                         SEQUENCE LISTING

<110>  CHILDREN'S MEDICAL CENTER CORPORATION
 
<120>  METHODS TO TARGET PKD1/PKD2 ION CHANNEL COMPLEX

<130>  C0875.70071WO00

<150>  US 62/306,399
<151>  2016-03-10

<150>  US 62/305,160
<151>  2016-03-08

<160>  48    

<170>  PatentIn version 3.5

<210>  1
<211>  2916
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  1
atggtgaact ccagtcgcgt gcagcctcag cagcccgggg acgccaagcg gccgcccgcg       60

ccccgcgcgc cggacccggg ccggctgatg gctggctgcg cggccgtggg cgccagcctc      120

gccgccccgg gcggcctctg cgagcagcgg ggcctggaga tcgagatgca gcgcatccgg      180

caggcggccg cgcgggaccc cccggccgga gccgcggcct ccccttctcc tccgctctcg      240

tcgtgctccc ggcaggcgtg gagccgcgat aaccccggct tcgaggccga ggaggaggag      300

gaggaggtgg aaggggaaga aggcggaatg gtggtggaga tggacgtaga gtggcgcccg      360

ggcagccgga ggtcggccgc ctcctcggcc gtgagctccg tgggcgcgcg gagccggggg      420

cttgggggct accacggcgc gggccacccg agcgggaggc ggcgccggcg agaggaccag      480

ggcccgccgt gccccagccc agtcggcggc ggggacccgc tgcatcgcca cctccccctg      540

gaagggcagc cgccccgagt ggcctgggcg gagaggctgg ttcgcgggct gcgaggtctc      600

tggggaacaa gactcatgga ggaaagcagc actaaccgag agaaatacct taaaagtgtt      660

ttacgggaac tggtcacata cctccttttt ctcatagtct tgtgcatctt gacctacggc      720

atgatgagct ccaatgtgta ctactacacc cggatgatgt cacagctctt cctagacacc      780

cccgtgtcca aaacggagaa aactaacttt aaaactctgt cttccatgga agacttctgg      840

aagttcacag aaggctcctt attggatggg ctgtactgga agatgcagcc cagcaaccag      900

actgactaca aagacgatga cgacaagagt ttcatcttct atgagaacct gctgttaggg      960

gttccacgaa tacggcaact ccgagtcaga aatggatcct gctctatccc ccaggacttg     1020

agagatgaaa ttaaagagtg ctatgatgtc tactctgtca gtagtgaaga tagggctccc     1080

tttgggcccc gaaatggaac cgcttggatc tacacaagtg aaaaagactt gaatggtagt     1140

agccactggg gaatcattgc aacttatagt ggagctggct attatctgga tttgtcaaga     1200

acaagagagg aaacagctgc acaagttgct agcctcaaga aaaatgtctg gctggaccga     1260

ggaaccaggg caacttttat tgacttctca gtgtacaacg ccaacattaa cctgttctgt     1320

gtggtcaggt tattggttga attcccagca acaggtggtg tgattccatc ttggcaattt     1380

cagcctttaa agctgatccg atatgtcaca acttttgatt tcttcctggc agcctgtgag     1440

attatctttt gtttctttat cttttactat gtggtggaag agatattgga aattcgcatt     1500

cacaaactac actatttcag gagtttctgg aattgtctgg atgttgtgat cgttgtgctg     1560

tcagtggtag ctataggaat taacatatac agaacatcaa atgtggaggt gctactacag     1620

tttctggaag atcaaaatac tttccccaac tttgagcatc tggcatattg gcagatacag     1680

ttcaacaata tagctgctgt cacagtattt tttgtctgga ttaagctctt caaattcatc     1740

aattttaaca ggaccatgag ccagctctcg acaaccatgt ctcgatgtgc caaagacctg     1800

tttggctttg ctattatgtt cttcattatt ttcctagcgt atgctcagtt ggcatacctt     1860

gtctttggca ctcaggtcga tgacttcagt actttccaag agtgtatctt cactcaattc     1920

cgtatcattt tgggcgatat caactttgca gagattgagg aagctaatcg agttttggga     1980

ccaatttatt tcactacatt tgtgttcttt atgttcttca ttcttttgaa tatgtttttg     2040

gctatcatca atgatactta ctctgaagtg aaatctgact tggcacagca gaaagctgaa     2100

atggaactct cagatcttat cagaaagggc taccataaag ctttggtcaa actaaaactg     2160

aaaaaaaata ccgtggatga catttcagag agtctgcggc aaggaggagg caagttaaac     2220

tttgacgaac ttcgacaaga tctcaaaggg aagggccata ctgatgcaga gattgaggca     2280

atattcacaa agtacgacca agatggagac caagaactga ccgaacatga acatcagcag     2340

atgagagacg acttggagaa agagagggag gacctggatt tggatcacag ttctttacca     2400

cgtcccatga gcagccgaag tttccctcga agcctggatg actctgagga ggatgacgat     2460

gaagatagcg gacatagctc cagaaggagg ggaagcattt ctagtggcgt ttcttacgaa     2520

gagtttcaag tcctggtgag acgagtggac cggatggagc attccatcgg cagcatagtg     2580

tccaagattg acgccgtgat cgtgaagcta gagattatgg agcgagccaa actgaagagg     2640

agggaggtgc tgggaaggct gttggatggg gtggccgagg atgaaaggct gggtcgtgac     2700

agtgaaatcc atagggaaca gatggaacgg ctagtacgtg aagagttgga acgctgggaa     2760

tccgatgatg cagcttccca gatcagtcat ggtttaggca cgccagtggg actaaatggt     2820

caacctcgcc ccagaagctc ccgcccatct tcctcccaat ctacagaagg catggaaggt     2880

gcaggtggaa atgggagttc taatgtccac gtatga                               2916


<210>  2
<211>  971
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  2

Met Val Asn Ser Ser Arg Val Gln Pro Gln Gln Pro Gly Asp Ala Lys 
1               5                   10                  15      


Arg Pro Pro Ala Pro Arg Ala Pro Asp Pro Gly Arg Leu Met Ala Gly 
            20                  25                  30          


Cys Ala Ala Val Gly Ala Ser Leu Ala Ala Pro Gly Gly Leu Cys Glu 
        35                  40                  45              


Gln Arg Gly Leu Glu Ile Glu Met Gln Arg Ile Arg Gln Ala Ala Ala 
    50                  55                  60                  


Arg Asp Pro Pro Ala Gly Ala Ala Ala Ser Pro Ser Pro Pro Leu Ser 
65                  70                  75                  80  


Ser Cys Ser Arg Gln Ala Trp Ser Arg Asp Asn Pro Gly Phe Glu Ala 
                85                  90                  95      


Glu Glu Glu Glu Glu Glu Val Glu Gly Glu Glu Gly Gly Met Val Val 
            100                 105                 110         


Glu Met Asp Val Glu Trp Arg Pro Gly Ser Arg Arg Ser Ala Ala Ser 
        115                 120                 125             


Ser Ala Val Ser Ser Val Gly Ala Arg Ser Arg Gly Leu Gly Gly Tyr 
    130                 135                 140                 


His Gly Ala Gly His Pro Ser Gly Arg Arg Arg Arg Arg Glu Asp Gln 
145                 150                 155                 160 


Gly Pro Pro Cys Pro Ser Pro Val Gly Gly Gly Asp Pro Leu His Arg 
                165                 170                 175     


His Leu Pro Leu Glu Gly Gln Pro Pro Arg Val Ala Trp Ala Glu Arg 
            180                 185                 190         


Leu Val Arg Gly Leu Arg Gly Leu Trp Gly Thr Arg Leu Met Glu Glu 
        195                 200                 205             


Ser Ser Thr Asn Arg Glu Lys Tyr Leu Lys Ser Val Leu Arg Glu Leu 
    210                 215                 220                 


Val Thr Tyr Leu Leu Phe Leu Ile Val Leu Cys Ile Leu Thr Tyr Gly 
225                 230                 235                 240 


Met Met Ser Ser Asn Val Tyr Tyr Tyr Thr Arg Met Met Ser Gln Leu 
                245                 250                 255     


Phe Leu Asp Thr Pro Val Ser Lys Thr Glu Lys Thr Asn Phe Lys Thr 
            260                 265                 270         


Leu Ser Ser Met Glu Asp Phe Trp Lys Phe Thr Glu Gly Ser Leu Leu 
        275                 280                 285             


Asp Gly Leu Tyr Trp Lys Met Gln Pro Ser Asn Gln Thr Asp Tyr Lys 
    290                 295                 300                 


Asp Asp Asp Asp Lys Ser Phe Ile Phe Tyr Glu Asn Leu Leu Leu Gly 
305                 310                 315                 320 


Val Pro Arg Ile Arg Gln Leu Arg Val Arg Asn Gly Ser Cys Ser Ile 
                325                 330                 335     


Pro Gln Asp Leu Arg Asp Glu Ile Lys Glu Cys Tyr Asp Val Tyr Ser 
            340                 345                 350         


Val Ser Ser Glu Asp Arg Ala Pro Phe Gly Pro Arg Asn Gly Thr Ala 
        355                 360                 365             


Trp Ile Tyr Thr Ser Glu Lys Asp Leu Asn Gly Ser Ser His Trp Gly 
    370                 375                 380                 


Ile Ile Ala Thr Tyr Ser Gly Ala Gly Tyr Tyr Leu Asp Leu Ser Arg 
385                 390                 395                 400 


Thr Arg Glu Glu Thr Ala Ala Gln Val Ala Ser Leu Lys Lys Asn Val 
                405                 410                 415     


Trp Leu Asp Arg Gly Thr Arg Ala Thr Phe Ile Asp Phe Ser Val Tyr 
            420                 425                 430         


Asn Ala Asn Ile Asn Leu Phe Cys Val Val Arg Leu Leu Val Glu Phe 
        435                 440                 445             


Pro Ala Thr Gly Gly Val Ile Pro Ser Trp Gln Phe Gln Pro Leu Lys 
    450                 455                 460                 


Leu Ile Arg Tyr Val Thr Thr Phe Asp Phe Phe Leu Ala Ala Cys Glu 
465                 470                 475                 480 


Ile Ile Phe Cys Phe Phe Ile Phe Tyr Tyr Val Val Glu Glu Ile Leu 
                485                 490                 495     


Glu Ile Arg Ile His Lys Leu His Tyr Phe Arg Ser Phe Trp Asn Cys 
            500                 505                 510         


Leu Asp Val Val Ile Val Val Leu Ser Val Val Ala Ile Gly Ile Asn 
        515                 520                 525             


Ile Tyr Arg Thr Ser Asn Val Glu Val Leu Leu Gln Phe Leu Glu Asp 
    530                 535                 540                 


Gln Asn Thr Phe Pro Asn Phe Glu His Leu Ala Tyr Trp Gln Ile Gln 
545                 550                 555                 560 


Phe Asn Asn Ile Ala Ala Val Thr Val Phe Phe Val Trp Ile Lys Leu 
                565                 570                 575     


Phe Lys Phe Ile Asn Phe Asn Arg Thr Met Ser Gln Leu Ser Thr Thr 
            580                 585                 590         


Met Ser Arg Cys Ala Lys Asp Leu Phe Gly Phe Ala Ile Met Phe Phe 
        595                 600                 605             


Ile Ile Phe Leu Ala Tyr Ala Gln Leu Ala Tyr Leu Val Phe Gly Thr 
    610                 615                 620                 


Gln Val Asp Asp Phe Ser Thr Phe Gln Glu Cys Ile Phe Thr Gln Phe 
625                 630                 635                 640 


Arg Ile Ile Leu Gly Asp Ile Asn Phe Ala Glu Ile Glu Glu Ala Asn 
                645                 650                 655     


Arg Val Leu Gly Pro Ile Tyr Phe Thr Thr Phe Val Phe Phe Met Phe 
            660                 665                 670         


Phe Ile Leu Leu Asn Met Phe Leu Ala Ile Ile Asn Asp Thr Tyr Ser 
        675                 680                 685             


Glu Val Lys Ser Asp Leu Ala Gln Gln Lys Ala Glu Met Glu Leu Ser 
    690                 695                 700                 


Asp Leu Ile Arg Lys Gly Tyr His Lys Ala Leu Val Lys Leu Lys Leu 
705                 710                 715                 720 


Lys Lys Asn Thr Val Asp Asp Ile Ser Glu Ser Leu Arg Gln Gly Gly 
                725                 730                 735     


Gly Lys Leu Asn Phe Asp Glu Leu Arg Gln Asp Leu Lys Gly Lys Gly 
            740                 745                 750         


His Thr Asp Ala Glu Ile Glu Ala Ile Phe Thr Lys Tyr Asp Gln Asp 
        755                 760                 765             


Gly Asp Gln Glu Leu Thr Glu His Glu His Gln Gln Met Arg Asp Asp 
    770                 775                 780                 


Leu Glu Lys Glu Arg Glu Asp Leu Asp Leu Asp His Ser Ser Leu Pro 
785                 790                 795                 800 


Arg Pro Met Ser Ser Arg Ser Phe Pro Arg Ser Leu Asp Asp Ser Glu 
                805                 810                 815     


Glu Asp Asp Asp Glu Asp Ser Gly His Ser Ser Arg Arg Arg Gly Ser 
            820                 825                 830         


Ile Ser Ser Gly Val Ser Tyr Glu Glu Phe Gln Val Leu Val Arg Arg 
        835                 840                 845             


Val Asp Arg Met Glu His Ser Ile Gly Ser Ile Val Ser Lys Ile Asp 
    850                 855                 860                 


Ala Val Ile Val Lys Leu Glu Ile Met Glu Arg Ala Lys Leu Lys Arg 
865                 870                 875                 880 


Arg Glu Val Leu Gly Arg Leu Leu Asp Gly Val Ala Glu Asp Glu Arg 
                885                 890                 895     


Leu Gly Arg Asp Ser Glu Ile His Arg Glu Gln Met Glu Arg Leu Val 
            900                 905                 910         


Arg Glu Glu Leu Glu Arg Trp Glu Ser Asp Asp Ala Ala Ser Gln Ile 
        915                 920                 925             


Ser His Gly Leu Gly Thr Pro Val Gly Leu Asn Gly Gln Pro Arg Pro 
    930                 935                 940                 


Arg Ser Ser Arg Pro Ser Ser Ser Gln Ser Thr Glu Gly Met Glu Gly 
945                 950                 955                 960 


Ala Gly Gly Asn Gly Ser Ser Asn Val His Val 
                965                 970     


<210>  3
<211>  3870
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  3
atgtacccat acgatgttcc agattacgct caagccgtcg acaacctcac ctctgcgcct       60

