                         SEQUENCE LISTING

<110>  Board of Regents, The University of Texas System
       New York Medical College
 
<120>  20-HETE RECEPTOR (GPR75) ANTAGONISTS AND METHODS OF USE

<130>  UTSW:011WO

<150>  62/305,947
<151>  2016-03-09

<160>  2     

<170>  PatentIn version 3.5

<210>  1
<211>  7121
<212>  DNA
<213>  Homo sapiens

<400>  1
aggcccgggt gtccggcgga gggggcggtg ccctcggcgt ctccgtgact gcgcctctgc       60

gcccgcgtct tgccgcggct cccgggatgc gcggaggcgg tggcgatggc gatgatgcct      120

ctagtcctgc atcatccaga gcggcaggcg gagctggggt ccggactgcg agatggagga      180

ggggcggcgc tgcggccacc cggcaggtga gaggccgcgg gcccctggag gaggacaacc      240

ccacgatgcc ggagacggct cccggaggct ggcgggatag cgaggagcgc ggctgcgctg      300

ggccaggccc ggctccgcgt acctgtcttc ctggtgcggc ctgcagggta gccttctcgc      360

ccgtccctgc cggttcccag gctctgctcg gccgtggaac cccccccacc cacccaccca      420

ccgcccctac cctggctgag ccctcctaac ccaccacccc tctgcggcat tcttttgcaa      480

gcttacctgg cccggcctag gccctcctta ccgtcacctc acccttctcc gggaagcccc      540

tacccaccgc cagcccctca cgggggggtc gaccttccct gcccgcagtt tcccactctg      600

tcctcaggct gggggctccc tggcctcttc atccctccca tcaaatgact caggtcttcc      660

catcccatta gctgctccgg gttcaatgta gttctactgg atagaaagag caagggcttt      720

gaaatcagat aatgaccttg gggaagttat ctaacctccc tgaggttttc ctgatcgata      780

gaaatacaat gggaatcaca ataatacaga accttgctct ctgtgaggat taggctttga      840

aaatgctaac ctaagacatt ttggggcgcg cggggaatgg ggttggaaga attcaggtcg      900

tgagttgatt tatgaaagcc cctatagcat gttttaatgt tcactaaaaa tttaaaacag      960

cacactagat atatcagagg ctgttcacat atcttaatga aaaatcattg ccactcaaat     1020

tatacaataa attttcatcc atattctttg cttgctagtt acttcaggat gtctcatttg     1080

taagaatatg catgtgaatt cattcttact gcagctaata tgcatgctta agactggtgt     1140

tccagcttaa aatctttctg attttgtgac tttaatcaca tcttctataa cctattctcc     1200

gtcccagaga tgaagagtag cttgtatgtt tgcattgcaa ataacatggg taatctttat     1260

tgaatattta tgagtagcaa agcagtatta atttattccc cttccaaaac cacttttatt     1320

ttctgccgtc atcatgtcat tccaaattat ggtcacagcc tcctttttct taaagtctca     1380

ggagttacta ctaagacctg agtttacttt ccctccattt tcttgatttc tgttatacta     1440

aagtttttct gcaaaccttt tcgtcttttc tgtcctctgc tttttctccc ttttctcttc     1500

ccagcccatg attccttttt ttctaattat ctcaatagga gtgatttatg attactttat     1560

atgtgaacta cagttagata catagaagaa tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg     1620

