His Ala Gly Ala Asp Asp Val Ala Asp 
            20                  25                  30          


Ser Ser Lys Ser Phe Val Met Glu Asn Phe Ser Ser Tyr His Gly Thr 
        35                  40                  45              


Lys Pro Gly Tyr Val Asp Ser Ile Gln Lys Gly Ile Gln Lys Pro Lys 
    50                  55                  60                  


Ser Gly Thr Gln Gly Asn Tyr Asp Asp Asp Trp Lys Gly Phe Tyr Ser 
65                  70                  75                  80  


Thr Asp Asn Lys Tyr Asp Ala Ala Gly Tyr Ser Val Asp Asn Glu Asn 
                85                  90                  95      


Pro Leu Ser Gly Lys Ala Gly Gly Val Val Lys Val Thr Tyr Pro Gly 
            100                 105                 110         


Leu Thr Lys Val Leu Ala Leu Lys Val Asp Asn Ala Glu Thr Ile Lys 
        115                 120                 125             


Lys Glu Leu Gly Leu Ser Leu Thr Glu Pro Leu Met Glu Gln Val Gly 
    130                 135                 140                 


Thr Glu Glu Phe Ile Lys Arg Phe Gly Asp Gly Ala Ser Arg Val Val 
145                 150                 155                 160 


Leu Ser Leu Pro Phe Ala Glu Gly Ser Ser Ser Val Glu Tyr Ile Asn 
                165                 170                 175     


Asn Trp Glu Gln Ala Lys Ala Leu Ser Val Glu Leu Glu Ile Asn Phe 
            180                 185                 190         


Glu Thr Arg Gly Lys Arg Gly Gln Asp Ala Met Tyr Glu Tyr Met Ala 
        195                 200                 205             


Gln Ala Cys Ala Gly Asn Arg Val Arg Arg Ser Val Gly Ser Ser Leu 
    210                 215                 220                 


Ser Cys Ile Asn Leu Asp Trp Asp Val Ile Arg Asp Lys Thr Lys Thr 
225                 230                 235                 240 


Lys Ile Glu Ser Leu Lys Glu His Gly Pro Ile Lys Asn Lys Met Ser 
                245                 250                 255     


Glu Ser Pro Asn Lys Thr Val Ser Glu Glu Lys Ala Lys Gln Tyr Leu 
            260                 265                 270         


Glu Glu Phe His Gln Thr Ala Leu Glu His Pro Glu Leu Ser Glu Leu 
        275                 280                 285             


Lys Thr Val Thr Gly Thr Asn Pro Val Phe Ala Gly Ala Asn Tyr Ala 
    290                 295                 300                 


Ala Trp Ala Val Asn Val Ala Gln Val Ile Asp Ser Glu Thr Ala Asp 
305                 310                 315                 320 


Asn Leu Glu Lys Thr Thr Ala Ala Leu Ser Ile Leu Pro Gly Ile Gly 
                325                 330                 335     


Ser Val Met Gly Ile Ala Asp Gly Ala Val His His Asn Thr Glu Glu 
            340                 345                 350         


Ile Val Ala Gln Ser Ile Ala Leu Ser Ser Leu Met Val Ala Gln Ala 
        355                 360                 365             


Ile Pro Leu Val Gly Glu Leu Val Asp Ile Gly Phe Ala Ala Tyr Asn 
    370                 375                 380                 


Phe Val Glu Ser Ile Ile Asn Leu Phe Gln Val Val His Asn Ser Tyr 
385                 390                 395                 400 


Asn Arg Pro Ala Tyr Ser Pro Gly His Lys Thr His Ala Pro Thr Ser 
                405                 410                 415     


Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His Leu Leu Leu Asp 
            420                 425                 430         


Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys Asn Pro Lys Leu 
        435                 440                 445             


Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys Lys Ala Thr Glu 
    450                 455                 460                 


Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys Pro Leu Glu Glu 
465                 470                 475                 480 


Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu Arg Pro Arg Asp 
                485                 490                 495     


Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu Lys Gly Ser Glu 
            500                 505                 510         


Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala Thr Ile Val Glu 
        515                 520                 525             


Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile Ile Ser Thr Leu 
    530                 535                 540                 