ggtaacacca gtctgtgcac cagagactac aaaatcaccc agaccgcctt cggcgccagc      120

ctcttcgtgc ccccaagcca tgtccgcttt gtgtttcctg agccgacagc ggatgtaaac      180

tacatcgtca tgctgacatg tgctgtgtgc ctggtgacct acatggtcat ggccgccatc      240

ctgcacaagc tggaccagtt ggatgccagc cggggccgcg ccatcccttt ctgtgggcag      300

cggggccgct tcaagtacga gatcctcgtc aagacaggct ggggccgggg ctcaggtacc      360

acggcccacg tgggcatcat gctgtatggg gtggacagcc ggagcggcca ccggcacctg      420

gacggcgaca gagccttcca ccgcaacagc ctggacatct tccggatcgc caccccgcac      480

agcctgggta gcgtgtggaa gatccgagtg tggcacgaca acaaagggct cagccctgcc      540

tggttcctgc agcacgtcat cgtcagggac ctgcagacgg cacgcagcgc cttcttcctg      600

gtcaatgact ggctttcggt ggagacggag gccaacgggg gcctggtgga gaaggaggtg      660

ctggccgcga gcgacgcagc ccttttgcgc ttccggcgcc tgctggtggc tgagctgcag      720

cgtggcttct ttgacaagca catctggctc tccatatggg accggccgcc tcgtagccgt      780

ttcactcgca tccagagggc cacctgctgc gttctcctca tctgcctctt cctgggcgcc      840

aacgccgtgt ggtacggggc tgttggcgac tctgcctaca gcacggggca tgtgtccagg      900

ctgagcccgc tgagcgtcga cacagtcgct gttggcctgg tgtccagcgt ggttgtctat      960

cccgtctacc tggccatcct ttttctcttc cggatgtccc ggagcaaggt ggctgggagc     1020

ccgagcccca cacctgccgg gcagcaggtg ctggacatcg acagctgcct ggactcgtcc     1080

gtgctggaca gctccttcct cacgttctca ggcctccacg ctgagcaggc ctttgttgga     1140

cagatgaaga gtgacttgtt tctggatgat tctaagagtc tggtgtgctg gccctccggc     1200

gagggaacgc tcagttggcc ggacctgctc agtgacccgt ccattgtggg tagcaatctg     1260

cggcagctgg cacggggcca ggcgggccat gggctgggcc cagaggagga cggcttctcc     1320

ctggccagcc cctactcgcc tgccaaatcc ttctcagcat cagatgaaga cctgatccag     1380

caggtccttg ccgagggggt cagcagccca gcccctaccc aagacaccca catggaaacg     1440

gacctgctca gcagcctgtc cagcactcct ggggagaaga cagagacgct ggcgctgcag     1500

aggctggggg agctggggcc acccagccca ggcctgaact gggaacagcc ccaggcagcg     1560

aggctgtcca ggacaggact ggtggagggt ctgcggaagc gcctgctgcc ggcctggtgt     1620

gcctccctgg cccacgggct cagcctgctc ctggtggctg tggctgtggc tgtctcaggg     1680

tgggtgggtg cgagcttccc cccgggcgtg agtgttgcgt ggctcctgtc cagcagcgcc     1740

agcttcctgg cctcattcct cggctgggag ccactgaagg tcttgctgga agccctgtac     1800

ttctcactgg tggccaagcg gctgcacccg gatgaagatg acaccctggt agagagcccg     1860

gctgtgacgc ctgtgagcgc acgtgtgccc cgcgtacggc caccccacgg ctttgcactc     1920

ttcctggcca aggaagaagc ccgcaaggtc aagaggctac atggcatgct gcggagcctc     1980

ctggtgtaca tgctttttct gctggtgacc ctgctggcca gctatgggga tgcctcatgc     2040

catgggcacg cctaccgtct gcaaagcgcc atcaagcagg agctgcacag ccgggccttc     2100

ctggccatca cgcggtctga ggagctctgg ccatggatgg cccacgtgct gctgccctac     2160

gtccacggga accagtccag cccagagctg gggcccccac ggctgcggca ggtgcggctg     2220

caggaagcac tctacccaga ccctcccggc cccagggtcc acacgtgctc ggccgcagga     2280

ggcttcagca ccagcgatta cgacgttggc tgggagagtc ctcacaatgg ctcggggacg     2340

tgggcctatt cagcgccgga tctgctgggg gcatggtcct ggggctcctg tgccgtgtat     2400

gacagcgggg gctacgtgca ggagctgggc ctgagcctgg aggagagccg cgaccggctg     2460

cgcttcctgc agctgcacaa ctggctggac aacaggagcc gcgctgtgtt cctggagctc     2520

acgcgctaca gcccggccgt ggggctgcac gccgccgtca cgctgcgcct cgagttcccg     2580

gcggccggcc gcgccctggc cgccctcagc gtccgcccct ttgcgctgcg ccgcctcagc     2640

gcgggcctct cgctgcctct gctcacctcg gtgtgcctgc tgctgttcgc cgtgcacttc     2700

gccgtggccg aggcccgtac ttggcacagg gaagggcgct ggcgcgtgct gcggctcgga     2760

gcctgggcgc ggtggctgct ggtggcgctg acggcggcca cggcactggt acgcctcgcc     2820

cagctgggtg ccgctgaccg ccagtggacc cgtttcgtgc gcggccgccc gcgccgcttc     2880

actagcttcg accaggtggc gcagctgagc tccgcagccc gtggcctggc ggcctcgctg     2940

ctcttcctgc ttttggtcaa ggctgcccag cagctacgct tcgtgcgcca gtggtccgtc     3000

tttggcaaga cattatgccg agctctgcca gagctcctgg gggtcacctt gggcctggtg     3060

gtgctcgggg tagcctacgc ccagctggcc atcctgctcg tgtcttcctg tgtggactcc     3120

ctctggagcg tggcccaggc cctgttggtg ctgtgccctg ggactgggct ctctaccctg     3180

tgtcctgccg agtcctggca cctgtcaccc ctgctgtgtg tggggctctg ggcactgcgg     3240

ctgtggggcg ccctacggct gggggctgtt attctccgct ggcgctacca cgccttgcgt     3300

ggagagctgt accggccggc ctgggagccc caggactacg agatggtgga gttgttcctg     3360

cgcaggctgc gcctctggat gggcctcagc aaggtcaagg agttccgcca caaagtccgc     3420

tttgaaggga tggagccgct gccctctcgc tcctccaggg gctccaaggt atccccggat     3480

gtgcccccac ccagcgctgg ctccgatgcc tcgcacccct ccacctcctc cagccagctg     3540

gatgggctga gcgtgagcct gggccggctg gggacaaggt gtgagcctga gccctcccgc     3600

ctccaagccg tgttcgaggc cctgctcacc cagtttgacc gactcaacca ggccacagag     3660

gacgtctacc agctggagca gcagctgcac agcctgcaag gccgcaggag cagccgggcg     3720

cccgccggat cttcccgtgg cccatccccg ggcctgcggc cagcactgcc cagccgcctt     3780

gcccgggcca gtcggggtgt ggacctggcc actggcccca gcaggacacc ccttcgggcc     3840

aagaacaagg tccaccccag cagcacttag                                      3870


<210>  4
<211>  1289
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  4

Met Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Gln Ala Val Asp Asn Leu 
1               5                   10                  15      


Thr Ser Ala Pro Gly Asn Thr Ser Leu Cys Thr Arg Asp Tyr Lys Ile 
            20                  25                  30          


Thr Gln Thr Ala Phe Gly Ala Ser Leu Phe Val Pro Pro Ser His Val 
        35                  40                  45              


Arg Phe Val Phe Pro Glu Pro Thr Ala Asp Val Asn Tyr Ile Val Met 
    50                  55                  60                  


Leu Thr Cys Ala Val Cys Leu Val Thr Tyr Met Val Met Ala Ala Ile 
65                  70                  75                  80  


Leu His Lys Leu Asp Gln Leu Asp Ala Ser Arg Gly Arg Ala Ile Pro 
                85                  90                  95      


Phe Cys Gly Gln Arg Gly Arg Phe Lys Tyr Glu Ile Leu Val Lys Thr 
            100                 105                 110         


Gly Trp Gly Arg Gly Ser Gly Thr Thr Ala His Val Gly Ile Met Leu 
        115                 120                 125             


Tyr Gly Val Asp Ser Arg Ser Gly His Arg His Leu Asp Gly Asp Arg 
    130                 135                 140                 


Ala Phe His Arg Asn Ser Leu Asp Ile Phe Arg Ile Ala Thr Pro His 
145                 150                 155                 160 


Ser Leu Gly Ser Val Trp Lys Ile Arg Val Trp His Asp Asn Lys Gly 
                165                 170                 175     


Leu Ser Pro Ala Trp Phe Leu Gln His Val Ile Val Arg Asp Leu Gln 
            180                 185                 190         


Thr Ala Arg Ser Ala Phe Phe Leu Val Asn Asp Trp Leu Ser Val Glu 
        195                 200                 205             


Thr Glu Ala Asn Gly Gly Leu Val Glu Lys Glu Val Leu Ala Ala Ser 
    210                 215                 220                 


Asp Ala Ala Leu Leu Arg Phe Arg Arg Leu Leu Val Ala Glu Leu Gln 
225                 230                 235                 240 


Arg Gly Phe Phe Asp Lys His Ile Trp Leu Ser Ile Trp Asp Arg Pro 
                245                 250                 255     


Pro Arg Ser Arg Phe Thr Arg Ile Gln Arg Ala Thr Cys Cys Val Leu 
            260                 265                 270         


Leu Ile Cys Leu Phe Leu Gly Ala Asn Ala Val Trp Tyr Gly Ala Val 
        275                 280                 285             


Gly Asp Ser Ala Tyr Ser Thr Gly His Val Ser Arg Leu Ser Pro Leu 
    290                 295                 300                 


Ser Val Asp Thr Val Ala Val Gly Leu Val Ser Ser Val Val Val Tyr 
305                 310                 315                 320 


Pro Val Tyr Leu Ala Ile Leu Phe Leu Phe Arg Met Ser Arg Ser Lys 
                325                 330                 335     


Val Ala Gly Ser Pro Ser Pro Thr Pro Ala Gly Gln Gln Val Leu Asp 
            340                 345                 350         


Ile Asp Ser Cys Leu Asp Ser Ser Val Leu Asp Ser Ser Phe Leu Thr 
        355                 360                 365             


Phe Ser Gly Leu His Ala Glu Gln Ala Phe Val Gly Gln Met Lys Ser 
    370                 375                 380                 


Asp Leu Phe Leu Asp Asp Ser Lys Ser Leu Val Cys Trp Pro Ser Gly 
385                 390                 395                 400 


Glu Gly Thr Leu Ser Trp Pro Asp Leu Leu Ser Asp Pro Ser Ile Val 
                405                 410                 415     


Gly Ser Asn Leu Arg Gln Leu Ala Arg Gly Gln Ala Gly His Gly Leu 
            420                 425                 430         


Gly Pro Glu Glu Asp Gly Phe Ser Leu Ala Ser Pro Tyr Ser Pro Ala 
        435                 440                 445             


Lys Ser Phe Ser Ala Ser Asp Glu Asp Leu Ile Gln Gln Val Leu Ala 
    450                 455                 460                 


Glu Gly Val Ser Ser Pro Ala Pro Thr Gln Asp Thr His Met Glu Thr 
465                 470                 475                 480 


Asp Leu Leu Ser Ser Leu Ser Ser Thr Pro Gly Glu Lys Thr Glu Thr 
                485                 490                 495     


Leu Ala Leu Gln Arg Leu Gly Glu Leu Gly Pro Pro Ser Pro Gly Leu 
            500                 505                 510         


Asn Trp Glu Gln Pro Gln Ala Ala Arg Leu Ser Arg Thr Gly Leu Val 
        515                 520                 525             


Glu Gly Leu Arg Lys Arg Leu Leu Pro Ala Trp Cys Ala Ser Leu Ala 
    530                 535                 540                 


His Gly Leu Ser Leu Leu Leu Val Ala Val Ala Val Ala Val Ser Gly 
545                 550                 555                 560 


Trp Val Gly Ala Ser Phe Pro Pro Gly Val Ser Val Ala Trp Leu Leu 
                565                 570                 575     


Ser Ser Ser Ala Ser Phe Leu Ala Ser Phe Leu Gly Trp Glu Pro Leu 
            580                 585                 590         


Lys Val Leu Leu Glu Ala Leu Tyr Phe Ser Leu Val Ala Lys Arg Leu 
        595                 600                 605             


His Pro Asp Glu Asp Asp Thr Leu Val Glu Ser Pro Ala Val Thr Pro 
    610                 615                 620                 


Val Ser Ala Arg Val Pro Arg Val Arg Pro Pro His Gly Phe Ala Leu 
625                 630                 635                 640 


Phe Leu Ala Lys Glu Glu Ala Arg Lys Val Lys Arg Leu His Gly Met 
                645                 650                 655     


Leu Arg Ser Leu Leu Val Tyr Met Leu Phe Leu Leu Val Thr Leu Leu 
            660                 665                 670         


Ala Ser Tyr Gly Asp Ala Ser Cys His Gly His Ala Tyr Arg Leu Gln 
        675                 680                 685             


Ser Ala Ile Lys Gln Glu Leu His Ser Arg Ala Phe Leu Ala Ile Thr 
    690                 695                 700                 


Arg Ser Glu Glu Leu Trp Pro Trp Met Ala His Val Leu Leu Pro Tyr 
705                 710                 715                 720 


Val His Gly Asn Gln Ser Ser Pro Glu Leu Gly Pro Pro Arg Leu Arg 
                725                 730                 735     


Gln Val Arg Leu Gln Glu Ala Leu Tyr Pro Asp Pro Pro Gly Pro Arg 
            740                 745                 750         


Val His Thr Cys Ser Ala Ala Gly Gly Phe Ser Thr Ser Asp Tyr Asp 
        755                 760                 765             


Val Gly Trp Glu Ser Pro His Asn Gly Ser Gly Thr Trp Ala Tyr Ser 
    770                 775                 780                 


Ala Pro Asp Leu Leu Gly Ala Trp Ser Trp Gly Ser Cys Ala Val Tyr 
785                 790                 795                 800 


Asp Ser Gly Gly Tyr Val Gln Glu Leu Gly Leu Ser Leu Glu Glu Ser 
                805                 810                 815     


Arg Asp Arg Leu Arg Phe Leu Gln Leu His Asn Trp Leu Asp Asn Arg 
            820                 825                 830         


Ser Arg Ala Val Phe Leu Glu Leu Thr Arg Tyr Ser Pro Ala Val Gly 
        835                 840                 845             


Leu His Ala Ala Val Thr Leu Arg Leu Glu Phe Pro Ala Ala Gly Arg 
    850                 855                 860                 


Ala Leu Ala Ala Leu Ser Val Arg Pro Phe Ala Leu Arg Arg Leu Ser 
865                 870                 875                 880 


Ala Gly Leu Ser Leu Pro Leu Leu Thr Ser Val Cys Leu Leu Leu Phe 
                885                 890                 895     


Ala Val His Phe Ala Val Ala Glu Ala Arg Thr Trp His Arg Glu Gly 
            900                 905                 910         


Arg Trp Arg Val Leu Arg Leu Gly Ala Trp Ala Arg Trp Leu Leu Val 
        915                 920                 925             


Ala Leu Thr Ala Ala Thr Ala Leu Val Arg Leu Ala Gln Leu Gly Ala 
    930                 935                 940                 


Ala Asp Arg Gln Trp Thr Arg Phe Val Arg Gly Arg Pro Arg Arg Phe 
945                 950                 955                 960 


Thr Ser Phe Asp Gln Val Ala Gln Leu Ser Ser Ala Ala Arg Gly Leu 
                965                 970                 975     


Ala Ala Ser Leu Leu Phe Leu Leu Leu Val Lys Ala Ala Gln Gln Leu 
            980                 985                 990         


Arg Phe Val Arg Gln Trp Ser Val  Phe Gly Lys Thr Leu  Cys Arg Ala 
        995                 1000                 1005             


Leu Pro  Glu Leu Leu Gly Val  Thr Leu Gly Leu Val  Val Leu Gly 
    1010                 1015                 1020             


Val Ala  Tyr Ala Gln Leu Ala  Ile Leu Leu Val Ser  Ser Cys Val 
    1025                 1030                 1035             


Asp Ser  Leu Trp Ser Val Ala  Gln Ala Leu Leu Val  Leu Cys Pro 
    1040                 1045                 1050             


Gly Thr  Gly Leu Ser Thr Leu  Cys Pro Ala Glu Ser  Trp His Leu 
    1055                 1060                 1065             


Ser Pro  Leu Leu Cys Val Gly  Leu Trp Ala Leu Arg  Leu Trp Gly 
    1070                 1075                 1080             


Ala Leu  Arg Leu Gly Ala Val  Ile Leu Arg Trp Arg  Tyr His Ala 
    1085                 1090                 1095             


Leu Arg  Gly Glu Leu Tyr Arg  Pro Ala Trp Glu Pro  Gln Asp Tyr 
    1100                 1105                 1110             


Glu Met  Val Glu Leu Phe Leu  Arg Arg Leu Arg Leu  Trp Met Gly 
    1115                 1120                 1125             


Leu Ser  Lys Val Lys Glu Phe  Arg His Lys Val Arg  Phe Glu Gly 
    1130                 1135                 1140             


Met Glu  Pro Leu Pro Ser Arg  Ser Ser Arg Gly Ser  Lys Val Ser 
    1145                 1150                 1155             


Pro Asp  Val Pro Pro Pro Ser  Ala Gly Ser Asp Ala  Ser His Pro 
    1160                 1165                 1170             


Ser Thr  Ser Ser Ser Gln Leu  Asp Gly Leu Ser Val  Ser Leu Gly 
    1175                 1180                 1185             


Arg Leu  Gly Thr Arg Cys Glu  Pro Glu Pro Ser Arg  Leu Gln Ala 
    1190                 1195                 1200             


Val Phe  Glu Ala Leu Leu Thr  Gln Phe Asp Arg Leu  Asn Gln Ala 
    1205                 1210                 1215             


Thr Glu  Asp Val Tyr Gln Leu  Glu Gln Gln Leu His  Ser Leu Gln 
    1220                 1225                 1230             


Gly Arg  Arg Ser Ser Arg Ala  Pro Ala Gly Ser Ser  Arg Gly Pro 
    1235                 1240                 1245             


Ser Pro  Gly Leu Arg Pro Ala  Leu Pro Ser Arg Leu  Ala Arg Ala 
    1250                 1255                 1260             


Ser Arg  Gly Val Asp Leu Ala  Thr Gly Pro Ser Arg  Thr Pro Leu 
    1265                 1270                 1275             


