                         SEQUENCE LISTING

<110>  Pioneer Hi-Bred International Inc.
       Cigan, Andrew  Mark
       King, Matt
       Lin, Helen
       Young, Joshua K
 
<120>  NOVEL CAS9 SYSTEMS AND METHODS OF USE

<130>  BB2398 PCT

<150>  62/306904
<151>  2016-03-11

<160>  207   

<170>  PatentIn version 3.5

<210>  1
<211>  7342
<212>  DNA
<213>  Bacillus cereus

<220>
<221>  misc_feature
<222>  (5412)..(5467)
<223>  n is a, c, g, or t

<400>  1
acgaaggatc attttaaaaa aactgaacaa tcataatcaa caatactgtt aaaatcggac       60
cactaaggct aaataatgtc gaaatgaatt tagagttatt atattgcgac ataaaaaaga      120
taaccgaacc caaaatagta ataataggta caatgattgc tctcatagca aggaaataga      180
gtggaacggc gaaaatactt cctaatacga tgaaaaaaaa tgtacaaaga tgccaactta      240
ttattgttct ttttcgaaaa atataaagta aaaaccaccc aaagatacaa caaacataat      300
taaataaggt aacaaaccaa agaatactct gaaaactcga tgttcttaaa tcagtaaaat      360
caatcgtagg acttaataca tatataaaca aaataattag attagcaaaa aacagggata      420
atcctgctcc agacaagtat gatcgcattt aaatcataac ccccttacat taatattaat      480
tattatacca taaaatgggt tttgtttaat ggttcttaat cttactaacg tgtaaatttt      540
gaaatgttag gtttttaaat aagagtataa acatcgggca attggcagat gaactaaggg      600
tagctaggga acaggagaaa aagaacgaag gctaggttat taacgtgtca taattttcaa      660
taataaatat ataaaataaa tatataaaat aaatatataa aataaatata taaatgagat      720
tgacttcgat gatatatgga tataaaatga aagtatcata tcatatcaag ttttggtaag      780
ttgctatagt aagggcaaca gacccgaggc gttggggatc gcctagcccg tttttacggg      840
ctctccctat attcaaaata atgacaaacg agcaccttgg agaatttatt tccgaggtgc      900
ttttttttct aggagggata gaatggcata cacaatggga atagatgtgg ggattgcttc      960
gtgtggatgg gctattgtag atcttgaaag acaacgaata atagatctag gtgttcggac     1020
ttttgagaaa gcagagaatc cgaaaaatgg agaggctctt gctgtaccaa ggagagaagc     1080
tagatcgagc cgtaggagat tacggagaaa aaaacatcgc attgaaagat taaagcatat     1140
gtttattcgg aatggactgg cggttgatat tcaacatctt gagcagcaga cgttacgtag     1200
ccaaaatgaa atagatgtat ggcaattacg agtagatggt ttggatcgaa tgctaactca     1260
aaaagagtgg cttcgtgtat taattcatct tgcacaacgt cgtggttttc aatcaaatcg     1320
aaaaacagat ggttcaagtg aagatgggca ggttcttgta aatgtaacgg agaatgacag     1380
attaatggaa gagaaagatt atcgaaccgt agcggaaatg atggtaaaag atgaaaaatt     1440
ctctgaccat aagcgaaata aaaatggaaa ttatcatgga gtagtgagca gagcttcttt     1500
attagttgaa atacatacat tatttgaatc ccaaagacag caccataatt ttttggcatc     1560
gaaagatttc gagctggaat atgttaatat ttggtcttca caacggcctg ttgcaacaaa     1620
agatcaaata gaaaaaatga ttggtacatg tactttctta ccgaaagaaa agagaactcc     1680
aaaggcatct tggcattttc aatattttat gctcttgcaa acgatcaatc atatccgtat     1740
aacaaatata caaggcacga gatcattgaa taaagaagaa attgaacaag tggtcaatat     1800
ggcacttacc aaatcaaagg tatcttacca tgatattaga aaagtccttg atttatcaga     1860
agaatatcaa tttgttggct tggattatgg aaaagagaat gaaaaaaaga aagttgaaag     1920
taaggaaacg atcatcaaat tagatgatta ccataagtta aataaaattt ttaatgaagt     1980
ggaattagct aaaggagaag cttggaaagc tgttgattat gatacagtag cgtatgctct     2040
cactttcttt aaagatgatg aagatattag agattatttg caaaataaat ataaagatag     2100
taaaaatcgt cttgttaaga acgtagctaa taaagaatac acaaatgaat tggtagaaaa     2160
agtgagtacg ctatcttttc gtaaagtggg gcatttatca ttgaaagcct tacgaaagat     2220
catcccgttt ttggagcaag gcatgaccta tgataaagcg tgccaagcgg ctggttttaa     2280
ctttcaaggt atatcaaaaa agaagagatc tgttgtcttg ccggtcattg accaaatttc     2340
caacccagta gtaaatcgtg ctcttactca aacgcgtaaa gtaattaatg ctctaatcaa     2400
aaaatatggt tcacctgaaa ccatacacat tgaaacagca agagagttat caaagagatt     2460
tgatgaacga aagaatatta ctaaggatta taaggagaat agagacaaga acgaacgtgc     2520
aaaaaaacac ttatcggaat tagggattat taatcctact ggtcttgata tagtaaagta     2580
caagctgtgg tgtgagcaac aagggcgctg tatgtacagc aaccaaccca tctcctttga     2640
aagactgaga gaatcaggtt ataccgaggt agatcacatt attccataca gccgaagtat     2700
gaatgatagt tataacaatc gcgtattggt tatgactagg gaaaatcgtg aaaagagtaa     2760
tcaaactcct tatgaatata tgggtaatga tacgcaaaga tgggatgagt ttgaacaaag     2820
agtcacaaca aatccacaaa taaaaaagga gaaacgacag aacctcttgc taaaaggatt     2880
cactaatcgt cgggaattag aaatgttaga aagaaactta aatgatacac gttatataac     2940
taagtatctt tcacatttta ttagtacgaa tttggaattc tctcctagtg ataaaaagaa     3000
aaaggtagtt aatacaagcg gtcgtatcac ttcccattta agaagtagat ggggattaga     3060
aaaaaatcgt gagcaaaatg atttacacca tgcaatggac gcggttgtaa ttgctgtcac     3120
ctcagactcg tttattcaac aggtaacgaa ctactataaa cggaaagaaa gaagagagtt     3180
gaatagggat gataagttcc ctctaccttg gaagtttttt agagaagaag tcatagcaag     3240
attaagccct aatccaaaag aacaaattga agcattgccc aaccattttt atagcgaaga     3300
tgaacttgct gatcttcaac cgatttttgt gtcaagaatg cccaagcgta gtataactgg     3360
agaggcgcat caggcacagt ttcgccgagt tgtgggtaaa acgaaagagg gtaaaaatat     3420
tactgcaaag aaaactgctt tagttgatat tagctatgat aaaaatggtg attttaatat     3480
gtatggaaga gaaacagatc ctgctactta tgaagcaatt aaagaaagat atctcgaatt     3540
tggaggaaat gctaaaaaag cattttcaac ggatttacat aaaccgaaaa aagatggcac     3600
caaagggcca ctgataaaat ctgtgagaat aatggaaaat aaaacattgg tacatcccgt     3660
aaataaagga aaaggtgttg tgtataacag ctctattgta aggacagatg tatttcaaag     3720
aaaagagaaa tattatttac tacctgtgta cgtaacagat gtaaccaaag ggaaactacc     3780
aaataaggtg attgttgcta aaaagggata cgatgattgg attgaggttg atgatagctt     3840
cacattttta tacagtctat atccgaatga tttaatattc atcagacaaa atccaaaaaa     3900
gaaaatatca ttaaaaaaac gtattgagag tcattctatt tctgatagta aagaggttca     3960
agaaattctt gcctattata aaggggttga tagttcaact gctgctatag agtttattac     4020
tcatgatggt agttactatg caaaaggtgt tggtgtccaa aatctagatt gttttgaaaa     4080
atatcaagtt gatactctgg gtaattattc caaagtgaaa ggagaaaaac gacttgagtt     4140
ggagacatct gataataacg acaaaggcaa agatgtcaat tcgattaaat caactagtcg     4200
ttaaacaaga agaagaggtt accatacctc ttgaagatat cgcatctatt gtggttgaag     4260
aaaatcaagt tgtgttaaca gctgctctat taagtaaatg cagtgaatat ggaattggtt     4320
tgtatacttg cgatgaaaag catttaccca atggtttgtt acttcccttt cagagtcatt     4380
caaggcaatt aagggtactt gaaacccaat ataacctttc aaagccattt aaaaaaagag     4440
tgtggcaaaa aataattaca actaagataa tgaatcaagc attgtgctta tcttatttgg     4500
ataaaaccgg agaaagtgaa ctgcttgcaa ttcgcaatac cgttgattca ggtgactcta     4560
cgaatagaga ggcatatgct gctaaagttt attttcaaca tttgtttggg aaacggttta     4620
ttcgaaggga agaccatata ataaaccact ccctcaatta tggttattcg atccttagag     4680
gaaatgtagc tagagtttta gtacagtatg gattctttcc atgtctagga attgaccatc     4740
acaatgaaaa taacgcattt aatttagctg atgattttat ggaggttttt cgcccattgg     4800
ttgatttatt tgtcgtgaaa cattttcatg aggagatgga atttacaccg aagtggagag     4860
caggattgta taatgtagtg aatcatcaag ttgaactaga aggtgaaaga tattcctgta     4920
atcgagctat tgaagaaatg attaaaagct acgttacagc atgcagaaca aatatgtatg     4980
agagactgag aacaccaaca ttactccctt tgaagattca ttcatatgag taaatatatg     5040
cgaatacttg tcttttttga tctaccggtg aaaaggaagc aggatcgtaa ggcttactgt     5100
gcatttagaa agtttttaat agcagatgga tatgatatgc tccagttttc agtctattct     5160
cgaatttgta atggcaatga aggaacacat aagcatttgg aaaggctgtc acgtaatttg     5220
ccctcaaagg gttcggtacg atcgttgatt attactgaaa agcaatatga aaagatgaaa     5280
ttttttgttg ggaaaccaaa aataaaagaa gagaaagtaa acagtgtgca actaacattt     5340
ttctgaaaaa gaaaattatt aataggaaga aaggagtttt tcttaccttt ttaaaatacc     5400
aaaagccttg annnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn     5460
nnnnnnnctt tcaaggcttt ttgggcacgt atcatatcat atcgagtttt agtaaggaac     5520
tatagcagaa acggattagt caatttgtcg atatgatcat atcatatcga gttttagtaa     5580
ggaactatag ctgttctgat ggaatgaact ggactttcgt catcatatca tatcgagttt     5640
tagtaaggaa ctatagcctt tatgggcggt cactgccggg atattcaatc atatcatatc     5700
gagttttagt aaggaactat agctttaatc attgcagttg ctaagaaaat tctatcatat     5760
catatcgagt tttagtaagg aactatagca gtcgtataca agtatggact ctcgaaatga     5820
tcatatcata tcgagtttta gtaaggaact atagcatgga tttttagttt gattcccgat     5880
atgaaatcat atcatatcga gttttagtaa ggaactatag cttggggtca cgtataatca     5940
aaccacgatc aatcatatca tatcgagttt tagtaaggaa ctatagcaga atcagcaaga     6000
tcactacgaa agcgaaaatc atatcatatc gagttttagt aaggaactat agctttcttt     6060
gctcccttct ccattcttgg tgaatcatat catatcgagt tttagtaagg aactatagca     6120
acgaaacaac cggggtgtca tctatattta tcatatcata tcgagtttta gtaaggaact     6180
atagcgcgag aggatgagga cggactttat cgtttatcat atcatatcga gttttagtaa     6240
ggaactatag cttacgatgc tatttcgatg ggggatggtt tatcatatca tatcgagttt     6300
tagtaaggaa ctatagccat gacgttagac cagttgaaag atttttgatc atatcatatc     6360
gagttttagt aaggaactat agcaatcgtg ctggattgga tcgctggata tcgatcatat     6420
catatcgagt tttagtaagg aactatagca cggtgccagc agggaaagcg gccagaagaa     6480
tcatatcata tcgagtttta gtaaggaact atagcaactc cagccctatg caaaggctgt     6540
atgggatcat atcatatcga gttttagtaa ggaactatag cacagttaga tatatactgt     6600
caggtatctt tatcatatca tatcgagttt tagtaaggaa ctatagctta gattgctcta     6660
actgatttag ctgaagcatc atatcatatc gagttttagt aaggaactat ggtctattgg     6720
gtattatcca aatcactatc ctactcaaac cccagacgga tagtcttttt tattaataaa     6780
catgtaattt tacccattgc ttaatctcct catcatttaa taaaatagga acacacattc     6840
gtatttaggg agatgtttta atggctagta aaattcttga cccacttgta acgaagttta     6900
ttttgccaga acatgcagaa atgttacgtc agtatcatga ggataagaag ctgatcgaga     6960
agccgttcat tgaagaggat gagctggccg agttttgcta caggatatct gactcacgtc     7020
agtatgacta tgcattaacc attagttggt ggaaagaggc aaaagaaggt agaggcgtga     7080
tagaatccgc ttggggatgg gtagataagt ttgattctca atttaaacag attaagctaa     7140
aaaacgatga ggatttctgg tggattcctg tagaagatgt agtgagtgtg gaagcctaag     7200
cagagaatct tataactgca tatagtgtat tgcctgtggg aacagggata cagcaaacac     7260
cccactatta atagcctagt ggggtgtttg catttaacat tcaatagcgt tgcaagcggt     7320
tcggcttatt cattgcatca at                                              7342

<210>  2
<211>  7342
<212>  DNA
<213>  Brevibacillus laterosporus

<220>
<221>  misc_feature
<222>  (5412)..(5467)
<223>  n is a, c, g, or t

<400>  2
acgaaggatc attttaaaaa aactgaacaa tcataatcaa caatactgtt aaaatcggac       60
cactaaggct aaataatgtc gaaatgaatt tagagttatt atattgcgac ataaaaaaga      120
taaccgaacc caaaatagta ataataggta caatgattgc tctcatagca aggaaataga      180
gtggaacggc gaaaatactt cctaatacga tgaaaaaaaa tgtacaaaga tgccaactta      240
ttattgttct ttttcgaaaa atataaagta aaaaccaccc aaagatacaa caaacataat      300
taaataaggt aacaaaccaa agaatactct gaaaactcga tgttcttaaa tcagtaaaat      360
caatcgtagg acttaataca tatataaaca aaataattag attagcaaaa aacagggata      420
atcctgctcc agacaagtat gatcgcattt aaatcataac ccccttacat taatattaat      480
tattatacca taaaatgggt tttgtttaat ggttcttaat cttactaacg tgtaaatttt      540
gaaatgttag gtttttaaat aagagtataa acatcgggca attggcagat gaactaaggg      600
tagctaggga acaggagaaa aagaacgaag gctaggttat taacgtgtca taattttcaa      660
taataaatat ataaaataaa tatataaaat aaatatataa aataaatata taaatgagat      720
tgacttcgat gatatatgga tataaaatga aagtatcata tcatatcaag ttttggtaag      780
ttgctatagt aagggcaaca gacccgaggc gttggggatc gcctagcccg tttttacggg      840
ctctccctat attcaaaata atgacaaacg agcaccttgg agaatttatt tccgaggtgc      900
ttttttttct aggagggata gaatggcata cacaatggga atagatgtgg ggattgcttc      960
gtgtggatgg gctattgtag atcttgaaag acaacgaata atagatctag gtgttcggac     1020
ttttgagaaa gcagagaatc cgaaaaatgg agaggctctt gctgtaccaa ggagagaagc     1080
tagatcgagc cgtaggagat tacggagaaa aaaacatcgc attgaaagat taaagcatat     1140
gtttattcgg aatggactgg cggttgatat tcaacatctt gagcagcaga cgttacgtag     1200
ccaaaatgaa atagatgtat ggcaattacg agtagatggt ttggatcgaa tgctaactca     1260
aaaagagtgg cttcgtgtat taattcatct tgcacaacgt cgtggttttc aatcaaatcg     1320
aaaaacagat ggttcaagtg aagatgggca ggttcttgta aatgtaacgg agaatgacag     1380
attaatggaa gagaaagatt atcgaaccgt agcggaaatg atggtaaaag atgaaaaatt     1440
ctctgaccat aagcgaaata aaaatggaaa ttatcatgga gtagtgagca gagcttcttt     1500
attagttgaa atacatacat tatttgaatc ccaaagacag caccataatt ttttggcatc     1560
gaaagatttc gagctggaat atgttaatat ttggtcttca caacggcctg ttgcaacaaa     1620
agatcaaata gaaaaaatga ttggtacatg tactttctta ccgaaagaaa agagaactcc     1680
aaaggcatct tggcattttc aatattttat gctcttgcaa acgatcaatc atatccgtat     1740
aacaaatata caaggcacga gatcattgaa taaagaagaa attgaacaag tggtcaatat     1800
ggcacttacc aaatcaaagg tatcttacca tgatattaga aaagtccttg atttatcaga     1860
agaatatcaa tttgttggct tggattatgg aaaagagaat gaaaaaaaga aagttgaaag     1920
taaggaaacg atcatcaaat tagatgatta ccataagtta aataaaattt ttaatgaagt     1980
ggaattagct aaaggagaag cttggaaagc tgttgattat gatacagtag cgtatgctct     2040
cactttcttt aaagatgatg aagatattag agattatttg caaaataaat ataaagatag     2100
taaaaatcgt cttgttaaga acgtagctaa taaagaatac acaaatgaat tggtagaaaa     2160
agtgagtacg ctatcttttc gtaaagtggg gcatttatca ttgaaagcct tacgaaagat     2220
catcccgttt ttggagcaag gcatgaccta tgataaagcg tgccaagcgg ctggttttaa     2280
ctttcaaggt atatcaaaaa agaagagatc tgttgtcttg ccggtcattg accaaatttc     2340
caacccagta gtaaatcgtg ctcttactca aacgcgtaaa gtaattaatg ctctaatcaa     2400
aaaatatggt tcacctgaaa ccatacacat tgaaacagca agagagttat caaagagatt     2460
tgatgaacga aagaatatta ctaaggatta taaggagaat agagacaaga acgaacgtgc     2520
aaaaaaacac ttatcggaat tagggattat taatcctact ggtcttgata tagtaaagta     2580
caagctgtgg tgtgagcaac aagggcgctg tatgtacagc aaccaaccca tctcctttga     2640
aagactgaga gaatcaggtt ataccgaggt agatcacatt attccataca gccgaagtat     2700
gaatgatagt tataacaatc gcgtattggt tatgactagg gaaaatcgtg aaaagagtaa     2760
tcaaactcct tatgaatata tgggtaatga tacgcaaaga tgggatgagt ttgaacaaag     2820
agtcacaaca aatccacaaa taaaaaagga gaaacgacag aacctcttgc taaaaggatt     2880
cactaatcgt cgggaattag aaatgttaga aagaaactta aatgatacac gttatataac     2940
taagtatctt tcacatttta ttagtacgaa tttggaattc tctcctagtg ataaaaagaa     3000
aaaggtagtt aatacaagcg gtcgtatcac ttcccattta agaagtagat ggggattaga     3060
aaaaaatcgt gagcaaaatg atttacacca tgcaatggac gcggttgtaa ttgctgtcac     3120
ctcagactcg tttattcaac aggtaacgaa ctactataaa cggaaagaaa gaagagagtt     3180
gaatagggat gataagttcc ctctaccttg gaagtttttt agagaagaag tcatagcaag     3240
attaagccct aatccaaaag aacaaattga agcattgccc aaccattttt atagcgaaga     3300
tgaacttgct gatcttcaac cgatttttgt gtcaagaatg cccaagcgta gtataactgg     3360
agaggcgcat caggcacagt ttcgccgagt tgtgggtaaa acgaaagagg gtaaaaatat     3420
tactgcaaag aaaactgctt tagttgatat tagctatgat aaaaatggtg attttaatat     3480
gtatggaaga gaaacagatc ctgctactta tgaagcaatt aaagaaagat atctcgaatt     3540
tggaggaaat gctaaaaaag cattttcaac ggatttacat aaaccgaaaa aagatggcac     3600
caaagggcca ctgataaaat ctgtgagaat aatggaaaat aaaacattgg tacatcccgt     3660
aaataaagga aaaggtgttg tgtataacag ctctattgta aggacagatg tatttcaaag     3720
aaaagagaaa tattatttac tacctgtgta cgtaacagat gtaaccaaag ggaaactacc     3780
aaataaggtg attgttgcta aaaagggata cgatgattgg attgaggttg atgatagctt     3840
cacattttta tacagtctat atccgaatga tttaatattc atcagacaaa atccaaaaaa     3900
gaaaatatca ttaaaaaaac gtattgagag tcattctatt tctgatagta aagaggttca     3960
agaaattctt gcctattata aaggggttga tagttcaact gctgctatag agtttattac     4020
tcatgatggt agttactatg caaaaggtgt tggtgtccaa aatctagatt gttttgaaaa     4080
atatcaagtt gatactctgg gtaattattc caaagtgaaa ggagaaaaac gacttgagtt     4140
ggagacatct gataataacg acaaaggcaa agatgtcaat tcgattaaat caactagtcg     4200
ttaaacaaga agaagaggtt accatacctc ttgaagatat cgcatctatt gtggttgaag     4260
aaaatcaagt tgtgttaaca gctgctctat taagtaaatg cagtgaatat ggaattggtt     4320
tgtatacttg cgatgaaaag catttaccca atggtttgtt acttcccttt cagagtcatt     4380
caaggcaatt aagggtactt gaaacccaat ataacctttc aaagccattt aaaaaaagag     4440
tgtggcaaaa aataattaca actaagataa tgaatcaagc attgtgctta tcttatttgg     4500
ataaaaccgg agaaagtgaa ctgcttgcaa ttcgcaatac cgttgattca ggtgactcta     4560
cgaatagaga ggcatatgct gctaaagttt attttcaaca tttgtttggg aaacggttta     4620
ttcgaaggga agaccatata ataaaccact ccctcaatta tggttattcg atccttagag     4680
gaaatgtagc tagagtttta gtacagtatg gattctttcc atgtctagga attgaccatc     4740
acaatgaaaa taacgcattt aatttagctg atgattttat ggaggttttt cgcccattgg     4800
ttgatttatt tgtcgtgaaa cattttcatg aggagatgga atttacaccg aagtggagag     4860
caggattgta taatgtagtg aatcatcaag ttgaactaga aggtgaaaga tattcctgta     4920
atcgagctat tgaagaaatg attaaaagct acgttacagc atgcagaaca aatatgtatg     4980
agagactgag aacaccaaca ttactccctt tgaagattca ttcatatgag taaatatatg     5040
cgaatacttg tcttttttga tctaccggtg aaaaggaagc aggatcgtaa ggcttactgt     5100
gcatttagaa agtttttaat agcagatgga tatgatatgc tccagttttc agtctattct     5160
cgaatttgta atggcaatga aggaacacat aagcatttgg aaaggctgtc acgtaatttg     5220
ccctcaaagg gttcggtacg atcgttgatt attactgaaa agcaatatga aaagatgaaa     5280
ttttttgttg ggaaaccaaa aataaaagaa gagaaagtaa acagtgtgca actaacattt     5340
ttctgaaaaa gaaaattatt aataggaaga aaggagtttt tcttaccttt ttaaaatacc     5400
aaaagccttg annnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn     5460
nnnnnnnctt tcaaggcttt ttgggcacgt atcatatcat atcgagtttt agtaaggaac     5520
tatagcagaa acggattagt caatttgtcg atatgatcat atcatatcga gttttagtaa     5580
ggaactatag ctgttctgat ggaatgaact ggactttcgt catcatatca tatcgagttt     5640
tagtaaggaa ctatagcctt tatgggcggt cactgccggg atattcaatc atatcatatc     5700
gagttttagt aaggaactat agctttaatc attgcagttg ctaagaaaat tctatcatat     5760
catatcgagt tttagtaagg aactatagca gtcgtataca agtatggact ctcgaaatga     5820
tcatatcata tcgagtttta gtaaggaact atagcatgga tttttagttt gattcccgat     5880
atgaaatcat atcatatcga gttttagtaa ggaactatag cttggggtca cgtataatca     5940
aaccacgatc aatcatatca tatcgagttt tagtaaggaa ctatagcaga atcagcaaga     6000
tcactacgaa agcgaaaatc atatcatatc gagttttagt aaggaactat agctttcttt     6060
gctcccttct ccattcttgg tgaatcatat catatcgagt tttagtaagg aactatagca     6120
acgaaacaac cggggtgtca tctatattta tcatatcata tcgagtttta gtaaggaact     6180
atagcgcgag aggatgagga cggactttat cgtttatcat atcatatcga gttttagtaa     6240
ggaactatag cttacgatgc tatttcgatg ggggatggtt tatcatatca tatcgagttt     6300
tagtaaggaa ctatagccat gacgttagac cagttgaaag atttttgatc atatcatatc     6360
gagttttagt aaggaactat agcaatcgtg ctggattgga tcgctggata tcgatcatat     6420
catatcgagt tttagtaagg aactatagca cggtgccagc agggaaagcg gccagaagaa     6480
tcatatcata tcgagtttta gtaaggaact atagcaactc cagccctatg caaaggctgt     6540
atgggatcat atcatatcga gttttagtaa ggaactatag cacagttaga tatatactgt     6600
caggtatctt tatcatatca tatcgagttt tagtaaggaa ctatagctta gattgctcta     6660
actgatttag ctgaagcatc atatcatatc gagttttagt aaggaactat ggtctattgg     6720
gtattatcca aatcactatc ctactcaaac cccagacgga tagtcttttt tattaataaa     6780
catgtaattt tacccattgc ttaatctcct catcatttaa taaaatagga acacacattc     6840
gtatttaggg agatgtttta atggctagta aaattcttga cccacttgta acgaagttta     6900
ttttgccaga acatgcagaa atgttacgtc agtatcatga ggataagaag ctgatcgaga     6960
agccgttcat tgaagaggat gagctggccg agttttgcta caggatatct gactcacgtc     7020
agtatgacta tgcattaacc attagttggt ggaaagaggc aaaagaaggt agaggcgtga     7080
tagaatccgc ttggggatgg gtagataagt ttgattctca atttaaacag attaagctaa     7140
aaaacgatga ggatttctgg tggattcctg tagaagatgt agtgagtgtg gaagcctaag     7200
cagagaatct tataactgca tatagtgtat tgcctgtggg aacagggata cagcaaacac     7260
cccactatta atagcctagt ggggtgtttg catttaacat tcaatagcgt tgcaagcggt     7320
tcggcttatt cattgcatca at                                              7342

<210>  3
<211>  5877
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Bacilllus species seqeunce

<400>  3
gcccaaaatg aagttaggtt catacataaa ttgtttggaa ttgcatcata atatgtcatt       60
gaacagttca tgtaggtttc aatgtctcta tcaaatgatt tttgcaccag aacccttttt      120
tatgttatac ccatttccac tgaaatttca agaaaaaatt gttataatac gagacattat      180
taatgattat tttaatggtt tttactctaa atcacagaga atattatacc agattcttgt      240
tattccttct gaagactacc catatttctg tgttttttat ttgaaaaatc tgatattttt      300
gttatgatag aggtatcatg gtacagcaat ggctttgatg tttctatgat aagggctttg      360
gcccgtggcg taggggatcg cctgcccatt ttaatgggct tctccccatc tatttaatga      420
gagttttaca accttggcta ttcttaaata gctaaggttt ttttgtatac atataaatta      480
aaagaggtga gattatgaga gagttggatt atcgcatcgg attagatatt ggaacgaatt      540
ctattggctg gggtgttatt gaattatctt ggaacaaaga tagagaacaa tatgagaaag      600
cgagaattgt cgacaagggt gttcgtatgt ttgataaggc tgaaatacct aagactggtg      660
cttctcttgc tgaaccgagg cgtatagcgc gctcatcacg tagaaggtta aatcgcaaaa      720
gccagagaaa aaaagatata cgtaatttac ttgttcaaca tgaaattatt agccaaaaag      780
aattagcttc gttatatcct ctgtcaaaaa gttcaatgga tatttgggat attcgtttgg      840
atggattaga tcgcttgtta gaccgttttg aatgggctcg actattaatt catttagcac      900
aaaaacgcgg ttttaaatca aatcgaaagt ctgaactgaa agatgtggag acaggaaaag      960
tattatcaag tattcaagca aatgaaaaac gattatctct gtaccgtaca gtgggagaga     1020
tgtggatgaa gaatatggat tttagtaaat atggcaaaag gcgtaattct cctaatgagt     1080
atgtattttc ggttagccgt gcagatttag aaaaggaaat tgtgactcta tttgaagcgc     1140
aaagaaaatt tcattcatca tatgcatcgg ttgatttaca aaaaacatat ttacgaattt     1200
gggcacacca actccctttt gcttctggga atgcaattgt aaataaagta ggatattgtt     1260
cattattaaa aggtaaagaa aagagagttc cgaaagcaac atatactttt caatatttca     1320
atacactaga tcaaataaac cgaacacgat tagggcctga tttccaacca tttacgaagg     1380
aacagagaga cattatttta gataaaatgt ttcaacggac agattattat aaaaaaaaga     1440
caatacccga agttacttac tatgatattc ggaaatggtt agcactagat gaaacaattc     1500
aatttaaagg acttacctat gacccaaacg aagagctgaa aaaaatagaa ttgaaaccct     1560
ttattaattt aaagccattt tatgaaatta aaaaggtagt tactaattac gcccaaaaaa     1620
caaatgaggt attctcaaca ttagactatg atacagttgc atatgcttta acagtttata     1680
aaacggacaa agatattaga tcttatttga agagatctaa taatttatca aaacgttgct     1740
atgatgatca attaatagaa gagctattaa ctctctccta tacaaagttt ggtcatttat     1800
catttaaagc aattaatcat gtactgccaa ttatgcaaga gggaaggact tatcaggaag     1860
caataaacca attaggatat gataccacta atcttaaaaa agaaaacaga agtatgttct     1920
tgcctcttat tccagatgag ataacaaatc caattgttaa aagagcgcta actcaagcac     1980
gtaaagttgt aaatgctatt attagaagat atggttctcc aaattctgtt catattgaac     2040
tagctcgtga gctttctaaa agtcatgacg agagaaagaa aataatgaca gctcatgatg     2100
aaaattataa gaaaaataaa ggagctatat caattttgat cgagaatgga attttaaatc     2160
cgacaggata tgatattgtg cgttataagt tatggaaaga gcaaggagaa cgatgtgctt     2220
attcgttaaa aaagattcct gctaatacgt tttttaatga attgaaaaaa gagcgaagtg     2280
gccctccggt tctagaggta gatcacattt taccgtatag tcagagtttt attgatagtt     2340
accataataa agtattagtt tatggggatg agaatcaaaa aaagggaaat cgaattccat     2400
atactttttt ttcagaagaa aataaggagt gggaaagctt tgaaagctac gtaagatcga     2460
atagtttttt ttctaaaaag aagcgcggat atttattgaa aaaagcttac ttgccaagag     2520
agagtaacct gattaaggag cgtcatttaa atgatacccg atatgctagt agctatttga     2580
aaaatttcat tgagaaaaat ttaaaattta aagaagctga aggtattaca cgaaaaaaac     2640
atgtacagac ggttaacggt gtaattacag cccatctgcg aaaaagatgg ggcttagaaa     2700
aagataggca ggaaacatat ttgcatcatg caatggacgc tattattgtt gcttgtacag     2760
atcatcatat ggtcactaaa gtaacggagt actatcaaat aaaagaaagt aataagtcaa     2820
taaagaaacc gtattttcct ttgccatgga tgggctttag agaggaaatt ttatcacatt     2880
tagaaagtca gccaattgct agaaaaatta gtgaggaact taaaattgga tatcaatcat     2940
ctgattatat acttgtatcg cgaatgccaa aaagatctgt cactggatca gctcatgacc     3000
agacagtcat gaaaaaaggc ggtatcgata aaaaaggaaa gactattatc ataaagcgtg     3060
tgcacttaaa ggatattaag tttgatgaga atggcgattt taaaatggtt ggaaaagaac     3120
aagatttagc aacttacgaa gcgataaagc aaagatattt agagtatgga aaagaatcga     3180
aaaaagcatt tgaaacacct ttatacaagc ctagtaaaaa aggaaaagga aacctcatta     3240
aaaaaattaa agtagaagtg caaaccaaat cttttgttcg agaagttaat gggggcgtag     3300
ctcaaaatgg tgatttagta agaatagatc tgtttgaaaa ggataatagg tattatatgg     3360
tacctattta cgtagtagat actgttcgtt ccgaactacc aaataaagct gtaaaaagca     3420
gtaaaggcta tgagcaatgg ctaacaatag ataacagctt tacgttcaaa ttcagtttat     3480
attcttatga tttagtacga cttgtaaaag gtgatgaaga tcgtttccta tactttagta     3540
ctcttgatat taattcggac cgtcttaatt ttaaagatgt aaataagcca tcaaagcagg     3600
ctgaatatcg ttatagtctt aaaacaattg agaatttaga aaaatatgag gttggtgttt     3660
taggtgattt aaggttagtg agacaagaaa cacgtaaaat tttttaatag ataaaaatta     3720
aagagatttt aacacggtaa gtaacattag tttgtttacc gtattttttt gtcttttttc     3780
gtctagaata ctagataata agtattacta ggagggattt aaatgggatg gcggcatgtt     3840
atgattacaa aaaatgctcg tttatctatt aagcattctc aattagttgt acaacaagaa     3900
gaaatagcaa caatcccact acaagatatt gcttctattc ttattgaaga tttagctgtt     3960
acgcttactg caagtgtact tagtaaatgt gccgagtata aaattagttt aattgcgtgt     4020
aattctaaga aacttccaaa tggtattttg actagttttt aacagcattc tcgccaattg     4080
acagttttga atatgcagtt aaatcttgca aaacctctta aaaaaaggat atggcaacaa     4140
attatttgcc gaaaaattat gaatcaagca ctttgtttag aatacttgaa ttgtggaggc     4200
gcatatgaat tgaataaaat tgtaaagacc gtagaatctg gagatacctc taatcgtgaa     4260
gcatatgcag caaagcaata ttttcgatat ttatttagtg attcttttac acgtcgttcc     4320
gaaaatccta taaaccggtt gttgaattat ggatacgcta ttataagaag tgcagtagca     4380
cgttcattaa ctaattatgg ttttttcaca tgtttaggaa ttcgtcataa taatcagtta     4440
aattcgttca atttagcaga cgatttcatg gaagtatttc gtcctatagt agatcaatac     4500
gtaattcaac aagacccaga aaactgggat ttctctgtac gtgcaggtct tgtgaattta     4560
ttaaacatag atgttaacat aaatggtgag ttgcgttcag ttacaacggc tattgatgat     4620
atggtaaaaa gttttatagc ttgttgtcgt caagaaacaa cttcttacct taaactacca     4680
gaattgctcc ctattagggt gcatcaatat gagtaaatat atgagaatct tattgttttt     4740
tgatttacct gtaaagacga aaacggaaag acgggattat gttcggttta gaaattattt     4800
actaaatgag gggtttgaca tgatacagtt ctctgtatat tgtcgtttat gtaatggtca     4860
tgaatctatg gagcgtcaat taggcaagat aaaaacaaga cttccgtcta aagggtctat     4920
cagagcatta cctgtaaccg aaaaacaatt tgagcggatg aggttattat taggagaaat     4980
aacaacaaac gaaagaagag tgaatattaa tcaattaaca ctgttctaat atgaacttac     5040
catgtataga aaaattttat catggaaaaa ctagtatgtt tgtgtataag gtaattatga     5100
aacggcaata ctgttaaata actatagttg ttcaaggact ctgttttatg aaaaacaaca     5160
aaatggagga taactcactc tatataggtt aaaaaataaa aaacagaaag cctgtaagca     5220
ttgatattac aggctttttt gaatacgtat cataatacag caatggcttt aatggaacta     5280
tgaccgtaaa gtagcttata gcaaacggac agtaatcata atacagcaat ggctttaatg     5340
gaactatgac aaaaaggcta ctcttaaatg tgtagtcttt atcataatac agcaatggct     5400
ttaatggaac tatgacgacc tttggcaggg aagttgcgag gaactgatca taatacagca     5460
atggctttaa tggaactatg accgatgcat caagtttaag gcgatcggat aaatcataat     5520
acagcaacgg ctttaatgga actatgacaa tttgttccaa tgatggaatg catatatgat     5580
caaaatgtct ctttaatttt acggagtaac tcaattcctt ttttatgtta taacaaatca     5640
tacgtattct tcaagcctga gtatattact ttgaaggtgt agcatgtgat ctgtccctta     5700
tctcagcaca aaactgttcc atctgttgtt ctgtgaattt ttcttctttt atatccccaa     5760
acgttgctga accaaggaat acttcatcat cacagttgat atcccaggac tcaaaaggtt     5820
tctctccttt tgaaactttc ttagtgaatc gcatccattc gccatcaatg tatacta        5877

<210>  4
<211>  5684
<212>  DNA
<213>  Bacillus cereus

<400>  4
agcttcaagc tttgcgtggt gagaattaag gttatcatag catagcgatg tttcttttgg       60
aactatagca gtttttcatc actatctgat actttcttaa tatcatagca tagcgatgtt      120
tcttttggaa ctatagccta gatggcttat ccctttcaga aggcttgatc atagcatagc      180
gatgtttctt ttggaactat agcaacatga cttggttgca ttacgaaagt ttcatcatag      240
catagcgatg tttcttgtgg aactatagca tcagctaaca tgcgtaagta atccctaata      300
tcatagcata gccatgtttc ttgtggaatt atagctcaga cttatcttcc ttcttcattt      360
cttgtatcac atcatagcga tgttttctat ggaattataa tctcacattg tacgtaatgc      420
aaaacataaa aattaaatca tagcatagcg atttttcttt tggaattata gtacttccct      480
aagtcttgca ggaaacatat taatcacatc atagcgatgt ttttttggaa ttatagctaa      540
actccaattg gagaactcca tttatttatc acatcgtagc gatgattctt ttggaattat      600
agattacagc ggtaaaatat tacatataaa attcatataa ctattattcc catttgcttc      660
atttttataa ttatacgttt atctaggtat aaagtttatt tttggtgtca ataatgaaac      720
tataaggatc atatcatagc gatgtttctt aagttattat agtaagggca atgacccgtg      780
gcgtttgggg atcgccttat cctgtatgga tattctcccc atgttaaaag cacctacgca      840
taacgctatg gtgcttttat tttgtaaaac atgaaggagg ttgttaattt gaaatacgta      900
ttaggattgg atattggaat cgcatcttgt ggttgggctg taataaatca agaaaaacat      960
agaattgaag atttaggggt acgtattttt gataaagctg agcaccctaa agatggaaaa     1020
tccttagcag caccaagacg tgaatctcgc tctactagga aaacacttcg tcgtaaaaaa     1080
catagaatgc aacgtatcaa agtactttta gttaagtatg gtttattatc tacgactgag     1140
attgaaaatt tatatgaaag tgctagtgaa attgatgttt ggaacctacg tttagatgct     1200
ctagaacgca agttaaatca aaaggaattt gcaagagtcc ttattcacct tgctaaaaga     1260
agaggattta aatctaacat gaaagaaaca attctctcag aaaacggaca aatcttagaa     1320
agtatttcag aaaatcaaaa gattatggag caacaaaatt atagaactgt tggagaaatg     1380
attgtaaaag ataacaagtt tgaaaaccat aaaagaaaca aagatggtac ttatatcggg     1440
actgttactc gtcaacaact tcaagatgaa atacatatga ttttcaatgc acaacgtttg     1500
tttataaatg accttgcaac agaggaattt gaaagtagct acttagaaat ttgggcatct     1560
caacgtccct atgcttctaa agatcaaatt gaaaaaatga ttggttactg taccttagaa     1620
ccaaaagaaa aaagagtccc taaagcttca tggtcatttc aatattttgt agcgctacaa     1680
accataaaca acctacgact gattagtaaa gacaggatag aagaactctc ttttgaagaa     1740
aagaaacaaa ttatgaatct agcacttgaa aaacctattg ttaaatacat tgatatccga     1800
aaattattat ccatttctaa tgaacttcat tttaacaatc tattatattc agctgataca     1860
gtagatacaa cggtggaaaa taaaaaatgt atagaactca aagaatatca ctctattaat     1920
aaggtatata aacaaattta tggaaagaac gccttaaatt tattacctat agattacgat     1980
acaattgcat acggactaac tatcttcaaa gacgataaag atatcctaga atacttacaa     2040
aataaatata taaatacaaa aggaaaaact ataagtaatt taacaaaaaa gacatacgat     2100
gacacgttta ttcaagcatt attgactttg aacttcacaa aaatgggaca tttatcattt     2160
aaagccttaa aaaatatcat tcctttttta gaagagggaa tgtcatatga taaagcttgt     2220
gataaggcag gatataactt taagggaaca tcatttacaa aaaaaacaaa gtacttgcct     2280
gttattccac agaatacaaa tcctgttgta catcgtgctc tttcacaaac aagaaaggtc     2340
ataaatgcaa ttataaataa atacggttct ccagtttcaa ttcatattga aaccgcaaga     2400
gagttatcta aaacattcca ggaaagaaaa gaaatagata gcatgtacca ggataactcc     2460
aaaaagaatg aacacgccat taataagcta aaagaattag gtaacattaa tccctcggga     2520
ataaatattg tcaaatttaa gctttggaag gaacaagacg gtagatgtat gtattccgga     2580
gaatatattg aaccacatcg attatttgaa gagggatata ccgaagtaga tcacatacta     2640
ccctatagtc gtagtttaga tgacagctat aacaataaaa cattagcttt aggaatagaa     2700
aatcaacgaa aagggaacaa aactccttat gagtacatgg ggaacacctc aatttggtac     2760
aaatttgaaa cgagggtaca gtcgaataaa aaaattaaca aaaagaaaca acaaaaattg     2820
cttctacaat acttttcgca tgcaagagag caagaattta tagagcgaaa tctaaatgat     2880
acccgttacg ccacaatata tatatcagcg tttattcaac aacacctcat tttctctgaa     2940
agcttcagta aaaaaagagt tcatacagtt agcggaatta taacatctca tgtacgtagt     3000
agatggggat ttaacaagga tcgtaaagaa agtcatatcc atcacgcatt agatgcagtg     3060
attgttgctg tcacatctga tcaaatgatt caaagagtaa caaattacta taaactaaaa     3120
gaattaaata gaaagcttca agccaaaggg atactgtttc ccgaaccttg ggaggggttt     3180
cgtttagaat tagaagcaag aatttctcca aatacccagc aatatttaaa gggaatttgt     3240
tctaaaaatt acgccgatat caatctatcc gaaatcaagc ctatctttgt ttcaagaatg     3300
cctaagcgat ctattactgg tgaattacat caagagacaa ttcgaaaatt tattggttat     3360
aacgaaaaag ggaaagtatt aaccgcaata aaaacaaagt tagaagatat tccttttgat     3420
gccaatggtg attttcctat gtatggaaaa gaaactgatt tgtatacgta taatgccatc     3480
aaagaacgtt atttaagtca taaaaaagat aaacgtaaat catttcaaga atccttatac     3540
aaacccacaa aaacaggaga aattgggcca cttataaaat ccattaaaat aattgataca     3600
agaaccattg tcaatcctgt taaccaaggt aaaggtgtcg tatataatag taaaattgct     3660
cgtactgatg tattcaaaaa agatgataag tactatttaa ttcccattta tacaattgac     3720
cttatgaaaa atgttttacc tcaaaaagca attacagcag gaaaaggata tgaagattgg     3780
ataaccattg atcatagctt tactttttta tttagccttt ttcctaatga cctaataaaa     3840
attgtcccct caaaaaataa agaaattaaa gctaggtcaa cttcatcaaa aaaagaaata     3900
ttactaccat cactcacagg atattttaag aaggttcata gtggaacagc aggcattact     3960
gttgaatccc acgatggtag gtttatagca gatataggct caaagcaatt attattattt     4020
gaaaaacacc aggtagatgt actgggacat tacacaaaaa taaaggagga aaaacgtatt     4080
gggatgtcga catgtaatga taacaaaaag agctcagctt tcggttcgct ataatcaact     4140
ggttataaag caagacgata aagtaagtat tcctttagag gatattgcct ctataattat     4200
agaagataat tcggtaacta tttcagccta tacacttagt aaattaagtg attataacat     4260
cgggttggtt acatgtaatg aaaaacactt accaaacggt atactaacat cttttcaaaa     4320
gcatacaaga cacgcaaaag ttcttcaaac acagtataac ttatccaagc ctttcagaaa     4380
aagaatatgg caaaaaatta ttatgaagaa gattatgaat caggctaagt gccttgaaat     4440
cttagaaaaa gagggatata aagaaatttt atcaatatgt aaaaccatag aatcaggaga     4500
tgtgaccaac agagaagcat atgcagcaaa actatatttc aaatatttat ttagtgcaca     4560
atttacaaga agaacagaaa acatatataa ctattcgtta aattatggat attcaataat     4620
acgtggaatg gttgcaagaa cattagttag ttatggtttc acaccctctc ttggaattaa     4680
acatcacaat gagttaaata attttaattt ggcagatgat tttatggaag tatttcgacc     4740
tatagttgat ttattcgtag cttcccatat agattattct acagaattta gtaaagaagt     4800
tcgaagaaac ttatacaaca tttcaaatta tgaaatacaa atcgacagta aatatcatag     4860
tattcaacaa gcaattgaag taatggtgaa aagttatgta tccgcttgtc gtacggaaga     4920
ttattgttta ataaaacttc ctaatttaat caaattaaga atgcattcat atgagtaatt     4980
tcatgcggat attagtcttt tttgacttac ctgtcaagca aaaaagtgaa cgaaaagaat     5040
atatgcgatt ccgtaaattc ctactcaatg atggatatga catgctacaa ttttcaattt     5100
actgtagaat ttgtaatggg aacgaaggta caaaaaaata tttagagcgc ttaaaatgca     5160
atgttcccga aaaaggttct attcgcacat taacgattac agataagcaa tatgctaaaa     5220
tggagttttt agtaggaaaa ccaacaccaa cagagaaaaa aataacttct gctcaactta     5280
cattatttta aaaagaaaaa gttggaacaa aaaacaaata taaaacctct tttttaaact     5340
taaaaacctt gtctatccct ttaatgacaa ggtttttttg acatctacca tatcatagcg     5400
atgtttctta tggaactata gctttattct atcgttcatc ataacaatgt aaaccatatc     5460
atagcgatgt ttcttatgga actatagcaa cacgtaatag aatcataagt gcagttacta     5520
ccatatcata gcgatgtttc ttatggaact atagctcgtc gcccataaac aaacttattc     5580
tttctgttat attatgataa tttttcttat gaaacagtat cctattagcc ttatttcacg     5640
aaaacccaaa tttcatagca gtattttcaa ataaaattac atct                      5684

<210>  5
<211>  8221
<212>  DNA
<213>  Lactobacillus fermentum

<400>  5
acgaccaacc gatcacgcct aagcaagtcg ggtccgtctt tgccctcggc acggtggcgg       60
tcctggtcgg ggcgatgacc aacctcggcg ttaactccag cggccaaacc gttacggtgg      120
ccgcccaacg ctcccagcta tcgacccagt acggggccaa gccagttgac ctggcgccgg      180
gcaagcaaat cagccaggtc gtcaagatca acggggcagc cagtgacgtc tccgtgcaga      240
tccacaccaa gtcacacgtt acggtgaccc tggtagaact aaaaactggt gacgaatacg      300
tcttcaagcg ccacgccgac gagtacgatt accaagggaa cgtgccagcc ggtacctacc      360
agttcgtgat caagaaccaa accgccgtgg accaagatgt tgacatcgcc cacgtcccgt      420
actaccggat ggcgccgtac ccgatggacg accagggaac ggtccactgg gacacgtcat      480
tgatctactg gttccgtgac gttcgctccg ccaattaaat agaattagaa aaccccagcc      540
gttcgggaaa ccgagggctg ggtttttggg tgggaagagg agaaaatttt gaattaggag      600
ggatttttgg gcgggcgaca gaatatgtcc gaggggtggg atactatgga gttagtcggc      660
aaacgcaaaa agaggtcgca aaatagtcgc tgatccttcg ttcaaattta tcaaaataac      720
tactgaaagc gattgcgttt gctataatct atcttgacta cgatattaag gagtggatta      780
cgtgaaagag tatcacattg gcttggacat tgggacaagc tcaattggct gggcggtaac      840
ggatagccaa tttaaactga tgcgtatcaa ggggaagacg gcaatcgggg tgcggttgtt      900
tgaagaaggg aagacggctg cagaacgtcg aaccttccgg acaacgcggc ggcggttgaa      960
gcggcgaaaa tggcgcttgc actacttaga taaaattttt gccccgcact tacaagaagt     1020
ggatgaaaat ttcttacgcc gtctgaagca atcaaatatc cacccggaag atccagcgaa     1080
gaatcaagcc ttcattggta agctcttatt tccggatcta ctgaagaaga atgaacgtgg     1140
ttacccaaca ctgattaaga tgcgcgatga attgccagtt gagcaacgcg cccactaccc     1200
agtaacgaac atctacaagt tacgggaggc catgattaac gaagatcgcc aattcgatct     1260
gcgggaagtt tacctggccg ttcaccacat cgtgaagtac cggggtcact tcttaaataa     1320
cgctagcgtt gataagttca aagtggggag aatcgatttt gacaaatcct ttaacgtttt     1380
gaacgaagcc tacgaggagc ttcaaaacgg cgaaggttca ttcacgattg agcctagcaa     1440
ggttgaaaaa attggacaac tgttgctaga tacgaagatg cgtaagttgg accgccaaaa     1500
agcggttgcc aaattgttag aggtgaaggt cgctgacaaa gaggagacca agcgcaacaa     1560
gcaaattgca acggcgatga gtaagttagt tcttggctac aaggcggact ttgcaacggt     1620
agcgatggcg aatggcaacg aatggaagat cgatttaagt tctgaaacca gtgaggacga     1680
gattgaaaaa ttccgggaag aattgagtga tgctcaaaat gatatcttaa cggaaatcac     1740
tagcctgttc tcgcagatca tgctgaatga aatcgtgcca aatgggatgt cgatttctga     1800
atcgatgatg gatcgttatt ggatgcacga acgtcaatta gcggaagtta aggaatactt     1860
ggcgacccaa ccagctagcg cgcggaaaga ttttgaccaa gtgtataaca aatacattgg     1920
gcaagcgcca aaggaaaagg gctttgacct tgaaaaggga ctcaagaaga ttttatccaa     1980
aaaggaaaat tggaaagaaa tcgatgagtt actcaaggca ggtgatttct taccaaagca     2040
acggacatca gccaatgggg tcatcccaca ccagatgcac caacaagaat tggaccgaat     2100
tattgaaaag caagctaagt actacccgtg gctagcaacg gaaaacccag ccactggtga     2160
acgtgatcgt caccaagcga agtatgaact tgatcagcta gtttccttcc ggattcctta     2220
ctatgttgga ccgctagtaa cgcctgaggt tcaaaaggcg acatctggcg ctaagtttgc     2280
ttgggcaaag cggaaagaag atggggagat taccccttgg aacctgtggg ataagattga     2340
ccgtgctgaa tcagctgaag cctttatcaa gcggatgacg gttaaggata cgtatctatt     2400
aaacgaggat gtcctgcctg ctaacagctt gctataccaa aagtacaacg tcttaaacga     2460
actaaacaac gttcgagtga atggacgccg cctatcagtc ggaattaaac aagatattta     2520
cactgagctc ttcaagaaga aaaagacggt gaaggcaggt gacgtggcca gcctagtgat     2580
ggcgaagaca cgaggagtta acaagccaag tgttgaaggt ttatccgatc cgaagaagtt     2640
caattcaaat ttggcaacct accttgatct aaagtcaatt gtgggtgaca aggttgatga     2700
taaccgttat caaatggatc tcgaaaacat tatcgagtgg cgttccgtct ttgaagatgg     2760
ggaaattttt gcggacaagt taactgaagt ggaatggctg acggatgagc aacgttctgc     2820
ccttgttaag aaacggtata agggctgggg acgtttatcc aagaagctac tgacgggaat     2880
cgttgacgag aacggccaac ggatcattga tctgatgtgg aatactgatc aaaacttcat     2940
gcagattgtc aaccagcctg tctttaaaga acagattgac caactgaacc aaaaggccat     3000
caccaatgat gggatgactt tgcgggagcg ggtcgagagc gttctggatg acgcctatac     3060
ttcaccgcag aacaagaagg ccatctggca agttgttcgg gtggtggaag atattgttaa     3120
agcggtcggg aatgcaccaa agtcgatttc aattgaattt gcccgtaatg aaggcaacaa     3180
gggagaaata acccggagcc ggcgtactca attgcagaaa ttatttgaag atcaggccca     3240
tgaattagtt aaggatacga gcttgactga ggaattggag aaggcaccgg atctttccga     3300
tcgttattac ttctacttca cccaaggtgg taaggatatg tacaccggtg atccaatcaa     3360
cttcgatgaa atttctacca agtatgatat tgaccacatt ttgccacaat ccttcgtgaa     3420
ggatgattcc ttagataatc gggtgttagt aagtcgggcg gagaataata agaagtctga     3480
ccgggtgcca gctaagcttt acgcagccaa gatgaaacca tactggaacc aacttttgaa     3540
gcagggattg atcacgcaac ggaagtttga aaacctgacg atggacgttg atcaaaatat     3600
taagtatcgg tcacttggat tcgtgaagcg ccaattagtt gaaacacgcc aagttatcaa     3660
gttgacggct aacatcttgg gtagtatgta ccaagaagcc gggacggaca tcattgagac     3720
tcgggctggt ttaactaagc aattacgcga ggaattcgat ttaccaaagg ttcgtgaagt     3780
aaacgactat caccacgcag ttgatgctta cctgacaacg tttgctgggc aatatttgaa     3840
ccgccgttat ccgaaattac gctccttctt cgtatacggt gagtacatga agttcaagca     3900
tgggtcagat ctgaagctac gtaactttaa cttcttccat gaattgatgg aaggcgacaa     3960
gagccaaggt aaggttgtcg atcaacaaac tggtgagctg attacgacaa gggatgaagt     4020
agccaagagc tttgatcgat tattgaacat gaagtatatg ctggtatcga aggaagttca     4080
cgaccggagt gaccaactgt atggagcaac gattgtaaca gcaaaggaat ctggtaagct     4140
cacttcacca attgagatca agaaaaatcg acctgttgat ttgtatggtg cttatacgaa     4200
tggaacgtca gctttcatga cgatcattaa gtttactgga aacaaaccta agtataaggt     4260
gattggggtt ccaacaacat cggcggtcgg tttaaaacga gttgggaaac caggcagtga     4320
atcatataac caagaattac atcgaatcat taaatctaat ccgaaggtaa agaaagattt     4380
tgagattgta gttccacatg tttcgtatag tcagttgata gttgatggtg actgcaaatt     4440
taccctagct agtgatactt atcagcatcc ggcaactcag ctagttcttt ctaaagaatc     4500
gatggaaata attgcagatg attttaaatt tgtgaaagaa aatccggcaa ctgcggatga     4560
acaacttgtt agggtttttg atgaaattgt taatcaaatg aaccattact ttactatctt     4620
tgaccaacgt agtaatcgtc aaaaggtaac gaaggctcga gataagtttg tatcgttacc     4680
aacggaatca gagtatgagg gtgctaagaa aacgcaagta gggaagacag aagtcattac     4740
gaacttactg atgggtctac atgccaatgc tgcacaaggt gatttgaaag tattaggatt     4800
atcaaccttt gggtttttcc agagttcagg tggactgaat ttaagtgaag atgcaatgat     4860
cgtataccag tcaccaaccg gtttgtttga acgtcgcatt tgtttgaaag acatttaaga     4920
gtaaagtaaa aaggagccga ttaaatcgac tcctttttat tatatgtatg gccagaataa     4980
catggctcaa aagtaataac tcgtggaaaa ccactcgttt gatcttgact atgagtgtta     5040
gatcagtagt ctcgaatgtc gggagctacc cgacaagtta tattatatgg aattcggttg     5100
aatttgacaa ggaggaattt taaaaatggg atggcgttca ataatcattg gtcaacatgc     5160
aaagattacc cactctgctc atatgatggt tgtgcagact aaagatggga ttaatgaaat     5220
tccgatggat gacattgcaa aagtactagt tgaaacaact caggcgatga tctcttcaga     5280
tttcatgagt gcatgcctac aacggaacat taaagtaatc tttgtcgatc gaaagtacca     5340
accgattggg gagacggttg gttatcagcc agtagcgagg gattatgaat tgttggaacg     5400
ccaattctta tggcccttgg agcgaaggga acaactttgg actaggattg cccacgccaa     5460
aatcgagagc caaataaagg tggcccggct taatggatgc ccggttcaag aactagaaag     5520
tgagttagaa gccattgaag taaatgatat ttctaaccgt gaggctgtgg ttgctcgaaa     5580
gtatttccca ttgctgttcg gaaaagattt tagccgccga caggagaatc aatacaacgc     5640
cgctctggat tatggatatg cggttttatt agcggagaca aaccaatcga ttacggaaaa     5700
tggctatctg atggaactag gaatccatca tcaaaatcga gaaaacaggt ttaatttggg     5760
ttcagatttg atggaaccat ttcgaccagt gatcgactac tgggttacag gacagaaatt     5820
tgcggaattc aatcgtcaag tccgagttgg cttagtagat gcaatgcata cggtgatcaa     5880
gtataacggg attgaaatgc tgactcaaaa tgcagtgagg cagtatgtgc gggaatgtct     5940
tgattacttg agtggtgagc gggatgaaat tgaagtaaag gtggagttta aagatgaggt     6000
accgaatcat gcgcttgatg gtcatgtttg atttgcccac ggacactagt cagcaacgaa     6060
agcagtatcg tcagttccgc aagaagctat taaatgaagg atttattatg atccagtact     6120
ctgtttacgt tcgtgtatgt acgacaagga gtgcggctga gtttttggag agaaggctta     6180
agaattattt accagaccaa ggagtcatcc aatcgttaat gttaacggaa aagcaataca     6240
gtgacatgca tttcttgctt ggtgatgagg ttaaagaagt tagaaattca tcaaagagga     6300
cgattgtact atgaaattgc aataccatgg ccatcaacca gttgaactga tgcctggaaa     6360
agtagtgatt ttgcaaatag agaacccaag cgtcaacacc gaattaattc aggggttgca     6420
gggatataat gattgcttaa ggatgattga cgatgagtac caagagctta atttgagtaa     6480
ggtaatgaag tgggaaggag accttgttct taatccaacc aagcttgata gctaccaaac     6540
agcacttgat aagatgattg tcaaaaatct tagcattcag aaacgagatc ggatgaatga     6600
ccttgctcgt gaggtgttct cagagatgca agattctttg ttcgaattcg acttaccgtt     6660
ggaggtgcgg tatgacgaga gcctcttgag attatacaaa tatgcgaaaa ttaaatattt     6720
gacgcaagta ataaggcaac cttatggtat aattgaaacc gatctaaaat tacatctcga     6780
attaaaagac tgtcaggttc ttgggtattg taatgtcgct aattacttat tgcctgagca     6840
gatacaggaa ttcgctactc ttgttgagaa aaccgaattg gcagttttat tagtggaatt     6900
ctcagaaaag agagaaactc tacaacaact caaacaggat atttaccgga ttgatcggga     6960
cttcgtggac tggcacgaat agatcgttag tttttgatga gaaaataacg gtcttggatg     7020
agtgtcagat cagtagttcc gagtacatcg attacaggtc aacagagttc cgatgagtct     7080
tggatgagtg tcagatcagt agttccgagt acagctaacg tccaccgagt gggcactgtt     7140
ttgtcttgga tgagtgtcag atcagtagtt ccgagtaccg gtactgccca gctgtcagcg     7200
taggttgggt cttggatgag tgtcagatca gtagttccga gtaccgattg taccgaaata     7260
cgacctttgc atttgtcttg gatgagtgtc agatcagtag ttccgagtac tgatctttta     7320
aaaatttgat ggtttctttc gtcttggatg agtgtcagat cagtagttcc gagtacgtga     7380
ccgttaagga tcagccgtcc acgcttgtct tggatgagtg tcagatcagt agttccgagt     7440
acttgctacc agtcttagcc acgccggtgg aggtcttgga tgagtgtcag atcagtagtt     7500
ccgagtacgt gacggttggc ccagagggat tgacaacggt cttggatgag tgtcagatca     7560
gtagttccga gtacaggttt ttagtggaaa actgtactta tcgcgtcttg gatgagtgtc     7620
agatcagtag ttccgagtac tgtttgcttt taactggcca acttggtcgc gtcttggatg     7680
agtgtcagat cagtagttcc gagtacacta agctagcgat tttccacagt gcattggtct     7740
tggatgagtg tcagatcagt agttccgagt acatttcaaa gagtctcagc gcctctgata     7800
cggtcttgga tgagtgtcag atcagtagtt ccgagtaccg attgatagcg tgagttgtcg     7860
gtcccgtagt cttggatgag tgtcagatca gtagttccga gtaccacaat tggttaatgc     7920
aactcacacg atccgtcttg gatgagtgtc agatcagtag tcttataatt atagactaag     7980
ggcgttgctg tttttagcaa tgcctttttt agaagtgatg ggggaaagat aaatattccc     8040
acgttggtaa tctgacggga actttagcgg gcgatgtgct aggatagggc caaaatgatt     8100
ggaagtgttt accatgcaaa ttgatcccga acggattcgc cccgaactgc accggatcgg     8160
caaggtgggg tacgcgatca acctgatggc cagcccgcac gcctgcaacg aatgggacga     8220
a                                                                     8221

<210>  6
<211>  8221
<212>  DNA
<213>  Enterococcus faecalis

<400>  6
taaaaataaa ccagtaacgc taataactcc tataaaataa aaaaactttt tcaaaatatt       60
ccctccaatt aaatttatgt attaatttta tcattagtga tagtaaacat aaagaaataa      120
aaaattcaaa gtatcaataa acattgctga tactctgaat tatagctctg cccagacttt      180
tttagttgtg gaaaagttgt gattttttat ttttttattc cataaacctt atgatttgaa      240
gggattaaaa ggtttgctat ttatcgttta gcgaagtaaa gtaaaaaagc tgttttcgat      300
tttcgaaaac agcttttttt tgcaattttt gccttttaaa aacccaaaat cagaaccgtc      360
aatttactga aaatttcttg caaatcaaag gatcccacga tacgataaat aggagaaaag      420
gcaatgagtg aaacacttat tgttaactat ttaatcaaag gacgtgtgaa gatgaacgta      480
gaagaattag ttcaaaaagc aaaagattta attggagaag gcaacgtgga acatgcgcaa      540
caattcattg aagaacataa agatgaatta ggcgaacact atcataaaat tacagcgatg      600
ttagctgata caacgaccga tggtttgttt gataaaatta aaggattgtt tcaatagtcg      660
taattaaaaa ggcaaaacac agttaaccac gcactgtgtt ttgccttttt tgccatgtaa      720
agtttgacaa catcaacaaa tagtaaaaga tattaccata caataaatat agattcgtta      780
ttttaagaaa agtaaaggaa ttaaggtaag agattcttaa atagataatg ttatttttgt      840
tatgtatata attctattag tttacaaaaa ctataaataa cccttttttt aagaaaataa      900
gaatggtaaa ctttaagtag cggtattcag tttgattaat ttggaagcga ttactttctg      960
gctgcaaaca aaaaaaagcg ccgaaacagc gccactttac agttgattac ggttaaaacc     1020
ttattttaac ttgctatgtt gtttagaata gtcccaaaag aacttaacta aattatagca     1080
tagaataaaa atcattcaag tagtaattaa aaaaaaggag tggaaataaa atgaagaaag     1140
actacgttat cggtttggat atagggacta attctgtcgg ttgggcagtt atgacagaag     1200
actatcagtt ggtgaagaaa aaaatgccta tttatggaaa cactgaaaaa aagaaaatca     1260
agaaaaattt ttggggtgtg cgtttatttg aagaagggca tacagccgaa gatcgccgat     1320
taaaaagaac agcacgacga agaattagtc gtcgacggaa tcgtttacgc tacttacaag     1380
ctttttttga agaagcgatg acagctttgg atgaaaactt ttttgctcgt ttacaagaga     1440
gttttttagt gcctgaagat aagaagtggc acagacatcc gatttttgct aagttggaag     1500
atgaagtagc ttaccatgaa acgtatccga caatctacca tttacgcaaa aaattagcag     1560
attcatctga gcaagcagat ttacgactaa tttatttggc gttggcatat attgtcaaat     1620
atcgtggaca ttttttaatt gaagggaaat taagtacaga aaatatttct gttaaagaaa     1680
aatttcaaca atttatgatc atttataacc agacctttgt gaatggagag ggtcgcttag     1740
ttagtgcgcc attacctgaa tctgtcttga ttgaggaaga gttgactgaa aaagcttctc     1800
ggactaaaaa atctgaaaaa gtcttacaac aatttcctca agaaaaagct aatggcttat     1860
ttggtcagtt cttaaagcta atggtaggga ataaggctga ctttaaaaaa gtttttggtt     1920
tggaagaaga agccaaaata acctacgcta gtgaaagcta tgaagaagat ttagaaggca     1980
ttttagcaaa ggttggggat gaatatagtg acgtgttttt agctgctaaa aatgtgtacg     2040
atgcagttga attatcaacg attttagcag attcggataa aaaaagttac gcgaaattat     2100
cttctagcat gattgtccgt tttacagaac atcaagaaga tttaaaaaaa ttcaaacgat     2160
ttattcgtga aaattgtcca gacgaatatg ataatctctt taaaaatgaa cagaaagacg     2220
gctatgcagg ctacattgca cacgcaggta aggtttcaca gcttaaattt taccagtatg     2280
ttaagaaaat cattcaagat attgctggag cagaatattt tttagaaaaa attgctcaag     2340
aaaacttttt aagaaagcaa cggacctttg ataatggggt gattcctcat caaattcatt     2400
tggctgagtt acaagcaatc attcatcgtc aagcggccta ttatccattt ttaaaagaaa     2460
atcaagaaaa aattgaacaa ctggttacat ttcgaattcc ttattatgtc ggaccattat     2520
caaaaggaga tgcaagtacc ttcgcttggc taaaacgtca aagtgaggaa ccaattcgac     2580
cttggaacct tcaagaaacc gttgatttgg accaatcagc gacagccttt attgaacgaa     2640
tgaccaattt tgatacgtat ttaccttctg aaaaagtttt accgaaacat agtttgttat     2700
atgaaaagtt tatggtattt aatgaattga ccaagatttc ttatacggat gatcgaggca     2760
tcaaagccaa tttttcaggt aaggaaaaag aaaaaatctt tgattatctg tttaagacgc     2820
gtcgcaaagt taagaaaaag gatatcattc aattctatcg aaacgaatat aatacggaga     2880
ttgtcacgct tagtggactt gaagaagacc aatttaatgc tagttttagc acgtatcagg     2940
atttactgaa atgtggtttg acacgagcag aattagacca cccagataat gccgaaaaat     3000
tggaagatat cataaaaatt ttaactattt ttgaagatcg gcaacgaatt cggacgcaac     3060
tttctacatt caaagggcag ttctcagcag aagtactaaa aaaattagaa cgcaagcact     3120
acactggctg gggaagattg tcgaagaaat taatcaatgg tatctacgat aaagaatcgg     3180
gtaaaacaat tttggactat ttagttaaag atgatggggt ctcaaaacac tataatcgca     3240
attttatgca actgattaat gattcacaat tatcttttaa aaatgctatt caaaaagcac     3300
agtccagtga acatgaagaa acattaagtg aaactgtcaa tgaattagct ggtagcccag     3360
caataaaaaa aggaatttat caaagtttaa aaattgtcga tgaactagtc gcgattatgg     3420
gttatgcgcc taagcggatt gttgtcgaaa tggcacgtga aaatcaaacg actagcactg     3480
gcaagagaag atccatccaa cgcttgaaaa tagttgaaaa agcaatggcc gaaatcggca     3540
gcaatttatt aaaagaacaa ccaacgacta atgaacagtt acgagatacc cgtcttttcc     3600
tttactatat gcaaaatggt aaagatatgt acacgggaga tgaattatcg cttcatcgtt     3660
tatctcacta tgatattgat catattatcc cacaaagttt tatgaaagac gattcattgg     3720
ataacctagt tttagtgggc tctactgaaa atcgagggaa atccgatgat gtacctagca     3780
aggaagttgt taaggatatg aaagcttatt gggagaaatt atatgctgct ggcttaatta     3840
gtcaacggaa attccaacgt ctgaccaaag gggagcaagg tggcttgact ctcgaagaca     3900
aagcgcattt tatccaacga caattagtag aaactcgtca aattaccaaa aatgttgcag     3960
ggatcttaga tcaacgctac aatgccaagt caaaagagaa aaaagtccaa atcatcacct     4020
tgaaagctag tttaacgagc caatttcgtt cgatttttgg cttgtataaa gttcgtgaag     4080
tgaatgatta tcaccatgga caagatgctt atttaaactg tgtggtcgca accacgttat     4140
taaaagttta tcctaattta gcaccagaat ttgtttacgg agaatatcct aagttccaga     4200
cctttaaaga aaataaagcc acggcgaagg ctataattta tacaaatttg ctgcgctttt     4260
tcacggaaga tgaaccacgg ttcacgaagg atggcgaaat tctttggagt aacagttatt     4320
taaaaactat caaaaaagaa ttaaattacc atcaaatgaa tattgtcaaa aaagtagaag     4380
tgcaaaaagg cggtttttca aaagagtcga ttaaacccaa aggaccatcg aataaattga     4440
ttcctgtcaa aaatggtttg gatccccaaa aatatggcgg ttttgatagt cctatagttg     4500
catatacagt gctattcacg catgaaaaag gtaaaaaacc tcttattaaa caggagatac     4560
tgggcattac gattatggaa aaaacaaggt ttgaacaaaa tcctattctt tttttagagg     4620
agaaaggctt cctacggcct cgtgtattaa tgaaattgcc taagtataca ctgtatgaat     4680
ttccagaggg acgccggcgc ttattagcca gcgctaaaga agcgcaaaaa gggaaccaga     4740
tggttttacc tgaacattta cttacattac tgtaccatgc gaaacaatgt ttgttaccaa     4800
atcaatcaga aagtttggct tatgtagaac aacatcaacc agaatttcaa gagattttag     4860
agagagtggt tgactttgct gaagtgcata cattagccaa gtcaaaagtc cagcaaattg     4920
tgaaactttt tgaagcaaat caaacagcag atgtgaaaga gattgcggca tcctttatcc     4980
aacttatgca gtttaatgcg atgggcgcac caagtacgtt taaatttttc caaaaagaca     5040
ttgagcgagc acgctacacg tcaatcaaag aaatttttga tgccactatc atttaccaat     5100
cgactacggg actgtatgaa acacgcagaa aggttgtcga ctagatgggc tggcgaacgg     5160
tagtggttaa caagcattca aaattatcct ataaaaacaa tcatcttgtt tttaaagcaa     5220
ttgatcacca agaattaatt catttgtctg agattgatgt tttgttgttg gaaacaacgg     5280
acatttcgtt aaccacgatg ctattaaaac gattaattga tgaaaaaata ttagtgttat     5340
tttgcgatga taagcgtttg ccaattggta aaattttgcc cttttatgga cggcatgata     5400
gtagcttgca attgacacgc cagttggctt ggacggaaga acgaaaaggt caagtttgga     5460
cagcgatcat tgcacaaaaa atcaccaatc agagtttaca cttagcgcaa cgagactata     5520
gccaaaaggc tgctgctttg ttagctatgc gcgctgaatt acgtctgttt gatccagcca     5580
atcgagaagg tcatgcagct cgaagttact ttaatactct cttcggcaat gattttacac     5640
gtgaacaaga aaatgacatt aatgctggtt taaactatgg ttatacgttg ttattaagta     5700
tttttgctcg agagttagtc cagacaggtt gttttacaca actaggacta aaacatgcca     5760
accaatttaa tgactttaac ttagcaagtg atcttatgga gccttttcgt ccattggtag     5820
atcaaatcat ttatgagaat agaaaagaag catttccgat aatgaaacgt aagttatttg     5880
ctttgtttat gaatacgtat atgtacaaga aaaaacaaat gtttttaacc aatattgcta     5940
ccgattatac aaaacatgta gtaaaagttc tgaatcaaga ggaggaagga gttccagagt     6000
ttgggatatg agttatcgat atatgcgtct attattaatg tttgatatgc caacggacac     6060
agccagtgac cggaaagcgt atcggaagtt ccggaaattt ttgattaatg aaggatttat     6120
tatgcatcaa ttttcggttt acagcaaaat tttgttgaat gatactgcta ataaagcaat     6180
gttggctcgc ttaaagcaga ataatccgca aagaggacta attacactat taaatgtaac     6240
agaaaaacaa ttttctcgaa tgatttattt gcatggagaa caagacaatc gagttgctaa     6300
ttcagatgaa cggattgtct ttttaggaga agaatagatg agagttaatt tttctttatt     6360
ggaagaaccc attgaaattg aaaaagccac ctttttaacg attaaagacg ttcaaacctt     6420
tgcccatcta gtgaagttaa tttatcaata tgatggggaa aatgagttaa aactatttga     6480
tgcgcaacaa aaagggctga aaccaacgga attatttgtt gttacggata ttttaggcta     6540
tgacgttaat tcggctgcca cgctgaaatt aatctatggg gatttagaag cacaattaaa     6600
tgataaacca gaagtcaaat caatgattga gaagttaact ggaacaatta gtcaattaat     6660
tggctatgaa ttgttggaac atgaaatgga tttggaagaa gatggcatca ctgtgcagga     6720
acttttcaaa gctcttggaa tcaaaatcga aacaacgagt gatacgattt ttgaaaaagt     6780
tatggaaatt acacaagtac atcgttattt atcaaagaaa aaattattga tttttattaa     6840
tgcgtgtacg tatttgacag aggatgaagt gcaacaagtg gtagaatata tctctttaaa     6900
taatgtggat gtcctgtttt tagaacaaag ggtggtccag aacagattcc aatatatttt     6960
ggacgaaaac ttttatttga gttatgaaaa agcttaaatt gttactgatt agtggttcat     7020
tctaaactga aatctagcta tggataagtg atgcgagtac ggaactttgg aaaaaaataa     7080
ttctccgagg ttttagagtc atgttgttta gaatggtacc aaaacaagtg caactagcta     7140
gaattgaatc aaactgtttt agagtcatgt tgtttagaat ggtaccaaaa cccacctgtt     7200
gcatatatag cattcacaag tgttttagag tcatgttgtt tagaatggta ccaaaacatt     7260
taagattaga tatgaacaac ttacgttgtt ttagagtcat gttgtttaga atggtaccaa     7320
aactcaatcc attcagcaac tatattgtgt ttagttttag agtcatgttg tttagaatgg     7380
taccaaaaca tgtactcatt ctaatgtata agaagtgcag ttttagagtc atgttgttta     7440
gaatggtacc aaaacgtgaa cttttttctg ttggtgcgtt gtttcgtttt agagtcatgt     7500
tgtttagaat ggtaccaaaa ctaaacagtc taccatgtaa ctagtgaatg cgttttagag     7560
tcatgttgtt tagaatggta ccaaaactta tagaagtaca gtcaccatca gcgacctgtt     7620
ttagagtcat gttgtttaga atggtaccaa aacagggctg caggagttaa tgttacaatc     7680
tcagttttag agtcatgttg tttagaatgg taccaaaaca tcatctcatc gactaaatat     7740
gctttgtatg ttttagagtc atgttgttta gaatggtacc aaaacccact ttattaattg     7800
cttgtcaaca cgtctgtttt agagtcatgt tgtttagaat ggtaccaaaa cgtatctacg     7860
tgcataatca tatcgactca tgttttagag tcatgttgtt tagaatggta ccaaaaccaa     7920
tgtaaatgct cattatgatt tacatatgtt ttagagtcat gttgtttagt tttcgcagat     7980
acgatttgat tgatgtaaaa atatcgttaa tatgtataaa tatggttatt atataaaaaa     8040
tataagtaat aaattgaagc tttgctaaag caagtgatgc gattacgaaa ttatttaatt     8100
ttagagtcac gttatttatt actttacgaa tagagaatac gattatctat aaatcaagaa     8160
ttaatcccca atttattgaa aatgacactc cctgttttat taatatttca tgcttttgtt     8220
g                                                                     8221

<210>  7
<211>  8221
<212>  DNA
<213>  Bacillus cereus

<220>
<221>  misc_feature
<222>  (7114)..(7123)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (7176)..(7289)
<223>  n is a, c, g, or t

<400>  7
agtttacgaa gaccatacag gcgaaaaagg ccaagaacaa atcattggtg gcggtactta       60
tggccgctta ttaaaacgtg gtgttgccta tggcgcaatg ttccctggct acacagacac      120
aatgcaccaa gccaacgaat ttatggaatt agatgactta ttccgagcag ctgctattta      180
tgcagatgcg atttatcgtt tagcgaagta aagtaaaaaa gctgttttcg attttcgaaa      240
acagtttttt tttgcaattt ttgcctttta aaaacccaaa atcagaaccg tcaatttact      300
gaaaatttct tgcaaatcaa aggatcccac gatacgataa ataggagaaa acgcaatgag      360
tgaaacactt attgttaact atttaatcaa aggacgtgtg aagatgaacg tagaagaatt      420
agttcaaaaa gcaaaagatt taattggaga aggcaacgtg gaacatgcgc aacaattcat      480
tgaagaacat aaagatgaat taggcgaaca ctatcataaa attacagcgc tgttagctga      540
tacaacgacc gatggtttgt ttgataaaat taaaggatta tttcaatagt cgtaattaaa      600
aaggcaaaac acagttaacc acgcactgtg ttttgccttt tttgccatgt aaagtttgac      660
aacatcaaca aatagtaaaa gatattacca tacaataaat atagattcgt tattttaagg      720
aaagtaaaga aattaaggta agagattctt aaatagataa tgttattttt gttacatata      780
taactatatt agttaaaaaa actataaata accctttttt taagaaaata agaatggtaa      840
actttaagta gtgttattca gtttgattga tttggaagcg attactttta aatttcaaac      900
aaaaaaagcg ccgaaacagc gccactttac agttgattac ggttaaaacc ttattttaac      960
ttgctatgtt gtttagaata gtcccaaaag aacttaacta aattatagca tagaataaaa     1020
atcattcaag tagtaattta aaaaaaggag tggaaataaa atgaagaaag attacgttat     1080
tggtctggat ataggaacta attctgtcgg ctgggcagtt atgacagaag actatcagtt     1140
ggtgaagaaa aaaatgccta tttatggaaa cactgaaaaa aagaaaatta agaaaaattt     1200
ttggggtgtg cgtttatttg aagaagggca tacagccgaa gatcgccgat taaaaagaac     1260
agcacgacga agaattagtc gtcgacggaa tcgtttacgc tacttacaag ctttttttga     1320
agaagcgatg acagatttgg atgaaaactt ttttgctcgt ttacatgaga gttttttagt     1380
gcctgaagat aagaagtggc acagacatcc gatttttgct aagttggaag atgaagtagc     1440
ttaccatgaa acgtatccga caatctacca tttacgcaaa aaattagcag attcatctga     1500
gcaagcagat ttacgactaa tttatttggc gttggcccat attgtcaaat atcgtggaca     1560
ttttttaatt gaaggaaaac taagtacaga aaatacttct gttaaagaac aatttcaaca     1620
atttatggtc atttataacc aaacctttgt gaatggggag agtcgcttag ttagtgcgcc     1680
tttacctgaa tctgtcttga ttgaggaaga gttaactgaa aaagcttctc ggactaaaaa     1740
atctgaaaaa gtcttacaac aatttcctca agaaaaagct aatggcttat ttggtcagtt     1800
tttaaagcta atggtaggga ataaagctga ctttaaaaaa gtttttgctt tggaagaaga     1860
agccaaaata acctacgcta gtgaaagtta tgaagaagat ttagaaggca ttttagcaaa     1920
gattggggat gaatatagtg acgtgttttt agctgctaaa aatgtgtacg atgcagttga     1980
attatcaacg attttagcag attcggataa aaaaagtcac gcgaaattat cttctagcat     2040
gattgtccgt tttacagaac atcaagaaga tttaaaaaaa ttcaaacggt ttattcgtga     2100
aaattgtcca gacgaatatg ataatctctt taaaaatgaa cagaaagacg gctatgcagg     2160
ttacattgca cacgcaggta aggtttcaca gcttaaattt taccagtatg ttaagaaaat     2220
cattcaagat attgctggag cagaatattt tttagaaaaa attgctcaag aaaacttttt     2280
aagaaagcaa cggacctttg ataatggggt gattcctcat caaattcatt tggctgagtt     2340
acaagcaatc attcatcgtc aagcggccta ttatccattt ttaaaagaaa atcaagaaaa     2400
aattgaacaa ctggttacat ttcgaattcc ttattatgtc ggaccattat caaaaggaga     2460
tgcaagtacc ttcgcttggt taaaacgtca aaatgagaaa ccaattcgac cttggaacct     2520
tcaagaaacc gttgatttgg accaatcagc gacagccttt attgaacgaa tgaccaattt     2580
tgatacgtat ttaccttctg aaaaagtttt accgaaacat agtttgttat atgaaaagtt     2640
tatggtattt aatgaattga ccaagatttc ttatacggat gatcgaggaa tcaaagccaa     2700
tttttcaggt aaggaaaaag aaaaaatctt tgattatctg tttaagacgc gtcgaaaagt     2760
taagaaaaag gatataattc aattctatcg aaacgaatat aatacggaga ttgtcacgct     2820
tagtggactt gaagaagacc aatttaatgc tagttttagc acgtatcagg atttactgaa     2880
atgtggtttg acaagagcag aattagacca cccagataat gccgaaaaat tggaagatat     2940
cataaaaatt ttaactattt ttgaagatcg gcaacgaatt cggacgcaac tttccacatt     3000
caaagggcag ttctcagcag aagtactaaa aaaattagaa cgcaagcact acactggctg     3060
gggaagattg tcgaagaaat taatcaatgg tatctacgat aaagaatcgg gtaaaacaat     3120
tttggactat ttagttaaag atgatggggt ctcaaaacac tataatcgca attttatgca     3180
actgattaat gattcacaat tatcttttaa aaatgcgatt caaaaagcac agtccagtga     3240
acatgaagaa acattaagtg aaactgtcaa tgaattagct ggtagcccag caataaaaaa     3300
aggaatttat caaagtttaa aaattgtcga tgaactagtc gcgattatgg gttatgcgcc     3360
taagcggatt gttgtcgaaa tggcacgtga aaatcaaacg actagcactg gcaagagaag     3420
atccatccaa cgcttgaaaa tagttgaaaa agcaatggcc gaaatcggca gcaatttatt     3480
aaaagaacaa ccaacgacta atgaacagtt acgagatacc cgtcttttcc tttactatat     3540
gcaaaatggt aaagatatgt acacgggaga tgaattatcg cttcatcgtt tatctcacta     3600
tgatattgat catattatcc cacaaagttt tatgaaagac gattcattgg ataacctagt     3660
tttagtgggc tctactgaaa atcgagggaa atccgatgat gtacctagca aggaagttgt     3720
taaggatatg aaagcttatt gggagaaatt atatgctgct ggcttaatta gtcaacggaa     3780
attccaacgt ctgaccaagg gggagcaagg tggcttgact ctcgaagaca aagcgcattt     3840
tatccaacgg caattagtag aaactcgtca aattaccaaa aatgttgcag ggatcttaga     3900
tcaacgctac aatgccaagt caaaagagaa aaaagtccaa atcatcacct tgaaagctag     3960
tttaacgagc caatttcgtt cgatttttgg cttgtataaa gtccgtgaag tgaatgatta     4020
tcaccatgga caagatgctt atttaaactg tgtggtcgca accacgttat taaaagtttg     4080
tcctaattta gcaccagaat ttgtttacgg agaatatcct aagttccaga cctttaaaga     4140
aaataaagcc acggcgaagg ctataattta tacaaatttg ctgcgctttt tcacggaaga     4200
tgaaccacgg ttcacgaagg atggcgaaat tctttggagt aacagttatt taaaaactat     4260
caaaaaagaa ttaaattacc atcaaatgaa tattgtcaaa aaagtagaag tgcaaaaagg     4320
cggtttttca aaagagtcga ttaaacccaa aggaccatcg aataaattga ttcctgtcaa     4380
aaatggtttg gatccccaaa aatatggcgg ttttgatagt cctgtagttg cttatacagt     4440
gctattcacg catgaaaaag gtaaaaaacc tcttattaaa caggagatac tgggcattac     4500
gattatggaa aaaacaaggt ttgaacaaaa tcctattctt tttttagagg agaaaggctt     4560
cctgcggcct cgtgtattaa tgaaattgcc taagtataca ctgtatgaat ttccagaggg     4620
gcgccggcgc ttattagcta gtgctaaaga agcgcaaaaa gggaaccaga tggttttacc     4680
cgaacattta cttacattac tgtaccatgc gaaacaatgt ttgttaccaa atcaatcaga     4740
aagtttggct tatgtagaac aacatcaacc agaatttcaa gagattttag agagagtggt     4800
tgactttgct gaagtgcata cattagccaa gtcaaaagtc cagcaaattg tgaaactttt     4860
tgaagcaaat caaacagcag atgtgaaaga gattgcggca tcctttatcc aacttatgca     4920
gtttaatgcg atgggcgcac caagtacgtt taaatttttc caaaaagata ttgagcgagc     4980
acgctacacg tcaatcaaag aaatttttga tgccactatc atttaccaat cgactacggg     5040
cctgtatgaa acacgcagaa aggttgtcga ctagatgggc tggcgaacgg tagtggttaa     5100
taagcattca aaattatcct ataaaaacaa tcatcttgtt tttaaagcca ttgatcacca     5160
agaattaatt catttgtctg agattgatgt tttgttgttg gaaacaacgg acatttcgtt     5220
aaccacgatg ctattaaaac gattaattga tgaaaaaata ttagtgttat tttgcgatga     5280
taagcgtttg ccaattggta aaattttgcc cttttatgga cggcatgata gtagcttgca     5340
attgacacgt cagttggctt ggacggaaga acgaaaaggt caagtttgga cagcgatcat     5400
tgcacaaaaa atcaccaatc agagtttaca cttagcgcaa cgagactatg gccaaaaggc     5460
tgctgctttg ttagctatgc gcgctgaatt acgtctgttt gatccagcca atcgagaagg     5520
tcatgcagct cgaagttatt ttaatactct cttcggcaat gattttacac gtgaacaaga     5580
aaatgacatt aatgctggtt taaactatgg ttatacgttg ttattaagta tttttgctcg     5640
agagttagtc cagacaggtt gttttacaca actaggacta aaacatgcca accaatttaa     5700
tgactttaac ttagcaagtg atcttatgga gccttttcgt ccattggtag atcaaatcat     5760
ttatgagaat agaaaagaag cctttccgat aatgaaacgt aagttatttg ctttgtttat     5820
gaatacgtat atgtacaaga aaaaacaaat gtttttaacc aatattgcta ccgattatac     5880
aaaacatgta gtaaaagttc tgaatcaaga ggaggaagga gttccagagt ttgggatatg     5940
agttatcgat atatgcgtct attattaatg tttgatatgc caacggacac agccagtgac     6000
cggaaagcgt atcggaagtt ccggaaattt ttgattaatg aaggatttat tatgcatcaa     6060
ttttcggttt acagcaaaat tttgttgaat gatactgcta ataaagcaat gttggctcgc     6120
ttaaagcaga ataatccgca aagaggacta attacactat taaatgtaac agaaaaacaa     6180
ttttctcgaa tgatttattt acatggagaa caagacaatc gagttgctaa ttcagatgaa     6240
cggattgtct ttttaggaga agaatagatg agagttaatt tttctttatt ggaagaaccc     6300
attgaaattg aaaaagccac ctttttaacg attaaagacg ttcaaacctt tgcccatcta     6360
gtgaagttaa tttatcaata tgatggggaa aatgagttaa aactatttga tacgcaacaa     6420
aaagggctga aaccaacgga attatttgtt gttacggata ttttaggcta tgatgttaat     6480
tcggctgcca cgctgaaatt aatctatggg gatttagaag cacaattaaa tgataaacca     6540
gaagtcaaat caatgattga gaagttaact ggaacaatta gtcaattaat tggctatgaa     6600
ttgttggaac atgaaatgga tttggaagaa gatggcatca ctgtgcagga acttttcaaa     6660
gctcttggaa tcaaaatcga aacaacgagt gatacgattt ttgaaaaagt tatggaaatt     6720
acacaagtac atcgttattt atcaaagaaa aaattattga tttttattaa tgcgtgtacg     6780
tatttgacag aggatgaagt gcaacaagtg gtagaatata tctctttaaa taatgtggat     6840
gtcctgtttt tagaacaaag ggtggtccag aacagattcc aatatatttt ggacgaaaac     6900
ttttatttga gttatgaaaa agcttaaatt gttattgatt agtggttcgt tctaaactga     6960
aatctagcta tggataagtg atgcgagtac ggaactttgg agaaaaaata attctccgag     7020
gttttagagt catgttgttt agaatggtac caaaactgcc ctctgcttta ttatgtgtgt     7080
gagagggttt tagagtcatg ttgtttagaa tggnnnnnnn nnntgtttgt ttgttggaat     7140
atagtcttgg tggttttaga gtcatgttgt ttagannnnn nnnnnnnnnn nnnnnnnnnn     7200
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn     7260
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnt aacaaagaaa aagcatgatt tattgattgt     7320
tttagagtca tgttgtttag aatggtacca aaacaaacaa aatatataac gaagattgct     7380
tagagtttta gagtcatgtt gtttagaatg gtaccaaaac ggatcccaca cctcaacccc     7440
aaatggtgtt gttttagagt catgttgttt agaatggtac caaaacttga gactgcgtat     7500
aattgtgagt atggtggttt tagagtcatg ttgtttagaa tggtaccaaa actgaaactt     7560
ccaaggcatc cctttactag ttgttttaga gtcatgttgt ttagaatggt accaaaactt     7620
gtttcacctc gtttctgtta ttaagtgtgt tttagagtca tgttgtttag aatggtacca     7680
aaacttgaga ctgcgtataa ttgtgagtat ggtggtttta gagtcatgtt gtttagaatg     7740
gtaccaaaac agaagttcct tacaacgtat caacttaccg gttttagagt catgttgttt     7800
agaatggtac caaaacactc tatatcgtgc attcttttcc aatgttgttt tagagtcatg     7860
ttgtttagtt ttcgcagata cgatttgatt gatgtaaaaa tatcgttaat atgtataaat     7920
gtgattgtta tataaaaaat ataagtaata aattgaagct ttgctagagc aagtgatgcg     7980
attacgaaat tatttaattt tagagtcacg ttatttatta ctttgcgaat agagaatacg     8040
attatctata aatcaagaac taatccccaa tttattgaaa atgacactcc ctgttttatt     8100
aatatttcat gcttttgttg tactatttga tgatacaaaa aagtaaaact gaggacccaa     8160
ttaaagtcaa gttaaccaca ttgaaagata aacctttcaa tgtggttaaa gatgcttaat     8220
g                                                                     8221