Thr His His His His His His 
545                 550     


<210> 43
<211> 526
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 43
Gly Ala Asp Asp Val Ala Asp Ser Ser Lys Ser Phe Val Met Glu Asn 
1               5                   10                  15      


Phe Ser Ser Tyr His Gly Thr Lys Pro Gly Tyr Val Asp Ser Ile Gln 
            20                  25                  30          


Lys Gly Ile Gln Lys Pro Lys Ser Gly Thr Gln Gly Asn Tyr Asp Asp 
        35                  40                  45              


Asp Trp Lys Gly Phe Tyr Ser Thr Asp Asn Lys Tyr Asp Ala Ala Gly 
    50                  55                  60                  


Tyr Ser Val Asp Asn Glu Asn Pro Leu Ser Gly Lys Ala Gly Gly Val 
65                  70                  75                  80  


Val Lys Val Thr Tyr Pro Gly Leu Thr Lys Val Leu Ala Leu Lys Val 
                85                  90                  95      


Asp Asn Ala Glu Thr Ile Lys Lys Glu Leu Gly Leu Ser Leu Thr Glu 
            100                 105                 110         


Pro Leu Met Glu Gln Val Gly Thr Glu Glu Phe Ile Lys Arg Phe Gly 
        115                 120                 125             


Asp Gly Ala Ser Arg Val Val Leu Ser Leu Pro Phe Ala Glu Gly Ser 
    130                 135                 140                 


Ser Ser Val Glu Tyr Ile Asn Asn Trp Glu Gln Ala Lys Ala Leu Ser 
145                 150                 155                 160 


Val Glu Leu Glu Ile Asn Phe Glu Thr Arg Gly Lys Arg Gly Gln Asp 
                165                 170                 175     


Ala Met Tyr Glu Tyr Met Ala Gln Ala Cys Ala Gly Asn Arg Val Arg 
            180                 185                 190         


Arg Ser Val Gly Ser Ser Leu Ser Cys Ile Asn Leu Asp Trp Asp Val 
        195                 200                 205             


Ile Arg Asp Lys Thr Lys Thr Lys Ile Glu Ser Leu Lys Glu His Gly 
    210                 215                 220                 


Pro Ile Lys Asn Lys Met Ser Glu Ser Pro Asn Lys Thr Val Ser Glu 
225                 230                 235                 240 


Glu Lys Ala Lys Gln Tyr Leu Glu Glu Phe His Gln Thr Ala Leu Glu 
                245                 250                 255     


His Pro Glu Leu Ser Glu Leu Lys Thr Val Thr Gly Thr Asn Pro Val 
            260                 265                 270         


Phe Ala Gly Ala Asn Tyr Ala Ala Trp Ala Val Asn Val Ala Gln Val 
        275                 280                 285             


Ile Asp Ser Glu Thr Ala Asp Asn Leu Glu Lys Thr Thr Ala Ala Leu 
    290                 295                 300                 


Ser Ile Leu Pro Gly Ile Gly Ser Val Met Gly Ile Ala Asp Gly Ala 
305                 310                 315                 320 


Val His His Asn Thr Glu Glu Ile Val Ala Gln Ser Ile Ala Leu Ser 
                325                 330                 335     


Ser Leu Met Val Ala Gln Ala Ile Pro Leu Val Gly Glu Leu Val Asp 
            340                 345                 350         


Ile Gly Phe Ala Ala Tyr Asn Phe Val Glu Ser Ile Ile Asn Leu Phe 
        355                 360                 365             


Gln Val Val His Asn Ser Tyr Asn Arg Pro Ala Tyr Ser Pro Gly His 
    370                 375                 380                 


Lys Thr His Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln 
385                 390                 395                 400 


Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn 
                405                 410                 415     


Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr 
            420                 425                 430         


Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu 
        435                 440                 445             


Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn 
    450                 455                 460                 


Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val 
465                 470                 475                 480 


Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp 
                485                 490                 495     


Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys 
            500                 505                 510         


Gln Ser Ile Ile Ser Thr Leu Thr His His His His His His 
        515                 520                 525     