tgtgtgtgtg tctatctgta tctacataga tgtagatata gctatatagg tgtatcagaa     1680

tttcggattc cagaaagttt cagtggggaa gggattgcaa tacctattca taggattatt     1740

gtgagaatga aataaagctt gataatttat gtaaagcctc tagaataggt gcctggtgtg     1800

taataaccac ttaatacttc tgacctgggg atgcctccca aaaaggtttt tttgttgttc     1860

gggttagcat ggtggtgaag agtgtggaag agcaactgct tagattcaaa tccatgttcc     1920

accactttag ataacctctc tttgacttgg tttcctcatc tgcaaaatgg agatgttata     1980

tcaagtattt cagggttgtt atgaggactc aataagctaa tagtgtggaa cattgagaaa     2040

agtacctggc acatcataag cacttgataa aattaatata ctaataatga tgctgataat     2100

tatactgcca ttgttatttc ctgacctgga attcttattt tttttaattt actgaaggct     2160

gggtacagtg gctcacacct gtaatctcag cactttggga ggccaaagca ggcagattgc     2220

ttgagcccag aagttggaga ccagtgaggg caacatagtg agactccatc tctattaaaa     2280

atatatatat tgaaaaattt aaaatttgtt gaaaaaatgt aactgtacaa aacgtgaaag     2340

ttgcctctcc tctaccccaa atcacctttt ttcctcctgc ctcctattct tgactaatgt     2400

tagtgcttca tcatctcatt tttctcctaa tccctttttc caaatatctc ttagcctgag     2460

gtcttcataa cttccatcat cccgcttcat tattacctag ttacttttca tttgtcttag     2520

catcctaatt ccagactcct cattcttcta atttccccag gccaaattcc tgcatccctc     2580

ttcacccctc ttcatctctc tacctccaaa gaggaaaccc ttggagataa gggggttaga     2640

gacaccagta tcacctccct gctcttcctg cctcctcaaa ttgttttctc ttctacttcc     2700

cttttcataa attagctgta atactcctgt tagcaacttt taaaaacagt aaaaaattgt     2760

ctttctcggc cgggcgcggt ggctcacgcc tgtaatccca gcactttggg aggccgaggc     2820

gggtggatca tgaggtcagg agatcgagac catcctggct aacaaggtga aaccccgtct     2880

ctactaaaaa tacaaaaaaa aaattagccg ggcacggtgg cgggcgcctg tagtcccagc     2940

tactcgggag gctgaggcag gagaatggcg tgaacccggg aagcggagct tgcagtgagc     3000

cgagattgcg ccactgcagt ccgcagtccc gcctgggcga cagagcgaga ctccgtctca     3060

aaaaaaaaaa aaaaaaaaaa aaaaaaattg tctttctcat tatataggta tcaaaagtgt     3120

tcagaaacaa atatacagcc tttaagtgga aatagagcta tctggtacta tttttaaaaa     3180

attctaacca tcaagaaaca aaagttcagg attttcttct cttatggaac ttttatttga     3240

aaggaaagta tagaaaagtt ggtctcactt tccagtggac aaattcacca tatcgtcctg     3300

atctgtacca tatgaatgtt aagaatatag attaagttat ctttttcctt gattaaggac     3360

accagtcaat tatatggatt tcccaggact ggtatatgtc tgatagtcac tggcatggct     3420

gtatctgttg ttaaatgtgg agagacttct gtattgggta gtccatagct gctaattgga     3480

gccccaggta atccctgact gacctggttc attccgctgt acccccttga tctggcaact     3540

aaagggttaa cagctggagg cttctgggat ccagcttgag ctggtggtta agtacactga     3600

acatcagccc tggacctctg cagtgccact tattgttcct aaaattctag attaaggcaa     3660

accctttttg gttgtcaaga acatagtgct gtctccaagg aacagcttag tcggtcccac     3720

cagaagcatc tgttgggagc aggttgggca ccaacccttg caggactttg ggatttggga     3780

caatgtagat ttgtgtgagt gcacattaag tctcattgca aaatagaaaa aaaaaagtta     3840

ggaaaaagga gcaagaagtt attcttttaa agtagagact gccttactca tcgtagcacc     3900

tagcacctgg cgtaatgctg gcatatggta tgcacataat taatataaat tgagcgaacg     3960

aatgcaggaa tgggtgcatg cctcctgctt caccatcagg atattcttgt tgggataatg     4020

gtaactcaca tttatatagc agtttagact ttacaatgtg gtgctttgca ccttgtaaat     4080

ttctaatata attccaacat ccttggttac ttccagtttt ccgtctcaca tgtagtccta     4140

cacaaggttt ttttccaaag gagaatatgt agttaattgg ccaagaaatt gcaagctggg     4200

ggaaaaatta taaatactgg gaaataaagg attcttcata gggaacgaaa cagggtttgt     4260

taatgattta tgggaattat gtgaagggcc acattatgca tcaacaatac cctccagcct     4320

atatttcaag cacatgcagt tttttgccgc agtgcttctg ctgcaaagac ctacccccac     4380

ttctcttagc ctgtctgtcc ccactccata cccccgacct ttcatccagc tggcctgtgc     4440

ttgctaaagc tccctttatc ctttcccagc tccctttcca tgttggagta ggttcccccc     4500