<210>  8
<211>  8091
<212>  DNA
<213>  Enterococcus faecalis

<400>  8
ggcgcaatgt tccctggcta cacagacaca atgcaccaag ccaacgaatt tatggaatta       60
gatgacttat tccgagcagc tgctatttat gcagatgcga tttatcgttt agcgaagtaa      120
agtaaaaaag ctgttttcga ttttcgaaaa cagctttttt tttgcaattt ttgcctttta      180
aaaacccaaa atcagaactg tcaatttact gaaaatttct tgcaaatcaa gggatcccac      240
gatacgataa ataggagaaa acgcaatgag tgaaacactt attgttaact atttaatcaa      300
aggacgtgtg aagatgaacg tagaagaatt agttcaaaaa gcaaaagatt taattggaga      360
aggcaacgtg gaacatgcgc aacaattcat tgaagaacat aaagatgaat taggcgaaca      420
ctatcataaa attacagcgc tgttagctga tacaacgacc gatggtttgt ttgataaaat      480
taaaggattg tttcaataat cgtaattaaa aaggcaaaac acagttaacc acgcactgtg      540
ttttgccttt tttgccatgt aaagtttgac aacatcaaca aatagtaaaa gatattacca      600
tacaataaat atagattcgt tattttaagg aaagtaaaga aattaaggta agagattctt      660
aaatagataa tgttattttt gttatgtata taattctatt agtttacaaa aactataaat      720
accccttttt ttaagaaaat aagaatggta aactttaagt agcggtattc agtttgatca      780
atttggaagc gattactttc tgattgtaaa caaaaaaagc gccgaaacag cgccacttta      840
cagttgatta cggttgaaac cttattttaa cttgctatgt tgtttagaat agtcccaaaa      900
gaacttaact aaattatagc atagaataaa aatcattcaa gtagtaattt aaaaaaagga      960
gtggaaataa aatgaagaaa gactacgtta tcggtttgga tatagggact aattctgtcg     1020
gttgggcagt tatgacagaa gactatcagt tggtgaagaa aaaaatgcct atttatggaa     1080
acactgaaaa aaagaaaatc aagaaaaatt tttggggtgt gcgtttattt gaagaagggc     1140
atacagctga agatcgccga ttaaaaagaa cagcacgacg aagaattagt cgtcgacgga     1200
atcgtttacg ctacttacaa gctttttttg aagaagcgat gacagatttg gatgaaaact     1260
tttttgctcg tttacaagag agttttttag tgcctgaaga taagaagtgg cacagacatc     1320
cgatttttgc taagttggaa gatgaagtag cttaccatga aacgtatccg acaatctacc     1380
atttacgcaa aaaattagca gattcatctg agcaagcaga tttacgacta atttatttgg     1440
cgttggccca tattgtcaaa tatcgtggac attttttaat tgaaggaaaa ctaagtacag     1500
aaaatacttc tgttaaagaa caatttcaac aatttatggt catttataac caaacctttg     1560
tgaatggaga gagtcgctta gttagtgcgc cattacctga atctgtcttg attgaggaag     1620
agttaactga aaaagcttct cggactaaaa aatctgaaaa agtcttacaa caatttcctc     1680
aagaaaaagc taatggctta tttggtcagt tcttaaagct aatggtaggg aataaagctg     1740
actttaaaaa agtttttggt ttggaagaag aagccaaaat aacctacgct agtgaaagct     1800
atgaagaaga tttagaaggc attttagcaa aggttgggga tgagtatagt gacgtgtttt     1860
tagctgctaa aaatgtgtac gatgcagttg aattatcaac gattttagca gattcggata     1920
aaaaaagtca cgcgaaatta tcttctagca tgattgtccg ttttacagaa caccaagaag     1980
atttaaaaaa attcaaacga tttattcgtg aaaattgtcc agacgaatat gataatctct     2040
ttaaaaatga acagaaagac ggttatgcag gctacattgc gcacgcaggt aaggtttcac     2100
agcttaaatt ttaccagtat gttaagaaaa tcattcaaga tattgctgga gcagaatatt     2160
ttttagaaaa aattgctcaa gaaaactttt taagaaagca acggaccttt gataatgggg     2220
tgattcctca tcaaattcat ttggctgagt tacaagcaat cattcatcgt caagcggcct     2280
attatccatt tttaaaagaa aatcaagaaa aaattgaaca actggttaca tttcgaattc     2340
cttattatgt cggaccatta tcaaaaggag atgcaagtac cttcgcttgg ttaaaacgtc     2400
aaagtgagga accaattcga ccttggaacc ttcaagaaac cgttgatttg gaccaatcag     2460
cgacagcctt tattgaacga atgaccaatt ttgatacgta tttaccttct gaaaaagttt     2520
taccgaaaca tagtttgtta tatgaaaagt ttatggtatt taatgaattg accaagattt     2580
cttatacgga tgatcgagga atcaaagcca atttttcagg taaggaaaaa gaaaaaatct     2640
ttgattatct gtttaagacg cgtcgaaaag ttaagaaaaa ggatataatt caattctatc     2700
gaaacgaata taatacggag attgtcacgc ttagtggact tgaagaagac caatttaatg     2760
ctagttttag cacgtatcag gatttactga aatgtggttt gacaagagca gaattagacc     2820
acccagataa tgccgaaaaa ttggaagata tcataaaaat tttaactatt tttgaagatc     2880
ggcaacgaat tcggacgcaa ctttccacat tcaaagggca gttctcagca gaagtactaa     2940
aaaaattaga acgcaagcac tacactggct ggggaagatt gtcgaagaaa ttaatcaatg     3000
gtatctacga taaagaatcg ggtaaaacaa ttttggacta tttagttaaa gatgatgggg     3060
tctcaaaaca ctataatcgc aattttatgc aactgattaa tgattcacaa ttatctttta     3120
aaaatgctat tcaaaaagca cagtccagtg aacatgaaga aacattaagt gaaactgtca     3180
atgaattagc tggtagccca gcaataaaaa aaggaattta tcaaagttta aaaattgtcg     3240
atgaactagt cgcgattatg ggttatgcgc ctaagcggat tgttgtcgaa atggcacgtg     3300
aaaatcaaac gactagcact ggcaaaagaa gatccatcca acgcttgaaa atagttgaaa     3360
aagcaatggc cgaaatcggc agcaatttat taaaagaaca accaacgacc aatgaacagt     3420
tacgagatac ccgtcttttc ctttactata tgcaaaatgg taaagatatg tacacgggag     3480
atgaattatc gcttcatcgt ttatctcact atgatattga tcatattatc ccacaaagtt     3540
ttatgaaaga cgattcattg gataacctag ttttagtggg ctctactgaa aatcgaggga     3600
aatctgatga cgtcccaagt aagaaagttg ttaagaagat gaaagcttat tgggagaaat     3660
tatatgctgc tggcttaatt agtcaacgga aattccaacg tctgaccaag ggggagcaag     3720
gtggcttgac tctcgaagac aaagcgcatt ttatccaacg gcaattagta gaaactcgtc     3780
aaattaccaa aaatgttgca gggatcttag atcaacgcta caatgccaag tcaaaagaga     3840
aaaaagtcca aatcatcacc ttgaaagcta gtttaacgag ccaatttcgt tcgatttttg     3900
gcttgtataa agtccgtgaa gtgaatgatt atcaccatgg acaagatgct tatttaaact     3960
gtgtggtcgc aaccacgtta ttaaaagttt accctaattt agcaccagaa tttgtttacg     4020
gagaatatcc taaattccag gcctttaaag aaaataaagc cacggcgaag actataattt     4080
atacaaattt gatgcgcttt ttcacggaag atgaaccacg gttcacgaag gatagcgaaa     4140
ttctttggag taacagttat ttgaaaacta tcaaaaaaga attaaattac catcaaatga     4200
atattgtcaa aaaagtagaa gtgcaaaaag gcggtttttc aaaagagtcg attaaaccca     4260
aaggaccatc gaataaattg attcctgtca aaaatggttt ggatccccaa aaatatggcg     4320
gttttgatag tcctgtagtt gcttatacag tgctattcac gcatgaaaaa ggtaaaaaac     4380
ctcttattaa acaggagata ctgggcatta cgattatgga aaaaacaagg tttgaacaaa     4440
atcctattct ttttttagag gagaaaggct tcctgcggcc tcgtgtatta atgaaattgc     4500
ctaagtatac actgtatgaa tttccagagg ggcgccggcg cttattagct agtgctaaag     4560
aagcgcaaaa agggaaccag atggttttac ctgaacattt acttacatta ctgtaccatg     4620
cgaaacaatg tttattacca aatcaatcag aaagtttggc ttatgtagaa caacatcaac     4680
cagaatttca agagatttta gagagagtgg ttgactttgc tgaagtgcat acattagcca     4740
agtcaaaagt ccagcaaatt gtgaaacttt ttgaagcaaa tcaaacagca gatgtgaaag     4800
agattgcggc atcctttatc caacttatgc agtttaatgc gatgggcgca ccaagtacgt     4860
ttaaattttt ccaaaaagat attgagcgag cacgctacac gtcaatcaaa gaaatttttg     4920
atgccactat catttaccaa tcgactacgg gcctgtatga aacacgcaga aaggttgtcg     4980
actagatggg ctggcgaacg gtagtggtta ataagcattc aaaattatcc tataaaaaca     5040
atcatcttgt ttttaaagcc attgatcacc aagaattaat tcatttgtct gagattgatg     5100
ttttgttgtt ggaaacaacg gacatttcgt taaccacgat gctattaaaa cgattaattg     5160
atgaaaaaat attagtgtta ttttgcgatg ataagcgttt gccaattggt aaaattttgc     5220
ccttttatgg acggcatgat agtagcttgc aattgacacg tcagttggct tggacggaag     5280
aacgaaaagg tcaagtttgg acagcgatca ttgcacaaaa aatcaccaat cagagtttac     5340
acttagcgca acgagactat ggccaaaagg ctgctgcttt gttagctatg cgcgctgaat     5400
tacgtctgtt tgatccagcc aatcgagaag gtcatgcagc tcgaagttat tttaatactc     5460
tctttggcaa tgattttaca cgtgaacaag aaaatgacat taatgctggt ttaaattatg     5520
gttatacgtt gttattaagt atttttgctc gagagttagt ccagacaggt tgttttacac     5580
aactaggact aaaacatgcc aaccaattta atgactttaa cttagcaagt gatcttatgg     5640
agccttttcg tccattggta gatcaaatca tttatgagaa tagaaaagaa gcatttccga     5700
taatgaaacg taagttattt gctttgttta tgaatacgta tatgtacaag aaaaaacaaa     5760
tgtttttaac caatattgct accgattata caaaacatgt agtaaaagtt ctgaatcaag     5820
aggaggaagg agttccagag tttgggatat gagttatcga tatatgcgtc tattattaat     5880
gtttgatatg ccaacggaca cagccagtga ccggaaagcg tatcggaagt tccggaaatt     5940
tttgattaat gaaggattta ttatgcatca attttcggtt tacagcaaaa ttttgttgaa     6000
tgatactgct aataaagcaa tgttggctcg cttaaagcag aataatccgc aaagaggact     6060
aattacacta ttaaatgtaa cagaaaaaca attttctcga atgatttatt tgcatggaga     6120
acaagacaat cgagttgcta attcagatga acggattgtc tttttaggag aagaatagat     6180
gagagttaat ttttctttat tggaagaacc cattgaaatt gaaaaagcca cctttttaac     6240
gattaaagac gttcaaacct ttgcccatct agtgaagtta atttatcaat atgatgggga     6300
aaatgagttg aaactatttg atgcgcaaca aaaagggctg aaaccaacag aattatttgt     6360
tgttacggat attttaggct atgacgttaa ttcggctgcc acgctgaaat taatctatgg     6420
ggatttagaa gcacaattaa atgataaacc agaagtcaaa tcaatgattg agaagttaac     6480
tggaacaatt agtcaattaa ttggctatga attgttggaa catgaaatgg atttggaaga     6540
agatggcatc actgtgcagg aacttttcaa agctcttgga atcaaaatcg aaacaacgag     6600
tgatacgatt tttgaaaaag ttatggaaat tacacaagta catcgttatt tatcaaagaa     6660
aaaattattg atttttatta atgcgtgtac gtatttgaca gaggatgaag tgcaacaagt     6720
ggtagaatat atctctttaa ataatgtgga tgtcctgttt ttagaacaaa gagtggtcca     6780
gaacagattc caatatattt tggacgaaaa cttttatttg agttatgaaa aagcttaaat     6840
tgttattgat tagtggttca ttctaaactg aaatctagct atggataagt gatgcgagta     6900
cggaactttg gagaaaaaat aattctccga ggttttagag tcatgttgtt tagaatggta     6960
ccaaaactaa gcagcttatg ccacttactg gcgtgacgtt ttagagtcat gttgtttaga     7020
atggtaccaa aacttgtgtt tcggtttcag gaacttcggc atcgttttag agtcatgttg     7080
tttagaatgg taccaaaaca cactgctaaa cgacttggca aagagttatg ttttagagtc     7140
atgttgttta gaatggtacc aaaaccgtac tcacaaacaa cgttgcgaca tattagtttt     7200
agagtcatgt tgtttagaat ggtaccaaaa ctttgctgat aaaaatatta taacagaaat     7260
ggttttagag tcatgttgtt tagaatggca ccaaaaccta tagaatggta gtaggtaccg     7320
acgctaagtt ttagagtcat gttgtttaga atggtaccaa aacttaaacg ttctattccc     7380
attcgttccg actgttttag agtcatgttg tttagttttc gcagatacga tttgattgat     7440
gtaaaaatat cgttaatatg tataaatgtg attgttatat aaaaaatata agtaataaat     7500
tgaagctttg ctagagcaag tgacgcgatt acgaaattat ttaattttag agtcacgtta     7560
tttattactt tacgaataga gaatacgatt atctataaat caagaactaa tccccaattt     7620
attgaaaatg acactccctg ttttattaat atttcatgct tttgttgtac tatttgatga     7680
tacaaaaaag taaaactgag gacccaatta aagtcaagtt aaccacattg aaagataaac     7740
ctttcaatgt ggttaaagat gcttaatgag attcatgaaa catagagagc ggattaattt     7800
cctatgttct ttatttgtat attttcttgg gaatcattat tgattgtgga ttaaaaagat     7860
aatccgctcc ccgtttcacc acaggcatat tcgtaatagc taaaatgaag agggctaaga     7920
agaaaagtgc caagattcgg aaagaaaacc attctttaaa gagtgtgtct aattgtaaac     7980
cactttccaa cagaataatt aagggcatat gcaagagata agggtagagg gtatcttttc     8040
cgagggcgct taaaggtaac tttcgtttcg gcaataatgc aaaccaagaa a              8091

<210>  9
<211>  7816
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CRISPR-Cas locus 14

<400>  9
cataaaaaaa cctccttttg gtttgtgaac tgtttctact tcaaagcata aagcgtttag       60
aaaaataagc caaatgatag ggtaaggaag caacctggat ttttgacagt ttagaggaag      120
tgtctgtttt tcacaataaa gtgtaagaaa atgttaaatg aatcaaagaa gaattagtga      180
cgatcactga ggcaaaaaag gggaaagaga taatggctga aaaaaataga accaacattt      240
gctgatttct tgaaaaaact tcgtagtttc tggtttagag agaaagaata tgtttcatcg      300
actaatagat acaagtaatt gaatctcatt tttgttattt aaaaaaaggt ggtttgatta      360
tttaaaatat tcttccagtg gataatcaac taggatcagt cattttggtt ttttttatta      420
ttatgatgat tttgagaaaa gagtgtgata ggatgaatga aaagggtatc atagttgttt      480
ttgtatagtt tttagacgga tgaagtcaaa aaaagcgccg agacagcgct tgctcctaga      540
agctgatgac ggacaaagcc ttattttaac ttgctatatt gaattgaatg ctaccaatgg      600
ttttattata gcatagattg tcagacttac aacaatattt ttgattttgt ttttttatca      660
tgttgagagg tgaggattta agtatggaaa aagagtatac gattggatta gatattggga      720
caaattcggt tggatgggca gtgttgacgg atgattatcg attagtcgca agaaaaatga      780
gtattcaagg agactcgaat agaaagaaaa taaaaaagaa tttttggggt gcacgtttat      840
tcgaagaagg taaaactgca caatttcgac ggatcaaacg aacgaaccgt cgtaggatcg      900
cacgaagacg tcaaagagtt ttagcattac aagatatttt tgcagaagag atacataaaa      960
aagatcccaa tttttttgct cggctagaag aaggagatcg tgtggaagca gacaaacgat     1020
ttgctaagtt tcctgttttt gctacattgt cggaggaaaa aaattatcat cgtcaatatc     1080
cgaccatcta ccatttgagg catgatctag caaactcaaa agaacaagca gatattcgtt     1140
tagtgtactt agcgattgcc cattgcttga agtacagagg gcactttttg tttgaaggag     1200
aattagatac tgaaaatacc tcggtaaccg aaaattatca gcaattttta caagcatacc     1260
aacagttctt tccagaacct ataggagatt tggatgatgc tgtccctatt ttgacagagc     1320
ggctatctaa ggcaaaacga gtggaaaaag tattagctta ttatccatct gaaaaaagta     1380
ctggaaattt tgctcaattc cttaaactaa tggtcggaaa tcaagcaaat tttaaaaaga     1440
cgtttgattt agaagaagaa atgaagttga attttactcg tgattgttat gaagaggatt     1500
taaatgaact gctagaaaaa acaagtgacg attatgcaga attattttta aaagcgaagg     1560
gtgtgtatga tgcgatttta ctttcgcaaa tcctttctaa gtcagatgat gaaacgaaag     1620
ctaagttgtc tgcgaatatg aagttgcgct ttgaagagca ccaacgagac cttaaacaat     1680
taaaagaact agtccgtaga gacttaccta aaaagtacga tgatttcttt aagaatcgca     1740
gtaagaatgg atacgctggg tatgtcaagg ggaaagcgac acaagaagat ttttataaat     1800
ttctaagaac agaactagct ggattagagg aaagccaatc aatcatggaa aaaattgatc     1860
tagagatcta tctattgaaa caacgtacct ttgcaaatgg ggtgattcct catcaaatcc     1920
atttagttga aatgagagaa attatggatc ggcagaaacg tttttatcct tttctaaaag     1980
gggcacaagg aaaaatcgag aaactactga cgtttcgaat cccatattac gtaggaccgt     2040
tggcacaaga aggtcaaagt cctttcgctt ggatcaaacg taagagtccg agccaaatca     2100
ctccatggaa ttttgcagaa gtggttgata aagaaaattc agccattgaa tttattgagc     2160
gaatgacaaa tcaagatacg tatttaccaa aggaaaaagt tttaccaaaa caaagtttga     2220
tttatcaaag attcatgatc ttcaatgaat tgacaaaagt cagttatacg gatgaacgtg     2280
gcaaatctca ctatttttca agtgaacaaa aacgcaagat ttttaacgag ttgttcaagc     2340
aacatccaag agtaacagaa aaacaattga ggaaattttt agagttgaac gagcagatcg     2400
attcaactga aatcaaagga attgaaacgt cattcaatgc ttcttatagc acctatcatg     2460
atttgttgaa attatcagat cagatggata cattattaga tgatcccgat atgacaacga     2520
tgtttgaaga aattatcaaa attttgacga tttttgaaga cagagaaatg attagggaac     2580
aactgaaacc gtacgaaact gtcttaggtc ttccagctat caagaaatta gcaaaaaaac     2640
attatactgg ttggggacgg ctatcggaaa aaatgatcca aggaatgcga gagaagcagt     2700
cccggaaaac cattcttgat tatttgatcg atgatgatga ttttccttgc aatcgtaatc     2760
gaaatttcat gcaactaatc aatgatgatc atctttcgtt taaagaaacg attgctaatg     2820
aattgatcat gagcgactca aacgtattgc ttgatcaagt gaaggctatc ccaggaagtc     2880
ctgcggtcaa aaaagggatt tggcaaagta tcaaaatcgt cgaagaaatc attggtatca     2940
tcggtaaggc acctaagaac atagtgattg aaatggcacg tgagaatcaa agaacaagcc     3000
gttcaagacc ccgcttaaaa gccttagaag aagcattgaa gaatatcgac agtccattgt     3060
tgaaagacta tccaacagat aatcaagcgc tacaaaaaga tcgactgtat ttatattatt     3120
tgcaaaatgg aaaagatatg tatacaggtg aaccactaga gattcatcgt ttatcagaat     3180
atgatattga ccatattatt cctagaagtt ttattgttga taattcttta gataataagg     3240
tcctagtttc atcaaaagtc aatcgtggaa agttagataa tgccccggac ccacttgttg     3300
tcaaaagaat gcgatcacat tgggaaaagc tacatcaagc aaaattgatc agtgacaaaa     3360
aactagccaa tcttacaaaa caaaatctga ccgaggcaga caaggcaaga tttatccaac     3420
gccagttagt cgaaacaaga cagataacga aacatgttgc caatctgtta catcagcatt     3480
ttaatttacc agaagaagta agtgcgactg agaaaacaag tatcattacc ttgaaatcaa     3540
cgttgacaag ccaattccgt cagatgttcg atatttataa ggtgagagag atcaatcatc     3600
accaccatgc ccacgacgct tatttaaacg gagtagtcgc aatgacttta ctaaaaaaat     3660
atcctaagtt ggcaccagaa tttgtctacg gaagttatat caaaggggat atcaaccaga     3720
tcaataaagc aactgcaaaa aaagaattct attctaatat catgaaattt tttgaaagtg     3780
aagaaatcat ttgtgatgag caaggtgaag tgatttggaa taaaaaacgt gatctctcaa     3840
caatcaagaa gacgattggc gcacaccaag tgaatatcgt taagaaagta gaaaaacaaa     3900
aaggtggatt ctataaggaa acaattaatt caaaagcgaa tccagaaaaa ctaattccaa     3960
gaaaagcatc attagatcct ttgaaatatg gtggctatgg tagcccactt gtggcatata     4020
cggtgatttt tatctttgaa aaaggaaaac agaagaaggt aaccaaagga atcgaaggaa     4080
ttaccgttat ggaacaattg agattcgaac aagacccacg agagtttcta aaaacaaaag     4140
gctatgaggg cgtaaaacaa tggctgatat tgcctaaata tatattattc gaagcacaag     4200
gtggatatcg gagaatgatt gcgagtcatc aagaaacgca aaaagctaac tcattgattt     4260
tacctgaaaa tctagttaca ttgctttatc atgcaagaca ttacgatgaa atcaatcata     4320
aagtgagttt tgattatgtc aatgcgcata aagaagggtt taatgacatt tttgatttta     4380
tctctgactt tggggtgcgt tatattttgg ctcctcaaca tcttgaaaaa ataaaagttg     4440
cctatgaaaa aaataaagag gtagatctga aagaaatgat agatgctatt ttatctttat     4500
tgaaatttac gttatttggt gcttctgttg agtttaagtt ttttgatatt aagatattaa     4560
aaagatataa gagtttgacc gacatttggg aagcaaccat tatctaccaa tcggttactg     4620
gattatatga aaggcgagtg gaggtaagga agttatggga tggagaacgc ttgtaatcaa     4680
tacacattca aaattgacct atacaaacaa tcatttgatt tttaggaacg cagaaagaac     4740
agaaaaaatc cacttgtcag aaatcgatgt tctattatta gaaactacgg atatcacgat     4800
tactacaatg ttgctcaagc gtttagtgga tgaaaaagtc cttgtcttgt tctgtgatga     4860
caaacgatta cctactgcaa aattgcagcc attttatagt cggcatgata gcaatttaca     4920
attgactcgg caaatcgaat ggaagaaaga tgacaaagcg agtgtttgga ctgagatcat     4980
cacacagaaa atcaacaatc agcaacgttt tttagaaaag cgtttattta ctgaaaaagc     5040
agaagcaatt gctcagttga ctgccagttt acaattacta gatccaacca atcgagaagg     5100
ccatgcagcc agaatttatt tccaaacatt gtttggaaat aaattcacta gagaagcaga     5160
caatgcaatc aatgctggat tagattatgg atatacttta ttgatgagtc tatttgctcg     5220
agaaatcgtc aagaatggtt gcatgactca atttgggttg aaacatgcca atcagtttaa     5280
tgactttaac ttagccagtg atttaatgga gccgtttcgc ccattagtcg atcaaatcgt     5340
gtacgaggta cgtgagaaag aatttccaat aatcaaacgc agattattcg atctgttctt     5400
aacgaattat tcttatgaga aaaaagagat gttcctgaca aatatcgttg cagattatac     5460
aaagaaagta atcaaagcat taaataaaga agcgaaagga gttccacact tcggaatatg     5520
agttatcgct atatgagaat gatattaatg ttcgatatgc caactgaaac cgtcgatgac     5580
cgcaaagctt atcgtcgttt tcgaaaattt ttgatcagtg aaggcttcat catgcatcag     5640
ttttccgtct atagtaaact cctgcttaac aataccgcca atcaggtaat gatcggtcgt     5700
ttaaaaggga ataatcctaa gaaagggttg atcacgatcc ttacagtaac agaaaagcaa     5760
tttggtcgaa tgatttattt gactggtgaa aaagatcaaa gtatcgggaa tctagatgac     5820
cgagtgatct ttttaggaga ggagttcaat gatgaatctt aatttttcat tacttgatca     5880
gccaatgaaa tttgagcatg cgaatttttt tatcatagaa gacgtgacgg tgtttgctaa     5940
aatgatccaa cagctgtaca cctataaaga aaatggtgaa gtgaagttat tcaatgaacg     6000
gcatgaaacg attaaagaaa gcgaattgat gatgataaca gatattttgg gctttgacat     6060
caattcagcc gcgacactga aattgattta ttcagattta gaaagacaat tgaacgaaaa     6120
gccagaagtg aagtcgatga tcactaaatt gacagatacg atcagtgaac tgattgagta     6180
tgaattatta gaccatgaga tggacttgga aagtgatgag atcacgattt tagaattatt     6240
caaggcgtta ggagtcaaaa tagaaacgac gagtgatacg atttatgaaa aaataatcga     6300
gattttacaa gtatttaagt atctgacaaa aaagaaacta ttaatcttta tcaatgtttg     6360
ttcgtattta acgttgaaag aaatagaaga aatacgatct tatatttctt tatgtaacat     6420
ggatgttctt tttatcgaac caagaaaaat tgcaggaatc acacaaacaa tcttagataa     6480
tgattatttt ttaatagatg gtagtatggt agaataaaag aaaataagta ttcaattctg     6540
aagttttgct atgaacgaat cgcgcgatta cgaaactttg tcagaaaaaa ttttttctac     6600
gaggttttag agctatgttg aattgaatgc ttccaaaacc atccatttcg tcgatatggt     6660
catcgccctg ttttagagct atgttgaatt gaatgcttcc aaaacagatt gatacaaatc     6720
tcaaaacatc tgcaagtttt agagctatgt tgaattgaat gcttccaaaa cgtagagaag     6780
cggtgctacc tcttaaacca tgttttagag ctatgttgaa ttgaatgctt ccaaaacaac     6840
cagaagcgaa taagcgtcct atcatctgtt ttagagctat gttgaattga atgcttccaa     6900
aacagacgcc cgaatgttta tcaccacaac ggagttttag agctatgttg aattgaatgc     6960
ttccaaaact tgcaacacaa aggtaacata ggtgttgtgg ttttagagct atgttgaatt     7020
gaatgcttcc aaaaccatac tgttgtgcat cgaatgcacg ttggagtttt agagctatgt     7080
tgaattgaat gcttccaaaa ctagaattga acacatgtat ctagatattg agttttagag     7140
ctatgttgaa ttgaatgctt ccaaaacaat aaatggacga ataataatcc ttagagagtt     7200
ttagagctag gttgaattga atgcttccaa aacaacatac ttcattaatg atcctaaaaa     7260
gtcgttttag agctatgttg aattgtctgc cattactagc tatactggat ctcagtaaaa     7320
agatgatagt gggattcact aataaaaagt acagagtcag aagaaaacac agacacttgt     7380
gttttctttt tttgctcaaa ctggacgaaa ctctttactc ttagtaggat aggagtagaa     7440
gaaaaagtgg ggtgtaaaga tgtttagtga aacgttggtc catttgttgg aatgggtgac     7500
tgcgattttg aatattttct cgattttagt cttgttggtt ggaatttttt tagttttaaa     7560
aaatttgatg ttggaacgtc cattgattaa agattatgcg acacgtaatc ggcgcaatgc     7620
ggatattcga aaactactag ctagttacat tttgttgagt ttagaagtac tgatcgtggc     7680
agatctcatc gaatctgtca ttaaaccaac ttggacagac attttaaaat tagcattgat     7740
cattatcatt cgcacgatca tctcttattt cttaaattta gaaattgcga gtcatgtatc     7800
gcatgaaaga agggaa                                                     7816

<210>  10
<211>  8221
<212>  DNA
<213>  Enterococcus faecalis

<400>  10
attgcgaaac aagcagctaa attcccaagt gtttttaaag ccgattatgg tggtgtaaac       60
tcagacaaaa tctttaaaat cgctcaaacc gttcgaactt ggggcttagc agctgctgca      120
ttacttttat tcgttgcagt gttcttaatt tccaacacca ttcggattac gattttatct      180
cgtcaaaaag aaatccaaat tatgcgtctt gtaggagcga aaaacagttt cattcgttgg      240
ccgttcttct tagaaggtgc ttggattggg ttgattggcg caatcgtgcc agtcatcatt      300
atgacgttag gctaccatca agtttataac atgtttaacc cgcagttatt gcgttcgaat      360
tattcattaa ttcgtccaga agattttatc tggaaagtta atctattaat gattgcaaca      420
ggaatgatta ttggatcact aggttcagtt atttcaatgc gtcgtttctt gaaaatttaa      480
aaaagtataa ttttgcggac aaaaaccttg ccatctaagt gatttatcac atagagattg      540
ctaagatgag agaaatgttt ttgttcagta ggctatctta aaagttaaaa aatgacacat      600
aagttgactc gacttatgtg tcatttttta gttaataatc aacacaccaa tccatcggaa      660
aatctgtagt agattttgta tacgggagga cctatctgat ggtaaaattt attgccatat      720
gcttaaaacg tatatattat ttaagcataa gcagataacc gtagattaaa attgtggaaa      780
ttgttatttt ttctttctaa atcatgataa attaaagggg taatagttat cataaatttc      840
tgaaaattat ttattgaaaa ttgtatccct ttacaaaaaa tattgtataa ttaaattatt      900
aattgtcatt gcttaaagga ggttctcatg tacagtatag gtttagattt agggattagt      960
agtgttggtt ggtcagtaat tgatgaacgg acaggcaatg ttattgattt aggtgtccgt     1020
ttatttagtg cgaaaaatag tgaaaaaaat ttagaacgac gcacaaatcg aggtggacgt     1080
cgtttaatta gacggaaaac gaatcgctta aaagatgcaa aaaaaatact tgcggctgtt     1140
ggattttatg aagataaatc attaaaaaat agttgcccgt accaattaag agtaaaagga     1200
ttgacagaac cattaagcaa aggagaaatt tataaagtga ctcttcacat tttaaaaaaa     1260
cgtggaatta gttacttaga cgaagatgat acggaagcag cgaaagaaag tcaagattat     1320
aaggaacaag ttagggaaaa tgctcagttg ttaacaaaat atacgccggg tcaaatccaa     1380
ttacagcggc tgaaagaaaa taatcgagtg aaaacaggaa tcaatgctca aggtaattat     1440
cagttaaatg tttttaaagt ttctgcttat gcaaatgaat tggcaaccat tcttaaaacc     1500
caacaagcct tttatcctaa cgaattgaca gatgattgga ttgcattatt tgtacagcct     1560
ggtattgcag aggaagctgg attaatttat cgcaaacgac cgtattatca tggaccagga     1620
aatgaagcca ataacagtcc ttatggtcgt tggtctgatt ttaaaaaaac aggccaacca     1680
gcaacaaata tttttgataa attgattggc aaagactttc aaggtgaact acgagcaagc     1740
ggcttaagtc tatctgcaca acaatataat ttactcaatg atttaaccaa tttaaaaatt     1800
gatggagaaa taccactttc gctagaacaa aaagaataca ttttagcaga attaatgacc     1860
aaagaattta ctcgttttgg cgttaatgat gtggttaaat tgctgggtgt aaaaaaagaa     1920
cgattaagtg gttggcgttt ggataaaaaa ggtaaaccag aaattcatac attaaaagcc     1980
tatcgcaatt ggcggaaaat ttttgctgaa gcagggatcg atttggctac gttaccaaca     2040
gaaacgattg actgtttagc gaaagtttta accttaaata ccgaacgcga agggattgaa     2100
aatacattag cttttgaact gcctaagtta gcagaaccag taaagtcact agttttagat     2160
cattacaaag aattaagcca aagcattagc acgcaagcgt ggcatcgttt ttctttaaaa     2220
acattacact tattaattcc agaactaatg aacgctacct cagaacaaaa tacactctta     2280
gaacagtttc agttaaagtc aggtgttaga acacggtata gtgaatataa taaattacca     2340
acaaaagatg tcttggcaga aatttataat ccaacggtga acaaaacagt gagtcaagcc     2400
ttcaaagtta tggatgcttt gttggaaaaa tatggcaaag agcaaattcg ttacatcact     2460
attgaaatgc ctagggacga taacgaagaa gatgaaaaaa aacgaataaa agaattacat     2520
gcaaagaata gtcaacgaaa gaatgacagc caaagttatt ttatgcaaaa gtctggatgg     2580
agccaagaaa aatttcaaac gaccattcaa aaaaatcgtc gttttttagc taagttatta     2640
tactattacg aacaagatgg catatgtgcc tatacaggac tgtctatttc tcctgaatta     2700
ttggttagtg attcaacaga aattgatcat attattccaa tttcgattag cttagatgat     2760
tctattaata ataaagtact ggttttaagt aaagctaatc aagtcaaagg acaacaaaca     2820
ccatatgatg catggatgga cggttctttc aaaaaaacta acgggaaatt tagcaactgg     2880
gatgactatc aaaaatgggt ggaaagtcgc cattttagtc ataaaaaaga aaataattta     2940
ttggaaacgc ggaatatttt tgacagtgag caagtcgaaa aatttttagc tagaaatctg     3000
aatgatacgc gttatgccag tcgtttagtt ttaaatacct tacagagttt ttttgcgaat     3060
cagggaacga aagttcgagt agtgaacggc agttttactc atactttacg taaaaaatgg     3120
ggtgccgact tagataaaac tcgtgaaaca catcatcatc atgccgttga tgcaacattg     3180
tgtgcagtca ctccgtttgt caaggttagt cgttatcact atgcagtgaa ggaagaaact     3240
ggtgaaaaag tcatgcgtga aatcgatttc gaaactggtg aaattgtcga tgaaatgtct     3300
taccaggaat tcaaaaaatc aaagaagtat gaacgaaaaa cctatcaggt aaaatggcct     3360
aattttcgtg agcaattgaa gccagtaaac ctccatccaa gaattaaatt ttctcaccaa     3420
gtggatcgta aagctaaccg caaactcagt gatgccacta tttattctgt tcgagagaaa     3480
acggaagtca aaacgctgaa aagtggtaaa caaaaaataa cgactgacga gtacacaatc     3540
ggtaaaatca aagacattta cacggtagat ggttgggaag ccttcaagaa aaaacaagat     3600
aaacttttaa tgaaagatct tgacgaaaag acctatgaac gattgttgtc tattgcagaa     3660
acaactcctg attttcaaga agtggaagaa aaaaatggta aggtaaagcg tgttaaacgt     3720
tcaccgtttg ctgtttactg tgaagaaaat gatattccag cgattcggaa atatgcgaaa     3780
aaaaacaatg gaccacttat tcgtagtttg aagtattatg acggtaaatt gaataaacat     3840
attaatatca ccaaggattc acaaggacga cctgttgaaa aaactaaaaa tggtcgcaaa     3900
gttacactac aaagtttaaa accatatcgc tacgatattt atcaagattt agaaactaag     3960
gcttattata cagtacaact atattattct gacttacgtt ttgtggaagg taagtatgga     4020
atcacagaaa aagaatacat gaaaaaagtc gccgaacaga caaagggaca agtggtgcgt     4080
ttctgttttt ctttacaaaa aaatgatggt ttggaaattg aatggaaaga tagccaacgc     4140
tatgatgtgc gtttttataa tttccaaagt gctaatagta ttaactttaa agggttagaa     4200
caagaaatga tgccagcaga aaatcaattt aagcaaaaac cttataataa tggagccatc     4260
aatttaaata tcgctaaata tggcaaagaa ggcaaaaagt tacgaaaatt caatacagat     4320
attttaggaa agaaacatta tctgtattat gaaaaagaac caaagaatat tattaaataa     4380
aaaagaagaa acgaaaagaa aagggttgca tgattagcgt ttttgtagta atctttaatt     4440
gtagtcgacg gactaccgcg tttgacgaaa cgtgtcttta ataattttac tgataagaaa     4500
ttattgagaa tctacaaaaa taaggcattt tgccgaattt accgccctac atatgtaggg     4560
cggttttttt attaaaaagg aggaaatgtt gttgggattt cgaacagttt tcgtaaaaaa     4620
tggcgagaaa ttaaaagtaa agttagataa tttagaagtg ataaaagaag ggaatacata     4680
tgtcattcct ttgacagata ttgaaagtgt aattttagaa ggcgaccaga cattcatcac     4740
tacacggtta ctagcgaagt tcgcacaaca tcatattgat accgtgattt gtgataatac     4800
gttcatgcct gtaggtgttt ttcttggtat tggacagtat catcgcagtg cgaaacgagc     4860
aatctggcaa agtaattgga cagaagaaca taaacaagta gcgtggtgcg aaattgtaac     4920
acaaaaaatt cagaatcaaa tcgcagttgc gaaatattta ggaacagatt ccgaacgagt     4980
ggaagtatta gaaaaactta gtgaaggaat tttaccaggg gatacaacga atcgtgaagg     5040
acatgttgca aaagtatatt ttcattcatt gtatggtgtg ggttttaccc gtgaagaaga     5100
gtgcttacca aatgcctgta tgaattatgg ctatgcagtt attcgtgcac aaatggcccg     5160
ttgcgtggta gcgttaggat tattaccgat gttagggatt ttccataaaa atgaatataa     5220
ttcgtttaac ctaattgatg acttaatgga accttttcgt ccattaatgg attggtatat     5280
tcatcaaacg atattgaaaa agaatgaaaa gtatttaacc tatcatagtc gtttaacctt     5340
agtggaattt ttacatcaaa agattaaggt gaaaaacaaa aaaatttata tgaaccaagc     5400
aatgtctgaa tatgtagctg cttttgtgaa agcaatggaa acaggtgatt ttgaaaacgt     5460
tcagaaaatt catttggtca atatgttgga gtgtgagggg aagtgagttt aggagtcgtg     5520
cgattaatgt gtttatttga tttacccttt gaaacgaaac aggagcaaaa agaataccga     5580
atttttagaa aacatttact ggaaaacgga tttattatgt tgcagtattc tatttattat     5640
cggagtttgc ccaatcgtag tgcgttaaaa aaatatgaaa caattctaaa gagaaaagta     5700
ccacgttcag ggaacgttcg attgttgtat gtttcagaaa ttcagtttca agatatgcta     5760
ttattggcgg gcagtcgtag tcatcaagaa gaagtagttg gcgttcaccg attggtggtg     5820
atttaatgaa acaaattcgt ttagaatatc agtatcaaca atttattgaa ttctctttgg     5880
aagattatgt atttttttat ggaggagaaa accaatggcg tcgtaaaata ttacgaacat     5940
taaaacggtt tgcgaaacaa aaagcgttaa gtgacttaga agaatcagtc tatggagata     6000
acggtattga aattttttta gaagaaaaaa agttaaaggc aaagagtatt gatttttact     6060
ttttagagga caatacaagt atttttcaac aaatgaattt tatcaaaggt acgttacttc     6120
accaggaatt actttattta caagatgatt ttgatattac aaatcaaatg agcaatttaa     6180
atgatcagtt gttaaaacta gaaaatttaa tgaatgataa attaaataac tatttaacga     6240
atattgaacc gcatttttta gaaatgaatt ttcaggatat tttgaagtat tcgttgtcat     6300
taaactattt agaaaatggc caatcgttgc ctttagaaat gatggataca agggaattgt     6360
tggctgaatt tatttatctc ttgcaacgga gtatcagccg aagagaacag cctgtctggc     6420
ttgttattac aaatccagaa agttttttgg agacggaatc aatttattat ctctttcagc     6480
agctaaagaa attggctcaa gaaacaaagc agttgaagtt ttttattttt agtaatagaa     6540
gcttgccttt accgtatacg gaggaagatg ttgagaaaac gattttgtta tatgataagt     6600
atcagcagtt gccagttttt gatgtttttc gtcaaagtat tgagcgacat tatccagatc     6660
aactctcttg gacaaatcaa caactaattg atgcttttta tcgagtctgt cattttgttg     6720
gtgatcagta tacaaaaaat tatcttttac ctaaagatat gatattatta aaattgttga     6780
aggaattgtt agacgacaat agtgagtgtg tcgagacgtc gatggaaaag ctcactgtat     6840
tggaagaaca atattttcgc gaacggttat tgcggaaaga gtgagtctgg aattttaacc     6900
gcgtaaagtt atatttttta tcaaaaggat tattaatgag atttcaaatt ttaaatttga     6960
ggtttttgta ctctcaataa tttcttatca gtaaaacttg aaacacataa tcattaaccg     7020
ctttttggtt tttatactct caataatttc ttatcagtaa aacaaaattc ttctaacgtt     7080
tgcgctgaaa tatgtttttg tactctcaat aatttcttat cagtaaaact gtttattctg     7140
cggtttctcg ccaaattaag tttttgtact ctcaataatt tcttatcagt aaaaccactt     7200
catatacctt ctaaacgagt tattagtttt tgtactctca ataatttctt atcagtaaaa     7260
cggatgtacc agttattctt ggtctttcaa agtttttgta ctctcaataa tttcttatca     7320
gtaaaactgt tcctcttgat ggtgctgacg gcaaccagtt tttgtactct caataatttc     7380
ttatcagtaa aactgtctct ttgatggctt cctttttaac cagtttttgt actctcaata     7440
atttcttatc agtaaaacaa aaaccagatt tagaaactat taaagatagt ttttgtactc     7500
tcaataattt cttatcagta aaacgctttt tctcctgcaa actcttcgat ctgagttttt     7560
gtactctcaa taatttctta tcagtaaaac caactagttc agtaatttcg ccttcacttt     7620
gtttttgtac tctcaataat ttcttatcag taaaacaaac gataccttat accattgaat     7680
ataatggttt ttgtactctc aataatttct tatcagtaaa accgttccat tgctttaaac     7740
tagtatcgga aggtttttgt actctcaata atttcttatc agtaaaacag ttcgcttatt     7800
cccatcatgg cacagaccgt ttttgtactc tcaataattt cttatcagta aaactggaac     7860
atgagagtgg tttaaaccct gctagttttt gtactctcaa taatttctta tcagtaaaac     7920
gcacctagaa cgacgtcaat cggttggttg gtttttgtac tctcaataat ttcttatcag     7980
taaaacgcaa aatgcccgct gctatctatt caacgagttt ttgtactctc aataatttct     8040
tatcagtaaa actaaagatg gcaatcctaa gccaaggctt gagtttttgt actctcaata     8100
atttcttatc agtaaaacac gtgtcgtcgt aagttgttgc agtccatggt ttttgtactc     8160
tcaataattt cttaccagta aaacaataag gaagtaggtt ggatgtacaa actcgctttt     8220
a                                                                     8221

<210>  11
<211>  8221
<212>  DNA
<213>  Artificial sequence

<220>
<223>  CRISPR-Cas Locus 16

<400>  11
aagtagaccc ggcttcagta actgaaaaag ataaaaaacc tgcagatctt gaagcacact       60
tgaaaaatcc tgacttcttc gatacagcaa aaaatccaac ttctgacttt aaaattacca      120
gcgtaacaga tcttaaagaa gcaccgaaag atgcagtagc tggagctaac aaaacagtaa      180
gcggaaacct taccctatcc ggaaaaacaa tgaacgttac gttcccggct aaagtagacg      240
ttgcagaagg tacagcagct attcaggcta aatttacagt gaacagagca gactggggga      300
tcaaattcgg aacttctgaa gcagaccctg cagaatggat gatcagcaaa gacatcgaaa      360
tcgctgtaga cgtaaaagct aaaaaataat attgttagat attcaattct ttgagctgcc      420
ttttttaagg tggctttttt ttgtgcttta aatttttgta cttaaaaacc tttaaatggg      480
aaaaggcgag ttaccccgcc ttgaatgttt tcacaacgga ataatcctta ttgtgaattg      540
ctttcggtta caaatctaaa aattattttt ttaactgttt tatggtttcc cataaaatga      600
ttactttttt tctctttatt tttatgcttt atgaaaacca aatagcaatg actaaaaata      660
tactaggatt agacttagga acgaactcaa taggatgggc attgataaaa caggattttg      720
aaaacaaaca aggtgaaatt cttgggatgg gaagcagaat tatacctatg tctcaggata      780
ttttggggga atttggaaaa ggaaattctg tttctcaaac tgcttctcgg actagctata      840
gaggtgtgag aagattacgt gaaagatttc ttttgcgaag ggaaagatta catagagttt      900
taaatgttct gaacttttta cccgcacatt atgcttctca gatagatttt gaaaagaggt      960
ttgggaaatt caaagaagaa actgagccta agttggttta tgacgtgaat gaatttattt     1020
ttaaaaattc gtttgaagaa atgctttatg attttagaaa gtatcagcca cagcttttag     1080
aaaatgataa aaaagttccc tatgactgga cgatttatta tttacgtaac aaagccttaa     1140
cccaaaaaat agagaaagaa gaacttgctt ggattctttt aaattttaat cagaagcgtg     1200
gttattatca attacgtggg gaagattttg aagaagaaaa agataaaact tttgtacgcc     1260
taaaagttga taaaattgtt gattcgggag acactataaa gggcaaaata ttatatgatg     1320
tttatttcga aaatggctgg aaatatgata aacagattgt aaaaacggaa gattggatag     1380
aacgtgtaaa agaatttatt gttacagaat cattcttaaa aaacggcgat ataaaaagaa     1440
cttttaaagc tgttgattct gaaaaggatt ggattgctat caaaactaaa acagaacaag     1500
aaattgataa ttcgaataaa accgttggga catacattta tgaaacactt cttcgaaatc     1560
caaaacaaaa aattaaagga aaattggttc gtacgattga aagaaaattc tataaagatg     1620
agctgaaaca gattctggaa aaacaaaaag aatttcatct tgaattaaag aatgatgatt     1680
tatatagtga ttgtattcgt gaattgtatc gaaataatga agcgcatcaa ttgacgttga     1740
gtagaaaaga ttttgttcat cttttgatgg aggatattat tttttatcaa agacctttaa     1800
gaagtcataa atcttctatt tcaaactgta ctttggaatt tagaaaatat aaagatgaaa     1860
atggagcaga gcatattcaa tatttaaaag cgattccaaa atcaaatcca tattatcagg     1920
aattcagaat ctggcaatgg atttttaatc tcaatattta taagagagat gacgagcaaa     1980
atcctgttac aaaaaagttt ttaaacacca cccaagattt tgaaaatctg tttgaatttc     2040
tgaataacag aaaagaaatt gaccaaaagg ctttactcaa acatcttaaa ataaatgaga     2100
aaacgcatcg ttggaagtat gtagaagaca aaaagtatcc ttgcaacgaa accaaaacaa     2160
tgatttcatc aaggttggat aaagttgaaa atatttctga aaacttcctg acaagagaaa     2220
ttgaacagaa gatttggcat attatctatt ctgtcaacga taaaattgaa tatgaaaaag     2280
ctttaaaatc ttttgccaat aaaaataatc tggacgaagt ttctttcttt gaagctttta     2340
aaaaattccc accttttaaa agcgaatatg gttctttttc tgaaaaagca ataaagaaac     2400
tgttgccttt aatgcgattg ggaaaatatt ggaattatgc tgatattgat aaatattcaa     2460
aagacagaat tcagaaaatt atcaatggag aatatgatga aaatatcaaa gacaaggtaa     2520
gggaaaaagc agttcatctt acgactgaaa atgattttca aggtcagcaa ttgtggctgg     2580
ctcaatatat tgtttacgga aggcattctg aagcttcaat gattggaaaa tggaattctg     2640
ccgatgattt ggaagagttt ttaaaagagt ttaagcaaca ttcgcttcga aatccgattg     2700
ttgagcaggt cattaccgaa actttgcgcg ttgtaaaaga tatttggttg aaatacggaa     2760
atggagcgaa agatttcttt aacgaaattc atattgagtt gggaagagaa atgaaacttc     2820
ctgcagatga tagaaaaaaa ctaacgaacc aaatttctga aaacgaaaat accaatcttc     2880
gtatcaaggc tttgctggct gaaatgataa acgaccattc tgttgaaaat gttcgtccgt     2940
tttcgcctat gcaacaggaa attttgaaaa tttatgaaga tggagtattg aattcaggta     3000
ttgaaattga agatgaatat ttgaaaatca gcaaaaccgc acaaccttct ccgtctgatt     3060
tgaagagata caaactttgg ttggaacaga aatacaaatc gccttacaca ggacaaatta     3120
ttcctttaaa taaattgttt acgccagaat atgaaattga acatatcata cctcaaagcc     3180
gatattttga tgacagcttt agtaataaaa ttatttgtga atcagccgtt aataaattga     3240
aggataatta tatcggactt ggatttatta agcaattcgg agggactatt attgagcttg     3300
gttttggaaa aaatgtaaag gtttttgaag tcgaagaata tgaagatttt gtcaaaaaac     3360
attatgcaaa taatcgaagt aagagaaata aacttttatt agaagaaatt cctgaaaaaa     3420
tgattgaacg tcagttgaat gatacacgtc atatcagtaa gtatatttca ggtgtgcttt     3480
ccaatattgt aagagtagaa gatggaacag atgaaggtgt aaattctaaa aatattgttc     3540
ccggaaacgg aaaaatcaca actcaattaa aacaggattg gggactgaat gatgtttgga     3600
atgatttgat actgccacgt tttgaaagaa tgaatcaact aaccaattca acagatttta     3660
cagcttggaa tgaaaatcat caaaagtatt tgccaactgt tccgattgag ttttcaaaag     3720
gattttcaaa gaaaagaatc gaccatcgtc atcacgcttt ggatgctttg gtgattgctt     3780
gtgctacaaa agaccacgta aatttattga ataatcaatc tgcaaaatcg gagacgaaac     3840
gttacgattt gaaaaagaga ttgatgaagt ttgaaaaagt tgtttacaat catacacaaa     3900
caggagagaa aatcgaaaga gatgttccga aaaagttttt gaaaccttgg gaaaacttta     3960
cggttgaagc taaaaacagt ttggagaaaa taattgtaag ctttaagcaa aatctcagag     4020
taatcaataa agctacaaat tattatgaaa aatatgtgga gaaagatggc ttgaaaacga     4080
aagaaagggt agagcagacc ggaacgaact gggcgataag aaaatcattg cacgaagaaa     4140
ccgtttcagg gaaaattaac ttgccttggg tggaaacaag caatggagaa tttattactg     4200
ccacaagaaa gtctttggac acaagcttca atttggaaaa aatcaaaaaa attacggata     4260
tcggaattca gaaaattctc agaaattatc ttgaggcaaa agatggcaat cccgaattgg     4320
ctttttcgcc agaaggaatt gaagatctga ataaaaatgt tgaaaagtat aatgatggta     4380
aatcacatca gccaattatc aaagttcgtg tttatgaaaa aggcaaagga aggtttgtct     4440
tagggcaaac aggaaataaa attgataaat acgttcaggg ttcccctaac ttatttttcg     4500
caatatataa agatgataat ggtaaaaaaa gttatgaaag tattcgttta gatattgcga     4560
ttgaaagatt aaagcaaggt ttgcaagcag ttccagaaac aaatcaaaat ggatttgcat     4620
tgtatcaaag cctgtctcct ttagatttag tttacattcc cacagaggat gaagttgaat     4680
caccacatct aattgatttt agtaaattag ataagataaa attggaaagg atttataatg     4740
taaatgactt ctcaggatat acaatttact tcagccaaaa ttcatttgct aaaaacattt     4800
atcctaaaga gatggatatg acctggaacg aaaaaaaaca aaaaccatca ggttcgtttg     4860
attctaaaac agcttcatac aataaaaaat cgattaaaga tatttttatt aaaatgaaaa     4920
ttgaccgttt aggaaatatt tcaaaagcgt aattatgata acccgctcca tctacatcgg     4980
caatcccgct tatctcaaac taaaagatga gcagatgaaa atcctctgtc cggaaaccaa     5040
atcggaaaag ggtagtatac ctgtggaaga tttgggacta ttgatgttgg atcattttca     5100
gattacgatt tcacataatc tgattcaaaa aatgatggga aataatgtgg tggtggtaag     5160
ttgtgatact catcatttgc cacacggaat tatgttgccg ttgtatgggc atacagagca     5220
ttcggatcgg gtaaaagacc agttggaagc cagtgaacct ctgaaaaaac aactttggaa     5280
acagacggtg gaatgtaaga ttgaaaatca gaaaaacgtt ttaatgaagt tggggaatta     5340
ttatgaacct atgattgaat atcaaaaaaa tgtaaagtcc ggcgatatca ccaatatgga     5400
aggtattgcg gcgcaacatt actggaaata tttaatcagt cttgattttc ttcgacaacg     5460
ttttggagat tcacccaatc agttttttaa ttttggatat gcagttctca gaagtattgt     5520
agcaagagct attgtggaaa caggactgct tccggtgttg ggtatttttc ataaaaataa     5580
atacaatccg tattgtcttg tggatgattt aatggaacct tatcgaccgt ttgtggattt     5640
gctggttatg cagtggctga aaattaatcc tgggactgaa gaactgacaa aagaatttaa     5700
agcatatatt cttcagattg cgaccaaaga tgtattgatt gataataaaa caagaccttt     5760
gttagtagct gtaaaaacaa cagcttcttc gctttataaa tgttatacag gcgaaaaacg     5820
attaatttcc taccctgaat tgagatgaat tccgaaaggt ttaatgcata ccgaattatg     5880
tgggttttag tattatacga tttaccgact gaaactaaag ctaatatgaa agatgcaaac     5940
cgctttcgta agagtttaat tgatgatggt tttacattat ttcagttttc gatgtatgtc     6000
cgccattgtc cgagtcggga aaatgctgaa gtgcatatca aaagagttaa gtttatgcta     6060
ccaaaagctg gtaaagtcgc tattatgtgc attacggata agcaatttgg agatattgaa     6120
attttctttg ccagaaataa agaagaacca cctccaacct ttcagcaact ggaattattc     6180
tgatttttta aatcctaaat tataaataaa cccactgtaa ttcagtgggt taaattttga     6240
ggttgtgctg tatctcaaag atacggataa atgaaagcaa ttcacaacag ttactgctgt     6300
tgatcaaaat tcttctcagt tgtgctgtat ctcaaagata cggataaatg aaagcaattc     6360
acaactaaaa tgggcgcaat tcacttgata agagtgttgt gctgtatctc aaagatacgg     6420
ataaatgaaa gcaattcaca acaccaaaag cttgatacga ttatacaact cagttgtgct     6480
gtatctcaaa gatacggata aatgaaagca attcacaacc tttgcagtcc atatacaccg     6540
atccgtaaag ttgtgctgta tctcaaagat acggataaat gaaagcaatt cacaacgaaa     6600
ttggacgcta tgtaataatc atccatagtt gtgctgtatc tcaaagatac ggataaatga     6660
aagcaattca caacagaaac tctaaagctt ctttttgatt atcggttgtg ctgtatctca     6720
aagatacgga taaatgaaag caattcacaa ctgatacgtt ctagcagtag cggttaatgt     6780
agttgtgctg tatctcaaag atacggataa atgaaagcaa ttcacaacaa gataaaaaaa     6840
taacagaaca ggattatagt tgtgctgtat ctcaaagata cggataaatg aaagcaattc     6900
acaacaagat aaaaaaataa cagaacagga ttatagttgt gctgtatctc aaagatacgg     6960
ataaatgaaa gcaattcaca actcattatg ctccatatta ttctcctagt tagttgtgct     7020
gtatctcaaa gatacggata aatgaaagca attcacaaca agataaaaaa ataacagaac     7080
aggattatag ttgtgctgta tctcaaagat acggataaat gaaagcaatt cacaacctta     7140
taatgatagt tctataaatt atataggttg tgctgtatct caaagatacg gataaatgaa     7200
agcaattcac aacttagtag cataaataac agctaattga gcagttgtgc tgtatctcaa     7260
agatacggat aaatgaaagc aattcacaac aaagttatta tttatttata tataagaaat     7320
gttgtgctgt atctcaaaga tacggataaa tgaaagcaat tcacaacaaa ttggagatag     7380
tgatgaggat tccttatgtt gtgctgtatc tcaaagatac ggataaatga aagcaattca     7440
caacaagagg ctccggaagt atcaggatac atatgttgtg ctgtatctca aagatacgga     7500
taaatgaaag caattcacaa ctcaattaat atgaaattga aattactatt tgttgtgctg     7560
tatctcaaag atacggataa atgaaagcaa ttcacaacca ttaatctgaa attgaaatta     7620
ctatttcagt tgtgctgtat ctcaaagata cggataaatg aaagcaattc acaacaattc     7680
tcaaactcat atccagcagt aggatgttgt gctgtatctc aaagatacgg ataaatgaaa     7740
gcaattcaca accgttatga aaaagtcagt taaaaaaaat atagttgtgc tgtatctcaa     7800
agatacggat aaatgaaagc aattcacaac tctgaaacgc cataattaat ttatcaggct     7860
gttgtgctgt atctcaaaga tacggataaa tgaaagcaat tcacaacccg agaacctatc     7920
caaagaagat ttgtaatgtt gtgctgtatc tcaaagatac ggataaatga aagcaattca     7980
caactcgaga aataatattc tggtttcact tggagttgtg ctgtatctca aagatacgga     8040
taaatgaaag caattcacaa cccgaaaatg gtataaagtt acgttatttt agttgtgctg     8100
tatctcaaag atacggataa atgaaagcaa ttcacaacta atttcgtacg aagtttatac     8160
tcgtttaggt tgtgctgtat ctcaaagata cggataaatg aaagcaattc acaacctacg     8220
t                                                                     8221

<210>  12
<211>  7304
<212>  DNA
<213>  Artificial sequence

<220>
<223>  CRISPR-Cas Locus 17

<400>  12
tttgaagcca gaaacaggat gtcattattt ttctggctca taataattct ggctaaaggt       60
tccagccctt tctccttagc tgtatcagct ttggtttttt ttcgcttttt gaaaggcaga      120
taaaggtctt ccagctcctg tatatcaaag ctttcttcaa ttctttgctg aagttcaggc      180
gtcaaagcat tctgttcttc tatcgatttt aaaatggatt cctttctctt aacgatctct      240
tcaaattgct tactgatctt tgaaatctgt tcaatctgta tttcatcaag gtttccggtt      300
ttatcttttc ggtaacggga aataaaagga atggtgcagt cttctgctaa taattgtaag      360
gtattgttga tgctcttttc agaaatattg agctgcttct gtataaattc tacggtcgtc      420
attgttctgt tttcggatcg ctaaaatagg gttttaaaac gaaaaaaggc gagttgcccc      480
gccttgaatg ttttcacaac ggaataatcc ttattgtgaa ttgctttcaa aatttatatg      540
acaaatatag aagaaaaaat atttaataca attatgggaa tccgtaattt gaatgctttt      600
tttatttata ttttaggtga tattcaaaac ataactgtga tgattaaaaa taaacttggc      660
ttagacttgg gaacgaactc cataggatgg gcattgataa gacaggattt tgaaaacaaa      720
tacggagaaa ttcttgggat gggaagcaga attattccga tgtcacaaga tattctgggc      780
gattttggaa aagggaattc tgtttcgcaa accgcagaac gaacaaaata tagaagtgtg      840
agaagattac gtgaacgatt tttattgagg agagaacgac tacacagact tttacatctt      900
ttaaattttc ttccacaaca ttatgcttca caaattgatt ttgaaaaaag attcggaaag      960
tttaaagtgg aaaccgaacc aaaactggct tggaaaaata ttgaaggaaa attttcattc     1020
cttttccaaa actctttcaa tgaaatgctt gaagatttta atgcaaatgg acaggattta     1080
aaaattcctt acgactggac aatttatttt ctccgaaaaa aagcactttc acaaaaaatt     1140
gaaaaggaag aattggcgtg gattctttta aactttaatc aaaaacgtgg atattatcaa     1200
ttgcgtggtg aggaagagga agagaatcct aataaacagg ttgagtttta ttctttaaaa     1260
gtcatagacg ttttagcaga tgaacctcaa aaaggaaaat ctgatatttg gtattctttg     1320
attttagaga atggatggat ttacagacgt tcaagtaaaa ttccattatt tgactggaaa     1380
gataaaacaa gagattttat tgtaaccacg gacttgaatg atgatggaag cattaaaaaa     1440
gataaagacg gaaatgaaaa aagaagtttc cgtgcgccgg gtgagaatga ttggactttg     1500
gtaaaaaaga aaaccgagca ggaaatcgag caatctcaca aaaccgttgg aacctacatt     1560
tacgaagcac ttcttgataa tcccaaacaa aaaataaagg gaaaactgat tcgtaccatt     1620
gaaagaaaat tttacaaaga agaactcaga cagattttag aaaagcaaaa ggaatttcat     1680
caggaattac aaagtgatga tttgtataat gattgtattc gtgagttgta ccgaaacaac     1740
gaatcacatc aacttatttt gagcaagaaa gattttgttc atcttttgat ggaggatctt     1800
attttctacc aaagaccgct gagaagccag aaatcttctg tttctaactg taccttggag     1860
ttcagaaagt ataaagatga aaatggagca gaacatatac aatatttaaa agccattccg     1920
aaatctaatc cttattatca ggaattccgc ctttggcaat ggatctacaa tttaaacatt     1980
tatagaaaag atgatgaagc gaatgttacc aaagattttt taaatacgac ccaagattta     2040
gaaaatctgt ttgagttttt aaatatcaga aaagaaattg accaaaaagg attactaaaa     2100
cattttaaac tcaatgaaaa aaaacatcgt tggaattttg tagaagaaaa gaaatatcct     2160
tgcaacgaaa ctaaaacgat gatttcttct cgattggata aagtggataa tatttctgat     2220
gatttcctga caagggacat tgagcagaaa atttggcaca tcatttattc cgttaatgat     2280
aaagtagagt acgagaaagc cttaaaatct tttgcgagaa agtatcatct ggatgaaagt     2340
tctttttttg aggctttcag aaaatttccg ccatttaaaa gtgaatatgg ttccttttcg     2400
gaaaaagcaa ttaagaaatt gttggctttg atgcgattag gaaaatattg gaactatgca     2460
gatgttgata aattttcaaa agacagaatt cagaaaatca ttaacggaga atatgatgaa     2520
aatattaaag ataaagtgag agaaaaagca ataaatctca catcagaaaa tgattttcag     2580
gggttacaat tgtggttggc tcaatatata atatatggaa ggcattcaga agcatctatg     2640
attggaaaat ggaattctgc ggatgattta gaaatgtttt taaaagattt taaacaacat     2700
tcgcttcgca atccgattgt agaacaggtg attacagaaa ctcttcgtgt ggtaaaagat     2760
atttggttaa aatatggaaa tggagcaaaa gattttttca atgaaattca tattgagttg     2820
ggaagagaaa tgaagcttcc tgcgggtgat cgaaaaaaac tcacgaatca aattaccgaa     2880
aacgaaaaca ccaatctccg catcaaagct ctattggcag aaatgatgaa tgatcattca     2940
gtagaaaatg ttcgtccgtt ttcgcctatg caacaggaaa ttttgaaaat ctatgaagac     3000
ggcgttttaa attcaggtat tgagattgaa gatgaatatt tgaaaataag caaaacggca     3060
cagccttctt cttcagattt aaaaagatat aaactttggc tggaacaaaa atataaatca     3120
ccttataccg ggcaaattat tccattaaat aaattattca caccggaata cgaaattgaa     3180
cacattattc cgcaaagccg atattttgat gacagtttta gcaataaagt aatttgcgag     3240
tcggcggtta ataaattgaa agataattat atcggacttg gatttattaa gcagtttgga     3300
ggaactatta ttgagcttgg tttcgggaaa agtgtaaagg tatttaatat agaagagtat     3360
gaagattttg taaagaaaca ttatgcaaac aatagaggca aaagaaacaa gcttttgatg     3420
gaagatattc ctggaaaaat gattgaacgg caattgaacg atacccgcta tatcagtaaa     3480
tatgtttccg gaattctttc caatattgtt cgggtagaag acggttcaga cgaaggggtt     3540
aattctaaaa acatcgttcc gggaaatgga aaaatcacta cccaactgaa acaagattgg     3600
gggttgaatg atgtttggaa tgatataatt ttaccacgtt ttgaaagaat gaatcaactt     3660
actaattcaa aagattttac cgcctggaat gaaaatcatc aaaagttttt acctaccgtt     3720
ccaattgagt tttccaaagg attttcaaag aaaagaattg accatcgtca tcatgcttta     3780
gatgctttgg tgattgcctg tgccacaaaa gatcacgtga atttattaaa taatcaatcg     3840
gcaaaatcgg ataccaaacg atacgatttg aaaaagaaat tgatgaagtt tgaaaaagta     3900
gtttattatc atacgcaaac aggggagaaa atagaaaggg aaataccgaa acaattttta     3960
aaaccgtggg aaaactttac agttgacgca aaacataatc tggaatctat tattgtaagt     4020
tttaagcaaa accttcgtgt tattaataaa gcaactaatt attacgaaaa gtatgttgaa     4080
aaagacggta caaaaaataa ggaaagagta gagcagaccg gaacaaactg ggcgattaga     4140
aagccaatgc ataaggatac ggtttccgga aaagtagatt taccttgggt gaaagttcca     4200
aaaggaaaaa ttttaacagc aacgaggaaa agccttgata tttcatttga tttaaaatca     4260
atagcatcta ttactgatac agggattcag aaaattctca gaaattatct gaaattcaaa     4320
ggcagtccgg aacttgcatt ttctccagaa ggaatcgaag atctgaataa gaatattgag     4380
aagtacaatg atggaaaatc tcatcaaccg atcaataaag taagagtttt tgaactggga     4440
agtaaatttc aggtaggaca aaccggaaat aaaaaagata aatatgtaga agctgcaaaa     4500
ggaaccaatc tgttttttgc tgtttatgaa aatgaaaata gaaacagaag ttatgaaacc     4560
attcctttga atgaggttat agaaagacaa aagcaaggtt tatctgtggt tgacttaaaa     4620
ggaacaattg atttttttct ttgcccgaat gatttagttt atattccttc agaagatgaa     4680
cttgaaaata gtagcaacat tgacttcaaa aattttaaag aagaacaaaa caaaaaaatt     4740
tataaagtag ttagttttag tggaagtcag ttgtttttta taagacagga aattgccata     4800
tcaattgtaa ataaagcaga attttccacc ttgaataaaa tggagcgtag tattgatggg     4860
ttaatgatta aggaaaattg tatcaaatta aaagtagacc gtttgggaaa tatttctaaa     4920
gcatagtatt atgatcaccc gctccatcta catcggcaat cccgcttatc tcaaactcaa     4980
agatgagcag atgaaaatcc tctgtccgga taccaaaacg gaaaagggga gtgttcctgt     5040
ggaagatttg ggattactca tgctggatca ttatcagatt accatttcgc acaatttgat     5100
tcagaaaatg atgggaaata atgtggtgat cattagttgt gatgcacatc atttacccca     5160
cggaattatg cttccgctgt atggtcatac tgaacattcc gacagggtaa aagatcagct     5220
ggaagcaagt gaaccgctga aaaaacagct ttggaaacaa acggtggaat gtaaaattga     5280
aaaccagaaa aatgttctga tgaaactggg aaactattat gagcctatga ttcaatatca     5340
aaaaaatgta ctgtccggag atacaaccaa tatggaaggt attgcagctc agcattactg     5400
gaagtatcta atcagcctgg attttttaag acagcgtttt ggagattctc ccaatcagtt     5460
tttcaatttc ggttatgctg ttctcagaag tattgtggca agagccattg ttgagacggg     5520
actgctgccc gttcttggta tttttcataa aaataaatac aatccgtatt gccttgcgga     5580
tgatttaatg gaaccttacc gtccgtttgt tgatttactg gtgatgcagt ggctgaagat     5640
tcatcctgat acagaagaac tgtcgaaaga atttaaggct catattcttc agattgcaac     5700
caaagacgtg cgtattgatg acaaaacgag accattgctg gttgcggtaa aaactacggc     5760
ttcgtcgctt tacaaatgtt atataggaga aaagcggctg atctcttatc ctcaactgtt     5820
atgaattccg aaaggtttaa tgcataccga attatgtggg ttttagtatt atatgatctc     5880
ccgactgaga ccaaagctaa tatgaaagat gcgaaccgct tccggaaagg acttattgat     5940
gatggtttta ccctgtttca gttctctatg tatgtacgtc attgtccgag ccgcgaaaat     6000
gctgaagttc atattaaaag agtgaaattc atgcttccaa aagccgggaa agttgctatt     6060
atgtgcatta cagacaaaca attcggggat attgaaattt tctttgccag aaataaagaa     6120
gagcctcctc caacctttca gcaactcgaa ttattttaaa ttgcaaattc taattataaa     6180
aataatctac tgattttcag tagattattt tttgaggttg tgactaatca cgaagataat     6240
aaattttgaa agcaattcac aacgataaag gacacgtaca tgtaggtgat gtggttgtga     6300
ctaatcacga agataataaa ttttgaaagc aattcacaac ttacgtttac gtacggggaa     6360
gattcgttac gttgtgacta atcacgaaga taataaattt tgaaagcaat tcacaacaag     6420
atgcagcgat tattcttaaa gaaatgggtt gtgactaatc acgaagataa taaattttga     6480
aagcaattca caactactat tcgtagacgt gcgtgggaac atgagttgtg actaatcacg     6540
aagataataa attttgaaag caattcacaa ctcagagagt tgagaacatg tataataaat     6600
cgttgtgact aatcacgaag ataataaatt ttgaaagcaa ttcacaactc ttatgtagct     6660
aatcgtaaac agcaaactgt tgtgactaat cacgaagata ataaattttg aaagcaattc     6720
acaacattat ttctttatgt atgcacagac cgccggttgt gactaatcac gaagataata     6780
aattttgaaa gcaattcaca actataggaa tcatcaggag ccaatgtaaa aagttgtgac     6840
taatcacgaa gataataaat tttgaaagca attcacaacc atcacccttt catgaaatgc     6900
taatataatg ttgtgactaa tcacgaagat agtaaatttt ttatttttgc cttgaaacag     6960
tattcctgaa attttaaatg tataaggttc aggctgtttt gattctcaat acagatggaa     7020
tctataccgc aattgggaag tatgattgca aataattgaa gattttcaca tttcttgata     7080
tatgataaga tcatacaaat ctggtttttc tatttttgta cccgaaaaca acaaaatttc     7140
aataaacatt tttaaaacag ttcaatatga aaaaaattag cgtaattgca ttagtaggag     7200
taggattgct tttggcatca tgtgataaag gaaaaacagc agaaactgca gctaccgctc     7260
aggaacaaac cgtagcagaa agcaaaggtg aaacactggc agta                      7304

<210>  13
<211>  8221
<212>  DNA
<213>  Artificial sequence

<220>
<223>  CRISPR-Cas Locus 18

<400>  13
tgtgctgcga taatctggat gataagatgg aatgtattta atgtatccaa actgctgaag       60
ttgcttaaaa tatttatgat aactggttat tgtagtgata tgcgaaaact ccataagctt      120
gctcctgctc actctgataa tccatttttc attttgcttg caagcaaggc gggcaattgc      180
agttaacaaa gcaatatgcc aaacattcaa ttttggatca ctttgaattt catcaaggaa      240
atcaaaccag tattgtatat cattcctttt cataatcaaa tagatgttga aggtcttcac      300
aattgtaata atacgagccc aataatttct tgaatcgaat tttgccagtg atcctgaggt      360
tttgtaatgt cgaagcagaa atattcagtt ttctgcgaat taccttactc cgcatccagc      420
caaattcttc atcctctctt gaattagcta gcttagattt tagtaggttc tcaatatccg      480
aaactattag gtttctcaat gctgttaaat catttttcgt tattgtatcc atttttataa      540
attttgattt aattcaaaat ttaaactttg gacttacaga tatcctaaaa gaggaagtca      600
caggcataat ttttctttgt atttcttatt gcctgtgcag gaaatttaga aaagtgagct      660
ttaagtagtc atggaagaac aattctcgaa ccattttgtt gaagatttaa ataatcttaa      720
aggtttgatg tattaaagat gataattcta ataaaaatgc cccgaaggta gtcgaggcgc      780
taaatgtttt cacaacggaa taatccttat tgtgaattgc tttcaaaatt attgatacaa      840
atataaaaga aaaaaaataa ctgtatttat gggaatccat aatttgaata ttttttttat      900
tactattttt atgtggtatc aaaattaata gcgatgaaaa atatacttgg actggacttg      960
ggaacaaact ctattgggtg ggctttagta aaacaggatt ttgaaaacaa acaaggtgaa     1020
attcttggaa tggggaccag gataattccg atgtctcaag atattttggg cgattttggt     1080
aaagggaatt ctgtttcgca aactgcggaa cgtacaaaat acagaagtgt aagaagatta     1140
cgtgaacgat ttcttctacg aagggagagg cttcacaggg ttttaaacat tttgaattcc     1200
cttccagaac actatgcttc acagattgat tttgaaaaac gatttgggaa gttcaaagtt     1260
gaaactgaac caaaattggc ctggaaaaat attgaaggac atttttcatt tctgttccaa     1320
aactctttca acgagatgct tgaagatttt aaaacgaacg gacaggattt aaaaataccg     1380
tacgactgga cgatttatta tctccgtaaa aaggcacttt ctcaaaaaat tgaaaaagag     1440
gagttggcct ggattctttt gaattttaac caaaaacgtg gatattatca attgcgtggg     1500
gaagaagagg aagaaaatcc taataaaatt gttgaatttt attctttaaa agttgtggat     1560
gttctagcag atgagccaca aaaaagcaaa tcagatatat ggtattcttt ggttttagaa     1620
aatggatgga tttacagaag ggcaagtaaa atatcgttgt ttgattggaa agataaaaca     1680
agagatttta ttgtaacaac tgatttgaat gatgatggaa gtgttaaaac agacaaagac     1740
ggaaatgaaa aaagaagttt ccgggcaccg ggtgagaacg attggacttt ggtaaagaag     1800
aaaacagagc aggaaatcga gcagtctcat aaaaccgttg gaatatatat ttacgaaact     1860
ctccttaata atcccaaaca aaaaatcaaa gggaaactag ttcgtacgat tgaaagaaaa     1920
ttctataaag aagaactcag gcagatatta gaaaagcaaa agcagttcca tcaggaatta     1980
caaaatgatg atttatataa ttgttgtatt cgcgagttgt acagaaataa tgaagcccat     2040
caactgactt taagtaaaaa agattttgta catcttttta tggaggatat tgttttctac     2100
caaagaccgt tgagaagcca gaagtcttct atttccaact gtactttgga attcagaaaa     2160
tacaaagatg aaaatggagc agaacataca caatatttaa aagccattcc aaaatcgaat     2220
ccatattatc aggagtttcg tctctggcaa tggattttta atcttaatct atataaaaaa     2280
gataatgatg aaaacgttat caaagaattt ttaaccacta cccaggatat cgaaaatctg     2340
tttgagtttt taaataacag aaaagagatt gatcaaaaag ctctattgaa acattttaag     2400
ctcaatgaga aaacacatcg ttggaatttt gtagaggata aaaaataccc ctgcaatgaa     2460
acgaagacga tgatttcaac tcgattggaa aaagtagaaa atatttccga tgattttctg     2520
accagggaaa tcgaacaaca gatttggcat attatctatt ctgtcaatga taaaatagaa     2580
tacgaaaaag ccttaaaaac ctttgcatca aaacatcatc tagacgaaag ttcttttttc     2640
gaggctttca gaaaatttcc accatttaaa agcgaatatg gttcctattc ggaaaaagca     2700
attaagaaat tgttgcctat aatgcgattg ggcaaatatt gggattatgc caatattgat     2760
cagtcttcaa aagacaggat taagaagatc attaatggag aatatgatga aaatataaaa     2820
gataaggtaa gagaaaaggc agtccatctt acgaatgaaa atgatttcca gggtttacaa     2880
ttgtggctgg ctcaatatat tgtatatgga agacattcgg aagcatcaat aacagcgaaa     2940
tggaattcag ctgatgattt ggaagaattt ttaaaagatt ttaaacacca ctcgcttcgc     3000
aatccaattg tagagcaggt cattactgag actttacgtg ttgtgaaaga tatttggcta     3060
aaatacggaa aaggagcaaa agacttcttc aatgaaattc atatagagtt gggaagggaa     3120
atgaaacttc cggctgaaga tagaaagaaa cttacgagcc aaattattga aaatgaaaat     3180
acgaatctcc gcatcaaagc tctattagct gaaatgatga atgatcatgc tgtagaaaat     3240
gttcgtccgt tttcacccca gcaacaagaa attctgaaaa tttatgagga cggtgtttta     3300
aattcaggca ttgaaattga agatgaatat ttaaaaataa gcaaaacggc gcaaccttct     3360
ccttcagatt taaaacggta taaactttgg ctggaacaga aatacaaatc gccttatacc     3420
gggcaaatga ttccactaaa taaattgttt acgccagaat atgaaattga acatattatc     3480
ccacaaagtc gatactttga tgatagtttt agtaataaaa ttatttgtga atcggcagtt     3540
aacaaattga aggataatta tatcggactt ggatttatta agcagtttgg aggaactatt     3600
attgaacttg gtttgggtaa aagcgtgaag gtttttgata ttgatcaata cgaagatttt     3660
gttaagaagc actacgccaa taaccgaagt aaaagaaata aacttctttt agaagatatt     3720
cctgaaaaaa tgattgaacg tcagatcaat gatactcgtt atatcagtaa atatatttcc     3780
ggtatacttt ctaatattgt tcgcttagaa gatggttcgg atgaaggagt aaattctaaa     3840
aacattgttc ccggaaatgg aaaaattact acccaattga aaaaggactg ggggttgaat     3900
gatgtttgga atgacttgat tttaccccgt tttaaaagaa tgaatcagtt gaccaattcg     3960
acggatttta ccgcctggaa cgaaaatttt caaaagtttt tgccgaccgt tccaattgag     4020
tattcgaaag gtttttctaa aaaaaggatc gaccatcgtc atcatgctct agacgctttg     4080
gtaattgctt gtgctacaaa ggatcacgta aatttattaa ataatcaatc ggcaaaatcg     4140
gaaaccaaac gctatgattt gaaaaagaaa ttaatgaagt ttgaaagagt tgtttatttc     4200
catacgcaaa caggggagaa gatcgaaaga gaagtgccaa aacaattttt aaaaccctgg     4260
aaaaatttta ctgttgatgc tatgcataat ttggaaacgg ttattgtaag ttttaaacaa     4320
aaccttaggg tcattaataa agcaacgaat tattacgaaa aatatgtaga gaaagatggt     4380
gtaagaaata agacaagaat aaagcaaaag ggaataaatt gggcgattag aaaaccaatg     4440
cataaagata cggtttccgg taaagtagat ttaccttggg taaaagtccc aaaaggaaaa     4500
attttaacag caacaaggaa aagccttgac gcttcattcg atttaaaatc aataggctcc     4560
attactgata cagggattca aaaaattctc aaaaattatt taatgcataa agacggaaat     4620
acggaattgg ctttttcacc cgaaggaatt gaagatttga ataaaagtat tgagaagtat     4680
aatgatggta aacctcatca gcccatcaac aaagtaaggg tttttgaact gggtagtaaa     4740
tttcaggtag gacaagccgg aaataaaaaa gataaatacg tagaagccgc aaaaggaacc     4800
aatttgtttt ttggagtgta cgaagataaa aacggcaaga gaagctatga aaccattcct     4860
ttgaatgagg tgattgaaag gcaaaagcaa ggtttacctg tggttgactt aagaagtaca     4920
aatgatttct atttatgccc gaatgatttg gtttatattc tatctgatga tgagcggggt     4980
aatatgacaa atatcgattt tgaaagcctt tctgatgaac aagttaaaag gatatataaa     5040
tttgttagtt gtacaggagg tgagggacat tttattcctt acgcaaatgc gacagaaata     5100
ataaaaaatg aaaatggtac aaatagtaaa agtgagagaa tgcagaattt ctatgatggg     5160
agttgtatgt ttgataaaaa cgccaagccc attatgataa aagaaaactg tgtaaaactt     5220
aaagtcgacc gtttagggaa cattgcaaag atataattat gattacccgt tcaatctaca     5280
tcggtaatcc cgcttatctt aagctcaaag atgagcagct gaaaatcctc tgtccagaaa     5340
ccaaaatgga aaaggggagt gttcctgtgg aagatttggg tttgcttatg ctggatcatt     5400
atcagattac catttcgcat aatttgattc agaagatgat gggaaataat gtggtggtca     5460
ttagttgtga tgcgcatcat ttacctctcg gaattatgct tccactgtat ggtcatactg     5520
aacattctga ccgggtaaaa gatcagcttg aagccagtga accgctgaaa aagcaacttt     5580
ggaaacagac cgtggaatgt aagatcgaaa atcagaaaaa tgttctgatg aagttgggaa     5640
actattatga accaatggtt gaataccaaa caaatgtaaa gtctggggat ttaagcaata     5700
tggaaggtat tgcagctcag cattattgga aatatctgat cagccttgat tttttgagac     5760
agcgtttcgg agaatcaccc aatcagttct ttaatttcgg gtatgcggtt ctcagaagta     5820
ttgttgcaag ggctattgtt gaaacaggat tattgcccgt attgggaatt tttcataaaa     5880
ataaatataa tccttactgc cttgccgatg atctgatgga accttatcgt ccgtttattg     5940
atttactagt aatgcagtgg ctgaaaattt atcctgatgc agaagaactg gcgaaagaat     6000
ttaaggctca tattctgcag attgcaacca aagatgtgcg tattgatgat aaaacaaggc     6060
cattgctggt tgctgtaaaa atgacggctt cgtcgcttta caaatgctat acaggagaaa     6120
aaagactgat ttcttatcct gaactgttat gaacgccgaa aggtttaacg cataccggat     6180
tatgtgggtt ttagtattat atgatctccc gactgagacc aaagcgaata tgaaagatgc     6240
taaccgcttt cggaaagcgc tcattgatga tggtttcacc ttgtttcagt tctcaatgta     6300
tgtacgccat tgtccgagcc gggaaaatgc tgaggttcat attaaaagag ttaaatttat     6360
acttccaaaa gccgggaaag tggccattat gtgtatcacg gacaaacaat ttggagatat     6420
tgaaatcttc tttgccagga ataaagaaga gccacctcca acctttcagc agcttgaatt     6480
attctaaatt ttaaattcta aatataaaaa taatctactg aaaaccagta gattattttt     6540
tgaggctgtg actaatcacg aagataataa tttttgaaag caattcacaa cattccgctt     6600
aatccatttt taaatgactc agctgtgact aatcacgaag ataataattt ttgaaagcaa     6660
ttcacaacac atctttcttg tgtcaattgc accagttggc tgtgactaat cacgaagata     6720
ataatttttg aaagcaattc acaacaacca aagctactgc agttctaaga acatcgctgt     6780
gactaatcac gaagataata atttttgaaa gcaattcaca accgtaagac tgattagtac     6840
tcattgcaat tcgctgtgac taatcacgaa gataataatt tttgaaagca attcacaaca     6900
cgtattacca caatggaaat ttgaaaaatg ctgtgactaa tcacgaagat aataattttt     6960
gaaagcaatt cacaactgtc ccaagcatgg tttctcctaa ttttttgctg tgactaatca     7020
cgaagataat aatttttgaa agcaattcac aacagcatag agcattgtct aaatggaact     7080
ttagctgtga ctaatcacga agataataat ttttgaaagc aattcacaac cagcatcagc     7140
attatctgga ggattctctg gctgtgacta atcacgaaga taataatttt tgaaagcaat     7200
tcacaactaa caggacctat tggtttggtt acagttggct gtgactaatc acgaagataa     7260
taatttttga aagcaattca caacaaggac acattcctaa ctataatcca cagggctgtg     7320
actaatcacg aagataataa tttttgaaag caattcacaa ctgtctgata tgcttactac     7380
ttcacctctt agctgtgact aatcacgaag ataataattt ttgaaagcaa ttcacaacta     7440
ggtcctgaag catcaaatcc ggcattcgct gtgactaatc acgaagataa taatttttga     7500
aagcaattca caacgcgtat gaattataga catacatttc attcgctgtg actaatcacg     7560
aagataataa tttttgaaag caattcacaa cttgcatagt ttgcaggaaa ctaagtcttt     7620
agctgtgact aatcacgaag ataataattt ttgaaagcaa ttcacatgaa ttagtcaata     7680
cttaatctga cagttataat caaattaaat aactttaaaa cagattaagt attatgacaa     7740
cacaacaaaa aatcatcaaa aacaagttag gcgtacttga attagcacaa catttaggaa     7800
atgtatcgaa agcttgtaaa gtaatgggct attcccgaga cagtttttat cgattcaaag     7860
aactgtatga gcaaggaggt gaattagcat tacaggaaat ctccagaaga aagccagtat     7920
taaagaatcg tgtagatgaa gtcattgaaa aggctgttgt tgatatagct attgaaaacc     7980
ctgctttggg gcagcttaga gtaagtaatg aacttaaaaa gaaaggtttc attgtatcac     8040
caggtggagt cagaagtatt tggttaagac acgacctaca tacgtttaaa ctaagattaa     8100
aagccctaga agccaaatcc gctcaagatg gtgtagtcct tactgaatct caactttcag     8160
cactagaaag ggctaaggaa gagaaaaaag ctcatggaga aattgaaact catcatcctg     8220
g                                                                     8221

<210>  14
<211>  8221
<212>  DNA
<213>  Artificial sequence

<220>
<223>  CRISPR-Cas Locus 19

<400>  14
tatcagggct ctcatcctca ttattgccta tccatacatt tttaccgtca ttggctaaaa       60
aaatagtaca ggcatttatt ggaatgaaag tacctgctat caaaagctag atatatatta      120
ttttggtttt cattacttta aagataattt tttttaataa atgcttgaca atcttgttgt      180
gattttttat aataaaagaa gctgattacc cattttaaaa ttttagaaag tagaataaaa      240
aacaaaaacc atccttaaaa aaggatggtt tgtagtcatg aaagaacaat tctcgaacca      300
ttttgttgag gatttaaata agcttaaacg tttgatgtat taaagatgat aattctaata      360
aaaatgcccc gaaggtagtc gaggcgctaa atgttttcac aacggaataa tccttattgt      420
gaattgcttt caaaattatt gatacaaata taaaagaaaa aaattaactg tatttatggg      480
aatccataat ttgaatattt tttttattac tatttttatg tggtatcaaa ttaatagcga      540
tgaaaaatat acttggactg gacttgggaa caaactctat tgggtgggcg ttggtaaaac      600
aggattttga aaacaaacaa ggtgaaattc ttggaatggg agtcaggata attccgatgt      660
ctcaagatat tttgggcgat tttggtaaag ggaattctgt ttcgcaaacc gcggaacgta      720
caaaatatag aagtgtgaga cgattacgtg aacgatttct tctacgaagg gagaggcttc      780
acagggtttt aaatattttg aatttccttc cagaacacta tgcttcacag attgattttg      840
aaaaacgatt tgggaagttc aaagttgaaa ctgaaccaaa attggcctgg aaaaatattg      900
aaggacagtt ttcatttctg ttccaaaact ctttcaacga gatgcttgaa gattttaaag      960
cgaacggtca ggatttaaga ataccgtacg actggacgat ttattatctt cgtaaaaaag     1020
cactttatca aaaaattgaa aaagaggagc tggcctggat tcttttgaat tttaaccaaa     1080
aacgtggata ttatcaattg cgtggggaag aagaggaaga aaatcctaat aaacttgttg     1140
aattttattc tttaaaagtt gtagatgttc ttgcagatga gccgcaaaaa agcaaatcag     1200
atatttggta ttctttggtt ttagaaaatg gatggattta cagaagggca agcaaaatat     1260
tgttgtttga ttggaaagat aaaacaagag attttattgt aacaactgat ttgaatgatg     1320
atggaagtgt taaaacagac aaagaaggaa atgaaaaaag aagtttcagg gcaccgggtg     1380
agaacgattg gactttggta aagaagaaaa ccgagcagaa aatcgagcag tctcataaaa     1440
ccgttggaat gtatatatac gaaacgctac ttgctaatcc taaacaaaaa atcaaaggaa     1500
aattagttcg tacgattgaa agaaaatttt acaaagaaga gcttagacag atattagaga     1560
agcaaaagga gtttcatcag gaattacaaa atgatgactt atataatgat tgtattcgtg     1620
agttgtacag aaacaatgaa gctcaccaac tgactttaag caaaaaagat tttatacatc     1680
tttttataaa ggatattgtt ttctaccaaa gaccgttgag aagccagaag tcttctattt     1740
tcaactgtac tttggaattc agaaaataca aagatgaaaa tggagcagaa catacgcaat     1800
atttaaaagc aattccaaaa tcgaatccat attatcagga atttcgtctt tggcaatgga     1860
tttttaatct taacctatat aaaaaagata atgatgaaaa cgttatcaaa gaatttttaa     1920
ccactaccca agatgtcgaa aatctgtttg agtttttaaa caacagaaaa gaagttgatc     1980
aaaaaacttt attgaaacat tttaagctca atgagaaaac acatcgctgg aattttgtag     2040
aggataaaaa atacccctgc aacgaaacaa agacgatgat ttcaacccga ttgcagaaag     2100
tagaaaatat ttccggggat tttctgacga gggaaatcga acaaaagatt tggcatatta     2160
tatattctgt caatgataaa attgaatacg aaaaagcctt aaaatccttt gcgttaaaac     2220
atcaacttga caaaagttct tttttcgagg ctttcagaaa atttccacca tttaaaagcg     2280
aatatggttc cttttcggaa aaagcaatta agaaattgtt gcctttaatg cgattgggta     2340
agtattggga ttatgccaat attgataagt tttcaaaaga caggattcag aaaatcatta     2400
atggagaata tgatgaaaat ataaaagata gggtaagaga aaaggcggtc catcttagga     2460
gtgaagatga tttccagggt ttacaattgt ggctggccca atatattgta tatggaagac     2520
attcggaagc atcaataaca gggaaatgga attcagctga tgacttggaa gaatttttga     2580
aagattttaa acaccacttg cttcgcaatc caattgtaga gcaggtcatt acagaaactt     2640
tacgtgttgt aaaagatatt tggctaaaat atggaaaagg agcaaaagat ttcttcaatg     2700
aaattcatat agagttggga agggaaatga aacttccagc tgacgataga aagaaactca     2760
caaaccagat tactgaaaac gaaaatacga atctccgcat taaagctcta ttaacagaaa     2820
tgatgaatga tcatgctgta gaaaatgttc gtccgttttc gccccagcaa caagaaattc     2880
tgaaaattta tgaggacggc gttttaaatt caggcattga aattgaagat gaatatttaa     2940
aaataagcaa aacggcgcaa ccttttcctt cagatttaaa acggtataaa ctttggctgg     3000
aacagaaata caaatcgcct tatactgggc aaattattcc attaaataaa ttgtttacac     3060
cagaatatga aattgaacac attattccac aaagccgata ctttgatgac agttttagta     3120
ataaaattat ttgtgaatcg gcggttaaca aattgaaaga taattatatc ggacttggat     3180
ttattaagca gtttggagga actattattg aacttggttt cgggaaaagc gtaaaggttt     3240
ttgatattga tgaatatgaa gattttgtca agaagcacta cgccaataac cgaagtaaaa     3300
gaaataagct tctcttagaa gatattcctg aaaaaatgat tgaacgtcag atcaatgata     3360
ctcgttatat cagtaaatat atttccggta tactttctaa tattgttcgc ttagaagatg     3420
gttcggatga aggagtaaat tctaaaaaca ttgttcccgg aaatggaaaa attactaccc     3480
aattgaaaaa agactggggg ttaaatgatg tttggaatga cttgatttta ccccgtttta     3540
aaagaatgaa tcagctgacc aattcgacag attttaccgc ctggaacgaa aattttcaaa     3600
agtttttgcc gaccgttcca attgaatatt ccaaaggttt ttctaaaaaa agaatcgacc     3660
atcgtcatca tgctttagac gctttggtaa ttgcttgtgc tacaaaggac cacgtaaatt     3720
tattaaataa tcaatcggca aaatcggaaa ccaaacgcta cgatttgaaa aagaaattaa     3780
tgaagtttga aagagttgtt tatctccata tgcaaacagg ggagaaaatc gaaagagaag     3840
tgccaaaaca atttttaaaa ccttgggaaa attttactgt agatgttaag tataatttgg     3900
acatggttat tgtaagtttt aagcaaaacc ttagggtcat taataaagca acgaattatt     3960
acgaaaaata tgtagagaag gatggtgcaa gaaataagac aagagtagag caaaagggaa     4020
taaattgggc tattagaaaa ccaatgcata aagatacggt ttccggtaaa gtagatttac     4080
cttgggtaaa agttccaaaa ggaaaaattt taacagcgac gaggaaaagc cttgatgctt     4140
cattcgattt aaaatcaatt gcctccatta ctgatacagg gattcaaaaa attctcaaaa     4200
attatttaat gcttaaagat ggaaaccctg aattggcttt ttcacccgaa ggaattgaag     4260
atttgaataa aagtattgag aagtacaatg atggcaaacc tcatcaaccc atcaataaag     4320
taagggtttt tgaactgggt agtaaatttc agataggaca agccggaaat aaaaaagata     4380
aatacgtaga agccgcaaaa ggaaccaatt tgttttttgc agtgtacgaa gatgaaaacg     4440
gcaagagaag ctatgaaact attcctttga atgaggtgat tgaaaggcaa aagcacggtt     4500
tacctgtggt tgatttaaca agtacaaatg atttctattt atgcccgaat gatttggttt     4560
atattctatc tgatgatgag cgggataata tgacaaataa cgattttgaa aacctttctg     4620
acgaacaagt taaaaggata tacaaatttg ttagttgtac aggaggtgag gggcatttta     4680
ttccttacgc aagtgcgaca gaaataataa aaaatgaaaa cggtacaaat agtaaaagcg     4740
agagaataca gaatttctat gatggtagtt gtatgcttga taaaaacagc aagcccatta     4800
tgataaagga aaactgtgta aaacttaaag tcgaccgttt aggtaacatt tcaaagatat     4860
aattatgatt acccgttcaa tctacatcgg taatcccgct tatctcaagc tgaaagatga     4920
acagatgaaa attctttgtc cggaaaccaa aacggaaaag gggagtgttc ctgtggaaga     4980
tttgggctta ctgatgttgg atcattatca gattactatt tcgcataatc tcattcagaa     5040
aatgatggga aataacgtgg tggtcatcag ttgtgacgct catcatttgc cccatggaat     5100
aatgcttcca ctgtatggtc atactgaaca ttccgacagg gtaaaagatc agttggaagc     5160
aagtgaacca ttgaaaaaac agctttggaa gcaaaccgtg gaatgcaaaa ttgaaaatca     5220
gaaaaatgtt ctgatgaaat tggaaaacta ttatgaacca atggttgaat accaaagaaa     5280
tgtaaagtct ggggatttaa ccaatatgga aggtattgca gctcagcatt actggaaata     5340
tctgatcagc cttgattttt tgagacagcg tttcggagaa tcacccaatc agttctttaa     5400
tttcgggtat gcggttctta gaagtattgt cgccagggct attgttgaaa caggattatt     5460
gcctgtattg gggatttttc ataaaaataa atataatcct tactgtcttg ccgatgatat     5520
aatggaacct tatcgtccgt ttgttgattt actcgtgatg caatggctga aaattcatcc     5580
taataccgaa gaactgtcga aagaatttag ggctcatatt cttcagattg caaccaaaga     5640
tgtacatatt gatgacaaaa caagaccgtt gcttgttgct gtaaaaatga cggcttcatc     5700
gctttacaaa tgctacacag gagaaaaaag attgatctct tatcctgaac tgttatgaac     5760
gccgaaaggt ttaacgcata ccggattatg tgggttttag tattatatga tctcccgact     5820
gagaccaaag cgaatatgaa agatgctaat cgctttcgga aggcgctcat tgatgatggt     5880
ttcaccttgt ttcagttctc aatgtatgta cgccattgtc cgagccggga aaatgctgag     5940
gttcatatta aaagagttaa atttatgctt ccaaaagctg ggaaagttgc cattatgtgt     6000
atcacggaca aacaatttgg agatattgaa atcttttttg ccaggaataa agaagagcca     6060
cctccaacct ttcagcagct tgaattattc taaattttaa attctaaata taaaaataat     6120
ctactggttt tcagtagatt attttttgag gctgtgacta atcacgaaga taataatttt     6180
tgaaagcaat tcacaacttg ttcctgactg aattctatcg atccggtgct gtgactaatc     6240
acgaagataa taatttttga aagcaattca caacaatctc ttctagtggt atccactttt     6300
ttcagctgtg actaatcacg aagataataa tttttgaaag caattcacaa cgctaaactt     6360
cctatcaagc agatcagaac cgctgtgact aatcacgaag ataataattt ttgaaagcaa     6420
ttcacaacgt agaaaaatca tatcctgcag ttggttgggc tgtgactaat cacgaagata     6480
ataatttttg aaagcaattc acaacaaccg atattgatat cggttttttt gtgctgctgt     6540
gactaatcac gaagataata atttttgaaa gcaattcaca acgacagaaa agataatcct     6600
gctcagattg atggctgtga ctaatcacga agataataat ttttgaaagc aattcacaac     6660
taacaattaa aactactatg tcctccatct gctgtgacta atcacgaaga taataatttt     6720
tgaaagcaat tcacaactct tttcatcgtt attaaatttt attttaggct gtgactaatc     6780
acgaagataa taatttttga aagcaattca caacagaata tttcggtgga tcttttcctg     6840
gttggctgtg actaatcacg aagataataa tttttgaaag caattcacaa ctatcgtaaa     6900
cactacaaga tgcattctta tgctgtgact aatcacgaag ataataattt ttgaaagcaa     6960
ttcacaacgt atctttaccc tatggaaaac atggaagagc tgtgactaat cacgaagata     7020
ataatttttg aaagcaattc acaacttcat ctgctttaaa cagattataa cctttgctgt     7080
gactaatcac gaagataata atttttgaaa gcaattcaca actaactttc aatttaggca     7140
taataacaaa ttgctgtgac taatcacgaa gataataatt tttgaaagca attcacaaca     7200
gaaatttcaa taatggatac aatcctttag ctgtgactaa tcacgaagat aataattttt     7260
gaaagcaatt cacaactatc cttagcctta gcagaaagat cagctggctg tgactaatca     7320
cgaagataat aatttttgaa agcaattcac aacgaaattg gatatggtgc tgtaatgaat     7380
tttgctgtga ctaatcacga agataataat ttttgaaagc aattcacaac acatttgaga     7440
agacattaat ggctttgaag gctgtgacta atcacgaaga taataatttt tgaaagcaat     7500
tcacaactac tatccccaaa ttcatcatta gcagcccgct gtgactaatc acgaagataa     7560
taatttttga aagcaattca caacacctat cgttaaggga attagcgact gcacgctgtg     7620
actaatcacg aagataataa tttttgaaag caattcacaa ctttagttct aattgtaaat     7680
gcttcattat tgctgtgact aatcacgaag ataataattt ttgaaagcaa ttcacaacta     7740
cgactacggt gactcttatt catatcacgc tgtgactaat cacgaagata ataatttttg     7800
aaagcaattc acaacgcgac tgcatgatgg caaaacgaaa gcagagctgt gactaatcac     7860
gaagataata atttttgaaa gcaattcaca acagtatgga aaagagaata ccaatttatc     7920
aagctgtgac taatcacgaa gataataatt tttgaaagca attcacaact atcgaggaca     7980
cttgactttt ctgaagtggg ctgtgattaa tcactaagat aataaatttt gaaggcaatt     8040
cacaacatat aagataacaa tttaattata gagttttaag aagttcgcct tttagttgaa     8100
catatattca agcactacta aaaccataca agagatatta caaataaatt tcttaaaaat     8160
caattttcca caattaccta aagaagtaag gagtgcattc gcaatttttg aaaatagttc     8220
c                                                                     8221