Arg Ala  Lys Asn Lys Val His  Pro Ser Ser Thr 
    1280                 1285                 


<210>  5
<211>  3831
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  5
atgtacccat acgatgttcc agattacgct caagccgtcg acaacctcac ctctgcgcct       60

ggtaacacca gtctgtgcac cagagactac aaaatcaccc aggtccgctt tgtgtttcct      120

gagccgacag cggatgtaaa ctacatcgtc atgctgacat gtgctgtgtg cctggtgacc      180

tacatggtca tggccgccat cctgcacaag ctggaccagt tggatgccag ccggggccgc      240

gccatccctt tctgtgggca gcggggccgc ttcaagtacg agatcctcgt caagacaggc      300

tggggccggg gctcaggtac cacggcccac gtgggcatca tgctgtatgg ggtggacagc      360

cggagcggcc accggcacct ggacggcgac agagccttcc accgcaacag cctggacatc      420

ttccggatcg ccaccccgca cagcctgggt agcgtgtgga agatccgagt gtggcacgac      480

aacaaagggc tcagccctgc ctggttcctg cagcacgtca tcgtcaggga cctgcagacg      540

gcacgcagcg ccttcttcct ggtcaatgac tggctttcgg tggagacgga ggccaacggg      600

ggcctggtgg agaaggaggt gctggccgcg agcgacgcag cccttttgcg cttccggcgc      660

ctgctggtgg ctgagctgca gcgtggcttc tttgacaagc acatctggct ctccatatgg      720

gaccggccgc ctcgtagccg tttcactcgc atccagaggg ccacctgctg cgttctcctc      780

atctgcctct tcctgggcgc caacgccgtg tggtacgggg ctgttggcga ctctgcctac      840

agcacggggc atgtgtccag gctgagcccg ctgagcgtcg acacagtcgc tgttggcctg      900

gtgtccagcg tggttgtcta tcccgtctac ctggccatcc tttttctctt ccggatgtcc      960

cggagcaagg tggctgggag cccgagcccc acacctgccg ggcagcaggt gctggacatc     1020

gacagctgcc tggactcgtc cgtgctggac agctccttcc tcacgttctc aggcctccac     1080

gctgagcagg cctttgttgg acagatgaag agtgacttgt ttctggatga ttctaagagt     1140

ctggtgtgct ggccctccgg cgagggaacg ctcagttggc cggacctgct cagtgacccg     1200

tccattgtgg gtagcaatct gcggcagctg gcacggggcc aggcgggcca tgggctgggc     1260

ccagaggagg acggcttctc cctggccagc ccctactcgc ctgccaaatc cttctcagca     1320

tcagatgaag acctgatcca gcaggtcctt gccgaggggg tcagcagccc agcccctacc     1380

caagacaccc acatggaaac ggacctgctc agcagcctgt ccagcactcc tggggagaag     1440

acagagacgc tggcgctgca gaggctgggg gagctggggc cacccagccc aggcctgaac     1500

tgggaacagc cccaggcagc gaggctgtcc aggacaggac tggtggaggg tctgcggaag     1560

cgcctgctgc cggcctggtg tgcctccctg gcccacgggc tcagcctgct cctggtggct     1620

gtggctgtgg ctgtctcagg gtgggtgggt gcgagcttcc ccccgggcgt gagtgttgcg     1680

tggctcctgt ccagcagcgc cagcttcctg gcctcattcc tcggctggga gccactgaag     1740

gtcttgctgg aagccctgta cttctcactg gtggccaagc ggctgcaccc ggatgaagat     1800

gacaccctgg tagagagccc ggctgtgacg cctgtgagcg cacgtgtgcc ccgcgtacgg     1860

ccaccccacg gctttgcact cttcctggcc aaggaagaag cccgcaaggt caagaggcta     1920

catggcatgc tgcggagcct cctggtgtac atgctttttc tgctggtgac cctgctggcc     1980

agctatgggg atgcctcatg ccatgggcac gcctaccgtc tgcaaagcgc catcaagcag     2040

gagctgcaca gccgggcctt cctggccatc acgcggtctg aggagctctg gccatggatg     2100

gcccacgtgc tgctgcccta cgtccacggg aaccagtcca gcccagagct ggggccccca     2160

cggctgcggc aggtgcggct gcaggaagca ctctacccag accctcccgg ccccagggtc     2220

cacacgtgct cggccgcagg aggcttcagc accagcgatt acgacgttgg ctgggagagt     2280

cctcacaatg gctcggggac gtgggcctat tcagcgccgg atctgctggg ggcatggtcc     2340

tggggctcct gtgccgtgta tgacagcggg ggctacgtgc aggagctggg cctgagcctg     2400

gaggagagcc gcgaccggct gcgcttcctg cagctgcaca actggctgga caacaggagc     2460

cgcgctgtgt tcctggagct cacgcgctac agcccggccg tggggctgca cgccgccgtc     2520

acgctgcgcc tcgagttccc ggcggccggc cgcgccctgg ccgccctcag cgtccgcccc     2580

tttgcgctgc gccgcctcag cgcgggcctc tcgctgcctc tgctcacctc ggtgtgcctg     2640

ctgctgttcg ccgtgcactt cgccgtggcc gaggcccgta cttggcacag ggaagggcgc     2700

tggcgcgtgc tgcggctcgg agcctgggcg cggtggctgc tggtggcgct gacggcggcc     2760

acggcactgg tacgcctcgc ccagctgggt gccgctgacc gccagtggac ccgtttcgtg     2820

cgcggccgcc cgcgccgctt cactagcttc gaccaggtgg cgcagctgag ctccgcagcc     2880

cgtggcctgg cggcctcgct gctcttcctg cttttggtca aggctgccca gcagctacgc     2940

ttcgtgcgcc agtggtccgt ctttggcaag acattatgcc gagctctgcc agagctcctg     3000

ggggtcacct tgggcctggt ggtgctcggg gtagcctacg cccagctggc catcctgctc     3060

gtgtcttcct gtgtggactc cctctggagc gtggcccagg ccctgttggt gctgtgccct     3120

gggactgggc tctctaccct gtgtcctgcc gagtcctggc acctgtcacc cctgctgtgt     3180

gtggggctct gggcactgcg gctgtggggc gccctacggc tgggggctgt tattctccgc     3240

tggcgctacc acgccttgcg tggagagctg taccggccgg cctgggagcc ccaggactac     3300

gagatggtgg agttgttcct gcgcaggctg cgcctctgga tgggcctcag caaggtcaag     3360

gagttccgcc acaaagtccg ctttgaaggg atggagccgc tgccctctcg ctcctccagg     3420

ggctccaagg tatccccgga tgtgccccca cccagcgctg gctccgatgc ctcgcacccc     3480

tccacctcct ccagccagct ggatgggctg agcgtgagcc tgggccggct ggggacaagg     3540

tgtgagcctg agccctcccg cctccaagcc gtgttcgagg ccctgctcac ccagtttgac     3600

cgactcaacc aggccacaga ggacgtctac cagctggagc agcagctgca cagcctgcaa     3660

ggccgcagga gcagccgggc gcccgccgga tcttcccgtg gcccatcccc gggcctgcgg     3720

ccagcactgc ccagccgcct tgcccgggcc agtcggggtg tggacctggc cactggcccc     3780

agcaggacac cccttcgggc caagaacaag gtccacccca gcagcactta g              3831


<210>  6
<211>  1276
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  6

Met Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Gln Ala Val Asp Asn Leu 
1               5                   10                  15      


Thr Ser Ala Pro Gly Asn Thr Ser Leu Cys Thr Arg Asp Tyr Lys Ile 
            20                  25                  30          


Thr Gln Val Arg Phe Val Phe Pro Glu Pro Thr Ala Asp Val Asn Tyr 
        35                  40                  45              


Ile Val Met Leu Thr Cys Ala Val Cys Leu Val Thr Tyr Met Val Met 
    50                  55                  60                  


Ala Ala Ile Leu His Lys Leu Asp Gln Leu Asp Ala Ser Arg Gly Arg 
65                  70                  75                  80  


Ala Ile Pro Phe Cys Gly Gln Arg Gly Arg Phe Lys Tyr Glu Ile Leu 
                85                  90                  95      


Val Lys Thr Gly Trp Gly Arg Gly Ser Gly Thr Thr Ala His Val Gly 
            100                 105                 110         


Ile Met Leu Tyr Gly Val Asp Ser Arg Ser Gly His Arg His Leu Asp 
        115                 120                 125             


Gly Asp Arg Ala Phe His Arg Asn Ser Leu Asp Ile Phe Arg Ile Ala 
    130                 135                 140                 


Thr Pro His Ser Leu Gly Ser Val Trp Lys Ile Arg Val Trp His Asp 
145                 150                 155                 160 


Asn Lys Gly Leu Ser Pro Ala Trp Phe Leu Gln His Val Ile Val Arg 
                165                 170                 175     


Asp Leu Gln Thr Ala Arg Ser Ala Phe Phe Leu Val Asn Asp Trp Leu 
            180                 185                 190         


Ser Val Glu Thr Glu Ala Asn Gly Gly Leu Val Glu Lys Glu Val Leu 
        195                 200                 205             


Ala Ala Ser Asp Ala Ala Leu Leu Arg Phe Arg Arg Leu Leu Val Ala 
    210                 215                 220                 


Glu Leu Gln Arg Gly Phe Phe Asp Lys His Ile Trp Leu Ser Ile Trp 
225                 230                 235                 240 


Asp Arg Pro Pro Arg Ser Arg Phe Thr Arg Ile Gln Arg Ala Thr Cys 
                245                 250                 255     


Cys Val Leu Leu Ile Cys Leu Phe Leu Gly Ala Asn Ala Val Trp Tyr 
            260                 265                 270         


Gly Ala Val Gly Asp Ser Ala Tyr Ser Thr Gly His Val Ser Arg Leu 
        275                 280                 285             


Ser Pro Leu Ser Val Asp Thr Val Ala Val Gly Leu Val Ser Ser Val 
    290                 295                 300                 


Val Val Tyr Pro Val Tyr Leu Ala Ile Leu Phe Leu Phe Arg Met Ser 
305                 310                 315                 320 


Arg Ser Lys Val Ala Gly Ser Pro Ser Pro Thr Pro Ala Gly Gln Gln 
                325                 330                 335     


Val Leu Asp Ile Asp Ser Cys Leu Asp Ser Ser Val Leu Asp Ser Ser 
            340                 345                 350         


Phe Leu Thr Phe Ser Gly Leu His Ala Glu Gln Ala Phe Val Gly Gln 
        355                 360                 365             


Met Lys Ser Asp Leu Phe Leu Asp Asp Ser Lys Ser Leu Val Cys Trp 
    370                 375                 380                 


Pro Ser Gly Glu Gly Thr Leu Ser Trp Pro Asp Leu Leu Ser Asp Pro 
385                 390                 395                 400 


Ser Ile Val Gly Ser Asn Leu Arg Gln Leu Ala Arg Gly Gln Ala Gly 
                405                 410                 415     


His Gly Leu Gly Pro Glu Glu Asp Gly Phe Ser Leu Ala Ser Pro Tyr 
            420                 425                 430         


Ser Pro Ala Lys Ser Phe Ser Ala Ser Asp Glu Asp Leu Ile Gln Gln 
        435                 440                 445             


Val Leu Ala Glu Gly Val Ser Ser Pro Ala Pro Thr Gln Asp Thr His 
    450                 455                 460                 


Met Glu Thr Asp Leu Leu Ser Ser Leu Ser Ser Thr Pro Gly Glu Lys 
465                 470                 475                 480 


Thr Glu Thr Leu Ala Leu Gln Arg Leu Gly Glu Leu Gly Pro Pro Ser 
                485                 490                 495     


Pro Gly Leu Asn Trp Glu Gln Pro Gln Ala Ala Arg Leu Ser Arg Thr 
            500                 505                 510         


Gly Leu Val Glu Gly Leu Arg Lys Arg Leu Leu Pro Ala Trp Cys Ala 
        515                 520                 525             


Ser Leu Ala His Gly Leu Ser Leu Leu Leu Val Ala Val Ala Val Ala 
    530                 535                 540                 


Val Ser Gly Trp Val Gly Ala Ser Phe Pro Pro Gly Val Ser Val Ala 
545                 550                 555                 560 


Trp Leu Leu Ser Ser Ser Ala Ser Phe Leu Ala Ser Phe Leu Gly Trp 
                565                 570                 575     


Glu Pro Leu Lys Val Leu Leu Glu Ala Leu Tyr Phe Ser Leu Val Ala 
            580                 585                 590         


Lys Arg Leu His Pro Asp Glu Asp Asp Thr Leu Val Glu Ser Pro Ala 
        595                 600                 605             


Val Thr Pro Val Ser Ala Arg Val Pro Arg Val Arg Pro Pro His Gly 
    610                 615                 620                 


Phe Ala Leu Phe Leu Ala Lys Glu Glu Ala Arg Lys Val Lys Arg Leu 
625                 630                 635                 640 


His Gly Met Leu Arg Ser Leu Leu Val Tyr Met Leu Phe Leu Leu Val 
                645                 650                 655     


Thr Leu Leu Ala Ser Tyr Gly Asp Ala Ser Cys His Gly His Ala Tyr 
            660                 665                 670         


Arg Leu Gln Ser Ala Ile Lys Gln Glu Leu His Ser Arg Ala Phe Leu 
        675                 680                 685             


Ala Ile Thr Arg Ser Glu Glu Leu Trp Pro Trp Met Ala His Val Leu 
    690                 695                 700                 


Leu Pro Tyr Val His Gly Asn Gln Ser Ser Pro Glu Leu Gly Pro Pro 
705                 710                 715                 720 


Arg Leu Arg Gln Val Arg Leu Gln Glu Ala Leu Tyr Pro Asp Pro Pro 
                725                 730                 735     


Gly Pro Arg Val His Thr Cys Ser Ala Ala Gly Gly Phe Ser Thr Ser 
            740                 745                 750         


Asp Tyr Asp Val Gly Trp Glu Ser Pro His Asn Gly Ser Gly Thr Trp 
        755                 760                 765             


Ala Tyr Ser Ala Pro Asp Leu Leu Gly Ala Trp Ser Trp Gly Ser Cys 
    770                 775                 780                 


Ala Val Tyr Asp Ser Gly Gly Tyr Val Gln Glu Leu Gly Leu Ser Leu 
785                 790                 795                 800 


Glu Glu Ser Arg Asp Arg Leu Arg Phe Leu Gln Leu His Asn Trp Leu 
                805                 810                 815     


Asp Asn Arg Ser Arg Ala Val Phe Leu Glu Leu Thr Arg Tyr Ser Pro 
            820                 825                 830         


Ala Val Gly Leu His Ala Ala Val Thr Leu Arg Leu Glu Phe Pro Ala 
        835                 840                 845             


Ala Gly Arg Ala Leu Ala Ala Leu Ser Val Arg Pro Phe Ala Leu Arg 
    850                 855                 860                 


Arg Leu Ser Ala Gly Leu Ser Leu Pro Leu Leu Thr Ser Val Cys Leu 
865                 870                 875                 880 


Leu Leu Phe Ala Val His Phe Ala Val Ala Glu Ala Arg Thr Trp His 
                885                 890                 895     


Arg Glu Gly Arg Trp Arg Val Leu Arg Leu Gly Ala Trp Ala Arg Trp 
            900                 905                 910         


Leu Leu Val Ala Leu Thr Ala Ala Thr Ala Leu Val Arg Leu Ala Gln 
        915                 920                 925             


Leu Gly Ala Ala Asp Arg Gln Trp Thr Arg Phe Val Arg Gly Arg Pro 
    930                 935                 940                 


Arg Arg Phe Thr Ser Phe Asp Gln Val Ala Gln Leu Ser Ser Ala Ala 
945                 950                 955                 960 


Arg Gly Leu Ala Ala Ser Leu Leu Phe Leu Leu Leu Val Lys Ala Ala 
                965                 970                 975     


Gln Gln Leu Arg Phe Val Arg Gln Trp Ser Val Phe Gly Lys Thr Leu 
            980                 985                 990         


Cys Arg Ala Leu Pro Glu Leu Leu  Gly Val Thr Leu Gly  Leu Val Val 
        995                 1000                 1005             


Leu Gly  Val Ala Tyr Ala Gln  Leu Ala Ile Leu Leu  Val Ser Ser 
    1010                 1015                 1020             


Cys Val  Asp Ser Leu Trp Ser  Val Ala Gln Ala Leu  Leu Val Leu 
    1025                 1030                 1035             


Cys Pro  Gly Thr Gly Leu Ser  Thr Leu Cys Pro Ala  Glu Ser Trp 
    1040                 1045                 1050             


His Leu  Ser Pro Leu Leu Cys  Val Gly Leu Trp Ala  Leu Arg Leu 
    1055                 1060                 1065             


Trp Gly  Ala Leu Arg Leu Gly  Ala Val Ile Leu Arg  Trp Arg Tyr 
    1070                 1075                 1080             


His Ala  Leu Arg Gly Glu Leu  Tyr Arg Pro Ala Trp  Glu Pro Gln 
    1085                 1090                 1095             


Asp Tyr  Glu Met Val Glu Leu  Phe Leu Arg Arg Leu  Arg Leu Trp 
    1100                 1105                 1110             


Met Gly  Leu Ser Lys Val Lys  Glu Phe Arg His Lys  Val Arg Phe 
    1115                 1120                 1125             


Glu Gly  Met Glu Pro Leu Pro  Ser Arg Ser Ser Arg  Gly Ser Lys 
    1130                 1135                 1140             


Val Ser  Pro Asp Val Pro Pro  Pro Ser Ala Gly Ser  Asp Ala Ser 
    1145                 1150                 1155             


His Pro  Ser Thr Ser Ser Ser  Gln Leu Asp Gly Leu  Ser Val Ser 
    1160                 1165                 1170             


Leu Gly  Arg Leu Gly Thr Arg  Cys Glu Pro Glu Pro  Ser Arg Leu 
    1175                 1180                 1185             


Gln Ala  Val Phe Glu Ala Leu  Leu Thr Gln Phe Asp  Arg Leu Asn 
    1190                 1195                 1200             


Gln Ala  Thr Glu Asp Val Tyr  Gln Leu Glu Gln Gln  Leu His Ser 
    1205                 1210                 1215             


Leu Gln  Gly Arg Arg Ser Ser  Arg Ala Pro Ala Gly  Ser Ser Arg 
    1220                 1225                 1230             


Gly Pro  Ser Pro Gly Leu Arg  Pro Ala Leu Pro Ser  Arg Leu Ala 
    1235                 1240                 1245             