<210> 44
<211> 1656
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 44
gtgagcagaa aactgtttgc gtcaatctta ataggggcgc tactggggat aggggcccca       60

ccttcagccc atgcaggcgc tgatgatgtt gctgattctt ctaaatcttt tgtgatggaa      120

aacttttctt cgtaccacgg gactaaacct ggttatgtag attccattca aaaaggtata      180

caaaagccaa aatctggtac acaaggaaat tatgacgatg attggaaagg gttttatagt      240

accgacaata aatacgacgc tgcgggatac tctgtagata atgaaaaccc gctctctgga      300

aaagctggag gcgtggtcaa agtgacgtat ccaggactga cgaaggttct cgcactaaaa      360

gtggataatg ccgaaactat taagaaagag ttaggtttaa gtctcactga accgttgatg      420

gagcaagtcg gaacggaaga gtttatcaaa aggttcggtg atggtgcttc gcgtgtagtg      480

ctcagccttc ccttcgctga ggggagttct agcgttgaat atattaataa ctgggaacag      540

gcgaaagcgt taagcgtaga acttgagatt aattttgaaa cccgtggaaa acgtggccaa      600

gatgcgatgt atgagtatat ggctcaagcc tgtgcaggaa atcgtgtcag gcgatcagta      660

ggtagctcat tgtcatgcat caacctggat tgggatgtta tccgtgataa aactaaaact      720

aagatcgaat ctctgaaaga acacggtccg atcaaaaaca aaatgagcga aagcccgaac      780

aaaactgtat ctgaagaaaa agctaaacag tacctggaag aattccacca gactgcactg      840

gaacacccgg aactgtctga acttaagacc gttactggta ccaacccggt attcgctggt      900

gctaactacg ctgcttgggc agtaaacgtt gctcaggtta tcgatagcga aactgctgat      960

aacctggaaa aaactaccgc ggctctgtct atcctgccgg gtatcggtag cgtaatgggc     1020

atcgcagacg gcgccgttca ccacaacact gaagaaatcg ttgcacagtc tatcgctctg     1080

agctctctga tggttgctca ggccatcccg ctggtaggtg aactggttga tatcggtttc     1140

gctgcataca acttcgttga aagcatcatc aacctgttcc aggttgttca caactcttac     1200

aaccgcccgg cttactctcc gggtcacaag acgcatgcac ctacttctag ctctaccaag     1260

aaaacccagc tgcagctcga gcacctgctg ctggatttgc agatgatcct gaacggtatc     1320

aacaattaca agaacccgaa actgacgcgt atgctgacct tcaagttcta catgccgaag     1380

aaggccaccg aactgaaaca cctgcagtgt ctagaagaag aactgaaacc gctggaggaa     1440

gttctgaacc tggctcagtc taaaaacttc cacctgcggc cgcgtgacct gatctctaac     1500

atcaacgtaa tcgttctgga actgaagggc tctgaaacca ccttcatgtg tgaatacgct     1560

gatgagaccg caaccatcgt agaattcctg aaccgttgga tcaccttctg tcagtctatc     1620

atctctaccc tgacccacca tcaccatcat cactga                               1656


<210> 45
<211> 561
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 45
Met Ser Arg Lys Leu Phe Ala Ser Ile Leu Ile Gly Ala Leu Leu Gly 
1               5                   10                  15      


Ile Gly Ala Pro Pro Ser Ala His Ala Gly Ala Asp Asp Val Ala Asp 
            20                  25                  30          


Ser Ser Lys Ser Phe Val Met Glu Asn Phe Ser Ser Tyr His Gly Thr 
        35                  40                  45              


Lys Pro Gly Tyr Val Asp Ser Ile Gln Lys Gly Ile Gln Lys Pro Lys 
    50                  55                  60                  


Ser Gly Thr Gln Gly Asn Tyr Asp Asp Asp Trp Lys Gly Phe Tyr Ser 
65                  70                  75                  80  


Thr Asp Asn Lys Tyr Asp Ala Ala Gly Tyr Ser Val Asp Asn Glu Asn 
                85                  90                  95      


Pro Leu Ser Gly Lys Ala Gly Gly Val Val Lys Val Thr Tyr Pro Gly 
            100                 105                 110         