<210>  15
<211>  6813
<212>  DNA
<213>  Artificial sequence

<220>
<223>  CRISPR-Cas Locus 20

<400>  15
aataaaaaag caacctgctg taaattagct ggttgctttt gtttggttgt agtcatgaaa       60
gaacaattct cgaaccattt tgttgaggat ttaaataagc ttaaacgttt gatgtattaa      120
agatgataat tcaaataaaa atgccccgaa ggtagtcgag gctctaaatg ttttcacaac      180
ggaataatcc ttattgtgaa ttgctttcaa aattattgat acaaatataa aagaaaaaaa      240
ttaactgtat ttatgggaat ccataatttg aatatttttt ttattactat ttttatgtgg      300
tatcaaatta atagcgatga aaaatatact tggactggac ttgggaacaa actctattgg      360
gtgggcgttg gtaaaacagg attttgaaaa caaacaaggt gaaattcttg gaatgggagc      420
caggataatt ccgatgtctc aagatatttt gggcgatttt ggtaaaggga attctgtttc      480
gcaaaccgcg gaacgtacaa aatatagaag tgtgagacga ttacgtgaac gatttcttct      540
acgaagggag aggcttcaca gggttttaaa tattttgaat ttccttccag aacactatgc      600
ttcacagatt gattttgaaa aacgatttgg gaagttcaaa gttgaaactg aaccaaaatt      660
ggcatggaaa aatattgaag gacagttttc atttctgttc caaaactctt tcaacgagat      720
gcttgaagat tttaaagcga acggtcagga tttaagaata ccgtacgact ggacgattta      780
ttatcttcgt aaaaaagcac tttatcaaaa aattgaaaaa gaggagctgg cctggattct      840
tttgaatttt aaccaaaaac gtggatatta tcaattgcgt ggggaagaag aggaagaaaa      900
tcctaataaa cttgttgaat tttattcttt aaaagttgta gatgttcttg cagatgagcc      960
gcaaaaaagc aaatcagata tttggtattc tttggtttta gaaaatggat ggatttacag     1020
aagggcaagc aaaatattgt tgtttgattg gaaagataaa acaagagatt ttattgtaac     1080
aactgatttg aatgatgatg gaagtgttaa aacagacaaa gaaggaaatg aaaaaagaag     1140
tttcagggca ccgggtgaga acgattggac tttggtaaag aagaaaaccg agcaggaaat     1200
cgagcagtct cataaaaccg ttggaatgta tatatacgaa acgctacttg ctaatcctaa     1260
acaaaaaatc aaaggaaaat tagttcgtac gattgaaaga aaattttaca aagaagagct     1320
tagacagata ttagagaagc aaaaggagtt tcatcaggaa ttacaaaatg atgacttata     1380
taatgattgt attcgtgagt tgtacagaaa caatgaagct caccaactga ctttaagcaa     1440
aaaagatttt atacatcttt ttataaagga tattgttttc taccaaagac cgttgagaag     1500
ccagaagtct tctatttcca actgtacttt ggaattcaga aaatacaaag atgaaaatag     1560
agcagaacat acgcaatatt taaaagcaat tccaaaatcg aatccatatt atcaggaatt     1620
tcgtctttgg caatggattt ttaatcttaa cctatataaa aaagataatg atgaaaacgt     1680
tatcaaagaa tttttaacca ctacccaaga tgtcgaaaat ctgtttgagt ttttaaacaa     1740
tagaaaagaa gttgatcaaa aaactttatt gaaacatttt aagctcaatg agaaaacaca     1800
tcgctggaat tttgtagagg ataaaaaata cccctgcaac gaaacaaaga cgatgatttc     1860
aacccgattg cagaaagtag aaaatatttc cggggatttt ctgacgaggg aaatcgaaca     1920
aaagatttgg catattatat attctgtcaa tgataaaatt gaatacgaaa aagccttaaa     1980
atcctttgcg ttaaaacatc aacttgacaa aagttctttt ttcgaggctt tcagaaaatt     2040
tccaccattt aaaagcgaat atggttcctt ttcggaaaaa gcaattaaga aattgttgcc     2100
tttaatgcga ttgggtaagt attgggatta tgccaatatt gataagtttt caaaagacag     2160
gattcagaaa atcattaatg gagaatatga tgaaaatata aaagataggg taagagaaaa     2220
ggcggtccat cttaggagtg aagatgattt ccagggttta caattgtggc tggcccaata     2280
tattgtatat ggaagacatt cggaagcatc aataacaggg aaatggaatt cagctgatga     2340
cttggaagaa tttttgaaag attttaaaca ccacttgctt cgcaatccaa ttgtagagca     2400
ggtcattaca gaaactttac gtgttgtaaa agatatttgg ctaaaatatg gaaaaggagc     2460
aaaagatttc ttcaatgaaa ttcatataga gttgggaagg gaaatgaaac ttccagctga     2520
cgatagaaag aaactcacaa accagattac tgaaaacgaa aatacgaatc tccgcattaa     2580
agctctatta acagaaatga tgaatgatca tgctgtagaa aatgttcgtc cgttttcgcc     2640
ccagcaacaa gaaattctga aaatttatga ggacggcgtt ttaaattcag gcattgaaat     2700
tgaagatgaa tatttaaaaa taagcaaaac ggcgcaacct tctccttcag atttaaaacg     2760
gtataaactt tggctggaac agaaatacaa atcgccttat actgggcaaa ttattccatt     2820
aaataaattg tttacaccag aatatgaaat tgaacacatt attccacaaa gccgatactt     2880
tgatgacagt tttagtaata aaattatttg tgaatcggcg gttaacaaat tgaaggataa     2940
ttatatcgga cttggattta ttaagcagtt tggaggaact attattgaac ttggtttcgg     3000
gaaaagcgta aaggtttttg atattgatga atatgaagat tttgtcaaga agcactacgc     3060
caataaccga agtaaaagaa ataagcttct cttagaagat attcctgaaa aaatgattga     3120
acgtcagatc aatgatactc gttatatcag taaatatatt tccggtatac tttctaatat     3180
tgttcgctta gaagatggtt cggatgaagg agtaaattct aaaaacattg ttcccggaaa     3240
tggaaaaatt actacccaat tgaaaaaaga ctgggggtta aatgatgttt ggaatgactt     3300
gattttaccc cgttttaaaa gaatgaatca gctgaccaat tcgacagatt ttaccgcctg     3360
gaacgaaaat tttcaaaagt ttttgccgac cgttccaatt gaatattcca aaggtttttc     3420
taaaaaaaga atcgaccatc gtcatcatgc tttagacgct ttggtaattg cttgtgctac     3480
aaaggaccac gtaaatttat taaataatca atcggcaaaa tcggaaacca aacgctacga     3540
tttgaaaaag aaattaatga agtttgaaag agttgtttat ctccatgtgc aaacagggga     3600
gaaaatcgaa agagaagtgc caaaacaatt tttaaaacct tgggaaaatt ttactgtaga     3660
tgttaagcat aatttggaca cggttattgt aagttttaag caaaacctta gggttattaa     3720
taaagcaacg aattattacg aaaaatatgt agagaaggat ggtgcaagaa ataagactag     3780
agtagagcaa aagggaataa attgggctat tagaaaacca atgcataaag atacggtttc     3840
cggtaaagta gatttacctt gggtaaaagt tccaaaagga aaaattttaa cagcgacgag     3900
gaaaagcctt gatgcttcat tcgatttaaa atcaattgcc tccattactg atacagggat     3960
tcaaaaaatt atcaaaaatt atttaatgct taaagatgga aaccctgaat tggctttttc     4020
acccgaagga attgaagatt tgaataaaag tattgagaag tacaatgatg gcaaacctca     4080
tcaacccatc aataaagtaa gggtttttga actgggtagt aaatttcaga taggacaagc     4140
cggaaataaa aaagataaat acgtagaagc cgcaaaagga accaatttgt tttttgcagt     4200
gtacgaagat gaaaacggca agagaagcta tgaaactatt cctttgaatg aggtgattga     4260
aaggcaaaag cacggtttac ctgtggttga tttaacaagt acaaatgatt tctatttatg     4320
cccgaatgat ttggtttata ttctatctga tgatgagcgg gataatatga caaataacga     4380
ttttgaaagc ctttctgacg aacaagttaa aaggatatac aaatttgtta gttgtacagg     4440
aggtgagggg cattttattc cttacgcaag tgcgacagaa ataataaaaa atgaaaacgg     4500
tacaaatagt aaaagcgaga gaatgcagaa tttctatgat ggtagttgta tgcttgataa     4560
aaacagcaag cccattatga taaaggaaaa ctgtgtaaaa cttaaagtcg accgtttagg     4620
taacatttca aagatataat tatgattacc cgttcaatct acatcggtaa tcccgcttat     4680
ctcaagctga aagatgaaca gatgaaaatt ctttgtccgg aaaccaaaac ggaaaagggg     4740
agtgttcctg tggaagattt gggcttactg atgttggatc attatcagat tactatttcg     4800
cataatctta ttcagaaaat gatgggaaat aacgtggtgg tcatcagttg tgacgctcat     4860
catttgcccc atggaataat gcttccactg tatggtcata ctgaacattc cgacagggta     4920
aaagatcagt tggaagcaag tgaaccattg aaaaaacagc tttggaagca aaccgtggaa     4980
tgcaaaattg aaaatcagaa aaatgttctg atgaaattgg aaaactatta tgaaccaatg     5040
gttgaatacc aaagaaatgt aaagtctggg gatttaacca atatggaagg tattgcagct     5100
cagcattact ggaaatatct gatcagcctt gattttttga gacagcgttt cggagaatca     5160
cccaatcagt tctttaattt cgggtatgcg gttcttagaa gtattgtcgc cagggctatt     5220
gttgaaacag gattattgcc tgtattgggg atttttcata aaaataaata taatccttac     5280
tgtcttgccg atgatataat ggaaccttat cgtccgtttg ttgatttact cgtgatgcaa     5340
tggctgaaaa ttcatcctaa taccgaagaa ctgtcgaaag aatttagggc tcatattctt     5400
cagattgcaa ccaaagatgt acatattgat gacaaaacaa gaccgttgct tgttgctgta     5460
aaaatgacgg cttcatcgct ttacaaatgc tacacaggag aaaaaagatt gatctcttat     5520
cctgaactgt tatgaacgcc gaaaggttta acgcataccg gattatgtgg gttttagtat     5580
tatatgatct cccgactgag accaaagcga atatgaaaga tgctaatcgc tttcggaagg     5640
cgctcattga tgatggtttc accttgtttc agttctcaat gtatgtacgc cattgtccga     5700
gccgggaaaa tgctgaggtt catattaaaa gagttaaatt tatgcttcca aaagctggga     5760
aagttgccat tatgtgtatc acggacaaac aatttggaga tattgaaatc ttttttgcca     5820
ggaataaaga agagccacct ccaacctttc agcagcttga attattctaa attttaaatt     5880
ctaaatataa aaataatcta ctggttttca gtagattatt ttttgagggc tgtgactaat     5940
cacgaagata ataatttttg aaagcaattc acaacagccc cagcgggttt agctccgcct     6000
ttcttgctgt gactaatcac gaagataata atttttgaaa gcaattcaca accaaataga     6060
ttattttcta tagacagctt cagctgtgac taatcacgaa gataataatt tttgaaagca     6120
attcacaaca atttccggat taaactaaag cttttcatcg ctgtgactaa tcacgaagat     6180
aataattttt gaaagcaatt cacaactaat taattattgc tgtgactaat cacgaagata     6240
ataatttttg aaagcaattc acaacgcttt gccacaggaa gtggatatcc atttagctgt     6300
gactaatcac gaagataata atttttgaaa gcaattcaca actagcaata aactgttttt     6360
gaagatctcc ctgctgtgac taatcacgaa gataataatt tttgaaagca attcacaacc     6420
tggtacttgg aaggggtacg ggaaaaacgg ctgtgactaa tcacgaagat aataattttt     6480
gaaagcaatt cacaacggtg aatacaacat gctttctaat gatcttgctg tgactaatca     6540
cgaagataat aatttttgaa agcaattcac aacatttttt cttttttcta tcactggaga     6600
cctgctgtga ctaatcacga agataataat ttttgaaagc aattcacaac ctatgaacct     6660
gtaaatacta agtgtgccag gctgtgacta atcacgaaga taataatttt tgaaagcaat     6720
tcacaacaaa taaaattaag gtactccctt tgccctcgct gtgactaatc acgaagataa     6780
taatttttga aagcaattca caacaaatat ata                                  6813

<210>  16
<211>  7929
<212>  DNA
<213>  Artificial sequence

<220>
<223>  CRISPR-Cas Locus 21

<400>  16
acagcagcag accatggagc agaagtgttt tttactaact tttcagacga tgacggattg       60
tatatagtaa tcggcattat ttcattgaaa tcgtcactga aatttcccat ccatgtagta      120
taagctctaa tgtaataaac atcttctttt aaatctgcgg gtaagctgat gcttccgctg      180
cctttaccat taatcagggg atagattttt ttgctgattt gttttttatt ttgatcgtac      240
aattcaacga aaacattggt agaaatcgtt gaagggctgt atccgtcaaa tacaaaagag      300
gtaaaccaaa gattttcacc ggcaacataa ttctttttac taagaagaag gtgtattttt      360
tcttgcggat agttttcctc aaatttttta agtgcttctt ctgctttgtt ctgagaaaaa      420
taaaatggag caataattag tgataatgca atcaatggct tttgaaacaa acagatattc      480
attatatggt tcgtgtttta atatatttca aaaatacatt tttttctatt gaaagagaga      540
taaatggtgc tattatttaa ataaaaatgc cccgcagata ggcgaggcgc taaatgtttt      600
cacaacggaa taatccttat tgtgaattgc tttcggatac aaatctaaaa ataatatttt      660
taatcagttt acggttttcc acatttatat gaattaaatt cttattaatt tagaaaactc      720
gattaaaata aataaccatg gcaaaaaata tacttggatt agatttagga accaactcga      780
ttggttgggc gttaatagaa gttgactaaa acaatattcc tatccggatt attgcaatgg      840
gttcacgtat aattccttta tcaacaagtg ataaagaaga atttcaaaga ggtttgtcaa      900
tcactaagaa tcaaagtaga acggtaagcc gtactcagag aaaagggtat gaccggaaac      960
aattgaagaa aagtaattta aagaaaattc taaataaata taatatcttc ctttcagaag     1020
aattattaaa acttccaatg cttgatttgt ggaaattgag aagtgattct gcaaacccaa     1080
atgaaaatat ttcgactgaa caattgggac gaattttata tatgttgaat caaaagcgtg     1140
gctataaatc tgcaagaagt gaagcaaatg ccgataaaaa agatacagat tatgttcagg     1200
cagtaaaagg gcgctacgca cagctgaaag aaagaaatca aacaatcgga caatattttc     1260
atgaagaatt gcataatgca aatgcaaaca attcttattt cagaataaaa gaagaagttt     1320
atccgagaga agcttatata gaagagtttg atacgattat taatgctcaa aaagataaac     1380
atgattttct tacagacgaa gtcgttcatc aattaagaaa tgaaatcatt tattttcaaa     1440
gaaaactaaa atctcaaaaa ggattgatca atatttgtga atttgaaggc tttgagaaaa     1500
cagtttttga caaggacaaa aacaaacaca aagtagtgtc tgtcggtccg aaagttgcgc     1560
cgaaaacatc tccattgttt cagctttgtc gtatttggga agttgtaaat acaattacct     1620
taaaaataaa gaatcctgaa ggaagcaaat ataaatgggg tgagaaaatt ccaaatttaa     1680
ttgagaaaga gattttagct gattatttac ttaaaaatga gagtttaagt tttacgaagc     1740
ttcttgaaat tttagaatta aataaaaatg atatttatgt aaataagcaa atattaaaag     1800
gtataaaagg caatgaaact tatgctgttc ttcagaatat tttaggagat aatgaacttt     1860
taaattttga tgtttcaatt attccatcca attacacttc aattttggtg gacaaaaaaa     1920
cgggagagat attggaagag agagcaggtc tcgaattaga tgcttcatta gaaaaagagc     1980
ctttatacca gctgtggcac accatttatt ccctaaaaga tttagatgaa tgcaaaaatg     2040
ctttaattaa aaggtttgga ttcgatgatg agattgccga aaagttgtct cgtatcaatt     2100
tcaacaaaca agcttttagc aataaatcga acaaatcgat gagaaaaatt cttccttttc     2160
tgatggaagg ctacgattat tctcaatctt gcagtttggc ggggtacaat cattctaatt     2220
cgttgacgaa agatgaaaga gaacagcagg taactttaaa cagattagaa cttcttcaaa     2280
aaaacagttt acgacagcct attgttgaga aaattctgaa tcagatgata aatgtggtga     2340
acgcaattct tgagcaatac ggaaaaccaa ctgaaattag agttgagctc gcacgagacc     2400
ttaagcaaag caaagacgag cgcaacgatg ccgatttaca aaattcaaaa aataaaaaac     2460
tcaatgaaga aattggtaaa cgattggctg aattgggact gcctgctacg aaacgatata     2520
ttcaaaaata taaattcatt tttccatcgc ttagcaaaaa tctaaaagat gctcgcgtta     2580
acaatcaatg tatttattgt ggagaaacat ttaatttaac ggaagcttta agtggtgatg     2640
cttttgatgt tgaccacatt gtcccgaaag ctttattgtt tgatgattca caaaccaata     2700
aagtattggt tcatagaaaa tgtaattcga caaaaaccaa tcaaactgcg tatgattaca     2760
ttgctacaaa aggtgacgaa caagttcgta tttattctga acgaattgat gattggttta     2820
aaagaggaat tatttcttac agtaaaatgc aaagattaaa ggtttcacat aaggaatatc     2880
ttgaaagaaa aaaaatagga aaagaaaccg aaactgataa gaagctttgg gaaaatttta     2940
tagacagaca gttgagagat actcaatata tttcccgaaa atcaagagag attctacaga     3000
aagtatgcaa caatgtaact acaacagaag gcggagttac agcaaaactt cgcaatttgt     3060
ggggttggga tgatgttttg atgaatttgc aaatgccaaa atataaagaa ttagggcaaa     3120
ctgtcatcaa agaatggaca agcgaccacg gaaaaagaaa acatcaaaaa gaagaaatag     3180
aaaattggac aaaaagagat gaccatcgtc atcacgccat tgatgctttg gtaattgcct     3240
gcacaagaca aggttttatt cagcggataa atactttgaa ttctagcgat actaaagatt     3300
taatgatgaa agaagttgaa aaagcaaaaa tcgaatttaa tgaaaagagt acccttttag     3360
aaaaatattt aaagactcaa aagccgttta ctacagaaca agtaatgaaa gaagctgata     3420
aaattttagt ttcatttaaa gcaggtaaaa aagtagcaac aataactaaa tttaaagcta     3480
caggaaaaaa taaagataca ggagtaattg ttccaagagg agcgttacat gaacaaaatg     3540
tttatggtaa gataaaagct attgaaaaag ataagtcttt aaagtatttg tttgaaaatt     3600
cagggaaaat tgtaaatcct aaaattaaaa atttagttga aataagactt tcggaaaatg     3660
aaaatagttc aaaaatggct ttatcaacat taaagaaaaa tcccattttc ctaaatgaag     3720
aaaaaactga tttactagaa aaggcatcat gttatgagta tgttactgtt agaaagtatc     3780
ctttgaacac aataaaagca agtcaggctg atgatattgt tgatgaaaga gtgaaatttt     3840
tagtgaaaga aagattggcc caatttggaa ataaagaaaa agaagctttt aaagatacac     3900
tttggttcaa cgaagaaaaa caaattccga ttattaccgt tcgtttattt gctcgtcctg     3960
atgctaataa tttacaggca atgaaaaagg atgaaaacgg taaagaaata ggatttgtag     4020
tgttgggcaa caatcatcat atcgccattt atgaggataa agacaacaag cttgtgcagc     4080
acagttgtac tttttggcat gcagtggaaa ggaaaaaata taacattcca ccagtaatta     4140
aaaattcctc agaaatttgg aatcaattat taaataaaga attcccagaa acttttttgg     4200
ataaattacc tgcggataat ctcgaattaa aatttagtat gcaacaaaat gaaatgttta     4260
ttctgggatt accacaagaa gaatttgaag aagcaataaa aaataatgat aaatctgttt     4320
tgagtaaaca catgtattta gtttggagta ttgctgacgg agattattgg tttagacatc     4380
atttagaaac aaaaaataca gagttaaaga aaatcaatgg tgcaaaagaa agcaaaagat     4440
ttttcagatt gcaaagtctt aaggctgtag aaaatttgac accaatcaag gtaagactga     4500
atcatttagg agaaataact aaaataggag aatactaacc catgataacc cgttacatct     4560
acatcggcaa tcccacctat ctgaaactca aagacaatca gatgaaaatc ctttgtccgg     4620
aaactaaaat cgaaaagggg agtgtgcctg tcgaagattt gggtttgctg atgttagacc     4680
attatcaaat cacgatttcc catcagctca ttcagaaaat gatgggaaat aatgttgtag     4740
ttgtaagttg cgattcccat catttgccac acggaattat gcttccattg tatggtcatt     4800
cggaacattc agatagggta aaagaccagt tagaagcaag tgaaccgctc aaaaagcaac     4860
tctggaaaca aactatcgaa tgtaaaattg agaaccaaaa agaagttctc cggcgattag     4920
gaaactatta cgaaccgatg cttgagtatc aaaacaatgt taaaagcggt gatattacca     4980
atatggaagg catcgccgca caacattact ggaaatatct catcagtttg gatttcctga     5040
gacagcgttt tggagattca cccaatcagt ttttcaattt cggttatgcc gttctaagaa     5100
gtattgtcgc aagagcaata gtcgaaacag gattgcttcc ggttctcgga attttccata     5160
aaaataaata caatccttat tgtcttgctg atgatttgat ggagccttac cgcccatttg     5220
tagatttgct agtcatgcaa tggcttgaaa tacatcccga aaccgaagaa ttaaccaaag     5280
agttcaaagc ccatatcctc caaattgcca caaaagatgt tcggattgat gacaaaacaa     5340
gacctttatt aatttctgta aaaacaactg caacctcgct ttataaatgc tacaccggcg     5400
aaaaaagaat gatttcctat ccagaattac agtaattttt ttatgggcag cttttccgcc     5460
ttccgctccc aatctttttt gcagacgatt tcacataaaa tagtatttga gagcaagcaa     5520
aaaaggattt ccgctcaagt cgggttgcaa ccattatacc gcaaaacaaa ccatgaaaaa     5580
tgaatgccga aaggtttaac gcttaccgaa ttatgtgggt tttagtatta tacgacttac     5640
caacggaaac caaagccaat atgaaagatg ccaaccgctt tcgtaaaggc ctaattgatg     5700
atggctttac attatttcaa ttttccatgt atgttcgcca ttgcccaagt cgcgaaaatg     5760
ctgaggtgca cattaagcgc acgaagttta atcttccaaa agcaggaaaa gtagccatca     5820
tgtgtattac cgataagcaa tttggcgaca ttgaaatatt ctttgccaga aataaagaag     5880
aaccgccacc caccttccaa caactcgaat tattctaaat tttaaatcct aaaaaacaac     5940
aaaacccatt gaataacaat gggttgaatt ttgaggttgt gttatatctc aaagatactc     6000
aaaaatgaaa gcaattcaca acattatcac gatgattttc aagcggtaaa agttgtgtta     6060
tatctcaaag atactcaaaa atgaaagcaa ttcacaactg tacaagctta cggagagata     6120
caagctttgt tgtgttatat ctcaaagata ctcaaaaatg aaagcaattc acaacttgta     6180
tatcgtgtgg cacaacaaaa aataagttgt gttatatctc aaagatactc aaaaatgaaa     6240
gcaattcaca actgaaggcg ggaacctata cgctagctaa cggttgtgtt atatctcaaa     6300
gatactcaaa aatgaaagca attcacaaca tcgggccgat ggggtacacg atggaacgag     6360
ttgtgttata tctcaaagat actcaaaaat gaaagcaatt cacaacatat tattaaccca     6420
aagggcggcc acgcgggttg tgttatatct caaagatact caaaaatgaa agcaattcac     6480
aacagattaa cgacgcgatc gctaaagctt acggttgtgt tatatctcaa agatactcaa     6540
aaatgaaagc aattcacaac aggagcgcaa acaattgcag tattaactgg gttgtgttat     6600
atctcaaaga tactcaaaaa tgaaagcaat tcacaacgaa gcccgcgaag aggatttaga     6660
tacacttgtt gtgttatatc tcaaagatac tcaaaaatga aagcaattca caacaaaacc     6720
tttatgatgg ctcaacagag ttttgttgtg ttatatctca aagatactca aaaatgaaag     6780
caattcacaa catgtcagca tcttgctcta atgcggcact tgttgtgtta tatctcaaag     6840
atactcaaaa atgaaagcaa ttcacaacga caagcggaat gatcttagta tctaaaaagt     6900
tgtgttatat ctcaaagata ctcaaaaatg aaagcaattc acaactattt agacaaaatg     6960
agggattacg cttcagttgt gttatatctc aaagatactc aaaaatgaaa gcaattcaca     7020
actcaaaaga tagtgggagg tttatttgaa acgttgtgtt atatctcaaa gatactcaaa     7080
aatgaaagca attcacaaca tctgtaatta ccaatagttt tatggatggg ttgtgttata     7140
tctcaaagat actcaaaaat gaaagcaatt cacaacagtc ttcaaacgct gatattaatt     7200
tatctagtgt tatatctcaa agatactcaa aaatgaaagc aattcataac gggcaaatct     7260
gtcatcattt cagttggact gttgtgtaat atctcaaaga tactcaaaat aaaagcaacg     7320
aaatagtgtc acatcccaaa gaatattcat aaaagatatt cctatttttg cgaatgattt     7380
actttctagt ggtgtcaaat attttgactt ttatagtttt cggagcagat aaatggtatg     7440
ccaaaaaaag caaaagaaga gtttcagaac tatttcttct gagtttgact tttttaggag     7500
gtactttggg agcattgtta gcgatgatga tttttagaca taaaacatca aaaaaatctt     7560
ttattcttaa acttcttatc gtaatttttg ttcagctaat tatatttgga ataatgaaga     7620
attctaaaat aaattttaac attttttaat accacaacaa tcggaatagg catcatattt     7680
tcttacatat ctatcataac accaaaaaat attattatgt caaagaaaat tgcaattcta     7740
gcaacaaacg gatttgagga aagtgaattg aaatctccaa aagaacattt ggaacaacag     7800
ggttggacgg ctcatattat tagtccagaa tcgggtacca taaaagcatg ggcagaaaaa     7860
gattggggaa aagaatacaa tgttgataaa acaattagtg aatcgagcgc atcagattat     7920
gatgctttg                                                             7929

<210>  17
<211>  6931
<212>  DNA
<213>  Artificial sequence

<220>
<223>  CRISPR-Cas Locus 22

<400>  17
gtataaatct tccagctcct gaatatcaaa gctttcttca attctttgtt ggagttcagg       60
tgttaaagcg ccctgttcat ctatagattt tacaatagat tcctttcttt tgacaatctc      120
ttcaaactgc ttgctgatct ttgagatctg ttcaatctga acttcatcca aattccctgt      180
tttatccttt cggtaacggg aaataaaagg aatagtgcag tcttctgcta ataattgtag      240
ggtattgttg atgctctttt cagagatatt aagctgcttc tgtataaatt ctacggtcgt      300
cattgttctg ttttcggatc gctaaaatag ggtttttaaa aagaaaaaag acgagttgcc      360
ccgccttgaa tgttttcaca acggaataat ccttattgtg aattgctttt caaaattatt      420
aatacaaata tagaagaaaa aaatttacca taactgtgga aatccgtaat tcagatattt      480
tttttatttc tatttttatg tagtatcaaa agttagaatg atgattaaaa atatacttgg      540
attagactta ggaaccaact caattggttg ggcattaata gaagttgatg aaaataatat      600
tcctatccga attgttgcaa tggggtctag aataattccc ttgtcaacaa gtgataaaga      660
ggagtttcaa agaggtttat caattacaaa gaatcaaagt agaacggtaa gtcgtaccca      720
gagaaaaggt tataatagga aacaattaaa gaaaaatgat ctaaagaaaa ttctaaataa      780
atacaatatt tttccatcag aagaattgtt aaaacttcca atgcttgatt tgtggaaatt      840
aagaagtgac tctgctaatc ccaatgaaaa tatttctgca gaacaattag gacgtattct      900
ttatatgctt aatcagaaaa gaggttataa atctgctaga agtgaggcta atgctgataa      960
aaaagataca gactatgttc aggaggtaaa aggccgttat gctcagttga aagagagaga     1020
gcagactatt gggcagtatt tttatgaagg gctttctacc gctttttcag acaaagataa     1080
tcggcagtat tttagaatca aagaagaagt ttatccaaga gaagcttacg tagaagagtt     1140
tgatactatc attaatgctc aaaaagataa gcatgatttt cttacagata aagtagttca     1200
tcaattaaga aatgaaatca tttattttca aaggaagctg aaatctcaga aaggattagt     1260
tagtatctgt gaatttgaag gttttgagaa aactgttttt gataaggaaa aaaacaaaaa     1320
taaagtggtg tttattgggc cgaaagtagc tcctaaaacg tctccattgt ttcagctttg     1380
ccggatttgg gaagtcgtca atacgattac tttaaaaata aaaaatccag aaggaagtaa     1440
atataaatgg ggtgaaaaaa ttccggattt aaaggagaaa gaaattttag cagattattt     1500
atttaaaaac gaaagtgtaa gttttagtaa acttctcgaa attttaggat taaaaaaaga     1560
aaatgtatat gtgaataagc aaatcctgaa aggtattaaa ggaaacgaaa catatgcagc     1620
tctttataat gttttaggcg ataatgaact tttgaatttt aatgtatcta tcattacttc     1680
aaatcatact gcgatattga tagataagaa aacaggcgaa attcttgaag aaagagctgg     1740
ccttgaactt gatgcatttt tggaaaaaga gccgttatat caactgtggc ataccattta     1800
ttccctgaaa gacttagatg aatgtaaaaa tgcgttaatt aaaaggtttg gtttcgaaga     1860
agacattgcc gaaaaattat cttgtatcga ttttaataaa caggctttcg gtaataaatc     1920
gaataaatcg atgagaaaaa ttcttccttt tctgatggag ggctatgatt attctcaatc     1980
ctgcagcttg gcgggctata atcattctaa ttctttaact aaagatgaaa gagaacaaca     2040
aattacttta gaccgattag aacttctttc caaaaatagt ttgagacaac ctattgttga     2100
gaaaattctg aaccagatga ttaatgtagt taatgcaatt cttgagcaat atggaaaacc     2160
atctgaaatt agagttgaac ttgcccgtca acttaaacaa agtaaggacg agcgaaatga     2220
aactgatttg caaaactcta aaaataaaaa gctcaatgag gaaattggaa aacgattagc     2280
ggaattggga ctgcctgtaa ccaagcgtta tattcaaaaa tataaattca tttttccatc     2340
acttagtaaa aacctgaaag atgctcacgt caataatcaa tgtatttatt gtggagaaac     2400
cttcaattta acagaagctt tgagtgggga tgcttatgat gttgaccata ttgtaccgaa     2460
aactttatta tttgatgact cacaaaccaa caaagttttg gttcatcgaa aatgtaactc     2520
gacaaaaact aatcaaactg cgtatgatta cattgctaca aaaggagatg aacaggttag     2580
ggtatactca gaacgggtgg atgactggtt caagagagga attatctctt acagtaaaat     2640
gcaaaggttg aaagtttcac acaaagaata tcttgaaaga aaaaaacttg gaaaagaaac     2700
agagacggat aagaagcttt gggaaaactt catcgacagg cagttgagag atactcaata     2760
tatttctcgc aaatcaaggg aaattttgca gaaagtgtgc aataatgtaa caacaacaga     2820
aggtggagtg actgcaaaac tgcgtaatgt atggggttgg gatgatgttt taatgaatct     2880
tcaactgcct aaatataaag aattagggca aactttcacc aaagaatgga caagcaaaca     2940
tggaaaaaga aaacaccaaa aagaagaaat cgaaaactgg acaaaaagag atgatcatcg     3000
ccatcacgcc attgatgctt tgataatagc ttgtacaaaa caaggcttta ttcaacgaat     3060
aaatactttg aattcgagtg agacaaaaga tttgatggta aaagaagttg agggagctaa     3120
aatagaattt aatgaaaagg ctacgctttt agaaaaatac ttaaaaactc agaaaccttt     3180
tgatacacat gaagtaatga aagaagctga taagatttta atttcattta aagcaggaaa     3240
aaaggtagca acaataacta aatttaaagc aacaggaaaa aataaagaga cgggggtaat     3300
tgttccgaga ggagctttac acgaacaatc tgtttatggt aaaataaaag taattgagaa     3360
tgataaacct ttaaaatact tgtttgaaaa ctcagataaa attgtaaatc caaaaattaa     3420
gaatcttgtt gaaacaaggc tcacagaaaa tgaaaataat tttaaaaagg ctttatcaac     3480
attaaagaaa aatccaatct ttttcaatga agaaaaaacc gagatattag aaaaagcatc     3540
ttgctacaat gatgccactg ttttgaaata taagttacaa aatataaaag caagtcaggc     3600
cgatgatatt gttgatgaaa gagtgaaatc tttagtaaaa gaaagacttg ctcaatttgg     3660
aaataaagaa aaagaagctt tcaaggatat tctttggctt aatgaagaaa aacaaattcc     3720
gattataacg gttcgtttgt ttgcccgtcc agatgcagat aatttacagg ctattaaaaa     3780
agataaatat gggaatgaga taggattcgt tgtgacggga aataatcatc atatcgcaat     3840
ttatgaagat aaagacaata agcttgttca gcatacttgt acattttggc acgcaataga     3900
aagaaaaaaa tacaatattc ctgctgttat tggaaattca tcagatattt ggaaccaatt     3960
attagacaaa gaacttccaa tatcattttt gaataaatta ccgatggata agctcaattt     4020
aaaatttagt gtgcagcaaa atgaaatgtt tattctgggg ttatcacaag acgaatttga     4080
tgagacaatt aaaaataatg ataaatcttt attgagtaaa tatttgtatt tggtttggag     4140
tattgcagaa ggtgattatt ggtttagaca ccatctggaa acaaagaaca ctgagttaaa     4200
gaaaactgat ggagcaaagg aaagtaaaag atattatcga ttaagttcaa aaggttttat     4260
tgacttaaat ccaataaaag tcagactgaa tcatttagga gaaattacca aaataggaga     4320
ataataatta tgatcacccg ctccatctac ataggcaacc ccgcttatct taaacttaaa     4380
gatgagcaaa tgtatatttt ggagccttcc acaaaagaaa tgaaaggtaa agttccggtg     4440
gaagatatgg gtttgttgat gttggatcat ttccagatta ctatatcgca tcaattgatt     4500
cagaaaatga tgggaaataa tgtggtagtg gtgagctgcg atagccacca tctgccacac     4560
ggaattatgc ttccgctgta tgggcacact gaacattctg atcggatcaa ggatcagttg     4620
gaagccagtg aaccactcaa aaagcaactt tggaaacaaa ctgttgaatg taaaattgaa     4680
aaccagaaag aagttttaaa acgcttagga aattattacg acccgatgat tgattatcag     4740
aatagcgtga aaagtggcga tattaccaat atggaaggga ttgcagcaca acattactgg     4800
aagtatctca tcagtttgga ttttttaaga cagcgttttg gagattcacc caatcagttt     4860
ttcaattttg ggtattcagt tctaagaagc attgttgcaa gagcgattgt agagaccgga     4920
ttacttcctg ttctcggaat tttccataaa aataaataca atccttattg tcttgccgat     4980
gacctgatgg aaccttatcg cccttttgtt gatttattag taatgcaatg gcttgcactt     5040
aattcagaaa ctgaagaatt aactaaagaa tttaaagctt tcattttaca gattgcaacc     5100
aaagatgtga aaatagatga taaaaccagg ccattattgg ttgcagtaaa aacaacagct     5160
acatcactgt ataaatgtta tacgggagaa aaacgtctga tctcttatcc tgatctgata     5220
tgaatgccga aaggtttaat gcataccgaa ttatgtgggt tttagtatta tatgatttac     5280
caacagaaac taaagccaat atgaaagacg ccaaccgctt tcgtaaatca ttgcttgatg     5340
atggctttac cttatttcag ttttcaatgt acgtaagaca ctgtccaagt cgtgaaaacg     5400
ctgaagttca tattaaaaga gtaaaattta tgcttcccaa agccggaaaa gtggccatta     5460
tgtgtattac ggataaacag tttggagata ttgaaatatt cttcgccaga aataaagaag     5520
aaccaccgcc aactttccaa caactcgaat tattctaatt tttaaattct aaataaataa     5580
taaatccgtt gattttcaac ggattaaatt ttgaggctgt gactaatcac gaagataata     5640
atttttgaaa gcaattcaca acactgcatg aactgcttta aaaacaccat ttgctgtgac     5700
taatcacgaa gataataatt tttgaaagca attcacaacc tgttccaagg caggaagaaa     5760
aaacggcctg ctgtgactaa tcacgaagat aataattttt gaaagcaatt cacaacagtt     5820
taataagttc tttgcagcct gttttggctg tgactaatca cgaagataat aatttttgaa     5880
agcaattcac aacccttgac ttaatgcatt gttgtaaaga cgggctgtga ctaatcacga     5940
agataataat ttttgaaagc aattcacaac taaacaacaa gagtcaaagt cttgtgtgct     6000
gctgtgacta atcacgaaga taataatttt tgaaagcaat tcacaactct tgcgcgtaaa     6060
tattgactaa tacaacagct gtgactaatc acgaagataa taatttttga aagcaattca     6120
caacaaattg aattaggttt ggatatcgga ataggctgtg actaatcacg aagataataa     6180
tttttgaaag caattcacaa ctgtagaagt tagtaaccaa caacgtagtg cgctgtgact     6240
aatcacgaag ataataattt ttgaaagcaa ttcacaacca agatgtaaat gttcaatatg     6300
ttcagaaggc tgtgactaat cacgaagata ataatttttg aaagcaattc acaacagaag     6360
caatcttatc tgtatccgaa cttttgctgt gactaatcac gaagataata atttttgaaa     6420
gcaattcaca accccgacga tgtccttttg cctggatgaa ttgctgtgac taatcacgaa     6480
gataataatt ttatgctgtc aattttaaaa atatacaata aaaaccaaaa tttttcattt     6540
cttgatgtat gttaaggtca cagaaataaa gtttctttac ttttggaatc ttaaaataca     6600
aactttttta aacaattcaa tatgaaaaaa attagcgtaa ttgcattagt aggagtagga     6660
ttgcttgtag catcatgtaa taaaggaaaa tcagcagata ctgcagctac agctcaggag     6720
cagaccgttg cagaaagcaa aggagaagta ttggcggtag atgctgcaac ttctgtagta     6780
aactggaaag catatcacaa aggaggtatg gcacctcgtt ggggaacact tagcgtaaaa     6840
tcaggagata tcagtgttga tggaggtcag gtttctgcag gaaactttgt aatcgatatg     6900
aactctatca aagtagatcc tgcttcagta a                                    6931

<210>  18
<211>  8221
<212>  DNA
<213>  Artificial sequence

<220>
<223>  CRISPR-Cas Locus 23

<400>  18
cataatggtt ttgttgcttt cgtacaaact cgaatcatgg taatcgctct aaatctctta       60
caatggattc aatctcgctt tcagtgatat tttcggagac gtaggcagaa cgtaaatagt      120
tttttaaatc ttccttaagc aacacttgtt cactaacgat tatgtccgta aaccgttggt      180
gttcctctaa tcatttggtt tatgaacatg aggttttaat gtaggatgct taggcttcgt      240
ttcggggtta actctccttc ttaaatcatc ttttccttct tctgtctttg gttttggtcc      300
tggtttaatt gcttgaattg tttccataat aaatactttt ttaaaaatta gttactaaac      360
ccatctttta gaagggcttt gagacaaata acagtattag ggttttaagt acattacgga      420
aaaccttttt acaagtaaat aattataaaa cttactttat ttactcattc taattcaagt      480
ggatctatta ataatagaag tatgctattt aattaaaaaa tagcaattac aattaggtgc      540
tattttattg cattcaattt gtgcttgcga aacatattaa ataaaatcca tagaaaaagg      600
cgagtctccc cgccttaaat gttttcacaa cggaataatc cttattgtga attgcttcaa      660
aattgtattg caataataca ataaaatatt attctataat tatggttttc cataaaactg      720
ttaattttct tttgattaaa tttaaaaatt aatttagata accagaaaat cattataaaa      780
aatagtttga aatgaaaaaa atattaggat tggacttggg gacaaatagt attggatggg      840
ctttgattga aattgataaa aataatattc ctattagcat tattgcaatg ggttctcgaa      900
taataccttt atcatctagt gataaagaag agtttcaaag aggtttgtca ataacaaaga      960
atcagagtag aacggttagc cgcactcaaa gaaaaggata tgaccggaaa caattaaaaa     1020
aaagtgatct aaagaaaatt ctaaataaat acaacatttt tccttcagaa gaattattaa     1080
aacttccaat gcttgatttg tggaaattaa ggagtgattc tgctaatcca aatgaagata     1140
tttctgccga acaactaggc cgtatattgt atatgctaaa tcagaaaaga ggctataaat     1200
ctgctagaag tgaagcgaat gctgataaaa aagataccga ttatgtacaa gctgtaaaag     1260
gacgttatgc tcatttgaag gataggactc agactattgg ccaatacttc tttgaagaat     1320
tagacaatgc aaatactaat aattcttatt ttagaataaa agaagaagtt tatcccaggg     1380
aagcttatac agaagaattt gacgccataa ttaatgctca aaaaggtaaa cacgactttc     1440
ttaccgatga agttgttcat caattaagga atgaaatcat ttattttcaa agaaaactga     1500
aatctcaaaa aggattagtg agtatttgtg aatttgaagg ttttgagaaa actattttcg     1560
ataaggaaaa agacaaaaat aaagtggtac ttgttggtcc aaaagttgct ccaaaaacct     1620
ctcctctatt tcaactttgc cgtatttggg aggttgtcaa tacaattaca ttaaaaataa     1680
aaaatccaga aggaagcaaa tacaaatggg gtgaaaaaat tccaaattta aaagagaaag     1740
aaattttagc agattatttg tttaaaaatg aaagcttaag ttttagtaag cttcttgaaa     1800
ttttagaatt aaaaaaagaa aatgtttatg tgaataagca aatccttaaa ggtcttaaag     1860
gaaacgaaac ttattctact atccatagta ttttaggaga taatgaactt ttaaattttg     1920
atgtgtctat cattacttca aatcatacat caatgttggt agacaaaaag acgggagaaa     1980
ttttagaaga aagagcgggt cttgaacttg atgcatcatt agagagagaa cccctatatc     2040
aattgtggca tacaatctat tcattgaaag atttagatga atgtaaaaat gccttaatca     2100
aaagatttgg ttttgatgat gaaattgcta aaaaattatc tcgtattgat tttaataaac     2160
aggctttcgg aaataaatcg aataaatcga tgaggaaaat tctacctttt ctgatggaag     2220
gctacgatta ttctcagtct tgcagtttgg ctggttataa tcattctaat tctttaacga     2280
aggatgaacg agaacaacta atcactttag accagttagc actccttcct aagaacagtc     2340
tcagacaacc aattgttgag aaaattctga atcagatgat taatgttgtt aacgcaattc     2400
ttgaacaata tggcaaaccc tctgaaatta gagttgaact cgcacgtgaa cttaaacaaa     2460
gtaaggacga gcgaaacgat acagatttac aaaattcaaa aaataaaaaa ctcaatgagg     2520
aaatcagaaa acgattggtt gaactgggat tacctgtaac taaacgatat attcaaaaat     2580
ataaatttat ttttccttct cttagtaaaa atctgaaaga tgctcacgtt aacaatcaat     2640
gtatttattg tggagaaaca tttaacttaa cggaagcttt gagtggtgat gcctacgatg     2700
ttgaccatat tgtgccgaaa gctctattat ttgatgattc tcagaccaat aaagttttag     2760
ttcacagaaa atgtaattca acaaaagaca aattaacagc atacgattat atttctacaa     2820
aaggaataga gcaagttaga gtatattctg aacgtgtgga tgattggttc aaaagaggta     2880
ttatttctta tagtaaaatg caaaggttga aagtttcaca cgaagaatat ctggaaagaa     2940
aaaagatagg aaaagaaaca gagactgata aaaaactttg ggaaaacttc atcgagagac     3000
aattgagaga tactcagtat atatctcgta aagcaagaga aattttacat aaattatgca     3060
acaatgtgac tacaacagaa ggcggagtta cagcaaaact tcgtaattta tggggttggg     3120
atgatgtttt aatgaatcta caaatgccta aatacaaaga attaggacaa accgtcatca     3180
aagaatgggc aagcgatcat ggaaaacgaa aacaccaaaa agaagaagtc gaaaactgga     3240
caaaaaggga tgaccaccgc catcacgcca ttgatgcttt ggtaattgct tgtacaaaac     3300
aaggttatat tcagcggata aatactttga attcaagtga taccagagat ttgatgataa     3360
aagaagtgga agaagcgaaa atagaattta atgaaaagtc aacactttta gaaaaatatt     3420
taaaaactca agagccgttt actactcaag aagtgatgaa agaggctgat aagattttaa     3480
tttcttttaa agctggcaaa aaagtagcaa caataactaa atataaagct acaggcaaaa     3540
acaaaaatac tggtgttctt gtcccaagag gagctttgca cgaacaaaac gtttatggca     3600
aaataaaagt gattgaaaag gataaatctt taaaatacct attcgaaaat tcagataaaa     3660
tagtaaactc tagtattaaa aaacttatag aagtaaggct tttggataat gaaaataatt     3720
ctaaattggc tttatcctct ttaaagaaaa acccgatttt tctaaatgaa gaaaaaaaag     3780
aagtattaga aaaagcgtct tgttatgagt atgtcactgt taaaaaatat cccttgaaca     3840
caataaaagc caaccaagct gatgatattg ttgatgaaag agtgaagttt ttagtaaaag     3900
aaagattatc tcaatttgga aataaagaaa aagaagcttt taaagatacg ctttggttta     3960
atgaagaaaa acaaattcct attattactg ttcgtttatt tgctcgtcca gatgcaaata     4020
atttgcaggc aataaaaaaa gataagaacg gtaaagaaat aggatttgta gtgacgggaa     4080
acaatcatca tattgcaatt tatgaagaca aagacaataa acttattcag cacagttgta     4140
cattttggca tgcagtagaa agaaaaaaat acaatgttcc aaccgttatt aaaaattcat     4200
ctgatgtttg gaatcaatta ttacacaaag aattaccaga atcattttta aataaattac     4260
ctgctgatta tctcaattta aaattcagta tgcaacaaaa tgaaatgttt attctgggct     4320
tatcacaaga agaatttgat caagcaatta aaaagaataa taagccctta ttgagtaaac     4380
atttgtattt agtctggagt atcacagatg gagattactt ttttagacat catttagaaa     4440
ctaaaaatac agaattgaag aaaacagacg gagcaaagga gggtaaaaga tattttcgat     4500
taagtacaaa agggcttaca gatttaaatc cgataaaagt tagattaaat catttaggag     4560
aaataactaa aataggagaa tattagttat gataaaacga acccttttct tcggtaatcc     4620
tgcttatctg agtaccaaga atgagcaaat tctaatttct tatccagaca aggaacagga     4680
gagtaaaaca gttgctattg aagatattgg agtaatcgtt ttggaaaacc aacaaattac     4740
cattactaat ggattattag aaaaattgac ccgtaataat gtagcattga ttaactgtga     4800
tcaacagcac ttgcctattg gtttattgat gcccttaagc ggacataccg aacaaacgga     4860
acgttttaaa aaccaaatca atgcatctgt cccgcttaaa aagaatttgt ggcaacaaac     4920
cattagttcc aaaatatcta accaagcagg actgctcaaa gaaaaaggaa ttccgtgccg     4980
aaaaatggaa ctatgggcaa aagaagttac ctcaggtgat gcactcaatc acgaatcgag     5040
ggcagccgta ttttattggc aaaacttgat tacagtagaa aatttcaccc gaggacaaaa     5100
aggaattcct cctaataatt tattgaatta tggctatgct attttacgag cgattacggc     5160
aagagcgatt gttagttctg gaatgttacc caccttagga attttccatc gcaacaaata     5220
caatgcttat tgtctagccg atgatattat ggaaccctat cgcccttatg tcgatttgat     5280
tgtttgccat atcatggaaa ctgaagattc ttacgacgaa ttaactatcg aaattaaaaa     5340
gcaattacta ggtattgcca ctattgatgt gtttatagat ggaaaaaata gcccgttaat     5400
ggtagccatg agccgcacaa ccaattcgct acacgaatgt tttgaaggaa cagctaggaa     5460
aattttatac cctttgtatg tatgatgaac attacagccg tttaaaccaa tatagaagtt     5520
tgtggatatt agtatttttt gatctgccca ccgaaacacg caaggagcgt aaaattgcta     5580
gtggatttcg caagaaatta ttagacgatg gtttttctat gtttcaattt tcgatctata     5640
tgcgtttttg tgccagtaga gaaaatgccg aagtacatag caaaagaatt aaaaatagtt     5700
taccggagca cggcaaaatt ggcgtgatgc aaatcaccga caaacaattt ggcatgatgg     5760
agctttttta tggtaaaaaa ccagtagaac cagaaaaacc ctctcaacaa ttggaattgt     5820
tttaattttg ctagaataaa aaaatcgatt agaacactat cgttctacct cttacccctt     5880
attctttttc catttctaca actacttata actgccaaca tatcaaccga ttaaatcgag     5940
gtatgttggg aatcataagt aaaaatacaa ttttgaaagc aattcacaac aaacaagaag     6000
gaattaacac agctatcgaa gttgggaatc ataagtaaaa atacaatttt gaaagcaatt     6060
cacaaccaag tacccatttt cgcgtagcaa gagccgttgg gaatcataag taaaaataca     6120
attttgaaag caattcacaa cgtgcaatga aaaagggtga tgttcaggac tgttgggaat     6180
cataagtaaa aatacaattt tgaaagcaat tcacaactgg aatggaccaa ggattcaacg     6240
atcctacgtt gggaatcata agtaaaaata caattttgaa agcaattcac aacaggtgta     6300
gggttaactc cgacaggttt taggttggga atcataagta aaaatacaat tttgaaagca     6360
attcacaact acaaacaaat gattcaagtg aaaattttag ttgggaatca taagtaaaaa     6420
tacaattttg aaagcaattc acaacattct ttaaatactt tcttaatatc tcttagttgg     6480
gaatcataag taaaaataca attttgaaag caattcacaa cgtgcaatga aaaagggtga     6540
tgttcaggac tgttgggaat cataagtaaa aatacaattt tgaaagcaat tcacaacaaa     6600
gctactatac ttcacttttt tataatgttg ggaatcataa gtaaaaatac aattttgaaa     6660
gcaattcaca acagatgaaa gttctatttt gaaaaattat agttgggaat cataagtaaa     6720
aatacaattt tgaaagcaat tcacaactgt ctgagaattt aatcatttct tttcgaagtt     6780
gggaatcata agtaaaaata caattttgaa agcaattcac aactaaattt gaagcgttta     6840
aaaatacccc accgttggga atcataagta aaaatacaat tttgaaagca attcacaaca     6900
gaaactaagt gttttacttt tccgtcgagt tgggaatcat aagtaaaaat acaattttga     6960
aagcaattca caacgaaagc tcgtaatgtc gaaacagctg ttttgttggg aatcataagt     7020
aaaaatacaa ttttgaaagc aattcacaac ataagtttgt tgaacaatac caacgagaat     7080
gttgggaatc ataagtaaaa atacaatttt gaaagcaatt cacaactggg tatccatgaa     7140
agaaatgaat taatagttgg gaatcataag taaaaataca attttgaaag caattcacaa     7200
ctcatcagcg ggtctttctc ctgctgatag ggttgggaat cataagtaaa aatacaattt     7260
tgaaagcaat tcacaacatt ttagatattg ctaaaaaaaa tcctaaggtt gggaatcata     7320
agtaaaaata caattttgaa agcaattcac aactcttcgg gtgttggtct gtaaatttta     7380
agagttggga atcataagta aaaatacaat tttgaaagca attcacaaca caatcaaaac     7440
aaatcaatct ggcaacacag ttgggaatca taagtaaaaa tacaattttg aaagcaattc     7500
acaacagaaa ccgttaacgg tggaacaagt caaacgttgg gaatcataag taaaaataca     7560
attttgaaag caattcacaa caattttgtg aacatggttt attttatgca agttgggaat     7620
cataagtaaa aatacaattt tgaaagcaat tcacaaccat ccaaactgcg tttagccact     7680
tcggtatgtt gggaatcata agtaaaaata caattttgaa agcaattcac aactagttgt     7740
agatgtttta tcagcatcta catgttggga atcataagta aaaatacaat tttgaaagca     7800
attcacaaca cagcggcgtc gatgttgttg tttagttcag ttgggaatca taagtaaaaa     7860
tacaattttg aaagcaattc acaacataat atgataaaat atatcaaaaa gtgagttggg     7920
aatcataagt aaaaatacaa ttttgaaagc aattcacaac gaatggggtg taaatgattt     7980
ttttgcattg ttgggaatca taagtaaaaa tacaattttg aaagcaattc acaacgcaaa     8040
aagctgtgtg ttgttgatga agaaagttgg gaatcataag taaaaataca attttgaaag     8100
caattcacaa caaaatagct attgaaaaag cacgtgattc gttgggaatc ataagtaaaa     8160
atacaatttt gaaagcaatt cacaactaat tttaggatca tcttctaaag tgaattgttg     8220
g                                                                     8221

<210>  19
<211>  8221
<212>  DNA
<213>  Artificial sequence

<220>
<223>  CRISPR-Cas Locus 24

<400>  19
ataaatacct gtcttctgat aaaatggagg gacgttttcc tggtacaaaa ggcaataatg       60
aagcggcatc ttacattaaa agatatttca aaaaatatgg tcttaaggaa ttcaacagaa      120
attactatca aacttttaaa ctatttgtaa aagaaggaat caataaagtg aaatcggata      180
gtgtcaatac tcaaaatgtt gtagggtatc tcgaaggttc tgatgaaaag ctaaaaaatg      240
aatatatagt aataggggct cattatgatc actggggctg gggaggacaa aattcgggaa      300
gtaaaaagaa agaagctttc gccattcata acggagcaga tgacaatgca tccggggttt      360
cggctttgtt gtgtatactt caggaattat caaatgctaa agtcaaacct aaaaggagta      420
ttatttttat atcttttagt ggggaagaag aaggcttatt gggttctaaa tattttgtgt      480
ctcatttgcc ggtagaaaaa aatgccgtga aagtaatgct gaatatggat atggttggaa      540
ggcttaatga ggagaagcaa atttacatgg gcggtgcagg aacatttccg aatggagtag      600
aattgatgaa gaaattgggt gaaaacagta ccctgaatcc ggtcatacat gctggtgaag      660
ttggaggctc agatcatgta tcattttata aagctgctat ttctgctata ggatttcata      720
caggaggcca cccgcaatat catacacccg aagacgatat agatttaata aatattcagg      780
gcggtgcttt ggtatctcaa tatatttaca atgctttagt agcaattgca aatgactcgc      840
aacaactgta ttttattaat caggattagt aattctcggg ttagatccta ctatacaaac      900
aatctattta cggtagatat tctactgatt tgtataaatg aaaagtccca ccgaagcagg      960
actaaagatt ttcatctacg gcatatagcc ttattgtgat aagattaaag attagaaatt     1020
ttaatcagtt acaaatatat ataaaaagga gattaagtgg aatatggtaa tccgtaattg     1080
tgttaatttt ttttatatta tatttcgttc atattaaatt ttaaaagata tggcgaaaat     1140
tttaggattg gatttaggga caaactcgat tgggtgggcg attgttgata aagatggaaa     1200
tgatttttcc cttgtagata agggagtgag aatattttcc gagggagtaa aatctgaaaa     1260
aggaattgaa agttctcgtg ctgcggaacg aactggttat agaagcgcaa gaaaaattaa     1320
ataccgcaga aaattaagaa agtacgaaac cttaaaagtt ctttcctcaa atggaatgtg     1380
tcctttgtcg gttgaagaag ttgaagactg gaaaaaatcc gggtttaaaa aatatcctct     1440
taatcctgaa tttttgaaat ggttacgaac ggatgaatac caacatataa acccatacta     1500
ttttagagat agagcaagca agcaaaaagt tgccttattt gaattgggac gtgctttata     1560
tcatattgct caaagaagag gttttttgag taatcgtcta gatcagtcag ctgaaggagt     1620
ttttgaagaa cataatcctc aaatccaaag tttgattgaa gatttggatg attcgaaatt     1680
aattcttgat gaattgaaaa attattatgt tgataaagga ataattgaag aagctgaaaa     1740
aggagttttt aaaaaagatt tagatgaagg tgagaaaaaa ctaaaatcac tttataattc     1800
gttagtagga ataattaaga agaatgaaaa caacgttgaa aaatgcaaag aggaatttat     1860
tgcaaggctt aataaaaaag aagatttagg aaaagtaaaa ggaaaaatca aagatatttc     1920
gcaagcaatg cttgatggta attttaaaac tttaggacaa tattttttca gtctttacaa     1980
taaaggaaaa ataagaaatc aatatacttc gagagaagaa cattatttgg aagagtttat     2040
tactatttgt aaaattcagg gaatcgaagg aattgatgat aaagaaaaat tacctgaaaa     2100
gaagtttaca ggcttagcca aagatttgta caaagccatt ttctttcagc gtcccttaaa     2160
atctcaaaaa ggactgattg gaaagtgttc ctttgagaaa agcaaatcac gttgtgccgt     2220
ttcgcatccc gattttgagg agtacagaat gtggacttac ttaaacacta tcaaaattgg     2280
aacacaaagc gaaaaaacat tacgtttttt aacgcaagat gaaaaattaa aattagttcc     2340
aaaattctac agaaaaaatg attttaattt tgaagtttta gccaaagaac ttgttgaaaa     2400
aggagcaagt ttcgggtttt ataaatcttc caaaaagaac gatttttttt attggtttaa     2460
ttacaaacca actgattcgg ttgcagcttg tcaagtttca gcatctttaa aaaatgtgat     2520
tggtgaagac tggaaaacaa aaatatttac ttataaaact ttaaatgcaa aagaagaaga     2580
agtaacaaaa tctgttgatt ataaagactt atggcactta ctttccgtag caacatcgga     2640
tatttatttg gaggaatatg ctaaagataa attagggttt gacgacaaaa atgccaaagc     2700
tttcagtaaa ataaaactca aaaaagattt cgctagtttg agttcatcag cgatcacgaa     2760
aattttgcct tatgtaaaag aaggactttt gtattctcac gctgttttta tggcaaatat     2820
tgaaaatatt gttgatgaaa atatttggaa taatcttgac caaagaaatt atattcagtc     2880
taaaatagcc gaaattattg agggctatac ttttgaaaaa acaggtttgg aagtagtcaa     2940
cagccttatt aaagaatata aaacagaaaa tgattacagc aaaaaagtat attattcaaa     3000
agaagctgaa ccagaatttg aaaaagattt aaagcaaaaa ttagtagttt tttataaatc     3060
aaatgacatt gaagatgaaa atataaaaca agctattttt aatgatttat attcagtttt     3120
aattgaccaa cttaaaaaat atgagtatat caaaatacaa cgattggatg agaaagtttt     3180
agagttttta aaaggtgaaa atgaagacgg agaagttttt tgcaataatc caaagcaatt     3240
aaaaaagctg tatcatccat cagatattga aatttttaaa aagcaaaagg tcaaagataa     3300
agatggtaaa gaaacgggac agcttatttt aggtagccct ttaacttctt caatcaaaaa     3360
tccgatggca atgcgtgctt tgcatcaatt gcgtaaagtt ttaaatactt tgattttgga     3420
aggtcaggta gatgaaagta caaggattca tattgaaatg gctcgtgagt taaacgatgc     3480
caaccgaaga aaaggaattc aggattatca aaaagagaat aaagatttca gagacaatgc     3540
tattaaagaa atcaaaaaac tgtatttgga cgaatgtggt aaagaagtag aaccaacgga     3600
agatgatatt ttaagatatc agctttggat tgaacaggac aaatgtgaga tttacgaaca     3660
aggcaagaat attagtattt gtgatataat aggaagtaat ccagcttatg atatagaaca     3720
tacaattcca agaagtattt cgcaagataa ttctcaaatg aataaaacgc tatgcagtca     3780
gcgatttaac agggatgtca aaaagcaaaa aatgccaatt gaattgagca atcatttgga     3840
aattttgcca agaattgcgc attggaaaga agaagccgac aacttatcaa gggaaattga     3900
gataattagc cgttccataa aagccgcatc gaccaaagaa attaaagata aaaaaatacg     3960
aagaagacat tatctgactt taaaacgtga ttatcttcaa gggaaatacg atcgatttat     4020
ttggaaagag ccaaaggttg ggttcaaaaa cagtcaaatt ccggatacag gaattatcac     4080
caaatatgcg caagcttatt taaaatcgta ttttaaaaga gtagaaagtg taaaaggcgg     4140
aatggttgcc gagttcagaa aacaatgggg aattcaggag agttttattg acgaaaacgg     4200
atttaaacaa tacaaagaaa aagatagaag taaacacacc catcatacca ttgatgccat     4260
tactattgct tgtatgacca aagacaaata tgatgttttg gctaaagcct ggacttctga     4320
agatgaacaa gataaactaa aggcaaaagc tctaatggca gatgccaagc cgtggaaaac     4380
ctttaaagaa gatttactca aaatagaaga tgaaatttta gtttcacatt acacgcccga     4440
taatgtaaaa aaacaatcta aaaagattat tagggttcgt ggcaaaaaac aatttattgc     4500
agaaattgag agagatgtca aaggtaaagc aatacaaaaa aaagatgcta atggaaaagt     4560
agtttacaag ttaaatgata aaggagaaaa gatcccaaga ttgcagcaag gtgatactat     4620
tcgaggctcg ttacaccaag atagtattta tggagcaatt aaaaatccat taaatactga     4680
tgaaatacgt tatgtgattc gtaaagattt agaaagtctg aaagcaagtg atatcgaaaa     4740
cattgtggat gaaactgtaa aagagaaagt aaaacaagcc gttacaaata aagttttgtt     4800
gctttcttcc aatgcccaac aaaaaaataa aattgccgag aatgaaaagg tttggatgaa     4860
taaagaaaaa caaatttcca ttaacaaagt tagaatttat gccaattcag ttaaaaaccc     4920
actggaaata aaagagcata gtttattgtc aaaatctcgt cacgaacaca agcaaagagt     4980
atatggtcag aatgatgaga attatgcaat ggcactttat gagttagatg ggaaaagaga     5040
atttgaattg attaataatt ttaatttggc taaactcata aagaatggac aaggatttta     5100
tcctttaaat aaagaaaaag aattaaaagg taaaaaagtt ttatatccga ttgcaaaaag     5160
taacagcaga gatgttgttt tgaaacgagg acaacaagtt gttttttttg ataaagaagt     5220
tgaaaagcca aaggatattt ctgaaatctt ggattttaaa agaagggttt atataattga     5280
aggtttgtcc attcaaagaa taaaatcggg gaataatgaa tttgaatatg gtgtaattat     5340
gttaagatat ttcaaagaag caaggaaatc agatgaaatc aaaaaagata attttaaacc     5400
agatggtgtt tttaaattag gagaaaataa accaacaaga aaaatgaatc acagccaatt     5460
taccgctttt gttgaaggta ttgattttaa agttttacca tcaggaaagt ttgtcaaaat     5520
ttgaaaaaaa atattatgga tggatcaaaa ttaacaaaag aacaaatcgc aaaaattcaa     5580
gcaaaaattg ataaagcgga aaaaagcggt tttagtacca aaacaaaaga agagttatta     5640
gctgacatca agaaaaaata taatgtttag tttgtacttc cttcgtcgga tgacaaacaa     5700
atgcaaaatg ttctttgata taaagttttt caaactgtta aacatctcaa accacaactg     5760
aaagttcacg tccctgccgg gcggatgtca gaactttcag ttgtggtttg attaaagatt     5820
agaaaacacg atattgcagt attatacgtt aataggaacc gaaggttgtg gtttgattaa     5880
agattagaaa acacgatatt tagcaatgta taattaagta agtcagagtg gttgtggttt     5940
gattaaagat tagaaaacac gatattttta tatgcttcta tttccaaact caatacgttg     6000
tggtttgatt aaagattaga aaacacgata tttaaatgaa aaacacgaca aactacaact     6060
cagttgtggt ttgattaaag attagaaaac acgatattag atataatgtt ttgcttattg     6120
tctttcaagt tgtggtttga ttaaagatta gaaaacacga tatttttaat ctatttctat     6180
tttcttcaat atgagttgtg gtttgattaa agattagaaa acacgatatt aatgtggatt     6240
ttgaggaatt tgtctcttta gttgtggttt gattaaagat tagaaaacac gatattacaa     6300
atcagaagca ttaaacgcag aaacagttgt ggtttgatta aagattagaa aacacgatat     6360
ttcaatttga aaatgtgggt acgtttattg tgttgtggtt tgattaaaga ttagaaaaca     6420
cgatattagt aactgaaaaa ttgaataaag aaaatatgtt gtggtttgat taaagattag     6480
aaaacacgat atttcatttc acgcacgtat aaaggcgcac ttagttgtgg tttgattaaa     6540
gattagaaaa cacgatatta acaaacagga agcactaaat gcagaaacag ttgtggtttg     6600
attaaagatt agaaaacacg atattttaaa caaaaacaaa taactatgaa gtatgttgtg     6660
gtttgattaa agattagaaa acacgatatt tctattactc ctgcagctaa accacataag     6720
ttgtggtttg attaaagatt agaaaacacg atatttacaa atacgcacat cgagaggtgg     6780
cataagttgt ggtttgatta aagattagaa aacacgatat tatcttatag gtgaaagatt     6840
cgattcaaca ggttgtggtt tgattaaaga ttagaaaaca cgatatttct ttgtatccaa     6900
cgttaggggc gacattagtt gtggtttgat taaagattag aaaacacgat atttttattc     6960
gttacattaa catatgaaac taagttgtgg tttgattaaa gattagaaaa cacgatattt     7020
ttaaagtttt aacgtcgtca gtggtagatg ttgtggtttg attaaagatt agaaaacacg     7080
atattatttt ccccgttgtt actcttgttt ccatagttgt ggtttgatta aagattagaa     7140
aacacgatat tagactatgc aaccgtaaca gccaatttta ggttgtggtt tgattaaaga     7200
ttagaaaaca cgatattaca aagaaatgaa atcagaatgg gaactagttg tggtttgatt     7260
aaagattaga aaacacgata ttaacacaaa cgggatagga ttaaaaatgg agttgtggtt     7320
tgattaaaga ttagaaaaca cgatattttc tactactaac ataagccaat tccaatcgtt     7380
gtggtttgat taaagattag aaaacacgat attattgttt atacgttcaa cttctgattt     7440
gttgttgtgg tttgattaaa gattagaaaa cacgatatta acattaactt ccactaatac     7500
aggtacaggg ttgtggtttg attaaagatt agaaaacacg atattgttaa ttttattagc     7560
aaagaatgtt ttatagttgt ggtttgatta aagattagaa aacacgatat tcatgtacaa     7620
caaaaaagaa agcagctaat ggttgtggtt tgattaaaga ttagaaaaca cgatattcta     7680
cgaacttttt actcatagca agttctgttg tggtttgatt aaagattaga aaacacgata     7740
ttagtttcct cctgggttta taggaggaaa agttgtggtt tgattaaaga ttagaaaaca     7800
cgatattgaa ctttataaaa cagttcagta ccaagctgtt gtggtttgat taaagattag     7860
aaaacacgat atttttttca catttttaaa cagtgtttaa atggttgtgg tttgattaaa     7920
gattagaaaa cacgatatta tttataaacg aaacccctaa ctcaataggg ttgtggtttg     7980
attaaagatt agaaaacacg atattaaaac tgagtaactc caccgctttc acttgttgtg     8040
gtttgattaa agattagaaa acacgatatt cttaatgcag agcttacaac ttcgtttaaa     8100
gttgtggttt gattaaagat tagaaaacac gatattttta tagttcaatg tttcgccacc     8160
attaacgttg tggtttgatt aaagattaga aaacacgata ttaatgtctg aaatattagc     8220
t                                                                     8221

<210>  20
<211>  8221
<212>  DNA
<213>  Artificial sequence

<220>
<223>  CRISPR-Cas Locus 25

<400>  20
agtgtaccga atacttgata gtgatggaaa acccatcggg gttcctatta aagccagtga       60
cttttataat aaaccgactc ttaaattttt agagcaaaaa tttctatccg ccggtagtgg      120
aagagtatcg atgaaaaaca ggataaagaa tgccgtggac ctggcgcttc ttaataaaag      180
catttcattt tccgacctgg gaaaactgct cgaaaaagaa gggattaata ttatttcaag      240
aaaaagtgct gccgggatga tttatggcat cacctatgtg gatcatacta caaaatgcgt      300
atttaatgga agcgttttgg gcaggcagta cagcgcaaaa gcagtacagg aacgctgtaa      360
tttaatgggt aaaactctgc ggggttccga taacgacata aacataaaat ccaaagctga      420
attaatggga agtatatcga ataaagattt atttgaaagt agtaaaactg atggctttga      480
tactgctctg gctaaagttt tggatgtatt gacccggatg gaatccgcgc aggcttacct      540
gcccaatcag cttaaagcaa aacgcaggaa gaaaaaaagg aaagggcagt cagataatca      600
ataaaaaatt aatatcatgg gaatgcagac aggagaaaat gaacaggcat tgagaaagat      660
attggatatg acaaggctca tagggattat tattctggta attcactttt actattattg      720
ttattcagcc ttcaagcagt ggcagctggt aagtgagttt accgataaaa ttttaggcgg      780
tatttatact tgtaattcag tccgatcagc tttcttacta gttctttttc cgtatagata      840
tcccgtgtag tttaatatat ttgactaatt ttattcaaaa atctaaataa ggtcctctgc      900
aaaacaatca gataccatac aactattcaa atctgtcttt agaggtcgta atgatgtatt      960
tgccgttcgt tgggaaaaag ctggaaagtc tgggtatatg ccagcatatc aatatgacct     1020
gtataattat cgacaacata caatgaatgg agttatggga tttttttggc gaaccgcctt     1080
tccttcccga actttgtttc agaattaagc cttatagatt ttgcaaatct caaggttata     1140
caaaacagtt atttcagtat aaaaaaagtc ccaccgaagc aggactaaag attttcatct     1200
acggcatgta gccttattgt gataagatta aagattagaa attttaatca gtcacaaata     1260
tagagaaaaa atattatggt agaaaaagga aaaccgtaat tgtcttaatt ttttttatag     1320
taaattccgt gcagattaaa tttaagaaat atggcaaaga ttttaggatt agatttaggg     1380
acgaactcga ttggttgggc gattgtagat aaagacgaaa ataatttttc attagtagat     1440
aaaggagtca gaatattttc tgaaggagtt aaatctgaaa aaggaattga aagttctcgt     1500
gctgctgaac gaacaggatt tagaagtgca aggaaaatta aatatcgaag aaagctaagg     1560
aaatacgaaa ctttaaaagt tctgtcatca aatggaatgt gtccactttc aattgaagaa     1620
gtggaagact ggaaaaaatc aggttttaaa caatatccac ttaatcccga attcctgaaa     1680
tggttaagaa ctgatgaggc tgaaaacatc aatccttatt tttttagaga taaagccagc     1740
aaacaaaaag ttcctttgtt tgaattagga cgagcattct atcatattgc tcagagaaga     1800
ggttttttga gtaatcgttt agatcaatct gcagaaggaa ttttagagga acattgccct     1860
aaaattgaaa caattgtaga agatttgaat tcttatgaag aagttttaga aaatttaaaa     1920
gattactttt tttttgaaac tggaattctt gatgctaatg aaaaaagtgg ttatgcaaaa     1980
gatttagatg aaggtgataa aaaattggtt tctttataca aatcacttca taccattgta     2040
aaaaagaatg atactaattt tgaaaaaggt aaagcagaaa ttattgaacg actcaacaaa     2100
aaagatgttt taggaaaagt aaaaggaaaa attaaagata tttctcaagc tatggtcgac     2160
ggaagtttta agactttagg gcaatacttt ttcagtttat atagcaaaga aaaaattaga     2220
aatcaatata cttcaagaga agaacattat ctcgaagaat tcataactat ttgtaaagtc     2280
caaggaatcg attccattaa cgagaaagaa caattgccag agaagaaatc cgatggttta     2340
gccaaagatt tatacaaagc catattcttt caaagaccat taaaatctca aaaaggattg     2400
attggtaaat gttcttttga aaagagtaaa tcccgctgtt ccgtttcgca tcctgatttt     2460
gaagaataca gaatgtggaa ttacattaat acaattaaaa ttggaacaca aagcgaaaaa     2520
acattgcgat ttcttacgca agaagaaaag ttaaaattag ttccaaaatt ctacagaaaa     2580
aacgatttta attttgaagt tttagccaaa gaattaattg aaaaagggac gagctttgga     2640
ttttataaat cttctaaaaa gaacgattat ttttattggt tcaattttaa accaaccgat     2700
tcggtttctg cttgtcaggt ttctgcatca ttaaaaaata ttattggaga agattggaaa     2760
acaaaaacat tcacttacca aactttaaat gttaaaaaag aagaagttac aaaaacagtt     2820
gattataaag atttatggca cttactttca gtagcgactt ctgatattta tttgaataaa     2880
tatgcaaaag ataaattagg ttttgaggat aaaaacgcaa aagcattcag taaaatcaag     2940
ttaaaaaaag attttggaaa tttaagtttg tcggcaatta ctaaaattct gccttacata     3000
aaagaaggat tgctctattc tcacgctgtt tttatggcaa atatagaaaa cattgttgat     3060
gaggaaattt ggaaagatga acatcaaaga aaatatattc aaacccaaat agcagaaatt     3120
gttgaaaatt atacttttga gaaaagtcaa ttagaggtaa ttaatggact tataaaagat     3180
agtaaactaa aagaagaata ttattctaaa gaagcagaat caatttataa aaaagattta     3240
gctactaaat tagttttgtt ttttaaatac aatgttattg aaaatgaatc agaccaaaaa     3300
atcatttttg aaaacttatt tccaattttt attgagcaat taaaaaaata tgagttcatc     3360
aaaatccaga gattagatga aaaagtttta gaatttctta aaggagaaaa tcaagatggt     3420
gaaatatttt gcagcaatcc aaaacaatta aaaaaactct atcatccatc ggatattgaa     3480
gtttttaaaa agaaaatcat taaagacgaa tttgggaatg aaaaagtagt tttaggtact     3540
cctttaacat ctgctattaa aaacccaatg gcaatgaggg ctttgcatca attacgtaaa     3600
gttttaaata ctttgatttt agaaggtcta gtagatgaaa atacactaat tcatattgaa     3660
atggctcgcg aattaaacga tgctaacaaa cgaaaaggaa ttcaggatta tcaaaacgaa     3720
aacaaaaagt tcagagaaga tgcaataaaa gaaatcaaaa aactttattt ggatgaatgc     3780
aaaaaagaag tagaacccac agaagatgat attttaagat accaattgtg gattgaacaa     3840
aacagacaag agatttacga acaaggaaaa aatattagta tttgtgatat aattggaagt     3900
aaccctgctt atgatattga acatacaatt ccaagaagcc gctctcaaga caattctcag     3960
atgaataaaa ccttgtgtag tcaacgattt aatagagaaa ttaaaggaaa taaaatgcca     4020
attgaattga ataatcattt ggaaatcttg ccaagaattg cgcattggaa agaagaagcc     4080
agtaatttat caagagaaat tgaaattata agtcgttcca taaaagccgc tgcaaccaaa     4140
gaagtaaaag ataaaaaaat aagaaggaga cattatctaa cattaaagcg agattatctt     4200
caaggaaaat atgaccgatt tattttggaa gaaccaagag ttggatttaa aaacagtcaa     4260
attcctgata cgggaattat tactaaatat tctcaggctt acttaaaatc gtattttaaa     4320
agagtcgaaa gcgtaaaagg cggcatggtt gccgaattta gaaagcagtg gggaattcaa     4380
gaaagtttta ttgacgaaaa tggatttaag cattataaaa taaaagacag aagcaagcat     4440
acacatcaca caattgatgc cataacaatt gcttgtatga ccaaagataa atatgacgtt     4500
ttggctcacg cttgggcatt agaagatgaa caaaataaaa aagaagccaa agctattata     4560
gaaaaagcta aaccttggaa aacctttaaa gaagatttgt taaaaatcga agaagaaatt     4620
ttagtctcac attatacacc cgacaatgta aaaaaacaat ctaagaaagt tattagaatt     4680
cggggtaaaa aacaacacgt tgccgaaatt gaaagagatg aaaaaggaaa ggcaattcct     4740
aaaaaagatg ctaacggtaa aattctttac aagttagata aagaaggaaa aaaacttcca     4800
agatatcaac aaggcgatgc cattagaggt tctttgcatc aggatagtat ttatggagca     4860
attaaaaacc ctttaaatac ggaagaaatt cgttatgtta ttcgtaaaga tttagaaagt     4920
ttaaaagcat ctgatattga aaatattgtt gatgaaactg taaaagaaaa aattaaagaa     4980
gcagttgcaa ataaagtctt gttattttct tcaaatgccc aacaaaagaa taaaattaga     5040
gagaatgaaa aggtttggat gaacgaagaa aagcaagttc caataaacaa agttagaatt     5100
tatgctaatt ctgtaaaaaa tcctttggag gtaaaagaac atagtttatt gtcgaaatca     5160
cgtcatgagc ataaacaaaa ggtatatggg caaaatgatg agaattattg tatggcaatt     5220
tatgaattag aaggcaaaag ggaatttgaa ttaattaata attttaattt agcaaagttg     5280
attaagggag gacaaggatt ttatcctttt tataaagaaa aggaggtaaa aggaaaagta     5340
gttcaagttc ctattgctaa aaggaatggt agagatttaa ttttaaaaag agggcaacaa     5400
gtaatttttt atgataaaga tgttgaaaat cccgatgatg tttttgattt agtggattta     5460
aaaggaagaa tttatattat tgaaggattg tcgattcaac gccaagttgt ttctggaaag     5520
ctttatgagt ttggtagtat tatgtttcgt tattttaagg aagccagaaa agcagatgag     5580
attaaaaaag atagttttaa acccgatggt acttttaaat caggagaaat aaaaccgact     5640
cgtaaaatga atcataatca atttaccgct tttgtagaag gaattgattt taaagttttg     5700
ccatcaggta agtttattaa aatttaaaaa tttattatgg atgattcaaa attaacaaaa     5760
gagcaaattc aatctatcca agcaaaaatg gatagagatg aaaaaagtaa acccgtaaag     5820
aaatgctaat cgaattttaa aagagataag ggttggttta aaaatttaaa aagttctttg     5880
atataaagtt tttcaatctc ttaaacatcc aaaccacaac agaaaattat ggcgtccgac     5940
catcagggac gcaagcgggc aagttgtggt ttgattaaag attagaaaac acgatatcct     6000
acgccaaaat acggttcaac agcttcgggt tgtggtttga ttaaagatta gaaaacacga     6060
tatcagtagt caggaaacgc cttaatttcg atacgttgtg gtttgattaa agattagaaa     6120
acacgatatc ttaaaaatca tacttccaga gcctacagta gttgtggttt gattaaagat     6180
tagaaaacac gatatcgatt ttgcaaaagc ataaactcct cctacagttg tggtttgatt     6240
aaagattaga aaacacgata tcaatggaga gcctggaacc ttaactcctg aagttgtggt     6300
ttgattaaag attagaaaac acgatatccg ctatatttat tttagaaact gaagcaaggt     6360
tgtggtttga ttaaagatta gaaaacacga tatcccttct ccggtgaacg ccagagctgc     6420
ggcagttgtg gtttgattaa agattagaaa acacgatatc atgtatgtat atgtatcacc     6480
tatcacctat gttgtggttt gattaaagat tagaaaacac gatatccaaa tcaaaggata     6540
tttattacct gatatcgttg tggtttgatt aaagattaga aaacacgata tctttttcat     6600
tattactgag cttaaaacat gggttgtggt ttgattaaag attagaaaac acgatatccg     6660
atgcagatat aaccagccaa caaagctggt tgtggtttga ttaaagatta gaaaacacga     6720
tatccacttg ttacaatatg cgaatgaggc gttagttgtg gtttgattaa agattagaaa     6780
acacgatatc aaaattcgtt ttcattccgc ttttagccgt gttgtggttt gattaaagat     6840
tagaaaacac gatatcccaa cggtaaatta atacgtaaaa catcatgttg tggtttgatt     6900
aaagattaga aaacacgata tcggagcata acgttaatat tgtaacgtat aagttgtggt     6960
ttgattaaag attagaaaac acgatatctt atggatatcg caatcgagga gactattggt     7020
tgtggtttga ttaaagatta gaaaacacga tatctttatg ccgtttcgtt ctgccatttc     7080
ccacgttgtg gtttgattaa agattagaaa acacgatatc tacaaataag ttttaaacgt     7140
gcaactttta gttgtggttt gattaaagat tagaaaacac gatatcttta ccatagtggg     7200
agccgggttt cgatacgttg tggtttgatt aaagattaga aaacacgata tctaagtctg     7260
agacgttaac aaccctgtag agttgtggtt tgattaaaga ttagaaaaca cgatatcatt     7320
taatatggat gaaatggtta ctgttaggtt gtggtttgat taaagattag aaaacacgat     7380
atccgttatt ttatttaata ataaacaaat atagttgtgg tttgattaaa gattagaaaa     7440
cacgatatca caaattgcct aaatataagc ctccagcggt tgtggtttga ttaaagatta     7500
gaaaacacga tatccaaaac tataataaac cacctgagtg taaagttgtg gtttgattaa     7560
agattagaaa acacgatatc aattgttgtc caaattgagc cgcttgtgtt gttgtggttt     7620
gattaaagat tagaaaacac gatatcggtc aactatttct gaacggatgt gttgatgttg     7680
tggtttgatt aaagattaga aaacacgata tccaaattac gttaaggagt ataaagacct     7740
tgttgtggtt tgattaaaga ttagaaaaca cgatatcatt gagcagtaaa cacaaaggag     7800
gaaatatgtt gtggtttgat taaagattag aaaacacgat atcaaacgga gaacaagtaa     7860
tcacaaaaag tgcgttgtgg tttgattaaa gattagaaaa cacgatatca aattataatt     7920
aaacggtaga gtacaaatgt tgtggtttga ttaaagatta gaaaacacga tatccagtca     7980
agttctttgc tagatagtgt aatagttgtg gtttgattaa agattagaaa acacgatatc     8040
ctatttagac ggtaaattcg gcacagtagt gttgtggttt gattaaagat tagaaaacac     8100
gatatcattt gctgtatcgt agcaaatgcc ttgcgggttg tggtttgatt aaagattaga     8160
aaacacgata tcaaaataaa taccatgaaa ccgctttatc tagttgtggt ttgattaaag     8220
a                                                                     8221

<210>  21
<211>  8221
<212>  DNA
<213>  Artificial sequence

<220>
<223>  CRISPR-Cas Locus 26

<400>  21
aaaatagtca tctaatttta tgaatgggga gacaattaaa aggttttgtt ctgcttccca       60
aattatttca taaactgcat tttcaagatt ttttcctgta ataaatttcc ccatttaatt      120
aaattgtttt ttgcaggttg atattgaaat tatcctttat tggcataagc tttttactga      180
tttcaaaaat aggattttta tttcaaaaat agttagagat atttttagtt gaatgatact      240
ttttgtgtag gcaatgttac agatttggaa ggtcatgttt gtgttattag ccttctctct      300
gcggttgttt tgtttggtat tttaaggcag taatttcgat gatggaaggg ctgctagttt      360
gttttaatga ataaactatt aaatagttag ttagttagtt agttagttag ttagttagtt      420
agttagttag ttagttagtt cttgtgtttt ttcttcattt caatcagatt tcttttattg      480
gagatagatt tttttatttt gtttttgttt ttgttttggc cggcgaatgg ttggttggcc      540
ggcgaatggt tggttggttg gttggttgga aaaagagctt atttgaatgg aaagatgatt      600
tagcgttctt aaactatggt acagcagata atttgcctag gttatgacta atttaaattt      660
attgtatttc tgccaccagg gtaatttgtg catcctaaaa aattgtcata tgttcctgct      720
cacttaacca taaagctgct ttcgcagctg tagcatatga attgatcatc taaaatttcc      780
aggttcttat aggtctgatt gcagttagga taatgtgagc atcccaaaaa cttgacgctg      840
gtattttgat tttgtctggt gaccagcttg cctgttttgc agtctgctat aggaatagct      900
tttcttgttg aaaacgtaga agtttattaa taatttgaat aaaaaaagtc ccaccgaagc      960
aggactaaag atttttatct acggcatata gccttattgt gataagatta aagattagaa     1020
attttaatca gttacaaata tatataaaaa gtattatgat agaaaaagga aaaccgtaat     1080
tgtcttattt ttttttatag taaattccgt gcagattaaa tttaagaaat atggcaaaga     1140
ttttaggatt agatttagga actaactcga taggttgggc attaattgac gataaattaa     1200
ataaaatttt agggattgga agtagaattt ttccaatggg ggttgaaaat cttggtgatg     1260
gcgataacga aatgtctaag aatgcaagtc gaacaggagc aagaggagtt cgacgtcagt     1320
tttttagacg aagactaaga aagaaagtgt tactaaaatc actttctgaa aataatatgt     1380
gtccaataaa caccaaagat tttgaagatt ggaaacaaac taaacagttc cctaatgaaa     1440
aattagcaac ttggtttgct atgaatcctt atgaattgcg tcaaaaagca ttgacggaaa     1500
aattatcttt agaagaaata ggtagaattt tttatcatct aattcaaaga agaggatttt     1560
taagtaatag tagaaaagga ggaagcgatg atggagctat ttttaaagga aatgctaaag     1620
aaggaaaaat aggaattgat tatactttag aaagtatcga aggaaaaaca ttgggttcat     1680
atttatatga gatttatcca aaagaaaatc agccttttca atatggacta gaaagaatca     1740
gaaacagata tacaactcgt agaatgtata ttgacgaatt tgaaatgatt tggaataaac     1800
agtcagaatt tcattcggtt ttgaattatg atttaaaaac aattttaggg ggtagaaaac     1860
aagataatta cacagaagac ggtattttat tttatcaaag acctttgcgt tctcaaaaac     1920
atttagttgg aaactgttct tttgagcctt taaaaactaa atgccctata agtgctattc     1980
ctgtagaaat gtttagaatt tggcaatggg ttaatacagt tgaatataat gggaagaaaa     2040
tatctgaaga agaaaaaacc aaactagttg agcaattgct ttcattcgat aaaattgaat     2100
ttaaaaaact ccgaaaagct attgggaaag aaagtgcgga gtttaagttt aattacaaag     2160
acgatgataa aattgctggt acacatacta tctctaattt atccaataga aaattctttg     2220
gcaaaagatg gtttgatttt tcagataaag agcaagaaga tatttggcat gttctgtatt     2280
tttttgatag caaatcaaac ctaaaagaat atgctgttaa gaattggaat tttagtgaag     2340
aacaagcaat tgcaatttca aggtttaatg taaaagacgg ctatgctagt ttgagtcgaa     2400
aagctattgg aaatattttg ccttttttgc agcaagggta tacttatgat attgcagttg     2460
ttatgggcgg aattaaaaat gcttttggtg acaaatggca aaatgacaca gtagaaaata     2520
agctaaaaca actagatttg attgataata ttgaaggtat agttaggtct aaaatttcag     2580
gaggatttat agatacaatt aaggatttat tacgtaaaga atttgaattt aatgacaaac     2640
aattaaaaaa actttaccat cattctgctg caattgatac ggtagcatta ttacgaaaac     2700
tgccaactgg gaaacaggca gataaggata ttcaagctat tagaaatcca attgtaatta     2760
cagctttatt cgaattacga aaattggtca atgaattaat cgaagagcat gggcagcttg     2820
acgaaataaa agtagaaatg gcccgtgacc tgaaaatatc aaaatcgcag cgaaataaga     2880
tacgcaaaga tcaaaaacga ttggagagag aaaatgacag agtaaaaaag gaagtagaaa     2940
agtatgtaag agtttctcat gataacattc taagatttaa gctttgggag gaatgcaagc     3000
agacttgtcc ttatacaggt gttgtaattc cagtcacaaa actttttaca ggggaaatac     3060
aaatagagca tatccatcct tggagtcgtt cgttaaacga tagtttcaat aataaaacat     3120
tgtgctatgc ggatgaaaat agacgaaaag gagacaaaac accttttgaa ttttatggaa     3180
gcgatgagct ggattggatt gctagaaaag aacgtgcttt aaaattgttt tctgatacta     3240
aagagtatcc caatgcctat caaaaattca agcgatttgt acagcaaaaa tttgacgatg     3300
atttttcttc aagacaatta aatgatacac gatttataag taaagaagca tcgtcttatt     3360
taaaacaaat atgtgaaaag gtaaatgttt ctccaggtca aatgacagct aacttacgtc     3420
aaaaatgggg tttgaatacg gttttgaatg atgaaaatgc taaaactcgg gaagaccatc     3480
gtcatcatgc tattgatgct ttggttatgg catgtgggaa gacaagttat ttacaggaat     3540
tgtcaaaatg gaatcgttac aatagaaatt atgatttaaa agattttcct atgccttggg     3600
aaactttccg atttgatgct gagaaagcaa ttgataaaat attgatttcg cataaacgta     3660
tttctaatga tattacaact cgatatacta aagtggaaaa aaacggaaag acatatataa     3720
ataagggagt tgcagcacga gggcaattgc ataaggaaac tgtttttggt aaacgaaatt     3780
ttaatggaga tgaagcattt catgttagga aatcaattga tagtttaaca actgagaaac     3840
aattagaaaa agtggttgat gaagttatta aaaaattaat tcataagaag attaaggaat     3900
tgggaggatt cgtaaaaggt actatccctg ctaatacttt tttcaatgtt gatgaaaatg     3960
gagttaaaca accacaaatt ttcctgccaa ataaaaatgg tagtccagtt ccaattttaa     4020
aagtccgaat gaaagaaaat attagtggag ctgaaaaatt aaaagacaat gtcaatcaat     4080
gggtaaaccc tagaaataat catcacgtac ttatttataa ggatgaaaaa ggaattttaa     4140
gggaagaagt ggtgactttc tggactgttg ttgaaagaaa aagtaaagga tttccagtgt     4200
atcaattacc agttgaagga aaagagatag tgacagcttt gcatattaat gatatgtttt     4260
tgttaggatt aaatgaagaa gaaatcaatt gggagaatcc agattatgag attctaagag     4320
atagtttata tagagttcaa agtttgtctt caaaatatta tgagtttagg cagtctatta     4380
atgcagaatc tcaaaataaa atttcaccta tttatgaaca aattagagga tttggttcgg     4440
gtaaaaccgg ttgggattct tttaatccaa taaaagtaaa aatttcagtt tcaggaaaaa     4500
tttcaaaaat ataattttac tttaaaaaat agtgtaaatg ctatcaaatc aaaggagatg     4560
aaaagataga gattattacc attataggaa gacaagattt tgataatagt tctttgacat     4620
aattcaaatc ttaaacatcc aaaccacaac gaaaaggtat ggcattcgcc cagcaggaat     4680
gcggtgaaag cagttgtggt ttgattaaag attagaaaac acgatattcg atgatgatat     4740
tgttttaggt ccataccggt tgtggtttga ttaaagatta gaaaatacga tattcatcat     4800
agtatgagtt gtaagaagtt ccagttgtgg tttgattaaa gattagaaaa cacgatatta     4860
aaatccttta gcgccttcaa tttcaagctg ttgtggtttg attaaagatt agaaaacacg     4920
atattattat attcttataa cgatccgatt gatatgttgt ggtttgatta aagattagaa     4980
aacacgatat tatgatttca attgtttaat attgttgggt cgttgtggtt tgattaaaga     5040
ttagaaaaca cgatattcct ttgtcgttga ttgtttccaa agactcgttg tggtttgatt     5100
aaagattaga aaacacgata ttccatgtta tccgatatat tcgatgaaat agttgtggtt     5160
tgattaaaga ttagaaaaca cgatattcag gacttgttcc aaaagcatca tcgctggttg     5220
tggtttgatt aaagattaga aaacacgata ttgggcacag acagctgtta acgctagata     5280
tagttgtggt ttgattaaag attagaaaac acgatattga cattgtttac ctaacactaa     5340
agggaaatgt tgtggtttga ttaaagatta gaaaacacga tattacggtg aaagttatgc     5400
gaaataattt aggagttgtg gtttgattaa agattagaaa acacgatatt ttggtgaata     5460
aagacgatga atttgaaatg gttgtggttt gattaaagat tagaaaacac gatattgact     5520
tagtaaaaga ctctacgcca ttcgcagttg tggtttgatt aaagattaga aaacacgata     5580
ttttgatgat ggtaaatgat ggatcggggc ctgttgtggt ttgattaaag attagaaaac     5640
acgatattgc tctcaacaac ttcttcccat ttgactagtt gtggtttgat taaagattag     5700
aaaacacgat attaaagata gaagctatgt gtacaattgc agagttgtgg tttgattaaa     5760
gattagaaaa cacgatattt ctttataaat ttcaatcctt gtatccgtgt tgtggtttga     5820
ttaaagatta gaaaacacga tattgaagtc aatcggtgta atttctttct gttcgttgtg     5880
gtttgattaa agattagaaa acacgatatt ctaacgcatt tctcaacaga ttaccattag     5940
gttgtggttt gattaaagat tagaaaacac gatattataa ctaactttgg gtcaaatcta     6000
aagacagttg tggtttgatt aaagattaga aaacacgata ttacatcgta ataagagtta     6060
tacgaacttc cagttgtggt ttgattaaag attagaaaac acgatattcc aacagcgcca     6120
acagcaacag caggaacgtt gtggtttgat taaagattag aaaacacgat attttatttg     6180
agttgtcaac tcaatgaatt tagttgtggt ttgattaaag attagaaaac acgatatttt     6240
aattaattta gtttttcata ataatctcgt tgtggtttga ttaaagatta gaaaacacga     6300
tattccgaat ccagaattaa tgagaaaatg cgtgttgtgg tttgattaaa gattagaaaa     6360
cacgatatta gaatacttgg tttaatcgag ttatgctaag ttgtggtttg attaaagatt     6420
agaaaacacg atattgatat gtttttagct tttggattga ttgctgttgt ggtttgatta     6480
aagattagaa aacacgatat ttccatattc aagaggatat tcttttgatc cgttgtggtt     6540
tgattaaaga ttagaaaaca cgatatttaa agctaaaatt agtgaaagca ggacttggtt     6600
gtggtttgat taaagattag aaaacacgat attaaaagag ccaataataa tgacaaagga     6660
aaagttgtgg tttgattaaa gattagaaaa cacgatattt acaccgaaag cagtaaaaat     6720
ttagaaactg ttgtggtttg attaaagatt agaaaacacg atatttaaaa atttaattat     6780
gaaagggaat tatttgttgt ggtttgatta aagattagaa aacacgatat taagtgaact     6840
gtttgactta agaaatgctg tgttgtggtt tgattaaaga ttagaaaaca cgatattaag     6900
gcaatttaga ctaattgcga gtccagcgtt gtggtttgat taaagattag aaaacacgat     6960
atttggtcac ctttccaacg caaatgttta acagttgtgg tttgattaaa gattagaaaa     7020
cacgatatta agacgtttag tattggtgcc aagcggattg ttgtggtttg attaaagatt     7080
agaaaacacg atatttctat ctgaaatgat gatgacgctt tttagttgtg gtttgattaa     7140
agattagaaa acacgatatt aatgcatcag taagcatata tgatacttct gttgtggttt     7200
gattaaagat tagaaaacac gatattaaac atatccaaga tcattattaa ccctatgttg     7260
tggtttgatt aaagattaga aaacacgata ttttgataac aattaaaaag atagattcta     7320
aagttgtggt ttgattaaag attagaaaac acgatattac ggtctaacat catacaaata     7380
actacttagt tgtggtttga ttaaagatta gaaaacacga tattttgaat tatttcgttt     7440
atcagtccac tgtagttgtg gtttgattaa agattagaaa acacgatatt ggtaacataa     7500
aaacaaatac catcgttatt gttgtggttt gattaaagat tagaaaacac gatattcggt     7560
tcgtttatta acagtttaac aggcaagttg tggtttgatt aaagattaga aaacacgata     7620
tttttaaaaa ttgatggaac agttacgctt gcgttgtggt ttgattaaag attagaaaac     7680
acgatattga gtacagtagc tttaggtgca tacaatgcgt tgtggtttga ttaaagatta     7740
gaaaacacga tatttgattt ttaagattgt ttatctcacg ttccgttgtg gtttgattaa     7800
agattagaaa acacgatatt aatgcagaaa attcattgag aatgactgcg ttgtggtttg     7860
attaaagatt agaaaacacg atattcgaca acctgagtat ctaaaaccaa tacttgttgt     7920
ggtttgatta aagattagaa aacacgatat tagttggctt ttttccttct gatatataag     7980
tctttaggtg taaatatcgt tcagaaaaat gcctctttta tggcctgata acccataatt     8040
gaggcatttt ttctattgta gggtttatta gataaggtct tgaatgttga aactttgcta     8100
ataattataa aagatcagtt ctagaataat tctagttgtg taggctgagg tgctgatggt     8160
aaggctgctt ttccccaaaa atttaagata ttaccaaatt gcttatccgt tattcgaagt     8220
a                                                                     8221