Arg Ala  Ser Arg Gly Val Asp  Leu Ala Thr Gly Pro  Ser Arg Thr 
    1250                 1255                 1260             


Pro Leu  Arg Ala Lys Asn Lys  Val His Pro Ser Ser  Thr 
    1265                 1270                 1275     


<210>  7
<211>  2058
<212>  DNA
<213>  Homo sapiens

<400>  7
atgaagcggc tgcacccgga tgaagatgac accctggtag agagcccggc tgtgacgcct       60

gtgagcgcac gtgtgccccg cgtacggcca ccccacggct ttgcactctt cctggccaag      120

gaagaagccc gcaaggtcaa gaggctacat ggcatgctgc ggagcctcct ggtgtacatg      180

ctttttctgc tggtgaccct gctggccagc tatggggatg cctcatgcca tgggcacgcc      240

taccgtctgc aaagcgccat caagcaggag ctgcacagcc gggccttcct ggccatcacg      300

cggtctgagg agctctggcc atggatggcc cacgtgctgc tgccctacgt ccacgggaac      360

cagtccagcc cagagctggg gcccccacgg ctgcggcagg tgcggctgca ggaagcactc      420

tacccagacc ctcccggccc cagggtccac acgtgctcgg ccgcaggagg cttcagcacc      480

agcgattacg acgttggctg ggagagtcct cacaatggct cggggacgtg ggcctattca      540

gcgccggatc tgctgggggc atggtcctgg ggctcctgtg ccgtgtatga cagcgggggc      600

tacgtgcagg agctgggcct gagcctggag gagagccgcg accggctgcg cttcctgcag      660

ctgcacaact ggctggacaa caggagccgc gctgtgttcc tggagctcac gcgctacagc      720

ccggccgtgg ggctgcacgc cgccgtcacg ctgcgcctcg agttcccggc ggccggccgc      780

gccctggccg ccctcagcgt ccgccccttt gcgctgcgcc gcctcagcgc gggcctctcg      840

ctgcctctgc tcacctcggt gtgcctgctg ctgttcgccg tgcacttcgc cgtggccgag      900

gcccgtactt ggcacaggga agggcgctgg cgcgtgctgc ggctcggagc ctgggcgcgg      960

tggctgctgg tggcgctgac ggcggccacg gcactggtac gcctcgccca gctgggtgcc     1020

gctgaccgcc agtggacccg tttcgtgcgc ggccgcccgc gccgcttcac tagcttcgac     1080

caggtggcgc agctgagctc cgcagcccgt ggcctggcgg cctcgctgct cttcctgctt     1140

ttggtcaagg ctgcccagca gctacgcttc gtgcgccagt ggtccgtctt tggcaagaca     1200

ttatgccgag ctctgccaga gctcctgggg gtcaccttgg gcctggtggt gctcggggta     1260

gcctacgccc agctggccat cctgctcgtg tcttcctgtg tggactccct ctggagcgtg     1320

gcccaggccc tgttggtgct gtgccctggg actgggctct ctaccctgtg tcctgccgag     1380

tcctggcacc tgtcacccct gctgtgtgtg gggctctggg cactgcggct gtggggcgcc     1440

ctacggctgg gggctgttat tctccgctgg cgctaccacg ccttgcgtgg agagctgtac     1500

cggccggcct gggagcccca ggactacgag atggtggagt tgttcctgcg caggctgcgc     1560

ctctggatgg gcctcagcaa ggtcaaggag ttccgccaca aagtccgctt tgaagggatg     1620

gagccgctgc cctctcgctc ctccaggggc tccaaggtat ccccggatgt gcccccaccc     1680

agcgctggct ccgatgcctc gcacccctcc acctcctcca gccagctgga tgggctgagc     1740

gtgagcctgg gccggctggg gacaaggtgt gagcctgagc cctcccgcct ccaagccgtg     1800

ttcgaggccc tgctcaccca gtttgaccga ctcaaccagg ccacagagga cgtctaccag     1860

ctggagcagc agctgcacag cctgcaaggc cgcaggagca gccgggcgcc cgccggatct     1920

tcccgtggcc catccccggg cctgcggcca gcactgccca gccgccttgc ccgggccagt     1980

cggggtgtgg acctggccac tggccccagc aggacacccc ttcgggccaa gaacaaggtc     2040

caccccagca gcacttag                                                   2058


<210>  8
<211>  685
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Lys Arg Leu His Pro Asp Glu Asp Asp Thr Leu Val Glu Ser Pro 
1               5                   10                  15      


Ala Val Thr Pro Val Ser Ala Arg Val Pro Arg Val Arg Pro Pro His 
            20                  25                  30          


Gly Phe Ala Leu Phe Leu Ala Lys Glu Glu Ala Arg Lys Val Lys Arg 
        35                  40                  45              


Leu His Gly Met Leu Arg Ser Leu Leu Val Tyr Met Leu Phe Leu Leu 
    50                  55                  60                  


Val Thr Leu Leu Ala Ser Tyr Gly Asp Ala Ser Cys His Gly His Ala 
65                  70                  75                  80  


Tyr Arg Leu Gln Ser Ala Ile Lys Gln Glu Leu His Ser Arg Ala Phe 
                85                  90                  95      


Leu Ala Ile Thr Arg Ser Glu Glu Leu Trp Pro Trp Met Ala His Val 
            100                 105                 110         


Leu Leu Pro Tyr Val His Gly Asn Gln Ser Ser Pro Glu Leu Gly Pro 
        115                 120                 125             


Pro Arg Leu Arg Gln Val Arg Leu Gln Glu Ala Leu Tyr Pro Asp Pro 
    130                 135                 140                 


Pro Gly Pro Arg Val His Thr Cys Ser Ala Ala Gly Gly Phe Ser Thr 
145                 150                 155                 160 


Ser Asp Tyr Asp Val Gly Trp Glu Ser Pro His Asn Gly Ser Gly Thr 
                165                 170                 175     


Trp Ala Tyr Ser Ala Pro Asp Leu Leu Gly Ala Trp Ser Trp Gly Ser 
            180                 185                 190         


Cys Ala Val Tyr Asp Ser Gly Gly Tyr Val Gln Glu Leu Gly Leu Ser 
        195                 200                 205             


Leu Glu Glu Ser Arg Asp Arg Leu Arg Phe Leu Gln Leu His Asn Trp 
    210                 215                 220                 


Leu Asp Asn Arg Ser Arg Ala Val Phe Leu Glu Leu Thr Arg Tyr Ser 
225                 230                 235                 240 


Pro Ala Val Gly Leu His Ala Ala Val Thr Leu Arg Leu Glu Phe Pro 
                245                 250                 255     


Ala Ala Gly Arg Ala Leu Ala Ala Leu Ser Val Arg Pro Phe Ala Leu 
            260                 265                 270         


Arg Arg Leu Ser Ala Gly Leu Ser Leu Pro Leu Leu Thr Ser Val Cys 
        275                 280                 285             


Leu Leu Leu Phe Ala Val His Phe Ala Val Ala Glu Ala Arg Thr Trp 
    290                 295                 300                 


His Arg Glu Gly Arg Trp Arg Val Leu Arg Leu Gly Ala Trp Ala Arg 
305                 310                 315                 320 


Trp Leu Leu Val Ala Leu Thr Ala Ala Thr Ala Leu Val Arg Leu Ala 
                325                 330                 335     


Gln Leu Gly Ala Ala Asp Arg Gln Trp Thr Arg Phe Val Arg Gly Arg 
            340                 345                 350         


Pro Arg Arg Phe Thr Ser Phe Asp Gln Val Ala Gln Leu Ser Ser Ala 
        355                 360                 365             


Ala Arg Gly Leu Ala Ala Ser Leu Leu Phe Leu Leu Leu Val Lys Ala 
    370                 375                 380                 


Ala Gln Gln Leu Arg Phe Val Arg Gln Trp Ser Val Phe Gly Lys Thr 
385                 390                 395                 400 


Leu Cys Arg Ala Leu Pro Glu Leu Leu Gly Val Thr Leu Gly Leu Val 
                405                 410                 415     


Val Leu Gly Val Ala Tyr Ala Gln Leu Ala Ile Leu Leu Val Ser Ser 
            420                 425                 430         


Cys Val Asp Ser Leu Trp Ser Val Ala Gln Ala Leu Leu Val Leu Cys 
        435                 440                 445             


Pro Gly Thr Gly Leu Ser Thr Leu Cys Pro Ala Glu Ser Trp His Leu 
    450                 455                 460                 


Ser Pro Leu Leu Cys Val Gly Leu Trp Ala Leu Arg Leu Trp Gly Ala 
465                 470                 475                 480 


Leu Arg Leu Gly Ala Val Ile Leu Arg Trp Arg Tyr His Ala Leu Arg 
                485                 490                 495     


Gly Glu Leu Tyr Arg Pro Ala Trp Glu Pro Gln Asp Tyr Glu Met Val 
            500                 505                 510         


Glu Leu Phe Leu Arg Arg Leu Arg Leu Trp Met Gly Leu Ser Lys Val 
        515                 520                 525             


Lys Glu Phe Arg His Lys Val Arg Phe Glu Gly Met Glu Pro Leu Pro 
    530                 535                 540                 


Ser Arg Ser Ser Arg Gly Ser Lys Val Ser Pro Asp Val Pro Pro Pro 
545                 550                 555                 560 


Ser Ala Gly Ser Asp Ala Ser His Pro Ser Thr Ser Ser Ser Gln Leu 
                565                 570                 575     


Asp Gly Leu Ser Val Ser Leu Gly Arg Leu Gly Thr Arg Cys Glu Pro 
            580                 585                 590         


Glu Pro Ser Arg Leu Gln Ala Val Phe Glu Ala Leu Leu Thr Gln Phe 
        595                 600                 605             


Asp Arg Leu Asn Gln Ala Thr Glu Asp Val Tyr Gln Leu Glu Gln Gln 
    610                 615                 620                 


Leu His Ser Leu Gln Gly Arg Arg Ser Ser Arg Ala Pro Ala Gly Ser 
625                 630                 635                 640 


Ser Arg Gly Pro Ser Pro Gly Leu Arg Pro Ala Leu Pro Ser Arg Leu 
                645                 650                 655     


Ala Arg Ala Ser Arg Gly Val Asp Leu Ala Thr Gly Pro Ser Arg Thr 
            660                 665                 670         


Pro Leu Arg Ala Lys Asn Lys Val His Pro Ser Ser Thr 
        675                 680                 685 


<210>  9
<211>  102
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  9
atgtacccat acgatgttcc agattacgct caagccgtcg acaacctcac ctctgcgcct       60

ggtaacacca gtctgtgcac cagagactac aaaatcaccc ag                         102


<210>  10
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  10

Met Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Gln Ala Val Asp Asn Leu 
1               5                   10                  15      


Thr Ser Ala Pro Gly Asn Thr Ser Leu Cys Thr Arg Asp Tyr Lys Ile 
            20                  25                  30          


Thr Gln 
        


<210>  11
<211>  963
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Val Asn Ser Ser Arg Val Gln Pro Gln Gln Pro Gly Asp Ala Lys 
1               5                   10                  15      


Arg Pro Pro Ala Pro Arg Ala Pro Asp Pro Gly Arg Leu Met Ala Gly 
            20                  25                  30          


Cys Ala Ala Val Gly Ala Ser Leu Ala Ala Pro Gly Gly Leu Cys Glu 
        35                  40                  45              


Gln Arg Gly Leu Glu Ile Glu Met Gln Arg Ile Arg Gln Ala Ala Ala 
    50                  55                  60                  


Arg Asp Pro Pro Ala Gly Ala Ala Ala Ser Pro Ser Pro Pro Leu Ser 
65                  70                  75                  80  


Ser Cys Ser Arg Gln Ala Trp Ser Arg Asp Asn Pro Gly Phe Glu Ala 
                85                  90                  95      


Glu Glu Glu Glu Glu Glu Val Glu Gly Glu Glu Gly Gly Met Val Val 
            100                 105                 110         


Glu Met Asp Val Glu Trp Arg Pro Gly Ser Arg Arg Ser Ala Ala Ser 
        115                 120                 125             


Ser Ala Val Ser Ser Val Gly Ala Arg Ser Arg Gly Leu Gly Gly Tyr 
    130                 135                 140                 


His Gly Ala Gly His Pro Ser Gly Arg Arg Arg Arg Arg Glu Asp Gln 
145                 150                 155                 160 


Gly Pro Pro Cys Pro Ser Pro Val Gly Gly Gly Asp Pro Leu His Arg 
                165                 170                 175     


His Leu Pro Leu Glu Gly Gln Pro Pro Arg Val Ala Trp Ala Glu Arg 
            180                 185                 190         


Leu Val Arg Gly Leu Arg Gly Leu Trp Gly Thr Arg Leu Met Glu Glu 
        195                 200                 205             


Ser Ser Thr Asn Arg Glu Lys Tyr Leu Lys Ser Val Leu Arg Glu Leu 
    210                 215                 220                 


Val Thr Tyr Leu Leu Phe Leu Ile Val Leu Cys Ile Leu Thr Tyr Gly 
225                 230                 235                 240 


Met Met Ser Ser Asn Val Tyr Tyr Tyr Thr Arg Met Met Ser Gln Leu 
                245                 250                 255     


Phe Leu Asp Thr Pro Val Ser Lys Thr Glu Lys Thr Asn Phe Lys Thr 
            260                 265                 270         


Leu Ser Ser Met Glu Asp Phe Trp Lys Phe Thr Glu Gly Ser Leu Leu 
        275                 280                 285             


Asp Gly Leu Tyr Trp Lys Met Gln Pro Ser Asn Gln Thr Ser Phe Ile 
    290                 295                 300                 


Phe Tyr Glu Asn Leu Leu Leu Gly Val Pro Arg Ile Arg Gln Leu Arg 
305                 310                 315                 320 


Val Arg Asn Gly Ser Cys Ser Ile Pro Gln Asp Leu Arg Asp Glu Ile 
                325                 330                 335     


Lys Glu Cys Tyr Asp Val Tyr Ser Val Ser Ser Glu Asp Arg Ala Pro 
            340                 345                 350         


Phe Gly Pro Arg Asn Gly Thr Ala Trp Ile Tyr Thr Ser Glu Lys Asp 
        355                 360                 365             


Leu Asn Gly Ser Ser His Trp Gly Ile Ile Ala Thr Tyr Ser Gly Ala 
    370                 375                 380                 


Gly Tyr Tyr Leu Asp Leu Ser Arg Thr Arg Glu Glu Thr Ala Ala Gln 
385                 390                 395                 400 


Val Ala Ser Leu Lys Lys Asn Val Trp Leu Asp Arg Gly Thr Arg Ala 
                405                 410                 415     


Thr Phe Ile Asp Phe Ser Val Tyr Asn Ala Asn Ile Asn Leu Phe Cys 
            420                 425                 430         


Val Val Arg Leu Leu Val Glu Phe Pro Ala Thr Gly Gly Val Ile Pro 
        435                 440                 445             


Ser Trp Gln Phe Gln Pro Leu Lys Leu Ile Arg Tyr Val Thr Thr Phe 
    450                 455                 460                 


Asp Phe Phe Leu Ala Ala Cys Glu Ile Ile Phe Cys Phe Phe Ile Phe 
465                 470                 475                 480 


Tyr Tyr Val Val Glu Glu Ile Leu Glu Ile Arg Ile His Lys Leu His 
                485                 490                 495     


Tyr Phe Arg Ser Phe Trp Asn Cys Leu Asp Val Val Ile Val Val Leu 
            500                 505                 510         


Ser Val Val Ala Ile Gly Ile Asn Ile Tyr Arg Thr Ser Asn Val Glu 
        515                 520                 525             


Val Leu Leu Gln Phe Leu Glu Asp Gln Asn Thr Phe Pro Asn Phe Glu 
    530                 535                 540                 


His Leu Ala Tyr Trp Gln Ile Gln Phe Asn Asn Ile Ala Ala Val Thr 
545                 550                 555                 560 


Val Phe Phe Val Trp Ile Lys Leu Phe Lys Phe Ile Asn Phe Asn Arg 
                565                 570                 575     


Thr Met Ser Gln Leu Ser Thr Thr Met Ser Arg Cys Ala Lys Asp Leu 
            580                 585                 590         


Phe Gly Phe Ala Ile Met Phe Phe Ile Ile Phe Leu Ala Tyr Ala Gln 
        595                 600                 605             


Leu Ala Tyr Leu Val Phe Gly Thr Gln Val Asp Asp Phe Ser Thr Phe 
    610                 615                 620                 


Gln Glu Cys Ile Phe Thr Gln Phe Arg Ile Ile Leu Gly Asp Ile Asn 
625                 630                 635                 640 


Phe Ala Glu Ile Glu Glu Ala Asn Arg Val Leu Gly Pro Ile Tyr Phe 
                645                 650                 655     


Thr Thr Phe Val Phe Phe Met Phe Phe Ile Leu Leu Asn Met Phe Leu 
            660                 665                 670         


Ala Ile Ile Asn Asp Thr Tyr Ser Glu Val Lys Ser Asp Leu Ala Gln 
        675                 680                 685             


Gln Lys Ala Glu Met Glu Leu Ser Asp Leu Ile Arg Lys Gly Tyr His 
    690                 695                 700                 


Lys Ala Leu Val Lys Leu Lys Leu Lys Lys Asn Thr Val Asp Asp Ile 
705                 710                 715                 720 