Leu Thr Lys Val Leu Ala Leu Lys Val Asp Asn Ala Glu Thr Ile Lys 
        115                 120                 125             


Lys Glu Leu Gly Leu Ser Leu Thr Glu Pro Leu Met Glu Gln Val Gly 
    130                 135                 140                 


Thr Glu Glu Phe Ile Lys Arg Phe Gly Asp Gly Ala Ser Arg Val Val 
145                 150                 155                 160 


Leu Ser Leu Pro Phe Ala Glu Gly Ser Ser Ser Val Glu Tyr Ile Asn 
                165                 170                 175     


Asn Trp Glu Gln Ala Lys Ala Leu Ser Val Glu Leu Glu Ile Asn Phe 
            180                 185                 190         


Glu Thr Arg Gly Lys Arg Gly Gln Asp Ala Met Tyr Glu Tyr Met Ala 
        195                 200                 205             


Gln Ala Cys Ala Gly Asn Arg Val Arg Arg Ser Val Gly Ser Ser Leu 
    210                 215                 220                 


Ser Cys Ile Asn Leu Asp Trp Asp Val Ile Arg Asp Lys Thr Lys Thr 
225                 230                 235                 240 


Lys Ile Glu Ser Leu Lys Glu His Gly Pro Ile Lys Asn Lys Met Ser 
                245                 250                 255     


Glu Ser Pro Asn Lys Thr Val Ser Glu Glu Lys Ala Lys Gln Tyr Leu 
            260                 265                 270         


Glu Glu Phe His Gln Thr Ala Leu Glu His Pro Glu Leu Ser Glu Leu 
        275                 280                 285             


Lys Thr Val Thr Gly Thr Asn Pro Val Phe Ala Gly Ala Asn Tyr Ala 
    290                 295                 300                 


Ala Trp Ala Val Asn Val Ala Gln Val Ile Asp Ser Glu Thr Ala Asp 
305                 310                 315                 320 


Asn Leu Glu Lys Thr Thr Ala Ala Leu Ser Ile Leu Pro Gly Ile Gly 
                325                 330                 335     


Ser Val Met Gly Ile Ala Asp Gly Ala Val His His Asn Thr Glu Glu 
            340                 345                 350         


Ile Val Ala Gln Ser Ile Ala Leu Ser Ser Leu Met Val Ala Gln Ala 
        355                 360                 365             


Ile Pro Leu Val Gly Glu Leu Val Asp Ile Gly Phe Ala Ala Tyr Asn 
    370                 375                 380                 


Phe Val Glu Ser Ile Ile Asn Leu Phe Gln Val Val His Asn Ser Tyr 
385                 390                 395                 400 


Asn Arg Pro Ala Tyr Ser Pro Gly His Lys Thr His Ala Pro Thr Ser 
                405                 410                 415     


Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His Leu Leu Leu Asp 
            420                 425                 430         


Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys Asn Pro Lys Leu 
        435                 440                 445             


Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys Lys Ala Thr Glu 
    450                 455                 460                 


Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys Pro Leu Glu Glu 
465                 470                 475                 480 


Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu Arg Pro Arg Asp 
                485                 490                 495     


Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu Lys Gly Ser Glu 
            500                 505                 510         


Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala Thr Ile Val Glu 
        515                 520                 525             


Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile Ile Ser Thr Leu 
    530                 535                 540                 


Thr Glu Asn Leu Tyr Phe Gln Gly His His His His His His His His 
545                 550                 555                 560 


His 
    


<210> 46
<211> 536
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 46
Gly Ala Asp Asp Val Ala Asp Ser Ser Lys Ser Phe Val Met Glu Asn 
1               5                   10                  15      


Phe Ser Ser Tyr His Gly Thr Lys Pro Gly Tyr Val Asp Ser Ile Gln 
            20                  25                  30          


Lys Gly Ile Gln Lys Pro Lys Ser Gly Thr Gln Gly Asn Tyr Asp Asp 
        35                  40                  45              


Asp Trp Lys Gly Phe Tyr Ser Thr Asp Asn Lys Tyr Asp Ala Ala Gly 
    50                  55                  60                  