<210>  22
<211>  5908
<212>  DNA
<213>  Artificial sequence

<220>
<223>  CRISPR-Cas Locus 27

<400>  22
acgtgtggtg gcattcggca ccttcacctc gaaaggcaaa cgacgctcat cagcaatgtg       60
cagcatgagc aggcgaattg cgtcggagat ggacaagccc gtcgcttcca gcacatcggc      120
ggcgcgctcc ttggtagcgc tatcgatgcg agcgcgaacg taggtatcga cggtgctcat      180
ggcgatttcc ttggagcggt tcctataact ccatcgtggt catattgcgc ctatatatca      240
aggtatgtgc cagcctgatc catatcttaa cggccagagc agtatttcaa agcctctacg      300
caagctgcgc cgattcgctg tctcgccggc cgtctttgac ggcctgagtc agtagatggc      360
ttgcgttgcc ctccgagctc acataacgcc cagcagccga aacaaagaca gtttcgtggc      420
acgacctaca gaaaagaaaa acggtcaccg agatgaccgt ttgtatcggt tggcttcgta      480
ccgaggtact tagccttgtt gccgatagtc cccaccatcg gaatgactga tacgctttaa      540
aagataagtg acttgtatcg acagggcaag gccatggcat acaaattagg aatagatctg      600
ggcaccgcgt ccattggtgc tgtcgccatc cgcatcgaaa acaacgaacc acaaagcatt      660
gactggcatg cagtacgcat ttacagcgaa ccagttgtaa acactccgaa agggctgcaa      720
cccaaaaagg cggcccgccg tgacgcacgg caattgcgca aacagattga aaggcgagca      780
cgacggttgc gccgcattgc caatctgatt ccattgctgg gattgcataa agccgaagtg      840
aaaccggggc gccgtcagga tttgaccaca ttgcgcgcca tcgcagcgcg ccagcaggtc      900
gagctaaacg agtttgccct agtactgctg cgtctggcca aacgccgtgg ttacgccggt      960
ggatttcgcg attccaaaga cggtgtagtc aagagctcca gcgacaaact gagcgaggaa     1020
atgagacgtc ttgccgagac gcaaaacctg caggaaataa ctctgggtga atacctgctg     1080
tacagacagg aacacggact gcctgtctgg ctcaaagccg aacgtccagg tctggaaccg     1140
cgctatgccc tgcgcgaaat ggtaaccgcc gagttcgaac agctctggac aacccaggcc     1200
cgataccacc cgatcctggc ctctaatcat ctcggcaagc cacttaagca atggttcaat     1260
gaagcgctgt tctaccagcg gccactgaag tctcccgccc acatggtcgg caattgcctg     1320
cttgagccca atctgccacg tgccccacgc gctcacatgg cagcccaaca cttcagaatc     1380
gataaaacgc tccatgacat gcgctggggt agtgggcgac gggctgaacg cctgagcaag     1440
gcacaactca acgtgctgcg tcagatgctg aatgatccag ccaatgccga tggcaaggtc     1500
agcttcaaac acctgtatca agctttgagc gagacagggt tgagcgatcc acgaagtcgc     1560
actttgaatc tggagcgcag cagctgtgat caactgtccg gtaacaacac ggttgctcgt     1620
tggcgtgcgt tgggactgta cgaccaatgg ctgacgctag cccctcgcga ccagacaacc     1680
atcatcaact tgctggcgga cttgggcggg ccggaactgc tggttccgga cgactggcac     1740
cagaacatcc gcaagagcag cgccaaagct ggcgatacca acctttatcg tcgattccgg     1800
cccgaggtcg ttgatttcat caatgcgctt cgcgagtgca aggacaacaa tgggcagcca     1860
gttttcaatc ggctgacatc tatgaagttc gagggcggac gcagcagcta ttccgtcaag     1920
gccttggaaa aattgaatac ctggttcaat gatccttggt ggcccgacga aggctcaggg     1980
gccgagcgtg gtgacgaaat cgatgaagac gcagcactac gggtctgcta tccacatctt     2040
tttacgcagc cccaagagct gctccaacga ctcgaggccg ctccgaccac gggcaacgac     2100
gtggttgacg gagccttgcg cgaattacgc aaggtcatca accaatgcat tgacgctttg     2160
ggtgagaggc cagaggaaat cgtcgtcgaa atggcacgag agatcggcaa gggcgtcgtt     2220
tggcggaaag agcaggaaaa ccgcatacgg cagaatgaac tcgcccgaag gaaaattgcc     2280
agcgaactgg aaaagcacgg actgagcgcc aacaacaccc ggatactgcg ctatcaactc     2340
tgggaagagc aggatttgca ctggtgcccc tactgcgccc atcccattaa tctggaagca     2400
gccacctcgg gcatgacaca catagagcac gtcctgccac gctcgctcac ccagatcggg     2460
cgcaaacgca gcgaactggt gctggcccac gccggttgca acaacctgaa agccgatcag     2520
acaccttggc aagcatttgg ccatgatgtc gagcgctggt ctgcagtaga acgcgctgcc     2580
gcccgttttc aagagctggg caagaagtct tacgccaagg accgcatcaa ggcgatgggc     2640
ttctaccgca aggcggaact tctcctgctg aaggattacg aaagcgaagt actgagcgac     2700
gaatccatag ccgacttcgc cgaccgccag ttacatcaga cctcctggat cgccaaggct     2760
gcagcccagt ggttgcgcac catcaccccg ctggtttccg tctctcgcgg tgaattcacc     2820
gccctactac gccatcaatg gcgactcgac accgtgatcg cagaagcgcg ccttgatgaa     2880
aaacttcctg ttctggatat cgatgcgtgc cccgtatctc cggaagcatt ccagcagttc     2940
cggaaacaat gggaagggca tccaccagac aacctggccg aacggaccga gcgcaaactg     3000
gaaaaacgcc tcgaccatcg ccaccacggc atagatgcct tggtcatcgc gctcaccagc     3060
cgaagcctct acatgtctct ggcccggcgc tacgttgaag aaagcgaaag gcgcgcccgc     3120
ggcgagagag tccggcatga ttggtccatc gagccgacta tgcacaatct gcgcaaccaa     3180
gcgctgggta tggtccgtac ttgcaacctg acccacaagc ctgaccgcaa cccagccggc     3240
cgactattca aggacaccgc ctatggcgtc cactttccag aggagggcga tcgggtacag     3300
ctgacgctgc gcaaaccttt gaccagcctg gccgacgaaa agtctgccga gaagactcgc     3360
aagaacctgc acagcattgc cagcagtgag gtacgcctac tcgttctgaa agcattcgaa     3420
gcgcgcctca gtgtcgggca gaatccgaaa caggcgctct ccgaaccggt accctacccc     3480
gcctatggca ccgcaatctg gcgagtccgc tgcatgcaag gctacgcgga cgatgccgtc     3540
cgtattgtcc ataaaagccg tcagggcgaa cacgaaaagc acctgctcaa cgatggctat     3600
gcctgcttgg aaataaccgc tggggaaaat ggcaaacacc aagtacgcct tgtcactcag     3660
cgtgaagcac aaggccgcgg cttcatggat aaccggcagc aggcgaaacg catattcaag     3720
ggagatacgg tgatcgaccg gcgcgacgac cgtaaatacc tagtgggcta cttcaaggcc     3780
gagggctata ttttcctcct cccccacacg gacacccgca acttcgacaa gatcaaggag     3840
gcggactcgg gcaagaagaa agtttccttc aaccaagcgt accaacttga gcgcatctag     3900
ccatgtccga gcaccgggta ttgctcatcg aacatcaggc ctatctgagc atcgacctag     3960
ggcgtctgtg tatccgccga ccacagcagg agagcgtgtt cgtcctgccc gctgacattg     4020
ccgtgctctg cctgcaccac ccggccatca cggtaacggc ccacaccctg cagaccctga     4080
gccaggaagg tgcgatcgtc ttggtgacgg acgaccaaca tctaccgctg gcccaggtct     4140
accccctgct cgcccccatg cgtcagacac tgcggctgct ccaacagttc gagctgcaag     4200
agtcgccgtg gcgcggcatc gtctggcaac gcctagtgca agctcgcctg cggggcgaag     4260
ccgccgttct gcgcagtttg ggcaagaaag gcacgctttt cctagagcga ctggccaaca     4320
aagtgcaacc gggcgacagc gaccaatgtg aaggccaagg cgcccgccac tactggaaac     4380
acctgctgcc tgagggtttc cggcgcagca agcagggtgc caccgacctg ctgaatgctc     4440
gcctcaactt cggttatgcc gtgctgcgct cgctgatcgc gcgcaacctg gcttgtgccg     4500
gccttaatgg ttgcttgggc gtcggccact gcaaccagca gaaccccttc aatttagccg     4560
atgacttgat agagccttac cgcttccttg tcgaatggcg ggtcgcgcgg caactcgagg     4620
agcatgggga gcaacctttc gatgcggcta gccgcaagag cctgttgcag ttcatgtccg     4680
acaccatccc catgctgcta ggggactacc gcctgcctgc agcgatagct gccactgtcg     4740
acagctgggt gcagacactc gacgcaattc atgcgcaccg gcatccaggt acgataacgc     4800
taccggagta tgaacgatgg ccattaacgg atggcgggtc atgtgggtga tcgccgttta     4860
cgactgcccg atgaccagcg cagaagcccg gcacggctat gcgaaattcc gaaagtcact     4920
gctgcgggcc aacttcatcc aactgcagaa ctcgctctac gtccgccact ttccgagcat     4980
ggcgacggcc gaggcttgca ttgctcgttt gcggtacgac attcccgaac gggcgcaact     5040
ggcgttcttt cttgtcaccg acaagcagta cgctatgact cgggagtatt tcggcgaatg     5100
cagcgtacgg aaaaagccag aggccccgga gcaaatcgag ctgttctgaa aaaaagcgca     5160
accctaacaa tgggttgcgt gatcaagagg ttatcagtca ttccgatggt ggggtatcgg     5220
aacatccgca gctacctgcc gcaagacggc tggaggttat cagtcattcc gatggtgggg     5280
tatcggaaca cacggtgatc tttgccgaac cgactggcta ggttatcagt cattccgatg     5340
gtggggtatc ggaacattca ggacatccac gaagactacc cgggcaggtt atcagtcatt     5400
ccgatggtgg ggtatcggaa ctgcgcgcct acggcaatgc cgtcaactcg caggttatca     5460
gtcattccga tggtggggtt atcggaactt ggcctgatcg ctggtggcac cgaaggaaga     5520
aggagtacac atgaagcttt gtgcgcggaa aatgctgtaa caaaactcgg gtatcgacta     5580
tgcgaccgga tacctagttt tgagatttta cgtttccata ctgactactt atcggttacc     5640
tgagtgatta tttgcttgct atttattcgc ttgtttaaac gagcagccag agtagcgctg     5700
atagcaatac cttttctcga actcgatagt cggttaaaaa ccctcaagac attgattaca     5760
ttaaaaatta ttaaaacagc cacaaacaga ctcgcgaaga ccttgcctta taaacaagtc     5820
actaagtcaa ccaagaatac ttagcgactt aatttttgag ggttttcgat gcgagttatt     5880
ctcacttaga aagttttcgt ttttttag                                        5908

<210>  23
<211>  6265
<212>  DNA
<213>  Artificial sequence

<220>
<223>  CRISPR-Cas Locus 28

<400>  23
catgtgacgt gtagaagtat atccaaatca ctcccgattt cctcagccca ttggcactgc       60
ctgaacactc tgtatggagc cgcgagggta agcaggcgtt gcgctggggg aatgttcact      120
gcgcgctgga agcggtcgaa gaataccctg gtcatttcaa acaaggccag actcggttta      180
agggtacgga ccttggttag tgacagctgt caaaagtcga cttcatagtc gccttcggca      240
atcctaatga tggctattat aaatttcgaa accagtctct tttttgcaaa ccgtgttgct      300
tcgacggtgc acggcggcca aaactgacac ccaaaaaaca aaaacggcca ccgaggtggc      360
cgtttgtatc ggttggcttc gtaccgaagt actcagcctt gttgccgata gtccccacca      420
tcggaataac tgatacgctt tttgaagata aagcacttca ggtgacaggg caagataatg      480
gcatacaaat taggtatcga tctgggcacc gcttccatcg gtgcggttgc cattcgtatt      540
gaaaataagg tgcctatcag cgttgactgg catgcagtgc gcattttcag cgagcccgtc      600
gtaaacactc agaaagggct cacgcccaaa aagacggccc gtcgtgaagc ccggcaattg      660
cgtaaacagg tcgaacgacg agcccgacgg ttgcgccgta ttgccaatct gattccattg      720
ctggggttgc agaaagccga agtaaagctt gggcgccgtc aggacttgac cacgttgcga      780
gctattgccg cgcgcgagaa ggtcgaacta catgagtttg ccctggtact gctgcgtatt      840
gccaaacgcc gcggttacgc cggtggattt cgcgattccg aaggcggcgt ggtcaagact      900
gccagtgaca aactgagcgt ggaaatgaga gctcttgccg agacgcgagg cctgcaacag      960
ataactctgg gcgaatactt actgcatcga cagcaacgag ggctgcctat ctggctcaaa     1020
gctgagcgtc caggcttgga accgctctat gctctgcggg agatggtaac cgccgaattc     1080
gaacaaatct ggacaatcca agccaaatgc catccgatcc tgaacagctg tcatctcgaa     1140
aaaccactta agcaatggtt ctatcaagca ctgttctatc agcgaccact gaaatctccc     1200
gcccacatgg tcggcaattg cctgcttgaa cccaatttgc cacgcgcccc acgcgctcaa     1260
atggcagccc aacgcttcag gatagaaaaa acgcttcacg atttacgctg gggtggcgga     1320
cgacaggctg aacgcctgaa cacagcgcaa ctcgacctac tgcgtcagac tctgagcgat     1380
ccaaccaatg ttgatagcaa ggtcagcttt aagcgcctgt accaagccct gaacgaggct     1440
gggttgaacg atccgcgaaa tcgcacatta aacctggagc gcagcagtcg cgatcagtta     1500
cttggcaata gcaccgttgc ccgttggcgc gcgctgggcc tgcaagatca atggctgatg     1560
ctggctcctc gcgaccagac atctgttatc aacctgctgg cagacttggg tggtccggaa     1620
atactgaccc cagacgactg gcaccagaac atccgtaaaa gcagtgccaa ggacgacaac     1680
accaaagcct atcgtcgatt ccggcaggaa gttattgatt tcatcgatgc gcttcgccgg     1740
tgcatagata gtaatggcca gccggttttc aatcgtcttt ccgctatgaa gttcgacggc     1800
ggacgcagta gctactcggt aaaggccttg gaaaagatga acgaatggtt caataacccg     1860
tggtggccca atgaaggtcc aggctcagag cgtcgcggcg agatcgacga agaagtggcg     1920
atacgggtgt gttacccaca tctttatacg caatctcaag agctgcaccc gcgactcgaa     1980
gccgctccga ccaccggcaa cgacgttgtc gatggagcat tacgcgaact gcgcaaggtc     2040
atcaaccaat gcattgacga gcaaggtgag aaaccacagg aaatcatcat cgaattggca     2100
agagaggtcg ggaaaggtgt ggctttgcgg aatgaacagg aaagtcgcat tcggaacaac     2160
gaactcgcca ggcggaaaat tgccagcgaa cttgaagggc acggtttgat tgccagcagc     2220
acccggatac tgcgatatca actctgggag gagcaagagc gacactggtg tccttattgc     2280
gcacttccca tcagcctgga agcagccatc tcaaacatga cgcacataga acacgtcctg     2340
ccccgttcgc tcacccaagt cggtcgaaaa cgcagtgaac tggtgctagc ccatgctggt     2400
tgcaatcatc tgaaagccga ccagacgcct tggcaagcct tcggccacga tgccgagcgc     2460
tggtctgcag tagaacgtgc tgccgcccga tttcaggagc tgggtaaaaa gtgctatttc     2520
aaagacaggg cgaaggcgat gggttgcttc cgaaaatcag cccttctcat gctgaaggat     2580
tatgaaagtg aagtattaaa cgacgaatcc atagccggat tcgccaaccg tcagttacac     2640
cagacatctt ggattgccaa ggttgcagcc caatggttac gtacgatttc accgctgata     2700
tccgtttccc gcggcgaatt caccgccctg ctgcgccatc aatggcgact agacaccgtt     2760
atcgcagaaa cgcgctatgg tgaaaaactt cccgttctgg atatcgatgg caatcccgtc     2820
catccggaag aatttcagca cttccggaaa caatgggaag gacatccacc ggacaacccc     2880
gccgaaagaa ccgagcgcaa actggaaaag cgcttcgacc accgccacca tggcattgat     2940
gccctggtca tcgcgctcac cagccgtagt ttgtacatgt ctcttgctcg gcgctatgta     3000
gaagaaagca aaaagcgcgc ccgcggcgag aaagtccggc gtgactggtc cattgagcca     3060
cctatgcaca atttgcgcgg ccaagctctg gatatgatcc gcgcgtgcaa cctgaccctc     3120
aagcccgacc gcaacgctgc cggccgactg tttgaggact acgcctatgg cgtccacttt     3180
tctgacgcaa gcgagcgggc acagcttacg cggcgcaaaa cattgataga tcttgcagac     3240
gaaaagtccg cagagaagac tcgcaaaaat ctccagagca tcgcaagccc tgaggtacgc     3300
cagatcgttg tggaagcgct ccaaatgcgc ctaagtgccg ggcaaaatcc gaaacaggcg     3360
ctctccaaac ccgtactcta ccccgcttac ggtacagaaa tttggagggt ccgttgctta     3420
caaggctacg cggaccatgc cgtgcgaatc gttcacaata gccgccaggg tgaacacgaa     3480
aagtgtctgc tcaacgatgg ctatgcctgc ctggagataa gggccgggga aaatggcaaa     3540
caccaagcac gtctcgtcac tcagcgggaa gcacagggtc gtgacttcat ggaaacccag     3600
cagcaggcga agcgcctatt caagggagat acggtgatcg acaggcgcga tgatcgtaaa     3660
taccgagtgg gttatttcac cgccgagggc aatattttcc tcatcccctt cgaggacact     3720
cgtaatttcg ataaaatcaa tgagcggaac tcgggcaaga aaaaggtttc cttcaaccaa     3780
gcgcatcgac ttgagcgagt atgacgatgt ccgagcacag agtactgctc attgaacatc     3840
aagcctatct gagtattaat ctagggcgcc tgtgcatccg ccgaccacag caggagaacg     3900
tatatgtcct gccctcggac attgctgtgc tctgcttgca ccatccggct ataacgttaa     3960
cggcccagac attgcagatc ctgagccaag aaggcgctat cgttttggca accgacgata     4020
aacatcaacc acttgcacag gtctaccccc tcctcgcccc catgcgtcaa acactgagac     4080
tgctgcaaca attcaaactg caagagtcgc catggcgggg catcctctgg caacgattag     4140
tgcaagcccg cctacgggga gaagccgccg ttctgcgcag cttgggtaag aaaggcgctc     4200
tatttcttga acgactggcc atcagggtac tcccgggcga cagctgccaa tgtgaaagcc     4260
aaggtgcccg tcactactgg aagcacctgc tgcctgaggg ttttcatcgc agcaagcagg     4320
gggctatcga tccgcttaat gtccgcctca acttcggcta tgccgttctg cgttcactga     4380
tcactcgcaa cttggcttgt gctggcctga atggttgctt gggcgtgggt cactgtaacc     4440
aacagaaccc cttcaatctg gccgatgacc tgattgaacc ttaccgcttc ctcgttgaat     4500
ggcgggtggc acgccaactc ggtgagaatg ctcagctacc attcgatgca tcgactcgca     4560
agcaactgct gcaattcatg tccgacgccg tccccatgcc gcgaggggac taccgtctgc     4620
ctgcagcaat agaggccaca gtcgacagtt gggtacaaac actcgacgca attcatgcca     4680
accggaatcc aggcacgata acgctaccgg agtatgatcg atggccatta acggatggcg     4740
ggtcatgtgg gtgatcgccg tttacgactg cccaatgaca agcccagaag cgcggcacga     4800
ctatgcgatt ttccgaaagt cactgctgcg ggccaacttt atccagctgc agaactcgct     4860
ctacgtccgt cactttccga gcatagcaac agccgacgct tgcatttctc gtctgcgttt     4920
aaatattccc gatcgtgcgc agctagcatt ctttcttgtc accgataagc agtacgcaat     4980
gactcaggag tattttggtg aacgcagcgt tcggaaaaaa ccagaagccc cagagcaaat     5040
cgagctgttc tgaacaaaaa aacgcaaccc tggcaagagg ttgcgtaatt aagaggttat     5100
cagtcattcc gatggtgggg tatcggaacg ctgcggcaaa gataacttcg ctgtcataaa     5160
aggttatcag tcattccgat ggtggggtat cggaacacgg ccatggtggg tccgatacgc     5220
tttagcaggt tatcagtcat tccgatggtg gggtatcgga accgcgcatc tacagcaccg     5280
acgacgggtt ccaggttatc agtcattccg atggtggggt atcggaactg gtcattaccc     5340
cggaagccgg cgagcaggag gttatcagtc attccgatgg tggggtatcg gaacattcag     5400
cagtacatta aaaccggcca acacaggtta tcagtcattc cgatggtggg gtatcggaac     5460
taatcatggg cggcggtggc ggcggtggcg aggttatcag tcattccgat ggtggggtat     5520
cggaacgagc gaatgcagcg gtcgcgggtg cggatgaggt tatcagtcat tccgatggtg     5580
gggtatcgga actgccaccg tggcgcctgt cgttcgaccc gtaggttatc agtcattccg     5640
atggtggggt atcggaacgt agccgggcac gtcctgccgg gcttcgggag gttatcagtc     5700
attccgatgg tggggtatcg gaacacacgg tgcagaccaa aacgtggccc gccaaggtta     5760
tcagtcattc cgatggtggg gtatcggaac aatggcagac cgggcggcgc gcgctatttt     5820
aggttatcag tcattccgat ggtggggtat cggaacatcg ttaacgacga cctcggcgtt     5880
ttcgataggt tatcagtcat tccgatagtg gggtatcgga acaacgcaga gaccagcgag     5940
cagcgtattc gcaggttatc agtcattccg atggcggggt atcgaaacac caaaatgtac     6000
gacctgaaaa cattaggtca tggaaacatc aagcactccc agcatcacct cttgatagac     6060
ttactctctg agctagaaca accctcctaa ctcagccggt ttccaattca taattaccag     6120
ttccccgctc acatcagcct ttccctgccg ctggttggtg gcgctgtaac ggatatccag     6180
tcgctcgaag tgaaaacctt cgaacactcg gcgaatgtcg gggtgatcat tgatgctgac     6240
catcaccctg cccttgcagc ggcgc                                           6265

<210>  24
<211>  3282
<212>  DNA
<213>  Bacillus cereus

<400>  24
atggcataca caatgggaat agatgtgggg attgcttcgt gtggatgggc tattgtagat       60
cttgaaagac aacgaataat agatctaggt gttcggactt ttgagaaagc agagaatccg      120
aaaaatggag aggctcttgc tgtaccaagg agagaagcta gatcgagccg taggagatta      180
cggagaaaaa aacatcgcat tgaaagatta aagcatatgt ttattcggaa tggactggcg      240
gttgatattc aacatcttga gcagcagacg ttacgtagcc aaaatgaaat agatgtatgg      300
caattacgag tagatggttt ggatcgaatg ctaactcaaa aagagtggct tcgtgtatta      360
attcatcttg cacaacgtcg tggttttcaa tcaaatcgaa aaacagatgg ttcaagtgaa      420
gatgggcagg ttcttgtaaa tgtaacggag aatgacagat taatggaaga gaaagattat      480
cgaaccgtag cggaaatgat ggtaaaagat gaaaaattct ctgaccataa gcgaaataaa      540
aatggaaatt atcatggagt agtgagcaga gcttctttat tagttgaaat acatacatta      600
tttgaatccc aaagacagca ccataatttt ttggcatcga aagatttcga gctggaatat      660
gttaatattt ggtcttcaca acggcctgtt gcaacaaaag atcaaataga aaaaatgatt      720
ggtacatgta ctttcttacc gaaagaaaag agaactccaa aggcatcttg gcattttcaa      780
tattttatgc tcttgcaaac gatcaatcat atccgtataa caaatataca aggcacgaga      840
tcattgaata aagaagaaat tgaacaagtg gtcaatatgg cacttaccaa atcaaaggta      900
tcttaccatg atattagaaa agtccttgat ttatcagaag aatatcaatt tgttggcttg      960
gattatggaa aagagaatga aaaaaagaaa gttgaaagta aggaaacgat catcaaatta     1020
gatgattacc ataagttaaa taaaattttt aatgaagtgg aattagctaa aggagaagct     1080
tggaaagctg ttgattatga tacagtagcg tatgctctca ctttctttaa agatgatgaa     1140
gatattagag attatttgca aaataaatat aaagatagta aaaatcgtct tgttaagaac     1200
gtagctaata aagaatacac aaatgaattg gtagaaaaag tgagtacgct atcttttcgt     1260
aaagtggggc atttatcatt gaaagcctta cgaaagatca tcccgttttt ggagcaaggc     1320
atgacctatg ataaagcgtg ccaagcggct ggttttaact ttcaaggtat atcaaaaaag     1380
aagagatctg ttgtcttgcc ggtcattgac caaatttcca acccagtagt aaatcgtgct     1440
cttactcaaa cgcgtaaagt aattaatgct ctaatcaaaa aatatggttc acctgaaacc     1500
atacacattg aaacagcaag agagttatca aagagatttg atgaacgaaa gaatattact     1560
aaggattata aggagaatag agacaagaac gaacgtgcaa aaaaacactt atcggaatta     1620
gggattatta atcctactgg tcttgatata gtaaagtaca agctgtggtg tgagcaacaa     1680
gggcgctgta tgtacagcaa ccaacccatc tcctttgaaa gactgagaga atcaggttat     1740
accgaggtag atcacattat tccatacagc cgaagtatga atgatagtta taacaatcgc     1800
gtattggtta tgactaggga aaatcgtgaa aagagtaatc aaactcctta tgaatatatg     1860
ggtaatgata cgcaaagatg ggatgagttt gaacaaagag tcacaacaaa tccacaaata     1920
aaaaaggaga aacgacagaa cctcttgcta aaaggattca ctaatcgtcg ggaattagaa     1980
atgttagaaa gaaacttaaa tgatacacgt tatataacta agtatctttc acattttatt     2040
agtacgaatt tggaattctc tcctagtgat aaaaagaaaa aggtagttaa tacaagcggt     2100
cgtatcactt cccatttaag aagtagatgg ggattagaaa aaaatcgtga gcaaaatgat     2160
ttacaccatg caatggacgc ggttgtaatt gctgtcacct cagactcgtt tattcaacag     2220
gtaacgaact actataaacg gaaagaaaga agagagttga atagggatga taagttccct     2280
ctaccttgga agttttttag agaagaagtc atagcaagat taagccctaa tccaaaagaa     2340
caaattgaag cattgcccaa ccatttttat agcgaagatg aacttgctga tcttcaaccg     2400
atttttgtgt caagaatgcc caagcgtagt ataactggag aggcgcatca ggcacagttt     2460
cgccgagttg tgggtaaaac gaaagagggt aaaaatatta ctgcaaagaa aactgcttta     2520
gttgatatta gctatgataa aaatggtgat tttaatatgt atggaagaga aacagatcct     2580
gctacttatg aagcaattaa agaaagatat ctcgaatttg gaggaaatgc taaaaaagca     2640
ttttcaacgg atttacataa accgaaaaaa gatggcacca aagggccact gataaaatct     2700
gtgagaataa tggaaaataa aacattggta catcccgtaa ataaaggaaa aggtgttgtg     2760
tataacagct ctattgtaag gacagatgta tttcaaagaa aagagaaata ttatttacta     2820
cctgtgtacg taacagatgt aaccaaaggg aaactaccaa ataaggtgat tgttgctaaa     2880
aagggatacg atgattggat tgaggttgat gatagcttca catttttata cagtctatat     2940
ccgaatgatt taatattcat cagacaaaat ccaaaaaaga aaatatcatt aaaaaaacgt     3000
attgagagtc attctatttc tgatagtaaa gaggttcaag aaattcttgc ctattataaa     3060
ggggttgata gttcaactgc tgctatagag tttattactc atgatggtag ttactatgca     3120
aaaggtgttg gtgtccaaaa tctagattgt tttgaaaaat atcaagttga tactctgggt     3180
aattattcca aagtgaaagg agaaaaacga cttgagttgg agacatctga taataacgac     3240
aaaggcaaag atgtcaattc gattaaatca actagtcgtt aa                        3282

<210>  25
<211>  3279
<212>  DNA
<213>  Brevibacillus laterosporus

<400>  25
atggcttaca caatgggact agatgtgggg attgcttcgt gtggatgggc tattgtagat       60
attgaaagac aacgaataat agatgtaggt gttcgaattt ttgagaaagc agagaatccg      120
aaaaatggag aggctcttgc tgtacctagg agagaagcta gatcgagccg taggagatta      180
cggagaaaaa aacatcgcat tgaaagattg aagcatatgt ttattcgtaa tagactggcg      240
gttgatattc agcatcttga gcagacgtta cgtagtcaaa atgaaataga tgtatggcaa      300
ttacgagtag atggtttgga tcgagtgtta actcaaaaag agtggcttcg tgtattaatt      360
catcttgcac aacgtcgtgg ttttcaatcc aatcgaaaaa cagatggttt aaatgaagat      420
ggacaggttc tcgtaaatgt atctgagaat gagagattaa tggaaaagaa agattatcga      480
accgtagcgg aaatgatggt aaaagatgga aaattttccg accataagcg aaataaaaat      540
ggaaattatc atggagtagt gagcagagct tctatattag ttgaaataca tgcattattt      600
gaatcccaaa gacagcacca taattttttt gcatcgaaag atttcgagct ggaatatgtt      660
aatatttggt cttcacaacg gcctgttgca acaaaagatc aaatagaaaa aatgattggt      720
acatgtactt tcttaccgaa agaaaagaga gctccaaagg catcttggca ttttcaatat      780
tttatgcttt tgcaaacgat caatcatatc cgtataacgt atttacaagt cacgagatca      840
ttgaataaag aagaaattga acaagtggtc aatatggcac ttaccaaatc aaaggtttct      900
taccatgata ttagaaaaat ccttgattta tcagaagagt atcaatttgt tggcttggat      960
tatggaaaag aggatgaaaa aaagaaagtt gaaagtaagg aaacgatcat caaattagat     1020
gattaccata agctaaataa gatttttaat gaagtggaat ttgctaaagg agaaacttgg     1080
gaagctgttg attatgatac agtagcgtat gccctcactt tctttaaaga tgatgaagac     1140
attagagatt atttgcaaaa taaatataaa gatagtaaaa atcggcttgt taagaactta     1200
gctaataaag aatacacaaa tgaattgata gaaaaagtga gtacgctatc ttttcgtaaa     1260
gtgggtcatt tatcattgaa agccttacga aagatcatcc cgtttttgga acaaggtatg     1320
acgtatgata aagcgtgcca agcggctggt tttgactttc aaggtatatc aaaaaagaag     1380
agatatgtcg tcttgccagt cattgaccaa atttccaacc cagtagtaaa tcgtgctctt     1440
actcaaacac gtaaagtaat taatgctcta atcaaaaaat atggttcacc tgaaaccata     1500
cacattgaaa cagcaagaga gttatcaaag acatttgatg aacgaaagaa tattaccaag     1560
gattataagg agaatagaga caagaacgaa catgcaaaga aacacttatc tgaattgggg     1620
attattaatc ctactggtct tgatatagta aagtacaagt tgtggtgtga gcaacaaggg     1680
cgctgtatgt acagcaatcg acctatctcc tttgaaagac tgaaagaatc aggttatacc     1740
gaggtagatc acattattcc atacagccga agtatgaatg atagttataa caatcgcgta     1800
ttggttatga ctagagaaaa tcgtgaaaag ggtaatcaaa ctccttttga atatatgggt     1860
aatgatactc aaagatggta tgagtttgaa cagagggtca caacaaatcc acaaataaaa     1920
aaggagaaac gacagaacct cttgctaaaa ggattcacta atcgtcggga actcgaaatg     1980
ttagaaagaa acttaaatga tacacgttat ataactaagt atctttcaca ttttattagt     2040
acgaatttgg aattctctcc tagtgataaa aagaaaaagg ttgttaatac aagcggtcgt     2100
atcacttccc atttaagaag tagatgggga ttagaaaaaa atcgtgagca aaatgatcta     2160
caccacgcaa tggatgcggt tgtaattgct gtcacctcag actcgtttat tcagcaggta     2220
acgaattact ataaacggaa agaaagaaga gagttgaatg gggatgataa gttccctcta     2280
ccttggaagt tttttagaga agaagtcata gcaagattaa gccctaaccc aaaagaacaa     2340
attgaagcat tgcccaacca tttttatagc gaagatgaac ttgctgatct tcaaccgatt     2400
tttgtgtcaa gaatgcccaa gcgtagtata actggagagg cgcatcaggc acagtttcgt     2460
cgagttgtgg gtagaacgaa agagggtaaa aatattactg caaagaaaac tgcgttagtt     2520
gatattggct atgataaaaa tggtgatttt aatatgtatg gaaaagaaac agatcctgct     2580
acttatgaag caattaaaca aagatatctc gaatttggag gaaatgctaa aaaagctttt     2640
tcgatggatt tacataaacc gaaaaaagat ggcgccaacg gtccactgat aaaatctgtg     2700
agaataatgg acaataaaac attggtacat cctgtaaata agggaaaagg cgttgtgtat     2760
aacagctcta ttgtaaggac agatgtatat caaagaaaag agaaatatta tttgttacct     2820
gtgtatgtaa cagatgtaac caaggcgaaa ctaccaaata aggtgatcgt tgccaaaaag     2880
ggatacgatg attggattga ggttgatgat agcttcacat ttttatttag tctatatccg     2940
aatgatttaa tattcgtcag acaaaatcaa aaaaagaaaa tatcattaaa aaaacgtatt     3000
gagagtcatt ttatttctga tagtaagaag gttcaagaaa ttctcgcata ttataaaggg     3060
gttgatagtg catctgctac tatagagttt attactcatg atggtagtta ctatgcaaaa     3120
agtgttggtg tccaaaatct agattgtttt gaaaaatatc aagttgatat tctgggcgat     3180
tattccaaag tgaaaggaga gaaacgactt gagttggaga catctgatag taaccacaaa     3240
ggcaaagatg tcaattcgat taaatcaact agtcgttaa                            3279

<210>  26
<211>  3213
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Cas endonuclease of Locus 8 (Cas-Locus 8)

<400>  26
atgagagagt tggattatcg catcggatta gatattggaa cgaattctat tggctggggt       60
gttattgaat tatcttggaa caaagataga gaacaatatg agaaagcgag aattgtcgac      120
aagggtgttc gtatgtttga taaggctgaa atacctaaga ctggtgcttc tcttgctgaa      180
ccgaggcgta tagcgcgctc atcacgtaga aggttaaatc gcaaaagcca gagaaaaaaa      240
gatatacgta atttacttgt tcaacatgaa attattagcc aaaaagaatt agcttcgtta      300
tatcctctgt caaaaagttc aatggatatt tgggatattc gtttggatgg attagatcgc      360
ttgttagacc gttttgaatg ggctcgacta ttaattcatt tagcacaaaa acgcggtttt      420
aaatcaaatc gaaagtctga actgaaagat gtggagacag gaaaagtatt atcaagtatt      480
caagcaaatg aaaaacgatt atctctgtac cgtacagtgg gagagatgtg gatgaagaat      540
atggatttta gtaaatatgg caaaaggcgt aattctccta atgagtatgt attttcggtt      600
agccgtgcag atttagaaaa ggaaattgtg actctatttg aagcgcaaag aaaatttcat      660
tcatcatatg catcggttga tttacaaaaa acatatttac gaatttgggc acaccaactc      720
ccttttgctt ctgggaatgc aattgtaaat aaagtaggat attgttcatt attaaaaggt      780
aaagaaaaga gagttccgaa agcaacatat acttttcaat atttcaatac actagatcaa      840
ataaaccgaa cacgattagg gcctgatttc caaccattta cgaaggaaca gagagacatt      900
attttagata aaatgtttca acggacagat tattataaaa aaaagacaat acccgaagtt      960
acttactatg atattcggaa atggttagca ctagatgaaa caattcaatt taaaggactt     1020
acctatgacc caaacgaaga gctgaaaaaa atagaattga aaccctttat taatttaaag     1080
ccattttatg aaattaaaaa ggtagttact aattacgccc aaaaaacaaa tgaggtattc     1140
tcaacattag actatgatac agttgcatat gctttaacag tttataaaac ggacaaagat     1200
attagatctt atttgaagag atctaataat ttatcaaaac gttgctatga tgatcaatta     1260
atagaagagc tattaactct ctcctataca aagtttggtc atttatcatt taaagcaatt     1320
aatcatgtac tgccaattat gcaagaggga aggacttatc aggaagcaat aaaccaatta     1380
ggatatgata ccactaatct taaaaaagaa aacagaagta tgttcttgcc tcttattcca     1440
gatgagataa caaatccaat tgttaaaaga gcgctaactc aagcacgtaa agttgtaaat     1500
gctattatta gaagatatgg ttctccaaat tctgttcata ttgaactagc tcgtgagctt     1560
tctaaaagtc atgacgagag aaagaaaata atgacagctc atgatgaaaa ttataagaaa     1620
aataaaggag ctatatcaat tttgatcgag aatggaattt taaatccgac aggatatgat     1680
attgtgcgtt ataagttatg gaaagagcaa ggagaacgat gtgcttattc gttaaaaaag     1740
attcctgcta atacgttttt taatgaattg aaaaaagagc gaagtggccc tccggttcta     1800
gaggtagatc acattttacc gtatagtcag agttttattg atagttacca taataaagta     1860
ttagtttatg gggatgagaa tcaaaaaaag ggaaatcgaa ttccatatac ttttttttca     1920
gaagaaaata aggagtggga aagctttgaa agctacgtaa gatcgaatag ttttttttct     1980
aaaaagaagc gcggatattt attgaaaaaa gcttacttgc caagagagag taacctgatt     2040
aaggagcgtc atttaaatga tacccgatat gctagtagct atttgaaaaa tttcattgag     2100
aaaaatttaa aatttaaaga agctgaaggt attacacgaa aaaaacatgt acagacggtt     2160
aacggtgtaa ttacagccca tctgcgaaaa agatggggct tagaaaaaga taggcaggaa     2220
acatatttgc atcatgcaat ggacgctatt attgttgctt gtacagatca tcatatggtc     2280
actaaagtaa cggagtacta tcaaataaaa gaaagtaata agtcaataaa gaaaccgtat     2340
tttcctttgc catggatggg ctttagagag gaaattttat cacatttaga aagtcagcca     2400
attgctagaa aaattagtga ggaacttaaa attggatatc aatcatctga ttatatactt     2460
gtatcgcgaa tgccaaaaag atctgtcact ggatcagctc atgaccagac agtcatgaaa     2520
aaaggcggta tcgataaaaa aggaaagact attatcataa agcgtgtgca cttaaaggat     2580
attaagtttg atgagaatgg cgattttaaa atggttggaa aagaacaaga tttagcaact     2640
tacgaagcga taaagcaaag atatttagag tatggaaaag aatcgaaaaa agcatttgaa     2700
acacctttat acaagcctag taaaaaagga aaaggaaacc tcattaaaaa aattaaagta     2760
gaagtgcaaa ccaaatcttt tgttcgagaa gttaatgggg gcgtagctca aaatggtgat     2820
ttagtaagaa tagatctgtt tgaaaaggat aataggtatt atatggtacc tatttacgta     2880
gtagatactg ttcgttccga actaccaaat aaagctgtaa aaagcagtaa aggctatgag     2940
caatggctaa caatagataa cagctttacg ttcaaattca gtttatattc ttatgattta     3000
gtacgacttg taaaaggtga tgaagatcgt ttcctatact ttagtactct tgatattaat     3060
tcggaccgtc ttaattttaa agatgtaaat aagccatcaa agcaggctga atatcgttat     3120
agtcttaaaa caattgagaa tttagaaaaa tatgaggttg gtgttttagg tgatttaagg     3180
ttagtgagac aagaaacacg taaaattttt taa                                  3213

<210>  27
<211>  3246
<212>  DNA
<213>  Bacillus cereus

<400>  27
ttgaaatacg tattaggatt ggatattgga atcgcatctt gtggttgggc tgtaataaat       60
caagaaaaac atagaattga agatttaggg gtacgtattt ttgataaagc tgagcaccct      120
aaagatggaa aatccttagc agcaccaaga cgtgaatctc gctctactag gaaaacactt      180
cgtcgtaaaa aacatagaat gcaacgtatc aaagtacttt tagttaagta tggtttatta      240
tctacgactg agattgaaaa tttatatgaa agtgctagtg aaattgatgt ttggaaccta      300
cgtttagatg ctctagaacg caagttaaat caaaaggaat ttgcaagagt ccttattcac      360
cttgctaaaa gaagaggatt taaatctaac atgaaagaaa caattctctc agaaaacgga      420
caaatcttag aaagtatttc agaaaatcaa aagattatgg agcaacaaaa ttatagaact      480
gttggagaaa tgattgtaaa agataacaag tttgaaaacc ataaaagaaa caaagatggt      540
acttatatcg ggactgttac tcgtcaacaa cttcaagatg aaatacatat gattttcaat      600
gcacaacgtt tgtttataaa tgaccttgca acagaggaat ttgaaagtag ctacttagaa      660
atttgggcat ctcaacgtcc ctatgcttct aaagatcaaa ttgaaaaaat gattggttac      720
tgtaccttag aaccaaaaga aaaaagagtc cctaaagctt catggtcatt tcaatatttt      780
gtagcgctac aaaccataaa caacctacga ctgattagta aagacaggat agaagaactc      840
tcttttgaag aaaagaaaca aattatgaat ctagcacttg aaaaacctat tgttaaatac      900
attgatatcc gaaaattatt atccatttct aatgaacttc attttaacaa tctattatat      960
tcagctgata cagtagatac aacggtggaa aataaaaaat gtatagaact caaagaatat     1020
cactctatta ataaggtata taaacaaatt tatggaaaga acgccttaaa tttattacct     1080
atagattacg atacaattgc atacggacta actatcttca aagacgataa agatatccta     1140
gaatacttac aaaataaata tataaataca aaaggaaaaa ctataagtaa tttaacaaaa     1200
aagacatacg atgacacgtt tattcaagca ttattgactt tgaacttcac aaaaatggga     1260
catttatcat ttaaagcctt aaaaaatatc attccttttt tagaagaggg aatgtcatat     1320
gataaagctt gtgataaggc aggatataac tttaagggaa catcatttac aaaaaaaaca     1380
aagtacttgc ctgttattcc acagaataca aatcctgttg tacatcgtgc tctttcacaa     1440
acaagaaagg tcataaatgc aattataaat aaatacggtt ctccagtttc aattcatatt     1500
gaaaccgcaa gagagttatc taaaacattc caggaaagaa aagaaataga tagcatgtac     1560
caggataact ccaaaaagaa tgaacacgcc attaataagc taaaagaatt aggtaacatt     1620
aatccctcgg gaataaatat tgtcaaattt aagctttgga aggaacaaga cggtagatgt     1680
atgtattccg gagaatatat tgaaccacat cgattatttg aagagggata taccgaagta     1740
gatcacatac taccctatag tcgtagttta gatgacagct ataacaataa aacattagct     1800
ttaggaatag aaaatcaacg aaaagggaac aaaactcctt atgagtacat ggggaacacc     1860
tcaatttggt acaaatttga aacgagggta cagtcgaata aaaaaattaa caaaaagaaa     1920
caacaaaaat tgcttctaca atacttttcg catgcaagag agcaagaatt tatagagcga     1980
aatctaaatg atacccgtta cgccacaata tatatatcag cgtttattca acaacacctc     2040
attttctctg aaagcttcag taaaaaaaga gttcatacag ttagcggaat tataacatct     2100
catgtacgta gtagatgggg atttaacaag gatcgtaaag aaagtcatat ccatcacgca     2160
ttagatgcag tgattgttgc tgtcacatct gatcaaatga ttcaaagagt aacaaattac     2220
tataaactaa aagaattaaa tagaaagctt caagccaaag ggatactgtt tcccgaacct     2280
tgggaggggt ttcgtttaga attagaagca agaatttctc caaataccca gcaatattta     2340
aagggaattt gttctaaaaa ttacgccgat atcaatctat ccgaaatcaa gcctatcttt     2400
gtttcaagaa tgcctaagcg atctattact ggtgaattac atcaagagac aattcgaaaa     2460
tttattggtt ataacgaaaa agggaaagta ttaaccgcaa taaaaacaaa gttagaagat     2520
attccttttg atgccaatgg tgattttcct atgtatggaa aagaaactga tttgtatacg     2580
tataatgcca tcaaagaacg ttatttaagt cataaaaaag ataaacgtaa atcatttcaa     2640
gaatccttat acaaacccac aaaaacagga gaaattgggc cacttataaa atccattaaa     2700
ataattgata caagaaccat tgtcaatcct gttaaccaag gtaaaggtgt cgtatataat     2760
agtaaaattg ctcgtactga tgtattcaaa aaagatgata agtactattt aattcccatt     2820
tatacaattg accttatgaa aaatgtttta cctcaaaaag caattacagc aggaaaagga     2880
tatgaagatt ggataaccat tgatcatagc tttacttttt tatttagcct ttttcctaat     2940
gacctaataa aaattgtccc ctcaaaaaat aaagaaatta aagctaggtc aacttcatca     3000
aaaaaagaaa tattactacc atcactcaca ggatatttta agaaggttca tagtggaaca     3060
gcaggcatta ctgttgaatc ccacgatggt aggtttatag cagatatagg ctcaaagcaa     3120
ttattattat ttgaaaaaca ccaggtagat gtactgggac attacacaaa aataaaggag     3180
gaaaaacgta ttgggatgtc gacatgtaat gataacaaaa agagctcagc tttcggttcg     3240
ctataa                                                                3246

<210>  28
<211>  4137
<212>  DNA
<213>  Lactobacillus fermentum

<400>  28
gtgaaagagt atcacattgg cttggacatt gggacaagct caattggctg ggcggtaacg       60
gatagccaat ttaaactgat gcgtatcaag gggaagacgg caatcggggt gcggttgttt      120
gaagaaggga agacggctgc agaacgtcga accttccgga caacgcggcg gcggttgaag      180
cggcgaaaat ggcgcttgca ctacttagat aaaatttttg ccccgcactt acaagaagtg      240
gatgaaaatt tcttacgccg tctgaagcaa tcaaatatcc acccggaaga tccagcgaag      300
aatcaagcct tcattggtaa gctcttattt ccggatctac tgaagaagaa tgaacgtggt      360
tacccaacac tgattaagat gcgcgatgaa ttgccagttg agcaacgcgc ccactaccca      420
gtaacgaaca tctacaagtt acgggaggcc atgattaacg aagatcgcca attcgatctg      480
cgggaagttt acctggccgt tcaccacatc gtgaagtacc ggggtcactt cttaaataac      540
gctagcgttg ataagttcaa agtggggaga atcgattttg acaaatcctt taacgttttg      600
aacgaagcct acgaggagct tcaaaacggc gaaggttcat tcacgattga gcctagcaag      660
gttgaaaaaa ttggacaact gttgctagat acgaagatgc gtaagttgga ccgccaaaaa      720
gcggttgcca aattgttaga ggtgaaggtc gctgacaaag aggagaccaa gcgcaacaag      780
caaattgcaa cggcgatgag taagttagtt cttggctaca aggcggactt tgcaacggta      840
gcgatggcga atggcaacga atggaagatc gatttaagtt ctgaaaccag tgaggacgag      900
attgaaaaat tccgggaaga attgagtgat gctcaaaatg atatcttaac ggaaatcact      960
agcctgttct cgcagatcat gctgaatgaa atcgtgccaa atgggatgtc gatttctgaa     1020
tcgatgatgg atcgttattg gatgcacgaa cgtcaattag cggaagttaa ggaatacttg     1080
gcgacccaac cagctagcgc gcggaaagat tttgaccaag tgtataacaa atacattggg     1140
caagcgccaa aggaaaaggg ctttgacctt gaaaagggac tcaagaagat tttatccaaa     1200
aaggaaaatt ggaaagaaat cgatgagtta ctcaaggcag gtgatttctt accaaagcaa     1260
cggacatcag ccaatggggt catcccacac cagatgcacc aacaagaatt ggaccgaatt     1320
attgaaaagc aagctaagta ctacccgtgg ctagcaacgg aaaacccagc cactggtgaa     1380
cgtgatcgtc accaagcgaa gtatgaactt gatcagctag tttccttccg gattccttac     1440
tatgttggac cgctagtaac gcctgaggtt caaaaggcga catctggcgc taagtttgct     1500
tgggcaaagc ggaaagaaga tggggagatt accccttgga acctgtggga taagattgac     1560
cgtgctgaat cagctgaagc ctttatcaag cggatgacgg ttaaggatac gtatctatta     1620
aacgaggatg tcctgcctgc taacagcttg ctataccaaa agtacaacgt cttaaacgaa     1680
ctaaacaacg ttcgagtgaa tggacgccgc ctatcagtcg gaattaaaca agatatttac     1740
actgagctct tcaagaagaa aaagacggtg aaggcaggtg acgtggccag cctagtgatg     1800
gcgaagacac gaggagttaa caagccaagt gttgaaggtt tatccgatcc gaagaagttc     1860
aattcaaatt tggcaaccta ccttgatcta aagtcaattg tgggtgacaa ggttgatgat     1920
aaccgttatc aaatggatct cgaaaacatt atcgagtggc gttccgtctt tgaagatggg     1980
gaaatttttg cggacaagtt aactgaagtg gaatggctga cggatgagca acgttctgcc     2040
cttgttaaga aacggtataa gggctgggga cgtttatcca agaagctact gacgggaatc     2100
gttgacgaga acggccaacg gatcattgat ctgatgtgga atactgatca aaacttcatg     2160
cagattgtca accagcctgt ctttaaagaa cagattgacc aactgaacca aaaggccatc     2220
accaatgatg ggatgacttt gcgggagcgg gtcgagagcg ttctggatga cgcctatact     2280
tcaccgcaga acaagaaggc catctggcaa gttgttcggg tggtggaaga tattgttaaa     2340
gcggtcggga atgcaccaaa gtcgatttca attgaatttg cccgtaatga aggcaacaag     2400
ggagaaataa cccggagccg gcgtactcaa ttgcagaaat tatttgaaga tcaggcccat     2460
gaattagtta aggatacgag cttgactgag gaattggaga aggcaccgga tctttccgat     2520
cgttattact tctacttcac ccaaggtggt aaggatatgt acaccggtga tccaatcaac     2580
ttcgatgaaa tttctaccaa gtatgatatt gaccacattt tgccacaatc cttcgtgaag     2640
gatgattcct tagataatcg ggtgttagta agtcgggcgg agaataataa gaagtctgac     2700
cgggtgccag ctaagcttta cgcagccaag atgaaaccat actggaacca acttttgaag     2760
cagggattga tcacgcaacg gaagtttgaa aacctgacga tggacgttga tcaaaatatt     2820
aagtatcggt cacttggatt cgtgaagcgc caattagttg aaacacgcca agttatcaag     2880
ttgacggcta acatcttggg tagtatgtac caagaagccg ggacggacat cattgagact     2940
cgggctggtt taactaagca attacgcgag gaattcgatt taccaaaggt tcgtgaagta     3000
aacgactatc accacgcagt tgatgcttac ctgacaacgt ttgctgggca atatttgaac     3060
cgccgttatc cgaaattacg ctccttcttc gtatacggtg agtacatgaa gttcaagcat     3120
gggtcagatc tgaagctacg taactttaac ttcttccatg aattgatgga aggcgacaag     3180
agccaaggta aggttgtcga tcaacaaact ggtgagctga ttacgacaag ggatgaagta     3240
gccaagagct ttgatcgatt attgaacatg aagtatatgc tggtatcgaa ggaagttcac     3300
gaccggagtg accaactgta tggagcaacg attgtaacag caaaggaatc tggtaagctc     3360
acttcaccaa ttgagatcaa gaaaaatcga cctgttgatt tgtatggtgc ttatacgaat     3420
ggaacgtcag ctttcatgac gatcattaag tttactggaa acaaacctaa gtataaggtg     3480
attggggttc caacaacatc ggcggtcggt ttaaaacgag ttgggaaacc aggcagtgaa     3540
tcatataacc aagaattaca tcgaatcatt aaatctaatc cgaaggtaaa gaaagatttt     3600
gagattgtag ttccacatgt ttcgtatagt cagttgatag ttgatggtga ctgcaaattt     3660
accctagcta gtgatactta tcagcatccg gcaactcagc tagttctttc taaagaatcg     3720
atggaaataa ttgcagatga ttttaaattt gtgaaagaaa atccggcaac tgcggatgaa     3780
caacttgtta gggtttttga tgaaattgtt aatcaaatga accattactt tactatcttt     3840
gaccaacgta gtaatcgtca aaaggtaacg aaggctcgag ataagtttgt atcgttacca     3900
acggaatcag agtatgaggg tgctaagaaa acgcaagtag ggaagacaga agtcattacg     3960
aacttactga tgggtctaca tgccaatgct gcacaaggtg atttgaaagt attaggatta     4020
tcaacctttg ggtttttcca gagttcaggt ggactgaatt taagtgaaga tgcaatgatc     4080
gtataccagt caccaaccgg tttgtttgaa cgtcgcattt gtttgaaaga catttaa        4137

<210>  29
<211>  4014
<212>  DNA
<213>  Enterococcus faecalis

<400>  29
atgaagaaag actacgttat cggtttggat atagggacta attctgtcgg ttgggcagtt       60
atgacagaag actatcagtt ggtgaagaaa aaaatgccta tttatggaaa cactgaaaaa      120
aagaaaatca agaaaaattt ttggggtgtg cgtttatttg aagaagggca tacagccgaa      180
gatcgccgat taaaaagaac agcacgacga agaattagtc gtcgacggaa tcgtttacgc      240
tacttacaag ctttttttga agaagcgatg acagctttgg atgaaaactt ttttgctcgt      300
ttacaagaga gttttttagt gcctgaagat aagaagtggc acagacatcc gatttttgct      360
aagttggaag atgaagtagc ttaccatgaa acgtatccga caatctacca tttacgcaaa      420
aaattagcag attcatctga gcaagcagat ttacgactaa tttatttggc gttggcatat      480
attgtcaaat atcgtggaca ttttttaatt gaagggaaat taagtacaga aaatatttct      540
gttaaagaaa aatttcaaca atttatgatc atttataacc agacctttgt gaatggagag      600
ggtcgcttag ttagtgcgcc attacctgaa tctgtcttga ttgaggaaga gttgactgaa      660
aaagcttctc ggactaaaaa atctgaaaaa gtcttacaac aatttcctca agaaaaagct      720
aatggcttat ttggtcagtt cttaaagcta atggtaggga ataaggctga ctttaaaaaa      780
gtttttggtt tggaagaaga agccaaaata acctacgcta gtgaaagcta tgaagaagat      840
ttagaaggca ttttagcaaa ggttggggat gaatatagtg acgtgttttt agctgctaaa      900
aatgtgtacg atgcagttga attatcaacg attttagcag attcggataa aaaaagttac      960
gcgaaattat cttctagcat gattgtccgt tttacagaac atcaagaaga tttaaaaaaa     1020
ttcaaacgat ttattcgtga aaattgtcca gacgaatatg ataatctctt taaaaatgaa     1080
cagaaagacg gctatgcagg ctacattgca cacgcaggta aggtttcaca gcttaaattt     1140
taccagtatg ttaagaaaat cattcaagat attgctggag cagaatattt tttagaaaaa     1200
attgctcaag aaaacttttt aagaaagcaa cggacctttg ataatggggt gattcctcat     1260
caaattcatt tggctgagtt acaagcaatc attcatcgtc aagcggccta ttatccattt     1320
ttaaaagaaa atcaagaaaa aattgaacaa ctggttacat ttcgaattcc ttattatgtc     1380
ggaccattat caaaaggaga tgcaagtacc ttcgcttggc taaaacgtca aagtgaggaa     1440
ccaattcgac cttggaacct tcaagaaacc gttgatttgg accaatcagc gacagccttt     1500
attgaacgaa tgaccaattt tgatacgtat ttaccttctg aaaaagtttt accgaaacat     1560
agtttgttat atgaaaagtt tatggtattt aatgaattga ccaagatttc ttatacggat     1620
gatcgaggca tcaaagccaa tttttcaggt aaggaaaaag aaaaaatctt tgattatctg     1680
tttaagacgc gtcgcaaagt taagaaaaag gatatcattc aattctatcg aaacgaatat     1740
aatacggaga ttgtcacgct tagtggactt gaagaagacc aatttaatgc tagttttagc     1800
acgtatcagg atttactgaa atgtggtttg acacgagcag aattagacca cccagataat     1860
gccgaaaaat tggaagatat cataaaaatt ttaactattt ttgaagatcg gcaacgaatt     1920
cggacgcaac tttctacatt caaagggcag ttctcagcag aagtactaaa aaaattagaa     1980
cgcaagcact acactggctg gggaagattg tcgaagaaat taatcaatgg tatctacgat     2040
aaagaatcgg gtaaaacaat tttggactat ttagttaaag atgatggggt ctcaaaacac     2100
tataatcgca attttatgca actgattaat gattcacaat tatcttttaa aaatgctatt     2160
caaaaagcac agtccagtga acatgaagaa acattaagtg aaactgtcaa tgaattagct     2220
ggtagcccag caataaaaaa aggaatttat caaagtttaa aaattgtcga tgaactagtc     2280
gcgattatgg gttatgcgcc taagcggatt gttgtcgaaa tggcacgtga aaatcaaacg     2340
actagcactg gcaagagaag atccatccaa cgcttgaaaa tagttgaaaa agcaatggcc     2400
gaaatcggca gcaatttatt aaaagaacaa ccaacgacta atgaacagtt acgagatacc     2460
cgtcttttcc tttactatat gcaaaatggt aaagatatgt acacgggaga tgaattatcg     2520
cttcatcgtt tatctcacta tgatattgat catattatcc cacaaagttt tatgaaagac     2580
gattcattgg ataacctagt tttagtgggc tctactgaaa atcgagggaa atccgatgat     2640
gtacctagca aggaagttgt taaggatatg aaagcttatt gggagaaatt atatgctgct     2700
ggcttaatta gtcaacggaa attccaacgt ctgaccaaag gggagcaagg tggcttgact     2760
ctcgaagaca aagcgcattt tatccaacga caattagtag aaactcgtca aattaccaaa     2820
aatgttgcag ggatcttaga tcaacgctac aatgccaagt caaaagagaa aaaagtccaa     2880
atcatcacct tgaaagctag tttaacgagc caatttcgtt cgatttttgg cttgtataaa     2940
gttcgtgaag tgaatgatta tcaccatgga caagatgctt atttaaactg tgtggtcgca     3000
accacgttat taaaagttta tcctaattta gcaccagaat ttgtttacgg agaatatcct     3060
aagttccaga cctttaaaga aaataaagcc acggcgaagg ctataattta tacaaatttg     3120
ctgcgctttt tcacggaaga tgaaccacgg ttcacgaagg atggcgaaat tctttggagt     3180
aacagttatt taaaaactat caaaaaagaa ttaaattacc atcaaatgaa tattgtcaaa     3240
aaagtagaag tgcaaaaagg cggtttttca aaagagtcga ttaaacccaa aggaccatcg     3300
aataaattga ttcctgtcaa aaatggtttg gatccccaaa aatatggcgg ttttgatagt     3360
cctatagttg catatacagt gctattcacg catgaaaaag gtaaaaaacc tcttattaaa     3420
caggagatac tgggcattac gattatggaa aaaacaaggt ttgaacaaaa tcctattctt     3480
tttttagagg agaaaggctt cctacggcct cgtgtattaa tgaaattgcc taagtataca     3540
ctgtatgaat ttccagaggg acgccggcgc ttattagcca gcgctaaaga agcgcaaaaa     3600
gggaaccaga tggttttacc tgaacattta cttacattac tgtaccatgc gaaacaatgt     3660
ttgttaccaa atcaatcaga aagtttggct tatgtagaac aacatcaacc agaatttcaa     3720
gagattttag agagagtggt tgactttgct gaagtgcata cattagccaa gtcaaaagtc     3780
cagcaaattg tgaaactttt tgaagcaaat caaacagcag atgtgaaaga gattgcggca     3840
tcctttatcc aacttatgca gtttaatgcg atgggcgcac caagtacgtt taaatttttc     3900
caaaaagaca ttgagcgagc acgctacacg tcaatcaaag aaatttttga tgccactatc     3960
atttaccaat cgactacggg actgtatgaa acacgcagaa aggttgtcga ctag           4014

<210>  30
<211>  4014
<212>  DNA
<213>  Bacillus cereus

<400>  30
atgaagaaag attacgttat tggtctggat ataggaacta attctgtcgg ctgggcagtt       60
atgacagaag actatcagtt ggtgaagaaa aaaatgccta tttatggaaa cactgaaaaa      120
aagaaaatta agaaaaattt ttggggtgtg cgtttatttg aagaagggca tacagccgaa      180
gatcgccgat taaaaagaac agcacgacga agaattagtc gtcgacggaa tcgtttacgc      240
tacttacaag ctttttttga agaagcgatg acagatttgg atgaaaactt ttttgctcgt      300
ttacatgaga gttttttagt gcctgaagat aagaagtggc acagacatcc gatttttgct      360
aagttggaag atgaagtagc ttaccatgaa acgtatccga caatctacca tttacgcaaa      420
aaattagcag attcatctga gcaagcagat ttacgactaa tttatttggc gttggcccat      480
attgtcaaat atcgtggaca ttttttaatt gaaggaaaac taagtacaga aaatacttct      540
gttaaagaac aatttcaaca atttatggtc atttataacc aaacctttgt gaatggggag      600
agtcgcttag ttagtgcgcc tttacctgaa tctgtcttga ttgaggaaga gttaactgaa      660
aaagcttctc ggactaaaaa atctgaaaaa gtcttacaac aatttcctca agaaaaagct      720
aatggcttat ttggtcagtt tttaaagcta atggtaggga ataaagctga ctttaaaaaa      780
gtttttgctt tggaagaaga agccaaaata acctacgcta gtgaaagtta tgaagaagat      840
ttagaaggca ttttagcaaa gattggggat gaatatagtg acgtgttttt agctgctaaa      900
aatgtgtacg atgcagttga attatcaacg attttagcag attcggataa aaaaagtcac      960
gcgaaattat cttctagcat gattgtccgt tttacagaac atcaagaaga tttaaaaaaa     1020
ttcaaacggt ttattcgtga aaattgtcca gacgaatatg ataatctctt taaaaatgaa     1080
cagaaagacg gctatgcagg ttacattgca cacgcaggta aggtttcaca gcttaaattt     1140
taccagtatg ttaagaaaat cattcaagat attgctggag cagaatattt tttagaaaaa     1200
attgctcaag aaaacttttt aagaaagcaa cggacctttg ataatggggt gattcctcat     1260
caaattcatt tggctgagtt acaagcaatc attcatcgtc aagcggccta ttatccattt     1320
ttaaaagaaa atcaagaaaa aattgaacaa ctggttacat ttcgaattcc ttattatgtc     1380
ggaccattat caaaaggaga tgcaagtacc ttcgcttggt taaaacgtca aaatgagaaa     1440
ccaattcgac cttggaacct tcaagaaacc gttgatttgg accaatcagc gacagccttt     1500
attgaacgaa tgaccaattt tgatacgtat ttaccttctg aaaaagtttt accgaaacat     1560
agtttgttat atgaaaagtt tatggtattt aatgaattga ccaagatttc ttatacggat     1620
gatcgaggaa tcaaagccaa tttttcaggt aaggaaaaag aaaaaatctt tgattatctg     1680
tttaagacgc gtcgaaaagt taagaaaaag gatataattc aattctatcg aaacgaatat     1740
aatacggaga ttgtcacgct tagtggactt gaagaagacc aatttaatgc tagttttagc     1800
acgtatcagg atttactgaa atgtggtttg acaagagcag aattagacca cccagataat     1860
gccgaaaaat tggaagatat cataaaaatt ttaactattt ttgaagatcg gcaacgaatt     1920
cggacgcaac tttccacatt caaagggcag ttctcagcag aagtactaaa aaaattagaa     1980
cgcaagcact acactggctg gggaagattg tcgaagaaat taatcaatgg tatctacgat     2040
aaagaatcgg gtaaaacaat tttggactat ttagttaaag atgatggggt ctcaaaacac     2100
tataatcgca attttatgca actgattaat gattcacaat tatcttttaa aaatgcgatt     2160
caaaaagcac agtccagtga acatgaagaa acattaagtg aaactgtcaa tgaattagct     2220
ggtagcccag caataaaaaa aggaatttat caaagtttaa aaattgtcga tgaactagtc     2280
gcgattatgg gttatgcgcc taagcggatt gttgtcgaaa tggcacgtga aaatcaaacg     2340
actagcactg gcaagagaag atccatccaa cgcttgaaaa tagttgaaaa agcaatggcc     2400
gaaatcggca gcaatttatt aaaagaacaa ccaacgacta atgaacagtt acgagatacc     2460
cgtcttttcc tttactatat gcaaaatggt aaagatatgt acacgggaga tgaattatcg     2520
cttcatcgtt tatctcacta tgatattgat catattatcc cacaaagttt tatgaaagac     2580
gattcattgg ataacctagt tttagtgggc tctactgaaa atcgagggaa atccgatgat     2640
gtacctagca aggaagttgt taaggatatg aaagcttatt gggagaaatt atatgctgct     2700
ggcttaatta gtcaacggaa attccaacgt ctgaccaagg gggagcaagg tggcttgact     2760
ctcgaagaca aagcgcattt tatccaacgg caattagtag aaactcgtca aattaccaaa     2820
aatgttgcag ggatcttaga tcaacgctac aatgccaagt caaaagagaa aaaagtccaa     2880
atcatcacct tgaaagctag tttaacgagc caatttcgtt cgatttttgg cttgtataaa     2940
gtccgtgaag tgaatgatta tcaccatgga caagatgctt atttaaactg tgtggtcgca     3000
accacgttat taaaagtttg tcctaattta gcaccagaat ttgtttacgg agaatatcct     3060
aagttccaga cctttaaaga aaataaagcc acggcgaagg ctataattta tacaaatttg     3120
ctgcgctttt tcacggaaga tgaaccacgg ttcacgaagg atggcgaaat tctttggagt     3180
aacagttatt taaaaactat caaaaaagaa ttaaattacc atcaaatgaa tattgtcaaa     3240
aaagtagaag tgcaaaaagg cggtttttca aaagagtcga ttaaacccaa aggaccatcg     3300
aataaattga ttcctgtcaa aaatggtttg gatccccaaa aatatggcgg ttttgatagt     3360
cctgtagttg cttatacagt gctattcacg catgaaaaag gtaaaaaacc tcttattaaa     3420
caggagatac tgggcattac gattatggaa aaaacaaggt ttgaacaaaa tcctattctt     3480
tttttagagg agaaaggctt cctgcggcct cgtgtattaa tgaaattgcc taagtataca     3540
ctgtatgaat ttccagaggg gcgccggcgc ttattagcta gtgctaaaga agcgcaaaaa     3600
gggaaccaga tggttttacc cgaacattta cttacattac tgtaccatgc gaaacaatgt     3660
ttgttaccaa atcaatcaga aagtttggct tatgtagaac aacatcaacc agaatttcaa     3720
gagattttag agagagtggt tgactttgct gaagtgcata cattagccaa gtcaaaagtc     3780
cagcaaattg tgaaactttt tgaagcaaat caaacagcag atgtgaaaga gattgcggca     3840
tcctttatcc aacttatgca gtttaatgcg atgggcgcac caagtacgtt taaatttttc     3900
caaaaagata ttgagcgagc acgctacacg tcaatcaaag aaatttttga tgccactatc     3960
atttaccaat cgactacggg cctgtatgaa acacgcagaa aggttgtcga ctag           4014

<210>  31
<211>  4014
<212>  DNA
<213>  Enterococcus faecalis

<400>  31
atgaagaaag actacgttat cggtttggat atagggacta attctgtcgg ttgggcagtt       60
atgacagaag actatcagtt ggtgaagaaa aaaatgccta tttatggaaa cactgaaaaa      120
aagaaaatca agaaaaattt ttggggtgtg cgtttatttg aagaagggca tacagctgaa      180
gatcgccgat taaaaagaac agcacgacga agaattagtc gtcgacggaa tcgtttacgc      240
tacttacaag ctttttttga agaagcgatg acagatttgg atgaaaactt ttttgctcgt      300
ttacaagaga gttttttagt gcctgaagat aagaagtggc acagacatcc gatttttgct      360
aagttggaag atgaagtagc ttaccatgaa acgtatccga caatctacca tttacgcaaa      420
aaattagcag attcatctga gcaagcagat ttacgactaa tttatttggc gttggcccat      480
attgtcaaat atcgtggaca ttttttaatt gaaggaaaac taagtacaga aaatacttct      540
gttaaagaac aatttcaaca atttatggtc atttataacc aaacctttgt gaatggagag      600
agtcgcttag ttagtgcgcc attacctgaa tctgtcttga ttgaggaaga gttaactgaa      660
aaagcttctc ggactaaaaa atctgaaaaa gtcttacaac aatttcctca agaaaaagct      720
aatggcttat ttggtcagtt cttaaagcta atggtaggga ataaagctga ctttaaaaaa      780
gtttttggtt tggaagaaga agccaaaata acctacgcta gtgaaagcta tgaagaagat      840
ttagaaggca ttttagcaaa ggttggggat gagtatagtg acgtgttttt agctgctaaa      900
aatgtgtacg atgcagttga attatcaacg attttagcag attcggataa aaaaagtcac      960
gcgaaattat cttctagcat gattgtccgt tttacagaac accaagaaga tttaaaaaaa     1020
ttcaaacgat ttattcgtga aaattgtcca gacgaatatg ataatctctt taaaaatgaa     1080
cagaaagacg gttatgcagg ctacattgcg cacgcaggta aggtttcaca gcttaaattt     1140
taccagtatg ttaagaaaat cattcaagat attgctggag cagaatattt tttagaaaaa     1200
attgctcaag aaaacttttt aagaaagcaa cggacctttg ataatggggt gattcctcat     1260
caaattcatt tggctgagtt acaagcaatc attcatcgtc aagcggccta ttatccattt     1320
ttaaaagaaa atcaagaaaa aattgaacaa ctggttacat ttcgaattcc ttattatgtc     1380
ggaccattat caaaaggaga tgcaagtacc ttcgcttggt taaaacgtca aagtgaggaa     1440
ccaattcgac cttggaacct tcaagaaacc gttgatttgg accaatcagc gacagccttt     1500
attgaacgaa tgaccaattt tgatacgtat ttaccttctg aaaaagtttt accgaaacat     1560
agtttgttat atgaaaagtt tatggtattt aatgaattga ccaagatttc ttatacggat     1620
gatcgaggaa tcaaagccaa tttttcaggt aaggaaaaag aaaaaatctt tgattatctg     1680
tttaagacgc gtcgaaaagt taagaaaaag gatataattc aattctatcg aaacgaatat     1740
aatacggaga ttgtcacgct tagtggactt gaagaagacc aatttaatgc tagttttagc     1800
acgtatcagg atttactgaa atgtggtttg acaagagcag aattagacca cccagataat     1860
gccgaaaaat tggaagatat cataaaaatt ttaactattt ttgaagatcg gcaacgaatt     1920
cggacgcaac tttccacatt caaagggcag ttctcagcag aagtactaaa aaaattagaa     1980
cgcaagcact acactggctg gggaagattg tcgaagaaat taatcaatgg tatctacgat     2040
aaagaatcgg gtaaaacaat tttggactat ttagttaaag atgatggggt ctcaaaacac     2100
tataatcgca attttatgca actgattaat gattcacaat tatcttttaa aaatgctatt     2160
caaaaagcac agtccagtga acatgaagaa acattaagtg aaactgtcaa tgaattagct     2220
ggtagcccag caataaaaaa aggaatttat caaagtttaa aaattgtcga tgaactagtc     2280
gcgattatgg gttatgcgcc taagcggatt gttgtcgaaa tggcacgtga aaatcaaacg     2340
actagcactg gcaaaagaag atccatccaa cgcttgaaaa tagttgaaaa agcaatggcc     2400
gaaatcggca gcaatttatt aaaagaacaa ccaacgacca atgaacagtt acgagatacc     2460
cgtcttttcc tttactatat gcaaaatggt aaagatatgt acacgggaga tgaattatcg     2520
cttcatcgtt tatctcacta tgatattgat catattatcc cacaaagttt tatgaaagac     2580
gattcattgg ataacctagt tttagtgggc tctactgaaa atcgagggaa atctgatgac     2640
gtcccaagta agaaagttgt taagaagatg aaagcttatt gggagaaatt atatgctgct     2700
ggcttaatta gtcaacggaa attccaacgt ctgaccaagg gggagcaagg tggcttgact     2760
ctcgaagaca aagcgcattt tatccaacgg caattagtag aaactcgtca aattaccaaa     2820
aatgttgcag ggatcttaga tcaacgctac aatgccaagt caaaagagaa aaaagtccaa     2880
atcatcacct tgaaagctag tttaacgagc caatttcgtt cgatttttgg cttgtataaa     2940
gtccgtgaag tgaatgatta tcaccatgga caagatgctt atttaaactg tgtggtcgca     3000
accacgttat taaaagttta ccctaattta gcaccagaat ttgtttacgg agaatatcct     3060
aaattccagg cctttaaaga aaataaagcc acggcgaaga ctataattta tacaaatttg     3120
atgcgctttt tcacggaaga tgaaccacgg ttcacgaagg atagcgaaat tctttggagt     3180
aacagttatt tgaaaactat caaaaaagaa ttaaattacc atcaaatgaa tattgtcaaa     3240
aaagtagaag tgcaaaaagg cggtttttca aaagagtcga ttaaacccaa aggaccatcg     3300
aataaattga ttcctgtcaa aaatggtttg gatccccaaa aatatggcgg ttttgatagt     3360
cctgtagttg cttatacagt gctattcacg catgaaaaag gtaaaaaacc tcttattaaa     3420
caggagatac tgggcattac gattatggaa aaaacaaggt ttgaacaaaa tcctattctt     3480
tttttagagg agaaaggctt cctgcggcct cgtgtattaa tgaaattgcc taagtataca     3540
ctgtatgaat ttccagaggg gcgccggcgc ttattagcta gtgctaaaga agcgcaaaaa     3600
gggaaccaga tggttttacc tgaacattta cttacattac tgtaccatgc gaaacaatgt     3660
ttattaccaa atcaatcaga aagtttggct tatgtagaac aacatcaacc agaatttcaa     3720
gagattttag agagagtggt tgactttgct gaagtgcata cattagccaa gtcaaaagtc     3780
cagcaaattg tgaaactttt tgaagcaaat caaacagcag atgtgaaaga gattgcggca     3840
tcctttatcc aacttatgca gtttaatgcg atgggcgcac caagtacgtt taaatttttc     3900
caaaaagata ttgagcgagc acgctacacg tcaatcaaag aaatttttga tgccactatc     3960
atttaccaat cgactacggg cctgtatgaa acacgcagaa aggttgtcga ctag           4014

<210>  32
<211>  3993
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Cas endonuclease of Locus 14

<400>  32
atggaaaaag agtatacgat tggattagat attgggacaa attcggttgg atgggcagtg       60
ttgacggatg attatcgatt agtcgcaaga aaaatgagta ttcaaggaga ctcgaataga      120
aagaaaataa aaaagaattt ttggggtgca cgtttattcg aagaaggtaa aactgcacaa      180
tttcgacgga tcaaacgaac gaaccgtcgt aggatcgcac gaagacgtca aagagtttta      240
gcattacaag atatttttgc agaagagata cataaaaaag atcccaattt ttttgctcgg      300
ctagaagaag gagatcgtgt ggaagcagac aaacgatttg ctaagtttcc tgtttttgct      360
acattgtcgg aggaaaaaaa ttatcatcgt caatatccga ccatctacca tttgaggcat      420
gatctagcaa actcaaaaga acaagcagat attcgtttag tgtacttagc gattgcccat      480
tgcttgaagt acagagggca ctttttgttt gaaggagaat tagatactga aaatacctcg      540
gtaaccgaaa attatcagca atttttacaa gcataccaac agttctttcc agaacctata      600
ggagatttgg atgatgctgt ccctattttg acagagcggc tatctaaggc aaaacgagtg      660
gaaaaagtat tagcttatta tccatctgaa aaaagtactg gaaattttgc tcaattcctt      720
aaactaatgg tcggaaatca agcaaatttt aaaaagacgt ttgatttaga agaagaaatg      780
aagttgaatt ttactcgtga ttgttatgaa gaggatttaa atgaactgct agaaaaaaca      840
agtgacgatt atgcagaatt atttttaaaa gcgaagggtg tgtatgatgc gattttactt      900
tcgcaaatcc tttctaagtc agatgatgaa acgaaagcta agttgtctgc gaatatgaag      960
ttgcgctttg aagagcacca acgagacctt aaacaattaa aagaactagt ccgtagagac     1020
ttacctaaaa agtacgatga tttctttaag aatcgcagta agaatggata cgctgggtat     1080
gtcaagggga aagcgacaca agaagatttt tataaatttc taagaacaga actagctgga     1140
ttagaggaaa gccaatcaat catggaaaaa attgatctag agatctatct attgaaacaa     1200
cgtacctttg caaatggggt gattcctcat caaatccatt tagttgaaat gagagaaatt     1260
atggatcggc agaaacgttt ttatcctttt ctaaaagggg cacaaggaaa aatcgagaaa     1320
ctactgacgt ttcgaatccc atattacgta ggaccgttgg cacaagaagg tcaaagtcct     1380
ttcgcttgga tcaaacgtaa gagtccgagc caaatcactc catggaattt tgcagaagtg     1440
gttgataaag aaaattcagc cattgaattt attgagcgaa tgacaaatca agatacgtat     1500
ttaccaaagg aaaaagtttt accaaaacaa agtttgattt atcaaagatt catgatcttc     1560
aatgaattga caaaagtcag ttatacggat gaacgtggca aatctcacta tttttcaagt     1620
gaacaaaaac gcaagatttt taacgagttg ttcaagcaac atccaagagt aacagaaaaa     1680
caattgagga aatttttaga gttgaacgag cagatcgatt caactgaaat caaaggaatt     1740
gaaacgtcat tcaatgcttc ttatagcacc tatcatgatt tgttgaaatt atcagatcag     1800
atggatacat tattagatga tcccgatatg acaacgatgt ttgaagaaat tatcaaaatt     1860
ttgacgattt ttgaagacag agaaatgatt agggaacaac tgaaaccgta cgaaactgtc     1920
ttaggtcttc cagctatcaa gaaattagca aaaaaacatt atactggttg gggacggcta     1980
tcggaaaaaa tgatccaagg aatgcgagag aagcagtccc ggaaaaccat tcttgattat     2040
ttgatcgatg atgatgattt tccttgcaat cgtaatcgaa atttcatgca actaatcaat     2100
gatgatcatc tttcgtttaa agaaacgatt gctaatgaat tgatcatgag cgactcaaac     2160
gtattgcttg atcaagtgaa ggctatccca ggaagtcctg cggtcaaaaa agggatttgg     2220
caaagtatca aaatcgtcga agaaatcatt ggtatcatcg gtaaggcacc taagaacata     2280
gtgattgaaa tggcacgtga gaatcaaaga acaagccgtt caagaccccg cttaaaagcc     2340
ttagaagaag cattgaagaa tatcgacagt ccattgttga aagactatcc aacagataat     2400
caagcgctac aaaaagatcg actgtattta tattatttgc aaaatggaaa agatatgtat     2460
acaggtgaac cactagagat tcatcgttta tcagaatatg atattgacca tattattcct     2520
agaagtttta ttgttgataa ttctttagat aataaggtcc tagtttcatc aaaagtcaat     2580
cgtggaaagt tagataatgc cccggaccca cttgttgtca aaagaatgcg atcacattgg     2640
gaaaagctac atcaagcaaa attgatcagt gacaaaaaac tagccaatct tacaaaacaa     2700
aatctgaccg aggcagacaa ggcaagattt atccaacgcc agttagtcga aacaagacag     2760
ataacgaaac atgttgccaa tctgttacat cagcatttta atttaccaga agaagtaagt     2820
gcgactgaga aaacaagtat cattaccttg aaatcaacgt tgacaagcca attccgtcag     2880
atgttcgata tttataaggt gagagagatc aatcatcacc accatgccca cgacgcttat     2940
ttaaacggag tagtcgcaat gactttacta aaaaaatatc ctaagttggc accagaattt     3000
gtctacggaa gttatatcaa aggggatatc aaccagatca ataaagcaac tgcaaaaaaa     3060
gaattctatt ctaatatcat gaaatttttt gaaagtgaag aaatcatttg tgatgagcaa     3120
ggtgaagtga tttggaataa aaaacgtgat ctctcaacaa tcaagaagac gattggcgca     3180
caccaagtga atatcgttaa gaaagtagaa aaacaaaaag gtggattcta taaggaaaca     3240
attaattcaa aagcgaatcc agaaaaacta attccaagaa aagcatcatt agatcctttg     3300
aaatatggtg gctatggtag cccacttgtg gcatatacgg tgatttttat ctttgaaaaa     3360
ggaaaacaga agaaggtaac caaaggaatc gaaggaatta ccgttatgga acaattgaga     3420
ttcgaacaag acccacgaga gtttctaaaa acaaaaggct atgagggcgt aaaacaatgg     3480
ctgatattgc ctaaatatat attattcgaa gcacaaggtg gatatcggag aatgattgcg     3540
agtcatcaag aaacgcaaaa agctaactca ttgattttac ctgaaaatct agttacattg     3600
ctttatcatg caagacatta cgatgaaatc aatcataaag tgagttttga ttatgtcaat     3660
gcgcataaag aagggtttaa tgacattttt gattttatct ctgactttgg ggtgcgttat     3720
attttggctc ctcaacatct tgaaaaaata aaagttgcct atgaaaaaaa taaagaggta     3780
gatctgaaag aaatgataga tgctatttta tctttattga aatttacgtt atttggtgct     3840
tctgttgagt ttaagttttt tgatattaag atattaaaaa gatataagag tttgaccgac     3900
atttgggaag caaccattat ctaccaatcg gttactggat tatatgaaag gcgagtggag     3960
gtaaggaagt tatgggatgg agaacgcttg taa                                  3993

<210>  33
<211>  3453
<212>  DNA
<213>  Enterococcus faecalis

<400>  33
atgtacagta taggtttaga tttagggatt agtagtgttg gttggtcagt aattgatgaa       60
cggacaggca atgttattga tttaggtgtc cgtttattta gtgcgaaaaa tagtgaaaaa      120
aatttagaac gacgcacaaa tcgaggtgga cgtcgtttaa ttagacggaa aacgaatcgc      180
ttaaaagatg caaaaaaaat acttgcggct gttggatttt atgaagataa atcattaaaa      240
aatagttgcc cgtaccaatt aagagtaaaa ggattgacag aaccattaag caaaggagaa      300
atttataaag tgactcttca cattttaaaa aaacgtggaa ttagttactt agacgaagat      360
gatacggaag cagcgaaaga aagtcaagat tataaggaac aagttaggga aaatgctcag      420
ttgttaacaa aatatacgcc gggtcaaatc caattacagc ggctgaaaga aaataatcga      480
gtgaaaacag gaatcaatgc tcaaggtaat tatcagttaa atgtttttaa agtttctgct      540
tatgcaaatg aattggcaac cattcttaaa acccaacaag ccttttatcc taacgaattg      600
acagatgatt ggattgcatt atttgtacag cctggtattg cagaggaagc tggattaatt      660
tatcgcaaac gaccgtatta tcatggacca ggaaatgaag ccaataacag tccttatggt      720
cgttggtctg attttaaaaa aacaggccaa ccagcaacaa atatttttga taaattgatt      780
ggcaaagact ttcaaggtga actacgagca agcggcttaa gtctatctgc acaacaatat      840
aatttactca atgatttaac caatttaaaa attgatggag aaataccact ttcgctagaa      900
caaaaagaat acattttagc agaattaatg accaaagaat ttactcgttt tggcgttaat      960
gatgtggtta aattgctggg tgtaaaaaaa gaacgattaa gtggttggcg tttggataaa     1020
aaaggtaaac cagaaattca tacattaaaa gcctatcgca attggcggaa aatttttgct     1080
gaagcaggga tcgatttggc tacgttacca acagaaacga ttgactgttt agcgaaagtt     1140
ttaaccttaa ataccgaacg cgaagggatt gaaaatacat tagcttttga actgcctaag     1200
ttagcagaac cagtaaagtc actagtttta gatcattaca aagaattaag ccaaagcatt     1260
agcacgcaag cgtggcatcg tttttcttta aaaacattac acttattaat tccagaacta     1320
atgaacgcta cctcagaaca aaatacactc ttagaacagt ttcagttaaa gtcaggtgtt     1380
agaacacggt atagtgaata taataaatta ccaacaaaag atgtcttggc agaaatttat     1440
aatccaacgg tgaacaaaac agtgagtcaa gccttcaaag ttatggatgc tttgttggaa     1500
aaatatggca aagagcaaat tcgttacatc actattgaaa tgcctaggga cgataacgaa     1560
gaagatgaaa aaaaacgaat aaaagaatta catgcaaaga atagtcaacg aaagaatgac     1620
agccaaagtt attttatgca aaagtctgga tggagccaag aaaaatttca aacgaccatt     1680
caaaaaaatc gtcgtttttt agctaagtta ttatactatt acgaacaaga tggcatatgt     1740
gcctatacag gactgtctat ttctcctgaa ttattggtta gtgattcaac agaaattgat     1800
catattattc caatttcgat tagcttagat gattctatta ataataaagt actggtttta     1860
agtaaagcta atcaagtcaa aggacaacaa acaccatatg atgcatggat ggacggttct     1920
ttcaaaaaaa ctaacgggaa atttagcaac tgggatgact atcaaaaatg ggtggaaagt     1980
cgccatttta gtcataaaaa agaaaataat ttattggaaa cgcggaatat ttttgacagt     2040
gagcaagtcg aaaaattttt agctagaaat ctgaatgata cgcgttatgc cagtcgttta     2100
gttttaaata ccttacagag tttttttgcg aatcagggaa cgaaagttcg agtagtgaac     2160
ggcagtttta ctcatacttt acgtaaaaaa tggggtgccg acttagataa aactcgtgaa     2220
acacatcatc atcatgccgt tgatgcaaca ttgtgtgcag tcactccgtt tgtcaaggtt     2280
agtcgttatc actatgcagt gaaggaagaa actggtgaaa aagtcatgcg tgaaatcgat     2340
ttcgaaactg gtgaaattgt cgatgaaatg tcttaccagg aattcaaaaa atcaaagaag     2400
tatgaacgaa aaacctatca ggtaaaatgg cctaattttc gtgagcaatt gaagccagta     2460
aacctccatc caagaattaa attttctcac caagtggatc gtaaagctaa ccgcaaactc     2520
agtgatgcca ctatttattc tgttcgagag aaaacggaag tcaaaacgct gaaaagtggt     2580
aaacaaaaaa taacgactga cgagtacaca atcggtaaaa tcaaagacat ttacacggta     2640
gatggttggg aagccttcaa gaaaaaacaa gataaacttt taatgaaaga tcttgacgaa     2700
aagacctatg aacgattgtt gtctattgca gaaacaactc ctgattttca agaagtggaa     2760
gaaaaaaatg gtaaggtaaa gcgtgttaaa cgttcaccgt ttgctgttta ctgtgaagaa     2820
aatgatattc cagcgattcg gaaatatgcg aaaaaaaaca atggaccact tattcgtagt     2880
ttgaagtatt atgacggtaa attgaataaa catattaata tcaccaagga ttcacaagga     2940
cgacctgttg aaaaaactaa aaatggtcgc aaagttacac tacaaagttt aaaaccatat     3000
cgctacgata tttatcaaga tttagaaact aaggcttatt atacagtaca actatattat     3060
tctgacttac gttttgtgga aggtaagtat ggaatcacag aaaaagaata catgaaaaaa     3120
gtcgccgaac agacaaaggg acaagtggtg cgtttctgtt tttctttaca aaaaaatgat     3180
ggtttggaaa ttgaatggaa agatagccaa cgctatgatg tgcgttttta taatttccaa     3240
agtgctaata gtattaactt taaagggtta gaacaagaaa tgatgccagc agaaaatcaa     3300
tttaagcaaa aaccttataa taatggagcc atcaatttaa atatcgctaa atatggcaaa     3360
gaaggcaaaa agttacgaaa attcaataca gatattttag gaaagaaaca ttatctgtat     3420
tatgaaaaag aaccaaagaa tattattaaa taa                                  3453

<210>  34
<211>  4371
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Cas endonuclease of Locus 16

<400>  34
atggtttccc ataaaatgat tacttttttt ctctttattt ttatgcttta tgaaaaccaa       60
atagcaatga ctaaaaatat actaggatta gacttaggaa cgaactcaat aggatgggca      120
ttgataaaac aggattttga aaacaaacaa ggtgaaattc ttgggatggg aagcagaatt      180
atacctatgt ctcaggatat tttgggggaa tttggaaaag gaaattctgt ttctcaaact      240
gcttctcgga ctagctatag aggtgtgaga agattacgtg aaagatttct tttgcgaagg      300
gaaagattac atagagtttt aaatgttctg aactttttac ccgcacatta tgcttctcag      360
atagattttg aaaagaggtt tgggaaattc aaagaagaaa ctgagcctaa gttggtttat      420
gacgtgaatg aatttatttt taaaaattcg tttgaagaaa tgctttatga ttttagaaag      480
tatcagccac agcttttaga aaatgataaa aaagttccct atgactggac gatttattat      540
ttacgtaaca aagccttaac ccaaaaaata gagaaagaag aacttgcttg gattctttta      600
aattttaatc agaagcgtgg ttattatcaa ttacgtgggg aagattttga agaagaaaaa      660
gataaaactt ttgtacgcct aaaagttgat aaaattgttg attcgggaga cactataaag      720
ggcaaaatat tatatgatgt ttatttcgaa aatggctgga aatatgataa acagattgta      780
aaaacggaag attggataga acgtgtaaaa gaatttattg ttacagaatc attcttaaaa      840
aacggcgata taaaaagaac ttttaaagct gttgattctg aaaaggattg gattgctatc      900
aaaactaaaa cagaacaaga aattgataat tcgaataaaa ccgttgggac atacatttat      960
gaaacacttc ttcgaaatcc aaaacaaaaa attaaaggaa aattggttcg tacgattgaa     1020
agaaaattct ataaagatga gctgaaacag attctggaaa aacaaaaaga atttcatctt     1080
gaattaaaga atgatgattt atatagtgat tgtattcgtg aattgtatcg aaataatgaa     1140
gcgcatcaat tgacgttgag tagaaaagat tttgttcatc ttttgatgga ggatattatt     1200
ttttatcaaa gacctttaag aagtcataaa tcttctattt caaactgtac tttggaattt     1260
agaaaatata aagatgaaaa tggagcagag catattcaat atttaaaagc gattccaaaa     1320
tcaaatccat attatcagga attcagaatc tggcaatgga tttttaatct caatatttat     1380
aagagagatg acgagcaaaa tcctgttaca aaaaagtttt taaacaccac ccaagatttt     1440
gaaaatctgt ttgaatttct gaataacaga aaagaaattg accaaaaggc tttactcaaa     1500
catcttaaaa taaatgagaa aacgcatcgt tggaagtatg tagaagacaa aaagtatcct     1560
tgcaacgaaa ccaaaacaat gatttcatca aggttggata aagttgaaaa tatttctgaa     1620
aacttcctga caagagaaat tgaacagaag atttggcata ttatctattc tgtcaacgat     1680
aaaattgaat atgaaaaagc tttaaaatct tttgccaata aaaataatct ggacgaagtt     1740
tctttctttg aagcttttaa aaaattccca ccttttaaaa gcgaatatgg ttctttttct     1800
gaaaaagcaa taaagaaact gttgccttta atgcgattgg gaaaatattg gaattatgct     1860
gatattgata aatattcaaa agacagaatt cagaaaatta tcaatggaga atatgatgaa     1920
aatatcaaag acaaggtaag ggaaaaagca gttcatctta cgactgaaaa tgattttcaa     1980
ggtcagcaat tgtggctggc tcaatatatt gtttacggaa ggcattctga agcttcaatg     2040
attggaaaat ggaattctgc cgatgatttg gaagagtttt taaaagagtt taagcaacat     2100
tcgcttcgaa atccgattgt tgagcaggtc attaccgaaa ctttgcgcgt tgtaaaagat     2160
atttggttga aatacggaaa tggagcgaaa gatttcttta acgaaattca tattgagttg     2220
ggaagagaaa tgaaacttcc tgcagatgat agaaaaaaac taacgaacca aatttctgaa     2280
aacgaaaata ccaatcttcg tatcaaggct ttgctggctg aaatgataaa cgaccattct     2340
gttgaaaatg ttcgtccgtt ttcgcctatg caacaggaaa ttttgaaaat ttatgaagat     2400
ggagtattga attcaggtat tgaaattgaa gatgaatatt tgaaaatcag caaaaccgca     2460
caaccttctc cgtctgattt gaagagatac aaactttggt tggaacagaa atacaaatcg     2520
ccttacacag gacaaattat tcctttaaat aaattgttta cgccagaata tgaaattgaa     2580
catatcatac ctcaaagccg atattttgat gacagcttta gtaataaaat tatttgtgaa     2640
tcagccgtta ataaattgaa ggataattat atcggacttg gatttattaa gcaattcgga     2700
gggactatta ttgagcttgg ttttggaaaa aatgtaaagg tttttgaagt cgaagaatat     2760
gaagattttg tcaaaaaaca ttatgcaaat aatcgaagta agagaaataa acttttatta     2820
gaagaaattc ctgaaaaaat gattgaacgt cagttgaatg atacacgtca tatcagtaag     2880
tatatttcag gtgtgctttc caatattgta agagtagaag atggaacaga tgaaggtgta     2940
aattctaaaa atattgttcc cggaaacgga aaaatcacaa ctcaattaaa acaggattgg     3000
ggactgaatg atgtttggaa tgatttgata ctgccacgtt ttgaaagaat gaatcaacta     3060
accaattcaa cagattttac agcttggaat gaaaatcatc aaaagtattt gccaactgtt     3120
ccgattgagt tttcaaaagg attttcaaag aaaagaatcg accatcgtca tcacgctttg     3180
gatgctttgg tgattgcttg tgctacaaaa gaccacgtaa atttattgaa taatcaatct     3240
gcaaaatcgg agacgaaacg ttacgatttg aaaaagagat tgatgaagtt tgaaaaagtt     3300
gtttacaatc atacacaaac aggagagaaa atcgaaagag atgttccgaa aaagtttttg     3360
aaaccttggg aaaactttac ggttgaagct aaaaacagtt tggagaaaat aattgtaagc     3420
tttaagcaaa atctcagagt aatcaataaa gctacaaatt attatgaaaa atatgtggag     3480
aaagatggct tgaaaacgaa agaaagggta gagcagaccg gaacgaactg ggcgataaga     3540
aaatcattgc acgaagaaac cgtttcaggg aaaattaact tgccttgggt ggaaacaagc     3600
aatggagaat ttattactgc cacaagaaag tctttggaca caagcttcaa tttggaaaaa     3660
atcaaaaaaa ttacggatat cggaattcag aaaattctca gaaattatct tgaggcaaaa     3720
gatggcaatc ccgaattggc tttttcgcca gaaggaattg aagatctgaa taaaaatgtt     3780
gaaaagtata atgatggtaa atcacatcag ccaattatca aagttcgtgt ttatgaaaaa     3840
ggcaaaggaa ggtttgtctt agggcaaaca ggaaataaaa ttgataaata cgttcagggt     3900
tcccctaact tatttttcgc aatatataaa gatgataatg gtaaaaaaag ttatgaaagt     3960
attcgtttag atattgcgat tgaaagatta aagcaaggtt tgcaagcagt tccagaaaca     4020
aatcaaaatg gatttgcatt gtatcaaagc ctgtctcctt tagatttagt ttacattccc     4080
acagaggatg aagttgaatc accacatcta attgatttta gtaaattaga taagataaaa     4140
ttggaaagga tttataatgt aaatgacttc tcaggatata caatttactt cagccaaaat     4200
tcatttgcta aaaacattta tcctaaagag atggatatga cctggaacga aaaaaaacaa     4260
aaaccatcag gttcgtttga ttctaaaaca gcttcataca ataaaaaatc gattaaagat     4320
atttttatta aaatgaaaat tgaccgttta ggaaatattt caaaagcgta a              4371