Ser Glu Ser Leu Arg Gln Gly Gly Gly Lys Leu Asn Phe Asp Glu Leu 
                725                 730                 735     


Arg Gln Asp Leu Lys Gly Lys Gly His Thr Asp Ala Glu Ile Glu Ala 
            740                 745                 750         


Ile Phe Thr Lys Tyr Asp Gln Asp Gly Asp Gln Glu Leu Thr Glu His 
        755                 760                 765             


Glu His Gln Gln Met Arg Asp Asp Leu Glu Lys Glu Arg Glu Asp Leu 
    770                 775                 780                 


Asp Leu Asp His Ser Ser Leu Pro Arg Pro Met Ser Ser Arg Ser Phe 
785                 790                 795                 800 


Pro Arg Ser Leu Asp Asp Ser Glu Glu Asp Asp Asp Glu Asp Ser Gly 
                805                 810                 815     


His Ser Ser Arg Arg Arg Gly Ser Ile Ser Ser Gly Val Ser Tyr Glu 
            820                 825                 830         


Glu Phe Gln Val Leu Val Arg Arg Val Asp Arg Met Glu His Ser Ile 
        835                 840                 845             


Gly Ser Ile Val Ser Lys Ile Asp Ala Val Ile Val Lys Leu Glu Ile 
    850                 855                 860                 


Met Glu Arg Ala Lys Leu Lys Arg Arg Glu Val Leu Gly Arg Leu Leu 
865                 870                 875                 880 


Asp Gly Val Ala Glu Asp Glu Arg Leu Gly Arg Asp Ser Glu Ile His 
                885                 890                 895     


Arg Glu Gln Met Glu Arg Leu Val Arg Glu Glu Leu Glu Arg Trp Glu 
            900                 905                 910         


Ser Asp Asp Ala Ala Ser Gln Ile Ser His Gly Leu Gly Thr Pro Val 
        915                 920                 925             


Gly Leu Asn Gly Gln Pro Arg Pro Arg Ser Ser Arg Pro Ser Ser Ser 
    930                 935                 940                 


Gln Ser Thr Glu Gly Met Glu Gly Ala Gly Gly Asn Gly Ser Ser Asn 
945                 950                 955                 960 


Val His Val 
            


<210>  12
<211>  2881
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  12
agcgatctga cggttcacta aacgagctct gcttatatag gcctcccacc gtacacgcca       60

cctcgacata ctcgagttta ctccctatca gtgatagaga acgtatgaag agtttactcc      120

ctatcagtga tagagaacgt atgcagactt tactccctat cagtgataga gaacgtataa      180

ggagtttact ccctatcagt gatagagaac gtatgaccag tttactccct atcagtgata      240

gagaacgtat ctacagttta ctccctatca gtgatagaga acgtatatcc agtttactcc      300

ctatcagtga tagagaacgt ataagcttta ggcgtgtacg gtgggcgcct ataaaagcag      360

agctcgttta gtgaaccgtc agatcgcctg gagcaattcc acaacacttt tgtcttatac      420

caactttccg taccacttcc taccctcgta aagtcgacac cggggcccag atctccgcgg      480

ggatccatcg atccgcggcc gccggcgata tctccagagg atcataatca gccataccac      540

atttgtagag gttttacttg ctttaaaaaa cctcccacac ctccccctga acctgaaaca      600

taaaatgaat gcaattgttg ttgttaactt gtttattgca gcttataatg gttacaaata      660

aagcaatagc atcacaaatt tcacaaataa agcatttttt tcactgcccc gagcttcctc      720

gctcactgac tcgctgcgct cggtcgttcg gctgcggcga gcggtatcag ctcactcaaa      780

ggcggtaata cggttatcca cagaatcagg ggataacgca ggaaagaaca tgtgagcaaa      840

aggccagcaa aaggccagga accgtaaaaa ggccgcgttg ctggcgtttt tccataggct      900

ccgcccccct gacgagcatc acaaaaatcg acgctcaagt cagaggtggc gaaacccgac      960

aggactataa agataccagg cgtttccccc tggaagctcc ctcgtgcgct ctcctgttcc     1020

gaccctgccg cttaccggat acctgtccgc ctttctccct tcgggaagcg tggcgctttc     1080

tcaatgctca cgctgtaggt atctcagttc ggtgtaggtc gttcgctcca agctgggctg     1140

tgtgcacgaa ccccccgttc agcccgaccg ctgcgcctta tccggtaact atcgtcttga     1200

gtccaacccg gtaagacacg acttatcgcc actggcagca gccactggta acaggattag     1260

cagagcgagg tatgtaggcg gtgctacaga gttcttgaag tggtggccta actacggcta     1320

cactagaagg acagtatttg gtatctgcgc tctgctgaag ccagttacct tcggaaaaag     1380

agttggtagc tcttgatccg gcaaacaaac caccgctggt agcggtggtt tttttgtttg     1440

caagcagcag attacgcgca gaaaaaaagg atctcaagaa gatcctttga tcttttctac     1500

ggggtctgac gctcagtgga acgaaaactc acgttaaggg attttggtca tgagattatc     1560

aaaaaggatc ttcacctaga tccttttaaa ttaaaaatga agttttaaat caatctaaag     1620

tatatatgag taaacttggt ctgacagtta ccaatgctta atcagtgagg cacctatctc     1680

agcgatctgt ctatttcgtt catccatagt tgcctgactc cccgtcgtgt agataactac     1740

gatacgggag ggcttaccat ctggccccag tgctgcaatg ataccgcgag acccacgctc     1800

accggctcca gatttatcag caataaacca gccagccgga agggccgagc gcagaagtgg     1860

tcctgcaact ttatccgcct ccatccagtc tattaattgt tgccgggaag ctagagtaag     1920

tagttcgcca gttaatagtt tgcgcaacgt tgttgccatt gctacaggca tcgtggtgtc     1980

acgctcgtcg tttggtatgg cttcattcag ctccggttcc caacgatcaa ggcgagttac     2040

atgatccccc atgttgtgca aaaaagcggt tagctccttc ggtcctccga tcgttgtcag     2100

aagtaagttg gccgcagtgt tatcactcat ggttatggca gcactgcata attctcttac     2160

tgtcatgcca tccgtaagat gcttttctgt gactggtgag tactcaacca agtcattctg     2220

agaatagtgt atgcggcgac cgagttgctc ttgcccggcg tcaatacggg ataataccgc     2280

gccacatagc agaactttaa aagtgctcat cattggaaaa cgttcttcgg ggcgaaaact     2340

ctcaaggatc ttaccgctgt tgagatccag ttcgatgtaa cccactcgtg cacccaactg     2400

atcttcagca tcttttactt tcaccagcgt ttctgggtga gcaaaaacag gaaggcaaaa     2460

tgccgcaaaa aagggaataa gggcgacacg gaaatgttga atactcatac tcttcctttt     2520

tcaatattat tgaagcattt atcagggtta ttgtctcatg agcggataca tatttgaatg     2580

tatttagaaa aataaacaaa taggggttcc gcgcacattt ccccgaaaag tgccacctga     2640

cgtcggcagt gaaaaaaatg ctttatttgt gaaatttgtg atgctattgc tttatttgta     2700

accattataa gctgcaataa acaagttaac aacaacaatt gcattcattt tatgtttcag     2760

gttcaggggg aggtgtggga ggttttttaa agcaagtaaa acctctacaa atgtggtatg     2820

gctgattatg atcctctaga catatgctgc agacgcgtgg tacccccggg gaattctcca     2880

g                                                                     2881


<210>  13
<211>  5297
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  13
tagttattaa tagtaatcaa ttacggggtc attagttcat agcccatata tggagttccg       60

cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc cccgcccatt      120

gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc attgacgtca      180

atgggtggag tatttacggt aaactgccca cttggcagta catcaagtgt atcatatgcc      240

aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt atgcccagta      300

catgacctta tgggactttc ctacttggca gtacatctac gtattagtca tcgctattac      360

catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg actcacgggg      420

atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc aaaatcaacg      480

ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg gtaggcgtgt      540

acggtgggag gtctatataa gcagagctgg tttagtgaac cgtcagatcc gctagcgcta      600

ccggactcag atctcgagct caagcttcga attctgcagt cgacggtacc gcggcgctac      660

gtaaattccg cccccccccc ccctaacgtt actggccgaa gccgcttgga ataaggccgg      720

tgtgcgtttg tctatatgtt attttccacc atattgccgt cttttggcaa tgtgagggcc      780

cggaaacctg gccctgtctt cttgacgagc attcctaggg gtctttcccc tcycgccaaa      840

ggaatgcaag gtctgttgaa tgtcgtgaag gaagcagttc ctctggaagc ttcttgaaga      900

caaacaacgt ctgtagcgac cctttgcagg cagcggaacc ccccacctgg cgacaggtgc      960

ctctgcggcc aaaagccacg tgtatmagat acacctgcaa aggcggcaca accccagtgc     1020

cacgttgtga gttggatagt tgtggaaaga gtcaaatggc tctcctcaag cgtattcaac     1080

aaggggctga aggatgccca gaaggtaccc cattgtatgg gatctgatct ggggcctcgr     1140

trcacatgct ttacatgtgt ttagtcgagg ttaaaaaaac gtctaggccc cccgaaccac     1200

ggggacgtgg ttttcctttg aaaaacacga tgataatatg gccamaamma wratggtgag     1260

caagggcgag gaggataaca tggccatcat caaggagttc atgcgcttca aggtgcacat     1320

ggagggctcc gtgaacggcc acgagttcga gatcgagggc gagggcgagg gccgccccta     1380

cgagggcacc cagaccgcca agctgaaggt gaccaagggt ggccccctgc ccttcgcctg     1440

ggacatcctg tcccctcagt tcatgtacgg ctccaaggcc tacgtgaagc accccgccga     1500

catccccgac tacttgaagc tgtccttccc cgagggcttc aagtgggagc gcgtgatgaa     1560

cttcgaggac ggcggcgtgg tgaccgtgac ccaggactcc tccctgcagg acggcgagtt     1620

catctacaag gtgaagctgc gcggcaccaa cttcccctcc gacggccccg taatgcagaa     1680

gaagaccatg ggctgggagg cctcctccga gcggatgtac cccgaggacg gcgccctgaa     1740

gggcgagatc aagcagaggc tgaagctgaa ggacggcggc cactacgacg ctgaggtcaa     1800

gaccacctac aaggccaaga agcccgtgca gctgcccggc gcctacaacg tcaacatcaa     1860

gttggacatc acctcccaca acgaggacta caccatcgtg gaacagtacg aacgcgccga     1920

gggccgccac tccaccggcg gcatggacga gctgtacaag taagcggccg cgactctaga     1980

tcataatcag ccataccaca tttgtagagg ttttacttgc tttaaaaaac ctcccacacc     2040

tccccctgaa cctgaaacat aaaatgaatg caattgttgt tgttaacttg tttattgcag     2100

cttataatgg ttacaaataa agcaatagca tcacaaattt cacaaataaa gcattttttt     2160

cactgcattc tagttgtggt ttgtccaaac tcatcaatgt atcttaaggc gtaaattgta     2220

agcgttaata ttttgttaaa attcgcgtta aatttttgtt aaatcagctc attttttaac     2280

caataggccg aaatcggcaa aatcccttat aaatcaaaag aatagaccga gatagggttg     2340

agtgttgttc cagtttggaa caagagtcca ctattaaaga acgtggactc caacgtcaaa     2400

gggcgaaaaa ccgtctatca gggcgatggc ccactacgtg aaccatcacc ctaatcaagt     2460

tttttggggt cgaggtgccg taaagcacta aatcggaacc ctaaagggag cccccgattt     2520

agagcttgac ggggaaagcc ggcgaacgtg gcgagaaagg aagggaagaa agcgaaagga     2580

gcgggcgcta gggcgctggc aagtgtagcg gtcacgctgc gcgtaaccac cacacccgcc     2640

gcgcttaatg cgccgctaca gggcgcgtca ggtggcactt ttcggggaaa tgtgcgcgga     2700

acccctattt gtttattttt ctaaatacat tcaaatatgt atccgctcat gagacaataa     2760

ccctgataaa tgcttcaata atattgaaaa aggaagagtc ctgaggcgga aagaaccagc     2820

tgtggaatgt gtgtcagtta gggtgtggaa agtccccagg ctccccagca ggcagaagta     2880

tgcaaagcat gcatctcaat tagtcagcaa ccaggtgtgg aaagtcccca ggctccccag     2940

caggcagaag tatgcaaagc atgcatctca attagtcagc aaccatagtc ccgcccctaa     3000

ctccgcccat cccgccccta actccgccca gttccgccca ttctccgccc catggctgac     3060

taattttttt tatttatgca gaggccgagg ccgcctcggc ctctgagcta ttccagaagt     3120

agtgaggagg cttttttgga ggcctaggct tttgcaaaga tcgatcaaga gacaggatga     3180

ggatcgtttc gcatgattga acaagatgga ttgcacgcag gttctccggc cgcttgggtg     3240

gagaggctat tcggctatga ctgggcacaa cagacaatcg gctgctctga tgccgccgtg     3300

ttccggctgt cagcgcaggg gcgcccggtt ctttttgtca agaccgacct gtccggtgcc     3360

ctgaatgaac tgcaagacga ggcagcgcgg ctatcgtggc tggccacgac gggcgttcct     3420

tgcgcagctg tgctcgacgt tgtcactgaa gcgggaaggg actggctgct attgggcgaa     3480

gtgccggggc aggatctcct gtcatctcac cttgctcctg ccgagaaagt atccatcatg     3540

gctgatgcaa tgcggcggct gcatacgctt gatccggcta cctgcccatt cgaccaccaa     3600

gcgaaacatc gcatcgagcg agcacgtact cggatggaag ccggtcttgt cgatcaggat     3660

gatctggacg aagagcatca ggggctcgcg ccagccgaac tgttcgccag gctcaaggcg     3720

agcatgcccg acggcgagga tctcgtcgtg acccatggcg atgcctgctt gccgaatatc     3780

atggtggaaa atggccgctt ttctggattc atcgactgtg gccggctggg tgtggcggac     3840

cgctatcagg acatagcgtt ggctacccgt gatattgctg aagagcttgg cggcgaatgg     3900

gctgaccgct tcctcgtgct ttacggtatc gccgctcccg attcgcagcg catcgccttc     3960

tatcgccttc ttgacgagtt cttctgagcg ggactctggg gttcgaaatg accgaccaag     4020

cgacgcccaa cctgccatca cgagatttcg attccaccgc cgccttctat gaaaggttgg     4080

gcttcggaat cgttttccgg gacgccggct ggatgatcct ccagcgcggg gatctcatgc     4140

tggagttctt cgcccaccct agggggaggc taactgaaac acggaaggag acaataccgg     4200

aaggaacccg cgctatgacg gcaataaaaa gacagaataa aacgcacggt gttgggtcgt     4260

ttgttcataa acgcggggtt cggtcccagg gctggcactc tgtcgatacc ccaccgagac     4320

cccattgggg ccaatacgcc cgcgtttctt ccttttcccc accccacccc ccaagttcgg     4380

gtgaaggccc agggctcgca gccaacgtcg gggcggcagg ccctgccata gcctcaggtt     4440

actcatatat actttagatt gatttaaaac ttcattttta atttaaaagg atctaggtga     4500

agatcctttt tgataatctc atgaccaaaa tcccttaacg tgagttttcg ttccactgag     4560

cgtcagaccc cgtagaaaag atcaaaggat cttcttgaga tccttttttt ctgcgcgtaa     4620

tctgctgctt gcaaacaaaa aaaccaccgc taccagcggt ggtttgtttg ccggatcaag     4680

agctaccaac tctttttccg aaggtaactg gcttcagcag agcgcagata ccaaatactg     4740

tccttctagt gtagccgtag ttaggccacc acttcaagaa ctctgtagca ccgcctacat     4800

acctcgctct gctaatcctg ttaccagtgg ctgctgccag tggcgataag tcgtgtctta     4860

ccgggttgga ctcaagacga tagttaccgg ataaggcgca gcggtcgggc tgaacggggg     4920

gttcgtgcac acagcccagc ttggagcgaa cgacctacac cgaactgaga tacctacagc     4980

gtgagctatg agaaagcgcc acgcttcccg aagggagaaa ggcggacagg tatccggtaa     5040

gcggcagggt cggaacagga gagcgcacga gggagcttcc agggggaaac gcctggtatc     5100

tttatagtcc tgtcgggttt cgccacctct gacttgagcg tcgatttttg tgatgctcgt     5160

caggggggcg gagcctatgg aaaaacgcca gcaacgcggc ctttttacgg ttcctggcct     5220

tttgctggcc ttttgctcac atgttctttc ctgcgttatc ccctgattct gtggataacc     5280

gtattaccgc catgcat                                                    5297


<210>  14
<211>  4569
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  14
gccacacgct gggacttcgg agacggctcc gccgaggtgg atgccgctgg gccggctgcc       60