Tyr Ser Val Asp Asn Glu Asn Pro Leu Ser Gly Lys Ala Gly Gly Val 
65                  70                  75                  80  


Val Lys Val Thr Tyr Pro Gly Leu Thr Lys Val Leu Ala Leu Lys Val 
                85                  90                  95      


Asp Asn Ala Glu Thr Ile Lys Lys Glu Leu Gly Leu Ser Leu Thr Glu 
            100                 105                 110         


Pro Leu Met Glu Gln Val Gly Thr Glu Glu Phe Ile Lys Arg Phe Gly 
        115                 120                 125             


Asp Gly Ala Ser Arg Val Val Leu Ser Leu Pro Phe Ala Glu Gly Ser 
    130                 135                 140                 


Ser Ser Val Glu Tyr Ile Asn Asn Trp Glu Gln Ala Lys Ala Leu Ser 
145                 150                 155                 160 


Val Glu Leu Glu Ile Asn Phe Glu Thr Arg Gly Lys Arg Gly Gln Asp 
                165                 170                 175     


Ala Met Tyr Glu Tyr Met Ala Gln Ala Cys Ala Gly Asn Arg Val Arg 
            180                 185                 190         


Arg Ser Val Gly Ser Ser Leu Ser Cys Ile Asn Leu Asp Trp Asp Val 
        195                 200                 205             


Ile Arg Asp Lys Thr Lys Thr Lys Ile Glu Ser Leu Lys Glu His Gly 
    210                 215                 220                 


Pro Ile Lys Asn Lys Met Ser Glu Ser Pro Asn Lys Thr Val Ser Glu 
225                 230                 235                 240 


Glu Lys Ala Lys Gln Tyr Leu Glu Glu Phe His Gln Thr Ala Leu Glu 
                245                 250                 255     


His Pro Glu Leu Ser Glu Leu Lys Thr Val Thr Gly Thr Asn Pro Val 
            260                 265                 270         


Phe Ala Gly Ala Asn Tyr Ala Ala Trp Ala Val Asn Val Ala Gln Val 
        275                 280                 285             


Ile Asp Ser Glu Thr Ala Asp Asn Leu Glu Lys Thr Thr Ala Ala Leu 
    290                 295                 300                 


Ser Ile Leu Pro Gly Ile Gly Ser Val Met Gly Ile Ala Asp Gly Ala 
305                 310                 315                 320 


Val His His Asn Thr Glu Glu Ile Val Ala Gln Ser Ile Ala Leu Ser 
                325                 330                 335     


Ser Leu Met Val Ala Gln Ala Ile Pro Leu Val Gly Glu Leu Val Asp 
            340                 345                 350         


Ile Gly Phe Ala Ala Tyr Asn Phe Val Glu Ser Ile Ile Asn Leu Phe 
        355                 360                 365             


Gln Val Val His Asn Ser Tyr Asn Arg Pro Ala Tyr Ser Pro Gly His 
    370                 375                 380                 


Lys Thr His Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln 
385                 390                 395                 400 


Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn 
                405                 410                 415     


Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr 
            420                 425                 430         


Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu 
        435                 440                 445             


Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn 
    450                 455                 460                 


Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val 
465                 470                 475                 480 


Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp 
                485                 490                 495     


Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys 
            500                 505                 510         


Gln Ser Ile Ile Ser Thr Leu Thr Glu Asn Leu Tyr Phe Gln Gly His 
        515                 520                 525             


His His His His His His His His 
    530                 535     


<210> 47
<211> 4679
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 47
ggatcccccg ggctgcagga attcgatatc aagcttatcg ataccgtcga cctcgagggg       60