<210>  35
<211>  4389
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Cas endonuclease of Locus 17

<400>  35
atgacaaata tagaagaaaa aatatttaat acaattatgg gaatccgtaa tttgaatgct       60
ttttttattt atattttagg tgatattcaa aacataactg tgatgattaa aaataaactt      120
ggcttagact tgggaacgaa ctccatagga tgggcattga taagacagga ttttgaaaac      180
aaatacggag aaattcttgg gatgggaagc agaattattc cgatgtcaca agatattctg      240
ggcgattttg gaaaagggaa ttctgtttcg caaaccgcag aacgaacaaa atatagaagt      300
gtgagaagat tacgtgaacg atttttattg aggagagaac gactacacag acttttacat      360
cttttaaatt ttcttccaca acattatgct tcacaaattg attttgaaaa aagattcgga      420
aagtttaaag tggaaaccga accaaaactg gcttggaaaa atattgaagg aaaattttca      480
ttccttttcc aaaactcttt caatgaaatg cttgaagatt ttaatgcaaa tggacaggat      540
ttaaaaattc cttacgactg gacaatttat tttctccgaa aaaaagcact ttcacaaaaa      600
attgaaaagg aagaattggc gtggattctt ttaaacttta atcaaaaacg tggatattat      660
caattgcgtg gtgaggaaga ggaagagaat cctaataaac aggttgagtt ttattcttta      720
aaagtcatag acgttttagc agatgaacct caaaaaggaa aatctgatat ttggtattct      780
ttgattttag agaatggatg gatttacaga cgttcaagta aaattccatt atttgactgg      840
aaagataaaa caagagattt tattgtaacc acggacttga atgatgatgg aagcattaaa      900
aaagataaag acggaaatga aaaaagaagt ttccgtgcgc cgggtgagaa tgattggact      960
ttggtaaaaa agaaaaccga gcaggaaatc gagcaatctc acaaaaccgt tggaacctac     1020
atttacgaag cacttcttga taatcccaaa caaaaaataa agggaaaact gattcgtacc     1080
attgaaagaa aattttacaa agaagaactc agacagattt tagaaaagca aaaggaattt     1140
catcaggaat tacaaagtga tgatttgtat aatgattgta ttcgtgagtt gtaccgaaac     1200
aacgaatcac atcaacttat tttgagcaag aaagattttg ttcatctttt gatggaggat     1260
cttattttct accaaagacc gctgagaagc cagaaatctt ctgtttctaa ctgtaccttg     1320
gagttcagaa agtataaaga tgaaaatgga gcagaacata tacaatattt aaaagccatt     1380
ccgaaatcta atccttatta tcaggaattc cgcctttggc aatggatcta caatttaaac     1440
atttatagaa aagatgatga agcgaatgtt accaaagatt ttttaaatac gacccaagat     1500
ttagaaaatc tgtttgagtt tttaaatatc agaaaagaaa ttgaccaaaa aggattacta     1560
aaacatttta aactcaatga aaaaaaacat cgttggaatt ttgtagaaga aaagaaatat     1620
ccttgcaacg aaactaaaac gatgatttct tctcgattgg ataaagtgga taatatttct     1680
gatgatttcc tgacaaggga cattgagcag aaaatttggc acatcattta ttccgttaat     1740
gataaagtag agtacgagaa agccttaaaa tcttttgcga gaaagtatca tctggatgaa     1800
agttcttttt ttgaggcttt cagaaaattt ccgccattta aaagtgaata tggttccttt     1860
tcggaaaaag caattaagaa attgttggct ttgatgcgat taggaaaata ttggaactat     1920
gcagatgttg ataaattttc aaaagacaga attcagaaaa tcattaacgg agaatatgat     1980
gaaaatatta aagataaagt gagagaaaaa gcaataaatc tcacatcaga aaatgatttt     2040
caggggttac aattgtggtt ggctcaatat ataatatatg gaaggcattc agaagcatct     2100
atgattggaa aatggaattc tgcggatgat ttagaaatgt ttttaaaaga ttttaaacaa     2160
cattcgcttc gcaatccgat tgtagaacag gtgattacag aaactcttcg tgtggtaaaa     2220
gatatttggt taaaatatgg aaatggagca aaagattttt tcaatgaaat tcatattgag     2280
ttgggaagag aaatgaagct tcctgcgggt gatcgaaaaa aactcacgaa tcaaattacc     2340
gaaaacgaaa acaccaatct ccgcatcaaa gctctattgg cagaaatgat gaatgatcat     2400
tcagtagaaa atgttcgtcc gttttcgcct atgcaacagg aaattttgaa aatctatgaa     2460
gacggcgttt taaattcagg tattgagatt gaagatgaat atttgaaaat aagcaaaacg     2520
gcacagcctt cttcttcaga tttaaaaaga tataaacttt ggctggaaca aaaatataaa     2580
tcaccttata ccgggcaaat tattccatta aataaattat tcacaccgga atacgaaatt     2640
gaacacatta ttccgcaaag ccgatatttt gatgacagtt ttagcaataa agtaatttgc     2700
gagtcggcgg ttaataaatt gaaagataat tatatcggac ttggatttat taagcagttt     2760
ggaggaacta ttattgagct tggtttcggg aaaagtgtaa aggtatttaa tatagaagag     2820
tatgaagatt ttgtaaagaa acattatgca aacaatagag gcaaaagaaa caagcttttg     2880
atggaagata ttcctggaaa aatgattgaa cggcaattga acgatacccg ctatatcagt     2940
aaatatgttt ccggaattct ttccaatatt gttcgggtag aagacggttc agacgaaggg     3000
gttaattcta aaaacatcgt tccgggaaat ggaaaaatca ctacccaact gaaacaagat     3060
tgggggttga atgatgtttg gaatgatata attttaccac gttttgaaag aatgaatcaa     3120
cttactaatt caaaagattt taccgcctgg aatgaaaatc atcaaaagtt tttacctacc     3180
gttccaattg agttttccaa aggattttca aagaaaagaa ttgaccatcg tcatcatgct     3240
ttagatgctt tggtgattgc ctgtgccaca aaagatcacg tgaatttatt aaataatcaa     3300
tcggcaaaat cggataccaa acgatacgat ttgaaaaaga aattgatgaa gtttgaaaaa     3360
gtagtttatt atcatacgca aacaggggag aaaatagaaa gggaaatacc gaaacaattt     3420
ttaaaaccgt gggaaaactt tacagttgac gcaaaacata atctggaatc tattattgta     3480
agttttaagc aaaaccttcg tgttattaat aaagcaacta attattacga aaagtatgtt     3540
gaaaaagacg gtacaaaaaa taaggaaaga gtagagcaga ccggaacaaa ctgggcgatt     3600
agaaagccaa tgcataagga tacggtttcc ggaaaagtag atttaccttg ggtgaaagtt     3660
ccaaaaggaa aaattttaac agcaacgagg aaaagccttg atatttcatt tgatttaaaa     3720
tcaatagcat ctattactga tacagggatt cagaaaattc tcagaaatta tctgaaattc     3780
aaaggcagtc cggaacttgc attttctcca gaaggaatcg aagatctgaa taagaatatt     3840
gagaagtaca atgatggaaa atctcatcaa ccgatcaata aagtaagagt ttttgaactg     3900
ggaagtaaat ttcaggtagg acaaaccgga aataaaaaag ataaatatgt agaagctgca     3960
aaaggaacca atctgttttt tgctgtttat gaaaatgaaa atagaaacag aagttatgaa     4020
accattcctt tgaatgaggt tatagaaaga caaaagcaag gtttatctgt ggttgactta     4080
aaaggaacaa ttgatttttt tctttgcccg aatgatttag tttatattcc ttcagaagat     4140
gaacttgaaa atagtagcaa cattgacttc aaaaatttta aagaagaaca aaacaaaaaa     4200
atttataaag tagttagttt tagtggaagt cagttgtttt ttataagaca ggaaattgcc     4260
atatcaattg taaataaagc agaattttcc accttgaata aaatggagcg tagtattgat     4320
gggttaatga ttaaggaaaa ttgtatcaaa ttaaaagtag accgtttggg aaatatttct     4380
aaagcatag                                                             4389

<210>  36
<211>  4323
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Cas endonuclease of Locus 18

<400>  36
atgaaaaata tacttggact ggacttggga acaaactcta ttgggtgggc tttagtaaaa       60
caggattttg aaaacaaaca aggtgaaatt cttggaatgg ggaccaggat aattccgatg      120
tctcaagata ttttgggcga ttttggtaaa gggaattctg tttcgcaaac tgcggaacgt      180
acaaaataca gaagtgtaag aagattacgt gaacgatttc ttctacgaag ggagaggctt      240
cacagggttt taaacatttt gaattccctt ccagaacact atgcttcaca gattgatttt      300
gaaaaacgat ttgggaagtt caaagttgaa actgaaccaa aattggcctg gaaaaatatt      360
gaaggacatt tttcatttct gttccaaaac tctttcaacg agatgcttga agattttaaa      420
acgaacggac aggatttaaa aataccgtac gactggacga tttattatct ccgtaaaaag      480
gcactttctc aaaaaattga aaaagaggag ttggcctgga ttcttttgaa ttttaaccaa      540
aaacgtggat attatcaatt gcgtggggaa gaagaggaag aaaatcctaa taaaattgtt      600
gaattttatt ctttaaaagt tgtggatgtt ctagcagatg agccacaaaa aagcaaatca      660
gatatatggt attctttggt tttagaaaat ggatggattt acagaagggc aagtaaaata      720
tcgttgtttg attggaaaga taaaacaaga gattttattg taacaactga tttgaatgat      780
gatggaagtg ttaaaacaga caaagacgga aatgaaaaaa gaagtttccg ggcaccgggt      840
gagaacgatt ggactttggt aaagaagaaa acagagcagg aaatcgagca gtctcataaa      900
accgttggaa tatatattta cgaaactctc cttaataatc ccaaacaaaa aatcaaaggg      960
aaactagttc gtacgattga aagaaaattc tataaagaag aactcaggca gatattagaa     1020
aagcaaaagc agttccatca ggaattacaa aatgatgatt tatataattg ttgtattcgc     1080
gagttgtaca gaaataatga agcccatcaa ctgactttaa gtaaaaaaga ttttgtacat     1140
ctttttatgg aggatattgt tttctaccaa agaccgttga gaagccagaa gtcttctatt     1200
tccaactgta ctttggaatt cagaaaatac aaagatgaaa atggagcaga acatacacaa     1260
tatttaaaag ccattccaaa atcgaatcca tattatcagg agtttcgtct ctggcaatgg     1320
atttttaatc ttaatctata taaaaaagat aatgatgaaa acgttatcaa agaattttta     1380
accactaccc aggatatcga aaatctgttt gagtttttaa ataacagaaa agagattgat     1440
caaaaagctc tattgaaaca ttttaagctc aatgagaaaa cacatcgttg gaattttgta     1500
gaggataaaa aatacccctg caatgaaacg aagacgatga tttcaactcg attggaaaaa     1560
gtagaaaata tttccgatga ttttctgacc agggaaatcg aacaacagat ttggcatatt     1620
atctattctg tcaatgataa aatagaatac gaaaaagcct taaaaacctt tgcatcaaaa     1680
catcatctag acgaaagttc ttttttcgag gctttcagaa aatttccacc atttaaaagc     1740
gaatatggtt cctattcgga aaaagcaatt aagaaattgt tgcctataat gcgattgggc     1800
aaatattggg attatgccaa tattgatcag tcttcaaaag acaggattaa gaagatcatt     1860
aatggagaat atgatgaaaa tataaaagat aaggtaagag aaaaggcagt ccatcttacg     1920
aatgaaaatg atttccaggg tttacaattg tggctggctc aatatattgt atatggaaga     1980
cattcggaag catcaataac agcgaaatgg aattcagctg atgatttgga agaattttta     2040
aaagatttta aacaccactc gcttcgcaat ccaattgtag agcaggtcat tactgagact     2100
ttacgtgttg tgaaagatat ttggctaaaa tacggaaaag gagcaaaaga cttcttcaat     2160
gaaattcata tagagttggg aagggaaatg aaacttccgg ctgaagatag aaagaaactt     2220
acgagccaaa ttattgaaaa tgaaaatacg aatctccgca tcaaagctct attagctgaa     2280
atgatgaatg atcatgctgt agaaaatgtt cgtccgtttt caccccagca acaagaaatt     2340
ctgaaaattt atgaggacgg tgttttaaat tcaggcattg aaattgaaga tgaatattta     2400
aaaataagca aaacggcgca accttctcct tcagatttaa aacggtataa actttggctg     2460
gaacagaaat acaaatcgcc ttataccggg caaatgattc cactaaataa attgtttacg     2520
ccagaatatg aaattgaaca tattatccca caaagtcgat actttgatga tagttttagt     2580
aataaaatta tttgtgaatc ggcagttaac aaattgaagg ataattatat cggacttgga     2640
tttattaagc agtttggagg aactattatt gaacttggtt tgggtaaaag cgtgaaggtt     2700
tttgatattg atcaatacga agattttgtt aagaagcact acgccaataa ccgaagtaaa     2760
agaaataaac ttcttttaga agatattcct gaaaaaatga ttgaacgtca gatcaatgat     2820
actcgttata tcagtaaata tatttccggt atactttcta atattgttcg cttagaagat     2880
ggttcggatg aaggagtaaa ttctaaaaac attgttcccg gaaatggaaa aattactacc     2940
caattgaaaa aggactgggg gttgaatgat gtttggaatg acttgatttt accccgtttt     3000
aaaagaatga atcagttgac caattcgacg gattttaccg cctggaacga aaattttcaa     3060
aagtttttgc cgaccgttcc aattgagtat tcgaaaggtt tttctaaaaa aaggatcgac     3120
catcgtcatc atgctctaga cgctttggta attgcttgtg ctacaaagga tcacgtaaat     3180
ttattaaata atcaatcggc aaaatcggaa accaaacgct atgatttgaa aaagaaatta     3240
atgaagtttg aaagagttgt ttatttccat acgcaaacag gggagaagat cgaaagagaa     3300
gtgccaaaac aatttttaaa accctggaaa aattttactg ttgatgctat gcataatttg     3360
gaaacggtta ttgtaagttt taaacaaaac cttagggtca ttaataaagc aacgaattat     3420
tacgaaaaat atgtagagaa agatggtgta agaaataaga caagaataaa gcaaaaggga     3480
ataaattggg cgattagaaa accaatgcat aaagatacgg tttccggtaa agtagattta     3540
ccttgggtaa aagtcccaaa aggaaaaatt ttaacagcaa caaggaaaag ccttgacgct     3600
tcattcgatt taaaatcaat aggctccatt actgatacag ggattcaaaa aattctcaaa     3660
aattatttaa tgcataaaga cggaaatacg gaattggctt tttcacccga aggaattgaa     3720
gatttgaata aaagtattga gaagtataat gatggtaaac ctcatcagcc catcaacaaa     3780
gtaagggttt ttgaactggg tagtaaattt caggtaggac aagccggaaa taaaaaagat     3840
aaatacgtag aagccgcaaa aggaaccaat ttgttttttg gagtgtacga agataaaaac     3900
ggcaagagaa gctatgaaac cattcctttg aatgaggtga ttgaaaggca aaagcaaggt     3960
ttacctgtgg ttgacttaag aagtacaaat gatttctatt tatgcccgaa tgatttggtt     4020
tatattctat ctgatgatga gcggggtaat atgacaaata tcgattttga aagcctttct     4080
gatgaacaag ttaaaaggat atataaattt gttagttgta caggaggtga gggacatttt     4140
attccttacg caaatgcgac agaaataata aaaaatgaaa atggtacaaa tagtaaaagt     4200
gagagaatgc agaatttcta tgatgggagt tgtatgtttg ataaaaacgc caagcccatt     4260
atgataaaag aaaactgtgt aaaacttaaa gtcgaccgtt tagggaacat tgcaaagata     4320
taa                                                                   4323

<210>  37
<211>  4323
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Cas endonuclease of Locus 19

<400>  37
atgaaaaata tacttggact ggacttggga acaaactcta ttgggtgggc gttggtaaaa       60
caggattttg aaaacaaaca aggtgaaatt cttggaatgg gagtcaggat aattccgatg      120
tctcaagata ttttgggcga ttttggtaaa gggaattctg tttcgcaaac cgcggaacgt      180
acaaaatata gaagtgtgag acgattacgt gaacgatttc ttctacgaag ggagaggctt      240
cacagggttt taaatatttt gaatttcctt ccagaacact atgcttcaca gattgatttt      300
gaaaaacgat ttgggaagtt caaagttgaa actgaaccaa aattggcctg gaaaaatatt      360
gaaggacagt tttcatttct gttccaaaac tctttcaacg agatgcttga agattttaaa      420
gcgaacggtc aggatttaag aataccgtac gactggacga tttattatct tcgtaaaaaa      480
gcactttatc aaaaaattga aaaagaggag ctggcctgga ttcttttgaa ttttaaccaa      540
aaacgtggat attatcaatt gcgtggggaa gaagaggaag aaaatcctaa taaacttgtt      600
gaattttatt ctttaaaagt tgtagatgtt cttgcagatg agccgcaaaa aagcaaatca      660
gatatttggt attctttggt tttagaaaat ggatggattt acagaagggc aagcaaaata      720
ttgttgtttg attggaaaga taaaacaaga gattttattg taacaactga tttgaatgat      780
gatggaagtg ttaaaacaga caaagaagga aatgaaaaaa gaagtttcag ggcaccgggt      840
gagaacgatt ggactttggt aaagaagaaa accgagcaga aaatcgagca gtctcataaa      900
accgttggaa tgtatatata cgaaacgcta cttgctaatc ctaaacaaaa aatcaaagga      960
aaattagttc gtacgattga aagaaaattt tacaaagaag agcttagaca gatattagag     1020
aagcaaaagg agtttcatca ggaattacaa aatgatgact tatataatga ttgtattcgt     1080
gagttgtaca gaaacaatga agctcaccaa ctgactttaa gcaaaaaaga ttttatacat     1140
ctttttataa aggatattgt tttctaccaa agaccgttga gaagccagaa gtcttctatt     1200
ttcaactgta ctttggaatt cagaaaatac aaagatgaaa atggagcaga acatacgcaa     1260
tatttaaaag caattccaaa atcgaatcca tattatcagg aatttcgtct ttggcaatgg     1320
atttttaatc ttaacctata taaaaaagat aatgatgaaa acgttatcaa agaattttta     1380
accactaccc aagatgtcga aaatctgttt gagtttttaa acaacagaaa agaagttgat     1440
caaaaaactt tattgaaaca ttttaagctc aatgagaaaa cacatcgctg gaattttgta     1500
gaggataaaa aatacccctg caacgaaaca aagacgatga tttcaacccg attgcagaaa     1560
gtagaaaata tttccgggga ttttctgacg agggaaatcg aacaaaagat ttggcatatt     1620
atatattctg tcaatgataa aattgaatac gaaaaagcct taaaatcctt tgcgttaaaa     1680
catcaacttg acaaaagttc ttttttcgag gctttcagaa aatttccacc atttaaaagc     1740
gaatatggtt ccttttcgga aaaagcaatt aagaaattgt tgcctttaat gcgattgggt     1800
aagtattggg attatgccaa tattgataag ttttcaaaag acaggattca gaaaatcatt     1860
aatggagaat atgatgaaaa tataaaagat agggtaagag aaaaggcggt ccatcttagg     1920
agtgaagatg atttccaggg tttacaattg tggctggccc aatatattgt atatggaaga     1980
cattcggaag catcaataac agggaaatgg aattcagctg atgacttgga agaatttttg     2040
aaagatttta aacaccactt gcttcgcaat ccaattgtag agcaggtcat tacagaaact     2100
ttacgtgttg taaaagatat ttggctaaaa tatggaaaag gagcaaaaga tttcttcaat     2160
gaaattcata tagagttggg aagggaaatg aaacttccag ctgacgatag aaagaaactc     2220
acaaaccaga ttactgaaaa cgaaaatacg aatctccgca ttaaagctct attaacagaa     2280
atgatgaatg atcatgctgt agaaaatgtt cgtccgtttt cgccccagca acaagaaatt     2340
ctgaaaattt atgaggacgg cgttttaaat tcaggcattg aaattgaaga tgaatattta     2400
aaaataagca aaacggcgca accttttcct tcagatttaa aacggtataa actttggctg     2460
gaacagaaat acaaatcgcc ttatactggg caaattattc cattaaataa attgtttaca     2520
ccagaatatg aaattgaaca cattattcca caaagccgat actttgatga cagttttagt     2580
aataaaatta tttgtgaatc ggcggttaac aaattgaaag ataattatat cggacttgga     2640
tttattaagc agtttggagg aactattatt gaacttggtt tcgggaaaag cgtaaaggtt     2700
tttgatattg atgaatatga agattttgtc aagaagcact acgccaataa ccgaagtaaa     2760
agaaataagc ttctcttaga agatattcct gaaaaaatga ttgaacgtca gatcaatgat     2820
actcgttata tcagtaaata tatttccggt atactttcta atattgttcg cttagaagat     2880
ggttcggatg aaggagtaaa ttctaaaaac attgttcccg gaaatggaaa aattactacc     2940
caattgaaaa aagactgggg gttaaatgat gtttggaatg acttgatttt accccgtttt     3000
aaaagaatga atcagctgac caattcgaca gattttaccg cctggaacga aaattttcaa     3060
aagtttttgc cgaccgttcc aattgaatat tccaaaggtt tttctaaaaa aagaatcgac     3120
catcgtcatc atgctttaga cgctttggta attgcttgtg ctacaaagga ccacgtaaat     3180
ttattaaata atcaatcggc aaaatcggaa accaaacgct acgatttgaa aaagaaatta     3240
atgaagtttg aaagagttgt ttatctccat atgcaaacag gggagaaaat cgaaagagaa     3300
gtgccaaaac aatttttaaa accttgggaa aattttactg tagatgttaa gtataatttg     3360
gacatggtta ttgtaagttt taagcaaaac cttagggtca ttaataaagc aacgaattat     3420
tacgaaaaat atgtagagaa ggatggtgca agaaataaga caagagtaga gcaaaaggga     3480
ataaattggg ctattagaaa accaatgcat aaagatacgg tttccggtaa agtagattta     3540
ccttgggtaa aagttccaaa aggaaaaatt ttaacagcga cgaggaaaag ccttgatgct     3600
tcattcgatt taaaatcaat tgcctccatt actgatacag ggattcaaaa aattctcaaa     3660
aattatttaa tgcttaaaga tggaaaccct gaattggctt tttcacccga aggaattgaa     3720
gatttgaata aaagtattga gaagtacaat gatggcaaac ctcatcaacc catcaataaa     3780
gtaagggttt ttgaactggg tagtaaattt cagataggac aagccggaaa taaaaaagat     3840
aaatacgtag aagccgcaaa aggaaccaat ttgttttttg cagtgtacga agatgaaaac     3900
ggcaagagaa gctatgaaac tattcctttg aatgaggtga ttgaaaggca aaagcacggt     3960
ttacctgtgg ttgatttaac aagtacaaat gatttctatt tatgcccgaa tgatttggtt     4020
tatattctat ctgatgatga gcgggataat atgacaaata acgattttga aaacctttct     4080
gacgaacaag ttaaaaggat atacaaattt gttagttgta caggaggtga ggggcatttt     4140
attccttacg caagtgcgac agaaataata aaaaatgaaa acggtacaaa tagtaaaagc     4200
gagagaatac agaatttcta tgatggtagt tgtatgcttg ataaaaacag caagcccatt     4260
atgataaagg aaaactgtgt aaaacttaaa gtcgaccgtt taggtaacat ttcaaagata     4320
taa                                                                   4323

<210>  38
<211>  4323
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Cas endonuclease of Locus 20

<400>  38
atgaaaaata tacttggact ggacttggga acaaactcta ttgggtgggc gttggtaaaa       60
caggattttg aaaacaaaca aggtgaaatt cttggaatgg gagccaggat aattccgatg      120
tctcaagata ttttgggcga ttttggtaaa gggaattctg tttcgcaaac cgcggaacgt      180
acaaaatata gaagtgtgag acgattacgt gaacgatttc ttctacgaag ggagaggctt      240
cacagggttt taaatatttt gaatttcctt ccagaacact atgcttcaca gattgatttt      300
gaaaaacgat ttgggaagtt caaagttgaa actgaaccaa aattggcatg gaaaaatatt      360
gaaggacagt tttcatttct gttccaaaac tctttcaacg agatgcttga agattttaaa      420
gcgaacggtc aggatttaag aataccgtac gactggacga tttattatct tcgtaaaaaa      480
gcactttatc aaaaaattga aaaagaggag ctggcctgga ttcttttgaa ttttaaccaa      540
aaacgtggat attatcaatt gcgtggggaa gaagaggaag aaaatcctaa taaacttgtt      600
gaattttatt ctttaaaagt tgtagatgtt cttgcagatg agccgcaaaa aagcaaatca      660
gatatttggt attctttggt tttagaaaat ggatggattt acagaagggc aagcaaaata      720
ttgttgtttg attggaaaga taaaacaaga gattttattg taacaactga tttgaatgat      780
gatggaagtg ttaaaacaga caaagaagga aatgaaaaaa gaagtttcag ggcaccgggt      840
gagaacgatt ggactttggt aaagaagaaa accgagcagg aaatcgagca gtctcataaa      900
accgttggaa tgtatatata cgaaacgcta cttgctaatc ctaaacaaaa aatcaaagga      960
aaattagttc gtacgattga aagaaaattt tacaaagaag agcttagaca gatattagag     1020
aagcaaaagg agtttcatca ggaattacaa aatgatgact tatataatga ttgtattcgt     1080
gagttgtaca gaaacaatga agctcaccaa ctgactttaa gcaaaaaaga ttttatacat     1140
ctttttataa aggatattgt tttctaccaa agaccgttga gaagccagaa gtcttctatt     1200
tccaactgta ctttggaatt cagaaaatac aaagatgaaa atagagcaga acatacgcaa     1260
tatttaaaag caattccaaa atcgaatcca tattatcagg aatttcgtct ttggcaatgg     1320
atttttaatc ttaacctata taaaaaagat aatgatgaaa acgttatcaa agaattttta     1380
accactaccc aagatgtcga aaatctgttt gagtttttaa acaatagaaa agaagttgat     1440
caaaaaactt tattgaaaca ttttaagctc aatgagaaaa cacatcgctg gaattttgta     1500
gaggataaaa aatacccctg caacgaaaca aagacgatga tttcaacccg attgcagaaa     1560
gtagaaaata tttccgggga ttttctgacg agggaaatcg aacaaaagat ttggcatatt     1620
atatattctg tcaatgataa aattgaatac gaaaaagcct taaaatcctt tgcgttaaaa     1680
catcaacttg acaaaagttc ttttttcgag gctttcagaa aatttccacc atttaaaagc     1740
gaatatggtt ccttttcgga aaaagcaatt aagaaattgt tgcctttaat gcgattgggt     1800
aagtattggg attatgccaa tattgataag ttttcaaaag acaggattca gaaaatcatt     1860
aatggagaat atgatgaaaa tataaaagat agggtaagag aaaaggcggt ccatcttagg     1920
agtgaagatg atttccaggg tttacaattg tggctggccc aatatattgt atatggaaga     1980
cattcggaag catcaataac agggaaatgg aattcagctg atgacttgga agaatttttg     2040
aaagatttta aacaccactt gcttcgcaat ccaattgtag agcaggtcat tacagaaact     2100
ttacgtgttg taaaagatat ttggctaaaa tatggaaaag gagcaaaaga tttcttcaat     2160
gaaattcata tagagttggg aagggaaatg aaacttccag ctgacgatag aaagaaactc     2220
acaaaccaga ttactgaaaa cgaaaatacg aatctccgca ttaaagctct attaacagaa     2280
atgatgaatg atcatgctgt agaaaatgtt cgtccgtttt cgccccagca acaagaaatt     2340
ctgaaaattt atgaggacgg cgttttaaat tcaggcattg aaattgaaga tgaatattta     2400
aaaataagca aaacggcgca accttctcct tcagatttaa aacggtataa actttggctg     2460
gaacagaaat acaaatcgcc ttatactggg caaattattc cattaaataa attgtttaca     2520
ccagaatatg aaattgaaca cattattcca caaagccgat actttgatga cagttttagt     2580
aataaaatta tttgtgaatc ggcggttaac aaattgaagg ataattatat cggacttgga     2640
tttattaagc agtttggagg aactattatt gaacttggtt tcgggaaaag cgtaaaggtt     2700
tttgatattg atgaatatga agattttgtc aagaagcact acgccaataa ccgaagtaaa     2760
agaaataagc ttctcttaga agatattcct gaaaaaatga ttgaacgtca gatcaatgat     2820
actcgttata tcagtaaata tatttccggt atactttcta atattgttcg cttagaagat     2880
ggttcggatg aaggagtaaa ttctaaaaac attgttcccg gaaatggaaa aattactacc     2940
caattgaaaa aagactgggg gttaaatgat gtttggaatg acttgatttt accccgtttt     3000
aaaagaatga atcagctgac caattcgaca gattttaccg cctggaacga aaattttcaa     3060
aagtttttgc cgaccgttcc aattgaatat tccaaaggtt tttctaaaaa aagaatcgac     3120
catcgtcatc atgctttaga cgctttggta attgcttgtg ctacaaagga ccacgtaaat     3180
ttattaaata atcaatcggc aaaatcggaa accaaacgct acgatttgaa aaagaaatta     3240
atgaagtttg aaagagttgt ttatctccat gtgcaaacag gggagaaaat cgaaagagaa     3300
gtgccaaaac aatttttaaa accttgggaa aattttactg tagatgttaa gcataatttg     3360
gacacggtta ttgtaagttt taagcaaaac cttagggtta ttaataaagc aacgaattat     3420
tacgaaaaat atgtagagaa ggatggtgca agaaataaga ctagagtaga gcaaaaggga     3480
ataaattggg ctattagaaa accaatgcat aaagatacgg tttccggtaa agtagattta     3540
ccttgggtaa aagttccaaa aggaaaaatt ttaacagcga cgaggaaaag ccttgatgct     3600
tcattcgatt taaaatcaat tgcctccatt actgatacag ggattcaaaa aattatcaaa     3660
aattatttaa tgcttaaaga tggaaaccct gaattggctt tttcacccga aggaattgaa     3720
gatttgaata aaagtattga gaagtacaat gatggcaaac ctcatcaacc catcaataaa     3780
gtaagggttt ttgaactggg tagtaaattt cagataggac aagccggaaa taaaaaagat     3840
aaatacgtag aagccgcaaa aggaaccaat ttgttttttg cagtgtacga agatgaaaac     3900
ggcaagagaa gctatgaaac tattcctttg aatgaggtga ttgaaaggca aaagcacggt     3960
ttacctgtgg ttgatttaac aagtacaaat gatttctatt tatgcccgaa tgatttggtt     4020
tatattctat ctgatgatga gcgggataat atgacaaata acgattttga aagcctttct     4080
gacgaacaag ttaaaaggat atacaaattt gttagttgta caggaggtga ggggcatttt     4140
attccttacg caagtgcgac agaaataata aaaaatgaaa acggtacaaa tagtaaaagc     4200
gagagaatgc agaatttcta tgatggtagt tgtatgcttg ataaaaacag caagcccatt     4260
atgataaagg aaaactgtgt aaaacttaaa gtcgaccgtt taggtaacat ttcaaagata     4320
taa                                                                   4323

<210>  39
<211>  3702
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Cas endonuclease of Locus 21

<400>  39
atgggttcac gtataattcc tttatcaaca agtgataaag aagaatttca aagaggtttg       60
tcaatcacta agaatcaaag tagaacggta agccgtactc agagaaaagg gtatgaccgg      120
aaacaattga agaaaagtaa tttaaagaaa attctaaata aatataatat cttcctttca      180
gaagaattat taaaacttcc aatgcttgat ttgtggaaat tgagaagtga ttctgcaaac      240
ccaaatgaaa atatttcgac tgaacaattg ggacgaattt tatatatgtt gaatcaaaag      300
cgtggctata aatctgcaag aagtgaagca aatgccgata aaaaagatac agattatgtt      360
caggcagtaa aagggcgcta cgcacagctg aaagaaagaa atcaaacaat cggacaatat      420
tttcatgaag aattgcataa tgcaaatgca aacaattctt atttcagaat aaaagaagaa      480
gtttatccga gagaagctta tatagaagag tttgatacga ttattaatgc tcaaaaagat      540
aaacatgatt ttcttacaga cgaagtcgtt catcaattaa gaaatgaaat catttatttt      600
caaagaaaac taaaatctca aaaaggattg atcaatattt gtgaatttga aggctttgag      660
aaaacagttt ttgacaagga caaaaacaaa cacaaagtag tgtctgtcgg tccgaaagtt      720
gcgccgaaaa catctccatt gtttcagctt tgtcgtattt gggaagttgt aaatacaatt      780
accttaaaaa taaagaatcc tgaaggaagc aaatataaat ggggtgagaa aattccaaat      840
ttaattgaga aagagatttt agctgattat ttacttaaaa atgagagttt aagttttacg      900
aagcttcttg aaattttaga attaaataaa aatgatattt atgtaaataa gcaaatatta      960
aaaggtataa aaggcaatga aacttatgct gttcttcaga atattttagg agataatgaa     1020
cttttaaatt ttgatgtttc aattattcca tccaattaca cttcaatttt ggtggacaaa     1080
aaaacgggag agatattgga agagagagca ggtctcgaat tagatgcttc attagaaaaa     1140
gagcctttat accagctgtg gcacaccatt tattccctaa aagatttaga tgaatgcaaa     1200
aatgctttaa ttaaaaggtt tggattcgat gatgagattg ccgaaaagtt gtctcgtatc     1260
aatttcaaca aacaagcttt tagcaataaa tcgaacaaat cgatgagaaa aattcttcct     1320
tttctgatgg aaggctacga ttattctcaa tcttgcagtt tggcggggta caatcattct     1380
aattcgttga cgaaagatga aagagaacag caggtaactt taaacagatt agaacttctt     1440
caaaaaaaca gtttacgaca gcctattgtt gagaaaattc tgaatcagat gataaatgtg     1500
gtgaacgcaa ttcttgagca atacggaaaa ccaactgaaa ttagagttga gctcgcacga     1560
gaccttaagc aaagcaaaga cgagcgcaac gatgccgatt tacaaaattc aaaaaataaa     1620
aaactcaatg aagaaattgg taaacgattg gctgaattgg gactgcctgc tacgaaacga     1680
tatattcaaa aatataaatt catttttcca tcgcttagca aaaatctaaa agatgctcgc     1740
gttaacaatc aatgtattta ttgtggagaa acatttaatt taacggaagc tttaagtggt     1800
gatgcttttg atgttgacca cattgtcccg aaagctttat tgtttgatga ttcacaaacc     1860
aataaagtat tggttcatag aaaatgtaat tcgacaaaaa ccaatcaaac tgcgtatgat     1920
tacattgcta caaaaggtga cgaacaagtt cgtatttatt ctgaacgaat tgatgattgg     1980
tttaaaagag gaattatttc ttacagtaaa atgcaaagat taaaggtttc acataaggaa     2040
tatcttgaaa gaaaaaaaat aggaaaagaa accgaaactg ataagaagct ttgggaaaat     2100
tttatagaca gacagttgag agatactcaa tatatttccc gaaaatcaag agagattcta     2160
cagaaagtat gcaacaatgt aactacaaca gaaggcggag ttacagcaaa acttcgcaat     2220
ttgtggggtt gggatgatgt tttgatgaat ttgcaaatgc caaaatataa agaattaggg     2280
caaactgtca tcaaagaatg gacaagcgac cacggaaaaa gaaaacatca aaaagaagaa     2340
atagaaaatt ggacaaaaag agatgaccat cgtcatcacg ccattgatgc tttggtaatt     2400
gcctgcacaa gacaaggttt tattcagcgg ataaatactt tgaattctag cgatactaaa     2460
gatttaatga tgaaagaagt tgaaaaagca aaaatcgaat ttaatgaaaa gagtaccctt     2520
ttagaaaaat atttaaagac tcaaaagccg tttactacag aacaagtaat gaaagaagct     2580
gataaaattt tagtttcatt taaagcaggt aaaaaagtag caacaataac taaatttaaa     2640
gctacaggaa aaaataaaga tacaggagta attgttccaa gaggagcgtt acatgaacaa     2700
aatgtttatg gtaagataaa agctattgaa aaagataagt ctttaaagta tttgtttgaa     2760
aattcaggga aaattgtaaa tcctaaaatt aaaaatttag ttgaaataag actttcggaa     2820
aatgaaaata gttcaaaaat ggctttatca acattaaaga aaaatcccat tttcctaaat     2880
gaagaaaaaa ctgatttact agaaaaggca tcatgttatg agtatgttac tgttagaaag     2940
tatcctttga acacaataaa agcaagtcag gctgatgata ttgttgatga aagagtgaaa     3000
tttttagtga aagaaagatt ggcccaattt ggaaataaag aaaaagaagc ttttaaagat     3060
acactttggt tcaacgaaga aaaacaaatt ccgattatta ccgttcgttt atttgctcgt     3120
cctgatgcta ataatttaca ggcaatgaaa aaggatgaaa acggtaaaga aataggattt     3180
gtagtgttgg gcaacaatca tcatatcgcc atttatgagg ataaagacaa caagcttgtg     3240
cagcacagtt gtactttttg gcatgcagtg gaaaggaaaa aatataacat tccaccagta     3300
attaaaaatt cctcagaaat ttggaatcaa ttattaaata aagaattccc agaaactttt     3360
ttggataaat tacctgcgga taatctcgaa ttaaaattta gtatgcaaca aaatgaaatg     3420
tttattctgg gattaccaca agaagaattt gaagaagcaa taaaaaataa tgataaatct     3480
gttttgagta aacacatgta tttagtttgg agtattgctg acggagatta ttggtttaga     3540
catcatttag aaacaaaaaa tacagagtta aagaaaatca atggtgcaaa agaaagcaaa     3600
agatttttca gattgcaaag tcttaaggct gtagaaaatt tgacaccaat caaggtaaga     3660
ctgaatcatt taggagaaat aactaaaata ggagaatact aa                        3702

<210>  40
<211>  3807
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Cas endonuclease of Locus 22

<400>  40
atgatgatta aaaatatact tggattagac ttaggaacca actcaattgg ttgggcatta       60
atagaagttg atgaaaataa tattcctatc cgaattgttg caatggggtc tagaataatt      120
cccttgtcaa caagtgataa agaggagttt caaagaggtt tatcaattac aaagaatcaa      180
agtagaacgg taagtcgtac ccagagaaaa ggttataata ggaaacaatt aaagaaaaat      240
gatctaaaga aaattctaaa taaatacaat atttttccat cagaagaatt gttaaaactt      300
ccaatgcttg atttgtggaa attaagaagt gactctgcta atcccaatga aaatatttct      360
gcagaacaat taggacgtat tctttatatg cttaatcaga aaagaggtta taaatctgct      420
agaagtgagg ctaatgctga taaaaaagat acagactatg ttcaggaggt aaaaggccgt      480
tatgctcagt tgaaagagag agagcagact attgggcagt atttttatga agggctttct      540
accgcttttt cagacaaaga taatcggcag tattttagaa tcaaagaaga agtttatcca      600
agagaagctt acgtagaaga gtttgatact atcattaatg ctcaaaaaga taagcatgat      660
tttcttacag ataaagtagt tcatcaatta agaaatgaaa tcatttattt tcaaaggaag      720
ctgaaatctc agaaaggatt agttagtatc tgtgaatttg aaggttttga gaaaactgtt      780
tttgataagg aaaaaaacaa aaataaagtg gtgtttattg ggccgaaagt agctcctaaa      840
acgtctccat tgtttcagct ttgccggatt tgggaagtcg tcaatacgat tactttaaaa      900
ataaaaaatc cagaaggaag taaatataaa tggggtgaaa aaattccgga tttaaaggag      960
aaagaaattt tagcagatta tttatttaaa aacgaaagtg taagttttag taaacttctc     1020
gaaattttag gattaaaaaa agaaaatgta tatgtgaata agcaaatcct gaaaggtatt     1080
aaaggaaacg aaacatatgc agctctttat aatgttttag gcgataatga acttttgaat     1140
tttaatgtat ctatcattac ttcaaatcat actgcgatat tgatagataa gaaaacaggc     1200
gaaattcttg aagaaagagc tggccttgaa cttgatgcat ttttggaaaa agagccgtta     1260
tatcaactgt ggcataccat ttattccctg aaagacttag atgaatgtaa aaatgcgtta     1320
attaaaaggt ttggtttcga agaagacatt gccgaaaaat tatcttgtat cgattttaat     1380
aaacaggctt tcggtaataa atcgaataaa tcgatgagaa aaattcttcc ttttctgatg     1440
gagggctatg attattctca atcctgcagc ttggcgggct ataatcattc taattcttta     1500
actaaagatg aaagagaaca acaaattact ttagaccgat tagaacttct ttccaaaaat     1560
agtttgagac aacctattgt tgagaaaatt ctgaaccaga tgattaatgt agttaatgca     1620
attcttgagc aatatggaaa accatctgaa attagagttg aacttgcccg tcaacttaaa     1680
caaagtaagg acgagcgaaa tgaaactgat ttgcaaaact ctaaaaataa aaagctcaat     1740
gaggaaattg gaaaacgatt agcggaattg ggactgcctg taaccaagcg ttatattcaa     1800
aaatataaat tcatttttcc atcacttagt aaaaacctga aagatgctca cgtcaataat     1860
caatgtattt attgtggaga aaccttcaat ttaacagaag ctttgagtgg ggatgcttat     1920
gatgttgacc atattgtacc gaaaacttta ttatttgatg actcacaaac caacaaagtt     1980
ttggttcatc gaaaatgtaa ctcgacaaaa actaatcaaa ctgcgtatga ttacattgct     2040
acaaaaggag atgaacaggt tagggtatac tcagaacggg tggatgactg gttcaagaga     2100
ggaattatct cttacagtaa aatgcaaagg ttgaaagttt cacacaaaga atatcttgaa     2160
agaaaaaaac ttggaaaaga aacagagacg gataagaagc tttgggaaaa cttcatcgac     2220
aggcagttga gagatactca atatatttct cgcaaatcaa gggaaatttt gcagaaagtg     2280
tgcaataatg taacaacaac agaaggtgga gtgactgcaa aactgcgtaa tgtatggggt     2340
tgggatgatg ttttaatgaa tcttcaactg cctaaatata aagaattagg gcaaactttc     2400
accaaagaat ggacaagcaa acatggaaaa agaaaacacc aaaaagaaga aatcgaaaac     2460
tggacaaaaa gagatgatca tcgccatcac gccattgatg ctttgataat agcttgtaca     2520
aaacaaggct ttattcaacg aataaatact ttgaattcga gtgagacaaa agatttgatg     2580
gtaaaagaag ttgagggagc taaaatagaa tttaatgaaa aggctacgct tttagaaaaa     2640
tacttaaaaa ctcagaaacc ttttgataca catgaagtaa tgaaagaagc tgataagatt     2700
ttaatttcat ttaaagcagg aaaaaaggta gcaacaataa ctaaatttaa agcaacagga     2760
aaaaataaag agacgggggt aattgttccg agaggagctt tacacgaaca atctgtttat     2820
ggtaaaataa aagtaattga gaatgataaa cctttaaaat acttgtttga aaactcagat     2880
aaaattgtaa atccaaaaat taagaatctt gttgaaacaa ggctcacaga aaatgaaaat     2940
aattttaaaa aggctttatc aacattaaag aaaaatccaa tctttttcaa tgaagaaaaa     3000
accgagatat tagaaaaagc atcttgctac aatgatgcca ctgttttgaa atataagtta     3060
caaaatataa aagcaagtca ggccgatgat attgttgatg aaagagtgaa atctttagta     3120
aaagaaagac ttgctcaatt tggaaataaa gaaaaagaag ctttcaagga tattctttgg     3180
cttaatgaag aaaaacaaat tccgattata acggttcgtt tgtttgcccg tccagatgca     3240
gataatttac aggctattaa aaaagataaa tatgggaatg agataggatt cgttgtgacg     3300
ggaaataatc atcatatcgc aatttatgaa gataaagaca ataagcttgt tcagcatact     3360
tgtacatttt ggcacgcaat agaaagaaaa aaatacaata ttcctgctgt tattggaaat     3420
tcatcagata tttggaacca attattagac aaagaacttc caatatcatt tttgaataaa     3480
ttaccgatgg ataagctcaa tttaaaattt agtgtgcagc aaaatgaaat gtttattctg     3540
gggttatcac aagacgaatt tgatgagaca attaaaaata atgataaatc tttattgagt     3600
aaatatttgt atttggtttg gagtattgca gaaggtgatt attggtttag acaccatctg     3660
gaaacaaaga acactgagtt aaagaaaact gatggagcaa aggaaagtaa aagatattat     3720
cgattaagtt caaaaggttt tattgactta aatccaataa aagtcagact gaatcattta     3780
ggagaaatta ccaaaatagg agaataa                                         3807

<210>  41
<211>  3795
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Cas endonuclease of Locus 23

<400>  41
atgaaaaaaa tattaggatt ggacttgggg acaaatagta ttggatgggc tttgattgaa       60
attgataaaa ataatattcc tattagcatt attgcaatgg gttctcgaat aataccttta      120
tcatctagtg ataaagaaga gtttcaaaga ggtttgtcaa taacaaagaa tcagagtaga      180
acggttagcc gcactcaaag aaaaggatat gaccggaaac aattaaaaaa aagtgatcta      240
aagaaaattc taaataaata caacattttt ccttcagaag aattattaaa acttccaatg      300
cttgatttgt ggaaattaag gagtgattct gctaatccaa atgaagatat ttctgccgaa      360
caactaggcc gtatattgta tatgctaaat cagaaaagag gctataaatc tgctagaagt      420
gaagcgaatg ctgataaaaa agataccgat tatgtacaag ctgtaaaagg acgttatgct      480
catttgaagg ataggactca gactattggc caatacttct ttgaagaatt agacaatgca      540
aatactaata attcttattt tagaataaaa gaagaagttt atcccaggga agcttataca      600
gaagaatttg acgccataat taatgctcaa aaaggtaaac acgactttct taccgatgaa      660
gttgttcatc aattaaggaa tgaaatcatt tattttcaaa gaaaactgaa atctcaaaaa      720
ggattagtga gtatttgtga atttgaaggt tttgagaaaa ctattttcga taaggaaaaa      780
gacaaaaata aagtggtact tgttggtcca aaagttgctc caaaaacctc tcctctattt      840
caactttgcc gtatttggga ggttgtcaat acaattacat taaaaataaa aaatccagaa      900
ggaagcaaat acaaatgggg tgaaaaaatt ccaaatttaa aagagaaaga aattttagca      960
gattatttgt ttaaaaatga aagcttaagt tttagtaagc ttcttgaaat tttagaatta     1020
aaaaaagaaa atgtttatgt gaataagcaa atccttaaag gtcttaaagg aaacgaaact     1080
tattctacta tccatagtat tttaggagat aatgaacttt taaattttga tgtgtctatc     1140
attacttcaa atcatacatc aatgttggta gacaaaaaga cgggagaaat tttagaagaa     1200
agagcgggtc ttgaacttga tgcatcatta gagagagaac ccctatatca attgtggcat     1260
acaatctatt cattgaaaga tttagatgaa tgtaaaaatg ccttaatcaa aagatttggt     1320
tttgatgatg aaattgctaa aaaattatct cgtattgatt ttaataaaca ggctttcgga     1380
aataaatcga ataaatcgat gaggaaaatt ctaccttttc tgatggaagg ctacgattat     1440
tctcagtctt gcagtttggc tggttataat cattctaatt ctttaacgaa ggatgaacga     1500
gaacaactaa tcactttaga ccagttagca ctccttccta agaacagtct cagacaacca     1560
attgttgaga aaattctgaa tcagatgatt aatgttgtta acgcaattct tgaacaatat     1620
ggcaaaccct ctgaaattag agttgaactc gcacgtgaac ttaaacaaag taaggacgag     1680
cgaaacgata cagatttaca aaattcaaaa aataaaaaac tcaatgagga aatcagaaaa     1740
cgattggttg aactgggatt acctgtaact aaacgatata ttcaaaaata taaatttatt     1800
tttccttctc ttagtaaaaa tctgaaagat gctcacgtta acaatcaatg tatttattgt     1860
ggagaaacat ttaacttaac ggaagctttg agtggtgatg cctacgatgt tgaccatatt     1920
gtgccgaaag ctctattatt tgatgattct cagaccaata aagttttagt tcacagaaaa     1980
tgtaattcaa caaaagacaa attaacagca tacgattata tttctacaaa aggaatagag     2040
caagttagag tatattctga acgtgtggat gattggttca aaagaggtat tatttcttat     2100
agtaaaatgc aaaggttgaa agtttcacac gaagaatatc tggaaagaaa aaagatagga     2160
aaagaaacag agactgataa aaaactttgg gaaaacttca tcgagagaca attgagagat     2220
actcagtata tatctcgtaa agcaagagaa attttacata aattatgcaa caatgtgact     2280
acaacagaag gcggagttac agcaaaactt cgtaatttat ggggttggga tgatgtttta     2340
atgaatctac aaatgcctaa atacaaagaa ttaggacaaa ccgtcatcaa agaatgggca     2400
agcgatcatg gaaaacgaaa acaccaaaaa gaagaagtcg aaaactggac aaaaagggat     2460
gaccaccgcc atcacgccat tgatgctttg gtaattgctt gtacaaaaca aggttatatt     2520
cagcggataa atactttgaa ttcaagtgat accagagatt tgatgataaa agaagtggaa     2580
gaagcgaaaa tagaatttaa tgaaaagtca acacttttag aaaaatattt aaaaactcaa     2640
gagccgttta ctactcaaga agtgatgaaa gaggctgata agattttaat ttcttttaaa     2700
gctggcaaaa aagtagcaac aataactaaa tataaagcta caggcaaaaa caaaaatact     2760
ggtgttcttg tcccaagagg agctttgcac gaacaaaacg tttatggcaa aataaaagtg     2820
attgaaaagg ataaatcttt aaaataccta ttcgaaaatt cagataaaat agtaaactct     2880
agtattaaaa aacttataga agtaaggctt ttggataatg aaaataattc taaattggct     2940
ttatcctctt taaagaaaaa cccgattttt ctaaatgaag aaaaaaaaga agtattagaa     3000
aaagcgtctt gttatgagta tgtcactgtt aaaaaatatc ccttgaacac aataaaagcc     3060
aaccaagctg atgatattgt tgatgaaaga gtgaagtttt tagtaaaaga aagattatct     3120
caatttggaa ataaagaaaa agaagctttt aaagatacgc tttggtttaa tgaagaaaaa     3180
caaattccta ttattactgt tcgtttattt gctcgtccag atgcaaataa tttgcaggca     3240
ataaaaaaag ataagaacgg taaagaaata ggatttgtag tgacgggaaa caatcatcat     3300
attgcaattt atgaagacaa agacaataaa cttattcagc acagttgtac attttggcat     3360
gcagtagaaa gaaaaaaata caatgttcca accgttatta aaaattcatc tgatgtttgg     3420
aatcaattat tacacaaaga attaccagaa tcatttttaa ataaattacc tgctgattat     3480
ctcaatttaa aattcagtat gcaacaaaat gaaatgttta ttctgggctt atcacaagaa     3540
gaatttgatc aagcaattaa aaagaataat aagcccttat tgagtaaaca tttgtattta     3600
gtctggagta tcacagatgg agattacttt tttagacatc atttagaaac taaaaataca     3660
gaattgaaga aaacagacgg agcaaaggag ggtaaaagat attttcgatt aagtacaaaa     3720
gggcttacag atttaaatcc gataaaagtt agattaaatc atttaggaga aataactaaa     3780
ataggagaat attag                                                      3795

<210>  42
<211>  4395
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Cas endonuclease of Locus 24

<400>  42
atggcgaaaa ttttaggatt ggatttaggg acaaactcga ttgggtgggc gattgttgat       60
aaagatggaa atgatttttc ccttgtagat aagggagtga gaatattttc cgagggagta      120
aaatctgaaa aaggaattga aagttctcgt gctgcggaac gaactggtta tagaagcgca      180
agaaaaatta aataccgcag aaaattaaga aagtacgaaa ccttaaaagt tctttcctca      240
aatggaatgt gtcctttgtc ggttgaagaa gttgaagact ggaaaaaatc cgggtttaaa      300
aaatatcctc ttaatcctga atttttgaaa tggttacgaa cggatgaata ccaacatata      360
aacccatact attttagaga tagagcaagc aagcaaaaag ttgccttatt tgaattggga      420
cgtgctttat atcatattgc tcaaagaaga ggttttttga gtaatcgtct agatcagtca      480
gctgaaggag tttttgaaga acataatcct caaatccaaa gtttgattga agatttggat      540
gattcgaaat taattcttga tgaattgaaa aattattatg ttgataaagg aataattgaa      600
gaagctgaaa aaggagtttt taaaaaagat ttagatgaag gtgagaaaaa actaaaatca      660
ctttataatt cgttagtagg aataattaag aagaatgaaa acaacgttga aaaatgcaaa      720
gaggaattta ttgcaaggct taataaaaaa gaagatttag gaaaagtaaa aggaaaaatc      780
aaagatattt cgcaagcaat gcttgatggt aattttaaaa ctttaggaca atattttttc      840
agtctttaca ataaaggaaa aataagaaat caatatactt cgagagaaga acattatttg      900
gaagagttta ttactatttg taaaattcag ggaatcgaag gaattgatga taaagaaaaa      960
ttacctgaaa agaagtttac aggcttagcc aaagatttgt acaaagccat tttctttcag     1020
cgtcccttaa aatctcaaaa aggactgatt ggaaagtgtt cctttgagaa aagcaaatca     1080
cgttgtgccg tttcgcatcc cgattttgag gagtacagaa tgtggactta cttaaacact     1140
atcaaaattg gaacacaaag cgaaaaaaca ttacgttttt taacgcaaga tgaaaaatta     1200
aaattagttc caaaattcta cagaaaaaat gattttaatt ttgaagtttt agccaaagaa     1260
cttgttgaaa aaggagcaag tttcgggttt tataaatctt ccaaaaagaa cgattttttt     1320
tattggttta attacaaacc aactgattcg gttgcagctt gtcaagtttc agcatcttta     1380
aaaaatgtga ttggtgaaga ctggaaaaca aaaatattta cttataaaac tttaaatgca     1440
aaagaagaag aagtaacaaa atctgttgat tataaagact tatggcactt actttccgta     1500
gcaacatcgg atatttattt ggaggaatat gctaaagata aattagggtt tgacgacaaa     1560
aatgccaaag ctttcagtaa aataaaactc aaaaaagatt tcgctagttt gagttcatca     1620
gcgatcacga aaattttgcc ttatgtaaaa gaaggacttt tgtattctca cgctgttttt     1680
atggcaaata ttgaaaatat tgttgatgaa aatatttgga ataatcttga ccaaagaaat     1740
tatattcagt ctaaaatagc cgaaattatt gagggctata cttttgaaaa aacaggtttg     1800
gaagtagtca acagccttat taaagaatat aaaacagaaa atgattacag caaaaaagta     1860
tattattcaa aagaagctga accagaattt gaaaaagatt taaagcaaaa attagtagtt     1920
ttttataaat caaatgacat tgaagatgaa aatataaaac aagctatttt taatgattta     1980
tattcagttt taattgacca acttaaaaaa tatgagtata tcaaaataca acgattggat     2040
gagaaagttt tagagttttt aaaaggtgaa aatgaagacg gagaagtttt ttgcaataat     2100
ccaaagcaat taaaaaagct gtatcatcca tcagatattg aaatttttaa aaagcaaaag     2160
gtcaaagata aagatggtaa agaaacggga cagcttattt taggtagccc tttaacttct     2220
tcaatcaaaa atccgatggc aatgcgtgct ttgcatcaat tgcgtaaagt tttaaatact     2280
ttgattttgg aaggtcaggt agatgaaagt acaaggattc atattgaaat ggctcgtgag     2340
ttaaacgatg ccaaccgaag aaaaggaatt caggattatc aaaaagagaa taaagatttc     2400
agagacaatg ctattaaaga aatcaaaaaa ctgtatttgg acgaatgtgg taaagaagta     2460
gaaccaacgg aagatgatat tttaagatat cagctttgga ttgaacagga caaatgtgag     2520
atttacgaac aaggcaagaa tattagtatt tgtgatataa taggaagtaa tccagcttat     2580
gatatagaac atacaattcc aagaagtatt tcgcaagata attctcaaat gaataaaacg     2640
ctatgcagtc agcgatttaa cagggatgtc aaaaagcaaa aaatgccaat tgaattgagc     2700
aatcatttgg aaattttgcc aagaattgcg cattggaaag aagaagccga caacttatca     2760
agggaaattg agataattag ccgttccata aaagccgcat cgaccaaaga aattaaagat     2820
aaaaaaatac gaagaagaca ttatctgact ttaaaacgtg attatcttca agggaaatac     2880
gatcgattta tttggaaaga gccaaaggtt gggttcaaaa acagtcaaat tccggataca     2940
ggaattatca ccaaatatgc gcaagcttat ttaaaatcgt attttaaaag agtagaaagt     3000
gtaaaaggcg gaatggttgc cgagttcaga aaacaatggg gaattcagga gagttttatt     3060
gacgaaaacg gatttaaaca atacaaagaa aaagatagaa gtaaacacac ccatcatacc     3120
attgatgcca ttactattgc ttgtatgacc aaagacaaat atgatgtttt ggctaaagcc     3180
tggacttctg aagatgaaca agataaacta aaggcaaaag ctctaatggc agatgccaag     3240
ccgtggaaaa cctttaaaga agatttactc aaaatagaag atgaaatttt agtttcacat     3300
tacacgcccg ataatgtaaa aaaacaatct aaaaagatta ttagggttcg tggcaaaaaa     3360
caatttattg cagaaattga gagagatgtc aaaggtaaag caatacaaaa aaaagatgct     3420
aatggaaaag tagtttacaa gttaaatgat aaaggagaaa agatcccaag attgcagcaa     3480
ggtgatacta ttcgaggctc gttacaccaa gatagtattt atggagcaat taaaaatcca     3540
ttaaatactg atgaaatacg ttatgtgatt cgtaaagatt tagaaagtct gaaagcaagt     3600
gatatcgaaa acattgtgga tgaaactgta aaagagaaag taaaacaagc cgttacaaat     3660
aaagttttgt tgctttcttc caatgcccaa caaaaaaata aaattgccga gaatgaaaag     3720
gtttggatga ataaagaaaa acaaatttcc attaacaaag ttagaattta tgccaattca     3780
gttaaaaacc cactggaaat aaaagagcat agtttattgt caaaatctcg tcacgaacac     3840
aagcaaagag tatatggtca gaatgatgag aattatgcaa tggcacttta tgagttagat     3900
gggaaaagag aatttgaatt gattaataat tttaatttgg ctaaactcat aaagaatgga     3960
caaggatttt atcctttaaa taaagaaaaa gaattaaaag gtaaaaaagt tttatatccg     4020
attgcaaaaa gtaacagcag agatgttgtt ttgaaacgag gacaacaagt tgtttttttt     4080
gataaagaag ttgaaaagcc aaaggatatt tctgaaatct tggattttaa aagaagggtt     4140
tatataattg aaggtttgtc cattcaaaga ataaaatcgg ggaataatga atttgaatat     4200
ggtgtaatta tgttaagata tttcaaagaa gcaaggaaat cagatgaaat caaaaaagat     4260
aattttaaac cagatggtgt ttttaaatta ggagaaaata aaccaacaag aaaaatgaat     4320
cacagccaat ttaccgcttt tgttgaaggt attgatttta aagttttacc atcaggaaag     4380
tttgtcaaaa tttga                                                      4395

<210>  43
<211>  4377
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Cas endonuclease of Locus 25

<400>  43
atggcaaaga ttttaggatt agatttaggg acgaactcga ttggttgggc gattgtagat       60
aaagacgaaa ataatttttc attagtagat aaaggagtca gaatattttc tgaaggagtt      120
aaatctgaaa aaggaattga aagttctcgt gctgctgaac gaacaggatt tagaagtgca      180
aggaaaatta aatatcgaag aaagctaagg aaatacgaaa ctttaaaagt tctgtcatca      240
aatggaatgt gtccactttc aattgaagaa gtggaagact ggaaaaaatc aggttttaaa      300
caatatccac ttaatcccga attcctgaaa tggttaagaa ctgatgaggc tgaaaacatc      360
aatccttatt tttttagaga taaagccagc aaacaaaaag ttcctttgtt tgaattagga      420
cgagcattct atcatattgc tcagagaaga ggttttttga gtaatcgttt agatcaatct      480
gcagaaggaa ttttagagga acattgccct aaaattgaaa caattgtaga agatttgaat      540
tcttatgaag aagttttaga aaatttaaaa gattactttt tttttgaaac tggaattctt      600
gatgctaatg aaaaaagtgg ttatgcaaaa gatttagatg aaggtgataa aaaattggtt      660
tctttataca aatcacttca taccattgta aaaaagaatg atactaattt tgaaaaaggt      720
aaagcagaaa ttattgaacg actcaacaaa aaagatgttt taggaaaagt aaaaggaaaa      780
attaaagata tttctcaagc tatggtcgac ggaagtttta agactttagg gcaatacttt      840
ttcagtttat atagcaaaga aaaaattaga aatcaatata cttcaagaga agaacattat      900
ctcgaagaat tcataactat ttgtaaagtc caaggaatcg attccattaa cgagaaagaa      960
caattgccag agaagaaatc cgatggttta gccaaagatt tatacaaagc catattcttt     1020
caaagaccat taaaatctca aaaaggattg attggtaaat gttcttttga aaagagtaaa     1080
tcccgctgtt ccgtttcgca tcctgatttt gaagaataca gaatgtggaa ttacattaat     1140
acaattaaaa ttggaacaca aagcgaaaaa acattgcgat ttcttacgca agaagaaaag     1200
ttaaaattag ttccaaaatt ctacagaaaa aacgatttta attttgaagt tttagccaaa     1260
gaattaattg aaaaagggac gagctttgga ttttataaat cttctaaaaa gaacgattat     1320
ttttattggt tcaattttaa accaaccgat tcggtttctg cttgtcaggt ttctgcatca     1380
ttaaaaaata ttattggaga agattggaaa acaaaaacat tcacttacca aactttaaat     1440
gttaaaaaag aagaagttac aaaaacagtt gattataaag atttatggca cttactttca     1500
gtagcgactt ctgatattta tttgaataaa tatgcaaaag ataaattagg ttttgaggat     1560
aaaaacgcaa aagcattcag taaaatcaag ttaaaaaaag attttggaaa tttaagtttg     1620
tcggcaatta ctaaaattct gccttacata aaagaaggat tgctctattc tcacgctgtt     1680
tttatggcaa atatagaaaa cattgttgat gaggaaattt ggaaagatga acatcaaaga     1740
aaatatattc aaacccaaat agcagaaatt gttgaaaatt atacttttga gaaaagtcaa     1800
ttagaggtaa ttaatggact tataaaagat agtaaactaa aagaagaata ttattctaaa     1860
gaagcagaat caatttataa aaaagattta gctactaaat tagttttgtt ttttaaatac     1920
aatgttattg aaaatgaatc agaccaaaaa atcatttttg aaaacttatt tccaattttt     1980
attgagcaat taaaaaaata tgagttcatc aaaatccaga gattagatga aaaagtttta     2040
gaatttctta aaggagaaaa tcaagatggt gaaatatttt gcagcaatcc aaaacaatta     2100
aaaaaactct atcatccatc ggatattgaa gtttttaaaa agaaaatcat taaagacgaa     2160
tttgggaatg aaaaagtagt tttaggtact cctttaacat ctgctattaa aaacccaatg     2220
gcaatgaggg ctttgcatca attacgtaaa gttttaaata ctttgatttt agaaggtcta     2280
gtagatgaaa atacactaat tcatattgaa atggctcgcg aattaaacga tgctaacaaa     2340
cgaaaaggaa ttcaggatta tcaaaacgaa aacaaaaagt tcagagaaga tgcaataaaa     2400
gaaatcaaaa aactttattt ggatgaatgc aaaaaagaag tagaacccac agaagatgat     2460
attttaagat accaattgtg gattgaacaa aacagacaag agatttacga acaaggaaaa     2520
aatattagta tttgtgatat aattggaagt aaccctgctt atgatattga acatacaatt     2580
ccaagaagcc gctctcaaga caattctcag atgaataaaa ccttgtgtag tcaacgattt     2640
aatagagaaa ttaaaggaaa taaaatgcca attgaattga ataatcattt ggaaatcttg     2700
ccaagaattg cgcattggaa agaagaagcc agtaatttat caagagaaat tgaaattata     2760
agtcgttcca taaaagccgc tgcaaccaaa gaagtaaaag ataaaaaaat aagaaggaga     2820
cattatctaa cattaaagcg agattatctt caaggaaaat atgaccgatt tattttggaa     2880
gaaccaagag ttggatttaa aaacagtcaa attcctgata cgggaattat tactaaatat     2940
tctcaggctt acttaaaatc gtattttaaa agagtcgaaa gcgtaaaagg cggcatggtt     3000
gccgaattta gaaagcagtg gggaattcaa gaaagtttta ttgacgaaaa tggatttaag     3060
cattataaaa taaaagacag aagcaagcat acacatcaca caattgatgc cataacaatt     3120
gcttgtatga ccaaagataa atatgacgtt ttggctcacg cttgggcatt agaagatgaa     3180
caaaataaaa aagaagccaa agctattata gaaaaagcta aaccttggaa aacctttaaa     3240
gaagatttgt taaaaatcga agaagaaatt ttagtctcac attatacacc cgacaatgta     3300
aaaaaacaat ctaagaaagt tattagaatt cggggtaaaa aacaacacgt tgccgaaatt     3360
gaaagagatg aaaaaggaaa ggcaattcct aaaaaagatg ctaacggtaa aattctttac     3420
aagttagata aagaaggaaa aaaacttcca agatatcaac aaggcgatgc cattagaggt     3480
tctttgcatc aggatagtat ttatggagca attaaaaacc ctttaaatac ggaagaaatt     3540
cgttatgtta ttcgtaaaga tttagaaagt ttaaaagcat ctgatattga aaatattgtt     3600
gatgaaactg taaaagaaaa aattaaagaa gcagttgcaa ataaagtctt gttattttct     3660
tcaaatgccc aacaaaagaa taaaattaga gagaatgaaa aggtttggat gaacgaagaa     3720
aagcaagttc caataaacaa agttagaatt tatgctaatt ctgtaaaaaa tcctttggag     3780
gtaaaagaac atagtttatt gtcgaaatca cgtcatgagc ataaacaaaa ggtatatggg     3840
caaaatgatg agaattattg tatggcaatt tatgaattag aaggcaaaag ggaatttgaa     3900
ttaattaata attttaattt agcaaagttg attaagggag gacaaggatt ttatcctttt     3960
tataaagaaa aggaggtaaa aggaaaagta gttcaagttc ctattgctaa aaggaatggt     4020
agagatttaa ttttaaaaag agggcaacaa gtaatttttt atgataaaga tgttgaaaat     4080
cccgatgatg tttttgattt agtggattta aaaggaagaa tttatattat tgaaggattg     4140
tcgattcaac gccaagttgt ttctggaaag ctttatgagt ttggtagtat tatgtttcgt     4200
tattttaagg aagccagaaa agcagatgag attaaaaaag atagttttaa acccgatggt     4260
acttttaaat caggagaaat aaaaccgact cgtaaaatga atcataatca atttaccgct     4320
tttgtagaag gaattgattt taaagttttg ccatcaggta agtttattaa aatttaa        4377

<210>  44
<211>  3384
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Cas endonuclease of Locus 26

<400>  44
atggcaaaga ttttaggatt agatttagga actaactcga taggttgggc attaattgac       60
gataaattaa ataaaatttt agggattgga agtagaattt ttccaatggg ggttgaaaat      120
cttggtgatg gcgataacga aatgtctaag aatgcaagtc gaacaggagc aagaggagtt      180
cgacgtcagt tttttagacg aagactaaga aagaaagtgt tactaaaatc actttctgaa      240
aataatatgt gtccaataaa caccaaagat tttgaagatt ggaaacaaac taaacagttc      300
cctaatgaaa aattagcaac ttggtttgct atgaatcctt atgaattgcg tcaaaaagca      360
ttgacggaaa aattatcttt agaagaaata ggtagaattt tttatcatct aattcaaaga      420
agaggatttt taagtaatag tagaaaagga ggaagcgatg atggagctat ttttaaagga      480
aatgctaaag aaggaaaaat aggaattgat tatactttag aaagtatcga aggaaaaaca      540
ttgggttcat atttatatga gatttatcca aaagaaaatc agccttttca atatggacta      600
gaaagaatca gaaacagata tacaactcgt agaatgtata ttgacgaatt tgaaatgatt      660
tggaataaac agtcagaatt tcattcggtt ttgaattatg atttaaaaac aattttaggg      720
ggtagaaaac aagataatta cacagaagac ggtattttat tttatcaaag acctttgcgt      780
tctcaaaaac atttagttgg aaactgttct tttgagcctt taaaaactaa atgccctata      840
agtgctattc ctgtagaaat gtttagaatt tggcaatggg ttaatacagt tgaatataat      900
gggaagaaaa tatctgaaga agaaaaaacc aaactagttg agcaattgct ttcattcgat      960
aaaattgaat ttaaaaaact ccgaaaagct attgggaaag aaagtgcgga gtttaagttt     1020
aattacaaag acgatgataa aattgctggt acacatacta tctctaattt atccaataga     1080
aaattctttg gcaaaagatg gtttgatttt tcagataaag agcaagaaga tatttggcat     1140
gttctgtatt tttttgatag caaatcaaac ctaaaagaat atgctgttaa gaattggaat     1200
tttagtgaag aacaagcaat tgcaatttca aggtttaatg taaaagacgg ctatgctagt     1260
ttgagtcgaa aagctattgg aaatattttg ccttttttgc agcaagggta tacttatgat     1320
attgcagttg ttatgggcgg aattaaaaat gcttttggtg acaaatggca aaatgacaca     1380
gtagaaaata agctaaaaca actagatttg attgataata ttgaaggtat agttaggtct     1440
aaaatttcag gaggatttat agatacaatt aaggatttat tacgtaaaga atttgaattt     1500
aatgacaaac aattaaaaaa actttaccat cattctgctg caattgatac ggtagcatta     1560
ttacgaaaac tgccaactgg gaaacaggca gataaggata ttcaagctat tagaaatcca     1620
attgtaatta cagctttatt cgaattacga aaattggtca atgaattaat cgaagagcat     1680
gggcagcttg acgaaataaa agtagaaatg gcccgtgacc tgaaaatatc aaaatcgcag     1740
cgaaataaga tacgcaaaga tcaaaaacga ttggagagag aaaatgacag agtaaaaaag     1800
gaagtagaaa agtatgtaag agtttctcat gataacattc taagatttaa gctttgggag     1860
gaatgcaagc agacttgtcc ttatacaggt gttgtaattc cagtcacaaa actttttaca     1920
ggggaaatac aaatagagca tatccatcct tggagtcgtt cgttaaacga tagtttcaat     1980
aataaaacat tgtgctatgc ggatgaaaat agacgaaaag gagacaaaac accttttgaa     2040
ttttatggaa gcgatgagct ggattggatt gctagaaaag aacgtgcttt aaaattgttt     2100
tctgatacta aagagtatcc caatgcctat caaaaattca agcgatttgt acagcaaaaa     2160
tttgacgatg atttttcttc aagacaatta aatgatacac gatttataag taaagaagca     2220
tcgtcttatt taaaacaaat atgtgaaaag gtaaatgttt ctccaggtca aatgacagct     2280
aacttacgtc aaaaatgggg tttgaatacg gttttgaatg atgaaaatgc taaaactcgg     2340
gaagaccatc gtcatcatgc tattgatgct ttggttatgg catgtgggaa gacaagttat     2400
ttacaggaat tgtcaaaatg gaatcgttac aatagaaatt atgatttaaa agattttcct     2460
atgccttggg aaactttccg atttgatgct gagaaagcaa ttgataaaat attgatttcg     2520
cataaacgta tttctaatga tattacaact cgatatacta aagtggaaaa aaacggaaag     2580
acatatataa ataagggagt tgcagcacga gggcaattgc ataaggaaac tgtttttggt     2640
aaacgaaatt ttaatggaga tgaagcattt catgttagga aatcaattga tagtttaaca     2700
actgagaaac aattagaaaa agtggttgat gaagttatta aaaaattaat tcataagaag     2760
attaaggaat tgggaggatt cgtaaaaggt actatccctg ctaatacttt tttcaatgtt     2820
gatgaaaatg gagttaaaca accacaaatt ttcctgccaa ataaaaatgg tagtccagtt     2880
ccaattttaa aagtccgaat gaaagaaaat attagtggag ctgaaaaatt aaaagacaat     2940
gtcaatcaat gggtaaaccc tagaaataat catcacgtac ttatttataa ggatgaaaaa     3000
ggaattttaa gggaagaagt ggtgactttc tggactgttg ttgaaagaaa aagtaaagga     3060
tttccagtgt atcaattacc agttgaagga aaagagatag tgacagcttt gcatattaat     3120
gatatgtttt tgttaggatt aaatgaagaa gaaatcaatt gggagaatcc agattatgag     3180
attctaagag atagtttata tagagttcaa agtttgtctt caaaatatta tgagtttagg     3240
cagtctatta atgcagaatc tcaaaataaa atttcaccta tttatgaaca aattagagga     3300
tttggttcgg gtaaaaccgg ttgggattct tttaatccaa taaaagtaaa aatttcagtt     3360
tcaggaaaaa tttcaaaaat ataa                                            3384

<210>  45
<211>  3327
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Cas endonuclease of Locus 27

<400>  45
atggcataca aattaggaat agatctgggc accgcgtcca ttggtgctgt cgccatccgc       60
atcgaaaaca acgaaccaca aagcattgac tggcatgcag tacgcattta cagcgaacca      120
gttgtaaaca ctccgaaagg gctgcaaccc aaaaaggcgg cccgccgtga cgcacggcaa      180
ttgcgcaaac agattgaaag gcgagcacga cggttgcgcc gcattgccaa tctgattcca      240
ttgctgggat tgcataaagc cgaagtgaaa ccggggcgcc gtcaggattt gaccacattg      300
cgcgccatcg cagcgcgcca gcaggtcgag ctaaacgagt ttgccctagt actgctgcgt      360
ctggccaaac gccgtggtta cgccggtgga tttcgcgatt ccaaagacgg tgtagtcaag      420
agctccagcg acaaactgag cgaggaaatg agacgtcttg ccgagacgca aaacctgcag      480
gaaataactc tgggtgaata cctgctgtac agacaggaac acggactgcc tgtctggctc      540
aaagccgaac gtccaggtct ggaaccgcgc tatgccctgc gcgaaatggt aaccgccgag      600
ttcgaacagc tctggacaac ccaggcccga taccacccga tcctggcctc taatcatctc      660
ggcaagccac ttaagcaatg gttcaatgaa gcgctgttct accagcggcc actgaagtct      720
cccgcccaca tggtcggcaa ttgcctgctt gagcccaatc tgccacgtgc cccacgcgct      780
cacatggcag cccaacactt cagaatcgat aaaacgctcc atgacatgcg ctggggtagt      840
gggcgacggg ctgaacgcct gagcaaggca caactcaacg tgctgcgtca gatgctgaat      900
gatccagcca atgccgatgg caaggtcagc ttcaaacacc tgtatcaagc tttgagcgag      960
acagggttga gcgatccacg aagtcgcact ttgaatctgg agcgcagcag ctgtgatcaa     1020
ctgtccggta acaacacggt tgctcgttgg cgtgcgttgg gactgtacga ccaatggctg     1080
acgctagccc ctcgcgacca gacaaccatc atcaacttgc tggcggactt gggcgggccg     1140
gaactgctgg ttccggacga ctggcaccag aacatccgca agagcagcgc caaagctggc     1200
gataccaacc tttatcgtcg attccggccc gaggtcgttg atttcatcaa tgcgcttcgc     1260
gagtgcaagg acaacaatgg gcagccagtt ttcaatcggc tgacatctat gaagttcgag     1320
ggcggacgca gcagctattc cgtcaaggcc ttggaaaaat tgaatacctg gttcaatgat     1380
ccttggtggc ccgacgaagg ctcaggggcc gagcgtggtg acgaaatcga tgaagacgca     1440
gcactacggg tctgctatcc acatcttttt acgcagcccc aagagctgct ccaacgactc     1500
gaggccgctc cgaccacggg caacgacgtg gttgacggag ccttgcgcga attacgcaag     1560
gtcatcaacc aatgcattga cgctttgggt gagaggccag aggaaatcgt cgtcgaaatg     1620
gcacgagaga tcggcaaggg cgtcgtttgg cggaaagagc aggaaaaccg catacggcag     1680
aatgaactcg cccgaaggaa aattgccagc gaactggaaa agcacggact gagcgccaac     1740
aacacccgga tactgcgcta tcaactctgg gaagagcagg atttgcactg gtgcccctac     1800
tgcgcccatc ccattaatct ggaagcagcc acctcgggca tgacacacat agagcacgtc     1860
ctgccacgct cgctcaccca gatcgggcgc aaacgcagcg aactggtgct ggcccacgcc     1920
ggttgcaaca acctgaaagc cgatcagaca ccttggcaag catttggcca tgatgtcgag     1980
cgctggtctg cagtagaacg cgctgccgcc cgttttcaag agctgggcaa gaagtcttac     2040
gccaaggacc gcatcaaggc gatgggcttc taccgcaagg cggaacttct cctgctgaag     2100
gattacgaaa gcgaagtact gagcgacgaa tccatagccg acttcgccga ccgccagtta     2160
catcagacct cctggatcgc caaggctgca gcccagtggt tgcgcaccat caccccgctg     2220
gtttccgtct ctcgcggtga attcaccgcc ctactacgcc atcaatggcg actcgacacc     2280
gtgatcgcag aagcgcgcct tgatgaaaaa cttcctgttc tggatatcga tgcgtgcccc     2340
gtatctccgg aagcattcca gcagttccgg aaacaatggg aagggcatcc accagacaac     2400
ctggccgaac ggaccgagcg caaactggaa aaacgcctcg accatcgcca ccacggcata     2460
gatgccttgg tcatcgcgct caccagccga agcctctaca tgtctctggc ccggcgctac     2520
gttgaagaaa gcgaaaggcg cgcccgcggc gagagagtcc ggcatgattg gtccatcgag     2580
ccgactatgc acaatctgcg caaccaagcg ctgggtatgg tccgtacttg caacctgacc     2640
cacaagcctg accgcaaccc agccggccga ctattcaagg acaccgccta tggcgtccac     2700
tttccagagg agggcgatcg ggtacagctg acgctgcgca aacctttgac cagcctggcc     2760
gacgaaaagt ctgccgagaa gactcgcaag aacctgcaca gcattgccag cagtgaggta     2820
cgcctactcg ttctgaaagc attcgaagcg cgcctcagtg tcgggcagaa tccgaaacag     2880
gcgctctccg aaccggtacc ctaccccgcc tatggcaccg caatctggcg agtccgctgc     2940
atgcaaggct acgcggacga tgccgtccgt attgtccata aaagccgtca gggcgaacac     3000
gaaaagcacc tgctcaacga tggctatgcc tgcttggaaa taaccgctgg ggaaaatggc     3060
aaacaccaag tacgccttgt cactcagcgt gaagcacaag gccgcggctt catggataac     3120
cggcagcagg cgaaacgcat attcaaggga gatacggtga tcgaccggcg cgacgaccgt     3180
aaatacctag tgggctactt caaggccgag ggctatattt tcctcctccc ccacacggac     3240
acccgcaact tcgacaagat caaggaggcg gactcgggca agaagaaagt ttccttcaac     3300
caagcgtacc aacttgagcg catctag                                         3327

<210>  46
<211>  3327
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Cas endonuclease of Locus 28

<400>  46
atggcataca aattaggtat cgatctgggc accgcttcca tcggtgcggt tgccattcgt       60
attgaaaata aggtgcctat cagcgttgac tggcatgcag tgcgcatttt cagcgagccc      120
gtcgtaaaca ctcagaaagg gctcacgccc aaaaagacgg cccgtcgtga agcccggcaa      180
ttgcgtaaac aggtcgaacg acgagcccga cggttgcgcc gtattgccaa tctgattcca      240
ttgctggggt tgcagaaagc cgaagtaaag cttgggcgcc gtcaggactt gaccacgttg      300
cgagctattg ccgcgcgcga gaaggtcgaa ctacatgagt ttgccctggt actgctgcgt      360
attgccaaac gccgcggtta cgccggtgga tttcgcgatt ccgaaggcgg cgtggtcaag      420
actgccagtg acaaactgag cgtggaaatg agagctcttg ccgagacgcg aggcctgcaa      480
cagataactc tgggcgaata cttactgcat cgacagcaac gagggctgcc tatctggctc      540
aaagctgagc gtccaggctt ggaaccgctc tatgctctgc gggagatggt aaccgccgaa      600
ttcgaacaaa tctggacaat ccaagccaaa tgccatccga tcctgaacag ctgtcatctc      660
gaaaaaccac ttaagcaatg gttctatcaa gcactgttct atcagcgacc actgaaatct      720
cccgcccaca tggtcggcaa ttgcctgctt gaacccaatt tgccacgcgc cccacgcgct      780
caaatggcag cccaacgctt caggatagaa aaaacgcttc acgatttacg ctggggtggc      840
ggacgacagg ctgaacgcct gaacacagcg caactcgacc tactgcgtca gactctgagc      900
gatccaacca atgttgatag caaggtcagc tttaagcgcc tgtaccaagc cctgaacgag      960
gctgggttga acgatccgcg aaatcgcaca ttaaacctgg agcgcagcag tcgcgatcag     1020
ttacttggca atagcaccgt tgcccgttgg cgcgcgctgg gcctgcaaga tcaatggctg     1080
atgctggctc ctcgcgacca gacatctgtt atcaacctgc tggcagactt gggtggtccg     1140
gaaatactga ccccagacga ctggcaccag aacatccgta aaagcagtgc caaggacgac     1200
aacaccaaag cctatcgtcg attccggcag gaagttattg atttcatcga tgcgcttcgc     1260
cggtgcatag atagtaatgg ccagccggtt ttcaatcgtc tttccgctat gaagttcgac     1320
ggcggacgca gtagctactc ggtaaaggcc ttggaaaaga tgaacgaatg gttcaataac     1380
ccgtggtggc ccaatgaagg tccaggctca gagcgtcgcg gcgagatcga cgaagaagtg     1440
gcgatacggg tgtgttaccc acatctttat acgcaatctc aagagctgca cccgcgactc     1500
gaagccgctc cgaccaccgg caacgacgtt gtcgatggag cattacgcga actgcgcaag     1560
gtcatcaacc aatgcattga cgagcaaggt gagaaaccac aggaaatcat catcgaattg     1620
gcaagagagg tcgggaaagg tgtggctttg cggaatgaac aggaaagtcg cattcggaac     1680
aacgaactcg ccaggcggaa aattgccagc gaacttgaag ggcacggttt gattgccagc     1740
agcacccgga tactgcgata tcaactctgg gaggagcaag agcgacactg gtgtccttat     1800
tgcgcacttc ccatcagcct ggaagcagcc atctcaaaca tgacgcacat agaacacgtc     1860
ctgccccgtt cgctcaccca agtcggtcga aaacgcagtg aactggtgct agcccatgct     1920
ggttgcaatc atctgaaagc cgaccagacg ccttggcaag ccttcggcca cgatgccgag     1980
cgctggtctg cagtagaacg tgctgccgcc cgatttcagg agctgggtaa aaagtgctat     2040
ttcaaagaca gggcgaaggc gatgggttgc ttccgaaaat cagcccttct catgctgaag     2100
gattatgaaa gtgaagtatt aaacgacgaa tccatagccg gattcgccaa ccgtcagtta     2160
caccagacat cttggattgc caaggttgca gcccaatggt tacgtacgat ttcaccgctg     2220
atatccgttt cccgcggcga attcaccgcc ctgctgcgcc atcaatggcg actagacacc     2280
gttatcgcag aaacgcgcta tggtgaaaaa cttcccgttc tggatatcga tggcaatccc     2340
gtccatccgg aagaatttca gcacttccgg aaacaatggg aaggacatcc accggacaac     2400
cccgccgaaa gaaccgagcg caaactggaa aagcgcttcg accaccgcca ccatggcatt     2460
gatgccctgg tcatcgcgct caccagccgt agtttgtaca tgtctcttgc tcggcgctat     2520
gtagaagaaa gcaaaaagcg cgcccgcggc gagaaagtcc ggcgtgactg gtccattgag     2580
ccacctatgc acaatttgcg cggccaagct ctggatatga tccgcgcgtg caacctgacc     2640
ctcaagcccg accgcaacgc tgccggccga ctgtttgagg actacgccta tggcgtccac     2700
ttttctgacg caagcgagcg ggcacagctt acgcggcgca aaacattgat agatcttgca     2760
gacgaaaagt ccgcagagaa gactcgcaaa aatctccaga gcatcgcaag ccctgaggta     2820
cgccagatcg ttgtggaagc gctccaaatg cgcctaagtg ccgggcaaaa tccgaaacag     2880
gcgctctcca aacccgtact ctaccccgct tacggtacag aaatttggag ggtccgttgc     2940
ttacaaggct acgcggacca tgccgtgcga atcgttcaca atagccgcca gggtgaacac     3000
gaaaagtgtc tgctcaacga tggctatgcc tgcctggaga taagggccgg ggaaaatggc     3060
aaacaccaag cacgtctcgt cactcagcgg gaagcacagg gtcgtgactt catggaaacc     3120
cagcagcagg cgaagcgcct attcaaggga gatacggtga tcgacaggcg cgatgatcgt     3180
aaataccgag tgggttattt caccgccgag ggcaatattt tcctcatccc cttcgaggac     3240
actcgtaatt tcgataaaat caatgagcgg aactcgggca agaaaaaggt ttccttcaac     3300
caagcgcatc gacttgagcg agtatga                                         3327

<210>  47
<211>  1093
<212>  PRT
<213>  Bacillus cereus

<400>  47
Met Ala Tyr Thr Met Gly Ile Asp Val Gly Ile Ala Ser Cys Gly Trp 
1               5                   10                  15      
Ala Ile Val Asp Leu Glu Arg Gln Arg Ile Ile Asp Leu Gly Val Arg 
            20                  25                  30          
Thr Phe Glu Lys Ala Glu Asn Pro Lys Asn Gly Glu Ala Leu Ala Val 
        35                  40                  45              
Pro Arg Arg Glu Ala Arg Ser Ser Arg Arg Arg Leu Arg Arg Lys Lys 
    50                  55                  60                  
His Arg Ile Glu Arg Leu Lys His Met Phe Ile Arg Asn Gly Leu Ala 
65                  70                  75                  80  
Val Asp Ile Gln His Leu Glu Gln Gln Thr Leu Arg Ser Gln Asn Glu 
                85                  90                  95      
Ile Asp Val Trp Gln Leu Arg Val Asp Gly Leu Asp Arg Met Leu Thr 
            100                 105                 110         
Gln Lys Glu Trp Leu Arg Val Leu Ile His Leu Ala Gln Arg Arg Gly 
        115                 120                 125             
Phe Gln Ser Asn Arg Lys Thr Asp Gly Ser Ser Glu Asp Gly Gln Val 
    130                 135                 140                 
Leu Val Asn Val Thr Glu Asn Asp Arg Leu Met Glu Glu Lys Asp Tyr 
145                 150                 155                 160 
Arg Thr Val Ala Glu Met Met Val Lys Asp Glu Lys Phe Ser Asp His 
                165                 170                 175     
Lys Arg Asn Lys Asn Gly Asn Tyr His Gly Val Val Ser Arg Ala Ser 
            180                 185                 190         
Leu Leu Val Glu Ile His Thr Leu Phe Glu Ser Gln Arg Gln His His 
        195                 200                 205             
Asn Phe Leu Ala Ser Lys Asp Phe Glu Leu Glu Tyr Val Asn Ile Trp 
    210                 215                 220                 
Ser Ser Gln Arg Pro Val Ala Thr Lys Asp Gln Ile Glu Lys Met Ile 
225                 230                 235                 240 
Gly Thr Cys Thr Phe Leu Pro Lys Glu Lys Arg Thr Pro Lys Ala Ser 
                245                 250                 255     
Trp His Phe Gln Tyr Phe Met Leu Leu Gln Thr Ile Asn His Ile Arg 
            260                 265                 270         
Ile Thr Asn Ile Gln Gly Thr Arg Ser Leu Asn Lys Glu Glu Ile Glu 
        275                 280                 285             
Gln Val Val Asn Met Ala Leu Thr Lys Ser Lys Val Ser Tyr His Asp 
    290                 295                 300                 
Ile Arg Lys Val Leu Asp Leu Ser Glu Glu Tyr Gln Phe Val Gly Leu 
305                 310                 315                 320 
Asp Tyr Gly Lys Glu Asn Glu Lys Lys Lys Val Glu Ser Lys Glu Thr 
                325                 330                 335     
Ile Ile Lys Leu Asp Asp Tyr His Lys Leu Asn Lys Ile Phe Asn Glu 
            340                 345                 350         
Val Glu Leu Ala Lys Gly Glu Ala Trp Lys Ala Val Asp Tyr Asp Thr 
        355                 360                 365             
Val Ala Tyr Ala Leu Thr Phe Phe Lys Asp Asp Glu Asp Ile Arg Asp 
    370                 375                 380                 
Tyr Leu Gln Asn Lys Tyr Lys Asp Ser Lys Asn Arg Leu Val Lys Asn 
385                 390                 395                 400 
Val Ala Asn Lys Glu Tyr Thr Asn Glu Leu Val Glu Lys Val Ser Thr 
                405                 410                 415     
Leu Ser Phe Arg Lys Val Gly His Leu Ser Leu Lys Ala Leu Arg Lys 
            420                 425                 430         
Ile Ile Pro Phe Leu Glu Gln Gly Met Thr Tyr Asp Lys Ala Cys Gln 
        435                 440                 445             
Ala Ala Gly Phe Asn Phe Gln Gly Ile Ser Lys Lys Lys Arg Ser Val 
    450                 455                 460                 
Val Leu Pro Val Ile Asp Gln Ile Ser Asn Pro Val Val Asn Arg Ala 
465                 470                 475                 480 
Leu Thr Gln Thr Arg Lys Val Ile Asn Ala Leu Ile Lys Lys Tyr Gly 
                485                 490                 495     
Ser Pro Glu Thr Ile His Ile Glu Thr Ala Arg Glu Leu Ser Lys Arg 
            500                 505                 510         
Phe Asp Glu Arg Lys Asn Ile Thr Lys Asp Tyr Lys Glu Asn Arg Asp 
        515                 520                 525             
Lys Asn Glu Arg Ala Lys Lys His Leu Ser Glu Leu Gly Ile Ile Asn 
    530                 535                 540                 
Pro Thr Gly Leu Asp Ile Val Lys Tyr Lys Leu Trp Cys Glu Gln Gln 
545                 550                 555                 560 
Gly Arg Cys Met Tyr Ser Asn Gln Pro Ile Ser Phe Glu Arg Leu Arg 
                565                 570                 575     
Glu Ser Gly Tyr Thr Glu Val Asp His Ile Ile Pro Tyr Ser Arg Ser 
            580                 585                 590         
Met Asn Asp Ser Tyr Asn Asn Arg Val Leu Val Met Thr Arg Glu Asn 
        595                 600                 605             
Arg Glu Lys Ser Asn Gln Thr Pro Tyr Glu Tyr Met Gly Asn Asp Thr 
    610                 615                 620                 
Gln Arg Trp Asp Glu Phe Glu Gln Arg Val Thr Thr Asn Pro Gln Ile 
625                 630                 635                 640 
Lys Lys Glu Lys Arg Gln Asn Leu Leu Leu Lys Gly Phe Thr Asn Arg 
                645                 650                 655     
Arg Glu Leu Glu Met Leu Glu Arg Asn Leu Asn Asp Thr Arg Tyr Ile 
            660                 665                 670         
Thr Lys Tyr Leu Ser His Phe Ile Ser Thr Asn Leu Glu Phe Ser Pro 
        675                 680                 685             
Ser Asp Lys Lys Lys Lys Val Val Asn Thr Ser Gly Arg Ile Thr Ser 
    690                 695                 700                 
His Leu Arg Ser Arg Trp Gly Leu Glu Lys Asn Arg Glu Gln Asn Asp 
705                 710                 715                 720 
Leu His His Ala Met Asp Ala Val Val Ile Ala Val Thr Ser Asp Ser 
                725                 730                 735     
Phe Ile Gln Gln Val Thr Asn Tyr Tyr Lys Arg Lys Glu Arg Arg Glu 
            740                 745                 750         
Leu Asn Arg Asp Asp Lys Phe Pro Leu Pro Trp Lys Phe Phe Arg Glu 
        755                 760                 765             
Glu Val Ile Ala Arg Leu Ser Pro Asn Pro Lys Glu Gln Ile Glu Ala 
    770                 775                 780                 
Leu Pro Asn His Phe Tyr Ser Glu Asp Glu Leu Ala Asp Leu Gln Pro 
785                 790                 795                 800 
Ile Phe Val Ser Arg Met Pro Lys Arg Ser Ile Thr Gly Glu Ala His 
                805                 810                 815     
Gln Ala Gln Phe Arg Arg Val Val Gly Lys Thr Lys Glu Gly Lys Asn 
            820                 825                 830         
Ile Thr Ala Lys Lys Thr Ala Leu Val Asp Ile Ser Tyr Asp Lys Asn 
        835                 840                 845             
Gly Asp Phe Asn Met Tyr Gly Arg Glu Thr Asp Pro Ala Thr Tyr Glu 
    850                 855                 860                 
Ala Ile Lys Glu Arg Tyr Leu Glu Phe Gly Gly Asn Ala Lys Lys Ala 
865                 870                 875                 880 
Phe Ser Thr Asp Leu His Lys Pro Lys Lys Asp Gly Thr Lys Gly Pro 
                885                 890                 895     
Leu Ile Lys Ser Val Arg Ile Met Glu Asn Lys Thr Leu Val His Pro 
            900                 905                 910         
Val Asn Lys Gly Lys Gly Val Val Tyr Asn Ser Ser Ile Val Arg Thr 
        915                 920                 925             
Asp Val Phe Gln Arg Lys Glu Lys Tyr Tyr Leu Leu Pro Val Tyr Val 
    930                 935                 940                 
Thr Asp Val Thr Lys Gly Lys Leu Pro Asn Lys Val Ile Val Ala Lys 
945                 950                 955                 960 
Lys Gly Tyr Asp Asp Trp Ile Glu Val Asp Asp Ser Phe Thr Phe Leu 
                965                 970                 975     
Tyr Ser Leu Tyr Pro Asn Asp Leu Ile Phe Ile Arg Gln Asn Pro Lys 
            980                 985                 990         
Lys Lys Ile Ser Leu Lys Lys Arg  Ile Glu Ser His Ser  Ile Ser Asp 
        995                 1000                 1005             
Ser Lys  Glu Val Gln Glu Ile  Leu Ala Tyr Tyr Lys  Gly Val Asp 
    1010                 1015                 1020             
Ser Ser  Thr Ala Ala Ile Glu  Phe Ile Thr His Asp  Gly Ser Tyr 
    1025                 1030                 1035             
Tyr Ala  Lys Gly Val Gly Val  Gln Asn Leu Asp Cys  Phe Glu Lys 
    1040                 1045                 1050             
Tyr Gln  Val Asp Thr Leu Gly  Asn Tyr Ser Lys Val  Lys Gly Glu 
    1055                 1060                 1065             
Lys Arg  Leu Glu Leu Glu Thr  Ser Asp Asn Asn Asp  Lys Gly Lys 
    1070                 1075                 1080             
Asp Val  Asn Ser Ile Lys Ser  Thr Ser Arg 
    1085                 1090             