tcgcatcgct atgtgctgcc tgggcgctat cacgtgacgg ccgtgctggc cctgggggcc      120

ggctcagccc tgctggggac agacgtgcag gtggaagcgg cacctgccgc cctggagctc      180

gtgtgcccgt cctcggtgca gagtgacgag agccttgacc tcagcatcca gaaccgcggt      240

ggttcaggcc tggaggccgc ctacagcatc gtggccctgg gcgaggagcc ggcccgagcg      300

gtgcacccgc tctgcccctc ggacacggag atcttccctg gcaacgggca ctgctaccgc      360

ctggtggtgg agaaggcggc ctggctgcag gcgcaggagc agtgtcaggc ctgggccggg      420

gccgccctgg caatggtgga cagtcccgcc gtgcagcgct tcctggtctc ccgggtcacc      480

aggagcctag acgtgtggat cggcttctcg actgtgcagg gggtggaggt gggcccagcg      540

ccgcagggcg aggccttcag cctggagagc tgccagaact ggctgcccgg ggagccacac      600

ccagccacag ccgagcactg cgtccggctc gggcccaccg ggtggtgtaa caccgacctg      660

tgctcagcgc cgcacagcta cgtctgcgag ctgcagcccg gaggcccagt gcaggatgcc      720

gagaacctcc tcgtgggagc gcccagtggg gacctgcagg gacccctgac gcctctggca      780

cagcaggacg gcctctcagc cccgcacgag cccgtggagg tcatggtatt cccgggcctg      840

cgtctgagcc gtgaagcctt cctcaccacg gccgaatttg ggacccagga gctccggcgg      900

cccgcccagc tgcggctgca ggtgtaccgg ctcctcagca cagcagggac cccggagaac      960

ggcagcgagc ctgagagcag gtccccggac aacaggaccc agctggcccc cgcgtgcatg     1020

ccagggggac gctggtgccc tggagccaac atctgcttgc cgctggacgc ctcctgccac     1080

ccccaggcct gcgccaatgg ctgcacgtca gggccagggc tacccggggc cccctatgcg     1140

ctatggagag agttcctctt ctccgttccc gcggggcccc ccgcgcagta ctcggtcacc     1200

ctccacggcc aggatgtcct catgctccct ggtgacctcg ttggcttgca gcacgacgct     1260

ggccctggcg ccctcctgca ctgctcgccg gctcccggcc accctggtcc ccaggccccg     1320

tacctctccg ccaacgcctc gtcatggctg ccccacttgc cagcccagct ggagggcact     1380

tgggcctgcc ctgcctgtgc cctgcggctg cttgcagcca cggaacagct caccgtgctg     1440

ctgggcttga ggcccaaccc tggactgcgg ctgcctgggc gctatgaggt ccgggcagag     1500

gtgggcaatg gcgtgtccag gcacaacctc tcctgcagct ttgacgtggt ctccccagtg     1560

gctgggctgc gggtcatcta ccctgccccc cgcgacggcc gcctctacgt gcccaccaac     1620

ggctcagcct tggtgctcca ggtggactct ggtgccaacg ccacggccac ggctcgctgg     1680

cctgggggca gtgtcagcgc ccgctttgag aatgtctgcc ctgccctggt ggccaccttc     1740

gtgcccggct gcccctggga gaccaacgat accctgttct cagtggtagc actgccgtgg     1800

ctcagtgagg gggagcacgt ggtggacgtg gtggtggaaa acagcgccag ccgggccaac     1860

ctcagcctgc gggtgacggc ggaggagccc atctgtggcc tccgcgccac gcccagcccc     1920

gaggcccgtg tactgcaggg agtcctagtg aggtacagcc ccgtggtgga ggccggctcg     1980

gacatggtct tccggtggac catcaacgac aagcagtccc tgaccttcca gaacgtggtc     2040

ttcaatgtca tttatcagag cgcggcggtc ttcaagctct cactgacggc ctccaaccac     2100

gtgagcaacg tcaccgtgaa ctacaacgta accgtggagc ggatgaacag gatgcagggt     2160

ctgcaggtct ccacagtgcc ggccgtgctg tcccccaatg ccacgctagc actgacggcg     2220

ggcgtgctgg tggactcggc cgtggaggtg gccttcctgt ggacctttgg ggatggggag     2280

caggccctcc accagttcca gcctccgtac aacgagtcct tcccggttcc agacccctcg     2340

gtggcccagg tgctggtgga gcacaatgtc atgcacacct acgctgcccc aggtgagtac     2400

ctcctgaccg tgctggcatc taatgccttc gagaacctga cgcagcaggt gcctgtgagc     2460

gtgcgcgcct ccctgccctc cgtggctgtg ggtgtgagtg acggcgtcct ggtggccggc     2520

cggcccgtca ccttctaccc gcacccgctg ccctcgcctg ggggtgttct ttacacgtgg     2580

gacttcgggg acggctcccc tgtcctgacc cagagccagc cggctgccaa ccacacctat     2640

gcctcgaggg gcacctacca cgtgcgcctg gaggtcaaca acacggtgag cggtgcggcg     2700

gcccaggcgg atgtgcgcgt ctttgaggag ctccgcggac tcagcgtgga catgagcctg     2760

gccgtggagc agggcgcccc cgtggtggtc agcgccgcgg tgcagacggg cgacaacatc     2820

acgtggacct tcgacatggg ggacggcacc gtgctgtcgg gcccggaggc aacagtggag     2880

catgtgtacc tgcgggcaca gaactgcaca gtgaccgtgg gtgcggccag ccccgccggc     2940

cacctggccc ggagcctgca cgtgctggtc ttcgtcctgg aggtgctgcg cgttgaaccc     3000

gccgcctgca tccccacgca gcctgacgcg cggctcacgg cctacgtcac cgggaacccg     3060

gcccactacc tcttcgactg gaccttcggg gatggctcct ccaacacgac cgtgcggggg     3120

tgcccgacgg tgacacacaa cttcacgcgg agcggcacgt tccccctggc gctggtgctg     3180

tccagccgcg tgaacagggc gcattacttc accagcatct gcgtggagcc agaggtgggc     3240

aacgtcaccc tgcagccaga gaggcagttt gtgcagctcg gggacgaggc ctggctggtg     3300

gcatgtgcct ggcccccgtt cccctaccgc tacacctggg actttggcac cgaggaagcc     3360

gcccccaccc gtgccagggg ccctgaggtg acgttcatct accgagaccc aggctcctat     3420

cttgtgacag tcaccgcgtc caacaacatc tctgctgcca atgactcagc cctggtggag     3480

gtgcaggagc ccgtgctggt caccagcatc aaggtcaatg gctcccttgg gctggagctg     3540

cagcagccgt acctgttctc tgctgtgggc cgtgggcgcc ccgccagcta cctgtgggat     3600

ctgggggacg gtgggtggct cgagggtccg gaggtcaccc acgcttacaa cagcacaggt     3660

gacttcaccg ttagggtggc cggctggaat gaggtgagcc gcagcgaggc ctggctcaat     3720

gtgacggtga agcggcgcgt gcgggggctc gtcgtcaatg caagccgcac ggtggtgccc     3780

ctgaatggga gcgtgagctt cagcacgtcg ctggaggccg gcagtgatgt gcgctattcc     3840

tgggtgctct gtgaccgctg cacgcccatc cctgggggtc ctaccatctc ttacaccttc     3900

cgctccgtgg gcaccttcaa tatcatcgtc acggctgaga acgaggtggg ctccgcccag     3960

gacagcatct tcgtctatgt cctgcagctc atagaggggc tgcaggtggt gggcggtggc     4020

cgctacttcc ccaccaacca cacggtacag ctgcaggccg tggttaggga tggcaccaac     4080

gtctcctaca gctggactgc ctggagggac aggggcccgg ccctggccgg cagcggcaaa     4140

ggcttctcgc tcaccgtgct cgaggccggc acctaccatg tgcagctgcg ggccaccaac     4200

atgctgggca gcgcctgggc cgactgcacc atggacttcg tggagcctgt ggggtggctg     4260

atggtggccg cctccccgaa cccagctgcc gtcaacacaa gcgtcaccct cagtgccgag     4320

ctggctggtg gcagtggtgt cgtatacact tggtccttgg aggaggggct gagctgggag     4380

acctccgagc catttaccac ccatagcttc cccacacccg gcctgcactt ggtcaccatg     4440

acggcaggga acccgctggg ctcagccaac gccaccgtgg aagtggatgt gcaggtgcct     4500

gtgagtggcc tcagcatcag ggccagcgag cccggacacc atcaccatca ccatcaccat     4560

caccattag                                                             4569


<210>  15
<211>  1522
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  15

Ala Thr Arg Trp Asp Phe Gly Asp Gly Ser Ala Glu Val Asp Ala Ala 
1               5                   10                  15      


Gly Pro Ala Ala Ser His Arg Tyr Val Leu Pro Gly Arg Tyr His Val 
            20                  25                  30          


Thr Ala Val Leu Ala Leu Gly Ala Gly Ser Ala Leu Leu Gly Thr Asp 
        35                  40                  45              


Val Gln Val Glu Ala Ala Pro Ala Ala Leu Glu Leu Val Cys Pro Ser 
    50                  55                  60                  


Ser Val Gln Ser Asp Glu Ser Leu Asp Leu Ser Ile Gln Asn Arg Gly 
65                  70                  75                  80  


Gly Ser Gly Leu Glu Ala Ala Tyr Ser Ile Val Ala Leu Gly Glu Glu 
                85                  90                  95      


Pro Ala Arg Ala Val His Pro Leu Cys Pro Ser Asp Thr Glu Ile Phe 
            100                 105                 110         


Pro Gly Asn Gly His Cys Tyr Arg Leu Val Val Glu Lys Ala Ala Trp 
        115                 120                 125             


Leu Gln Ala Gln Glu Gln Cys Gln Ala Trp Ala Gly Ala Ala Leu Ala 
    130                 135                 140                 


Met Val Asp Ser Pro Ala Val Gln Arg Phe Leu Val Ser Arg Val Thr 
145                 150                 155                 160 


Arg Ser Leu Asp Val Trp Ile Gly Phe Ser Thr Val Gln Gly Val Glu 
                165                 170                 175     


Val Gly Pro Ala Pro Gln Gly Glu Ala Phe Ser Leu Glu Ser Cys Gln 
            180                 185                 190         


Asn Trp Leu Pro Gly Glu Pro His Pro Ala Thr Ala Glu His Cys Val 
        195                 200                 205             


Arg Leu Gly Pro Thr Gly Trp Cys Asn Thr Asp Leu Cys Ser Ala Pro 
    210                 215                 220                 


His Ser Tyr Val Cys Glu Leu Gln Pro Gly Gly Pro Val Gln Asp Ala 
225                 230                 235                 240 


Glu Asn Leu Leu Val Gly Ala Pro Ser Gly Asp Leu Gln Gly Pro Leu 
                245                 250                 255     


Thr Pro Leu Ala Gln Gln Asp Gly Leu Ser Ala Pro His Glu Pro Val 
            260                 265                 270         


Glu Val Met Val Phe Pro Gly Leu Arg Leu Ser Arg Glu Ala Phe Leu 
        275                 280                 285             


Thr Thr Ala Glu Phe Gly Thr Gln Glu Leu Arg Arg Pro Ala Gln Leu 
    290                 295                 300                 


Arg Leu Gln Val Tyr Arg Leu Leu Ser Thr Ala Gly Thr Pro Glu Asn 
305                 310                 315                 320 


Gly Ser Glu Pro Glu Ser Arg Ser Pro Asp Asn Arg Thr Gln Leu Ala 
                325                 330                 335     


Pro Ala Cys Met Pro Gly Gly Arg Trp Cys Pro Gly Ala Asn Ile Cys 
            340                 345                 350         


Leu Pro Leu Asp Ala Ser Cys His Pro Gln Ala Cys Ala Asn Gly Cys 
        355                 360                 365             


Thr Ser Gly Pro Gly Leu Pro Gly Ala Pro Tyr Ala Leu Trp Arg Glu 
    370                 375                 380                 


Phe Leu Phe Ser Val Pro Ala Gly Pro Pro Ala Gln Tyr Ser Val Thr 
385                 390                 395                 400 


Leu His Gly Gln Asp Val Leu Met Leu Pro Gly Asp Leu Val Gly Leu 
                405                 410                 415     


Gln His Asp Ala Gly Pro Gly Ala Leu Leu His Cys Ser Pro Ala Pro 
            420                 425                 430         


Gly His Pro Gly Pro Gln Ala Pro Tyr Leu Ser Ala Asn Ala Ser Ser 
        435                 440                 445             


Trp Leu Pro His Leu Pro Ala Gln Leu Glu Gly Thr Trp Ala Cys Pro 
    450                 455                 460                 


Ala Cys Ala Leu Arg Leu Leu Ala Ala Thr Glu Gln Leu Thr Val Leu 
465                 470                 475                 480 


Leu Gly Leu Arg Pro Asn Pro Gly Leu Arg Leu Pro Gly Arg Tyr Glu 
                485                 490                 495     


Val Arg Ala Glu Val Gly Asn Gly Val Ser Arg His Asn Leu Ser Cys 
            500                 505                 510         


Ser Phe Asp Val Val Ser Pro Val Ala Gly Leu Arg Val Ile Tyr Pro 
        515                 520                 525             


Ala Pro Arg Asp Gly Arg Leu Tyr Val Pro Thr Asn Gly Ser Ala Leu 
    530                 535                 540                 


Val Leu Gln Val Asp Ser Gly Ala Asn Ala Thr Ala Thr Ala Arg Trp 
545                 550                 555                 560 


Pro Gly Gly Ser Val Ser Ala Arg Phe Glu Asn Val Cys Pro Ala Leu 
                565                 570                 575     


Val Ala Thr Phe Val Pro Gly Cys Pro Trp Glu Thr Asn Asp Thr Leu 
            580                 585                 590         


Phe Ser Val Val Ala Leu Pro Trp Leu Ser Glu Gly Glu His Val Val 
        595                 600                 605             


Asp Val Val Val Glu Asn Ser Ala Ser Arg Ala Asn Leu Ser Leu Arg 
    610                 615                 620                 


Val Thr Ala Glu Glu Pro Ile Cys Gly Leu Arg Ala Thr Pro Ser Pro 
625                 630                 635                 640 


Glu Ala Arg Val Leu Gln Gly Val Leu Val Arg Tyr Ser Pro Val Val 
                645                 650                 655     


Glu Ala Gly Ser Asp Met Val Phe Arg Trp Thr Ile Asn Asp Lys Gln 
            660                 665                 670         


Ser Leu Thr Phe Gln Asn Val Val Phe Asn Val Ile Tyr Gln Ser Ala 
        675                 680                 685             


Ala Val Phe Lys Leu Ser Leu Thr Ala Ser Asn His Val Ser Asn Val 
    690                 695                 700                 


Thr Val Asn Tyr Asn Val Thr Val Glu Arg Met Asn Arg Met Gln Gly 
705                 710                 715                 720 


Leu Gln Val Ser Thr Val Pro Ala Val Leu Ser Pro Asn Ala Thr Leu 
                725                 730                 735     


Ala Leu Thr Ala Gly Val Leu Val Asp Ser Ala Val Glu Val Ala Phe 
            740                 745                 750         


Leu Trp Thr Phe Gly Asp Gly Glu Gln Ala Leu His Gln Phe Gln Pro 
        755                 760                 765             


Pro Tyr Asn Glu Ser Phe Pro Val Pro Asp Pro Ser Val Ala Gln Val 
    770                 775                 780                 


Leu Val Glu His Asn Val Met His Thr Tyr Ala Ala Pro Gly Glu Tyr 
785                 790                 795                 800 


Leu Leu Thr Val Leu Ala Ser Asn Ala Phe Glu Asn Leu Thr Gln Gln 
                805                 810                 815     


Val Pro Val Ser Val Arg Ala Ser Leu Pro Ser Val Ala Val Gly Val 
            820                 825                 830         


Ser Asp Gly Val Leu Val Ala Gly Arg Pro Val Thr Phe Tyr Pro His 
        835                 840                 845             


Pro Leu Pro Ser Pro Gly Gly Val Leu Tyr Thr Trp Asp Phe Gly Asp 
    850                 855                 860                 


Gly Ser Pro Val Leu Thr Gln Ser Gln Pro Ala Ala Asn His Thr Tyr 
865                 870                 875                 880 


Ala Ser Arg Gly Thr Tyr His Val Arg Leu Glu Val Asn Asn Thr Val 
                885                 890                 895     


Ser Gly Ala Ala Ala Gln Ala Asp Val Arg Val Phe Glu Glu Leu Arg 
            900                 905                 910         


Gly Leu Ser Val Asp Met Ser Leu Ala Val Glu Gln Gly Ala Pro Val 
        915                 920                 925             


Val Val Ser Ala Ala Val Gln Thr Gly Asp Asn Ile Thr Trp Thr Phe 
    930                 935                 940                 


Asp Met Gly Asp Gly Thr Val Leu Ser Gly Pro Glu Ala Thr Val Glu 
945                 950                 955                 960 


His Val Tyr Leu Arg Ala Gln Asn Cys Thr Val Thr Val Gly Ala Ala 
                965                 970                 975     


Ser Pro Ala Gly His Leu Ala Arg Ser Leu His Val Leu Val Phe Val 
            980                 985                 990         


Leu Glu Val Leu Arg Val Glu Pro  Ala Ala Cys Ile Pro  Thr Gln Pro 
        995                 1000                 1005             


Asp Ala  Arg Leu Thr Ala Tyr  Val Thr Gly Asn Pro  Ala His Tyr 
    1010                 1015                 1020             