gggcccggta ccagcttttg ttccctttag tgagggttaa tttcgagctt ggcgtaatca      120

tggtcatagc tgtttcctgt gtgaaattgt tatccgctca caattccaca caacatacga      180

gccggaagca taaagtgtaa agcctggggt gcctaatgag tgagtccccg atccgtcgag      240

ctcgacctgc aggggggggg gggcgctgag gtctgcctcg tgaagaaggt gttgctgact      300

cataccaggc ctgaatcgcc ccatcatcca gccagaaagt gagggagcca cggttgatga      360

gagctttgtt gtaggtggac cagttggtga ttttgaactt ttgctttgcc acggaacggt      420

ctgcgttgtc gggaagatgc gtgatctgat ccttcaactc agcaaaagtt cgatttattc      480

aacaaagccg ccgtcccgtc aagtcagcgt aatgctctgc cagtgttaca accaattaac      540

caattctgat tagaaaaact catcgagcat caaatgaaac tgcaatttat tcatatcagg      600

attatcaata ccatattttt gaaaaagccg tttctgtaat gaaggagaaa actcaccgag      660

gcagttccat aggatggcaa gatcctggta tcggtctgcg attccgactc gtccaacatc      720

aatacaacct attaatttcc cctcgtcaaa aataaggtta tcaagtgaga aatcaccatg      780

agtgacgact gaatccggtg agaatggcaa aagcttatgc atttctttcc agacttgttc      840

aacaggccag ccattacgct cgtcatcaaa atcactcgca tcaaccaaac cgttattcat      900

tcgtgattgc gcctgagcga gacgaaatac gcgatcgctg ttaaaaggac aattacaaac      960

aggaatcgaa tgcaaccggc gcaggaacac tgccagcgca tcaacaatat tttcacctga     1020

atcaggatat tcttctaata cctggaatgc tgttttcccg gggatcgcag tggtgagtaa     1080

ccatgcatca tcaggagtac ggataaaatg cttgatggtc ggaagaggca taaattccgt     1140

cagccagttt agtctgacca tctcatctgt aacatcattg gcaacgctac ctttgccatg     1200

tttcagaaac aactctggcg catcgggctt cccatacaat cgatagattg tcgcacctga     1260

ttgcccgaca ttatcgcgag cccatttata cccatataaa tcagcatcca tgttggaatt     1320

taatcgcggc ctcgagcaag acgtttcccg ttgaatatgg ctcataacac cccttgtatt     1380

actgtttatg taagcagaca gttttattgt tcatgatgat atatttttat cttgtgcaat     1440

gtaacatcag agattttgag acacaacgtg gctttccccc ccccccctgc aggtcgagct     1500

cgacggatcg ggctgcagga attcggtgag gttatggcgg agggttgcga ggtctaggag     1560

aacagaggaa gtcatgcttt gaagcatata agctgccctg cccctcaagg ttttcttcaa     1620

gtgaggtttt atctaactgc ctaacggcag gggaaccgta tattgcttac ggtatgagac     1680

cccttaaacg tccggatagt caccgctctt ctttagctcc gcgacatgcc tagcaaccgt     1740

ggcgcgagag actcctacct ctgcccctat ttcagcccac gtgggaactg tccctgtctg     1800

gaaatactga tcgttcacca tttggctaat acgggacttc gtagatcgtc cttgagcctt     1860

tttcttacgg tgcgtctttt caagcttcga cctttgtgct tgcgcatatt tgccctcggg     1920

gtctgttttc cagcgttgtg cggctttttg tccgcctctg cgtcccatcg tggccaaggc     1980

tttccgctcg ctgctggtgg ctttacctgg tgcgttagag ccgctgtagg tctcgctctt     2040

ggattgggcg acatacccgc gcacgcgcct tgccatggtt tggcggtcgc gcatgggtgg     2100

catctcgttg tcgcggcctg caccgccgtg ggtgtgtgcg acgttgtagg cgtgctcata     2160

ggcgtcgatg attgctgcgt ctgtcaggcg ttggccttgc tggcgcaagc ggtggccagt     2220

cttaagcgca tgtctaaagg ctgtttcgtc gcgtgctgcg gttccttgga caatccagag     2280

cacacgcaca ccgtcgataa gttccgggtc atactggtcg agaccaccgg cgatttccgc     2340

gtctacgtcc tgggcgagtg ctttgaatgc ttgggcttct tcacggcggg tcttgaccgc     2400

gttgataagt tcgcggccag agctgaattg ctggcgtggg gtggggttga actggtcgtg     2460