<210>  48
<211>  1092
<212>  PRT
<213>  Brevibacillus laterosporus

<400>  48
Met Ala Tyr Thr Met Gly Leu Asp Val Gly Ile Ala Ser Cys Gly Trp 
1               5                   10                  15      
Ala Ile Val Asp Ile Glu Arg Gln Arg Ile Ile Asp Val Gly Val Arg 
            20                  25                  30          
Ile Phe Glu Lys Ala Glu Asn Pro Lys Asn Gly Glu Ala Leu Ala Val 
        35                  40                  45              
Pro Arg Arg Glu Ala Arg Ser Ser Arg Arg Arg Leu Arg Arg Lys Lys 
    50                  55                  60                  
His Arg Ile Glu Arg Leu Lys His Met Phe Ile Arg Asn Arg Leu Ala 
65                  70                  75                  80  
Val Asp Ile Gln His Leu Glu Gln Thr Leu Arg Ser Gln Asn Glu Ile 
                85                  90                  95      
Asp Val Trp Gln Leu Arg Val Asp Gly Leu Asp Arg Val Leu Thr Gln 
            100                 105                 110         
Lys Glu Trp Leu Arg Val Leu Ile His Leu Ala Gln Arg Arg Gly Phe 
        115                 120                 125             
Gln Ser Asn Arg Lys Thr Asp Gly Leu Asn Glu Asp Gly Gln Val Leu 
    130                 135                 140                 
Val Asn Val Ser Glu Asn Glu Arg Leu Met Glu Lys Lys Asp Tyr Arg 
145                 150                 155                 160 
Thr Val Ala Glu Met Met Val Lys Asp Gly Lys Phe Ser Asp His Lys 
                165                 170                 175     
Arg Asn Lys Asn Gly Asn Tyr His Gly Val Val Ser Arg Ala Ser Ile 
            180                 185                 190         
Leu Val Glu Ile His Ala Leu Phe Glu Ser Gln Arg Gln His His Asn 
        195                 200                 205             
Phe Phe Ala Ser Lys Asp Phe Glu Leu Glu Tyr Val Asn Ile Trp Ser 
    210                 215                 220                 
Ser Gln Arg Pro Val Ala Thr Lys Asp Gln Ile Glu Lys Met Ile Gly 
225                 230                 235                 240 
Thr Cys Thr Phe Leu Pro Lys Glu Lys Arg Ala Pro Lys Ala Ser Trp 
                245                 250                 255     
His Phe Gln Tyr Phe Met Leu Leu Gln Thr Ile Asn His Ile Arg Ile 
            260                 265                 270         
Thr Tyr Leu Gln Val Thr Arg Ser Leu Asn Lys Glu Glu Ile Glu Gln 
        275                 280                 285             
Val Val Asn Met Ala Leu Thr Lys Ser Lys Val Ser Tyr His Asp Ile 
    290                 295                 300                 
Arg Lys Ile Leu Asp Leu Ser Glu Glu Tyr Gln Phe Val Gly Leu Asp 
305                 310                 315                 320 
Tyr Gly Lys Glu Asp Glu Lys Lys Lys Val Glu Ser Lys Glu Thr Ile 
                325                 330                 335     
Ile Lys Leu Asp Asp Tyr His Lys Leu Asn Lys Ile Phe Asn Glu Val 
            340                 345                 350         
Glu Phe Ala Lys Gly Glu Thr Trp Glu Ala Val Asp Tyr Asp Thr Val 
        355                 360                 365             
Ala Tyr Ala Leu Thr Phe Phe Lys Asp Asp Glu Asp Ile Arg Asp Tyr 
    370                 375                 380                 
Leu Gln Asn Lys Tyr Lys Asp Ser Lys Asn Arg Leu Val Lys Asn Leu 
385                 390                 395                 400 
Ala Asn Lys Glu Tyr Thr Asn Glu Leu Ile Glu Lys Val Ser Thr Leu 
                405                 410                 415     
Ser Phe Arg Lys Val Gly His Leu Ser Leu Lys Ala Leu Arg Lys Ile 
            420                 425                 430         
Ile Pro Phe Leu Glu Gln Gly Met Thr Tyr Asp Lys Ala Cys Gln Ala 
        435                 440                 445             
Ala Gly Phe Asp Phe Gln Gly Ile Ser Lys Lys Lys Arg Tyr Val Val 
    450                 455                 460                 
Leu Pro Val Ile Asp Gln Ile Ser Asn Pro Val Val Asn Arg Ala Leu 
465                 470                 475                 480 
Thr Gln Thr Arg Lys Val Ile Asn Ala Leu Ile Lys Lys Tyr Gly Ser 
                485                 490                 495     
Pro Glu Thr Ile His Ile Glu Thr Ala Arg Glu Leu Ser Lys Thr Phe 
            500                 505                 510         
Asp Glu Arg Lys Asn Ile Thr Lys Asp Tyr Lys Glu Asn Arg Asp Lys 
        515                 520                 525             
Asn Glu His Ala Lys Lys His Leu Ser Glu Leu Gly Ile Ile Asn Pro 
    530                 535                 540                 
Thr Gly Leu Asp Ile Val Lys Tyr Lys Leu Trp Cys Glu Gln Gln Gly 
545                 550                 555                 560 
Arg Cys Met Tyr Ser Asn Arg Pro Ile Ser Phe Glu Arg Leu Lys Glu 
                565                 570                 575     
Ser Gly Tyr Thr Glu Val Asp His Ile Ile Pro Tyr Ser Arg Ser Met 
            580                 585                 590         
Asn Asp Ser Tyr Asn Asn Arg Val Leu Val Met Thr Arg Glu Asn Arg 
        595                 600                 605             
Glu Lys Gly Asn Gln Thr Pro Phe Glu Tyr Met Gly Asn Asp Thr Gln 
    610                 615                 620                 
Arg Trp Tyr Glu Phe Glu Gln Arg Val Thr Thr Asn Pro Gln Ile Lys 
625                 630                 635                 640 
Lys Glu Lys Arg Gln Asn Leu Leu Leu Lys Gly Phe Thr Asn Arg Arg 
                645                 650                 655     
Glu Leu Glu Met Leu Glu Arg Asn Leu Asn Asp Thr Arg Tyr Ile Thr 
            660                 665                 670         
Lys Tyr Leu Ser His Phe Ile Ser Thr Asn Leu Glu Phe Ser Pro Ser 
        675                 680                 685             
Asp Lys Lys Lys Lys Val Val Asn Thr Ser Gly Arg Ile Thr Ser His 
    690                 695                 700                 
Leu Arg Ser Arg Trp Gly Leu Glu Lys Asn Arg Glu Gln Asn Asp Leu 
705                 710                 715                 720 
His His Ala Met Asp Ala Val Val Ile Ala Val Thr Ser Asp Ser Phe 
                725                 730                 735     
Ile Gln Gln Val Thr Asn Tyr Tyr Lys Arg Lys Glu Arg Arg Glu Leu 
            740                 745                 750         
Asn Gly Asp Asp Lys Phe Pro Leu Pro Trp Lys Phe Phe Arg Glu Glu 
        755                 760                 765             
Val Ile Ala Arg Leu Ser Pro Asn Pro Lys Glu Gln Ile Glu Ala Leu 
    770                 775                 780                 
Pro Asn His Phe Tyr Ser Glu Asp Glu Leu Ala Asp Leu Gln Pro Ile 
785                 790                 795                 800 
Phe Val Ser Arg Met Pro Lys Arg Ser Ile Thr Gly Glu Ala His Gln 
                805                 810                 815     
Ala Gln Phe Arg Arg Val Val Gly Arg Thr Lys Glu Gly Lys Asn Ile 
            820                 825                 830         
Thr Ala Lys Lys Thr Ala Leu Val Asp Ile Gly Tyr Asp Lys Asn Gly 
        835                 840                 845             
Asp Phe Asn Met Tyr Gly Lys Glu Thr Asp Pro Ala Thr Tyr Glu Ala 
    850                 855                 860                 
Ile Lys Gln Arg Tyr Leu Glu Phe Gly Gly Asn Ala Lys Lys Ala Phe 
865                 870                 875                 880 
Ser Met Asp Leu His Lys Pro Lys Lys Asp Gly Ala Asn Gly Pro Leu 
                885                 890                 895     
Ile Lys Ser Val Arg Ile Met Asp Asn Lys Thr Leu Val His Pro Val 
            900                 905                 910         
Asn Lys Gly Lys Gly Val Val Tyr Asn Ser Ser Ile Val Arg Thr Asp 
        915                 920                 925             
Val Tyr Gln Arg Lys Glu Lys Tyr Tyr Leu Leu Pro Val Tyr Val Thr 
    930                 935                 940                 
Asp Val Thr Lys Ala Lys Leu Pro Asn Lys Val Ile Val Ala Lys Lys 
945                 950                 955                 960 
Gly Tyr Asp Asp Trp Ile Glu Val Asp Asp Ser Phe Thr Phe Leu Phe 
                965                 970                 975     
Ser Leu Tyr Pro Asn Asp Leu Ile Phe Val Arg Gln Asn Gln Lys Lys 
            980                 985                 990         
Lys Ile Ser Leu Lys Lys Arg Ile  Glu Ser His Phe Ile  Ser Asp Ser 
        995                 1000                 1005             
Lys Lys  Val Gln Glu Ile Leu  Ala Tyr Tyr Lys Gly  Val Asp Ser 
    1010                 1015                 1020             
Ala Ser  Ala Thr Ile Glu Phe  Ile Thr His Asp Gly  Ser Tyr Tyr 
    1025                 1030                 1035             
Ala Lys  Ser Val Gly Val Gln  Asn Leu Asp Cys Phe  Glu Lys Tyr 
    1040                 1045                 1050             
Gln Val  Asp Ile Leu Gly Asp  Tyr Ser Lys Val Lys  Gly Glu Lys 
    1055                 1060                 1065             
Arg Leu  Glu Leu Glu Thr Ser  Asp Ser Asn His Lys  Gly Lys Asp 
    1070                 1075                 1080             
Val Asn  Ser Ile Lys Ser Thr  Ser Arg 
    1085                 1090         

<210>  49
<211>  1070
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Cas-Locus 8

<400>  49
Met Arg Glu Leu Asp Tyr Arg Ile Gly Leu Asp Ile Gly Thr Asn Ser 
1               5                   10                  15      
Ile Gly Trp Gly Val Ile Glu Leu Ser Trp Asn Lys Asp Arg Glu Gln 
            20                  25                  30          
Tyr Glu Lys Ala Arg Ile Val Asp Lys Gly Val Arg Met Phe Asp Lys 
        35                  40                  45              
Ala Glu Ile Pro Lys Thr Gly Ala Ser Leu Ala Glu Pro Arg Arg Ile 
    50                  55                  60                  
Ala Arg Ser Ser Arg Arg Arg Leu Asn Arg Lys Ser Gln Arg Lys Lys 
65                  70                  75                  80  
Asp Ile Arg Asn Leu Leu Val Gln His Glu Ile Ile Ser Gln Lys Glu 
                85                  90                  95      
Leu Ala Ser Leu Tyr Pro Leu Ser Lys Ser Ser Met Asp Ile Trp Asp 
            100                 105                 110         
Ile Arg Leu Asp Gly Leu Asp Arg Leu Leu Asp Arg Phe Glu Trp Ala 
        115                 120                 125             
Arg Leu Leu Ile His Leu Ala Gln Lys Arg Gly Phe Lys Ser Asn Arg 
    130                 135                 140                 
Lys Ser Glu Leu Lys Asp Val Glu Thr Gly Lys Val Leu Ser Ser Ile 
145                 150                 155                 160 
Gln Ala Asn Glu Lys Arg Leu Ser Leu Tyr Arg Thr Val Gly Glu Met 
                165                 170                 175     
Trp Met Lys Asn Met Asp Phe Ser Lys Tyr Gly Lys Arg Arg Asn Ser 
            180                 185                 190         
Pro Asn Glu Tyr Val Phe Ser Val Ser Arg Ala Asp Leu Glu Lys Glu 
        195                 200                 205             
Ile Val Thr Leu Phe Glu Ala Gln Arg Lys Phe His Ser Ser Tyr Ala 
    210                 215                 220                 
Ser Val Asp Leu Gln Lys Thr Tyr Leu Arg Ile Trp Ala His Gln Leu 
225                 230                 235                 240 
Pro Phe Ala Ser Gly Asn Ala Ile Val Asn Lys Val Gly Tyr Cys Ser 
                245                 250                 255     
Leu Leu Lys Gly Lys Glu Lys Arg Val Pro Lys Ala Thr Tyr Thr Phe 
            260                 265                 270         
Gln Tyr Phe Asn Thr Leu Asp Gln Ile Asn Arg Thr Arg Leu Gly Pro 
        275                 280                 285             
Asp Phe Gln Pro Phe Thr Lys Glu Gln Arg Asp Ile Ile Leu Asp Lys 
    290                 295                 300                 
Met Phe Gln Arg Thr Asp Tyr Tyr Lys Lys Lys Thr Ile Pro Glu Val 
305                 310                 315                 320 
Thr Tyr Tyr Asp Ile Arg Lys Trp Leu Ala Leu Asp Glu Thr Ile Gln 
                325                 330                 335     
Phe Lys Gly Leu Thr Tyr Asp Pro Asn Glu Glu Leu Lys Lys Ile Glu 
            340                 345                 350         
Leu Lys Pro Phe Ile Asn Leu Lys Pro Phe Tyr Glu Ile Lys Lys Val 
        355                 360                 365             
Val Thr Asn Tyr Ala Gln Lys Thr Asn Glu Val Phe Ser Thr Leu Asp 
    370                 375                 380                 
Tyr Asp Thr Val Ala Tyr Ala Leu Thr Val Tyr Lys Thr Asp Lys Asp 
385                 390                 395                 400 
Ile Arg Ser Tyr Leu Lys Arg Ser Asn Asn Leu Ser Lys Arg Cys Tyr 
                405                 410                 415     
Asp Asp Gln Leu Ile Glu Glu Leu Leu Thr Leu Ser Tyr Thr Lys Phe 
            420                 425                 430         
Gly His Leu Ser Phe Lys Ala Ile Asn His Val Leu Pro Ile Met Gln 
        435                 440                 445             
Glu Gly Arg Thr Tyr Gln Glu Ala Ile Asn Gln Leu Gly Tyr Asp Thr 
    450                 455                 460                 
Thr Asn Leu Lys Lys Glu Asn Arg Ser Met Phe Leu Pro Leu Ile Pro 
465                 470                 475                 480 
Asp Glu Ile Thr Asn Pro Ile Val Lys Arg Ala Leu Thr Gln Ala Arg 
                485                 490                 495     
Lys Val Val Asn Ala Ile Ile Arg Arg Tyr Gly Ser Pro Asn Ser Val 
            500                 505                 510         
His Ile Glu Leu Ala Arg Glu Leu Ser Lys Ser His Asp Glu Arg Lys 
        515                 520                 525             
Lys Ile Met Thr Ala His Asp Glu Asn Tyr Lys Lys Asn Lys Gly Ala 
    530                 535                 540                 
Ile Ser Ile Leu Ile Glu Asn Gly Ile Leu Asn Pro Thr Gly Tyr Asp 
545                 550                 555                 560 
Ile Val Arg Tyr Lys Leu Trp Lys Glu Gln Gly Glu Arg Cys Ala Tyr 
                565                 570                 575     
Ser Leu Lys Lys Ile Pro Ala Asn Thr Phe Phe Asn Glu Leu Lys Lys 
            580                 585                 590         
Glu Arg Ser Gly Pro Pro Val Leu Glu Val Asp His Ile Leu Pro Tyr 
        595                 600                 605             
Ser Gln Ser Phe Ile Asp Ser Tyr His Asn Lys Val Leu Val Tyr Gly 
    610                 615                 620                 
Asp Glu Asn Gln Lys Lys Gly Asn Arg Ile Pro Tyr Thr Phe Phe Ser 
625                 630                 635                 640 
Glu Glu Asn Lys Glu Trp Glu Ser Phe Glu Ser Tyr Val Arg Ser Asn 
                645                 650                 655     
Ser Phe Phe Ser Lys Lys Lys Arg Gly Tyr Leu Leu Lys Lys Ala Tyr 
            660                 665                 670         
Leu Pro Arg Glu Ser Asn Leu Ile Lys Glu Arg His Leu Asn Asp Thr 
        675                 680                 685             
Arg Tyr Ala Ser Ser Tyr Leu Lys Asn Phe Ile Glu Lys Asn Leu Lys 
    690                 695                 700                 
Phe Lys Glu Ala Glu Gly Ile Thr Arg Lys Lys His Val Gln Thr Val 
705                 710                 715                 720 
Asn Gly Val Ile Thr Ala His Leu Arg Lys Arg Trp Gly Leu Glu Lys 
                725                 730                 735     
Asp Arg Gln Glu Thr Tyr Leu His His Ala Met Asp Ala Ile Ile Val 
            740                 745                 750         
Ala Cys Thr Asp His His Met Val Thr Lys Val Thr Glu Tyr Tyr Gln 
        755                 760                 765             
Ile Lys Glu Ser Asn Lys Ser Ile Lys Lys Pro Tyr Phe Pro Leu Pro 
    770                 775                 780                 
Trp Met Gly Phe Arg Glu Glu Ile Leu Ser His Leu Glu Ser Gln Pro 
785                 790                 795                 800 
Ile Ala Arg Lys Ile Ser Glu Glu Leu Lys Ile Gly Tyr Gln Ser Ser 
                805                 810                 815     
Asp Tyr Ile Leu Val Ser Arg Met Pro Lys Arg Ser Val Thr Gly Ser 
            820                 825                 830         
Ala His Asp Gln Thr Val Met Lys Lys Gly Gly Ile Asp Lys Lys Gly 
        835                 840                 845             
Lys Thr Ile Ile Ile Lys Arg Val His Leu Lys Asp Ile Lys Phe Asp 
    850                 855                 860                 
Glu Asn Gly Asp Phe Lys Met Val Gly Lys Glu Gln Asp Leu Ala Thr 
865                 870                 875                 880 
Tyr Glu Ala Ile Lys Gln Arg Tyr Leu Glu Tyr Gly Lys Glu Ser Lys 
                885                 890                 895     
Lys Ala Phe Glu Thr Pro Leu Tyr Lys Pro Ser Lys Lys Gly Lys Gly 
            900                 905                 910         
Asn Leu Ile Lys Lys Ile Lys Val Glu Val Gln Thr Lys Ser Phe Val 
        915                 920                 925             
Arg Glu Val Asn Gly Gly Val Ala Gln Asn Gly Asp Leu Val Arg Ile 
    930                 935                 940                 
Asp Leu Phe Glu Lys Asp Asn Arg Tyr Tyr Met Val Pro Ile Tyr Val 
945                 950                 955                 960 
Val Asp Thr Val Arg Ser Glu Leu Pro Asn Lys Ala Val Lys Ser Ser 
                965                 970                 975     
Lys Gly Tyr Glu Gln Trp Leu Thr Ile Asp Asn Ser Phe Thr Phe Lys 
            980                 985                 990         
Phe Ser Leu Tyr Ser Tyr Asp Leu  Val Arg Leu Val Lys  Gly Asp Glu 
        995                 1000                 1005             
Asp Arg  Phe Leu Tyr Phe Ser  Thr Leu Asp Ile Asn  Ser Asp Arg 
    1010                 1015                 1020             
Leu Asn  Phe Lys Asp Val Asn  Lys Pro Ser Lys Gln  Ala Glu Tyr 
    1025                 1030                 1035             
Arg Tyr  Ser Leu Lys Thr Ile  Glu Asn Leu Glu Lys  Tyr Glu Val 
    1040                 1045                 1050             
Gly Val  Leu Gly Asp Leu Arg  Leu Val Arg Gln Glu  Thr Arg Lys 
    1055                 1060                 1065             
Ile Phe  
    1070 

<210>  50
<211>  1081
<212>  PRT
<213>  Bacillus cereus

<400>  50
Met Lys Tyr Val Leu Gly Leu Asp Ile Gly Ile Ala Ser Cys Gly Trp 
1               5                   10                  15      
Ala Val Ile Asn Gln Glu Lys His Arg Ile Glu Asp Leu Gly Val Arg 
            20                  25                  30          
Ile Phe Asp Lys Ala Glu His Pro Lys Asp Gly Lys Ser Leu Ala Ala 
        35                  40                  45              
Pro Arg Arg Glu Ser Arg Ser Thr Arg Lys Thr Leu Arg Arg Lys Lys 
    50                  55                  60                  
His Arg Met Gln Arg Ile Lys Val Leu Leu Val Lys Tyr Gly Leu Leu 
65                  70                  75                  80  
Ser Thr Thr Glu Ile Glu Asn Leu Tyr Glu Ser Ala Ser Glu Ile Asp 
                85                  90                  95      
Val Trp Asn Leu Arg Leu Asp Ala Leu Glu Arg Lys Leu Asn Gln Lys 
            100                 105                 110         
Glu Phe Ala Arg Val Leu Ile His Leu Ala Lys Arg Arg Gly Phe Lys 
        115                 120                 125             
Ser Asn Met Lys Glu Thr Ile Leu Ser Glu Asn Gly Gln Ile Leu Glu 
    130                 135                 140                 
Ser Ile Ser Glu Asn Gln Lys Ile Met Glu Gln Gln Asn Tyr Arg Thr 
145                 150                 155                 160 
Val Gly Glu Met Ile Val Lys Asp Asn Lys Phe Glu Asn His Lys Arg 
                165                 170                 175     
Asn Lys Asp Gly Thr Tyr Ile Gly Thr Val Thr Arg Gln Gln Leu Gln 
            180                 185                 190         
Asp Glu Ile His Met Ile Phe Asn Ala Gln Arg Leu Phe Ile Asn Asp 
        195                 200                 205             
Leu Ala Thr Glu Glu Phe Glu Ser Ser Tyr Leu Glu Ile Trp Ala Ser 
    210                 215                 220                 
Gln Arg Pro Tyr Ala Ser Lys Asp Gln Ile Glu Lys Met Ile Gly Tyr 
225                 230                 235                 240 
Cys Thr Leu Glu Pro Lys Glu Lys Arg Val Pro Lys Ala Ser Trp Ser 
                245                 250                 255     
Phe Gln Tyr Phe Val Ala Leu Gln Thr Ile Asn Asn Leu Arg Leu Ile 
            260                 265                 270         
Ser Lys Asp Arg Ile Glu Glu Leu Ser Phe Glu Glu Lys Lys Gln Ile 
        275                 280                 285             
Met Asn Leu Ala Leu Glu Lys Pro Ile Val Lys Tyr Ile Asp Ile Arg 
    290                 295                 300                 
Lys Leu Leu Ser Ile Ser Asn Glu Leu His Phe Asn Asn Leu Leu Tyr 
305                 310                 315                 320 
Ser Ala Asp Thr Val Asp Thr Thr Val Glu Asn Lys Lys Cys Ile Glu 
                325                 330                 335     
Leu Lys Glu Tyr His Ser Ile Asn Lys Val Tyr Lys Gln Ile Tyr Gly 
            340                 345                 350         
Lys Asn Ala Leu Asn Leu Leu Pro Ile Asp Tyr Asp Thr Ile Ala Tyr 
        355                 360                 365             
Gly Leu Thr Ile Phe Lys Asp Asp Lys Asp Ile Leu Glu Tyr Leu Gln 
    370                 375                 380                 
Asn Lys Tyr Ile Asn Thr Lys Gly Lys Thr Ile Ser Asn Leu Thr Lys 
385                 390                 395                 400 
Lys Thr Tyr Asp Asp Thr Phe Ile Gln Ala Leu Leu Thr Leu Asn Phe 
                405                 410                 415     
Thr Lys Met Gly His Leu Ser Phe Lys Ala Leu Lys Asn Ile Ile Pro 
            420                 425                 430         
Phe Leu Glu Glu Gly Met Ser Tyr Asp Lys Ala Cys Asp Lys Ala Gly 
        435                 440                 445             
Tyr Asn Phe Lys Gly Thr Ser Phe Thr Lys Lys Thr Lys Tyr Leu Pro 
    450                 455                 460                 
Val Ile Pro Gln Asn Thr Asn Pro Val Val His Arg Ala Leu Ser Gln 
465                 470                 475                 480 
Thr Arg Lys Val Ile Asn Ala Ile Ile Asn Lys Tyr Gly Ser Pro Val 
                485                 490                 495     
Ser Ile His Ile Glu Thr Ala Arg Glu Leu Ser Lys Thr Phe Gln Glu 
            500                 505                 510         
Arg Lys Glu Ile Asp Ser Met Tyr Gln Asp Asn Ser Lys Lys Asn Glu 
        515                 520                 525             
His Ala Ile Asn Lys Leu Lys Glu Leu Gly Asn Ile Asn Pro Ser Gly 
    530                 535                 540                 
Ile Asn Ile Val Lys Phe Lys Leu Trp Lys Glu Gln Asp Gly Arg Cys 
545                 550                 555                 560 
Met Tyr Ser Gly Glu Tyr Ile Glu Pro His Arg Leu Phe Glu Glu Gly 
                565                 570                 575     
Tyr Thr Glu Val Asp His Ile Leu Pro Tyr Ser Arg Ser Leu Asp Asp 
            580                 585                 590         
Ser Tyr Asn Asn Lys Thr Leu Ala Leu Gly Ile Glu Asn Gln Arg Lys 
        595                 600                 605             
Gly Asn Lys Thr Pro Tyr Glu Tyr Met Gly Asn Thr Ser Ile Trp Tyr 
    610                 615                 620                 
Lys Phe Glu Thr Arg Val Gln Ser Asn Lys Lys Ile Asn Lys Lys Lys 
625                 630                 635                 640 
Gln Gln Lys Leu Leu Leu Gln Tyr Phe Ser His Ala Arg Glu Gln Glu 
                645                 650                 655     
Phe Ile Glu Arg Asn Leu Asn Asp Thr Arg Tyr Ala Thr Ile Tyr Ile 
            660                 665                 670         
Ser Ala Phe Ile Gln Gln His Leu Ile Phe Ser Glu Ser Phe Ser Lys 
        675                 680                 685             
Lys Arg Val His Thr Val Ser Gly Ile Ile Thr Ser His Val Arg Ser 
    690                 695                 700                 
Arg Trp Gly Phe Asn Lys Asp Arg Lys Glu Ser His Ile His His Ala 
705                 710                 715                 720 
Leu Asp Ala Val Ile Val Ala Val Thr Ser Asp Gln Met Ile Gln Arg 
                725                 730                 735     
Val Thr Asn Tyr Tyr Lys Leu Lys Glu Leu Asn Arg Lys Leu Gln Ala 
            740                 745                 750         
Lys Gly Ile Leu Phe Pro Glu Pro Trp Glu Gly Phe Arg Leu Glu Leu 
        755                 760                 765             
Glu Ala Arg Ile Ser Pro Asn Thr Gln Gln Tyr Leu Lys Gly Ile Cys 
    770                 775                 780                 
Ser Lys Asn Tyr Ala Asp Ile Asn Leu Ser Glu Ile Lys Pro Ile Phe 
785                 790                 795                 800 
Val Ser Arg Met Pro Lys Arg Ser Ile Thr Gly Glu Leu His Gln Glu 
                805                 810                 815     
Thr Ile Arg Lys Phe Ile Gly Tyr Asn Glu Lys Gly Lys Val Leu Thr 
            820                 825                 830         
Ala Ile Lys Thr Lys Leu Glu Asp Ile Pro Phe Asp Ala Asn Gly Asp 
        835                 840                 845             
Phe Pro Met Tyr Gly Lys Glu Thr Asp Leu Tyr Thr Tyr Asn Ala Ile 
    850                 855                 860                 
Lys Glu Arg Tyr Leu Ser His Lys Lys Asp Lys Arg Lys Ser Phe Gln 
865                 870                 875                 880 
Glu Ser Leu Tyr Lys Pro Thr Lys Thr Gly Glu Ile Gly Pro Leu Ile 
                885                 890                 895     
Lys Ser Ile Lys Ile Ile Asp Thr Arg Thr Ile Val Asn Pro Val Asn 
            900                 905                 910         
Gln Gly Lys Gly Val Val Tyr Asn Ser Lys Ile Ala Arg Thr Asp Val 
        915                 920                 925             
Phe Lys Lys Asp Asp Lys Tyr Tyr Leu Ile Pro Ile Tyr Thr Ile Asp 
    930                 935                 940                 
Leu Met Lys Asn Val Leu Pro Gln Lys Ala Ile Thr Ala Gly Lys Gly 
945                 950                 955                 960 
Tyr Glu Asp Trp Ile Thr Ile Asp His Ser Phe Thr Phe Leu Phe Ser 
                965                 970                 975     
Leu Phe Pro Asn Asp Leu Ile Lys Ile Val Pro Ser Lys Asn Lys Glu 
            980                 985                 990         
Ile Lys Ala Arg Ser Thr Ser Ser  Lys Lys Glu Ile Leu  Leu Pro Ser 
        995                 1000                 1005             
Leu Thr  Gly Tyr Phe Lys Lys  Val His Ser Gly Thr  Ala Gly Ile 
    1010                 1015                 1020             
Thr Val  Glu Ser His Asp Gly  Arg Phe Ile Ala Asp  Ile Gly Ser 
    1025                 1030                 1035             
Lys Gln  Leu Leu Leu Phe Glu  Lys His Gln Val Asp  Val Leu Gly 
    1040                 1045                 1050             
His Tyr  Thr Lys Ile Lys Glu  Glu Lys Arg Ile Gly  Met Ser Thr 
    1055                 1060                 1065             
Cys Asn  Asp Asn Lys Lys Ser  Ser Ala Phe Gly Ser  Leu 
    1070                 1075                 1080     

<210>  51
<211>  1378
<212>  PRT
<213>  Lactobacillus fermentum

<400>  51
Met Lys Glu Tyr His Ile Gly Leu Asp Ile Gly Thr Ser Ser Ile Gly 
1               5                   10                  15      
Trp Ala Val Thr Asp Ser Gln Phe Lys Leu Met Arg Ile Lys Gly Lys 
            20                  25                  30          
Thr Ala Ile Gly Val Arg Leu Phe Glu Glu Gly Lys Thr Ala Ala Glu 
        35                  40                  45              
Arg Arg Thr Phe Arg Thr Thr Arg Arg Arg Leu Lys Arg Arg Lys Trp 
    50                  55                  60                  
Arg Leu His Tyr Leu Asp Lys Ile Phe Ala Pro His Leu Gln Glu Val 
65                  70                  75                  80  
Asp Glu Asn Phe Leu Arg Arg Leu Lys Gln Ser Asn Ile His Pro Glu 
                85                  90                  95      
Asp Pro Ala Lys Asn Gln Ala Phe Ile Gly Lys Leu Leu Phe Pro Asp 
            100                 105                 110         
Leu Leu Lys Lys Asn Glu Arg Gly Tyr Pro Thr Leu Ile Lys Met Arg 
        115                 120                 125             
Asp Glu Leu Pro Val Glu Gln Arg Ala His Tyr Pro Val Thr Asn Ile 
    130                 135                 140                 
Tyr Lys Leu Arg Glu Ala Met Ile Asn Glu Asp Arg Gln Phe Asp Leu 
145                 150                 155                 160 
Arg Glu Val Tyr Leu Ala Val His His Ile Val Lys Tyr Arg Gly His 
                165                 170                 175     
Phe Leu Asn Asn Ala Ser Val Asp Lys Phe Lys Val Gly Arg Ile Asp 
            180                 185                 190         
Phe Asp Lys Ser Phe Asn Val Leu Asn Glu Ala Tyr Glu Glu Leu Gln 
        195                 200                 205             
Asn Gly Glu Gly Ser Phe Thr Ile Glu Pro Ser Lys Val Glu Lys Ile 
    210                 215                 220                 
Gly Gln Leu Leu Leu Asp Thr Lys Met Arg Lys Leu Asp Arg Gln Lys 
225                 230                 235                 240 
Ala Val Ala Lys Leu Leu Glu Val Lys Val Ala Asp Lys Glu Glu Thr 
                245                 250                 255     
Lys Arg Asn Lys Gln Ile Ala Thr Ala Met Ser Lys Leu Val Leu Gly 
            260                 265                 270         
Tyr Lys Ala Asp Phe Ala Thr Val Ala Met Ala Asn Gly Asn Glu Trp 
        275                 280                 285             
Lys Ile Asp Leu Ser Ser Glu Thr Ser Glu Asp Glu Ile Glu Lys Phe 
    290                 295                 300                 
Arg Glu Glu Leu Ser Asp Ala Gln Asn Asp Ile Leu Thr Glu Ile Thr 
305                 310                 315                 320 
Ser Leu Phe Ser Gln Ile Met Leu Asn Glu Ile Val Pro Asn Gly Met 
                325                 330                 335     
Ser Ile Ser Glu Ser Met Met Asp Arg Tyr Trp Met His Glu Arg Gln 
            340                 345                 350         
Leu Ala Glu Val Lys Glu Tyr Leu Ala Thr Gln Pro Ala Ser Ala Arg 
        355                 360                 365             
Lys Asp Phe Asp Gln Val Tyr Asn Lys Tyr Ile Gly Gln Ala Pro Lys 
    370                 375                 380                 
Glu Lys Gly Phe Asp Leu Glu Lys Gly Leu Lys Lys Ile Leu Ser Lys 
385                 390                 395                 400 
Lys Glu Asn Trp Lys Glu Ile Asp Glu Leu Leu Lys Ala Gly Asp Phe 
                405                 410                 415     
Leu Pro Lys Gln Arg Thr Ser Ala Asn Gly Val Ile Pro His Gln Met 
            420                 425                 430         
His Gln Gln Glu Leu Asp Arg Ile Ile Glu Lys Gln Ala Lys Tyr Tyr 
        435                 440                 445             
Pro Trp Leu Ala Thr Glu Asn Pro Ala Thr Gly Glu Arg Asp Arg His 
    450                 455                 460                 
Gln Ala Lys Tyr Glu Leu Asp Gln Leu Val Ser Phe Arg Ile Pro Tyr 
465                 470                 475                 480 
Tyr Val Gly Pro Leu Val Thr Pro Glu Val Gln Lys Ala Thr Ser Gly 
                485                 490                 495     
Ala Lys Phe Ala Trp Ala Lys Arg Lys Glu Asp Gly Glu Ile Thr Pro 
            500                 505                 510         
Trp Asn Leu Trp Asp Lys Ile Asp Arg Ala Glu Ser Ala Glu Ala Phe 
        515                 520                 525             
Ile Lys Arg Met Thr Val Lys Asp Thr Tyr Leu Leu Asn Glu Asp Val 
    530                 535                 540                 
Leu Pro Ala Asn Ser Leu Leu Tyr Gln Lys Tyr Asn Val Leu Asn Glu 
545                 550                 555                 560 
Leu Asn Asn Val Arg Val Asn Gly Arg Arg Leu Ser Val Gly Ile Lys 
                565                 570                 575     
Gln Asp Ile Tyr Thr Glu Leu Phe Lys Lys Lys Lys Thr Val Lys Ala 
            580                 585                 590         
Gly Asp Val Ala Ser Leu Val Met Ala Lys Thr Arg Gly Val Asn Lys 
        595                 600                 605             
Pro Ser Val Glu Gly Leu Ser Asp Pro Lys Lys Phe Asn Ser Asn Leu 
    610                 615                 620                 
Ala Thr Tyr Leu Asp Leu Lys Ser Ile Val Gly Asp Lys Val Asp Asp 
625                 630                 635                 640 
Asn Arg Tyr Gln Met Asp Leu Glu Asn Ile Ile Glu Trp Arg Ser Val 
                645                 650                 655     
Phe Glu Asp Gly Glu Ile Phe Ala Asp Lys Leu Thr Glu Val Glu Trp 
            660                 665                 670         
Leu Thr Asp Glu Gln Arg Ser Ala Leu Val Lys Lys Arg Tyr Lys Gly 
        675                 680                 685             
Trp Gly Arg Leu Ser Lys Lys Leu Leu Thr Gly Ile Val Asp Glu Asn 
    690                 695                 700                 
Gly Gln Arg Ile Ile Asp Leu Met Trp Asn Thr Asp Gln Asn Phe Met 
705                 710                 715                 720 
Gln Ile Val Asn Gln Pro Val Phe Lys Glu Gln Ile Asp Gln Leu Asn 
                725                 730                 735     
Gln Lys Ala Ile Thr Asn Asp Gly Met Thr Leu Arg Glu Arg Val Glu 
            740                 745                 750         
Ser Val Leu Asp Asp Ala Tyr Thr Ser Pro Gln Asn Lys Lys Ala Ile 
        755                 760                 765             
Trp Gln Val Val Arg Val Val Glu Asp Ile Val Lys Ala Val Gly Asn 
    770                 775                 780                 
Ala Pro Lys Ser Ile Ser Ile Glu Phe Ala Arg Asn Glu Gly Asn Lys 
785                 790                 795                 800 
Gly Glu Ile Thr Arg Ser Arg Arg Thr Gln Leu Gln Lys Leu Phe Glu 
                805                 810                 815     
Asp Gln Ala His Glu Leu Val Lys Asp Thr Ser Leu Thr Glu Glu Leu 
            820                 825                 830         
Glu Lys Ala Pro Asp Leu Ser Asp Arg Tyr Tyr Phe Tyr Phe Thr Gln 
        835                 840                 845             
Gly Gly Lys Asp Met Tyr Thr Gly Asp Pro Ile Asn Phe Asp Glu Ile 
    850                 855                 860                 
Ser Thr Lys Tyr Asp Ile Asp His Ile Leu Pro Gln Ser Phe Val Lys 
865                 870                 875                 880 
Asp Asp Ser Leu Asp Asn Arg Val Leu Val Ser Arg Ala Glu Asn Asn 
                885                 890                 895     
Lys Lys Ser Asp Arg Val Pro Ala Lys Leu Tyr Ala Ala Lys Met Lys 
            900                 905                 910         
Pro Tyr Trp Asn Gln Leu Leu Lys Gln Gly Leu Ile Thr Gln Arg Lys 
        915                 920                 925             
Phe Glu Asn Leu Thr Met Asp Val Asp Gln Asn Ile Lys Tyr Arg Ser 
    930                 935                 940                 
Leu Gly Phe Val Lys Arg Gln Leu Val Glu Thr Arg Gln Val Ile Lys 
945                 950                 955                 960 
Leu Thr Ala Asn Ile Leu Gly Ser Met Tyr Gln Glu Ala Gly Thr Asp 
                965                 970                 975     
Ile Ile Glu Thr Arg Ala Gly Leu Thr Lys Gln Leu Arg Glu Glu Phe 
            980                 985                 990         
Asp Leu Pro Lys Val Arg Glu Val  Asn Asp Tyr His His  Ala Val Asp 
        995                 1000                 1005             
Ala Tyr  Leu Thr Thr Phe Ala  Gly Gln Tyr Leu Asn  Arg Arg Tyr 
    1010                 1015                 1020             
Pro Lys  Leu Arg Ser Phe Phe  Val Tyr Gly Glu Tyr  Met Lys Phe 
    1025                 1030                 1035             
Lys His  Gly Ser Asp Leu Lys  Leu Arg Asn Phe Asn  Phe Phe His 
    1040                 1045                 1050             
Glu Leu  Met Glu Gly Asp Lys  Ser Gln Gly Lys Val  Val Asp Gln 
    1055                 1060                 1065             
Gln Thr  Gly Glu Leu Ile Thr  Thr Arg Asp Glu Val  Ala Lys Ser 
    1070                 1075                 1080             
Phe Asp  Arg Leu Leu Asn Met  Lys Tyr Met Leu Val  Ser Lys Glu 
    1085                 1090                 1095             
Val His  Asp Arg Ser Asp Gln  Leu Tyr Gly Ala Thr  Ile Val Thr 
    1100                 1105                 1110             
Ala Lys  Glu Ser Gly Lys Leu  Thr Ser Pro Ile Glu  Ile Lys Lys 
    1115                 1120                 1125             
Asn Arg  Pro Val Asp Leu Tyr  Gly Ala Tyr Thr Asn  Gly Thr Ser 
    1130                 1135                 1140             
Ala Phe  Met Thr Ile Ile Lys  Phe Thr Gly Asn Lys  Pro Lys Tyr 
    1145                 1150                 1155             
Lys Val  Ile Gly Val Pro Thr  Thr Ser Ala Val Gly  Leu Lys Arg 
    1160                 1165                 1170             
Val Gly  Lys Pro Gly Ser Glu  Ser Tyr Asn Gln Glu  Leu His Arg 
    1175                 1180                 1185             
Ile Ile  Lys Ser Asn Pro Lys  Val Lys Lys Asp Phe  Glu Ile Val 
    1190                 1195                 1200             
Val Pro  His Val Ser Tyr Ser  Gln Leu Ile Val Asp  Gly Asp Cys 
    1205                 1210                 1215             
Lys Phe  Thr Leu Ala Ser Asp  Thr Tyr Gln His Pro  Ala Thr Gln 
    1220                 1225                 1230             
Leu Val  Leu Ser Lys Glu Ser  Met Glu Ile Ile Ala  Asp Asp Phe 
    1235                 1240                 1245             
Lys Phe  Val Lys Glu Asn Pro  Ala Thr Ala Asp Glu  Gln Leu Val 
    1250                 1255                 1260             
Arg Val  Phe Asp Glu Ile Val  Asn Gln Met Asn His  Tyr Phe Thr 
    1265                 1270                 1275             
Ile Phe  Asp Gln Arg Ser Asn  Arg Gln Lys Val Thr  Lys Ala Arg 
    1280                 1285                 1290             
Asp Lys  Phe Val Ser Leu Pro  Thr Glu Ser Glu Tyr  Glu Gly Ala 
    1295                 1300                 1305             
Lys Lys  Thr Gln Val Gly Lys  Thr Glu Val Ile Thr  Asn Leu Leu 
    1310                 1315                 1320             
Met Gly  Leu His Ala Asn Ala  Ala Gln Gly Asp Leu  Lys Val Leu 
    1325                 1330                 1335             
Gly Leu  Ser Thr Phe Gly Phe  Phe Gln Ser Ser Gly  Gly Leu Asn 
    1340                 1345                 1350             
Leu Ser  Glu Asp Ala Met Ile  Val Tyr Gln Ser Pro  Thr Gly Leu 
    1355                 1360                 1365             
Phe Glu  Arg Arg Ile Cys Leu  Lys Asp Ile 
    1370                 1375             

<210>  52
<211>  1337
<212>  PRT
<213>  Enterococcus faecalis

<400>  52
Met Lys Lys Asp Tyr Val Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      
Gly Trp Ala Val Met Thr Glu Asp Tyr Gln Leu Val Lys Lys Lys Met 
            20                  25                  30          
Pro Ile Tyr Gly Asn Thr Glu Lys Lys Lys Ile Lys Lys Asn Phe Trp 
        35                  40                  45              
Gly Val Arg Leu Phe Glu Glu Gly His Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  
Lys Arg Thr Ala Arg Arg Arg Ile Ser Arg Arg Arg Asn Arg Leu Arg 
65                  70                  75                  80  
Tyr Leu Gln Ala Phe Phe Glu Glu Ala Met Thr Ala Leu Asp Glu Asn 
                85                  90                  95      
Phe Phe Ala Arg Leu Gln Glu Ser Phe Leu Val Pro Glu Asp Lys Lys 
            100                 105                 110         
Trp His Arg His Pro Ile Phe Ala Lys Leu Glu Asp Glu Val Ala Tyr 
        115                 120                 125             
His Glu Thr Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Ala Asp 
    130                 135                 140                 
Ser Ser Glu Gln Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala Tyr 
145                 150                 155                 160 
Ile Val Lys Tyr Arg Gly His Phe Leu Ile Glu Gly Lys Leu Ser Thr 
                165                 170                 175     
Glu Asn Ile Ser Val Lys Glu Lys Phe Gln Gln Phe Met Ile Ile Tyr 
            180                 185                 190         
Asn Gln Thr Phe Val Asn Gly Glu Gly Arg Leu Val Ser Ala Pro Leu 
        195                 200                 205             
Pro Glu Ser Val Leu Ile Glu Glu Glu Leu Thr Glu Lys Ala Ser Arg 
    210                 215                 220                 
Thr Lys Lys Ser Glu Lys Val Leu Gln Gln Phe Pro Gln Glu Lys Ala 
225                 230                 235                 240 
Asn Gly Leu Phe Gly Gln Phe Leu Lys Leu Met Val Gly Asn Lys Ala 
                245                 250                 255     
Asp Phe Lys Lys Val Phe Gly Leu Glu Glu Glu Ala Lys Ile Thr Tyr 
            260                 265                 270         
Ala Ser Glu Ser Tyr Glu Glu Asp Leu Glu Gly Ile Leu Ala Lys Val 
        275                 280                 285             
Gly Asp Glu Tyr Ser Asp Val Phe Leu Ala Ala Lys Asn Val Tyr Asp 
    290                 295                 300                 
Ala Val Glu Leu Ser Thr Ile Leu Ala Asp Ser Asp Lys Lys Ser Tyr 
305                 310                 315                 320 
Ala Lys Leu Ser Ser Ser Met Ile Val Arg Phe Thr Glu His Gln Glu 
                325                 330                 335     
Asp Leu Lys Lys Phe Lys Arg Phe Ile Arg Glu Asn Cys Pro Asp Glu 
            340                 345                 350         
Tyr Asp Asn Leu Phe Lys Asn Glu Gln Lys Asp Gly Tyr Ala Gly Tyr 
        355                 360                 365             
Ile Ala His Ala Gly Lys Val Ser Gln Leu Lys Phe Tyr Gln Tyr Val 
    370                 375                 380                 
Lys Lys Ile Ile Gln Asp Ile Ala Gly Ala Glu Tyr Phe Leu Glu Lys 
385                 390                 395                 400 
Ile Ala Gln Glu Asn Phe Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly 
                405                 410                 415     
Val Ile Pro His Gln Ile His Leu Ala Glu Leu Gln Ala Ile Ile His 
            420                 425                 430         
Arg Gln Ala Ala Tyr Tyr Pro Phe Leu Lys Glu Asn Gln Glu Lys Ile 
        435                 440                 445             
Glu Gln Leu Val Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ser 
    450                 455                 460                 
Lys Gly Asp Ala Ser Thr Phe Ala Trp Leu Lys Arg Gln Ser Glu Glu 
465                 470                 475                 480 
Pro Ile Arg Pro Trp Asn Leu Gln Glu Thr Val Asp Leu Asp Gln Ser 
                485                 490                 495     
Ala Thr Ala Phe Ile Glu Arg Met Thr Asn Phe Asp Thr Tyr Leu Pro 
            500                 505                 510         
Ser Glu Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu Lys Phe Met 
        515                 520                 525             
Val Phe Asn Glu Leu Thr Lys Ile Ser Tyr Thr Asp Asp Arg Gly Ile 
    530                 535                 540                 
Lys Ala Asn Phe Ser Gly Lys Glu Lys Glu Lys Ile Phe Asp Tyr Leu 
545                 550                 555                 560 
Phe Lys Thr Arg Arg Lys Val Lys Lys Lys Asp Ile Ile Gln Phe Tyr 
                565                 570                 575     
Arg Asn Glu Tyr Asn Thr Glu Ile Val Thr Leu Ser Gly Leu Glu Glu 
            580                 585                 590         
Asp Gln Phe Asn Ala Ser Phe Ser Thr Tyr Gln Asp Leu Leu Lys Cys 
        595                 600                 605             
Gly Leu Thr Arg Ala Glu Leu Asp His Pro Asp Asn Ala Glu Lys Leu 
    610                 615                 620                 
Glu Asp Ile Ile Lys Ile Leu Thr Ile Phe Glu Asp Arg Gln Arg Ile 
625                 630                 635                 640 
Arg Thr Gln Leu Ser Thr Phe Lys Gly Gln Phe Ser Ala Glu Val Leu 
                645                 650                 655     
Lys Lys Leu Glu Arg Lys His Tyr Thr Gly Trp Gly Arg Leu Ser Lys 
            660                 665                 670         
Lys Leu Ile Asn Gly Ile Tyr Asp Lys Glu Ser Gly Lys Thr Ile Leu 
        675                 680                 685             
Asp Tyr Leu Val Lys Asp Asp Gly Val Ser Lys His Tyr Asn Arg Asn 
    690                 695                 700                 
Phe Met Gln Leu Ile Asn Asp Ser Gln Leu Ser Phe Lys Asn Ala Ile 
705                 710                 715                 720 
Gln Lys Ala Gln Ser Ser Glu His Glu Glu Thr Leu Ser Glu Thr Val 
                725                 730                 735     
Asn Glu Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile Tyr Gln Ser 
            740                 745                 750         
Leu Lys Ile Val Asp Glu Leu Val Ala Ile Met Gly Tyr Ala Pro Lys 
        755                 760                 765             
Arg Ile Val Val Glu Met Ala Arg Glu Asn Gln Thr Thr Ser Thr Gly 
    770                 775                 780                 
Lys Arg Arg Ser Ile Gln Arg Leu Lys Ile Val Glu Lys Ala Met Ala 
785                 790                 795                 800 
Glu Ile Gly Ser Asn Leu Leu Lys Glu Gln Pro Thr Thr Asn Glu Gln 
                805                 810                 815     
Leu Arg Asp Thr Arg Leu Phe Leu Tyr Tyr Met Gln Asn Gly Lys Asp 
            820                 825                 830         
Met Tyr Thr Gly Asp Glu Leu Ser Leu His Arg Leu Ser His Tyr Asp 
        835                 840                 845             
Ile Asp His Ile Ile Pro Gln Ser Phe Met Lys Asp Asp Ser Leu Asp 
    850                 855                 860                 
Asn Leu Val Leu Val Gly Ser Thr Glu Asn Arg Gly Lys Ser Asp Asp 
865                 870                 875                 880 
Val Pro Ser Lys Glu Val Val Lys Asp Met Lys Ala Tyr Trp Glu Lys 
                885                 890                 895     
Leu Tyr Ala Ala Gly Leu Ile Ser Gln Arg Lys Phe Gln Arg Leu Thr 
            900                 905                 910         
Lys Gly Glu Gln Gly Gly Leu Thr Leu Glu Asp Lys Ala His Phe Ile 
        915                 920                 925             
Gln Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys Asn Val Ala Gly 
    930                 935                 940                 
Ile Leu Asp Gln Arg Tyr Asn Ala Lys Ser Lys Glu Lys Lys Val Gln 
945                 950                 955                 960 
Ile Ile Thr Leu Lys Ala Ser Leu Thr Ser Gln Phe Arg Ser Ile Phe 
                965                 970                 975     
Gly Leu Tyr Lys Val Arg Glu Val Asn Asp Tyr His His Gly Gln Asp 
            980                 985                 990         
Ala Tyr Leu Asn Cys Val Val Ala  Thr Thr Leu Leu Lys  Val Tyr Pro 
        995                 1000                 1005             
Asn Leu  Ala Pro Glu Phe Val  Tyr Gly Glu Tyr Pro  Lys Phe Gln 
    1010                 1015                 1020             
Thr Phe  Lys Glu Asn Lys Ala  Thr Ala Lys Ala Ile  Ile Tyr Thr 
    1025                 1030                 1035             
Asn Leu  Leu Arg Phe Phe Thr  Glu Asp Glu Pro Arg  Phe Thr Lys 
    1040                 1045                 1050             
Asp Gly  Glu Ile Leu Trp Ser  Asn Ser Tyr Leu Lys  Thr Ile Lys 
    1055                 1060                 1065             
Lys Glu  Leu Asn Tyr His Gln  Met Asn Ile Val Lys  Lys Val Glu 
    1070                 1075                 1080             
Val Gln  Lys Gly Gly Phe Ser  Lys Glu Ser Ile Lys  Pro Lys Gly 
    1085                 1090                 1095             
Pro Ser  Asn Lys Leu Ile Pro  Val Lys Asn Gly Leu  Asp Pro Gln 
    1100                 1105                 1110             
Lys Tyr  Gly Gly Phe Asp Ser  Pro Ile Val Ala Tyr  Thr Val Leu 
    1115                 1120                 1125             
Phe Thr  His Glu Lys Gly Lys  Lys Pro Leu Ile Lys  Gln Glu Ile 
    1130                 1135                 1140             
Leu Gly  Ile Thr Ile Met Glu  Lys Thr Arg Phe Glu  Gln Asn Pro 
    1145                 1150                 1155             
Ile Leu  Phe Leu Glu Glu Lys  Gly Phe Leu Arg Pro  Arg Val Leu 
    1160                 1165                 1170             
Met Lys  Leu Pro Lys Tyr Thr  Leu Tyr Glu Phe Pro  Glu Gly Arg 
    1175                 1180                 1185             
Arg Arg  Leu Leu Ala Ser Ala  Lys Glu Ala Gln Lys  Gly Asn Gln 
    1190                 1195                 1200             
Met Val  Leu Pro Glu His Leu  Leu Thr Leu Leu Tyr  His Ala Lys 
    1205                 1210                 1215             
Gln Cys  Leu Leu Pro Asn Gln  Ser Glu Ser Leu Ala  Tyr Val Glu 
    1220                 1225                 1230             
Gln His  Gln Pro Glu Phe Gln  Glu Ile Leu Glu Arg  Val Val Asp 
    1235                 1240                 1245             
Phe Ala  Glu Val His Thr Leu  Ala Lys Ser Lys Val  Gln Gln Ile 
    1250                 1255                 1260             
Val Lys  Leu Phe Glu Ala Asn  Gln Thr Ala Asp Val  Lys Glu Ile 
    1265                 1270                 1275             
Ala Ala  Ser Phe Ile Gln Leu  Met Gln Phe Asn Ala  Met Gly Ala 
    1280                 1285                 1290             
Pro Ser  Thr Phe Lys Phe Phe  Gln Lys Asp Ile Glu  Arg Ala Arg 
    1295                 1300                 1305             
Tyr Thr  Ser Ile Lys Glu Ile  Phe Asp Ala Thr Ile  Ile Tyr Gln 
    1310                 1315                 1320             
Ser Thr  Thr Gly Leu Tyr Glu  Thr Arg Arg Lys Val  Val Asp 
    1325                 1330                 1335         

<210>  53
<211>  1337
<212>  PRT
<213>  Bacillus cereus

<400>  53
Met Lys Lys Asp Tyr Val Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      
Gly Trp Ala Val Met Thr Glu Asp Tyr Gln Leu Val Lys Lys Lys Met 
            20                  25                  30          
Pro Ile Tyr Gly Asn Thr Glu Lys Lys Lys Ile Lys Lys Asn Phe Trp 
        35                  40                  45              
Gly Val Arg Leu Phe Glu Glu Gly His Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  
Lys Arg Thr Ala Arg Arg Arg Ile Ser Arg Arg Arg Asn Arg Leu Arg 
65                  70                  75                  80  
Tyr Leu Gln Ala Phe Phe Glu Glu Ala Met Thr Asp Leu Asp Glu Asn 
                85                  90                  95      
Phe Phe Ala Arg Leu His Glu Ser Phe Leu Val Pro Glu Asp Lys Lys 
            100                 105                 110         
Trp His Arg His Pro Ile Phe Ala Lys Leu Glu Asp Glu Val Ala Tyr 
        115                 120                 125             
His Glu Thr Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Ala Asp 
    130                 135                 140                 
Ser Ser Glu Gln Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 
Ile Val Lys Tyr Arg Gly His Phe Leu Ile Glu Gly Lys Leu Ser Thr 
                165                 170                 175     
Glu Asn Thr Ser Val Lys Glu Gln Phe Gln Gln Phe Met Val Ile Tyr 
            180                 185                 190         
Asn Gln Thr Phe Val Asn Gly Glu Ser Arg Leu Val Ser Ala Pro Leu 
        195                 200                 205             
Pro Glu Ser Val Leu Ile Glu Glu Glu Leu Thr Glu Lys Ala Ser Arg 
    210                 215                 220                 
Thr Lys Lys Ser Glu Lys Val Leu Gln Gln Phe Pro Gln Glu Lys Ala 
225                 230                 235                 240 
Asn Gly Leu Phe Gly Gln Phe Leu Lys Leu Met Val Gly Asn Lys Ala 
                245                 250                 255     
Asp Phe Lys Lys Val Phe Ala Leu Glu Glu Glu Ala Lys Ile Thr Tyr 
            260                 265                 270         
Ala Ser Glu Ser Tyr Glu Glu Asp Leu Glu Gly Ile Leu Ala Lys Ile 
        275                 280                 285             
Gly Asp Glu Tyr Ser Asp Val Phe Leu Ala Ala Lys Asn Val Tyr Asp 
    290                 295                 300                 
Ala Val Glu Leu Ser Thr Ile Leu Ala Asp Ser Asp Lys Lys Ser His 
305                 310                 315                 320 
Ala Lys Leu Ser Ser Ser Met Ile Val Arg Phe Thr Glu His Gln Glu 
                325                 330                 335     
Asp Leu Lys Lys Phe Lys Arg Phe Ile Arg Glu Asn Cys Pro Asp Glu 
            340                 345                 350         
Tyr Asp Asn Leu Phe Lys Asn Glu Gln Lys Asp Gly Tyr Ala Gly Tyr 
        355                 360                 365             
Ile Ala His Ala Gly Lys Val Ser Gln Leu Lys Phe Tyr Gln Tyr Val 
    370                 375                 380                 
Lys Lys Ile Ile Gln Asp Ile Ala Gly Ala Glu Tyr Phe Leu Glu Lys 
385                 390                 395                 400 
Ile Ala Gln Glu Asn Phe Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly 
                405                 410                 415     
Val Ile Pro His Gln Ile His Leu Ala Glu Leu Gln Ala Ile Ile His 
            420                 425                 430         
Arg Gln Ala Ala Tyr Tyr Pro Phe Leu Lys Glu Asn Gln Glu Lys Ile 
        435                 440                 445             
Glu Gln Leu Val Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ser 
    450                 455                 460                 
Lys Gly Asp Ala Ser Thr Phe Ala Trp Leu Lys Arg Gln Asn Glu Lys 
465                 470                 475                 480 
Pro Ile Arg Pro Trp Asn Leu Gln Glu Thr Val Asp Leu Asp Gln Ser 
                485                 490                 495     
Ala Thr Ala Phe Ile Glu Arg Met Thr Asn Phe Asp Thr Tyr Leu Pro 
            500                 505                 510         
Ser Glu Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu Lys Phe Met 
        515                 520                 525             
Val Phe Asn Glu Leu Thr Lys Ile Ser Tyr Thr Asp Asp Arg Gly Ile 
    530                 535                 540                 
Lys Ala Asn Phe Ser Gly Lys Glu Lys Glu Lys Ile Phe Asp Tyr Leu 
545                 550                 555                 560 
Phe Lys Thr Arg Arg Lys Val Lys Lys Lys Asp Ile Ile Gln Phe Tyr 
                565                 570                 575     
Arg Asn Glu Tyr Asn Thr Glu Ile Val Thr Leu Ser Gly Leu Glu Glu 
            580                 585                 590         
Asp Gln Phe Asn Ala Ser Phe Ser Thr Tyr Gln Asp Leu Leu Lys Cys 
        595                 600                 605             
Gly Leu Thr Arg Ala Glu Leu Asp His Pro Asp Asn Ala Glu Lys Leu 
    610                 615                 620                 
Glu Asp Ile Ile Lys Ile Leu Thr Ile Phe Glu Asp Arg Gln Arg Ile 
625                 630                 635                 640 
Arg Thr Gln Leu Ser Thr Phe Lys Gly Gln Phe Ser Ala Glu Val Leu 
                645                 650                 655     
Lys Lys Leu Glu Arg Lys His Tyr Thr Gly Trp Gly Arg Leu Ser Lys 
            660                 665                 670         
Lys Leu Ile Asn Gly Ile Tyr Asp Lys Glu Ser Gly Lys Thr Ile Leu 
        675                 680                 685             
Asp Tyr Leu Val Lys Asp Asp Gly Val Ser Lys His Tyr Asn Arg Asn 
    690                 695                 700                 
Phe Met Gln Leu Ile Asn Asp Ser Gln Leu Ser Phe Lys Asn Ala Ile 
705                 710                 715                 720 
Gln Lys Ala Gln Ser Ser Glu His Glu Glu Thr Leu Ser Glu Thr Val 
                725                 730                 735     
Asn Glu Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile Tyr Gln Ser 
            740                 745                 750         
Leu Lys Ile Val Asp Glu Leu Val Ala Ile Met Gly Tyr Ala Pro Lys 
        755                 760                 765             
Arg Ile Val Val Glu Met Ala Arg Glu Asn Gln Thr Thr Ser Thr Gly 
    770                 775                 780                 
Lys Arg Arg Ser Ile Gln Arg Leu Lys Ile Val Glu Lys Ala Met Ala 
785                 790                 795                 800 
Glu Ile Gly Ser Asn Leu Leu Lys Glu Gln Pro Thr Thr Asn Glu Gln 
                805                 810                 815     
Leu Arg Asp Thr Arg Leu Phe Leu Tyr Tyr Met Gln Asn Gly Lys Asp 
            820                 825                 830         
Met Tyr Thr Gly Asp Glu Leu Ser Leu His Arg Leu Ser His Tyr Asp 
        835                 840                 845             
Ile Asp His Ile Ile Pro Gln Ser Phe Met Lys Asp Asp Ser Leu Asp 
    850                 855                 860                 
Asn Leu Val Leu Val Gly Ser Thr Glu Asn Arg Gly Lys Ser Asp Asp 
865                 870                 875                 880 
Val Pro Ser Lys Glu Val Val Lys Asp Met Lys Ala Tyr Trp Glu Lys 
                885                 890                 895     
Leu Tyr Ala Ala Gly Leu Ile Ser Gln Arg Lys Phe Gln Arg Leu Thr 
            900                 905                 910         
Lys Gly Glu Gln Gly Gly Leu Thr Leu Glu Asp Lys Ala His Phe Ile 
        915                 920                 925             
Gln Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys Asn Val Ala Gly 
    930                 935                 940                 
Ile Leu Asp Gln Arg Tyr Asn Ala Lys Ser Lys Glu Lys Lys Val Gln 
945                 950                 955                 960 
Ile Ile Thr Leu Lys Ala Ser Leu Thr Ser Gln Phe Arg Ser Ile Phe 
                965                 970                 975     
Gly Leu Tyr Lys Val Arg Glu Val Asn Asp Tyr His His Gly Gln Asp 
            980                 985                 990         
Ala Tyr Leu Asn Cys Val Val Ala  Thr Thr Leu Leu Lys  Val Cys Pro 
        995                 1000                 1005             
Asn Leu  Ala Pro Glu Phe Val  Tyr Gly Glu Tyr Pro  Lys Phe Gln 
    1010                 1015                 1020             
Thr Phe  Lys Glu Asn Lys Ala  Thr Ala Lys Ala Ile  Ile Tyr Thr 
    1025                 1030                 1035             
Asn Leu  Leu Arg Phe Phe Thr  Glu Asp Glu Pro Arg  Phe Thr Lys 
    1040                 1045                 1050             
Asp Gly  Glu Ile Leu Trp Ser  Asn Ser Tyr Leu Lys  Thr Ile Lys 
    1055                 1060                 1065             
Lys Glu  Leu Asn Tyr His Gln  Met Asn Ile Val Lys  Lys Val Glu 
    1070                 1075                 1080             
Val Gln  Lys Gly Gly Phe Ser  Lys Glu Ser Ile Lys  Pro Lys Gly 
    1085                 1090                 1095             
Pro Ser  Asn Lys Leu Ile Pro  Val Lys Asn Gly Leu  Asp Pro Gln 
    1100                 1105                 1110             
Lys Tyr  Gly Gly Phe Asp Ser  Pro Val Val Ala Tyr  Thr Val Leu 
    1115                 1120                 1125             
Phe Thr  His Glu Lys Gly Lys  Lys Pro Leu Ile Lys  Gln Glu Ile 
    1130                 1135                 1140             
Leu Gly  Ile Thr Ile Met Glu  Lys Thr Arg Phe Glu  Gln Asn Pro 
    1145                 1150                 1155             
Ile Leu  Phe Leu Glu Glu Lys  Gly Phe Leu Arg Pro  Arg Val Leu 
    1160                 1165                 1170             
Met Lys  Leu Pro Lys Tyr Thr  Leu Tyr Glu Phe Pro  Glu Gly Arg 
    1175                 1180                 1185             
Arg Arg  Leu Leu Ala Ser Ala  Lys Glu Ala Gln Lys  Gly Asn Gln 
    1190                 1195                 1200             
Met Val  Leu Pro Glu His Leu  Leu Thr Leu Leu Tyr  His Ala Lys 
    1205                 1210                 1215             
Gln Cys  Leu Leu Pro Asn Gln  Ser Glu Ser Leu Ala  Tyr Val Glu 
    1220                 1225                 1230             
Gln His  Gln Pro Glu Phe Gln  Glu Ile Leu Glu Arg  Val Val Asp 
    1235                 1240                 1245             
Phe Ala  Glu Val His Thr Leu  Ala Lys Ser Lys Val  Gln Gln Ile 
    1250                 1255                 1260             
Val Lys  Leu Phe Glu Ala Asn  Gln Thr Ala Asp Val  Lys Glu Ile 
    1265                 1270                 1275             
Ala Ala  Ser Phe Ile Gln Leu  Met Gln Phe Asn Ala  Met Gly Ala 
    1280                 1285                 1290             
Pro Ser  Thr Phe Lys Phe Phe  Gln Lys Asp Ile Glu  Arg Ala Arg 
    1295                 1300                 1305             
Tyr Thr  Ser Ile Lys Glu Ile  Phe Asp Ala Thr Ile  Ile Tyr Gln 
    1310                 1315                 1320             
Ser Thr  Thr Gly Leu Tyr Glu  Thr Arg Arg Lys Val  Val Asp 
    1325                 1330                 1335         

<210>  54
<211>  1337
<212>  PRT
<213>  Enterococcus faecalis

<400>  54
Met Lys Lys Asp Tyr Val Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      
Gly Trp Ala Val Met Thr Glu Asp Tyr Gln Leu Val Lys Lys Lys Met 
            20                  25                  30          
Pro Ile Tyr Gly Asn Thr Glu Lys Lys Lys Ile Lys Lys Asn Phe Trp 
        35                  40                  45              
Gly Val Arg Leu Phe Glu Glu Gly His Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  
Lys Arg Thr Ala Arg Arg Arg Ile Ser Arg Arg Arg Asn Arg Leu Arg 
65                  70                  75                  80  
Tyr Leu Gln Ala Phe Phe Glu Glu Ala Met Thr Asp Leu Asp Glu Asn 
                85                  90                  95      
Phe Phe Ala Arg Leu Gln Glu Ser Phe Leu Val Pro Glu Asp Lys Lys 
            100                 105                 110         
Trp His Arg His Pro Ile Phe Ala Lys Leu Glu Asp Glu Val Ala Tyr 
        115                 120                 125             
His Glu Thr Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Ala Asp 
    130                 135                 140                 
Ser Ser Glu Gln Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 
Ile Val Lys Tyr Arg Gly His Phe Leu Ile Glu Gly Lys Leu Ser Thr 
                165                 170                 175     
Glu Asn Thr Ser Val Lys Glu Gln Phe Gln Gln Phe Met Val Ile Tyr 
            180                 185                 190         
Asn Gln Thr Phe Val Asn Gly Glu Ser Arg Leu Val Ser Ala Pro Leu 
        195                 200                 205             
Pro Glu Ser Val Leu Ile Glu Glu Glu Leu Thr Glu Lys Ala Ser Arg 
    210                 215                 220                 
Thr Lys Lys Ser Glu Lys Val Leu Gln Gln Phe Pro Gln Glu Lys Ala 
225                 230                 235                 240 
Asn Gly Leu Phe Gly Gln Phe Leu Lys Leu Met Val Gly Asn Lys Ala 
                245                 250                 255     
Asp Phe Lys Lys Val Phe Gly Leu Glu Glu Glu Ala Lys Ile Thr Tyr 
            260                 265                 270         
Ala Ser Glu Ser Tyr Glu Glu Asp Leu Glu Gly Ile Leu Ala Lys Val 
        275                 280                 285             
Gly Asp Glu Tyr Ser Asp Val Phe Leu Ala Ala Lys Asn Val Tyr Asp 
    290                 295                 300                 
Ala Val Glu Leu Ser Thr Ile Leu Ala Asp Ser Asp Lys Lys Ser His 
305                 310                 315                 320 
Ala Lys Leu Ser Ser Ser Met Ile Val Arg Phe Thr Glu His Gln Glu 
                325                 330                 335     
Asp Leu Lys Lys Phe Lys Arg Phe Ile Arg Glu Asn Cys Pro Asp Glu 
            340                 345                 350         
Tyr Asp Asn Leu Phe Lys Asn Glu Gln Lys Asp Gly Tyr Ala Gly Tyr 
        355                 360                 365             
Ile Ala His Ala Gly Lys Val Ser Gln Leu Lys Phe Tyr Gln Tyr Val 
    370                 375                 380                 
Lys Lys Ile Ile Gln Asp Ile Ala Gly Ala Glu Tyr Phe Leu Glu Lys 
385                 390                 395                 400 
Ile Ala Gln Glu Asn Phe Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly 
                405                 410                 415     
Val Ile Pro His Gln Ile His Leu Ala Glu Leu Gln Ala Ile Ile His 
            420                 425                 430         
Arg Gln Ala Ala Tyr Tyr Pro Phe Leu Lys Glu Asn Gln Glu Lys Ile 
        435                 440                 445             
Glu Gln Leu Val Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ser 
    450                 455                 460                 
Lys Gly Asp Ala Ser Thr Phe Ala Trp Leu Lys Arg Gln Ser Glu Glu 
465                 470                 475                 480 
Pro Ile Arg Pro Trp Asn Leu Gln Glu Thr Val Asp Leu Asp Gln Ser 
                485                 490                 495     
Ala Thr Ala Phe Ile Glu Arg Met Thr Asn Phe Asp Thr Tyr Leu Pro 
            500                 505                 510         
Ser Glu Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu Lys Phe Met 
        515                 520                 525             
Val Phe Asn Glu Leu Thr Lys Ile Ser Tyr Thr Asp Asp Arg Gly Ile 
    530                 535                 540                 
Lys Ala Asn Phe Ser Gly Lys Glu Lys Glu Lys Ile Phe Asp Tyr Leu 
545                 550                 555                 560 
Phe Lys Thr Arg Arg Lys Val Lys Lys Lys Asp Ile Ile Gln Phe Tyr 
                565                 570                 575     
Arg Asn Glu Tyr Asn Thr Glu Ile Val Thr Leu Ser Gly Leu Glu Glu 
            580                 585                 590         
Asp Gln Phe Asn Ala Ser Phe Ser Thr Tyr Gln Asp Leu Leu Lys Cys 
        595                 600                 605             
Gly Leu Thr Arg Ala Glu Leu Asp His Pro Asp Asn Ala Glu Lys Leu 
    610                 615                 620                 
Glu Asp Ile Ile Lys Ile Leu Thr Ile Phe Glu Asp Arg Gln Arg Ile 
625                 630                 635                 640 
Arg Thr Gln Leu Ser Thr Phe Lys Gly Gln Phe Ser Ala Glu Val Leu 
                645                 650                 655     
Lys Lys Leu Glu Arg Lys His Tyr Thr Gly Trp Gly Arg Leu Ser Lys 
            660                 665                 670         
Lys Leu Ile Asn Gly Ile Tyr Asp Lys Glu Ser Gly Lys Thr Ile Leu 
        675                 680                 685             
Asp Tyr Leu Val Lys Asp Asp Gly Val Ser Lys His Tyr Asn Arg Asn 
    690                 695                 700                 
Phe Met Gln Leu Ile Asn Asp Ser Gln Leu Ser Phe Lys Asn Ala Ile 
705                 710                 715                 720 
Gln Lys Ala Gln Ser Ser Glu His Glu Glu Thr Leu Ser Glu Thr Val 
                725                 730                 735     
Asn Glu Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile Tyr Gln Ser 
            740                 745                 750         
Leu Lys Ile Val Asp Glu Leu Val Ala Ile Met Gly Tyr Ala Pro Lys 
        755                 760                 765             
Arg Ile Val Val Glu Met Ala Arg Glu Asn Gln Thr Thr Ser Thr Gly 
    770                 775                 780                 
Lys Arg Arg Ser Ile Gln Arg Leu Lys Ile Val Glu Lys Ala Met Ala 
785                 790                 795                 800 
Glu Ile Gly Ser Asn Leu Leu Lys Glu Gln Pro Thr Thr Asn Glu Gln 
                805                 810                 815     
Leu Arg Asp Thr Arg Leu Phe Leu Tyr Tyr Met Gln Asn Gly Lys Asp 
            820                 825                 830         
Met Tyr Thr Gly Asp Glu Leu Ser Leu His Arg Leu Ser His Tyr Asp 
        835                 840                 845             
Ile Asp His Ile Ile Pro Gln Ser Phe Met Lys Asp Asp Ser Leu Asp 
    850                 855                 860                 
Asn Leu Val Leu Val Gly Ser Thr Glu Asn Arg Gly Lys Ser Asp Asp 
865                 870                 875                 880 
Val Pro Ser Lys Lys Val Val Lys Lys Met Lys Ala Tyr Trp Glu Lys 
                885                 890                 895     
Leu Tyr Ala Ala Gly Leu Ile Ser Gln Arg Lys Phe Gln Arg Leu Thr 
            900                 905                 910         
Lys Gly Glu Gln Gly Gly Leu Thr Leu Glu Asp Lys Ala His Phe Ile 
        915                 920                 925             
Gln Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys Asn Val Ala Gly 
    930                 935                 940                 
Ile Leu Asp Gln Arg Tyr Asn Ala Lys Ser Lys Glu Lys Lys Val Gln 
945                 950                 955                 960 
Ile Ile Thr Leu Lys Ala Ser Leu Thr Ser Gln Phe Arg Ser Ile Phe 
                965                 970                 975     
Gly Leu Tyr Lys Val Arg Glu Val Asn Asp Tyr His His Gly Gln Asp 
            980                 985                 990         
Ala Tyr Leu Asn Cys Val Val Ala  Thr Thr Leu Leu Lys  Val Tyr Pro 
        995                 1000                 1005             
Asn Leu  Ala Pro Glu Phe Val  Tyr Gly Glu Tyr Pro  Lys Phe Gln 
    1010                 1015                 1020             
Ala Phe  Lys Glu Asn Lys Ala  Thr Ala Lys Thr Ile  Ile Tyr Thr 
    1025                 1030                 1035             
Asn Leu  Met Arg Phe Phe Thr  Glu Asp Glu Pro Arg  Phe Thr Lys 
    1040                 1045                 1050             
Asp Ser  Glu Ile Leu Trp Ser  Asn Ser Tyr Leu Lys  Thr Ile Lys 
    1055                 1060                 1065             
Lys Glu  Leu Asn Tyr His Gln  Met Asn Ile Val Lys  Lys Val Glu 
    1070                 1075                 1080             
Val Gln  Lys Gly Gly Phe Ser  Lys Glu Ser Ile Lys  Pro Lys Gly 
    1085                 1090                 1095             
Pro Ser  Asn Lys Leu Ile Pro  Val Lys Asn Gly Leu  Asp Pro Gln 
    1100                 1105                 1110             
Lys Tyr  Gly Gly Phe Asp Ser  Pro Val Val Ala Tyr  Thr Val Leu 
    1115                 1120                 1125             
Phe Thr  His Glu Lys Gly Lys  Lys Pro Leu Ile Lys  Gln Glu Ile 
    1130                 1135                 1140             
Leu Gly  Ile Thr Ile Met Glu  Lys Thr Arg Phe Glu  Gln Asn Pro 
    1145                 1150                 1155             
Ile Leu  Phe Leu Glu Glu Lys  Gly Phe Leu Arg Pro  Arg Val Leu 
    1160                 1165                 1170             
Met Lys  Leu Pro Lys Tyr Thr  Leu Tyr Glu Phe Pro  Glu Gly Arg 
    1175                 1180                 1185             
Arg Arg  Leu Leu Ala Ser Ala  Lys Glu Ala Gln Lys  Gly Asn Gln 
    1190                 1195                 1200             
Met Val  Leu Pro Glu His Leu  Leu Thr Leu Leu Tyr  His Ala Lys 
    1205                 1210                 1215             
Gln Cys  Leu Leu Pro Asn Gln  Ser Glu Ser Leu Ala  Tyr Val Glu 
    1220                 1225                 1230             
Gln His  Gln Pro Glu Phe Gln  Glu Ile Leu Glu Arg  Val Val Asp 
    1235                 1240                 1245             
Phe Ala  Glu Val His Thr Leu  Ala Lys Ser Lys Val  Gln Gln Ile 
    1250                 1255                 1260             
Val Lys  Leu Phe Glu Ala Asn  Gln Thr Ala Asp Val  Lys Glu Ile 
    1265                 1270                 1275             
Ala Ala  Ser Phe Ile Gln Leu  Met Gln Phe Asn Ala  Met Gly Ala 
    1280                 1285                 1290             
Pro Ser  Thr Phe Lys Phe Phe  Gln Lys Asp Ile Glu  Arg Ala Arg 
    1295                 1300                 1305             
Tyr Thr  Ser Ile Lys Glu Ile  Phe Asp Ala Thr Ile  Ile Tyr Gln 
    1310                 1315                 1320             
Ser Thr  Thr Gly Leu Tyr Glu  Thr Arg Arg Lys Val  Val Asp 
    1325                 1330                 1335         

<210>  55
<211>  1330
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Cas-Locus 14

<400>  55
Met Glu Lys Glu Tyr Thr Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      
Gly Trp Ala Val Leu Thr Asp Asp Tyr Arg Leu Val Ala Arg Lys Met 
            20                  25                  30          
Ser Ile Gln Gly Asp Ser Asn Arg Lys Lys Ile Lys Lys Asn Phe Trp 
        35                  40                  45              
Gly Ala Arg Leu Phe Glu Glu Gly Lys Thr Ala Gln Phe Arg Arg Ile 
    50                  55                  60                  
Lys Arg Thr Asn Arg Arg Arg Ile Ala Arg Arg Arg Gln Arg Val Leu 
65                  70                  75                  80  
Ala Leu Gln Asp Ile Phe Ala Glu Glu Ile His Lys Lys Asp Pro Asn 
                85                  90                  95      
Phe Phe Ala Arg Leu Glu Glu Gly Asp Arg Val Glu Ala Asp Lys Arg 
            100                 105                 110         
Phe Ala Lys Phe Pro Val Phe Ala Thr Leu Ser Glu Glu Lys Asn Tyr 
        115                 120                 125             
His Arg Gln Tyr Pro Thr Ile Tyr His Leu Arg His Asp Leu Ala Asn 
    130                 135                 140                 
Ser Lys Glu Gln Ala Asp Ile Arg Leu Val Tyr Leu Ala Ile Ala His 
145                 150                 155                 160 
Cys Leu Lys Tyr Arg Gly His Phe Leu Phe Glu Gly Glu Leu Asp Thr 
                165                 170                 175     
Glu Asn Thr Ser Val Thr Glu Asn Tyr Gln Gln Phe Leu Gln Ala Tyr 
            180                 185                 190         
Gln Gln Phe Phe Pro Glu Pro Ile Gly Asp Leu Asp Asp Ala Val Pro 
        195                 200                 205             
Ile Leu Thr Glu Arg Leu Ser Lys Ala Lys Arg Val Glu Lys Val Leu 
    210                 215                 220                 
Ala Tyr Tyr Pro Ser Glu Lys Ser Thr Gly Asn Phe Ala Gln Phe Leu 
225                 230                 235                 240 
Lys Leu Met Val Gly Asn Gln Ala Asn Phe Lys Lys Thr Phe Asp Leu 
                245                 250                 255     
Glu Glu Glu Met Lys Leu Asn Phe Thr Arg Asp Cys Tyr Glu Glu Asp 
            260                 265                 270         
Leu Asn Glu Leu Leu Glu Lys Thr Ser Asp Asp Tyr Ala Glu Leu Phe 
        275                 280                 285             
Leu Lys Ala Lys Gly Val Tyr Asp Ala Ile Leu Leu Ser Gln Ile Leu 
    290                 295                 300                 
Ser Lys Ser Asp Asp Glu Thr Lys Ala Lys Leu Ser Ala Asn Met Lys 
305                 310                 315                 320 
Leu Arg Phe Glu Glu His Gln Arg Asp Leu Lys Gln Leu Lys Glu Leu 
                325                 330                 335     
Val Arg Arg Asp Leu Pro Lys Lys Tyr Asp Asp Phe Phe Lys Asn Arg 
            340                 345                 350         
Ser Lys Asn Gly Tyr Ala Gly Tyr Val Lys Gly Lys Ala Thr Gln Glu 
        355                 360                 365             
Asp Phe Tyr Lys Phe Leu Arg Thr Glu Leu Ala Gly Leu Glu Glu Ser 
    370                 375                 380                 
Gln Ser Ile Met Glu Lys Ile Asp Leu Glu Ile Tyr Leu Leu Lys Gln 
385                 390                 395                 400 
Arg Thr Phe Ala Asn Gly Val Ile Pro His Gln Ile His Leu Val Glu 
                405                 410                 415     
Met Arg Glu Ile Met Asp Arg Gln Lys Arg Phe Tyr Pro Phe Leu Lys 
            420                 425                 430         
Gly Ala Gln Gly Lys Ile Glu Lys Leu Leu Thr Phe Arg Ile Pro Tyr 
        435                 440                 445             
Tyr Val Gly Pro Leu Ala Gln Glu Gly Gln Ser Pro Phe Ala Trp Ile 
    450                 455                 460                 
Lys Arg Lys Ser Pro Ser Gln Ile Thr Pro Trp Asn Phe Ala Glu Val 
465                 470                 475                 480 
Val Asp Lys Glu Asn Ser Ala Ile Glu Phe Ile Glu Arg Met Thr Asn 
                485                 490                 495     
Gln Asp Thr Tyr Leu Pro Lys Glu Lys Val Leu Pro Lys Gln Ser Leu 
            500                 505                 510         
Ile Tyr Gln Arg Phe Met Ile Phe Asn Glu Leu Thr Lys Val Ser Tyr 
        515                 520                 525             
Thr Asp Glu Arg Gly Lys Ser His Tyr Phe Ser Ser Glu Gln Lys Arg 
    530                 535                 540                 
Lys Ile Phe Asn Glu Leu Phe Lys Gln His Pro Arg Val Thr Glu Lys 
545                 550                 555                 560 
Gln Leu Arg Lys Phe Leu Glu Leu Asn Glu Gln Ile Asp Ser Thr Glu 
                565                 570                 575     
Ile Lys Gly Ile Glu Thr Ser Phe Asn Ala Ser Tyr Ser Thr Tyr His 
            580                 585                 590         
Asp Leu Leu Lys Leu Ser Asp Gln Met Asp Thr Leu Leu Asp Asp Pro 
        595                 600                 605             
Asp Met Thr Thr Met Phe Glu Glu Ile Ile Lys Ile Leu Thr Ile Phe 
    610                 615                 620                 
Glu Asp Arg Glu Met Ile Arg Glu Gln Leu Lys Pro Tyr Glu Thr Val 
625                 630                 635                 640 
Leu Gly Leu Pro Ala Ile Lys Lys Leu Ala Lys Lys His Tyr Thr Gly 
                645                 650                 655     
Trp Gly Arg Leu Ser Glu Lys Met Ile Gln Gly Met Arg Glu Lys Gln 
            660                 665                 670         
Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Asp Asp Phe Pro 
        675                 680                 685             
Cys Asn Arg Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp His Leu 
    690                 695                 700                 
Ser Phe Lys Glu Thr Ile Ala Asn Glu Leu Ile Met Ser Asp Ser Asn 
705                 710                 715                 720 
Val Leu Leu Asp Gln Val Lys Ala Ile Pro Gly Ser Pro Ala Val Lys 
                725                 730                 735     
Lys Gly Ile Trp Gln Ser Ile Lys Ile Val Glu Glu Ile Ile Gly Ile 
            740                 745                 750         
Ile Gly Lys Ala Pro Lys Asn Ile Val Ile Glu Met Ala Arg Glu Asn 
        755                 760                 765             
Gln Arg Thr Ser Arg Ser Arg Pro Arg Leu Lys Ala Leu Glu Glu Ala 
    770                 775                 780                 
Leu Lys Asn Ile Asp Ser Pro Leu Leu Lys Asp Tyr Pro Thr Asp Asn 
785                 790                 795                 800 
Gln Ala Leu Gln Lys Asp Arg Leu Tyr Leu Tyr Tyr Leu Gln Asn Gly 
                805                 810                 815     
Lys Asp Met Tyr Thr Gly Glu Pro Leu Glu Ile His Arg Leu Ser Glu 
            820                 825                 830         
Tyr Asp Ile Asp His Ile Ile Pro Arg Ser Phe Ile Val Asp Asn Ser 
        835                 840                 845             
Leu Asp Asn Lys Val Leu Val Ser Ser Lys Val Asn Arg Gly Lys Leu 
    850                 855                 860                 
Asp Asn Ala Pro Asp Pro Leu Val Val Lys Arg Met Arg Ser His Trp 
865                 870                 875                 880 
Glu Lys Leu His Gln Ala Lys Leu Ile Ser Asp Lys Lys Leu Ala Asn 
                885                 890                 895     
Leu Thr Lys Gln Asn Leu Thr Glu Ala Asp Lys Ala Arg Phe Ile Gln 
            900                 905                 910         
Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys His Val Ala Asn Leu 
        915                 920                 925             
Leu His Gln His Phe Asn Leu Pro Glu Glu Val Ser Ala Thr Glu Lys 
    930                 935                 940                 
Thr Ser Ile Ile Thr Leu Lys Ser Thr Leu Thr Ser Gln Phe Arg Gln 
945                 950                 955                 960 
Met Phe Asp Ile Tyr Lys Val Arg Glu Ile Asn His His His His Ala 
                965                 970                 975     
His Asp Ala Tyr Leu Asn Gly Val Val Ala Met Thr Leu Leu Lys Lys 
            980                 985                 990         
Tyr Pro Lys Leu Ala Pro Glu Phe  Val Tyr Gly Ser Tyr  Ile Lys Gly 
        995                 1000                 1005             
Asp Ile  Asn Gln Ile Asn Lys  Ala Thr Ala Lys Lys  Glu Phe Tyr 
    1010                 1015                 1020             
Ser Asn  Ile Met Lys Phe Phe  Glu Ser Glu Glu Ile  Ile Cys Asp 
    1025                 1030                 1035             
Glu Gln  Gly Glu Val Ile Trp  Asn Lys Lys Arg Asp  Leu Ser Thr 
    1040                 1045                 1050             
Ile Lys  Lys Thr Ile Gly Ala  His Gln Val Asn Ile  Val Lys Lys 
    1055                 1060                 1065             
Val Glu  Lys Gln Lys Gly Gly  Phe Tyr Lys Glu Thr  Ile Asn Ser 
    1070                 1075                 1080             
Lys Ala  Asn Pro Glu Lys Leu  Ile Pro Arg Lys Ala  Ser Leu Asp 
    1085                 1090                 1095             
Pro Leu  Lys Tyr Gly Gly Tyr  Gly Ser Pro Leu Val  Ala Tyr Thr 
    1100                 1105                 1110             
Val Ile  Phe Ile Phe Glu Lys  Gly Lys Gln Lys Lys  Val Thr Lys 
    1115                 1120                 1125             
Gly Ile  Glu Gly Ile Thr Val  Met Glu Gln Leu Arg  Phe Glu Gln 
    1130                 1135                 1140             
Asp Pro  Arg Glu Phe Leu Lys  Thr Lys Gly Tyr Glu  Gly Val Lys 
    1145                 1150                 1155             
Gln Trp  Leu Ile Leu Pro Lys  Tyr Ile Leu Phe Glu  Ala Gln Gly 
    1160                 1165                 1170             
Gly Tyr  Arg Arg Met Ile Ala  Ser His Gln Glu Thr  Gln Lys Ala 
    1175                 1180                 1185             
Asn Ser  Leu Ile Leu Pro Glu  Asn Leu Val Thr Leu  Leu Tyr His 
    1190                 1195                 1200             
Ala Arg  His Tyr Asp Glu Ile  Asn His Lys Val Ser  Phe Asp Tyr 
    1205                 1210                 1215             
Val Asn  Ala His Lys Glu Gly  Phe Asn Asp Ile Phe  Asp Phe Ile 
    1220                 1225                 1230             
Ser Asp  Phe Gly Val Arg Tyr  Ile Leu Ala Pro Gln  His Leu Glu 
    1235                 1240                 1245             
Lys Ile  Lys Val Ala Tyr Glu  Lys Asn Lys Glu Val  Asp Leu Lys 
    1250                 1255                 1260             
Glu Met  Ile Asp Ala Ile Leu  Ser Leu Leu Lys Phe  Thr Leu Phe 
    1265                 1270                 1275             
Gly Ala  Ser Val Glu Phe Lys  Phe Phe Asp Ile Lys  Ile Leu Lys 
    1280                 1285                 1290             
Arg Tyr  Lys Ser Leu Thr Asp  Ile Trp Glu Ala Thr  Ile Ile Tyr 
    1295                 1300                 1305             
Gln Ser  Val Thr Gly Leu Tyr  Glu Arg Arg Val Glu  Val Arg Lys 
    1310                 1315                 1320             
Leu Trp  Asp Gly Glu Arg Leu  
    1325                 1330 

<210>  56
<211>  1150
<212>  PRT
<213>  Enterococcus faecalis

<400>  56
Met Tyr Ser Ile Gly Leu Asp Leu Gly Ile Ser Ser Val Gly Trp Ser 
1               5                   10                  15      
Val Ile Asp Glu Arg Thr Gly Asn Val Ile Asp Leu Gly Val Arg Leu 
            20                  25                  30          
Phe Ser Ala Lys Asn Ser Glu Lys Asn Leu Glu Arg Arg Thr Asn Arg 
        35                  40                  45              
Gly Gly Arg Arg Leu Ile Arg Arg Lys Thr Asn Arg Leu Lys Asp Ala 
    50                  55                  60                  
Lys Lys Ile Leu Ala Ala Val Gly Phe Tyr Glu Asp Lys Ser Leu Lys 
65                  70                  75                  80  
Asn Ser Cys Pro Tyr Gln Leu Arg Val Lys Gly Leu Thr Glu Pro Leu 
                85                  90                  95      
Ser Lys Gly Glu Ile Tyr Lys Val Thr Leu His Ile Leu Lys Lys Arg 
            100                 105                 110         
Gly Ile Ser Tyr Leu Asp Glu Asp Asp Thr Glu Ala Ala Lys Glu Ser 
        115                 120                 125             
Gln Asp Tyr Lys Glu Gln Val Arg Glu Asn Ala Gln Leu Leu Thr Lys 
    130                 135                 140                 
Tyr Thr Pro Gly Gln Ile Gln Leu Gln Arg Leu Lys Glu Asn Asn Arg 
145                 150                 155                 160 
Val Lys Thr Gly Ile Asn Ala Gln Gly Asn Tyr Gln Leu Asn Val Phe 
                165                 170                 175     
Lys Val Ser Ala Tyr Ala Asn Glu Leu Ala Thr Ile Leu Lys Thr Gln 
            180                 185                 190         
Gln Ala Phe Tyr Pro Asn Glu Leu Thr Asp Asp Trp Ile Ala Leu Phe 
        195                 200                 205             
Val Gln Pro Gly Ile Ala Glu Glu Ala Gly Leu Ile Tyr Arg Lys Arg 
    210                 215                 220                 
Pro Tyr Tyr His Gly Pro Gly Asn Glu Ala Asn Asn Ser Pro Tyr Gly 
225                 230                 235                 240 
Arg Trp Ser Asp Phe Lys Lys Thr Gly Gln Pro Ala Thr Asn Ile Phe 
                245                 250                 255     
Asp Lys Leu Ile Gly Lys Asp Phe Gln Gly Glu Leu Arg Ala Ser Gly 
            260                 265                 270         
Leu Ser Leu Ser Ala Gln Gln Tyr Asn Leu Leu Asn Asp Leu Thr Asn 
        275                 280                 285             
Leu Lys Ile Asp Gly Glu Ile Pro Leu Ser Leu Glu Gln Lys Glu Tyr 
    290                 295                 300                 
Ile Leu Ala Glu Leu Met Thr Lys Glu Phe Thr Arg Phe Gly Val Asn 
305                 310                 315                 320 
Asp Val Val Lys Leu Leu Gly Val Lys Lys Glu Arg Leu Ser Gly Trp 
                325                 330                 335     
Arg Leu Asp Lys Lys Gly Lys Pro Glu Ile His Thr Leu Lys Ala Tyr 
            340                 345                 350         
Arg Asn Trp Arg Lys Ile Phe Ala Glu Ala Gly Ile Asp Leu Ala Thr 
        355                 360                 365             
Leu Pro Thr Glu Thr Ile Asp Cys Leu Ala Lys Val Leu Thr Leu Asn 
    370                 375                 380                 
Thr Glu Arg Glu Gly Ile Glu Asn Thr Leu Ala Phe Glu Leu Pro Lys 
385                 390                 395                 400 
Leu Ala Glu Pro Val Lys Ser Leu Val Leu Asp His Tyr Lys Glu Leu 
                405                 410                 415     
Ser Gln Ser Ile Ser Thr Gln Ala Trp His Arg Phe Ser Leu Lys Thr 
            420                 425                 430         
Leu His Leu Leu Ile Pro Glu Leu Met Asn Ala Thr Ser Glu Gln Asn 
        435                 440                 445             
Thr Leu Leu Glu Gln Phe Gln Leu Lys Ser Gly Val Arg Thr Arg Tyr 
    450                 455                 460                 
Ser Glu Tyr Asn Lys Leu Pro Thr Lys Asp Val Leu Ala Glu Ile Tyr 
465                 470                 475                 480 
Asn Pro Thr Val Asn Lys Thr Val Ser Gln Ala Phe Lys Val Met Asp 
                485                 490                 495     
Ala Leu Leu Glu Lys Tyr Gly Lys Glu Gln Ile Arg Tyr Ile Thr Ile 
            500                 505                 510         
Glu Met Pro Arg Asp Asp Asn Glu Glu Asp Glu Lys Lys Arg Ile Lys 
        515                 520                 525             
Glu Leu His Ala Lys Asn Ser Gln Arg Lys Asn Asp Ser Gln Ser Tyr 
    530                 535                 540                 
Phe Met Gln Lys Ser Gly Trp Ser Gln Glu Lys Phe Gln Thr Thr Ile 
545                 550                 555                 560 
Gln Lys Asn Arg Arg Phe Leu Ala Lys Leu Leu Tyr Tyr Tyr Glu Gln 
                565                 570                 575     
Asp Gly Ile Cys Ala Tyr Thr Gly Leu Ser Ile Ser Pro Glu Leu Leu 
            580                 585                 590         
Val Ser Asp Ser Thr Glu Ile Asp His Ile Ile Pro Ile Ser Ile Ser 
        595                 600                 605             
Leu Asp Asp Ser Ile Asn Asn Lys Val Leu Val Leu Ser Lys Ala Asn 
    610                 615                 620                 
Gln Val Lys Gly Gln Gln Thr Pro Tyr Asp Ala Trp Met Asp Gly Ser 
625                 630                 635                 640 
Phe Lys Lys Thr Asn Gly Lys Phe Ser Asn Trp Asp Asp Tyr Gln Lys 
                645                 650                 655     
Trp Val Glu Ser Arg His Phe Ser His Lys Lys Glu Asn Asn Leu Leu 
            660                 665                 670         
Glu Thr Arg Asn Ile Phe Asp Ser Glu Gln Val Glu Lys Phe Leu Ala 
        675                 680                 685             
Arg Asn Leu Asn Asp Thr Arg Tyr Ala Ser Arg Leu Val Leu Asn Thr 
    690                 695                 700                 
Leu Gln Ser Phe Phe Ala Asn Gln Gly Thr Lys Val Arg Val Val Asn 
705                 710                 715                 720 
Gly Ser Phe Thr His Thr Leu Arg Lys Lys Trp Gly Ala Asp Leu Asp 
                725                 730                 735     
Lys Thr Arg Glu Thr His His His His Ala Val Asp Ala Thr Leu Cys 
            740                 745                 750         
Ala Val Thr Pro Phe Val Lys Val Ser Arg Tyr His Tyr Ala Val Lys 
        755                 760                 765             
Glu Glu Thr Gly Glu Lys Val Met Arg Glu Ile Asp Phe Glu Thr Gly 
    770                 775                 780                 
Glu Ile Val Asp Glu Met Ser Tyr Gln Glu Phe Lys Lys Ser Lys Lys 
785                 790                 795                 800 
Tyr Glu Arg Lys Thr Tyr Gln Val Lys Trp Pro Asn Phe Arg Glu Gln 
                805                 810                 815     
Leu Lys Pro Val Asn Leu His Pro Arg Ile Lys Phe Ser His Gln Val 
            820                 825                 830         
Asp Arg Lys Ala Asn Arg Lys Leu Ser Asp Ala Thr Ile Tyr Ser Val 
        835                 840                 845             
Arg Glu Lys Thr Glu Val Lys Thr Leu Lys Ser Gly Lys Gln Lys Ile 
    850                 855                 860                 
Thr Thr Asp Glu Tyr Thr Ile Gly Lys Ile Lys Asp Ile Tyr Thr Val 
865                 870                 875                 880 
Asp Gly Trp Glu Ala Phe Lys Lys Lys Gln Asp Lys Leu Leu Met Lys 
                885                 890                 895     
Asp Leu Asp Glu Lys Thr Tyr Glu Arg Leu Leu Ser Ile Ala Glu Thr 
            900                 905                 910         
Thr Pro Asp Phe Gln Glu Val Glu Glu Lys Asn Gly Lys Val Lys Arg 
        915                 920                 925             
Val Lys Arg Ser Pro Phe Ala Val Tyr Cys Glu Glu Asn Asp Ile Pro 
    930                 935                 940                 
Ala Ile Arg Lys Tyr Ala Lys Lys Asn Asn Gly Pro Leu Ile Arg Ser 
945                 950                 955                 960 
Leu Lys Tyr Tyr Asp Gly Lys Leu Asn Lys His Ile Asn Ile Thr Lys 
                965                 970                 975     
Asp Ser Gln Gly Arg Pro Val Glu Lys Thr Lys Asn Gly Arg Lys Val 
            980                 985                 990         
Thr Leu Gln Ser Leu Lys Pro Tyr  Arg Tyr Asp Ile Tyr  Gln Asp Leu 
        995                 1000                 1005             
Glu Thr  Lys Ala Tyr Tyr Thr  Val Gln Leu Tyr Tyr  Ser Asp Leu 
    1010                 1015                 1020             
Arg Phe  Val Glu Gly Lys Tyr  Gly Ile Thr Glu Lys  Glu Tyr Met 
    1025                 1030                 1035             
Lys Lys  Val Ala Glu Gln Thr  Lys Gly Gln Val Val  Arg Phe Cys 
    1040                 1045                 1050             
Phe Ser  Leu Gln Lys Asn Asp  Gly Leu Glu Ile Glu  Trp Lys Asp 
    1055                 1060                 1065             
Ser Gln  Arg Tyr Asp Val Arg  Phe Tyr Asn Phe Gln  Ser Ala Asn 
    1070                 1075                 1080             
Ser Ile  Asn Phe Lys Gly Leu  Glu Gln Glu Met Met  Pro Ala Glu 
    1085                 1090                 1095             
Asn Gln  Phe Lys Gln Lys Pro  Tyr Asn Asn Gly Ala  Ile Asn Leu 
    1100                 1105                 1110             
Asn Ile  Ala Lys Tyr Gly Lys  Glu Gly Lys Lys Leu  Arg Lys Phe 
    1115                 1120                 1125             
Asn Thr  Asp Ile Leu Gly Lys  Lys His Tyr Leu Tyr  Tyr Glu Lys 
    1130                 1135                 1140             
Glu Pro  Lys Asn Ile Ile Lys  
    1145                 1150 