ttccatgctc tcatagcacc ctgcaacctt attaggctgt aattattaca tagttagatt     4560

gatctccaac tagattgtca tctctttggt ggagagatta cgttcttgtg tatcttcagt     4620

gcctgacaca gaagtgtttc taaaagtaac atctgcacac ccctcaaaca gaatcacaag     4680

gggcgaggcc aagaaatctg ctctccaagt gataacttaa actttttaac atgctcttca     4740

ggtgacactt aaacttgttt gaaaacctct gtgtcataaa actaaatatt agctggatga     4800

atgtatttgt atctttttct gtgttggcct ttgtgaggag aaatgctgtc tatgcaccaa     4860

atcagagctg aaaaattcta gtgttttgtt aaaaaaaaaa aagagagaga gagagctggg     4920

tttggtggtg catgcctgta gtcccagcta cttgggaagc taagccagga ggactgcttg     4980

agcacaggag ttcaagtcca gcctgggcaa catggtaaga ccccattgct aataaatgaa     5040

taaatttttc tctcaaggtg agagatacta gtactaatac tactactaat aatgagatca     5100

ctgtatgaat tcctttctgt ttctacatta atccctttct gtttctgggt gtgcattttt     5160

gtgtgtaggc ttatctgtct tgggcctctt ttgtcacata ttgctcatct gtgagctgag     5220

gccctgactc actgagtatt tttggggagc agaagaagga gacatttctc tccgaaaatg     5280

aactcaacag gccaccttca ggatgccccc aatgccacct cgctccatgt gcctcactca     5340

caggaaggaa acagcacctc tctccaggag ggtcttcagg atctcatcca cacagccacc     5400

ttggtgacct gtacttttct actggcggtc atcttctgcc tgggttccta tggcaacttc     5460

attgtcttct tgtccttctt cgatccagcc ttcaggaaat tcagaaccaa ctttgatttc     5520

atgatcctga acctgtcctt ctgtgacctc ttcatttgtg gagtgacagc ccccatgttc     5580

acctttgtgt tattcttcag ctcagccagt agtatcccgg atgctttctg cttcactttc     5640

catctcacca gttcaggctt catcatcatg tctctgaaga cagtggcagt gatcgccctg     5700

caccggctcc ggatggtgtt ggggaaacag cctaatcgca cggcctcctt tccctgcacc     5760

gtactcctca ccctgcttct ctgggccacc agtttcaccc ttgccacctt ggctaccttg     5820

aaaaccagca agtcccacct ctgtcttccc atgtccagtc tgattgctgg aaaagggaaa     5880

gccattttgt ctctctatgt ggtcgacttc accttctgtg ttgctgtggt ctctgtctct     5940

tacatcatga ttgctcagac cctgcggaag aacgctcaag tcagaaagtg cccccctgta     6000

atcacagtcg atgcttccag accacagcct ttcatggggg tccctgtgca gggaggtgga     6060

gatcccatcc agtgtgccat gccggctctg tataggaacc agaattacaa caaactgcag     6120

cacgttcaga cccgtggata taccaagagt cccaaccaac tggtcacccc tgcagcaagc     6180

cgactccagc tcgtatcagc catcaacctc tccactgcca aggattccaa agccgtggtc     6240

acctgtgtga tcattgtgct gtcagtcctg gtgtgctgtc ttccactggg gatttccttg     6300

gtacaggtgg ttctctccag caatgggagc ttcattcttt accagtttga attgtttgga     6360

tttactctta tatttttcaa gtcaggatta aaccctttta tatattctcg gaacagtgca     6420

gggctgagaa ggaaagtgct ctggtgcctc caatacatag gcctgggttt tttctgctgc     6480

aaacaaaaga ctcgacttcg agccatggga aaagggaacc tcgaagtcaa cagaaacaaa     6540

tcctcccatc atgaaacaaa ctctgcctac atgttatctc caaagccaca gaagaaattt     6600

gtggaccagg cttgtggccc aagtcattca aaagaaagta tggtgagtcc caagatctct     6660

gctggacatc aacactgtgg tcagagcagc tcgaccccca tcaacactcg gattgaacct     6720

tactacagca tctataacag cagcccttcc caggaggaga gcagcccatg taacttacag     6780

ccagtaaact cttttggatt tgccaattca tatattgcca tgcattatca caccactaat     6840

gacttagtgc aggaatatga cagcacttca gccaagcaga ttccagtccc ctccgtttaa     6900

agtcatggag gctataggat cttatgtaaa cagtttttgt ttctgatagt aatggacttt     6960

attctaactt gagatcagtg gcggatcaaa acctacaaga ttcaactgaa aagttggcag     7020

ttatggtttt ctttcatctg atgtgtcagt atctgttgat ttgctttgta gtttgttgac     7080

atcttaagat ttgatgtgaa agttttagat tttttaccct g                         7121


<210>  2
<211>  540
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Asn Ser Thr Gly His Leu Gln Asp Ala Pro Asn Ala Thr Ser Leu 
1               5                   10                  15      


His Val Pro His Ser Gln Glu Gly Asn Ser Thr Ser Leu Gln Glu Gly 
            20                  25                  30          