Leu Phe  Asp Trp Thr Phe Gly  Asp Gly Ser Ser Asn  Thr Thr Val 
    1025                 1030                 1035             


Arg Gly  Cys Pro Thr Val Thr  His Asn Phe Thr Arg  Ser Gly Thr 
    1040                 1045                 1050             


Phe Pro  Leu Ala Leu Val Leu  Ser Ser Arg Val Asn  Arg Ala His 
    1055                 1060                 1065             


Tyr Phe  Thr Ser Ile Cys Val  Glu Pro Glu Val Gly  Asn Val Thr 
    1070                 1075                 1080             


Leu Gln  Pro Glu Arg Gln Phe  Val Gln Leu Gly Asp  Glu Ala Trp 
    1085                 1090                 1095             


Leu Val  Ala Cys Ala Trp Pro  Pro Phe Pro Tyr Arg  Tyr Thr Trp 
    1100                 1105                 1110             


Asp Phe  Gly Thr Glu Glu Ala  Ala Pro Thr Arg Ala  Arg Gly Pro 
    1115                 1120                 1125             


Glu Val  Thr Phe Ile Tyr Arg  Asp Pro Gly Ser Tyr  Leu Val Thr 
    1130                 1135                 1140             


Val Thr  Ala Ser Asn Asn Ile  Ser Ala Ala Asn Asp  Ser Ala Leu 
    1145                 1150                 1155             


Val Glu  Val Gln Glu Pro Val  Leu Val Thr Ser Ile  Lys Val Asn 
    1160                 1165                 1170             


Gly Ser  Leu Gly Leu Glu Leu  Gln Gln Pro Tyr Leu  Phe Ser Ala 
    1175                 1180                 1185             


Val Gly  Arg Gly Arg Pro Ala  Ser Tyr Leu Trp Asp  Leu Gly Asp 
    1190                 1195                 1200             


Gly Gly  Trp Leu Glu Gly Pro  Glu Val Thr His Ala  Tyr Asn Ser 
    1205                 1210                 1215             


Thr Gly  Asp Phe Thr Val Arg  Val Ala Gly Trp Asn  Glu Val Ser 
    1220                 1225                 1230             


Arg Ser  Glu Ala Trp Leu Asn  Val Thr Val Lys Arg  Arg Val Arg 
    1235                 1240                 1245             


Gly Leu  Val Val Asn Ala Ser  Arg Thr Val Val Pro  Leu Asn Gly 
    1250                 1255                 1260             


Ser Val  Ser Phe Ser Thr Ser  Leu Glu Ala Gly Ser  Asp Val Arg 
    1265                 1270                 1275             


Tyr Ser  Trp Val Leu Cys Asp  Arg Cys Thr Pro Ile  Pro Gly Gly 
    1280                 1285                 1290             


Pro Thr  Ile Ser Tyr Thr Phe  Arg Ser Val Gly Thr  Phe Asn Ile 
    1295                 1300                 1305             


Ile Val  Thr Ala Glu Asn Glu  Val Gly Ser Ala Gln  Asp Ser Ile 
    1310                 1315                 1320             


Phe Val  Tyr Val Leu Gln Leu  Ile Glu Gly Leu Gln  Val Val Gly 
    1325                 1330                 1335             


Gly Gly  Arg Tyr Phe Pro Thr  Asn His Thr Val Gln  Leu Gln Ala 
    1340                 1345                 1350             


Val Val  Arg Asp Gly Thr Asn  Val Ser Tyr Ser Trp  Thr Ala Trp 
    1355                 1360                 1365             


Arg Asp  Arg Gly Pro Ala Leu  Ala Gly Ser Gly Lys  Gly Phe Ser 
    1370                 1375                 1380             


Leu Thr  Val Leu Glu Ala Gly  Thr Tyr His Val Gln  Leu Arg Ala 
    1385                 1390                 1395             


Thr Asn  Met Leu Gly Ser Ala  Trp Ala Asp Cys Thr  Met Asp Phe 
    1400                 1405                 1410             


Val Glu  Pro Val Gly Trp Leu  Met Val Ala Ala Ser  Pro Asn Pro 
    1415                 1420                 1425             


Ala Ala  Val Asn Thr Ser Val  Thr Leu Ser Ala Glu  Leu Ala Gly 
    1430                 1435                 1440             


Gly Ser  Gly Val Val Tyr Thr  Trp Ser Leu Glu Glu  Gly Leu Ser 
    1445                 1450                 1455             


Trp Glu  Thr Ser Glu Pro Phe  Thr Thr His Ser Phe  Pro Thr Pro 
    1460                 1465                 1470             


Gly Leu  His Leu Val Thr Met  Thr Ala Gly Asn Pro  Leu Gly Ser 
    1475                 1480                 1485             


Ala Asn  Ala Thr Val Glu Val  Asp Val Gln Val Pro  Val Ser Gly 
    1490                 1495                 1500             


Leu Ser  Ile Arg Ala Ser Glu  Pro Gly His His His  His His His 
    1505                 1510                 1515             


His His  His His 
    1520         


<210>  16
<211>  2358
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  16
aaccgctcgg cgcagtttga ggccgccacc agccccagcc cccggcgtgt ggcctaccac       60

tgggactttg gggatgggtc gccagggcag gacacagatg agcccagggc cgagcactcc      120

tacctgaggc ctggggacta ccgcgtgcag gtgaacgcct ccaacctggt gagcttcttc      180

gtggcgcagg ccacggtgac cgtccaggtg ctggcctgcc gggagccgga ggtggacgtg      240

gtcctgcccc tgcaggtgct gatgcggcga tcacagcgca actacttgga ggcccacgtt      300

gacctgcgcg actgcgtcac ctaccagact gagtaccgct gggaggtgta tcgcaccgcc      360

agctgccagc ggccggggcg cccagcgcgt gtggccctgc ccggcgtgga cgtgagccgg      420

cctcggctgg tgctgccgcg gctggcgctg cctgtggggc actactgctt tgtgtttgtc      480

gtgtcatttg gggacacgcc actgacacag agcatccagg ccaatgtgac ggtggccccc      540

gagcgcctgg tgcccatcat tgagggtggc tcataccgcg tgtggtcaga cacacgggac      600

ctggtgctgg atgggagcga gtcctacgac cccaacctgg aggacggcga ccagacgccg      660

ctcagtttcc actgggcctg tgtggcttcg acacagaggg aggctggcgg gtgtgcgctg      720

aactttgggc cccgcgggag cagcacggtc accattccac gggagcggct ggcggctggc      780

gtggagtaca ccttcagcct gaccgtgtgg aaggccggcc gcaaggagga ggccaccaac      840

cagacggtgc tgatccggag tggccgggtg cccattgtgt ccttggagtg tgtgtcctgc      900

aaggcacagg ccgtgtacga agtgagccgc agctcctacg tgtacttgga gggccgctgc      960

ctcaattgca gcagcggctc caagcgaggg cggtgggctg cacgtacgtt cagcaacaag     1020

acgctggtgc tggatgagac caccacatcc acgggcagtg caggcatgcg actggtgctg     1080

cggcggggcg tgctgcggga cggcgaggga tacaccttca cgctcacggt gctgggccgc     1140

tctggcgagg aggagggctg cgcctccatc cgcctgtccc ccaaccgccc gccgctgggg     1200

ggctcttgcc gcctcttccc actgggcgct gtgcacgccc tcaccaccaa ggtgcacttc     1260

gaatgcacgg gctggcatga cgcggaggat gctggcgccc cgctggtgta cgccctgctg     1320

ctgcggcgct gtcgccaggg ccactgcgag gagttctgtg tctacaaggg cagcctctcc     1380

agctacggag ccgtgctgcc cccgggtttc aggccacact tcgaggtggg cctggccgtg     1440

gtggtgcagg accagctggg agccgctgtg gtcgccctca acaggtcttt ggccatcacc     1500

ctcccagagc ccaacggcag cgcaacgggg ctcacagtct ggctgcacgg gctcaccgct     1560

agtgtgctcc cagggctgct gcggcaggcc gatccccagc acgtcatcga gtactcgttg     1620

gccctggtca ccgtgctgaa cgagtacgag cgggccctgg acgtggcggc agagcccaag     1680

cacgagcggc agcaccgagc ccagatacgc aagaacatca cggagactct ggtgtccctg     1740

agggtccaca ctgtggatga catccagcag atcgctgctg cgctggccca gtgcatgggg     1800

cccagcaggg agctcgtatg ccgctcgtgc ctgaagcaga cgctgcacaa gctggaggcc     1860

atgatgctca tcctgcaggc agagaccacc gcgggcaccg tgacgcccac cgccatcgga     1920

gacagcatcc tcaacatcac aggagacctc atccacctgg ccagctcgga cgtgcgggca     1980

ccacagccct cagagctggg agccgagtca ccatctcgga tggtggcgtc ccaggcctac     2040

aacctgacct ctgccctcat gcgcatcctc atgcgctccc gcgtgctcaa cgaggagccc     2100

ctgacgctgg cgggcgagga gatcgtggcc cagggcaagc gctcggaccc gcggagcctg     2160

ctgtgctatg gcggcgcccc agggcctggc tgccacttct ccatccccga ggctttcagc     2220

ggggccctgg ccaacctcag tgacgtggtg cagctcatct ttctggtgga ctccaatccc     2280

tttccctttg gctatatcag caactacacc gtctccacca aggtgcacca tcaccatcac     2340

catcaccatc accattag                                                   2358


<210>  17
<211>  785
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  17

Asn Arg Ser Ala Gln Phe Glu Ala Ala Thr Ser Pro Ser Pro Arg Arg 
1               5                   10                  15      


Val Ala Tyr His Trp Asp Phe Gly Asp Gly Ser Pro Gly Gln Asp Thr 
            20                  25                  30          


Asp Glu Pro Arg Ala Glu His Ser Tyr Leu Arg Pro Gly Asp Tyr Arg 
        35                  40                  45              


Val Gln Val Asn Ala Ser Asn Leu Val Ser Phe Phe Val Ala Gln Ala 
    50                  55                  60                  


Thr Val Thr Val Gln Val Leu Ala Cys Arg Glu Pro Glu Val Asp Val 
65                  70                  75                  80  


Val Leu Pro Leu Gln Val Leu Met Arg Arg Ser Gln Arg Asn Tyr Leu 
                85                  90                  95      


Glu Ala His Val Asp Leu Arg Asp Cys Val Thr Tyr Gln Thr Glu Tyr 
            100                 105                 110         


Arg Trp Glu Val Tyr Arg Thr Ala Ser Cys Gln Arg Pro Gly Arg Pro 
        115                 120                 125             


Ala Arg Val Ala Leu Pro Gly Val Asp Val Ser Arg Pro Arg Leu Val 
    130                 135                 140                 


Leu Pro Arg Leu Ala Leu Pro Val Gly His Tyr Cys Phe Val Phe Val 
145                 150                 155                 160 


Val Ser Phe Gly Asp Thr Pro Leu Thr Gln Ser Ile Gln Ala Asn Val 
                165                 170                 175     


Thr Val Ala Pro Glu Arg Leu Val Pro Ile Ile Glu Gly Gly Ser Tyr 
            180                 185                 190         


Arg Val Trp Ser Asp Thr Arg Asp Leu Val Leu Asp Gly Ser Glu Ser 
        195                 200                 205             


Tyr Asp Pro Asn Leu Glu Asp Gly Asp Gln Thr Pro Leu Ser Phe His 
    210                 215                 220                 


Trp Ala Cys Val Ala Ser Thr Gln Arg Glu Ala Gly Gly Cys Ala Leu 
225                 230                 235                 240 


Asn Phe Gly Pro Arg Gly Ser Ser Thr Val Thr Ile Pro Arg Glu Arg 
                245                 250                 255     


Leu Ala Ala Gly Val Glu Tyr Thr Phe Ser Leu Thr Val Trp Lys Ala 
            260                 265                 270         


Gly Arg Lys Glu Glu Ala Thr Asn Gln Thr Val Leu Ile Arg Ser Gly 
        275                 280                 285             


Arg Val Pro Ile Val Ser Leu Glu Cys Val Ser Cys Lys Ala Gln Ala 
    290                 295                 300                 


Val Tyr Glu Val Ser Arg Ser Ser Tyr Val Tyr Leu Glu Gly Arg Cys 
305                 310                 315                 320 


Leu Asn Cys Ser Ser Gly Ser Lys Arg Gly Arg Trp Ala Ala Arg Thr 
                325                 330                 335     


Phe Ser Asn Lys Thr Leu Val Leu Asp Glu Thr Thr Thr Ser Thr Gly 
            340                 345                 350         


Ser Ala Gly Met Arg Leu Val Leu Arg Arg Gly Val Leu Arg Asp Gly 
        355                 360                 365             


Glu Gly Tyr Thr Phe Thr Leu Thr Val Leu Gly Arg Ser Gly Glu Glu 
    370                 375                 380                 


Glu Gly Cys Ala Ser Ile Arg Leu Ser Pro Asn Arg Pro Pro Leu Gly 
385                 390                 395                 400 


Gly Ser Cys Arg Leu Phe Pro Leu Gly Ala Val His Ala Leu Thr Thr 
                405                 410                 415     


Lys Val His Phe Glu Cys Thr Gly Trp His Asp Ala Glu Asp Ala Gly 
            420                 425                 430         


Ala Pro Leu Val Tyr Ala Leu Leu Leu Arg Arg Cys Arg Gln Gly His 
        435                 440                 445             


Cys Glu Glu Phe Cys Val Tyr Lys Gly Ser Leu Ser Ser Tyr Gly Ala 
    450                 455                 460                 


Val Leu Pro Pro Gly Phe Arg Pro His Phe Glu Val Gly Leu Ala Val 
465                 470                 475                 480 


Val Val Gln Asp Gln Leu Gly Ala Ala Val Val Ala Leu Asn Arg Ser 
                485                 490                 495     


Leu Ala Ile Thr Leu Pro Glu Pro Asn Gly Ser Ala Thr Gly Leu Thr 
            500                 505                 510         


Val Trp Leu His Gly Leu Thr Ala Ser Val Leu Pro Gly Leu Leu Arg 
        515                 520                 525             


Gln Ala Asp Pro Gln His Val Ile Glu Tyr Ser Leu Ala Leu Val Thr 
    530                 535                 540                 


Val Leu Asn Glu Tyr Glu Arg Ala Leu Asp Val Ala Ala Glu Pro Lys 
545                 550                 555                 560 


His Glu Arg Gln His Arg Ala Gln Ile Arg Lys Asn Ile Thr Glu Thr 
                565                 570                 575     


Leu Val Ser Leu Arg Val His Thr Val Asp Asp Ile Gln Gln Ile Ala 
            580                 585                 590         


Ala Ala Leu Ala Gln Cys Met Gly Pro Ser Arg Glu Leu Val Cys Arg 
        595                 600                 605             


Ser Cys Leu Lys Gln Thr Leu His Lys Leu Glu Ala Met Met Leu Ile 
    610                 615                 620                 


Leu Gln Ala Glu Thr Thr Ala Gly Thr Val Thr Pro Thr Ala Ile Gly 
625                 630                 635                 640 


Asp Ser Ile Leu Asn Ile Thr Gly Asp Leu Ile His Leu Ala Ser Ser 
                645                 650                 655     


Asp Val Arg Ala Pro Gln Pro Ser Glu Leu Gly Ala Glu Ser Pro Ser 
            660                 665                 670         


Arg Met Val Ala Ser Gln Ala Tyr Asn Leu Thr Ser Ala Leu Met Arg 
        675                 680                 685             


Ile Leu Met Arg Ser Arg Val Leu Asn Glu Glu Pro Leu Thr Leu Ala 
    690                 695                 700                 


Gly Glu Glu Ile Val Ala Gln Gly Lys Arg Ser Asp Pro Arg Ser Leu 
705                 710                 715                 720 


Leu Cys Tyr Gly Gly Ala Pro Gly Pro Gly Cys His Phe Ser Ile Pro 
                725                 730                 735     


Glu Ala Phe Ser Gly Ala Leu Ala Asn Leu Ser Asp Val Val Gln Leu 
            740                 745                 750         


Ile Phe Leu Val Asp Ser Asn Pro Phe Pro Phe Gly Tyr Ile Ser Asn 
        755                 760                 765             


Tyr Thr Val Ser Thr Lys Val His His His His His His His His His 
    770                 775                 780                 