<210>  57
<211>  1456
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Cas-Locus 16

<400>  57
Met Val Ser His Lys Met Ile Thr Phe Phe Leu Phe Ile Phe Met Leu 
1               5                   10                  15      
Tyr Glu Asn Gln Ile Ala Met Thr Lys Asn Ile Leu Gly Leu Asp Leu 
            20                  25                  30          
Gly Thr Asn Ser Ile Gly Trp Ala Leu Ile Lys Gln Asp Phe Glu Asn 
        35                  40                  45              
Lys Gln Gly Glu Ile Leu Gly Met Gly Ser Arg Ile Ile Pro Met Ser 
    50                  55                  60                  
Gln Asp Ile Leu Gly Glu Phe Gly Lys Gly Asn Ser Val Ser Gln Thr 
65                  70                  75                  80  
Ala Ser Arg Thr Ser Tyr Arg Gly Val Arg Arg Leu Arg Glu Arg Phe 
                85                  90                  95      
Leu Leu Arg Arg Glu Arg Leu His Arg Val Leu Asn Val Leu Asn Phe 
            100                 105                 110         
Leu Pro Ala His Tyr Ala Ser Gln Ile Asp Phe Glu Lys Arg Phe Gly 
        115                 120                 125             
Lys Phe Lys Glu Glu Thr Glu Pro Lys Leu Val Tyr Asp Val Asn Glu 
    130                 135                 140                 
Phe Ile Phe Lys Asn Ser Phe Glu Glu Met Leu Tyr Asp Phe Arg Lys 
145                 150                 155                 160 
Tyr Gln Pro Gln Leu Leu Glu Asn Asp Lys Lys Val Pro Tyr Asp Trp 
                165                 170                 175     
Thr Ile Tyr Tyr Leu Arg Asn Lys Ala Leu Thr Gln Lys Ile Glu Lys 
            180                 185                 190         
Glu Glu Leu Ala Trp Ile Leu Leu Asn Phe Asn Gln Lys Arg Gly Tyr 
        195                 200                 205             
Tyr Gln Leu Arg Gly Glu Asp Phe Glu Glu Glu Lys Asp Lys Thr Phe 
    210                 215                 220                 
Val Arg Leu Lys Val Asp Lys Ile Val Asp Ser Gly Asp Thr Ile Lys 
225                 230                 235                 240 
Gly Lys Ile Leu Tyr Asp Val Tyr Phe Glu Asn Gly Trp Lys Tyr Asp 
                245                 250                 255     
Lys Gln Ile Val Lys Thr Glu Asp Trp Ile Glu Arg Val Lys Glu Phe 
            260                 265                 270         
Ile Val Thr Glu Ser Phe Leu Lys Asn Gly Asp Ile Lys Arg Thr Phe 
        275                 280                 285             
Lys Ala Val Asp Ser Glu Lys Asp Trp Ile Ala Ile Lys Thr Lys Thr 
    290                 295                 300                 
Glu Gln Glu Ile Asp Asn Ser Asn Lys Thr Val Gly Thr Tyr Ile Tyr 
305                 310                 315                 320 
Glu Thr Leu Leu Arg Asn Pro Lys Gln Lys Ile Lys Gly Lys Leu Val 
                325                 330                 335     
Arg Thr Ile Glu Arg Lys Phe Tyr Lys Asp Glu Leu Lys Gln Ile Leu 
            340                 345                 350         
Glu Lys Gln Lys Glu Phe His Leu Glu Leu Lys Asn Asp Asp Leu Tyr 
        355                 360                 365             
Ser Asp Cys Ile Arg Glu Leu Tyr Arg Asn Asn Glu Ala His Gln Leu 
    370                 375                 380                 
Thr Leu Ser Arg Lys Asp Phe Val His Leu Leu Met Glu Asp Ile Ile 
385                 390                 395                 400 
Phe Tyr Gln Arg Pro Leu Arg Ser His Lys Ser Ser Ile Ser Asn Cys 
                405                 410                 415     
Thr Leu Glu Phe Arg Lys Tyr Lys Asp Glu Asn Gly Ala Glu His Ile 
            420                 425                 430         
Gln Tyr Leu Lys Ala Ile Pro Lys Ser Asn Pro Tyr Tyr Gln Glu Phe 
        435                 440                 445             
Arg Ile Trp Gln Trp Ile Phe Asn Leu Asn Ile Tyr Lys Arg Asp Asp 
    450                 455                 460                 
Glu Gln Asn Pro Val Thr Lys Lys Phe Leu Asn Thr Thr Gln Asp Phe 
465                 470                 475                 480 
Glu Asn Leu Phe Glu Phe Leu Asn Asn Arg Lys Glu Ile Asp Gln Lys 
                485                 490                 495     
Ala Leu Leu Lys His Leu Lys Ile Asn Glu Lys Thr His Arg Trp Lys 
            500                 505                 510         
Tyr Val Glu Asp Lys Lys Tyr Pro Cys Asn Glu Thr Lys Thr Met Ile 
        515                 520                 525             
Ser Ser Arg Leu Asp Lys Val Glu Asn Ile Ser Glu Asn Phe Leu Thr 
    530                 535                 540                 
Arg Glu Ile Glu Gln Lys Ile Trp His Ile Ile Tyr Ser Val Asn Asp 
545                 550                 555                 560 
Lys Ile Glu Tyr Glu Lys Ala Leu Lys Ser Phe Ala Asn Lys Asn Asn 
                565                 570                 575     
Leu Asp Glu Val Ser Phe Phe Glu Ala Phe Lys Lys Phe Pro Pro Phe 
            580                 585                 590         
Lys Ser Glu Tyr Gly Ser Phe Ser Glu Lys Ala Ile Lys Lys Leu Leu 
        595                 600                 605             
Pro Leu Met Arg Leu Gly Lys Tyr Trp Asn Tyr Ala Asp Ile Asp Lys 
    610                 615                 620                 
Tyr Ser Lys Asp Arg Ile Gln Lys Ile Ile Asn Gly Glu Tyr Asp Glu 
625                 630                 635                 640 
Asn Ile Lys Asp Lys Val Arg Glu Lys Ala Val His Leu Thr Thr Glu 
                645                 650                 655     
Asn Asp Phe Gln Gly Gln Gln Leu Trp Leu Ala Gln Tyr Ile Val Tyr 
            660                 665                 670         
Gly Arg His Ser Glu Ala Ser Met Ile Gly Lys Trp Asn Ser Ala Asp 
        675                 680                 685             
Asp Leu Glu Glu Phe Leu Lys Glu Phe Lys Gln His Ser Leu Arg Asn 
    690                 695                 700                 
Pro Ile Val Glu Gln Val Ile Thr Glu Thr Leu Arg Val Val Lys Asp 
705                 710                 715                 720 
Ile Trp Leu Lys Tyr Gly Asn Gly Ala Lys Asp Phe Phe Asn Glu Ile 
                725                 730                 735     
His Ile Glu Leu Gly Arg Glu Met Lys Leu Pro Ala Asp Asp Arg Lys 
            740                 745                 750         
Lys Leu Thr Asn Gln Ile Ser Glu Asn Glu Asn Thr Asn Leu Arg Ile 
        755                 760                 765             
Lys Ala Leu Leu Ala Glu Met Ile Asn Asp His Ser Val Glu Asn Val 
    770                 775                 780                 
Arg Pro Phe Ser Pro Met Gln Gln Glu Ile Leu Lys Ile Tyr Glu Asp 
785                 790                 795                 800 
Gly Val Leu Asn Ser Gly Ile Glu Ile Glu Asp Glu Tyr Leu Lys Ile 
                805                 810                 815     
Ser Lys Thr Ala Gln Pro Ser Pro Ser Asp Leu Lys Arg Tyr Lys Leu 
            820                 825                 830         
Trp Leu Glu Gln Lys Tyr Lys Ser Pro Tyr Thr Gly Gln Ile Ile Pro 
        835                 840                 845             
Leu Asn Lys Leu Phe Thr Pro Glu Tyr Glu Ile Glu His Ile Ile Pro 
    850                 855                 860                 
Gln Ser Arg Tyr Phe Asp Asp Ser Phe Ser Asn Lys Ile Ile Cys Glu 
865                 870                 875                 880 
Ser Ala Val Asn Lys Leu Lys Asp Asn Tyr Ile Gly Leu Gly Phe Ile 
                885                 890                 895     
Lys Gln Phe Gly Gly Thr Ile Ile Glu Leu Gly Phe Gly Lys Asn Val 
            900                 905                 910         
Lys Val Phe Glu Val Glu Glu Tyr Glu Asp Phe Val Lys Lys His Tyr 
        915                 920                 925             
Ala Asn Asn Arg Ser Lys Arg Asn Lys Leu Leu Leu Glu Glu Ile Pro 
    930                 935                 940                 
Glu Lys Met Ile Glu Arg Gln Leu Asn Asp Thr Arg His Ile Ser Lys 
945                 950                 955                 960 
Tyr Ile Ser Gly Val Leu Ser Asn Ile Val Arg Val Glu Asp Gly Thr 
                965                 970                 975     
Asp Glu Gly Val Asn Ser Lys Asn Ile Val Pro Gly Asn Gly Lys Ile 
            980                 985                 990         
Thr Thr Gln Leu Lys Gln Asp Trp  Gly Leu Asn Asp Val  Trp Asn Asp 
        995                 1000                 1005             
Leu Ile  Leu Pro Arg Phe Glu  Arg Met Asn Gln Leu  Thr Asn Ser 
    1010                 1015                 1020             
Thr Asp  Phe Thr Ala Trp Asn  Glu Asn His Gln Lys  Tyr Leu Pro 
    1025                 1030                 1035             
Thr Val  Pro Ile Glu Phe Ser  Lys Gly Phe Ser Lys  Lys Arg Ile 
    1040                 1045                 1050             
Asp His  Arg His His Ala Leu  Asp Ala Leu Val Ile  Ala Cys Ala 
    1055                 1060                 1065             
Thr Lys  Asp His Val Asn Leu  Leu Asn Asn Gln Ser  Ala Lys Ser 
    1070                 1075                 1080             
Glu Thr  Lys Arg Tyr Asp Leu  Lys Lys Arg Leu Met  Lys Phe Glu 
    1085                 1090                 1095             
Lys Val  Val Tyr Asn His Thr  Gln Thr Gly Glu Lys  Ile Glu Arg 
    1100                 1105                 1110             
Asp Val  Pro Lys Lys Phe Leu  Lys Pro Trp Glu Asn  Phe Thr Val 
    1115                 1120                 1125             
Glu Ala  Lys Asn Ser Leu Glu  Lys Ile Ile Val Ser  Phe Lys Gln 
    1130                 1135                 1140             
Asn Leu  Arg Val Ile Asn Lys  Ala Thr Asn Tyr Tyr  Glu Lys Tyr 
    1145                 1150                 1155             
Val Glu  Lys Asp Gly Leu Lys  Thr Lys Glu Arg Val  Glu Gln Thr 
    1160                 1165                 1170             
Gly Thr  Asn Trp Ala Ile Arg  Lys Ser Leu His Glu  Glu Thr Val 
    1175                 1180                 1185             
Ser Gly  Lys Ile Asn Leu Pro  Trp Val Glu Thr Ser  Asn Gly Glu 
    1190                 1195                 1200             
Phe Ile  Thr Ala Thr Arg Lys  Ser Leu Asp Thr Ser  Phe Asn Leu 
    1205                 1210                 1215             
Glu Lys  Ile Lys Lys Ile Thr  Asp Ile Gly Ile Gln  Lys Ile Leu 
    1220                 1225                 1230             
Arg Asn  Tyr Leu Glu Ala Lys  Asp Gly Asn Pro Glu  Leu Ala Phe 
    1235                 1240                 1245             
Ser Pro  Glu Gly Ile Glu Asp  Leu Asn Lys Asn Val  Glu Lys Tyr 
    1250                 1255                 1260             
Asn Asp  Gly Lys Ser His Gln  Pro Ile Ile Lys Val  Arg Val Tyr 
    1265                 1270                 1275             
Glu Lys  Gly Lys Gly Arg Phe  Val Leu Gly Gln Thr  Gly Asn Lys 
    1280                 1285                 1290             
Ile Asp  Lys Tyr Val Gln Gly  Ser Pro Asn Leu Phe  Phe Ala Ile 
    1295                 1300                 1305             
Tyr Lys  Asp Asp Asn Gly Lys  Lys Ser Tyr Glu Ser  Ile Arg Leu 
    1310                 1315                 1320             
Asp Ile  Ala Ile Glu Arg Leu  Lys Gln Gly Leu Gln  Ala Val Pro 
    1325                 1330                 1335             
Glu Thr  Asn Gln Asn Gly Phe  Ala Leu Tyr Gln Ser  Leu Ser Pro 
    1340                 1345                 1350             
Leu Asp  Leu Val Tyr Ile Pro  Thr Glu Asp Glu Val  Glu Ser Pro 
    1355                 1360                 1365             
His Leu  Ile Asp Phe Ser Lys  Leu Asp Lys Ile Lys  Leu Glu Arg 
    1370                 1375                 1380             
Ile Tyr  Asn Val Asn Asp Phe  Ser Gly Tyr Thr Ile  Tyr Phe Ser 
    1385                 1390                 1395             
Gln Asn  Ser Phe Ala Lys Asn  Ile Tyr Pro Lys Glu  Met Asp Met 
    1400                 1405                 1410             
Thr Trp  Asn Glu Lys Lys Gln  Lys Pro Ser Gly Ser  Phe Asp Ser 
    1415                 1420                 1425             
Lys Thr  Ala Ser Tyr Asn Lys  Lys Ser Ile Lys Asp  Ile Phe Ile 
    1430                 1435                 1440             
Lys Met  Lys Ile Asp Arg Leu  Gly Asn Ile Ser Lys  Ala 
    1445                 1450                 1455     

<210>  58
<211>  1462
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Cas-Locus 17

<400>  58
Met Thr Asn Ile Glu Glu Lys Ile Phe Asn Thr Ile Met Gly Ile Arg 
1               5                   10                  15      
Asn Leu Asn Ala Phe Phe Ile Tyr Ile Leu Gly Asp Ile Gln Asn Ile 
            20                  25                  30          
Thr Val Met Ile Lys Asn Lys Leu Gly Leu Asp Leu Gly Thr Asn Ser 
        35                  40                  45              
Ile Gly Trp Ala Leu Ile Arg Gln Asp Phe Glu Asn Lys Tyr Gly Glu 
    50                  55                  60                  
Ile Leu Gly Met Gly Ser Arg Ile Ile Pro Met Ser Gln Asp Ile Leu 
65                  70                  75                  80  
Gly Asp Phe Gly Lys Gly Asn Ser Val Ser Gln Thr Ala Glu Arg Thr 
                85                  90                  95      
Lys Tyr Arg Ser Val Arg Arg Leu Arg Glu Arg Phe Leu Leu Arg Arg 
            100                 105                 110         
Glu Arg Leu His Arg Leu Leu His Leu Leu Asn Phe Leu Pro Gln His 
        115                 120                 125             
Tyr Ala Ser Gln Ile Asp Phe Glu Lys Arg Phe Gly Lys Phe Lys Val 
    130                 135                 140                 
Glu Thr Glu Pro Lys Leu Ala Trp Lys Asn Ile Glu Gly Lys Phe Ser 
145                 150                 155                 160 
Phe Leu Phe Gln Asn Ser Phe Asn Glu Met Leu Glu Asp Phe Asn Ala 
                165                 170                 175     
Asn Gly Gln Asp Leu Lys Ile Pro Tyr Asp Trp Thr Ile Tyr Phe Leu 
            180                 185                 190         
Arg Lys Lys Ala Leu Ser Gln Lys Ile Glu Lys Glu Glu Leu Ala Trp 
        195                 200                 205             
Ile Leu Leu Asn Phe Asn Gln Lys Arg Gly Tyr Tyr Gln Leu Arg Gly 
    210                 215                 220                 
Glu Glu Glu Glu Glu Asn Pro Asn Lys Gln Val Glu Phe Tyr Ser Leu 
225                 230                 235                 240 
Lys Val Ile Asp Val Leu Ala Asp Glu Pro Gln Lys Gly Lys Ser Asp 
                245                 250                 255     
Ile Trp Tyr Ser Leu Ile Leu Glu Asn Gly Trp Ile Tyr Arg Arg Ser 
            260                 265                 270         
Ser Lys Ile Pro Leu Phe Asp Trp Lys Asp Lys Thr Arg Asp Phe Ile 
        275                 280                 285             
Val Thr Thr Asp Leu Asn Asp Asp Gly Ser Ile Lys Lys Asp Lys Asp 
    290                 295                 300                 
Gly Asn Glu Lys Arg Ser Phe Arg Ala Pro Gly Glu Asn Asp Trp Thr 
305                 310                 315                 320 
Leu Val Lys Lys Lys Thr Glu Gln Glu Ile Glu Gln Ser His Lys Thr 
                325                 330                 335     
Val Gly Thr Tyr Ile Tyr Glu Ala Leu Leu Asp Asn Pro Lys Gln Lys 
            340                 345                 350         
Ile Lys Gly Lys Leu Ile Arg Thr Ile Glu Arg Lys Phe Tyr Lys Glu 
        355                 360                 365             
Glu Leu Arg Gln Ile Leu Glu Lys Gln Lys Glu Phe His Gln Glu Leu 
    370                 375                 380                 
Gln Ser Asp Asp Leu Tyr Asn Asp Cys Ile Arg Glu Leu Tyr Arg Asn 
385                 390                 395                 400 
Asn Glu Ser His Gln Leu Ile Leu Ser Lys Lys Asp Phe Val His Leu 
                405                 410                 415     
Leu Met Glu Asp Leu Ile Phe Tyr Gln Arg Pro Leu Arg Ser Gln Lys 
            420                 425                 430         
Ser Ser Val Ser Asn Cys Thr Leu Glu Phe Arg Lys Tyr Lys Asp Glu 
        435                 440                 445             
Asn Gly Ala Glu His Ile Gln Tyr Leu Lys Ala Ile Pro Lys Ser Asn 
    450                 455                 460                 
Pro Tyr Tyr Gln Glu Phe Arg Leu Trp Gln Trp Ile Tyr Asn Leu Asn 
465                 470                 475                 480 
Ile Tyr Arg Lys Asp Asp Glu Ala Asn Val Thr Lys Asp Phe Leu Asn 
                485                 490                 495     
Thr Thr Gln Asp Leu Glu Asn Leu Phe Glu Phe Leu Asn Ile Arg Lys 
            500                 505                 510         
Glu Ile Asp Gln Lys Gly Leu Leu Lys His Phe Lys Leu Asn Glu Lys 
        515                 520                 525             
Lys His Arg Trp Asn Phe Val Glu Glu Lys Lys Tyr Pro Cys Asn Glu 
    530                 535                 540                 
Thr Lys Thr Met Ile Ser Ser Arg Leu Asp Lys Val Asp Asn Ile Ser 
545                 550                 555                 560 
Asp Asp Phe Leu Thr Arg Asp Ile Glu Gln Lys Ile Trp His Ile Ile 
                565                 570                 575     
Tyr Ser Val Asn Asp Lys Val Glu Tyr Glu Lys Ala Leu Lys Ser Phe 
            580                 585                 590         
Ala Arg Lys Tyr His Leu Asp Glu Ser Ser Phe Phe Glu Ala Phe Arg 
        595                 600                 605             
Lys Phe Pro Pro Phe Lys Ser Glu Tyr Gly Ser Phe Ser Glu Lys Ala 
    610                 615                 620                 
Ile Lys Lys Leu Leu Ala Leu Met Arg Leu Gly Lys Tyr Trp Asn Tyr 
625                 630                 635                 640 
Ala Asp Val Asp Lys Phe Ser Lys Asp Arg Ile Gln Lys Ile Ile Asn 
                645                 650                 655     
Gly Glu Tyr Asp Glu Asn Ile Lys Asp Lys Val Arg Glu Lys Ala Ile 
            660                 665                 670         
Asn Leu Thr Ser Glu Asn Asp Phe Gln Gly Leu Gln Leu Trp Leu Ala 
        675                 680                 685             
Gln Tyr Ile Ile Tyr Gly Arg His Ser Glu Ala Ser Met Ile Gly Lys 
    690                 695                 700                 
Trp Asn Ser Ala Asp Asp Leu Glu Met Phe Leu Lys Asp Phe Lys Gln 
705                 710                 715                 720 
His Ser Leu Arg Asn Pro Ile Val Glu Gln Val Ile Thr Glu Thr Leu 
                725                 730                 735     
Arg Val Val Lys Asp Ile Trp Leu Lys Tyr Gly Asn Gly Ala Lys Asp 
            740                 745                 750         
Phe Phe Asn Glu Ile His Ile Glu Leu Gly Arg Glu Met Lys Leu Pro 
        755                 760                 765             
Ala Gly Asp Arg Lys Lys Leu Thr Asn Gln Ile Thr Glu Asn Glu Asn 
    770                 775                 780                 
Thr Asn Leu Arg Ile Lys Ala Leu Leu Ala Glu Met Met Asn Asp His 
785                 790                 795                 800 
Ser Val Glu Asn Val Arg Pro Phe Ser Pro Met Gln Gln Glu Ile Leu 
                805                 810                 815     
Lys Ile Tyr Glu Asp Gly Val Leu Asn Ser Gly Ile Glu Ile Glu Asp 
            820                 825                 830         
Glu Tyr Leu Lys Ile Ser Lys Thr Ala Gln Pro Ser Ser Ser Asp Leu 
        835                 840                 845             
Lys Arg Tyr Lys Leu Trp Leu Glu Gln Lys Tyr Lys Ser Pro Tyr Thr 
    850                 855                 860                 
Gly Gln Ile Ile Pro Leu Asn Lys Leu Phe Thr Pro Glu Tyr Glu Ile 
865                 870                 875                 880 
Glu His Ile Ile Pro Gln Ser Arg Tyr Phe Asp Asp Ser Phe Ser Asn 
                885                 890                 895     
Lys Val Ile Cys Glu Ser Ala Val Asn Lys Leu Lys Asp Asn Tyr Ile 
            900                 905                 910         
Gly Leu Gly Phe Ile Lys Gln Phe Gly Gly Thr Ile Ile Glu Leu Gly 
        915                 920                 925             
Phe Gly Lys Ser Val Lys Val Phe Asn Ile Glu Glu Tyr Glu Asp Phe 
    930                 935                 940                 
Val Lys Lys His Tyr Ala Asn Asn Arg Gly Lys Arg Asn Lys Leu Leu 
945                 950                 955                 960 
Met Glu Asp Ile Pro Gly Lys Met Ile Glu Arg Gln Leu Asn Asp Thr 
                965                 970                 975     
Arg Tyr Ile Ser Lys Tyr Val Ser Gly Ile Leu Ser Asn Ile Val Arg 
            980                 985                 990         
Val Glu Asp Gly Ser Asp Glu Gly  Val Asn Ser Lys Asn  Ile Val Pro 
        995                 1000                 1005             
Gly Asn  Gly Lys Ile Thr Thr  Gln Leu Lys Gln Asp  Trp Gly Leu 
    1010                 1015                 1020             
Asn Asp  Val Trp Asn Asp Ile  Ile Leu Pro Arg Phe  Glu Arg Met 
    1025                 1030                 1035             
Asn Gln  Leu Thr Asn Ser Lys  Asp Phe Thr Ala Trp  Asn Glu Asn 
    1040                 1045                 1050             
His Gln  Lys Phe Leu Pro Thr  Val Pro Ile Glu Phe  Ser Lys Gly 
    1055                 1060                 1065             
Phe Ser  Lys Lys Arg Ile Asp  His Arg His His Ala  Leu Asp Ala 
    1070                 1075                 1080             
Leu Val  Ile Ala Cys Ala Thr  Lys Asp His Val Asn  Leu Leu Asn 
    1085                 1090                 1095             
Asn Gln  Ser Ala Lys Ser Asp  Thr Lys Arg Tyr Asp  Leu Lys Lys 
    1100                 1105                 1110             
Lys Leu  Met Lys Phe Glu Lys  Val Val Tyr Tyr His  Thr Gln Thr 
    1115                 1120                 1125             
Gly Glu  Lys Ile Glu Arg Glu  Ile Pro Lys Gln Phe  Leu Lys Pro 
    1130                 1135                 1140             
Trp Glu  Asn Phe Thr Val Asp  Ala Lys His Asn Leu  Glu Ser Ile 
    1145                 1150                 1155             
Ile Val  Ser Phe Lys Gln Asn  Leu Arg Val Ile Asn  Lys Ala Thr 
    1160                 1165                 1170             
Asn Tyr  Tyr Glu Lys Tyr Val  Glu Lys Asp Gly Thr  Lys Asn Lys 
    1175                 1180                 1185             
Glu Arg  Val Glu Gln Thr Gly  Thr Asn Trp Ala Ile  Arg Lys Pro 
    1190                 1195                 1200             
Met His  Lys Asp Thr Val Ser  Gly Lys Val Asp Leu  Pro Trp Val 
    1205                 1210                 1215             
Lys Val  Pro Lys Gly Lys Ile  Leu Thr Ala Thr Arg  Lys Ser Leu 
    1220                 1225                 1230             
Asp Ile  Ser Phe Asp Leu Lys  Ser Ile Ala Ser Ile  Thr Asp Thr 
    1235                 1240                 1245             
Gly Ile  Gln Lys Ile Leu Arg  Asn Tyr Leu Lys Phe  Lys Gly Ser 
    1250                 1255                 1260             
Pro Glu  Leu Ala Phe Ser Pro  Glu Gly Ile Glu Asp  Leu Asn Lys 
    1265                 1270                 1275             
Asn Ile  Glu Lys Tyr Asn Asp  Gly Lys Ser His Gln  Pro Ile Asn 
    1280                 1285                 1290             
Lys Val  Arg Val Phe Glu Leu  Gly Ser Lys Phe Gln  Val Gly Gln 
    1295                 1300                 1305             
Thr Gly  Asn Lys Lys Asp Lys  Tyr Val Glu Ala Ala  Lys Gly Thr 
    1310                 1315                 1320             
Asn Leu  Phe Phe Ala Val Tyr  Glu Asn Glu Asn Arg  Asn Arg Ser 
    1325                 1330                 1335             
Tyr Glu  Thr Ile Pro Leu Asn  Glu Val Ile Glu Arg  Gln Lys Gln 
    1340                 1345                 1350             
Gly Leu  Ser Val Val Asp Leu  Lys Gly Thr Ile Asp  Phe Phe Leu 
    1355                 1360                 1365             
Cys Pro  Asn Asp Leu Val Tyr  Ile Pro Ser Glu Asp  Glu Leu Glu 
    1370                 1375                 1380             
Asn Ser  Ser Asn Ile Asp Phe  Lys Asn Phe Lys Glu  Glu Gln Asn 
    1385                 1390                 1395             
Lys Lys  Ile Tyr Lys Val Val  Ser Phe Ser Gly Ser  Gln Leu Phe 
    1400                 1405                 1410             
Phe Ile  Arg Gln Glu Ile Ala  Ile Ser Ile Val Asn  Lys Ala Glu 
    1415                 1420                 1425             
Phe Ser  Thr Leu Asn Lys Met  Glu Arg Ser Ile Asp  Gly Leu Met 
    1430                 1435                 1440             
Ile Lys  Glu Asn Cys Ile Lys  Leu Lys Val Asp Arg  Leu Gly Asn 
    1445                 1450                 1455             
Ile Ser  Lys Ala 
    1460         

<210>  59
<211>  1440
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Cas-Locus 18

<400>  59
Met Lys Asn Ile Leu Gly Leu Asp Leu Gly Thr Asn Ser Ile Gly Trp 
1               5                   10                  15      
Ala Leu Val Lys Gln Asp Phe Glu Asn Lys Gln Gly Glu Ile Leu Gly 
            20                  25                  30          
Met Gly Thr Arg Ile Ile Pro Met Ser Gln Asp Ile Leu Gly Asp Phe 
        35                  40                  45              
Gly Lys Gly Asn Ser Val Ser Gln Thr Ala Glu Arg Thr Lys Tyr Arg 
    50                  55                  60                  
Ser Val Arg Arg Leu Arg Glu Arg Phe Leu Leu Arg Arg Glu Arg Leu 
65                  70                  75                  80  
His Arg Val Leu Asn Ile Leu Asn Ser Leu Pro Glu His Tyr Ala Ser 
                85                  90                  95      
Gln Ile Asp Phe Glu Lys Arg Phe Gly Lys Phe Lys Val Glu Thr Glu 
            100                 105                 110         
Pro Lys Leu Ala Trp Lys Asn Ile Glu Gly His Phe Ser Phe Leu Phe 
        115                 120                 125             
Gln Asn Ser Phe Asn Glu Met Leu Glu Asp Phe Lys Thr Asn Gly Gln 
    130                 135                 140                 
Asp Leu Lys Ile Pro Tyr Asp Trp Thr Ile Tyr Tyr Leu Arg Lys Lys 
145                 150                 155                 160 
Ala Leu Ser Gln Lys Ile Glu Lys Glu Glu Leu Ala Trp Ile Leu Leu 
                165                 170                 175     
Asn Phe Asn Gln Lys Arg Gly Tyr Tyr Gln Leu Arg Gly Glu Glu Glu 
            180                 185                 190         
Glu Glu Asn Pro Asn Lys Ile Val Glu Phe Tyr Ser Leu Lys Val Val 
        195                 200                 205             
Asp Val Leu Ala Asp Glu Pro Gln Lys Ser Lys Ser Asp Ile Trp Tyr 
    210                 215                 220                 
Ser Leu Val Leu Glu Asn Gly Trp Ile Tyr Arg Arg Ala Ser Lys Ile 
225                 230                 235                 240 
Ser Leu Phe Asp Trp Lys Asp Lys Thr Arg Asp Phe Ile Val Thr Thr 
                245                 250                 255     
Asp Leu Asn Asp Asp Gly Ser Val Lys Thr Asp Lys Asp Gly Asn Glu 
            260                 265                 270         
Lys Arg Ser Phe Arg Ala Pro Gly Glu Asn Asp Trp Thr Leu Val Lys 
        275                 280                 285             
Lys Lys Thr Glu Gln Glu Ile Glu Gln Ser His Lys Thr Val Gly Ile 
    290                 295                 300                 
Tyr Ile Tyr Glu Thr Leu Leu Asn Asn Pro Lys Gln Lys Ile Lys Gly 
305                 310                 315                 320 
Lys Leu Val Arg Thr Ile Glu Arg Lys Phe Tyr Lys Glu Glu Leu Arg 
                325                 330                 335     
Gln Ile Leu Glu Lys Gln Lys Gln Phe His Gln Glu Leu Gln Asn Asp 
            340                 345                 350         
Asp Leu Tyr Asn Cys Cys Ile Arg Glu Leu Tyr Arg Asn Asn Glu Ala 
        355                 360                 365             
His Gln Leu Thr Leu Ser Lys Lys Asp Phe Val His Leu Phe Met Glu 
    370                 375                 380                 
Asp Ile Val Phe Tyr Gln Arg Pro Leu Arg Ser Gln Lys Ser Ser Ile 
385                 390                 395                 400 
Ser Asn Cys Thr Leu Glu Phe Arg Lys Tyr Lys Asp Glu Asn Gly Ala 
                405                 410                 415     
Glu His Thr Gln Tyr Leu Lys Ala Ile Pro Lys Ser Asn Pro Tyr Tyr 
            420                 425                 430         
Gln Glu Phe Arg Leu Trp Gln Trp Ile Phe Asn Leu Asn Leu Tyr Lys 
        435                 440                 445             
Lys Asp Asn Asp Glu Asn Val Ile Lys Glu Phe Leu Thr Thr Thr Gln 
    450                 455                 460                 
Asp Ile Glu Asn Leu Phe Glu Phe Leu Asn Asn Arg Lys Glu Ile Asp 
465                 470                 475                 480 
Gln Lys Ala Leu Leu Lys His Phe Lys Leu Asn Glu Lys Thr His Arg 
                485                 490                 495     
Trp Asn Phe Val Glu Asp Lys Lys Tyr Pro Cys Asn Glu Thr Lys Thr 
            500                 505                 510         
Met Ile Ser Thr Arg Leu Glu Lys Val Glu Asn Ile Ser Asp Asp Phe 
        515                 520                 525             
Leu Thr Arg Glu Ile Glu Gln Gln Ile Trp His Ile Ile Tyr Ser Val 
    530                 535                 540                 
Asn Asp Lys Ile Glu Tyr Glu Lys Ala Leu Lys Thr Phe Ala Ser Lys 
545                 550                 555                 560 
His His Leu Asp Glu Ser Ser Phe Phe Glu Ala Phe Arg Lys Phe Pro 
                565                 570                 575     
Pro Phe Lys Ser Glu Tyr Gly Ser Tyr Ser Glu Lys Ala Ile Lys Lys 
            580                 585                 590         
Leu Leu Pro Ile Met Arg Leu Gly Lys Tyr Trp Asp Tyr Ala Asn Ile 
        595                 600                 605             
Asp Gln Ser Ser Lys Asp Arg Ile Lys Lys Ile Ile Asn Gly Glu Tyr 
    610                 615                 620                 
Asp Glu Asn Ile Lys Asp Lys Val Arg Glu Lys Ala Val His Leu Thr 
625                 630                 635                 640 
Asn Glu Asn Asp Phe Gln Gly Leu Gln Leu Trp Leu Ala Gln Tyr Ile 
                645                 650                 655     
Val Tyr Gly Arg His Ser Glu Ala Ser Ile Thr Ala Lys Trp Asn Ser 
            660                 665                 670         
Ala Asp Asp Leu Glu Glu Phe Leu Lys Asp Phe Lys His His Ser Leu 
        675                 680                 685             
Arg Asn Pro Ile Val Glu Gln Val Ile Thr Glu Thr Leu Arg Val Val 
    690                 695                 700                 
Lys Asp Ile Trp Leu Lys Tyr Gly Lys Gly Ala Lys Asp Phe Phe Asn 
705                 710                 715                 720 
Glu Ile His Ile Glu Leu Gly Arg Glu Met Lys Leu Pro Ala Glu Asp 
                725                 730                 735     
Arg Lys Lys Leu Thr Ser Gln Ile Ile Glu Asn Glu Asn Thr Asn Leu 
            740                 745                 750         
Arg Ile Lys Ala Leu Leu Ala Glu Met Met Asn Asp His Ala Val Glu 
        755                 760                 765             
Asn Val Arg Pro Phe Ser Pro Gln Gln Gln Glu Ile Leu Lys Ile Tyr 
    770                 775                 780                 
Glu Asp Gly Val Leu Asn Ser Gly Ile Glu Ile Glu Asp Glu Tyr Leu 
785                 790                 795                 800 
Lys Ile Ser Lys Thr Ala Gln Pro Ser Pro Ser Asp Leu Lys Arg Tyr 
                805                 810                 815     
Lys Leu Trp Leu Glu Gln Lys Tyr Lys Ser Pro Tyr Thr Gly Gln Met 
            820                 825                 830         
Ile Pro Leu Asn Lys Leu Phe Thr Pro Glu Tyr Glu Ile Glu His Ile 
        835                 840                 845             
Ile Pro Gln Ser Arg Tyr Phe Asp Asp Ser Phe Ser Asn Lys Ile Ile 
    850                 855                 860                 
Cys Glu Ser Ala Val Asn Lys Leu Lys Asp Asn Tyr Ile Gly Leu Gly 
865                 870                 875                 880 
Phe Ile Lys Gln Phe Gly Gly Thr Ile Ile Glu Leu Gly Leu Gly Lys 
                885                 890                 895     
Ser Val Lys Val Phe Asp Ile Asp Gln Tyr Glu Asp Phe Val Lys Lys 
            900                 905                 910         
His Tyr Ala Asn Asn Arg Ser Lys Arg Asn Lys Leu Leu Leu Glu Asp 
        915                 920                 925             
Ile Pro Glu Lys Met Ile Glu Arg Gln Ile Asn Asp Thr Arg Tyr Ile 
    930                 935                 940                 
Ser Lys Tyr Ile Ser Gly Ile Leu Ser Asn Ile Val Arg Leu Glu Asp 
945                 950                 955                 960 
Gly Ser Asp Glu Gly Val Asn Ser Lys Asn Ile Val Pro Gly Asn Gly 
                965                 970                 975     
Lys Ile Thr Thr Gln Leu Lys Lys Asp Trp Gly Leu Asn Asp Val Trp 
            980                 985                 990         
Asn Asp Leu Ile Leu Pro Arg Phe  Lys Arg Met Asn Gln  Leu Thr Asn 
        995                 1000                 1005             
Ser Thr  Asp Phe Thr Ala Trp  Asn Glu Asn Phe Gln  Lys Phe Leu 
    1010                 1015                 1020             
Pro Thr  Val Pro Ile Glu Tyr  Ser Lys Gly Phe Ser  Lys Lys Arg 
    1025                 1030                 1035             
Ile Asp  His Arg His His Ala  Leu Asp Ala Leu Val  Ile Ala Cys 
    1040                 1045                 1050             
Ala Thr  Lys Asp His Val Asn  Leu Leu Asn Asn Gln  Ser Ala Lys 
    1055                 1060                 1065             
Ser Glu  Thr Lys Arg Tyr Asp  Leu Lys Lys Lys Leu  Met Lys Phe 
    1070                 1075                 1080             
Glu Arg  Val Val Tyr Phe His  Thr Gln Thr Gly Glu  Lys Ile Glu 
    1085                 1090                 1095             
Arg Glu  Val Pro Lys Gln Phe  Leu Lys Pro Trp Lys  Asn Phe Thr 
    1100                 1105                 1110             
Val Asp  Ala Met His Asn Leu  Glu Thr Val Ile Val  Ser Phe Lys 
    1115                 1120                 1125             
Gln Asn  Leu Arg Val Ile Asn  Lys Ala Thr Asn Tyr  Tyr Glu Lys 
    1130                 1135                 1140             
Tyr Val  Glu Lys Asp Gly Val  Arg Asn Lys Thr Arg  Ile Lys Gln 
    1145                 1150                 1155             
Lys Gly  Ile Asn Trp Ala Ile  Arg Lys Pro Met His  Lys Asp Thr 
    1160                 1165                 1170             
Val Ser  Gly Lys Val Asp Leu  Pro Trp Val Lys Val  Pro Lys Gly 
    1175                 1180                 1185             
Lys Ile  Leu Thr Ala Thr Arg  Lys Ser Leu Asp Ala  Ser Phe Asp 
    1190                 1195                 1200             
Leu Lys  Ser Ile Gly Ser Ile  Thr Asp Thr Gly Ile  Gln Lys Ile 
    1205                 1210                 1215             
Leu Lys  Asn Tyr Leu Met His  Lys Asp Gly Asn Thr  Glu Leu Ala 
    1220                 1225                 1230             
Phe Ser  Pro Glu Gly Ile Glu  Asp Leu Asn Lys Ser  Ile Glu Lys 
    1235                 1240                 1245             
Tyr Asn  Asp Gly Lys Pro His  Gln Pro Ile Asn Lys  Val Arg Val 
    1250                 1255                 1260             
Phe Glu  Leu Gly Ser Lys Phe  Gln Val Gly Gln Ala  Gly Asn Lys 
    1265                 1270                 1275             
Lys Asp  Lys Tyr Val Glu Ala  Ala Lys Gly Thr Asn  Leu Phe Phe 
    1280                 1285                 1290             
Gly Val  Tyr Glu Asp Lys Asn  Gly Lys Arg Ser Tyr  Glu Thr Ile 
    1295                 1300                 1305             
Pro Leu  Asn Glu Val Ile Glu  Arg Gln Lys Gln Gly  Leu Pro Val 
    1310                 1315                 1320             
Val Asp  Leu Arg Ser Thr Asn  Asp Phe Tyr Leu Cys  Pro Asn Asp 
    1325                 1330                 1335             
Leu Val  Tyr Ile Leu Ser Asp  Asp Glu Arg Gly Asn  Met Thr Asn 
    1340                 1345                 1350             
Ile Asp  Phe Glu Ser Leu Ser  Asp Glu Gln Val Lys  Arg Ile Tyr 
    1355                 1360                 1365             
Lys Phe  Val Ser Cys Thr Gly  Gly Glu Gly His Phe  Ile Pro Tyr 
    1370                 1375                 1380             
Ala Asn  Ala Thr Glu Ile Ile  Lys Asn Glu Asn Gly  Thr Asn Ser 
    1385                 1390                 1395             
Lys Ser  Glu Arg Met Gln Asn  Phe Tyr Asp Gly Ser  Cys Met Phe 
    1400                 1405                 1410             
Asp Lys  Asn Ala Lys Pro Ile  Met Ile Lys Glu Asn  Cys Val Lys 
    1415                 1420                 1425             
Leu Lys  Val Asp Arg Leu Gly  Asn Ile Ala Lys Ile  
    1430                 1435                 1440 

<210>  60
<211>  1440
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Cas-Locus 19

<400>  60
Met Lys Asn Ile Leu Gly Leu Asp Leu Gly Thr Asn Ser Ile Gly Trp 
1               5                   10                  15      
Ala Leu Val Lys Gln Asp Phe Glu Asn Lys Gln Gly Glu Ile Leu Gly 
            20                  25                  30          
Met Gly Val Arg Ile Ile Pro Met Ser Gln Asp Ile Leu Gly Asp Phe 
        35                  40                  45              
Gly Lys Gly Asn Ser Val Ser Gln Thr Ala Glu Arg Thr Lys Tyr Arg 
    50                  55                  60                  
Ser Val Arg Arg Leu Arg Glu Arg Phe Leu Leu Arg Arg Glu Arg Leu 
65                  70                  75                  80  
His Arg Val Leu Asn Ile Leu Asn Phe Leu Pro Glu His Tyr Ala Ser 
                85                  90                  95      
Gln Ile Asp Phe Glu Lys Arg Phe Gly Lys Phe Lys Val Glu Thr Glu 
            100                 105                 110         
Pro Lys Leu Ala Trp Lys Asn Ile Glu Gly Gln Phe Ser Phe Leu Phe 
        115                 120                 125             
Gln Asn Ser Phe Asn Glu Met Leu Glu Asp Phe Lys Ala Asn Gly Gln 
    130                 135                 140                 
Asp Leu Arg Ile Pro Tyr Asp Trp Thr Ile Tyr Tyr Leu Arg Lys Lys 
145                 150                 155                 160 
Ala Leu Tyr Gln Lys Ile Glu Lys Glu Glu Leu Ala Trp Ile Leu Leu 
                165                 170                 175     
Asn Phe Asn Gln Lys Arg Gly Tyr Tyr Gln Leu Arg Gly Glu Glu Glu 
            180                 185                 190         
Glu Glu Asn Pro Asn Lys Leu Val Glu Phe Tyr Ser Leu Lys Val Val 
        195                 200                 205             
Asp Val Leu Ala Asp Glu Pro Gln Lys Ser Lys Ser Asp Ile Trp Tyr 
    210                 215                 220                 
Ser Leu Val Leu Glu Asn Gly Trp Ile Tyr Arg Arg Ala Ser Lys Ile 
225                 230                 235                 240 
Leu Leu Phe Asp Trp Lys Asp Lys Thr Arg Asp Phe Ile Val Thr Thr 
                245                 250                 255     
Asp Leu Asn Asp Asp Gly Ser Val Lys Thr Asp Lys Glu Gly Asn Glu 
            260                 265                 270         
Lys Arg Ser Phe Arg Ala Pro Gly Glu Asn Asp Trp Thr Leu Val Lys 
        275                 280                 285             
Lys Lys Thr Glu Gln Lys Ile Glu Gln Ser His Lys Thr Val Gly Met 
    290                 295                 300                 
Tyr Ile Tyr Glu Thr Leu Leu Ala Asn Pro Lys Gln Lys Ile Lys Gly 
305                 310                 315                 320 
Lys Leu Val Arg Thr Ile Glu Arg Lys Phe Tyr Lys Glu Glu Leu Arg 
                325                 330                 335     
Gln Ile Leu Glu Lys Gln Lys Glu Phe His Gln Glu Leu Gln Asn Asp 
            340                 345                 350         
Asp Leu Tyr Asn Asp Cys Ile Arg Glu Leu Tyr Arg Asn Asn Glu Ala 
        355                 360                 365             
His Gln Leu Thr Leu Ser Lys Lys Asp Phe Ile His Leu Phe Ile Lys 
    370                 375                 380                 
Asp Ile Val Phe Tyr Gln Arg Pro Leu Arg Ser Gln Lys Ser Ser Ile 
385                 390                 395                 400 
Phe Asn Cys Thr Leu Glu Phe Arg Lys Tyr Lys Asp Glu Asn Gly Ala 
                405                 410                 415     
Glu His Thr Gln Tyr Leu Lys Ala Ile Pro Lys Ser Asn Pro Tyr Tyr 
            420                 425                 430         
Gln Glu Phe Arg Leu Trp Gln Trp Ile Phe Asn Leu Asn Leu Tyr Lys 
        435                 440                 445             
Lys Asp Asn Asp Glu Asn Val Ile Lys Glu Phe Leu Thr Thr Thr Gln 
    450                 455                 460                 
Asp Val Glu Asn Leu Phe Glu Phe Leu Asn Asn Arg Lys Glu Val Asp 
465                 470                 475                 480 
Gln Lys Thr Leu Leu Lys His Phe Lys Leu Asn Glu Lys Thr His Arg 
                485                 490                 495     
Trp Asn Phe Val Glu Asp Lys Lys Tyr Pro Cys Asn Glu Thr Lys Thr 
            500                 505                 510         
Met Ile Ser Thr Arg Leu Gln Lys Val Glu Asn Ile Ser Gly Asp Phe 
        515                 520                 525             
Leu Thr Arg Glu Ile Glu Gln Lys Ile Trp His Ile Ile Tyr Ser Val 
    530                 535                 540                 
Asn Asp Lys Ile Glu Tyr Glu Lys Ala Leu Lys Ser Phe Ala Leu Lys 
545                 550                 555                 560 
His Gln Leu Asp Lys Ser Ser Phe Phe Glu Ala Phe Arg Lys Phe Pro 
                565                 570                 575     
Pro Phe Lys Ser Glu Tyr Gly Ser Phe Ser Glu Lys Ala Ile Lys Lys 
            580                 585                 590         
Leu Leu Pro Leu Met Arg Leu Gly Lys Tyr Trp Asp Tyr Ala Asn Ile 
        595                 600                 605             
Asp Lys Phe Ser Lys Asp Arg Ile Gln Lys Ile Ile Asn Gly Glu Tyr 
    610                 615                 620                 
Asp Glu Asn Ile Lys Asp Arg Val Arg Glu Lys Ala Val His Leu Arg 
625                 630                 635                 640 
Ser Glu Asp Asp Phe Gln Gly Leu Gln Leu Trp Leu Ala Gln Tyr Ile 
                645                 650                 655     
Val Tyr Gly Arg His Ser Glu Ala Ser Ile Thr Gly Lys Trp Asn Ser 
            660                 665                 670         
Ala Asp Asp Leu Glu Glu Phe Leu Lys Asp Phe Lys His His Leu Leu 
        675                 680                 685             
Arg Asn Pro Ile Val Glu Gln Val Ile Thr Glu Thr Leu Arg Val Val 
    690                 695                 700                 
Lys Asp Ile Trp Leu Lys Tyr Gly Lys Gly Ala Lys Asp Phe Phe Asn 
705                 710                 715                 720 
Glu Ile His Ile Glu Leu Gly Arg Glu Met Lys Leu Pro Ala Asp Asp 
                725                 730                 735     
Arg Lys Lys Leu Thr Asn Gln Ile Thr Glu Asn Glu Asn Thr Asn Leu 
            740                 745                 750         
Arg Ile Lys Ala Leu Leu Thr Glu Met Met Asn Asp His Ala Val Glu 
        755                 760                 765             
Asn Val Arg Pro Phe Ser Pro Gln Gln Gln Glu Ile Leu Lys Ile Tyr 
    770                 775                 780                 
Glu Asp Gly Val Leu Asn Ser Gly Ile Glu Ile Glu Asp Glu Tyr Leu 
785                 790                 795                 800 
Lys Ile Ser Lys Thr Ala Gln Pro Phe Pro Ser Asp Leu Lys Arg Tyr 
                805                 810                 815     
Lys Leu Trp Leu Glu Gln Lys Tyr Lys Ser Pro Tyr Thr Gly Gln Ile 
            820                 825                 830         
Ile Pro Leu Asn Lys Leu Phe Thr Pro Glu Tyr Glu Ile Glu His Ile 
        835                 840                 845             
Ile Pro Gln Ser Arg Tyr Phe Asp Asp Ser Phe Ser Asn Lys Ile Ile 
    850                 855                 860                 
Cys Glu Ser Ala Val Asn Lys Leu Lys Asp Asn Tyr Ile Gly Leu Gly 
865                 870                 875                 880 
Phe Ile Lys Gln Phe Gly Gly Thr Ile Ile Glu Leu Gly Phe Gly Lys 
                885                 890                 895     
Ser Val Lys Val Phe Asp Ile Asp Glu Tyr Glu Asp Phe Val Lys Lys 
            900                 905                 910         
His Tyr Ala Asn Asn Arg Ser Lys Arg Asn Lys Leu Leu Leu Glu Asp 
        915                 920                 925             
Ile Pro Glu Lys Met Ile Glu Arg Gln Ile Asn Asp Thr Arg Tyr Ile 
    930                 935                 940                 
Ser Lys Tyr Ile Ser Gly Ile Leu Ser Asn Ile Val Arg Leu Glu Asp 
945                 950                 955                 960 
Gly Ser Asp Glu Gly Val Asn Ser Lys Asn Ile Val Pro Gly Asn Gly 
                965                 970                 975     
Lys Ile Thr Thr Gln Leu Lys Lys Asp Trp Gly Leu Asn Asp Val Trp 
            980                 985                 990         
Asn Asp Leu Ile Leu Pro Arg Phe  Lys Arg Met Asn Gln  Leu Thr Asn 
        995                 1000                 1005             
Ser Thr  Asp Phe Thr Ala Trp  Asn Glu Asn Phe Gln  Lys Phe Leu 
    1010                 1015                 1020             
Pro Thr  Val Pro Ile Glu Tyr  Ser Lys Gly Phe Ser  Lys Lys Arg 
    1025                 1030                 1035             
Ile Asp  His Arg His His Ala  Leu Asp Ala Leu Val  Ile Ala Cys 
    1040                 1045                 1050             
Ala Thr  Lys Asp His Val Asn  Leu Leu Asn Asn Gln  Ser Ala Lys 
    1055                 1060                 1065             
Ser Glu  Thr Lys Arg Tyr Asp  Leu Lys Lys Lys Leu  Met Lys Phe 
    1070                 1075                 1080             
Glu Arg  Val Val Tyr Leu His  Met Gln Thr Gly Glu  Lys Ile Glu 
    1085                 1090                 1095             
Arg Glu  Val Pro Lys Gln Phe  Leu Lys Pro Trp Glu  Asn Phe Thr 
    1100                 1105                 1110             
Val Asp  Val Lys Tyr Asn Leu  Asp Met Val Ile Val  Ser Phe Lys 
    1115                 1120                 1125             
Gln Asn  Leu Arg Val Ile Asn  Lys Ala Thr Asn Tyr  Tyr Glu Lys 
    1130                 1135                 1140             
Tyr Val  Glu Lys Asp Gly Ala  Arg Asn Lys Thr Arg  Val Glu Gln 
    1145                 1150                 1155             
Lys Gly  Ile Asn Trp Ala Ile  Arg Lys Pro Met His  Lys Asp Thr 
    1160                 1165                 1170             
Val Ser  Gly Lys Val Asp Leu  Pro Trp Val Lys Val  Pro Lys Gly 
    1175                 1180                 1185             
Lys Ile  Leu Thr Ala Thr Arg  Lys Ser Leu Asp Ala  Ser Phe Asp 
    1190                 1195                 1200             
Leu Lys  Ser Ile Ala Ser Ile  Thr Asp Thr Gly Ile  Gln Lys Ile 
    1205                 1210                 1215             
Leu Lys  Asn Tyr Leu Met Leu  Lys Asp Gly Asn Pro  Glu Leu Ala 
    1220                 1225                 1230             
Phe Ser  Pro Glu Gly Ile Glu  Asp Leu Asn Lys Ser  Ile Glu Lys 
    1235                 1240                 1245             
Tyr Asn  Asp Gly Lys Pro His  Gln Pro Ile Asn Lys  Val Arg Val 
    1250                 1255                 1260             
Phe Glu  Leu Gly Ser Lys Phe  Gln Ile Gly Gln Ala  Gly Asn Lys 
    1265                 1270                 1275             
Lys Asp  Lys Tyr Val Glu Ala  Ala Lys Gly Thr Asn  Leu Phe Phe 
    1280                 1285                 1290             
Ala Val  Tyr Glu Asp Glu Asn  Gly Lys Arg Ser Tyr  Glu Thr Ile 
    1295                 1300                 1305             
Pro Leu  Asn Glu Val Ile Glu  Arg Gln Lys His Gly  Leu Pro Val 
    1310                 1315                 1320             
Val Asp  Leu Thr Ser Thr Asn  Asp Phe Tyr Leu Cys  Pro Asn Asp 
    1325                 1330                 1335             
Leu Val  Tyr Ile Leu Ser Asp  Asp Glu Arg Asp Asn  Met Thr Asn 
    1340                 1345                 1350             
Asn Asp  Phe Glu Asn Leu Ser  Asp Glu Gln Val Lys  Arg Ile Tyr 
    1355                 1360                 1365             
Lys Phe  Val Ser Cys Thr Gly  Gly Glu Gly His Phe  Ile Pro Tyr 
    1370                 1375                 1380             
Ala Ser  Ala Thr Glu Ile Ile  Lys Asn Glu Asn Gly  Thr Asn Ser 
    1385                 1390                 1395             
Lys Ser  Glu Arg Ile Gln Asn  Phe Tyr Asp Gly Ser  Cys Met Leu 
    1400                 1405                 1410             
Asp Lys  Asn Ser Lys Pro Ile  Met Ile Lys Glu Asn  Cys Val Lys 
    1415                 1420                 1425             
Leu Lys  Val Asp Arg Leu Gly  Asn Ile Ser Lys Ile  
    1430                 1435                 1440 

<210>  61
<211>  1440
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Cas-Locus 20

<400>  61
Met Lys Asn Ile Leu Gly Leu Asp Leu Gly Thr Asn Ser Ile Gly Trp 
1               5                   10                  15      
Ala Leu Val Lys Gln Asp Phe Glu Asn Lys Gln Gly Glu Ile Leu Gly 
            20                  25                  30          
Met Gly Ala Arg Ile Ile Pro Met Ser Gln Asp Ile Leu Gly Asp Phe 
        35                  40                  45              
Gly Lys Gly Asn Ser Val Ser Gln Thr Ala Glu Arg Thr Lys Tyr Arg 
    50                  55                  60                  
Ser Val Arg Arg Leu Arg Glu Arg Phe Leu Leu Arg Arg Glu Arg Leu 
65                  70                  75                  80  
His Arg Val Leu Asn Ile Leu Asn Phe Leu Pro Glu His Tyr Ala Ser 
                85                  90                  95      
Gln Ile Asp Phe Glu Lys Arg Phe Gly Lys Phe Lys Val Glu Thr Glu 
            100                 105                 110         
Pro Lys Leu Ala Trp Lys Asn Ile Glu Gly Gln Phe Ser Phe Leu Phe 
        115                 120                 125             
Gln Asn Ser Phe Asn Glu Met Leu Glu Asp Phe Lys Ala Asn Gly Gln 
    130                 135                 140                 
Asp Leu Arg Ile Pro Tyr Asp Trp Thr Ile Tyr Tyr Leu Arg Lys Lys 
145                 150                 155                 160 
Ala Leu Tyr Gln Lys Ile Glu Lys Glu Glu Leu Ala Trp Ile Leu Leu 
                165                 170                 175     
Asn Phe Asn Gln Lys Arg Gly Tyr Tyr Gln Leu Arg Gly Glu Glu Glu 
            180                 185                 190         
Glu Glu Asn Pro Asn Lys Leu Val Glu Phe Tyr Ser Leu Lys Val Val 
        195                 200                 205             
Asp Val Leu Ala Asp Glu Pro Gln Lys Ser Lys Ser Asp Ile Trp Tyr 
    210                 215                 220                 
Ser Leu Val Leu Glu Asn Gly Trp Ile Tyr Arg Arg Ala Ser Lys Ile 
225                 230                 235                 240 
Leu Leu Phe Asp Trp Lys Asp Lys Thr Arg Asp Phe Ile Val Thr Thr 
                245                 250                 255     
Asp Leu Asn Asp Asp Gly Ser Val Lys Thr Asp Lys Glu Gly Asn Glu 
            260                 265                 270         
Lys Arg Ser Phe Arg Ala Pro Gly Glu Asn Asp Trp Thr Leu Val Lys 
        275                 280                 285             
Lys Lys Thr Glu Gln Glu Ile Glu Gln Ser His Lys Thr Val Gly Met 
    290                 295                 300                 
Tyr Ile Tyr Glu Thr Leu Leu Ala Asn Pro Lys Gln Lys Ile Lys Gly 
305                 310                 315                 320 
Lys Leu Val Arg Thr Ile Glu Arg Lys Phe Tyr Lys Glu Glu Leu Arg 
                325                 330                 335     
Gln Ile Leu Glu Lys Gln Lys Glu Phe His Gln Glu Leu Gln Asn Asp 
            340                 345                 350         
Asp Leu Tyr Asn Asp Cys Ile Arg Glu Leu Tyr Arg Asn Asn Glu Ala 
        355                 360                 365             
His Gln Leu Thr Leu Ser Lys Lys Asp Phe Ile His Leu Phe Ile Lys 
    370                 375                 380                 
Asp Ile Val Phe Tyr Gln Arg Pro Leu Arg Ser Gln Lys Ser Ser Ile 
385                 390                 395                 400 
Ser Asn Cys Thr Leu Glu Phe Arg Lys Tyr Lys Asp Glu Asn Arg Ala 
                405                 410                 415     
Glu His Thr Gln Tyr Leu Lys Ala Ile Pro Lys Ser Asn Pro Tyr Tyr 
            420                 425                 430         
Gln Glu Phe Arg Leu Trp Gln Trp Ile Phe Asn Leu Asn Leu Tyr Lys 
        435                 440                 445             
Lys Asp Asn Asp Glu Asn Val Ile Lys Glu Phe Leu Thr Thr Thr Gln 
    450                 455                 460                 
Asp Val Glu Asn Leu Phe Glu Phe Leu Asn Asn Arg Lys Glu Val Asp 
465                 470                 475                 480 
Gln Lys Thr Leu Leu Lys His Phe Lys Leu Asn Glu Lys Thr His Arg 
                485                 490                 495     
Trp Asn Phe Val Glu Asp Lys Lys Tyr Pro Cys Asn Glu Thr Lys Thr 
            500                 505                 510         
Met Ile Ser Thr Arg Leu Gln Lys Val Glu Asn Ile Ser Gly Asp Phe 
        515                 520                 525             
Leu Thr Arg Glu Ile Glu Gln Lys Ile Trp His Ile Ile Tyr Ser Val 
    530                 535                 540                 
Asn Asp Lys Ile Glu Tyr Glu Lys Ala Leu Lys Ser Phe Ala Leu Lys 
545                 550                 555                 560 
His Gln Leu Asp Lys Ser Ser Phe Phe Glu Ala Phe Arg Lys Phe Pro 
                565                 570                 575     
Pro Phe Lys Ser Glu Tyr Gly Ser Phe Ser Glu Lys Ala Ile Lys Lys 
            580                 585                 590         
Leu Leu Pro Leu Met Arg Leu Gly Lys Tyr Trp Asp Tyr Ala Asn Ile 
        595                 600                 605             
Asp Lys Phe Ser Lys Asp Arg Ile Gln Lys Ile Ile Asn Gly Glu Tyr 
    610                 615                 620                 
Asp Glu Asn Ile Lys Asp Arg Val Arg Glu Lys Ala Val His Leu Arg 
625                 630                 635                 640 
Ser Glu Asp Asp Phe Gln Gly Leu Gln Leu Trp Leu Ala Gln Tyr Ile 
                645                 650                 655     
Val Tyr Gly Arg His Ser Glu Ala Ser Ile Thr Gly Lys Trp Asn Ser 
            660                 665                 670         
Ala Asp Asp Leu Glu Glu Phe Leu Lys Asp Phe Lys His His Leu Leu 
        675                 680                 685             
Arg Asn Pro Ile Val Glu Gln Val Ile Thr Glu Thr Leu Arg Val Val 
    690                 695                 700                 
Lys Asp Ile Trp Leu Lys Tyr Gly Lys Gly Ala Lys Asp Phe Phe Asn 
705                 710                 715                 720 
Glu Ile His Ile Glu Leu Gly Arg Glu Met Lys Leu Pro Ala Asp Asp 
                725                 730                 735     
Arg Lys Lys Leu Thr Asn Gln Ile Thr Glu Asn Glu Asn Thr Asn Leu 
            740                 745                 750         
Arg Ile Lys Ala Leu Leu Thr Glu Met Met Asn Asp His Ala Val Glu 
        755                 760                 765             
Asn Val Arg Pro Phe Ser Pro Gln Gln Gln Glu Ile Leu Lys Ile Tyr 
    770                 775                 780                 
Glu Asp Gly Val Leu Asn Ser Gly Ile Glu Ile Glu Asp Glu Tyr Leu 
785                 790                 795                 800 
Lys Ile Ser Lys Thr Ala Gln Pro Ser Pro Ser Asp Leu Lys Arg Tyr 
                805                 810                 815     
Lys Leu Trp Leu Glu Gln Lys Tyr Lys Ser Pro Tyr Thr Gly Gln Ile 
            820                 825                 830         
Ile Pro Leu Asn Lys Leu Phe Thr Pro Glu Tyr Glu Ile Glu His Ile 
        835                 840                 845             
Ile Pro Gln Ser Arg Tyr Phe Asp Asp Ser Phe Ser Asn Lys Ile Ile 
    850                 855                 860                 
Cys Glu Ser Ala Val Asn Lys Leu Lys Asp Asn Tyr Ile Gly Leu Gly 
865                 870                 875                 880 
Phe Ile Lys Gln Phe Gly Gly Thr Ile Ile Glu Leu Gly Phe Gly Lys 
                885                 890                 895     
Ser Val Lys Val Phe Asp Ile Asp Glu Tyr Glu Asp Phe Val Lys Lys 
            900                 905                 910         
His Tyr Ala Asn Asn Arg Ser Lys Arg Asn Lys Leu Leu Leu Glu Asp 
        915                 920                 925             
Ile Pro Glu Lys Met Ile Glu Arg Gln Ile Asn Asp Thr Arg Tyr Ile 
    930                 935                 940                 
Ser Lys Tyr Ile Ser Gly Ile Leu Ser Asn Ile Val Arg Leu Glu Asp 
945                 950                 955                 960 
Gly Ser Asp Glu Gly Val Asn Ser Lys Asn Ile Val Pro Gly Asn Gly 
                965                 970                 975     
Lys Ile Thr Thr Gln Leu Lys Lys Asp Trp Gly Leu Asn Asp Val Trp 
            980                 985                 990         
Asn Asp Leu Ile Leu Pro Arg Phe  Lys Arg Met Asn Gln  Leu Thr Asn 
        995                 1000                 1005             
Ser Thr  Asp Phe Thr Ala Trp  Asn Glu Asn Phe Gln  Lys Phe Leu 
    1010                 1015                 1020             
Pro Thr  Val Pro Ile Glu Tyr  Ser Lys Gly Phe Ser  Lys Lys Arg 
    1025                 1030                 1035             
Ile Asp  His Arg His His Ala  Leu Asp Ala Leu Val  Ile Ala Cys 
    1040                 1045                 1050             
Ala Thr  Lys Asp His Val Asn  Leu Leu Asn Asn Gln  Ser Ala Lys 
    1055                 1060                 1065             
Ser Glu  Thr Lys Arg Tyr Asp  Leu Lys Lys Lys Leu  Met Lys Phe 
    1070                 1075                 1080             
Glu Arg  Val Val Tyr Leu His  Val Gln Thr Gly Glu  Lys Ile Glu 
    1085                 1090                 1095             
Arg Glu  Val Pro Lys Gln Phe  Leu Lys Pro Trp Glu  Asn Phe Thr 
    1100                 1105                 1110             
Val Asp  Val Lys His Asn Leu  Asp Thr Val Ile Val  Ser Phe Lys 
    1115                 1120                 1125             
Gln Asn  Leu Arg Val Ile Asn  Lys Ala Thr Asn Tyr  Tyr Glu Lys 
    1130                 1135                 1140             
Tyr Val  Glu Lys Asp Gly Ala  Arg Asn Lys Thr Arg  Val Glu Gln 
    1145                 1150                 1155             
Lys Gly  Ile Asn Trp Ala Ile  Arg Lys Pro Met His  Lys Asp Thr 
    1160                 1165                 1170             
Val Ser  Gly Lys Val Asp Leu  Pro Trp Val Lys Val  Pro Lys Gly 
    1175                 1180                 1185             
Lys Ile  Leu Thr Ala Thr Arg  Lys Ser Leu Asp Ala  Ser Phe Asp 
    1190                 1195                 1200             
Leu Lys  Ser Ile Ala Ser Ile  Thr Asp Thr Gly Ile  Gln Lys Ile 
    1205                 1210                 1215             
Ile Lys  Asn Tyr Leu Met Leu  Lys Asp Gly Asn Pro  Glu Leu Ala 
    1220                 1225                 1230             
Phe Ser  Pro Glu Gly Ile Glu  Asp Leu Asn Lys Ser  Ile Glu Lys 
    1235                 1240                 1245             
Tyr Asn  Asp Gly Lys Pro His  Gln Pro Ile Asn Lys  Val Arg Val 
    1250                 1255                 1260             
Phe Glu  Leu Gly Ser Lys Phe  Gln Ile Gly Gln Ala  Gly Asn Lys 
    1265                 1270                 1275             
Lys Asp  Lys Tyr Val Glu Ala  Ala Lys Gly Thr Asn  Leu Phe Phe 
    1280                 1285                 1290             
Ala Val  Tyr Glu Asp Glu Asn  Gly Lys Arg Ser Tyr  Glu Thr Ile 
    1295                 1300                 1305             
Pro Leu  Asn Glu Val Ile Glu  Arg Gln Lys His Gly  Leu Pro Val 
    1310                 1315                 1320             
Val Asp  Leu Thr Ser Thr Asn  Asp Phe Tyr Leu Cys  Pro Asn Asp 
    1325                 1330                 1335             
Leu Val  Tyr Ile Leu Ser Asp  Asp Glu Arg Asp Asn  Met Thr Asn 
    1340                 1345                 1350             
Asn Asp  Phe Glu Ser Leu Ser  Asp Glu Gln Val Lys  Arg Ile Tyr 
    1355                 1360                 1365             
Lys Phe  Val Ser Cys Thr Gly  Gly Glu Gly His Phe  Ile Pro Tyr 
    1370                 1375                 1380             
Ala Ser  Ala Thr Glu Ile Ile  Lys Asn Glu Asn Gly  Thr Asn Ser 
    1385                 1390                 1395             
Lys Ser  Glu Arg Met Gln Asn  Phe Tyr Asp Gly Ser  Cys Met Leu 
    1400                 1405                 1410             
Asp Lys  Asn Ser Lys Pro Ile  Met Ile Lys Glu Asn  Cys Val Lys 
    1415                 1420                 1425             
Leu Lys  Val Asp Arg Leu Gly  Asn Ile Ser Lys Ile  
    1430                 1435                 1440 

<210>  62
<211>  1233
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Cas-Locus 21

<400>  62
Met Gly Ser Arg Ile Ile Pro Leu Ser Thr Ser Asp Lys Glu Glu Phe 
1               5                   10                  15      
Gln Arg Gly Leu Ser Ile Thr Lys Asn Gln Ser Arg Thr Val Ser Arg 
            20                  25                  30          
Thr Gln Arg Lys Gly Tyr Asp Arg Lys Gln Leu Lys Lys Ser Asn Leu 
        35                  40                  45              
Lys Lys Ile Leu Asn Lys Tyr Asn Ile Phe Leu Ser Glu Glu Leu Leu 
    50                  55                  60                  
Lys Leu Pro Met Leu Asp Leu Trp Lys Leu Arg Ser Asp Ser Ala Asn 
65                  70                  75                  80  
Pro Asn Glu Asn Ile Ser Thr Glu Gln Leu Gly Arg Ile Leu Tyr Met 
                85                  90                  95      
Leu Asn Gln Lys Arg Gly Tyr Lys Ser Ala Arg Ser Glu Ala Asn Ala 
            100                 105                 110         
Asp Lys Lys Asp Thr Asp Tyr Val Gln Ala Val Lys Gly Arg Tyr Ala 
        115                 120                 125             
Gln Leu Lys Glu Arg Asn Gln Thr Ile Gly Gln Tyr Phe His Glu Glu 
    130                 135                 140                 
Leu His Asn Ala Asn Ala Asn Asn Ser Tyr Phe Arg Ile Lys Glu Glu 
145                 150                 155                 160 
Val Tyr Pro Arg Glu Ala Tyr Ile Glu Glu Phe Asp Thr Ile Ile Asn 
                165                 170                 175     
Ala Gln Lys Asp Lys His Asp Phe Leu Thr Asp Glu Val Val His Gln 
            180                 185                 190         
Leu Arg Asn Glu Ile Ile Tyr Phe Gln Arg Lys Leu Lys Ser Gln Lys 
        195                 200                 205             
Gly Leu Ile Asn Ile Cys Glu Phe Glu Gly Phe Glu Lys Thr Val Phe 
    210                 215                 220                 
Asp Lys Asp Lys Asn Lys His Lys Val Val Ser Val Gly Pro Lys Val 
225                 230                 235                 240 
Ala Pro Lys Thr Ser Pro Leu Phe Gln Leu Cys Arg Ile Trp Glu Val 
                245                 250                 255     
Val Asn Thr Ile Thr Leu Lys Ile Lys Asn Pro Glu Gly Ser Lys Tyr 
            260                 265                 270         
Lys Trp Gly Glu Lys Ile Pro Asn Leu Ile Glu Lys Glu Ile Leu Ala 
        275                 280                 285             
Asp Tyr Leu Leu Lys Asn Glu Ser Leu Ser Phe Thr Lys Leu Leu Glu 
    290                 295                 300                 
Ile Leu Glu Leu Asn Lys Asn Asp Ile Tyr Val Asn Lys Gln Ile Leu 
305                 310                 315                 320 
Lys Gly Ile Lys Gly Asn Glu Thr Tyr Ala Val Leu Gln Asn Ile Leu 
                325                 330                 335     
Gly Asp Asn Glu Leu Leu Asn Phe Asp Val Ser Ile Ile Pro Ser Asn 
            340                 345                 350         
Tyr Thr Ser Ile Leu Val Asp Lys Lys Thr Gly Glu Ile Leu Glu Glu 
        355                 360                 365             
Arg Ala Gly Leu Glu Leu Asp Ala Ser Leu Glu Lys Glu Pro Leu Tyr 
    370                 375                 380                 
Gln Leu Trp His Thr Ile Tyr Ser Leu Lys Asp Leu Asp Glu Cys Lys 
385                 390                 395                 400 
Asn Ala Leu Ile Lys Arg Phe Gly Phe Asp Asp Glu Ile Ala Glu Lys 
                405                 410                 415     
Leu Ser Arg Ile Asn Phe Asn Lys Gln Ala Phe Ser Asn Lys Ser Asn 
            420                 425                 430         
Lys Ser Met Arg Lys Ile Leu Pro Phe Leu Met Glu Gly Tyr Asp Tyr 
        435                 440                 445             
Ser Gln Ser Cys Ser Leu Ala Gly Tyr Asn His Ser Asn Ser Leu Thr 
    450                 455                 460                 
Lys Asp Glu Arg Glu Gln Gln Val Thr Leu Asn Arg Leu Glu Leu Leu 
465                 470                 475                 480 
Gln Lys Asn Ser Leu Arg Gln Pro Ile Val Glu Lys Ile Leu Asn Gln 
                485                 490                 495     
Met Ile Asn Val Val Asn Ala Ile Leu Glu Gln Tyr Gly Lys Pro Thr 
            500                 505                 510         
Glu Ile Arg Val Glu Leu Ala Arg Asp Leu Lys Gln Ser Lys Asp Glu 
        515                 520                 525             
Arg Asn Asp Ala Asp Leu Gln Asn Ser Lys Asn Lys Lys Leu Asn Glu 
    530                 535                 540                 
Glu Ile Gly Lys Arg Leu Ala Glu Leu Gly Leu Pro Ala Thr Lys Arg 
545                 550                 555                 560 
Tyr Ile Gln Lys Tyr Lys Phe Ile Phe Pro Ser Leu Ser Lys Asn Leu 
                565                 570                 575     
Lys Asp Ala Arg Val Asn Asn Gln Cys Ile Tyr Cys Gly Glu Thr Phe 
            580                 585                 590         
Asn Leu Thr Glu Ala Leu Ser Gly Asp Ala Phe Asp Val Asp His Ile 
        595                 600                 605             
Val Pro Lys Ala Leu Leu Phe Asp Asp Ser Gln Thr Asn Lys Val Leu 
    610                 615                 620                 
Val His Arg Lys Cys Asn Ser Thr Lys Thr Asn Gln Thr Ala Tyr Asp 
625                 630                 635                 640 
Tyr Ile Ala Thr Lys Gly Asp Glu Gln Val Arg Ile Tyr Ser Glu Arg 
                645                 650                 655     
Ile Asp Asp Trp Phe Lys Arg Gly Ile Ile Ser Tyr Ser Lys Met Gln 
            660                 665                 670         
Arg Leu Lys Val Ser His Lys Glu Tyr Leu Glu Arg Lys Lys Ile Gly 
        675                 680                 685             
Lys Glu Thr Glu Thr Asp Lys Lys Leu Trp Glu Asn Phe Ile Asp Arg 
    690                 695                 700                 
Gln Leu Arg Asp Thr Gln Tyr Ile Ser Arg Lys Ser Arg Glu Ile Leu 
705                 710                 715                 720 
Gln Lys Val Cys Asn Asn Val Thr Thr Thr Glu Gly Gly Val Thr Ala 
                725                 730                 735     
Lys Leu Arg Asn Leu Trp Gly Trp Asp Asp Val Leu Met Asn Leu Gln 
            740                 745                 750         
Met Pro Lys Tyr Lys Glu Leu Gly Gln Thr Val Ile Lys Glu Trp Thr 
        755                 760                 765             
Ser Asp His Gly Lys Arg Lys His Gln Lys Glu Glu Ile Glu Asn Trp 
    770                 775                 780                 
Thr Lys Arg Asp Asp His Arg His His Ala Ile Asp Ala Leu Val Ile 
785                 790                 795                 800 
Ala Cys Thr Arg Gln Gly Phe Ile Gln Arg Ile Asn Thr Leu Asn Ser 
                805                 810                 815     
Ser Asp Thr Lys Asp Leu Met Met Lys Glu Val Glu Lys Ala Lys Ile 
            820                 825                 830         
Glu Phe Asn Glu Lys Ser Thr Leu Leu Glu Lys Tyr Leu Lys Thr Gln 
        835                 840                 845             
Lys Pro Phe Thr Thr Glu Gln Val Met Lys Glu Ala Asp Lys Ile Leu 
    850                 855                 860                 
Val Ser Phe Lys Ala Gly Lys Lys Val Ala Thr Ile Thr Lys Phe Lys 
865                 870                 875                 880 
Ala Thr Gly Lys Asn Lys Asp Thr Gly Val Ile Val Pro Arg Gly Ala 
                885                 890                 895     
Leu His Glu Gln Asn Val Tyr Gly Lys Ile Lys Ala Ile Glu Lys Asp 
            900                 905                 910         
Lys Ser Leu Lys Tyr Leu Phe Glu Asn Ser Gly Lys Ile Val Asn Pro 
        915                 920                 925             
Lys Ile Lys Asn Leu Val Glu Ile Arg Leu Ser Glu Asn Glu Asn Ser 
    930                 935                 940                 
Ser Lys Met Ala Leu Ser Thr Leu Lys Lys Asn Pro Ile Phe Leu Asn 
945                 950                 955                 960 
Glu Glu Lys Thr Asp Leu Leu Glu Lys Ala Ser Cys Tyr Glu Tyr Val 
                965                 970                 975     
Thr Val Arg Lys Tyr Pro Leu Asn Thr Ile Lys Ala Ser Gln Ala Asp 
            980                 985                 990         
Asp Ile Val Asp Glu Arg Val Lys  Phe Leu Val Lys Glu  Arg Leu Ala 
        995                 1000                 1005             
Gln Phe  Gly Asn Lys Glu Lys  Glu Ala Phe Lys Asp  Thr Leu Trp 
    1010                 1015                 1020             
Phe Asn  Glu Glu Lys Gln Ile  Pro Ile Ile Thr Val  Arg Leu Phe 
    1025                 1030                 1035             
Ala Arg  Pro Asp Ala Asn Asn  Leu Gln Ala Met Lys  Lys Asp Glu 
    1040                 1045                 1050             
Asn Gly  Lys Glu Ile Gly Phe  Val Val Leu Gly Asn  Asn His His 
    1055                 1060                 1065             
Ile Ala  Ile Tyr Glu Asp Lys  Asp Asn Lys Leu Val  Gln His Ser 
    1070                 1075                 1080             
Cys Thr  Phe Trp His Ala Val  Glu Arg Lys Lys Tyr  Asn Ile Pro 
    1085                 1090                 1095             
Pro Val  Ile Lys Asn Ser Ser  Glu Ile Trp Asn Gln  Leu Leu Asn 
    1100                 1105                 1110             
Lys Glu  Phe Pro Glu Thr Phe  Leu Asp Lys Leu Pro  Ala Asp Asn 
    1115                 1120                 1125             
Leu Glu  Leu Lys Phe Ser Met  Gln Gln Asn Glu Met  Phe Ile Leu 
    1130                 1135                 1140             
Gly Leu  Pro Gln Glu Glu Phe  Glu Glu Ala Ile Lys  Asn Asn Asp 
    1145                 1150                 1155             
Lys Ser  Val Leu Ser Lys His  Met Tyr Leu Val Trp  Ser Ile Ala 
    1160                 1165                 1170             
Asp Gly  Asp Tyr Trp Phe Arg  His His Leu Glu Thr  Lys Asn Thr 
    1175                 1180                 1185             
Glu Leu  Lys Lys Ile Asn Gly  Ala Lys Glu Ser Lys  Arg Phe Phe 
    1190                 1195                 1200             
Arg Leu  Gln Ser Leu Lys Ala  Val Glu Asn Leu Thr  Pro Ile Lys 
    1205                 1210                 1215             
Val Arg  Leu Asn His Leu Gly  Glu Ile Thr Lys Ile  Gly Glu Tyr 
    1220                 1225                 1230             

<210>  63
<211>  1268
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Cas-Locus 22

<400>  63
Met Met Ile Lys Asn Ile Leu Gly Leu Asp Leu Gly Thr Asn Ser Ile 
1               5                   10                  15      
Gly Trp Ala Leu Ile Glu Val Asp Glu Asn Asn Ile Pro Ile Arg Ile 
            20                  25                  30          
Val Ala Met Gly Ser Arg Ile Ile Pro Leu Ser Thr Ser Asp Lys Glu 
        35                  40                  45              
Glu Phe Gln Arg Gly Leu Ser Ile Thr Lys Asn Gln Ser Arg Thr Val 
    50                  55                  60                  
Ser Arg Thr Gln Arg Lys Gly Tyr Asn Arg Lys Gln Leu Lys Lys Asn 
65                  70                  75                  80  
Asp Leu Lys Lys Ile Leu Asn Lys Tyr Asn Ile Phe Pro Ser Glu Glu 
                85                  90                  95      
Leu Leu Lys Leu Pro Met Leu Asp Leu Trp Lys Leu Arg Ser Asp Ser 
            100                 105                 110         
Ala Asn Pro Asn Glu Asn Ile Ser Ala Glu Gln Leu Gly Arg Ile Leu 
        115                 120                 125             
Tyr Met Leu Asn Gln Lys Arg Gly Tyr Lys Ser Ala Arg Ser Glu Ala 
    130                 135                 140                 
Asn Ala Asp Lys Lys Asp Thr Asp Tyr Val Gln Glu Val Lys Gly Arg 
145                 150                 155                 160 
Tyr Ala Gln Leu Lys Glu Arg Glu Gln Thr Ile Gly Gln Tyr Phe Tyr 
                165                 170                 175     
Glu Gly Leu Ser Thr Ala Phe Ser Asp Lys Asp Asn Arg Gln Tyr Phe 
            180                 185                 190         
Arg Ile Lys Glu Glu Val Tyr Pro Arg Glu Ala Tyr Val Glu Glu Phe 
        195                 200                 205             
Asp Thr Ile Ile Asn Ala Gln Lys Asp Lys His Asp Phe Leu Thr Asp 
    210                 215                 220                 
Lys Val Val His Gln Leu Arg Asn Glu Ile Ile Tyr Phe Gln Arg Lys 
225                 230                 235                 240 
Leu Lys Ser Gln Lys Gly Leu Val Ser Ile Cys Glu Phe Glu Gly Phe 
                245                 250                 255     
Glu Lys Thr Val Phe Asp Lys Glu Lys Asn Lys Asn Lys Val Val Phe 
            260                 265                 270         
Ile Gly Pro Lys Val Ala Pro Lys Thr Ser Pro Leu Phe Gln Leu Cys 
        275                 280                 285             
Arg Ile Trp Glu Val Val Asn Thr Ile Thr Leu Lys Ile Lys Asn Pro 
    290                 295                 300                 
Glu Gly Ser Lys Tyr Lys Trp Gly Glu Lys Ile Pro Asp Leu Lys Glu 
305                 310                 315                 320 
Lys Glu Ile Leu Ala Asp Tyr Leu Phe Lys Asn Glu Ser Val Ser Phe 
                325                 330                 335     
Ser Lys Leu Leu Glu Ile Leu Gly Leu Lys Lys Glu Asn Val Tyr Val 
            340                 345                 350         
Asn Lys Gln Ile Leu Lys Gly Ile Lys Gly Asn Glu Thr Tyr Ala Ala 
        355                 360                 365             
Leu Tyr Asn Val Leu Gly Asp Asn Glu Leu Leu Asn Phe Asn Val Ser 
    370                 375                 380                 
Ile Ile Thr Ser Asn His Thr Ala Ile Leu Ile Asp Lys Lys Thr Gly 
385                 390                 395                 400 
Glu Ile Leu Glu Glu Arg Ala Gly Leu Glu Leu Asp Ala Phe Leu Glu 
                405                 410                 415     
Lys Glu Pro Leu Tyr Gln Leu Trp His Thr Ile Tyr Ser Leu Lys Asp 
            420                 425                 430         
Leu Asp Glu Cys Lys Asn Ala Leu Ile Lys Arg Phe Gly Phe Glu Glu 
        435                 440                 445             
Asp Ile Ala Glu Lys Leu Ser Cys Ile Asp Phe Asn Lys Gln Ala Phe 
    450                 455                 460                 
Gly Asn Lys Ser Asn Lys Ser Met Arg Lys Ile Leu Pro Phe Leu Met 
465                 470                 475                 480 
Glu Gly Tyr Asp Tyr Ser Gln Ser Cys Ser Leu Ala Gly Tyr Asn His 
                485                 490                 495     
Ser Asn Ser Leu Thr Lys Asp Glu Arg Glu Gln Gln Ile Thr Leu Asp 
            500                 505                 510         
Arg Leu Glu Leu Leu Ser Lys Asn Ser Leu Arg Gln Pro Ile Val Glu 
        515                 520                 525             
Lys Ile Leu Asn Gln Met Ile Asn Val Val Asn Ala Ile Leu Glu Gln 
    530                 535                 540                 
Tyr Gly Lys Pro Ser Glu Ile Arg Val Glu Leu Ala Arg Gln Leu Lys 
545                 550                 555                 560 
Gln Ser Lys Asp Glu Arg Asn Glu Thr Asp Leu Gln Asn Ser Lys Asn 
                565                 570                 575     
Lys Lys Leu Asn Glu Glu Ile Gly Lys Arg Leu Ala Glu Leu Gly Leu 
            580                 585                 590         
Pro Val Thr Lys Arg Tyr Ile Gln Lys Tyr Lys Phe Ile Phe Pro Ser 
        595                 600                 605             
Leu Ser Lys Asn Leu Lys Asp Ala His Val Asn Asn Gln Cys Ile Tyr 
    610                 615                 620                 
Cys Gly Glu Thr Phe Asn Leu Thr Glu Ala Leu Ser Gly Asp Ala Tyr 
625                 630                 635                 640 
Asp Val Asp His Ile Val Pro Lys Thr Leu Leu Phe Asp Asp Ser Gln 
                645                 650                 655     
Thr Asn Lys Val Leu Val His Arg Lys Cys Asn Ser Thr Lys Thr Asn 
            660                 665                 670         
Gln Thr Ala Tyr Asp Tyr Ile Ala Thr Lys Gly Asp Glu Gln Val Arg 
        675                 680                 685             
Val Tyr Ser Glu Arg Val Asp Asp Trp Phe Lys Arg Gly Ile Ile Ser 
    690                 695                 700                 
Tyr Ser Lys Met Gln Arg Leu Lys Val Ser His Lys Glu Tyr Leu Glu 
705                 710                 715                 720 
Arg Lys Lys Leu Gly Lys Glu Thr Glu Thr Asp Lys Lys Leu Trp Glu 
                725                 730                 735     
Asn Phe Ile Asp Arg Gln Leu Arg Asp Thr Gln Tyr Ile Ser Arg Lys 
            740                 745                 750         
Ser Arg Glu Ile Leu Gln Lys Val Cys Asn Asn Val Thr Thr Thr Glu 
        755                 760                 765             
Gly Gly Val Thr Ala Lys Leu Arg Asn Val Trp Gly Trp Asp Asp Val 
    770                 775                 780                 
Leu Met Asn Leu Gln Leu Pro Lys Tyr Lys Glu Leu Gly Gln Thr Phe 
785                 790                 795                 800 
Thr Lys Glu Trp Thr Ser Lys His Gly Lys Arg Lys His Gln Lys Glu 
                805                 810                 815     
Glu Ile Glu Asn Trp Thr Lys Arg Asp Asp His Arg His His Ala Ile 
            820                 825                 830         
Asp Ala Leu Ile Ile Ala Cys Thr Lys Gln Gly Phe Ile Gln Arg Ile 
        835                 840                 845             
Asn Thr Leu Asn Ser Ser Glu Thr Lys Asp Leu Met Val Lys Glu Val 
    850                 855                 860                 
Glu Gly Ala Lys Ile Glu Phe Asn Glu Lys Ala Thr Leu Leu Glu Lys 
865                 870                 875                 880 
Tyr Leu Lys Thr Gln Lys Pro Phe Asp Thr His Glu Val Met Lys Glu 
                885                 890                 895     
Ala Asp Lys Ile Leu Ile Ser Phe Lys Ala Gly Lys Lys Val Ala Thr 
            900                 905                 910         
Ile Thr Lys Phe Lys Ala Thr Gly Lys Asn Lys Glu Thr Gly Val Ile 
        915                 920                 925             
Val Pro Arg Gly Ala Leu His Glu Gln Ser Val Tyr Gly Lys Ile Lys 
    930                 935                 940                 
Val Ile Glu Asn Asp Lys Pro Leu Lys Tyr Leu Phe Glu Asn Ser Asp 
945                 950                 955                 960 
Lys Ile Val Asn Pro Lys Ile Lys Asn Leu Val Glu Thr Arg Leu Thr 
                965                 970                 975     
Glu Asn Glu Asn Asn Phe Lys Lys Ala Leu Ser Thr Leu Lys Lys Asn 
            980                 985                 990         
Pro Ile Phe Phe Asn Glu Glu Lys  Thr Glu Ile Leu Glu  Lys Ala Ser 
        995                 1000                 1005             
Cys Tyr  Asn Asp Ala Thr Val  Leu Lys Tyr Lys Leu  Gln Asn Ile 
    1010                 1015                 1020             
Lys Ala  Ser Gln Ala Asp Asp  Ile Val Asp Glu Arg  Val Lys Ser 
    1025                 1030                 1035             
Leu Val  Lys Glu Arg Leu Ala  Gln Phe Gly Asn Lys  Glu Lys Glu 
    1040                 1045                 1050             
Ala Phe  Lys Asp Ile Leu Trp  Leu Asn Glu Glu Lys  Gln Ile Pro 
    1055                 1060                 1065             
Ile Ile  Thr Val Arg Leu Phe  Ala Arg Pro Asp Ala  Asp Asn Leu 
    1070                 1075                 1080             
Gln Ala  Ile Lys Lys Asp Lys  Tyr Gly Asn Glu Ile  Gly Phe Val 
    1085                 1090                 1095             
Val Thr  Gly Asn Asn His His  Ile Ala Ile Tyr Glu  Asp Lys Asp 
    1100                 1105                 1110             
Asn Lys  Leu Val Gln His Thr  Cys Thr Phe Trp His  Ala Ile Glu 
    1115                 1120                 1125             
Arg Lys  Lys Tyr Asn Ile Pro  Ala Val Ile Gly Asn  Ser Ser Asp 
    1130                 1135                 1140             
Ile Trp  Asn Gln Leu Leu Asp  Lys Glu Leu Pro Ile  Ser Phe Leu 
    1145                 1150                 1155             
Asn Lys  Leu Pro Met Asp Lys  Leu Asn Leu Lys Phe  Ser Val Gln 
    1160                 1165                 1170             
Gln Asn  Glu Met Phe Ile Leu  Gly Leu Ser Gln Asp  Glu Phe Asp 
    1175                 1180                 1185             
Glu Thr  Ile Lys Asn Asn Asp  Lys Ser Leu Leu Ser  Lys Tyr Leu 
    1190                 1195                 1200             
Tyr Leu  Val Trp Ser Ile Ala  Glu Gly Asp Tyr Trp  Phe Arg His 
    1205                 1210                 1215             
His Leu  Glu Thr Lys Asn Thr  Glu Leu Lys Lys Thr  Asp Gly Ala 
    1220                 1225                 1230             
Lys Glu  Ser Lys Arg Tyr Tyr  Arg Leu Ser Ser Lys  Gly Phe Ile 
    1235                 1240                 1245             
Asp Leu  Asn Pro Ile Lys Val  Arg Leu Asn His Leu  Gly Glu Ile 
    1250                 1255                 1260             
Thr Lys  Ile Gly Glu 
    1265             

<210>  64
<211>  1264
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Cas-Locus 23