tcctgccata tcccttacct gctttatcaa gtctccaagg cgcatcaccc ggttgtgctg     2520

cctataccaa cgataagcgg taggggcttt gcctgtgtag aacgggttgc ggctaaagcg     2580

gtgggaaaag tgcgggtcat ggtctaaaag ctcacccagc acacgcgtgg ttgctgcaag     2640

aagcttcatc tgcgcagatt taccgttacg gtcagcgtag acagggtcaa taagccatat     2700

gaactgggct ttgccgttag ttgggttaat acccacccag gctggcccga cgctatgagt     2760

aatcagtgag cgcaccacgt cgcggacgta cgggtttaag tctgcggggt caccgcctgc     2820

ggtacctact tggtcaacgt ctacgaccag gacggcggcg tactgcttgg tggtgagcat     2880

ggcgtactcg caccgtccta aagcatcagt ctcgaagcga tacatacgcg gcgagttcgt     2940

gccgtcagcg ttgcgtcgat aggccttttt aaagtctcgt gtgactgaac cgtggagtac     3000

atcgcggcct agatgatcgc gtaaaaggtc gcggtcactg gcagatgctg gggtgttgtc     3060

cagtccacca cggtcgcgct cgacgcgggt aggtgtttta gtgtgcgcat tctgcgcatg     3120

agtctgtaaa ctcatgaccg tgctttctcc caggtgtgtg ctgggtgata agcgaaagtc     3180

atcgggttgc cgcccggtgg ctttcttcgt ttttcattgt ctttccctga ctctaaatga     3240

caccggtgtt atttactagc catgacacgc gaaaaatatg ccttttacct gcggttacgt     3300

atggctagac atatggcaag ctatacgtaa ccgcgtttca gctgcacagg gctgtctgcg     3360

cagatttacc atcacgggac ttttcccagt tcaggctgcg catatttacg catacaacga     3420

aagcggttgc gcagatttac cacacactct gcgctgattt accgatacgc agaaaaagcg     3480

tgcgcagatt tacccatacg gtggcgaatt atccagagca ataggtatac agcaatacag     3540

taatacaggt gccataaacc tgtattactg tattgctgta tgcctgtaaa cctttattta     3600

ttgttgtgga cgtattcttc gaggtaggtg ctaacaatct cgcggatggt cacgcctttt     3660

tgggcggcga tgactttaag ttctgcgtga aggtcgcggt cgatttcaat cgtcatcttc     3720

ttgacgtagt cgcggcctgt gggttggtgg aatgcgcttc gcactgtttt cttctcggct     3780

gctggagtta gcttcgtggc ttttttcatt gaggttcgcg ggccttgctg cgccctggcg     3840

cgttctttac tggtgctcat ttcatcatct ccatgagttc gtcggcgacg tggtcgtagc     3900

cgtgcatgtc ggggcctggg cagtatccaa acgctaggtg catatcttcg cgtagcggga     3960

tttcggtttt aaagtgcggc atgtgttccg cgtcgagcgc ttctcgtgcc gcgtcaaggg     4020

cgctggtgcc tttcctggcg aacgtcagta agactgcatg aggtgttccg ttgactgcgt     4080

cgcgcagctc ccatactcgg gagaggtcgg cagcagcaga acgggtcgga agaatgatga     4140

agtcgctgac tgcgattgct gcttcgatag cgttctcgtc tcctggcggc acatcgatac     4200

cgactgggcg atggcccact acgtgaacca tcaccctaat caagtttttt ggggtcgagg     4260

tgccgtaaag cactaaatcg gaaccctaaa gggagccccc gatttagagc ttgacgggga     4320

aagccggcga acgtggcgag aaaggaaggg aagaaagcga aaggagcggg cgctagggcg     4380

ctggcaagtg tagcggtcac gctgcgcgta accaccacac ccgccgcgct taatgcgccg     4440

ctacagggcg ctcccattcg ccattcaggc tgcgcaactg ttgggaaggg cgatcggtgc     4500

gggcctcttc gctattacgc cagctggcga aagggggatg tgctgcaagg cgattaagtt     4560

gggtaacgcc agggttttcc cagtcacgac gttgtaaaac gacggccagt gaattgtaat     4620

acgactcact atagggcgaa ttggagctcc accgcggtgg cggccgctct agaactagt      4679


<210> 48
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      9xHis tag

<400> 48
His His His His His His His His His 
1               5                   