His 
785 


<210>  18
<211>  1821
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  18
atggccgagg aggcagccca gaacatttct gatgaccagg aaaggtgtct ccaggctgcc       60

tgctgccttt cctttggtgg tgagctgtct gtgagcactg acaagagctg gggtcttcat      120

ctgtgcagct gtagccctcc tggaggtgga ttgtgggtcg aggtctatgc taatcatgtg      180

cttcttatga gtgatgggaa gtgtggctgt ccttggtgtg ctctgaatgg aaaggcagaa      240

gaccgggaat cacagagccc atcctcatca gcttccaggc agaagaacat ttggaaaaca      300

actagcgaag cagcgttaag tgttgttaat gaaaaaacac aggctgttgt taatgaaaaa      360

acacaggcgc ctctggattg tgataacagt gctgatagaa ttccccacaa acctttcatt      420

ataatcgcaa gggcctggag cagtggtggc cccaggttcc atcacaggcg gctgtgtgct      480

actgggaccg cagacagcac attctctgct cttctccagc tccagggcac cacttctgca      540

gcagctccct gcagcctgaa gatggaggct tcctgctgtg tcctgagact gctgtgctgt      600

gcggaggatg tggccacggg gctgcttcct gggactgtca cgatggagac ccccaccaag      660

gtggccagac ccactcagac cagctcccag cgagtgcccc tgtggccgat ttcacatttt      720

cccacttctc ccagaagctc ccacggcctt ccgcctggca ttcctcgcac ccccagcttc      780

acggcatcgc agtctggttc tgagatcctc tatcccccta ctcagcatcc tcctgtggcc      840

atcctagctc gaaattctga taacttcatg aaccctgttc ttaattgctc cctggaagtg      900

gaagctcggg cacctccaaa tctgggattc cgtgttcata tggcttctgg agaggctctc      960

tgtctgatga tggatttcgg ggacagttct ggggttgaaa tgaggctaca caacatgtct     1020

gaggcaatgg cggtgactgc ctaccaccag tactcaaaag gtattttttt tcatctttta     1080

cattttcagt tggatatgtc cacctacaaa gaagcagaga cacaaaatac aactttaaat     1140

gtttacttgt gccaaagtga aaacagctgc ctggaagact cagaccccag taaccttgga     1200

tatgagctta tttctgcctt tgtcaccaaa ggagtctata tgctcaaggc tgttatttat     1260

aacgagtttc atggaaccga agtggagctt gggccttatt atgtggagat tggccatgag     1320

gccgtgtctg cgttcatgaa ctccagcagt gtccatgaag atgaagtgct tgtctttgct     1380

gactcccaag tgaatcagaa aagcactgtg gttatacatc actttccatc tattccttca     1440

tataacgtgt cctttatttc tcagactcaa gtgggtgaca gccaggcttg gcacagcatg     1500

actgtctggt ataagatgca atccgtctct gtctacacaa atggaactgt gtttgccaca     1560

gacacagaca ttacatttac agctgttacc aaggaaacaa tacccctgga atttgagtgg     1620

tattttggag aggacccacc agtgaggaca acttcaagaa gcattaaaaa aagactcagc     1680

atcccccaat ggtatcgtgt gatggttaag gcttccaaca ggatgagcag tgtggtctct     1740

gagccccatg tcatcagggt gcagaagaaa attgtggcca atcggctcca ccatcaccat     1800

caccatcacc atcaccatta g                                               1821


<210>  19
<211>  606
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  19

Met Ala Glu Glu Ala Ala Gln Asn Ile Ser Asp Asp Gln Glu Arg Cys 
1               5                   10                  15      


Leu Gln Ala Ala Cys Cys Leu Ser Phe Gly Gly Glu Leu Ser Val Ser 
            20                  25                  30          


Thr Asp Lys Ser Trp Gly Leu His Leu Cys Ser Cys Ser Pro Pro Gly 
        35                  40                  45              


Gly Gly Leu Trp Val Glu Val Tyr Ala Asn His Val Leu Leu Met Ser 
    50                  55                  60                  


Asp Gly Lys Cys Gly Cys Pro Trp Cys Ala Leu Asn Gly Lys Ala Glu 
65                  70                  75                  80  


Asp Arg Glu Ser Gln Ser Pro Ser Ser Ser Ala Ser Arg Gln Lys Asn 
                85                  90                  95      


Ile Trp Lys Thr Thr Ser Glu Ala Ala Leu Ser Val Val Asn Glu Lys 
            100                 105                 110         


Thr Gln Ala Val Val Asn Glu Lys Thr Gln Ala Pro Leu Asp Cys Asp 
        115                 120                 125             


Asn Ser Ala Asp Arg Ile Pro His Lys Pro Phe Ile Ile Ile Ala Arg 
    130                 135                 140                 


Ala Trp Ser Ser Gly Gly Pro Arg Phe His His Arg Arg Leu Cys Ala 
145                 150                 155                 160 


Thr Gly Thr Ala Asp Ser Thr Phe Ser Ala Leu Leu Gln Leu Gln Gly 
                165                 170                 175     


Thr Thr Ser Ala Ala Ala Pro Cys Ser Leu Lys Met Glu Ala Ser Cys 
            180                 185                 190         


Cys Val Leu Arg Leu Leu Cys Cys Ala Glu Asp Val Ala Thr Gly Leu 
        195                 200                 205             


Leu Pro Gly Thr Val Thr Met Glu Thr Pro Thr Lys Val Ala Arg Pro 
    210                 215                 220                 


Thr Gln Thr Ser Ser Gln Arg Val Pro Leu Trp Pro Ile Ser His Phe 
225                 230                 235                 240 


Pro Thr Ser Pro Arg Ser Ser His Gly Leu Pro Pro Gly Ile Pro Arg 
                245                 250                 255     


Thr Pro Ser Phe Thr Ala Ser Gln Ser Gly Ser Glu Ile Leu Tyr Pro 
            260                 265                 270         


Pro Thr Gln His Pro Pro Val Ala Ile Leu Ala Arg Asn Ser Asp Asn 
        275                 280                 285             


Phe Met Asn Pro Val Leu Asn Cys Ser Leu Glu Val Glu Ala Arg Ala 
    290                 295                 300                 


Pro Pro Asn Leu Gly Phe Arg Val His Met Ala Ser Gly Glu Ala Leu 
305                 310                 315                 320 


Cys Leu Met Met Asp Phe Gly Asp Ser Ser Gly Val Glu Met Arg Leu 
                325                 330                 335     


His Asn Met Ser Glu Ala Met Ala Val Thr Ala Tyr His Gln Tyr Ser 
            340                 345                 350         


Lys Gly Ile Phe Phe His Leu Leu His Phe Gln Leu Asp Met Ser Thr 
        355                 360                 365             


Tyr Lys Glu Ala Glu Thr Gln Asn Thr Thr Leu Asn Val Tyr Leu Cys 
    370                 375                 380                 


Gln Ser Glu Asn Ser Cys Leu Glu Asp Ser Asp Pro Ser Asn Leu Gly 
385                 390                 395                 400 


Tyr Glu Leu Ile Ser Ala Phe Val Thr Lys Gly Val Tyr Met Leu Lys 
                405                 410                 415     


Ala Val Ile Tyr Asn Glu Phe His Gly Thr Glu Val Glu Leu Gly Pro 
            420                 425                 430         


Tyr Tyr Val Glu Ile Gly His Glu Ala Val Ser Ala Phe Met Asn Ser 
        435                 440                 445             


Ser Ser Val His Glu Asp Glu Val Leu Val Phe Ala Asp Ser Gln Val 
    450                 455                 460                 


Asn Gln Lys Ser Thr Val Val Ile His His Phe Pro Ser Ile Pro Ser 
465                 470                 475                 480 


Tyr Asn Val Ser Phe Ile Ser Gln Thr Gln Val Gly Asp Ser Gln Ala 
                485                 490                 495     


Trp His Ser Met Thr Val Trp Tyr Lys Met Gln Ser Val Ser Val Tyr 
            500                 505                 510         


Thr Asn Gly Thr Val Phe Ala Thr Asp Thr Asp Ile Thr Phe Thr Ala 
        515                 520                 525             


Val Thr Lys Glu Thr Ile Pro Leu Glu Phe Glu Trp Tyr Phe Gly Glu 
    530                 535                 540                 


Asp Pro Pro Val Arg Thr Thr Ser Arg Ser Ile Lys Lys Arg Leu Ser 
545                 550                 555                 560 


Ile Pro Gln Trp Tyr Arg Val Met Val Lys Ala Ser Asn Arg Met Ser 
                565                 570                 575     


Ser Val Val Ser Glu Pro His Val Ile Arg Val Gln Lys Lys Ile Val 
            580                 585                 590         


Ala Asn Arg Leu His His His His His His His His His His 
        595                 600                 605     


<210>  20
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  20

Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
1               5                   


<210>  21
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  21

Gln Ala Val Asp Asn Leu Thr Ser Ala Pro Gly Asn Thr Ser Leu Cys 
1               5                   10                  15      


Thr Arg Asp Tyr Lys Ile Thr Gln 
            20                  


<210>  22
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  22

Met Val Trp Arg 
1               


<210>  23
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  23

Thr Glu Gly Leu Leu Pro Leu Glu Glu 
1               5                   


<210>  24
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  24

Thr Ser Pro Arg Gln Ala Val Cys Leu Thr Arg Met 
1               5                   10          


<210>  25
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  25

Leu Thr Ala Phe Gly Ala Ser Leu Phe Val Pro Pro Ser His 
1               5                   10                  


<210>  26
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  26

Arg Glu Trp Lys 
1               


<210>  27
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  27

Ser Glu Arg Phe Ser Pro Gln Pro Gly 
1               5                   


<210>  28
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  28

Thr Ser Pro Glu Lys Val Asn Cys Ser Tyr His Arg 
1               5                   10          


<210>  29
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  29

Leu Ala Ala Phe Ala Leu Leu Arg Arg Lys Leu Lys Ala Ser 
1               5                   10                  


<210>  30
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  30

Gln Glu Thr Trp Asp 
1               5   


<210>  31
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  31

Asp Ser Gly Cys Gln Val Gly Pro Arg 
1               5                   


<210>  32
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  32

Thr Ser Pro Tyr Gln Thr His Cys Leu Cys Asn Met 
1               5                   10          


<210>  33
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  33

Leu Thr Phe Phe Gly Ser Thr Phe Leu Val Met Pro Asn Ala 
1               5                   10                  


<210>  34
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  34

Asn Gln Thr Trp Ser 
1               5   


<210>  35
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  35

Ser Ala Gly Cys Gln Val Gly Pro Gln 
1               5                   


<210>  36
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  36

Ser Thr Ile Leu Arg Thr Gln Cys Leu Cys Asn Met 
1               5                   10          


<210>  37
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  37

Leu Thr Phe Phe Ala Ser Asp Phe Phe Val Val Pro Arg Thr 
1               5                   10                  


<210>  38
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  38

Gln Ser Glu Trp Arg 
1               5   


<210>  39
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  39

Glu Gly Tyr Cys Ile Leu Gly Glu Lys 
1               5                   


<210>  40
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  40

Thr Ser Trp Tyr Glu Val His Cys Ile Cys Lys Asn 
1               5                   10          


<210>  41
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  41

Val Val Arg Ala Arg Arg Gln Leu Gly Thr Ile Gly Leu Thr 
1               5                   10                  


<210>  42
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  42

Asp Tyr Lys Asp Asp Asp Asp Lys 
1               5               


<210>  43
<211>  120
<212>  PRT
<213>  Homo sapiens

<400>  43

His Phe Arg Trp Ser Ala Leu Gln Val Ser Val Gly Leu Tyr Thr Ser 
1               5                   10                  15      


Leu Cys Gln Tyr Phe Ser Glu Glu Asp Met Val Trp Arg Thr Glu Gly 
            20                  25                  30          


Leu Leu Pro Leu Glu Glu Thr Ser Pro Arg Gln Ala Val Cys Leu Thr 
        35                  40                  45              


Arg His Leu Thr Ala Phe Gly Ala Ser Leu Phe Val Pro Pro Ser His 
    50                  55                  60                  


Val Arg Phe Val Phe Pro Glu Pro Thr Ala Asp Val Asn Tyr Ile Val 
65                  70                  75                  80  


Met Leu Thr Cys Ala Val Cys Leu Val Thr Tyr Met Val Met Ala Ala 
                85                  90                  95      


Ile Leu His Lys Leu Asp Gln Leu Asp Ala Ser Arg Gly Arg Ala Ile 
            100                 105                 110         


Pro Phe Cys Gly Gln Arg Gly Arg 
        115                 120 


<210>  44
<211>  120
<212>  PRT
<213>  Mus musculus

<400>  44

His Phe His Trp Ser Ala Leu Glu Val Ser Val Gly Leu Tyr Thr Ser 
1               5                   10                  15      


Leu Cys Gln Tyr Phe Ser Glu Glu Met Met Met Trp Arg Thr Glu Gly 
            20                  25                  30          


Ile Val Pro Leu Glu Glu Thr Ser Pro Ser Gln Ala Val Cys Leu Thr 
        35                  40                  45              


Arg His Leu Thr Ala Phe Gly Ala Ser Leu Phe Val Pro Pro Ser His 
    50                  55                  60                  


Val Gln Phe Ile Phe Pro Glu Pro Ser Ala Ser Ile Asn Tyr Ile Val 
65                  70                  75                  80  


Leu Leu Thr Cys Val Ile Cys Leu Val Thr Tyr Val Val Met Ala Met 
                85                  90                  95      


Ile Leu Arg Lys Leu Asp Gln Leu Asp Val Ser Arg Val Arg Val Ile 
            100                 105                 110         


Pro Phe Cys Gly Lys Gly Gly Arg 
        115                 120 


<210>  45
<211>  120
<212>  PRT
<213>  Rattus norvegicus

<400>  45

His Phe His Trp Ser Ala Leu Glu Val Ser Val Gly Leu Tyr Thr Ser 
1               5                   10                  15      


Leu Cys Gln Tyr Phe Ser Glu Glu Ala Met Met Trp Arg Thr Glu Gly 
            20                  25                  30          


Ile Val Pro Leu Glu Glu Thr Ser Pro Ser Gln Ala Val Cys Leu Thr 
        35                  40                  45              


Arg His Leu Thr Ala Phe Gly Ala Ser Leu Phe Val Pro Pro Ser His 
    50                  55                  60                  


Val Gln Phe Ile Phe Pro Glu Pro Ser Val Ser Ile Asn Tyr Ile Val 
65                  70                  75                  80  


Leu Leu Thr Cys Val Ile Cys Leu Val Thr Tyr Val Ile Met Ala Met 
                85                  90                  95      


Ile Leu Arg Lys Leu Asp Gln Leu Asp Val Ser Arg Val Arg Val Ile 
            100                 105                 110         


Pro Phe Cys Gly Lys Gly Gly Arg 
        115                 120 


<210>  46
<211>  120
<212>  PRT
<213>  Homo sapiens

<400>  46

Arg Tyr Leu Ala Lys Ala Val Asn Tyr Thr Val His Phe Gln Trp Ile 
1               5                   10                  15      


Arg Cys Leu Phe Trp Asp Lys Arg Glu Trp Lys Ser Glu Arg Phe Ser 
            20                  25                  30          


Pro Gln Pro Gly Thr Ser Pro Glu Lys Val Asn Cys Ser Tyr His Arg 
        35                  40                  45              


Leu Ala Ala Phe Ala Leu Leu Arg Arg Lys Leu Lys Ala Ser Phe Glu 
    50                  55                  60                  


Val Ser Asp Ile Ser Lys Leu Gln Ser His Pro Glu Asn Leu Leu Pro 
65                  70                  75                  80  


Ser Ile Phe Ile Met Gly Ser Val Ile Leu Tyr Gly Phe Leu Val Ala 
                85                  90                  95      


Lys Ser Arg Gln Val Asp His His Glu Lys Lys Lys Ala Gly Tyr Ile 
            100                 105                 110         


Phe Leu Gln Glu Ala Ser Leu Pro 
        115                 120 


<210>  47
<211>  120
<212>  PRT
<213>  Mus musculus

<400>  47

Lys Tyr Leu Ala Gly Ala Val Asn Tyr Thr Val His Phe Gln Trp Ile 
1               5                   10                  15      


Gln Cys Val Phe Trp Asp Lys Thr Glu Trp Arg Ser Glu Gly Pro Tyr 
            20                  25                  30          


Pro Gln Pro Gly Ser Ser Pro Glu Lys Val Asn Cys Ser Tyr His His 
        35                  40                  45              


Leu Ala Pro Val Ser Val Leu Arg Arg Lys Leu Asn Ala Thr Leu Glu 
    50                  55                  60                  


Val Ser Ser Ile Ser Glu Phe Gln Ser His Pro His Asn Leu Leu Pro 
65                  70                  75                  80  


Gly Ile Phe Ser Ala Phe Leu Leu Val Leu Tyr Gly Ile Leu Val Ser 
                85                  90                  95      


Lys Ser Arg Tyr Val Asp Cys His Glu Lys Lys Asn Pro Gly Phe Ile 
            100                 105                 110         


Phe Leu Glu Glu Asp Thr Leu Pro 
        115                 120 


<210>  48
<211>  120
<212>  PRT
<213>  Rattus norvegicus

<400>  48

Lys Tyr Leu Ala Gly Ala Val Asn Tyr Thr Val His Phe Gln Trp Ile 
1               5                   10                  15      


Gln Cys Val Phe Trp Asp Lys Thr Glu Trp Arg Ser Glu Gly Pro Cys 
            20                  25                  30          


Pro Gln Pro Gly Thr Ser Pro Glu Lys Val Asn Cys Ser Tyr His Arg 
        35                  40                  45              


Leu Ala Pro Phe Ser Val Leu Arg Arg Lys Leu Asn Ala Thr Phe Gln 
    50                  55                  60                  


Val Ser Ser Val Ser Glu Phe Gln Ser His Pro His Asn Leu Leu Pro 
65                  70                  75                  80  


Ser Ile Phe Ser Val Phe Phe Leu Val Leu Tyr Gly Phe Leu Met Ser 
                85                  90                  95      


Lys Ser Ser Cys Val Asp Cys His Lys Lys Lys Asp Pro Gly Cys Ile 
            100                 105                 110         


Phe Leu Glu Glu Glu Thr Leu Leu 
        115                 120 