<400>  64
Met Lys Lys Ile Leu Gly Leu Asp Leu Gly Thr Asn Ser Ile Gly Trp 
1               5                   10                  15      
Ala Leu Ile Glu Ile Asp Lys Asn Asn Ile Pro Ile Ser Ile Ile Ala 
            20                  25                  30          
Met Gly Ser Arg Ile Ile Pro Leu Ser Ser Ser Asp Lys Glu Glu Phe 
        35                  40                  45              
Gln Arg Gly Leu Ser Ile Thr Lys Asn Gln Ser Arg Thr Val Ser Arg 
    50                  55                  60                  
Thr Gln Arg Lys Gly Tyr Asp Arg Lys Gln Leu Lys Lys Ser Asp Leu 
65                  70                  75                  80  
Lys Lys Ile Leu Asn Lys Tyr Asn Ile Phe Pro Ser Glu Glu Leu Leu 
                85                  90                  95      
Lys Leu Pro Met Leu Asp Leu Trp Lys Leu Arg Ser Asp Ser Ala Asn 
            100                 105                 110         
Pro Asn Glu Asp Ile Ser Ala Glu Gln Leu Gly Arg Ile Leu Tyr Met 
        115                 120                 125             
Leu Asn Gln Lys Arg Gly Tyr Lys Ser Ala Arg Ser Glu Ala Asn Ala 
    130                 135                 140                 
Asp Lys Lys Asp Thr Asp Tyr Val Gln Ala Val Lys Gly Arg Tyr Ala 
145                 150                 155                 160 
His Leu Lys Asp Arg Thr Gln Thr Ile Gly Gln Tyr Phe Phe Glu Glu 
                165                 170                 175     
Leu Asp Asn Ala Asn Thr Asn Asn Ser Tyr Phe Arg Ile Lys Glu Glu 
            180                 185                 190         
Val Tyr Pro Arg Glu Ala Tyr Thr Glu Glu Phe Asp Ala Ile Ile Asn 
        195                 200                 205             
Ala Gln Lys Gly Lys His Asp Phe Leu Thr Asp Glu Val Val His Gln 
    210                 215                 220                 
Leu Arg Asn Glu Ile Ile Tyr Phe Gln Arg Lys Leu Lys Ser Gln Lys 
225                 230                 235                 240 
Gly Leu Val Ser Ile Cys Glu Phe Glu Gly Phe Glu Lys Thr Ile Phe 
                245                 250                 255     
Asp Lys Glu Lys Asp Lys Asn Lys Val Val Leu Val Gly Pro Lys Val 
            260                 265                 270         
Ala Pro Lys Thr Ser Pro Leu Phe Gln Leu Cys Arg Ile Trp Glu Val 
        275                 280                 285             
Val Asn Thr Ile Thr Leu Lys Ile Lys Asn Pro Glu Gly Ser Lys Tyr 
    290                 295                 300                 
Lys Trp Gly Glu Lys Ile Pro Asn Leu Lys Glu Lys Glu Ile Leu Ala 
305                 310                 315                 320 
Asp Tyr Leu Phe Lys Asn Glu Ser Leu Ser Phe Ser Lys Leu Leu Glu 
                325                 330                 335     
Ile Leu Glu Leu Lys Lys Glu Asn Val Tyr Val Asn Lys Gln Ile Leu 
            340                 345                 350         
Lys Gly Leu Lys Gly Asn Glu Thr Tyr Ser Thr Ile His Ser Ile Leu 
        355                 360                 365             
Gly Asp Asn Glu Leu Leu Asn Phe Asp Val Ser Ile Ile Thr Ser Asn 
    370                 375                 380                 
His Thr Ser Met Leu Val Asp Lys Lys Thr Gly Glu Ile Leu Glu Glu 
385                 390                 395                 400 
Arg Ala Gly Leu Glu Leu Asp Ala Ser Leu Glu Arg Glu Pro Leu Tyr 
                405                 410                 415     
Gln Leu Trp His Thr Ile Tyr Ser Leu Lys Asp Leu Asp Glu Cys Lys 
            420                 425                 430         
Asn Ala Leu Ile Lys Arg Phe Gly Phe Asp Asp Glu Ile Ala Lys Lys 
        435                 440                 445             
Leu Ser Arg Ile Asp Phe Asn Lys Gln Ala Phe Gly Asn Lys Ser Asn 
    450                 455                 460                 
Lys Ser Met Arg Lys Ile Leu Pro Phe Leu Met Glu Gly Tyr Asp Tyr 
465                 470                 475                 480 
Ser Gln Ser Cys Ser Leu Ala Gly Tyr Asn His Ser Asn Ser Leu Thr 
                485                 490                 495     
Lys Asp Glu Arg Glu Gln Leu Ile Thr Leu Asp Gln Leu Ala Leu Leu 
            500                 505                 510         
Pro Lys Asn Ser Leu Arg Gln Pro Ile Val Glu Lys Ile Leu Asn Gln 
        515                 520                 525             
Met Ile Asn Val Val Asn Ala Ile Leu Glu Gln Tyr Gly Lys Pro Ser 
    530                 535                 540                 
Glu Ile Arg Val Glu Leu Ala Arg Glu Leu Lys Gln Ser Lys Asp Glu 
545                 550                 555                 560 
Arg Asn Asp Thr Asp Leu Gln Asn Ser Lys Asn Lys Lys Leu Asn Glu 
                565                 570                 575     
Glu Ile Arg Lys Arg Leu Val Glu Leu Gly Leu Pro Val Thr Lys Arg 
            580                 585                 590         
Tyr Ile Gln Lys Tyr Lys Phe Ile Phe Pro Ser Leu Ser Lys Asn Leu 
        595                 600                 605             
Lys Asp Ala His Val Asn Asn Gln Cys Ile Tyr Cys Gly Glu Thr Phe 
    610                 615                 620                 
Asn Leu Thr Glu Ala Leu Ser Gly Asp Ala Tyr Asp Val Asp His Ile 
625                 630                 635                 640 
Val Pro Lys Ala Leu Leu Phe Asp Asp Ser Gln Thr Asn Lys Val Leu 
                645                 650                 655     
Val His Arg Lys Cys Asn Ser Thr Lys Asp Lys Leu Thr Ala Tyr Asp 
            660                 665                 670         
Tyr Ile Ser Thr Lys Gly Ile Glu Gln Val Arg Val Tyr Ser Glu Arg 
        675                 680                 685             
Val Asp Asp Trp Phe Lys Arg Gly Ile Ile Ser Tyr Ser Lys Met Gln 
    690                 695                 700                 
Arg Leu Lys Val Ser His Glu Glu Tyr Leu Glu Arg Lys Lys Ile Gly 
705                 710                 715                 720 
Lys Glu Thr Glu Thr Asp Lys Lys Leu Trp Glu Asn Phe Ile Glu Arg 
                725                 730                 735     
Gln Leu Arg Asp Thr Gln Tyr Ile Ser Arg Lys Ala Arg Glu Ile Leu 
            740                 745                 750         
His Lys Leu Cys Asn Asn Val Thr Thr Thr Glu Gly Gly Val Thr Ala 
        755                 760                 765             
Lys Leu Arg Asn Leu Trp Gly Trp Asp Asp Val Leu Met Asn Leu Gln 
    770                 775                 780                 
Met Pro Lys Tyr Lys Glu Leu Gly Gln Thr Val Ile Lys Glu Trp Ala 
785                 790                 795                 800 
Ser Asp His Gly Lys Arg Lys His Gln Lys Glu Glu Val Glu Asn Trp 
                805                 810                 815     
Thr Lys Arg Asp Asp His Arg His His Ala Ile Asp Ala Leu Val Ile 
            820                 825                 830         
Ala Cys Thr Lys Gln Gly Tyr Ile Gln Arg Ile Asn Thr Leu Asn Ser 
        835                 840                 845             
Ser Asp Thr Arg Asp Leu Met Ile Lys Glu Val Glu Glu Ala Lys Ile 
    850                 855                 860                 
Glu Phe Asn Glu Lys Ser Thr Leu Leu Glu Lys Tyr Leu Lys Thr Gln 
865                 870                 875                 880 
Glu Pro Phe Thr Thr Gln Glu Val Met Lys Glu Ala Asp Lys Ile Leu 
                885                 890                 895     
Ile Ser Phe Lys Ala Gly Lys Lys Val Ala Thr Ile Thr Lys Tyr Lys 
            900                 905                 910         
Ala Thr Gly Lys Asn Lys Asn Thr Gly Val Leu Val Pro Arg Gly Ala 
        915                 920                 925             
Leu His Glu Gln Asn Val Tyr Gly Lys Ile Lys Val Ile Glu Lys Asp 
    930                 935                 940                 
Lys Ser Leu Lys Tyr Leu Phe Glu Asn Ser Asp Lys Ile Val Asn Ser 
945                 950                 955                 960 
Ser Ile Lys Lys Leu Ile Glu Val Arg Leu Leu Asp Asn Glu Asn Asn 
                965                 970                 975     
Ser Lys Leu Ala Leu Ser Ser Leu Lys Lys Asn Pro Ile Phe Leu Asn 
            980                 985                 990         
Glu Glu Lys Lys Glu Val Leu Glu  Lys Ala Ser Cys Tyr  Glu Tyr Val 
        995                 1000                 1005             
Thr Val  Lys Lys Tyr Pro Leu  Asn Thr Ile Lys Ala  Asn Gln Ala 
    1010                 1015                 1020             
Asp Asp  Ile Val Asp Glu Arg  Val Lys Phe Leu Val  Lys Glu Arg 
    1025                 1030                 1035             
Leu Ser  Gln Phe Gly Asn Lys  Glu Lys Glu Ala Phe  Lys Asp Thr 
    1040                 1045                 1050             
Leu Trp  Phe Asn Glu Glu Lys  Gln Ile Pro Ile Ile  Thr Val Arg 
    1055                 1060                 1065             
Leu Phe  Ala Arg Pro Asp Ala  Asn Asn Leu Gln Ala  Ile Lys Lys 
    1070                 1075                 1080             
Asp Lys  Asn Gly Lys Glu Ile  Gly Phe Val Val Thr  Gly Asn Asn 
    1085                 1090                 1095             
His His  Ile Ala Ile Tyr Glu  Asp Lys Asp Asn Lys  Leu Ile Gln 
    1100                 1105                 1110             
His Ser  Cys Thr Phe Trp His  Ala Val Glu Arg Lys  Lys Tyr Asn 
    1115                 1120                 1125             
Val Pro  Thr Val Ile Lys Asn  Ser Ser Asp Val Trp  Asn Gln Leu 
    1130                 1135                 1140             
Leu His  Lys Glu Leu Pro Glu  Ser Phe Leu Asn Lys  Leu Pro Ala 
    1145                 1150                 1155             
Asp Tyr  Leu Asn Leu Lys Phe  Ser Met Gln Gln Asn  Glu Met Phe 
    1160                 1165                 1170             
Ile Leu  Gly Leu Ser Gln Glu  Glu Phe Asp Gln Ala  Ile Lys Lys 
    1175                 1180                 1185             
Asn Asn  Lys Pro Leu Leu Ser  Lys His Leu Tyr Leu  Val Trp Ser 
    1190                 1195                 1200             
Ile Thr  Asp Gly Asp Tyr Phe  Phe Arg His His Leu  Glu Thr Lys 
    1205                 1210                 1215             
Asn Thr  Glu Leu Lys Lys Thr  Asp Gly Ala Lys Glu  Gly Lys Arg 
    1220                 1225                 1230             
Tyr Phe  Arg Leu Ser Thr Lys  Gly Leu Thr Asp Leu  Asn Pro Ile 
    1235                 1240                 1245             
Lys Val  Arg Leu Asn His Leu  Gly Glu Ile Thr Lys  Ile Gly Glu 
    1250                 1255                 1260             
Tyr 
    

<210>  65
<211>  1464
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Cas-Locus 24

<400>  65
Met Ala Lys Ile Leu Gly Leu Asp Leu Gly Thr Asn Ser Ile Gly Trp 
1               5                   10                  15      
Ala Ile Val Asp Lys Asp Gly Asn Asp Phe Ser Leu Val Asp Lys Gly 
            20                  25                  30          
Val Arg Ile Phe Ser Glu Gly Val Lys Ser Glu Lys Gly Ile Glu Ser 
        35                  40                  45              
Ser Arg Ala Ala Glu Arg Thr Gly Tyr Arg Ser Ala Arg Lys Ile Lys 
    50                  55                  60                  
Tyr Arg Arg Lys Leu Arg Lys Tyr Glu Thr Leu Lys Val Leu Ser Ser 
65                  70                  75                  80  
Asn Gly Met Cys Pro Leu Ser Val Glu Glu Val Glu Asp Trp Lys Lys 
                85                  90                  95      
Ser Gly Phe Lys Lys Tyr Pro Leu Asn Pro Glu Phe Leu Lys Trp Leu 
            100                 105                 110         
Arg Thr Asp Glu Tyr Gln His Ile Asn Pro Tyr Tyr Phe Arg Asp Arg 
        115                 120                 125             
Ala Ser Lys Gln Lys Val Ala Leu Phe Glu Leu Gly Arg Ala Leu Tyr 
    130                 135                 140                 
His Ile Ala Gln Arg Arg Gly Phe Leu Ser Asn Arg Leu Asp Gln Ser 
145                 150                 155                 160 
Ala Glu Gly Val Phe Glu Glu His Asn Pro Gln Ile Gln Ser Leu Ile 
                165                 170                 175     
Glu Asp Leu Asp Asp Ser Lys Leu Ile Leu Asp Glu Leu Lys Asn Tyr 
            180                 185                 190         
Tyr Val Asp Lys Gly Ile Ile Glu Glu Ala Glu Lys Gly Val Phe Lys 
        195                 200                 205             
Lys Asp Leu Asp Glu Gly Glu Lys Lys Leu Lys Ser Leu Tyr Asn Ser 
    210                 215                 220                 
Leu Val Gly Ile Ile Lys Lys Asn Glu Asn Asn Val Glu Lys Cys Lys 
225                 230                 235                 240 
Glu Glu Phe Ile Ala Arg Leu Asn Lys Lys Glu Asp Leu Gly Lys Val 
                245                 250                 255     
Lys Gly Lys Ile Lys Asp Ile Ser Gln Ala Met Leu Asp Gly Asn Phe 
            260                 265                 270         
Lys Thr Leu Gly Gln Tyr Phe Phe Ser Leu Tyr Asn Lys Gly Lys Ile 
        275                 280                 285             
Arg Asn Gln Tyr Thr Ser Arg Glu Glu His Tyr Leu Glu Glu Phe Ile 
    290                 295                 300                 
Thr Ile Cys Lys Ile Gln Gly Ile Glu Gly Ile Asp Asp Lys Glu Lys 
305                 310                 315                 320 
Leu Pro Glu Lys Lys Phe Thr Gly Leu Ala Lys Asp Leu Tyr Lys Ala 
                325                 330                 335     
Ile Phe Phe Gln Arg Pro Leu Lys Ser Gln Lys Gly Leu Ile Gly Lys 
            340                 345                 350         
Cys Ser Phe Glu Lys Ser Lys Ser Arg Cys Ala Val Ser His Pro Asp 
        355                 360                 365             
Phe Glu Glu Tyr Arg Met Trp Thr Tyr Leu Asn Thr Ile Lys Ile Gly 
    370                 375                 380                 
Thr Gln Ser Glu Lys Thr Leu Arg Phe Leu Thr Gln Asp Glu Lys Leu 
385                 390                 395                 400 
Lys Leu Val Pro Lys Phe Tyr Arg Lys Asn Asp Phe Asn Phe Glu Val 
                405                 410                 415     
Leu Ala Lys Glu Leu Val Glu Lys Gly Ala Ser Phe Gly Phe Tyr Lys 
            420                 425                 430         
Ser Ser Lys Lys Asn Asp Phe Phe Tyr Trp Phe Asn Tyr Lys Pro Thr 
        435                 440                 445             
Asp Ser Val Ala Ala Cys Gln Val Ser Ala Ser Leu Lys Asn Val Ile 
    450                 455                 460                 
Gly Glu Asp Trp Lys Thr Lys Ile Phe Thr Tyr Lys Thr Leu Asn Ala 
465                 470                 475                 480 
Lys Glu Glu Glu Val Thr Lys Ser Val Asp Tyr Lys Asp Leu Trp His 
                485                 490                 495     
Leu Leu Ser Val Ala Thr Ser Asp Ile Tyr Leu Glu Glu Tyr Ala Lys 
            500                 505                 510         
Asp Lys Leu Gly Phe Asp Asp Lys Asn Ala Lys Ala Phe Ser Lys Ile 
        515                 520                 525             
Lys Leu Lys Lys Asp Phe Ala Ser Leu Ser Ser Ser Ala Ile Thr Lys 
    530                 535                 540                 
Ile Leu Pro Tyr Val Lys Glu Gly Leu Leu Tyr Ser His Ala Val Phe 
545                 550                 555                 560 
Met Ala Asn Ile Glu Asn Ile Val Asp Glu Asn Ile Trp Asn Asn Leu 
                565                 570                 575     
Asp Gln Arg Asn Tyr Ile Gln Ser Lys Ile Ala Glu Ile Ile Glu Gly 
            580                 585                 590         
Tyr Thr Phe Glu Lys Thr Gly Leu Glu Val Val Asn Ser Leu Ile Lys 
        595                 600                 605             
Glu Tyr Lys Thr Glu Asn Asp Tyr Ser Lys Lys Val Tyr Tyr Ser Lys 
    610                 615                 620                 
Glu Ala Glu Pro Glu Phe Glu Lys Asp Leu Lys Gln Lys Leu Val Val 
625                 630                 635                 640 
Phe Tyr Lys Ser Asn Asp Ile Glu Asp Glu Asn Ile Lys Gln Ala Ile 
                645                 650                 655     
Phe Asn Asp Leu Tyr Ser Val Leu Ile Asp Gln Leu Lys Lys Tyr Glu 
            660                 665                 670         
Tyr Ile Lys Ile Gln Arg Leu Asp Glu Lys Val Leu Glu Phe Leu Lys 
        675                 680                 685             
Gly Glu Asn Glu Asp Gly Glu Val Phe Cys Asn Asn Pro Lys Gln Leu 
    690                 695                 700                 
Lys Lys Leu Tyr His Pro Ser Asp Ile Glu Ile Phe Lys Lys Gln Lys 
705                 710                 715                 720 
Val Lys Asp Lys Asp Gly Lys Glu Thr Gly Gln Leu Ile Leu Gly Ser 
                725                 730                 735     
Pro Leu Thr Ser Ser Ile Lys Asn Pro Met Ala Met Arg Ala Leu His 
            740                 745                 750         
Gln Leu Arg Lys Val Leu Asn Thr Leu Ile Leu Glu Gly Gln Val Asp 
        755                 760                 765             
Glu Ser Thr Arg Ile His Ile Glu Met Ala Arg Glu Leu Asn Asp Ala 
    770                 775                 780                 
Asn Arg Arg Lys Gly Ile Gln Asp Tyr Gln Lys Glu Asn Lys Asp Phe 
785                 790                 795                 800 
Arg Asp Asn Ala Ile Lys Glu Ile Lys Lys Leu Tyr Leu Asp Glu Cys 
                805                 810                 815     
Gly Lys Glu Val Glu Pro Thr Glu Asp Asp Ile Leu Arg Tyr Gln Leu 
            820                 825                 830         
Trp Ile Glu Gln Asp Lys Cys Glu Ile Tyr Glu Gln Gly Lys Asn Ile 
        835                 840                 845             
Ser Ile Cys Asp Ile Ile Gly Ser Asn Pro Ala Tyr Asp Ile Glu His 
    850                 855                 860                 
Thr Ile Pro Arg Ser Ile Ser Gln Asp Asn Ser Gln Met Asn Lys Thr 
865                 870                 875                 880 
Leu Cys Ser Gln Arg Phe Asn Arg Asp Val Lys Lys Gln Lys Met Pro 
                885                 890                 895     
Ile Glu Leu Ser Asn His Leu Glu Ile Leu Pro Arg Ile Ala His Trp 
            900                 905                 910         
Lys Glu Glu Ala Asp Asn Leu Ser Arg Glu Ile Glu Ile Ile Ser Arg 
        915                 920                 925             
Ser Ile Lys Ala Ala Ser Thr Lys Glu Ile Lys Asp Lys Lys Ile Arg 
    930                 935                 940                 
Arg Arg His Tyr Leu Thr Leu Lys Arg Asp Tyr Leu Gln Gly Lys Tyr 
945                 950                 955                 960 
Asp Arg Phe Ile Trp Lys Glu Pro Lys Val Gly Phe Lys Asn Ser Gln 
                965                 970                 975     
Ile Pro Asp Thr Gly Ile Ile Thr Lys Tyr Ala Gln Ala Tyr Leu Lys 
            980                 985                 990         
Ser Tyr Phe Lys Arg Val Glu Ser  Val Lys Gly Gly Met  Val Ala Glu 
        995                 1000                 1005             
Phe Arg  Lys Gln Trp Gly Ile  Gln Glu Ser Phe Ile  Asp Glu Asn 
    1010                 1015                 1020             
Gly Phe  Lys Gln Tyr Lys Glu  Lys Asp Arg Ser Lys  His Thr His 
    1025                 1030                 1035             
His Thr  Ile Asp Ala Ile Thr  Ile Ala Cys Met Thr  Lys Asp Lys 
    1040                 1045                 1050             
Tyr Asp  Val Leu Ala Lys Ala  Trp Thr Ser Glu Asp  Glu Gln Asp 
    1055                 1060                 1065             
Lys Leu  Lys Ala Lys Ala Leu  Met Ala Asp Ala Lys  Pro Trp Lys 
    1070                 1075                 1080             
Thr Phe  Lys Glu Asp Leu Leu  Lys Ile Glu Asp Glu  Ile Leu Val 
    1085                 1090                 1095             
Ser His  Tyr Thr Pro Asp Asn  Val Lys Lys Gln Ser  Lys Lys Ile 
    1100                 1105                 1110             
Ile Arg  Val Arg Gly Lys Lys  Gln Phe Ile Ala Glu  Ile Glu Arg 
    1115                 1120                 1125             
Asp Val  Lys Gly Lys Ala Ile  Gln Lys Lys Asp Ala  Asn Gly Lys 
    1130                 1135                 1140             
Val Val  Tyr Lys Leu Asn Asp  Lys Gly Glu Lys Ile  Pro Arg Leu 
    1145                 1150                 1155             
Gln Gln  Gly Asp Thr Ile Arg  Gly Ser Leu His Gln  Asp Ser Ile 
    1160                 1165                 1170             
Tyr Gly  Ala Ile Lys Asn Pro  Leu Asn Thr Asp Glu  Ile Arg Tyr 
    1175                 1180                 1185             
Val Ile  Arg Lys Asp Leu Glu  Ser Leu Lys Ala Ser  Asp Ile Glu 
    1190                 1195                 1200             
Asn Ile  Val Asp Glu Thr Val  Lys Glu Lys Val Lys  Gln Ala Val 
    1205                 1210                 1215             
Thr Asn  Lys Val Leu Leu Leu  Ser Ser Asn Ala Gln  Gln Lys Asn 
    1220                 1225                 1230             
Lys Ile  Ala Glu Asn Glu Lys  Val Trp Met Asn Lys  Glu Lys Gln 
    1235                 1240                 1245             
Ile Ser  Ile Asn Lys Val Arg  Ile Tyr Ala Asn Ser  Val Lys Asn 
    1250                 1255                 1260             
Pro Leu  Glu Ile Lys Glu His  Ser Leu Leu Ser Lys  Ser Arg His 
    1265                 1270                 1275             
Glu His  Lys Gln Arg Val Tyr  Gly Gln Asn Asp Glu  Asn Tyr Ala 
    1280                 1285                 1290             
Met Ala  Leu Tyr Glu Leu Asp  Gly Lys Arg Glu Phe  Glu Leu Ile 
    1295                 1300                 1305             
Asn Asn  Phe Asn Leu Ala Lys  Leu Ile Lys Asn Gly  Gln Gly Phe 
    1310                 1315                 1320             
Tyr Pro  Leu Asn Lys Glu Lys  Glu Leu Lys Gly Lys  Lys Val Leu 
    1325                 1330                 1335             
Tyr Pro  Ile Ala Lys Ser Asn  Ser Arg Asp Val Val  Leu Lys Arg 
    1340                 1345                 1350             
Gly Gln  Gln Val Val Phe Phe  Asp Lys Glu Val Glu  Lys Pro Lys 
    1355                 1360                 1365             
Asp Ile  Ser Glu Ile Leu Asp  Phe Lys Arg Arg Val  Tyr Ile Ile 
    1370                 1375                 1380             
Glu Gly  Leu Ser Ile Gln Arg  Ile Lys Ser Gly Asn  Asn Glu Phe 
    1385                 1390                 1395             
Glu Tyr  Gly Val Ile Met Leu  Arg Tyr Phe Lys Glu  Ala Arg Lys 
    1400                 1405                 1410             
Ser Asp  Glu Ile Lys Lys Asp  Asn Phe Lys Pro Asp  Gly Val Phe 
    1415                 1420                 1425             
Lys Leu  Gly Glu Asn Lys Pro  Thr Arg Lys Met Asn  His Ser Gln 
    1430                 1435                 1440             
Phe Thr  Ala Phe Val Glu Gly  Ile Asp Phe Lys Val  Leu Pro Ser 
    1445                 1450                 1455             
Gly Lys  Phe Val Lys Ile 
    1460                 

<210>  66
<211>  1458
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Cas-Locus 25

<400>  66
Met Ala Lys Ile Leu Gly Leu Asp Leu Gly Thr Asn Ser Ile Gly Trp 
1               5                   10                  15      
Ala Ile Val Asp Lys Asp Glu Asn Asn Phe Ser Leu Val Asp Lys Gly 
            20                  25                  30          
Val Arg Ile Phe Ser Glu Gly Val Lys Ser Glu Lys Gly Ile Glu Ser 
        35                  40                  45              
Ser Arg Ala Ala Glu Arg Thr Gly Phe Arg Ser Ala Arg Lys Ile Lys 
    50                  55                  60                  
Tyr Arg Arg Lys Leu Arg Lys Tyr Glu Thr Leu Lys Val Leu Ser Ser 
65                  70                  75                  80  
Asn Gly Met Cys Pro Leu Ser Ile Glu Glu Val Glu Asp Trp Lys Lys 
                85                  90                  95      
Ser Gly Phe Lys Gln Tyr Pro Leu Asn Pro Glu Phe Leu Lys Trp Leu 
            100                 105                 110         
Arg Thr Asp Glu Ala Glu Asn Ile Asn Pro Tyr Phe Phe Arg Asp Lys 
        115                 120                 125             
Ala Ser Lys Gln Lys Val Pro Leu Phe Glu Leu Gly Arg Ala Phe Tyr 
    130                 135                 140                 
His Ile Ala Gln Arg Arg Gly Phe Leu Ser Asn Arg Leu Asp Gln Ser 
145                 150                 155                 160 
Ala Glu Gly Ile Leu Glu Glu His Cys Pro Lys Ile Glu Thr Ile Val 
                165                 170                 175     
Glu Asp Leu Asn Ser Tyr Glu Glu Val Leu Glu Asn Leu Lys Asp Tyr 
            180                 185                 190         
Phe Phe Phe Glu Thr Gly Ile Leu Asp Ala Asn Glu Lys Ser Gly Tyr 
        195                 200                 205             
Ala Lys Asp Leu Asp Glu Gly Asp Lys Lys Leu Val Ser Leu Tyr Lys 
    210                 215                 220                 
Ser Leu His Thr Ile Val Lys Lys Asn Asp Thr Asn Phe Glu Lys Gly 
225                 230                 235                 240 
Lys Ala Glu Ile Ile Glu Arg Leu Asn Lys Lys Asp Val Leu Gly Lys 
                245                 250                 255     
Val Lys Gly Lys Ile Lys Asp Ile Ser Gln Ala Met Val Asp Gly Ser 
            260                 265                 270         
Phe Lys Thr Leu Gly Gln Tyr Phe Phe Ser Leu Tyr Ser Lys Glu Lys 
        275                 280                 285             
Ile Arg Asn Gln Tyr Thr Ser Arg Glu Glu His Tyr Leu Glu Glu Phe 
    290                 295                 300                 
Ile Thr Ile Cys Lys Val Gln Gly Ile Asp Ser Ile Asn Glu Lys Glu 
305                 310                 315                 320 
Gln Leu Pro Glu Lys Lys Ser Asp Gly Leu Ala Lys Asp Leu Tyr Lys 
                325                 330                 335     
Ala Ile Phe Phe Gln Arg Pro Leu Lys Ser Gln Lys Gly Leu Ile Gly 
            340                 345                 350         
Lys Cys Ser Phe Glu Lys Ser Lys Ser Arg Cys Ser Val Ser His Pro 
        355                 360                 365             
Asp Phe Glu Glu Tyr Arg Met Trp Asn Tyr Ile Asn Thr Ile Lys Ile 
    370                 375                 380                 
Gly Thr Gln Ser Glu Lys Thr Leu Arg Phe Leu Thr Gln Glu Glu Lys 
385                 390                 395                 400 
Leu Lys Leu Val Pro Lys Phe Tyr Arg Lys Asn Asp Phe Asn Phe Glu 
                405                 410                 415     
Val Leu Ala Lys Glu Leu Ile Glu Lys Gly Thr Ser Phe Gly Phe Tyr 
            420                 425                 430         
Lys Ser Ser Lys Lys Asn Asp Tyr Phe Tyr Trp Phe Asn Phe Lys Pro 
        435                 440                 445             
Thr Asp Ser Val Ser Ala Cys Gln Val Ser Ala Ser Leu Lys Asn Ile 
    450                 455                 460                 
Ile Gly Glu Asp Trp Lys Thr Lys Thr Phe Thr Tyr Gln Thr Leu Asn 
465                 470                 475                 480 
Val Lys Lys Glu Glu Val Thr Lys Thr Val Asp Tyr Lys Asp Leu Trp 
                485                 490                 495     
His Leu Leu Ser Val Ala Thr Ser Asp Ile Tyr Leu Asn Lys Tyr Ala 
            500                 505                 510         
Lys Asp Lys Leu Gly Phe Glu Asp Lys Asn Ala Lys Ala Phe Ser Lys 
        515                 520                 525             
Ile Lys Leu Lys Lys Asp Phe Gly Asn Leu Ser Leu Ser Ala Ile Thr 
    530                 535                 540                 
Lys Ile Leu Pro Tyr Ile Lys Glu Gly Leu Leu Tyr Ser His Ala Val 
545                 550                 555                 560 
Phe Met Ala Asn Ile Glu Asn Ile Val Asp Glu Glu Ile Trp Lys Asp 
                565                 570                 575     
Glu His Gln Arg Lys Tyr Ile Gln Thr Gln Ile Ala Glu Ile Val Glu 
            580                 585                 590         
Asn Tyr Thr Phe Glu Lys Ser Gln Leu Glu Val Ile Asn Gly Leu Ile 
        595                 600                 605             
Lys Asp Ser Lys Leu Lys Glu Glu Tyr Tyr Ser Lys Glu Ala Glu Ser 
    610                 615                 620                 
Ile Tyr Lys Lys Asp Leu Ala Thr Lys Leu Val Leu Phe Phe Lys Tyr 
625                 630                 635                 640 
Asn Val Ile Glu Asn Glu Ser Asp Gln Lys Ile Ile Phe Glu Asn Leu 
                645                 650                 655     
Phe Pro Ile Phe Ile Glu Gln Leu Lys Lys Tyr Glu Phe Ile Lys Ile 
            660                 665                 670         
Gln Arg Leu Asp Glu Lys Val Leu Glu Phe Leu Lys Gly Glu Asn Gln 
        675                 680                 685             
Asp Gly Glu Ile Phe Cys Ser Asn Pro Lys Gln Leu Lys Lys Leu Tyr 
    690                 695                 700                 
His Pro Ser Asp Ile Glu Val Phe Lys Lys Lys Ile Ile Lys Asp Glu 
705                 710                 715                 720 
Phe Gly Asn Glu Lys Val Val Leu Gly Thr Pro Leu Thr Ser Ala Ile 
                725                 730                 735     
Lys Asn Pro Met Ala Met Arg Ala Leu His Gln Leu Arg Lys Val Leu 
            740                 745                 750         
Asn Thr Leu Ile Leu Glu Gly Leu Val Asp Glu Asn Thr Leu Ile His 
        755                 760                 765             
Ile Glu Met Ala Arg Glu Leu Asn Asp Ala Asn Lys Arg Lys Gly Ile 
    770                 775                 780                 
Gln Asp Tyr Gln Asn Glu Asn Lys Lys Phe Arg Glu Asp Ala Ile Lys 
785                 790                 795                 800 
Glu Ile Lys Lys Leu Tyr Leu Asp Glu Cys Lys Lys Glu Val Glu Pro 
                805                 810                 815     
Thr Glu Asp Asp Ile Leu Arg Tyr Gln Leu Trp Ile Glu Gln Asn Arg 
            820                 825                 830         
Gln Glu Ile Tyr Glu Gln Gly Lys Asn Ile Ser Ile Cys Asp Ile Ile 
        835                 840                 845             
Gly Ser Asn Pro Ala Tyr Asp Ile Glu His Thr Ile Pro Arg Ser Arg 
    850                 855                 860                 
Ser Gln Asp Asn Ser Gln Met Asn Lys Thr Leu Cys Ser Gln Arg Phe 
865                 870                 875                 880 
Asn Arg Glu Ile Lys Gly Asn Lys Met Pro Ile Glu Leu Asn Asn His 
                885                 890                 895     
Leu Glu Ile Leu Pro Arg Ile Ala His Trp Lys Glu Glu Ala Ser Asn 
            900                 905                 910         
Leu Ser Arg Glu Ile Glu Ile Ile Ser Arg Ser Ile Lys Ala Ala Ala 
        915                 920                 925             
Thr Lys Glu Val Lys Asp Lys Lys Ile Arg Arg Arg His Tyr Leu Thr 
    930                 935                 940                 
Leu Lys Arg Asp Tyr Leu Gln Gly Lys Tyr Asp Arg Phe Ile Leu Glu 
945                 950                 955                 960 
Glu Pro Arg Val Gly Phe Lys Asn Ser Gln Ile Pro Asp Thr Gly Ile 
                965                 970                 975     
Ile Thr Lys Tyr Ser Gln Ala Tyr Leu Lys Ser Tyr Phe Lys Arg Val 
            980                 985                 990         
Glu Ser Val Lys Gly Gly Met Val  Ala Glu Phe Arg Lys  Gln Trp Gly 
        995                 1000                 1005             
Ile Gln  Glu Ser Phe Ile Asp  Glu Asn Gly Phe Lys  His Tyr Lys 
    1010                 1015                 1020             
Ile Lys  Asp Arg Ser Lys His  Thr His His Thr Ile  Asp Ala Ile 
    1025                 1030                 1035             
Thr Ile  Ala Cys Met Thr Lys  Asp Lys Tyr Asp Val  Leu Ala His 
    1040                 1045                 1050             
Ala Trp  Ala Leu Glu Asp Glu  Gln Asn Lys Lys Glu  Ala Lys Ala 
    1055                 1060                 1065             
Ile Ile  Glu Lys Ala Lys Pro  Trp Lys Thr Phe Lys  Glu Asp Leu 
    1070                 1075                 1080             
Leu Lys  Ile Glu Glu Glu Ile  Leu Val Ser His Tyr  Thr Pro Asp 
    1085                 1090                 1095             
Asn Val  Lys Lys Gln Ser Lys  Lys Val Ile Arg Ile  Arg Gly Lys 
    1100                 1105                 1110             
Lys Gln  His Val Ala Glu Ile  Glu Arg Asp Glu Lys  Gly Lys Ala 
    1115                 1120                 1125             
Ile Pro  Lys Lys Asp Ala Asn  Gly Lys Ile Leu Tyr  Lys Leu Asp 
    1130                 1135                 1140             
Lys Glu  Gly Lys Lys Leu Pro  Arg Tyr Gln Gln Gly  Asp Ala Ile 
    1145                 1150                 1155             
Arg Gly  Ser Leu His Gln Asp  Ser Ile Tyr Gly Ala  Ile Lys Asn 
    1160                 1165                 1170             
Pro Leu  Asn Thr Glu Glu Ile  Arg Tyr Val Ile Arg  Lys Asp Leu 
    1175                 1180                 1185             
Glu Ser  Leu Lys Ala Ser Asp  Ile Glu Asn Ile Val  Asp Glu Thr 
    1190                 1195                 1200             
Val Lys  Glu Lys Ile Lys Glu  Ala Val Ala Asn Lys  Val Leu Leu 
    1205                 1210                 1215             
Phe Ser  Ser Asn Ala Gln Gln  Lys Asn Lys Ile Arg  Glu Asn Glu 
    1220                 1225                 1230             
Lys Val  Trp Met Asn Glu Glu  Lys Gln Val Pro Ile  Asn Lys Val 
    1235                 1240                 1245             
Arg Ile  Tyr Ala Asn Ser Val  Lys Asn Pro Leu Glu  Val Lys Glu 
    1250                 1255                 1260             
His Ser  Leu Leu Ser Lys Ser  Arg His Glu His Lys  Gln Lys Val 
    1265                 1270                 1275             
Tyr Gly  Gln Asn Asp Glu Asn  Tyr Cys Met Ala Ile  Tyr Glu Leu 
    1280                 1285                 1290             
Glu Gly  Lys Arg Glu Phe Glu  Leu Ile Asn Asn Phe  Asn Leu Ala 
    1295                 1300                 1305             
Lys Leu  Ile Lys Gly Gly Gln  Gly Phe Tyr Pro Phe  Tyr Lys Glu 
    1310                 1315                 1320             
Lys Glu  Val Lys Gly Lys Val  Val Gln Val Pro Ile  Ala Lys Arg 
    1325                 1330                 1335             
Asn Gly  Arg Asp Leu Ile Leu  Lys Arg Gly Gln Gln  Val Ile Phe 
    1340                 1345                 1350             
Tyr Asp  Lys Asp Val Glu Asn  Pro Asp Asp Val Phe  Asp Leu Val 
    1355                 1360                 1365             
Asp Leu  Lys Gly Arg Ile Tyr  Ile Ile Glu Gly Leu  Ser Ile Gln 
    1370                 1375                 1380             
Arg Gln  Val Val Ser Gly Lys  Leu Tyr Glu Phe Gly  Ser Ile Met 
    1385                 1390                 1395             
Phe Arg  Tyr Phe Lys Glu Ala  Arg Lys Ala Asp Glu  Ile Lys Lys 
    1400                 1405                 1410             
Asp Ser  Phe Lys Pro Asp Gly  Thr Phe Lys Ser Gly  Glu Ile Lys 
    1415                 1420                 1425             
Pro Thr  Arg Lys Met Asn His  Asn Gln Phe Thr Ala  Phe Val Glu 
    1430                 1435                 1440             
Gly Ile  Asp Phe Lys Val Leu  Pro Ser Gly Lys Phe  Ile Lys Ile 
    1445                 1450                 1455             

<210>  67
<211>  1127
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Cas-Locus 26

<400>  67
Met Ala Lys Ile Leu Gly Leu Asp Leu Gly Thr Asn Ser Ile Gly Trp 
1               5                   10                  15      
Ala Leu Ile Asp Asp Lys Leu Asn Lys Ile Leu Gly Ile Gly Ser Arg 
            20                  25                  30          
Ile Phe Pro Met Gly Val Glu Asn Leu Gly Asp Gly Asp Asn Glu Met 
        35                  40                  45              
Ser Lys Asn Ala Ser Arg Thr Gly Ala Arg Gly Val Arg Arg Gln Phe 
    50                  55                  60                  
Phe Arg Arg Arg Leu Arg Lys Lys Val Leu Leu Lys Ser Leu Ser Glu 
65                  70                  75                  80  
Asn Asn Met Cys Pro Ile Asn Thr Lys Asp Phe Glu Asp Trp Lys Gln 
                85                  90                  95      
Thr Lys Gln Phe Pro Asn Glu Lys Leu Ala Thr Trp Phe Ala Met Asn 
            100                 105                 110         
Pro Tyr Glu Leu Arg Gln Lys Ala Leu Thr Glu Lys Leu Ser Leu Glu 
        115                 120                 125             
Glu Ile Gly Arg Ile Phe Tyr His Leu Ile Gln Arg Arg Gly Phe Leu 
    130                 135                 140                 
Ser Asn Ser Arg Lys Gly Gly Ser Asp Asp Gly Ala Ile Phe Lys Gly 
145                 150                 155                 160 
Asn Ala Lys Glu Gly Lys Ile Gly Ile Asp Tyr Thr Leu Glu Ser Ile 
                165                 170                 175     
Glu Gly Lys Thr Leu Gly Ser Tyr Leu Tyr Glu Ile Tyr Pro Lys Glu 
            180                 185                 190         
Asn Gln Pro Phe Gln Tyr Gly Leu Glu Arg Ile Arg Asn Arg Tyr Thr 
        195                 200                 205             
Thr Arg Arg Met Tyr Ile Asp Glu Phe Glu Met Ile Trp Asn Lys Gln 
    210                 215                 220                 
Ser Glu Phe His Ser Val Leu Asn Tyr Asp Leu Lys Thr Ile Leu Gly 
225                 230                 235                 240 
Gly Arg Lys Gln Asp Asn Tyr Thr Glu Asp Gly Ile Leu Phe Tyr Gln 
                245                 250                 255     
Arg Pro Leu Arg Ser Gln Lys His Leu Val Gly Asn Cys Ser Phe Glu 
            260                 265                 270         
Pro Leu Lys Thr Lys Cys Pro Ile Ser Ala Ile Pro Val Glu Met Phe 
        275                 280                 285             
Arg Ile Trp Gln Trp Val Asn Thr Val Glu Tyr Asn Gly Lys Lys Ile 
    290                 295                 300                 
Ser Glu Glu Glu Lys Thr Lys Leu Val Glu Gln Leu Leu Ser Phe Asp 
305                 310                 315                 320 
Lys Ile Glu Phe Lys Lys Leu Arg Lys Ala Ile Gly Lys Glu Ser Ala 
                325                 330                 335     
Glu Phe Lys Phe Asn Tyr Lys Asp Asp Asp Lys Ile Ala Gly Thr His 
            340                 345                 350         
Thr Ile Ser Asn Leu Ser Asn Arg Lys Phe Phe Gly Lys Arg Trp Phe 
        355                 360                 365             
Asp Phe Ser Asp Lys Glu Gln Glu Asp Ile Trp His Val Leu Tyr Phe 
    370                 375                 380                 
Phe Asp Ser Lys Ser Asn Leu Lys Glu Tyr Ala Val Lys Asn Trp Asn 
385                 390                 395                 400 
Phe Ser Glu Glu Gln Ala Ile Ala Ile Ser Arg Phe Asn Val Lys Asp 
                405                 410                 415     
Gly Tyr Ala Ser Leu Ser Arg Lys Ala Ile Gly Asn Ile Leu Pro Phe 
            420                 425                 430         
Leu Gln Gln Gly Tyr Thr Tyr Asp Ile Ala Val Val Met Gly Gly Ile 
        435                 440                 445             
Lys Asn Ala Phe Gly Asp Lys Trp Gln Asn Asp Thr Val Glu Asn Lys 
    450                 455                 460                 
Leu Lys Gln Leu Asp Leu Ile Asp Asn Ile Glu Gly Ile Val Arg Ser 
465                 470                 475                 480 
Lys Ile Ser Gly Gly Phe Ile Asp Thr Ile Lys Asp Leu Leu Arg Lys 
                485                 490                 495     
Glu Phe Glu Phe Asn Asp Lys Gln Leu Lys Lys Leu Tyr His His Ser 
            500                 505                 510         
Ala Ala Ile Asp Thr Val Ala Leu Leu Arg Lys Leu Pro Thr Gly Lys 
        515                 520                 525             
Gln Ala Asp Lys Asp Ile Gln Ala Ile Arg Asn Pro Ile Val Ile Thr 
    530                 535                 540                 
Ala Leu Phe Glu Leu Arg Lys Leu Val Asn Glu Leu Ile Glu Glu His 
545                 550                 555                 560 
Gly Gln Leu Asp Glu Ile Lys Val Glu Met Ala Arg Asp Leu Lys Ile 
                565                 570                 575     
Ser Lys Ser Gln Arg Asn Lys Ile Arg Lys Asp Gln Lys Arg Leu Glu 
            580                 585                 590         
Arg Glu Asn Asp Arg Val Lys Lys Glu Val Glu Lys Tyr Val Arg Val 
        595                 600                 605             
Ser His Asp Asn Ile Leu Arg Phe Lys Leu Trp Glu Glu Cys Lys Gln 
    610                 615                 620                 
Thr Cys Pro Tyr Thr Gly Val Val Ile Pro Val Thr Lys Leu Phe Thr 
625                 630                 635                 640 
Gly Glu Ile Gln Ile Glu His Ile His Pro Trp Ser Arg Ser Leu Asn 
                645                 650                 655     
Asp Ser Phe Asn Asn Lys Thr Leu Cys Tyr Ala Asp Glu Asn Arg Arg 
            660                 665                 670         
Lys Gly Asp Lys Thr Pro Phe Glu Phe Tyr Gly Ser Asp Glu Leu Asp 
        675                 680                 685             
Trp Ile Ala Arg Lys Glu Arg Ala Leu Lys Leu Phe Ser Asp Thr Lys 
    690                 695                 700                 
Glu Tyr Pro Asn Ala Tyr Gln Lys Phe Lys Arg Phe Val Gln Gln Lys 
705                 710                 715                 720 
Phe Asp Asp Asp Phe Ser Ser Arg Gln Leu Asn Asp Thr Arg Phe Ile 
                725                 730                 735     
Ser Lys Glu Ala Ser Ser Tyr Leu Lys Gln Ile Cys Glu Lys Val Asn 
            740                 745                 750         
Val Ser Pro Gly Gln Met Thr Ala Asn Leu Arg Gln Lys Trp Gly Leu 
        755                 760                 765             
Asn Thr Val Leu Asn Asp Glu Asn Ala Lys Thr Arg Glu Asp His Arg 
    770                 775                 780                 
His His Ala Ile Asp Ala Leu Val Met Ala Cys Gly Lys Thr Ser Tyr 
785                 790                 795                 800 
Leu Gln Glu Leu Ser Lys Trp Asn Arg Tyr Asn Arg Asn Tyr Asp Leu 
                805                 810                 815     
Lys Asp Phe Pro Met Pro Trp Glu Thr Phe Arg Phe Asp Ala Glu Lys 
            820                 825                 830         
Ala Ile Asp Lys Ile Leu Ile Ser His Lys Arg Ile Ser Asn Asp Ile 
        835                 840                 845             
Thr Thr Arg Tyr Thr Lys Val Glu Lys Asn Gly Lys Thr Tyr Ile Asn 
    850                 855                 860                 
Lys Gly Val Ala Ala Arg Gly Gln Leu His Lys Glu Thr Val Phe Gly 
865                 870                 875                 880 
Lys Arg Asn Phe Asn Gly Asp Glu Ala Phe His Val Arg Lys Ser Ile 
                885                 890                 895     
Asp Ser Leu Thr Thr Glu Lys Gln Leu Glu Lys Val Val Asp Glu Val 
            900                 905                 910         
Ile Lys Lys Leu Ile His Lys Lys Ile Lys Glu Leu Gly Gly Phe Val 
        915                 920                 925             
Lys Gly Thr Ile Pro Ala Asn Thr Phe Phe Asn Val Asp Glu Asn Gly 
    930                 935                 940                 
Val Lys Gln Pro Gln Ile Phe Leu Pro Asn Lys Asn Gly Ser Pro Val 
945                 950                 955                 960 
Pro Ile Leu Lys Val Arg Met Lys Glu Asn Ile Ser Gly Ala Glu Lys 
                965                 970                 975     
Leu Lys Asp Asn Val Asn Gln Trp Val Asn Pro Arg Asn Asn His His 
            980                 985                 990         
Val Leu Ile Tyr Lys Asp Glu Lys  Gly Ile Leu Arg Glu  Glu Val Val 
        995                 1000                 1005             
Thr Phe  Trp Thr Val Val Glu  Arg Lys Ser Lys Gly  Phe Pro Val 
    1010                 1015                 1020             
Tyr Gln  Leu Pro Val Glu Gly  Lys Glu Ile Val Thr  Ala Leu His 
    1025                 1030                 1035             
Ile Asn  Asp Met Phe Leu Leu  Gly Leu Asn Glu Glu  Glu Ile Asn 
    1040                 1045                 1050             
Trp Glu  Asn Pro Asp Tyr Glu  Ile Leu Arg Asp Ser  Leu Tyr Arg 
    1055                 1060                 1065             
Val Gln  Ser Leu Ser Ser Lys  Tyr Tyr Glu Phe Arg  Gln Ser Ile 
    1070                 1075                 1080             
Asn Ala  Glu Ser Gln Asn Lys  Ile Ser Pro Ile Tyr  Glu Gln Ile 
    1085                 1090                 1095             
Arg Gly  Phe Gly Ser Gly Lys  Thr Gly Trp Asp Ser  Phe Asn Pro 
    1100                 1105                 1110             
Ile Lys  Val Lys Ile Ser Val  Ser Gly Lys Ile Ser  Lys Ile 
    1115                 1120                 1125         

<210>  68
<211>  1108
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Cas-Locus 27

<400>  68
Met Ala Tyr Lys Leu Gly Ile Asp Leu Gly Thr Ala Ser Ile Gly Ala 
1               5                   10                  15      
Val Ala Ile Arg Ile Glu Asn Asn Glu Pro Gln Ser Ile Asp Trp His 
            20                  25                  30          
Ala Val Arg Ile Tyr Ser Glu Pro Val Val Asn Thr Pro Lys Gly Leu 
        35                  40                  45              
Gln Pro Lys Lys Ala Ala Arg Arg Asp Ala Arg Gln Leu Arg Lys Gln 
    50                  55                  60                  
Ile Glu Arg Arg Ala Arg Arg Leu Arg Arg Ile Ala Asn Leu Ile Pro 
65                  70                  75                  80  
Leu Leu Gly Leu His Lys Ala Glu Val Lys Pro Gly Arg Arg Gln Asp 
                85                  90                  95      
Leu Thr Thr Leu Arg Ala Ile Ala Ala Arg Gln Gln Val Glu Leu Asn 
            100                 105                 110         
Glu Phe Ala Leu Val Leu Leu Arg Leu Ala Lys Arg Arg Gly Tyr Ala 
        115                 120                 125             
Gly Gly Phe Arg Asp Ser Lys Asp Gly Val Val Lys Ser Ser Ser Asp 
    130                 135                 140                 
Lys Leu Ser Glu Glu Met Arg Arg Leu Ala Glu Thr Gln Asn Leu Gln 
145                 150                 155                 160 
Glu Ile Thr Leu Gly Glu Tyr Leu Leu Tyr Arg Gln Glu His Gly Leu 
                165                 170                 175     
Pro Val Trp Leu Lys Ala Glu Arg Pro Gly Leu Glu Pro Arg Tyr Ala 
            180                 185                 190         
Leu Arg Glu Met Val Thr Ala Glu Phe Glu Gln Leu Trp Thr Thr Gln 
        195                 200                 205             
Ala Arg Tyr His Pro Ile Leu Ala Ser Asn His Leu Gly Lys Pro Leu 
    210                 215                 220                 
Lys Gln Trp Phe Asn Glu Ala Leu Phe Tyr Gln Arg Pro Leu Lys Ser 
225                 230                 235                 240 
Pro Ala His Met Val Gly Asn Cys Leu Leu Glu Pro Asn Leu Pro Arg 
                245                 250                 255     
Ala Pro Arg Ala His Met Ala Ala Gln His Phe Arg Ile Asp Lys Thr 
            260                 265                 270         
Leu His Asp Met Arg Trp Gly Ser Gly Arg Arg Ala Glu Arg Leu Ser 
        275                 280                 285             
Lys Ala Gln Leu Asn Val Leu Arg Gln Met Leu Asn Asp Pro Ala Asn 
    290                 295                 300                 
Ala Asp Gly Lys Val Ser Phe Lys His Leu Tyr Gln Ala Leu Ser Glu 
305                 310                 315                 320 
Thr Gly Leu Ser Asp Pro Arg Ser Arg Thr Leu Asn Leu Glu Arg Ser 
                325                 330                 335     
Ser Cys Asp Gln Leu Ser Gly Asn Asn Thr Val Ala Arg Trp Arg Ala 
            340                 345                 350         
Leu Gly Leu Tyr Asp Gln Trp Leu Thr Leu Ala Pro Arg Asp Gln Thr 
        355                 360                 365             
Thr Ile Ile Asn Leu Leu Ala Asp Leu Gly Gly Pro Glu Leu Leu Val 
    370                 375                 380                 
Pro Asp Asp Trp His Gln Asn Ile Arg Lys Ser Ser Ala Lys Ala Gly 
385                 390                 395                 400 
Asp Thr Asn Leu Tyr Arg Arg Phe Arg Pro Glu Val Val Asp Phe Ile 
                405                 410                 415     
Asn Ala Leu Arg Glu Cys Lys Asp Asn Asn Gly Gln Pro Val Phe Asn 
            420                 425                 430         
Arg Leu Thr Ser Met Lys Phe Glu Gly Gly Arg Ser Ser Tyr Ser Val 
        435                 440                 445             
Lys Ala Leu Glu Lys Leu Asn Thr Trp Phe Asn Asp Pro Trp Trp Pro 
    450                 455                 460                 
Asp Glu Gly Ser Gly Ala Glu Arg Gly Asp Glu Ile Asp Glu Asp Ala 
465                 470                 475                 480 
Ala Leu Arg Val Cys Tyr Pro His Leu Phe Thr Gln Pro Gln Glu Leu 
                485                 490                 495     
Leu Gln Arg Leu Glu Ala Ala Pro Thr Thr Gly Asn Asp Val Val Asp 
            500                 505                 510         
Gly Ala Leu Arg Glu Leu Arg Lys Val Ile Asn Gln Cys Ile Asp Ala 
        515                 520                 525             
Leu Gly Glu Arg Pro Glu Glu Ile Val Val Glu Met Ala Arg Glu Ile 
    530                 535                 540                 
Gly Lys Gly Val Val Trp Arg Lys Glu Gln Glu Asn Arg Ile Arg Gln 
545                 550                 555                 560 
Asn Glu Leu Ala Arg Arg Lys Ile Ala Ser Glu Leu Glu Lys His Gly 
                565                 570                 575     
Leu Ser Ala Asn Asn Thr Arg Ile Leu Arg Tyr Gln Leu Trp Glu Glu 
            580                 585                 590         
Gln Asp Leu His Trp Cys Pro Tyr Cys Ala His Pro Ile Asn Leu Glu 
        595                 600                 605             
Ala Ala Thr Ser Gly Met Thr His Ile Glu His Val Leu Pro Arg Ser 
    610                 615                 620                 
Leu Thr Gln Ile Gly Arg Lys Arg Ser Glu Leu Val Leu Ala His Ala 
625                 630                 635                 640 
Gly Cys Asn Asn Leu Lys Ala Asp Gln Thr Pro Trp Gln Ala Phe Gly 
                645                 650                 655     
His Asp Val Glu Arg Trp Ser Ala Val Glu Arg Ala Ala Ala Arg Phe 
            660                 665                 670         
Gln Glu Leu Gly Lys Lys Ser Tyr Ala Lys Asp Arg Ile Lys Ala Met 
        675                 680                 685             
Gly Phe Tyr Arg Lys Ala Glu Leu Leu Leu Leu Lys Asp Tyr Glu Ser 
    690                 695                 700                 
Glu Val Leu Ser Asp Glu Ser Ile Ala Asp Phe Ala Asp Arg Gln Leu 
705                 710                 715                 720 
His Gln Thr Ser Trp Ile Ala Lys Ala Ala Ala Gln Trp Leu Arg Thr 
                725                 730                 735     
Ile Thr Pro Leu Val Ser Val Ser Arg Gly Glu Phe Thr Ala Leu Leu 
            740                 745                 750         
Arg His Gln Trp Arg Leu Asp Thr Val Ile Ala Glu Ala Arg Leu Asp 
        755                 760                 765             
Glu Lys Leu Pro Val Leu Asp Ile Asp Ala Cys Pro Val Ser Pro Glu 
    770                 775                 780                 
Ala Phe Gln Gln Phe Arg Lys Gln Trp Glu Gly His Pro Pro Asp Asn 
785                 790                 795                 800 
Leu Ala Glu Arg Thr Glu Arg Lys Leu Glu Lys Arg Leu Asp His Arg 
                805                 810                 815     
His His Gly Ile Asp Ala Leu Val Ile Ala Leu Thr Ser Arg Ser Leu 
            820                 825                 830         
Tyr Met Ser Leu Ala Arg Arg Tyr Val Glu Glu Ser Glu Arg Arg Ala 
        835                 840                 845             
Arg Gly Glu Arg Val Arg His Asp Trp Ser Ile Glu Pro Thr Met His 
    850                 855                 860                 
Asn Leu Arg Asn Gln Ala Leu Gly Met Val Arg Thr Cys Asn Leu Thr 
865                 870                 875                 880 
His Lys Pro Asp Arg Asn Pro Ala Gly Arg Leu Phe Lys Asp Thr Ala 
                885                 890                 895     
Tyr Gly Val His Phe Pro Glu Glu Gly Asp Arg Val Gln Leu Thr Leu 
            900                 905                 910         
Arg Lys Pro Leu Thr Ser Leu Ala Asp Glu Lys Ser Ala Glu Lys Thr 
        915                 920                 925             
Arg Lys Asn Leu His Ser Ile Ala Ser Ser Glu Val Arg Leu Leu Val 
    930                 935                 940                 
Leu Lys Ala Phe Glu Ala Arg Leu Ser Val Gly Gln Asn Pro Lys Gln 
945                 950                 955                 960 
Ala Leu Ser Glu Pro Val Pro Tyr Pro Ala Tyr Gly Thr Ala Ile Trp 
                965                 970                 975     
Arg Val Arg Cys Met Gln Gly Tyr Ala Asp Asp Ala Val Arg Ile Val 
            980                 985                 990         
His Lys Ser Arg Gln Gly Glu His  Glu Lys His Leu Leu  Asn Asp Gly 
        995                 1000                 1005             
Tyr Ala  Cys Leu Glu Ile Thr  Ala Gly Glu Asn Gly  Lys His Gln 
    1010                 1015                 1020             
Val Arg  Leu Val Thr Gln Arg  Glu Ala Gln Gly Arg  Gly Phe Met 
    1025                 1030                 1035             
Asp Asn  Arg Gln Gln Ala Lys  Arg Ile Phe Lys Gly  Asp Thr Val 
    1040                 1045                 1050             
Ile Asp  Arg Arg Asp Asp Arg  Lys Tyr Leu Val Gly  Tyr Phe Lys 
    1055                 1060                 1065             
Ala Glu  Gly Tyr Ile Phe Leu  Leu Pro His Thr Asp  Thr Arg Asn 
    1070                 1075                 1080             
Phe Asp  Lys Ile Lys Glu Ala  Asp Ser Gly Lys Lys  Lys Val Ser 
    1085                 1090                 1095             
Phe Asn  Gln Ala Tyr Gln Leu  Glu Arg Ile 
    1100                 1105             

<210>  69
<211>  1108
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Cas-Locus 28

<400>  69
Met Ala Tyr Lys Leu Gly Ile Asp Leu Gly Thr Ala Ser Ile Gly Ala 
1               5                   10                  15      
Val Ala Ile Arg Ile Glu Asn Lys Val Pro Ile Ser Val Asp Trp His 
            20                  25                  30          
Ala Val Arg Ile Phe Ser Glu Pro Val Val Asn Thr Gln Lys Gly Leu 
        35                  40                  45              
Thr Pro Lys Lys Thr Ala Arg Arg Glu Ala Arg Gln Leu Arg Lys Gln 
    50                  55                  60                  
Val Glu Arg Arg Ala Arg Arg Leu Arg Arg Ile Ala Asn Leu Ile Pro 
65                  70                  75                  80  
Leu Leu Gly Leu Gln Lys Ala Glu Val Lys Leu Gly Arg Arg Gln Asp 
                85                  90                  95      
Leu Thr Thr Leu Arg Ala Ile Ala Ala Arg Glu Lys Val Glu Leu His 
            100                 105                 110         
Glu Phe Ala Leu Val Leu Leu Arg Ile Ala Lys Arg Arg Gly Tyr Ala 
        115                 120                 125             
Gly Gly Phe Arg Asp Ser Glu Gly Gly Val Val Lys Thr Ala Ser Asp 
    130                 135                 140                 
Lys Leu Ser Val Glu Met Arg Ala Leu Ala Glu Thr Arg Gly Leu Gln 
145                 150                 155                 160 
Gln Ile Thr Leu Gly Glu Tyr Leu Leu His Arg Gln Gln Arg Gly Leu 
                165                 170                 175     
Pro Ile Trp Leu Lys Ala Glu Arg Pro Gly Leu Glu Pro Leu Tyr Ala 
            180                 185                 190         
Leu Arg Glu Met Val Thr Ala Glu Phe Glu Gln Ile Trp Thr Ile Gln 
        195                 200                 205             
Ala Lys Cys His Pro Ile Leu Asn Ser Cys His Leu Glu Lys Pro Leu 
    210                 215                 220                 
Lys Gln Trp Phe Tyr Gln Ala Leu Phe Tyr Gln Arg Pro Leu Lys Ser 
225                 230                 235                 240 
Pro Ala His Met Val Gly Asn Cys Leu Leu Glu Pro Asn Leu Pro Arg 
                245                 250                 255     
Ala Pro Arg Ala Gln Met Ala Ala Gln Arg Phe Arg Ile Glu Lys Thr 
            260                 265                 270         
Leu His Asp Leu Arg Trp Gly Gly Gly Arg Gln Ala Glu Arg Leu Asn 
        275                 280                 285             
Thr Ala Gln Leu Asp Leu Leu Arg Gln Thr Leu Ser Asp Pro Thr Asn 
    290                 295                 300                 
Val Asp Ser Lys Val Ser Phe Lys Arg Leu Tyr Gln Ala Leu Asn Glu 
305                 310                 315                 320 
Ala Gly Leu Asn Asp Pro Arg Asn Arg Thr Leu Asn Leu Glu Arg Ser 
                325                 330                 335     
Ser Arg Asp Gln Leu Leu Gly Asn Ser Thr Val Ala Arg Trp Arg Ala 
            340                 345                 350         
Leu Gly Leu Gln Asp Gln Trp Leu Met Leu Ala Pro Arg Asp Gln Thr 
        355                 360                 365             
Ser Val Ile Asn Leu Leu Ala Asp Leu Gly Gly Pro Glu Ile Leu Thr 
    370                 375                 380                 
Pro Asp Asp Trp His Gln Asn Ile Arg Lys Ser Ser Ala Lys Asp Asp 
385                 390                 395                 400 
Asn Thr Lys Ala Tyr Arg Arg Phe Arg Gln Glu Val Ile Asp Phe Ile 
                405                 410                 415     
Asp Ala Leu Arg Arg Cys Ile Asp Ser Asn Gly Gln Pro Val Phe Asn 
            420                 425                 430         
Arg Leu Ser Ala Met Lys Phe Asp Gly Gly Arg Ser Ser Tyr Ser Val 
        435                 440                 445             
Lys Ala Leu Glu Lys Met Asn Glu Trp Phe Asn Asn Pro Trp Trp Pro 
    450                 455                 460                 
Asn Glu Gly Pro Gly Ser Glu Arg Arg Gly Glu Ile Asp Glu Glu Val 
465                 470                 475                 480 
Ala Ile Arg Val Cys Tyr Pro His Leu Tyr Thr Gln Ser Gln Glu Leu 
                485                 490                 495     
His Pro Arg Leu Glu Ala Ala Pro Thr Thr Gly Asn Asp Val Val Asp 
            500                 505                 510         
Gly Ala Leu Arg Glu Leu Arg Lys Val Ile Asn Gln Cys Ile Asp Glu 
        515                 520                 525             
Gln Gly Glu Lys Pro Gln Glu Ile Ile Ile Glu Leu Ala Arg Glu Val 
    530                 535                 540                 
Gly Lys Gly Val Ala Leu Arg Asn Glu Gln Glu Ser Arg Ile Arg Asn 
545                 550                 555                 560 
Asn Glu Leu Ala Arg Arg Lys Ile Ala Ser Glu Leu Glu Gly His Gly 
                565                 570                 575     
Leu Ile Ala Ser Ser Thr Arg Ile Leu Arg Tyr Gln Leu Trp Glu Glu 
            580                 585                 590         
Gln Glu Arg His Trp Cys Pro Tyr Cys Ala Leu Pro Ile Ser Leu Glu 
        595                 600                 605             
Ala Ala Ile Ser Asn Met Thr His Ile Glu His Val Leu Pro Arg Ser 
    610                 615                 620                 
Leu Thr Gln Val Gly Arg Lys Arg Ser Glu Leu Val Leu Ala His Ala 
625                 630                 635                 640 
Gly Cys Asn His Leu Lys Ala Asp Gln Thr Pro Trp Gln Ala Phe Gly 
                645                 650                 655     
His Asp Ala Glu Arg Trp Ser Ala Val Glu Arg Ala Ala Ala Arg Phe 
            660                 665                 670         
Gln Glu Leu Gly Lys Lys Cys Tyr Phe Lys Asp Arg Ala Lys Ala Met 
        675                 680                 685             
Gly Cys Phe Arg Lys Ser Ala Leu Leu Met Leu Lys Asp Tyr Glu Ser 
    690                 695                 700                 
Glu Val Leu Asn Asp Glu Ser Ile Ala Gly Phe Ala Asn Arg Gln Leu 
705                 710                 715                 720 
His Gln Thr Ser Trp Ile Ala Lys Val Ala Ala Gln Trp Leu Arg Thr 
                725                 730                 735     
Ile Ser Pro Leu Ile Ser Val Ser Arg Gly Glu Phe Thr Ala Leu Leu 
            740                 745                 750         
Arg His Gln Trp Arg Leu Asp Thr Val Ile Ala Glu Thr Arg Tyr Gly 
        755                 760                 765             
Glu Lys Leu Pro Val Leu Asp Ile Asp Gly Asn Pro Val His Pro Glu 
    770                 775                 780                 
Glu Phe Gln His Phe Arg Lys Gln Trp Glu Gly His Pro Pro Asp Asn 
785                 790                 795                 800 
Pro Ala Glu Arg Thr Glu Arg Lys Leu Glu Lys Arg Phe Asp His Arg 
                805                 810                 815     
His His Gly Ile Asp Ala Leu Val Ile Ala Leu Thr Ser Arg Ser Leu 
            820                 825                 830         
Tyr Met Ser Leu Ala Arg Arg Tyr Val Glu Glu Ser Lys Lys Arg Ala 
        835                 840                 845             
Arg Gly Glu Lys Val Arg Arg Asp Trp Ser Ile Glu Pro Pro Met His 
    850                 855                 860                 
Asn Leu Arg Gly Gln Ala Leu Asp Met Ile Arg Ala Cys Asn Leu Thr 
865                 870                 875                 880 
Leu Lys Pro Asp Arg Asn Ala Ala Gly Arg Leu Phe Glu Asp Tyr Ala 
                885                 890                 895     
Tyr Gly Val His Phe Ser Asp Ala Ser Glu Arg Ala Gln Leu Thr Arg 
            900                 905                 910         
Arg Lys Thr Leu Ile Asp Leu Ala Asp Glu Lys Ser Ala Glu Lys Thr 
        915                 920                 925             
Arg Lys Asn Leu Gln Ser Ile Ala Ser Pro Glu Val Arg Gln Ile Val 
    930                 935                 940                 
Val Glu Ala Leu Gln Met Arg Leu Ser Ala Gly Gln Asn Pro Lys Gln 
945                 950                 955                 960 
Ala Leu Ser Lys Pro Val Leu Tyr Pro Ala Tyr Gly Thr Glu Ile Trp 
                965                 970                 975     
Arg Val Arg Cys Leu Gln Gly Tyr Ala Asp His Ala Val Arg Ile Val 
            980                 985                 990         
His Asn Ser Arg Gln Gly Glu His  Glu Lys Cys Leu Leu  Asn Asp Gly 
        995                 1000                 1005             
Tyr Ala  Cys Leu Glu Ile Arg  Ala Gly Glu Asn Gly  Lys His Gln 
    1010                 1015                 1020             
Ala Arg  Leu Val Thr Gln Arg  Glu Ala Gln Gly Arg  Asp Phe Met 
    1025                 1030                 1035             
Glu Thr  Gln Gln Gln Ala Lys  Arg Leu Phe Lys Gly  Asp Thr Val 
    1040                 1045                 1050             
Ile Asp  Arg Arg Asp Asp Arg  Lys Tyr Arg Val Gly  Tyr Phe Thr 
    1055                 1060                 1065             
Ala Glu  Gly Asn Ile Phe Leu  Ile Pro Phe Glu Asp  Thr Arg Asn 
    1070                 1075                 1080             
Phe Asp  Lys Ile Asn Glu Arg  Asn Ser Gly Lys Lys  Lys Val Ser 
    1085                 1090                 1095             
Phe Asn  Gln Ala His Arg Leu  Glu Arg Val 
    1100                 1105             

<210>  70
<211>  36
<212>  DNA
<213>  Bacillus cereus

<400>  70
atcatatcat atcgagtttt agtaaggaac tatagc                                 36

<210>  71
<211>  36
<212>  DNA
<213>  Brevibacillus laterosporus

<400>  71
atcatatcat atcgagtttt ggtaaggaac tatagc                                 36

<210>  72
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  CRISPR repeat consensus Locus 8

<400>  72
atcataatac agcaatggct ttaatggaac tatgac                                 36

<210>  73
<211>  36
<212>  DNA
<213>  Bacillus cereus

<400>  73
atcatagcat agcgatgttt cttttggaac tatagc                                 36

<210>  74
<211>  36
<212>  DNA
<213>  Lactobacillus fermentum

<400>  74
gtcttggatg agtgtcagat cagtagttcc gagtac                                 36

<210>  75
<211>  36
<212>  DNA
<213>  Enterococcus faecalis

<400>  75
gttttagagt catgttgttt agaatggtac caaaac                                 36

<210>  76
<211>  36
<212>  DNA
<213>  Bacillus cereus

<400>  76
gttttagagt catgttgttt agaatggtac caaaac                                 36

<210>  77
<211>  36
<212>  DNA
<213>  Enterococcus faecalis

<400>  77
gttttagagt catgttgttt agaatggtac caaaac                                 36

<210>  78
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  CRISPR repeat consensus Locus 14

<400>  78
gttttagagc tatgttgaat tgaatgcttc caaaac                                 36

<210>  79
<211>  36
<212>  DNA
<213>  Enterococcus faecalis

<400>  79
gtttttgtac tctcaataat ttcttatcag taaaac                                 36

<210>  80
<211>  47
<212>  DNA
<213>  Artificial sequence

<220>
<223>  CRISPR repeat consensus Locus 16

<400>  80
gttgtgctgt atctcaaaga tacggataaa tgaaagcaat tcacaac                     47

<210>  81
<211>  47
<212>  DNA
<213>  Artificial sequence

<220>
<223>  CRISPR repeat consensus Locus 17

<400>  81
gttgtgacta atcacgaaga taataaattt tgaaagcaat tcacaac                     47

<210>  82
<211>  47
<212>  DNA
<213>  Artificial sequence

<220>
<223>  CRISPR repeat consensus Locus 18

<400>  82
gctgtgacta atcacgaaga taataatttt tgaaagcaat tcacaac                     47

<210>  83
<211>  47
<212>  DNA
<213>  Artificial sequence

<220>
<223>  CRISPR repeat consensus Locus 19

<400>  83
gctgtgacta atcacgaaga taataatttt tgaaagcaat tcacaac                     47

<210>  84
<211>  47
<212>  DNA
<213>  Artificial sequence

<220>
<223>  CRISPR repeat consensus Locus 20

<400>  84
gctgtgacta atcacgaaga taataatttt tgaaagcaat tcacaac                     47

<210>  85
<211>  47
<212>  DNA
<213>  Artificial sequence

<220>
<223>  CRISPR repeat consensus Locus 21

<400>  85
gttgtgttat atctcaaaga tactcaaaaa tgaaagcaat tcacaac                     47

<210>  86
<211>  47
<212>  DNA
<213>  Artificial sequence

<220>
<223>  CRISPR repeat consensus Locus 22

<400>  86
gctgtgacta atcacgaaga taataatttt tgaaagcaat tcacaac                     47

<210>  87
<211>  46
<212>  DNA
<213>  Artificial sequence

<220>
<223>  CRISPR repeat consensus Locus 23

<400>  87
gttgggaatc ataagtaaaa atacaatttt gaaagcaatt cacaac                      46

<210>  88
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  CRISPR repeat consensus Locus 24

<400>  88
gttgtggttt gattaaagat tagaaaacac gatatt                                 36

<210>  89
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  CRISPR repeat consensus Locus 25

<400>  89
gttgtggttt gattaaagat tagaaaacac gatatc                                 36

<210>  90
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  CRISPR repeat consensus Locus 26

<400>  90
gttgtggttt gattaaagat tagaaaacac gatatt                                 36

<210>  91
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  CRISPR repeat consensus Locus 27

<400>  91
aggttatcag tcattccgat ggtggggtat cggaac                                 36

<210>  92
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  CRISPR repeat consensus Locus 28

<400>  92
aggttatcag tcattccgat ggtggggtat cggaac                                 36

<210>  93
<211>  36
<212>  DNA
<213>  Bacillus cereus

<400>  93
atcatatcat atcaagtttt ggtaagttgc tatagt                                 36

<210>  94
<211>  36
<212>  DNA
<213>  Brevibacillus laterosporus

<400>  94
atcatatcat atcaagtttt ggtaagttgc tatagt                                 36

<210>  95
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  anti repeat Locus 8

<400>  95
atcatggtac agcaatggct ttgatgtttc tatgat                                 36

<210>  96
<211>  36
<212>  DNA
<213>  Bacillus cereus

<400>  96
atcatatcat agcgatgttt cttaagttat tatagt                                 36

<210>  97
<211>  38
<212>  DNA
<213>  Lactobacillus fermentum

<400>  97
atcttgacta tgagtgttag atcagtagtc tcgaatgt                               38

<210>  98
<211>  38
<212>  DNA
<213>  Enterococcus faecalis

<400>  98
attttaactt gctatgttgt ttagaatagt cccaaaag                               38

<210>  99
<211>  38
<212>  DNA
<213>  Bacillus cereus

<400>  99
attttaactt gctatgttgt ttagaatagt cccaaaag                               38

<210>  100
<211>  38
<212>  DNA
<213>  Enterococcus faecalis

<400>  100
attttaactt gctatgttgt ttagaatagt cccaaaag                               38

<210>  101
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  anti repeat Locus 14

<400>  101
attttaactt gctatattga attgaatgct accaatgg                               38

<210>  102
<211>  38
<212>  DNA
<213>  Enterococcus faecalis

<400>  102
attttactga taagaaatta ttgagaatct acaaaaat                               38

<210>  103
<211>  47
<212>  DNA
<213>  Artificial sequence

<220>
<223>  anti repeat Locus 16

<400>  103
attgtgaatt gctttcggtt acaaatctaa aaattatttt tttaact                     47

<210>  104
<211>  47
<212>  DNA
<213>  Artificial sequence

<220>
<223>  anti repeat Locus 17

<400>  104
attgtgaatt gctttcaaaa tttatatgac aaatatagaa gaaaaaa                     47

<210>  105
<211>  47
<212>  DNA
<213>  Artificial sequence

<220>
<223>  anti repeat Locus 18

<400>  105
attgtgaatt gctttcaaaa ttattgatac aaatataaaa gaaaaaa                     47

<210>  106
<211>  47
<212>  DNA
<213>  Artificial sequence

<220>
<223>  anti repeat Locus 19

<400>  106
attgtgaatt gctttcaaaa ttattgatac aaatataaaa gaaaaaa                     47

<210>  107
<211>  47
<212>  DNA
<213>  Artificial sequence

<220>
<223>  anti repeat Locus 20

<400>  107
attgtgaatt gctttcaaaa ttattgatac aaatataaaa gaaaaaa                     47

<210>  108
<211>  47
<212>  DNA
<213>  Artificial sequence

<220>
<223>  anti repeat Locus 21

<400>  108
attgtgaatt gctttcggat acaaatctaa aaataatatt tttaatc                     47

<210>  109
<211>  47
<212>  DNA
<213>  Artificial sequence

<220>
<223>  anti repeat Locus 22

<400>  109
attgtgaatt gcttttcaaa attattaata caaatataga agaaaaa                     47

<210>  110
<211>  45
<212>  DNA
<213>  Artificial sequence

<220>
<223>  anti repeat Locus 23

<400>  110
attgtgaatt gcttcaaaat tgtattgcaa taatacaata aaata                       45

<210>  111
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  anti repeat Locus 24

<400>  111
attgtgataa gattaaagat tagaaatttt aatcag                                 36

<210>  112
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  anti repeat Locus 25

<400>  112
attgtgataa gattaaagat tagaaatttt aatcag                                 36

<210>  113
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  anti repeat Locus 26

<400>  113
attgtgataa gattaaagat tagaaatttt aatcag                                 36

<210>  114
<211>  39
<212>  DNA
<213>  Artificial sequence

<220>
<223>  anti repeat Locus 27

<400>  114
gttgccgata gtccccacca tcggaatgac tgatacgct                              39

<210>  115
<211>  39
<212>  DNA
<213>  Artificial sequence

<220>
<223>  anti repeat Locus 28

<400>  115
gttgccgata gtccccacca tcggaataac tgatacgct                              39

<210>  116
<211>  16
<212>  RNA
<213>  Bacillus cereus

<400>  116
gcuauaguuc cuuacu                                                       16

<210>  117
<211>  16
<212>  RNA
<213>  Brevibacillus laterosporus

<400>  117
gcuauaguuc cuuacc                                                       16

<210>  118
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  sgRNA repeat region for Cas-Locus 8

<400>  118
gucauaguuc cauuaaagc                                                    19

<210>  119
<211>  20
<212>  RNA
<213>  Bacillus cereus

<400>  119
gcuauaguuc caaaagaaac                                                   20

<210>  120
<211>  21
<212>  RNA
<213>  Lactobacillus fermentum

<400>  120
gucuuggaug agugucagau c                                                 21

<210>  121
<211>  17
<212>  RNA
<213>  Enterococcus faecalis

<400>  121
guuuuagagu cauguug                                                      17

<210>  122
<211>  17
<212>  RNA
<213>  Bacillus cereus

<400>  122
guuuuagagu cauguug                                                      17

<210>  123
<211>  17
<212>  RNA
<213>  Enterococcus faecalis

<400>  123
guuuuagagu cauguug                                                      17

<210>  124
<211>  17
<212>  RNA
<213>  Artificial sequence

<220>
<223>  sgRNA repeat region for Cas-Locus 14

<400>  124
guuuuagagc uauguug                                                      17

<210>  125
<211>  16
<212>  RNA
<213>  Enterococcus faecalis

<400>  125
guuuuuguac ucucaa                                                       16

<210>  126
<211>  22
<212>  RNA
<213>  Artificial sequence

<220>
<223>  sgRNA repeat region for Cas-Locus 16

<400>  126
guugugaauu gcuuucauuu au                                                22

<210>  127
<211>  25
<212>  RNA
<213>  Artificial sequence

<220>
<223>  sgRNA repeat region for Cas-Locus 17

<400>  127
guugugaauu gcuuucaaaa uuuau                                             25

<210>  128
<211>  26
<212>  RNA
<213>  Artificial sequence

<220>
<223>  sgRNA repeat region for Cas-Locus 18

<400>  128
guugugaauu gcuuucaaaa auuauu                                            26

<210>  129
<211>  26
<212>  RNA
<213>  Artificial sequence

<220>
<223>  sgRNA repeat region for Cas-Locus 19

<400>  129
guugugaauu gcuuucaaaa auuauu                                            26

<210>  130
<211>  26
<212>  RNA
<213>  Unknown

<220>
<223>  sgRNA repeat region for Cas-Locus 20

<400>  130
guugugaauu gcuuucaaaa auuauu                                            26

<210>  131
<211>  26
<212>  RNA
<213>  Artificial sequence

<220>
<223>  sgRNA repeat region for Cas-Locus 21

<400>  131
guugugaauu gcuuucauuu uugagu                                            26

<210>  132
<211>  23
<212>  RNA
<213>  Artificial sequence

<220>
<223>  sgRNA repeat region for Cas-Locus 22

<400>  132
guugugaauu gcuuucaaaa auu                                               23

<210>  133
<211>  22
<212>  RNA
<213>  Artificial sequence

<220>
<223>  sgRNA repeat region for Cas-Locus 23

<400>  133
guugugaauu gcuuucaaaa uu                                                22

<210>  134
<211>  16
<212>  RNA
<213>  Artificial sequence

<220>
<223>  sgRNA repeat region for Cas-Locus 24

<400>  134
guugugguuu gauuaa                                                       16

<210>  135
<211>  16
<212>  RNA
<213>  Artificial sequence

<220>
<223>  sgRNA repeat region for Cas-Locus 25

<400>  135
guugugguuu gauuaa                                                       16

<210>  136
<211>  16
<212>  RNA
<213>  Artificial sequence

<220>
<223>  sgRNA repeat region for Cas-Locus 26

<400>  136
guugugguuu gauuaa                                                       16

<210>  137
<211>  15
<212>  RNA
<213>  Artificial sequence

<220>
<223>  sgRNA repeat region for Cas-Locus 27

<400>  137
guuccgauac cccac                                                        15

<210>  138
<211>  15
<212>  RNA
<213>  Artificial sequence

<220>
<223>  sgRNA repeat region for Cas-Locus 28

<400>  138
guuccgauac cccac                                                        15

<210>  139
<211>  16
<212>  RNA
<213>  Bacillus cereus

<400>  139
gguaaguugc uauagu                                                       16

<210>  140
<211>  16
<212>  RNA
<213>  Brevibacillus laterosporus

<400>  140
gguaaguugc uauagu                                                       16

<210>  141
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  sgRNA anti-repeat region for Cas-Locus 8

<400>  141
gcuuugaugu uucuaugau                                                    19

<210>  142
<211>  20
<212>  RNA
<213>  Bacillus cereus

<400>  142
guuucuuaag uuauuauagu                                                   20

<210>  143
<211>  23
<212>  RNA
<213>  Lactobacillus fermentum

<400>  143
gaucuaacac ucauagucaa gau                                               23

<210>  144
<211>  19
<212>  RNA
<213>  Enterococcus faecalis

<400>  144
caacauagca aguuaaaau                                                    19

<210>  145
<211>  19
<212>  RNA
<213>  Bacillus cereus

<400>  145
caacauagca aguuaaaau                                                    19

<210>  146
<211>  19
<212>  RNA
<213>  Enterococcus faecalis

<400>  146
caacauagca aguuaaaau                                                    19

<210>  147
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  sgRNA anti-repeat region for Cas-Locus 14

<400>  147
caauauagca aguuaaaau                                                    19

<210>  148
<211>  18
<212>  RNA
<213>  Enterococcus faecalis

<400>  148
uugagaaucu acaaaaau                                                     18

<210>  149
<211>  22
<212>  RNA
<213>  Artificial sequence

<220>
<223>  sgRNA anti-repeat region for Cas-Locus 16

<400>  149
guaaccgaaa gcaauucaca au                                                22

<210>  150
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA anti-repeat region for Cas-Locus 17

<400>  150
auaaauuuug aaagcaauuc acaau                                             25

<210>  151
<211>  25
<212>  RNA
<213>  Artificial sequence

<220>
<223>  sgRNA anti-repeat region for Cas-Locus 18

<400>  151
aauaauuuug aaagcaauuc acaau                                             25

<210>  152
<211>  25
<212>  RNA
<213>  Artificial sequence

<220>
<223>  sgRNA anti-repeat region for Cas-Locus 19

<400>  152
aauaauuuug aaagcaauuc acaau                                             25

<210>  153
<211>  25
<212>  RNA
<213>  Unknown

<220>
<223>  sgRNA anti-repeat region for Cas-Locus 20

<400>  153
aauaauuuug aaagcaauuc acaau                                             25

<210>  154
<211>  26
<212>  RNA
<213>  Artificial sequence

<220>
<223>  sgRNA anti-repeat region for Cas-Locus 21

<400>  154
auuuguaucc gaaagcaauu cacaau                                            26

<210>  155
<211>  23
<212>  RNA
<213>  Artificial sequence

<220>
<223>  sgRNA anti-repeat region for Cas-Locus 22

<400>  155
aauuuugaaa agcaauucac aau                                               23

<210>  156
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  sgRNA anti-repeat region for Cas-Locus 23

<400>  156
aauuuugaag caauucacaa u                                                 21

<210>  157
<211>  16
<212>  RNA
<213>  Artificial sequence

<220>
<223>  sgRNA anti-repeat region for Cas-Locus 24

<400>  157
uuaaucuuau cacaau                                                       16

<210>  158
<211>  16
<212>  RNA
<213>  Artificial sequence

<220>
<223>  sgRNA anti-repeat region for Cas-Locus 25

<400>  158
uuaaucuuau cacaau                                                       16

<210>  159
<211>  16
<212>  RNA
<213>  Artificial sequence

<220>
<223>  sgRNA anti-repeat region for Cas-Locus 26

<400>  159
uuaaucuuau cacaau                                                       16

<210>  160
<211>  18
<212>  RNA
<213>  Artificial sequence

<220>
<223>  sgRNA anti-repeat region for Cas-Locus 27

<400>  160
guggggacua ucggcaac                                                     18

<210>  161
<211>  18
<212>  RNA
<213>  Artificial sequence

<220>
<223>  sgRNA anti-repeat region for Cas-Locus 28

<400>  161
guggggacua ucggcaac                                                     18

<210>  162
<211>  118
<212>  RNA
<213>  Bacillus cereus

<400>  162
aagggcaaca gacccgaggc guuggggauc gccuagcccg uuuuuacggg cucucccuau       60
auucaaaaua augacaaacg agcaccuugg agaauuuauu uccgaggugc uuuuuuuu        118

<210>  163
<211>  118
<212>  RNA
<213>  Brevibacillus laterosporus

<400>  163
aagggcaaca gacccgaggc guuggggauc gccuagcccg uucuuacggg cucuccccac       60
aaucaaaaua augacaaacg agcaccucgg agcauuuauu uccgaggugc uuuuuuuu        118

<210>  164
<211>  114
<212>  RNA
<213>  Artificial sequence

<220>
<223>  sgRNA 3 prime tracrRNA for Cas-Locus 8

<400>  164
aagggcuuug gcccguggcg uaggggaucg ccugcccauu uuaaugggcu ucuccccauc       60
uauuuaauga gaguuuuaca accuuggcua uucuuaaaua gcuaagguuu uuuu            114

<210>  165
<211>  100
<212>  RNA
<213>  Bacillus cereus

<400>  165
aagggcaaug acccguggcg uuuggggauc gccuuauccu guauggauau ucuccccaug       60
uuaaaagcac cuacgcauaa cgcuauggug cuuuuauuuu                            100

<210>  166
<211>  99
<212>  RNA
<213>  Lactobacillus fermentum

<400>  166
caaacgagug guuuuccacg aguuauuacu uuugagccau guuauucugg ccauacauau       60
aauaaaaagg agucgauuua aucggcuccu uuuuacuuu                              99

<210>  167
<211>  53
<212>  RNA
<213>  Enterococcus faecalis

<400>  167
aagguuuuaa ccguaaucaa cuguaaagug gcgcuguuuc ggcgcuuuuu uuu              53

<210>  168
<211>  53
<212>  RNA
<213>  Bacillus cereus

<400>  168
aagguuuuaa ccguaaucaa cuguaaagug gcgcuguuuc ggcgcuuuuu uug              53

<210>  169
<211>  56
<212>  RNA
<213>  Enterococcus faecalis

<400>  169
aagguuucaa ccguaaucaa cuguaaagug gcgcuguuuc ggcgcuuuuu uuguuu           56

<210>  170
<211>  55
<212>  RNA
<213>  Artificial sequence

<220>
<223>  sgRNA 3 prime tracrRNA for Cas-Locus 14

<400>  170
aaggcuuugu ccgucaucag cuucuaggag caagcgcugu cucggcgcuu uuuuu            55

<210>  171
<211>  49
<212>  RNA
<213>  Enterococcus faecalis

<400>  171
aaggcauuuu gccgaauuua ccgcccuaca uauguagggc gguuuuuuu                   49

<210>  172
<211>  51
<212>  RNA
<213>  Artificial sequence

<220>
<223>  sgRNA 3 prime tracrRNA for Cas-Locus 16

<400>  172
aaggauuauu ccguugugaa aacauucaag gcgggguaac ucgccuuuuc c                51

<210>  173
<211>  51
<212>  RNA
<213>  Artificial sequence

<220>
<223>  sgRNA 3 prime tracrRNA for Cas-Locus 17

<400>  173
aaggauuauu ccguugugaa aacauucaag gcggggcaac ucgccuuuuu u                51

<210>  174
<211>  59
<212>  RNA
<213>  Artificial sequence

<220>
<223>  sgRNA 3 prime tracrRNA for Cas-Locus 18

<400>  174
aaggauuauu ccguugugaa aacauuuagc gccucgacua ccuucggggc auuuuuauu        59

<210>  175
<211>  60
<212>  RNA
<213>  Artificial sequence

<220>
<223>  sgRNA 3 prime tracrRNA for Cas-Locus 19

<400>  175
aaggauuauu ccguugugaa aacauuuagc gccucgacua ccuucggggc auuuuuauua       60

<210>  176
<211>  60
<212>  RNA
<213>  Unknown

<220>
<223>  sgRNA 3 prime tracrRNA for Cas-Locus 20

<400>  176
aaggauuauu ccguugugaa aacauuuaga gccucgacua ccuucggggc auuuuuauuu       60

<210>  177
<211>  60
<212>  RNA
<213>  Artificial sequence

<220>
<223>  sgRNA 3 prime tracrRNA for Cas-Locus 21

<400>  177
aaggauuauu ccguugugaa aacauuuagc gccucgccua ucugcggggc auuuuuauuu       60

<210>  178
<211>  57
<212>  RNA
<213>  Artificial sequence

<220>
<223>  sgRNA 3 prime tracrRNA for Cas-Locus 22

<400>  178
aaggauuauu ccguugugaa aacauucaag gcggggcaac ucgucuuuuu ucuuuuu          57

<210>  179
<211>  52
<212>  RNA
<213>  Artificial sequence

<220>
<223>  sgRNA 3 prime tracrRNA for Cas-Locus 23

<400>  179
aaggauuauu ccguugugaa aacauuuaag gcggggagac ucgccuuuuu cu               52

<210>  180
<211>  55
<212>  RNA
<213>  Artificial sequence

<220>
<223>  sgRNA 3 prime tracrRNA for Cas-Locus 24

<400>  180
aaggcuauau gccguagaug aaaaucuuua guccugcuuc ggugggacuu uucau            55

<210>  181
<211>  55
<212>  RNA
<213>  Artificial sequence

<220>
<223>  sgRNA 3 prime tracrRNA for Cas-Locus 25

<400>  181
aaggcuacau gccguagaug aaaaucuuua guccugcuuc ggugggacuu uuuuu            55

<210>  182
<211>  55
<212>  RNA
<213>  Artificial sequence

<220>
<223>  sgRNA 3 prime tracrRNA for Cas-Locus 26

<400>  182
aaggcuauau gccguagaua aaaaucuuua guccugcuuc ggugggacuu uuuuu            55

<210>  183
<211>  66
<212>  RNA
<213>  Artificial sequence

<220>
<223>  sgRNA 3 prime tracrRNA for Cas-Locus 27

<400>  183
aaggcuaagu accucgguac gaagccaacc gauacaaacg gucaucucgg ugaccguuuu       60
ucuuuu                                                                  66

<210>  184
<211>  66
<212>  RNA
<213>  Artificial sequence

<220>
<223>  sgRNA 3 prime tracrRNA for Cas-Locus 28

<400>  184
aaggcugagu acuucgguac gaagccaacc gauacaaacg gccaccucgg uggccguuuu       60
uguuuu                                                                  66

<210>  185
<211>  174
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA for Cas-Locus 6

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  n is a, c, g, or u

<400>  185
nnnnnnnnnn nnnnnnnnnn gcuauaguuc cuuacugaaa gguaaguugc uauaguaagg       60
gcaacagacc cgaggcguug gggaucgccu agcccguuuu uacgggcucu cccuauauuc      120
aaaauaauga caaacgagca ccuuggagaa uuuauuuccg aggugcuuuu uuuu            174

<210>  186
<211>  174
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA for Cas-Locus 7

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  n is a, c, g, or u

<400>  186
nnnnnnnnnn nnnnnnnnnn gcuauaguuc cuuaccgaaa gguaaguugc uauaguaagg       60
gcaacagacc cgaggcguug gggaucgccu agcccguucu uacgggcucu ccccacaauc      120
aaaauaauga caaacgagca ccucggagca uuuauuuccg aggugcuuuu uuuu            174

<210>  187
<211>  176
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA for Cas-Locus 8

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  n is a, c, g, or u

<400>  187
nnnnnnnnnn nnnnnnnnnn gucauaguuc cauuaaagcg aaagcuuuga uguuucuaug       60
auaagggcuu uggcccgugg cguaggggau cgccugccca uuuuaauggg cuucucccca      120
ucuauuuaau gagaguuuua caaccuuggc uauucuuaaa uagcuaaggu uuuuuu          176

<210>  188
<211>  164
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA for Cas-Locus 9

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  n is a, c, g, or u

<400>  188
nnnnnnnnnn nnnnnnnnnn gcuauaguuc caaaagaaac gaaaguuucu uaaguuauua       60
uaguaagggc aaugacccgu ggcguuuggg gaucgccuua uccuguaugg auauucuccc      120
cauguuaaaa gcaccuacgc auaacgcuau ggugcuuuua uuuu                       164

<210>  189
<211>  167
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA for Cas-Locus 10

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  n is a, c, g, or u

<400>  189
nnnnnnnnnn nnnnnnnnnn gucuuggaug agugucagau cgaaagaucu aacacucaua       60
gucaagauca aacgaguggu uuuccacgag uuauuacuuu ugagccaugu uauucuggcc      120
auacauauaa uaaaaaggag ucgauuuaau cggcuccuuu uuacuuu                    167

<210>  190
<211>  113
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA for Cas-Locus 11

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  n is a, c, g, or u

<400>  190
nnnnnnnnnn nnnnnnnnnn guuuuagagu cauguuggaa acaacauagc aaguuaaaau       60
aagguuuuaa ccguaaucaa cuguaaagug gcgcuguuuc ggcgcuuuuu uuu             113

<210>  191
<211>  113
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA for Cas-Locus 12

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  n is a, c, g, or u

<400>  191
nnnnnnnnnn nnnnnnnnnn guuuuagagu cauguuggaa acaacauagc aaguuaaaau       60
aagguuuuaa ccguaaucaa cuguaaagug gcgcuguuuc ggcgcuuuuu uug             113

<210>  192
<211>  116
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA for Cas-Locus 13

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  n is a, c, g, or u

<400>  192
nnnnnnnnnn nnnnnnnnnn guuuuagagu cauguuggaa acaacauagc aaguuaaaau       60
aagguuucaa ccguaaucaa cuguaaagug gcgcuguuuc ggcgcuuuuu uuguuu          116

<210>  193
<211>  115
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA for Cas-Locus 14

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  n is a, c, g, or u

<400>  193
nnnnnnnnnn nnnnnnnnnn guuuuagagc uauguuggaa acaauauagc aaguuaaaau       60
aaggcuuugu ccgucaucag cuucuaggag caagcgcugu cucggcgcuu uuuuu           115

<210>  194
<211>  107
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA for Cas-Locus 15

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  n is a, c, g, or u

<400>  194
nnnnnnnnnn nnnnnnnnnn guuuuuguac ucucaagaaa uugagaaucu acaaaaauaa       60
ggcauuuugc cgaauuuacc gcccuacaua uguagggcgg uuuuuuu                    107

<210>  195
<211>  119
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA for Cas-Locus 16

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  n is a, c, g, or u

<400>  195
nnnnnnnnnn nnnnnnnnnn guugugaauu gcuuucauuu augaaaguaa ccgaaagcaa       60
uucacaauaa ggauuauucc guugugaaaa cauucaaggc gggguaacuc gccuuuucc       119

<210>  196
<211>  125
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA for Cas-Locus 17

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  n is a, c, g, or u

<400>  196
nnnnnnnnnn nnnnnnnnnn guugugaauu gcuuucaaaa uuuaugaaaa uaaauuuuga       60
aagcaauuca caauaaggau uauuccguug ugaaaacauu caaggcgggg caacucgccu      120
uuuuu                                                                  125

<210>  197
<211>  134
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA for Cas-Locus 18

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  n is a, c, g, or u

<400>  197
nnnnnnnnnn nnnnnnnnnn guugugaauu gcuuucaaaa auuauugaaa aauaauuuug       60
aaagcaauuc acaauaagga uuauuccguu gugaaaacau uuagcgccuc gacuaccuuc      120
ggggcauuuu uauu                                                        134

<210>  198
<211>  135
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA for Cas-Locus 19

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  n is a, c, g, or u

<400>  198
nnnnnnnnnn nnnnnnnnnn guugugaauu gcuuucaaaa auuauugaaa aauaauuuug       60
aaagcaauuc acaauaagga uuauuccguu gugaaaacau uuagcgccuc gacuaccuuc      120
ggggcauuuu uauua                                                       135

<210>  199
<211>  135
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA for Cas-Locus 20

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  n is a, c, g, or u

<400>  199
nnnnnnnnnn nnnnnnnnnn guugugaauu gcuuucaaaa auuauugaaa aauaauuuug       60
aaagcaauuc acaauaagga uuauuccguu gugaaaacau uuagagccuc gacuaccuuc      120
ggggcauuuu uauuu                                                       135

<210>  200
<211>  136
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA for Cas-Locus 21

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  n is a, c, g, or u

<400>  200
nnnnnnnnnn nnnnnnnnnn guugugaauu gcuuucauuu uugagugaaa auuuguaucc       60
gaaagcaauu cacaauaagg auuauuccgu ugugaaaaca uuuagcgccu cgccuaucug      120
cggggcauuu uuauuu                                                      136

<210>  201
<211>  127
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA for Cas-Locus 22

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  n is a, c, g, or u

<400>  201
nnnnnnnnnn nnnnnnnnnn guugugaauu gcuuucaaaa auugaaaaau uuugaaaagc       60
aauucacaau aaggauuauu ccguugugaa aacauucaag gcggggcaac ucgucuuuuu      120
ucuuuuu                                                                127

<210>  202
<211>  119
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA for Cas-Locus 23

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  n is a, c, g, or u

<400>  202
nnnnnnnnnn nnnnnnnnnn guugugaauu gcuuucaaaa uugaaaaauu uugaagcaau       60
ucacaauaag gauuauuccg uugugaaaac auuuaaggcg gggagacucg ccuuuuucu       119

<210>  203
<211>  111
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA for Cas-Locus 24

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  n is a, c, g, or u

<400>  203
nnnnnnnnnn nnnnnnnnnn guugugguuu gauuaagaaa uuaaucuuau cacaauaagg       60
cuauaugccg uagaugaaaa ucuuuagucc ugcuucggug ggacuuuuca u               111

<210>  204
<211>  111
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA for Cas-Locus 25

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  n is a, c, g, or u

<400>  204
nnnnnnnnnn nnnnnnnnnn guugugguuu gauuaagaaa uuaaucuuau cacaauaagg       60
cuacaugccg uagaugaaaa ucuuuagucc ugcuucggug ggacuuuuuu u               111

<210>  205
<211>  111
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA for Cas-Locus 26

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  n is a, c, g, or u

<400>  205
nnnnnnnnnn nnnnnnnnnn guugugguuu gauuaagaaa uuaaucuuau cacaauaagg       60
cuauaugccg uagauaaaaa ucuuuagucc ugcuucggug ggacuuuuuu u               111

<210>  206
<211>  123
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA for Cas-Locus 27

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  n is a, c, g, or u

<400>  206
nnnnnnnnnn nnnnnnnnnn guuccgauac cccacgaaag uggggacuau cggcaacaag       60
gcuaaguacc ucgguacgaa gccaaccgau acaaacgguc aucucgguga ccguuuuucu      120
uuu                                                                    123

<210>  207
<211>  123
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA for Cas-Locus 28

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  n is a, c, g, or u

<400>  207
nnnnnnnnnn nnnnnnnnnn guuccgauac cccacgaaag uggggacuau cggcaacaag       60
gcugaguacu ucgguacgaa gccaaccgau acaaacggcc accucggugg ccguuuuugu      120
uuu                                                                    123