Leu Gln Asp Leu Ile His Thr Ala Thr Leu Val Thr Cys Thr Phe Leu 
        35                  40                  45              


Leu Ala Val Ile Phe Cys Leu Gly Ser Tyr Gly Asn Phe Ile Val Phe 
    50                  55                  60                  


Leu Ser Phe Phe Asp Pro Ala Phe Arg Lys Phe Arg Thr Asn Phe Asp 
65                  70                  75                  80  


Phe Met Ile Leu Asn Leu Ser Phe Cys Asp Leu Phe Ile Cys Gly Val 
                85                  90                  95      


Thr Ala Pro Met Phe Thr Phe Val Leu Phe Phe Ser Ser Ala Ser Ser 
            100                 105                 110         


Ile Pro Asp Ala Phe Cys Phe Thr Phe His Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ile Ile Met Ser Leu Lys Thr Val Ala Val Ile Ala Leu His Arg Leu 
    130                 135                 140                 


Arg Met Val Leu Gly Lys Gln Pro Asn Arg Thr Ala Ser Phe Pro Cys 
145                 150                 155                 160 


Thr Val Leu Leu Thr Leu Leu Leu Trp Ala Thr Ser Phe Thr Leu Ala 
                165                 170                 175     


Thr Leu Ala Thr Leu Lys Thr Ser Lys Ser His Leu Cys Leu Pro Met 
            180                 185                 190         


Ser Ser Leu Ile Ala Gly Lys Gly Lys Ala Ile Leu Ser Leu Tyr Val 
        195                 200                 205             


Val Asp Phe Thr Phe Cys Val Ala Val Val Ser Val Ser Tyr Ile Met 
    210                 215                 220                 


Ile Ala Gln Thr Leu Arg Lys Asn Ala Gln Val Arg Lys Cys Pro Pro 
225                 230                 235                 240 


Val Ile Thr Val Asp Ala Ser Arg Pro Gln Pro Phe Met Gly Val Pro 
                245                 250                 255     


Val Gln Gly Gly Gly Asp Pro Ile Gln Cys Ala Met Pro Ala Leu Tyr 
            260                 265                 270         


Arg Asn Gln Asn Tyr Asn Lys Leu Gln His Val Gln Thr Arg Gly Tyr 
        275                 280                 285             


Thr Lys Ser Pro Asn Gln Leu Val Thr Pro Ala Ala Ser Arg Leu Gln 
    290                 295                 300                 


Leu Val Ser Ala Ile Asn Leu Ser Thr Ala Lys Asp Ser Lys Ala Val 
305                 310                 315                 320 


Val Thr Cys Val Ile Ile Val Leu Ser Val Leu Val Cys Cys Leu Pro 
                325                 330                 335     


Leu Gly Ile Ser Leu Val Gln Val Val Leu Ser Ser Asn Gly Ser Phe 
            340                 345                 350         


Ile Leu Tyr Gln Phe Glu Leu Phe Gly Phe Thr Leu Ile Phe Phe Lys 
        355                 360                 365             


Ser Gly Leu Asn Pro Phe Ile Tyr Ser Arg Asn Ser Ala Gly Leu Arg 
    370                 375                 380                 


Arg Lys Val Leu Trp Cys Leu Gln Tyr Ile Gly Leu Gly Phe Phe Cys 
385                 390                 395                 400 


Cys Lys Gln Lys Thr Arg Leu Arg Ala Met Gly Lys Gly Asn Leu Glu 
                405                 410                 415     


Val Asn Arg Asn Lys Ser Ser His His Glu Thr Asn Ser Ala Tyr Met 
            420                 425                 430         


Leu Ser Pro Lys Pro Gln Lys Lys Phe Val Asp Gln Ala Cys Gly Pro 
        435                 440                 445             


Ser His Ser Lys Glu Ser Met Val Ser Pro Lys Ile Ser Ala Gly His 
    450                 455                 460                 


Gln His Cys Gly Gln Ser Ser Ser Thr Pro Ile Asn Thr Arg Ile Glu 
465                 470                 475                 480 


Pro Tyr Tyr Ser Ile Tyr Asn Ser Ser Pro Ser Gln Glu Glu Ser Ser 
                485                 490                 495     


Pro Cys Asn Leu Gln Pro Val Asn Ser Phe Gly Phe Ala Asn Ser Tyr 
            500                 505                 510         


Ile Ala Met His Tyr His Thr Thr Asn Asp Leu Val Gln Glu Tyr Asp 
        515                 520                 525             


Ser Thr Ser Ala Lys Gln Ile Pro Val Pro Ser Val 
    530                 535                 540 


